locus-tag	class	description
M036_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M036_00010	COG0592	DNA-directed DNA polymerase activity
M036_00015	COG2501	S4 domain
M036_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M036_00030	COG0187	DNA topoisomerase II activity
M036_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M036_00070	COG0516	GMP reductase activity
M036_00070	COG0517	IMP dehydrogenase activity
M036_00075	COG1686	Belongs to the peptidase S11 family
M036_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M036_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M036_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M036_00100	COG1428	Deoxynucleoside kinase
M036_00105	COG1428	Deoxynucleoside kinase
M036_00110	COG3858	chitin binding
M036_00110	COG1388	LysM domain
M036_00115	COG1335	isochorismatase
M036_00120	COG0590	tRNA wobble adenosine to inosine editing
M036_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M036_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M036_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M036_00170	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M036_00175	COG3853	Toxic anion resistance protein (TelA)
M036_00180	COG1982	Orn Lys Arg decarboxylase major
M036_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M036_00190	COG3870	Protein conserved in bacteria
M036_00195	COG1728	Protein conserved in bacteria
M036_00200	COG0470	DNA polymerase III
M036_00205	COG1774	PSP1 C-terminal conserved region
M036_00210	COG4467	Involved in initiation control of chromosome replication
M036_00215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M036_00220	COG2827	Endonuclease containing a URI domain
M036_00225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M036_00230	COG2002	toxin-antitoxin pair type II binding
M036_00235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M036_00235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M036_00240	COG0084	hydrolase, TatD family'
M036_00245	COG3583	domain protein
M036_00245	COG3584	3D domain protein
M036_00250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M036_00255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M036_00265	COG4466	Protein conserved in bacteria
M036_00275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M036_00280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M036_00285	COG0251	oxidation-reduction process
M036_00290	COG2088	sporulation resulting in formation of a cellular spore
M036_00300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M036_00305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M036_00310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M036_00315	COG0193	aminoacyl-tRNA hydrolase activity
M036_00325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M036_00330	COG2002	toxin-antitoxin pair type II binding
M036_00335	COG2244	polysaccharide biosynthetic process
M036_00340	COG3956	TIGRFAM MazG family protein
M036_00345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M036_00360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M036_00365	COG1098	S1 RNA binding domain
M036_00380	COG2208	phosphoserine phosphatase activity
M036_00385	COG2304	oxidoreductase activity
M036_00390	COG0515	serine threonine protein kinase
M036_00395	COG0037	tRNA processing
M036_00405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M036_00410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M036_00415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M036_00420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M036_00425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M036_00430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M036_00435	COG0512	Glutamine amidotransferase of anthranilate synthase
M036_00440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M036_00445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M036_00450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M036_00455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M036_00460	COG1396	sequence-specific DNA binding
M036_00465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M036_00470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M036_00490	COG4463	regulation of RNA biosynthetic process
M036_00495	COG3880	PFAM UvrB UvrC protein
M036_00500	COG3869	Catalyzes the specific phosphorylation of arginine residues in
M036_00505	COG0542	response to heat
M036_00510	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M036_00515	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M036_00520	COG4956	integral membrane protein (PIN domain superfamily)
M036_00525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M036_00530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M036_00535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M036_00545	COG1045	serine acetyltransferase
M036_00550	COG0215	cysteine-tRNA ligase activity
M036_00555	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M036_00560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M036_00565	COG3688	RNA-binding protein containing a PIN domain
M036_00570	COG1595	DNA-templated transcription, initiation
M036_00575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M036_00580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M036_00585	COG0250	Participates in transcription elongation, termination and antitermination
M036_00590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M036_00595	COG0081	regulation of translation
M036_00600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M036_00605	COG0222	ribosome binding
M036_00610	COG2813	Specifically methylates the guanine in position
M036_00615	COG0085	RNA polymerase activity
M036_00620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M036_00625	COG1358	cellular component organization or biogenesis
M036_00630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M036_00635	COG0049	tRNA binding
M036_00640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M036_00645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M036_00650	COG0596	Alpha beta hydrolase
M036_00655	COG0051	transcription antitermination factor activity, RNA binding
M036_00660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M036_00665	COG0088	Forms part of the polypeptide exit tunnel
M036_00670	COG0089	rRNA binding
M036_00675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M036_00680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M036_00685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M036_00690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M036_00695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M036_00700	COG0255	Belongs to the universal ribosomal protein uL29 family
M036_00705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M036_00710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M036_00720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M036_00730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M036_00735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M036_00740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M036_00750	COG1841	ribosomal large subunit assembly
M036_00755	COG0200	Binds to the 23S rRNA
M036_00760	COG0201	protein transport
M036_00765	COG0563	adenylate kinase activity
M036_00770	COG0024	Methionine aminopeptidase
M036_00775	COG2163	COG2163 Ribosomal protein L14E L6E L27E
M036_00780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M036_00785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M036_00790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M036_00795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M036_00800	COG0202	RNA polymerase activity
M036_00805	COG0203	ribosomal protein L17
M036_00810	COG1122	ATPase activity
M036_00815	COG1122	ATPase activity
M036_00820	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M036_00825	COG0101	tRNA pseudouridine synthase activity
M036_00830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M036_00835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M036_00840	COG2226	methyltransferase
M036_00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
M036_00860	COG0489	protein tyrosine kinase activity
M036_00870	COG2194	sulfuric ester hydrolase activity
M036_00875	COG0726	polysaccharide deacetylase
M036_00905	COG0659	secondary active sulfate transmembrane transporter activity
M036_00910	COG0385	Bile acid
M036_00915	COG2819	hydrolase of the alpha beta superfamily
M036_00920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_00925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_00930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M036_00935	COG2207	Transcriptional regulator
M036_00935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M036_00940	COG3876	Protein conserved in bacteria
M036_00945	COG1472	Belongs to the glycosyl hydrolase 3 family
M036_00950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M036_00955	COG1263	PTS System
M036_00955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_00960	COG1737	Transcriptional regulator
M036_00965	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M036_00970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M036_00975	COG1683	Conserved Protein
M036_01005	COG1595	DNA-templated transcription, initiation
M036_01010	COG5662	AntiSigma factor
M036_01015	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M036_01020	COG4856	YbbR-like protein
M036_01025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M036_01030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M036_01035	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M036_01040	COG2169	Transcriptional regulator
M036_01045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M036_01050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M036_01055	COG3002	Belongs to the UPF0753 family
M036_01060	COG0288	reversible hydration of carbon dioxide
M036_01070	COG5609	conserved protein (DUF2294)
M036_01075	COG0640	Transcriptional regulator
M036_01080	COG2814	Major facilitator Superfamily
M036_01090	COG0535	radical SAM domain protein
M036_01095	COG1266	CAAX protease self-immunity
M036_01100	COG1131	(ABC) transporter
M036_01110	COG1413	lyase activity
M036_01115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_01120	COG0596	Alpha beta hydrolase
M036_01130	COG0642	Histidine kinase
M036_01140	COG0515	serine threonine protein kinase
M036_01155	COG1113	amino acid transport
M036_01170	COG2602	Beta-lactamase
M036_01175	COG2124	cytochrome p450
M036_01185	COG0531	amino acid
M036_01190	COG0584	glycerophosphoryl diester phosphodiesterase
M036_01195	COG2271	Major facilitator Superfamily
M036_01205	COG0456	acetyltransferase
M036_01205	COG1846	Transcriptional regulator
M036_01210	COG2271	Major facilitator Superfamily
M036_01225	COG3409	Peptidoglycan-binding domain 1 protein
M036_01230	COG0697	spore germination
M036_01235	COG2207	Transcriptional regulator
M036_01235	COG1917	Cupin 2, conserved barrel domain protein
M036_01240	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M036_01245	COG3591	Belongs to the peptidase S1B family
M036_01255	COG0596	Alpha beta hydrolase
M036_01260	COG1183	phosphatidylcholine synthase activity
M036_01265	COG0586	Pfam SNARE associated Golgi protein
M036_01270	COG0688	phosphatidylethanolamine metabolic process
M036_01280	COG2312	Erythromycin esterase
M036_01285	COG2207	Transcriptional regulator
M036_01295	COG1301	dicarboxylic acid transport
M036_01300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_01300	COG1263	PTS System
M036_01300	COG2190	(PTS) system
M036_01305	COG0363	glucosamine-6-phosphate deaminase activity
M036_01320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M036_01325	COG0833	amino acid
M036_01330	COG2040	homocysteine
M036_01340	COG1115	amino acid carrier protein
M036_01345	COG2066	Belongs to the glutaminase family
M036_01350	COG4191	Histidine kinase
M036_01355	COG0784	Response regulator, receiver
M036_01360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M036_01365	COG1012	belongs to the aldehyde dehydrogenase family
M036_01370	COG2271	Major facilitator Superfamily
M036_01375	COG4948	Mandelate Racemase Muconate Lactonizing
M036_01380	COG2186	Transcriptional regulator
M036_01385	COG2721	sulfolactate sulfo-lyase activity
M036_01390	COG3173	Aminoglycoside phosphotransferase
M036_01400	COG0697	spore germination
M036_01405	COG0745	RESPONSE REGULATOR receiver
M036_01410	COG2205	protein histidine kinase activity
M036_01415	COG1131	(ABC) transporter
M036_01435	COG3773	Cell wall hydrolase
M036_01440	COG2304	oxidoreductase activity
M036_01450	COG3540	Alkaline phosphatase
M036_01455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M036_01460	COG0805	protein transport
M036_01465	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M036_01470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M036_01475	COG0477	Major facilitator Superfamily
M036_01480	COG1309	transcriptional regulator
M036_01485	COG0252	asparaginase activity
M036_01490	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M036_01495	COG1714	RDD family
M036_01500	COG1405	negative regulation of cell septum assembly
M036_01500	COG3012	SEC-C Motif Domain Protein
M036_01505	COG3290	protein histidine kinase activity
M036_01510	COG3279	Response regulator of the LytR AlgR family
M036_01515	COG4555	ABC transporter
M036_01520	COG1668	transmembrane transport
M036_01525	COG0667	Aldo Keto reductase
M036_01535	COG1595	DNA-templated transcription, initiation
M036_01540	COG1595	DNA-templated transcription, initiation
M036_01545	COG1876	peptidase activity
M036_01550	COG0457	Tetratricopeptide repeat
M036_01555	COG1028	Short-chain dehydrogenase reductase Sdr
M036_01560	COG0366	Alpha amylase catalytic
M036_01565	COG0803	Belongs to the bacterial solute-binding protein 9 family
M036_01570	COG1121	(ABC) transporter
M036_01575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M036_01580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M036_01585	COG2310	stress, protein
M036_01590	COG2310	stress, protein
M036_01595	COG2310	stress, protein
M036_01600	COG0861	Integral membrane protein TerC family
M036_01610	COG3853	Toxic anion resistance protein (TelA)
M036_01615	COG0477	Major facilitator Superfamily
M036_01625	COG0640	Transcriptional regulator
M036_01630	COG4175	Glycine betaine
M036_01630	COG0517	IMP dehydrogenase activity
M036_01635	COG4176	ABC-type proline glycine betaine transport system permease component
M036_01640	COG2113	Glycine betaine
M036_01645	COG1473	amidohydrolase
M036_01650	COG1288	antiporter activity
M036_01660	COG0366	Alpha amylase catalytic
M036_01665	COG0039	L-malate dehydrogenase activity
M036_01670	COG1620	l-lactate permease
M036_01675	COG2814	Major facilitator Superfamily
M036_01680	COG1846	Transcriptional regulator
M036_01685	COG1280	lysine exporter protein (LysE YggA)
M036_01690	COG3403	YqcI/YcgG family
M036_01695	COG1113	amino acid transport
M036_01700	COG3665	Urea carboxylase-associated protein
M036_01705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M036_01710	COG1660	Displays ATPase and GTPase activities
M036_01715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M036_01720	COG2226	methyltransferase
M036_01725	COG0583	DNA-binding transcription factor activity
M036_01730	COG3458	cephalosporin-C deacetylase activity
M036_01735	COG3541	Predicted nucleotidyltransferase
M036_01740	COG0506	proline dehydrogenase activity
M036_01745	COG1012	belongs to the aldehyde dehydrogenase family
M036_01750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M036_01755	COG2508	Transcriptional regulator
M036_01760	COG3689	TIGRFAM TIGR03943 family protein
M036_01765	COG0701	Predicted permease
M036_01770	COG2267	carboxylic ester hydrolase activity
M036_01775	COG0492	ferredoxin-NADP+ reductase activity
M036_01780	COG1587	Uroporphyrinogen-III synthase
M036_01780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M036_01785	COG2146	nitrite reductase [NAD(P)H] activity
M036_01790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M036_01795	COG0243	molybdopterin cofactor binding
M036_01800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M036_01805	COG2223	nitrite transmembrane transporter activity
M036_01810	COG1469	GTP cyclohydrolase I activity
M036_01815	COG1376	ErfK ybiS ycfS ynhG family protein
M036_01820	COG0523	cobalamin synthesis protein
M036_01825	COG0765	amino acid transport
M036_01830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M036_01840	COG1714	RDD family
M036_01850	COG2723	6-phospho-beta-galactosidase activity
M036_01860	COG3209	COG3209 Rhs family protein
M036_01865	COG3290	protein histidine kinase activity
M036_01865	COG0840	transmembrane signaling receptor activity
M036_01870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M036_01875	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M036_01880	COG1733	regulation of RNA biosynthetic process
M036_01890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_01895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_01900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_01905	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M036_01910	COG2814	Major facilitator Superfamily
M036_01920	COG0697	spore germination
M036_01925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M036_01935	COG2364	Membrane
M036_01940	COG1126	abc transporter atp-binding protein
M036_01945	COG0765	amino acid transport
M036_01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M036_01955	COG0583	DNA-binding transcription factor activity
M036_01960	COG0163	prenyltransferase activity
M036_01965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M036_01980	COG0596	Alpha beta hydrolase
M036_01985	COG3104	oligopeptide transport
M036_01990	COG5434	Belongs to the glycosyl hydrolase 28 family
M036_02000	COG0697	spore germination
M036_02010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M036_02015	COG1136	(ABC) transporter
M036_02020	COG0577	efflux transmembrane transporter activity
M036_02025	COG0745	RESPONSE REGULATOR receiver
M036_02030	COG3850	Histidine kinase
M036_02030	COG5002	protein histidine kinase activity
M036_02035	COG0457	Tetratricopeptide repeat
M036_02055	COG0527	aspartate kinase activity
M036_02060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_02065	COG4605	iron ion homeostasis
M036_02070	COG4604	ABC transporter, ATP-binding protein
M036_02075	COG4607	ABC-type enterochelin transport system periplasmic component
M036_02080	COG2814	Major facilitator Superfamily
M036_02085	COG1309	transcriptional regulator
M036_02090	COG0778	Nitroreductase
M036_02095	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M036_02100	COG0640	Transcriptional regulator
M036_02105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M036_02110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M036_02115	COG1012	belongs to the aldehyde dehydrogenase family
M036_02120	COG4975	Glucose uptake
M036_02125	COG1028	Short-chain dehydrogenase reductase Sdr
M036_02130	COG4549	nuclear export factor GLE1
M036_02135	COG2372	response to copper ion
M036_02135	COG1276	copper resistance
M036_02140	COG1349	DNA-binding transcription factor activity
M036_02150	COG2213	PTS system mannitol-specific
M036_02155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M036_02160	COG0246	Mannitol dehydrogenase
M036_02165	COG0473	3-isopropylmalate dehydrogenase activity
M036_02170	COG0681	Belongs to the peptidase S26 family
M036_02175	COG0412	Dienelactone hydrolase
M036_02180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M036_02190	COG0561	phosphatase activity
M036_02195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M036_02200	COG1914	H( )-stimulated, divalent metal cation uptake system
M036_02205	COG4336	lyase activity
M036_02210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M036_02215	COG1984	allophanate hydrolase subunit 2
M036_02220	COG1414	Transcriptional regulator
M036_02225	COG2755	lipolytic protein G-D-S-L family
M036_02235	COG2329	Antibiotic biosynthesis monooxygenase
M036_02240	COG0768	penicillin binding
M036_02245	COG4989	oxidoreductase activity
M036_02250	COG3711	transcriptional antiterminator
M036_02255	COG0318	PFAM AMP-dependent synthetase and ligase
M036_02260	COG2226	methyltransferase
M036_02265	COG1028	Short-chain dehydrogenase reductase Sdr
M036_02270	COG1917	Cupin 2, conserved barrel domain protein
M036_02275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M036_02280	COG3871	stress protein (general stress protein 26)
M036_02290	COG2814	Major facilitator Superfamily
M036_02295	COG1522	sequence-specific DNA binding
M036_02300	COG0551	DNA topoisomerase type I activity
M036_02300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M036_02305	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M036_02310	COG3706	GGDEF domain
M036_02315	COG5298	Protein conserved in bacteria
M036_02320	COG1215	transferase activity, transferring glycosyl groups
M036_02330	COG0531	amino acid
M036_02335	COG0494	nUDIX hydrolase
M036_02340	COG0028	Belongs to the TPP enzyme family
M036_02355	COG1914	H( )-stimulated, divalent metal cation uptake system
M036_02360	COG2261	transglycosylase associated protein
M036_02365	COG4876	unkown
M036_02370	COG2217	Heavy metal translocating P-type atpase
M036_02375	COG3729	General stress protein
M036_02380	COG0662	Cupin 2, conserved barrel domain protein
M036_02385	COG2329	Antibiotic biosynthesis monooxygenase
M036_02390	COG3546	catalase activity
M036_02395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M036_02400	COG3290	protein histidine kinase activity
M036_02405	COG4565	transcriptional regulatory protein
M036_02410	COG1301	dicarboxylic acid transport
M036_02415	COG0628	permease
M036_02425	COG1131	(ABC) transporter
M036_02430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M036_02440	COG1960	acyl-CoA dehydrogenase activity
M036_02455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M036_02460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_02465	COG1181	Belongs to the D-alanine--D-alanine ligase family
M036_02470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M036_02475	COG0513	Belongs to the DEAD box helicase family
M036_02480	COG3402	PFAM membrane-flanked domain
M036_02485	COG3428	Bacterial PH domain
M036_02490	COG0705	Rhomboid family
M036_02495	COG0736	holo-[acyl-carrier-protein] synthase activity
M036_02500	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M036_02505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M036_02510	COG0864	Transcriptional regulator
M036_02515	COG2337	Toxic component of a toxin-antitoxin (TA) module
M036_02520	COG1366	Belongs to the anti-sigma-factor antagonist family
M036_02525	COG1366	Belongs to the anti-sigma-factor antagonist family
M036_02530	COG2172	sigma factor antagonist activity
M036_02535	COG2208	phosphoserine phosphatase activity
M036_02540	COG1366	Belongs to the anti-sigma-factor antagonist family
M036_02545	COG2172	sigma factor antagonist activity
M036_02550	COG1191	sigma factor activity
M036_02555	COG2208	phosphoserine phosphatase activity
M036_02570	COG1673	EVE domain
M036_02575	COG1846	Transcriptional regulator
M036_02580	COG2183	response to ionizing radiation
M036_02590	COG3091	SprT-like family
M036_02630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M036_02635	COG1522	sequence-specific DNA binding
M036_02640	COG1522	sequence-specific DNA binding
M036_02645	COG1335	isochorismatase
M036_02650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M036_02655	COG2814	Major facilitator Superfamily
M036_02675	COG0693	protein deglycase activity
M036_02680	COG1278	Cold shock
M036_02685	COG1329	Transcriptional regulator
M036_02690	COG0697	spore germination
M036_02695	COG2207	Transcriptional regulator
M036_02695	COG1917	Cupin 2, conserved barrel domain protein
M036_02700	COG0697	spore germination
M036_02705	COG3708	Transcriptional regulator
M036_02705	COG2207	Transcriptional regulator
M036_02710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M036_02715	COG0477	Major facilitator Superfamily
M036_02725	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
M036_02735	COG0697	spore germination
M036_02740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M036_02745	COG2030	dehydratase
M036_02750	COG3545	Serine hydrolase
M036_02755	COG1733	regulation of RNA biosynthetic process
M036_02760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M036_02765	COG1733	regulation of RNA biosynthetic process
M036_02770	COG2249	NAD(P)H dehydrogenase (quinone) activity
M036_02775	COG2814	Major facilitator Superfamily
M036_02780	COG1309	transcriptional regulator
M036_02785	COG0640	Transcriptional regulator
M036_02790	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M036_02795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M036_02800	COG0697	spore germination
M036_02805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M036_02810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M036_02815	COG0640	Transcriptional regulator
M036_02820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M036_02835	COG4585	Histidine kinase
M036_02840	COG2197	response regulator
M036_02845	COG2409	Drug exporters of the RND superfamily
M036_02850	COG0596	Alpha beta hydrolase
M036_02855	COG1811	Na channel or pump
M036_02860	COG0789	Transcriptional regulator
M036_02860	COG4978	Transcriptional regulator
M036_02865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M036_02870	COG0778	Nitroreductase
M036_02875	COG0346	lactoylglutathione lyase activity
M036_02880	COG2259	Doxx family
M036_02885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_02910	COG2323	membrane
M036_02915	COG2323	membrane
M036_02920	COG0071	Belongs to the small heat shock protein (HSP20) family
M036_02935	COG1309	transcriptional regulator
M036_02955	COG1113	amino acid transport
M036_02960	COG2318	DinB family
M036_02965	COG1846	Transcriptional regulator
M036_02970	COG1033	growth of symbiont in host cell
M036_02970	COG2409	Drug exporters of the RND superfamily
M036_02975	COG0778	Nitroreductase
M036_02980	COG1846	Transcriptional regulator
M036_02985	COG2814	Major facilitator Superfamily
M036_02990	COG0730	response to heat
M036_02995	COG1802	Transcriptional regulator
M036_03000	COG1388	LysM domain
M036_03000	COG3858	chitin binding
M036_03005	COG1819	glycosyl
M036_03015	COG1785	Belongs to the alkaline phosphatase family
M036_03020	COG5646	InterPro IPR014922
M036_03030	COG0454	-acetyltransferase
M036_03035	COG1078	dGTPase activity
M036_03040	COG1388	LysM domain
M036_03045	COG2814	Major facilitator Superfamily
M036_03050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M036_03055	COG1447	Phosphotransferase system cellobiose-specific component IIA
M036_03060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M036_03065	COG2723	6-phospho-beta-galactosidase activity
M036_03070	COG2188	Transcriptional regulator
M036_03075	COG1940	carbohydrate kinase activity
M036_03080	COG1482	cell wall glycoprotein biosynthetic process
M036_03085	COG4124	Belongs to the glycosyl hydrolase 26 family
M036_03130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M036_03135	COG0802	atpase or kinase
M036_03140	COG1214	PFAM Peptidase M22, glycoprotease
M036_03145	COG0456	acetyltransferase
M036_03150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M036_03155	COG0488	(ABC) transporter
M036_03160	COG0315	cyclic pyranopterin monophosphate synthase activity
M036_03165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M036_03170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M036_03175	COG0805	protein transport
M036_03185	COG1266	CAAX protease self-immunity
M036_03190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M036_03195	COG0459	protein refolding
M036_03200	COG3378	Phage plasmid primase P4 family
M036_03215	COG0270	DNA (cytosine-5-)-methyltransferase activity
M036_03220	COG0270	DNA (cytosine-5-)-methyltransferase activity
M036_03230	COG1401	restriction endodeoxyribonuclease activity
M036_03245	COG0457	Tetratricopeptide repeat
M036_03250	COG1063	alcohol dehydrogenase
M036_03255	COG2211	Major facilitator Superfamily
M036_03260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M036_03265	COG1842	Phage shock protein A
M036_03270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M036_03275	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M036_03280	COG4260	virion core protein, lumpy skin disease virus
M036_03290	COG2814	Major facilitator Superfamily
M036_03295	COG1063	alcohol dehydrogenase
M036_03300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M036_03305	COG0823	Involved in the tonB-independent uptake of proteins
M036_03320	COG2267	carboxylic ester hydrolase activity
M036_03330	COG2132	Multicopper oxidase
M036_03335	COG1113	amino acid transport
M036_03340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M036_03345	COG0714	Associated with various cellular activities
M036_03350	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M036_03355	COG1305	Transglutaminase-like
M036_03360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M036_03360	COG0519	Catalyzes the synthesis of GMP from XMP
M036_03365	COG2252	PERMEase
M036_03375	COG3064	Membrane
M036_03385	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M036_03395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M036_03400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M036_03405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M036_03410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M036_03415	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M036_03420	COG0047	phosphoribosylformylglycinamidine synthase activity
M036_03425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M036_03430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M036_03435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M036_03440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M036_03445	COG0138	bifunctional purine biosynthesis protein purh
M036_03450	COG0151	Belongs to the GarS family
M036_03455	COG1522	sequence-specific DNA binding
M036_03460	COG0531	amino acid
M036_03470	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M036_03475	COG1470	cell adhesion involved in biofilm formation
M036_03480	COG4496	protein, YerC YecD
M036_03485	COG0069	glutamate synthase activity
M036_03495	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M036_03500	COG0210	DNA helicase
M036_03505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M036_03510	COG4851	CamS sex pheromone cAM373 precursor
M036_03515	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M036_03520	COG1285	pathogenesis
M036_03525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M036_03530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M036_03535	COG0154	amidase activity
M036_03540	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M036_03545	COG1309	transcriptional regulator
M036_03550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M036_03555	COG1597	lipid kinase activity
M036_03560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M036_03565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M036_03570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M036_03575	COG1002	Type II restriction enzyme, methylase subunits
M036_03580	COG1061	Type III restriction enzyme res subunit
M036_03585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M036_03605	COG5444	nuclease activity
M036_03615	COG3391	amine dehydrogenase activity
M036_03630	COG0457	Tetratricopeptide repeat
M036_03640	COG0217	transcriptional regulatory protein
M036_03650	COG1309	transcriptional regulator
M036_03655	COG3631	Ketosteroid isomerase-related protein
M036_03660	COG0702	epimerase
M036_03680	COG3546	catalase activity
M036_03685	COG0454	-acetyltransferase
M036_03695	COG5578	integral membrane protein
M036_03700	COG2972	Histidine kinase
M036_03705	COG2207	Transcriptional regulator
M036_03705	COG4753	response regulator
M036_03710	COG1653	transport
M036_03715	COG1175	transmembrane transport
M036_03720	COG0395	ABC-type sugar transport system, permease component
M036_03725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M036_03730	COG1846	Transcriptional regulator
M036_03735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M036_03745	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M036_03745	COG2124	cytochrome p450
M036_03750	COG1368	sulfuric ester hydrolase activity
M036_03755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M036_03760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M036_03765	COG1442	glycosyl transferase family 8
M036_03770	COG1216	Glycosyl transferase, family 2
M036_03775	COG1442	glycosyl transferase family 8
M036_03785	COG1011	Hydrolase
M036_03790	COG0531	amino acid
M036_03795	COG1012	belongs to the aldehyde dehydrogenase family
M036_03800	COG0840	transmembrane signaling receptor activity
M036_03805	COG0488	(ABC) transporter
M036_03815	COG0789	Transcriptional regulator
M036_03820	COG2814	Major facilitator Superfamily
M036_03825	COG0488	(ABC) transporter
M036_03835	COG0513	Belongs to the DEAD box helicase family
M036_03840	COG0456	acetyltransferase
M036_03845	COG2130	NADP-dependent
M036_03855	COG2211	Major facilitator Superfamily
M036_03860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M036_03865	COG1120	ATPase activity
M036_03870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_03875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_03880	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M036_03895	COG3866	Pectate lyase
M036_03900	COG0471	metal ion transport
M036_03905	COG3290	protein histidine kinase activity
M036_03910	COG4565	transcriptional regulatory protein
M036_03915	COG3181	Tripartite tricarboxylate transporter family receptor
M036_03925	COG2851	Citrate transporter
M036_03930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M036_03935	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M036_03940	COG1254	Belongs to the acylphosphatase family
M036_03945	COG2258	MOSC domain
M036_03965	COG0024	Methionine aminopeptidase
M036_03970	COG1263	PTS System
M036_03970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_03975	COG1368	sulfuric ester hydrolase activity
M036_03985	COG1115	amino acid carrier protein
M036_03990	COG0531	amino acid
M036_04005	COG0697	spore germination
M036_04010	COG1263	PTS System
M036_04010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_04015	COG0366	Alpha amylase catalytic
M036_04020	COG2188	Transcriptional regulator
M036_04025	COG0778	Nitroreductase
M036_04030	COG0737	Belongs to the 5'-nucleotidase family
M036_04035	COG0693	protein deglycase activity
M036_04040	COG2814	Major facilitator Superfamily
M036_04045	COG4840	Belongs to the UPF0435 family
M036_04050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M036_04055	COG4980	gas vesicle protein
M036_04060	COG1295	ribonuclease BN
M036_04070	COG0477	Major facilitator Superfamily
M036_04080	COG0387	Pfam Sodium calcium exchanger
M036_04090	COG0668	transmembrane transport
M036_04095	COG0535	radical SAM domain protein
M036_04105	COG0726	polysaccharide deacetylase
M036_04110	COG2084	Dehydrogenase
M036_04115	COG0598	Magnesium transport protein CorA
M036_04120	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M036_04125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M036_04135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M036_04140	COG4637	Psort location Cytoplasmic, score
M036_04150	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M036_04155	COG0022	dehydrogenase e1 component
M036_04160	COG0508	dehydrogenase complex catalyzes the overall conversion of
M036_04165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M036_04170	COG3284	Transcriptional regulator
M036_04180	COG1742	UPF0060 membrane protein
M036_04205	COG4842	Belongs to the WXG100 family
M036_04210	COG1486	melibiose metabolic process
M036_04215	COG1737	Transcriptional regulator
M036_04220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_04220	COG1263	PTS System
M036_04225	COG1132	(ABC) transporter
M036_04230	COG1132	(ABC) transporter
M036_04235	COG2259	Doxx family
M036_04240	COG2514	catechol 2,3-dioxygenase activity
M036_04245	COG4977	sequence-specific DNA binding
M036_04245	COG1917	Cupin 2, conserved barrel domain protein
M036_04250	COG2814	Major facilitator Superfamily
M036_04255	COG1082	Xylose isomerase domain protein TIM barrel
M036_04260	COG0673	inositol 2-dehydrogenase activity
M036_04265	COG4585	Histidine kinase
M036_04270	COG2197	response regulator
M036_04275	COG1131	(ABC) transporter
M036_04280	COG1511	domain protein
M036_04280	COG0842	Transport permease protein
M036_04285	COG0842	Transport permease protein
M036_04290	COG1695	Transcriptional regulator
M036_04295	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M036_04300	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
M036_04305	COG1309	transcriptional regulator
M036_04310	COG2814	Major facilitator Superfamily
M036_04315	COG2318	DinB family
M036_04320	COG2814	Major facilitator Superfamily
M036_04325	COG1846	Transcriptional regulator
M036_04330	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M036_04330	COG0392	lysyltransferase activity
M036_04335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M036_04340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_04345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_04350	COG0384	phenazine biosynthesis protein PhzF
M036_04355	COG0778	Nitroreductase
M036_04370	COG1090	epimerase
M036_04375	COG2137	regulation of response to DNA damage stimulus
M036_04390	COG2814	Major facilitator Superfamily
M036_04405	COG3103	Sh3 type 3 domain protein
M036_04410	COG5658	integral membrane protein
M036_04415	COG0596	Alpha beta hydrolase
M036_04420	COG0463	Glycosyl transferase, family 2
M036_04425	COG4485	Bacterial membrane protein, YfhO
M036_04430	COG1988	membrane-bound metal-dependent
M036_04435	COG1194	a g-specific adenine glycosylase
M036_04445	COG1028	Short-chain dehydrogenase reductase Sdr
M036_04460	COG3557	Belongs to the UPF0374 family
M036_04465	COG1132	(ABC) transporter
M036_04470	COG4129	membrane
M036_04475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M036_04480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M036_04485	COG0735	belongs to the Fur family
M036_04605	COG4326	sporulation control protein
M036_04615	COG3340	Belongs to the peptidase S51 family
M036_04620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M036_04625	COG0277	FAD linked oxidase domain protein
M036_04635	COG0753	catalase activity
M036_04640	COG1116	anion transmembrane transporter activity
M036_04645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M036_04650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M036_04655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M036_04665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M036_04675	COG1476	TRANSCRIPTIONal
M036_04685	COG3382	B3 4 domain protein
M036_04690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M036_04700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M036_04705	COG0789	Transcriptional regulator
M036_04710	COG1664	Polymer-forming cytoskeletal
M036_04715	COG1664	Polymer-forming cytoskeletal
M036_04725	COG2766	serine protein kinase
M036_04730	COG2718	Belongs to the UPF0229 family
M036_04740	COG1846	Transcriptional regulator
M036_04745	COG1566	PFAM secretion protein HlyD family protein
M036_04750	COG2814	Major facilitator Superfamily
M036_04755	COG0655	NAD(P)H dehydrogenase (quinone) activity
M036_04770	COG1725	Transcriptional regulator
M036_04775	COG1131	(ABC) transporter
M036_04780	COG1131	(ABC) transporter
M036_04785	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M036_04790	COG1278	Cold shock
M036_04800	COG1464	Belongs to the NlpA lipoprotein family
M036_04805	COG3706	GGDEF domain
M036_04810	COG1823	symporter activity
M036_04830	COG5577	PFAM Coat F domain
M036_04835	COG4085	toxin activity
M036_04835	COG1525	nuclease
M036_04835	COG0737	Belongs to the 5'-nucleotidase family
M036_04840	COG3764	Sortase (surface protein transpeptidase)
M036_04845	COG0564	pseudouridine synthase activity
M036_04855	COG0517	IMP dehydrogenase activity
M036_04860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M036_04865	COG3153	acetyltransferase
M036_04865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M036_04870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M036_04875	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M036_04880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M036_04885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M036_04890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M036_04895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M036_04900	COG4585	Histidine kinase
M036_04900	COG2203	Gaf domain
M036_04905	COG2197	response regulator
M036_04910	COG0431	NADPH-dependent FMN reductase
M036_04925	COG0791	NLP P60 protein
M036_04925	COG1388	LysM domain
M036_04930	COG1959	2 iron, 2 sulfur cluster binding
M036_04935	COG0668	transmembrane transport
M036_04940	COG2719	SpoVR family
M036_04945	COG1785	Belongs to the alkaline phosphatase family
M036_04950	COG0791	NLP P60 protein
M036_04950	COG1388	LysM domain
M036_04955	COG0583	DNA-binding transcription factor activity
M036_04960	COG0372	Belongs to the citrate synthase family
M036_04965	COG1028	Short-chain dehydrogenase reductase Sdr
M036_04970	COG0531	amino acid
M036_04975	COG0733	neurotransmitter:sodium symporter activity
M036_04980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M036_04985	COG0456	acetyltransferase
M036_05000	COG1595	DNA-templated transcription, initiation
M036_05005	COG0667	Aldo Keto reductase
M036_05010	COG0204	Acyl-transferase
M036_05015	COG1253	flavin adenine dinucleotide binding
M036_05020	COG0789	Transcriptional regulator
M036_05025	COG0436	Aminotransferase
M036_05030	COG1253	flavin adenine dinucleotide binding
M036_05035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M036_05040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M036_05045	COG0584	glycerophosphoryl diester phosphodiesterase
M036_05055	COG0668	transmembrane transport
M036_05060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M036_05065	COG0726	polysaccharide deacetylase
M036_05070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M036_05075	COG1757	Na H antiporter
M036_05080	COG0589	response to stress
M036_05095	COG1132	(ABC) transporter
M036_05100	COG1132	(ABC) transporter
M036_05105	COG0702	epimerase
M036_05120	COG0189	ligase activity
M036_05125	COG0189	ligase activity
M036_05130	COG4399	Belongs to the UPF0754 family
M036_05135	COG3679	Belongs to the UPF0342 family
M036_05140	COG4335	DNA alkylation repair
M036_05145	COG0561	phosphatase activity
M036_05150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M036_05155	COG0475	glutathione-regulated potassium exporter activity
M036_05160	COG0490	domain, Protein
M036_05170	COG1024	Enoyl-CoA hydratase
M036_05180	COG4152	abc transporter atp-binding protein
M036_05185	COG1668	transmembrane transport
M036_05190	COG0420	3'-5' exonuclease activity
M036_05195	COG4717	serine-type aminopeptidase activity
M036_05200	COG3481	metal-dependent phosphohydrolase, HD sub domain
M036_05210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M036_05235	COG1846	Transcriptional regulator
M036_05240	COG4980	gas vesicle protein
M036_05255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M036_05260	COG0537	adenosine 5'-monophosphoramidase activity
M036_05265	COG1131	(ABC) transporter
M036_05270	COG4473	ABC transporter
M036_05280	COG1473	amidohydrolase
M036_05285	COG3069	C4-dicarboxylate transmembrane transporter activity
M036_05290	COG2329	Antibiotic biosynthesis monooxygenase
M036_05295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M036_05300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M036_05315	COG1309	transcriptional regulator
M036_05320	COG1511	domain protein
M036_05325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M036_05330	COG4377	Putative membrane peptidase family (DUF2324)
M036_05340	COG1363	Peptidase, m42
M036_05345	COG4405	Protein conserved in bacteria
M036_05350	COG1301	dicarboxylic acid transport
M036_05360	COG1234	tRNA 3'-trailer cleavage
M036_05365	COG0095	Lipoate-protein ligase
M036_05370	COG0702	epimerase
M036_05375	COG0318	PFAM AMP-dependent synthetase and ligase
M036_05385	COG0501	Belongs to the peptidase M48B family
M036_05395	COG0456	acetyltransferase
M036_05400	COG0604	alcohol dehydrogenase
M036_05410	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M036_05415	COG0406	alpha-ribazole phosphatase activity
M036_05420	COG0183	Belongs to the thiolase family
M036_05425	COG0318	PFAM AMP-dependent synthetase and ligase
M036_05430	COG1268	BioY protein
M036_05435	COG0840	transmembrane signaling receptor activity
M036_05440	COG0723	plastoquinol--plastocyanin reductase activity
M036_05440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M036_05445	COG1028	Short-chain dehydrogenase reductase Sdr
M036_05455	COG4903	ComK protein
M036_05460	COG1028	Short-chain dehydrogenase reductase Sdr
M036_05470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M036_05485	COG0398	Pfam SNARE associated Golgi protein
M036_05490	COG0681	Belongs to the peptidase S26 family
M036_05495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M036_05500	COG1846	Transcriptional regulator
M036_05505	COG0738	Major facilitator superfamily
M036_05510	COG0673	inositol 2-dehydrogenase activity
M036_05515	COG0561	phosphatase activity
M036_05520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M036_05525	COG1609	Transcriptional regulator
M036_05530	COG3180	Ammonia monooxygenase
M036_05535	COG2814	Major facilitator Superfamily
M036_05535	COG0477	Major facilitator Superfamily
M036_05540	COG4533	DNA binding
M036_05550	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M036_05555	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M036_05560	COG1074	ATP-dependent DNA helicase activity
M036_05565	COG0420	3'-5' exonuclease activity
M036_05570	COG0419	ATPase involved in DNA repair
M036_05575	COG1403	HNH endonuclease
M036_05620	COG5337	Spore coat protein CotH
M036_05625	COG0179	Fumarylacetoacetate (FAA) hydrolase
M036_05635	COG1404	Belongs to the peptidase S8 family
M036_05645	COG0367	asparagine synthase
M036_05650	COG2318	DinB family
M036_05655	COG1562	ergosterol biosynthetic process
M036_05660	COG0534	Mate efflux family protein
M036_05665	COG1917	Cupin 2, conserved barrel domain protein
M036_05665	COG2207	Transcriptional regulator
M036_05670	COG1609	Transcriptional regulator
M036_05675	COG0673	inositol 2-dehydrogenase activity
M036_05680	COG2318	DinB family
M036_05685	COG1279	arginine transmembrane transporter activity
M036_05690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M036_05695	COG1357	PFAM Pentapeptide repeats (8 copies)
M036_05700	COG2267	carboxylic ester hydrolase activity
M036_05705	COG0529	Catalyzes the synthesis of activated sulfate
M036_05710	COG2046	Belongs to the sulfate adenylyltransferase family
M036_05715	COG0175	sulfate reduction
M036_05720	COG2045	Belongs to the ComB family
M036_05725	COG1809	phosphosulfolactate synthase activity
M036_05730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M036_05735	COG4948	Mandelate Racemase Muconate Lactonizing
M036_05740	COG2814	Major facilitator Superfamily
M036_05745	COG0454	-acetyltransferase
M036_05750	COG2153	protein acetylation
M036_05755	COG0646	methionine synthase
M036_05755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M036_05760	COG1666	GTP binding
M036_05765	COG2996	Protein conserved in bacteria
M036_05785	COG1695	Transcriptional regulator
M036_05800	COG3227	Zinc metalloprotease (Elastase)
M036_05805	COG1307	EDD domain protein, DegV family
M036_05810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M036_05830	COG0561	phosphatase activity
M036_05835	COG1073	alpha beta
M036_05840	COG2151	metal-sulfur cluster biosynthetic enzyme
M036_05850	COG0277	FAD linked oxidase domain protein
M036_05855	COG2271	Major facilitator Superfamily
M036_05860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M036_05875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M036_05880	COG0505	Belongs to the CarA family
M036_05885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M036_05890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M036_05905	COG2267	carboxylic ester hydrolase activity
M036_05915	COG1744	ABC transporter substrate-binding protein PnrA-like
M036_05930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M036_05935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M036_05940	COG5504	Zn-dependent protease
M036_05945	COG0444	Belongs to the ABC transporter superfamily
M036_05950	COG4608	Belongs to the ABC transporter superfamily
M036_05960	COG0601	transmembrane transport
M036_05965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M036_05975	COG0180	Tryptophanyl-tRNA synthetase
M036_05980	COG4166	transmembrane transport
M036_05985	COG0601	transmembrane transport
M036_05995	COG0456	acetyltransferase
M036_06000	COG1393	Belongs to the ArsC family
M036_06005	COG0861	Integral membrane protein TerC family
M036_06010	COG4862	establishment of competence for transformation
M036_06015	COG4469	Competence protein
M036_06020	COG1164	Oligoendopeptidase f
M036_06040	COG2346	COG2346, Truncated hemoglobins
M036_06045	COG0741	lytic transglycosylase activity
M036_06050	COG4116	CYTH
M036_06060	COG2357	RelA SpoT domain protein
M036_06065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M036_06070	COG0564	pseudouridine synthase activity
M036_06075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M036_06080	COG0475	glutathione-regulated potassium exporter activity
M036_06080	COG0569	domain protein
M036_06085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M036_06090	COG0352	thiamine-phosphate diphosphorylase activity
M036_06095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M036_06100	COG2104	thiamine diphosphate biosynthetic process
M036_06105	COG2022	thiamine diphosphate biosynthetic process
M036_06110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M036_06115	COG0351	phosphomethylpyrimidine kinase
M036_06120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M036_06180	COG0210	DNA helicase
M036_06190	COG2153	protein acetylation
M036_06195	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M036_06200	COG2382	esterase
M036_06205	COG0626	cystathionine gamma-synthase activity
M036_06210	COG0626	cystathionine gamma-synthase activity
M036_06215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M036_06220	COG5505	Protein of unknown function (DUF819)
M036_06245	COG5444	nuclease activity
M036_06275	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M036_06280	COG1028	Short-chain dehydrogenase reductase Sdr
M036_06290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M036_06290	COG3711	transcriptional antiterminator
M036_06295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M036_06295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M036_06295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M036_06300	COG1482	cell wall glycoprotein biosynthetic process
M036_06310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M036_06320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M036_06335	COG0109	protoheme IX farnesyltransferase activity
M036_06345	COG0726	polysaccharide deacetylase
M036_06365	COG5504	Zn-dependent protease
M036_06370	COG2205	protein histidine kinase activity
M036_06380	COG3383	formate dehydrogenase (NAD+) activity
M036_06385	COG2427	Protein of unknown function (DUF1641)
M036_06395	COG1051	belongs to the nudix hydrolase family
M036_06405	COG2124	cytochrome p450
M036_06410	COG1819	glycosyl
M036_06420	COG1587	Uroporphyrinogen-III synthase
M036_06425	COG0390	transport system, permease component
M036_06430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M036_06435	COG0697	spore germination
M036_06440	COG4297	protein containing double-stranded beta helix domain
M036_06450	COG1252	NADH dehydrogenase
M036_06460	COG1904	glucuronate isomerase
M036_06465	COG2211	Major facilitator Superfamily
M036_06470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M036_06475	COG1063	alcohol dehydrogenase
M036_06480	COG1312	Catalyzes the dehydration of D-mannonate
M036_06485	COG1028	Short-chain dehydrogenase reductase Sdr
M036_06490	COG2271	Major facilitator Superfamily
M036_06495	COG1609	Transcriptional regulator
M036_06500	COG0246	Mannitol dehydrogenase
M036_06505	COG2721	sulfolactate sulfo-lyase activity
M036_06510	COG0730	response to heat
M036_06515	COG2318	DinB family
M036_06520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M036_06525	COG0457	Tetratricopeptide repeat
M036_06535	COG2350	Protein conserved in bacteria
M036_06540	COG1388	LysM domain
M036_06540	COG5632	N-Acetylmuramoyl-L-alanine amidase
M036_06540	COG3409	Peptidoglycan-binding domain 1 protein
M036_06550	COG4195	phage-related replication protein
M036_06555	COG3546	catalase activity
M036_06560	COG2856	Zn peptidase
M036_06565	COG1396	sequence-specific DNA binding
M036_06575	COG1522	sequence-specific DNA binding
M036_06580	COG1484	DNA-dependent DNA replication
M036_06605	COG1595	DNA-templated transcription, initiation
M036_06610	COG5484	DNA packaging
M036_06610	COG3728	DNA packaging
M036_06615	COG1783	phage Terminase large subunit
M036_06620	COG5518	Phage portal protein
M036_06625	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M036_06630	COG4653	Phage capsid family
M036_06680	COG5412	phage tail tape measure protein
M036_06680	COG3953	SLT domain
M036_06685	COG1652	LysM domain
M036_06690	COG4193	domain, Protein
M036_06700	COG3628	GPW Gp25 family protein
M036_06705	COG3299	homolog of phage Mu protein gp47
M036_06710	COG3778	Protein conserved in bacteria
M036_06750	COG5632	N-Acetylmuramoyl-L-alanine amidase
M036_06750	COG3409	Peptidoglycan-binding domain 1 protein
M036_06765	COG0306	phosphate transporter
M036_06770	COG1392	Phosphate transport regulator
M036_06775	COG0531	amino acid
M036_06780	COG0346	lactoylglutathione lyase activity
M036_06785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M036_06790	COG0463	Glycosyl transferase, family 2
M036_06800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M036_06805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M036_06810	COG2362	D-Aminopeptidase
M036_06815	COG0601	transmembrane transport
M036_06820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M036_06825	COG0444	Belongs to the ABC transporter superfamily
M036_06830	COG4166	transmembrane transport
M036_06835	COG1619	proteins homologs of microcin C7 resistance protein MccF
M036_06840	COG4948	Mandelate Racemase Muconate Lactonizing
M036_06845	COG0791	NLP P60 protein
M036_06850	COG4608	Belongs to the ABC transporter superfamily
M036_06855	COG2706	6-phosphogluconolactonase activity
M036_06860	COG1834	amidinotransferase
M036_06865	COG1607	acyl-coa hydrolase
M036_06870	COG1017	nitric oxide dioxygenase activity
M036_06870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M036_06880	COG2323	membrane
M036_06885	COG2318	DinB family
M036_06890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M036_06895	COG2076	Multidrug Resistance protein
M036_06900	COG2076	Multidrug Resistance protein
M036_06905	COG0788	formyltetrahydrofolate deformylase activity
M036_06910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M036_06915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M036_06920	COG1764	response to oxidative stress
M036_06925	COG1846	Transcriptional regulator
M036_06930	COG1764	response to oxidative stress
M036_06940	COG0590	tRNA wobble adenosine to inosine editing
M036_06945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M036_06950	COG1404	Belongs to the peptidase S8 family
M036_06955	COG1366	Belongs to the anti-sigma-factor antagonist family
M036_06960	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M036_06965	COG1122	ATPase activity
M036_06970	COG4721	ABC-type cobalt transport system, permease component
M036_06980	COG0745	RESPONSE REGULATOR receiver
M036_06985	COG5002	protein histidine kinase activity
M036_06985	COG3850	Histidine kinase
M036_06990	COG3212	peptidase
M036_06995	COG3212	peptidase
M036_07010	COG2239	Acts as a magnesium transporter
M036_07015	COG0789	Transcriptional regulator
M036_07030	COG1846	Transcriptional regulator
M036_07035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M036_07040	COG0726	polysaccharide deacetylase
M036_07045	COG1408	metallophosphoesterase
M036_07055	COG0463	Glycosyl transferase, family 2
M036_07060	COG1793	dna ligase
M036_07060	COG3285	dna ligase
M036_07065	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M036_07070	COG5001	Diguanylate cyclase
M036_07070	COG3300	MHYT domain
M036_07075	COG0586	Pfam SNARE associated Golgi protein
M036_07080	COG0861	Integral membrane protein TerC family
M036_07085	COG1191	sigma factor activity
M036_07105	COG0501	Belongs to the peptidase M48B family
M036_07110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M036_07125	COG3594	Acyltransferase
M036_07130	COG5002	protein histidine kinase activity
M036_07135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M036_07145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M036_07150	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
M036_07155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M036_07160	COG0436	Aminotransferase
M036_07165	COG1850	ribulose-bisphosphate carboxylase activity
M036_07170	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
M036_07175	COG0235	Class ii aldolase
M036_07180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M036_07185	COG3339	Conserved Protein
M036_07200	COG3852	Histidine kinase
M036_07205	COG1846	Transcriptional regulator
M036_07210	COG1360	Flagellar Motor Protein
M036_07215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M036_07220	COG0542	response to heat
M036_07225	COG3949	Membrane
M036_07230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M036_07235	COG0720	synthase
M036_07240	COG0602	queuosine metabolic process
M036_07245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M036_07250	COG1733	regulation of RNA biosynthetic process
M036_07255	COG1028	Short-chain dehydrogenase reductase Sdr
M036_07260	COG4641	Protein conserved in bacteria
M036_07260	COG1388	LysM domain
M036_07265	COG1388	LysM domain
M036_07275	COG4873	Protein conserved in bacteria
M036_07285	COG3773	Cell wall hydrolase
M036_07290	COG2244	polysaccharide biosynthetic process
M036_07295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_07300	COG2217	Heavy metal translocating P-type atpase
M036_07310	COG0006	proline dipeptidase activity
M036_07320	COG1609	Transcriptional regulator
M036_07325	COG3711	transcriptional antiterminator
M036_07330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_07330	COG2190	(PTS) system
M036_07330	COG1263	PTS System
M036_07335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M036_07340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M036_07350	COG1533	DNA photolyase activity
M036_07355	COG0456	acetyltransferase
M036_07360	COG0840	transmembrane signaling receptor activity
M036_07365	COG2084	Dehydrogenase
M036_07370	COG2340	Cysteine-rich secretory protein family
M036_07375	COG0768	penicillin binding
M036_07380	COG4191	Histidine kinase
M036_07385	COG0436	Aminotransferase
M036_07395	COG0835	chemotaxis
M036_07395	COG0784	Response regulator, receiver
M036_07405	COG2814	Major facilitator Superfamily
M036_07410	COG1376	ErfK ybiS ycfS ynhG family protein
M036_07415	COG1408	metallophosphoesterase
M036_07420	COG1028	Short-chain dehydrogenase reductase Sdr
M036_07425	COG3409	Peptidoglycan-binding domain 1 protein
M036_07430	COG3409	Peptidoglycan-binding domain 1 protein
M036_07440	COG2200	EAL domain
M036_07450	COG4703	Protein of unknown function (DUF1797)
M036_07455	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M036_07465	COG0517	IMP dehydrogenase activity
M036_07470	COG0583	DNA-binding transcription factor activity
M036_07475	COG0716	FMN binding
M036_07485	COG0716	FMN binding
M036_07490	COG2171	N-acyltransferase activity
M036_07495	COG1473	amidohydrolase
M036_07505	COG0668	transmembrane transport
M036_07510	COG0450	alkyl hydroperoxide reductase
M036_07515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_07530	COG0746	molybdenum cofactor guanylyltransferase activity
M036_07535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M036_07540	COG0303	'Molybdopterin
M036_07545	COG1763	Mo-molybdopterin cofactor biosynthetic process
M036_07550	COG0314	molybdopterin synthase activity
M036_07555	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M036_07560	COG1132	(ABC) transporter
M036_07565	COG1132	(ABC) transporter
M036_07575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M036_07580	COG1136	(ABC) transporter
M036_07585	COG0577	efflux transmembrane transporter activity
M036_07590	COG1349	DNA-binding transcription factor activity
M036_07595	COG1105	Belongs to the carbohydrate kinase PfkB family
M036_07600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M036_07600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M036_07600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M036_07605	COG0681	Belongs to the peptidase S26 family
M036_07615	COG0488	(ABC) transporter
M036_07620	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M036_07625	COG2309	aminopeptidase activity
M036_07635	COG1077	Cell shape determining protein MreB Mrl
M036_07640	COG2002	toxin-antitoxin pair type II binding
M036_07645	COG3852	Histidine kinase
M036_07650	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M036_07650	COG2105	PFAM AIG2 family protein
M036_07655	COG0569	domain protein
M036_07660	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M036_07665	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M036_07675	COG0561	phosphatase activity
M036_07680	COG0242	peptide deformylase activity
M036_07690	COG0497	DNA recombination
M036_07695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M036_07700	COG0022	dehydrogenase e1 component
M036_07705	COG0508	dehydrogenase complex catalyzes the overall conversion of
M036_07710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M036_07715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_07720	COG1982	Orn Lys Arg decarboxylase major
M036_07725	COG4476	Belongs to the UPF0223 family
M036_07730	COG4493	Belongs to the UPF0637 family
M036_07740	COG0483	inositol monophosphate 1-phosphatase activity
M036_07750	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M036_07795	COG4896	Protein conserved in bacteria
M036_07805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M036_07810	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M036_07815	COG2066	Belongs to the glutaminase family
M036_07820	COG4838	Belongs to the UPF0358 family
M036_07825	COG0772	Belongs to the SEDS family
M036_07830	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M036_07835	COG1612	heme a metabolic process
M036_07840	COG0109	protoheme IX farnesyltransferase activity
M036_07845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M036_07845	COG2010	Cytochrome c
M036_07850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M036_07855	COG1845	cytochrome c oxidase, subunit III
M036_07860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M036_07865	COG3336	cytochrome c oxidase
M036_07875	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M036_07880	COG2340	Cysteine-rich secretory protein family
M036_07895	COG3679	Belongs to the UPF0342 family
M036_07900	COG4471	UPF0298 protein
M036_07905	COG0742	ribosomal rna small subunit methyltransferase
M036_07910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M036_07915	COG3314	Sporulation integral membrane protein YlbJ
M036_07920	COG1752	Esterase of the alpha-beta hydrolase superfamily
M036_07925	COG3480	Lon protease (S16) C-terminal proteolytic domain
M036_07930	COG1323	Belongs to the UPF0348 family
M036_07940	COG1399	metal-binding, possibly nucleic acid-binding protein
M036_07950	COG0454	-acetyltransferase
M036_07955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M036_07960	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M036_07965	COG2001	Belongs to the MraZ family
M036_07970	COG0275	rRNA processing
M036_07975	COG4839	cell division protein FtsL
M036_07985	COG0768	penicillin binding
M036_07995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M036_08005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M036_08010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M036_08015	COG0772	Belongs to the SEDS family
M036_08020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M036_08025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M036_08030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M036_08035	COG3879	Bacterial protein of unknown function (DUF881)
M036_08040	COG3879	Bacterial protein of unknown function (DUF881)
M036_08045	COG3856	small basic protein
M036_08050	COG0849	cell division
M036_08055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M036_08060	COG4412	M6 family metalloprotease domain protein
M036_08060	COG1404	Belongs to the peptidase S8 family
M036_08070	COG1191	sigma factor activity
M036_08075	COG1191	sigma factor activity
M036_08080	COG1119	ATPase activity
M036_08085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M036_08090	COG1873	PFAM PRC-barrel domain
M036_08100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M036_08105	COG1799	cell septum assembly
M036_08110	COG0762	integral membrane protein
M036_08115	COG2302	S4 RNA-binding domain
M036_08120	COG3599	regulation of cell shape
M036_08125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M036_08130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M036_08135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M036_08140	COG0564	pseudouridine synthase activity
M036_08145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M036_08150	COG2233	PERMEase
M036_08155	COG0540	Belongs to the ATCase OTCase family
M036_08160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M036_08165	COG0505	Belongs to the CarA family
M036_08170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M036_08175	COG0543	2 iron, 2 sulfur cluster binding
M036_08180	COG0167	dihydroorotate dehydrogenase activity
M036_08185	COG0284	orotidine-5'-phosphate decarboxylase activity
M036_08190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M036_08195	COG0175	sulfate reduction
M036_08200	COG0306	phosphate transporter
M036_08205	COG2046	Belongs to the sulfate adenylyltransferase family
M036_08210	COG0529	Catalyzes the synthesis of activated sulfate
M036_08215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M036_08220	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M036_08225	COG1648	precorrin-2 dehydrogenase activity
M036_08235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M036_08240	COG1561	YicC-like family, N-terminal region
M036_08245	COG2052	Domain of unknown function (DUF370)
M036_08250	COG0194	GDP metabolic process
M036_08255	COG1758	RNA polymerase activity
M036_08260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M036_08265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M036_08270	COG0242	peptide deformylase activity
M036_08275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M036_08280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M036_08280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M036_08285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M036_08290	COG0631	protein serine/threonine phosphatase activity
M036_08295	COG0515	serine threonine protein kinase
M036_08295	COG2815	serine threonine protein kinase
M036_08300	COG1162	GTPase activity
M036_08305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M036_08310	COG1564	THIamine pyrophosphokinase
M036_08320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M036_08325	COG1302	Protein conserved in bacteria
M036_08330	COG1461	Dihydroxyacetone kinase
M036_08335	COG1760	l-serine dehydratase
M036_08340	COG1760	l-serine dehydratase
M036_08345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M036_08350	COG1349	DNA-binding transcription factor activity
M036_08350	COG2050	protein possibly involved in aromatic compounds catabolism
M036_08355	COG0416	fatty acid biosynthetic process
M036_08360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M036_08365	COG1028	Short-chain dehydrogenase reductase Sdr
M036_08370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M036_08375	COG0571	ribonuclease III activity
M036_08380	COG1196	nuclear chromosome segregation
M036_08385	COG0552	protein localization to endoplasmic reticulum
M036_08395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M036_08400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M036_08405	COG0228	four-way junction DNA binding
M036_08410	COG1837	Belongs to the UPF0109 family
M036_08420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M036_08425	COG0336	Belongs to the RNA methyltransferase TrmD family
M036_08430	COG0335	large ribosomal subunit rRNA binding
M036_08435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M036_08440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M036_08450	COG2257	FlhB HrpN YscU SpaS Family
M036_08455	COG0045	succinate-CoA ligase (ADP-forming) activity
M036_08460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M036_08465	COG0758	DNA mediated transformation
M036_08470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M036_08475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M036_08480	COG4974	Belongs to the 'phage' integrase family
M036_08485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M036_08490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M036_08495	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M036_08500	COG1815	bacterial-type flagellum-dependent cell motility
M036_08505	COG1558	bacterial-type flagellum-dependent cell motility
M036_08510	COG1677	Flagellar hook-basal body complex protein FliE
M036_08515	COG1766	The M ring may be actively involved in energy transduction
M036_08520	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M036_08525	COG1317	bacterial-type flagellum organization
M036_08530	COG1157	protein secretion by the type III secretion system
M036_08535	COG2882	bacterial-type flagellum organization
M036_08540	COG3334	PFAM MgtE intracellular
M036_08545	COG3144	bacterial-type flagellum assembly
M036_08550	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M036_08555	COG4786	Flagellar basal body rod
M036_08560	COG1582	Flagellar protein (FlbD)
M036_08565	COG1580	Controls the rotational direction of flagella during chemotaxis
M036_08570	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M036_08575	COG1776	CheC inhibitor of MCP methylation
M036_08575	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M036_08580	COG2201	protein-glutamate methylesterase activity
M036_08585	COG3190	flagellar
M036_08590	COG1338	Plays a role in the flagellum-specific transport system
M036_08595	COG1987	bacterial-type flagellum assembly
M036_08600	COG1684	flagellar biosynthetic protein fliR
M036_08605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M036_08610	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M036_08615	COG1419	protein localization to endoplasmic reticulum
M036_08620	COG0455	bacterial-type flagellum organization
M036_08625	COG2201	protein-glutamate methylesterase activity
M036_08630	COG2198	Histidine kinase
M036_08630	COG0643	Histidine kinase
M036_08635	COG0835	chemotaxis
M036_08640	COG1776	CheC inhibitor of MCP methylation
M036_08645	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M036_08650	COG1191	sigma factor activity
M036_08660	COG0052	Belongs to the universal ribosomal protein uS2 family
M036_08665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M036_08670	COG0528	UMP kinase activity
M036_08675	COG0233	cytoplasmic translational termination
M036_08680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M036_08685	COG4589	Belongs to the CDS family
M036_08690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M036_08695	COG0750	zinc metalloprotease
M036_08700	COG0442	prolyl-tRNA aminoacylation
M036_08705	COG2176	DNA-directed DNA polymerase activity
M036_08710	COG0779	Required for maturation of 30S ribosomal subunits
M036_08715	COG0195	Participates in both transcription termination and antitermination
M036_08720	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M036_08725	COG1358	cellular component organization or biogenesis
M036_08730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M036_08735	COG1550	Protein conserved in bacteria
M036_08740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M036_08745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M036_08750	COG0196	riboflavin kinase activity
M036_08755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M036_08760	COG1185	polyribonucleotide nucleotidyltransferase activity
M036_08765	COG0726	polysaccharide deacetylase
M036_08770	COG0612	Peptidase, M16
M036_08775	COG1873	PFAM PRC-barrel domain
M036_08785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M036_08790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M036_08795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M036_08800	COG0527	aspartate kinase activity
M036_08805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M036_08810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M036_08815	COG0740	serine-type endopeptidase activity
M036_08825	COG1674	ftsk spoiiie
M036_08825	COG4980	gas vesicle protein
M036_08830	COG2188	Transcriptional regulator
M036_08835	COG2814	Major facilitator Superfamily
M036_08840	COG0612	Peptidase, M16
M036_08845	COG0612	Peptidase, M16
M036_08850	COG0300	oxidoreductase activity
M036_08865	COG1426	Protein conserved in bacteria
M036_08870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M036_08875	COG1058	Belongs to the CinA family
M036_08875	COG1546	Belongs to the CinA family
M036_08880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M036_08885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M036_08890	COG1418	mRNA catabolic process
M036_08895	COG1692	metallophosphoesterase
M036_08900	COG2359	stage V sporulation protein S
M036_08905	COG1063	alcohol dehydrogenase
M036_08910	COG0156	8-amino-7-oxononanoate synthase activity
M036_08915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M036_08920	COG4550	Control of competence regulator ComK, YlbF/YmcA
M036_08930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M036_08935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M036_08960	COG3226	Transcriptional regulator
M036_08965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M036_08975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M036_08980	COG3321	synthase
M036_08985	COG2070	2-Nitropropane dioxygenase
M036_08985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M036_08990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M036_08995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M036_09000	COG3425	synthase
M036_09005	COG1024	Enoyl-CoA hydratase
M036_09010	COG1024	Enoyl-CoA hydratase
M036_09015	COG3321	synthase
M036_09015	COG1028	Short-chain dehydrogenase reductase Sdr
M036_09015	COG0300	oxidoreductase activity
M036_09015	COG0318	PFAM AMP-dependent synthetase and ligase
M036_09015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_09020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M036_09020	COG0300	oxidoreductase activity
M036_09020	COG4221	oxidoreductase activity
M036_09020	COG3321	synthase
M036_09025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M036_09025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_09025	COG1028	Short-chain dehydrogenase reductase Sdr
M036_09025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M036_09025	COG3321	synthase
M036_09030	COG3321	synthase
M036_09030	COG1028	Short-chain dehydrogenase reductase Sdr
M036_09030	COG4221	oxidoreductase activity
M036_09030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_09035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M036_09035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M036_09035	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M036_09035	COG3321	synthase
M036_09040	COG2124	cytochrome p450
M036_09050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M036_09055	COG1404	Belongs to the peptidase S8 family
M036_09065	COG4195	phage-related replication protein
M036_09070	COG1764	response to oxidative stress
M036_09075	COG2076	Multidrug Resistance protein
M036_09080	COG2076	Multidrug Resistance protein
M036_09095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M036_09100	COG1923	regulation of RNA biosynthetic process
M036_09115	COG1780	Probably involved in ribonucleotide reductase function
M036_09120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M036_09125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M036_09130	COG4112	unkown
M036_09135	COG0860	N-Acetylmuramoyl-L-alanine amidase
M036_09140	COG0464	growth
M036_09150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M036_09155	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M036_09160	COG0789	Transcriptional regulator
M036_09165	COG0174	glutamine synthetase
M036_09185	COG4282	regulation of fungal-type cell wall biogenesis
M036_09195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M036_09220	COG0135	phosphoribosylanthranilate isomerase activity
M036_09225	COG2211	Major facilitator Superfamily
M036_09230	COG3507	Belongs to the glycosyl hydrolase 43 family
M036_09235	COG1940	carbohydrate kinase activity
M036_09240	COG2115	Belongs to the xylose isomerase family
M036_09245	COG1070	Carbohydrate kinase
M036_09250	COG1525	nuclease
M036_09255	COG2814	Major facilitator Superfamily
M036_09260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M036_09270	COG0756	dUTP diphosphatase activity
M036_09305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M036_09320	COG3832	glyoxalase III activity
M036_09330	COG0697	spore germination
M036_09335	COG0531	amino acid
M036_09365	COG4195	phage-related replication protein
M036_09375	COG0346	lactoylglutathione lyase activity
M036_09385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M036_09390	COG1388	LysM domain
M036_09395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M036_09400	COG4224	UPF0291 protein
M036_09405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M036_09415	COG3763	UPF0154 protein
M036_09425	COG0785	Cytochrome C biogenesis protein
M036_09430	COG2201	protein-glutamate methylesterase activity
M036_09435	COG4846	Membrane protein involved in cytochrome C biogenesis
M036_09445	COG0071	Belongs to the small heat shock protein (HSP20) family
M036_09460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M036_09465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_09485	COG0824	Thioesterase
M036_09495	COG4841	protein insertion into membrane
M036_09500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M036_09505	COG1832	CoA-binding protein
M036_09510	COG0187	DNA topoisomerase II activity
M036_09515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M036_09530	COG1115	amino acid carrier protein
M036_09535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M036_09545	COG5520	Belongs to the glycosyl hydrolase 30 family
M036_09550	COG3507	Belongs to the glycosyl hydrolase 43 family
M036_09560	COG2246	polysaccharide biosynthetic process
M036_09565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M036_09570	COG0586	Pfam SNARE associated Golgi protein
M036_09575	COG2404	hydrolase activity, acting on ester bonds
M036_09580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M036_09585	COG1024	Enoyl-CoA hydratase
M036_09590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M036_09595	COG0511	ligase activity, forming carbon-carbon bonds
M036_09600	COG0439	Biotin carboxylase
M036_09605	COG0318	PFAM AMP-dependent synthetase and ligase
M036_09610	COG1960	acyl-CoA dehydrogenase activity
M036_09625	COG1649	PFAM Uncharacterised BCR, COG1649
M036_09635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_09635	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M036_09650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_09655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_09660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_09665	COG2027	D-alanyl-D-alanine carboxypeptidase
M036_09670	COG2017	converts alpha-aldose to the beta-anomer
M036_09675	COG0534	Mate efflux family protein
M036_09690	COG0582	viral genome integration into host DNA
M036_09695	COG0166	Belongs to the GPI family
M036_09700	COG0405	Gamma-glutamyltransferase
M036_09705	COG0583	DNA-binding transcription factor activity
M036_09710	COG0604	alcohol dehydrogenase
M036_09715	COG0493	'glutamate synthase
M036_09720	COG0067	glutamate synthase
M036_09720	COG0070	glutamate synthase
M036_09720	COG0069	glutamate synthase activity
M036_09725	COG0583	DNA-binding transcription factor activity
M036_09730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M036_09735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M036_09745	COG0300	oxidoreductase activity
M036_09750	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M036_09760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M036_09765	COG2814	Major facilitator Superfamily
M036_09770	COG1070	Carbohydrate kinase
M036_09775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M036_09780	COG0243	molybdopterin cofactor binding
M036_09805	COG5278	phosphoserine phosphatase activity
M036_09805	COG0840	transmembrane signaling receptor activity
M036_09810	COG2368	4-hydroxyphenylacetate
M036_09815	COG4305	rare lipoprotein A
M036_09820	COG3619	membrane
M036_09825	COG3866	Pectate lyase
M036_09830	COG2135	peptidase activity
M036_09845	COG2140	Oxalate decarboxylase
M036_09855	COG0456	acetyltransferase
M036_09870	COG2720	vancomycin resistance protein
M036_09880	COG3655	Transcriptional regulator
M036_09885	COG3739	integral membrane protein
M036_09890	COG0583	DNA-binding transcription factor activity
M036_09895	COG0697	spore germination
M036_09905	COG0693	protein deglycase activity
M036_09910	COG2367	Beta-lactamase
M036_09930	COG3848	Pyruvate phosphate dikinase
M036_09930	COG0574	Belongs to the PEP-utilizing enzyme family
M036_09935	COG0726	polysaccharide deacetylase
M036_09940	COG2314	TM2 domain
M036_09945	COG1396	sequence-specific DNA binding
M036_09960	COG2135	peptidase activity
M036_09965	COG1793	dna ligase
M036_09995	COG0457	Tetratricopeptide repeat
M036_10020	COG5290	Psort location Cytoplasmic, score
M036_10040	COG5444	nuclease activity
M036_10045	COG4282	regulation of fungal-type cell wall biogenesis
M036_10050	COG1231	oxidoreductase activity
M036_10055	COG5434	Belongs to the glycosyl hydrolase 28 family
M036_10060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M036_10065	COG0662	Cupin 2, conserved barrel domain protein
M036_10065	COG2207	Transcriptional regulator
M036_10070	COG0456	acetyltransferase
M036_10075	COG1309	transcriptional regulator
M036_10080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M036_10085	COG3708	Transcriptional regulator
M036_10090	COG2378	regulation of single-species biofilm formation
M036_10100	COG0640	Transcriptional regulator
M036_10105	COG0741	lytic transglycosylase activity
M036_10110	COG2322	membrane
M036_10125	COG1619	proteins homologs of microcin C7 resistance protein MccF
M036_10130	COG3239	Fatty acid desaturase
M036_10135	COG4585	Histidine kinase
M036_10140	COG2197	response regulator
M036_10145	COG1388	LysM domain
M036_10145	COG3584	3D domain protein
M036_10150	COG0514	ATP-dependent DNA helicase (RecQ)
M036_10160	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M036_10165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M036_10180	COG0071	Belongs to the small heat shock protein (HSP20) family
M036_10210	COG1012	belongs to the aldehyde dehydrogenase family
M036_10215	COG1657	PFAM Prenyltransferase squalene oxidase
M036_10220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M036_10225	COG0733	neurotransmitter:sodium symporter activity
M036_10230	COG0385	Bile acid
M036_10235	COG0508	dehydrogenase complex catalyzes the overall conversion of
M036_10240	COG0567	Dehydrogenase, E1 component
M036_10245	COG4548	von Willebrand factor, type A
M036_10250	COG0714	Associated with various cellular activities
M036_10255	COG2032	superoxide dismutase activity
M036_10260	COG1388	LysM domain
M036_10260	COG0791	NLP P60 protein
M036_10265	COG1819	glycosyl
M036_10270	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M036_10280	COG0534	Mate efflux family protein
M036_10285	COG1366	Belongs to the anti-sigma-factor antagonist family
M036_10290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M036_10295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M036_10305	COG2962	Rard protein
M036_10320	COG2610	gluconate transmembrane transporter activity
M036_10325	COG1942	4-Oxalocrotonate Tautomerase
M036_10330	COG1733	regulation of RNA biosynthetic process
M036_10335	COG0778	Nitroreductase
M036_10340	COG0400	carboxylic ester hydrolase activity
M036_10345	COG0346	lactoylglutathione lyase activity
M036_10355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M036_10360	COG3409	Peptidoglycan-binding domain 1 protein
M036_10360	COG0793	Belongs to the peptidase S41A family
M036_10365	COG2226	methyltransferase
M036_10375	COG1876	peptidase activity
M036_10380	COG0813	purine-nucleoside phosphorylase activity
M036_10395	COG0671	phosphoesterase, PA-phosphatase related
M036_10415	COG4479	Belongs to the UPF0346 family
M036_10425	COG1509	lysine 2,3-aminomutase activity
M036_10430	COG0456	acetyltransferase
M036_10435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M036_10440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M036_10445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M036_10450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M036_10465	COG0456	acetyltransferase
M036_10470	COG0463	Glycosyl transferase, family 2
M036_10485	COG4641	Protein conserved in bacteria
M036_10490	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
M036_10495	COG1086	Polysaccharide biosynthesis protein
M036_10500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M036_10505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M036_10510	COG1846	Transcriptional regulator
M036_10515	COG0534	Mate efflux family protein
M036_10525	COG4698	Protein conserved in bacteria
M036_10530	COG2755	lipolytic protein G-D-S-L family
M036_10535	COG1999	signal sequence binding
M036_10545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M036_10550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M036_10555	COG1272	protein, Hemolysin III
M036_10560	COG0204	Acyl-transferase
M036_10565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M036_10570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M036_10575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M036_10585	COG2521	methyltransferase
M036_10585	COG2136	Putative SAM-dependent methyltransferase
M036_10595	COG0129	dihydroxy-acid dehydratase activity
M036_10600	COG1413	lyase activity
M036_10605	COG1418	mRNA catabolic process
M036_10610	COG0386	Belongs to the glutathione peroxidase family
M036_10615	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M036_10620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M036_10625	COG1278	Cold shock
M036_10645	COG0328	RNA-DNA hybrid ribonuclease activity
M036_10650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M036_10655	COG0328	RNA-DNA hybrid ribonuclease activity
M036_10665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M036_10685	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M036_10690	COG1755	Isoprenylcysteine carboxyl methyltransferase
M036_10695	COG3424	synthase
M036_10700	COG2233	PERMEase
M036_10705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M036_10710	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M036_10720	COG0800	Aldolase
M036_10725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M036_10730	COG1609	Transcriptional regulator
M036_10735	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M036_10740	COG1028	Short-chain dehydrogenase reductase Sdr
M036_10745	COG1199	ATP-dependent helicase activity
M036_10755	COG0116	Belongs to the methyltransferase superfamily
M036_10765	COG4474	Belongs to the UPF0398 family
M036_10775	COG3359	exonuclease
M036_10780	COG1205	dead DEAH box helicase
M036_10780	COG1111	helicase
M036_10785	COG2190	(PTS) system
M036_10790	COG0071	Belongs to the small heat shock protein (HSP20) family
M036_10825	COG3331	DNA recombination
M036_10830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M036_10830	COG4499	WXG100 protein secretion system (Wss), protein YukC
M036_10840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M036_10845	COG3935	DnaD domain protein
M036_10850	COG0017	Asparaginyl-tRNA synthetase
M036_10855	COG0436	Aminotransferase
M036_10860	COG5353	protein conserved in bacteria
M036_10870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M036_10870	COG1199	ATP-dependent helicase activity
M036_10875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M036_10880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M036_10885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M036_10890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M036_10890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M036_10895	COG0617	tRNA 3'-terminal CCA addition
M036_10900	COG0438	transferase activity, transferring glycosyl groups
M036_10905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M036_10910	COG1803	Methylglyoxal synthase
M036_10915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M036_10920	COG1694	Mazg nucleotide pyrophosphohydrolase
M036_10925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M036_10935	COG4347	Protein of unknown function (DUF1405)
M036_10940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M036_10940	COG2010	Cytochrome c
M036_10945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M036_10950	COG0723	plastoquinol--plastocyanin reductase activity
M036_10960	COG5582	Belongs to the UPF0302 family
M036_10965	COG0457	Tetratricopeptide repeat
M036_10970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M036_10975	COG0287	Prephenate dehydrogenase
M036_10980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M036_10985	COG0159	tryptophan synthase activity
M036_10990	COG0133	tryptophan synthase activity
M036_10995	COG0135	phosphoribosylanthranilate isomerase activity
M036_11005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M036_11010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M036_11015	COG4401	Chorismate mutase type I
M036_11020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M036_11025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M036_11030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M036_11040	COG0105	UTP biosynthetic process
M036_11045	COG0142	geranyltranstransferase activity
M036_11050	COG2226	methyltransferase
M036_11055	COG0142	geranyltranstransferase activity
M036_11065	COG0302	gtp cyclohydrolase
M036_11070	COG0776	regulation of translation
M036_11075	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M036_11090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M036_11095	COG1160	GTP binding
M036_11120	COG1304	FMN binding
M036_11125	COG0539	negative regulation of cytoplasmic translation
M036_11130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M036_11140	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M036_11145	COG2959	enzyme of heme biosynthesis
M036_11150	COG3409	Peptidoglycan-binding domain 1 protein
M036_11150	COG3773	Cell wall hydrolase
M036_11155	COG2339	peptidase activity
M036_11160	COG0492	ferredoxin-NADP+ reductase activity
M036_11165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M036_11170	COG4862	establishment of competence for transformation
M036_11175	COG1408	metallophosphoesterase
M036_11185	COG1388	LysM domain
M036_11190	COG1266	CAAX protease self-immunity
M036_11195	COG0514	ATP-dependent DNA helicase (RecQ)
M036_11200	COG4955	Helix-turn-helix domain
M036_11205	COG1141	Ferredoxin
M036_11210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M036_11220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M036_11225	COG0710	3-dehydroquinate dehydratase activity
M036_11235	COG1595	DNA-templated transcription, initiation
M036_11240	COG5002	protein histidine kinase activity
M036_11245	COG0745	RESPONSE REGULATOR receiver
M036_11250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M036_11255	COG1333	cytochrome c biogenesis protein
M036_11260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_11265	COG1187	pseudouridine synthase activity
M036_11270	COG0700	Nucleoside recognition
M036_11275	COG2715	membrane protein required for spore maturation
M036_11280	COG1686	Belongs to the peptidase S11 family
M036_11290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M036_11295	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M036_11300	COG1547	Domain of unknown function (DUF309)
M036_11305	COG0456	acetyltransferase
M036_11310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M036_11315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M036_11315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M036_11320	COG0307	riboflavin synthase, alpha
M036_11325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M036_11325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M036_11340	COG0681	Belongs to the peptidase S26 family
M036_11345	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
M036_11365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M036_11370	COG4086	secreted protein
M036_11375	COG0019	diaminopimelate decarboxylase activity
M036_11380	COG0697	spore germination
M036_11395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M036_11415	COG1191	sigma factor activity
M036_11420	COG2172	sigma factor antagonist activity
M036_11425	COG1366	Belongs to the anti-sigma-factor antagonist family
M036_11430	COG1686	Belongs to the peptidase S11 family
M036_11435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M036_11440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M036_11445	COG4974	Belongs to the 'phage' integrase family
M036_11455	COG0735	belongs to the Fur family
M036_11460	COG1300	Membrane
M036_11470	COG0281	malic enzyme
M036_11475	COG1757	Na H antiporter
M036_11480	COG1027	Aspartate ammonia-lyase
M036_11485	COG0252	asparaginase activity
M036_11490	COG1396	sequence-specific DNA binding
M036_11495	COG1379	DNA repair
M036_11500	COG0494	nUDIX hydrolase
M036_11510	COG0667	Aldo Keto reductase
M036_11520	COG1073	alpha beta
M036_11530	COG4918	Iron-sulphur cluster biosynthesis
M036_11535	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M036_11535	COG0456	acetyltransferase
M036_11540	COG2329	Antibiotic biosynthesis monooxygenase
M036_11545	COG0456	acetyltransferase
M036_11555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M036_11565	COG2211	Major facilitator Superfamily
M036_11575	COG0346	lactoylglutathione lyase activity
M036_11580	COG1072	(Pantothenic acid kinase))
M036_11585	COG3048	D-serine ammonia-lyase activity
M036_11590	COG0300	oxidoreductase activity
M036_11595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M036_11600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M036_11605	COG4187	Peptidase family M20/M25/M40
M036_11610	COG1902	pentaerythritol trinitrate reductase activity
M036_11615	COG0596	Alpha beta hydrolase
M036_11625	COG1234	tRNA 3'-trailer cleavage
M036_11630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M036_11635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M036_11640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M036_11650	COG0706	membrane insertase activity
M036_11655	COG3361	conserved protein (COG2071)
M036_11660	COG2195	Cleaves the N-terminal amino acid of tripeptides
M036_11665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M036_11670	COG0346	lactoylglutathione lyase activity
M036_11680	COG1376	ErfK ybiS ycfS ynhG family protein
M036_11685	COG4129	membrane
M036_11690	COG1126	abc transporter atp-binding protein
M036_11695	COG0765	amino acid transport
M036_11700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M036_11710	COG1597	lipid kinase activity
M036_11715	COG2814	Major facilitator Superfamily
M036_11720	COG4978	Transcriptional regulator
M036_11720	COG0789	Transcriptional regulator
M036_11725	COG0508	dehydrogenase complex catalyzes the overall conversion of
M036_11730	COG0022	dehydrogenase e1 component
M036_11735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M036_11740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M036_11745	COG3426	butyrate kinase activity
M036_11750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M036_11755	COG0280	phosphate acetyltransferase
M036_11760	COG3829	transcription factor binding
M036_11760	COG3290	protein histidine kinase activity
M036_11770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M036_11775	COG2079	MmgE PrpD family protein
M036_11780	COG0372	Belongs to the citrate synthase family
M036_11785	COG1960	acyl-CoA dehydrogenase activity
M036_11790	COG1250	3-hydroxyacyl-CoA dehydrogenase
M036_11795	COG0183	Belongs to the thiolase family
M036_11800	COG0584	glycerophosphoryl diester phosphodiesterase
M036_11805	COG0860	N-Acetylmuramoyl-L-alanine amidase
M036_11820	COG1902	pentaerythritol trinitrate reductase activity
M036_11830	COG0745	RESPONSE REGULATOR receiver
M036_11840	COG0750	zinc metalloprotease
M036_11845	COG0497	DNA recombination
M036_11850	COG1438	arginine binding
M036_11855	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M036_11860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M036_11865	COG0142	geranyltranstransferase activity
M036_11870	COG1722	exodeoxyribonuclease VII activity
M036_11875	COG1570	exodeoxyribonuclease VII activity
M036_11880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M036_11885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M036_11890	COG1302	Protein conserved in bacteria
M036_11895	COG0439	Biotin carboxylase
M036_11900	COG0511	ligase activity, forming carbon-carbon bonds
M036_11940	COG3854	ATPases associated with a variety of cellular activities
M036_11950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M036_11955	COG0006	proline dipeptidase activity
M036_11960	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M036_11970	COG3872	metal-dependent enzyme
M036_11980	COG1752	Esterase of the alpha-beta hydrolase superfamily
M036_11985	COG1321	iron dependent repressor
M036_11990	COG0095	Lipoate-protein ligase
M036_11995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M036_12000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M036_12005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M036_12010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M036_12015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M036_12030	COG1396	sequence-specific DNA binding
M036_12040	COG0681	Belongs to the peptidase S26 family
M036_12065	COG4940	Competence protein ComGF
M036_12075	COG4970	Tfp pilus assembly protein FimT
M036_12080	COG4537	Required for transformation and DNA binding
M036_12085	COG1459	type II secretion system
M036_12090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M036_12105	COG0598	Magnesium transport protein CorA
M036_12110	COG1253	flavin adenine dinucleotide binding
M036_12115	COG1366	Belongs to the anti-sigma-factor antagonist family
M036_12125	COG1393	Belongs to the ArsC family
M036_12135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M036_12145	COG0011	TIGRFAM Protein of
M036_12155	COG2866	Carboxypeptidase
M036_12160	COG1368	sulfuric ester hydrolase activity
M036_12165	COG1940	carbohydrate kinase activity
M036_12170	COG4483	Protein conserved in bacteria
M036_12175	COG0457	Tetratricopeptide repeat
M036_12175	COG0705	Rhomboid family
M036_12185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M036_12190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M036_12210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M036_12215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M036_12220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M036_12225	COG0581	inorganic phosphate transmembrane transporter activity
M036_12230	COG0573	inorganic phosphate transmembrane transporter activity
M036_12235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M036_12245	COG0477	Major facilitator Superfamily
M036_12250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M036_12255	COG2839	Protein conserved in bacteria
M036_12260	COG5521	maltodextrose utilization protein MalA
M036_12270	COG1388	LysM domain
M036_12275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M036_12280	COG4709	membrane
M036_12285	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M036_12295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M036_12305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M036_12310	COG0513	Belongs to the DEAD box helicase family
M036_12320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M036_12325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M036_12330	COG2384	SAM-dependent methyltransferase
M036_12335	COG2010	Cytochrome c
M036_12340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M036_12345	COG0358	DNA primase activity
M036_12350	COG1671	Belongs to the UPF0178 family
M036_12355	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M036_12360	COG0517	IMP dehydrogenase activity
M036_12365	COG0751	glycine-tRNA ligase activity
M036_12370	COG0752	glycyl-tRNA synthetase alpha subunit
M036_12375	COG1381	Involved in DNA repair and RecF pathway recombination
M036_12385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M036_12390	COG0295	cytidine deaminase activity
M036_12395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M036_12400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M036_12405	COG1480	7TM receptor with intracellular HD hydrolase
M036_12415	COG1702	phosphate starvation-inducible protein PhoH
M036_12420	COG0561	phosphatase activity
M036_12435	COG4864	UPF0365 protein
M036_12440	COG1030	water channel activity
M036_12445	COG1610	YqeY-like protein
M036_12450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M036_12455	COG1283	sodium-dependent phosphate transmembrane transporter activity
M036_12460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M036_12465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M036_12470	COG2264	protein methyltransferase activity
M036_12475	COG0484	heat shock protein binding
M036_12480	COG0443	Heat shock 70 kDa protein
M036_12485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M036_12490	COG1420	regulation of RNA biosynthetic process
M036_12495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M036_12500	COG0481	GTPase activity
M036_12510	COG0860	N-Acetylmuramoyl-L-alanine amidase
M036_12515	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M036_12520	COG0268	Binds directly to 16S ribosomal RNA
M036_12525	COG1466	dna polymerase III delta subunit
M036_12535	COG0658	competence protein
M036_12535	COG2333	competence protein COMEC
M036_12540	COG2131	deaminase
M036_12545	COG1596	polysaccharide export
M036_12545	COG1555	photosystem II stabilization
M036_12550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M036_12555	COG2226	methyltransferase
M036_12560	COG0799	negative regulation of ribosome biogenesis
M036_12565	COG1713	HD superfamily hydrolase involved in NAD metabolism
M036_12570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M036_12575	COG1534	Rna-binding protein
M036_12580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M036_12585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M036_12590	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M036_12605	COG2755	lipolytic protein G-D-S-L family
M036_12610	COG5632	N-Acetylmuramoyl-L-alanine amidase
M036_12610	COG3409	Peptidoglycan-binding domain 1 protein
M036_12615	COG0398	Pfam SNARE associated Golgi protein
M036_12620	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M036_12630	COG3209	COG3209 Rhs family protein
M036_12635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M036_12640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M036_12645	COG0798	PFAM Bile acid sodium symporter
M036_12650	COG0346	lactoylglutathione lyase activity
M036_12655	COG0640	Transcriptional regulator
M036_12660	COG3403	YqcI/YcgG family
M036_12665	COG0457	Tetratricopeptide repeat
M036_12680	COG5444	nuclease activity
M036_12705	COG5632	N-Acetylmuramoyl-L-alanine amidase
M036_12705	COG3409	Peptidoglycan-binding domain 1 protein
M036_12710	COG4824	toxin secretion phage lysis holin
M036_12740	COG3778	Protein conserved in bacteria
M036_12745	COG3299	homolog of phage Mu protein gp47
M036_12750	COG3628	GPW Gp25 family protein
M036_12760	COG4193	domain, Protein
M036_12765	COG1652	LysM domain
M036_12770	COG3953	SLT domain
M036_12770	COG5280	Phage tail tape measure protein TP901
M036_12835	COG4653	Phage capsid family
M036_12840	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M036_12850	COG2369	cell adhesion
M036_12855	COG5518	Phage portal protein
M036_12860	COG1783	phage Terminase large subunit
M036_12865	COG5484	DNA packaging
M036_12875	COG3677	Transposase
M036_12890	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
M036_12900	COG1484	DNA-dependent DNA replication
M036_12905	COG3935	DnaD domain protein
M036_12910	COG3723	Recombinational DNA repair protein, rece pathway
M036_12915	COG5377	YqaJ viral recombinase family
M036_12940	COG1476	TRANSCRIPTIONal
M036_12945	COG3620	sequence-specific DNA binding
M036_12955	COG0563	adenylate kinase activity
M036_12960	COG2856	Zn peptidase
M036_12975	COG3223	Belongs to the PsiE family
M036_12980	COG5002	protein histidine kinase activity
M036_12980	COG0642	Histidine kinase
M036_12985	COG0745	RESPONSE REGULATOR receiver
M036_12990	COG2311	Membrane
M036_13000	COG0454	-acetyltransferase
M036_13005	COG2249	NAD(P)H dehydrogenase (quinone) activity
M036_13015	COG0730	response to heat
M036_13020	COG0425	Belongs to the sulfur carrier protein TusA family
M036_13025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M036_13025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M036_13035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M036_13035	COG0425	Belongs to the sulfur carrier protein TusA family
M036_13040	COG2210	Belongs to the sulfur carrier protein TusA family
M036_13045	COG1937	Protein conserved in bacteria
M036_13050	COG0662	Cupin 2, conserved barrel domain protein
M036_13060	COG4978	Transcriptional regulator
M036_13060	COG0789	Transcriptional regulator
M036_13065	COG2814	Major facilitator Superfamily
M036_13070	COG0456	acetyltransferase
M036_13075	COG1253	flavin adenine dinucleotide binding
M036_13085	COG0697	spore germination
M036_13090	COG0583	DNA-binding transcription factor activity
M036_13095	COG2072	flavoprotein involved in K transport
M036_13100	COG1230	cation diffusion facilitator family transporter
M036_13105	COG1942	4-Oxalocrotonate Tautomerase
M036_13110	COG0583	DNA-binding transcription factor activity
M036_13120	COG1114	Component of the transport system for branched-chain amino acids
M036_13125	COG1687	branched-chain amino acid
M036_13130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M036_13135	COG1522	sequence-specific DNA binding
M036_13140	COG2732	(Barnase) inhibitor
M036_13145	COG2124	cytochrome p450
M036_13155	COG1335	isochorismatase
M036_13165	COG2318	DinB family
M036_13175	COG2070	2-Nitropropane dioxygenase
M036_13180	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M036_13200	COG3443	Belongs to the bacterial solute-binding protein 9 family
M036_13205	COG1595	DNA-templated transcription, initiation
M036_13210	COG0667	Aldo Keto reductase
M036_13215	COG2851	Citrate transporter
M036_13220	COG0583	DNA-binding transcription factor activity
M036_13225	COG2828	Protein conserved in bacteria
M036_13230	COG3409	Peptidoglycan-binding domain 1 protein
M036_13240	COG5566	PFAM Mor transcription activator
M036_13245	COG0596	Alpha beta hydrolase
M036_13250	COG4991	sh3 domain protein
M036_13255	COG4991	sh3 domain protein
M036_13260	COG0346	lactoylglutathione lyase activity
M036_13270	COG5577	PFAM Coat F domain
M036_13275	COG1063	alcohol dehydrogenase
M036_13285	COG5577	PFAM Coat F domain
M036_13290	COG0789	Transcriptional regulator
M036_13300	COG1064	alcohol dehydrogenase
M036_13305	COG0693	protein deglycase activity
M036_13310	COG1621	beta-fructofuranosidase activity
M036_13315	COG3716	PTS system mannose fructose sorbose family IID component
M036_13320	COG3715	PTS system
M036_13325	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_13330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M036_13335	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M036_13335	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M036_13340	COG1113	amino acid transport
M036_13345	COG1280	lysine exporter protein (LysE YggA)
M036_13350	COG1378	Sugar-specific transcriptional regulator TrmB
M036_13355	COG1595	DNA-templated transcription, initiation
M036_13365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M036_13365	COG2755	lipolytic protein G-D-S-L family
M036_13375	COG2124	cytochrome p450
M036_13375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M036_13385	COG2226	methyltransferase
M036_13400	COG2116	formate transmembrane transporter activity
M036_13405	COG5609	conserved protein (DUF2294)
M036_13410	COG3383	formate dehydrogenase (NAD+) activity
M036_13415	COG2427	Protein of unknown function (DUF1641)
M036_13425	COG0626	cystathionine gamma-synthase activity
M036_13430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M036_13435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M036_13440	COG2226	methyltransferase
M036_13455	COG0768	penicillin binding
M036_13460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M036_13490	COG1388	LysM domain
M036_13490	COG5632	N-Acetylmuramoyl-L-alanine amidase
M036_13490	COG3409	Peptidoglycan-binding domain 1 protein
M036_13495	COG4824	toxin secretion phage lysis holin
M036_13515	COG5434	Belongs to the glycosyl hydrolase 28 family
M036_13520	COG3942	CHAP domain
M036_13520	COG1705	Flagellar rod assembly protein muramidase FlgJ
M036_13650	COG0582	viral genome integration into host DNA
M036_13760	COG1396	sequence-specific DNA binding
M036_13775	COG4974	Belongs to the 'phage' integrase family
M036_13780	COG0572	uridine kinase
M036_13800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M036_13805	COG3906	Belongs to the UPF0473 family
M036_13810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M036_13815	COG4472	Bacterial protein of unknown function (DUF965)
M036_13820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M036_13825	COG0628	permease
M036_13830	COG1126	abc transporter atp-binding protein
M036_13835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M036_13840	COG0765	amino acid transport
M036_13845	COG0765	amino acid transport
M036_13860	COG3881	PFAM PRC-barrel domain
M036_13865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M036_13870	COG0457	Tetratricopeptide repeat
M036_13875	COG0482	sulfurtransferase activity
M036_13880	COG1104	cysteine desulfurase activity
M036_13885	COG1959	2 iron, 2 sulfur cluster binding
M036_13890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M036_13895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M036_13905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M036_13910	COG0124	histidyl-tRNA synthetase
M036_13920	COG4991	sh3 domain protein
M036_13920	COG3103	Sh3 type 3 domain protein
M036_13920	COG0860	N-Acetylmuramoyl-L-alanine amidase
M036_13925	COG1490	D-aminoacyl-tRNA deacylase activity
M036_13930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M036_13935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M036_13940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M036_13940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M036_13945	COG5416	Lipopolysaccharide assembly protein A domain
M036_13950	COG0490	domain, Protein
M036_13955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M036_13955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M036_13965	COG2244	polysaccharide biosynthetic process
M036_13970	COG2323	membrane
M036_13980	COG1862	Preprotein translocase
M036_13985	COG0343	queuine tRNA-ribosyltransferase activity
M036_13990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M036_14000	COG2255	four-way junction helicase activity
M036_14005	COG0632	four-way junction helicase activity
M036_14015	COG2814	Major facilitator Superfamily
M036_14020	COG0673	inositol 2-dehydrogenase activity
M036_14025	COG2112	serine threonine protein kinase
M036_14045	COG1115	amino acid carrier protein
M036_14050	COG0217	transcriptional regulatory protein
M036_14060	COG1388	LysM domain
M036_14065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M036_14070	COG0157	Belongs to the NadC ModD family
M036_14075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M036_14080	COG1104	cysteine desulfurase activity
M036_14085	COG1827	regulation of RNA biosynthetic process
M036_14090	COG0077	Prephenate dehydratase
M036_14095	COG4492	Belongs to the UPF0735 family
M036_14100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M036_14105	COG3290	protein histidine kinase activity
M036_14115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M036_14120	COG2868	ribosomal protein
M036_14125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M036_14130	COG1994	Peptidase M50
M036_14135	COG0739	heme binding
M036_14140	COG2894	cell division
M036_14145	COG0850	regulation of cytokinetic process
M036_14150	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M036_14155	COG1792	Involved in formation and maintenance of cell shape
M036_14160	COG1077	Cell shape determining protein MreB Mrl
M036_14165	COG2003	Belongs to the UPF0758 family
M036_14170	COG0424	maF-like protein
M036_14180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M036_14185	COG0285	dihydrofolate synthase activity
M036_14190	COG0525	valine-tRNA ligase activity
M036_14200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M036_14205	COG1388	LysM domain
M036_14210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M036_14215	COG0113	porphobilinogen synthase activity
M036_14220	COG1587	Uroporphyrinogen-III synthase
M036_14225	COG0181	hydroxymethylbilane synthase activity
M036_14230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M036_14235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M036_14245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M036_14250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M036_14255	COG0470	DNA polymerase III
M036_14255	COG1067	ATP-dependent peptidase activity
M036_14260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M036_14265	COG0544	peptidyl-prolyl cis-trans isomerase activity
M036_14270	COG1477	protein flavinylation
M036_14270	COG0457	Tetratricopeptide repeat
M036_14275	COG0066	3-isopropylmalate dehydratase activity
M036_14280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M036_14285	COG0473	3-isopropylmalate dehydrogenase activity
M036_14290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M036_14295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M036_14300	COG0440	acetolactate synthase activity
M036_14305	COG0028	Belongs to the TPP enzyme family
M036_14315	COG0454	-acetyltransferase
M036_14325	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
M036_14335	COG0622	Phosphoesterase
M036_14340	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M036_14345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M036_14350	COG5401	PFAM Sporulation and spore germination
M036_14355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M036_14360	COG1846	Transcriptional regulator
M036_14365	COG2197	response regulator
M036_14370	COG0824	Thioesterase
M036_14375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M036_14380	COG1053	succinate dehydrogenase
M036_14385	COG2009	succinate dehydrogenase
M036_14395	COG1719	4-vinyl reductase, 4VR
M036_14400	COG0527	aspartate kinase activity
M036_14405	COG0322	excinuclease ABC activity
M036_14410	COG3118	belongs to the thioredoxin family
M036_14415	COG3534	alpha-L-arabinofuranosidase
M036_14420	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M036_14425	COG2086	electron transfer activity
M036_14430	COG1024	Enoyl-CoA hydratase
M036_14435	COG1309	transcriptional regulator
M036_14440	COG0318	PFAM AMP-dependent synthetase and ligase
M036_14450	COG3766	membrane
M036_14455	COG1193	negative regulation of DNA recombination
M036_14460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M036_14460	COG1796	DNA polymerase
M036_14465	COG1286	toxin biosynthetic process
M036_14470	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M036_14475	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M036_14480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M036_14480	COG0072	phenylalanine-tRNA ligase activity
M036_14485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M036_14495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M036_14505	COG3835	regulator
M036_14510	COG0277	FAD linked oxidase domain protein
M036_14515	COG0247	lactate metabolic process
M036_14520	COG0346	lactoylglutathione lyase activity
M036_14525	COG1966	Carbon starvation protein
M036_14530	COG3534	alpha-L-arabinofuranosidase
M036_14535	COG0395	ABC-type sugar transport system, permease component
M036_14540	COG1175	transmembrane transport
M036_14545	COG1653	transport
M036_14550	COG0371	Dehydrogenase
M036_14555	COG0647	UMP catabolic process
M036_14560	COG0235	Class ii aldolase
M036_14565	COG1069	ribulokinase activity
M036_14570	COG2160	L-arabinose isomerase activity
M036_14575	COG3507	Belongs to the glycosyl hydrolase 43 family
M036_14580	COG1363	Peptidase, m42
M036_14590	COG3326	Membrane
M036_14595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M036_14600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M036_14605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M036_14615	COG1346	cytolysis
M036_14620	COG1380	Effector of murein hydrolase LrgA
M036_14625	COG3279	Response regulator of the LytR AlgR family
M036_14630	COG3275	phosphorelay sensor kinase activity
M036_14640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M036_14650	COG0398	Pfam SNARE associated Golgi protein
M036_14655	COG1484	DNA-dependent DNA replication
M036_14660	COG3611	Membrane attachment protein
M036_14665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M036_14670	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M036_14675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M036_14680	COG1733	regulation of RNA biosynthetic process
M036_14685	COG2814	Major facilitator Superfamily
M036_14690	COG0656	L-ascorbic acid biosynthetic process
M036_14695	COG0237	dephospho-CoA kinase activity
M036_14700	COG1971	Probably functions as a manganese efflux pump
M036_14705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M036_14710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M036_14710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M036_14715	COG5002	protein histidine kinase activity
M036_14720	COG0745	RESPONSE REGULATOR receiver
M036_14725	COG0039	L-malate dehydrogenase activity
M036_14730	COG0538	isocitrate dehydrogenase activity
M036_14735	COG0372	Belongs to the citrate synthase family
M036_14740	COG2707	UPF0756 membrane protein
M036_14745	COG0628	permease
M036_14750	COG3030	protein affecting phage T7 exclusion by the F plasmid
M036_14755	COG0469	pyruvate kinase activity
M036_14760	COG0205	6-phosphofructokinase activity
M036_14765	COG0825	malonyl-CoA metabolic process
M036_14770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M036_14775	COG0281	malic enzyme
M036_14780	COG0587	DNA-directed DNA polymerase activity
M036_14800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M036_14810	COG4109	DRTGG domain
M036_14820	COG0730	response to heat
M036_14825	COG1473	amidohydrolase
M036_14830	COG0196	riboflavin kinase activity
M036_14835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M036_14840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M036_14845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M036_14850	COG1126	abc transporter atp-binding protein
M036_14855	COG0765	amino acid transport
M036_14860	COG0765	amino acid transport
M036_14865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M036_14870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M036_14875	COG0454	-acetyltransferase
M036_14880	COG0583	DNA-binding transcription factor activity
M036_14885	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M036_14890	COG1028	Short-chain dehydrogenase reductase Sdr
M036_14900	COG0165	Argininosuccinate lyase
M036_14905	COG0137	argininosuccinate synthase activity
M036_14910	COG0521	Mo-molybdopterin cofactor biosynthetic process
M036_14915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M036_14920	COG0827	DNA restriction-modification system
M036_14925	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M036_14930	COG3874	Sporulation protein YtfJ
M036_14940	COG1714	RDD family
M036_14945	COG0616	signal peptide processing
M036_14950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M036_14955	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M036_14960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M036_14970	COG0301	tRNA thio-modification
M036_14975	COG1104	cysteine desulfurase activity
M036_14980	COG1114	Component of the transport system for branched-chain amino acids
M036_14985	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M036_14990	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M036_14995	COG1309	transcriptional regulator
M036_15000	COG1956	GAF domain-containing protein
M036_15005	COG2199	diguanylate cyclase activity
M036_15005	COG2203	Gaf domain
M036_15010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M036_15020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M036_15025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M036_15030	COG0454	-acetyltransferase
M036_15035	COG0517	IMP dehydrogenase activity
M036_15040	COG0123	including yeast histone deacetylase and acetoin utilization protein
M036_15045	COG1360	Flagellar Motor Protein
M036_15050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M036_15055	COG1609	Transcriptional regulator
M036_15060	COG1605	Chorismate mutase
M036_15060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M036_15065	COG3118	belongs to the thioredoxin family
M036_15070	COG4980	gas vesicle protein
M036_15075	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M036_15080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M036_15085	COG1674	ftsk spoiiie
M036_15090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M036_15095	COG4848	Belongs to the UPF0354 family
M036_15100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_15110	COG1363	Peptidase, m42
M036_15115	COG5584	Small secreted protein
M036_15120	COG0281	malic enzyme
M036_15125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M036_15130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M036_15140	COG0510	thiamine kinase activity
M036_15145	COG1523	belongs to the glycosyl hydrolase 13 family
M036_15150	COG1597	lipid kinase activity
M036_15160	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M036_15165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M036_15170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M036_15175	COG2252	PERMEase
M036_15180	COG4473	ABC transporter
M036_15185	COG1131	(ABC) transporter
M036_15190	COG1349	DNA-binding transcription factor activity
M036_15195	COG1187	pseudouridine synthase activity
M036_15205	COG2244	polysaccharide biosynthetic process
M036_15210	COG2081	HI0933 family
M036_15215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M036_15225	COG5578	integral membrane protein
M036_15230	COG0673	inositol 2-dehydrogenase activity
M036_15235	COG1653	transport
M036_15240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M036_15245	COG4209	transmembrane transport
M036_15250	COG2207	Transcriptional regulator
M036_15255	COG1653	transport
M036_15260	COG0395	ABC-type sugar transport system, permease component
M036_15265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M036_15270	COG2124	cytochrome p450
M036_15275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M036_15285	COG0156	8-amino-7-oxononanoate synthase activity
M036_15290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M036_15300	COG1073	alpha beta
M036_15325	COG1486	melibiose metabolic process
M036_15330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M036_15335	COG0495	leucyl-tRNA aminoacylation
M036_15345	COG2202	Pas domain
M036_15345	COG1366	Belongs to the anti-sigma-factor antagonist family
M036_15350	COG2814	Major facilitator Superfamily
M036_15355	COG2433	Pfam Transposase IS66
M036_15360	COG0577	efflux transmembrane transporter activity
M036_15365	COG1136	(ABC) transporter
M036_15370	COG2205	protein histidine kinase activity
M036_15375	COG0745	RESPONSE REGULATOR receiver
M036_15380	COG0577	efflux transmembrane transporter activity
M036_15385	COG1136	(ABC) transporter
M036_15400	COG1131	(ABC) transporter
M036_15405	COG1725	Transcriptional regulator
M036_15420	COG1242	4 iron, 4 sulfur cluster binding
M036_15425	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M036_15435	COG2267	carboxylic ester hydrolase activity
M036_15440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M036_15445	COG1113	amino acid transport
M036_15450	COG0367	asparagine synthase
M036_15455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M036_15460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M036_15470	COG1506	peptidase
M036_15475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M036_15480	COG1116	anion transmembrane transporter activity
M036_15485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M036_15490	COG0494	nUDIX hydrolase
M036_15495	COG4824	toxin secretion phage lysis holin
M036_15500	COG0783	Belongs to the Dps family
M036_15515	COG1854	S-ribosylhomocysteine lyase activity
M036_15520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M036_15525	COG0288	reversible hydration of carbon dioxide
M036_15530	COG0254	rRNA binding
M036_15535	COG1271	oxidase subunit
M036_15540	COG1294	oxidase, subunit
M036_15550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M036_15555	COG1321	iron dependent repressor
M036_15555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M036_15560	COG1121	(ABC) transporter
M036_15565	COG0803	Belongs to the bacterial solute-binding protein 9 family
M036_15570	COG4948	Mandelate Racemase Muconate Lactonizing
M036_15575	COG0318	PFAM AMP-dependent synthetase and ligase
M036_15580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M036_15585	COG0596	Alpha beta hydrolase
M036_15590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M036_15595	COG1169	isochorismate synthase
M036_15605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M036_15610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M036_15615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M036_15620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M036_15625	COG0438	transferase activity, transferring glycosyl groups
M036_15635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M036_15640	COG0438	transferase activity, transferring glycosyl groups
M036_15645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M036_15650	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M036_15655	COG0058	SHG alpha-glucan phosphorylase activity
M036_15660	COG0297	glycogen (starch) synthase activity
M036_15665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M036_15670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M036_15675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M036_15805	COG3859	Proton-coupled thiamine transporter YuaJ
M036_15810	COG1247	-acetyltransferase
M036_15815	COG2268	Band 7 protein
M036_15820	COG1585	Membrane protein implicated in regulation of membrane protease activity
M036_15825	COG2318	DinB family
M036_15835	COG1454	alcohol dehydrogenase
M036_15845	COG1510	regulation of RNA biosynthetic process
M036_15855	COG0569	domain protein
M036_15860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M036_15865	COG4682	membrane
M036_15870	COG1705	Flagellar rod assembly protein muramidase FlgJ
M036_15875	COG0477	Major facilitator Superfamily
M036_15880	COG5553	Cysteine dioxygenase type I
M036_15890	COG1968	undecaprenyl-diphosphatase activity
M036_15895	COG0628	permease
M036_15900	COG0673	inositol 2-dehydrogenase activity
M036_15905	COG4806	L-rhamnose isomerase
M036_15910	COG3254	rhamnose metabolic process
M036_15915	COG1070	Carbohydrate kinase
M036_15920	COG1349	DNA-binding transcription factor activity
M036_15925	COG1028	Short-chain dehydrogenase reductase Sdr
M036_15925	COG3347	Dehydrogenase
M036_15930	COG0840	transmembrane signaling receptor activity
M036_15935	COG0840	transmembrane signaling receptor activity
M036_15940	COG0840	transmembrane signaling receptor activity
M036_15945	COG0840	transmembrane signaling receptor activity
M036_15965	COG0432	Pfam Uncharacterised protein family UPF0047
M036_15970	COG0366	Alpha amylase catalytic
M036_15975	COG1253	flavin adenine dinucleotide binding
M036_15980	COG2738	Putative neutral zinc metallopeptidase
M036_15995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M036_16010	COG0166	Belongs to the GPI family
M036_16015	COG1979	alcohol dehydrogenase
M036_16020	COG1979	alcohol dehydrogenase
M036_16030	COG2155	Conserved Protein
M036_16035	COG1098	S1 RNA binding domain
M036_16040	COG0436	Aminotransferase
M036_16045	COG1522	sequence-specific DNA binding
M036_16050	COG2267	carboxylic ester hydrolase activity
M036_16060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M036_16065	COG2205	protein histidine kinase activity
M036_16075	COG5018	Exonuclease
M036_16085	COG2814	Major facilitator Superfamily
M036_16090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M036_16095	COG3011	Protein conserved in bacteria
M036_16105	COG3290	protein histidine kinase activity
M036_16110	COG4565	transcriptional regulatory protein
M036_16135	COG3493	citrate carrier protein
M036_16145	COG2111	Na H antiporter
M036_16145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M036_16150	COG2111	Na H antiporter
M036_16155	COG1006	Multisubunit Na H antiporter MnhC subunit
M036_16160	COG0651	ATP synthesis coupled electron transport
M036_16165	COG1863	multisubunit Na H antiporter MnhE subunit
M036_16170	COG2212	antiporter activity
M036_16175	COG1320	monovalent cation:proton antiporter activity
M036_16180	COG2050	protein possibly involved in aromatic compounds catabolism
M036_16185	COG2197	response regulator
M036_16200	COG0142	geranyltranstransferase activity
M036_16215	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M036_16220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M036_16225	COG1335	isochorismatase
M036_16230	COG5506	Protein of unknown function (DUF1694)
M036_16245	COG0628	permease
M036_16260	COG1418	mRNA catabolic process
M036_16265	COG1028	Short-chain dehydrogenase reductase Sdr
M036_16275	COG1511	domain protein
M036_16280	COG0433	COG0433 Predicted ATPase
M036_16280	COG1674	ftsk spoiiie
M036_16285	COG4499	WXG100 protein secretion system (Wss), protein YukC
M036_16290	COG5417	Belongs to the EsaB family
M036_16295	COG4842	Belongs to the WXG100 family
M036_16300	COG2508	Transcriptional regulator
M036_16300	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M036_16305	COG0686	Belongs to the AlaDH PNT family
M036_16310	COG5634	Uncharacterized conserved protein (DUF2278)
M036_16315	COG3251	PFAM MbtH domain protein
M036_16320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_16325	COG3433	isochorismatase activity
M036_16325	COG1535	isochorismatase
M036_16330	COG1021	2,3-dihydroxybenzoate-AMP ligase
M036_16335	COG1169	isochorismate synthase
M036_16340	COG1028	Short-chain dehydrogenase reductase Sdr
M036_16345	COG2819	hydrolase of the alpha beta superfamily
M036_16350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M036_16355	COG1268	BioY protein
M036_16360	COG2056	Na+-H+ antiporter family
M036_16365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M036_16370	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M036_16375	COG3584	3D domain protein
M036_16390	COG1252	NADH dehydrogenase
M036_16395	COG0492	ferredoxin-NADP+ reductase activity
M036_16405	COG0516	GMP reductase activity
M036_16410	COG2808	Putative FMN-binding domain
M036_16415	COG0456	acetyltransferase
M036_16420	COG0316	Belongs to the HesB IscA family
M036_16425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M036_16430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M036_16435	COG4844	belongs to the
M036_16440	COG1252	NADH dehydrogenase
M036_16445	COG4837	Protein of unknown function (DUF1462)
M036_16450	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M036_16455	COG0823	Involved in the tonB-independent uptake of proteins
M036_16455	COG1506	peptidase
M036_16455	COG4946	Tricorn protease homolog
M036_16460	COG0083	homoserine kinase activity
M036_16465	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M036_16470	COG0460	homoserine dehydrogenase
M036_16475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M036_16480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M036_16485	COG0647	UMP catabolic process
M036_16490	COG2445	Protein of unknown function DUF86
M036_16495	COG4470	Protein conserved in bacteria
M036_16505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M036_16510	COG0739	heme binding
M036_16520	COG3377	Domain of unknown function (DUF1805)
M036_16525	COG0737	Belongs to the 5'-nucleotidase family
M036_16530	COG0730	response to heat
M036_16535	COG1801	Protein of unknown function DUF72
M036_16545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M036_16550	COG2508	Transcriptional regulator
M036_16555	COG2233	PERMEase
M036_16560	COG2233	PERMEase
M036_16565	COG3195	allantoin biosynthetic process
M036_16565	COG3648	Uricase
M036_16570	COG2351	hydroxyisourate hydrolase activity
M036_16580	COG2080	2 iron, 2 sulfur cluster binding
M036_16585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M036_16590	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M036_16595	COG2068	MobA-Related Protein
M036_16600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M036_16605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M036_16610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M036_16615	COG2356	endonuclease I
M036_16620	COG3842	ATPase activity
M036_16625	COG2188	Transcriptional regulator
M036_16630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M036_16635	COG0395	ABC-type sugar transport system, permease component
M036_16640	COG1175	transmembrane transport
M036_16645	COG1653	transport
M036_16650	COG2222	sugar isomerase
M036_16655	COG0322	excinuclease ABC activity
M036_16660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M036_16675	COG0346	lactoylglutathione lyase activity
M036_16680	COG0640	Transcriptional regulator
M036_16685	COG0719	Fe-S assembly protein
M036_16690	COG0822	iron-sulfur transferase activity
M036_16695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M036_16700	COG0719	Fe-S assembly protein
M036_16705	COG0396	ATPase activity
M036_16715	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M036_16720	COG1464	Belongs to the NlpA lipoprotein family
M036_16725	COG2011	ABC-type metal ion transport system permease component
M036_16730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M036_16740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M036_16745	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M036_16755	COG0509	glycine decarboxylation via glycine cleavage system
M036_16760	COG1393	Belongs to the ArsC family
M036_16765	COG1960	acyl-CoA dehydrogenase activity
M036_16770	COG0183	Belongs to the thiolase family
M036_16775	COG1024	Enoyl-CoA hydratase
M036_16775	COG1250	3-hydroxyacyl-CoA dehydrogenase
M036_16785	COG0506	proline dehydrogenase activity
M036_16795	COG5577	PFAM Coat F domain
M036_16800	COG1846	Transcriptional regulator
M036_16805	COG0477	Major facilitator Superfamily
M036_16810	COG1942	4-Oxalocrotonate Tautomerase
M036_16820	COG0583	DNA-binding transcription factor activity
M036_16830	COG1120	ATPase activity
M036_16845	COG1028	Short-chain dehydrogenase reductase Sdr
M036_16850	COG0783	Belongs to the Dps family
M036_16855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M036_16865	COG0745	RESPONSE REGULATOR receiver
M036_16870	COG2770	Histidine kinase
M036_16870	COG2205	protein histidine kinase activity
M036_16880	COG1309	transcriptional regulator
M036_16885	COG0114	fumarate hydratase activity
M036_16895	COG0697	spore germination
M036_16900	COG0814	amino acid
M036_16910	COG2197	response regulator
M036_16915	COG4585	Histidine kinase
M036_16920	COG4758	membrane
M036_16925	COG3595	metallopeptidase activity
M036_16930	COG1842	Phage shock protein A
M036_16935	COG4758	membrane
M036_16940	COG2814	Major facilitator Superfamily
M036_16945	COG2096	Adenosyltransferase
M036_16950	COG1120	ATPase activity
M036_16955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_16960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M036_16965	COG1028	Short-chain dehydrogenase reductase Sdr
M036_16970	COG3386	PFAM SMP-30 Gluconolaconase
M036_16975	COG2205	protein histidine kinase activity
M036_16980	COG0745	RESPONSE REGULATOR receiver
M036_16990	COG1191	sigma factor activity
M036_17000	COG2140	Oxalate decarboxylase
M036_17010	COG0577	efflux transmembrane transporter activity
M036_17015	COG1136	(ABC) transporter
M036_17020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M036_17025	COG1120	ATPase activity
M036_17030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_17035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M036_17040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M036_17050	COG0531	amino acid
M036_17060	COG1988	membrane-bound metal-dependent
M036_17065	COG1368	sulfuric ester hydrolase activity
M036_17070	COG1910	domain protein
M036_17075	COG0725	ABC transporter, periplasmic molybdate-binding protein
M036_17080	COG4149	molybdate abc transporter
M036_17085	COG0656	L-ascorbic acid biosynthetic process
M036_17095	COG0025	NhaP-type Na H and K H
M036_17100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M036_17105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M036_17110	COG3973	AAA domain
M036_17115	COG2860	membrane
M036_17120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M036_17125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M036_17130	COG2217	Heavy metal translocating P-type atpase
M036_17135	COG2217	Heavy metal translocating P-type atpase
M036_17140	COG2608	mercury ion transmembrane transporter activity
M036_17145	COG1937	Protein conserved in bacteria
M036_17150	COG0673	inositol 2-dehydrogenase activity
M036_17155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M036_17160	COG1289	transmembrane transporter activity
M036_17170	COG2076	Multidrug Resistance protein
M036_17175	COG1309	transcriptional regulator
M036_17180	COG1028	Short-chain dehydrogenase reductase Sdr
M036_17185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M036_17190	COG0557	exoribonuclease II activity
M036_17195	COG1647	Serine aminopeptidase, S33
M036_17200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M036_17205	COG0596	Alpha beta hydrolase
M036_17210	COG1476	TRANSCRIPTIONal
M036_17215	COG1396	sequence-specific DNA binding
M036_17220	COG1396	sequence-specific DNA binding
M036_17225	COG1733	regulation of RNA biosynthetic process
M036_17230	COG0840	transmembrane signaling receptor activity
M036_17235	COG1174	glycine betaine transport
M036_17240	COG1732	Glycine betaine
M036_17245	COG1174	glycine betaine transport
M036_17250	COG1125	glycine betaine transport
M036_17250	COG0517	IMP dehydrogenase activity
M036_17255	COG1510	regulation of RNA biosynthetic process
M036_17275	COG5658	integral membrane protein
M036_17280	COG0640	Transcriptional regulator
M036_17285	COG1174	glycine betaine transport
M036_17290	COG1732	Glycine betaine
M036_17295	COG1174	glycine betaine transport
M036_17300	COG1125	glycine betaine transport
M036_17300	COG0517	IMP dehydrogenase activity
M036_17305	COG1510	regulation of RNA biosynthetic process
M036_17310	COG2095	MarC family integral membrane protein
M036_17320	COG3064	Membrane
M036_17325	COG4640	response to antibiotic
M036_17330	COG0456	acetyltransferase
M036_17335	COG0148	phosphopyruvate hydratase activity
M036_17340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M036_17345	COG0149	triose-phosphate isomerase activity
M036_17350	COG0126	phosphoglycerate kinase activity
M036_17360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M036_17365	COG2390	Transcriptional regulator
M036_17370	COG2814	Major facilitator Superfamily
M036_17375	COG1609	Transcriptional regulator
M036_17380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M036_17385	COG0583	DNA-binding transcription factor activity
M036_17390	COG0697	spore germination
M036_17395	COG1113	amino acid transport
M036_17400	COG3858	chitin binding
M036_17405	COG1556	Lactate utilization protein
M036_17410	COG1139	Iron-sulfur cluster binding protein
M036_17415	COG0247	lactate metabolic process
M036_17420	COG2197	response regulator
M036_17425	COG4585	Histidine kinase
M036_17430	COG0842	Transport permease protein
M036_17435	COG1131	(ABC) transporter
M036_17445	COG0596	Alpha beta hydrolase
M036_17450	COG2208	phosphoserine phosphatase activity
M036_17455	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M036_17460	COG1874	Beta-galactosidase
M036_17465	COG3833	ABC-type maltose transport systems, permease component
M036_17470	COG1175	transmembrane transport
M036_17475	COG2182	Extracellular solute-binding protein
M036_17480	COG1609	Transcriptional regulator
M036_17485	COG2186	Transcriptional regulator
M036_17490	COG1620	l-lactate permease
M036_17495	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M036_17505	COG5039	Polysaccharide pyruvyl transferase
M036_17510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M036_17515	COG0110	maltose O-acetyltransferase activity
M036_17520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M036_17525	COG2244	polysaccharide biosynthetic process
M036_17530	COG1216	Glycosyl transferase, family 2
M036_17535	COG5039	Polysaccharide pyruvyl transferase
M036_17540	COG1216	Glycosyl transferase, family 2
M036_17550	COG0438	transferase activity, transferring glycosyl groups
M036_17555	COG1215	transferase activity, transferring glycosyl groups
M036_17560	COG0438	transferase activity, transferring glycosyl groups
M036_17565	COG1086	Polysaccharide biosynthesis protein
M036_17570	COG0489	protein tyrosine kinase activity
M036_17575	COG3944	biosynthesis protein
M036_17580	COG1396	sequence-specific DNA binding
M036_17585	COG2272	Belongs to the type-B carboxylesterase lipase family
M036_17595	COG3479	Phenolic acid decarboxylase
M036_17605	COG1794	racemase activity, acting on amino acids and derivatives
M036_17610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M036_17615	COG1621	beta-fructofuranosidase activity
M036_17620	COG1621	beta-fructofuranosidase activity
M036_17625	COG0531	amino acid
M036_17630	COG1309	transcriptional regulator
M036_17635	COG2076	Multidrug Resistance protein
M036_17640	COG2076	Multidrug Resistance protein
M036_17650	COG0277	FAD linked oxidase domain protein
M036_17655	COG3621	Patatin-like phospholipase
M036_17665	COG0740	serine-type endopeptidase activity
M036_17670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M036_17675	COG0366	Alpha amylase catalytic
M036_17680	COG1554	hydrolase, family 65, central catalytic
M036_17685	COG5521	maltodextrose utilization protein MalA
M036_17690	COG3833	ABC-type maltose transport systems, permease component
M036_17695	COG1175	transmembrane transport
M036_17700	COG2182	Extracellular solute-binding protein
M036_17705	COG0366	Alpha amylase catalytic
M036_17710	COG1609	Transcriptional regulator
M036_17715	COG1611	Belongs to the LOG family
M036_17720	COG1694	Mazg nucleotide pyrophosphohydrolase
M036_17725	COG0659	secondary active sulfate transmembrane transporter activity
M036_17730	COG0288	reversible hydration of carbon dioxide
M036_17735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M036_17740	COG0577	efflux transmembrane transporter activity
M036_17745	COG1136	(ABC) transporter
M036_17750	COG5002	protein histidine kinase activity
M036_17755	COG0745	RESPONSE REGULATOR receiver
M036_17765	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M036_17770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M036_17775	COG1481	regulation of sporulation
M036_17780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M036_17785	COG1660	Displays ATPase and GTPase activities
M036_17790	COG1051	belongs to the nudix hydrolase family
M036_17795	COG0492	ferredoxin-NADP+ reductase activity
M036_17800	COG3883	PFAM NLP P60 protein
M036_17800	COG0791	NLP P60 protein
M036_17805	COG0457	Tetratricopeptide repeat
M036_17810	COG1132	(ABC) transporter
M036_17830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M036_17830	COG0140	phosphoribosyl-ATP diphosphatase activity
M036_17835	COG0107	imidazoleglycerol-phosphate synthase activity
M036_17840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M036_17845	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M036_17850	COG0131	Imidazoleglycerol-phosphate dehydratase
M036_17855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M036_17860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M036_17865	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M036_17870	COG4990	cell redox homeostasis
M036_17875	COG5297	Belongs to the glycosyl hydrolase family 6
M036_17880	COG0110	maltose O-acetyltransferase activity
M036_17885	COG0546	phosphoglycolate phosphatase activity
M036_17890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M036_17895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M036_17900	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M036_17905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M036_17910	COG0363	glucosamine-6-phosphate deaminase activity
M036_17920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M036_17925	COG1846	Transcriptional regulator
M036_17930	COG2124	cytochrome p450
M036_17940	COG1846	Transcriptional regulator
M036_17945	COG2814	Major facilitator Superfamily
M036_17950	COG1950	PFAM Membrane protein of
M036_17955	COG1983	PspC domain protein
M036_17960	COG3595	metallopeptidase activity
M036_17975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M036_17980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M036_17985	COG0556	nucleotide-excision repair
M036_17990	COG4897	Protein conserved in bacteria
M036_17995	COG3848	Pyruvate phosphate dikinase
M036_17995	COG0574	Belongs to the PEP-utilizing enzyme family
M036_18000	COG1309	transcriptional regulator
M036_18005	COG2814	Major facilitator Superfamily
M036_18010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M036_18020	COG0793	Belongs to the peptidase S41A family
M036_18020	COG3409	Peptidoglycan-binding domain 1 protein
M036_18025	COG2177	Part of the ABC transporter FtsEX involved in
M036_18030	COG2884	Cell division ATP-binding protein ftsE
M036_18035	COG2010	Cytochrome c
M036_18040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M036_18045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M036_18050	COG0653	protein targeting
M036_18055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M036_18070	COG1516	flagellar protein fliS
M036_18075	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M036_18080	COG1334	flagellar protein FlaG
M036_18085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M036_18090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M036_18095	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
M036_18105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M036_18110	COG1256	bacterial-type flagellum assembly
M036_18110	COG4786	Flagellar basal body rod
M036_18115	COG3418	PFAM FlgN family protein
M036_18120	COG2747	anti-sigma28 factor FlgM
M036_18130	COG1040	competence protein
M036_18140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M036_18145	COG1307	EDD domain protein, DegV family
M036_18150	COG2197	response regulator
M036_18155	COG4585	Histidine kinase
M036_18160	COG1739	Uncharacterized protein family UPF0029
M036_18165	COG1316	TRANSCRIPTIONal
M036_18170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M036_18175	COG0438	transferase activity, transferring glycosyl groups
M036_18180	COG1215	transferase activity, transferring glycosyl groups
M036_18185	COG3206	protein involved in exopolysaccharide biosynthesis
M036_18190	COG3307	-O-antigen
M036_18195	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M036_18200	COG0297	glycogen (starch) synthase activity
M036_18200	COG0438	transferase activity, transferring glycosyl groups
M036_18205	COG2244	polysaccharide biosynthetic process
M036_18215	COG2247	cell wall binding repeat
M036_18215	COG0860	N-Acetylmuramoyl-L-alanine amidase
M036_18220	COG2247	cell wall binding repeat
M036_18220	COG2385	sporulation resulting in formation of a cellular spore
M036_18230	COG1316	TRANSCRIPTIONal
M036_18235	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M036_18240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M036_18245	COG1215	transferase activity, transferring glycosyl groups
M036_18245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M036_18250	COG0463	Glycosyl transferase, family 2
M036_18255	COG1134	teichoic acid transport
M036_18260	COG1682	transport, permease protein
M036_18265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M036_18270	COG0438	transferase activity, transferring glycosyl groups
M036_18275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M036_18280	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M036_18285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M036_18295	COG4193	domain, Protein
M036_18300	COG1482	cell wall glycoprotein biosynthetic process
M036_18310	COG0697	spore germination
M036_18315	COG0814	amino acid
M036_18325	COG2814	Major facilitator Superfamily
M036_18330	COG1316	TRANSCRIPTIONal
M036_18335	COG0561	phosphatase activity
M036_18340	COG0791	NLP P60 protein
M036_18350	COG2843	Capsule synthesis protein
M036_18360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M036_18365	COG1609	Transcriptional regulator
M036_18370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M036_18375	COG1869	D-ribose catabolic process
M036_18380	COG1129	ABC transporter
M036_18385	COG1172	Belongs to the binding-protein-dependent transport system permease family
M036_18390	COG1879	ABC-type sugar transport system periplasmic component
M036_18395	COG3103	Sh3 type 3 domain protein
M036_18405	COG2249	NAD(P)H dehydrogenase (quinone) activity
M036_18410	COG3527	Alpha-acetolactate decarboxylase
M036_18415	COG0028	Belongs to the TPP enzyme family
M036_18420	COG0583	DNA-binding transcription factor activity
M036_18425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M036_18440	COG5337	Spore coat protein CotH
M036_18450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M036_18460	COG0405	Gamma-glutamyltransferase
M036_18465	COG1522	sequence-specific DNA binding
M036_18470	COG2059	Chromate
M036_18475	COG2059	Chromate
M036_18485	COG0655	NAD(P)H dehydrogenase (quinone) activity
M036_18490	COG0583	DNA-binding transcription factor activity
M036_18505	COG5444	nuclease activity
M036_18520	COG3878	Protein conserved in bacteria
M036_18525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M036_18530	COG4464	protein tyrosine phosphatase activity
M036_18535	COG0489	protein tyrosine kinase activity
M036_18540	COG3944	biosynthesis protein
M036_18550	COG4715	Zinc finger, swim domain protein
M036_18555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M036_18560	COG0561	phosphatase activity
M036_18565	COG1349	DNA-binding transcription factor activity
M036_18570	COG0629	single-stranded DNA binding
M036_18585	COG3764	Sortase (surface protein transpeptidase)
M036_18595	COG2972	Histidine kinase
M036_18595	COG0745	RESPONSE REGULATOR receiver
M036_18600	COG1970	mechanosensitive ion channel activity
M036_18605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M036_18610	COG0457	Tetratricopeptide repeat
M036_18615	COG4786	Flagellar basal body rod
M036_18620	COG4786	Flagellar basal body rod
M036_18625	COG1077	Cell shape determining protein MreB Mrl
M036_18630	COG1609	Transcriptional regulator
M036_18635	COG1846	Transcriptional regulator
M036_18640	COG2814	Major facilitator Superfamily
M036_18645	COG3420	alginic acid biosynthetic process
M036_18650	COG1953	Uracil, thiamine, allantoin
M036_18655	COG0477	Major facilitator Superfamily
M036_18660	COG1335	isochorismatase
M036_18670	COG0004	ammonium transporteR
M036_18675	COG0347	Belongs to the P(II) protein family
M036_18680	COG0671	phosphoesterase, PA-phosphatase related
M036_18690	COG0739	heme binding
M036_18695	COG1247	-acetyltransferase
M036_18715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M036_18720	COG0789	Transcriptional regulator
M036_18730	COG2910	NAD(P)H-binding
M036_18735	COG1959	2 iron, 2 sulfur cluster binding
M036_18740	COG0804	urea catabolic process
M036_18745	COG0832	Belongs to the urease beta subunit family
M036_18750	COG0831	urea catabolic process
M036_18755	COG3237	CsbD-like
M036_18760	COG1994	Peptidase M50
M036_18765	COG0457	Tetratricopeptide repeat
M036_18770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M036_18775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M036_18785	COG2304	oxidoreductase activity
M036_18795	COG2304	oxidoreductase activity
M036_18800	COG2385	sporulation resulting in formation of a cellular spore
M036_18805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M036_18815	COG4836	Membrane
M036_18825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M036_18830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M036_18835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M036_18840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M036_18845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M036_18850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M036_18860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M036_18865	COG0356	it plays a direct role in the translocation of protons across the membrane
M036_18875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M036_18880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M036_18885	COG4475	Protein of unknown function (DUF436)
M036_18890	COG0698	ribose 5-phosphate isomerase
M036_18895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M036_18900	COG1971	Probably functions as a manganese efflux pump
M036_18905	COG0009	L-threonylcarbamoyladenylate synthase
M036_18910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M036_18930	COG2890	protein-(glutamine-N5) methyltransferase activity
M036_18935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M036_18940	COG0346	lactoylglutathione lyase activity
M036_18945	COG0789	Transcriptional regulator
M036_18950	COG0679	Auxin Efflux Carrier
M036_18955	COG0281	malic enzyme
M036_18960	COG1435	thymidine kinase activity
M036_18965	COG0254	rRNA binding
M036_18970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M036_18975	COG1494	fructose-1,6-bisphosphatase
M036_18980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M036_18985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M036_18990	COG0191	fructose-bisphosphate aldolase activity
M036_18995	COG2204	response regulator
M036_19000	COG4821	SIS domain
M036_19005	COG0504	CTP synthase activity
M036_19010	COG3343	RNA polymerase activity
M036_19015	COG1960	acyl-CoA dehydrogenase activity
M036_19020	COG0247	lactate metabolic process
M036_19020	COG2181	nitrate reductase activity
M036_19025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M036_19030	COG4294	response to UV
M036_19045	COG1132	(ABC) transporter
M036_19050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M036_19060	COG2181	nitrate reductase activity
M036_19065	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M036_19070	COG1140	nitrate reductase beta subunit
M036_19075	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M036_19080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M036_19090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M036_19095	COG2223	nitrite transmembrane transporter activity
M036_19100	COG0018	arginyl-trna synthetase
M036_19105	COG4506	Protein conserved in bacteria
M036_19115	COG0535	radical SAM domain protein
M036_19125	COG1131	(ABC) transporter
M036_19130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M036_19135	COG0612	Peptidase, M16
M036_19140	COG0612	Peptidase, M16
M036_19150	COG3391	amine dehydrogenase activity
M036_19155	COG3391	amine dehydrogenase activity
M036_19165	COG0457	Tetratricopeptide repeat
M036_19175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M036_19180	COG0010	Belongs to the arginase family
M036_19185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M036_19190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M036_19200	COG1994	Peptidase M50
M036_19205	COG1942	4-Oxalocrotonate Tautomerase
M036_19210	COG1846	Transcriptional regulator
M036_19215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M036_19230	COG0477	Major facilitator Superfamily
M036_19235	COG1959	2 iron, 2 sulfur cluster binding
M036_19240	COG3465	dGTPase activity
M036_19245	COG1078	dGTPase activity
M036_19250	COG4844	belongs to the
M036_19260	COG0697	spore germination
M036_19265	COG0095	Lipoate-protein ligase
M036_19270	COG0583	DNA-binding transcription factor activity
M036_19275	COG0280	phosphate acetyltransferase
M036_19285	COG1028	Short-chain dehydrogenase reductase Sdr
M036_19290	COG0436	Aminotransferase
M036_19295	COG2814	Major facilitator Superfamily
M036_19300	COG0151	Belongs to the GarS family
M036_19305	COG1028	Short-chain dehydrogenase reductase Sdr
M036_19310	COG1917	Cupin 2, conserved barrel domain protein
M036_19315	COG0077	Prephenate dehydratase
M036_19320	COG2814	Major facilitator Superfamily
M036_19325	COG0833	amino acid
M036_19330	COG4187	Peptidase family M20/M25/M40
M036_19335	COG1012	belongs to the aldehyde dehydrogenase family
M036_19340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M036_19350	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M036_19355	COG1091	dTDP-4-dehydrorhamnose reductase activity
M036_19360	COG1088	dTDP-glucose 4,6-dehydratase activity
M036_19365	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M036_19370	COG3980	spore coat polysaccharide biosynthesis protein
M036_19375	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M036_19380	COG2089	acid synthase
M036_19385	COG0456	acetyltransferase
M036_19390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M036_19395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M036_19400	COG0463	Glycosyl transferase, family 2
M036_19415	COG2363	Small membrane protein
M036_19420	COG2233	PERMEase
M036_19430	COG1012	belongs to the aldehyde dehydrogenase family
M036_19435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M036_19440	COG1216	Glycosyl transferase, family 2
M036_19455	COG1695	Transcriptional regulator
M036_19460	COG0351	phosphomethylpyrimidine kinase
M036_19470	COG1621	beta-fructofuranosidase activity
M036_19475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_19475	COG1263	PTS System
M036_19480	COG2116	formate transmembrane transporter activity
M036_19485	COG3711	transcriptional antiterminator
M036_19495	COG1404	Belongs to the peptidase S8 family
M036_19500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M036_19505	COG0778	Nitroreductase
M036_19510	COG0772	Belongs to the SEDS family
M036_19520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M036_19525	COG1845	cytochrome c oxidase, subunit III
M036_19530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M036_19535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M036_19545	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M036_19550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M036_19555	COG2246	polysaccharide biosynthetic process
M036_19560	COG1309	transcriptional regulator
M036_19570	COG3162	membrane
M036_19575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M036_19580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M036_19585	COG2837	iron assimilation
M036_19590	COG2822	iron ion transport
M036_19595	COG0672	)-iron permease
M036_19600	COG0352	thiamine-phosphate diphosphorylase activity
M036_19605	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M036_19610	COG0583	DNA-binding transcription factor activity
M036_19615	COG1380	Effector of murein hydrolase LrgA
M036_19620	COG1346	cytolysis
M036_19625	COG2814	Major facilitator Superfamily
M036_19630	COG4895	conserved protein (DUF2196)
M036_19635	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M036_19640	COG0346	lactoylglutathione lyase activity
M036_19655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M036_19660	COG1404	Belongs to the peptidase S8 family
M036_19665	COG1263	PTS System
M036_19665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_19670	COG3711	transcriptional antiterminator
M036_19675	COG1442	glycosyl transferase family 8
M036_19680	COG5522	Integral membrane protein (intg_mem_TP0381)
M036_19685	COG1846	Transcriptional regulator
M036_19690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M036_19695	COG2234	aminopeptidase activity
M036_19700	COG2357	RelA SpoT domain protein
M036_19705	COG1575	Belongs to the MenA family. Type 1 subfamily
M036_19720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M036_19725	COG1696	Membrane protein involved in D-alanine export
M036_19730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M036_19735	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M036_19740	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M036_19745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M036_19750	COG1486	melibiose metabolic process
M036_19755	COG1447	Phosphotransferase system cellobiose-specific component IIA
M036_19760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M036_19765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M036_19770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M036_19770	COG3711	transcriptional antiterminator
M036_19780	COG2094	Belongs to the DNA glycosylase MPG family
M036_19785	COG0753	catalase activity
M036_19790	COG2814	Major facilitator Superfamily
M036_19795	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M036_19800	COG1131	(ABC) transporter
M036_19820	COG1595	DNA-templated transcription, initiation
M036_19825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M036_19830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M036_19835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M036_19840	COG4988	ABC transporter
M036_19845	COG1294	oxidase, subunit
M036_19850	COG1271	oxidase subunit
M036_19855	COG3493	citrate carrier protein
M036_19860	COG0501	Belongs to the peptidase M48B family
M036_19870	COG0726	polysaccharide deacetylase
M036_19875	COG3842	ATPase activity
M036_19880	COG2508	Transcriptional regulator
M036_19885	COG1012	belongs to the aldehyde dehydrogenase family
M036_19890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M036_19900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M036_19910	COG4585	Histidine kinase
M036_19915	COG2197	response regulator
M036_19920	COG2195	Cleaves the N-terminal amino acid of tripeptides
M036_19935	COG4894	glucomannan catabolic process
M036_19940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M036_19945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M036_19950	COG1028	Short-chain dehydrogenase reductase Sdr
M036_19955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M036_19960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M036_19965	COG2610	gluconate transmembrane transporter activity
M036_19975	COG0500	methyltransferase
M036_19980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M036_19995	COG0693	protein deglycase activity
M036_19995	COG0753	catalase activity
M036_20000	COG2851	Citrate transporter
M036_20005	COG2273	Hydrolase Family 16
M036_20010	COG3711	transcriptional antiterminator
M036_20020	COG2270	Major facilitator Superfamily
M036_20025	COG0513	Belongs to the DEAD box helicase family
M036_20030	COG3401	FG-GAP repeat protein
M036_20030	COG2755	lipolytic protein G-D-S-L family
M036_20085	COG3209	COG3209 Rhs family protein
M036_20090	COG0697	spore germination
M036_20095	COG0589	response to stress
M036_20100	COG2723	6-phospho-beta-galactosidase activity
M036_20105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M036_20105	COG2190	(PTS) system
M036_20105	COG1263	PTS System
M036_20120	COG5444	nuclease activity
M036_20135	COG3507	Belongs to the glycosyl hydrolase 43 family
M036_20145	COG2986	histidine ammonia-lyase
M036_20150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M036_20155	COG1228	amidohydrolase
M036_20160	COG0010	Belongs to the arginase family
M036_20165	COG0833	amino acid
M036_20170	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M036_20175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M036_20180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M036_20185	COG2390	Transcriptional regulator
M036_20195	COG3192	ethanolamine utilization protein
M036_20200	COG2079	MmgE PrpD family protein
M036_20210	COG1126	abc transporter atp-binding protein
M036_20215	COG0765	amino acid transport
M036_20220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M036_20240	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M036_20245	COG0561	phosphatase activity
M036_20275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M036_20280	COG5294	Protein conserved in bacteria
M036_20285	COG0577	efflux transmembrane transporter activity
M036_20290	COG1136	(ABC) transporter
M036_20295	COG2205	protein histidine kinase activity
M036_20300	COG0745	RESPONSE REGULATOR receiver
M036_20305	COG0191	fructose-bisphosphate aldolase activity
M036_20310	COG1082	Xylose isomerase domain protein TIM barrel
M036_20315	COG1082	Xylose isomerase domain protein TIM barrel
M036_20320	COG0673	inositol 2-dehydrogenase activity
M036_20325	COG2814	Major facilitator Superfamily
M036_20330	COG1082	Xylose isomerase domain protein TIM barrel
M036_20335	COG3962	Belongs to the TPP enzyme family
M036_20340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M036_20345	COG3718	enzyme involved in inositol metabolism
M036_20350	COG1012	belongs to the aldehyde dehydrogenase family
M036_20355	COG1349	DNA-binding transcription factor activity
M036_20360	COG0667	Aldo Keto reductase
M036_20375	COG2814	Major facilitator Superfamily
M036_20380	COG0326	Molecular chaperone. Has ATPase activity
M036_20390	COG1028	Short-chain dehydrogenase reductase Sdr
M036_20395	COG1309	transcriptional regulator
M036_20400	COG1012	belongs to the aldehyde dehydrogenase family
M036_20405	COG0456	acetyltransferase
M036_20410	COG2850	peptidyl-arginine hydroxylation
M036_20415	COG2226	methyltransferase
M036_20430	COG0367	asparagine synthase
M036_20435	COG2814	Major facilitator Superfamily
M036_20440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M036_20450	COG1714	RDD family
M036_20455	COG2311	Membrane
M036_20460	COG1917	Cupin 2, conserved barrel domain protein
M036_20465	COG1309	transcriptional regulator
M036_20470	COG1028	Short-chain dehydrogenase reductase Sdr
M036_20475	COG1846	Transcriptional regulator
M036_20480	COG1380	Effector of murein hydrolase LrgA
M036_20485	COG1346	cytolysis
M036_20490	COG5039	Polysaccharide pyruvyl transferase
M036_20495	COG1929	Belongs to the glycerate kinase type-1 family
M036_20500	COG1802	Transcriptional regulator
M036_20505	COG1070	Carbohydrate kinase
M036_20510	COG2610	gluconate transmembrane transporter activity
M036_20515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M036_20520	COG0450	alkyl hydroperoxide reductase
M036_20525	COG3634	alkyl hydroperoxide reductase activity
M036_20530	COG2723	6-phospho-beta-galactosidase activity
M036_20535	COG2190	(PTS) system
M036_20540	COG2188	Transcriptional regulator
M036_20555	COG1131	(ABC) transporter
M036_20560	COG1994	Peptidase M50
M036_20565	COG0535	radical SAM domain protein
M036_20575	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
M036_20580	COG5293	efflux transmembrane transporter activity
M036_20590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M036_20595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M036_20610	COG1063	alcohol dehydrogenase
M036_20630	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M036_20635	COG0456	acetyltransferase
M036_20640	COG0457	Tetratricopeptide repeat
M036_20650	COG0010	Belongs to the arginase family
M036_20655	COG0833	amino acid
M036_20660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M036_20665	COG3829	transcription factor binding
M036_20670	COG5002	protein histidine kinase activity
M036_20690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M036_20695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M036_20700	COG4853	Protein conserved in bacteria
M036_20705	COG4863	YycH protein
M036_20710	COG5002	protein histidine kinase activity
M036_20715	COG0745	RESPONSE REGULATOR receiver
M036_20745	COG0346	lactoylglutathione lyase activity
M036_20750	COG0305	Participates in initiation and elongation during chromosome replication
M036_20770	COG3093	addiction module antidote protein HigA
M036_20775	COG2807	transmembrane transport
M036_20780	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M036_20785	COG0359	binds to the 23S rRNA
M036_20790	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M036_20795	COG4241	membrane
M036_20805	COG5577	PFAM Coat F domain
M036_20810	COG1733	regulation of RNA biosynthetic process
M036_20815	COG1227	inorganic diphosphatase activity
M036_20830	COG2271	Major facilitator Superfamily
M036_20835	COG0789	Transcriptional regulator
M036_20835	COG4978	Transcriptional regulator
M036_20845	COG4319	ketosteroid isomerase
M036_20850	COG1357	PFAM Pentapeptide repeats (8 copies)
M036_20855	COG2814	Major facilitator Superfamily
M036_20860	COG0583	DNA-binding transcription factor activity
M036_20865	COG2153	protein acetylation
M036_20875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M036_20880	COG1846	Transcriptional regulator
M036_20885	COG2153	protein acetylation
M036_20890	COG2364	Membrane
M036_20895	COG0456	acetyltransferase
M036_20900	COG2315	Protein conserved in bacteria
M036_20905	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M036_20910	COG2814	Major facilitator Superfamily
M036_20915	COG1331	Highly conserved protein containing a thioredoxin domain
M036_20920	COG1266	CAAX protease self-immunity
M036_20925	COG2814	Major facilitator Superfamily
M036_20925	COG0477	Major facilitator Superfamily
M036_20930	COG0110	maltose O-acetyltransferase activity
M036_20935	COG0346	lactoylglutathione lyase activity
M036_20940	COG1609	Transcriptional regulator
M036_20945	COG0708	Exodeoxyribonuclease III
M036_20950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M036_20955	COG0629	single-stranded DNA binding
M036_20960	COG0360	Binds together with S18 to 16S ribosomal RNA
M036_20965	COG0012	GTP binding
M036_20970	COG0243	molybdopterin cofactor binding
M036_20975	COG4481	Protein conserved in bacteria
M036_20980	COG3949	Membrane
M036_20990	COG1475	DNA binding
M036_20995	COG1192	Involved in chromosome partitioning
M036_21010	COG1475	DNA binding
M036_21015	COG0357	Ribosomal RNA small subunit methyltransferase G
M036_21020	COG0445	tRNA wobble uridine modification
M036_21025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M036_21030	COG1847	R3H domain protein
M036_21035	COG0706	membrane insertase activity
M036_21040	COG0594	ribonuclease P activity
M036_21045	COG0230	Belongs to the bacterial ribosomal protein bL34 family