locus-tag	class	description
CLD04_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLD04_00010	COG0592	DNA-directed DNA polymerase activity
CLD04_00015	COG2501	S4 domain
CLD04_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLD04_00030	COG0187	DNA topoisomerase II activity
CLD04_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLD04_00070	COG0516	GMP reductase activity
CLD04_00070	COG0517	IMP dehydrogenase activity
CLD04_00075	COG1686	Belongs to the peptidase S11 family
CLD04_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CLD04_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CLD04_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLD04_00105	COG1428	Deoxynucleoside kinase
CLD04_00110	COG1428	Deoxynucleoside kinase
CLD04_00115	COG3858	chitin binding
CLD04_00115	COG1388	LysM domain
CLD04_00120	COG1335	isochorismatase
CLD04_00125	COG0590	tRNA wobble adenosine to inosine editing
CLD04_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLD04_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLD04_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLD04_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
CLD04_00195	COG3853	Toxic anion resistance protein (TelA)
CLD04_00200	COG1982	Orn Lys Arg decarboxylase major
CLD04_00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLD04_00210	COG3870	Protein conserved in bacteria
CLD04_00215	COG1728	Protein conserved in bacteria
CLD04_00220	COG0470	DNA polymerase III
CLD04_00225	COG1774	PSP1 C-terminal conserved region
CLD04_00230	COG4467	Involved in initiation control of chromosome replication
CLD04_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLD04_00240	COG2827	Endonuclease containing a URI domain
CLD04_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLD04_00250	COG2002	toxin-antitoxin pair type II binding
CLD04_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLD04_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLD04_00260	COG0084	hydrolase, TatD family'
CLD04_00265	COG3583	domain protein
CLD04_00265	COG3584	3D domain protein
CLD04_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CLD04_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLD04_00285	COG4466	Protein conserved in bacteria
CLD04_00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLD04_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLD04_00305	COG0251	oxidation-reduction process
CLD04_00310	COG2088	sporulation resulting in formation of a cellular spore
CLD04_00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLD04_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLD04_00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLD04_00330	COG0193	aminoacyl-tRNA hydrolase activity
CLD04_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLD04_00345	COG2002	toxin-antitoxin pair type II binding
CLD04_00350	COG2244	polysaccharide biosynthetic process
CLD04_00355	COG3956	TIGRFAM MazG family protein
CLD04_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLD04_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CLD04_00380	COG1098	S1 RNA binding domain
CLD04_00395	COG2208	phosphoserine phosphatase activity
CLD04_00400	COG2304	oxidoreductase activity
CLD04_00405	COG0515	serine threonine protein kinase
CLD04_00410	COG0037	tRNA processing
CLD04_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLD04_00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLD04_00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLD04_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLD04_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLD04_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLD04_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
CLD04_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLD04_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLD04_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLD04_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLD04_00475	COG1396	sequence-specific DNA binding
CLD04_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLD04_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLD04_00565	COG4463	regulation of RNA biosynthetic process
CLD04_00570	COG3880	PFAM UvrB UvrC protein
CLD04_00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CLD04_00580	COG0542	response to heat
CLD04_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLD04_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CLD04_00595	COG4956	integral membrane protein (PIN domain superfamily)
CLD04_00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLD04_00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLD04_00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLD04_00620	COG1045	serine acetyltransferase
CLD04_00625	COG0215	cysteine-tRNA ligase activity
CLD04_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CLD04_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLD04_00640	COG3688	RNA-binding protein containing a PIN domain
CLD04_00645	COG1595	DNA-templated transcription, initiation
CLD04_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLD04_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLD04_00660	COG0250	Participates in transcription elongation, termination and antitermination
CLD04_00665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLD04_00670	COG0081	regulation of translation
CLD04_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLD04_00680	COG0222	ribosome binding
CLD04_00685	COG2813	Specifically methylates the guanine in position
CLD04_00690	COG0085	RNA polymerase activity
CLD04_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLD04_00700	COG1358	cellular component organization or biogenesis
CLD04_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLD04_00710	COG0049	tRNA binding
CLD04_00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLD04_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLD04_00725	COG0596	Alpha beta hydrolase
CLD04_00730	COG0051	transcription antitermination factor activity, RNA binding
CLD04_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLD04_00740	COG0088	Forms part of the polypeptide exit tunnel
CLD04_00745	COG0089	rRNA binding
CLD04_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLD04_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLD04_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLD04_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLD04_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLD04_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
CLD04_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLD04_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLD04_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLD04_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLD04_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLD04_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLD04_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLD04_00825	COG1841	ribosomal large subunit assembly
CLD04_00830	COG0200	Binds to the 23S rRNA
CLD04_00835	COG0201	protein transport
CLD04_00840	COG0563	adenylate kinase activity
CLD04_00845	COG0024	Methionine aminopeptidase
CLD04_00850	COG2163	COG2163 Ribosomal protein L14E L6E L27E
CLD04_00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLD04_00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLD04_00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLD04_00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLD04_00875	COG0202	RNA polymerase activity
CLD04_00880	COG0203	ribosomal protein L17
CLD04_00885	COG1122	ATPase activity
CLD04_00890	COG1122	ATPase activity
CLD04_00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLD04_00900	COG0101	tRNA pseudouridine synthase activity
CLD04_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLD04_00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLD04_00920	COG2226	methyltransferase
CLD04_00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLD04_00935	COG0489	protein tyrosine kinase activity
CLD04_00945	COG2194	sulfuric ester hydrolase activity
CLD04_00950	COG0726	polysaccharide deacetylase
CLD04_00985	COG2856	Zn peptidase
CLD04_00995	COG1395	domain, Protein
CLD04_01055	COG0305	Participates in initiation and elongation during chromosome replication
CLD04_01065	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CLD04_01150	COG1783	phage Terminase large subunit
CLD04_01155	COG5518	Phage portal protein
CLD04_01160	COG2369	cell adhesion
CLD04_01170	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CLD04_01175	COG4653	Phage capsid family
CLD04_01230	COG5280	Phage tail tape measure protein TP901
CLD04_01230	COG3953	SLT domain
CLD04_01235	COG1652	LysM domain
CLD04_01240	COG4193	domain, Protein
CLD04_01250	COG3628	GPW Gp25 family protein
CLD04_01255	COG3299	homolog of phage Mu protein gp47
CLD04_01260	COG3778	Protein conserved in bacteria
CLD04_01300	COG1388	LysM domain
CLD04_01300	COG3409	Peptidoglycan-binding domain 1 protein
CLD04_01300	COG5632	N-Acetylmuramoyl-L-alanine amidase
CLD04_01310	COG5444	nuclease activity
CLD04_01320	COG0457	Tetratricopeptide repeat
CLD04_01335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLD04_01395	COG0659	secondary active sulfate transmembrane transporter activity
CLD04_01400	COG0385	Bile acid
CLD04_01405	COG2819	hydrolase of the alpha beta superfamily
CLD04_01410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_01415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_01420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLD04_01425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLD04_01425	COG2207	Transcriptional regulator
CLD04_01430	COG3876	Protein conserved in bacteria
CLD04_01435	COG1472	Belongs to the glycosyl hydrolase 3 family
CLD04_01440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLD04_01445	COG1263	PTS System
CLD04_01445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_01450	COG1737	Transcriptional regulator
CLD04_01455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CLD04_01465	COG1683	Conserved Protein
CLD04_01495	COG1595	DNA-templated transcription, initiation
CLD04_01500	COG5662	AntiSigma factor
CLD04_01505	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLD04_01510	COG4856	YbbR-like protein
CLD04_01515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLD04_01525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLD04_01535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CLD04_01545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLD04_01550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLD04_01555	COG3002	Belongs to the UPF0753 family
CLD04_01560	COG0288	reversible hydration of carbon dioxide
CLD04_01570	COG5609	conserved protein (DUF2294)
CLD04_01590	COG0515	serine threonine protein kinase
CLD04_01605	COG1113	amino acid transport
CLD04_01620	COG2602	Beta-lactamase
CLD04_01625	COG2124	cytochrome p450
CLD04_01635	COG0531	amino acid
CLD04_01640	COG0584	glycerophosphoryl diester phosphodiesterase
CLD04_01645	COG2271	Major facilitator Superfamily
CLD04_01660	COG0456	acetyltransferase
CLD04_01660	COG1846	Transcriptional regulator
CLD04_01665	COG2271	Major facilitator Superfamily
CLD04_01675	COG3409	Peptidoglycan-binding domain 1 protein
CLD04_01680	COG0697	spore germination
CLD04_01685	COG1917	Cupin 2, conserved barrel domain protein
CLD04_01685	COG2207	Transcriptional regulator
CLD04_01690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CLD04_01695	COG3591	Belongs to the peptidase S1B family
CLD04_01705	COG0596	Alpha beta hydrolase
CLD04_01710	COG1183	phosphatidylcholine synthase activity
CLD04_01715	COG0586	Pfam SNARE associated Golgi protein
CLD04_01720	COG0688	phosphatidylethanolamine metabolic process
CLD04_01730	COG2312	Erythromycin esterase
CLD04_01740	COG1301	dicarboxylic acid transport
CLD04_01745	COG1263	PTS System
CLD04_01745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_01745	COG2190	(PTS) system
CLD04_01750	COG0363	glucosamine-6-phosphate deaminase activity
CLD04_01765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLD04_01770	COG0833	amino acid
CLD04_01775	COG2040	homocysteine
CLD04_01785	COG1115	amino acid carrier protein
CLD04_01790	COG2066	Belongs to the glutaminase family
CLD04_01795	COG4191	Histidine kinase
CLD04_01800	COG0784	Response regulator, receiver
CLD04_01805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLD04_01810	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_01820	COG4948	Mandelate Racemase Muconate Lactonizing
CLD04_01825	COG2186	Transcriptional regulator
CLD04_01845	COG0697	spore germination
CLD04_01850	COG0745	RESPONSE REGULATOR receiver
CLD04_01855	COG2205	protein histidine kinase activity
CLD04_01860	COG1131	(ABC) transporter
CLD04_01875	COG3773	Cell wall hydrolase
CLD04_01885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLD04_01885	COG0072	phenylalanine-tRNA ligase activity
CLD04_01915	COG0531	amino acid
CLD04_01930	COG0137	argininosuccinate synthase activity
CLD04_01935	COG0626	cystathionine gamma-synthase activity
CLD04_01940	COG1279	arginine transmembrane transporter activity
CLD04_01945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLD04_01960	COG3540	Alkaline phosphatase
CLD04_01965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLD04_01970	COG0805	protein transport
CLD04_01975	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CLD04_01980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLD04_01985	COG0477	Major facilitator Superfamily
CLD04_01990	COG1309	transcriptional regulator
CLD04_01995	COG0252	asparaginase activity
CLD04_02000	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CLD04_02005	COG1714	RDD family
CLD04_02010	COG3012	SEC-C Motif Domain Protein
CLD04_02010	COG1405	negative regulation of cell septum assembly
CLD04_02020	COG3279	Response regulator of the LytR AlgR family
CLD04_02025	COG4555	ABC transporter
CLD04_02030	COG1668	transmembrane transport
CLD04_02035	COG0667	Aldo Keto reductase
CLD04_02045	COG1595	DNA-templated transcription, initiation
CLD04_02050	COG1595	DNA-templated transcription, initiation
CLD04_02055	COG1876	peptidase activity
CLD04_02060	COG0457	Tetratricopeptide repeat
CLD04_02065	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_02070	COG0366	Alpha amylase catalytic
CLD04_02075	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLD04_02080	COG1121	(ABC) transporter
CLD04_02085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLD04_02090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLD04_02095	COG2310	stress, protein
CLD04_02100	COG2310	stress, protein
CLD04_02105	COG2310	stress, protein
CLD04_02110	COG0861	Integral membrane protein TerC family
CLD04_02120	COG3853	Toxic anion resistance protein (TelA)
CLD04_02125	COG0477	Major facilitator Superfamily
CLD04_02130	COG2814	Major facilitator Superfamily
CLD04_02135	COG0640	Transcriptional regulator
CLD04_02140	COG0517	IMP dehydrogenase activity
CLD04_02140	COG4175	Glycine betaine
CLD04_02145	COG4176	ABC-type proline glycine betaine transport system permease component
CLD04_02150	COG2113	Glycine betaine
CLD04_02155	COG1473	amidohydrolase
CLD04_02160	COG1288	antiporter activity
CLD04_02175	COG0039	L-malate dehydrogenase activity
CLD04_02180	COG1620	l-lactate permease
CLD04_02190	COG3403	YqcI/YcgG family
CLD04_02205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLD04_02210	COG1660	Displays ATPase and GTPase activities
CLD04_02215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLD04_02220	COG2226	methyltransferase
CLD04_02225	COG0583	DNA-binding transcription factor activity
CLD04_02230	COG3458	cephalosporin-C deacetylase activity
CLD04_02235	COG3541	Predicted nucleotidyltransferase
CLD04_02240	COG0506	proline dehydrogenase activity
CLD04_02245	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_02250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLD04_02255	COG2508	Transcriptional regulator
CLD04_02260	COG3689	TIGRFAM TIGR03943 family protein
CLD04_02265	COG0701	Predicted permease
CLD04_02270	COG2267	carboxylic ester hydrolase activity
CLD04_02275	COG0492	ferredoxin-NADP+ reductase activity
CLD04_02280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLD04_02280	COG1587	Uroporphyrinogen-III synthase
CLD04_02285	COG2146	nitrite reductase [NAD(P)H] activity
CLD04_02290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLD04_02295	COG0243	molybdopterin cofactor binding
CLD04_02300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLD04_02305	COG2223	nitrite transmembrane transporter activity
CLD04_02310	COG1469	GTP cyclohydrolase I activity
CLD04_02315	COG1376	ErfK ybiS ycfS ynhG family protein
CLD04_02330	COG0765	amino acid transport
CLD04_02335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLD04_02340	COG1714	RDD family
CLD04_02350	COG2723	6-phospho-beta-galactosidase activity
CLD04_02360	COG3209	COG3209 Rhs family protein
CLD04_02365	COG3290	protein histidine kinase activity
CLD04_02365	COG0840	transmembrane signaling receptor activity
CLD04_02370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CLD04_02375	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CLD04_02380	COG1733	regulation of RNA biosynthetic process
CLD04_02385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLD04_02390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLD04_02395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLD04_02405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLD04_02410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLD04_02415	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CLD04_02420	COG2814	Major facilitator Superfamily
CLD04_02430	COG0697	spore germination
CLD04_02435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLD04_02445	COG2364	Membrane
CLD04_02450	COG1126	abc transporter atp-binding protein
CLD04_02455	COG0765	amino acid transport
CLD04_02460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLD04_02465	COG0583	DNA-binding transcription factor activity
CLD04_02470	COG0163	prenyltransferase activity
CLD04_02475	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CLD04_02490	COG0596	Alpha beta hydrolase
CLD04_02495	COG3104	oligopeptide transport
CLD04_02500	COG5434	Belongs to the glycosyl hydrolase 28 family
CLD04_02510	COG0697	spore germination
CLD04_02520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CLD04_02525	COG1136	(ABC) transporter
CLD04_02530	COG0577	efflux transmembrane transporter activity
CLD04_02535	COG0745	RESPONSE REGULATOR receiver
CLD04_02540	COG5002	protein histidine kinase activity
CLD04_02540	COG3850	Histidine kinase
CLD04_02545	COG0457	Tetratricopeptide repeat
CLD04_02565	COG0527	aspartate kinase activity
CLD04_02570	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_02575	COG4605	iron ion homeostasis
CLD04_02580	COG4604	ABC transporter, ATP-binding protein
CLD04_02585	COG4607	ABC-type enterochelin transport system periplasmic component
CLD04_02590	COG2814	Major facilitator Superfamily
CLD04_02595	COG1309	transcriptional regulator
CLD04_02600	COG0778	Nitroreductase
CLD04_02605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CLD04_02610	COG0640	Transcriptional regulator
CLD04_02615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLD04_02620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CLD04_02625	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_02630	COG4975	Glucose uptake
CLD04_02635	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_02640	COG4549	nuclear export factor GLE1
CLD04_02645	COG1276	copper resistance
CLD04_02645	COG2372	response to copper ion
CLD04_02650	COG1349	DNA-binding transcription factor activity
CLD04_02660	COG2213	PTS system mannitol-specific
CLD04_02665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLD04_02670	COG0246	Mannitol dehydrogenase
CLD04_02675	COG0473	3-isopropylmalate dehydrogenase activity
CLD04_02680	COG0681	Belongs to the peptidase S26 family
CLD04_02685	COG0412	Dienelactone hydrolase
CLD04_02690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLD04_02700	COG0561	phosphatase activity
CLD04_02705	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CLD04_02710	COG1914	H( )-stimulated, divalent metal cation uptake system
CLD04_02715	COG4336	lyase activity
CLD04_02720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CLD04_02725	COG1984	allophanate hydrolase subunit 2
CLD04_02730	COG1414	Transcriptional regulator
CLD04_02735	COG2755	lipolytic protein G-D-S-L family
CLD04_02745	COG2329	Antibiotic biosynthesis monooxygenase
CLD04_02750	COG0768	penicillin binding
CLD04_02755	COG4989	oxidoreductase activity
CLD04_02760	COG3711	transcriptional antiterminator
CLD04_02765	COG0318	PFAM AMP-dependent synthetase and ligase
CLD04_02770	COG2226	methyltransferase
CLD04_02775	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_02780	COG1917	Cupin 2, conserved barrel domain protein
CLD04_02785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLD04_02790	COG3871	stress protein (general stress protein 26)
CLD04_02800	COG2814	Major facilitator Superfamily
CLD04_02805	COG1522	sequence-specific DNA binding
CLD04_02810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLD04_02810	COG0551	DNA topoisomerase type I activity
CLD04_02815	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CLD04_02825	COG5298	Protein conserved in bacteria
CLD04_02845	COG1914	H( )-stimulated, divalent metal cation uptake system
CLD04_02850	COG2261	transglycosylase associated protein
CLD04_02855	COG4876	unkown
CLD04_02860	COG2217	Heavy metal translocating P-type atpase
CLD04_02865	COG3729	General stress protein
CLD04_02870	COG0662	Cupin 2, conserved barrel domain protein
CLD04_02875	COG2329	Antibiotic biosynthesis monooxygenase
CLD04_02880	COG3546	catalase activity
CLD04_02885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLD04_02890	COG3290	protein histidine kinase activity
CLD04_02895	COG4565	transcriptional regulatory protein
CLD04_02900	COG1301	dicarboxylic acid transport
CLD04_02905	COG0628	permease
CLD04_02910	COG1131	(ABC) transporter
CLD04_02915	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CLD04_02925	COG1960	acyl-CoA dehydrogenase activity
CLD04_02940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLD04_02945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLD04_02950	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLD04_02955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLD04_02965	COG0513	Belongs to the DEAD box helicase family
CLD04_02970	COG3402	PFAM membrane-flanked domain
CLD04_02975	COG3428	Bacterial PH domain
CLD04_02980	COG0705	Rhomboid family
CLD04_02985	COG0736	holo-[acyl-carrier-protein] synthase activity
CLD04_02990	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CLD04_02995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLD04_03000	COG0864	Transcriptional regulator
CLD04_03005	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLD04_03010	COG1366	Belongs to the anti-sigma-factor antagonist family
CLD04_03015	COG1366	Belongs to the anti-sigma-factor antagonist family
CLD04_03020	COG2172	sigma factor antagonist activity
CLD04_03025	COG2208	phosphoserine phosphatase activity
CLD04_03030	COG1366	Belongs to the anti-sigma-factor antagonist family
CLD04_03035	COG2172	sigma factor antagonist activity
CLD04_03040	COG1191	sigma factor activity
CLD04_03045	COG2208	phosphoserine phosphatase activity
CLD04_03050	COG2183	response to ionizing radiation
CLD04_03060	COG3091	SprT-like family
CLD04_03100	COG0582	viral genome integration into host DNA
CLD04_03110	COG1396	sequence-specific DNA binding
CLD04_03135	COG1674	ftsk spoiiie
CLD04_03140	COG2946	Replication initiation factor
CLD04_03190	COG0433	COG0433 Predicted ATPase
CLD04_03205	COG0741	lytic transglycosylase activity
CLD04_03205	COG0791	NLP P60 protein
CLD04_03225	COG0457	Tetratricopeptide repeat
CLD04_03250	COG5444	nuclease activity
CLD04_03255	COG1476	TRANSCRIPTIONal
CLD04_03265	COG3239	Fatty acid desaturase
CLD04_03270	COG1278	Cold shock
CLD04_03275	COG1329	Transcriptional regulator
CLD04_03285	COG0697	spore germination
CLD04_03290	COG1917	Cupin 2, conserved barrel domain protein
CLD04_03290	COG2207	Transcriptional regulator
CLD04_03295	COG0697	spore germination
CLD04_03300	COG2207	Transcriptional regulator
CLD04_03300	COG3708	Transcriptional regulator
CLD04_03305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLD04_03315	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CLD04_03330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLD04_03335	COG1309	transcriptional regulator
CLD04_03340	COG0697	spore germination
CLD04_03345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLD04_03350	COG2030	dehydratase
CLD04_03355	COG3545	Serine hydrolase
CLD04_03360	COG1733	regulation of RNA biosynthetic process
CLD04_03365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLD04_03370	COG0640	Transcriptional regulator
CLD04_03375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CLD04_03380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLD04_03385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLD04_03390	COG0697	spore germination
CLD04_03395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLD04_03400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLD04_03405	COG0640	Transcriptional regulator
CLD04_03410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLD04_03425	COG4585	Histidine kinase
CLD04_03430	COG2197	response regulator
CLD04_03440	COG0596	Alpha beta hydrolase
CLD04_03445	COG1811	Na channel or pump
CLD04_03450	COG0789	Transcriptional regulator
CLD04_03450	COG4978	Transcriptional regulator
CLD04_03470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLD04_03475	COG0778	Nitroreductase
CLD04_03480	COG0346	lactoylglutathione lyase activity
CLD04_03485	COG2259	Doxx family
CLD04_03490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLD04_03505	COG2323	membrane
CLD04_03510	COG2323	membrane
CLD04_03515	COG0071	Belongs to the small heat shock protein (HSP20) family
CLD04_03530	COG1309	transcriptional regulator
CLD04_03540	COG0456	acetyltransferase
CLD04_03550	COG1113	amino acid transport
CLD04_03560	COG1846	Transcriptional regulator
CLD04_03565	COG1033	growth of symbiont in host cell
CLD04_03565	COG2409	Drug exporters of the RND superfamily
CLD04_03570	COG0778	Nitroreductase
CLD04_03575	COG1846	Transcriptional regulator
CLD04_03580	COG2814	Major facilitator Superfamily
CLD04_03585	COG0730	response to heat
CLD04_03590	COG1802	Transcriptional regulator
CLD04_03595	COG3858	chitin binding
CLD04_03595	COG1388	LysM domain
CLD04_03600	COG1819	glycosyl
CLD04_03610	COG1785	Belongs to the alkaline phosphatase family
CLD04_03615	COG5646	InterPro IPR014922
CLD04_03625	COG0454	-acetyltransferase
CLD04_03630	COG1078	dGTPase activity
CLD04_03635	COG1388	LysM domain
CLD04_03640	COG2814	Major facilitator Superfamily
CLD04_03645	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLD04_03650	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLD04_03655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLD04_03660	COG2723	6-phospho-beta-galactosidase activity
CLD04_03665	COG2188	Transcriptional regulator
CLD04_03670	COG1940	carbohydrate kinase activity
CLD04_03675	COG1482	cell wall glycoprotein biosynthetic process
CLD04_03680	COG4124	Belongs to the glycosyl hydrolase 26 family
CLD04_03725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CLD04_03730	COG0802	atpase or kinase
CLD04_03735	COG1214	PFAM Peptidase M22, glycoprotease
CLD04_03740	COG0456	acetyltransferase
CLD04_03745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLD04_03750	COG0488	(ABC) transporter
CLD04_03755	COG0315	cyclic pyranopterin monophosphate synthase activity
CLD04_03760	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLD04_03765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLD04_03770	COG0805	protein transport
CLD04_03785	COG1266	CAAX protease self-immunity
CLD04_03790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLD04_03795	COG0459	protein refolding
CLD04_03800	COG3409	Peptidoglycan-binding domain 1 protein
CLD04_03815	COG0457	Tetratricopeptide repeat
CLD04_03820	COG1063	alcohol dehydrogenase
CLD04_03825	COG2211	Major facilitator Superfamily
CLD04_03830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLD04_03835	COG1842	Phage shock protein A
CLD04_03840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLD04_03845	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLD04_03850	COG4260	virion core protein, lumpy skin disease virus
CLD04_03860	COG2814	Major facilitator Superfamily
CLD04_03865	COG1063	alcohol dehydrogenase
CLD04_03870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLD04_03875	COG0823	Involved in the tonB-independent uptake of proteins
CLD04_03890	COG2267	carboxylic ester hydrolase activity
CLD04_03900	COG2132	Multicopper oxidase
CLD04_03905	COG1113	amino acid transport
CLD04_03915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLD04_03920	COG0714	Associated with various cellular activities
CLD04_03925	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CLD04_03930	COG1305	Transglutaminase-like
CLD04_03935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLD04_03935	COG0519	Catalyzes the synthesis of GMP from XMP
CLD04_03945	COG2252	PERMEase
CLD04_03950	COG3064	Membrane
CLD04_03960	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CLD04_03970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLD04_03975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CLD04_03980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLD04_03985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLD04_03990	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLD04_03995	COG0047	phosphoribosylformylglycinamidine synthase activity
CLD04_04000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLD04_04005	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLD04_04010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLD04_04015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLD04_04020	COG0138	bifunctional purine biosynthesis protein purh
CLD04_04025	COG0151	Belongs to the GarS family
CLD04_04030	COG1522	sequence-specific DNA binding
CLD04_04035	COG0531	amino acid
CLD04_04045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLD04_04050	COG1470	cell adhesion involved in biofilm formation
CLD04_04055	COG4496	protein, YerC YecD
CLD04_04060	COG0069	glutamate synthase activity
CLD04_04065	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CLD04_04070	COG0210	DNA helicase
CLD04_04075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLD04_04080	COG4851	CamS sex pheromone cAM373 precursor
CLD04_04090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLD04_04095	COG1285	pathogenesis
CLD04_04100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLD04_04105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLD04_04110	COG0154	amidase activity
CLD04_04115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLD04_04125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLD04_04130	COG1597	lipid kinase activity
CLD04_04135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLD04_04140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLD04_04145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLD04_04150	COG1002	Type II restriction enzyme, methylase subunits
CLD04_04155	COG1061	Type III restriction enzyme res subunit
CLD04_04160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLD04_04180	COG5444	nuclease activity
CLD04_04190	COG0457	Tetratricopeptide repeat
CLD04_04200	COG0217	transcriptional regulatory protein
CLD04_04210	COG1309	transcriptional regulator
CLD04_04215	COG3631	Ketosteroid isomerase-related protein
CLD04_04235	COG3546	catalase activity
CLD04_04240	COG0454	-acetyltransferase
CLD04_04250	COG5578	integral membrane protein
CLD04_04255	COG2972	Histidine kinase
CLD04_04260	COG1653	transport
CLD04_04265	COG1175	transmembrane transport
CLD04_04270	COG0395	ABC-type sugar transport system, permease component
CLD04_04275	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CLD04_04280	COG2207	Transcriptional regulator
CLD04_04285	COG2755	lipolytic protein G-D-S-L family
CLD04_04295	COG5578	integral membrane protein
CLD04_04305	COG3401	FG-GAP repeat protein
CLD04_04310	COG2755	lipolytic protein G-D-S-L family
CLD04_04325	COG1653	transport
CLD04_04330	COG4209	transmembrane transport
CLD04_04335	COG0395	ABC-type sugar transport system, permease component
CLD04_04340	COG1486	melibiose metabolic process
CLD04_04345	COG2323	membrane
CLD04_04350	COG2329	Antibiotic biosynthesis monooxygenase
CLD04_04355	COG0346	lactoylglutathione lyase activity
CLD04_04370	COG5583	Uncharacterized small protein (DUF2292)
CLD04_04375	COG0670	Belongs to the BI1 family
CLD04_04390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLD04_04400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CLD04_04400	COG2124	cytochrome p450
CLD04_04405	COG1368	sulfuric ester hydrolase activity
CLD04_04410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLD04_04415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLD04_04420	COG1442	glycosyl transferase family 8
CLD04_04425	COG1216	Glycosyl transferase, family 2
CLD04_04430	COG1442	glycosyl transferase family 8
CLD04_04435	COG2223	nitrite transmembrane transporter activity
CLD04_04440	COG1011	Hydrolase
CLD04_04445	COG0531	amino acid
CLD04_04450	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_04455	COG0840	transmembrane signaling receptor activity
CLD04_04460	COG0488	(ABC) transporter
CLD04_04470	COG0789	Transcriptional regulator
CLD04_04475	COG2814	Major facilitator Superfamily
CLD04_04490	COG0488	(ABC) transporter
CLD04_04495	COG0513	Belongs to the DEAD box helicase family
CLD04_04500	COG0456	acetyltransferase
CLD04_04505	COG2130	NADP-dependent
CLD04_04510	COG1120	ATPase activity
CLD04_04515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_04525	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CLD04_04545	COG3866	Pectate lyase
CLD04_04550	COG0471	metal ion transport
CLD04_04555	COG3290	protein histidine kinase activity
CLD04_04560	COG4565	transcriptional regulatory protein
CLD04_04565	COG3181	Tripartite tricarboxylate transporter family receptor
CLD04_04570	COG2851	Citrate transporter
CLD04_04575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLD04_04580	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CLD04_04585	COG1254	Belongs to the acylphosphatase family
CLD04_04590	COG2258	MOSC domain
CLD04_04610	COG0024	Methionine aminopeptidase
CLD04_04615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_04615	COG1263	PTS System
CLD04_04620	COG1368	sulfuric ester hydrolase activity
CLD04_04645	COG1263	PTS System
CLD04_04645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_04650	COG0366	Alpha amylase catalytic
CLD04_04655	COG2188	Transcriptional regulator
CLD04_04660	COG0778	Nitroreductase
CLD04_04665	COG0737	Belongs to the 5'-nucleotidase family
CLD04_04670	COG0693	protein deglycase activity
CLD04_04675	COG2814	Major facilitator Superfamily
CLD04_04680	COG4840	Belongs to the UPF0435 family
CLD04_04685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLD04_04690	COG4980	gas vesicle protein
CLD04_04695	COG1295	ribonuclease BN
CLD04_04700	COG0477	Major facilitator Superfamily
CLD04_04705	COG0387	Pfam Sodium calcium exchanger
CLD04_04715	COG0668	transmembrane transport
CLD04_04720	COG0535	radical SAM domain protein
CLD04_04730	COG0726	polysaccharide deacetylase
CLD04_04740	COG0598	Magnesium transport protein CorA
CLD04_04745	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CLD04_04750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLD04_04760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLD04_04765	COG4637	Psort location Cytoplasmic, score
CLD04_04775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CLD04_04780	COG0022	dehydrogenase e1 component
CLD04_04785	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLD04_04790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLD04_04795	COG3284	Transcriptional regulator
CLD04_04805	COG1742	UPF0060 membrane protein
CLD04_04825	COG4842	Belongs to the WXG100 family
CLD04_04830	COG1486	melibiose metabolic process
CLD04_04835	COG1737	Transcriptional regulator
CLD04_04840	COG1263	PTS System
CLD04_04840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_04845	COG1132	(ABC) transporter
CLD04_04850	COG1132	(ABC) transporter
CLD04_04855	COG2259	Doxx family
CLD04_04860	COG2514	catechol 2,3-dioxygenase activity
CLD04_04865	COG4977	sequence-specific DNA binding
CLD04_04865	COG1917	Cupin 2, conserved barrel domain protein
CLD04_04870	COG2814	Major facilitator Superfamily
CLD04_04875	COG1082	Xylose isomerase domain protein TIM barrel
CLD04_04880	COG0673	inositol 2-dehydrogenase activity
CLD04_04885	COG4585	Histidine kinase
CLD04_04890	COG2197	response regulator
CLD04_04900	COG1131	(ABC) transporter
CLD04_04905	COG0842	Transport permease protein
CLD04_04905	COG1511	domain protein
CLD04_04910	COG0842	Transport permease protein
CLD04_04920	COG1695	Transcriptional regulator
CLD04_04925	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CLD04_04930	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
CLD04_04935	COG2318	DinB family
CLD04_04940	COG2814	Major facilitator Superfamily
CLD04_04945	COG1846	Transcriptional regulator
CLD04_04950	COG0392	lysyltransferase activity
CLD04_04950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CLD04_04955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLD04_04960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_04965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_04970	COG0384	phenazine biosynthesis protein PhzF
CLD04_04975	COG0778	Nitroreductase
CLD04_04990	COG1090	epimerase
CLD04_04995	COG2137	regulation of response to DNA damage stimulus
CLD04_05005	COG2814	Major facilitator Superfamily
CLD04_05025	COG3103	Sh3 type 3 domain protein
CLD04_05030	COG5658	integral membrane protein
CLD04_05035	COG0596	Alpha beta hydrolase
CLD04_05040	COG0463	Glycosyl transferase, family 2
CLD04_05045	COG4485	Bacterial membrane protein, YfhO
CLD04_05050	COG1988	membrane-bound metal-dependent
CLD04_05055	COG1194	a g-specific adenine glycosylase
CLD04_05065	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_05080	COG3557	Belongs to the UPF0374 family
CLD04_05085	COG1132	(ABC) transporter
CLD04_05090	COG4129	membrane
CLD04_05095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLD04_05100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLD04_05105	COG0735	belongs to the Fur family
CLD04_05220	COG4326	sporulation control protein
CLD04_05230	COG5577	PFAM Coat F domain
CLD04_05235	COG3340	Belongs to the peptidase S51 family
CLD04_05240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLD04_05245	COG0277	FAD linked oxidase domain protein
CLD04_05255	COG0753	catalase activity
CLD04_05260	COG1116	anion transmembrane transporter activity
CLD04_05265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLD04_05270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLD04_05275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLD04_05285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLD04_05295	COG1476	TRANSCRIPTIONal
CLD04_05305	COG3382	B3 4 domain protein
CLD04_05310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLD04_05320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLD04_05325	COG0789	Transcriptional regulator
CLD04_05330	COG1664	Polymer-forming cytoskeletal
CLD04_05335	COG1664	Polymer-forming cytoskeletal
CLD04_05340	COG2766	serine protein kinase
CLD04_05345	COG2718	Belongs to the UPF0229 family
CLD04_05350	COG1846	Transcriptional regulator
CLD04_05355	COG1566	PFAM secretion protein HlyD family protein
CLD04_05360	COG2814	Major facilitator Superfamily
CLD04_05365	COG0655	NAD(P)H dehydrogenase (quinone) activity
CLD04_05385	COG1725	Transcriptional regulator
CLD04_05390	COG1131	(ABC) transporter
CLD04_05395	COG1131	(ABC) transporter
CLD04_05400	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CLD04_05405	COG1278	Cold shock
CLD04_05415	COG1464	Belongs to the NlpA lipoprotein family
CLD04_05420	COG3706	GGDEF domain
CLD04_05425	COG1823	symporter activity
CLD04_05450	COG0737	Belongs to the 5'-nucleotidase family
CLD04_05450	COG4085	toxin activity
CLD04_05450	COG1525	nuclease
CLD04_05455	COG3764	Sortase (surface protein transpeptidase)
CLD04_05460	COG0564	pseudouridine synthase activity
CLD04_05470	COG0517	IMP dehydrogenase activity
CLD04_05475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLD04_05480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLD04_05480	COG3153	acetyltransferase
CLD04_05485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLD04_05490	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CLD04_05495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLD04_05500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLD04_05505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CLD04_05510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLD04_05515	COG2203	Gaf domain
CLD04_05515	COG4585	Histidine kinase
CLD04_05520	COG2197	response regulator
CLD04_05525	COG0431	NADPH-dependent FMN reductase
CLD04_05540	COG0791	NLP P60 protein
CLD04_05540	COG1388	LysM domain
CLD04_05545	COG1959	2 iron, 2 sulfur cluster binding
CLD04_05550	COG0668	transmembrane transport
CLD04_05555	COG2719	SpoVR family
CLD04_05560	COG1785	Belongs to the alkaline phosphatase family
CLD04_05565	COG1388	LysM domain
CLD04_05565	COG0791	NLP P60 protein
CLD04_05570	COG0583	DNA-binding transcription factor activity
CLD04_05575	COG0372	Belongs to the citrate synthase family
CLD04_05580	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_05585	COG0531	amino acid
CLD04_05590	COG0733	neurotransmitter:sodium symporter activity
CLD04_05595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLD04_05600	COG0456	acetyltransferase
CLD04_05615	COG1595	DNA-templated transcription, initiation
CLD04_05620	COG0667	Aldo Keto reductase
CLD04_05625	COG0204	Acyl-transferase
CLD04_05635	COG1253	flavin adenine dinucleotide binding
CLD04_05640	COG0789	Transcriptional regulator
CLD04_05645	COG0436	Aminotransferase
CLD04_05650	COG1253	flavin adenine dinucleotide binding
CLD04_05655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLD04_05660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLD04_05665	COG0584	glycerophosphoryl diester phosphodiesterase
CLD04_05675	COG0668	transmembrane transport
CLD04_05680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CLD04_05685	COG0726	polysaccharide deacetylase
CLD04_05690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLD04_05695	COG1757	Na H antiporter
CLD04_05700	COG0589	response to stress
CLD04_05710	COG1132	(ABC) transporter
CLD04_05715	COG1132	(ABC) transporter
CLD04_05720	COG0702	epimerase
CLD04_05740	COG0189	ligase activity
CLD04_05745	COG0189	ligase activity
CLD04_05750	COG4399	Belongs to the UPF0754 family
CLD04_05755	COG3679	Belongs to the UPF0342 family
CLD04_05765	COG0561	phosphatase activity
CLD04_05770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLD04_05775	COG0475	glutathione-regulated potassium exporter activity
CLD04_05780	COG0490	domain, Protein
CLD04_05790	COG1024	Enoyl-CoA hydratase
CLD04_05800	COG4152	abc transporter atp-binding protein
CLD04_05805	COG1668	transmembrane transport
CLD04_05810	COG0420	3'-5' exonuclease activity
CLD04_05815	COG4717	serine-type aminopeptidase activity
CLD04_05820	COG3481	metal-dependent phosphohydrolase, HD sub domain
CLD04_05830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLD04_05860	COG1846	Transcriptional regulator
CLD04_05865	COG4980	gas vesicle protein
CLD04_05880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLD04_05885	COG0537	adenosine 5'-monophosphoramidase activity
CLD04_05890	COG1131	(ABC) transporter
CLD04_05895	COG4473	ABC transporter
CLD04_05905	COG1473	amidohydrolase
CLD04_05910	COG3069	C4-dicarboxylate transmembrane transporter activity
CLD04_05920	COG2329	Antibiotic biosynthesis monooxygenase
CLD04_05925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLD04_05930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLD04_05945	COG1309	transcriptional regulator
CLD04_05950	COG1511	domain protein
CLD04_05955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLD04_05960	COG4377	Putative membrane peptidase family (DUF2324)
CLD04_05970	COG1363	Peptidase, m42
CLD04_05975	COG4405	Protein conserved in bacteria
CLD04_05980	COG1301	dicarboxylic acid transport
CLD04_05990	COG1234	tRNA 3'-trailer cleavage
CLD04_05995	COG0095	Lipoate-protein ligase
CLD04_06000	COG0702	epimerase
CLD04_06005	COG0318	PFAM AMP-dependent synthetase and ligase
CLD04_06015	COG0501	Belongs to the peptidase M48B family
CLD04_06020	COG1404	Belongs to the peptidase S8 family
CLD04_06025	COG0456	acetyltransferase
CLD04_06030	COG0604	alcohol dehydrogenase
CLD04_06035	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CLD04_06040	COG0406	alpha-ribazole phosphatase activity
CLD04_06045	COG0183	Belongs to the thiolase family
CLD04_06050	COG0318	PFAM AMP-dependent synthetase and ligase
CLD04_06055	COG1268	BioY protein
CLD04_06060	COG0840	transmembrane signaling receptor activity
CLD04_06070	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_06080	COG4903	ComK protein
CLD04_06085	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_06095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLD04_06110	COG0398	Pfam SNARE associated Golgi protein
CLD04_06115	COG0681	Belongs to the peptidase S26 family
CLD04_06120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLD04_06125	COG1846	Transcriptional regulator
CLD04_06130	COG0738	Major facilitator superfamily
CLD04_06140	COG0561	phosphatase activity
CLD04_06150	COG1609	Transcriptional regulator
CLD04_06155	COG3180	Ammonia monooxygenase
CLD04_06160	COG0477	Major facilitator Superfamily
CLD04_06160	COG2814	Major facilitator Superfamily
CLD04_06165	COG4533	DNA binding
CLD04_06175	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CLD04_06180	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CLD04_06185	COG1074	ATP-dependent DNA helicase activity
CLD04_06190	COG0420	3'-5' exonuclease activity
CLD04_06195	COG0419	ATPase involved in DNA repair
CLD04_06200	COG1403	HNH endonuclease
CLD04_06240	COG5337	Spore coat protein CotH
CLD04_06245	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLD04_06255	COG1404	Belongs to the peptidase S8 family
CLD04_06265	COG0367	asparagine synthase
CLD04_06270	COG2318	DinB family
CLD04_06275	COG1562	ergosterol biosynthetic process
CLD04_06280	COG0534	Mate efflux family protein
CLD04_06285	COG1917	Cupin 2, conserved barrel domain protein
CLD04_06285	COG2207	Transcriptional regulator
CLD04_06290	COG1609	Transcriptional regulator
CLD04_06295	COG0673	inositol 2-dehydrogenase activity
CLD04_06300	COG2318	DinB family
CLD04_06305	COG1279	arginine transmembrane transporter activity
CLD04_06310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLD04_06315	COG1357	PFAM Pentapeptide repeats (8 copies)
CLD04_06320	COG2267	carboxylic ester hydrolase activity
CLD04_06325	COG0529	Catalyzes the synthesis of activated sulfate
CLD04_06340	COG2045	Belongs to the ComB family
CLD04_06345	COG1809	phosphosulfolactate synthase activity
CLD04_06350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLD04_06355	COG4948	Mandelate Racemase Muconate Lactonizing
CLD04_06445	COG2814	Major facilitator Superfamily
CLD04_06450	COG0454	-acetyltransferase
CLD04_06455	COG2153	protein acetylation
CLD04_06460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLD04_06460	COG0646	methionine synthase
CLD04_06465	COG1666	GTP binding
CLD04_06470	COG2996	Protein conserved in bacteria
CLD04_06490	COG1695	Transcriptional regulator
CLD04_06505	COG3227	Zinc metalloprotease (Elastase)
CLD04_06510	COG1307	EDD domain protein, DegV family
CLD04_06515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLD04_06530	COG0561	phosphatase activity
CLD04_06535	COG1073	alpha beta
CLD04_06540	COG2151	metal-sulfur cluster biosynthetic enzyme
CLD04_06550	COG0277	FAD linked oxidase domain protein
CLD04_06555	COG2271	Major facilitator Superfamily
CLD04_06560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLD04_06575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLD04_06580	COG0505	Belongs to the CarA family
CLD04_06585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLD04_06590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLD04_06605	COG2267	carboxylic ester hydrolase activity
CLD04_06615	COG1744	ABC transporter substrate-binding protein PnrA-like
CLD04_06630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLD04_06635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLD04_06640	COG5504	Zn-dependent protease
CLD04_06645	COG0444	Belongs to the ABC transporter superfamily
CLD04_06650	COG4608	Belongs to the ABC transporter superfamily
CLD04_06660	COG0601	transmembrane transport
CLD04_06665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLD04_06675	COG0180	Tryptophanyl-tRNA synthetase
CLD04_06680	COG4166	transmembrane transport
CLD04_06685	COG0601	transmembrane transport
CLD04_06690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLD04_06695	COG0444	Belongs to the ABC transporter superfamily
CLD04_06700	COG4608	Belongs to the ABC transporter superfamily
CLD04_06705	COG2814	Major facilitator Superfamily
CLD04_06710	COG0456	acetyltransferase
CLD04_06715	COG1393	Belongs to the ArsC family
CLD04_06720	COG0861	Integral membrane protein TerC family
CLD04_06725	COG4862	establishment of competence for transformation
CLD04_06730	COG4469	Competence protein
CLD04_06735	COG1164	Oligoendopeptidase f
CLD04_06755	COG2346	COG2346, Truncated hemoglobins
CLD04_06760	COG0741	lytic transglycosylase activity
CLD04_06765	COG4116	CYTH
CLD04_06775	COG2357	RelA SpoT domain protein
CLD04_06780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLD04_06785	COG0564	pseudouridine synthase activity
CLD04_06790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLD04_06795	COG0475	glutathione-regulated potassium exporter activity
CLD04_06795	COG0569	domain protein
CLD04_06800	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CLD04_06805	COG0352	thiamine-phosphate diphosphorylase activity
CLD04_06810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLD04_06815	COG2104	thiamine diphosphate biosynthetic process
CLD04_06820	COG2022	thiamine diphosphate biosynthetic process
CLD04_06825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLD04_06830	COG0351	phosphomethylpyrimidine kinase
CLD04_06835	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CLD04_06890	COG0210	DNA helicase
CLD04_06900	COG2153	protein acetylation
CLD04_06905	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CLD04_06910	COG2382	esterase
CLD04_06915	COG0626	cystathionine gamma-synthase activity
CLD04_06920	COG0626	cystathionine gamma-synthase activity
CLD04_06925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLD04_06930	COG5505	Protein of unknown function (DUF819)
CLD04_07040	COG5444	nuclease activity
CLD04_07130	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CLD04_07135	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_07145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLD04_07145	COG3711	transcriptional antiterminator
CLD04_07150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLD04_07150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLD04_07150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLD04_07155	COG1482	cell wall glycoprotein biosynthetic process
CLD04_07165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLD04_07175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLD04_07195	COG0109	protoheme IX farnesyltransferase activity
CLD04_07205	COG0726	polysaccharide deacetylase
CLD04_07220	COG5504	Zn-dependent protease
CLD04_07225	COG2205	protein histidine kinase activity
CLD04_07240	COG2427	Protein of unknown function (DUF1641)
CLD04_07250	COG1051	belongs to the nudix hydrolase family
CLD04_07260	COG2124	cytochrome p450
CLD04_07265	COG1819	glycosyl
CLD04_07275	COG1587	Uroporphyrinogen-III synthase
CLD04_07280	COG0390	transport system, permease component
CLD04_07285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLD04_07290	COG0697	spore germination
CLD04_07295	COG4297	protein containing double-stranded beta helix domain
CLD04_07305	COG1252	NADH dehydrogenase
CLD04_07310	COG1904	glucuronate isomerase
CLD04_07315	COG2211	Major facilitator Superfamily
CLD04_07320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CLD04_07325	COG1063	alcohol dehydrogenase
CLD04_07330	COG1312	Catalyzes the dehydration of D-mannonate
CLD04_07335	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_07340	COG2271	Major facilitator Superfamily
CLD04_07345	COG1609	Transcriptional regulator
CLD04_07350	COG0246	Mannitol dehydrogenase
CLD04_07355	COG2721	sulfolactate sulfo-lyase activity
CLD04_07360	COG0730	response to heat
CLD04_07365	COG2318	DinB family
CLD04_07370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLD04_07375	COG0457	Tetratricopeptide repeat
CLD04_07385	COG2350	Protein conserved in bacteria
CLD04_07390	COG3409	Peptidoglycan-binding domain 1 protein
CLD04_07390	COG5632	N-Acetylmuramoyl-L-alanine amidase
CLD04_07390	COG1388	LysM domain
CLD04_07400	COG4195	phage-related replication protein
CLD04_07405	COG3546	catalase activity
CLD04_07410	COG2856	Zn peptidase
CLD04_07415	COG1396	sequence-specific DNA binding
CLD04_07425	COG1522	sequence-specific DNA binding
CLD04_07430	COG1484	DNA-dependent DNA replication
CLD04_07450	COG1595	DNA-templated transcription, initiation
CLD04_07455	COG5484	DNA packaging
CLD04_07455	COG3728	DNA packaging
CLD04_07460	COG1783	phage Terminase large subunit
CLD04_07465	COG5518	Phage portal protein
CLD04_07470	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CLD04_07475	COG4653	Phage capsid family
CLD04_07525	COG5412	phage tail tape measure protein
CLD04_07525	COG3953	SLT domain
CLD04_07530	COG1652	LysM domain
CLD04_07535	COG4193	domain, Protein
CLD04_07545	COG3628	GPW Gp25 family protein
CLD04_07550	COG3299	homolog of phage Mu protein gp47
CLD04_07555	COG3778	Protein conserved in bacteria
CLD04_07595	COG5632	N-Acetylmuramoyl-L-alanine amidase
CLD04_07595	COG3409	Peptidoglycan-binding domain 1 protein
CLD04_07610	COG0306	phosphate transporter
CLD04_07615	COG1392	Phosphate transport regulator
CLD04_07620	COG0531	amino acid
CLD04_07625	COG0346	lactoylglutathione lyase activity
CLD04_07630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLD04_07635	COG0463	Glycosyl transferase, family 2
CLD04_07640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLD04_07645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLD04_07650	COG2362	D-Aminopeptidase
CLD04_07655	COG0601	transmembrane transport
CLD04_07660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLD04_07665	COG0444	Belongs to the ABC transporter superfamily
CLD04_07670	COG4166	transmembrane transport
CLD04_07675	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLD04_07680	COG4948	Mandelate Racemase Muconate Lactonizing
CLD04_07685	COG0791	NLP P60 protein
CLD04_07690	COG4608	Belongs to the ABC transporter superfamily
CLD04_07695	COG2706	6-phosphogluconolactonase activity
CLD04_07700	COG1834	amidinotransferase
CLD04_07705	COG1607	acyl-coa hydrolase
CLD04_07710	COG1017	nitric oxide dioxygenase activity
CLD04_07710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CLD04_07720	COG2323	membrane
CLD04_07725	COG2318	DinB family
CLD04_07730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLD04_07735	COG2076	Multidrug Resistance protein
CLD04_07740	COG2076	Multidrug Resistance protein
CLD04_07745	COG0788	formyltetrahydrofolate deformylase activity
CLD04_07750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CLD04_07755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLD04_07760	COG1764	response to oxidative stress
CLD04_07765	COG1846	Transcriptional regulator
CLD04_07770	COG1764	response to oxidative stress
CLD04_07780	COG0590	tRNA wobble adenosine to inosine editing
CLD04_07790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLD04_07795	COG1404	Belongs to the peptidase S8 family
CLD04_07800	COG1366	Belongs to the anti-sigma-factor antagonist family
CLD04_07805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLD04_07810	COG1122	ATPase activity
CLD04_07815	COG4721	ABC-type cobalt transport system, permease component
CLD04_07825	COG0745	RESPONSE REGULATOR receiver
CLD04_07830	COG5002	protein histidine kinase activity
CLD04_07830	COG3850	Histidine kinase
CLD04_07835	COG3212	peptidase
CLD04_07840	COG3212	peptidase
CLD04_07855	COG2239	Acts as a magnesium transporter
CLD04_07860	COG0789	Transcriptional regulator
CLD04_07875	COG1846	Transcriptional regulator
CLD04_07880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLD04_07885	COG0726	polysaccharide deacetylase
CLD04_07890	COG1408	metallophosphoesterase
CLD04_07900	COG0463	Glycosyl transferase, family 2
CLD04_07905	COG1793	dna ligase
CLD04_07905	COG3285	dna ligase
CLD04_07910	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CLD04_07915	COG3300	MHYT domain
CLD04_07915	COG5001	Diguanylate cyclase
CLD04_07920	COG0586	Pfam SNARE associated Golgi protein
CLD04_07925	COG0861	Integral membrane protein TerC family
CLD04_07930	COG1191	sigma factor activity
CLD04_07950	COG0501	Belongs to the peptidase M48B family
CLD04_07955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLD04_07970	COG3594	Acyltransferase
CLD04_07975	COG5002	protein histidine kinase activity
CLD04_07980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLD04_07985	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLD04_07990	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CLD04_07995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLD04_08000	COG0436	Aminotransferase
CLD04_08005	COG1850	ribulose-bisphosphate carboxylase activity
CLD04_08010	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CLD04_08015	COG0235	Class ii aldolase
CLD04_08020	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CLD04_08025	COG3339	Conserved Protein
CLD04_08040	COG3852	Histidine kinase
CLD04_08045	COG1846	Transcriptional regulator
CLD04_08050	COG1360	Flagellar Motor Protein
CLD04_08055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLD04_08060	COG0542	response to heat
CLD04_08065	COG3949	Membrane
CLD04_08070	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLD04_08075	COG0720	synthase
CLD04_08080	COG0602	queuosine metabolic process
CLD04_08085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLD04_08090	COG1733	regulation of RNA biosynthetic process
CLD04_08095	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_08100	COG1388	LysM domain
CLD04_08100	COG4641	Protein conserved in bacteria
CLD04_08105	COG1388	LysM domain
CLD04_08110	COG3858	chitin binding
CLD04_08120	COG4873	Protein conserved in bacteria
CLD04_08130	COG3773	Cell wall hydrolase
CLD04_08135	COG2244	polysaccharide biosynthetic process
CLD04_08140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLD04_08145	COG2217	Heavy metal translocating P-type atpase
CLD04_08155	COG0006	proline dipeptidase activity
CLD04_08160	COG1609	Transcriptional regulator
CLD04_08165	COG3711	transcriptional antiterminator
CLD04_08170	COG2190	(PTS) system
CLD04_08170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_08170	COG1263	PTS System
CLD04_08175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLD04_08180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLD04_08195	COG1533	DNA photolyase activity
CLD04_08200	COG0456	acetyltransferase
CLD04_08205	COG0840	transmembrane signaling receptor activity
CLD04_08210	COG2084	Dehydrogenase
CLD04_08215	COG2340	Cysteine-rich secretory protein family
CLD04_08220	COG0768	penicillin binding
CLD04_08225	COG4191	Histidine kinase
CLD04_08230	COG0436	Aminotransferase
CLD04_08240	COG0784	Response regulator, receiver
CLD04_08240	COG0835	chemotaxis
CLD04_08250	COG2814	Major facilitator Superfamily
CLD04_08255	COG1376	ErfK ybiS ycfS ynhG family protein
CLD04_08260	COG1408	metallophosphoesterase
CLD04_08265	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_08270	COG2200	EAL domain
CLD04_08275	COG4703	Protein of unknown function (DUF1797)
CLD04_08280	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CLD04_08290	COG0517	IMP dehydrogenase activity
CLD04_08295	COG0583	DNA-binding transcription factor activity
CLD04_08300	COG0716	FMN binding
CLD04_08310	COG0716	FMN binding
CLD04_08315	COG2171	N-acyltransferase activity
CLD04_08320	COG1473	amidohydrolase
CLD04_08335	COG0668	transmembrane transport
CLD04_08340	COG0450	alkyl hydroperoxide reductase
CLD04_08345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLD04_08365	COG0746	molybdenum cofactor guanylyltransferase activity
CLD04_08370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLD04_08375	COG0303	'Molybdopterin
CLD04_08380	COG1763	Mo-molybdopterin cofactor biosynthetic process
CLD04_08385	COG0314	molybdopterin synthase activity
CLD04_08390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CLD04_08395	COG1132	(ABC) transporter
CLD04_08400	COG1132	(ABC) transporter
CLD04_08410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLD04_08415	COG1136	(ABC) transporter
CLD04_08420	COG0577	efflux transmembrane transporter activity
CLD04_08425	COG1349	DNA-binding transcription factor activity
CLD04_08430	COG1105	Belongs to the carbohydrate kinase PfkB family
CLD04_08435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLD04_08435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLD04_08435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLD04_08440	COG0681	Belongs to the peptidase S26 family
CLD04_08450	COG0488	(ABC) transporter
CLD04_08455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLD04_08460	COG2309	aminopeptidase activity
CLD04_08470	COG1077	Cell shape determining protein MreB Mrl
CLD04_08475	COG2002	toxin-antitoxin pair type II binding
CLD04_08480	COG3852	Histidine kinase
CLD04_08485	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CLD04_08485	COG2105	PFAM AIG2 family protein
CLD04_08490	COG0569	domain protein
CLD04_08495	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLD04_08500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLD04_08510	COG0561	phosphatase activity
CLD04_08515	COG0242	peptide deformylase activity
CLD04_08525	COG0497	DNA recombination
CLD04_08530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CLD04_08535	COG0022	dehydrogenase e1 component
CLD04_08540	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLD04_08545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLD04_08550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLD04_08560	COG1982	Orn Lys Arg decarboxylase major
CLD04_08565	COG4476	Belongs to the UPF0223 family
CLD04_08570	COG4493	Belongs to the UPF0637 family
CLD04_08580	COG0483	inositol monophosphate 1-phosphatase activity
CLD04_08590	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CLD04_08610	COG1595	DNA-templated transcription, initiation
CLD04_08640	COG4896	Protein conserved in bacteria
CLD04_08650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLD04_08655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CLD04_08660	COG2066	Belongs to the glutaminase family
CLD04_08665	COG4838	Belongs to the UPF0358 family
CLD04_08670	COG0772	Belongs to the SEDS family
CLD04_08675	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CLD04_08680	COG1612	heme a metabolic process
CLD04_08685	COG0109	protoheme IX farnesyltransferase activity
CLD04_08690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CLD04_08690	COG2010	Cytochrome c
CLD04_08695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CLD04_08700	COG1845	cytochrome c oxidase, subunit III
CLD04_08705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CLD04_08710	COG3336	cytochrome c oxidase
CLD04_08720	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CLD04_08725	COG2340	Cysteine-rich secretory protein family
CLD04_08740	COG3679	Belongs to the UPF0342 family
CLD04_08745	COG4471	UPF0298 protein
CLD04_08750	COG0742	ribosomal rna small subunit methyltransferase
CLD04_08755	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLD04_08760	COG3314	Sporulation integral membrane protein YlbJ
CLD04_08765	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLD04_08770	COG3480	Lon protease (S16) C-terminal proteolytic domain
CLD04_08775	COG1323	Belongs to the UPF0348 family
CLD04_08785	COG1399	metal-binding, possibly nucleic acid-binding protein
CLD04_08790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLD04_08800	COG0454	-acetyltransferase
CLD04_08805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLD04_08810	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CLD04_08815	COG2001	Belongs to the MraZ family
CLD04_08820	COG0275	rRNA processing
CLD04_08825	COG4839	cell division protein FtsL
CLD04_08835	COG0768	penicillin binding
CLD04_08840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLD04_08845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLD04_08850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLD04_08855	COG0772	Belongs to the SEDS family
CLD04_08860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLD04_08865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLD04_08870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CLD04_08875	COG3879	Bacterial protein of unknown function (DUF881)
CLD04_08880	COG3879	Bacterial protein of unknown function (DUF881)
CLD04_08885	COG3856	small basic protein
CLD04_08890	COG0849	cell division
CLD04_08895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLD04_08975	COG1404	Belongs to the peptidase S8 family
CLD04_08975	COG4412	M6 family metalloprotease domain protein
CLD04_08985	COG1191	sigma factor activity
CLD04_08990	COG1191	sigma factor activity
CLD04_08995	COG1119	ATPase activity
CLD04_09000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLD04_09005	COG1873	PFAM PRC-barrel domain
CLD04_09015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLD04_09020	COG1799	cell septum assembly
CLD04_09025	COG0762	integral membrane protein
CLD04_09030	COG2302	S4 RNA-binding domain
CLD04_09035	COG3599	regulation of cell shape
CLD04_09040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLD04_09045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLD04_09050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLD04_09055	COG0564	pseudouridine synthase activity
CLD04_09060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLD04_09065	COG2233	PERMEase
CLD04_09070	COG0540	Belongs to the ATCase OTCase family
CLD04_09075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLD04_09080	COG0505	Belongs to the CarA family
CLD04_09085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLD04_09090	COG0543	2 iron, 2 sulfur cluster binding
CLD04_09095	COG0167	dihydroorotate dehydrogenase activity
CLD04_09100	COG0284	orotidine-5'-phosphate decarboxylase activity
CLD04_09105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLD04_09110	COG0175	sulfate reduction
CLD04_09115	COG0306	phosphate transporter
CLD04_09120	COG2046	Belongs to the sulfate adenylyltransferase family
CLD04_09125	COG0529	Catalyzes the synthesis of activated sulfate
CLD04_09130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLD04_09135	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CLD04_09140	COG1648	precorrin-2 dehydrogenase activity
CLD04_09150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLD04_09155	COG1561	YicC-like family, N-terminal region
CLD04_09160	COG2052	Domain of unknown function (DUF370)
CLD04_09165	COG0194	GDP metabolic process
CLD04_09170	COG1758	RNA polymerase activity
CLD04_09175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLD04_09180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLD04_09185	COG0242	peptide deformylase activity
CLD04_09190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLD04_09195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLD04_09195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLD04_09200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLD04_09205	COG0631	protein serine/threonine phosphatase activity
CLD04_09210	COG2815	serine threonine protein kinase
CLD04_09210	COG0515	serine threonine protein kinase
CLD04_09215	COG1162	GTPase activity
CLD04_09220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLD04_09225	COG1564	THIamine pyrophosphokinase
CLD04_09235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLD04_09240	COG1302	Protein conserved in bacteria
CLD04_09245	COG1461	Dihydroxyacetone kinase
CLD04_09250	COG1760	l-serine dehydratase
CLD04_09255	COG1760	l-serine dehydratase
CLD04_09260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLD04_09265	COG2050	protein possibly involved in aromatic compounds catabolism
CLD04_09265	COG1349	DNA-binding transcription factor activity
CLD04_09270	COG0416	fatty acid biosynthetic process
CLD04_09275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLD04_09280	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_09285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLD04_09290	COG0571	ribonuclease III activity
CLD04_09295	COG1196	nuclear chromosome segregation
CLD04_09300	COG0552	protein localization to endoplasmic reticulum
CLD04_09315	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CLD04_09320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLD04_09325	COG0228	four-way junction DNA binding
CLD04_09330	COG1837	Belongs to the UPF0109 family
CLD04_09340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLD04_09345	COG0336	Belongs to the RNA methyltransferase TrmD family
CLD04_09350	COG0335	large ribosomal subunit rRNA binding
CLD04_09355	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CLD04_09360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLD04_09370	COG2257	FlhB HrpN YscU SpaS Family
CLD04_09375	COG0045	succinate-CoA ligase (ADP-forming) activity
CLD04_09380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CLD04_09385	COG0758	DNA mediated transformation
CLD04_09390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLD04_09395	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CLD04_09400	COG4974	Belongs to the 'phage' integrase family
CLD04_09405	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLD04_09410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CLD04_09415	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CLD04_09420	COG1815	bacterial-type flagellum-dependent cell motility
CLD04_09425	COG1558	bacterial-type flagellum-dependent cell motility
CLD04_09430	COG1677	Flagellar hook-basal body complex protein FliE
CLD04_09435	COG1766	The M ring may be actively involved in energy transduction
CLD04_09440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLD04_09445	COG1317	bacterial-type flagellum organization
CLD04_09450	COG1157	protein secretion by the type III secretion system
CLD04_09455	COG2882	bacterial-type flagellum organization
CLD04_09460	COG3334	PFAM MgtE intracellular
CLD04_09465	COG3144	bacterial-type flagellum assembly
CLD04_09470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLD04_09475	COG4786	Flagellar basal body rod
CLD04_09480	COG1582	Flagellar protein (FlbD)
CLD04_09485	COG1580	Controls the rotational direction of flagella during chemotaxis
CLD04_09490	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLD04_09495	COG1776	CheC inhibitor of MCP methylation
CLD04_09495	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLD04_09500	COG2201	protein-glutamate methylesterase activity
CLD04_09505	COG3190	flagellar
CLD04_09510	COG1338	Plays a role in the flagellum-specific transport system
CLD04_09515	COG1987	bacterial-type flagellum assembly
CLD04_09520	COG1684	flagellar biosynthetic protein fliR
CLD04_09525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLD04_09530	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLD04_09535	COG1419	protein localization to endoplasmic reticulum
CLD04_09540	COG0455	bacterial-type flagellum organization
CLD04_09545	COG2201	protein-glutamate methylesterase activity
CLD04_09550	COG0643	Histidine kinase
CLD04_09550	COG2198	Histidine kinase
CLD04_09555	COG0835	chemotaxis
CLD04_09560	COG1776	CheC inhibitor of MCP methylation
CLD04_09565	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CLD04_09570	COG1191	sigma factor activity
CLD04_09580	COG0052	Belongs to the universal ribosomal protein uS2 family
CLD04_09585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLD04_09590	COG0528	UMP kinase activity
CLD04_09595	COG0233	cytoplasmic translational termination
CLD04_09600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLD04_09605	COG4589	Belongs to the CDS family
CLD04_09610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLD04_09615	COG0750	zinc metalloprotease
CLD04_09620	COG0442	prolyl-tRNA aminoacylation
CLD04_09625	COG2176	DNA-directed DNA polymerase activity
CLD04_09630	COG0779	Required for maturation of 30S ribosomal subunits
CLD04_09635	COG0195	Participates in both transcription termination and antitermination
CLD04_09640	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CLD04_09645	COG1358	cellular component organization or biogenesis
CLD04_09650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLD04_09655	COG1550	Protein conserved in bacteria
CLD04_09660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLD04_09665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLD04_09670	COG0196	riboflavin kinase activity
CLD04_09675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLD04_09680	COG1185	polyribonucleotide nucleotidyltransferase activity
CLD04_09685	COG0726	polysaccharide deacetylase
CLD04_09690	COG0612	Peptidase, M16
CLD04_09695	COG1873	PFAM PRC-barrel domain
CLD04_09700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLD04_09705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLD04_09710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLD04_09715	COG0527	aspartate kinase activity
CLD04_09720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLD04_09725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLD04_09730	COG0740	serine-type endopeptidase activity
CLD04_09740	COG1674	ftsk spoiiie
CLD04_09740	COG4980	gas vesicle protein
CLD04_09745	COG2188	Transcriptional regulator
CLD04_09750	COG2814	Major facilitator Superfamily
CLD04_09755	COG0612	Peptidase, M16
CLD04_09760	COG0612	Peptidase, M16
CLD04_09765	COG0300	oxidoreductase activity
CLD04_09780	COG1426	Protein conserved in bacteria
CLD04_09785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLD04_09790	COG1546	Belongs to the CinA family
CLD04_09790	COG1058	Belongs to the CinA family
CLD04_09795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLD04_09800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLD04_09805	COG1418	mRNA catabolic process
CLD04_09810	COG1692	metallophosphoesterase
CLD04_09815	COG2359	stage V sporulation protein S
CLD04_09820	COG1063	alcohol dehydrogenase
CLD04_09825	COG0156	8-amino-7-oxononanoate synthase activity
CLD04_09830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLD04_09835	COG4550	Control of competence regulator ComK, YlbF/YmcA
CLD04_09845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLD04_09850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLD04_09865	COG3226	Transcriptional regulator
CLD04_09875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLD04_09880	COG1404	Belongs to the peptidase S8 family
CLD04_09890	COG4195	phage-related replication protein
CLD04_09895	COG1764	response to oxidative stress
CLD04_09900	COG2076	Multidrug Resistance protein
CLD04_09905	COG2076	Multidrug Resistance protein
CLD04_09920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLD04_09925	COG1923	regulation of RNA biosynthetic process
CLD04_09940	COG1780	Probably involved in ribonucleotide reductase function
CLD04_09945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLD04_09950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLD04_09955	COG4112	unkown
CLD04_09960	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLD04_09970	COG0464	growth
CLD04_09975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLD04_09980	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CLD04_09985	COG0789	Transcriptional regulator
CLD04_09990	COG0174	glutamine synthetase
CLD04_10010	COG5444	nuclease activity
CLD04_10040	COG4282	regulation of fungal-type cell wall biogenesis
CLD04_10055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLD04_10090	COG3655	Transcriptional regulator
CLD04_10115	COG0135	phosphoribosylanthranilate isomerase activity
CLD04_10120	COG2211	Major facilitator Superfamily
CLD04_10125	COG3507	Belongs to the glycosyl hydrolase 43 family
CLD04_10130	COG1940	carbohydrate kinase activity
CLD04_10135	COG2115	Belongs to the xylose isomerase family
CLD04_10140	COG1070	Carbohydrate kinase
CLD04_10155	COG1525	nuclease
CLD04_10160	COG2814	Major facilitator Superfamily
CLD04_10165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLD04_10175	COG0756	dUTP diphosphatase activity
CLD04_10225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLD04_10235	COG3832	glyoxalase III activity
CLD04_10245	COG0697	spore germination
CLD04_10250	COG0531	amino acid
CLD04_10280	COG4195	phage-related replication protein
CLD04_10290	COG0346	lactoylglutathione lyase activity
CLD04_10300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLD04_10305	COG1388	LysM domain
CLD04_10310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLD04_10315	COG4224	UPF0291 protein
CLD04_10320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLD04_10330	COG3763	UPF0154 protein
CLD04_10340	COG0785	Cytochrome C biogenesis protein
CLD04_10345	COG2201	protein-glutamate methylesterase activity
CLD04_10350	COG4846	Membrane protein involved in cytochrome C biogenesis
CLD04_10360	COG0071	Belongs to the small heat shock protein (HSP20) family
CLD04_10375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLD04_10380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLD04_10400	COG0824	Thioesterase
CLD04_10410	COG4841	protein insertion into membrane
CLD04_10415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLD04_10420	COG1832	CoA-binding protein
CLD04_10425	COG0187	DNA topoisomerase II activity
CLD04_10430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLD04_10440	COG1115	amino acid carrier protein
CLD04_10445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLD04_10460	COG3507	Belongs to the glycosyl hydrolase 43 family
CLD04_10465	COG2246	polysaccharide biosynthetic process
CLD04_10470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLD04_10475	COG0586	Pfam SNARE associated Golgi protein
CLD04_10480	COG2404	hydrolase activity, acting on ester bonds
CLD04_10485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLD04_10490	COG1024	Enoyl-CoA hydratase
CLD04_10495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLD04_10500	COG0511	ligase activity, forming carbon-carbon bonds
CLD04_10505	COG0439	Biotin carboxylase
CLD04_10510	COG0318	PFAM AMP-dependent synthetase and ligase
CLD04_10515	COG1960	acyl-CoA dehydrogenase activity
CLD04_10525	COG1649	PFAM Uncharacterised BCR, COG1649
CLD04_10535	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CLD04_10535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLD04_10545	COG2027	D-alanyl-D-alanine carboxypeptidase
CLD04_10550	COG2017	converts alpha-aldose to the beta-anomer
CLD04_10555	COG0534	Mate efflux family protein
CLD04_10570	COG0582	viral genome integration into host DNA
CLD04_10575	COG0166	Belongs to the GPI family
CLD04_10580	COG0405	Gamma-glutamyltransferase
CLD04_10590	COG0493	'glutamate synthase
CLD04_10595	COG0069	glutamate synthase activity
CLD04_10595	COG0070	glutamate synthase
CLD04_10595	COG0067	glutamate synthase
CLD04_10600	COG0583	DNA-binding transcription factor activity
CLD04_10605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CLD04_10610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLD04_10620	COG0300	oxidoreductase activity
CLD04_10625	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CLD04_10635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLD04_10640	COG2814	Major facilitator Superfamily
CLD04_10645	COG1070	Carbohydrate kinase
CLD04_10650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLD04_10655	COG0243	molybdopterin cofactor binding
CLD04_10665	COG2814	Major facilitator Superfamily
CLD04_10670	COG0673	inositol 2-dehydrogenase activity
CLD04_10675	COG1082	Xylose isomerase domain protein TIM barrel
CLD04_10680	COG1609	Transcriptional regulator
CLD04_10700	COG0840	transmembrane signaling receptor activity
CLD04_10700	COG5278	phosphoserine phosphatase activity
CLD04_10705	COG2368	4-hydroxyphenylacetate
CLD04_10710	COG4305	rare lipoprotein A
CLD04_10715	COG3619	membrane
CLD04_10720	COG3866	Pectate lyase
CLD04_10725	COG2135	peptidase activity
CLD04_10755	COG2720	vancomycin resistance protein
CLD04_10765	COG3655	Transcriptional regulator
CLD04_10775	COG0583	DNA-binding transcription factor activity
CLD04_10780	COG0697	spore germination
CLD04_10795	COG0693	protein deglycase activity
CLD04_10800	COG2367	Beta-lactamase
CLD04_10825	COG0574	Belongs to the PEP-utilizing enzyme family
CLD04_10825	COG3848	Pyruvate phosphate dikinase
CLD04_10830	COG0726	polysaccharide deacetylase
CLD04_10840	COG2314	TM2 domain
CLD04_10925	COG0457	Tetratricopeptide repeat
CLD04_10965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLD04_10980	COG5444	nuclease activity
CLD04_10985	COG4282	regulation of fungal-type cell wall biogenesis
CLD04_10990	COG1231	oxidoreductase activity
CLD04_10995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLD04_11000	COG0662	Cupin 2, conserved barrel domain protein
CLD04_11000	COG2207	Transcriptional regulator
CLD04_11005	COG0456	acetyltransferase
CLD04_11010	COG1309	transcriptional regulator
CLD04_11015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLD04_11020	COG3708	Transcriptional regulator
CLD04_11025	COG2378	regulation of single-species biofilm formation
CLD04_11035	COG0640	Transcriptional regulator
CLD04_11040	COG0741	lytic transglycosylase activity
CLD04_11045	COG2322	membrane
CLD04_11060	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLD04_11065	COG3239	Fatty acid desaturase
CLD04_11070	COG4585	Histidine kinase
CLD04_11075	COG2197	response regulator
CLD04_11080	COG3584	3D domain protein
CLD04_11080	COG1388	LysM domain
CLD04_11085	COG0514	ATP-dependent DNA helicase (RecQ)
CLD04_11100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CLD04_11105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLD04_11120	COG0071	Belongs to the small heat shock protein (HSP20) family
CLD04_11145	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_11150	COG1657	PFAM Prenyltransferase squalene oxidase
CLD04_11155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLD04_11160	COG0733	neurotransmitter:sodium symporter activity
CLD04_11165	COG0385	Bile acid
CLD04_11170	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLD04_11175	COG0567	Dehydrogenase, E1 component
CLD04_11180	COG4548	von Willebrand factor, type A
CLD04_11185	COG0714	Associated with various cellular activities
CLD04_11190	COG2032	superoxide dismutase activity
CLD04_11195	COG0791	NLP P60 protein
CLD04_11195	COG1388	LysM domain
CLD04_11200	COG1819	glycosyl
CLD04_11205	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLD04_11210	COG0534	Mate efflux family protein
CLD04_11215	COG1366	Belongs to the anti-sigma-factor antagonist family
CLD04_11220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CLD04_11225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CLD04_11235	COG2962	Rard protein
CLD04_11255	COG1942	4-Oxalocrotonate Tautomerase
CLD04_11260	COG1733	regulation of RNA biosynthetic process
CLD04_11265	COG0778	Nitroreductase
CLD04_11270	COG0400	carboxylic ester hydrolase activity
CLD04_11275	COG0346	lactoylglutathione lyase activity
CLD04_11285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLD04_11295	COG0793	Belongs to the peptidase S41A family
CLD04_11295	COG3409	Peptidoglycan-binding domain 1 protein
CLD04_11300	COG2226	methyltransferase
CLD04_11310	COG1876	peptidase activity
CLD04_11315	COG0813	purine-nucleoside phosphorylase activity
CLD04_11330	COG0671	phosphoesterase, PA-phosphatase related
CLD04_11355	COG4479	Belongs to the UPF0346 family
CLD04_11370	COG0456	acetyltransferase
CLD04_11375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLD04_11380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CLD04_11385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CLD04_11390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLD04_11400	COG0456	acetyltransferase
CLD04_11405	COG0463	Glycosyl transferase, family 2
CLD04_11420	COG4641	Protein conserved in bacteria
CLD04_11425	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
CLD04_11430	COG1086	Polysaccharide biosynthesis protein
CLD04_11435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLD04_11440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLD04_11445	COG1846	Transcriptional regulator
CLD04_11450	COG0534	Mate efflux family protein
CLD04_11460	COG4698	Protein conserved in bacteria
CLD04_11465	COG2755	lipolytic protein G-D-S-L family
CLD04_11470	COG1999	signal sequence binding
CLD04_11480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLD04_11485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLD04_11490	COG1272	protein, Hemolysin III
CLD04_11495	COG0204	Acyl-transferase
CLD04_11500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLD04_11505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLD04_11510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CLD04_11520	COG2521	methyltransferase
CLD04_11520	COG2136	Putative SAM-dependent methyltransferase
CLD04_11530	COG0129	dihydroxy-acid dehydratase activity
CLD04_11535	COG1413	lyase activity
CLD04_11540	COG1418	mRNA catabolic process
CLD04_11545	COG0386	Belongs to the glutathione peroxidase family
CLD04_11550	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CLD04_11555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLD04_11560	COG1278	Cold shock
CLD04_11580	COG0328	RNA-DNA hybrid ribonuclease activity
CLD04_11585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CLD04_11590	COG0328	RNA-DNA hybrid ribonuclease activity
CLD04_11600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLD04_11615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLD04_11625	COG1755	Isoprenylcysteine carboxyl methyltransferase
CLD04_11630	COG3424	synthase
CLD04_11635	COG2233	PERMEase
CLD04_11640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLD04_11645	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CLD04_11655	COG0800	Aldolase
CLD04_11660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLD04_11665	COG1609	Transcriptional regulator
CLD04_11670	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CLD04_11675	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_11680	COG1199	ATP-dependent helicase activity
CLD04_11695	COG0116	Belongs to the methyltransferase superfamily
CLD04_11710	COG4474	Belongs to the UPF0398 family
CLD04_11720	COG3359	exonuclease
CLD04_11725	COG1111	helicase
CLD04_11725	COG1205	dead DEAH box helicase
CLD04_11730	COG2190	(PTS) system
CLD04_11735	COG0071	Belongs to the small heat shock protein (HSP20) family
CLD04_11770	COG3331	DNA recombination
CLD04_11775	COG4499	WXG100 protein secretion system (Wss), protein YukC
CLD04_11775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLD04_11785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLD04_11790	COG3935	DnaD domain protein
CLD04_11795	COG0017	Asparaginyl-tRNA synthetase
CLD04_11800	COG0436	Aminotransferase
CLD04_11805	COG5353	protein conserved in bacteria
CLD04_11815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLD04_11815	COG1199	ATP-dependent helicase activity
CLD04_11820	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLD04_11825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLD04_11830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLD04_11835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLD04_11835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLD04_11840	COG0617	tRNA 3'-terminal CCA addition
CLD04_11845	COG0438	transferase activity, transferring glycosyl groups
CLD04_11850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CLD04_11855	COG1803	Methylglyoxal synthase
CLD04_11860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLD04_11865	COG1694	Mazg nucleotide pyrophosphohydrolase
CLD04_11870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLD04_11880	COG4347	Protein of unknown function (DUF1405)
CLD04_11885	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CLD04_11885	COG2010	Cytochrome c
CLD04_11890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CLD04_11895	COG0723	plastoquinol--plastocyanin reductase activity
CLD04_11905	COG5582	Belongs to the UPF0302 family
CLD04_11910	COG0457	Tetratricopeptide repeat
CLD04_11915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLD04_11920	COG0287	Prephenate dehydrogenase
CLD04_11930	COG0159	tryptophan synthase activity
CLD04_11935	COG0133	tryptophan synthase activity
CLD04_11940	COG0135	phosphoribosylanthranilate isomerase activity
CLD04_11950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLD04_11955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLD04_11960	COG4401	Chorismate mutase type I
CLD04_11965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLD04_11970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLD04_11975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLD04_11980	COG0105	UTP biosynthetic process
CLD04_11985	COG0142	geranyltranstransferase activity
CLD04_11990	COG2226	methyltransferase
CLD04_11995	COG0142	geranyltranstransferase activity
CLD04_12005	COG0302	gtp cyclohydrolase
CLD04_12010	COG0776	regulation of translation
CLD04_12015	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLD04_12030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLD04_12035	COG1160	GTP binding
CLD04_12065	COG1304	FMN binding
CLD04_12070	COG0539	negative regulation of cytoplasmic translation
CLD04_12075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLD04_12085	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CLD04_12090	COG2959	enzyme of heme biosynthesis
CLD04_12095	COG3773	Cell wall hydrolase
CLD04_12095	COG3409	Peptidoglycan-binding domain 1 protein
CLD04_12100	COG2339	peptidase activity
CLD04_12105	COG0492	ferredoxin-NADP+ reductase activity
CLD04_12110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLD04_12115	COG4862	establishment of competence for transformation
CLD04_12120	COG1408	metallophosphoesterase
CLD04_12130	COG1388	LysM domain
CLD04_12135	COG1266	CAAX protease self-immunity
CLD04_12140	COG0514	ATP-dependent DNA helicase (RecQ)
CLD04_12145	COG4955	Helix-turn-helix domain
CLD04_12150	COG1141	Ferredoxin
CLD04_12155	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CLD04_12160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLD04_12165	COG0710	3-dehydroquinate dehydratase activity
CLD04_12175	COG1595	DNA-templated transcription, initiation
CLD04_12180	COG5002	protein histidine kinase activity
CLD04_12185	COG0745	RESPONSE REGULATOR receiver
CLD04_12190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLD04_12195	COG1333	cytochrome c biogenesis protein
CLD04_12200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLD04_12205	COG1187	pseudouridine synthase activity
CLD04_12210	COG0700	Nucleoside recognition
CLD04_12215	COG2715	membrane protein required for spore maturation
CLD04_12220	COG1686	Belongs to the peptidase S11 family
CLD04_12230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLD04_12235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLD04_12240	COG1547	Domain of unknown function (DUF309)
CLD04_12245	COG0456	acetyltransferase
CLD04_12250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLD04_12255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLD04_12255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLD04_12260	COG0307	riboflavin synthase, alpha
CLD04_12265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLD04_12265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLD04_12275	COG0681	Belongs to the peptidase S26 family
CLD04_12285	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CLD04_12295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLD04_12305	COG4086	secreted protein
CLD04_12310	COG0019	diaminopimelate decarboxylase activity
CLD04_12315	COG0697	spore germination
CLD04_12330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLD04_12350	COG1191	sigma factor activity
CLD04_12355	COG2172	sigma factor antagonist activity
CLD04_12360	COG1366	Belongs to the anti-sigma-factor antagonist family
CLD04_12365	COG1686	Belongs to the peptidase S11 family
CLD04_12370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CLD04_12375	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CLD04_12380	COG4974	Belongs to the 'phage' integrase family
CLD04_12390	COG0735	belongs to the Fur family
CLD04_12395	COG1300	Membrane
CLD04_12405	COG0281	malic enzyme
CLD04_12410	COG1757	Na H antiporter
CLD04_12415	COG1027	Aspartate ammonia-lyase
CLD04_12420	COG0252	asparaginase activity
CLD04_12425	COG1396	sequence-specific DNA binding
CLD04_12430	COG1379	DNA repair
CLD04_12435	COG0494	nUDIX hydrolase
CLD04_12445	COG0667	Aldo Keto reductase
CLD04_12455	COG1073	alpha beta
CLD04_12465	COG4918	Iron-sulphur cluster biosynthesis
CLD04_12475	COG2329	Antibiotic biosynthesis monooxygenase
CLD04_12480	COG0456	acetyltransferase
CLD04_12490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLD04_12500	COG2211	Major facilitator Superfamily
CLD04_12510	COG0346	lactoylglutathione lyase activity
CLD04_12515	COG1072	(Pantothenic acid kinase))
CLD04_12520	COG3048	D-serine ammonia-lyase activity
CLD04_12525	COG0300	oxidoreductase activity
CLD04_12530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLD04_12535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLD04_12540	COG4187	Peptidase family M20/M25/M40
CLD04_12545	COG1902	pentaerythritol trinitrate reductase activity
CLD04_12550	COG0596	Alpha beta hydrolase
CLD04_12560	COG1234	tRNA 3'-trailer cleavage
CLD04_12565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CLD04_12570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CLD04_12575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLD04_12585	COG0706	membrane insertase activity
CLD04_12590	COG3361	conserved protein (COG2071)
CLD04_12595	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLD04_12605	COG0346	lactoylglutathione lyase activity
CLD04_12610	COG1376	ErfK ybiS ycfS ynhG family protein
CLD04_12615	COG4129	membrane
CLD04_12620	COG1126	abc transporter atp-binding protein
CLD04_12625	COG0765	amino acid transport
CLD04_12630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLD04_12640	COG1597	lipid kinase activity
CLD04_12645	COG2814	Major facilitator Superfamily
CLD04_12650	COG4978	Transcriptional regulator
CLD04_12650	COG0789	Transcriptional regulator
CLD04_12655	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLD04_12660	COG0022	dehydrogenase e1 component
CLD04_12665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CLD04_12670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLD04_12675	COG3426	butyrate kinase activity
CLD04_12680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLD04_12685	COG0280	phosphate acetyltransferase
CLD04_12690	COG3290	protein histidine kinase activity
CLD04_12690	COG3829	transcription factor binding
CLD04_12700	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CLD04_12705	COG2079	MmgE PrpD family protein
CLD04_12710	COG0372	Belongs to the citrate synthase family
CLD04_12715	COG1960	acyl-CoA dehydrogenase activity
CLD04_12720	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLD04_12725	COG0183	Belongs to the thiolase family
CLD04_12730	COG0584	glycerophosphoryl diester phosphodiesterase
CLD04_12735	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLD04_12745	COG1902	pentaerythritol trinitrate reductase activity
CLD04_12750	COG0745	RESPONSE REGULATOR receiver
CLD04_12755	COG0750	zinc metalloprotease
CLD04_12760	COG0497	DNA recombination
CLD04_12765	COG1438	arginine binding
CLD04_12770	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLD04_12775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLD04_12780	COG0142	geranyltranstransferase activity
CLD04_12785	COG1722	exodeoxyribonuclease VII activity
CLD04_12790	COG1570	exodeoxyribonuclease VII activity
CLD04_12795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLD04_12800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLD04_12805	COG1302	Protein conserved in bacteria
CLD04_12810	COG0439	Biotin carboxylase
CLD04_12815	COG0511	ligase activity, forming carbon-carbon bonds
CLD04_12855	COG3854	ATPases associated with a variety of cellular activities
CLD04_12865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLD04_12870	COG0006	proline dipeptidase activity
CLD04_12875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLD04_12885	COG3872	metal-dependent enzyme
CLD04_12895	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLD04_12900	COG1321	iron dependent repressor
CLD04_12905	COG0095	Lipoate-protein ligase
CLD04_12910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLD04_12915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLD04_12920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLD04_12925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLD04_12930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLD04_12945	COG1396	sequence-specific DNA binding
CLD04_12955	COG0681	Belongs to the peptidase S26 family
CLD04_12980	COG4940	Competence protein ComGF
CLD04_12990	COG4970	Tfp pilus assembly protein FimT
CLD04_12995	COG4537	Required for transformation and DNA binding
CLD04_13000	COG1459	type II secretion system
CLD04_13005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLD04_13015	COG0598	Magnesium transport protein CorA
CLD04_13020	COG1253	flavin adenine dinucleotide binding
CLD04_13025	COG1366	Belongs to the anti-sigma-factor antagonist family
CLD04_13035	COG1393	Belongs to the ArsC family
CLD04_13045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLD04_13055	COG0011	TIGRFAM Protein of
CLD04_13065	COG2866	Carboxypeptidase
CLD04_13070	COG1368	sulfuric ester hydrolase activity
CLD04_13075	COG1940	carbohydrate kinase activity
CLD04_13080	COG4483	Protein conserved in bacteria
CLD04_13085	COG0705	Rhomboid family
CLD04_13085	COG0457	Tetratricopeptide repeat
CLD04_13095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLD04_13100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLD04_13105	COG0438	transferase activity, transferring glycosyl groups
CLD04_13120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLD04_13125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLD04_13130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLD04_13135	COG0581	inorganic phosphate transmembrane transporter activity
CLD04_13140	COG0573	inorganic phosphate transmembrane transporter activity
CLD04_13145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLD04_13155	COG0477	Major facilitator Superfamily
CLD04_13160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLD04_13165	COG2839	Protein conserved in bacteria
CLD04_13170	COG5521	maltodextrose utilization protein MalA
CLD04_13175	COG1388	LysM domain
CLD04_13180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLD04_13185	COG4709	membrane
CLD04_13190	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CLD04_13195	COG0735	belongs to the Fur family
CLD04_13200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLD04_13210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CLD04_13215	COG0513	Belongs to the DEAD box helicase family
CLD04_13225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLD04_13235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CLD04_13240	COG2384	SAM-dependent methyltransferase
CLD04_13245	COG2010	Cytochrome c
CLD04_13255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLD04_13260	COG0358	DNA primase activity
CLD04_13265	COG1671	Belongs to the UPF0178 family
CLD04_13270	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CLD04_13275	COG0517	IMP dehydrogenase activity
CLD04_13280	COG0751	glycine-tRNA ligase activity
CLD04_13285	COG0752	glycyl-tRNA synthetase alpha subunit
CLD04_13290	COG1381	Involved in DNA repair and RecF pathway recombination
CLD04_13300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLD04_13305	COG0295	cytidine deaminase activity
CLD04_13310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLD04_13315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLD04_13320	COG1480	7TM receptor with intracellular HD hydrolase
CLD04_13325	COG1702	phosphate starvation-inducible protein PhoH
CLD04_13330	COG0561	phosphatase activity
CLD04_13345	COG4864	UPF0365 protein
CLD04_13350	COG1030	water channel activity
CLD04_13355	COG1610	YqeY-like protein
CLD04_13360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLD04_13365	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLD04_13370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLD04_13375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLD04_13380	COG2264	protein methyltransferase activity
CLD04_13385	COG0484	heat shock protein binding
CLD04_13390	COG0443	Heat shock 70 kDa protein
CLD04_13395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLD04_13400	COG1420	regulation of RNA biosynthetic process
CLD04_13405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLD04_13410	COG0481	GTPase activity
CLD04_13420	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLD04_13425	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CLD04_13430	COG0268	Binds directly to 16S ribosomal RNA
CLD04_13435	COG1466	dna polymerase III delta subunit
CLD04_13445	COG0658	competence protein
CLD04_13445	COG2333	competence protein COMEC
CLD04_13450	COG2131	deaminase
CLD04_13455	COG1596	polysaccharide export
CLD04_13455	COG1555	photosystem II stabilization
CLD04_13460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLD04_13465	COG2226	methyltransferase
CLD04_13470	COG0799	negative regulation of ribosome biogenesis
CLD04_13475	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLD04_13480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLD04_13485	COG1534	Rna-binding protein
CLD04_13490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLD04_13495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CLD04_13500	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CLD04_13510	COG2755	lipolytic protein G-D-S-L family
CLD04_13520	COG0398	Pfam SNARE associated Golgi protein
CLD04_13525	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CLD04_13535	COG3209	COG3209 Rhs family protein
CLD04_13555	COG4124	Belongs to the glycosyl hydrolase 26 family
CLD04_13560	COG0730	response to heat
CLD04_13565	COG0425	Belongs to the sulfur carrier protein TusA family
CLD04_13580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLD04_13580	COG0425	Belongs to the sulfur carrier protein TusA family
CLD04_13590	COG2210	Belongs to the sulfur carrier protein TusA family
CLD04_13595	COG1937	Protein conserved in bacteria
CLD04_13610	COG0662	Cupin 2, conserved barrel domain protein
CLD04_13625	COG0789	Transcriptional regulator
CLD04_13625	COG4978	Transcriptional regulator
CLD04_13630	COG2814	Major facilitator Superfamily
CLD04_13635	COG0456	acetyltransferase
CLD04_13640	COG1253	flavin adenine dinucleotide binding
CLD04_13650	COG0697	spore germination
CLD04_13655	COG0583	DNA-binding transcription factor activity
CLD04_13660	COG2072	flavoprotein involved in K transport
CLD04_13665	COG1230	cation diffusion facilitator family transporter
CLD04_13670	COG1942	4-Oxalocrotonate Tautomerase
CLD04_13675	COG0583	DNA-binding transcription factor activity
CLD04_13690	COG1687	branched-chain amino acid
CLD04_13695	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CLD04_13700	COG1522	sequence-specific DNA binding
CLD04_13705	COG2732	(Barnase) inhibitor
CLD04_13710	COG2124	cytochrome p450
CLD04_13720	COG1335	isochorismatase
CLD04_13735	COG2318	DinB family
CLD04_13745	COG2070	2-Nitropropane dioxygenase
CLD04_13760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLD04_13775	COG3443	Belongs to the bacterial solute-binding protein 9 family
CLD04_13780	COG1595	DNA-templated transcription, initiation
CLD04_13785	COG0667	Aldo Keto reductase
CLD04_13790	COG2851	Citrate transporter
CLD04_13795	COG0583	DNA-binding transcription factor activity
CLD04_13800	COG2828	Protein conserved in bacteria
CLD04_13810	COG5566	PFAM Mor transcription activator
CLD04_13815	COG0596	Alpha beta hydrolase
CLD04_13820	COG4991	sh3 domain protein
CLD04_13825	COG4991	sh3 domain protein
CLD04_13830	COG0346	lactoylglutathione lyase activity
CLD04_13840	COG5577	PFAM Coat F domain
CLD04_13845	COG1063	alcohol dehydrogenase
CLD04_13855	COG5577	PFAM Coat F domain
CLD04_13860	COG0789	Transcriptional regulator
CLD04_13865	COG1064	alcohol dehydrogenase
CLD04_13870	COG0693	protein deglycase activity
CLD04_13875	COG1621	beta-fructofuranosidase activity
CLD04_13880	COG3716	PTS system mannose fructose sorbose family IID component
CLD04_13885	COG3715	PTS system
CLD04_13890	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_13895	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLD04_13900	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLD04_13900	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLD04_13905	COG1113	amino acid transport
CLD04_13910	COG1280	lysine exporter protein (LysE YggA)
CLD04_13915	COG1378	Sugar-specific transcriptional regulator TrmB
CLD04_13920	COG1595	DNA-templated transcription, initiation
CLD04_13930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CLD04_13930	COG2755	lipolytic protein G-D-S-L family
CLD04_13940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CLD04_13940	COG2124	cytochrome p450
CLD04_13945	COG1309	transcriptional regulator
CLD04_13950	COG2226	methyltransferase
CLD04_13960	COG2116	formate transmembrane transporter activity
CLD04_13965	COG5609	conserved protein (DUF2294)
CLD04_13970	COG3383	formate dehydrogenase (NAD+) activity
CLD04_13975	COG2427	Protein of unknown function (DUF1641)
CLD04_13985	COG0626	cystathionine gamma-synthase activity
CLD04_13990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLD04_13995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLD04_14000	COG2226	methyltransferase
CLD04_14015	COG0768	penicillin binding
CLD04_14020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLD04_14025	COG0572	uridine kinase
CLD04_14045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLD04_14050	COG3906	Belongs to the UPF0473 family
CLD04_14055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLD04_14060	COG4472	Bacterial protein of unknown function (DUF965)
CLD04_14065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLD04_14070	COG0628	permease
CLD04_14075	COG1126	abc transporter atp-binding protein
CLD04_14080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLD04_14085	COG0765	amino acid transport
CLD04_14090	COG0765	amino acid transport
CLD04_14105	COG3881	PFAM PRC-barrel domain
CLD04_14110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLD04_14115	COG0457	Tetratricopeptide repeat
CLD04_14120	COG0482	sulfurtransferase activity
CLD04_14125	COG1104	cysteine desulfurase activity
CLD04_14130	COG1959	2 iron, 2 sulfur cluster binding
CLD04_14135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLD04_14140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLD04_14150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLD04_14155	COG0124	histidyl-tRNA synthetase
CLD04_14165	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLD04_14165	COG3103	Sh3 type 3 domain protein
CLD04_14165	COG4991	sh3 domain protein
CLD04_14170	COG1490	D-aminoacyl-tRNA deacylase activity
CLD04_14175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLD04_14180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLD04_14185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLD04_14185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLD04_14190	COG5416	Lipopolysaccharide assembly protein A domain
CLD04_14195	COG0490	domain, Protein
CLD04_14200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLD04_14200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLD04_14210	COG2244	polysaccharide biosynthetic process
CLD04_14215	COG2323	membrane
CLD04_14230	COG1862	Preprotein translocase
CLD04_14235	COG0343	queuine tRNA-ribosyltransferase activity
CLD04_14240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLD04_14250	COG2255	four-way junction helicase activity
CLD04_14255	COG0632	four-way junction helicase activity
CLD04_14265	COG2814	Major facilitator Superfamily
CLD04_14270	COG0673	inositol 2-dehydrogenase activity
CLD04_14290	COG1115	amino acid carrier protein
CLD04_14295	COG0217	transcriptional regulatory protein
CLD04_14305	COG1388	LysM domain
CLD04_14310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CLD04_14315	COG0157	Belongs to the NadC ModD family
CLD04_14320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CLD04_14325	COG1104	cysteine desulfurase activity
CLD04_14330	COG1827	regulation of RNA biosynthetic process
CLD04_14335	COG0077	Prephenate dehydratase
CLD04_14340	COG4492	Belongs to the UPF0735 family
CLD04_14345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLD04_14350	COG3290	protein histidine kinase activity
CLD04_14355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLD04_14360	COG2868	ribosomal protein
CLD04_14365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLD04_14370	COG1994	Peptidase M50
CLD04_14375	COG0739	heme binding
CLD04_14380	COG2894	cell division
CLD04_14385	COG0850	regulation of cytokinetic process
CLD04_14390	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CLD04_14395	COG1792	Involved in formation and maintenance of cell shape
CLD04_14400	COG1077	Cell shape determining protein MreB Mrl
CLD04_14405	COG2003	Belongs to the UPF0758 family
CLD04_14410	COG0424	maF-like protein
CLD04_14420	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLD04_14425	COG0285	dihydrofolate synthase activity
CLD04_14430	COG0525	valine-tRNA ligase activity
CLD04_14440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLD04_14445	COG1388	LysM domain
CLD04_14450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLD04_14455	COG0113	porphobilinogen synthase activity
CLD04_14460	COG1587	Uroporphyrinogen-III synthase
CLD04_14465	COG0181	hydroxymethylbilane synthase activity
CLD04_14470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLD04_14475	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLD04_14485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLD04_14490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLD04_14495	COG1067	ATP-dependent peptidase activity
CLD04_14495	COG0470	DNA polymerase III
CLD04_14500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLD04_14505	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLD04_14510	COG1477	protein flavinylation
CLD04_14510	COG0457	Tetratricopeptide repeat
CLD04_14515	COG0066	3-isopropylmalate dehydratase activity
CLD04_14520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLD04_14525	COG0473	3-isopropylmalate dehydrogenase activity
CLD04_14530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLD04_14535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLD04_14540	COG0440	acetolactate synthase activity
CLD04_14545	COG0028	Belongs to the TPP enzyme family
CLD04_14560	COG0454	-acetyltransferase
CLD04_14565	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CLD04_14575	COG0622	Phosphoesterase
CLD04_14580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLD04_14585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CLD04_14590	COG5401	PFAM Sporulation and spore germination
CLD04_14595	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLD04_14600	COG1846	Transcriptional regulator
CLD04_14605	COG2197	response regulator
CLD04_14610	COG0824	Thioesterase
CLD04_14620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CLD04_14625	COG1053	succinate dehydrogenase
CLD04_14630	COG2009	succinate dehydrogenase
CLD04_14635	COG1719	4-vinyl reductase, 4VR
CLD04_14640	COG0527	aspartate kinase activity
CLD04_14650	COG0322	excinuclease ABC activity
CLD04_14655	COG3118	belongs to the thioredoxin family
CLD04_14660	COG3534	alpha-L-arabinofuranosidase
CLD04_14665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLD04_14670	COG2086	electron transfer activity
CLD04_14675	COG1024	Enoyl-CoA hydratase
CLD04_14680	COG1309	transcriptional regulator
CLD04_14685	COG0318	PFAM AMP-dependent synthetase and ligase
CLD04_14690	COG3766	membrane
CLD04_14695	COG1193	negative regulation of DNA recombination
CLD04_14700	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLD04_14700	COG1796	DNA polymerase
CLD04_14705	COG1286	toxin biosynthetic process
CLD04_14710	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CLD04_14715	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLD04_14720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLD04_14720	COG0072	phenylalanine-tRNA ligase activity
CLD04_14725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLD04_14735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLD04_14745	COG3835	regulator
CLD04_14750	COG0277	FAD linked oxidase domain protein
CLD04_14755	COG0247	lactate metabolic process
CLD04_14760	COG0346	lactoylglutathione lyase activity
CLD04_14770	COG1966	Carbon starvation protein
CLD04_14775	COG3534	alpha-L-arabinofuranosidase
CLD04_14780	COG0395	ABC-type sugar transport system, permease component
CLD04_14785	COG1175	transmembrane transport
CLD04_14790	COG1653	transport
CLD04_14795	COG0371	Dehydrogenase
CLD04_14800	COG0647	UMP catabolic process
CLD04_14805	COG0235	Class ii aldolase
CLD04_14810	COG1069	ribulokinase activity
CLD04_14815	COG2160	L-arabinose isomerase activity
CLD04_14825	COG3507	Belongs to the glycosyl hydrolase 43 family
CLD04_14830	COG1363	Peptidase, m42
CLD04_14840	COG3326	Membrane
CLD04_14845	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLD04_14850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLD04_14855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLD04_14865	COG1346	cytolysis
CLD04_14870	COG1380	Effector of murein hydrolase LrgA
CLD04_14875	COG3279	Response regulator of the LytR AlgR family
CLD04_14880	COG3275	phosphorelay sensor kinase activity
CLD04_14890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLD04_14900	COG0398	Pfam SNARE associated Golgi protein
CLD04_14905	COG1484	DNA-dependent DNA replication
CLD04_14910	COG3611	Membrane attachment protein
CLD04_14915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLD04_14920	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CLD04_14925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLD04_14940	COG0656	L-ascorbic acid biosynthetic process
CLD04_14945	COG0237	dephospho-CoA kinase activity
CLD04_14950	COG1971	Probably functions as a manganese efflux pump
CLD04_14955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CLD04_14960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLD04_14960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLD04_14965	COG5002	protein histidine kinase activity
CLD04_14970	COG0745	RESPONSE REGULATOR receiver
CLD04_14975	COG0039	L-malate dehydrogenase activity
CLD04_14980	COG0538	isocitrate dehydrogenase activity
CLD04_14985	COG0372	Belongs to the citrate synthase family
CLD04_14990	COG2707	UPF0756 membrane protein
CLD04_14995	COG0628	permease
CLD04_15000	COG3030	protein affecting phage T7 exclusion by the F plasmid
CLD04_15005	COG0469	pyruvate kinase activity
CLD04_15010	COG0205	6-phosphofructokinase activity
CLD04_15015	COG0825	malonyl-CoA metabolic process
CLD04_15020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLD04_15025	COG0281	malic enzyme
CLD04_15030	COG0587	DNA-directed DNA polymerase activity
CLD04_15050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLD04_15060	COG4109	DRTGG domain
CLD04_15065	COG0730	response to heat
CLD04_15075	COG0196	riboflavin kinase activity
CLD04_15080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLD04_15085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CLD04_15090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLD04_15095	COG1126	abc transporter atp-binding protein
CLD04_15100	COG0765	amino acid transport
CLD04_15105	COG0765	amino acid transport
CLD04_15110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLD04_15115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLD04_15120	COG0454	-acetyltransferase
CLD04_15125	COG0583	DNA-binding transcription factor activity
CLD04_15130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLD04_15135	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_15145	COG0165	Argininosuccinate lyase
CLD04_15150	COG0137	argininosuccinate synthase activity
CLD04_15155	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLD04_15160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLD04_15165	COG0827	DNA restriction-modification system
CLD04_15170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLD04_15175	COG3874	Sporulation protein YtfJ
CLD04_15185	COG1714	RDD family
CLD04_15190	COG0616	signal peptide processing
CLD04_15195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLD04_15200	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CLD04_15205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLD04_15215	COG0301	tRNA thio-modification
CLD04_15220	COG1104	cysteine desulfurase activity
CLD04_15225	COG1114	Component of the transport system for branched-chain amino acids
CLD04_15230	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CLD04_15235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLD04_15240	COG1309	transcriptional regulator
CLD04_15245	COG1956	GAF domain-containing protein
CLD04_15250	COG2203	Gaf domain
CLD04_15250	COG2199	diguanylate cyclase activity
CLD04_15260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLD04_15270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLD04_15280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLD04_15285	COG0454	-acetyltransferase
CLD04_15290	COG0517	IMP dehydrogenase activity
CLD04_15295	COG0123	including yeast histone deacetylase and acetoin utilization protein
CLD04_15300	COG1360	Flagellar Motor Protein
CLD04_15305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLD04_15310	COG1609	Transcriptional regulator
CLD04_15315	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLD04_15315	COG1605	Chorismate mutase
CLD04_15320	COG3118	belongs to the thioredoxin family
CLD04_15325	COG4980	gas vesicle protein
CLD04_15330	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CLD04_15335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLD04_15340	COG1674	ftsk spoiiie
CLD04_15345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLD04_15350	COG4848	Belongs to the UPF0354 family
CLD04_15355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLD04_15365	COG1363	Peptidase, m42
CLD04_15370	COG5584	Small secreted protein
CLD04_15375	COG0281	malic enzyme
CLD04_15380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLD04_15385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLD04_15395	COG0510	thiamine kinase activity
CLD04_15400	COG1523	belongs to the glycosyl hydrolase 13 family
CLD04_15405	COG1597	lipid kinase activity
CLD04_15415	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CLD04_15420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLD04_15430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLD04_15435	COG2252	PERMEase
CLD04_15440	COG4473	ABC transporter
CLD04_15445	COG1131	(ABC) transporter
CLD04_15450	COG1349	DNA-binding transcription factor activity
CLD04_15455	COG1187	pseudouridine synthase activity
CLD04_15460	COG2244	polysaccharide biosynthetic process
CLD04_15465	COG2081	HI0933 family
CLD04_15470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLD04_15480	COG5578	integral membrane protein
CLD04_15485	COG0673	inositol 2-dehydrogenase activity
CLD04_15490	COG1653	transport
CLD04_15495	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CLD04_15500	COG4209	transmembrane transport
CLD04_15510	COG1653	transport
CLD04_15515	COG0395	ABC-type sugar transport system, permease component
CLD04_15520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLD04_15525	COG2124	cytochrome p450
CLD04_15530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLD04_15540	COG0156	8-amino-7-oxononanoate synthase activity
CLD04_15545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLD04_15555	COG1073	alpha beta
CLD04_15580	COG1486	melibiose metabolic process
CLD04_15585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLD04_15590	COG0495	leucyl-tRNA aminoacylation
CLD04_15600	COG2202	Pas domain
CLD04_15600	COG1366	Belongs to the anti-sigma-factor antagonist family
CLD04_15605	COG2814	Major facilitator Superfamily
CLD04_15610	COG2433	Pfam Transposase IS66
CLD04_15615	COG0577	efflux transmembrane transporter activity
CLD04_15620	COG1136	(ABC) transporter
CLD04_15625	COG2205	protein histidine kinase activity
CLD04_15630	COG0745	RESPONSE REGULATOR receiver
CLD04_15635	COG0577	efflux transmembrane transporter activity
CLD04_15640	COG1136	(ABC) transporter
CLD04_15655	COG1131	(ABC) transporter
CLD04_15660	COG1725	Transcriptional regulator
CLD04_15670	COG1242	4 iron, 4 sulfur cluster binding
CLD04_15675	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CLD04_15685	COG2267	carboxylic ester hydrolase activity
CLD04_15690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CLD04_15700	COG0367	asparagine synthase
CLD04_15705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLD04_15710	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CLD04_15725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLD04_15730	COG1116	anion transmembrane transporter activity
CLD04_15735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLD04_15740	COG0494	nUDIX hydrolase
CLD04_15745	COG4824	toxin secretion phage lysis holin
CLD04_15750	COG0783	Belongs to the Dps family
CLD04_15765	COG1854	S-ribosylhomocysteine lyase activity
CLD04_15770	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLD04_15775	COG0288	reversible hydration of carbon dioxide
CLD04_15780	COG0254	rRNA binding
CLD04_15785	COG1271	oxidase subunit
CLD04_15790	COG1294	oxidase, subunit
CLD04_15800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLD04_15805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLD04_15805	COG1321	iron dependent repressor
CLD04_15810	COG1121	(ABC) transporter
CLD04_15815	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLD04_15825	COG4948	Mandelate Racemase Muconate Lactonizing
CLD04_15830	COG0318	PFAM AMP-dependent synthetase and ligase
CLD04_15835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CLD04_15840	COG0596	Alpha beta hydrolase
CLD04_15845	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CLD04_15850	COG1169	isochorismate synthase
CLD04_15855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLD04_15860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLD04_15865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CLD04_15870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLD04_15875	COG0438	transferase activity, transferring glycosyl groups
CLD04_15885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLD04_15890	COG0438	transferase activity, transferring glycosyl groups
CLD04_15895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLD04_15900	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CLD04_15905	COG0058	SHG alpha-glucan phosphorylase activity
CLD04_15910	COG0297	glycogen (starch) synthase activity
CLD04_15915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLD04_15920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLD04_15925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLD04_16050	COG3859	Proton-coupled thiamine transporter YuaJ
CLD04_16055	COG1247	-acetyltransferase
CLD04_16060	COG2268	Band 7 protein
CLD04_16065	COG1585	Membrane protein implicated in regulation of membrane protease activity
CLD04_16070	COG2318	DinB family
CLD04_16080	COG1454	alcohol dehydrogenase
CLD04_16090	COG1510	regulation of RNA biosynthetic process
CLD04_16105	COG0569	domain protein
CLD04_16110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLD04_16115	COG4682	membrane
CLD04_16120	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLD04_16125	COG0477	Major facilitator Superfamily
CLD04_16130	COG5553	Cysteine dioxygenase type I
CLD04_16140	COG1968	undecaprenyl-diphosphatase activity
CLD04_16145	COG0628	permease
CLD04_16150	COG0673	inositol 2-dehydrogenase activity
CLD04_16155	COG4806	L-rhamnose isomerase
CLD04_16160	COG3254	rhamnose metabolic process
CLD04_16165	COG1070	Carbohydrate kinase
CLD04_16170	COG1349	DNA-binding transcription factor activity
CLD04_16175	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_16175	COG3347	Dehydrogenase
CLD04_16185	COG0840	transmembrane signaling receptor activity
CLD04_16190	COG0840	transmembrane signaling receptor activity
CLD04_16195	COG0840	transmembrane signaling receptor activity
CLD04_16200	COG0840	transmembrane signaling receptor activity
CLD04_16215	COG0432	Pfam Uncharacterised protein family UPF0047
CLD04_16220	COG0366	Alpha amylase catalytic
CLD04_16225	COG1253	flavin adenine dinucleotide binding
CLD04_16230	COG2738	Putative neutral zinc metallopeptidase
CLD04_16245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CLD04_16260	COG0166	Belongs to the GPI family
CLD04_16265	COG1979	alcohol dehydrogenase
CLD04_16270	COG1979	alcohol dehydrogenase
CLD04_16275	COG2155	Conserved Protein
CLD04_16280	COG1098	S1 RNA binding domain
CLD04_16285	COG0436	Aminotransferase
CLD04_16290	COG1522	sequence-specific DNA binding
CLD04_16295	COG2267	carboxylic ester hydrolase activity
CLD04_16305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLD04_16310	COG2205	protein histidine kinase activity
CLD04_16320	COG5018	Exonuclease
CLD04_16330	COG2814	Major facilitator Superfamily
CLD04_16335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLD04_16340	COG3011	Protein conserved in bacteria
CLD04_16350	COG3290	protein histidine kinase activity
CLD04_16355	COG4565	transcriptional regulatory protein
CLD04_16380	COG3493	citrate carrier protein
CLD04_16390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLD04_16390	COG2111	Na H antiporter
CLD04_16395	COG2111	Na H antiporter
CLD04_16400	COG1006	Multisubunit Na H antiporter MnhC subunit
CLD04_16405	COG0651	ATP synthesis coupled electron transport
CLD04_16410	COG1863	multisubunit Na H antiporter MnhE subunit
CLD04_16415	COG2212	antiporter activity
CLD04_16420	COG1320	monovalent cation:proton antiporter activity
CLD04_16425	COG2050	protein possibly involved in aromatic compounds catabolism
CLD04_16430	COG2197	response regulator
CLD04_16445	COG0142	geranyltranstransferase activity
CLD04_16460	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CLD04_16465	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLD04_16470	COG1335	isochorismatase
CLD04_16475	COG5506	Protein of unknown function (DUF1694)
CLD04_16490	COG0628	permease
CLD04_16505	COG1418	mRNA catabolic process
CLD04_16510	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_16520	COG1511	domain protein
CLD04_16525	COG0433	COG0433 Predicted ATPase
CLD04_16525	COG1674	ftsk spoiiie
CLD04_16530	COG4499	WXG100 protein secretion system (Wss), protein YukC
CLD04_16535	COG5417	Belongs to the EsaB family
CLD04_16540	COG4842	Belongs to the WXG100 family
CLD04_16550	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CLD04_16550	COG2508	Transcriptional regulator
CLD04_16555	COG0686	Belongs to the AlaDH PNT family
CLD04_16560	COG5634	Uncharacterized conserved protein (DUF2278)
CLD04_16565	COG3251	PFAM MbtH domain protein
CLD04_16570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLD04_16575	COG1535	isochorismatase
CLD04_16575	COG3433	isochorismatase activity
CLD04_16580	COG1021	2,3-dihydroxybenzoate-AMP ligase
CLD04_16585	COG1169	isochorismate synthase
CLD04_16590	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_16595	COG2819	hydrolase of the alpha beta superfamily
CLD04_16600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CLD04_16605	COG1268	BioY protein
CLD04_16610	COG2056	Na+-H+ antiporter family
CLD04_16615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLD04_16620	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CLD04_16625	COG3584	3D domain protein
CLD04_16640	COG1252	NADH dehydrogenase
CLD04_16645	COG0492	ferredoxin-NADP+ reductase activity
CLD04_16655	COG0516	GMP reductase activity
CLD04_16660	COG2808	Putative FMN-binding domain
CLD04_16665	COG0456	acetyltransferase
CLD04_16670	COG0316	Belongs to the HesB IscA family
CLD04_16675	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLD04_16680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLD04_16685	COG4844	belongs to the
CLD04_16690	COG1252	NADH dehydrogenase
CLD04_16695	COG4837	Protein of unknown function (DUF1462)
CLD04_16700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CLD04_16705	COG0823	Involved in the tonB-independent uptake of proteins
CLD04_16705	COG1506	peptidase
CLD04_16705	COG4946	Tricorn protease homolog
CLD04_16710	COG0083	homoserine kinase activity
CLD04_16715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CLD04_16720	COG0460	homoserine dehydrogenase
CLD04_16725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLD04_16730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CLD04_16735	COG0647	UMP catabolic process
CLD04_16740	COG2445	Protein of unknown function DUF86
CLD04_16745	COG4470	Protein conserved in bacteria
CLD04_16755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CLD04_16760	COG0739	heme binding
CLD04_16770	COG3377	Domain of unknown function (DUF1805)
CLD04_16775	COG0737	Belongs to the 5'-nucleotidase family
CLD04_16780	COG0730	response to heat
CLD04_16785	COG1801	Protein of unknown function DUF72
CLD04_16795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLD04_16800	COG2508	Transcriptional regulator
CLD04_16805	COG2233	PERMEase
CLD04_16810	COG2233	PERMEase
CLD04_16815	COG3195	allantoin biosynthetic process
CLD04_16815	COG3648	Uricase
CLD04_16820	COG2351	hydroxyisourate hydrolase activity
CLD04_16830	COG2080	2 iron, 2 sulfur cluster binding
CLD04_16835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLD04_16840	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CLD04_16845	COG2068	MobA-Related Protein
CLD04_16850	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLD04_16855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLD04_16860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLD04_16865	COG2356	endonuclease I
CLD04_16880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLD04_16890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLD04_16890	COG0072	phenylalanine-tRNA ligase activity
CLD04_16905	COG3842	ATPase activity
CLD04_16910	COG2188	Transcriptional regulator
CLD04_16925	COG1653	transport
CLD04_16930	COG2222	sugar isomerase
CLD04_16935	COG0322	excinuclease ABC activity
CLD04_16940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLD04_16960	COG0719	Fe-S assembly protein
CLD04_16965	COG0822	iron-sulfur transferase activity
CLD04_16970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLD04_16975	COG0719	Fe-S assembly protein
CLD04_16980	COG0396	ATPase activity
CLD04_16995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLD04_17000	COG1464	Belongs to the NlpA lipoprotein family
CLD04_17005	COG2011	ABC-type metal ion transport system permease component
CLD04_17010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLD04_17020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLD04_17025	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CLD04_17035	COG0509	glycine decarboxylation via glycine cleavage system
CLD04_17040	COG1393	Belongs to the ArsC family
CLD04_17045	COG1960	acyl-CoA dehydrogenase activity
CLD04_17050	COG0183	Belongs to the thiolase family
CLD04_17055	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLD04_17055	COG1024	Enoyl-CoA hydratase
CLD04_17065	COG0506	proline dehydrogenase activity
CLD04_17075	COG5577	PFAM Coat F domain
CLD04_17080	COG1846	Transcriptional regulator
CLD04_17085	COG0477	Major facilitator Superfamily
CLD04_17090	COG1942	4-Oxalocrotonate Tautomerase
CLD04_17095	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_17100	COG0583	DNA-binding transcription factor activity
CLD04_17110	COG1120	ATPase activity
CLD04_17125	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_17130	COG0783	Belongs to the Dps family
CLD04_17135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLD04_17140	COG0745	RESPONSE REGULATOR receiver
CLD04_17145	COG2770	Histidine kinase
CLD04_17145	COG2205	protein histidine kinase activity
CLD04_17155	COG1309	transcriptional regulator
CLD04_17160	COG0114	fumarate hydratase activity
CLD04_17170	COG0697	spore germination
CLD04_17175	COG0814	amino acid
CLD04_17185	COG2197	response regulator
CLD04_17190	COG4585	Histidine kinase
CLD04_17195	COG4758	membrane
CLD04_17200	COG3595	metallopeptidase activity
CLD04_17205	COG1842	Phage shock protein A
CLD04_17210	COG4758	membrane
CLD04_17215	COG2814	Major facilitator Superfamily
CLD04_17220	COG2096	Adenosyltransferase
CLD04_17225	COG1120	ATPase activity
CLD04_17230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_17235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLD04_17240	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_17245	COG3386	PFAM SMP-30 Gluconolaconase
CLD04_17250	COG2205	protein histidine kinase activity
CLD04_17255	COG0745	RESPONSE REGULATOR receiver
CLD04_17265	COG1191	sigma factor activity
CLD04_17275	COG2140	Oxalate decarboxylase
CLD04_17285	COG0577	efflux transmembrane transporter activity
CLD04_17290	COG1136	(ABC) transporter
CLD04_17295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLD04_17300	COG1120	ATPase activity
CLD04_17305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_17310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLD04_17315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLD04_17325	COG0531	amino acid
CLD04_17340	COG1988	membrane-bound metal-dependent
CLD04_17345	COG1368	sulfuric ester hydrolase activity
CLD04_17350	COG1910	domain protein
CLD04_17355	COG0725	ABC transporter, periplasmic molybdate-binding protein
CLD04_17360	COG4149	molybdate abc transporter
CLD04_17365	COG0656	L-ascorbic acid biosynthetic process
CLD04_17375	COG0025	NhaP-type Na H and K H
CLD04_17380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLD04_17385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CLD04_17390	COG3973	AAA domain
CLD04_17395	COG2860	membrane
CLD04_17400	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CLD04_17405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLD04_17410	COG2217	Heavy metal translocating P-type atpase
CLD04_17415	COG2217	Heavy metal translocating P-type atpase
CLD04_17420	COG2608	mercury ion transmembrane transporter activity
CLD04_17425	COG1937	Protein conserved in bacteria
CLD04_17430	COG0673	inositol 2-dehydrogenase activity
CLD04_17435	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CLD04_17440	COG1289	transmembrane transporter activity
CLD04_17450	COG2076	Multidrug Resistance protein
CLD04_17455	COG1309	transcriptional regulator
CLD04_17460	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_17470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLD04_17475	COG0557	exoribonuclease II activity
CLD04_17480	COG1647	Serine aminopeptidase, S33
CLD04_17485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLD04_17490	COG0596	Alpha beta hydrolase
CLD04_17495	COG1476	TRANSCRIPTIONal
CLD04_17500	COG1396	sequence-specific DNA binding
CLD04_17505	COG1396	sequence-specific DNA binding
CLD04_17510	COG1733	regulation of RNA biosynthetic process
CLD04_17515	COG0840	transmembrane signaling receptor activity
CLD04_17520	COG1174	glycine betaine transport
CLD04_17525	COG1732	Glycine betaine
CLD04_17530	COG1174	glycine betaine transport
CLD04_17535	COG0517	IMP dehydrogenase activity
CLD04_17535	COG1125	glycine betaine transport
CLD04_17540	COG1510	regulation of RNA biosynthetic process
CLD04_17560	COG5658	integral membrane protein
CLD04_17565	COG0640	Transcriptional regulator
CLD04_17570	COG1174	glycine betaine transport
CLD04_17575	COG1732	Glycine betaine
CLD04_17580	COG1174	glycine betaine transport
CLD04_17585	COG1125	glycine betaine transport
CLD04_17585	COG0517	IMP dehydrogenase activity
CLD04_17590	COG1510	regulation of RNA biosynthetic process
CLD04_17595	COG2095	MarC family integral membrane protein
CLD04_17605	COG3064	Membrane
CLD04_17610	COG4640	response to antibiotic
CLD04_17615	COG0456	acetyltransferase
CLD04_17620	COG0148	phosphopyruvate hydratase activity
CLD04_17625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CLD04_17630	COG0149	triose-phosphate isomerase activity
CLD04_17635	COG0126	phosphoglycerate kinase activity
CLD04_17640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLD04_17645	COG2390	Transcriptional regulator
CLD04_17650	COG2814	Major facilitator Superfamily
CLD04_17655	COG1609	Transcriptional regulator
CLD04_17660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLD04_17670	COG0583	DNA-binding transcription factor activity
CLD04_17675	COG0697	spore germination
CLD04_17680	COG1113	amino acid transport
CLD04_17685	COG3858	chitin binding
CLD04_17690	COG1556	Lactate utilization protein
CLD04_17695	COG1139	Iron-sulfur cluster binding protein
CLD04_17700	COG0247	lactate metabolic process
CLD04_17730	COG4585	Histidine kinase
CLD04_17735	COG0842	Transport permease protein
CLD04_17740	COG1131	(ABC) transporter
CLD04_17745	COG0596	Alpha beta hydrolase
CLD04_17750	COG2208	phosphoserine phosphatase activity
CLD04_17755	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CLD04_17760	COG1874	Beta-galactosidase
CLD04_17765	COG3833	ABC-type maltose transport systems, permease component
CLD04_17770	COG1175	transmembrane transport
CLD04_17775	COG2182	Extracellular solute-binding protein
CLD04_17780	COG1609	Transcriptional regulator
CLD04_17785	COG2186	Transcriptional regulator
CLD04_17790	COG1620	l-lactate permease
CLD04_17795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLD04_17805	COG5039	Polysaccharide pyruvyl transferase
CLD04_17810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLD04_17815	COG0110	maltose O-acetyltransferase activity
CLD04_17820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLD04_17825	COG2244	polysaccharide biosynthetic process
CLD04_17830	COG1216	Glycosyl transferase, family 2
CLD04_17835	COG5039	Polysaccharide pyruvyl transferase
CLD04_17840	COG1216	Glycosyl transferase, family 2
CLD04_17850	COG0438	transferase activity, transferring glycosyl groups
CLD04_17855	COG1215	transferase activity, transferring glycosyl groups
CLD04_17860	COG0438	transferase activity, transferring glycosyl groups
CLD04_17865	COG1086	Polysaccharide biosynthesis protein
CLD04_17870	COG0489	protein tyrosine kinase activity
CLD04_17875	COG3944	biosynthesis protein
CLD04_17880	COG1396	sequence-specific DNA binding
CLD04_17885	COG2272	Belongs to the type-B carboxylesterase lipase family
CLD04_17895	COG3479	Phenolic acid decarboxylase
CLD04_17905	COG1794	racemase activity, acting on amino acids and derivatives
CLD04_17910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLD04_17915	COG1621	beta-fructofuranosidase activity
CLD04_17920	COG1621	beta-fructofuranosidase activity
CLD04_17925	COG0531	amino acid
CLD04_17930	COG1309	transcriptional regulator
CLD04_17935	COG2076	Multidrug Resistance protein
CLD04_17940	COG2076	Multidrug Resistance protein
CLD04_17955	COG0740	serine-type endopeptidase activity
CLD04_17960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLD04_17965	COG0366	Alpha amylase catalytic
CLD04_17970	COG1554	hydrolase, family 65, central catalytic
CLD04_17975	COG5521	maltodextrose utilization protein MalA
CLD04_17980	COG3833	ABC-type maltose transport systems, permease component
CLD04_17985	COG1175	transmembrane transport
CLD04_17990	COG2182	Extracellular solute-binding protein
CLD04_17995	COG0366	Alpha amylase catalytic
CLD04_18000	COG1609	Transcriptional regulator
CLD04_18005	COG1611	Belongs to the LOG family
CLD04_18010	COG1694	Mazg nucleotide pyrophosphohydrolase
CLD04_18015	COG0659	secondary active sulfate transmembrane transporter activity
CLD04_18020	COG0288	reversible hydration of carbon dioxide
CLD04_18025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLD04_18030	COG0577	efflux transmembrane transporter activity
CLD04_18035	COG1136	(ABC) transporter
CLD04_18040	COG5002	protein histidine kinase activity
CLD04_18045	COG0745	RESPONSE REGULATOR receiver
CLD04_18055	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CLD04_18060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLD04_18065	COG1481	regulation of sporulation
CLD04_18070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CLD04_18075	COG1660	Displays ATPase and GTPase activities
CLD04_18080	COG1051	belongs to the nudix hydrolase family
CLD04_18085	COG0492	ferredoxin-NADP+ reductase activity
CLD04_18090	COG3883	PFAM NLP P60 protein
CLD04_18090	COG0791	NLP P60 protein
CLD04_18095	COG0457	Tetratricopeptide repeat
CLD04_18100	COG1132	(ABC) transporter
CLD04_18120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLD04_18120	COG0140	phosphoribosyl-ATP diphosphatase activity
CLD04_18125	COG0107	imidazoleglycerol-phosphate synthase activity
CLD04_18130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLD04_18135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLD04_18140	COG0131	Imidazoleglycerol-phosphate dehydratase
CLD04_18145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLD04_18150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLD04_18155	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CLD04_18160	COG4990	cell redox homeostasis
CLD04_18165	COG5297	Belongs to the glycosyl hydrolase family 6
CLD04_18170	COG0110	maltose O-acetyltransferase activity
CLD04_18175	COG0546	phosphoglycolate phosphatase activity
CLD04_18180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLD04_18185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLD04_18190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLD04_18195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLD04_18200	COG0363	glucosamine-6-phosphate deaminase activity
CLD04_18210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CLD04_18215	COG1950	PFAM Membrane protein of
CLD04_18220	COG1983	PspC domain protein
CLD04_18225	COG3595	metallopeptidase activity
CLD04_18240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLD04_18245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLD04_18250	COG0556	nucleotide-excision repair
CLD04_18255	COG4897	Protein conserved in bacteria
CLD04_18260	COG3848	Pyruvate phosphate dikinase
CLD04_18260	COG0574	Belongs to the PEP-utilizing enzyme family
CLD04_18265	COG1309	transcriptional regulator
CLD04_18270	COG2814	Major facilitator Superfamily
CLD04_18275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLD04_18285	COG3409	Peptidoglycan-binding domain 1 protein
CLD04_18285	COG0793	Belongs to the peptidase S41A family
CLD04_18290	COG2177	Part of the ABC transporter FtsEX involved in
CLD04_18295	COG2884	Cell division ATP-binding protein ftsE
CLD04_18300	COG2010	Cytochrome c
CLD04_18305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLD04_18315	COG0653	protein targeting
CLD04_18325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CLD04_18340	COG1516	flagellar protein fliS
CLD04_18345	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLD04_18350	COG1334	flagellar protein FlaG
CLD04_18360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLD04_18365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLD04_18370	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLD04_18380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLD04_18385	COG4786	Flagellar basal body rod
CLD04_18385	COG1256	bacterial-type flagellum assembly
CLD04_18390	COG3418	PFAM FlgN family protein
CLD04_18395	COG2747	anti-sigma28 factor FlgM
CLD04_18405	COG1040	competence protein
CLD04_18415	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CLD04_18420	COG1307	EDD domain protein, DegV family
CLD04_18425	COG2197	response regulator
CLD04_18430	COG4585	Histidine kinase
CLD04_18435	COG1739	Uncharacterized protein family UPF0029
CLD04_18440	COG1316	TRANSCRIPTIONal
CLD04_18445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLD04_18450	COG0438	transferase activity, transferring glycosyl groups
CLD04_18455	COG1215	transferase activity, transferring glycosyl groups
CLD04_18460	COG3206	protein involved in exopolysaccharide biosynthesis
CLD04_18465	COG3307	-O-antigen
CLD04_18470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CLD04_18475	COG0297	glycogen (starch) synthase activity
CLD04_18475	COG0438	transferase activity, transferring glycosyl groups
CLD04_18480	COG2244	polysaccharide biosynthetic process
CLD04_18495	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLD04_18495	COG2247	cell wall binding repeat
CLD04_18500	COG2385	sporulation resulting in formation of a cellular spore
CLD04_18500	COG2247	cell wall binding repeat
CLD04_18510	COG1316	TRANSCRIPTIONal
CLD04_18515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLD04_18535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLD04_18540	COG1134	teichoic acid transport
CLD04_18545	COG1682	transport, permease protein
CLD04_18560	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CLD04_18560	COG1215	transferase activity, transferring glycosyl groups
CLD04_18610	COG4193	domain, Protein
CLD04_18615	COG1482	cell wall glycoprotein biosynthetic process
CLD04_18620	COG0697	spore germination
CLD04_18625	COG0814	amino acid
CLD04_18635	COG2814	Major facilitator Superfamily
CLD04_18640	COG1316	TRANSCRIPTIONal
CLD04_18645	COG0561	phosphatase activity
CLD04_18655	COG0791	NLP P60 protein
CLD04_18665	COG2843	Capsule synthesis protein
CLD04_18675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLD04_18680	COG1609	Transcriptional regulator
CLD04_18685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLD04_18690	COG1869	D-ribose catabolic process
CLD04_18695	COG1129	ABC transporter
CLD04_18700	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLD04_18705	COG1879	ABC-type sugar transport system periplasmic component
CLD04_18710	COG3103	Sh3 type 3 domain protein
CLD04_18720	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLD04_18725	COG3527	Alpha-acetolactate decarboxylase
CLD04_18730	COG0028	Belongs to the TPP enzyme family
CLD04_18735	COG0583	DNA-binding transcription factor activity
CLD04_18755	COG5337	Spore coat protein CotH
CLD04_18765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLD04_18775	COG0405	Gamma-glutamyltransferase
CLD04_18780	COG1522	sequence-specific DNA binding
CLD04_18785	COG2059	Chromate
CLD04_18790	COG2059	Chromate
CLD04_18820	COG5444	nuclease activity
CLD04_18845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CLD04_18850	COG4464	protein tyrosine phosphatase activity
CLD04_18855	COG0489	protein tyrosine kinase activity
CLD04_18860	COG3944	biosynthesis protein
CLD04_18870	COG4715	Zinc finger, swim domain protein
CLD04_18875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLD04_18885	COG0561	phosphatase activity
CLD04_18890	COG1349	DNA-binding transcription factor activity
CLD04_18895	COG0629	single-stranded DNA binding
CLD04_18910	COG3764	Sortase (surface protein transpeptidase)
CLD04_18915	COG2972	Histidine kinase
CLD04_18915	COG0745	RESPONSE REGULATOR receiver
CLD04_18920	COG1970	mechanosensitive ion channel activity
CLD04_18925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLD04_18930	COG0457	Tetratricopeptide repeat
CLD04_18935	COG4786	Flagellar basal body rod
CLD04_18940	COG4786	Flagellar basal body rod
CLD04_18945	COG1077	Cell shape determining protein MreB Mrl
CLD04_18950	COG1609	Transcriptional regulator
CLD04_18960	COG1846	Transcriptional regulator
CLD04_18965	COG2814	Major facilitator Superfamily
CLD04_18970	COG3420	alginic acid biosynthetic process
CLD04_18975	COG1953	Uracil, thiamine, allantoin
CLD04_18980	COG0477	Major facilitator Superfamily
CLD04_18985	COG1335	isochorismatase
CLD04_18995	COG0004	ammonium transporteR
CLD04_19000	COG0347	Belongs to the P(II) protein family
CLD04_19005	COG0671	phosphoesterase, PA-phosphatase related
CLD04_19015	COG0739	heme binding
CLD04_19020	COG1247	-acetyltransferase
CLD04_19035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLD04_19040	COG0789	Transcriptional regulator
CLD04_19050	COG2910	NAD(P)H-binding
CLD04_19055	COG1959	2 iron, 2 sulfur cluster binding
CLD04_19060	COG0804	urea catabolic process
CLD04_19065	COG0832	Belongs to the urease beta subunit family
CLD04_19070	COG0831	urea catabolic process
CLD04_19080	COG0411	ABC transporter
CLD04_19090	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLD04_19100	COG3237	CsbD-like
CLD04_19105	COG1994	Peptidase M50
CLD04_19110	COG0457	Tetratricopeptide repeat
CLD04_19120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLD04_19125	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CLD04_19135	COG2304	oxidoreductase activity
CLD04_19145	COG2304	oxidoreductase activity
CLD04_19150	COG2385	sporulation resulting in formation of a cellular spore
CLD04_19155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLD04_19165	COG4836	Membrane
CLD04_19175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLD04_19180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLD04_19185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLD04_19190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLD04_19195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLD04_19200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLD04_19205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLD04_19210	COG0356	it plays a direct role in the translocation of protons across the membrane
CLD04_19220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLD04_19225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLD04_19230	COG4475	Protein of unknown function (DUF436)
CLD04_19235	COG0698	ribose 5-phosphate isomerase
CLD04_19240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLD04_19245	COG1971	Probably functions as a manganese efflux pump
CLD04_19250	COG0009	L-threonylcarbamoyladenylate synthase
CLD04_19255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CLD04_19275	COG2890	protein-(glutamine-N5) methyltransferase activity
CLD04_19280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLD04_19285	COG0346	lactoylglutathione lyase activity
CLD04_19290	COG0789	Transcriptional regulator
CLD04_19295	COG0679	Auxin Efflux Carrier
CLD04_19300	COG0281	malic enzyme
CLD04_19305	COG1435	thymidine kinase activity
CLD04_19310	COG0254	rRNA binding
CLD04_19315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLD04_19320	COG1494	fructose-1,6-bisphosphatase
CLD04_19325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLD04_19330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLD04_19335	COG0191	fructose-bisphosphate aldolase activity
CLD04_19340	COG2204	response regulator
CLD04_19345	COG4821	SIS domain
CLD04_19350	COG2801	Transposase and inactivated derivatives
CLD04_19355	COG2801	Transposase and inactivated derivatives
CLD04_19360	COG0504	CTP synthase activity
CLD04_19365	COG3343	RNA polymerase activity
CLD04_19370	COG1960	acyl-CoA dehydrogenase activity
CLD04_19375	COG2181	nitrate reductase activity
CLD04_19375	COG0247	lactate metabolic process
CLD04_19380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLD04_19385	COG4294	response to UV
CLD04_19395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLD04_19400	COG1132	(ABC) transporter
CLD04_19405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLD04_19420	COG2181	nitrate reductase activity
CLD04_19425	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CLD04_19430	COG1140	nitrate reductase beta subunit
CLD04_19435	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CLD04_19440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLD04_19450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLD04_19455	COG2223	nitrite transmembrane transporter activity
CLD04_19460	COG0018	arginyl-trna synthetase
CLD04_19465	COG4506	Protein conserved in bacteria
CLD04_19480	COG0535	radical SAM domain protein
CLD04_19490	COG1131	(ABC) transporter
CLD04_19495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLD04_19500	COG0612	Peptidase, M16
CLD04_19505	COG0612	Peptidase, M16
CLD04_19515	COG3391	amine dehydrogenase activity
CLD04_19520	COG3391	amine dehydrogenase activity
CLD04_19530	COG0457	Tetratricopeptide repeat
CLD04_19545	COG0010	Belongs to the arginase family
CLD04_19550	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLD04_19555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLD04_19570	COG1994	Peptidase M50
CLD04_19575	COG1942	4-Oxalocrotonate Tautomerase
CLD04_19580	COG1846	Transcriptional regulator
CLD04_19585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLD04_19590	COG0477	Major facilitator Superfamily
CLD04_19595	COG1959	2 iron, 2 sulfur cluster binding
CLD04_19600	COG3465	dGTPase activity
CLD04_19605	COG1078	dGTPase activity
CLD04_19610	COG4844	belongs to the
CLD04_19620	COG0697	spore germination
CLD04_19625	COG0095	Lipoate-protein ligase
CLD04_19630	COG0583	DNA-binding transcription factor activity
CLD04_19635	COG0280	phosphate acetyltransferase
CLD04_19650	COG0436	Aminotransferase
CLD04_19655	COG2814	Major facilitator Superfamily
CLD04_19660	COG0151	Belongs to the GarS family
CLD04_19665	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_19675	COG0077	Prephenate dehydratase
CLD04_19680	COG2814	Major facilitator Superfamily
CLD04_19685	COG0833	amino acid
CLD04_19690	COG4187	Peptidase family M20/M25/M40
CLD04_19695	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_19700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLD04_19710	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CLD04_19715	COG1091	dTDP-4-dehydrorhamnose reductase activity
CLD04_19720	COG1088	dTDP-glucose 4,6-dehydratase activity
CLD04_19725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLD04_19730	COG3980	spore coat polysaccharide biosynthesis protein
CLD04_19735	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CLD04_19740	COG2089	acid synthase
CLD04_19745	COG0456	acetyltransferase
CLD04_19750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLD04_19755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CLD04_19760	COG0463	Glycosyl transferase, family 2
CLD04_19775	COG2363	Small membrane protein
CLD04_19780	COG2233	PERMEase
CLD04_19790	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_19795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLD04_19800	COG1216	Glycosyl transferase, family 2
CLD04_19815	COG1695	Transcriptional regulator
CLD04_19820	COG0351	phosphomethylpyrimidine kinase
CLD04_19830	COG1621	beta-fructofuranosidase activity
CLD04_19835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_19835	COG1263	PTS System
CLD04_19840	COG2116	formate transmembrane transporter activity
CLD04_19845	COG3711	transcriptional antiterminator
CLD04_19855	COG1404	Belongs to the peptidase S8 family
CLD04_19860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLD04_19865	COG0778	Nitroreductase
CLD04_19870	COG0772	Belongs to the SEDS family
CLD04_19880	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CLD04_19885	COG1845	cytochrome c oxidase, subunit III
CLD04_19890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CLD04_19895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CLD04_19900	COG2261	transglycosylase associated protein
CLD04_19905	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CLD04_19910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CLD04_19915	COG2246	polysaccharide biosynthetic process
CLD04_19920	COG1309	transcriptional regulator
CLD04_19930	COG3162	membrane
CLD04_19935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLD04_19940	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CLD04_19945	COG2837	iron assimilation
CLD04_19950	COG2822	iron ion transport
CLD04_19955	COG0672	)-iron permease
CLD04_19965	COG0352	thiamine-phosphate diphosphorylase activity
CLD04_19970	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLD04_19975	COG0583	DNA-binding transcription factor activity
CLD04_19980	COG1380	Effector of murein hydrolase LrgA
CLD04_19985	COG1346	cytolysis
CLD04_19990	COG2814	Major facilitator Superfamily
CLD04_19995	COG4895	conserved protein (DUF2196)
CLD04_20000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLD04_20005	COG0346	lactoylglutathione lyase activity
CLD04_20010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLD04_20015	COG1404	Belongs to the peptidase S8 family
CLD04_20020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_20020	COG1263	PTS System
CLD04_20025	COG3711	transcriptional antiterminator
CLD04_20030	COG1442	glycosyl transferase family 8
CLD04_20035	COG5522	Integral membrane protein (intg_mem_TP0381)
CLD04_20040	COG1846	Transcriptional regulator
CLD04_20050	COG2234	aminopeptidase activity
CLD04_20065	COG2814	Major facilitator Superfamily
CLD04_20070	COG2357	RelA SpoT domain protein
CLD04_20080	COG2801	Transposase and inactivated derivatives
CLD04_20085	COG1575	Belongs to the MenA family. Type 1 subfamily
CLD04_20100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLD04_20105	COG1696	Membrane protein involved in D-alanine export
CLD04_20110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLD04_20115	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CLD04_20120	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CLD04_20125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLD04_20130	COG1486	melibiose metabolic process
CLD04_20135	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLD04_20140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLD04_20145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLD04_20150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLD04_20150	COG3711	transcriptional antiterminator
CLD04_20160	COG2094	Belongs to the DNA glycosylase MPG family
CLD04_20165	COG0753	catalase activity
CLD04_20170	COG2814	Major facilitator Superfamily
CLD04_20180	COG1131	(ABC) transporter
CLD04_20200	COG1595	DNA-templated transcription, initiation
CLD04_20205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CLD04_20210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLD04_20215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CLD04_20220	COG4988	ABC transporter
CLD04_20225	COG1294	oxidase, subunit
CLD04_20230	COG1271	oxidase subunit
CLD04_20235	COG3493	citrate carrier protein
CLD04_20240	COG0501	Belongs to the peptidase M48B family
CLD04_20250	COG0726	polysaccharide deacetylase
CLD04_20255	COG3842	ATPase activity
CLD04_20260	COG2508	Transcriptional regulator
CLD04_20265	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_20270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLD04_20280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLD04_20290	COG4585	Histidine kinase
CLD04_20295	COG2197	response regulator
CLD04_20300	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLD04_20310	COG4894	glucomannan catabolic process
CLD04_20315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLD04_20320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLD04_20330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CLD04_20335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CLD04_20340	COG2610	gluconate transmembrane transporter activity
CLD04_20345	COG0500	methyltransferase
CLD04_20355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLD04_20365	COG2323	membrane
CLD04_20380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLD04_20440	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLD04_20460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLD04_20475	COG0753	catalase activity
CLD04_20475	COG0693	protein deglycase activity
CLD04_20480	COG2851	Citrate transporter
CLD04_20505	COG2270	Major facilitator Superfamily
CLD04_20510	COG0513	Belongs to the DEAD box helicase family
CLD04_20515	COG3401	FG-GAP repeat protein
CLD04_20515	COG2755	lipolytic protein G-D-S-L family
CLD04_20570	COG3209	COG3209 Rhs family protein
CLD04_20575	COG0697	spore germination
CLD04_20580	COG0589	response to stress
CLD04_20585	COG2723	6-phospho-beta-galactosidase activity
CLD04_20590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLD04_20590	COG1263	PTS System
CLD04_20590	COG2190	(PTS) system
CLD04_20600	COG5444	nuclease activity
CLD04_20630	COG3507	Belongs to the glycosyl hydrolase 43 family
CLD04_20640	COG1228	amidohydrolase
CLD04_20645	COG0010	Belongs to the arginase family
CLD04_20650	COG0833	amino acid
CLD04_20655	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CLD04_20660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLD04_20665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLD04_20670	COG2390	Transcriptional regulator
CLD04_20680	COG3192	ethanolamine utilization protein
CLD04_20685	COG2079	MmgE PrpD family protein
CLD04_20695	COG1126	abc transporter atp-binding protein
CLD04_20700	COG0765	amino acid transport
CLD04_20705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLD04_20720	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CLD04_20725	COG0561	phosphatase activity
CLD04_20755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLD04_20760	COG5294	Protein conserved in bacteria
CLD04_20765	COG0577	efflux transmembrane transporter activity
CLD04_20770	COG1136	(ABC) transporter
CLD04_20775	COG2205	protein histidine kinase activity
CLD04_20780	COG0745	RESPONSE REGULATOR receiver
CLD04_20785	COG0191	fructose-bisphosphate aldolase activity
CLD04_20790	COG1082	Xylose isomerase domain protein TIM barrel
CLD04_20795	COG1082	Xylose isomerase domain protein TIM barrel
CLD04_20800	COG0673	inositol 2-dehydrogenase activity
CLD04_20805	COG2814	Major facilitator Superfamily
CLD04_20810	COG1082	Xylose isomerase domain protein TIM barrel
CLD04_20815	COG3962	Belongs to the TPP enzyme family
CLD04_20820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLD04_20830	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_20835	COG1349	DNA-binding transcription factor activity
CLD04_20840	COG0667	Aldo Keto reductase
CLD04_20855	COG2814	Major facilitator Superfamily
CLD04_20860	COG0326	Molecular chaperone. Has ATPase activity
CLD04_20875	COG1309	transcriptional regulator
CLD04_20880	COG1012	belongs to the aldehyde dehydrogenase family
CLD04_20885	COG1714	RDD family
CLD04_20890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLD04_20900	COG1714	RDD family
CLD04_20910	COG1917	Cupin 2, conserved barrel domain protein
CLD04_20915	COG1309	transcriptional regulator
CLD04_20920	COG1028	Short-chain dehydrogenase reductase Sdr
CLD04_20925	COG1846	Transcriptional regulator
CLD04_20930	COG1380	Effector of murein hydrolase LrgA
CLD04_20935	COG1346	cytolysis
CLD04_20945	COG5039	Polysaccharide pyruvyl transferase
CLD04_20950	COG1929	Belongs to the glycerate kinase type-1 family
CLD04_20955	COG1802	Transcriptional regulator
CLD04_20960	COG1070	Carbohydrate kinase
CLD04_20965	COG2610	gluconate transmembrane transporter activity
CLD04_20970	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CLD04_20975	COG0450	alkyl hydroperoxide reductase
CLD04_20980	COG3634	alkyl hydroperoxide reductase activity
CLD04_20985	COG2723	6-phospho-beta-galactosidase activity
CLD04_21000	COG2188	Transcriptional regulator
CLD04_21015	COG1131	(ABC) transporter
CLD04_21020	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CLD04_21035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLD04_21050	COG1063	alcohol dehydrogenase
CLD04_21070	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CLD04_21075	COG0456	acetyltransferase
CLD04_21080	COG0457	Tetratricopeptide repeat
CLD04_21090	COG0010	Belongs to the arginase family
CLD04_21095	COG0833	amino acid
CLD04_21100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLD04_21105	COG3829	transcription factor binding
CLD04_21110	COG5002	protein histidine kinase activity
CLD04_21130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLD04_21135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLD04_21140	COG4853	Protein conserved in bacteria
CLD04_21145	COG4863	YycH protein
CLD04_21150	COG5002	protein histidine kinase activity
CLD04_21155	COG0745	RESPONSE REGULATOR receiver
CLD04_21185	COG0346	lactoylglutathione lyase activity
CLD04_21190	COG0305	Participates in initiation and elongation during chromosome replication
CLD04_21205	COG3093	addiction module antidote protein HigA
CLD04_21210	COG2807	transmembrane transport
CLD04_21215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLD04_21220	COG0359	binds to the 23S rRNA
CLD04_21225	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLD04_21230	COG4241	membrane
CLD04_21240	COG5577	PFAM Coat F domain
CLD04_21245	COG1733	regulation of RNA biosynthetic process
CLD04_21250	COG1227	inorganic diphosphatase activity
CLD04_21265	COG2271	Major facilitator Superfamily
CLD04_21285	COG4319	ketosteroid isomerase
CLD04_21290	COG1357	PFAM Pentapeptide repeats (8 copies)
CLD04_21295	COG2814	Major facilitator Superfamily
CLD04_21300	COG0583	DNA-binding transcription factor activity
CLD04_21305	COG2153	protein acetylation
CLD04_21315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLD04_21320	COG1846	Transcriptional regulator
CLD04_21325	COG2153	protein acetylation
CLD04_21330	COG2364	Membrane
CLD04_21335	COG0456	acetyltransferase
CLD04_21340	COG2315	Protein conserved in bacteria
CLD04_21345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLD04_21355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLD04_21360	COG0798	PFAM Bile acid sodium symporter
CLD04_21365	COG0346	lactoylglutathione lyase activity
CLD04_21370	COG0640	Transcriptional regulator
CLD04_21390	COG1331	Highly conserved protein containing a thioredoxin domain
CLD04_21395	COG1266	CAAX protease self-immunity
CLD04_21400	COG2814	Major facilitator Superfamily
CLD04_21400	COG0477	Major facilitator Superfamily
CLD04_21405	COG0110	maltose O-acetyltransferase activity
CLD04_21410	COG0346	lactoylglutathione lyase activity
CLD04_21415	COG1609	Transcriptional regulator
CLD04_21420	COG0708	Exodeoxyribonuclease III
CLD04_21425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLD04_21430	COG0629	single-stranded DNA binding
CLD04_21435	COG0360	Binds together with S18 to 16S ribosomal RNA
CLD04_21440	COG0012	GTP binding
CLD04_21445	COG0243	molybdopterin cofactor binding
CLD04_21450	COG4481	Protein conserved in bacteria
CLD04_21455	COG3949	Membrane
CLD04_21465	COG1475	DNA binding
CLD04_21470	COG1192	Involved in chromosome partitioning
CLD04_21480	COG1475	DNA binding
CLD04_21485	COG0357	Ribosomal RNA small subunit methyltransferase G
CLD04_21490	COG0445	tRNA wobble uridine modification
CLD04_21495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLD04_21500	COG1847	R3H domain protein
CLD04_21505	COG0706	membrane insertase activity
CLD04_21510	COG0594	ribonuclease P activity
CLD04_21515	COG0230	Belongs to the bacterial ribosomal protein bL34 family