locus-tag class description BKN48_00010 ENOG4106SCS STAS domain BKN48_00030 ENOG4105FR1 rard protein BKN48_00050 ENOG41090U3 tautomerase BKN48_00065 ENOG4105FBA Phospholipase Carboxylesterase BKN48_00080 ENOG4105E1V na solute symporter BKN48_00100 ENOG4108VXD carboxy-peptidase BKN48_00105 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BKN48_00115 ENOG4106Z5R BKN48_00120 ENOG410841Q phosphoesterase PA-phosphatase related protein BKN48_00155 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BKN48_00160 ENOG4108TSC N-acetyltransferase BKN48_00165 ENOG4107S4Y M20 DapE family protein YgeY BKN48_00180 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BKN48_00220 ENOG4107T32 3-phytase (EC 3.1.3.8) BKN48_00225 ENOG4105C5E polysaccharide biosynthesis protein BKN48_00230 ENOG4105E0X reductase BKN48_00235 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BKN48_00255 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BKN48_00260 ENOG41090WU lipolytic protein G-D-S-L family BKN48_00265 ENOG4108KF3 Electron transport protein SCO1 SenC BKN48_00280 ENOG4105C7B Threonine dehydratase BKN48_00290 ENOG4108UT2 hemolysin iii BKN48_00300 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BKN48_00315 ENOG4107YX5 Pfam:DUF548 BKN48_00320 ENOG4108Y6J UPF0403 protein BKN48_00325 ENOG4105C01 Dihydroxy-acid dehydratase BKN48_00340 ENOG4108V06 Glutathione peroxidase BKN48_00345 ENOG4105CVG Homoserine O-transsuccinylase BKN48_00385 ENOG41081VK Ribonuclease BKN48_00415 ENOG410890F Dynamin family BKN48_00425 ENOG41065KQ synthase BKN48_00430 ENOG4105C2W permease BKN48_00435 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BKN48_00440 ENOG4105CTD carboxy-peptidase BKN48_00445 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) BKN48_00450 ENOG4108UHU Aldolase BKN48_00455 ENOG4105D7K pfkb domain protein BKN48_00460 ENOG4108M60 Transcriptional regulator BKN48_00470 ENOG4105CHR reductase BKN48_00475 ENOG4105DVT helicase BKN48_00485 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BKN48_00500 ENOG4108UKS UPF0398 protein BKN48_00510 ENOG4107X2U Inherit from COG: Exonuclease-like protein BKN48_00515 ENOG4108I5C dEAD DEAH box helicase BKN48_00565 ENOG4105BZ4 penicillin-binding protein BKN48_00575 ENOG4105CSM endonuclease III BKN48_00585 ENOG4105C5S asparaginyl-tRNA synthetase BKN48_00590 ENOG4105CHM Aminotransferase BKN48_00600 ENOG4105YAC BKN48_00605 ENOG4105DVT helicase BKN48_00610 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BKN48_00615 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BKN48_00620 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BKN48_00625 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BKN48_00630 ENOG4105DJ0 Poly(A) Polymerase BKN48_00635 ENOG4105CPK Glycosyl transferase (Group 1 BKN48_00640 ENOG4105FJR Lmbe family BKN48_00645 ENOG4108Z5K methylglyoxal synthase BKN48_00650 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BKN48_00655 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BKN48_00660 ENOG4108JYZ YitT family BKN48_00680 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BKN48_00700 ENOG41068YB TPR repeat-containing protein BKN48_00705 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BKN48_00725 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BKN48_00730 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BKN48_00740 ENOG4108I0Q anthranilate phosphoribosyltransferase BKN48_00745 ENOG4105CRQ synthase (Component I) BKN48_00750 ENOG4105KHN chorismate mutase BKN48_00755 ENOG4105D49 3-dehydroquinate synthase BKN48_00760 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BKN48_00765 ENOG4105BZU Histidine kinase BKN48_00775 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BKN48_00780 ENOG4105EAH synthase BKN48_00785 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BKN48_00790 ENOG4105XXQ heptaprenyl diphosphate synthase component I BKN48_00800 ENOG4105EUJ GTP cyclohydrolase i BKN48_00805 ENOG4105K70 DNA-binding protein BKN48_00810 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BKN48_00825 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BKN48_00830 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BKN48_00835 ENOG41065D1 BKN48_00840 ENOG4105S2F BKN48_00855 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BKN48_00860 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BKN48_00865 ENOG4105CAT Cytidine monophosphate kinase BKN48_00880 ENOG4105MSI germination protein ypeb BKN48_00890 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BKN48_00895 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BKN48_00910 ENOG4107RGJ metallophosphoesterase BKN48_00925 ENOG4105I7S Abortive infection protein BKN48_00930 ENOG4105C9U ATP-dependent DNA helicase RecQ BKN48_00935 ENOG4105T7X BKN48_00945 ENOG4108SAX Membrane BKN48_00950 ENOG4108JQ1 Dehydrogenase BKN48_00955 ENOG4105FF2 Type I DHQase BKN48_00970 ENOG4105BZU Histidine kinase BKN48_00975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN48_00980 ENOG4105CRE cytochrome C BKN48_00985 ENOG4107TWT Cytochrome c biogenesis protein BKN48_00995 ENOG4105FE9 pseudouridine synthase BKN48_01005 ENOG4108JIC nucleoside recognition domain protein BKN48_01010 ENOG4105DZ1 carboxypeptidase BKN48_01020 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BKN48_01025 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BKN48_01040 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BKN48_01045 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BKN48_01050 ENOG4108R6K riboflavin synthase, subunit alpha BKN48_01055 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BKN48_01065 ENOG4105C3F Signal peptidase i BKN48_01070 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BKN48_01080 ENOG4107ZE5 PPIases accelerate the folding of proteins BKN48_01085 ENOG4105PTM secreted protein BKN48_01090 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BKN48_01100 ENOG4105G6R Stage v sporulation protein ae BKN48_01110 ENOG4105CZ3 stage V sporulation protein ad BKN48_01115 ENOG41090VF Stage v sporulation protein ac BKN48_01130 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BKN48_01135 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BKN48_01140 ENOG41082AN stage II sporulation protein BKN48_01145 ENOG4105DZ1 carboxypeptidase BKN48_01150 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BKN48_01155 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BKN48_01160 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BKN48_01170 ENOG4105I3K Ferric uptake regulator, Fur family BKN48_01175 ENOG4105MZ9 stage II sporulation protein m BKN48_01190 ENOG4105DFD Na H antiporter BKN48_01195 ENOG4108IJ0 Aspartate ammonia-lyase BKN48_01200 ENOG4105HDK L-asparaginase BKN48_01205 ENOG4108IMY Transcriptional regulator BKN48_01215 ENOG4108YZ4 nudix hydrolase BKN48_01225 ENOG4105CPC Aldo Keto reductase BKN48_01245 ENOG4106HZJ BKN48_01250 ENOG4105RHY Pfam:UPF0157 BKN48_01255 ENOG4105KAC Antibiotic biosynthesis monooxygenase BKN48_01260 ENOG4108XET gCN5-related N-acetyltransferase BKN48_01270 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BKN48_01280 ENOG4105E5W Transporter BKN48_01290 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BKN48_01305 ENOG4108IXY short-chain dehydrogenase reductase BKN48_01310 ENOG41069FQ Metallo-beta-lactamase superfamily BKN48_01315 ENOG4105II7 pyrroline-5-carboxylate reductase BKN48_01325 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BKN48_01335 ENOG410861F 50S ribosomal protein L33 BKN48_01340 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BKN48_01345 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BKN48_01350 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BKN48_01355 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BKN48_01365 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BKN48_01370 ENOG4108NA0 Uncharacterized conserved protein (COG2071) BKN48_01375 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BKN48_01380 ENOG4108HNZ carboxyl transferase BKN48_01385 ENOG4108ZVT methylmalonyl-coA epimerase BKN48_01395 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BKN48_01400 ENOG4108QEG Membrane BKN48_01405 ENOG4105CDA abc transporter atp-binding protein BKN48_01410 ENOG4105E5Q amino acid AbC transporter BKN48_01415 ENOG4108HW3 (ABC) transporter BKN48_01420 ENOG4108Y6J UPF0403 protein BKN48_01425 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BKN48_01440 ENOG4105C7S Dehydrogenase BKN48_01445 ENOG4105CPP Dehydrogenase, E1 component BKN48_01460 ENOG4105CKM Branched-chain carboxylic acid kinase BKN48_01465 ENOG4107RDP Dehydrogenase BKN48_01475 ENOG4108JUB Transcriptional regulator BKN48_01480 ENOG4106CCJ Protein of unknown function (DUF2627) BKN48_01485 ENOG4105CR4 methylisocitrate lyase BKN48_01490 ENOG4105DXD 2-methylcitrate dehydratase BKN48_01500 ENOG4105C1G acyl-Coa dehydrogenase BKN48_01505 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BKN48_01515 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BKN48_01520 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BKN48_01535 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BKN48_01545 ENOG4107QQR Sporulation BKN48_01555 ENOG4105S1Z Stage IV sporulation protein B BKN48_01560 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BKN48_01565 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BKN48_01570 ENOG4105DX0 Hemolysin A BKN48_01580 ENOG4105CTB Polyprenyl synthetase BKN48_01585 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BKN48_01590 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BKN48_01595 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BKN48_01600 ENOG4105M7K Involved in the transcription termination process (By similarity) BKN48_01605 ENOG4108ZSR alkaline shock protein BKN48_01610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BKN48_01630 ENOG410644B Stage III sporulation protein af BKN48_01640 ENOG4105KQ4 Stage iii sporulation protein ad BKN48_01645 ENOG4108CQH stage III sporulation protein AC BKN48_01650 ENOG4105KR5 Stage iii sporulation protein BKN48_01655 ENOG4105CD2 stage iii sporulation protein aa BKN48_01665 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BKN48_01670 ENOG4105DC7 peptidase M24 BKN48_01675 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BKN48_01685 ENOG4105CBJ Metal-dependent enzyme BKN48_01700 ENOG4105KST dependent repressor BKN48_01705 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BKN48_01710 ENOG4105WZW rhodanese family BKN48_01715 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BKN48_01720 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BKN48_01725 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BKN48_01730 ENOG4105C0D helicase BKN48_01745 ENOG4108IMY Transcriptional regulator BKN48_01755 ENOG4105VFR signal peptidase BKN48_01820 ENOG4105C37 (CBS) domain BKN48_01845 ENOG4105C5X domain protein BKN48_01870 ENOG4105E0M Sulfatase BKN48_01885 ENOG4107ZXI Rhomboid family BKN48_01895 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BKN48_01900 ENOG4105WDJ 50S ribosomal protein L33 BKN48_01920 ENOG41068DG YceG-like family BKN48_01925 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BKN48_01930 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BKN48_01935 ENOG4105E2Z phosphate ABC transporter (Permease BKN48_01940 ENOG4105C8U phosphate abc transporter BKN48_01945 ENOG4105CVA phosphate BKN48_01950 ENOG4107RF6 penicillin-binding protein BKN48_01960 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BKN48_01965 ENOG4105SXS Protein of unknown function (DUF456) BKN48_01980 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BKN48_01985 ENOG41063Y9 BKN48_01990 ENOG4108U5J '-nucleotidase BKN48_01995 ENOG4105N80 Ferric uptake regulator, Fur family BKN48_02000 ENOG4108JYZ YitT family BKN48_02005 ENOG41069ZM Protein of unknown function (DUF2624) BKN48_02010 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BKN48_02025 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BKN48_02030 ENOG4105EGD dinuclear metal center protein, YbgI family BKN48_02045 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BKN48_02050 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BKN48_02055 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 BKN48_02060 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BKN48_02070 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BKN48_02075 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BKN48_02080 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BKN48_02090 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BKN48_02095 ENOG4105KG3 cytidine deaminase BKN48_02100 ENOG4107YR5 Diacylglycerol kinase BKN48_02105 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BKN48_02110 ENOG4105CTJ Metal Dependent Phosphohydrolase BKN48_02120 ENOG4105C9A Phoh family BKN48_02125 ENOG4105EI1 sporulation protein yqfd BKN48_02130 ENOG41068P3 sporulation protein YqfC BKN48_02140 ENOG4105DI5 UPF0365 protein BKN48_02145 ENOG4105F7J membrane-bound serine protease BKN48_02150 ENOG4105KTH gatB Yqey BKN48_02165 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BKN48_02170 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BKN48_02175 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BKN48_02185 ENOG4105CFG Acts as a chaperone (By similarity) BKN48_02190 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BKN48_02195 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BKN48_02200 ENOG4105CSA Coproporphyrinogen iii oxidase BKN48_02205 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BKN48_02215 ENOG4108ZRV stage ii sporulation protein p BKN48_02220 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BKN48_02225 ENOG41082YS Binds directly to 16S ribosomal RNA BKN48_02230 ENOG4105TQK DNA polymerase iii, delta' subunit BKN48_02240 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BKN48_02245 ENOG4108UK2 deaminase BKN48_02250 ENOG4105KQC Competence protein BKN48_02260 ENOG4108D32 Methyltransferase BKN48_02270 ENOG4108WF2 Metal Dependent Phosphohydrolase BKN48_02275 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BKN48_02280 ENOG410812S Rna-binding protein BKN48_02285 ENOG4105E2X shikimate dehydrogenase BKN48_02290 ENOG4105CQW ribosome biogenesis GTPase YqeH BKN48_02295 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BKN48_02315 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BKN48_02320 ENOG41080BT SNARE associated Golgi BKN48_02335 ENOG4105WFK nuclease BKN48_02340 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BKN48_02360 ENOG4108SWU Histidine kinase BKN48_02365 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BKN48_02370 ENOG4105DHF Membrane BKN48_02380 ENOG4108UYN gCN5-related N-acetyltransferase BKN48_02385 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BKN48_02390 ENOG41068VA BKN48_02395 ENOG41087NI Sulfite exporter TauE/SafE BKN48_02400 ENOG4105VFE sira family BKN48_02405 ENOG4107TPS domain protein BKN48_02415 ENOG4105VFE sira family BKN48_02420 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BKN48_02425 ENOG4105XTG Pfam:DUF156 BKN48_02430 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BKN48_02445 ENOG41090E6 transcriptional regulator MERR family BKN48_02460 ENOG4105C37 (CBS) domain BKN48_02475 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family BKN48_02480 ENOG4105H3G oxidoreductase BKN48_02485 ENOG4105PGM cation diffusion facilitator family transporter BKN48_02500 ENOG4105KMT branched-chain amino acid BKN48_02505 ENOG4108UMN azlc family BKN48_02510 ENOG4108ZRZ Transcriptional regulator (AsnC family) BKN48_02515 ENOG41067XF inhibitor BKN48_02540 ENOG41064BW Protein of unknown function (DUF2568) BKN48_02550 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BKN48_02555 ENOG4105EA8 2-Nitropropane dioxygenase BKN48_02560 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BKN48_02570 ENOG4107YCY Transcriptional regulator BKN48_02580 ENOG4105CHR reductase BKN48_02585 ENOG4108IUS Transketolase BKN48_02590 ENOG4105CV1 Transketolase (EC 2.2.1.1) BKN48_02595 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN48_02600 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BKN48_02605 ENOG4108MEK Metal-binding protein YodA BKN48_02610 ENOG410904A RNA polymerase BKN48_02615 ENOG4105CPC Aldo Keto reductase BKN48_02625 ENOG4108KAM Transcriptional regulator BKN48_02630 ENOG4105C7F AcnD-accessory protein PrpF BKN48_02635 ENOG41083Q9 chitosanase BKN48_02640 ENOG4105X5K response regulator receiver protein BKN48_02645 ENOG4108VQT Alpha beta hydrolase fold protein BKN48_02650 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BKN48_02655 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BKN48_02660 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase BKN48_02670 ENOG4105PGS Spore coat protein BKN48_02675 ENOG4105E2A Dehydrogenase BKN48_02690 ENOG4105VUF Transcriptional regulator BKN48_02700 ENOG4105DQ4 alcohol dehydrogenase BKN48_02705 ENOG4108Z0Z intracellular protease Pfpi family BKN48_02710 ENOG4108HKT sucrose-6-phosphate hydrolase BKN48_02715 ENOG4105F3R pts system mannose fructose sorbose family iid BKN48_02720 ENOG4105ETZ PTS System BKN48_02725 ENOG4108IQ3 PTS system BKN48_02730 ENOG4105YHU PTS system BKN48_02735 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BKN48_02740 ENOG4105C85 amino acid BKN48_02745 ENOG4105N14 lysine exporter protein LysE YggA BKN48_02750 ENOG4108NGU Transcriptional regulator BKN48_02755 ENOG4105JVQ RNA Polymerase BKN48_02760 ENOG4108P49 AntiSigma factor BKN48_02765 ENOG4105EXC Acyl-transferase BKN48_02770 ENOG4105WDR BKN48_02775 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BKN48_02780 ENOG41082JN Transcriptional regulator BKN48_02800 ENOG4105TMB Formate nitrite transporter BKN48_02805 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BKN48_02810 ENOG4108JB9 formate dehydrogenase BKN48_02825 ENOG4105C28 cystathionine BKN48_02840 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BKN48_02855 ENOG4107XRG penicillin-binding protein BKN48_02860 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BKN48_02865 ENOG4105DBI uridine monophosphokinase BKN48_02870 ENOG4105CFP Peptidase U32 BKN48_02875 ENOG4105XYU peptidase (U32 family) BKN48_02880 ENOG4108VQJ O-methyltransferase BKN48_02885 ENOG4105HHA aminodeoxychorismate lyase BKN48_02890 ENOG4105VPH UPF0473 protein BKN48_02895 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BKN48_02900 ENOG4105VBH UPF0297 protein BKN48_02905 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BKN48_02910 ENOG4105C02 permease BKN48_02915 ENOG4105CDA abc transporter atp-binding protein BKN48_02920 ENOG4105CT1 (ABC) transporter BKN48_02925 ENOG4105EAD ABC transporter BKN48_02930 ENOG4105DRP amino acid AbC transporter BKN48_02940 ENOG41060CR BKN48_02950 ENOG4105C7H Helicase, RecD TraA family BKN48_02960 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BKN48_02965 ENOG4105C3J Cysteine desulfurase BKN48_02975 ENOG4105D1H recombination factor protein RarA BKN48_02980 ENOG4105CUZ uba thif-type nad fad binding protein BKN48_02990 ENOG4105C9M aspartyl-trna synthetase BKN48_02995 ENOG4105CUT histidyl-tRNA synthetase BKN48_03005 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BKN48_03015 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BKN48_03020 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BKN48_03025 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BKN48_03030 ENOG41067VP Protein of unknown function (DUF1049) BKN48_03035 ENOG4105NCW Trka-c domain protein BKN48_03040 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BKN48_03050 ENOG4105CKP Polysaccharide Biosynthesis Protein BKN48_03055 ENOG4108QG2 Membrane BKN48_03060 ENOG4105NAP BKN48_03065 ENOG4105VIE preprotein translocase, subunit YajC BKN48_03070 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BKN48_03075 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BKN48_03080 ENOG41061AI Protein of unknown function (DUF2905) BKN48_03085 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BKN48_03090 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BKN48_03100 ENOG4105IE8 Alpha-ketoglutarate permease BKN48_03105 ENOG4105CK5 oxidoreductase BKN48_03130 ENOG4105BZG amino acid carrier protein BKN48_03135 ENOG4105CDY transcriptional regulatory protein BKN48_03145 ENOG4106678 morphogenetic protein associated with SpoVID BKN48_03150 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BKN48_03155 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BKN48_03160 ENOG4108IYU L-aspartate oxidase BKN48_03175 ENOG4105CQC Prephenate dehydratase BKN48_03180 ENOG41090I5 UPF0735 ACT domain-containing protein BKN48_03185 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BKN48_03200 ENOG4105K46 50S ribosomal protein l27 BKN48_03205 ENOG4105X36 (ribosomal) protein BKN48_03210 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BKN48_03225 ENOG4107QMS site-determining protein BKN48_03230 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BKN48_03235 ENOG4105YHC Rod shape-determining protein MreD BKN48_03240 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BKN48_03245 ENOG4105DFF Rod shape-determining protein mreb BKN48_03250 ENOG4105W5Q DNA repair protein (RadC BKN48_03255 ENOG4108Z03 MAF-like protein BKN48_03265 ENOG4106A3R peptidase BKN48_03270 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BKN48_03275 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BKN48_03285 ENOG4106AR7 Spore coat protein BKN48_03290 ENOG41068KH stage VI sporulation protein D BKN48_03295 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BKN48_03300 ENOG4105D52 delta-aminolevulinic acid dehydratase BKN48_03310 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BKN48_03320 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BKN48_03330 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BKN48_03335 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BKN48_03340 ENOG4108IUQ atp-dependent protease BKN48_03345 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BKN48_03350 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BKN48_03360 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BKN48_03365 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BKN48_03370 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BKN48_03375 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BKN48_03380 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BKN48_03385 ENOG4108ZP8 Acetolactate synthase small subunit BKN48_03390 ENOG4105C7K acetolactate synthase BKN48_03400 ENOG4105I4A GCN5-related N-acetyltransferase BKN48_03410 ENOG4107KM7 Heat induced stress protein YflT BKN48_03420 ENOG4105M59 Phosphodiesterase, mj0936 family BKN48_03425 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BKN48_03430 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BKN48_03435 ENOG4108XJQ germination protein BKN48_03440 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BKN48_03445 ENOG41067TZ transcriptional regulator, MarR family BKN48_03450 ENOG4105PFC Transcriptional regulator BKN48_03460 ENOG4105E33 succinate dehydrogenase BKN48_03470 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BKN48_03485 ENOG4105CFH Aspartokinase BKN48_03490 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BKN48_03495 ENOG4105K63 Thioredoxin BKN48_03500 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BKN48_03505 ENOG4105C10 Electron transfer flavoprotein BKN48_03510 ENOG4105BZJ Electron transfer flavoprotein BKN48_03515 ENOG41060WC Enoyl-CoA hydratase BKN48_03520 ENOG4107Z3H Transcriptional regulator, TetR family BKN48_03525 ENOG4105CEY Amp-dependent synthetase and ligase BKN48_03535 ENOG4105C98 muts2 protein BKN48_03540 ENOG4105DCG PHP domain protein BKN48_03555 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BKN48_03560 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BKN48_03565 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BKN48_03575 ENOG4108RWN rrna methyltransferase BKN48_03580 ENOG41067MF small acid-soluble spore protein BKN48_03590 ENOG4105CQB FAD linked oxidase domain protein BKN48_03595 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BKN48_03610 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BKN48_03615 ENOG4105DRS transport system, permease BKN48_03630 ENOG4108MDK Dehydrogenase BKN48_03640 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BKN48_03645 ENOG4105EF1 ribulokinase BKN48_03655 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BKN48_03660 ENOG4105CN9 Peptidase m42 family protein BKN48_03670 ENOG410696E Membrane BKN48_03675 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BKN48_03680 ENOG4105VJV 50s ribosomal protein L35 BKN48_03685 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BKN48_03695 ENOG41067MG lrgb family BKN48_03705 ENOG4105DY9 regulatoR BKN48_03710 ENOG4108HRK Histidine kinase BKN48_03715 ENOG4105U0R haloacid dehalogenase-like hydrolase BKN48_03720 ENOG4105C22 threonyL-tRNA synthetase BKN48_03725 ENOG4108TDW sporulation protein YtxC BKN48_03745 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BKN48_03750 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BKN48_03755 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BKN48_03760 ENOG4105KVH Transcriptional regulator BKN48_03765 ENOG4105F27 Major Facilitator BKN48_03770 ENOG4105CV8 reductase BKN48_03775 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BKN48_03790 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BKN48_03795 ENOG4105C2M dna polymerase I BKN48_03800 ENOG4105BZU Histidine kinase BKN48_03805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BKN48_03810 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BKN48_03815 ENOG4108HMX isocitrate dehydrogenase (NADP) BKN48_03820 ENOG4105BZN citrate synthase BKN48_03830 ENOG4108REF Sporulation integral membrane protein ytvi BKN48_03835 ENOG4105FS0 cytoplasmic membrane protein BKN48_03840 ENOG4105CA9 Pyruvate kinase BKN48_03845 ENOG4105CTQ phosphohexokinase BKN48_03855 ENOG4108IEY Carboxyl transferase domain BKN48_03860 ENOG4105C6K Malic enzyme BKN48_03865 ENOG4105C0B DNA polymerase III (alpha subunit) BKN48_03870 ENOG4105VV2 BKN48_03880 ENOG4106EVM BKN48_03885 ENOG4105SFS phosphoesterase RecJ domain protein BKN48_03900 ENOG4105E8R UPF0173 metal-dependent hydrolase BKN48_03915 ENOG4105CH7 arginosuccinase BKN48_03920 ENOG4105CDH Citrulline--aspartate ligase BKN48_03925 ENOG4105EPU Molybdenum cofactor synthesis domain protein BKN48_03930 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BKN48_03940 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BKN48_03945 ENOG4105KBJ sporulation protein ytfj BKN48_03955 ENOG4105VK3 rdd domain containing protein BKN48_03960 ENOG4105D07 Signal peptide peptidase, SppA BKN48_03965 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BKN48_03970 ENOG4105EFZ amidohydrolase BKN48_03975 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BKN48_04010 ENOG4105U5Y Transcriptional regulator BKN48_04020 ENOG4105BZU Histidine kinase BKN48_04025 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BKN48_04035 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BKN48_04045 ENOG4105F1V Acetoin utilization protein BKN48_04050 ENOG4105W87 Cbs domain BKN48_04055 ENOG4105DGU Histone deacetylase BKN48_04060 ENOG4105ER2 Ompa motb domain protein BKN48_04065 ENOG4107R0U MotA TolQ exbB proton channel BKN48_04070 ENOG4105ETE Transcriptional regulator (LacI family BKN48_04075 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BKN48_04095 ENOG4105DFU Cell wall formation (By similarity) BKN48_04105 ENOG4108VDD TRNA binding domain protein BKN48_04120 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BKN48_04135 ENOG4105C6K Malic enzyme BKN48_04140 ENOG4105C8F Beta-lactamase domain protein BKN48_04145 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BKN48_04155 ENOG4108V15 phosphotransferase enzyme family BKN48_04160 ENOG4108IUM Glycogen debranching enzyme BKN48_04175 ENOG4107F58 2'-5' rna ligase BKN48_04180 ENOG4105C6T cysteine synthase BKN48_04185 ENOG4107QSE Dipeptidase BKN48_04190 ENOG4105C7N Xanthine uracil vitamin C permease BKN48_04205 ENOG4105YW5 deoR family transcriptional regulator BKN48_04220 ENOG4105CBX hi0933 family BKN48_04225 ENOG4105C94 Transporter BKN48_04235 ENOG4105MU9 integral membrane protein BKN48_04240 ENOG4105DDC Oxidoreductase domain protein BKN48_04250 ENOG4105F5H Glycosyl Hydrolase Family 88 BKN48_04260 ENOG41075H3 AraC family transcriptional regulator BKN48_04270 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BKN48_04280 ENOG4106A3M Cytochrome p-450 BKN48_04285 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BKN48_04295 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BKN48_04300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BKN48_04310 ENOG4105NTD Inherit from COG: Hydrolase BKN48_04325 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BKN48_04330 ENOG4105I1K ABC transporter BKN48_04340 ENOG41085GJ domain protein BKN48_04345 ENOG4105C8T Leucyl-tRNA synthetase BKN48_04355 ENOG4105BZU Histidine kinase BKN48_04360 ENOG410605W Major Facilitator BKN48_04365 ENOG4106UBQ BKN48_04375 ENOG4105C19 ABC transporter BKN48_04380 ENOG4105EWM Histidine kinase BKN48_04390 ENOG4107R34 abc transporter permease protein BKN48_04395 ENOG4105C19 ABC transporter BKN48_04410 ENOG4105DVE abc transporter atp-binding protein BKN48_04415 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BKN48_04430 ENOG4105N5T Radical SAM Protein BKN48_04445 ENOG4105E8V Alpha Beta Hydrolase Fold protein BKN48_04450 ENOG4108Z0R Transferase BKN48_04455 ENOG4105C85 amino acid BKN48_04460 ENOG4105CAQ asparagine synthetase BKN48_04465 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BKN48_04470 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BKN48_04485 ENOG4105D2X ABC transporter substrate-binding protein BKN48_04495 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BKN48_04510 ENOG4108RMU ferritin dps family protein BKN48_04525 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BKN48_04530 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BKN48_04535 ENOG4108V2W Carbonate dehydratase BKN48_04560 ENOG4105CC5 ABC transporter BKN48_04565 ENOG4105CC5 ABC transporter BKN48_04570 ENOG4105DIK (ABC) transporter BKN48_04575 ENOG4105DSE periplasmic solute binding protein BKN48_04580 ENOG4105DTQ mandelate racemase muconate lactonizing BKN48_04585 ENOG4105CEY Amp-dependent synthetase and ligase BKN48_04590 ENOG4108IPT Naphthoate synthase BKN48_04595 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BKN48_04600 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BKN48_04605 ENOG4105E4F Isochorismate synthase BKN48_04625 ENOG4108IAJ Nad-dependent epimerase dehydratase BKN48_04630 ENOG4107SBE Glycosyl transferase (Group 1 BKN48_04645 ENOG4107SBE Glycosyl transferase (Group 1 BKN48_04650 ENOG4108KS4 Spore coat protein BKN48_04665 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BKN48_04675 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BKN48_04810 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BKN48_04815 ENOG4105VRR gCN5-related N-acetyltransferase BKN48_04820 ENOG4105DZ6 Band 7 protein BKN48_04830 ENOG4106DF1 BKN48_04835 ENOG4108VNY MOSC domain protein BKN48_04840 ENOG4108JB8 alcohol dehydrogenase BKN48_04845 ENOG4105C26 Dehydrogenase BKN48_04850 ENOG4105TRT Transcriptional regulator BKN48_04865 ENOG4105CZN Potassium uptake protein BKN48_04870 ENOG4107I77 yiaA/B two helix domain BKN48_04875 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BKN48_04895 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BKN48_04905 ENOG4105EE0 oxidoreductase BKN48_04910 ENOG4105DKG l-rhamnose isomerase BKN48_04915 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) BKN48_04920 ENOG4105DET Rhamnulokinase BKN48_04925 ENOG4105E98 transcriptional regulator DeoR family BKN48_04935 ENOG4105C8Q Methyl-accepting chemotaxis BKN48_04940 ENOG4105C8Q Methyl-accepting chemotaxis BKN48_04945 ENOG4105C8Q Methyl-accepting chemotaxis BKN48_04950 ENOG4105C8Q Methyl-accepting chemotaxis BKN48_04965 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BKN48_04975 ENOG4105C37 (CBS) domain BKN48_04990 ENOG4107PBV potassium channel BKN48_04995 ENOG4107PBV potassium channel BKN48_05010 ENOG4107QYV phosphohexose isomerase BKN48_05020 ENOG4107QW4 alcohol dehydrogenase BKN48_05025 ENOG4105WG9 Conserved Protein BKN48_05035 ENOG4105CHM Aminotransferase BKN48_05040 ENOG4108ZB6 transcriptional regulator AsnC family BKN48_05045 ENOG4108MUZ hydrolase BKN48_05055 ENOG4105C87 Aminotransferase class I and II BKN48_05060 ENOG4108HGU Histidine kinase BKN48_05065 ENOG4105Y38 Kinase-associated protein B BKN48_05085 ENOG4105BZ4 penicillin-binding protein BKN48_05090 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BKN48_05105 ENOG4108MRH transcriptional regulatory protein BKN48_05110 ENOG4105DIH basic membrane BKN48_05115 ENOG4108JQ9 ABC transporter BKN48_05120 ENOG4105UIB (ABC) transporter BKN48_05140 ENOG4105D65 subunit l BKN48_05145 ENOG4105HC0 Na H antiporter BKN48_05150 ENOG4108ZE9 Monovalent cation H antiporter subunit C BKN48_05155 ENOG4108JPZ Monovalent cation H antiporter subunit D BKN48_05160 ENOG4105SC1 monovalent cation H antiporter subunit E BKN48_05170 ENOG4105KJM monovalent cation h antiporter subunit g BKN48_05175 ENOG4105KA0 thioesterase Superfamily protein BKN48_05185 ENOG4105BZU Histidine kinase BKN48_05210 ENOG4105D58 Diguanylate phosphodiesterase BKN48_05215 ENOG4105DAP Nicotinate phosphoribosyltransferase BKN48_05240 ENOG4105C02 permease BKN48_05260 ENOG410904N short-chain dehydrogenase reductase BKN48_05295 ENOG4108K8K Transcriptional regulator BKN48_05300 ENOG4105DCF alanine dehydrogenase BKN48_05310 ENOG4105WQT MbtH domain protein BKN48_05315 ENOG4105CEY Amp-dependent synthetase and ligase BKN48_05320 ENOG4105WQI isochorismatase BKN48_05325 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BKN48_05330 ENOG4105E4F Isochorismate synthase BKN48_05335 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BKN48_05340 ENOG4105NIV Esterase BKN48_05360 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BKN48_05370 ENOG41069ER domain protein BKN48_05385 ENOG4105CEP NADH dehydrogenase BKN48_05390 ENOG4105CAY ferredoxin--nadp reductase BKN48_05410 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BKN48_05415 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BKN48_05430 ENOG4105ZKE UPF0349 protein BKN48_05445 ENOG41083MR nifu domain-containing protein BKN48_05450 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BKN48_05455 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BKN48_05460 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BKN48_05465 ENOG4105D6E homoserine dehydrogenase BKN48_05475 ENOG4108W5N phosphatidylglycerophosphatase a BKN48_05480 ENOG4105D4U had-superfamily hydrolase, subfamily iia BKN48_05490 ENOG4105MMD transcriptional regulator BKN48_05495 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BKN48_05500 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BKN48_05505 ENOG4105FAA peptidase M23 BKN48_05510 ENOG4108YTE sporulation protein YunB BKN48_05515 ENOG4105KZD Domain of unknown function (DUF1805) BKN48_05520 ENOG4107R8B 5'-nucleotidase BKN48_05530 ENOG4105I3N Conserved Protein BKN48_05540 ENOG4105CD3 dihydroorotase BKN48_05545 ENOG4105G9B Transcriptional regulator BKN48_05560 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) BKN48_05565 ENOG4105VT2 5-hydroxyisourate hydrolase BKN48_05575 ENOG4107YV9 domain protein BKN48_05580 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BKN48_05595 ENOG4105XRQ Xanthine dehydrogenase accessory factor BKN48_05600 ENOG4105C5R Aminotransferase BKN48_05615 ENOG4108K8S endonuclease I BKN48_05620 ENOG4108IJ9 (ABC) transporter BKN48_05625 ENOG4105FDP GntR family transcriptional regulator BKN48_05630 ENOG4108KPW sugar kinase BKN48_05635 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BKN48_05640 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BKN48_05645 ENOG4105XN3 extracellular solute-binding protein family 1 BKN48_05650 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BKN48_05655 ENOG4105PKS Excinuclease abc c subunit domain protein BKN48_05660 ENOG4107VFR oxidoreductase BKN48_05675 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BKN48_05680 ENOG4105NPE arsR family transcriptional regulator BKN48_05685 ENOG4105DIW FeS assembly protein SUFB BKN48_05690 ENOG4108UNV SUF system FeS assembly protein, NifU family BKN48_05695 ENOG4105C9B Cysteine desulfurase BKN48_05700 ENOG4105JRK feS assembly protein SufD BKN48_05705 ENOG4105C3K feS assembly ATPase SufC BKN48_05720 ENOG4105D01 (LipO)protein BKN48_05725 ENOG4108UMI ABC transporter, permease BKN48_05730 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BKN48_05755 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BKN48_05760 ENOG41080E8 Transcriptional regulator, Spx MgsR family BKN48_05765 ENOG4105C1G acyl-Coa dehydrogenase BKN48_05770 ENOG4105CHU acetyl-coa acetyltransferase BKN48_05800 ENOG41067TZ transcriptional regulator, MarR family BKN48_05805 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN48_05810 ENOG4105MDS 4-oxalocrotonate tautomerase BKN48_05820 ENOG4105EGI Transcriptional regulator BKN48_05830 ENOG4105E0A ABC, transporter BKN48_05845 ENOG4105E1F short-chain dehydrogenase reductase BKN48_05850 ENOG4105HUF DNA protection during starvation protein BKN48_05855 ENOG4105C0H protease BKN48_05865 ENOG4105F3H Histidine kinase BKN48_05875 ENOG41067SE Tetr family transcriptional regulator BKN48_05880 ENOG4105C9Q fumarate hydratase class II BKN48_05905 ENOG4105WH1 Two component transcriptional regulator luxr family BKN48_05910 ENOG4105ENE Histidine kinase BKN48_05925 ENOG41087YS Phage shock protein A BKN48_05940 ENOG4108WBT adenosyltransferase BKN48_05945 ENOG4105E0A ABC, transporter BKN48_05950 ENOG4105EHG Permease protein BKN48_05955 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BKN48_05960 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BKN48_05965 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BKN48_05975 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BKN48_05985 ENOG4106DF4 Sigma-70, region 4 BKN48_05995 ENOG4105F0F Oxalate decarboxylase BKN48_06005 ENOG4107RBB ABC transporter, permease BKN48_06010 ENOG4105C19 ABC transporter BKN48_06015 ENOG4108WMK Efflux transporter RND family MFP subunit BKN48_06020 ENOG4105E0A ABC, transporter BKN48_06025 ENOG4105EHG Permease protein BKN48_06030 ENOG4105DQ5 transport system permease protein BKN48_06040 ENOG4105D5Q Arginine ornithine antiporter BKN48_06050 ENOG4107K5X Membrane-bound metal-dependent hydrolase BKN48_06055 ENOG4107QZ2 Sulfatase BKN48_06060 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BKN48_06065 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BKN48_06070 ENOG4105E0C molybdate abc transporter BKN48_06085 ENOG4105EEQ Na H antiporter BKN48_06090 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BKN48_06095 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BKN48_06100 ENOG4105EEM helicase BKN48_06110 ENOG4105EN6 Membrane BKN48_06120 ENOG4107ZQN disulfide bond BKN48_06125 ENOG4105C59 p-type ATPase BKN48_06130 ENOG4105C59 p-type ATPase BKN48_06135 ENOG410681U heavy metal transport detoxification protein BKN48_06140 ENOG4105VPX protein, conserved in bacteria BKN48_06145 ENOG4105D9R oxidoreductase BKN48_06150 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BKN48_06155 ENOG4105ME7 Membrane BKN48_06160 ENOG4105RXJ BKN48_06165 ENOG4105KPY Small multidrug resistance protein BKN48_06170 ENOG4105KBX Transcriptional regulator, TetR family BKN48_06175 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BKN48_06195 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BKN48_06200 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BKN48_06210 ENOG4105XZU Preprotein translocase, subunit SecG BKN48_06235 ENOG4105KVH Transcriptional regulator BKN48_06240 ENOG4105C8Q Methyl-accepting chemotaxis BKN48_06245 ENOG4105R40 Glycine betaine carnitine choline BKN48_06250 ENOG4108HQR Glycine betaine BKN48_06255 ENOG4105E90 ABC transporter BKN48_06260 ENOG4108IJ8 ABC transporter BKN48_06265 ENOG4107HG4 Transcriptional regulator BKN48_06270 ENOG4105R40 Glycine betaine carnitine choline BKN48_06275 ENOG4108HQR Glycine betaine BKN48_06280 ENOG4105E90 ABC transporter BKN48_06285 ENOG4108IJ8 ABC transporter BKN48_06290 ENOG4107HG4 Transcriptional regulator BKN48_06295 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BKN48_06300 ENOG4108QCI YvbH-like oligomerisation region BKN48_06310 ENOG4105T65 Membrane-associated protein BKN48_06315 ENOG4108W0I acetyltransferase BKN48_06320 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BKN48_06325 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BKN48_06330 ENOG4105CP7 Triose-phosphate isomerase BKN48_06335 ENOG4105BZA Phosphoglycerate kinase BKN48_06345 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BKN48_06360 ENOG4105CMD Transcriptional regulator, GntR family BKN48_06365 ENOG4105DEN Luciferase family BKN48_06370 ENOG4105GZI Transcriptional regulator BKN48_06375 ENOG4107RT3 EamA-like transporter family BKN48_06385 ENOG4105VRS hydrolase family 18 BKN48_06390 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BKN48_06395 ENOG4107QR9 Iron-sulfur cluster binding protein BKN48_06400 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BKN48_06410 ENOG4105BZU Histidine kinase BKN48_06415 ENOG4105KCT ABC transporter BKN48_06420 ENOG4108M15 ABC transporter BKN48_06425 ENOG4107R6F Alpha Beta Hydrolase Fold protein BKN48_06430 ENOG4108MJI response regulator BKN48_06445 ENOG4105EG2 ABC transporter, permease BKN48_06455 ENOG4107FKK extracellular solute-binding protein family 1 BKN48_06465 ENOG4105JXH GntR family transcriptional regulator BKN48_06470 ENOG4105DAA L-lactate BKN48_06475 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BKN48_06485 ENOG4108ZPC Polysaccharide pyruvyl transferase BKN48_06490 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BKN48_06495 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BKN48_06500 ENOG4105D3Q Sugar transferase BKN48_06510 ENOG4105K64 Glycosyl transferase, family 2 BKN48_06520 ENOG4107QRS glycosyltransferase group 2 family protein BKN48_06525 ENOG41068W6 Capsular polysaccharide biosynthesis protein BKN48_06530 ENOG4108KMV Glycosyl transferase (Group 1 BKN48_06535 ENOG4105K64 Glycosyl transferase, family 2 BKN48_06540 ENOG4108PQP glycosyl transferase group 1 BKN48_06550 ENOG4108QV3 biosynthesis protein BKN48_06555 ENOG4105HTX biosynthesis protein BKN48_06565 ENOG4105EBR Carboxylesterase BKN48_06575 ENOG4105PY6 Phenolic acid decarboxylase BKN48_06580 ENOG4105NI3 Protein of unknown function (DUF3237) BKN48_06590 ENOG4105FQP Beta-lactamase BKN48_06595 ENOG4105EDQ levansucrase EC 2.4.1.10 BKN48_06600 ENOG4108HKT sucrose-6-phosphate hydrolase BKN48_06605 ENOG4107QTZ amino acid BKN48_06635 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BKN48_06640 ENOG4107URF beta-phospho-glucomutase BKN48_06645 ENOG4105CG3 alpha amylase, catalytic region BKN48_06660 ENOG4105EG2 ABC transporter, permease BKN48_06665 ENOG4105D56 permease protein BKN48_06670 ENOG4107FKK extracellular solute-binding protein family 1 BKN48_06675 ENOG4108IUK alpha amylase, catalytic BKN48_06680 ENOG4105FKQ transcriptional regulator BKN48_06685 ENOG4108URH decarboxylase BKN48_06690 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BKN48_06695 ENOG4105CHH sulfate transporter BKN48_06700 ENOG4108V2W Carbonate dehydratase BKN48_06705 ENOG4105C5I Dehydrogenase BKN48_06715 ENOG4105C19 ABC transporter BKN48_06720 ENOG4105EWM Histidine kinase BKN48_06730 ENOG4107A6P BKN48_06735 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BKN48_06740 ENOG4105KRI phosphocarrier protein (HPr BKN48_06745 ENOG4105CIE May be required for sporulation (By similarity) BKN48_06750 ENOG4105CHW UPF0052 protein BKN48_06755 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BKN48_06760 ENOG4108Z4K mutator MutT protein BKN48_06765 ENOG4105C3M thioredoxin reductase BKN48_06780 ENOG4105BZ1 (ABC) transporter BKN48_06790 ENOG4106FGC BKN48_06800 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BKN48_06805 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BKN48_06810 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BKN48_06815 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BKN48_06820 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BKN48_06825 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BKN48_06830 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BKN48_06835 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BKN48_06845 ENOG4108E16 pectate lyase BKN48_06850 ENOG4108S4C acetyltransferase BKN48_06855 ENOG4107XGZ Hydrolase BKN48_06860 ENOG4105HKU nucleoside recognition domain-containing protein BKN48_06865 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BKN48_06870 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BKN48_06875 ENOG4105CE4 GlcNAc 6-P deacetylase BKN48_06880 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BKN48_06885 ENOG4105FDP GntR family transcriptional regulator BKN48_06890 ENOG41088CQ domain protein BKN48_06895 ENOG41086DT Membrane protein of unknown function BKN48_06900 ENOG41067S9 phage shock protein C, PspC BKN48_06905 ENOG4108PY7 BKN48_06920 ENOG4105I03 Flagellin BKN48_06925 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BKN48_06930 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BKN48_06945 ENOG4105MKU Transcriptional regulator BKN48_06965 ENOG4105CN1 protease BKN48_06970 ENOG4105CRP Part of the ABC transporter FtsEX involved in BKN48_06975 ENOG4105CAK Cell division ATP-binding protein ftsE BKN48_06990 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BKN48_07000 ENOG4105MS2 ribosomal subunit Interface protein BKN48_07015 ENOG4105MQ3 flagellar protein FliS BKN48_07020 ENOG4107RT6 flagellar hook-associated BKN48_07025 ENOG41083S7 flagellar protein FlaG BKN48_07030 ENOG4105I03 Flagellin BKN48_07035 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BKN48_07040 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BKN48_07045 ENOG4105MKD BKN48_07050 ENOG4105DTJ flagellar hook-associated protein BKN48_07055 ENOG4105E1Q flagellar hook-associated protein BKN48_07070 ENOG4105RU3 BKN48_07075 ENOG41081UC Inherit from COG: Competence protein BKN48_07095 ENOG4105WH1 Two component transcriptional regulator luxr family BKN48_07100 ENOG4105BZU Histidine kinase BKN48_07105 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BKN48_07110 ENOG4108KGH TRANSCRIPTIONal BKN48_07115 ENOG4105ESV Glycosyl transferase, family 4 BKN48_07120 ENOG4107EF8 Glycosyl transferase (Group 1 BKN48_07135 ENOG4105QZI O-Antigen Polymerase BKN48_07140 ENOG4105C6Y Udp-glucose 6-dehydrogenase BKN48_07145 ENOG4107RA4 Glycosyl transferase (Group 1 BKN48_07150 ENOG4105PSV Polysaccharide Biosynthesis Protein BKN48_07155 ENOG4105D3Q Sugar transferase BKN48_07165 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BKN48_07170 ENOG4105JFG SpoIID LytB domain protein BKN48_07185 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BKN48_07205 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BKN48_07210 ENOG4105EY8 ABC transporter BKN48_07220 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BKN48_07270 ENOG4105DG6 mannose-6-phosphate isomerase BKN48_07290 ENOG4108NHD germination protein BKN48_07295 ENOG4105C54 Major Facilitator superfamily BKN48_07300 ENOG4108KGH TRANSCRIPTIONal BKN48_07305 ENOG4105J7I hydrolase BKN48_07310 ENOG4105K4H Nlp p60 protein BKN48_07320 ENOG4105PNM synthesis protein BKN48_07330 ENOG4105N98 Capsule biosynthesis protein capB BKN48_07335 ENOG4105ETE Transcriptional regulator (LacI family BKN48_07340 ENOG4108RVA ribokinase BKN48_07345 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BKN48_07350 ENOG4105C2J ABC transporter BKN48_07355 ENOG4105CNN ABC, transporter BKN48_07360 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BKN48_07375 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BKN48_07380 ENOG4107FQX Alpha-acetolactate decarboxylase BKN48_07390 ENOG4107RSM transcriptional regulator BKN48_07405 ENOG4106UIA BKN48_07420 ENOG4107XC4 flavin reductase domain protein, FMN-binding BKN48_07430 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BKN48_07440 ENOG4105CAH Chromate BKN48_07445 ENOG4105FGV Chromate BKN48_07450 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BKN48_07475 ENOG4108XI2 Domain of unknown function (DUF1963) BKN48_07480 ENOG4105C6Y Udp-glucose 6-dehydrogenase BKN48_07485 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BKN48_07490 ENOG4107YJ4 chain length determinant protein BKN48_07495 ENOG4105HTX biosynthesis protein BKN48_07505 ENOG4105KBK Zinc finger, swim domain protein BKN48_07510 ENOG4105C0D helicase BKN48_07515 ENOG410667J hydrolase BKN48_07520 ENOG4105E98 transcriptional regulator DeoR family BKN48_07525 ENOG4105Z8H single-stranded DNA-binding protein BKN48_07550 ENOG4108VAC response regulator BKN48_07560 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BKN48_07565 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BKN48_07575 ENOG4105CGA flagellar basal-body rod protein FlgG BKN48_07585 ENOG4105DFF Rod shape-determining protein mreb BKN48_07590 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BKN48_07595 ENOG4107MII Sugar-specific transcriptional regulator TrmB BKN48_07600 ENOG4105CZM Major Facilitator BKN48_07605 ENOG4108M26 parallel beta-helix repeat protein BKN48_07610 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BKN48_07615 ENOG41080V3 Major Facilitator superfamily BKN48_07620 ENOG4105D3W isochorismatase BKN48_07625 ENOG4107P26 BKN48_07630 ENOG4105BZU Histidine kinase BKN48_07640 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BKN48_07650 ENOG4105FRN stage II sporulation protein BKN48_07655 ENOG4107TCE N-acetyltransferase BKN48_07675 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BKN48_07680 ENOG4107TXC Transcriptional regulator BKN48_07685 ENOG4106BRK BKN48_07690 ENOG4108RYK Nad-dependent epimerase dehydratase BKN48_07695 ENOG4108Z40 Transcriptional regulator BKN48_07700 ENOG4105CQM Urea amidohydrolase subunit alpha BKN48_07705 ENOG4105KI2 Urea amidohydrolase subunit beta BKN48_07710 ENOG4108YZ9 Urea amidohydrolase subunit gamma BKN48_07745 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BKN48_07755 ENOG4108TF4 von Willebrand factor, type A BKN48_07770 ENOG4105JFG SpoIID LytB domain protein BKN48_07775 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BKN48_07785 ENOG4106778 Protein of unknown function (DUF1146) BKN48_07795 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BKN48_07800 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BKN48_07805 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BKN48_07810 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BKN48_07835 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) BKN48_07845 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BKN48_07850 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BKN48_07855 ENOG4108UIC UPF0340 protein BKN48_07860 ENOG4108YZG isomerase BKN48_07865 ENOG4107WAU Protein tyrosine phosphatase BKN48_07870 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BKN48_07875 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BKN48_07885 ENOG4108ZXQ stage ii sporulation protein r BKN48_07900 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BKN48_07905 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BKN48_07910 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BKN48_07920 ENOG4107TT2 Auxin Efflux Carrier BKN48_07925 ENOG4105C6K Malic enzyme BKN48_07930 ENOG4107104 thymidine kinase BKN48_07935 ENOG41082DI 50s ribosomal protein l31 BKN48_07940 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BKN48_07950 ENOG4105CBT Fructose-1,6-bisphosphatase BKN48_07955 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BKN48_07960 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway BKN48_07965 ENOG4105D2N Aldolase BKN48_07970 ENOG410812K response regulator receiver protein BKN48_07980 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BKN48_07990 ENOG4105C1G acyl-Coa dehydrogenase BKN48_07995 ENOG4105DF6 Fe-S oxidoreductase BKN48_08005 ENOG4105E5J UV damage endonuclease BKN48_08015 ENOG4105NAE bifunctional deaminase-reductase domain protein BKN48_08020 ENOG4105BZ1 (ABC) transporter BKN48_08025 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BKN48_08040 ENOG4105R3A Nitrate reductase BKN48_08045 ENOG4108IUE nitrate reductase beta subunit BKN48_08065 ENOG4107V6Q Cyclic nucleotide-binding domain BKN48_08075 ENOG4105C75 arginyL-tRNA synthetase BKN48_08080 ENOG410684U Domain of unknown function (DUF1934) BKN48_08090 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E BKN48_08140 ENOG4107JM4 Tetratricopeptide repeat BKN48_08155 ENOG4105CYW agmatinase BKN48_08160 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BKN48_08165 ENOG4105BZ4 penicillin-binding protein BKN48_08175 ENOG4108XFG YwhD family BKN48_08180 ENOG4108Z4T Peptidase M50 BKN48_08185 ENOG41069HH 4-oxalocrotonate tautomerase BKN48_08190 ENOG41067TZ transcriptional regulator, MarR family BKN48_08195 ENOG4105C22 threonyL-tRNA synthetase BKN48_08205 ENOG4105C57 major facilitator superfamily BKN48_08210 ENOG41062ES Transcriptional regulator BKN48_08220 ENOG4105DCI Phosphohydrolase BKN48_08230 ENOG4108VCI transcription factor, rsfa family BKN48_08235 ENOG4108RNG Permease of the drug metabolite transporter BKN48_08240 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BKN48_08245 ENOG4105DUM transcriptional regulator, lysR family BKN48_08250 ENOG4108IJ2 phosphate acetyltransferase BKN48_08265 ENOG4105CHM Aminotransferase BKN48_08275 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase BKN48_08280 ENOG4105CHR reductase BKN48_08285 ENOG4106CHD Bacilysin biosynthesis protein bacB BKN48_08290 ENOG41061WN bacilysin biosynthesis protein BKN48_08295 ENOG4105FCW Major Facilitator superfamily BKN48_08310 ENOG4105C26 Dehydrogenase BKN48_08315 ENOG4105D82 Glutamate dehydrogenase BKN48_08325 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BKN48_08330 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BKN48_08335 ENOG4105C1B dTDP-glucose 4-6-dehydratase BKN48_08340 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BKN48_08345 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BKN48_08350 ENOG4107TY6 Acylneuraminate cytidylyltransferase BKN48_08360 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BKN48_08365 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BKN48_08405 ENOG4105C26 Dehydrogenase BKN48_08410 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BKN48_08415 ENOG4108RJ9 Glycosyl transferase, family 2 BKN48_08435 ENOG4105DWF phosphomethylpyrimidine kinase BKN48_08450 ENOG4105C5Y PTS System BKN48_08455 ENOG4108QTI )-transporter BKN48_08470 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN48_08475 ENOG4105DEN Luciferase family BKN48_08480 ENOG4108DBC nitroreductase BKN48_08495 ENOG41060D1 Quinol oxidase BKN48_08500 ENOG4105CCU oxidase (Subunit III) BKN48_08505 ENOG4105BZ9 Cytochrome C oxidase, subunit I BKN48_08510 ENOG4105E2S oxidase) subunit II BKN48_08515 ENOG4107BMA Transglycosylase associated protein BKN48_08525 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BKN48_08530 ENOG4105WH5 Teichoic acid glycosylation protein BKN48_08555 ENOG4107ZXU DSBA oxidoreductase BKN48_08560 ENOG4105DBE peroxidase BKN48_08565 ENOG410650H (LipO)protein BKN48_08570 ENOG4107SJW iron permease, FTR1 BKN48_08575 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BKN48_08585 ENOG4105CMU LysR family (Transcriptional regulator BKN48_08590 ENOG4105VAW lrga family BKN48_08595 ENOG41067MG lrgb family BKN48_08600 ENOG4105D8G Major Facilitator superfamily BKN48_08610 ENOG4105DR4 Methyltransferase BKN48_08620 ENOG4108YV3 Protein of unknown function (DUF2711) BKN48_08625 ENOG4105CK1 PTS System BKN48_08630 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BKN48_08645 ENOG4105X1N Glycosyl transferase family 8 BKN48_08655 ENOG4105GVJ transcriptional regulator BKN48_08660 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BKN48_08665 ENOG4105IIU Aminopeptidase BKN48_08690 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BKN48_08705 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BKN48_08710 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BKN48_08720 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BKN48_08725 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BKN48_08730 ENOG4105CM2 brancheD-chain amino acid aminotransferase BKN48_08735 ENOG4105F8D glycoside hydrolase family 4 BKN48_08740 ENOG4105VCP PTS System BKN48_08745 ENOG4105CK1 PTS System BKN48_08750 ENOG4105VZJ PTS System BKN48_08755 ENOG4105EMD TRANSCRIPTIONal BKN48_08765 ENOG4108VX5 3-methyladenine DNA glycosylase BKN48_08770 ENOG4105CH6 catalase BKN48_08785 ENOG4105DA5 (ABC) transporter BKN48_08790 ENOG41069JR BKN48_08810 ENOG4105ETS cytosine purines uracil thiamine allantoin BKN48_08830 ENOG4105DY9 regulatoR BKN48_08855 ENOG4108JJ8 (ABC) transporter BKN48_08860 ENOG4108JJ9 ABC, transporter BKN48_08865 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BKN48_08870 ENOG4105C4M (Ubiquinol oxidase) subunit I BKN48_08875 ENOG4105D2K citrate carrier protein BKN48_08890 ENOG4107BJW polysaccharide deacetylase BKN48_08920 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BKN48_08930 ENOG4105CMR udp-glucose 4-epimerase BKN48_08940 ENOG4105BZU Histidine kinase BKN48_08945 ENOG4105WH1 Two component transcriptional regulator luxr family BKN48_08950 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BKN48_08980 ENOG4105DTD Dehydrogenase BKN48_08985 ENOG4108IIH CoA-transferase subunit B BKN48_08990 ENOG4105D6N CoA-transferase, subunit a BKN48_08995 ENOG4105CY2 Citrate transporter BKN48_09005 ENOG4105DHI Methyltransferase BKN48_09025 ENOG4105CH6 catalase BKN48_09030 ENOG4105D4T Citrate transporter BKN48_09035 ENOG4108RZ2 Glycoside hydrolase family 16 BKN48_09040 ENOG4105CID antiterminator BKN48_09050 ENOG4105DEU major facilitator superfamily BKN48_09055 ENOG4105C1J atp-dependent rna helicase BKN48_09060 ENOG4107TDE lipolytic protein G-D-S-L family BKN48_09120 ENOG4107YZX Universal stress protein BKN48_09125 ENOG4105CS2 ec 3.2.1.21 BKN48_09130 ENOG4105C5Y PTS System BKN48_09140 ENOG4107EV6 Inherit from COG: YD repeat protein BKN48_09155 ENOG4106Z5D Glycoside Hydrolase Family 43 BKN48_09170 ENOG4105C84 Histidine ammonia-lyase BKN48_09175 ENOG4105CGP Urocanate hydratase BKN48_09180 ENOG4105CI2 imidazolone-5-propionate hydrolase BKN48_09185 ENOG4107W25 arginase agmatinase formiminoglutamase BKN48_09195 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BKN48_09200 ENOG4105D9N nucleoside BKN48_09210 ENOG4107RHR regulatoR BKN48_09215 ENOG4108TM9 integral membrane protein BKN48_09220 ENOG4105ENY Ethanolamine utilization protein eutH BKN48_09225 ENOG4108PGP mmge prpd family protein BKN48_09230 ENOG4105CH2 amidohydrolase BKN48_09240 ENOG4108HW4 amino acid AbC transporter BKN48_09245 ENOG4105EAB amino acid AbC transporter BKN48_09250 ENOG4108XSB acetyltransferase, (GNAT) family BKN48_09255 ENOG4105CPU Monooxygenase BKN48_09260 ENOG4107QHE Choloylglycine hydrolase BKN48_09265 ENOG410667J hydrolase BKN48_09295 ENOG4108V5C ABC transporter BKN48_09325 ENOG4105D2N Aldolase BKN48_09330 ENOG4107TRN Xylose isomerase domain protein TIM barrel BKN48_09335 ENOG4105F0H myo-inositol catabolism protein BKN48_09340 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BKN48_09350 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BKN48_09355 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BKN48_09360 ENOG4105D7K pfkb domain protein BKN48_09370 ENOG4105C26 Dehydrogenase BKN48_09380 ENOG4105CPC Aldo Keto reductase BKN48_09410 ENOG4107QNK )-transporter BKN48_09415 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BKN48_09425 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BKN48_09430 ENOG4105ST3 Transcriptional regulator BKN48_09435 ENOG4105C26 Dehydrogenase BKN48_09445 ENOG4108ITS PQQ enzyme repeat BKN48_09455 ENOG41085PJ rdd domain containing protein BKN48_09470 ENOG4105J7D transcriptional regulator BKN48_09475 ENOG4107JEE Short-chain dehydrogenase reductase Sdr BKN48_09480 ENOG41061AU MarR family Transcriptional regulator BKN48_09490 ENOG41067MG lrgb family BKN48_09500 ENOG4105BZW Glycerate kinase BKN48_09505 ENOG4105G3Z GntR family transcriptional regulator BKN48_09510 ENOG4105CMG Carbohydrate kinase BKN48_09515 ENOG4105C6Z Gluconate BKN48_09520 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BKN48_09525 ENOG4105D3R alkyl hydroperoxide reductase BKN48_09530 ENOG4108JU3 Alkyl hydroperoxide reductase BKN48_09540 ENOG4105CS2 ec 3.2.1.21 BKN48_09550 ENOG4108S3Y transcriptional regulator BKN48_09560 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BKN48_09605 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BKN48_09620 ENOG4105E2A Dehydrogenase BKN48_09640 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BKN48_09645 ENOG4105WQG acetyltransferase BKN48_09650 ENOG410780I phosphoprotein phosphatase activity BKN48_09660 ENOG41066UZ arginase EC 3.5.3.1 BKN48_09665 ENOG4108IQI permease BKN48_09670 ENOG4105C8Y Acetylornithine aminotransferase BKN48_09675 ENOG4108JUB Transcriptional regulator BKN48_09685 ENOG4105C0H protease BKN48_09690 ENOG4105Q2H domain protein BKN48_09705 ENOG4105BZU Histidine kinase BKN48_09710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN48_09735 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BKN48_09740 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BKN48_09745 ENOG4105CDU Replicative dna helicase BKN48_09770 ENOG4105DJ2 Major Facilitator Superfamily BKN48_09775 ENOG4105EDW glycosyl transferase, family 39 BKN48_09780 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BKN48_09785 ENOG4105BZR domain protein BKN48_09790 ENOG4108XMW Membrane BKN48_09805 ENOG4105KVH Transcriptional regulator BKN48_09810 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BKN48_09830 ENOG41090E6 transcriptional regulator MERR family BKN48_09840 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein BKN48_09845 ENOG4105DDN Pentapeptide repeat-containing protein BKN48_09850 ENOG4105D94 Major Facilitator Superfamily BKN48_09855 ENOG4107RSM transcriptional regulator BKN48_09860 ENOG41082BV acetyltransferase BKN48_09865 ENOG41081I9 integral membrane protein BKN48_09875 ENOG4108U05 Transcriptional regulator BKN48_09880 ENOG41082BV acetyltransferase BKN48_09905 ENOG4105WAB arsR family transcriptional regulator BKN48_09925 ENOG4105C7Z Conserved Protein BKN48_09930 ENOG4107FCW Abortive infection protein BKN48_09940 ENOG4108UW5 maltose o-acetyltransferase BKN48_09945 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BKN48_09955 ENOG4105CGK Exodeoxyribonuclease III BKN48_09960 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BKN48_09965 ENOG4108UUM single-stranded DNA-binding protein BKN48_09970 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BKN48_09975 ENOG4105C3G gtp-binding protein BKN48_09980 ENOG4108J2R molybdopterin oxidoreductase BKN48_09985 ENOG4105VDK protein, conserved in bacteria BKN48_09995 ENOG4108ZDA Sporulation protein YyaC BKN48_10000 ENOG4105FA0 parb-like partition protein BKN48_10005 ENOG4107QJE Chromosome Partitioning Protein BKN48_10020 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BKN48_10025 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BKN48_10030 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BKN48_10045 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BKN48_10055 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BKN48_10060 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BKN48_10065 ENOG410848D S4 domain protein YaaA BKN48_10080 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BKN48_10085 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BKN48_10120 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BKN48_10130 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BKN48_10135 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BKN48_10140 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BKN48_10150 ENOG4105ZMH deoxynucleoside kinase BKN48_10160 ENOG4105VRS hydrolase family 18 BKN48_10165 ENOG4105GTG Isochorismatase BKN48_10170 ENOG4108Z6B deaminase BKN48_10180 ENOG4105C6E dna polymerase iii BKN48_10185 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BKN48_10190 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BKN48_10200 ENOG41067KS pro-sigma K processing BKN48_10240 ENOG4105CDW Resistance protein BKN48_10245 ENOG4105CXN decarboxylase BKN48_10250 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BKN48_10255 ENOG4105X0R protein from nitrogen regulatory protein P-II BKN48_10260 ENOG4105XVJ Protein of unknown function (DUF327) BKN48_10265 ENOG4105FA2 dna polymerase iii BKN48_10270 ENOG4105MA4 psp1 domain protein BKN48_10275 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BKN48_10280 ENOG41060K3 Methyltransferase BKN48_10285 ENOG4105VC4 domain protein BKN48_10290 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BKN48_10295 ENOG4105KRN Transcriptional regulator, abrb family BKN48_10300 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BKN48_10305 ENOG4105F8V Hydrolase, tatD family BKN48_10310 ENOG41069ER domain protein BKN48_10320 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BKN48_10325 ENOG4105XFA sporulation peptidase YabG BKN48_10330 ENOG4105W42 Veg protein BKN48_10335 ENOG4105XEW small acid-soluble spore protein BKN48_10340 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BKN48_10345 ENOG4105DFT pur operon repressor BKN48_10350 ENOG4105KME endoribonuclease L-psp BKN48_10355 ENOG4105K4W Could be involved in septation (By similarity) BKN48_10365 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BKN48_10370 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BKN48_10375 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BKN48_10380 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BKN48_10390 ENOG4108JA2 transcriptioN-repair coupling factor BKN48_10395 ENOG4108M14 stage v sporulation protein t BKN48_10405 ENOG4108IY2 MazG family BKN48_10410 ENOG41082I2 s4 domain protein BKN48_10415 ENOG4105VYY sporulation protein yabp BKN48_10430 ENOG41060GV RNA binding s1 domain protein BKN48_10460 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BKN48_10465 ENOG4108UGV hypoxanthine phosphoribosyltransferase BKN48_10470 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BKN48_10480 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BKN48_10485 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BKN48_10490 ENOG4105C6T cysteine synthase BKN48_10495 ENOG4105CRQ synthase (Component I) BKN48_10500 ENOG4105DDQ anthranilate synthase BKN48_10505 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BKN48_10510 ENOG4105EEI dihydropteroate synthase BKN48_10515 ENOG4105KRF dihydroneopterin aldolase BKN48_10520 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BKN48_10530 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BKN48_10535 ENOG4105CRK lysyL-tRNA synthetase BKN48_10620 ENOG4108Z0C Uvrb UvrC protein BKN48_10625 ENOG41066A3 ATP guanido phosphotransferase BKN48_10635 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BKN48_10640 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BKN48_10645 ENOG4105CTP PilT protein domain protein BKN48_10650 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BKN48_10655 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BKN48_10660 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BKN48_10670 ENOG4105D7W serine acetyltransferase BKN48_10675 ENOG4105C8N cysteinyl-tRNA synthetase BKN48_10680 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BKN48_10685 ENOG4105C2N RNA methyltransferase TrmH family group 3 BKN48_10690 ENOG4105M0M Tetracycline resistance protein BKN48_10710 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BKN48_10715 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BKN48_10725 ENOG4108VZM 50s ribosomal protein L10 BKN48_10730 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BKN48_10735 ENOG4107Y49 methyltransferase BKN48_10740 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BKN48_10745 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BKN48_10750 ENOG4105XPM ribosomal protein BKN48_10755 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BKN48_10760 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BKN48_10765 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BKN48_10770 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BKN48_10775 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BKN48_10780 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BKN48_10785 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BKN48_10790 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BKN48_10795 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BKN48_10800 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BKN48_10805 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BKN48_10810 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BKN48_10815 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BKN48_10820 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BKN48_10825 ENOG41082SA 50s ribosomal protein l29 BKN48_10830 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BKN48_10835 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BKN48_10845 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BKN48_10855 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BKN48_10860 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BKN48_10865 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BKN48_10870 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BKN48_10875 ENOG4105VPB 50S ribosomal protein L30 BKN48_10880 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BKN48_10885 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BKN48_10895 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BKN48_10905 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BKN48_10915 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BKN48_10920 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BKN48_10925 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BKN48_10930 ENOG4108ZT0 50S ribosomal protein l17 BKN48_10935 ENOG4108JJB ABC transporter BKN48_10940 ENOG4108JJB ABC transporter BKN48_10945 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BKN48_10950 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BKN48_10955 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BKN48_10960 ENOG4108UJD 30S ribosomal protein S9 BKN48_10965 ENOG4108I0C methyltransferase BKN48_10980 ENOG4105D1F ATP-binding protein BKN48_10995 ENOG4108NMV polysaccharide deacetylase BKN48_11080 ENOG4105CHH sulfate transporter BKN48_11095 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BKN48_11100 ENOG4108J59 Extracellular solute-binding protein, family 5 BKN48_11105 ENOG4105D06 uba thif-type nad fad binding protein BKN48_11110 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BKN48_11115 ENOG4107RDB Major Facilitator BKN48_11140 ENOG410874W AraC family transcriptional regulator BKN48_11145 ENOG4105EHZ conserved protein UCP016719 BKN48_11150 ENOG4105D17 glycoside hydrolase, family 3 domain protein BKN48_11170 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BKN48_11180 ENOG4105EWC Purine nucleoside phosphorylase BKN48_11210 ENOG4105EMN RNA polymerase sigma factor BKN48_11220 ENOG4105C8B TIGR00159 family BKN48_11225 ENOG4107U5W ybbr family BKN48_11230 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BKN48_11235 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BKN48_11240 ENOG4108TWJ NADH dehydrogenase subunit 5 BKN48_11260 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BKN48_11265 ENOG4105WAB arsR family transcriptional regulator BKN48_11270 ENOG4108RWP Major Facilitator Superfamily protein BKN48_11305 ENOG4105G0J serine threonine protein kinase BKN48_11315 ENOG4106K80 BKN48_11325 ENOG4106DDH Sporulation-specific SASP protein BKN48_11335 ENOG4108HWY Beta-lactamase BKN48_11340 ENOG4107E6A Cytochrome p-450 BKN48_11350 ENOG4107QTZ amino acid BKN48_11355 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BKN48_11360 ENOG4105CXY transporter BKN48_11370 ENOG410645S MarR family Transcriptional regulator BKN48_11375 ENOG4105DCM major facilitator superfamily BKN48_11390 ENOG410631K Membrane BKN48_11395 ENOG4106AXJ AraC family transcriptional regulator BKN48_11400 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BKN48_11405 ENOG4108TCS Glutamyl endopeptidase BKN48_11415 ENOG4108WC5 Alpha Beta Hydrolase Fold protein BKN48_11420 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BKN48_11425 ENOG4107ZTW SNARE associated Golgi BKN48_11445 ENOG4105C72 UPF0176 protein BKN48_11455 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane BKN48_11460 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BKN48_11465 ENOG4108X79 transcriptional regulator BKN48_11475 ENOG4105CM2 brancheD-chain amino acid aminotransferase BKN48_11480 ENOG4108IQI permease BKN48_11485 ENOG4108J5H Homocysteine s-methyltransferase BKN48_11500 ENOG4105CSV Glutaminase BKN48_11515 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase BKN48_11520 ENOG4105C26 Dehydrogenase BKN48_11525 ENOG4105DJB Major Facilitator Superfamily BKN48_11530 ENOG4105EQX glucarate dehydratase BKN48_11535 ENOG41073TP transcriptional regulator BKN48_11540 ENOG4105CTX dehydratase BKN48_11560 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BKN48_11595 ENOG4105MUA Resistance protein BKN48_11605 ENOG4105DGI Alkaline phosphatase BKN48_11610 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BKN48_11615 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BKN48_11620 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BKN48_11625 ENOG4107EPV Aminotransferase class V BKN48_11630 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN48_11635 ENOG4105J7D transcriptional regulator BKN48_11640 ENOG4107RB3 L-asparaginase BKN48_11645 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BKN48_11655 ENOG41060AI SEC-C motif BKN48_11665 ENOG4107Y7X LytTR BKN48_11670 ENOG4108IUW ABC transporter BKN48_11675 ENOG4108SDH ABC, transporter BKN48_11680 ENOG4107SET aldo keto reductase BKN48_11710 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BKN48_11720 ENOG4105DSE periplasmic solute binding protein BKN48_11725 ENOG4105DIK (ABC) transporter BKN48_11735 ENOG4105DEN Luciferase family BKN48_11740 ENOG4108N0M stress protein BKN48_11745 ENOG4106FN3 tellurium resistance protein BKN48_11750 ENOG4106FN3 tellurium resistance protein BKN48_11755 ENOG4107TS3 membrane protein, TerC BKN48_11760 ENOG4108TTB tellurium resistance protein BKN48_11770 ENOG41079KZ Major Facilitator Superfamily BKN48_11780 ENOG4108A65 Transcriptional regulator BKN48_11785 ENOG4108IJ7 Glycine betaine BKN48_11790 ENOG4107SQ8 Glycine betaine BKN48_11825 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BKN48_11860 ENOG4105EIG urea carboxylase-associated protein 1 BKN48_11865 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BKN48_11870 ENOG4105I1F Resistance protein BKN48_11875 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BKN48_11880 ENOG41089UC methyltransferase, type 11 BKN48_11885 ENOG4105C5Q Transcriptional regulator BKN48_11890 ENOG4105I82 acetyl xylan esterase BKN48_11895 ENOG410756H nucleotidyltransferase BKN48_11905 ENOG4105C26 Dehydrogenase BKN48_11910 ENOG4105CK7 Sodium proline symporter BKN48_11915 ENOG4107YHD transcriptional regulator BKN48_11925 ENOG4108PJD permease BKN48_11930 ENOG4105U6C Alpha beta hydrolase fold protein BKN48_11940 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BKN48_11945 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BKN48_11950 ENOG4108IFG nitrite reductase, (NAD(P)H) BKN48_11955 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BKN48_11975 ENOG4105S7A ErfK ybiS ycfS ynhG family protein BKN48_11985 ENOG4105CKI cobalamin synthesis protein BKN48_11990 ENOG4105E5Q amino acid AbC transporter BKN48_11995 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein BKN48_12005 ENOG4105HHM rdd domain containing protein BKN48_12015 ENOG4105CS2 ec 3.2.1.21 BKN48_12030 ENOG4105C8Q Methyl-accepting chemotaxis BKN48_12035 ENOG41080HJ 6-phospho 3-hexuloisomerase BKN48_12040 ENOG4108VA3 3-hexulose-6-phosphate synthase BKN48_12045 ENOG4105KVH Transcriptional regulator BKN48_12055 ENOG4105CEY Amp-dependent synthetase and ligase BKN48_12085 ENOG4105SX7 Transporter BKN48_12095 ENOG4105W8Z 4'-phosphopantetheinyl transferase BKN48_12105 ENOG4105CDA abc transporter atp-binding protein BKN48_12110 ENOG4105DRP amino acid AbC transporter BKN48_12120 ENOG4106P55 Transcriptional regulator BKN48_12125 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BKN48_12130 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BKN48_12135 ENOG41069ZX BKN48_12140 ENOG41069ZX BKN48_12150 ENOG4105DUX Transporter BKN48_12165 ENOG4105E1K spore germination protein BKN48_12185 ENOG4107WD8 ABC transporter, permease BKN48_12190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN48_12195 ENOG4105BZU Histidine kinase BKN48_12215 ENOG4105CFH Aspartokinase BKN48_12220 ENOG4105DHS permease protein BKN48_12225 ENOG4105CM4 permease protein BKN48_12230 ENOG4108IPW abc transporter atp-binding protein BKN48_12245 ENOG4105R8C Transcriptional regulator BKN48_12250 ENOG4108DBC nitroreductase BKN48_12255 ENOG41067V3 Antibiotic biosynthesis monooxygenase BKN48_12260 ENOG4105YVS arsR family transcriptional regulator BKN48_12270 ENOG4108JPW Aminotransferase BKN48_12275 ENOG4105C26 Dehydrogenase BKN48_12285 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BKN48_12290 ENOG4105KTB nuclear export factor GLE1 BKN48_12295 ENOG4108T5E Copper resistance protein BKN48_12300 ENOG4108ZYE Transcriptional regulator BKN48_12325 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BKN48_12330 ENOG4108ZX0 Signal peptidase I BKN48_12355 ENOG4105E7W lamb ycsf family protein BKN48_12360 ENOG4105C5A transporter BKN48_12365 ENOG4105CFM UPF0317 protein BKN48_12370 ENOG4105P4J Allophanate hydrolase, subunit 1 BKN48_12380 ENOG4107258 Transcriptional regulator BKN48_12385 ENOG4105XJB lipolytic protein G-D-S-L family BKN48_12395 ENOG41061CK Antibiotic biosynthesis monooxygenase BKN48_12400 ENOG4107RVG penicillin-binding protein BKN48_12405 ENOG4107QM2 Aldo Keto reductase BKN48_12410 ENOG4105ETD TRANSCRIPTIONal BKN48_12420 ENOG4105HMZ Methyltransferase BKN48_12425 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BKN48_12440 ENOG410606W general stress protein BKN48_12450 ENOG4105VCH membrane BKN48_12460 ENOG4105C9U ATP-dependent DNA helicase RecQ BKN48_12475 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BKN48_12480 ENOG4107R8N Glycosyl transferase, family 2 BKN48_12490 ENOG4105C0X amino acid BKN48_12515 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BKN48_12525 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BKN48_12530 ENOG4105EU9 BKN48_12535 ENOG4105QVS general stress protein BKN48_12540 ENOG41082W1 Cupin 2, conserved barrel domain protein BKN48_12555 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BKN48_12560 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BKN48_12565 ENOG4108MRH transcriptional regulatory protein BKN48_12570 ENOG4107QJT sodium dicarboxylate symporter BKN48_12575 ENOG4106F5Q Membrane BKN48_12585 ENOG4105CJ1 ABC, transporter BKN48_12600 ENOG4105FDT acyl-CoA dehydrogenase BKN48_12620 ENOG4105SZ6 Thioredoxin BKN48_12625 ENOG4105CPF Cell wall formation (By similarity) BKN48_12630 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BKN48_12635 ENOG4105C1J atp-dependent rna helicase BKN48_12640 ENOG410905X membrane-flanked domain protein BKN48_12645 ENOG4105CKV Membrane BKN48_12655 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BKN48_12660 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BKN48_12665 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BKN48_12675 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BKN48_12680 ENOG4107MMM Anti-sigma-factor antagonist BKN48_12685 ENOG4105FUA antagonist BKN48_12690 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BKN48_12695 ENOG4107SGM protein serine threonine phosphatase BKN48_12700 ENOG4105WN5 stage II sporulation protein BKN48_12705 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BKN48_12715 ENOG41064BQ Phosphatase BKN48_12730 ENOG4105M5P UPF0310 protein BKN48_12735 ENOG4105RV9 Transcriptional regulator BKN48_12805 ENOG4105DEN Luciferase family BKN48_12820 ENOG4108W2Y isochorismatase BKN48_12825 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BKN48_12830 ENOG4108HH4 Major Facilitator Superfamily BKN48_12835 ENOG4106ANW SMI1_KNR4 BKN48_12865 ENOG4105VEQ Cold shock protein BKN48_12870 ENOG4108VJ1 Transcriptional regulator (CarD family BKN48_12875 ENOG4108MCI Transcriptional regulator, ARAC family BKN48_12880 ENOG4108UZ3 Transporter BKN48_12885 ENOG41086D8 Transcriptional regulator BKN48_12890 ENOG4107U9B transcriptional regulator BKN48_12895 ENOG4105DXI Major Facilitator superfamily BKN48_12905 ENOG4105CZ9 Domain of unknown function (DU1801) BKN48_12910 ENOG4105GIG BKN48_12915 ENOG4105T38 integral membrane protein BKN48_12920 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BKN48_12925 ENOG4108ZMQ domain protein BKN48_12930 ENOG4105MJ9 esterase BKN48_12935 ENOG4107Z6X Transcriptional regulator BKN48_12945 ENOG41082YX Transcriptional regulator, arsr family BKN48_12950 ENOG4107R5R arsenical pump membrane protein BKN48_12960 ENOG4105Z7P Acetyltransferase (GNAT) family BKN48_12965 ENOG4108KGH TRANSCRIPTIONal BKN48_12970 ENOG4108ZJ4 polysaccharide deacetylase BKN48_12980 ENOG4105US7 Histidine kinase BKN48_12985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN48_12990 ENOG4107Y9U Membrane BKN48_13000 ENOG4108SQ9 flavin reductase domain protein, FMN-binding BKN48_13005 ENOG4108ZHR arsR family transcriptional regulator BKN48_13010 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BKN48_13020 ENOG4105ENE Histidine kinase BKN48_13025 ENOG4108VB1 regulatoR BKN48_13030 ENOG4105EYF MMPL domain protein BKN48_13035 ENOG4108UQV Membrane BKN48_13040 ENOG4108Z5V transcriptional regulator, merr family BKN48_13045 ENOG41076HS cation diffusion facilitator family transporter BKN48_13050 ENOG4108TVJ Nitroreductase BKN48_13055 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BKN48_13060 ENOG4108VGI doxx family BKN48_13065 ENOG4105XXY Thioredoxin BKN48_13090 ENOG4108QY0 Membrane BKN48_13110 ENOG4105PF9 Transcriptional regulator BKN48_13120 ENOG4105WQG acetyltransferase BKN48_13130 ENOG4105C85 amino acid BKN48_13140 ENOG41062A4 Transcriptional regulator BKN48_13145 ENOG4105EYF MMPL domain protein BKN48_13150 ENOG4108TVJ Nitroreductase BKN48_13155 ENOG4105FS7 Transcriptional regulator BKN48_13160 ENOG4105C2C drug resistance transporter, Bcr CflA BKN48_13170 ENOG4105DRR Transcriptional regulator, GntR family BKN48_13175 ENOG4105VRS hydrolase family 18 BKN48_13190 ENOG4105G6Z alkaline phosphatase BKN48_13195 ENOG4108ZMX Domain of unknown function (DU1801) BKN48_13205 ENOG4108YM7 Gcn5-related n-acetyltransferase BKN48_13210 ENOG4107TVP HD domain protein BKN48_13215 ENOG41090UD (LipO)protein BKN48_13220 ENOG4105F27 Major Facilitator BKN48_13225 ENOG4105VZJ PTS System BKN48_13230 ENOG4105VCP PTS System BKN48_13235 ENOG4105CK1 PTS System BKN48_13240 ENOG4105CS2 ec 3.2.1.21 BKN48_13245 ENOG4108TZY GntR Family Transcriptional Regulator BKN48_13250 ENOG4105EVU fructokinase BKN48_13255 ENOG4105DG6 mannose-6-phosphate isomerase BKN48_13260 ENOG4105D3P Mannan endo-1,4-beta-mannosidase BKN48_13305 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BKN48_13310 ENOG4105K8N protein family UPF0079, ATPase BKN48_13315 ENOG41072GX Peptidase M22 Glycoprotease BKN48_13320 ENOG410801F ribosomal-protein-alanine acetyltransferase BKN48_13325 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BKN48_13330 ENOG4105C5H ABC transporter BKN48_13335 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BKN48_13340 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BKN48_13345 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BKN48_13350 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BKN48_13360 ENOG4108TYN CAAX amino terminal protease family protein BKN48_13365 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BKN48_13370 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BKN48_13410 ENOG4105PGZ NB-ARC domain BKN48_13415 ENOG4105CPQ Dehydrogenase BKN48_13420 ENOG4105CT4 transporter BKN48_13430 ENOG41087YS Phage shock protein A BKN48_13435 ENOG4105DQX Zinc finger domain BKN48_13440 ENOG4108WV1 Pfam:DUF477 BKN48_13450 ENOG4108ZMR Ion transport 2 domain-containing protein BKN48_13455 ENOG4107QNK )-transporter BKN48_13485 ENOG4107YUH hydrolase BKN48_13495 ENOG4107STQ Multicopper oxidase BKN48_13500 ENOG4105C85 amino acid BKN48_13515 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BKN48_13545 ENOG4105C7N Xanthine uracil vitamin C permease BKN48_13570 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BKN48_13575 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BKN48_13580 ENOG4105C83 adenylosuccinate lyase BKN48_13585 ENOG4105C8V SAICAR synthetase BKN48_13590 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BKN48_13595 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BKN48_13600 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BKN48_13610 ENOG4105CXB phosphoribosylaminoimidazole synthetase BKN48_13615 ENOG4108V3E phosphoribosylglycinamide formyltransferase BKN48_13620 ENOG4105DC1 bifunctional purine biosynthesis protein purh BKN48_13625 ENOG4105C12 Phosphoribosylglycinamide synthetase BKN48_13635 ENOG4105DVH amino acid BKN48_13650 ENOG4108R5T secreted protein BKN48_13655 ENOG4105KGF protein, YerC YecD BKN48_13660 ENOG4105CBC glutamate synthase BKN48_13670 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BKN48_13675 ENOG4105C4R Atp-dependent dna helicase BKN48_13680 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BKN48_13690 ENOG4105CRN Aminoglycoside phosphotransferase BKN48_13695 ENOG4105KT7 mgtC SapB transporter BKN48_13700 ENOG4105CK7 Sodium proline symporter BKN48_13705 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BKN48_13710 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BKN48_13715 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BKN48_13720 ENOG4108IG5 Transcriptional regulator BKN48_13730 ENOG4105CBD Diacylglycerol kinase BKN48_13735 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BKN48_13765 ENOG4108HFV BKN48_13790 ENOG4105CDY transcriptional regulatory protein BKN48_13800 ENOG4105M4P Tetr family transcriptional regulator BKN48_13805 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein BKN48_13810 ENOG4107S9F NmrA family BKN48_13825 ENOG4105WEF catalase BKN48_13830 ENOG4105M18 -acetyltransferase BKN48_13845 ENOG4105C2F Histidine kinase BKN48_13850 ENOG4105EQD regulatoR BKN48_13855 ENOG410769Z extracellular solute-binding protein family 1 BKN48_13860 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BKN48_13865 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component BKN48_13870 ENOG4105F5H Glycosyl Hydrolase Family 88 BKN48_13875 ENOG41075H3 AraC family transcriptional regulator BKN48_13880 ENOG4107TDE lipolytic protein G-D-S-L family BKN48_13895 ENOG4105CX8 fg-gap repeat protein BKN48_13900 ENOG4105CX8 fg-gap repeat protein BKN48_13905 ENOG4107TDE lipolytic protein G-D-S-L family BKN48_13915 ENOG4105EKC BKN48_13920 ENOG4105E0S extracellular solute-binding protein family 1 BKN48_13930 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BKN48_13935 ENOG4105F8D glycoside hydrolase family 4 BKN48_13940 ENOG4105H67 Protein of unknown function (DUF421) BKN48_13945 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BKN48_13950 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BKN48_13970 ENOG4106I4J membrane BKN48_13975 ENOG41082F9 transcriptional regulator BKN48_13980 ENOG41061H0 Monooxygenase BKN48_13990 ENOG4108R1P BKN48_13995 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BKN48_14000 ENOG4105E0M Sulfatase BKN48_14005 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BKN48_14015 ENOG41090R9 glycosyltransferase BKN48_14020 ENOG4107R51 Glycosyl transferase, family 2 BKN48_14025 ENOG41090R9 glycosyltransferase BKN48_14030 ENOG4105EU0 Major facilitator Superfamily BKN48_14040 ENOG4105CUB amino acid BKN48_14045 ENOG4105C26 Dehydrogenase BKN48_14050 ENOG4105FKZ Methyl-accepting chemotaxis BKN48_14055 ENOG4105C5H ABC transporter BKN48_14065 ENOG4107SWG transcriptional regulator MERR family BKN48_14070 ENOG4105DXB Major Facilitator superfamily BKN48_14075 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN48_14090 ENOG4105C5H ABC transporter BKN48_14095 ENOG4105FDU atp-dependent rna helicase BKN48_14105 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BKN48_14110 ENOG4105E0A ABC, transporter BKN48_14115 ENOG4108U1V ABC transporter, permease BKN48_14120 ENOG4105DQ5 transport system permease protein BKN48_14125 ENOG4108HUF Transporter BKN48_14140 ENOG4108J20 pectate lyase BKN48_14145 ENOG4107QPK )-transporter BKN48_14155 ENOG4108MRH transcriptional regulatory protein BKN48_14185 ENOG410855V Acylphosphatase BKN48_14190 ENOG4108RPX mosc domain containing protein BKN48_14210 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BKN48_14235 ENOG4105GEU Spore germination protein BKN48_14245 ENOG4108Q5U germination protein, ger(x)c family BKN48_14250 ENOG4105E1K spore germination protein BKN48_14255 ENOG4105C5Y PTS System BKN48_14260 ENOG4105CG3 alpha amylase, catalytic region BKN48_14265 ENOG4107414 GntR family transcriptional regulator BKN48_14270 ENOG4108RCM Nitroreductase BKN48_14275 ENOG4105CGH 5'-nucleotidase BKN48_14280 ENOG4107RKG DJ-1/PfpI family BKN48_14295 ENOG4105KJF protein tyrosine phosphatase BKN48_14305 ENOG4107U9T Pfam:Ribonuclease_BN BKN48_14315 ENOG4108ISG Major Facilitator BKN48_14325 ENOG4105UPD Calcium Proton BKN48_14335 ENOG4105D8X mechanosensitive ion channel BKN48_14355 ENOG4106KE4 Dehydrogenase BKN48_14360 ENOG4105D7N magnesium and cobalt transport protein CorA BKN48_14370 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BKN48_14395 ENOG4107RUY (E1 component), alpha subunit BKN48_14405 ENOG4107QKR Dehydrogenase BKN48_14415 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BKN48_14420 ENOG41069DP small acid-soluble spore protein BKN48_14425 ENOG4105KK4 UPF0060 membrane protein BKN48_14455 ENOG4105F8D glycoside hydrolase family 4 BKN48_14460 ENOG4108Q3X Transcriptional regulator BKN48_14465 ENOG4105CI1 PTS System BKN48_14475 ENOG4105BZ1 (ABC) transporter BKN48_14485 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BKN48_14490 ENOG4105BZU Histidine kinase BKN48_14495 ENOG4105WH1 Two component transcriptional regulator luxr family BKN48_14500 ENOG4105CJ1 ABC, transporter BKN48_14505 ENOG41090VJ ABC-2 type transporter BKN48_14510 ENOG4108KYE ABC-2 type transporter BKN48_14515 ENOG4105U3E Transcriptional regulator BKN48_14520 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BKN48_14525 ENOG4105H93 Acyltransferase family BKN48_14530 ENOG4108YYS metal-dependent hydrolase (By similarity) BKN48_14535 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN48_14540 ENOG410834F Transcriptional regulator BKN48_14550 ENOG4108MES Periplasmic binding protein BKN48_14555 ENOG4105DQ5 transport system permease protein BKN48_14560 ENOG4108IHU transport system permease protein BKN48_14565 ENOG4105JAB phenazine biosynthesis protein, phzf family BKN48_14570 ENOG4107Y03 Nitroreductase BKN48_14585 ENOG4105ECP epimerase BKN48_14605 ENOG4105F27 Major Facilitator BKN48_14625 ENOG4106AKJ BKN48_14630 ENOG4105D74 hydrolase BKN48_14635 ENOG4105CKK Glycosyl transferase, family 2 BKN48_14640 ENOG4105EJV Membrane BKN48_14645 ENOG41067AE Membrane-bound metal-dependent hydrolase BKN48_14650 ENOG4105CEN a g-specific adenine glycosylase BKN48_14655 ENOG4106BXE BKN48_14660 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BKN48_14675 ENOG4105EVI UPF0374 protein BKN48_14680 ENOG4105BZ1 (ABC) transporter BKN48_14685 ENOG4107NBY Membrane BKN48_14695 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BKN48_14700 ENOG4105G5W regulator Fur family BKN48_14815 ENOG4108N23 SpoOM-related protein BKN48_14830 ENOG4105EC3 peptidase S51, dipeptidase E BKN48_14835 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BKN48_14850 ENOG4105E2Y ABC, transporter BKN48_14855 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BKN48_14860 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BKN48_14865 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BKN48_14875 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BKN48_14880 ENOG4107D63 BKN48_14885 ENOG4105VZ8 Transcriptional regulator BKN48_14900 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BKN48_14910 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BKN48_14930 ENOG4105CYN Serine protein kinase BKN48_14935 ENOG4106AKX UPF0229 protein BKN48_14945 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BKN48_14950 ENOG4105CW7 secretion protein, HlyD family BKN48_14955 ENOG4105C0R drug resistance transporter emrb qaca subfamily BKN48_14960 ENOG4105CS1 NAD(P)H quinone oxidoreductase BKN48_14975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BKN48_14990 ENOG4105VEQ Cold shock protein BKN48_15000 ENOG4105BZU Histidine kinase BKN48_15055 ENOG4108YBP pseudouridine synthase BKN48_15065 ENOG41080XP Cbs domain BKN48_15070 ENOG4107YBY Hydrolase BKN48_15075 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BKN48_15080 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BKN48_15085 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BKN48_15095 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BKN48_15100 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BKN48_15110 ENOG4105BZU Histidine kinase BKN48_15115 ENOG4105WH1 Two component transcriptional regulator luxr family BKN48_15150 ENOG4105ED1 spovr family BKN48_15155 ENOG4105G6Z alkaline phosphatase BKN48_15170 ENOG4105BZN citrate synthase BKN48_15175 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BKN48_15180 ENOG4105CUB amino acid BKN48_15185 ENOG4105C8J )-transporter BKN48_15190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BKN48_15205 ENOG4105J37 BKN48_15210 ENOG4108AEY RNA polymerase sigma factor BKN48_15215 ENOG4108FN7 Aldo keto reductase BKN48_15220 ENOG4105F6E Acyl-transferase BKN48_15225 ENOG4105C37 (CBS) domain BKN48_15235 ENOG4105CHM Aminotransferase BKN48_15240 ENOG4105C37 (CBS) domain BKN48_15250 ENOG4105WMR Protein CrcB homolog BKN48_15255 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BKN48_15265 ENOG4105D64 Mechanosensitive ion channel BKN48_15270 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BKN48_15275 ENOG4107VMI polysaccharide deacetylase BKN48_15280 ENOG4105F0I Aminotransferase BKN48_15300 ENOG4105BZ1 (ABC) transporter BKN48_15305 ENOG4105BZ1 (ABC) transporter BKN48_15325 ENOG410839P BKN48_15335 ENOG4106MP8 UPF0754 membrane protein BKN48_15340 ENOG4105WZB UPF0342 protein BKN48_15345 ENOG4105F1N DNA alkylation repair BKN48_15355 ENOG4105D4P Coproporphyrinogen iii oxidase BKN48_15360 ENOG4107S91 Sodium hydrogen exchanger BKN48_15365 ENOG4105NCW Trka-c domain protein BKN48_15375 ENOG4105CGU Enoyl-CoA hydratase BKN48_15385 ENOG4108IUX (ABC) transporter BKN48_15390 ENOG4105RHA ABC transporter, permease BKN48_15400 ENOG4107VRP DNA repair exonuclease BKN48_15405 ENOG4106D4I domain protein BKN48_15410 ENOG4105EQI Metal Dependent Phosphohydrolase BKN48_15420 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BKN48_15455 ENOG4105NBU tryptophan transport protein BKN48_15460 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BKN48_15465 ENOG4105K59 histidine triad (HIT) protein BKN48_15500 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BKN48_15505 ENOG4105BZ4 penicillin-binding protein BKN48_15510 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BKN48_15515 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BKN48_15520 ENOG4105C1Q protoporphyrinogen oxidase BKN48_15530 ENOG4105ECB domain protein BKN48_15540 ENOG41090T1 Membrane BKN48_15550 ENOG4105DER m42 family BKN48_15565 ENOG4106AXD BKN48_15570 ENOG4108RQ5 Beta-lactamase domain-containing protein BKN48_15575 ENOG4105DF9 Lipoate-protein, ligase BKN48_15585 ENOG4105CEY Amp-dependent synthetase and ligase BKN48_15595 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BKN48_15605 ENOG4105KD7 acetyltransferase BKN48_15615 ENOG4108HUF Transporter BKN48_15620 ENOG4107TB6 phosphoglycerate mutase BKN48_15630 ENOG4107F3J Amp-dependent synthetase and ligase BKN48_15635 ENOG4107ZYJ bioY protein BKN48_15640 ENOG4106YBV Methyl-accepting chemotaxis BKN48_15660 ENOG4105XVF Competence transcription factor BKN48_15665 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BKN48_15670 ENOG4105X3H Excalibur domain protein BKN48_15675 ENOG4105E1V na solute symporter BKN48_15680 ENOG4106CAD Protein of unknown function (DUF3311) BKN48_15685 ENOG41060YP BKN48_15700 ENOG4107SCK Monooxygenase BKN48_15705 ENOG4108INS Transcriptional regulator BKN48_15730 ENOG4105TRI Hydrolase BKN48_15745 ENOG4108KK1 membrane protein AbrB duplication BKN48_15750 ENOG4106K7D Major facilitator family transporter BKN48_15755 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BKN48_15760 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding BKN48_15775 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BKN48_15785 ENOG4105EYH Exonuclease BKN48_15840 ENOG4105ERH Fumarylacetoacetate hydrolase BKN48_15850 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN48_15860 ENOG4105CAQ asparagine synthetase BKN48_15875 ENOG4105UQX Mate efflux family protein BKN48_15880 ENOG4106HBX Transcriptional Regulator AraC Family BKN48_15885 ENOG4105ETE Transcriptional regulator (LacI family BKN48_15890 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BKN48_15895 ENOG4105SF0 DinB family BKN48_15900 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BKN48_15910 ENOG4105MYW Pentapeptide repeat protein BKN48_15915 ENOG4107S9D Alpha beta hydrolase BKN48_15920 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BKN48_15925 ENOG4107RIQ Sulfate adenylate transferase BKN48_15930 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BKN48_15935 ENOG4108N5B 2-phosphosulfolactate phosphatase BKN48_15940 ENOG41061P3 phosphosulfolactate synthase BKN48_15950 ENOG4105DIA mandelate racemase muconate lactonizing BKN48_15955 ENOG4107RCC Major Facilitator Superfamily BKN48_15960 ENOG4108SZE gCN5-related N-acetyltransferase BKN48_15965 ENOG4105MA6 gCN5-related N-acetyltransferase BKN48_15975 ENOG4108VPT UPF0234 protein BKN48_15980 ENOG4105QNR S1 RNA binding domain protein BKN48_16000 ENOG4105K7K Transcriptional regulator BKN48_16010 ENOG410751J BKN48_16015 ENOG4105D4Y metalloprotease BKN48_16020 ENOG4105EPR degv family BKN48_16025 ENOG4107AYK membrAne BKN48_16035 ENOG41073B9 BKN48_16045 ENOG4108KP7 hydrolase BKN48_16050 ENOG4108MXZ Esterase BKN48_16055 ENOG4105VG1 fes assembly suf system protein BKN48_16065 ENOG4105IQ5 FAD linked oxidase domain protein BKN48_16075 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BKN48_16090 ENOG4105C8Y Acetylornithine aminotransferase BKN48_16095 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BKN48_16105 ENOG4105DBV ornithine carbamoyltransferase BKN48_16130 ENOG4107RMD Basic membrane lipoprotein BKN48_16145 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BKN48_16150 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BKN48_16160 ENOG4105C3U ABC transporter BKN48_16165 ENOG4108JQ7 (ABC) transporter BKN48_16180 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN48_16190 ENOG4105C31 Tryptophanyl-tRNA synthetase BKN48_16195 ENOG4108J59 Extracellular solute-binding protein, family 5 BKN48_16200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BKN48_16205 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN48_16215 ENOG4108JQ7 (ABC) transporter BKN48_16230 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BKN48_16235 ENOG4108ZCF integral membrane protein BKN48_16240 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BKN48_16250 ENOG4105DPN Oligoendopeptidase f BKN48_16265 ENOG4105T58 Dithiol-disulfide isomerase BKN48_16270 ENOG4108Z18 K06886 hemoglobin BKN48_16275 ENOG4105E4C Lytic transglycosylase catalytic BKN48_16280 ENOG4105MIX Adenylate cyclase BKN48_16295 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BKN48_16300 ENOG4105EMS pseudouridine synthase BKN48_16315 ENOG4105ETU transcriptional activator (TenA BKN48_16320 ENOG4108VEU Thiamine monophosphate synthase BKN48_16335 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BKN48_16340 ENOG4105D06 uba thif-type nad fad binding protein BKN48_16345 ENOG4105DWF phosphomethylpyrimidine kinase BKN48_16350 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BKN48_16355 ENOG4107A88 BKN48_16410 ENOG4105ENA helicase BKN48_16425 ENOG4108ZMI UPF0477 protein BKN48_16435 ENOG4105C28 cystathionine BKN48_16440 ENOG4105C28 cystathionine BKN48_16445 ENOG4105D9U N-acetyltransferase BKN48_16450 ENOG4105JHY Membrane BKN48_16470 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BKN48_16480 ENOG4106BHF BKN48_16510 ENOG4108PSK reductase BKN48_16525 ENOG4105DM4 PTS System BKN48_16530 ENOG4105DG6 mannose-6-phosphate isomerase BKN48_16535 ENOG4105G7B Protein of unknown function (DUF2992) BKN48_16540 ENOG4105VMI -acetyltransferase BKN48_16550 ENOG4108Z66 YbaK ebsC protein BKN48_16565 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BKN48_16575 ENOG4108ZJ4 polysaccharide deacetylase BKN48_16580 ENOG4107CUJ Protein of unknown function (DUF2690) BKN48_16610 ENOG4108IEG Formate dehydrogenase Alpha subunit BKN48_16635 ENOG4106A3M Cytochrome p-450 BKN48_16640 ENOG41087PP glycosyltransferase MGT family BKN48_16650 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BKN48_16655 ENOG4105C4B ABC transporter, permease BKN48_16660 ENOG4108IXI (ABC) transporter BKN48_16670 ENOG4105Q95 Cupin 2, conserved barrel domain protein BKN48_16685 ENOG4105D2H Uronic isomerase BKN48_16690 ENOG4105CT4 transporter BKN48_16695 ENOG4105DG4 malate L-lactate dehydrogenase BKN48_16700 ENOG4105CPQ Dehydrogenase BKN48_16705 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BKN48_16710 ENOG4105DMW Dehydrogenase reductase BKN48_16715 ENOG4108I5G Major Facilitator superfamily BKN48_16720 ENOG4107KJX Transcriptional regulator BKN48_16725 ENOG4107QZW Altronate oxidoreductase BKN48_16730 ENOG4105CTX dehydratase BKN48_16735 ENOG4107TSN permease BKN48_16745 ENOG4105JD4 ATPase yjob BKN48_16760 ENOG41068K0 YCII-related domain BKN48_16765 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BKN48_16770 ENOG4105KWG Pfam:DUF1696 BKN48_16775 ENOG4105K7W phage-related replication protein BKN48_16780 ENOG4105WEF catalase BKN48_16785 ENOG410635T phage-like element pbsx protein BKN48_16835 ENOG4108TFU terminase (Small subunit) BKN48_16840 ENOG4105IG6 Phage terminase, large subunit BKN48_16845 ENOG4108MDF Phage Portal Protein BKN48_16870 ENOG41060SN BKN48_16885 ENOG4105PQS phage protein BKN48_16890 ENOG4105FR7 XkdM protein, phage-like element PBSX BKN48_16895 ENOG4105MTC XkdN-like protein BKN48_16905 ENOG4108FKH Transglycosylase SLT domain BKN48_16905 ENOG4108FKH Transglycosylase SLT domain BKN48_16910 ENOG4108WZM domain protein BKN48_16915 ENOG4105X7F BKN48_16925 ENOG4105MFU Protein of unknown function (DUF2634) BKN48_16930 ENOG41066EA baseplate J family protein BKN48_16935 ENOG410906S phage-like element pbsx protein xkdt BKN48_16945 ENOG41068G1 BKN48_16975 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BKN48_16990 ENOG4105CJ3 phosphate transporter BKN48_16995 ENOG4107GRR phosphate transport regulator BKN48_17000 ENOG4107R7I amino acid BKN48_17010 ENOG4105EDW glycosyl transferase, family 39 BKN48_17015 ENOG4105CKK Glycosyl transferase, family 2 BKN48_17025 ENOG4105C0H protease BKN48_17035 ENOG4108ME1 Peptidase M55 D-aminopeptidase BKN48_17040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BKN48_17045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BKN48_17050 ENOG4105C3U ABC transporter BKN48_17060 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BKN48_17065 ENOG4105DTQ mandelate racemase muconate lactonizing BKN48_17070 ENOG4107SN7 NLP P60 protein BKN48_17075 ENOG4108JQ7 (ABC) transporter BKN48_17080 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BKN48_17085 ENOG4107TUM Amidinotransferase BKN48_17090 ENOG4108S4H thioesterase Superfamily protein BKN48_17095 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BKN48_17115 ENOG4108428 Inherit from COG: -acetyltransferase BKN48_17125 ENOG41080TC multidrug resistance protein BKN48_17130 ENOG4105CIY formyltetrahydrofolate deformylase BKN48_17135 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BKN48_17150 ENOG4105K56 Transcriptional regulator BKN48_17155 ENOG4108ZHJ Organic hydroperoxide resistance protein BKN48_17165 ENOG4107Y2X deaminase BKN48_17170 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BKN48_17175 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN48_17185 ENOG4108W7F transporter, permease BKN48_17190 ENOG4108JJB ABC transporter BKN48_17195 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BKN48_17200 ENOG4108X43 YKOF domain protein BKN48_17205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BKN48_17210 ENOG41062D9 Histidine kinase BKN48_17220 ENOG4106849 propeptide, pepSY amd peptidase M4 BKN48_17240 ENOG4105CJW magnesium transporter BKN48_17245 ENOG4105V75 Transcriptional regulator BKN48_17290 ENOG4105DQE DNA ligase BKN48_17295 ENOG4105FDF Could be involved in DNA repair (By similarity) BKN48_17300 ENOG4105BZU Histidine kinase BKN48_17305 ENOG4107T5V SNARE associated Golgi BKN48_17310 ENOG4107TS3 membrane protein, TerC BKN48_17315 ENOG4108WZW RNA polymerase sigma BKN48_17325 ENOG410681C small acid-soluble spore protein BKN48_17335 ENOG4105D0M Protease HtpX homolog BKN48_17355 ENOG4108TGC Acyltransferase BKN48_17360 ENOG4105BZU Histidine kinase BKN48_17365 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BKN48_17375 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BKN48_17380 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BKN48_17385 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BKN48_17395 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit BKN48_17400 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BKN48_17405 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BKN48_17410 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BKN48_17430 ENOG4105BZU Histidine kinase BKN48_17435 ENOG41090MY MarR family Transcriptional regulator BKN48_17440 ENOG4105ER2 Ompa motb domain protein BKN48_17445 ENOG4105E14 MotA TolQ exbB proton channel BKN48_17455 ENOG4108K88 Membrane BKN48_17460 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BKN48_17465 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BKN48_17470 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BKN48_17475 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BKN48_17485 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BKN48_17490 ENOG4105FEA Spore maturation protein BKN48_17525 ENOG4105F0V Cell wall hydrolase BKN48_17540 ENOG4105C59 p-type ATPase BKN48_17550 ENOG4105DC7 peptidase M24 BKN48_17565 ENOG4105CID antiterminator BKN48_17575 ENOG4105KRI phosphocarrier protein (HPr BKN48_17580 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BKN48_17590 ENOG4105F6S Spore photoproduct lyase BKN48_17600 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BKN48_17605 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BKN48_17610 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid BKN48_17615 ENOG4105K4I Scp-like extracellular BKN48_17625 ENOG4105BZU Histidine kinase BKN48_17630 ENOG4105CHM Aminotransferase BKN48_17640 ENOG4107R88 Chemotaxis protein (CheV) BKN48_17645 ENOG4105UIN BKN48_17655 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BKN48_17665 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BKN48_17670 ENOG4105EPM Diguanylate phosphodiesterase BKN48_17680 ENOG4107IN1 Protein of unknown function (DUF1797) BKN48_17685 ENOG4108XRC Protein of unknown function (DUF458) BKN48_17715 ENOG4105NQC Flavodoxin BKN48_17725 ENOG4105CH2 amidohydrolase BKN48_17735 ENOG4105D8X mechanosensitive ion channel BKN48_17740 ENOG4105D3R alkyl hydroperoxide reductase BKN48_17745 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BKN48_17760 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BKN48_17765 ENOG4105D06 uba thif-type nad fad binding protein BKN48_17770 ENOG4105CVM Molybdenum cofactor synthesis domain protein BKN48_17775 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BKN48_17780 ENOG4108ZAF Molybdopterin BKN48_17785 ENOG41067WU Molybdopterin converting factor (Subunit 1) BKN48_17790 ENOG4105BZ1 (ABC) transporter BKN48_17795 ENOG4105BZ1 (ABC) transporter BKN48_17805 ENOG4107X8C Efflux transporter RND family MFP subunit BKN48_17810 ENOG4105C19 ABC transporter BKN48_17815 ENOG4107RBB ABC transporter, permease BKN48_17820 ENOG4105E98 transcriptional regulator DeoR family BKN48_17825 ENOG4105DE4 1-phosphofructokinase BKN48_17830 ENOG4105DM4 PTS System BKN48_17835 ENOG4105C3F Signal peptidase i BKN48_17845 ENOG4105C5H ABC transporter BKN48_17850 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BKN48_17875 ENOG4105BZU Histidine kinase BKN48_17885 ENOG4107ZYR domain protein BKN48_17895 ENOG4105CN5 Metallo-Beta-Lactamase BKN48_17905 ENOG4108X4Q Hydrolase BKN48_17910 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BKN48_17930 ENOG4105CPP Dehydrogenase, E1 component BKN48_17935 ENOG4105C7S Dehydrogenase BKN48_17940 ENOG4107QN2 dihydrolipoyl dehydrogenase BKN48_17950 ENOG4105CXN decarboxylase BKN48_17955 ENOG4105WBI UPF0223 protein BKN48_17970 ENOG4105ECY inositol monophosphatase BKN48_17980 ENOG4105JQZ Methyltransferase BKN48_18020 ENOG4105CI3 gtp-binding protein typa BKN48_18025 ENOG4105QA2 BKN48_18040 ENOG4108IAB Phoh family BKN48_18050 ENOG4105CSV Glutaminase BKN48_18055 ENOG4105ZPI UPF0358 protein BKN48_18060 ENOG4105CNI cell division protein FtsW BKN48_18065 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BKN48_18075 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BKN48_18085 ENOG4105BZ9 Cytochrome C oxidase, subunit I BKN48_18090 ENOG4105CCU oxidase (Subunit III) BKN48_18095 ENOG41064X9 cytochrome C oxidase subunit IV BKN48_18110 ENOG41080XQ Signal transduction protein with cbs domains BKN48_18115 ENOG4106UY4 Inherit from COG: Scp-like extracellular BKN48_18135 ENOG4105WUC UPF0298 protein BKN48_18140 ENOG4106H78 methyltransferase BKN48_18145 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BKN48_18150 ENOG4105H20 Sporulation integral membrane protein YlbJ BKN48_18155 ENOG4105D78 K07001 NTE family protein BKN48_18160 ENOG41063PX domain protein BKN48_18165 ENOG4105CDE UPF0348 protein BKN48_18175 ENOG4105KNH Nucleic acid-binding protein BKN48_18180 ENOG41067VY 50S ribosomal protein L32 BKN48_18205 ENOG4108V6E Cell division protein mraZ BKN48_18210 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BKN48_18220 ENOG4105CJN penicillin-binding protein BKN48_18230 ENOG4105CJN penicillin-binding protein BKN48_18240 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BKN48_18250 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BKN48_18255 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BKN48_18260 ENOG4105CNI cell division protein FtsW BKN48_18265 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BKN48_18270 ENOG4105D4A Cell wall formation (By similarity) BKN48_18275 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BKN48_18280 ENOG4108R2U division initiation protein BKN48_18290 ENOG4105K67 small basic protein BKN48_18295 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BKN48_18300 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BKN48_18310 ENOG4105FFI sigma-e processing peptidase spoiiga BKN48_18315 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BKN48_18325 ENOG4105DKW ABC transporter BKN48_18335 ENOG4105WR5 sporulation protein, YlmC YmxH family BKN48_18340 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BKN48_18345 ENOG4105DFA alanine racemase domain protein BKN48_18350 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BKN48_18355 ENOG41067XK integral membrane protein BKN48_18360 ENOG4105DBK s4 domain protein BKN48_18370 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BKN48_18380 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BKN48_18385 ENOG4105C34 Pseudouridine synthase BKN48_18390 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BKN48_18400 ENOG4105CXT aspartate transcarbamylase BKN48_18410 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BKN48_18415 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BKN48_18420 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BKN48_18425 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BKN48_18430 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BKN48_18435 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BKN48_18440 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BKN48_18450 ENOG4107S4M Sulfate adenylate transferase BKN48_18455 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BKN48_18460 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BKN48_18465 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BKN48_18470 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BKN48_18475 ENOG4105F23 Fibronectin-binding protein BKN48_18485 ENOG4105DSJ YicC domain protein BKN48_18490 ENOG4105KC4 UPF0296 protein BKN48_18495 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BKN48_18505 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BKN48_18510 ENOG4105C25 Primosomal protein n' BKN48_18515 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BKN48_18520 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BKN48_18525 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BKN48_18530 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BKN48_18535 ENOG4108ZF3 Phosphatase BKN48_18540 ENOG4105D9P serine threonine protein kinase BKN48_18545 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BKN48_18550 ENOG4105DJV ribulose-phosphate 3-epimerase BKN48_18555 ENOG4105FJ0 thiamine BKN48_18565 ENOG4105VB9 50S ribosomal protein l28 BKN48_18570 ENOG4108ZAA Alkaline-shock protein BKN48_18575 ENOG4105DP4 dak2 domain fusion protein ylov BKN48_18585 ENOG4105EJQ L-serine dehydratase BKN48_18590 ENOG4105CB5 ATP-dependent DNA helicase recG BKN48_18595 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BKN48_18605 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BKN48_18610 ENOG4105CHR reductase BKN48_18615 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BKN48_18620 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BKN48_18625 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BKN48_18630 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BKN48_18640 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BKN48_18650 ENOG4105K5M 30s ribosomal protein S16 BKN48_18655 ENOG4108BW8 UPF0109 protein BKN48_18665 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BKN48_18670 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BKN48_18675 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BKN48_18680 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BKN48_18685 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BKN48_18695 ENOG4105VM1 flagellar BKN48_18700 ENOG4105CMV Succinyl-CoA synthetase subunit beta BKN48_18705 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BKN48_18710 ENOG4105C79 DNA protecting protein DprA BKN48_18715 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BKN48_18720 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BKN48_18725 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BKN48_18730 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BKN48_18735 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BKN48_18745 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BKN48_18750 ENOG4108ZC9 flagellar basal-body rod protein flgc BKN48_18755 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BKN48_18760 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BKN48_18765 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BKN48_18780 ENOG4106YF4 Flagellar biosynthesis chaperone BKN48_18790 ENOG410696Y Flagellar hook-length control protein BKN48_18795 ENOG410822I Flagellar hook capping protein BKN48_18800 ENOG4108JQA flagellar BKN48_18805 ENOG41068WV flagellar FlbD family protein BKN48_18815 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BKN48_18820 ENOG4105DD5 Flagellar motor switch protein BKN48_18825 ENOG4107YTP response regulator receiver protein BKN48_18835 ENOG4105CN7 Flagellar biosynthetic protein FliP BKN48_18840 ENOG4105VS8 Flagellar biosynthetic protein fliq BKN48_18845 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BKN48_18850 ENOG4105D00 flagellar biosynthetic protein flhB BKN48_18855 ENOG4105D7B Flagellar biosynthesis protein flha BKN48_18860 ENOG4105FZW flagellar biosynthesis regulator FlhF BKN48_18870 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BKN48_18875 ENOG4105CBS Chea signal transduction histidine kinase BKN48_18880 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BKN48_18895 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BKN48_18905 ENOG4105CE9 30S ribosomal protein S2 BKN48_18910 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BKN48_18920 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BKN48_18925 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BKN48_18930 ENOG4105KNE Phosphatidate cytidylyltransferase BKN48_18940 ENOG4105DZP Membrane-associated zinc metalloprotease BKN48_18945 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BKN48_18950 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BKN48_18955 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BKN48_18960 ENOG4105CHV Transcription elongation factor NusA BKN48_18965 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BKN48_18970 ENOG4105VHM ribosomal protein BKN48_18975 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BKN48_18980 ENOG4105W7A Protein of unknown function (DUF503) BKN48_18985 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BKN48_18990 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BKN48_18995 ENOG4105DTN riboflavin biosynthesis protein ribF BKN48_19000 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BKN48_19005 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BKN48_19015 ENOG4105C1V Peptidase, M16 BKN48_19030 ENOG4105E35 Dipicolinate synthase subunit A BKN48_19035 ENOG4108S0H Dipicolinic acid synthetase, b subunit BKN48_19040 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BKN48_19050 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BKN48_19060 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BKN48_19070 ENOG4105CNU cell division protein FtsK BKN48_19075 ENOG4105FDP GntR family transcriptional regulator BKN48_19095 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BKN48_19100 ENOG4105XZV Protein of unknown function (DUF3243) BKN48_19115 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BKN48_19120 ENOG4105CEV competence damage-inducible protein BKN48_19130 ENOG4108A04 Beta-lactamase BKN48_19135 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BKN48_19140 ENOG4105D48 metallophosphoesterase BKN48_19145 ENOG4105MCT stage V sporulation protein S BKN48_19155 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BKN48_19160 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BKN48_19175 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BKN48_19180 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BKN48_19195 ENOG4105IIP Membrane BKN48_19200 ENOG4105W1N transcriptional regulator BKN48_19205 ENOG4108151 Beta-lactamase domain protein BKN48_19215 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BKN48_19225 ENOG4107QKG PfaD family BKN48_19230 ENOG41062T2 Acyl carrier protein BKN48_19235 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase BKN48_19240 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BKN48_19245 ENOG4108MGH Enoyl-CoA hydratase BKN48_19250 ENOG4108KQ6 Enoyl-CoA hydratase BKN48_19255 ENOG4105C0W non-ribosomal peptide synthetase BKN48_19260 ENOG4107SQU synthase BKN48_19270 ENOG4105C0W non-ribosomal peptide synthetase BKN48_19280 ENOG4106A3M Cytochrome p-450 BKN48_19295 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BKN48_19305 ENOG4105K7W phage-related replication protein BKN48_19310 ENOG4108X3M OsmC Ohr family protein BKN48_19315 ENOG410814C multidrug resistance protein BKN48_19335 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BKN48_19340 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BKN48_19355 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BKN48_19360 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BKN48_19365 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BKN48_19370 ENOG4105U6W MutT NUDIX family protein BKN48_19375 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BKN48_19380 ENOG4106F1P AAA ATPase, central domain protein BKN48_19390 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BKN48_19395 ENOG4105CXI aluminum resistance protein BKN48_19400 ENOG4105KV4 Transcriptional regulator BKN48_19405 ENOG4105C5F glutamine synthetase BKN48_19435 ENOG41079P0 BKN48_19485 ENOG410907G BKN48_19490 ENOG4105CT4 transporter BKN48_19495 ENOG4105DSG hydrolase family 43 BKN48_19500 ENOG4105E2R ROK family BKN48_19505 ENOG4105C93 Xylose Isomerase BKN48_19510 ENOG4105CMG Carbohydrate kinase BKN48_19515 ENOG4107Y9E nuclease BKN48_19520 ENOG4105C54 Major Facilitator superfamily BKN48_19525 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BKN48_19535 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BKN48_19600 ENOG4108Q8B Spore germination protein BKN48_19605 ENOG4108NHD germination protein BKN48_19620 ENOG4105FVX BKN48_19630 ENOG4105K7W phage-related replication protein BKN48_19640 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BKN48_19650 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BKN48_19660 ENOG4108SVB resolvase BKN48_19665 ENOG4105VPS UPF0291 protein BKN48_19670 ENOG4105CV1 Transketolase (EC 2.2.1.1) BKN48_19690 ENOG4107QIV Cytochrome c biogenesis protein BKN48_19715 ENOG4107DZX Small, acid-soluble spore protein P BKN48_19725 ENOG4108I0Z Aconitate hydratase BKN48_19730 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BKN48_19745 ENOG41067CD Small, acid-soluble spore protein Tlp BKN48_19755 ENOG4105MI2 BKN48_19760 ENOG4105W8X HesB YadR YfhF-family protein BKN48_19765 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BKN48_19770 ENOG4105K4P CoA-binding domain protein BKN48_19775 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BKN48_19800 ENOG4107QWR cellulase (EC 3.2.1.4) BKN48_19810 ENOG4108MYR Secreted protein BKN48_19815 ENOG4107SYN Glycosyl hydrolases family 43 BKN48_19825 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BKN48_19830 ENOG4107T5V SNARE associated Golgi BKN48_19840 ENOG4107QX3 carboxylase BKN48_19845 ENOG4105E39 Enoyl-CoA hydratase BKN48_19850 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BKN48_19855 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BKN48_19860 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BKN48_19865 ENOG4105CEY Amp-dependent synthetase and ligase BKN48_19870 ENOG4105C1G acyl-Coa dehydrogenase BKN48_19885 ENOG4105F32 YngK protein BKN48_19890 ENOG4106U2H Protein of unknown function (DUF1360) BKN48_19900 ENOG4105CEY Amp-dependent synthetase and ligase BKN48_19905 ENOG4105C0W non-ribosomal peptide synthetase BKN48_19915 ENOG4105C0W non-ribosomal peptide synthetase BKN48_19920 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BKN48_19925 ENOG4108N2V aldose 1-epimerase BKN48_19930 ENOG4107QJQ Mate efflux family protein BKN48_19955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BKN48_19960 ENOG4105SKE transcriptional Regulator LysR family BKN48_19965 ENOG4105CB2 alcohol dehydrogenase BKN48_19970 ENOG4105BZ8 glutamate synthase BKN48_19975 ENOG4105CBC glutamate synthase BKN48_19980 ENOG4105C5Q Transcriptional regulator BKN48_19985 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BKN48_19990 ENOG4105II7 pyrroline-5-carboxylate reductase BKN48_20010 ENOG4108UB7 BKN48_20015 ENOG41068WN BKN48_20020 ENOG4105IE8 Alpha-ketoglutarate permease BKN48_20025 ENOG4107U6E carbohydrate kinase FGGY BKN48_20030 ENOG4108M3J Dehydrogenase BKN48_20035 ENOG4108J2R molybdopterin oxidoreductase BKN48_20060 ENOG4105EC8 Methyl-accepting chemotaxis BKN48_20070 ENOG4108YQE rare lipoprotein a BKN48_20075 ENOG4105XPP Protein of unknown function (DUF1275) BKN48_20080 ENOG4108NR7 pectate lyase BKN48_20085 ENOG4108RAV Conserved protein BKN48_20095 ENOG4105F0F Oxalate decarboxylase BKN48_20105 ENOG4105EPI acetyltransferase, (GNAT) family BKN48_20120 ENOG41073R8 VanW family BKN48_20130 ENOG4105VMP Transcriptional regulator BKN48_20135 ENOG4105NX3 Membrane BKN48_20145 ENOG4108Q5Y Membrane BKN48_20155 ENOG4108V4B ThiJ pfpI BKN48_20160 ENOG4108J4B Beta-lactamase BKN48_20180 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BKN48_20185 ENOG4107T94 Endo-14-beta-xylanase BKN48_20195 ENOG4105YB8 TM2 domain containing protein BKN48_20225 ENOG4105CM2 brancheD-chain amino acid aminotransferase BKN48_20250 ENOG4107RGC Glycosyl transferase, family 2 BKN48_20255 ENOG4106WTF Glycosyl transferase, family 2 BKN48_20290 ENOG4108KU9 integrase family BKN48_20295 ENOG4108FPN Integrase BKN48_20320 ENOG4108Z7R Chaperone CsaA BKN48_20325 ENOG4105FTV AraC Family Transcriptional Regulator BKN48_20330 ENOG4108HJF gCN5-related N-acetyltransferase BKN48_20340 ENOG4108W8B Beta-lactamase domain protein BKN48_20350 ENOG4105D29 Helix-turn-helix type 11 domain protein BKN48_20360 ENOG4105KTU Transcriptional regulator, arsr family BKN48_20370 ENOG4108SJC Membrane BKN48_20390 ENOG4105ECK Fatty Acid Desaturase BKN48_20395 ENOG4108ZGX Histidine kinase BKN48_20400 ENOG4108S01 response regulator BKN48_20405 ENOG41069ER domain protein BKN48_20410 ENOG4105C9U ATP-dependent DNA helicase RecQ BKN48_20425 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BKN48_20430 ENOG4105SCY DNAK suppressor BKN48_20470 ENOG4105C26 Dehydrogenase BKN48_20475 ENOG4105EWU Squalene--hopene cyclase BKN48_20480 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BKN48_20485 ENOG4105C8J )-transporter BKN48_20490 ENOG4105C09 Bile acid BKN48_20495 ENOG4105C7S Dehydrogenase BKN48_20505 ENOG4107T89 von Willebrand factor, type A BKN48_20510 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BKN48_20520 ENOG4105K4H Nlp p60 protein