locus-tag	class	description
GO005_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GO005_00010	COG0592	DNA-directed DNA polymerase activity
GO005_00015	COG2501	S4 domain
GO005_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GO005_00030	COG0187	DNA topoisomerase II activity
GO005_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO005_00070	COG0517	IMP dehydrogenase activity
GO005_00070	COG0516	GMP reductase activity
GO005_00075	COG1686	Belongs to the peptidase S11 family
GO005_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GO005_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GO005_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GO005_00100	COG1428	Deoxynucleoside kinase
GO005_00105	COG1428	Deoxynucleoside kinase
GO005_00110	COG3858	chitin binding
GO005_00110	COG1388	LysM domain
GO005_00115	COG1335	isochorismatase
GO005_00120	COG0590	tRNA wobble adenosine to inosine editing
GO005_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GO005_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GO005_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO005_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GO005_00190	COG3853	Toxic anion resistance protein (TelA)
GO005_00195	COG1982	Orn Lys Arg decarboxylase major
GO005_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO005_00205	COG3870	Protein conserved in bacteria
GO005_00210	COG1728	Protein conserved in bacteria
GO005_00215	COG0470	DNA polymerase III
GO005_00220	COG1774	PSP1 C-terminal conserved region
GO005_00225	COG4467	Involved in initiation control of chromosome replication
GO005_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GO005_00235	COG2827	Endonuclease containing a URI domain
GO005_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GO005_00245	COG2002	toxin-antitoxin pair type II binding
GO005_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO005_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO005_00255	COG0084	hydrolase, TatD family'
GO005_00260	COG3584	3D domain protein
GO005_00260	COG3583	domain protein
GO005_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GO005_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GO005_00280	COG4466	Protein conserved in bacteria
GO005_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GO005_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO005_00300	COG0251	oxidation-reduction process
GO005_00305	COG2088	sporulation resulting in formation of a cellular spore
GO005_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GO005_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO005_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GO005_00325	COG0193	aminoacyl-tRNA hydrolase activity
GO005_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GO005_00340	COG2002	toxin-antitoxin pair type II binding
GO005_00345	COG2244	polysaccharide biosynthetic process
GO005_00350	COG3956	TIGRFAM MazG family protein
GO005_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GO005_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GO005_00375	COG1098	S1 RNA binding domain
GO005_00390	COG2208	phosphoserine phosphatase activity
GO005_00395	COG2304	oxidoreductase activity
GO005_00400	COG0515	serine threonine protein kinase
GO005_00405	COG0037	tRNA processing
GO005_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GO005_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO005_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GO005_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GO005_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO005_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO005_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO005_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
GO005_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO005_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO005_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GO005_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO005_00470	COG1396	sequence-specific DNA binding
GO005_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO005_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GO005_00560	COG4463	regulation of RNA biosynthetic process
GO005_00565	COG3880	PFAM UvrB UvrC protein
GO005_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GO005_00575	COG0542	response to heat
GO005_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GO005_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GO005_00590	COG4956	integral membrane protein (PIN domain superfamily)
GO005_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO005_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO005_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO005_00610	COG1045	serine acetyltransferase
GO005_00615	COG0215	cysteine-tRNA ligase activity
GO005_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GO005_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO005_00630	COG3688	RNA-binding protein containing a PIN domain
GO005_00635	COG1595	DNA-templated transcription, initiation
GO005_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO005_00650	COG0250	Participates in transcription elongation, termination and antitermination
GO005_00660	COG0081	regulation of translation
GO005_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GO005_00675	COG2813	Specifically methylates the guanine in position
GO005_00680	COG0085	RNA polymerase activity
GO005_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GO005_00690	COG1358	cellular component organization or biogenesis
GO005_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GO005_00700	COG0049	tRNA binding
GO005_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO005_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GO005_00715	COG0596	Alpha beta hydrolase
GO005_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GO005_00730	COG0088	Forms part of the polypeptide exit tunnel
GO005_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GO005_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GO005_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GO005_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GO005_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GO005_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GO005_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GO005_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GO005_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GO005_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GO005_00820	COG0200	Binds to the 23S rRNA
GO005_00825	COG0201	protein transport
GO005_00830	COG0563	adenylate kinase activity
GO005_00835	COG0024	Methionine aminopeptidase
GO005_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GO005_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO005_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GO005_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GO005_00865	COG0202	RNA polymerase activity
GO005_00870	COG0203	ribosomal protein L17
GO005_00875	COG1122	ATPase activity
GO005_00880	COG1122	ATPase activity
GO005_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GO005_00890	COG0101	tRNA pseudouridine synthase activity
GO005_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GO005_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO005_00905	COG2226	methyltransferase
GO005_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO005_00920	COG0489	protein tyrosine kinase activity
GO005_00930	COG2194	sulfuric ester hydrolase activity
GO005_00935	COG0726	polysaccharide deacetylase
GO005_00970	COG2856	Zn peptidase
GO005_00980	COG1395	domain, Protein
GO005_01040	COG0305	Participates in initiation and elongation during chromosome replication
GO005_01050	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GO005_01125	COG1783	phage Terminase large subunit
GO005_01130	COG5518	Phage portal protein
GO005_01135	COG2369	cell adhesion
GO005_01145	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO005_01150	COG4653	Phage capsid family
GO005_01200	COG5280	Phage tail tape measure protein TP901
GO005_01200	COG3953	SLT domain
GO005_01205	COG1652	LysM domain
GO005_01210	COG4193	domain, Protein
GO005_01220	COG3628	GPW Gp25 family protein
GO005_01225	COG3299	homolog of phage Mu protein gp47
GO005_01230	COG3778	Protein conserved in bacteria
GO005_01270	COG1388	LysM domain
GO005_01270	COG3409	Peptidoglycan-binding domain 1 protein
GO005_01270	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO005_01280	COG5444	nuclease activity
GO005_01285	COG0457	Tetratricopeptide repeat
GO005_01300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO005_01360	COG0659	secondary active sulfate transmembrane transporter activity
GO005_01365	COG0385	Bile acid
GO005_01370	COG2819	hydrolase of the alpha beta superfamily
GO005_01375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_01380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_01385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO005_01390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO005_01390	COG2207	Transcriptional regulator
GO005_01395	COG3876	Protein conserved in bacteria
GO005_01400	COG1472	Belongs to the glycosyl hydrolase 3 family
GO005_01405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO005_01410	COG1263	PTS System
GO005_01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_01415	COG1737	Transcriptional regulator
GO005_01420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GO005_01425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO005_01430	COG1683	Conserved Protein
GO005_01460	COG1595	DNA-templated transcription, initiation
GO005_01465	COG5662	AntiSigma factor
GO005_01470	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GO005_01475	COG4856	YbbR-like protein
GO005_01480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO005_01485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO005_01495	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO005_01500	COG2169	Transcriptional regulator
GO005_01505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO005_01510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO005_01515	COG3002	Belongs to the UPF0753 family
GO005_01520	COG0288	reversible hydration of carbon dioxide
GO005_01530	COG5609	conserved protein (DUF2294)
GO005_01535	COG0640	Transcriptional regulator
GO005_01540	COG2814	Major facilitator Superfamily
GO005_01545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO005_01555	COG0535	radical SAM domain protein
GO005_01560	COG1266	CAAX protease self-immunity
GO005_01565	COG1131	(ABC) transporter
GO005_01575	COG1413	lyase activity
GO005_01580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_01590	COG0745	RESPONSE REGULATOR receiver
GO005_01595	COG0642	Histidine kinase
GO005_01605	COG0515	serine threonine protein kinase
GO005_01620	COG1113	amino acid transport
GO005_01635	COG2602	Beta-lactamase
GO005_01640	COG2124	cytochrome p450
GO005_01650	COG0531	amino acid
GO005_01655	COG0584	glycerophosphoryl diester phosphodiesterase
GO005_01660	COG2271	Major facilitator Superfamily
GO005_01670	COG1846	Transcriptional regulator
GO005_01670	COG0456	acetyltransferase
GO005_01675	COG2271	Major facilitator Superfamily
GO005_01690	COG3409	Peptidoglycan-binding domain 1 protein
GO005_01695	COG0697	spore germination
GO005_01700	COG1917	Cupin 2, conserved barrel domain protein
GO005_01700	COG2207	Transcriptional regulator
GO005_01705	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GO005_01710	COG3591	Belongs to the peptidase S1B family
GO005_01720	COG0596	Alpha beta hydrolase
GO005_01725	COG1183	phosphatidylcholine synthase activity
GO005_01730	COG0586	Pfam SNARE associated Golgi protein
GO005_01735	COG0688	phosphatidylethanolamine metabolic process
GO005_01745	COG2312	Erythromycin esterase
GO005_01750	COG2207	Transcriptional regulator
GO005_01755	COG1054	Belongs to the UPF0176 family
GO005_01760	COG1301	dicarboxylic acid transport
GO005_01765	COG2190	(PTS) system
GO005_01765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_01765	COG1263	PTS System
GO005_01770	COG0363	glucosamine-6-phosphate deaminase activity
GO005_01775	COG2188	Transcriptional regulator
GO005_01785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO005_01790	COG0833	amino acid
GO005_01795	COG2040	homocysteine
GO005_01805	COG1115	amino acid carrier protein
GO005_01810	COG2066	Belongs to the glutaminase family
GO005_01815	COG4191	Histidine kinase
GO005_01820	COG0784	Response regulator, receiver
GO005_01825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO005_01830	COG1012	belongs to the aldehyde dehydrogenase family
GO005_01835	COG2271	Major facilitator Superfamily
GO005_01840	COG4948	Mandelate Racemase Muconate Lactonizing
GO005_01845	COG2186	Transcriptional regulator
GO005_01850	COG2721	sulfolactate sulfo-lyase activity
GO005_01855	COG3173	Aminoglycoside phosphotransferase
GO005_01865	COG0697	spore germination
GO005_01870	COG0745	RESPONSE REGULATOR receiver
GO005_01875	COG2205	protein histidine kinase activity
GO005_01880	COG1131	(ABC) transporter
GO005_01900	COG3773	Cell wall hydrolase
GO005_01905	COG2304	oxidoreductase activity
GO005_01915	COG3540	Alkaline phosphatase
GO005_01920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO005_01925	COG0805	protein transport
GO005_01930	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GO005_01935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO005_01940	COG0477	Major facilitator Superfamily
GO005_01945	COG1309	transcriptional regulator
GO005_01950	COG0252	asparaginase activity
GO005_01955	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO005_01960	COG1714	RDD family
GO005_01965	COG1405	negative regulation of cell septum assembly
GO005_01965	COG3012	SEC-C Motif Domain Protein
GO005_01970	COG3290	protein histidine kinase activity
GO005_01975	COG3279	Response regulator of the LytR AlgR family
GO005_01980	COG4555	ABC transporter
GO005_01985	COG1668	transmembrane transport
GO005_01990	COG0667	Aldo Keto reductase
GO005_02005	COG1595	DNA-templated transcription, initiation
GO005_02010	COG1595	DNA-templated transcription, initiation
GO005_02015	COG1876	peptidase activity
GO005_02020	COG0457	Tetratricopeptide repeat
GO005_02025	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_02030	COG0366	Alpha amylase catalytic
GO005_02035	COG0803	Belongs to the bacterial solute-binding protein 9 family
GO005_02040	COG1121	(ABC) transporter
GO005_02045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO005_02050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO005_02055	COG2310	stress, protein
GO005_02060	COG2310	stress, protein
GO005_02065	COG2310	stress, protein
GO005_02070	COG0861	Integral membrane protein TerC family
GO005_02080	COG3853	Toxic anion resistance protein (TelA)
GO005_02085	COG0477	Major facilitator Superfamily
GO005_02090	COG2814	Major facilitator Superfamily
GO005_02095	COG0640	Transcriptional regulator
GO005_02100	COG4175	Glycine betaine
GO005_02100	COG0517	IMP dehydrogenase activity
GO005_02105	COG4176	ABC-type proline glycine betaine transport system permease component
GO005_02110	COG2113	Glycine betaine
GO005_02115	COG1473	amidohydrolase
GO005_02120	COG1288	antiporter activity
GO005_02130	COG0366	Alpha amylase catalytic
GO005_02135	COG0039	L-malate dehydrogenase activity
GO005_02140	COG1620	l-lactate permease
GO005_02145	COG2814	Major facilitator Superfamily
GO005_02150	COG1846	Transcriptional regulator
GO005_02155	COG1280	lysine exporter protein (LysE YggA)
GO005_02160	COG3403	YqcI/YcgG family
GO005_02165	COG1113	amino acid transport
GO005_02170	COG3665	Urea carboxylase-associated protein
GO005_02175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GO005_02180	COG1660	Displays ATPase and GTPase activities
GO005_02185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO005_02190	COG2226	methyltransferase
GO005_02195	COG0583	DNA-binding transcription factor activity
GO005_02200	COG3458	cephalosporin-C deacetylase activity
GO005_02205	COG3541	Predicted nucleotidyltransferase
GO005_02210	COG0506	proline dehydrogenase activity
GO005_02215	COG1012	belongs to the aldehyde dehydrogenase family
GO005_02220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO005_02225	COG2508	Transcriptional regulator
GO005_02230	COG3689	TIGRFAM TIGR03943 family protein
GO005_02235	COG0701	Predicted permease
GO005_02240	COG2267	carboxylic ester hydrolase activity
GO005_02245	COG0492	ferredoxin-NADP+ reductase activity
GO005_02250	COG1587	Uroporphyrinogen-III synthase
GO005_02250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO005_02255	COG2146	nitrite reductase [NAD(P)H] activity
GO005_02260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO005_02265	COG0243	molybdopterin cofactor binding
GO005_02270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO005_02275	COG2223	nitrite transmembrane transporter activity
GO005_02280	COG1469	GTP cyclohydrolase I activity
GO005_02290	COG0523	cobalamin synthesis protein
GO005_02295	COG0765	amino acid transport
GO005_02300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO005_02310	COG1714	RDD family
GO005_02320	COG2723	6-phospho-beta-galactosidase activity
GO005_02330	COG3209	COG3209 Rhs family protein
GO005_02335	COG3290	protein histidine kinase activity
GO005_02335	COG0840	transmembrane signaling receptor activity
GO005_02340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO005_02345	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GO005_02350	COG1733	regulation of RNA biosynthetic process
GO005_02355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_02360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_02365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_02370	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GO005_02375	COG2814	Major facilitator Superfamily
GO005_02385	COG0697	spore germination
GO005_02400	COG2364	Membrane
GO005_02405	COG1126	abc transporter atp-binding protein
GO005_02410	COG0765	amino acid transport
GO005_02415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO005_02420	COG0583	DNA-binding transcription factor activity
GO005_02425	COG0163	prenyltransferase activity
GO005_02430	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO005_02445	COG0596	Alpha beta hydrolase
GO005_02450	COG3104	oligopeptide transport
GO005_02455	COG5434	Belongs to the glycosyl hydrolase 28 family
GO005_02465	COG0697	spore germination
GO005_02475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GO005_02480	COG1136	(ABC) transporter
GO005_02485	COG0577	efflux transmembrane transporter activity
GO005_02490	COG0745	RESPONSE REGULATOR receiver
GO005_02495	COG5002	protein histidine kinase activity
GO005_02495	COG3850	Histidine kinase
GO005_02500	COG0457	Tetratricopeptide repeat
GO005_02520	COG0527	aspartate kinase activity
GO005_02525	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_02530	COG4605	iron ion homeostasis
GO005_02535	COG4604	ABC transporter, ATP-binding protein
GO005_02540	COG4607	ABC-type enterochelin transport system periplasmic component
GO005_02545	COG2814	Major facilitator Superfamily
GO005_02550	COG1309	transcriptional regulator
GO005_02555	COG0778	Nitroreductase
GO005_02560	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO005_02565	COG0640	Transcriptional regulator
GO005_02570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO005_02575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO005_02580	COG1012	belongs to the aldehyde dehydrogenase family
GO005_02585	COG4975	Glucose uptake
GO005_02590	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_02595	COG4549	nuclear export factor GLE1
GO005_02600	COG1276	copper resistance
GO005_02600	COG2372	response to copper ion
GO005_02605	COG1349	DNA-binding transcription factor activity
GO005_02615	COG2213	PTS system mannitol-specific
GO005_02620	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO005_02625	COG0246	Mannitol dehydrogenase
GO005_02630	COG0473	3-isopropylmalate dehydrogenase activity
GO005_02635	COG0681	Belongs to the peptidase S26 family
GO005_02640	COG0412	Dienelactone hydrolase
GO005_02645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO005_02655	COG0561	phosphatase activity
GO005_02660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GO005_02665	COG1914	H( )-stimulated, divalent metal cation uptake system
GO005_02670	COG4336	lyase activity
GO005_02675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GO005_02680	COG1984	allophanate hydrolase subunit 2
GO005_02685	COG1414	Transcriptional regulator
GO005_02690	COG2755	lipolytic protein G-D-S-L family
GO005_02700	COG2329	Antibiotic biosynthesis monooxygenase
GO005_02705	COG0768	penicillin binding
GO005_02710	COG4989	oxidoreductase activity
GO005_02715	COG3711	transcriptional antiterminator
GO005_02720	COG0318	PFAM AMP-dependent synthetase and ligase
GO005_02725	COG2226	methyltransferase
GO005_02730	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_02735	COG1917	Cupin 2, conserved barrel domain protein
GO005_02740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO005_02745	COG3871	stress protein (general stress protein 26)
GO005_02755	COG2814	Major facilitator Superfamily
GO005_02760	COG1522	sequence-specific DNA binding
GO005_02765	COG0551	DNA topoisomerase type I activity
GO005_02765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO005_02770	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GO005_02775	COG3706	GGDEF domain
GO005_02780	COG5298	Protein conserved in bacteria
GO005_02785	COG1215	transferase activity, transferring glycosyl groups
GO005_02795	COG0531	amino acid
GO005_02800	COG0494	nUDIX hydrolase
GO005_02805	COG0028	Belongs to the TPP enzyme family
GO005_02820	COG1914	H( )-stimulated, divalent metal cation uptake system
GO005_02825	COG2261	transglycosylase associated protein
GO005_02830	COG4876	unkown
GO005_02835	COG2217	Heavy metal translocating P-type atpase
GO005_02840	COG3729	General stress protein
GO005_02845	COG0662	Cupin 2, conserved barrel domain protein
GO005_02850	COG2329	Antibiotic biosynthesis monooxygenase
GO005_02855	COG3546	catalase activity
GO005_02860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO005_02865	COG3290	protein histidine kinase activity
GO005_02870	COG4565	transcriptional regulatory protein
GO005_02875	COG1301	dicarboxylic acid transport
GO005_02880	COG0628	permease
GO005_02885	COG1131	(ABC) transporter
GO005_02890	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GO005_02900	COG1960	acyl-CoA dehydrogenase activity
GO005_02915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO005_02920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_02925	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO005_02930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO005_02935	COG0513	Belongs to the DEAD box helicase family
GO005_02940	COG3402	PFAM membrane-flanked domain
GO005_02945	COG3428	Bacterial PH domain
GO005_02950	COG0705	Rhomboid family
GO005_02955	COG0736	holo-[acyl-carrier-protein] synthase activity
GO005_02960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GO005_02965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO005_02970	COG0864	Transcriptional regulator
GO005_02975	COG2337	Toxic component of a toxin-antitoxin (TA) module
GO005_02980	COG1366	Belongs to the anti-sigma-factor antagonist family
GO005_02985	COG1366	Belongs to the anti-sigma-factor antagonist family
GO005_02990	COG2172	sigma factor antagonist activity
GO005_02995	COG2208	phosphoserine phosphatase activity
GO005_03000	COG1366	Belongs to the anti-sigma-factor antagonist family
GO005_03005	COG2172	sigma factor antagonist activity
GO005_03010	COG1191	sigma factor activity
GO005_03015	COG2208	phosphoserine phosphatase activity
GO005_03020	COG2183	response to ionizing radiation
GO005_03030	COG3091	SprT-like family
GO005_03070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO005_03085	COG1476	TRANSCRIPTIONal
GO005_03090	COG3239	Fatty acid desaturase
GO005_03095	COG1278	Cold shock
GO005_03100	COG1329	Transcriptional regulator
GO005_03105	COG0697	spore germination
GO005_03110	COG2207	Transcriptional regulator
GO005_03110	COG1917	Cupin 2, conserved barrel domain protein
GO005_03115	COG0697	spore germination
GO005_03120	COG2207	Transcriptional regulator
GO005_03120	COG3708	Transcriptional regulator
GO005_03125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO005_03130	COG0477	Major facilitator Superfamily
GO005_03140	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GO005_03155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO005_03160	COG1309	transcriptional regulator
GO005_03165	COG0697	spore germination
GO005_03170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO005_03175	COG2030	dehydratase
GO005_03180	COG3545	Serine hydrolase
GO005_03185	COG1733	regulation of RNA biosynthetic process
GO005_03190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO005_03195	COG2814	Major facilitator Superfamily
GO005_03200	COG1309	transcriptional regulator
GO005_03205	COG0640	Transcriptional regulator
GO005_03210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GO005_03220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO005_03225	COG0697	spore germination
GO005_03230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO005_03235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO005_03240	COG0640	Transcriptional regulator
GO005_03245	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO005_03260	COG4585	Histidine kinase
GO005_03265	COG2197	response regulator
GO005_03270	COG2409	Drug exporters of the RND superfamily
GO005_03275	COG0596	Alpha beta hydrolase
GO005_03280	COG1811	Na channel or pump
GO005_03285	COG4978	Transcriptional regulator
GO005_03285	COG0789	Transcriptional regulator
GO005_03290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO005_03295	COG0778	Nitroreductase
GO005_03300	COG0346	lactoylglutathione lyase activity
GO005_03305	COG2259	Doxx family
GO005_03310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_03325	COG2323	membrane
GO005_03330	COG2323	membrane
GO005_03335	COG0071	Belongs to the small heat shock protein (HSP20) family
GO005_03350	COG1309	transcriptional regulator
GO005_03360	COG0456	acetyltransferase
GO005_03365	COG0488	(ABC) transporter
GO005_03370	COG1113	amino acid transport
GO005_03375	COG2318	DinB family
GO005_03380	COG1846	Transcriptional regulator
GO005_03385	COG1033	growth of symbiont in host cell
GO005_03385	COG2409	Drug exporters of the RND superfamily
GO005_03390	COG0778	Nitroreductase
GO005_03395	COG1846	Transcriptional regulator
GO005_03400	COG2814	Major facilitator Superfamily
GO005_03405	COG0730	response to heat
GO005_03410	COG1802	Transcriptional regulator
GO005_03415	COG3858	chitin binding
GO005_03415	COG1388	LysM domain
GO005_03420	COG1819	glycosyl
GO005_03430	COG1785	Belongs to the alkaline phosphatase family
GO005_03435	COG5646	InterPro IPR014922
GO005_03445	COG0454	-acetyltransferase
GO005_03450	COG1078	dGTPase activity
GO005_03455	COG1388	LysM domain
GO005_03460	COG2814	Major facilitator Superfamily
GO005_03465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO005_03470	COG1447	Phosphotransferase system cellobiose-specific component IIA
GO005_03475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO005_03480	COG2723	6-phospho-beta-galactosidase activity
GO005_03485	COG2188	Transcriptional regulator
GO005_03490	COG1940	carbohydrate kinase activity
GO005_03495	COG1482	cell wall glycoprotein biosynthetic process
GO005_03500	COG4124	Belongs to the glycosyl hydrolase 26 family
GO005_03545	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GO005_03550	COG0802	atpase or kinase
GO005_03555	COG1214	PFAM Peptidase M22, glycoprotease
GO005_03560	COG0456	acetyltransferase
GO005_03565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GO005_03570	COG0488	(ABC) transporter
GO005_03575	COG0315	cyclic pyranopterin monophosphate synthase activity
GO005_03580	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GO005_03585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO005_03590	COG0805	protein transport
GO005_03600	COG1266	CAAX protease self-immunity
GO005_03610	COG0459	protein refolding
GO005_03620	COG1073	alpha beta
GO005_03625	COG0457	Tetratricopeptide repeat
GO005_03630	COG1063	alcohol dehydrogenase
GO005_03635	COG2211	Major facilitator Superfamily
GO005_03640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO005_03645	COG1842	Phage shock protein A
GO005_03650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO005_03655	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GO005_03660	COG4260	virion core protein, lumpy skin disease virus
GO005_03670	COG2814	Major facilitator Superfamily
GO005_03675	COG1063	alcohol dehydrogenase
GO005_03680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO005_03685	COG0823	Involved in the tonB-independent uptake of proteins
GO005_03700	COG2267	carboxylic ester hydrolase activity
GO005_03710	COG2132	Multicopper oxidase
GO005_03715	COG1113	amino acid transport
GO005_03725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO005_03730	COG0714	Associated with various cellular activities
GO005_03735	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GO005_03740	COG1305	Transglutaminase-like
GO005_03745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO005_03745	COG0519	Catalyzes the synthesis of GMP from XMP
GO005_03750	COG2252	PERMEase
GO005_03755	COG3064	Membrane
GO005_03765	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GO005_03775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GO005_03780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO005_03785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO005_03790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO005_03795	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO005_03800	COG0047	phosphoribosylformylglycinamidine synthase activity
GO005_03805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO005_03810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GO005_03815	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GO005_03820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO005_03825	COG0138	bifunctional purine biosynthesis protein purh
GO005_03830	COG0151	Belongs to the GarS family
GO005_03835	COG1522	sequence-specific DNA binding
GO005_03840	COG0531	amino acid
GO005_03850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GO005_03855	COG1470	cell adhesion involved in biofilm formation
GO005_03860	COG4496	protein, YerC YecD
GO005_03865	COG0069	glutamate synthase activity
GO005_03870	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GO005_03875	COG0210	DNA helicase
GO005_03880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GO005_03885	COG4851	CamS sex pheromone cAM373 precursor
GO005_03890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO005_03895	COG1285	pathogenesis
GO005_03900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO005_03905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GO005_03910	COG0154	amidase activity
GO005_03915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GO005_03920	COG1309	transcriptional regulator
GO005_03925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO005_03930	COG1597	lipid kinase activity
GO005_03935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO005_03960	COG5444	nuclease activity
GO005_03980	COG0457	Tetratricopeptide repeat
GO005_03990	COG0217	transcriptional regulatory protein
GO005_04000	COG1309	transcriptional regulator
GO005_04005	COG3631	Ketosteroid isomerase-related protein
GO005_04010	COG0702	epimerase
GO005_04025	COG3546	catalase activity
GO005_04030	COG0454	-acetyltransferase
GO005_04040	COG5578	integral membrane protein
GO005_04045	COG2972	Histidine kinase
GO005_04050	COG2207	Transcriptional regulator
GO005_04050	COG4753	response regulator
GO005_04055	COG1653	transport
GO005_04060	COG1175	transmembrane transport
GO005_04065	COG0395	ABC-type sugar transport system, permease component
GO005_04070	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GO005_04075	COG2207	Transcriptional regulator
GO005_04080	COG2755	lipolytic protein G-D-S-L family
GO005_04090	COG5578	integral membrane protein
GO005_04095	COG3401	FG-GAP repeat protein
GO005_04100	COG3401	FG-GAP repeat protein
GO005_04105	COG2755	lipolytic protein G-D-S-L family
GO005_04110	COG1874	Beta-galactosidase
GO005_04120	COG1653	transport
GO005_04125	COG4209	transmembrane transport
GO005_04130	COG0395	ABC-type sugar transport system, permease component
GO005_04135	COG1486	melibiose metabolic process
GO005_04140	COG2323	membrane
GO005_04145	COG2329	Antibiotic biosynthesis monooxygenase
GO005_04150	COG0346	lactoylglutathione lyase activity
GO005_04165	COG5583	Uncharacterized small protein (DUF2292)
GO005_04170	COG0670	Belongs to the BI1 family
GO005_04175	COG0697	spore germination
GO005_04180	COG1846	Transcriptional regulator
GO005_04185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO005_04195	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO005_04195	COG2124	cytochrome p450
GO005_04200	COG1368	sulfuric ester hydrolase activity
GO005_04205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GO005_04210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO005_04215	COG1442	glycosyl transferase family 8
GO005_04220	COG1216	Glycosyl transferase, family 2
GO005_04225	COG1442	glycosyl transferase family 8
GO005_04230	COG2223	nitrite transmembrane transporter activity
GO005_04235	COG1011	Hydrolase
GO005_04240	COG0531	amino acid
GO005_04245	COG1012	belongs to the aldehyde dehydrogenase family
GO005_04250	COG0840	transmembrane signaling receptor activity
GO005_04255	COG0488	(ABC) transporter
GO005_04265	COG0789	Transcriptional regulator
GO005_04270	COG2814	Major facilitator Superfamily
GO005_04280	COG0488	(ABC) transporter
GO005_04285	COG0513	Belongs to the DEAD box helicase family
GO005_04290	COG0456	acetyltransferase
GO005_04295	COG2130	NADP-dependent
GO005_04300	COG2211	Major facilitator Superfamily
GO005_04305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GO005_04310	COG1120	ATPase activity
GO005_04315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_04320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_04325	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO005_04340	COG3866	Pectate lyase
GO005_04345	COG0471	metal ion transport
GO005_04350	COG3290	protein histidine kinase activity
GO005_04355	COG4565	transcriptional regulatory protein
GO005_04360	COG3181	Tripartite tricarboxylate transporter family receptor
GO005_04365	COG2851	Citrate transporter
GO005_04370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO005_04375	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GO005_04380	COG1254	Belongs to the acylphosphatase family
GO005_04385	COG2258	MOSC domain
GO005_04405	COG0024	Methionine aminopeptidase
GO005_04410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_04410	COG1263	PTS System
GO005_04415	COG1368	sulfuric ester hydrolase activity
GO005_04430	COG1115	amino acid carrier protein
GO005_04435	COG0531	amino acid
GO005_04455	COG1263	PTS System
GO005_04455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_04460	COG0366	Alpha amylase catalytic
GO005_04465	COG2188	Transcriptional regulator
GO005_04470	COG0778	Nitroreductase
GO005_04475	COG0737	Belongs to the 5'-nucleotidase family
GO005_04480	COG0693	protein deglycase activity
GO005_04485	COG2814	Major facilitator Superfamily
GO005_04490	COG4840	Belongs to the UPF0435 family
GO005_04495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO005_04500	COG4980	gas vesicle protein
GO005_04505	COG1295	ribonuclease BN
GO005_04510	COG0477	Major facilitator Superfamily
GO005_04515	COG0387	Pfam Sodium calcium exchanger
GO005_04525	COG0668	transmembrane transport
GO005_04530	COG0535	radical SAM domain protein
GO005_04540	COG0726	polysaccharide deacetylase
GO005_04545	COG2084	Dehydrogenase
GO005_04550	COG0598	Magnesium transport protein CorA
GO005_04555	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO005_04560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO005_04570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO005_04575	COG4637	Psort location Cytoplasmic, score
GO005_04585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO005_04590	COG0022	dehydrogenase e1 component
GO005_04595	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO005_04600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO005_04605	COG3284	Transcriptional regulator
GO005_04615	COG1742	UPF0060 membrane protein
GO005_04640	COG4842	Belongs to the WXG100 family
GO005_04645	COG1486	melibiose metabolic process
GO005_04650	COG1737	Transcriptional regulator
GO005_04655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_04655	COG1263	PTS System
GO005_04660	COG1132	(ABC) transporter
GO005_04665	COG1132	(ABC) transporter
GO005_04670	COG2259	Doxx family
GO005_04675	COG2514	catechol 2,3-dioxygenase activity
GO005_04680	COG1917	Cupin 2, conserved barrel domain protein
GO005_04680	COG4977	sequence-specific DNA binding
GO005_04685	COG2814	Major facilitator Superfamily
GO005_04690	COG1082	Xylose isomerase domain protein TIM barrel
GO005_04695	COG0673	inositol 2-dehydrogenase activity
GO005_04700	COG4585	Histidine kinase
GO005_04705	COG2197	response regulator
GO005_04710	COG1131	(ABC) transporter
GO005_04715	COG1511	domain protein
GO005_04715	COG0842	Transport permease protein
GO005_04720	COG0842	Transport permease protein
GO005_04725	COG1695	Transcriptional regulator
GO005_04730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO005_04735	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GO005_04740	COG1309	transcriptional regulator
GO005_04745	COG2814	Major facilitator Superfamily
GO005_04750	COG2318	DinB family
GO005_04755	COG2814	Major facilitator Superfamily
GO005_04760	COG1846	Transcriptional regulator
GO005_04765	COG0392	lysyltransferase activity
GO005_04765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GO005_04770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO005_04775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_04780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_04785	COG0384	phenazine biosynthesis protein PhzF
GO005_04790	COG0778	Nitroreductase
GO005_04805	COG1090	epimerase
GO005_04810	COG2137	regulation of response to DNA damage stimulus
GO005_04820	COG2814	Major facilitator Superfamily
GO005_04835	COG3103	Sh3 type 3 domain protein
GO005_04840	COG5658	integral membrane protein
GO005_04845	COG0596	Alpha beta hydrolase
GO005_04850	COG0463	Glycosyl transferase, family 2
GO005_04855	COG4485	Bacterial membrane protein, YfhO
GO005_04860	COG1988	membrane-bound metal-dependent
GO005_04865	COG1194	a g-specific adenine glycosylase
GO005_04875	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_04890	COG3557	Belongs to the UPF0374 family
GO005_04895	COG1132	(ABC) transporter
GO005_04900	COG4129	membrane
GO005_04905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO005_04910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO005_04915	COG0735	belongs to the Fur family
GO005_05025	COG4326	sporulation control protein
GO005_05035	COG5577	PFAM Coat F domain
GO005_05045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GO005_05050	COG0277	FAD linked oxidase domain protein
GO005_05060	COG0753	catalase activity
GO005_05065	COG1116	anion transmembrane transporter activity
GO005_05070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO005_05075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO005_05080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO005_05090	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GO005_05100	COG1476	TRANSCRIPTIONal
GO005_05110	COG3382	B3 4 domain protein
GO005_05115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GO005_05125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO005_05130	COG0789	Transcriptional regulator
GO005_05135	COG1664	Polymer-forming cytoskeletal
GO005_05140	COG1664	Polymer-forming cytoskeletal
GO005_05145	COG2766	serine protein kinase
GO005_05150	COG2718	Belongs to the UPF0229 family
GO005_05155	COG1846	Transcriptional regulator
GO005_05160	COG1566	PFAM secretion protein HlyD family protein
GO005_05165	COG2814	Major facilitator Superfamily
GO005_05170	COG0655	NAD(P)H dehydrogenase (quinone) activity
GO005_05190	COG1725	Transcriptional regulator
GO005_05195	COG1131	(ABC) transporter
GO005_05200	COG1131	(ABC) transporter
GO005_05205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GO005_05210	COG1278	Cold shock
GO005_05215	COG1464	Belongs to the NlpA lipoprotein family
GO005_05220	COG3706	GGDEF domain
GO005_05225	COG1823	symporter activity
GO005_05245	COG5577	PFAM Coat F domain
GO005_05250	COG0737	Belongs to the 5'-nucleotidase family
GO005_05250	COG1525	nuclease
GO005_05250	COG4085	toxin activity
GO005_05255	COG3764	Sortase (surface protein transpeptidase)
GO005_05260	COG0564	pseudouridine synthase activity
GO005_05270	COG0517	IMP dehydrogenase activity
GO005_05275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO005_05280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO005_05280	COG3153	acetyltransferase
GO005_05285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO005_05290	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GO005_05295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO005_05300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO005_05305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO005_05310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO005_05315	COG4585	Histidine kinase
GO005_05315	COG2203	Gaf domain
GO005_05320	COG2197	response regulator
GO005_05325	COG0431	NADPH-dependent FMN reductase
GO005_05340	COG1388	LysM domain
GO005_05340	COG0791	NLP P60 protein
GO005_05345	COG1959	2 iron, 2 sulfur cluster binding
GO005_05350	COG0668	transmembrane transport
GO005_05355	COG2719	SpoVR family
GO005_05360	COG1785	Belongs to the alkaline phosphatase family
GO005_05365	COG0791	NLP P60 protein
GO005_05365	COG1388	LysM domain
GO005_05370	COG0583	DNA-binding transcription factor activity
GO005_05375	COG0372	Belongs to the citrate synthase family
GO005_05380	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_05385	COG0531	amino acid
GO005_05390	COG0733	neurotransmitter:sodium symporter activity
GO005_05395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO005_05400	COG0456	acetyltransferase
GO005_05415	COG1595	DNA-templated transcription, initiation
GO005_05420	COG0667	Aldo Keto reductase
GO005_05425	COG0204	Acyl-transferase
GO005_05430	COG1253	flavin adenine dinucleotide binding
GO005_05435	COG0789	Transcriptional regulator
GO005_05440	COG0436	Aminotransferase
GO005_05445	COG1253	flavin adenine dinucleotide binding
GO005_05450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO005_05455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO005_05460	COG0584	glycerophosphoryl diester phosphodiesterase
GO005_05470	COG0668	transmembrane transport
GO005_05475	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GO005_05480	COG0726	polysaccharide deacetylase
GO005_05485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO005_05490	COG1757	Na H antiporter
GO005_05495	COG0589	response to stress
GO005_05505	COG1132	(ABC) transporter
GO005_05510	COG1132	(ABC) transporter
GO005_05515	COG0702	epimerase
GO005_05535	COG0189	ligase activity
GO005_05540	COG0189	ligase activity
GO005_05545	COG4399	Belongs to the UPF0754 family
GO005_05550	COG3679	Belongs to the UPF0342 family
GO005_05555	COG4335	DNA alkylation repair
GO005_05560	COG0561	phosphatase activity
GO005_05565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO005_05570	COG0475	glutathione-regulated potassium exporter activity
GO005_05575	COG0490	domain, Protein
GO005_05585	COG1024	Enoyl-CoA hydratase
GO005_05595	COG4152	abc transporter atp-binding protein
GO005_05600	COG1668	transmembrane transport
GO005_05605	COG0420	3'-5' exonuclease activity
GO005_05610	COG4717	serine-type aminopeptidase activity
GO005_05615	COG3481	metal-dependent phosphohydrolase, HD sub domain
GO005_05625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO005_05655	COG1846	Transcriptional regulator
GO005_05660	COG4980	gas vesicle protein
GO005_05675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GO005_05680	COG0537	adenosine 5'-monophosphoramidase activity
GO005_05685	COG1131	(ABC) transporter
GO005_05690	COG4473	ABC transporter
GO005_05700	COG1473	amidohydrolase
GO005_05705	COG3069	C4-dicarboxylate transmembrane transporter activity
GO005_05715	COG2329	Antibiotic biosynthesis monooxygenase
GO005_05720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO005_05725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GO005_05730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GO005_05735	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GO005_05740	COG1309	transcriptional regulator
GO005_05745	COG1511	domain protein
GO005_05750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO005_05755	COG4377	Putative membrane peptidase family (DUF2324)
GO005_05765	COG1363	Peptidase, m42
GO005_05770	COG4405	Protein conserved in bacteria
GO005_05775	COG1301	dicarboxylic acid transport
GO005_05785	COG1234	tRNA 3'-trailer cleavage
GO005_05790	COG0095	Lipoate-protein ligase
GO005_05795	COG0702	epimerase
GO005_05800	COG0318	PFAM AMP-dependent synthetase and ligase
GO005_05810	COG0501	Belongs to the peptidase M48B family
GO005_05820	COG0456	acetyltransferase
GO005_05825	COG0604	alcohol dehydrogenase
GO005_05830	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO005_05835	COG0406	alpha-ribazole phosphatase activity
GO005_05840	COG0183	Belongs to the thiolase family
GO005_05845	COG0318	PFAM AMP-dependent synthetase and ligase
GO005_05850	COG1268	BioY protein
GO005_05855	COG0840	transmembrane signaling receptor activity
GO005_05860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO005_05860	COG0723	plastoquinol--plastocyanin reductase activity
GO005_05865	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_05875	COG4903	ComK protein
GO005_05880	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_05890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO005_05905	COG0398	Pfam SNARE associated Golgi protein
GO005_05910	COG0681	Belongs to the peptidase S26 family
GO005_05915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO005_05920	COG1846	Transcriptional regulator
GO005_05925	COG0738	Major facilitator superfamily
GO005_05930	COG0673	inositol 2-dehydrogenase activity
GO005_05935	COG0561	phosphatase activity
GO005_05940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO005_05945	COG1609	Transcriptional regulator
GO005_05950	COG3180	Ammonia monooxygenase
GO005_05955	COG0477	Major facilitator Superfamily
GO005_05955	COG2814	Major facilitator Superfamily
GO005_05960	COG4533	DNA binding
GO005_05970	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GO005_05975	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GO005_05980	COG1074	ATP-dependent DNA helicase activity
GO005_05985	COG0420	3'-5' exonuclease activity
GO005_05990	COG0419	ATPase involved in DNA repair
GO005_05995	COG1403	HNH endonuclease
GO005_06035	COG5337	Spore coat protein CotH
GO005_06040	COG0179	Fumarylacetoacetate (FAA) hydrolase
GO005_06050	COG1404	Belongs to the peptidase S8 family
GO005_06060	COG0367	asparagine synthase
GO005_06065	COG2318	DinB family
GO005_06070	COG1562	ergosterol biosynthetic process
GO005_06075	COG0534	Mate efflux family protein
GO005_06080	COG1917	Cupin 2, conserved barrel domain protein
GO005_06080	COG2207	Transcriptional regulator
GO005_06085	COG1609	Transcriptional regulator
GO005_06090	COG0673	inositol 2-dehydrogenase activity
GO005_06095	COG2318	DinB family
GO005_06100	COG1279	arginine transmembrane transporter activity
GO005_06105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO005_06110	COG1357	PFAM Pentapeptide repeats (8 copies)
GO005_06115	COG2267	carboxylic ester hydrolase activity
GO005_06120	COG0529	Catalyzes the synthesis of activated sulfate
GO005_06125	COG2046	Belongs to the sulfate adenylyltransferase family
GO005_06130	COG0175	sulfate reduction
GO005_06135	COG2045	Belongs to the ComB family
GO005_06140	COG1809	phosphosulfolactate synthase activity
GO005_06145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO005_06150	COG4948	Mandelate Racemase Muconate Lactonizing
GO005_06155	COG2814	Major facilitator Superfamily
GO005_06160	COG0454	-acetyltransferase
GO005_06165	COG2153	protein acetylation
GO005_06170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GO005_06170	COG0646	methionine synthase
GO005_06175	COG1666	GTP binding
GO005_06180	COG2996	Protein conserved in bacteria
GO005_06200	COG1695	Transcriptional regulator
GO005_06215	COG3227	Zinc metalloprotease (Elastase)
GO005_06220	COG1307	EDD domain protein, DegV family
GO005_06225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO005_06240	COG0561	phosphatase activity
GO005_06245	COG1073	alpha beta
GO005_06250	COG2151	metal-sulfur cluster biosynthetic enzyme
GO005_06260	COG0277	FAD linked oxidase domain protein
GO005_06265	COG2271	Major facilitator Superfamily
GO005_06270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GO005_06275	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GO005_06285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO005_06290	COG0505	Belongs to the CarA family
GO005_06295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO005_06300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO005_06315	COG2267	carboxylic ester hydrolase activity
GO005_06325	COG1744	ABC transporter substrate-binding protein PnrA-like
GO005_06340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO005_06345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO005_06350	COG5504	Zn-dependent protease
GO005_06355	COG0444	Belongs to the ABC transporter superfamily
GO005_06360	COG4608	Belongs to the ABC transporter superfamily
GO005_06370	COG0601	transmembrane transport
GO005_06375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO005_06385	COG0180	Tryptophanyl-tRNA synthetase
GO005_06390	COG4166	transmembrane transport
GO005_06395	COG0601	transmembrane transport
GO005_06400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO005_06405	COG0444	Belongs to the ABC transporter superfamily
GO005_06410	COG4608	Belongs to the ABC transporter superfamily
GO005_06415	COG2814	Major facilitator Superfamily
GO005_06420	COG0456	acetyltransferase
GO005_06425	COG1393	Belongs to the ArsC family
GO005_06430	COG0861	Integral membrane protein TerC family
GO005_06440	COG4862	establishment of competence for transformation
GO005_06450	COG4469	Competence protein
GO005_06455	COG1164	Oligoendopeptidase f
GO005_06465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GO005_06470	COG2346	COG2346, Truncated hemoglobins
GO005_06475	COG0741	lytic transglycosylase activity
GO005_06480	COG4116	CYTH
GO005_06490	COG2357	RelA SpoT domain protein
GO005_06495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO005_06500	COG0564	pseudouridine synthase activity
GO005_06505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO005_06510	COG0569	domain protein
GO005_06510	COG0475	glutathione-regulated potassium exporter activity
GO005_06515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GO005_06520	COG0352	thiamine-phosphate diphosphorylase activity
GO005_06525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO005_06530	COG2104	thiamine diphosphate biosynthetic process
GO005_06535	COG2022	thiamine diphosphate biosynthetic process
GO005_06540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO005_06545	COG0351	phosphomethylpyrimidine kinase
GO005_06550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO005_06605	COG0210	DNA helicase
GO005_06615	COG2153	protein acetylation
GO005_06620	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GO005_06625	COG2382	esterase
GO005_06630	COG0626	cystathionine gamma-synthase activity
GO005_06635	COG0626	cystathionine gamma-synthase activity
GO005_06640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO005_06645	COG5505	Protein of unknown function (DUF819)
GO005_06670	COG5444	nuclease activity
GO005_06715	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO005_06720	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_06730	COG3711	transcriptional antiterminator
GO005_06730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO005_06735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO005_06735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO005_06735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO005_06740	COG1482	cell wall glycoprotein biosynthetic process
GO005_06750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO005_06760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GO005_06775	COG0109	protoheme IX farnesyltransferase activity
GO005_06785	COG0726	polysaccharide deacetylase
GO005_06800	COG5504	Zn-dependent protease
GO005_06805	COG2205	protein histidine kinase activity
GO005_06815	COG3383	formate dehydrogenase (NAD+) activity
GO005_06820	COG2427	Protein of unknown function (DUF1641)
GO005_06830	COG1051	belongs to the nudix hydrolase family
GO005_06840	COG2124	cytochrome p450
GO005_06845	COG1819	glycosyl
GO005_06855	COG1587	Uroporphyrinogen-III synthase
GO005_06860	COG0390	transport system, permease component
GO005_06865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO005_06870	COG0697	spore germination
GO005_06875	COG4297	protein containing double-stranded beta helix domain
GO005_06885	COG1252	NADH dehydrogenase
GO005_06890	COG1904	glucuronate isomerase
GO005_06895	COG2211	Major facilitator Superfamily
GO005_06900	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GO005_06905	COG1063	alcohol dehydrogenase
GO005_06910	COG1312	Catalyzes the dehydration of D-mannonate
GO005_06915	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_06920	COG2271	Major facilitator Superfamily
GO005_06925	COG1609	Transcriptional regulator
GO005_06930	COG0246	Mannitol dehydrogenase
GO005_06935	COG2721	sulfolactate sulfo-lyase activity
GO005_06940	COG0730	response to heat
GO005_06945	COG2318	DinB family
GO005_06950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO005_06955	COG0457	Tetratricopeptide repeat
GO005_06965	COG2350	Protein conserved in bacteria
GO005_06970	COG3409	Peptidoglycan-binding domain 1 protein
GO005_06970	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO005_06970	COG1388	LysM domain
GO005_06980	COG4195	phage-related replication protein
GO005_06985	COG3546	catalase activity
GO005_06990	COG2856	Zn peptidase
GO005_06995	COG1396	sequence-specific DNA binding
GO005_07005	COG1522	sequence-specific DNA binding
GO005_07010	COG1484	DNA-dependent DNA replication
GO005_07030	COG1595	DNA-templated transcription, initiation
GO005_07035	COG5484	DNA packaging
GO005_07035	COG3728	DNA packaging
GO005_07040	COG1783	phage Terminase large subunit
GO005_07045	COG5518	Phage portal protein
GO005_07050	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO005_07055	COG4653	Phage capsid family
GO005_07105	COG3953	SLT domain
GO005_07105	COG5412	phage tail tape measure protein
GO005_07110	COG1652	LysM domain
GO005_07115	COG4193	domain, Protein
GO005_07125	COG3628	GPW Gp25 family protein
GO005_07130	COG3299	homolog of phage Mu protein gp47
GO005_07135	COG3778	Protein conserved in bacteria
GO005_07175	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO005_07175	COG3409	Peptidoglycan-binding domain 1 protein
GO005_07195	COG0306	phosphate transporter
GO005_07200	COG1392	Phosphate transport regulator
GO005_07205	COG0531	amino acid
GO005_07210	COG0346	lactoylglutathione lyase activity
GO005_07220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO005_07225	COG0463	Glycosyl transferase, family 2
GO005_07230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO005_07235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO005_07240	COG2362	D-Aminopeptidase
GO005_07245	COG0601	transmembrane transport
GO005_07250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO005_07255	COG0444	Belongs to the ABC transporter superfamily
GO005_07260	COG4166	transmembrane transport
GO005_07265	COG1619	proteins homologs of microcin C7 resistance protein MccF
GO005_07270	COG4948	Mandelate Racemase Muconate Lactonizing
GO005_07275	COG0791	NLP P60 protein
GO005_07280	COG4608	Belongs to the ABC transporter superfamily
GO005_07285	COG2706	6-phosphogluconolactonase activity
GO005_07290	COG1834	amidinotransferase
GO005_07295	COG1607	acyl-coa hydrolase
GO005_07300	COG1017	nitric oxide dioxygenase activity
GO005_07300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO005_07310	COG2323	membrane
GO005_07315	COG2318	DinB family
GO005_07320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO005_07325	COG2076	Multidrug Resistance protein
GO005_07330	COG2076	Multidrug Resistance protein
GO005_07335	COG0788	formyltetrahydrofolate deformylase activity
GO005_07340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO005_07345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GO005_07350	COG1764	response to oxidative stress
GO005_07355	COG1846	Transcriptional regulator
GO005_07360	COG1764	response to oxidative stress
GO005_07370	COG0590	tRNA wobble adenosine to inosine editing
GO005_07375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO005_07380	COG1404	Belongs to the peptidase S8 family
GO005_07385	COG1366	Belongs to the anti-sigma-factor antagonist family
GO005_07390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GO005_07395	COG1122	ATPase activity
GO005_07400	COG4721	ABC-type cobalt transport system, permease component
GO005_07410	COG0745	RESPONSE REGULATOR receiver
GO005_07415	COG3850	Histidine kinase
GO005_07415	COG5002	protein histidine kinase activity
GO005_07420	COG3212	peptidase
GO005_07425	COG3212	peptidase
GO005_07435	COG2239	Acts as a magnesium transporter
GO005_07440	COG0789	Transcriptional regulator
GO005_07455	COG1846	Transcriptional regulator
GO005_07460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO005_07465	COG0726	polysaccharide deacetylase
GO005_07470	COG1408	metallophosphoesterase
GO005_07480	COG0463	Glycosyl transferase, family 2
GO005_07485	COG3285	dna ligase
GO005_07485	COG1793	dna ligase
GO005_07490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GO005_07495	COG5001	Diguanylate cyclase
GO005_07495	COG3300	MHYT domain
GO005_07500	COG0586	Pfam SNARE associated Golgi protein
GO005_07505	COG0861	Integral membrane protein TerC family
GO005_07510	COG1191	sigma factor activity
GO005_07530	COG0501	Belongs to the peptidase M48B family
GO005_07535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO005_07550	COG3594	Acyltransferase
GO005_07555	COG5002	protein histidine kinase activity
GO005_07560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO005_07570	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GO005_07575	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GO005_07580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO005_07585	COG0436	Aminotransferase
GO005_07590	COG1850	ribulose-bisphosphate carboxylase activity
GO005_07595	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GO005_07600	COG0235	Class ii aldolase
GO005_07605	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GO005_07610	COG3339	Conserved Protein
GO005_07625	COG3852	Histidine kinase
GO005_07630	COG1846	Transcriptional regulator
GO005_07635	COG1360	Flagellar Motor Protein
GO005_07640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO005_07645	COG0542	response to heat
GO005_07650	COG3949	Membrane
GO005_07655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GO005_07660	COG0720	synthase
GO005_07665	COG0602	queuosine metabolic process
GO005_07670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO005_07675	COG1733	regulation of RNA biosynthetic process
GO005_07680	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_07685	COG1388	LysM domain
GO005_07685	COG4641	Protein conserved in bacteria
GO005_07690	COG1388	LysM domain
GO005_07695	COG3858	chitin binding
GO005_07705	COG4873	Protein conserved in bacteria
GO005_07715	COG3773	Cell wall hydrolase
GO005_07720	COG2244	polysaccharide biosynthetic process
GO005_07725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_07730	COG2217	Heavy metal translocating P-type atpase
GO005_07740	COG0006	proline dipeptidase activity
GO005_07745	COG1609	Transcriptional regulator
GO005_07750	COG3711	transcriptional antiterminator
GO005_07755	COG1263	PTS System
GO005_07755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_07755	COG2190	(PTS) system
GO005_07760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO005_07765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO005_07775	COG1533	DNA photolyase activity
GO005_07780	COG0456	acetyltransferase
GO005_07785	COG0840	transmembrane signaling receptor activity
GO005_07790	COG2084	Dehydrogenase
GO005_07795	COG2340	Cysteine-rich secretory protein family
GO005_07800	COG0768	penicillin binding
GO005_07805	COG4191	Histidine kinase
GO005_07810	COG0436	Aminotransferase
GO005_07820	COG0835	chemotaxis
GO005_07820	COG0784	Response regulator, receiver
GO005_07830	COG2814	Major facilitator Superfamily
GO005_07835	COG1376	ErfK ybiS ycfS ynhG family protein
GO005_07840	COG1408	metallophosphoesterase
GO005_07845	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_07850	COG3409	Peptidoglycan-binding domain 1 protein
GO005_07860	COG2200	EAL domain
GO005_07865	COG4703	Protein of unknown function (DUF1797)
GO005_07870	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GO005_07880	COG0517	IMP dehydrogenase activity
GO005_07885	COG0583	DNA-binding transcription factor activity
GO005_07890	COG0716	FMN binding
GO005_07900	COG0716	FMN binding
GO005_07905	COG2171	N-acyltransferase activity
GO005_07910	COG1473	amidohydrolase
GO005_07920	COG0668	transmembrane transport
GO005_07925	COG0450	alkyl hydroperoxide reductase
GO005_07930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_07945	COG0746	molybdenum cofactor guanylyltransferase activity
GO005_07950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO005_07955	COG0303	'Molybdopterin
GO005_07960	COG1763	Mo-molybdopterin cofactor biosynthetic process
GO005_07965	COG0314	molybdopterin synthase activity
GO005_07970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GO005_07975	COG1132	(ABC) transporter
GO005_07980	COG1132	(ABC) transporter
GO005_07990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO005_07995	COG1136	(ABC) transporter
GO005_08000	COG0577	efflux transmembrane transporter activity
GO005_08005	COG1349	DNA-binding transcription factor activity
GO005_08010	COG1105	Belongs to the carbohydrate kinase PfkB family
GO005_08015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO005_08015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO005_08015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO005_08020	COG0681	Belongs to the peptidase S26 family
GO005_08030	COG0488	(ABC) transporter
GO005_08035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO005_08040	COG2309	aminopeptidase activity
GO005_08050	COG1077	Cell shape determining protein MreB Mrl
GO005_08055	COG2002	toxin-antitoxin pair type II binding
GO005_08060	COG3852	Histidine kinase
GO005_08065	COG2105	PFAM AIG2 family protein
GO005_08065	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GO005_08070	COG0569	domain protein
GO005_08075	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GO005_08080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GO005_08085	COG5503	Protein of unknown function (DUF1447)
GO005_08090	COG0561	phosphatase activity
GO005_08095	COG0242	peptide deformylase activity
GO005_08105	COG0497	DNA recombination
GO005_08110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO005_08115	COG0022	dehydrogenase e1 component
GO005_08120	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO005_08125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO005_08130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_08140	COG1982	Orn Lys Arg decarboxylase major
GO005_08145	COG4476	Belongs to the UPF0223 family
GO005_08150	COG4493	Belongs to the UPF0637 family
GO005_08160	COG0483	inositol monophosphate 1-phosphatase activity
GO005_08170	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GO005_08210	COG1217	gtp-binding protein TYPA
GO005_08220	COG4896	Protein conserved in bacteria
GO005_08230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GO005_08235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GO005_08240	COG2066	Belongs to the glutaminase family
GO005_08245	COG4838	Belongs to the UPF0358 family
GO005_08250	COG0772	Belongs to the SEDS family
GO005_08255	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GO005_08260	COG1612	heme a metabolic process
GO005_08265	COG0109	protoheme IX farnesyltransferase activity
GO005_08270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO005_08270	COG2010	Cytochrome c
GO005_08275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO005_08280	COG1845	cytochrome c oxidase, subunit III
GO005_08285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO005_08290	COG3336	cytochrome c oxidase
GO005_08300	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GO005_08305	COG2340	Cysteine-rich secretory protein family
GO005_08320	COG3679	Belongs to the UPF0342 family
GO005_08325	COG4471	UPF0298 protein
GO005_08330	COG0742	ribosomal rna small subunit methyltransferase
GO005_08335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GO005_08340	COG3314	Sporulation integral membrane protein YlbJ
GO005_08345	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO005_08350	COG3480	Lon protease (S16) C-terminal proteolytic domain
GO005_08355	COG1323	Belongs to the UPF0348 family
GO005_08365	COG1399	metal-binding, possibly nucleic acid-binding protein
GO005_08380	COG0454	-acetyltransferase
GO005_08385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO005_08390	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GO005_08395	COG2001	Belongs to the MraZ family
GO005_08400	COG0275	rRNA processing
GO005_08405	COG4839	cell division protein FtsL
GO005_08410	COG0768	penicillin binding
GO005_08415	COG0768	penicillin binding
GO005_08420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GO005_08425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO005_08430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO005_08435	COG0772	Belongs to the SEDS family
GO005_08440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO005_08445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO005_08450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO005_08455	COG3879	Bacterial protein of unknown function (DUF881)
GO005_08460	COG3879	Bacterial protein of unknown function (DUF881)
GO005_08465	COG3856	small basic protein
GO005_08470	COG0849	cell division
GO005_08475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GO005_08480	COG1404	Belongs to the peptidase S8 family
GO005_08480	COG4412	M6 family metalloprotease domain protein
GO005_08490	COG1191	sigma factor activity
GO005_08495	COG1191	sigma factor activity
GO005_08500	COG1119	ATPase activity
GO005_08505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO005_08510	COG1873	PFAM PRC-barrel domain
GO005_08515	COG1496	oxidoreductase activity
GO005_08520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GO005_08525	COG1799	cell septum assembly
GO005_08530	COG0762	integral membrane protein
GO005_08535	COG2302	S4 RNA-binding domain
GO005_08540	COG3599	regulation of cell shape
GO005_08545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO005_08550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO005_08555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GO005_08560	COG0564	pseudouridine synthase activity
GO005_08565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GO005_08570	COG2233	PERMEase
GO005_08575	COG0540	Belongs to the ATCase OTCase family
GO005_08580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO005_08585	COG0505	Belongs to the CarA family
GO005_08590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO005_08595	COG0543	2 iron, 2 sulfur cluster binding
GO005_08600	COG0167	dihydroorotate dehydrogenase activity
GO005_08605	COG0284	orotidine-5'-phosphate decarboxylase activity
GO005_08610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GO005_08615	COG0175	sulfate reduction
GO005_08620	COG0306	phosphate transporter
GO005_08625	COG2046	Belongs to the sulfate adenylyltransferase family
GO005_08630	COG0529	Catalyzes the synthesis of activated sulfate
GO005_08635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO005_08640	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GO005_08645	COG1648	precorrin-2 dehydrogenase activity
GO005_08650	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GO005_08655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GO005_08660	COG1561	YicC-like family, N-terminal region
GO005_08670	COG0194	GDP metabolic process
GO005_08675	COG1758	RNA polymerase activity
GO005_08680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO005_08685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO005_08690	COG0242	peptide deformylase activity
GO005_08695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO005_08700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO005_08700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO005_08705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GO005_08710	COG0631	protein serine/threonine phosphatase activity
GO005_08715	COG0515	serine threonine protein kinase
GO005_08715	COG2815	serine threonine protein kinase
GO005_08720	COG1162	GTPase activity
GO005_08725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GO005_08730	COG1564	THIamine pyrophosphokinase
GO005_08740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GO005_08745	COG1302	Protein conserved in bacteria
GO005_08750	COG1461	Dihydroxyacetone kinase
GO005_08755	COG1760	l-serine dehydratase
GO005_08760	COG1760	l-serine dehydratase
GO005_08765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GO005_08770	COG1349	DNA-binding transcription factor activity
GO005_08770	COG2050	protein possibly involved in aromatic compounds catabolism
GO005_08775	COG0416	fatty acid biosynthetic process
GO005_08780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO005_08785	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_08795	COG0571	ribonuclease III activity
GO005_08800	COG1196	nuclear chromosome segregation
GO005_08805	COG0552	protein localization to endoplasmic reticulum
GO005_08815	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GO005_08820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO005_08825	COG0228	four-way junction DNA binding
GO005_08830	COG1837	Belongs to the UPF0109 family
GO005_08840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GO005_08845	COG0336	Belongs to the RNA methyltransferase TrmD family
GO005_08850	COG0335	large ribosomal subunit rRNA binding
GO005_08855	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GO005_08860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO005_08870	COG2257	FlhB HrpN YscU SpaS Family
GO005_08875	COG0045	succinate-CoA ligase (ADP-forming) activity
GO005_08880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO005_08885	COG0758	DNA mediated transformation
GO005_08890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO005_08895	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GO005_08900	COG4974	Belongs to the 'phage' integrase family
GO005_08905	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GO005_08910	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GO005_08915	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GO005_08920	COG1815	bacterial-type flagellum-dependent cell motility
GO005_08925	COG1558	bacterial-type flagellum-dependent cell motility
GO005_08930	COG1677	Flagellar hook-basal body complex protein FliE
GO005_08935	COG1766	The M ring may be actively involved in energy transduction
GO005_08940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO005_08945	COG1317	bacterial-type flagellum organization
GO005_08950	COG1157	protein secretion by the type III secretion system
GO005_08955	COG2882	bacterial-type flagellum organization
GO005_08960	COG3334	PFAM MgtE intracellular
GO005_08965	COG3144	bacterial-type flagellum assembly
GO005_08970	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO005_08975	COG4786	Flagellar basal body rod
GO005_08980	COG1582	Flagellar protein (FlbD)
GO005_08985	COG1580	Controls the rotational direction of flagella during chemotaxis
GO005_08990	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO005_08995	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO005_08995	COG1776	CheC inhibitor of MCP methylation
GO005_09000	COG2201	protein-glutamate methylesterase activity
GO005_09005	COG3190	flagellar
GO005_09010	COG1338	Plays a role in the flagellum-specific transport system
GO005_09015	COG1987	bacterial-type flagellum assembly
GO005_09020	COG1684	flagellar biosynthetic protein fliR
GO005_09025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO005_09030	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO005_09035	COG1419	protein localization to endoplasmic reticulum
GO005_09040	COG0455	bacterial-type flagellum organization
GO005_09045	COG2201	protein-glutamate methylesterase activity
GO005_09050	COG2198	Histidine kinase
GO005_09050	COG0643	Histidine kinase
GO005_09055	COG0835	chemotaxis
GO005_09060	COG1776	CheC inhibitor of MCP methylation
GO005_09065	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GO005_09070	COG1191	sigma factor activity
GO005_09080	COG0052	Belongs to the universal ribosomal protein uS2 family
GO005_09085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GO005_09090	COG0528	UMP kinase activity
GO005_09095	COG0233	cytoplasmic translational termination
GO005_09100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO005_09105	COG4589	Belongs to the CDS family
GO005_09110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO005_09115	COG0750	zinc metalloprotease
GO005_09120	COG0442	prolyl-tRNA aminoacylation
GO005_09125	COG2176	DNA-directed DNA polymerase activity
GO005_09130	COG0779	Required for maturation of 30S ribosomal subunits
GO005_09135	COG0195	Participates in both transcription termination and antitermination
GO005_09140	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GO005_09145	COG1358	cellular component organization or biogenesis
GO005_09150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GO005_09155	COG1550	Protein conserved in bacteria
GO005_09160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GO005_09165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO005_09170	COG0196	riboflavin kinase activity
GO005_09175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GO005_09180	COG1185	polyribonucleotide nucleotidyltransferase activity
GO005_09185	COG0726	polysaccharide deacetylase
GO005_09190	COG0612	Peptidase, M16
GO005_09195	COG1873	PFAM PRC-barrel domain
GO005_09200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO005_09205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO005_09210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO005_09215	COG0527	aspartate kinase activity
GO005_09220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO005_09225	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GO005_09230	COG0740	serine-type endopeptidase activity
GO005_09240	COG1674	ftsk spoiiie
GO005_09240	COG4980	gas vesicle protein
GO005_09245	COG2188	Transcriptional regulator
GO005_09250	COG2814	Major facilitator Superfamily
GO005_09255	COG0612	Peptidase, M16
GO005_09260	COG0612	Peptidase, M16
GO005_09265	COG0300	oxidoreductase activity
GO005_09280	COG1426	Protein conserved in bacteria
GO005_09285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO005_09290	COG1058	Belongs to the CinA family
GO005_09290	COG1546	Belongs to the CinA family
GO005_09295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GO005_09300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO005_09305	COG1418	mRNA catabolic process
GO005_09310	COG1692	metallophosphoesterase
GO005_09315	COG2359	stage V sporulation protein S
GO005_09320	COG1063	alcohol dehydrogenase
GO005_09325	COG0156	8-amino-7-oxononanoate synthase activity
GO005_09330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO005_09335	COG4550	Control of competence regulator ComK, YlbF/YmcA
GO005_09345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GO005_09350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GO005_09365	COG3226	Transcriptional regulator
GO005_09370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO005_09380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO005_09385	COG3321	synthase
GO005_09390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO005_09390	COG2070	2-Nitropropane dioxygenase
GO005_09395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO005_09400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO005_09405	COG3425	synthase
GO005_09410	COG1024	Enoyl-CoA hydratase
GO005_09415	COG1024	Enoyl-CoA hydratase
GO005_09420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_09420	COG0318	PFAM AMP-dependent synthetase and ligase
GO005_09420	COG3321	synthase
GO005_09420	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_09420	COG0300	oxidoreductase activity
GO005_09425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO005_09425	COG3321	synthase
GO005_09425	COG4221	oxidoreductase activity
GO005_09425	COG0300	oxidoreductase activity
GO005_09430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO005_09430	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_09430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_09430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO005_09430	COG3321	synthase
GO005_09435	COG3321	synthase
GO005_09435	COG4221	oxidoreductase activity
GO005_09435	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_09435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_09440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO005_09440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO005_09440	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GO005_09440	COG3321	synthase
GO005_09445	COG2124	cytochrome p450
GO005_09455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO005_09460	COG1404	Belongs to the peptidase S8 family
GO005_09470	COG4195	phage-related replication protein
GO005_09475	COG1764	response to oxidative stress
GO005_09480	COG2076	Multidrug Resistance protein
GO005_09485	COG2076	Multidrug Resistance protein
GO005_09500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GO005_09505	COG1923	regulation of RNA biosynthetic process
GO005_09520	COG1780	Probably involved in ribonucleotide reductase function
GO005_09525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO005_09530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO005_09535	COG4112	unkown
GO005_09540	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO005_09545	COG0464	growth
GO005_09550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO005_09555	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GO005_09560	COG0789	Transcriptional regulator
GO005_09565	COG0174	glutamine synthetase
GO005_09585	COG4282	regulation of fungal-type cell wall biogenesis
GO005_09595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO005_09625	COG0135	phosphoribosylanthranilate isomerase activity
GO005_09630	COG2211	Major facilitator Superfamily
GO005_09635	COG3507	Belongs to the glycosyl hydrolase 43 family
GO005_09640	COG1940	carbohydrate kinase activity
GO005_09645	COG2115	Belongs to the xylose isomerase family
GO005_09650	COG1070	Carbohydrate kinase
GO005_09660	COG1525	nuclease
GO005_09665	COG2814	Major facilitator Superfamily
GO005_09670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO005_09680	COG0756	dUTP diphosphatase activity
GO005_09720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO005_09735	COG3832	glyoxalase III activity
GO005_09745	COG0697	spore germination
GO005_09750	COG0531	amino acid
GO005_09780	COG4195	phage-related replication protein
GO005_09790	COG0346	lactoylglutathione lyase activity
GO005_09795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO005_09800	COG1388	LysM domain
GO005_09805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GO005_09810	COG4224	UPF0291 protein
GO005_09815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO005_09825	COG3763	UPF0154 protein
GO005_09835	COG0785	Cytochrome C biogenesis protein
GO005_09840	COG2201	protein-glutamate methylesterase activity
GO005_09845	COG4846	Membrane protein involved in cytochrome C biogenesis
GO005_09855	COG0071	Belongs to the small heat shock protein (HSP20) family
GO005_09870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GO005_09875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_09895	COG0824	Thioesterase
GO005_09905	COG4841	protein insertion into membrane
GO005_09910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO005_09915	COG1832	CoA-binding protein
GO005_09920	COG0187	DNA topoisomerase II activity
GO005_09925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO005_09935	COG1115	amino acid carrier protein
GO005_09940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GO005_09950	COG5520	Belongs to the glycosyl hydrolase 30 family
GO005_09955	COG3507	Belongs to the glycosyl hydrolase 43 family
GO005_09960	COG2246	polysaccharide biosynthetic process
GO005_09965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO005_09970	COG0586	Pfam SNARE associated Golgi protein
GO005_09975	COG2404	hydrolase activity, acting on ester bonds
GO005_09980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO005_09985	COG1024	Enoyl-CoA hydratase
GO005_09990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO005_09995	COG0511	ligase activity, forming carbon-carbon bonds
GO005_10000	COG0439	Biotin carboxylase
GO005_10005	COG0318	PFAM AMP-dependent synthetase and ligase
GO005_10010	COG1960	acyl-CoA dehydrogenase activity
GO005_10025	COG1649	PFAM Uncharacterised BCR, COG1649
GO005_10035	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GO005_10035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_10040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_10045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_10050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_10055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_10060	COG2027	D-alanyl-D-alanine carboxypeptidase
GO005_10065	COG2017	converts alpha-aldose to the beta-anomer
GO005_10070	COG0534	Mate efflux family protein
GO005_10085	COG0582	viral genome integration into host DNA
GO005_10090	COG0166	Belongs to the GPI family
GO005_10095	COG0405	Gamma-glutamyltransferase
GO005_10100	COG0583	DNA-binding transcription factor activity
GO005_10105	COG0604	alcohol dehydrogenase
GO005_10110	COG0493	'glutamate synthase
GO005_10115	COG0067	glutamate synthase
GO005_10115	COG0069	glutamate synthase activity
GO005_10115	COG0070	glutamate synthase
GO005_10120	COG0583	DNA-binding transcription factor activity
GO005_10125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO005_10130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO005_10140	COG0300	oxidoreductase activity
GO005_10145	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GO005_10155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO005_10160	COG2814	Major facilitator Superfamily
GO005_10165	COG1070	Carbohydrate kinase
GO005_10170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO005_10175	COG0243	molybdopterin cofactor binding
GO005_10205	COG0840	transmembrane signaling receptor activity
GO005_10205	COG5278	phosphoserine phosphatase activity
GO005_10210	COG2368	4-hydroxyphenylacetate
GO005_10215	COG4305	rare lipoprotein A
GO005_10220	COG3619	membrane
GO005_10225	COG3866	Pectate lyase
GO005_10230	COG2135	peptidase activity
GO005_10240	COG2140	Oxalate decarboxylase
GO005_10265	COG2720	vancomycin resistance protein
GO005_10280	COG3739	integral membrane protein
GO005_10285	COG0583	DNA-binding transcription factor activity
GO005_10290	COG0697	spore germination
GO005_10300	COG0693	protein deglycase activity
GO005_10305	COG2367	Beta-lactamase
GO005_10330	COG0574	Belongs to the PEP-utilizing enzyme family
GO005_10330	COG3848	Pyruvate phosphate dikinase
GO005_10335	COG0726	polysaccharide deacetylase
GO005_10340	COG2314	TM2 domain
GO005_10345	COG1396	sequence-specific DNA binding
GO005_10360	COG2135	peptidase activity
GO005_10395	COG0457	Tetratricopeptide repeat
GO005_10420	COG5290	Psort location Cytoplasmic, score
GO005_10445	COG5444	nuclease activity
GO005_10450	COG4282	regulation of fungal-type cell wall biogenesis
GO005_10455	COG1231	oxidoreductase activity
GO005_10460	COG5434	Belongs to the glycosyl hydrolase 28 family
GO005_10465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO005_10470	COG0662	Cupin 2, conserved barrel domain protein
GO005_10470	COG2207	Transcriptional regulator
GO005_10475	COG0456	acetyltransferase
GO005_10480	COG1309	transcriptional regulator
GO005_10485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO005_10490	COG3708	Transcriptional regulator
GO005_10495	COG2378	regulation of single-species biofilm formation
GO005_10505	COG0640	Transcriptional regulator
GO005_10510	COG0741	lytic transglycosylase activity
GO005_10515	COG2322	membrane
GO005_10530	COG1619	proteins homologs of microcin C7 resistance protein MccF
GO005_10535	COG3239	Fatty acid desaturase
GO005_10540	COG4585	Histidine kinase
GO005_10545	COG2197	response regulator
GO005_10550	COG1388	LysM domain
GO005_10550	COG3584	3D domain protein
GO005_10555	COG0514	ATP-dependent DNA helicase (RecQ)
GO005_10565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO005_10570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO005_10585	COG0071	Belongs to the small heat shock protein (HSP20) family
GO005_10610	COG1012	belongs to the aldehyde dehydrogenase family
GO005_10615	COG1657	PFAM Prenyltransferase squalene oxidase
GO005_10620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO005_10625	COG0733	neurotransmitter:sodium symporter activity
GO005_10630	COG0385	Bile acid
GO005_10635	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO005_10640	COG0567	Dehydrogenase, E1 component
GO005_10645	COG4548	von Willebrand factor, type A
GO005_10650	COG0714	Associated with various cellular activities
GO005_10655	COG2032	superoxide dismutase activity
GO005_10660	COG1388	LysM domain
GO005_10660	COG0791	NLP P60 protein
GO005_10665	COG1819	glycosyl
GO005_10670	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GO005_10675	COG0534	Mate efflux family protein
GO005_10680	COG1366	Belongs to the anti-sigma-factor antagonist family
GO005_10685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO005_10690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO005_10700	COG2962	Rard protein
GO005_10715	COG2610	gluconate transmembrane transporter activity
GO005_10720	COG1942	4-Oxalocrotonate Tautomerase
GO005_10725	COG1733	regulation of RNA biosynthetic process
GO005_10730	COG0778	Nitroreductase
GO005_10735	COG0400	carboxylic ester hydrolase activity
GO005_10740	COG0346	lactoylglutathione lyase activity
GO005_10750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO005_10755	COG0793	Belongs to the peptidase S41A family
GO005_10755	COG3409	Peptidoglycan-binding domain 1 protein
GO005_10760	COG2226	methyltransferase
GO005_10770	COG1876	peptidase activity
GO005_10775	COG0813	purine-nucleoside phosphorylase activity
GO005_10790	COG0671	phosphoesterase, PA-phosphatase related
GO005_10810	COG4479	Belongs to the UPF0346 family
GO005_10820	COG1509	lysine 2,3-aminomutase activity
GO005_10825	COG0456	acetyltransferase
GO005_10830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO005_10835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO005_10840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GO005_10845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO005_10860	COG0456	acetyltransferase
GO005_10865	COG0463	Glycosyl transferase, family 2
GO005_10880	COG4641	Protein conserved in bacteria
GO005_10885	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GO005_10890	COG1086	Polysaccharide biosynthesis protein
GO005_10895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO005_10900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO005_10905	COG1846	Transcriptional regulator
GO005_10910	COG0534	Mate efflux family protein
GO005_10920	COG4698	Protein conserved in bacteria
GO005_10925	COG2755	lipolytic protein G-D-S-L family
GO005_10930	COG1999	signal sequence binding
GO005_10940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GO005_10945	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO005_10950	COG1272	protein, Hemolysin III
GO005_10955	COG0204	Acyl-transferase
GO005_10960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO005_10965	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GO005_10970	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO005_10980	COG2521	methyltransferase
GO005_10980	COG2136	Putative SAM-dependent methyltransferase
GO005_10990	COG0129	dihydroxy-acid dehydratase activity
GO005_10995	COG1413	lyase activity
GO005_11000	COG1418	mRNA catabolic process
GO005_11005	COG0386	Belongs to the glutathione peroxidase family
GO005_11010	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO005_11015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO005_11025	COG1278	Cold shock
GO005_11045	COG0328	RNA-DNA hybrid ribonuclease activity
GO005_11050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GO005_11055	COG0328	RNA-DNA hybrid ribonuclease activity
GO005_11065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO005_11080	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GO005_11090	COG1755	Isoprenylcysteine carboxyl methyltransferase
GO005_11095	COG3424	synthase
GO005_11100	COG2233	PERMEase
GO005_11105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO005_11110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GO005_11120	COG0800	Aldolase
GO005_11125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO005_11130	COG1609	Transcriptional regulator
GO005_11135	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GO005_11140	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_11145	COG1199	ATP-dependent helicase activity
GO005_11160	COG0116	Belongs to the methyltransferase superfamily
GO005_11175	COG4474	Belongs to the UPF0398 family
GO005_11190	COG3359	exonuclease
GO005_11195	COG1205	dead DEAH box helicase
GO005_11195	COG1111	helicase
GO005_11200	COG2190	(PTS) system
GO005_11205	COG0071	Belongs to the small heat shock protein (HSP20) family
GO005_11240	COG3331	DNA recombination
GO005_11245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO005_11245	COG4499	WXG100 protein secretion system (Wss), protein YukC
GO005_11255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO005_11260	COG3935	DnaD domain protein
GO005_11265	COG0017	Asparaginyl-tRNA synthetase
GO005_11270	COG0436	Aminotransferase
GO005_11275	COG5353	protein conserved in bacteria
GO005_11285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO005_11285	COG1199	ATP-dependent helicase activity
GO005_11290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GO005_11295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GO005_11300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO005_11305	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GO005_11305	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GO005_11310	COG0617	tRNA 3'-terminal CCA addition
GO005_11315	COG0438	transferase activity, transferring glycosyl groups
GO005_11320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO005_11325	COG1803	Methylglyoxal synthase
GO005_11330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GO005_11335	COG1694	Mazg nucleotide pyrophosphohydrolase
GO005_11340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO005_11350	COG4347	Protein of unknown function (DUF1405)
GO005_11355	COG2010	Cytochrome c
GO005_11355	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GO005_11360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GO005_11365	COG0723	plastoquinol--plastocyanin reductase activity
GO005_11375	COG5582	Belongs to the UPF0302 family
GO005_11380	COG0457	Tetratricopeptide repeat
GO005_11385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO005_11390	COG0287	Prephenate dehydrogenase
GO005_11395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO005_11400	COG0159	tryptophan synthase activity
GO005_11405	COG0133	tryptophan synthase activity
GO005_11410	COG0135	phosphoribosylanthranilate isomerase activity
GO005_11420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO005_11425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO005_11430	COG4401	Chorismate mutase type I
GO005_11435	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GO005_11440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GO005_11445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GO005_11450	COG0105	UTP biosynthetic process
GO005_11455	COG0142	geranyltranstransferase activity
GO005_11460	COG2226	methyltransferase
GO005_11465	COG0142	geranyltranstransferase activity
GO005_11475	COG0302	gtp cyclohydrolase
GO005_11480	COG0776	regulation of translation
GO005_11485	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GO005_11500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO005_11505	COG1160	GTP binding
GO005_11530	COG1304	FMN binding
GO005_11535	COG0539	negative regulation of cytoplasmic translation
GO005_11540	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GO005_11550	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GO005_11555	COG2959	enzyme of heme biosynthesis
GO005_11560	COG3773	Cell wall hydrolase
GO005_11560	COG3409	Peptidoglycan-binding domain 1 protein
GO005_11565	COG2339	peptidase activity
GO005_11570	COG0492	ferredoxin-NADP+ reductase activity
GO005_11575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO005_11580	COG4862	establishment of competence for transformation
GO005_11585	COG1408	metallophosphoesterase
GO005_11595	COG1388	LysM domain
GO005_11600	COG1266	CAAX protease self-immunity
GO005_11605	COG0514	ATP-dependent DNA helicase (RecQ)
GO005_11610	COG4955	Helix-turn-helix domain
GO005_11615	COG1141	Ferredoxin
GO005_11620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GO005_11625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO005_11630	COG0710	3-dehydroquinate dehydratase activity
GO005_11640	COG1595	DNA-templated transcription, initiation
GO005_11645	COG5002	protein histidine kinase activity
GO005_11650	COG0745	RESPONSE REGULATOR receiver
GO005_11655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO005_11660	COG1333	cytochrome c biogenesis protein
GO005_11665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_11670	COG1187	pseudouridine synthase activity
GO005_11675	COG0700	Nucleoside recognition
GO005_11680	COG2715	membrane protein required for spore maturation
GO005_11685	COG1686	Belongs to the peptidase S11 family
GO005_11695	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GO005_11700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GO005_11705	COG1547	Domain of unknown function (DUF309)
GO005_11710	COG0456	acetyltransferase
GO005_11715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GO005_11720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO005_11720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO005_11725	COG0307	riboflavin synthase, alpha
GO005_11730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO005_11730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO005_11740	COG0681	Belongs to the peptidase S26 family
GO005_11750	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GO005_11765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO005_11770	COG4086	secreted protein
GO005_11775	COG0019	diaminopimelate decarboxylase activity
GO005_11780	COG0697	spore germination
GO005_11795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO005_11815	COG1191	sigma factor activity
GO005_11820	COG2172	sigma factor antagonist activity
GO005_11825	COG1366	Belongs to the anti-sigma-factor antagonist family
GO005_11830	COG1686	Belongs to the peptidase S11 family
GO005_11835	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GO005_11840	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GO005_11845	COG4974	Belongs to the 'phage' integrase family
GO005_11855	COG0735	belongs to the Fur family
GO005_11860	COG1300	Membrane
GO005_11870	COG0281	malic enzyme
GO005_11875	COG1757	Na H antiporter
GO005_11880	COG1027	Aspartate ammonia-lyase
GO005_11885	COG0252	asparaginase activity
GO005_11890	COG1396	sequence-specific DNA binding
GO005_11895	COG1379	DNA repair
GO005_11900	COG0494	nUDIX hydrolase
GO005_11910	COG0667	Aldo Keto reductase
GO005_11920	COG1073	alpha beta
GO005_11930	COG4918	Iron-sulphur cluster biosynthesis
GO005_11935	COG0456	acetyltransferase
GO005_11935	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GO005_11940	COG2329	Antibiotic biosynthesis monooxygenase
GO005_11945	COG0456	acetyltransferase
GO005_11955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO005_11965	COG2211	Major facilitator Superfamily
GO005_11970	COG0346	lactoylglutathione lyase activity
GO005_11975	COG1072	(Pantothenic acid kinase))
GO005_11980	COG3048	D-serine ammonia-lyase activity
GO005_11985	COG0300	oxidoreductase activity
GO005_11990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO005_11995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO005_12000	COG4187	Peptidase family M20/M25/M40
GO005_12005	COG1902	pentaerythritol trinitrate reductase activity
GO005_12010	COG0596	Alpha beta hydrolase
GO005_12020	COG1234	tRNA 3'-trailer cleavage
GO005_12025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GO005_12030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO005_12035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO005_12045	COG0706	membrane insertase activity
GO005_12050	COG3361	conserved protein (COG2071)
GO005_12055	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO005_12060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO005_12065	COG0346	lactoylglutathione lyase activity
GO005_12075	COG1376	ErfK ybiS ycfS ynhG family protein
GO005_12080	COG4129	membrane
GO005_12085	COG1126	abc transporter atp-binding protein
GO005_12090	COG0765	amino acid transport
GO005_12095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO005_12105	COG1597	lipid kinase activity
GO005_12110	COG2814	Major facilitator Superfamily
GO005_12115	COG0789	Transcriptional regulator
GO005_12115	COG4978	Transcriptional regulator
GO005_12120	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO005_12125	COG0022	dehydrogenase e1 component
GO005_12130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO005_12135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO005_12140	COG3426	butyrate kinase activity
GO005_12145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO005_12150	COG0280	phosphate acetyltransferase
GO005_12155	COG3829	transcription factor binding
GO005_12155	COG3290	protein histidine kinase activity
GO005_12165	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GO005_12170	COG2079	MmgE PrpD family protein
GO005_12175	COG0372	Belongs to the citrate synthase family
GO005_12180	COG1960	acyl-CoA dehydrogenase activity
GO005_12185	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO005_12190	COG0183	Belongs to the thiolase family
GO005_12195	COG0584	glycerophosphoryl diester phosphodiesterase
GO005_12200	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO005_12215	COG1902	pentaerythritol trinitrate reductase activity
GO005_12220	COG0745	RESPONSE REGULATOR receiver
GO005_12225	COG0750	zinc metalloprotease
GO005_12230	COG0497	DNA recombination
GO005_12235	COG1438	arginine binding
GO005_12240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GO005_12245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO005_12250	COG0142	geranyltranstransferase activity
GO005_12255	COG1722	exodeoxyribonuclease VII activity
GO005_12260	COG1570	exodeoxyribonuclease VII activity
GO005_12265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GO005_12270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO005_12275	COG1302	Protein conserved in bacteria
GO005_12280	COG0439	Biotin carboxylase
GO005_12285	COG0511	ligase activity, forming carbon-carbon bonds
GO005_12325	COG3854	ATPases associated with a variety of cellular activities
GO005_12335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO005_12340	COG0006	proline dipeptidase activity
GO005_12345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GO005_12355	COG3872	metal-dependent enzyme
GO005_12365	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO005_12370	COG1321	iron dependent repressor
GO005_12375	COG0095	Lipoate-protein ligase
GO005_12380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO005_12385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO005_12390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO005_12395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO005_12400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO005_12415	COG1396	sequence-specific DNA binding
GO005_12425	COG0681	Belongs to the peptidase S26 family
GO005_12450	COG4940	Competence protein ComGF
GO005_12460	COG4970	Tfp pilus assembly protein FimT
GO005_12465	COG4537	Required for transformation and DNA binding
GO005_12470	COG1459	type II secretion system
GO005_12475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO005_12480	COG0517	IMP dehydrogenase activity
GO005_12485	COG0598	Magnesium transport protein CorA
GO005_12490	COG1253	flavin adenine dinucleotide binding
GO005_12495	COG1366	Belongs to the anti-sigma-factor antagonist family
GO005_12505	COG1393	Belongs to the ArsC family
GO005_12515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO005_12525	COG0011	TIGRFAM Protein of
GO005_12535	COG2866	Carboxypeptidase
GO005_12540	COG1368	sulfuric ester hydrolase activity
GO005_12545	COG1940	carbohydrate kinase activity
GO005_12550	COG4483	Protein conserved in bacteria
GO005_12555	COG0457	Tetratricopeptide repeat
GO005_12555	COG0705	Rhomboid family
GO005_12565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GO005_12575	COG0438	transferase activity, transferring glycosyl groups
GO005_12590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO005_12595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO005_12600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO005_12605	COG0581	inorganic phosphate transmembrane transporter activity
GO005_12610	COG0573	inorganic phosphate transmembrane transporter activity
GO005_12615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO005_12620	COG0768	penicillin binding
GO005_12625	COG0477	Major facilitator Superfamily
GO005_12630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO005_12635	COG2839	Protein conserved in bacteria
GO005_12640	COG5521	maltodextrose utilization protein MalA
GO005_12650	COG1388	LysM domain
GO005_12655	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GO005_12660	COG4709	membrane
GO005_12665	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GO005_12670	COG0735	belongs to the Fur family
GO005_12675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO005_12685	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GO005_12690	COG0513	Belongs to the DEAD box helicase family
GO005_12700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GO005_12705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO005_12710	COG2384	SAM-dependent methyltransferase
GO005_12715	COG2010	Cytochrome c
GO005_12720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO005_12725	COG0358	DNA primase activity
GO005_12730	COG1671	Belongs to the UPF0178 family
GO005_12735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GO005_12740	COG0517	IMP dehydrogenase activity
GO005_12745	COG0751	glycine-tRNA ligase activity
GO005_12750	COG0752	glycyl-tRNA synthetase alpha subunit
GO005_12755	COG1381	Involved in DNA repair and RecF pathway recombination
GO005_12765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GO005_12770	COG0295	cytidine deaminase activity
GO005_12775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO005_12780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GO005_12785	COG1480	7TM receptor with intracellular HD hydrolase
GO005_12790	COG1702	phosphate starvation-inducible protein PhoH
GO005_12795	COG0561	phosphatase activity
GO005_12810	COG4864	UPF0365 protein
GO005_12815	COG1030	water channel activity
GO005_12820	COG1610	YqeY-like protein
GO005_12830	COG1283	sodium-dependent phosphate transmembrane transporter activity
GO005_12835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO005_12840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO005_12845	COG2264	protein methyltransferase activity
GO005_12850	COG0484	heat shock protein binding
GO005_12855	COG0443	Heat shock 70 kDa protein
GO005_12860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GO005_12865	COG1420	regulation of RNA biosynthetic process
GO005_12870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO005_12875	COG0481	GTPase activity
GO005_12885	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO005_12890	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO005_12895	COG0268	Binds directly to 16S ribosomal RNA
GO005_12900	COG1466	dna polymerase III delta subunit
GO005_12915	COG2333	competence protein COMEC
GO005_12915	COG0658	competence protein
GO005_12920	COG2131	deaminase
GO005_12925	COG1596	polysaccharide export
GO005_12925	COG1555	photosystem II stabilization
GO005_12930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO005_12935	COG2226	methyltransferase
GO005_12940	COG0799	negative regulation of ribosome biogenesis
GO005_12945	COG1713	HD superfamily hydrolase involved in NAD metabolism
GO005_12950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GO005_12955	COG1534	Rna-binding protein
GO005_12960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO005_12965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GO005_12970	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GO005_12980	COG2755	lipolytic protein G-D-S-L family
GO005_12985	COG3409	Peptidoglycan-binding domain 1 protein
GO005_12985	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO005_12990	COG0398	Pfam SNARE associated Golgi protein
GO005_13005	COG3209	COG3209 Rhs family protein
GO005_13015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GO005_13020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO005_13025	COG0798	PFAM Bile acid sodium symporter
GO005_13030	COG0346	lactoylglutathione lyase activity
GO005_13035	COG0640	Transcriptional regulator
GO005_13040	COG3403	YqcI/YcgG family
GO005_13045	COG0457	Tetratricopeptide repeat
GO005_13060	COG5444	nuclease activity
GO005_13085	COG3409	Peptidoglycan-binding domain 1 protein
GO005_13085	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO005_13090	COG4824	toxin secretion phage lysis holin
GO005_13120	COG3778	Protein conserved in bacteria
GO005_13125	COG3299	homolog of phage Mu protein gp47
GO005_13130	COG3628	GPW Gp25 family protein
GO005_13140	COG4193	domain, Protein
GO005_13145	COG1652	LysM domain
GO005_13150	COG3953	SLT domain
GO005_13150	COG5280	Phage tail tape measure protein TP901
GO005_13215	COG4653	Phage capsid family
GO005_13220	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO005_13230	COG2369	cell adhesion
GO005_13235	COG5518	Phage portal protein
GO005_13240	COG1783	phage Terminase large subunit
GO005_13245	COG5484	DNA packaging
GO005_13260	COG3677	Transposase
GO005_13280	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GO005_13290	COG1484	DNA-dependent DNA replication
GO005_13295	COG3935	DnaD domain protein
GO005_13300	COG3723	Recombinational DNA repair protein, rece pathway
GO005_13305	COG5377	YqaJ viral recombinase family
GO005_13340	COG3620	sequence-specific DNA binding
GO005_13350	COG0563	adenylate kinase activity
GO005_13355	COG2856	Zn peptidase
GO005_13380	COG3223	Belongs to the PsiE family
GO005_13385	COG5002	protein histidine kinase activity
GO005_13385	COG0642	Histidine kinase
GO005_13390	COG0745	RESPONSE REGULATOR receiver
GO005_13395	COG2311	Membrane
GO005_13405	COG0454	-acetyltransferase
GO005_13410	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO005_13420	COG0730	response to heat
GO005_13425	COG0425	Belongs to the sulfur carrier protein TusA family
GO005_13430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO005_13430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO005_13440	COG0425	Belongs to the sulfur carrier protein TusA family
GO005_13440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO005_13450	COG2210	Belongs to the sulfur carrier protein TusA family
GO005_13455	COG1937	Protein conserved in bacteria
GO005_13460	COG0662	Cupin 2, conserved barrel domain protein
GO005_13470	COG4978	Transcriptional regulator
GO005_13470	COG0789	Transcriptional regulator
GO005_13475	COG2814	Major facilitator Superfamily
GO005_13480	COG0456	acetyltransferase
GO005_13485	COG1253	flavin adenine dinucleotide binding
GO005_13495	COG0697	spore germination
GO005_13500	COG0583	DNA-binding transcription factor activity
GO005_13505	COG2072	flavoprotein involved in K transport
GO005_13510	COG1230	cation diffusion facilitator family transporter
GO005_13515	COG1942	4-Oxalocrotonate Tautomerase
GO005_13520	COG0583	DNA-binding transcription factor activity
GO005_13530	COG1114	Component of the transport system for branched-chain amino acids
GO005_13535	COG1687	branched-chain amino acid
GO005_13540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GO005_13545	COG1522	sequence-specific DNA binding
GO005_13555	COG2124	cytochrome p450
GO005_13565	COG1335	isochorismatase
GO005_13575	COG2318	DinB family
GO005_13585	COG2070	2-Nitropropane dioxygenase
GO005_13590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO005_13600	COG2186	Transcriptional regulator
GO005_13615	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_13620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO005_13625	COG3959	Transketolase, thiamine diphosphate binding domain
GO005_13635	COG0789	Transcriptional regulator
GO005_13635	COG4978	Transcriptional regulator
GO005_13640	COG2315	Protein conserved in bacteria
GO005_13650	COG3443	Belongs to the bacterial solute-binding protein 9 family
GO005_13655	COG1595	DNA-templated transcription, initiation
GO005_13660	COG0667	Aldo Keto reductase
GO005_13665	COG2851	Citrate transporter
GO005_13670	COG0583	DNA-binding transcription factor activity
GO005_13675	COG2828	Protein conserved in bacteria
GO005_13680	COG3409	Peptidoglycan-binding domain 1 protein
GO005_13685	COG5566	PFAM Mor transcription activator
GO005_13690	COG0596	Alpha beta hydrolase
GO005_13695	COG4991	sh3 domain protein
GO005_13700	COG4991	sh3 domain protein
GO005_13710	COG0346	lactoylglutathione lyase activity
GO005_13720	COG5577	PFAM Coat F domain
GO005_13725	COG1063	alcohol dehydrogenase
GO005_13735	COG5577	PFAM Coat F domain
GO005_13740	COG0789	Transcriptional regulator
GO005_13750	COG1064	alcohol dehydrogenase
GO005_13755	COG0693	protein deglycase activity
GO005_13760	COG1621	beta-fructofuranosidase activity
GO005_13765	COG3716	PTS system mannose fructose sorbose family IID component
GO005_13770	COG3715	PTS system
GO005_13775	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_13780	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO005_13785	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GO005_13785	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO005_13795	COG1113	amino acid transport
GO005_13800	COG1280	lysine exporter protein (LysE YggA)
GO005_13805	COG1378	Sugar-specific transcriptional regulator TrmB
GO005_13810	COG1595	DNA-templated transcription, initiation
GO005_13820	COG2755	lipolytic protein G-D-S-L family
GO005_13820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GO005_13830	COG2124	cytochrome p450
GO005_13830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO005_13835	COG1309	transcriptional regulator
GO005_13840	COG2226	methyltransferase
GO005_13855	COG2116	formate transmembrane transporter activity
GO005_13860	COG5609	conserved protein (DUF2294)
GO005_13865	COG3383	formate dehydrogenase (NAD+) activity
GO005_13870	COG2427	Protein of unknown function (DUF1641)
GO005_13880	COG0626	cystathionine gamma-synthase activity
GO005_13885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO005_13890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO005_13895	COG2226	methyltransferase
GO005_13910	COG0768	penicillin binding
GO005_13915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO005_13920	COG0572	uridine kinase
GO005_13925	COG0826	peptidase U32
GO005_13930	COG0826	peptidase U32
GO005_13935	COG4122	O-methyltransferase activity
GO005_13940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO005_13945	COG3906	Belongs to the UPF0473 family
GO005_13950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GO005_13955	COG4472	Bacterial protein of unknown function (DUF965)
GO005_13960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO005_13965	COG0628	permease
GO005_13970	COG1126	abc transporter atp-binding protein
GO005_13975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO005_13980	COG0765	amino acid transport
GO005_13985	COG0765	amino acid transport
GO005_14000	COG3881	PFAM PRC-barrel domain
GO005_14005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO005_14010	COG0457	Tetratricopeptide repeat
GO005_14015	COG0482	sulfurtransferase activity
GO005_14020	COG1104	cysteine desulfurase activity
GO005_14025	COG1959	2 iron, 2 sulfur cluster binding
GO005_14030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO005_14035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GO005_14045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GO005_14050	COG0124	histidyl-tRNA synthetase
GO005_14060	COG3103	Sh3 type 3 domain protein
GO005_14060	COG4991	sh3 domain protein
GO005_14060	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO005_14065	COG1490	D-aminoacyl-tRNA deacylase activity
GO005_14070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO005_14075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO005_14080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO005_14080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GO005_14085	COG5416	Lipopolysaccharide assembly protein A domain
GO005_14090	COG0490	domain, Protein
GO005_14095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO005_14095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO005_14105	COG2244	polysaccharide biosynthetic process
GO005_14110	COG2323	membrane
GO005_14120	COG1862	Preprotein translocase
GO005_14125	COG0343	queuine tRNA-ribosyltransferase activity
GO005_14130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GO005_14140	COG2255	four-way junction helicase activity
GO005_14145	COG0632	four-way junction helicase activity
GO005_14155	COG2814	Major facilitator Superfamily
GO005_14160	COG0673	inositol 2-dehydrogenase activity
GO005_14165	COG2112	serine threonine protein kinase
GO005_14185	COG1115	amino acid carrier protein
GO005_14190	COG0217	transcriptional regulatory protein
GO005_14200	COG1388	LysM domain
GO005_14205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GO005_14210	COG0157	Belongs to the NadC ModD family
GO005_14215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GO005_14220	COG1104	cysteine desulfurase activity
GO005_14225	COG1827	regulation of RNA biosynthetic process
GO005_14230	COG0077	Prephenate dehydratase
GO005_14235	COG4492	Belongs to the UPF0735 family
GO005_14240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GO005_14245	COG3290	protein histidine kinase activity
GO005_14255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GO005_14260	COG2868	ribosomal protein
GO005_14265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GO005_14270	COG1994	Peptidase M50
GO005_14275	COG0739	heme binding
GO005_14280	COG2894	cell division
GO005_14285	COG0850	regulation of cytokinetic process
GO005_14290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GO005_14300	COG1077	Cell shape determining protein MreB Mrl
GO005_14305	COG2003	Belongs to the UPF0758 family
GO005_14310	COG0424	maF-like protein
GO005_14320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GO005_14325	COG0285	dihydrofolate synthase activity
GO005_14330	COG0525	valine-tRNA ligase activity
GO005_14340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO005_14345	COG1388	LysM domain
GO005_14350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO005_14355	COG0113	porphobilinogen synthase activity
GO005_14360	COG1587	Uroporphyrinogen-III synthase
GO005_14365	COG0181	hydroxymethylbilane synthase activity
GO005_14370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO005_14375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GO005_14385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GO005_14390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GO005_14395	COG0470	DNA polymerase III
GO005_14395	COG1067	ATP-dependent peptidase activity
GO005_14400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GO005_14405	COG0544	peptidyl-prolyl cis-trans isomerase activity
GO005_14410	COG0457	Tetratricopeptide repeat
GO005_14410	COG1477	protein flavinylation
GO005_14415	COG0066	3-isopropylmalate dehydratase activity
GO005_14420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GO005_14425	COG0473	3-isopropylmalate dehydrogenase activity
GO005_14430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO005_14435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GO005_14440	COG0440	acetolactate synthase activity
GO005_14445	COG0028	Belongs to the TPP enzyme family
GO005_14455	COG0454	-acetyltransferase
GO005_14460	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GO005_14470	COG0622	Phosphoesterase
GO005_14475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GO005_14480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GO005_14485	COG5401	PFAM Sporulation and spore germination
GO005_14490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO005_14495	COG1846	Transcriptional regulator
GO005_14500	COG2197	response regulator
GO005_14505	COG0824	Thioesterase
GO005_14510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GO005_14515	COG1053	succinate dehydrogenase
GO005_14520	COG2009	succinate dehydrogenase
GO005_14525	COG1719	4-vinyl reductase, 4VR
GO005_14530	COG0527	aspartate kinase activity
GO005_14535	COG0322	excinuclease ABC activity
GO005_14540	COG3118	belongs to the thioredoxin family
GO005_14545	COG3534	alpha-L-arabinofuranosidase
GO005_14550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO005_14555	COG2086	electron transfer activity
GO005_14560	COG1024	Enoyl-CoA hydratase
GO005_14565	COG1309	transcriptional regulator
GO005_14570	COG0318	PFAM AMP-dependent synthetase and ligase
GO005_14575	COG3766	membrane
GO005_14580	COG1193	negative regulation of DNA recombination
GO005_14585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO005_14585	COG1796	DNA polymerase
GO005_14590	COG1286	toxin biosynthetic process
GO005_14595	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GO005_14600	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO005_14605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO005_14605	COG0072	phenylalanine-tRNA ligase activity
GO005_14610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GO005_14620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO005_14630	COG3835	regulator
GO005_14635	COG0277	FAD linked oxidase domain protein
GO005_14640	COG0247	lactate metabolic process
GO005_14645	COG0346	lactoylglutathione lyase activity
GO005_14655	COG1966	Carbon starvation protein
GO005_14660	COG3534	alpha-L-arabinofuranosidase
GO005_14665	COG0395	ABC-type sugar transport system, permease component
GO005_14670	COG1175	transmembrane transport
GO005_14675	COG1653	transport
GO005_14680	COG0371	Dehydrogenase
GO005_14685	COG0647	UMP catabolic process
GO005_14690	COG0235	Class ii aldolase
GO005_14695	COG1069	ribulokinase activity
GO005_14700	COG2160	L-arabinose isomerase activity
GO005_14705	COG3507	Belongs to the glycosyl hydrolase 43 family
GO005_14710	COG1363	Peptidase, m42
GO005_14720	COG3326	Membrane
GO005_14725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GO005_14730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GO005_14735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GO005_14745	COG1346	cytolysis
GO005_14750	COG1380	Effector of murein hydrolase LrgA
GO005_14755	COG3279	Response regulator of the LytR AlgR family
GO005_14760	COG3275	phosphorelay sensor kinase activity
GO005_14765	COG1011	Hydrolase
GO005_14770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO005_14780	COG0398	Pfam SNARE associated Golgi protein
GO005_14785	COG1484	DNA-dependent DNA replication
GO005_14790	COG3611	Membrane attachment protein
GO005_14795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GO005_14800	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GO005_14805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO005_14810	COG1733	regulation of RNA biosynthetic process
GO005_14815	COG2814	Major facilitator Superfamily
GO005_14820	COG0656	L-ascorbic acid biosynthetic process
GO005_14825	COG0237	dephospho-CoA kinase activity
GO005_14830	COG1971	Probably functions as a manganese efflux pump
GO005_14835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO005_14840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO005_14840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO005_14845	COG5002	protein histidine kinase activity
GO005_14850	COG0745	RESPONSE REGULATOR receiver
GO005_14855	COG0039	L-malate dehydrogenase activity
GO005_14860	COG0538	isocitrate dehydrogenase activity
GO005_14865	COG0372	Belongs to the citrate synthase family
GO005_14870	COG2707	UPF0756 membrane protein
GO005_14875	COG0628	permease
GO005_14880	COG3030	protein affecting phage T7 exclusion by the F plasmid
GO005_14885	COG0469	pyruvate kinase activity
GO005_14890	COG0205	6-phosphofructokinase activity
GO005_14895	COG0825	malonyl-CoA metabolic process
GO005_14900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GO005_14905	COG0281	malic enzyme
GO005_14910	COG0587	DNA-directed DNA polymerase activity
GO005_14930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GO005_14940	COG4109	DRTGG domain
GO005_14945	COG0730	response to heat
GO005_14950	COG1473	amidohydrolase
GO005_14955	COG0196	riboflavin kinase activity
GO005_14960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO005_14965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO005_14970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO005_14975	COG1126	abc transporter atp-binding protein
GO005_14980	COG0765	amino acid transport
GO005_14985	COG0765	amino acid transport
GO005_14990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO005_14995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO005_15000	COG0454	-acetyltransferase
GO005_15005	COG0583	DNA-binding transcription factor activity
GO005_15010	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GO005_15015	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_15025	COG0165	Argininosuccinate lyase
GO005_15030	COG0137	argininosuccinate synthase activity
GO005_15035	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO005_15040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO005_15050	COG0827	DNA restriction-modification system
GO005_15055	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GO005_15060	COG3874	Sporulation protein YtfJ
GO005_15070	COG1714	RDD family
GO005_15075	COG0616	signal peptide processing
GO005_15080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO005_15085	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GO005_15090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO005_15100	COG0301	tRNA thio-modification
GO005_15105	COG1104	cysteine desulfurase activity
GO005_15110	COG1114	Component of the transport system for branched-chain amino acids
GO005_15115	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GO005_15120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO005_15125	COG1309	transcriptional regulator
GO005_15130	COG1956	GAF domain-containing protein
GO005_15135	COG2199	diguanylate cyclase activity
GO005_15135	COG2203	Gaf domain
GO005_15145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GO005_15150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO005_15155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO005_15160	COG0454	-acetyltransferase
GO005_15165	COG0517	IMP dehydrogenase activity
GO005_15170	COG0123	including yeast histone deacetylase and acetoin utilization protein
GO005_15175	COG1360	Flagellar Motor Protein
GO005_15180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO005_15185	COG1609	Transcriptional regulator
GO005_15190	COG1605	Chorismate mutase
GO005_15190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GO005_15195	COG3118	belongs to the thioredoxin family
GO005_15200	COG4980	gas vesicle protein
GO005_15205	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GO005_15210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO005_15215	COG1674	ftsk spoiiie
GO005_15220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO005_15225	COG4848	Belongs to the UPF0354 family
GO005_15230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_15245	COG1363	Peptidase, m42
GO005_15250	COG5584	Small secreted protein
GO005_15255	COG0281	malic enzyme
GO005_15260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO005_15265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GO005_15275	COG0510	thiamine kinase activity
GO005_15280	COG1523	belongs to the glycosyl hydrolase 13 family
GO005_15285	COG1597	lipid kinase activity
GO005_15295	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GO005_15300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO005_15305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO005_15310	COG2252	PERMEase
GO005_15315	COG4473	ABC transporter
GO005_15320	COG1131	(ABC) transporter
GO005_15325	COG1349	DNA-binding transcription factor activity
GO005_15330	COG1187	pseudouridine synthase activity
GO005_15335	COG2244	polysaccharide biosynthetic process
GO005_15340	COG2081	HI0933 family
GO005_15345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO005_15355	COG5578	integral membrane protein
GO005_15360	COG0673	inositol 2-dehydrogenase activity
GO005_15365	COG1653	transport
GO005_15370	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GO005_15375	COG4209	transmembrane transport
GO005_15380	COG2207	Transcriptional regulator
GO005_15385	COG1653	transport
GO005_15390	COG0395	ABC-type sugar transport system, permease component
GO005_15395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO005_15400	COG2124	cytochrome p450
GO005_15405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GO005_15415	COG0156	8-amino-7-oxononanoate synthase activity
GO005_15420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO005_15430	COG1073	alpha beta
GO005_15435	COG1609	Transcriptional regulator
GO005_15440	COG1653	transport
GO005_15445	COG1175	transmembrane transport
GO005_15450	COG0395	ABC-type sugar transport system, permease component
GO005_15455	COG1486	melibiose metabolic process
GO005_15460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO005_15465	COG0495	leucyl-tRNA aminoacylation
GO005_15475	COG1366	Belongs to the anti-sigma-factor antagonist family
GO005_15475	COG2202	Pas domain
GO005_15480	COG2814	Major facilitator Superfamily
GO005_15485	COG2433	Pfam Transposase IS66
GO005_15490	COG0577	efflux transmembrane transporter activity
GO005_15495	COG1136	(ABC) transporter
GO005_15500	COG2205	protein histidine kinase activity
GO005_15505	COG0745	RESPONSE REGULATOR receiver
GO005_15510	COG0577	efflux transmembrane transporter activity
GO005_15515	COG1136	(ABC) transporter
GO005_15530	COG1131	(ABC) transporter
GO005_15535	COG1725	Transcriptional regulator
GO005_15550	COG1242	4 iron, 4 sulfur cluster binding
GO005_15555	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GO005_15565	COG2267	carboxylic ester hydrolase activity
GO005_15570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GO005_15575	COG1113	amino acid transport
GO005_15580	COG0367	asparagine synthase
GO005_15585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GO005_15590	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GO005_15600	COG1506	peptidase
GO005_15605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO005_15610	COG1116	anion transmembrane transporter activity
GO005_15615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO005_15620	COG0494	nUDIX hydrolase
GO005_15625	COG4824	toxin secretion phage lysis holin
GO005_15630	COG0783	Belongs to the Dps family
GO005_15645	COG1854	S-ribosylhomocysteine lyase activity
GO005_15650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GO005_15655	COG0288	reversible hydration of carbon dioxide
GO005_15660	COG0254	rRNA binding
GO005_15665	COG1271	oxidase subunit
GO005_15670	COG1294	oxidase, subunit
GO005_15680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO005_15685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO005_15685	COG1321	iron dependent repressor
GO005_15690	COG1121	(ABC) transporter
GO005_15695	COG0803	Belongs to the bacterial solute-binding protein 9 family
GO005_15700	COG4948	Mandelate Racemase Muconate Lactonizing
GO005_15705	COG0318	PFAM AMP-dependent synthetase and ligase
GO005_15710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO005_15715	COG0596	Alpha beta hydrolase
GO005_15720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GO005_15725	COG1169	isochorismate synthase
GO005_15730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO005_15735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO005_15740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GO005_15745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO005_15750	COG0438	transferase activity, transferring glycosyl groups
GO005_15760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO005_15765	COG0438	transferase activity, transferring glycosyl groups
GO005_15770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO005_15775	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GO005_15780	COG0058	SHG alpha-glucan phosphorylase activity
GO005_15785	COG0297	glycogen (starch) synthase activity
GO005_15790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO005_15795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO005_15800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GO005_15925	COG3859	Proton-coupled thiamine transporter YuaJ
GO005_15930	COG1247	-acetyltransferase
GO005_15935	COG2268	Band 7 protein
GO005_15940	COG1585	Membrane protein implicated in regulation of membrane protease activity
GO005_15945	COG2318	DinB family
GO005_15955	COG1454	alcohol dehydrogenase
GO005_15960	COG1012	belongs to the aldehyde dehydrogenase family
GO005_15965	COG1510	regulation of RNA biosynthetic process
GO005_15975	COG0569	domain protein
GO005_15980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO005_15985	COG4682	membrane
GO005_15990	COG1705	Flagellar rod assembly protein muramidase FlgJ
GO005_15995	COG0477	Major facilitator Superfamily
GO005_16000	COG5553	Cysteine dioxygenase type I
GO005_16010	COG1968	undecaprenyl-diphosphatase activity
GO005_16015	COG0628	permease
GO005_16020	COG0673	inositol 2-dehydrogenase activity
GO005_16025	COG4806	L-rhamnose isomerase
GO005_16030	COG3254	rhamnose metabolic process
GO005_16035	COG1070	Carbohydrate kinase
GO005_16040	COG1349	DNA-binding transcription factor activity
GO005_16045	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_16045	COG3347	Dehydrogenase
GO005_16050	COG0840	transmembrane signaling receptor activity
GO005_16055	COG0840	transmembrane signaling receptor activity
GO005_16060	COG0840	transmembrane signaling receptor activity
GO005_16065	COG0840	transmembrane signaling receptor activity
GO005_16080	COG0432	Pfam Uncharacterised protein family UPF0047
GO005_16090	COG0366	Alpha amylase catalytic
GO005_16095	COG1253	flavin adenine dinucleotide binding
GO005_16100	COG2738	Putative neutral zinc metallopeptidase
GO005_16115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO005_16130	COG0166	Belongs to the GPI family
GO005_16135	COG1979	alcohol dehydrogenase
GO005_16140	COG1979	alcohol dehydrogenase
GO005_16145	COG2155	Conserved Protein
GO005_16150	COG1098	S1 RNA binding domain
GO005_16155	COG0436	Aminotransferase
GO005_16160	COG1522	sequence-specific DNA binding
GO005_16165	COG2267	carboxylic ester hydrolase activity
GO005_16175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GO005_16180	COG2205	protein histidine kinase activity
GO005_16190	COG5018	Exonuclease
GO005_16200	COG2814	Major facilitator Superfamily
GO005_16205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO005_16210	COG3011	Protein conserved in bacteria
GO005_16220	COG3290	protein histidine kinase activity
GO005_16225	COG4565	transcriptional regulatory protein
GO005_16230	COG1744	ABC transporter substrate-binding protein PnrA-like
GO005_16235	COG3845	ABC transporter
GO005_16240	COG4603	Belongs to the binding-protein-dependent transport system permease family
GO005_16245	COG1079	Belongs to the binding-protein-dependent transport system permease family
GO005_16250	COG3493	citrate carrier protein
GO005_16260	COG2111	Na H antiporter
GO005_16260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO005_16265	COG2111	Na H antiporter
GO005_16270	COG1006	Multisubunit Na H antiporter MnhC subunit
GO005_16275	COG0651	ATP synthesis coupled electron transport
GO005_16280	COG1863	multisubunit Na H antiporter MnhE subunit
GO005_16285	COG2212	antiporter activity
GO005_16290	COG1320	monovalent cation:proton antiporter activity
GO005_16295	COG2050	protein possibly involved in aromatic compounds catabolism
GO005_16300	COG2197	response regulator
GO005_16305	COG4585	Histidine kinase
GO005_16315	COG0142	geranyltranstransferase activity
GO005_16335	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GO005_16340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GO005_16345	COG1335	isochorismatase
GO005_16350	COG5506	Protein of unknown function (DUF1694)
GO005_16365	COG0628	permease
GO005_16380	COG1418	mRNA catabolic process
GO005_16385	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_16395	COG1511	domain protein
GO005_16400	COG1674	ftsk spoiiie
GO005_16400	COG0433	COG0433 Predicted ATPase
GO005_16405	COG4499	WXG100 protein secretion system (Wss), protein YukC
GO005_16410	COG5417	Belongs to the EsaB family
GO005_16415	COG4842	Belongs to the WXG100 family
GO005_16420	COG2508	Transcriptional regulator
GO005_16420	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GO005_16425	COG0686	Belongs to the AlaDH PNT family
GO005_16430	COG5634	Uncharacterized conserved protein (DUF2278)
GO005_16435	COG3251	PFAM MbtH domain protein
GO005_16440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_16445	COG3433	isochorismatase activity
GO005_16445	COG1535	isochorismatase
GO005_16450	COG1021	2,3-dihydroxybenzoate-AMP ligase
GO005_16455	COG1169	isochorismate synthase
GO005_16460	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_16465	COG2819	hydrolase of the alpha beta superfamily
GO005_16470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GO005_16475	COG1268	BioY protein
GO005_16480	COG2056	Na+-H+ antiporter family
GO005_16485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO005_16490	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GO005_16495	COG3584	3D domain protein
GO005_16510	COG1252	NADH dehydrogenase
GO005_16515	COG0492	ferredoxin-NADP+ reductase activity
GO005_16525	COG0516	GMP reductase activity
GO005_16530	COG2808	Putative FMN-binding domain
GO005_16535	COG0456	acetyltransferase
GO005_16540	COG0316	Belongs to the HesB IscA family
GO005_16545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GO005_16550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO005_16555	COG4844	belongs to the
GO005_16560	COG1252	NADH dehydrogenase
GO005_16565	COG4837	Protein of unknown function (DUF1462)
GO005_16570	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GO005_16575	COG0823	Involved in the tonB-independent uptake of proteins
GO005_16575	COG1506	peptidase
GO005_16575	COG4946	Tricorn protease homolog
GO005_16580	COG0083	homoserine kinase activity
GO005_16585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GO005_16590	COG0460	homoserine dehydrogenase
GO005_16595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO005_16600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO005_16605	COG0647	UMP catabolic process
GO005_16610	COG2445	Protein of unknown function DUF86
GO005_16615	COG4470	Protein conserved in bacteria
GO005_16625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO005_16630	COG0739	heme binding
GO005_16640	COG3377	Domain of unknown function (DUF1805)
GO005_16645	COG0737	Belongs to the 5'-nucleotidase family
GO005_16650	COG0730	response to heat
GO005_16655	COG1801	Protein of unknown function DUF72
GO005_16665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO005_16670	COG2508	Transcriptional regulator
GO005_16675	COG2233	PERMEase
GO005_16680	COG2233	PERMEase
GO005_16685	COG3648	Uricase
GO005_16685	COG3195	allantoin biosynthetic process
GO005_16690	COG2351	hydroxyisourate hydrolase activity
GO005_16700	COG2080	2 iron, 2 sulfur cluster binding
GO005_16705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GO005_16710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GO005_16715	COG2068	MobA-Related Protein
GO005_16720	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GO005_16725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO005_16730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO005_16740	COG2356	endonuclease I
GO005_16745	COG3842	ATPase activity
GO005_16750	COG2188	Transcriptional regulator
GO005_16755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO005_16760	COG0395	ABC-type sugar transport system, permease component
GO005_16765	COG1175	transmembrane transport
GO005_16770	COG1653	transport
GO005_16775	COG2222	sugar isomerase
GO005_16780	COG0322	excinuclease ABC activity
GO005_16785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO005_16800	COG0346	lactoylglutathione lyase activity
GO005_16805	COG0640	Transcriptional regulator
GO005_16810	COG0719	Fe-S assembly protein
GO005_16815	COG0822	iron-sulfur transferase activity
GO005_16820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO005_16825	COG0719	Fe-S assembly protein
GO005_16830	COG0396	ATPase activity
GO005_16840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO005_16845	COG1464	Belongs to the NlpA lipoprotein family
GO005_16850	COG2011	ABC-type metal ion transport system permease component
GO005_16855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO005_16865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO005_16870	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GO005_16880	COG0509	glycine decarboxylation via glycine cleavage system
GO005_16885	COG1393	Belongs to the ArsC family
GO005_16890	COG1960	acyl-CoA dehydrogenase activity
GO005_16895	COG0183	Belongs to the thiolase family
GO005_16900	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO005_16900	COG1024	Enoyl-CoA hydratase
GO005_16910	COG0506	proline dehydrogenase activity
GO005_16920	COG5577	PFAM Coat F domain
GO005_16925	COG1846	Transcriptional regulator
GO005_16930	COG0477	Major facilitator Superfamily
GO005_16935	COG1942	4-Oxalocrotonate Tautomerase
GO005_16940	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_16945	COG0583	DNA-binding transcription factor activity
GO005_16955	COG1120	ATPase activity
GO005_16970	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_16975	COG0783	Belongs to the Dps family
GO005_16980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO005_16985	COG0745	RESPONSE REGULATOR receiver
GO005_16990	COG2205	protein histidine kinase activity
GO005_16990	COG2770	Histidine kinase
GO005_17000	COG1309	transcriptional regulator
GO005_17005	COG0114	fumarate hydratase activity
GO005_17015	COG0697	spore germination
GO005_17020	COG0814	amino acid
GO005_17030	COG2197	response regulator
GO005_17035	COG4585	Histidine kinase
GO005_17040	COG4758	membrane
GO005_17045	COG3595	metallopeptidase activity
GO005_17050	COG1842	Phage shock protein A
GO005_17055	COG4758	membrane
GO005_17060	COG2814	Major facilitator Superfamily
GO005_17065	COG2096	Adenosyltransferase
GO005_17070	COG1120	ATPase activity
GO005_17075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_17080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO005_17085	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_17090	COG3386	PFAM SMP-30 Gluconolaconase
GO005_17095	COG2205	protein histidine kinase activity
GO005_17100	COG0745	RESPONSE REGULATOR receiver
GO005_17110	COG1191	sigma factor activity
GO005_17120	COG2140	Oxalate decarboxylase
GO005_17130	COG0577	efflux transmembrane transporter activity
GO005_17135	COG1136	(ABC) transporter
GO005_17140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO005_17145	COG1120	ATPase activity
GO005_17150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_17155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO005_17160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO005_17165	COG0531	amino acid
GO005_17175	COG1988	membrane-bound metal-dependent
GO005_17180	COG1368	sulfuric ester hydrolase activity
GO005_17185	COG1910	domain protein
GO005_17190	COG0725	ABC transporter, periplasmic molybdate-binding protein
GO005_17195	COG4149	molybdate abc transporter
GO005_17200	COG0656	L-ascorbic acid biosynthetic process
GO005_17210	COG0025	NhaP-type Na H and K H
GO005_17215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO005_17220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO005_17225	COG3973	AAA domain
GO005_17235	COG2860	membrane
GO005_17240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO005_17245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO005_17250	COG2217	Heavy metal translocating P-type atpase
GO005_17255	COG2217	Heavy metal translocating P-type atpase
GO005_17260	COG2608	mercury ion transmembrane transporter activity
GO005_17265	COG1937	Protein conserved in bacteria
GO005_17270	COG0673	inositol 2-dehydrogenase activity
GO005_17275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO005_17280	COG1289	transmembrane transporter activity
GO005_17290	COG2076	Multidrug Resistance protein
GO005_17295	COG1309	transcriptional regulator
GO005_17300	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_17310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GO005_17315	COG0557	exoribonuclease II activity
GO005_17320	COG1647	Serine aminopeptidase, S33
GO005_17325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO005_17335	COG1476	TRANSCRIPTIONal
GO005_17340	COG1396	sequence-specific DNA binding
GO005_17345	COG1396	sequence-specific DNA binding
GO005_17350	COG1733	regulation of RNA biosynthetic process
GO005_17355	COG0840	transmembrane signaling receptor activity
GO005_17360	COG1174	glycine betaine transport
GO005_17365	COG1732	Glycine betaine
GO005_17370	COG1174	glycine betaine transport
GO005_17375	COG0517	IMP dehydrogenase activity
GO005_17375	COG1125	glycine betaine transport
GO005_17380	COG1510	regulation of RNA biosynthetic process
GO005_17400	COG5658	integral membrane protein
GO005_17405	COG0640	Transcriptional regulator
GO005_17410	COG1174	glycine betaine transport
GO005_17415	COG1732	Glycine betaine
GO005_17420	COG1174	glycine betaine transport
GO005_17425	COG0517	IMP dehydrogenase activity
GO005_17425	COG1125	glycine betaine transport
GO005_17430	COG1510	regulation of RNA biosynthetic process
GO005_17435	COG2095	MarC family integral membrane protein
GO005_17445	COG3064	Membrane
GO005_17450	COG4640	response to antibiotic
GO005_17455	COG0456	acetyltransferase
GO005_17460	COG0148	phosphopyruvate hydratase activity
GO005_17465	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GO005_17470	COG0149	triose-phosphate isomerase activity
GO005_17475	COG0126	phosphoglycerate kinase activity
GO005_17480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO005_17485	COG2390	Transcriptional regulator
GO005_17490	COG2814	Major facilitator Superfamily
GO005_17495	COG1609	Transcriptional regulator
GO005_17500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO005_17505	COG0583	DNA-binding transcription factor activity
GO005_17510	COG0697	spore germination
GO005_17515	COG1113	amino acid transport
GO005_17520	COG3858	chitin binding
GO005_17525	COG1556	Lactate utilization protein
GO005_17530	COG1139	Iron-sulfur cluster binding protein
GO005_17535	COG0247	lactate metabolic process
GO005_17540	COG2197	response regulator
GO005_17545	COG4585	Histidine kinase
GO005_17550	COG0842	Transport permease protein
GO005_17555	COG1131	(ABC) transporter
GO005_17560	COG0596	Alpha beta hydrolase
GO005_17565	COG2208	phosphoserine phosphatase activity
GO005_17570	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GO005_17575	COG1874	Beta-galactosidase
GO005_17580	COG3833	ABC-type maltose transport systems, permease component
GO005_17585	COG1175	transmembrane transport
GO005_17590	COG2182	Extracellular solute-binding protein
GO005_17595	COG1609	Transcriptional regulator
GO005_17600	COG2186	Transcriptional regulator
GO005_17605	COG1620	l-lactate permease
GO005_17610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GO005_17620	COG5039	Polysaccharide pyruvyl transferase
GO005_17625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO005_17630	COG0110	maltose O-acetyltransferase activity
GO005_17635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO005_17640	COG2244	polysaccharide biosynthetic process
GO005_17645	COG1216	Glycosyl transferase, family 2
GO005_17650	COG5039	Polysaccharide pyruvyl transferase
GO005_17655	COG1216	Glycosyl transferase, family 2
GO005_17665	COG0438	transferase activity, transferring glycosyl groups
GO005_17670	COG1215	transferase activity, transferring glycosyl groups
GO005_17675	COG0438	transferase activity, transferring glycosyl groups
GO005_17680	COG1086	Polysaccharide biosynthesis protein
GO005_17685	COG0489	protein tyrosine kinase activity
GO005_17690	COG3944	biosynthesis protein
GO005_17695	COG1396	sequence-specific DNA binding
GO005_17700	COG2272	Belongs to the type-B carboxylesterase lipase family
GO005_17710	COG3479	Phenolic acid decarboxylase
GO005_17720	COG1794	racemase activity, acting on amino acids and derivatives
GO005_17725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO005_17730	COG1621	beta-fructofuranosidase activity
GO005_17735	COG1621	beta-fructofuranosidase activity
GO005_17740	COG0531	amino acid
GO005_17745	COG1309	transcriptional regulator
GO005_17750	COG2076	Multidrug Resistance protein
GO005_17755	COG2076	Multidrug Resistance protein
GO005_17765	COG0277	FAD linked oxidase domain protein
GO005_17770	COG3621	Patatin-like phospholipase
GO005_17780	COG0740	serine-type endopeptidase activity
GO005_17785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO005_17790	COG0366	Alpha amylase catalytic
GO005_17795	COG1554	hydrolase, family 65, central catalytic
GO005_17800	COG5521	maltodextrose utilization protein MalA
GO005_17805	COG3833	ABC-type maltose transport systems, permease component
GO005_17810	COG1175	transmembrane transport
GO005_17815	COG2182	Extracellular solute-binding protein
GO005_17820	COG0366	Alpha amylase catalytic
GO005_17825	COG1609	Transcriptional regulator
GO005_17830	COG1611	Belongs to the LOG family
GO005_17835	COG1694	Mazg nucleotide pyrophosphohydrolase
GO005_17840	COG0659	secondary active sulfate transmembrane transporter activity
GO005_17845	COG0288	reversible hydration of carbon dioxide
GO005_17850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO005_17855	COG0577	efflux transmembrane transporter activity
GO005_17860	COG1136	(ABC) transporter
GO005_17865	COG5002	protein histidine kinase activity
GO005_17870	COG0745	RESPONSE REGULATOR receiver
GO005_17880	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GO005_17885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO005_17890	COG1481	regulation of sporulation
GO005_17895	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GO005_17900	COG1660	Displays ATPase and GTPase activities
GO005_17905	COG1051	belongs to the nudix hydrolase family
GO005_17910	COG0492	ferredoxin-NADP+ reductase activity
GO005_17915	COG3883	PFAM NLP P60 protein
GO005_17915	COG0791	NLP P60 protein
GO005_17920	COG0457	Tetratricopeptide repeat
GO005_17925	COG1132	(ABC) transporter
GO005_17945	COG0140	phosphoribosyl-ATP diphosphatase activity
GO005_17945	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO005_17950	COG0107	imidazoleglycerol-phosphate synthase activity
GO005_17955	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GO005_17960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO005_17965	COG0131	Imidazoleglycerol-phosphate dehydratase
GO005_17970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO005_17975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO005_17980	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GO005_17985	COG4990	cell redox homeostasis
GO005_17990	COG5297	Belongs to the glycosyl hydrolase family 6
GO005_17995	COG0110	maltose O-acetyltransferase activity
GO005_18000	COG0546	phosphoglycolate phosphatase activity
GO005_18005	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GO005_18010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GO005_18015	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GO005_18020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GO005_18025	COG0363	glucosamine-6-phosphate deaminase activity
GO005_18030	COG2188	Transcriptional regulator
GO005_18035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GO005_18040	COG1846	Transcriptional regulator
GO005_18045	COG2124	cytochrome p450
GO005_18055	COG1846	Transcriptional regulator
GO005_18060	COG2814	Major facilitator Superfamily
GO005_18065	COG1950	PFAM Membrane protein of
GO005_18070	COG1983	PspC domain protein
GO005_18075	COG3595	metallopeptidase activity
GO005_18095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GO005_18100	COG0556	nucleotide-excision repair
GO005_18105	COG4897	Protein conserved in bacteria
GO005_18110	COG3848	Pyruvate phosphate dikinase
GO005_18110	COG0574	Belongs to the PEP-utilizing enzyme family
GO005_18115	COG1309	transcriptional regulator
GO005_18120	COG2814	Major facilitator Superfamily
GO005_18125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO005_18135	COG3409	Peptidoglycan-binding domain 1 protein
GO005_18135	COG0793	Belongs to the peptidase S41A family
GO005_18140	COG2177	Part of the ABC transporter FtsEX involved in
GO005_18145	COG2884	Cell division ATP-binding protein ftsE
GO005_18150	COG2010	Cytochrome c
GO005_18155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO005_18165	COG0653	protein targeting
GO005_18170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO005_18185	COG1516	flagellar protein fliS
GO005_18190	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GO005_18195	COG1334	flagellar protein FlaG
GO005_18200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO005_18205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GO005_18210	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GO005_18220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO005_18225	COG1256	bacterial-type flagellum assembly
GO005_18225	COG4786	Flagellar basal body rod
GO005_18230	COG3418	PFAM FlgN family protein
GO005_18235	COG2747	anti-sigma28 factor FlgM
GO005_18245	COG1040	competence protein
GO005_18255	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GO005_18260	COG1307	EDD domain protein, DegV family
GO005_18265	COG2197	response regulator
GO005_18270	COG4585	Histidine kinase
GO005_18275	COG1739	Uncharacterized protein family UPF0029
GO005_18280	COG1316	TRANSCRIPTIONal
GO005_18285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO005_18290	COG0438	transferase activity, transferring glycosyl groups
GO005_18295	COG1215	transferase activity, transferring glycosyl groups
GO005_18300	COG3206	protein involved in exopolysaccharide biosynthesis
GO005_18305	COG3307	-O-antigen
GO005_18310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GO005_18315	COG0438	transferase activity, transferring glycosyl groups
GO005_18315	COG0297	glycogen (starch) synthase activity
GO005_18320	COG2244	polysaccharide biosynthetic process
GO005_18330	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO005_18330	COG2247	cell wall binding repeat
GO005_18335	COG2385	sporulation resulting in formation of a cellular spore
GO005_18335	COG2247	cell wall binding repeat
GO005_18345	COG1316	TRANSCRIPTIONal
GO005_18350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GO005_18355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO005_18365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO005_18365	COG1215	transferase activity, transferring glycosyl groups
GO005_18370	COG0463	Glycosyl transferase, family 2
GO005_18380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO005_18390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO005_18395	COG1134	teichoic acid transport
GO005_18400	COG1682	transport, permease protein
GO005_18405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO005_18410	COG0438	transferase activity, transferring glycosyl groups
GO005_18415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GO005_18420	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GO005_18425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO005_18435	COG4193	domain, Protein
GO005_18440	COG1482	cell wall glycoprotein biosynthetic process
GO005_18445	COG0697	spore germination
GO005_18450	COG0814	amino acid
GO005_18460	COG2814	Major facilitator Superfamily
GO005_18465	COG1316	TRANSCRIPTIONal
GO005_18470	COG0561	phosphatase activity
GO005_18475	COG0791	NLP P60 protein
GO005_18485	COG2843	Capsule synthesis protein
GO005_18495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO005_18500	COG1609	Transcriptional regulator
GO005_18505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO005_18510	COG1869	D-ribose catabolic process
GO005_18515	COG1129	ABC transporter
GO005_18520	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO005_18525	COG1879	ABC-type sugar transport system periplasmic component
GO005_18530	COG3103	Sh3 type 3 domain protein
GO005_18540	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO005_18545	COG3527	Alpha-acetolactate decarboxylase
GO005_18550	COG0028	Belongs to the TPP enzyme family
GO005_18555	COG0583	DNA-binding transcription factor activity
GO005_18560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GO005_18575	COG5337	Spore coat protein CotH
GO005_18585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO005_18595	COG0405	Gamma-glutamyltransferase
GO005_18600	COG1522	sequence-specific DNA binding
GO005_18605	COG2059	Chromate
GO005_18610	COG2059	Chromate
GO005_18620	COG0655	NAD(P)H dehydrogenase (quinone) activity
GO005_18625	COG0583	DNA-binding transcription factor activity
GO005_18640	COG5444	nuclease activity
GO005_18660	COG3878	Protein conserved in bacteria
GO005_18665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GO005_18670	COG4464	protein tyrosine phosphatase activity
GO005_18675	COG0489	protein tyrosine kinase activity
GO005_18680	COG3944	biosynthesis protein
GO005_18690	COG4715	Zinc finger, swim domain protein
GO005_18695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO005_18700	COG0561	phosphatase activity
GO005_18705	COG1349	DNA-binding transcription factor activity
GO005_18710	COG0629	single-stranded DNA binding
GO005_18725	COG3764	Sortase (surface protein transpeptidase)
GO005_18730	COG2972	Histidine kinase
GO005_18730	COG0745	RESPONSE REGULATOR receiver
GO005_18735	COG1970	mechanosensitive ion channel activity
GO005_18740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO005_18745	COG0457	Tetratricopeptide repeat
GO005_18750	COG4786	Flagellar basal body rod
GO005_18755	COG4786	Flagellar basal body rod
GO005_18760	COG1077	Cell shape determining protein MreB Mrl
GO005_18765	COG1609	Transcriptional regulator
GO005_18775	COG1846	Transcriptional regulator
GO005_18780	COG2814	Major facilitator Superfamily
GO005_18785	COG3420	alginic acid biosynthetic process
GO005_18790	COG1953	Uracil, thiamine, allantoin
GO005_18795	COG0477	Major facilitator Superfamily
GO005_18800	COG1335	isochorismatase
GO005_18810	COG0004	ammonium transporteR
GO005_18815	COG0347	Belongs to the P(II) protein family
GO005_18820	COG0671	phosphoesterase, PA-phosphatase related
GO005_18830	COG0739	heme binding
GO005_18835	COG1247	-acetyltransferase
GO005_18855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO005_18860	COG0789	Transcriptional regulator
GO005_18870	COG2910	NAD(P)H-binding
GO005_18875	COG1959	2 iron, 2 sulfur cluster binding
GO005_18880	COG0804	urea catabolic process
GO005_18885	COG0832	Belongs to the urease beta subunit family
GO005_18890	COG0831	urea catabolic process
GO005_18905	COG3237	CsbD-like
GO005_18910	COG1994	Peptidase M50
GO005_18915	COG0457	Tetratricopeptide repeat
GO005_18920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GO005_18925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO005_18935	COG2304	oxidoreductase activity
GO005_18945	COG2304	oxidoreductase activity
GO005_18950	COG2385	sporulation resulting in formation of a cellular spore
GO005_18955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO005_18965	COG4836	Membrane
GO005_18975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO005_18980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GO005_18985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO005_18990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GO005_18995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GO005_19000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO005_19010	COG0356	it plays a direct role in the translocation of protons across the membrane
GO005_19020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GO005_19025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GO005_19030	COG4475	Protein of unknown function (DUF436)
GO005_19035	COG0698	ribose 5-phosphate isomerase
GO005_19040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO005_19045	COG1971	Probably functions as a manganese efflux pump
GO005_19050	COG0009	L-threonylcarbamoyladenylate synthase
GO005_19055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO005_19075	COG2890	protein-(glutamine-N5) methyltransferase activity
GO005_19080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GO005_19085	COG0346	lactoylglutathione lyase activity
GO005_19090	COG0789	Transcriptional regulator
GO005_19095	COG0679	Auxin Efflux Carrier
GO005_19100	COG0281	malic enzyme
GO005_19105	COG1435	thymidine kinase activity
GO005_19125	COG1494	fructose-1,6-bisphosphatase
GO005_19130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO005_19135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GO005_19140	COG0191	fructose-bisphosphate aldolase activity
GO005_19145	COG2204	response regulator
GO005_19150	COG4821	SIS domain
GO005_19155	COG0504	CTP synthase activity
GO005_19165	COG1960	acyl-CoA dehydrogenase activity
GO005_19170	COG2181	nitrate reductase activity
GO005_19170	COG0247	lactate metabolic process
GO005_19175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO005_19180	COG4294	response to UV
GO005_19190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO005_19195	COG1132	(ABC) transporter
GO005_19200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO005_19205	COG2181	nitrate reductase activity
GO005_19210	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GO005_19215	COG1140	nitrate reductase beta subunit
GO005_19220	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GO005_19225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO005_19235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO005_19240	COG2223	nitrite transmembrane transporter activity
GO005_19245	COG0018	arginyl-trna synthetase
GO005_19250	COG4506	Protein conserved in bacteria
GO005_19265	COG0535	radical SAM domain protein
GO005_19275	COG1131	(ABC) transporter
GO005_19280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GO005_19285	COG0612	Peptidase, M16
GO005_19290	COG0612	Peptidase, M16
GO005_19300	COG3391	amine dehydrogenase activity
GO005_19305	COG3391	amine dehydrogenase activity
GO005_19315	COG0457	Tetratricopeptide repeat
GO005_19330	COG0010	Belongs to the arginase family
GO005_19335	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GO005_19340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO005_19350	COG1994	Peptidase M50
GO005_19355	COG1942	4-Oxalocrotonate Tautomerase
GO005_19360	COG1846	Transcriptional regulator
GO005_19365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO005_19370	COG0477	Major facilitator Superfamily
GO005_19375	COG1959	2 iron, 2 sulfur cluster binding
GO005_19380	COG3465	dGTPase activity
GO005_19385	COG1078	dGTPase activity
GO005_19390	COG4844	belongs to the
GO005_19400	COG0697	spore germination
GO005_19405	COG0095	Lipoate-protein ligase
GO005_19410	COG0583	DNA-binding transcription factor activity
GO005_19415	COG0280	phosphate acetyltransferase
GO005_19420	COG3253	May function as heme-dependent peroxidase
GO005_19425	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_19430	COG0436	Aminotransferase
GO005_19435	COG2814	Major facilitator Superfamily
GO005_19440	COG0151	Belongs to the GarS family
GO005_19445	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_19450	COG1917	Cupin 2, conserved barrel domain protein
GO005_19455	COG0077	Prephenate dehydratase
GO005_19460	COG2814	Major facilitator Superfamily
GO005_19465	COG0833	amino acid
GO005_19470	COG4187	Peptidase family M20/M25/M40
GO005_19475	COG1012	belongs to the aldehyde dehydrogenase family
GO005_19480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO005_19490	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GO005_19495	COG1091	dTDP-4-dehydrorhamnose reductase activity
GO005_19500	COG1088	dTDP-glucose 4,6-dehydratase activity
GO005_19505	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GO005_19510	COG3980	spore coat polysaccharide biosynthesis protein
GO005_19515	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GO005_19520	COG2089	acid synthase
GO005_19525	COG0456	acetyltransferase
GO005_19530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO005_19535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO005_19540	COG0463	Glycosyl transferase, family 2
GO005_19550	COG2363	Small membrane protein
GO005_19555	COG2233	PERMEase
GO005_19565	COG1012	belongs to the aldehyde dehydrogenase family
GO005_19570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GO005_19575	COG1216	Glycosyl transferase, family 2
GO005_19580	COG0351	phosphomethylpyrimidine kinase
GO005_19590	COG1621	beta-fructofuranosidase activity
GO005_19595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_19595	COG1263	PTS System
GO005_19600	COG2116	formate transmembrane transporter activity
GO005_19605	COG3711	transcriptional antiterminator
GO005_19615	COG1404	Belongs to the peptidase S8 family
GO005_19620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO005_19625	COG0778	Nitroreductase
GO005_19630	COG0772	Belongs to the SEDS family
GO005_19640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO005_19645	COG1845	cytochrome c oxidase, subunit III
GO005_19650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO005_19655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO005_19660	COG2261	transglycosylase associated protein
GO005_19665	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GO005_19670	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO005_19675	COG2246	polysaccharide biosynthetic process
GO005_19680	COG1309	transcriptional regulator
GO005_19690	COG3162	membrane
GO005_19695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO005_19700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GO005_19705	COG2837	iron assimilation
GO005_19710	COG2822	iron ion transport
GO005_19715	COG0672	)-iron permease
GO005_19720	COG0352	thiamine-phosphate diphosphorylase activity
GO005_19725	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GO005_19730	COG0583	DNA-binding transcription factor activity
GO005_19735	COG1380	Effector of murein hydrolase LrgA
GO005_19740	COG1346	cytolysis
GO005_19745	COG2814	Major facilitator Superfamily
GO005_19750	COG4895	conserved protein (DUF2196)
GO005_19755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO005_19760	COG0346	lactoylglutathione lyase activity
GO005_19775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO005_19785	COG1263	PTS System
GO005_19785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_19790	COG3711	transcriptional antiterminator
GO005_19795	COG1442	glycosyl transferase family 8
GO005_19800	COG5522	Integral membrane protein (intg_mem_TP0381)
GO005_19805	COG1846	Transcriptional regulator
GO005_19810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO005_19815	COG2234	aminopeptidase activity
GO005_19830	COG2814	Major facilitator Superfamily
GO005_19835	COG2357	RelA SpoT domain protein
GO005_19840	COG1575	Belongs to the MenA family. Type 1 subfamily
GO005_19855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO005_19860	COG1696	Membrane protein involved in D-alanine export
GO005_19865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO005_19870	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GO005_19875	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GO005_19880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO005_19885	COG1486	melibiose metabolic process
GO005_19890	COG1447	Phosphotransferase system cellobiose-specific component IIA
GO005_19895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO005_19900	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO005_19905	COG3711	transcriptional antiterminator
GO005_19905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO005_19915	COG2094	Belongs to the DNA glycosylase MPG family
GO005_19920	COG0753	catalase activity
GO005_19925	COG2814	Major facilitator Superfamily
GO005_19930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GO005_19935	COG1131	(ABC) transporter
GO005_19955	COG1595	DNA-templated transcription, initiation
GO005_19960	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GO005_19965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GO005_19970	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GO005_19975	COG4988	ABC transporter
GO005_19980	COG1294	oxidase, subunit
GO005_19985	COG1271	oxidase subunit
GO005_19990	COG3493	citrate carrier protein
GO005_19995	COG0501	Belongs to the peptidase M48B family
GO005_20005	COG0726	polysaccharide deacetylase
GO005_20010	COG3842	ATPase activity
GO005_20015	COG2508	Transcriptional regulator
GO005_20025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO005_20035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO005_20045	COG4585	Histidine kinase
GO005_20050	COG2197	response regulator
GO005_20055	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO005_20065	COG4894	glucomannan catabolic process
GO005_20070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO005_20075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO005_20080	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_20085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO005_20090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GO005_20100	COG0500	methyltransferase
GO005_20105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO005_20120	COG0693	protein deglycase activity
GO005_20120	COG0753	catalase activity
GO005_20125	COG2851	Citrate transporter
GO005_20130	COG2273	Hydrolase Family 16
GO005_20135	COG3711	transcriptional antiterminator
GO005_20145	COG2270	Major facilitator Superfamily
GO005_20150	COG0513	Belongs to the DEAD box helicase family
GO005_20155	COG2755	lipolytic protein G-D-S-L family
GO005_20155	COG3401	FG-GAP repeat protein
GO005_20205	COG3209	COG3209 Rhs family protein
GO005_20215	COG0589	response to stress
GO005_20220	COG2723	6-phospho-beta-galactosidase activity
GO005_20225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO005_20225	COG1263	PTS System
GO005_20225	COG2190	(PTS) system
GO005_20235	COG5444	nuclease activity
GO005_20250	COG3507	Belongs to the glycosyl hydrolase 43 family
GO005_20265	COG2986	histidine ammonia-lyase
GO005_20270	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GO005_20275	COG1228	amidohydrolase
GO005_20280	COG0010	Belongs to the arginase family
GO005_20285	COG0833	amino acid
GO005_20290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GO005_20295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO005_20300	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO005_20305	COG2390	Transcriptional regulator
GO005_20315	COG3192	ethanolamine utilization protein
GO005_20320	COG2079	MmgE PrpD family protein
GO005_20325	COG1473	amidohydrolase
GO005_20330	COG1126	abc transporter atp-binding protein
GO005_20335	COG0765	amino acid transport
GO005_20340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO005_20345	COG0456	acetyltransferase
GO005_20350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO005_20355	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GO005_20360	COG0561	phosphatase activity
GO005_20390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO005_20395	COG5294	Protein conserved in bacteria
GO005_20400	COG0577	efflux transmembrane transporter activity
GO005_20405	COG1136	(ABC) transporter
GO005_20410	COG2205	protein histidine kinase activity
GO005_20415	COG0745	RESPONSE REGULATOR receiver
GO005_20420	COG0191	fructose-bisphosphate aldolase activity
GO005_20425	COG1082	Xylose isomerase domain protein TIM barrel
GO005_20430	COG1082	Xylose isomerase domain protein TIM barrel
GO005_20435	COG0673	inositol 2-dehydrogenase activity
GO005_20440	COG2814	Major facilitator Superfamily
GO005_20445	COG1082	Xylose isomerase domain protein TIM barrel
GO005_20450	COG3962	Belongs to the TPP enzyme family
GO005_20455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO005_20460	COG3718	enzyme involved in inositol metabolism
GO005_20465	COG1012	belongs to the aldehyde dehydrogenase family
GO005_20470	COG1349	DNA-binding transcription factor activity
GO005_20475	COG0667	Aldo Keto reductase
GO005_20490	COG2814	Major facilitator Superfamily
GO005_20495	COG0326	Molecular chaperone. Has ATPase activity
GO005_20505	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_20510	COG1309	transcriptional regulator
GO005_20515	COG1012	belongs to the aldehyde dehydrogenase family
GO005_20525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO005_20535	COG1714	RDD family
GO005_20540	COG2311	Membrane
GO005_20545	COG1917	Cupin 2, conserved barrel domain protein
GO005_20550	COG1309	transcriptional regulator
GO005_20555	COG1028	Short-chain dehydrogenase reductase Sdr
GO005_20560	COG1846	Transcriptional regulator
GO005_20565	COG1380	Effector of murein hydrolase LrgA
GO005_20570	COG1346	cytolysis
GO005_20575	COG5039	Polysaccharide pyruvyl transferase
GO005_20580	COG1929	Belongs to the glycerate kinase type-1 family
GO005_20585	COG1802	Transcriptional regulator
GO005_20590	COG1070	Carbohydrate kinase
GO005_20595	COG2610	gluconate transmembrane transporter activity
GO005_20600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO005_20605	COG0450	alkyl hydroperoxide reductase
GO005_20610	COG3634	alkyl hydroperoxide reductase activity
GO005_20615	COG2723	6-phospho-beta-galactosidase activity
GO005_20630	COG2188	Transcriptional regulator
GO005_20640	COG1131	(ABC) transporter
GO005_20645	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GO005_20655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GO005_20670	COG1063	alcohol dehydrogenase
GO005_20690	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GO005_20695	COG0456	acetyltransferase
GO005_20700	COG0457	Tetratricopeptide repeat
GO005_20710	COG0010	Belongs to the arginase family
GO005_20715	COG0833	amino acid
GO005_20720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO005_20725	COG3829	transcription factor binding
GO005_20730	COG5002	protein histidine kinase activity
GO005_20735	COG0745	RESPONSE REGULATOR receiver
GO005_20755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO005_20760	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GO005_20765	COG4853	Protein conserved in bacteria
GO005_20770	COG4863	YycH protein
GO005_20775	COG5002	protein histidine kinase activity
GO005_20780	COG0745	RESPONSE REGULATOR receiver
GO005_20810	COG0346	lactoylglutathione lyase activity
GO005_20815	COG0305	Participates in initiation and elongation during chromosome replication
GO005_20830	COG3093	addiction module antidote protein HigA
GO005_20835	COG2807	transmembrane transport
GO005_20840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO005_20845	COG0359	binds to the 23S rRNA
GO005_20850	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GO005_20855	COG4241	membrane
GO005_20865	COG5577	PFAM Coat F domain
GO005_20870	COG1733	regulation of RNA biosynthetic process
GO005_20875	COG1227	inorganic diphosphatase activity
GO005_20885	COG2271	Major facilitator Superfamily
GO005_20890	COG0789	Transcriptional regulator
GO005_20890	COG4978	Transcriptional regulator
GO005_20900	COG4319	ketosteroid isomerase
GO005_20905	COG1357	PFAM Pentapeptide repeats (8 copies)
GO005_20910	COG2814	Major facilitator Superfamily
GO005_20915	COG0583	DNA-binding transcription factor activity
GO005_20920	COG2153	protein acetylation
GO005_20930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO005_20935	COG1846	Transcriptional regulator
GO005_20940	COG2153	protein acetylation
GO005_20945	COG2364	Membrane
GO005_20950	COG0456	acetyltransferase
GO005_20955	COG2315	Protein conserved in bacteria
GO005_20960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO005_20970	COG2814	Major facilitator Superfamily
GO005_20980	COG1331	Highly conserved protein containing a thioredoxin domain
GO005_20995	COG0789	Transcriptional regulator
GO005_21000	COG0697	spore germination
GO005_21010	COG1280	lysine exporter protein (LysE YggA)
GO005_21015	COG1331	Highly conserved protein containing a thioredoxin domain
GO005_21020	COG1331	Highly conserved protein containing a thioredoxin domain
GO005_21025	COG1266	CAAX protease self-immunity
GO005_21030	COG2814	Major facilitator Superfamily
GO005_21030	COG0477	Major facilitator Superfamily
GO005_21035	COG0110	maltose O-acetyltransferase activity
GO005_21040	COG0346	lactoylglutathione lyase activity
GO005_21045	COG1609	Transcriptional regulator
GO005_21050	COG0708	Exodeoxyribonuclease III
GO005_21055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GO005_21060	COG0629	single-stranded DNA binding
GO005_21065	COG0360	Binds together with S18 to 16S ribosomal RNA
GO005_21070	COG0012	GTP binding
GO005_21075	COG0243	molybdopterin cofactor binding
GO005_21080	COG4481	Protein conserved in bacteria
GO005_21085	COG3949	Membrane
GO005_21095	COG1475	DNA binding
GO005_21100	COG1192	Involved in chromosome partitioning
GO005_21110	COG1475	DNA binding
GO005_21115	COG0357	Ribosomal RNA small subunit methyltransferase G
GO005_21120	COG0445	tRNA wobble uridine modification
GO005_21130	COG1847	R3H domain protein
GO005_21135	COG0706	membrane insertase activity
GO005_21140	COG0594	ribonuclease P activity