locus-tag	class	description
C663_0002	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C663_0003	COG0592	DNA-directed DNA polymerase activity
C663_0004	COG2501	S4 domain
C663_0005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C663_0007	COG0187	DNA topoisomerase II activity
C663_0008	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C663_0011	COG0517	IMP dehydrogenase activity
C663_0011	COG0516	GMP reductase activity
C663_0012	COG1686	Belongs to the peptidase S11 family
C663_0013	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C663_0014	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C663_0015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C663_0016	COG1428	Deoxynucleoside kinase
C663_0017	COG1428	Deoxynucleoside kinase
C663_0018	COG1388	LysM domain
C663_0018	COG3858	chitin binding
C663_0019	COG1335	isochorismatase
C663_0020	COG0590	tRNA wobble adenosine to inosine editing
C663_0021	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C663_0022	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C663_0023	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C663_0027	COG3853	Toxic anion resistance protein (TelA)
C663_0028	COG1982	Orn Lys Arg decarboxylase major
C663_0029	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C663_0030	COG3870	Protein conserved in bacteria
C663_0031	COG1728	Protein conserved in bacteria
C663_0032	COG0470	DNA polymerase III
C663_0033	COG1774	PSP1 C-terminal conserved region
C663_0034	COG4467	Involved in initiation control of chromosome replication
C663_0035	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C663_0036	COG2827	Endonuclease containing a URI domain
C663_0037	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C663_0038	COG2002	toxin-antitoxin pair type II binding
C663_0039	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C663_0039	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C663_0040	COG0084	hydrolase, TatD family'
C663_0041	COG3583	domain protein
C663_0041	COG3584	3D domain protein
C663_0042	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C663_0043	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C663_0045	COG4466	Protein conserved in bacteria
C663_0047	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C663_0048	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C663_0049	COG0251	oxidation-reduction process
C663_0050	COG2088	sporulation resulting in formation of a cellular spore
C663_0051	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C663_0052	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C663_0053	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C663_0054	COG0193	aminoacyl-tRNA hydrolase activity
C663_0056	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C663_0057	COG2002	toxin-antitoxin pair type II binding
C663_0058	COG2244	polysaccharide biosynthetic process
C663_0059	COG3956	TIGRFAM MazG family protein
C663_0060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C663_0063	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C663_0064	COG1098	S1 RNA binding domain
C663_0065	COG2208	phosphoserine phosphatase activity
C663_0066	COG2304	oxidoreductase activity
C663_0067	COG0515	serine threonine protein kinase
C663_0068	COG0037	tRNA processing
C663_0070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C663_0071	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C663_0072	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C663_0073	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C663_0074	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C663_0075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C663_0076	COG0512	Glutamine amidotransferase of anthranilate synthase
C663_0077	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C663_0078	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C663_0079	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C663_0080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C663_0081	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C663_0083	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C663_0084	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C663_0085	COG4463	regulation of RNA biosynthetic process
C663_0086	COG3880	PFAM UvrB UvrC protein
C663_0087	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C663_0088	COG0542	response to heat
C663_0089	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C663_0090	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C663_0091	COG4956	integral membrane protein (PIN domain superfamily)
C663_0092	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C663_0093	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C663_0094	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C663_0095	COG1045	serine acetyltransferase
C663_0096	COG0215	cysteine-tRNA ligase activity
C663_0097	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C663_0098	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C663_0099	COG3688	RNA-binding protein containing a PIN domain
C663_0100	COG1595	DNA-templated transcription, initiation
C663_0101	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C663_0102	COG0250	Participates in transcription elongation, termination and antitermination
C663_0103	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C663_0104	COG0081	regulation of translation
C663_0105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C663_0106	COG0222	ribosome binding
C663_0107	COG2813	Specifically methylates the guanine in position
C663_0108	COG0085	RNA polymerase activity
C663_0109	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C663_0110	COG1358	cellular component organization or biogenesis
C663_0111	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C663_0112	COG0049	tRNA binding
C663_0113	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C663_0114	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C663_0115	COG0596	Alpha beta hydrolase
C663_0116	COG0051	transcription antitermination factor activity, RNA binding
C663_0117	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C663_0118	COG0088	Forms part of the polypeptide exit tunnel
C663_0119	COG0089	rRNA binding
C663_0120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C663_0121	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C663_0122	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C663_0123	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C663_0124	COG0255	Belongs to the universal ribosomal protein uL29 family
C663_0125	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C663_0127	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C663_0129	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C663_0130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C663_0131	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C663_0133	COG1841	ribosomal large subunit assembly
C663_0134	COG0200	Binds to the 23S rRNA
C663_0135	COG0201	protein transport
C663_0136	COG0563	adenylate kinase activity
C663_0137	COG0024	Methionine aminopeptidase
C663_0138	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C663_0139	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C663_0140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C663_0141	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C663_0142	COG0202	RNA polymerase activity
C663_0143	COG0203	ribosomal protein L17
C663_0144	COG1122	ATPase activity
C663_0145	COG1122	ATPase activity
C663_0146	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C663_0147	COG0101	tRNA pseudouridine synthase activity
C663_0148	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C663_0149	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C663_0150	COG2226	methyltransferase
C663_0152	COG0860	N-Acetylmuramoyl-L-alanine amidase
C663_0153	COG0489	protein tyrosine kinase activity
C663_0155	COG2194	sulfuric ester hydrolase activity
C663_0156	COG0726	polysaccharide deacetylase
C663_0157	COG0659	secondary active sulfate transmembrane transporter activity
C663_0158	COG0385	Bile acid
C663_0159	COG2819	hydrolase of the alpha beta superfamily
C663_0160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C663_0161	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C663_0162	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C663_0163	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C663_0163	COG2207	Transcriptional regulator
C663_0164	COG3876	Protein conserved in bacteria
C663_0165	COG1472	Belongs to the glycosyl hydrolase 3 family
C663_0166	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C663_0167	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_0167	COG1263	PTS System
C663_0168	COG1737	Transcriptional regulator
C663_0169	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C663_0170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C663_0171	COG1683	Conserved Protein
C663_0172	COG1595	DNA-templated transcription, initiation
C663_0173	COG5662	AntiSigma factor
C663_0174	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C663_0175	COG4856	YbbR-like protein
C663_0176	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C663_0177	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C663_0180	COG3002	Belongs to the UPF0753 family
C663_0183	COG5609	conserved protein (DUF2294)
C663_0184	COG0640	Transcriptional regulator
C663_0186	COG2814	Major facilitator Superfamily
C663_0187	COG0596	Alpha beta hydrolase
C663_0188	COG0745	RESPONSE REGULATOR receiver
C663_0189	COG0642	Histidine kinase
C663_0191	COG0515	serine threonine protein kinase
C663_0194	COG1113	amino acid transport
C663_0197	COG2602	Beta-lactamase
C663_0198	COG2124	cytochrome p450
C663_0200	COG0531	amino acid
C663_0201	COG0584	glycerophosphoryl diester phosphodiesterase
C663_0202	COG2271	Major facilitator Superfamily
C663_0204	COG1846	Transcriptional regulator
C663_0204	COG0456	acetyltransferase
C663_0205	COG2271	Major facilitator Superfamily
C663_0207	COG0697	spore germination
C663_0208	COG2207	Transcriptional regulator
C663_0208	COG1917	Cupin 2, conserved barrel domain protein
C663_0209	COG1397	ADP-ribosylglycohydrolase
C663_0211	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C663_0212	COG3591	Belongs to the peptidase S1B family
C663_0214	COG0596	Alpha beta hydrolase
C663_0215	COG1183	phosphatidylcholine synthase activity
C663_0216	COG0586	Pfam SNARE associated Golgi protein
C663_0217	COG0688	phosphatidylethanolamine metabolic process
C663_0219	COG2312	Erythromycin esterase
C663_0221	COG1301	dicarboxylic acid transport
C663_0222	COG1263	PTS System
C663_0222	COG2190	(PTS) system
C663_0222	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_0224	COG0363	glucosamine-6-phosphate deaminase activity
C663_0227	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C663_0228	COG0833	amino acid
C663_0229	COG2040	homocysteine
C663_0231	COG1115	amino acid carrier protein
C663_0232	COG2066	Belongs to the glutaminase family
C663_0233	COG4191	Histidine kinase
C663_0234	COG0784	Response regulator, receiver
C663_0235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C663_0236	COG1012	belongs to the aldehyde dehydrogenase family
C663_0237	COG2271	Major facilitator Superfamily
C663_0238	COG4948	Mandelate Racemase Muconate Lactonizing
C663_0239	COG2186	Transcriptional regulator
C663_0240	COG2721	sulfolactate sulfo-lyase activity
C663_0241	COG3173	Aminoglycoside phosphotransferase
C663_0243	COG0697	spore germination
C663_0244	COG0745	RESPONSE REGULATOR receiver
C663_0245	COG2205	protein histidine kinase activity
C663_0246	COG1131	(ABC) transporter
C663_0250	COG3773	Cell wall hydrolase
C663_0251	COG2304	oxidoreductase activity
C663_0253	COG3540	Alkaline phosphatase
C663_0254	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C663_0255	COG0805	protein transport
C663_0256	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C663_0257	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C663_0258	COG0477	Major facilitator Superfamily
C663_0259	COG1309	transcriptional regulator
C663_0260	COG0252	asparaginase activity
C663_0261	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C663_0262	COG1714	RDD family
C663_0263	COG3012	SEC-C Motif Domain Protein
C663_0263	COG1405	negative regulation of cell septum assembly
C663_0265	COG3279	Response regulator of the LytR AlgR family
C663_0266	COG4555	ABC transporter
C663_0267	COG1668	transmembrane transport
C663_0268	COG0667	Aldo Keto reductase
C663_0270	COG1595	DNA-templated transcription, initiation
C663_0272	COG1876	peptidase activity
C663_0273	COG0457	Tetratricopeptide repeat
C663_0274	COG1028	Short-chain dehydrogenase reductase Sdr
C663_0275	COG0366	Alpha amylase catalytic
C663_0276	COG0803	Belongs to the bacterial solute-binding protein 9 family
C663_0278	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C663_0279	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C663_0280	COG2310	stress, protein
C663_0281	COG2310	stress, protein
C663_0282	COG0861	Integral membrane protein TerC family
C663_0284	COG3853	Toxic anion resistance protein (TelA)
C663_0285	COG0477	Major facilitator Superfamily
C663_0286	COG2814	Major facilitator Superfamily
C663_0287	COG0640	Transcriptional regulator
C663_0288	COG4175	Glycine betaine
C663_0288	COG0517	IMP dehydrogenase activity
C663_0289	COG4176	ABC-type proline glycine betaine transport system permease component
C663_0290	COG2113	Glycine betaine
C663_0291	COG1473	amidohydrolase
C663_0292	COG1288	antiporter activity
C663_0294	COG0366	Alpha amylase catalytic
C663_0295	COG0039	L-malate dehydrogenase activity
C663_0296	COG1620	l-lactate permease
C663_0297	COG2814	Major facilitator Superfamily
C663_0298	COG1846	Transcriptional regulator
C663_0299	COG1280	lysine exporter protein (LysE YggA)
C663_0300	COG3403	YqcI/YcgG family
C663_0301	COG1113	amino acid transport
C663_0302	COG3665	Urea carboxylase-associated protein
C663_0303	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C663_0304	COG1660	Displays ATPase and GTPase activities
C663_0305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C663_0306	COG2226	methyltransferase
C663_0307	COG0583	DNA-binding transcription factor activity
C663_0308	COG3458	cephalosporin-C deacetylase activity
C663_0309	COG3541	Predicted nucleotidyltransferase
C663_0310	COG0506	proline dehydrogenase activity
C663_0311	COG1012	belongs to the aldehyde dehydrogenase family
C663_0312	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C663_0313	COG2508	Transcriptional regulator
C663_0314	COG3689	TIGRFAM TIGR03943 family protein
C663_0315	COG0701	Predicted permease
C663_0316	COG2267	carboxylic ester hydrolase activity
C663_0317	COG0492	ferredoxin-NADP+ reductase activity
C663_0318	COG1587	Uroporphyrinogen-III synthase
C663_0318	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C663_0319	COG2146	nitrite reductase [NAD(P)H] activity
C663_0320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C663_0321	COG0243	molybdopterin cofactor binding
C663_0322	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C663_0323	COG2223	nitrite transmembrane transporter activity
C663_0324	COG1469	GTP cyclohydrolase I activity
C663_0325	COG1376	ErfK ybiS ycfS ynhG family protein
C663_0326	COG0523	cobalamin synthesis protein
C663_0327	COG0765	amino acid transport
C663_0328	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C663_0330	COG1714	RDD family
C663_0332	COG2723	6-phospho-beta-galactosidase activity
C663_0334	COG3209	COG3209 Rhs family protein
C663_0335	COG0840	transmembrane signaling receptor activity
C663_0335	COG3290	protein histidine kinase activity
C663_0336	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C663_0337	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C663_0338	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C663_0339	COG1733	regulation of RNA biosynthetic process
C663_0341	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_0342	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_0343	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_0344	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C663_0345	COG2814	Major facilitator Superfamily
C663_0347	COG0697	spore germination
C663_0348	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C663_0350	COG2364	Membrane
C663_0351	COG1126	abc transporter atp-binding protein
C663_0352	COG0765	amino acid transport
C663_0353	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C663_0354	COG0583	DNA-binding transcription factor activity
C663_0355	COG0163	prenyltransferase activity
C663_0356	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C663_0359	COG0596	Alpha beta hydrolase
C663_0360	COG3104	oligopeptide transport
C663_0361	COG5434	Belongs to the glycosyl hydrolase 28 family
C663_0363	COG0697	spore germination
C663_0365	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C663_0366	COG1136	(ABC) transporter
C663_0367	COG0577	efflux transmembrane transporter activity
C663_0368	COG0745	RESPONSE REGULATOR receiver
C663_0369	COG5002	protein histidine kinase activity
C663_0369	COG3850	Histidine kinase
C663_0370	COG0457	Tetratricopeptide repeat
C663_0372	COG0527	aspartate kinase activity
C663_0373	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C663_0374	COG4605	iron ion homeostasis
C663_0375	COG4604	ABC transporter, ATP-binding protein
C663_0376	COG4607	ABC-type enterochelin transport system periplasmic component
C663_0377	COG2814	Major facilitator Superfamily
C663_0378	COG1309	transcriptional regulator
C663_0379	COG0778	Nitroreductase
C663_0380	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C663_0381	COG0640	Transcriptional regulator
C663_0382	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C663_0383	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C663_0384	COG1012	belongs to the aldehyde dehydrogenase family
C663_0385	COG4975	Glucose uptake
C663_0386	COG1028	Short-chain dehydrogenase reductase Sdr
C663_0387	COG4549	nuclear export factor GLE1
C663_0388	COG1276	copper resistance
C663_0388	COG2372	response to copper ion
C663_0389	COG1349	DNA-binding transcription factor activity
C663_0391	COG2213	PTS system mannitol-specific
C663_0392	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C663_0394	COG0473	3-isopropylmalate dehydrogenase activity
C663_0395	COG0681	Belongs to the peptidase S26 family
C663_0396	COG0412	Dienelactone hydrolase
C663_0397	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C663_0399	COG0561	phosphatase activity
C663_0400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C663_0401	COG1914	H( )-stimulated, divalent metal cation uptake system
C663_0402	COG4336	lyase activity
C663_0403	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C663_0404	COG1984	allophanate hydrolase subunit 2
C663_0405	COG1414	Transcriptional regulator
C663_0406	COG2755	lipolytic protein G-D-S-L family
C663_0408	COG2329	Antibiotic biosynthesis monooxygenase
C663_0409	COG0768	penicillin binding
C663_0410	COG4989	oxidoreductase activity
C663_0411	COG3711	transcriptional antiterminator
C663_0412	COG0318	PFAM AMP-dependent synthetase and ligase
C663_0413	COG1028	Short-chain dehydrogenase reductase Sdr
C663_0414	COG1917	Cupin 2, conserved barrel domain protein
C663_0415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C663_0416	COG3871	stress protein (general stress protein 26)
C663_0418	COG2814	Major facilitator Superfamily
C663_0419	COG1522	sequence-specific DNA binding
C663_0420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C663_0420	COG0551	DNA topoisomerase type I activity
C663_0421	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C663_0422	COG3706	GGDEF domain
C663_0423	COG5298	Protein conserved in bacteria
C663_0424	COG1215	transferase activity, transferring glycosyl groups
C663_0426	COG0531	amino acid
C663_0427	COG0494	nUDIX hydrolase
C663_0428	COG0028	Belongs to the TPP enzyme family
C663_0431	COG1914	H( )-stimulated, divalent metal cation uptake system
C663_0432	COG2261	transglycosylase associated protein
C663_0433	COG4876	unkown
C663_0434	COG2217	Heavy metal translocating P-type atpase
C663_0435	COG3729	General stress protein
C663_0436	COG0662	Cupin 2, conserved barrel domain protein
C663_0437	COG2329	Antibiotic biosynthesis monooxygenase
C663_0438	COG3546	catalase activity
C663_0439	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C663_0440	COG3290	protein histidine kinase activity
C663_0441	COG4565	transcriptional regulatory protein
C663_0442	COG1301	dicarboxylic acid transport
C663_0443	COG0628	permease
C663_0445	COG1131	(ABC) transporter
C663_0446	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C663_0449	COG1960	acyl-CoA dehydrogenase activity
C663_0452	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C663_0453	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C663_0454	COG1181	Belongs to the D-alanine--D-alanine ligase family
C663_0455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C663_0456	COG0513	Belongs to the DEAD box helicase family
C663_0457	COG3402	PFAM membrane-flanked domain
C663_0458	COG3428	Bacterial PH domain
C663_0459	COG0705	Rhomboid family
C663_0460	COG0736	holo-[acyl-carrier-protein] synthase activity
C663_0461	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C663_0462	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C663_0463	COG0864	Transcriptional regulator
C663_0464	COG2337	Toxic component of a toxin-antitoxin (TA) module
C663_0465	COG1366	Belongs to the anti-sigma-factor antagonist family
C663_0466	COG1366	Belongs to the anti-sigma-factor antagonist family
C663_0467	COG2172	sigma factor antagonist activity
C663_0468	COG2208	phosphoserine phosphatase activity
C663_0469	COG1366	Belongs to the anti-sigma-factor antagonist family
C663_0470	COG2172	sigma factor antagonist activity
C663_0471	COG1191	sigma factor activity
C663_0472	COG2208	phosphoserine phosphatase activity
C663_0474	COG1673	EVE domain
C663_0475	COG1846	Transcriptional regulator
C663_0476	COG2183	response to ionizing radiation
C663_0478	COG3091	SprT-like family
C663_0480	COG0515	serine threonine protein kinase
C663_0484	COG0515	serine threonine protein kinase
C663_0485	COG1132	(ABC) transporter
C663_0487	COG3239	Fatty acid desaturase
C663_0488	COG1278	Cold shock
C663_0489	COG1329	Transcriptional regulator
C663_0490	COG1917	Cupin 2, conserved barrel domain protein
C663_0490	COG2207	Transcriptional regulator
C663_0491	COG0697	spore germination
C663_0492	COG2207	Transcriptional regulator
C663_0492	COG3708	Transcriptional regulator
C663_0493	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C663_0495	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C663_0497	COG0697	spore germination
C663_0498	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C663_0499	COG2030	dehydratase
C663_0500	COG3545	Serine hydrolase
C663_0501	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C663_0502	COG1733	regulation of RNA biosynthetic process
C663_0503	COG2249	NAD(P)H dehydrogenase (quinone) activity
C663_0504	COG2814	Major facilitator Superfamily
C663_0505	COG1309	transcriptional regulator
C663_0507	COG0640	Transcriptional regulator
C663_0508	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C663_0510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C663_0512	COG0726	polysaccharide deacetylase
C663_0514	COG5002	protein histidine kinase activity
C663_0516	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C663_0518	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C663_0519	COG0640	Transcriptional regulator
C663_0520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C663_0523	COG4585	Histidine kinase
C663_0524	COG2197	response regulator
C663_0525	COG2409	Drug exporters of the RND superfamily
C663_0526	COG0596	Alpha beta hydrolase
C663_0527	COG1811	Na channel or pump
C663_0528	COG0789	Transcriptional regulator
C663_0528	COG4978	Transcriptional regulator
C663_0529	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C663_0530	COG0778	Nitroreductase
C663_0531	COG0346	lactoylglutathione lyase activity
C663_0532	COG2259	Doxx family
C663_0533	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C663_0535	COG2323	membrane
C663_0536	COG2323	membrane
C663_0537	COG0071	Belongs to the small heat shock protein (HSP20) family
C663_0539	COG1309	transcriptional regulator
C663_0541	COG0456	acetyltransferase
C663_0546	COG1113	amino acid transport
C663_0547	COG1846	Transcriptional regulator
C663_0548	COG2409	Drug exporters of the RND superfamily
C663_0548	COG1033	growth of symbiont in host cell
C663_0549	COG0778	Nitroreductase
C663_0550	COG1846	Transcriptional regulator
C663_0551	COG2814	Major facilitator Superfamily
C663_0552	COG0730	response to heat
C663_0553	COG1802	Transcriptional regulator
C663_0554	COG3858	chitin binding
C663_0554	COG1388	LysM domain
C663_0555	COG1819	glycosyl
C663_0557	COG1785	Belongs to the alkaline phosphatase family
C663_0560	COG0454	-acetyltransferase
C663_0561	COG1078	dGTPase activity
C663_0562	COG1388	LysM domain
C663_0563	COG2814	Major facilitator Superfamily
C663_0564	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C663_0565	COG1447	Phosphotransferase system cellobiose-specific component IIA
C663_0566	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C663_0567	COG2723	6-phospho-beta-galactosidase activity
C663_0568	COG2188	Transcriptional regulator
C663_0569	COG1940	carbohydrate kinase activity
C663_0570	COG1482	cell wall glycoprotein biosynthetic process
C663_0571	COG4124	Belongs to the glycosyl hydrolase 26 family
C663_0573	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C663_0574	COG0802	atpase or kinase
C663_0575	COG1214	PFAM Peptidase M22, glycoprotease
C663_0576	COG0456	acetyltransferase
C663_0577	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C663_0578	COG0488	(ABC) transporter
C663_0579	COG0315	cyclic pyranopterin monophosphate synthase activity
C663_0580	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C663_0581	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C663_0582	COG0805	protein transport
C663_0584	COG1266	CAAX protease self-immunity
C663_0585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C663_0586	COG0459	protein refolding
C663_0587	COG2856	Zn peptidase
C663_0588	COG1396	sequence-specific DNA binding
C663_0594	COG5377	YqaJ viral recombinase family
C663_0595	COG3723	Recombinational DNA repair protein, rece pathway
C663_0596	COG3935	DnaD domain protein
C663_0597	COG1484	DNA-dependent DNA replication
C663_0604	COG3677	Transposase
C663_0606	COG5484	DNA packaging
C663_0623	COG5632	N-Acetylmuramoyl-L-alanine amidase
C663_0623	COG1388	LysM domain
C663_0623	COG3409	Peptidoglycan-binding domain 1 protein
C663_0632	COG0457	Tetratricopeptide repeat
C663_0633	COG1063	alcohol dehydrogenase
C663_0634	COG2211	Major facilitator Superfamily
C663_0635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C663_0636	COG1842	Phage shock protein A
C663_0637	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C663_0638	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C663_0639	COG4260	virion core protein, lumpy skin disease virus
C663_0641	COG2814	Major facilitator Superfamily
C663_0642	COG1063	alcohol dehydrogenase
C663_0643	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C663_0647	COG2267	carboxylic ester hydrolase activity
C663_0649	COG2132	Multicopper oxidase
C663_0650	COG1113	amino acid transport
C663_0651	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C663_0652	COG0714	Associated with various cellular activities
C663_0653	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C663_0654	COG1305	Transglutaminase-like
C663_0656	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C663_0656	COG0519	Catalyzes the synthesis of GMP from XMP
C663_0659	COG2252	PERMEase
C663_0660	COG3064	Membrane
C663_0662	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C663_0664	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C663_0665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C663_0666	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C663_0667	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C663_0668	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C663_0669	COG0047	phosphoribosylformylglycinamidine synthase activity
C663_0670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C663_0671	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C663_0672	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C663_0673	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C663_0674	COG0138	bifunctional purine biosynthesis protein purh
C663_0675	COG0151	Belongs to the GarS family
C663_0676	COG1522	sequence-specific DNA binding
C663_0677	COG0531	amino acid
C663_0679	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C663_0680	COG1470	cell adhesion involved in biofilm formation
C663_0682	COG0069	glutamate synthase activity
C663_0684	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C663_0685	COG0210	DNA helicase
C663_0686	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C663_0687	COG4851	CamS sex pheromone cAM373 precursor
C663_0688	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C663_0689	COG1285	pathogenesis
C663_0690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C663_0691	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C663_0692	COG0154	amidase activity
C663_0693	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C663_0694	COG1309	transcriptional regulator
C663_0695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C663_0696	COG1597	lipid kinase activity
C663_0697	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C663_0698	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C663_0700	COG5293	efflux transmembrane transporter activity
C663_0707	COG5444	nuclease activity
C663_0708	COG3586	endonuclease activity
C663_0710	COG0457	Tetratricopeptide repeat
C663_0711	COG0217	transcriptional regulatory protein
C663_0713	COG1309	transcriptional regulator
C663_0714	COG3631	Ketosteroid isomerase-related protein
C663_0715	COG0702	epimerase
C663_0718	COG3546	catalase activity
C663_0719	COG0454	-acetyltransferase
C663_0721	COG5578	integral membrane protein
C663_0722	COG2972	Histidine kinase
C663_0723	COG2207	Transcriptional regulator
C663_0723	COG4753	response regulator
C663_0724	COG1653	transport
C663_0725	COG1175	transmembrane transport
C663_0726	COG0395	ABC-type sugar transport system, permease component
C663_0727	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C663_0728	COG2207	Transcriptional regulator
C663_0729	COG2755	lipolytic protein G-D-S-L family
C663_0731	COG5578	integral membrane protein
C663_0732	COG3401	FG-GAP repeat protein
C663_0733	COG3401	FG-GAP repeat protein
C663_0734	COG2755	lipolytic protein G-D-S-L family
C663_0735	COG1874	Beta-galactosidase
C663_0738	COG1653	transport
C663_0739	COG4209	transmembrane transport
C663_0740	COG0395	ABC-type sugar transport system, permease component
C663_0741	COG1486	melibiose metabolic process
C663_0742	COG2323	membrane
C663_0743	COG2329	Antibiotic biosynthesis monooxygenase
C663_0744	COG0346	lactoylglutathione lyase activity
C663_0747	COG5583	Uncharacterized small protein (DUF2292)
C663_0748	COG0670	Belongs to the BI1 family
C663_0749	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C663_0751	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C663_0751	COG2124	cytochrome p450
C663_0752	COG1368	sulfuric ester hydrolase activity
C663_0753	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C663_0754	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C663_0755	COG1442	glycosyl transferase family 8
C663_0756	COG1216	Glycosyl transferase, family 2
C663_0757	COG1442	glycosyl transferase family 8
C663_0758	COG2223	nitrite transmembrane transporter activity
C663_0759	COG1011	Hydrolase
C663_0760	COG0531	amino acid
C663_0761	COG1012	belongs to the aldehyde dehydrogenase family
C663_0763	COG0488	(ABC) transporter
C663_0765	COG0789	Transcriptional regulator
C663_0766	COG2814	Major facilitator Superfamily
C663_0768	COG0488	(ABC) transporter
C663_0769	COG0513	Belongs to the DEAD box helicase family
C663_0770	COG0513	Belongs to the DEAD box helicase family
C663_0771	COG0456	acetyltransferase
C663_0772	COG2130	NADP-dependent
C663_0773	COG1120	ATPase activity
C663_0774	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C663_0775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C663_0776	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C663_0779	COG3866	Pectate lyase
C663_0780	COG0471	metal ion transport
C663_0781	COG3290	protein histidine kinase activity
C663_0782	COG4565	transcriptional regulatory protein
C663_0783	COG3181	Tripartite tricarboxylate transporter family receptor
C663_0785	COG2851	Citrate transporter
C663_0786	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C663_0787	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C663_0788	COG1254	Belongs to the acylphosphatase family
C663_0789	COG2258	MOSC domain
C663_0793	COG0024	Methionine aminopeptidase
C663_0794	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_0794	COG1263	PTS System
C663_0795	COG1368	sulfuric ester hydrolase activity
C663_0797	COG1115	amino acid carrier protein
C663_0798	COG0531	amino acid
C663_0801	COG0697	spore germination
C663_0802	COG1263	PTS System
C663_0802	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_0803	COG0366	Alpha amylase catalytic
C663_0804	COG2188	Transcriptional regulator
C663_0805	COG0778	Nitroreductase
C663_0806	COG0737	Belongs to the 5'-nucleotidase family
C663_0807	COG0693	protein deglycase activity
C663_0808	COG2814	Major facilitator Superfamily
C663_0809	COG4840	Belongs to the UPF0435 family
C663_0810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C663_0811	COG4980	gas vesicle protein
C663_0812	COG1295	ribonuclease BN
C663_0813	COG0477	Major facilitator Superfamily
C663_0815	COG0387	Pfam Sodium calcium exchanger
C663_0817	COG0668	transmembrane transport
C663_0821	COG0726	polysaccharide deacetylase
C663_0822	COG2084	Dehydrogenase
C663_0823	COG0598	Magnesium transport protein CorA
C663_0824	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C663_0825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C663_0826	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C663_0827	COG4637	Psort location Cytoplasmic, score
C663_0829	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C663_0830	COG0022	dehydrogenase e1 component
C663_0831	COG0508	dehydrogenase complex catalyzes the overall conversion of
C663_0832	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C663_0833	COG3284	Transcriptional regulator
C663_0835	COG1742	UPF0060 membrane protein
C663_0839	COG4842	Belongs to the WXG100 family
C663_0840	COG1486	melibiose metabolic process
C663_0841	COG1737	Transcriptional regulator
C663_0842	COG1263	PTS System
C663_0842	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_0843	COG1132	(ABC) transporter
C663_0844	COG1132	(ABC) transporter
C663_0845	COG2259	Doxx family
C663_0846	COG2514	catechol 2,3-dioxygenase activity
C663_0847	COG4585	Histidine kinase
C663_0848	COG2197	response regulator
C663_0849	COG1131	(ABC) transporter
C663_0850	COG0842	Transport permease protein
C663_0850	COG1511	domain protein
C663_0851	COG0842	Transport permease protein
C663_0853	COG1695	Transcriptional regulator
C663_0854	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C663_0858	COG1131	(ABC) transporter
C663_0859	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C663_0861	COG2814	Major facilitator Superfamily
C663_0862	COG2318	DinB family
C663_0863	COG2814	Major facilitator Superfamily
C663_0864	COG1846	Transcriptional regulator
C663_0865	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C663_0865	COG0392	lysyltransferase activity
C663_0866	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C663_0867	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C663_0868	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C663_0869	COG0384	phenazine biosynthesis protein PhzF
C663_0870	COG0778	Nitroreductase
C663_0873	COG1090	epimerase
C663_0874	COG2137	regulation of response to DNA damage stimulus
C663_0876	COG2814	Major facilitator Superfamily
C663_0879	COG3103	Sh3 type 3 domain protein
C663_0880	COG5658	integral membrane protein
C663_0881	COG0596	Alpha beta hydrolase
C663_0882	COG0463	Glycosyl transferase, family 2
C663_0883	COG4485	Bacterial membrane protein, YfhO
C663_0884	COG1988	membrane-bound metal-dependent
C663_0885	COG1194	a g-specific adenine glycosylase
C663_0887	COG1028	Short-chain dehydrogenase reductase Sdr
C663_0890	COG3557	Belongs to the UPF0374 family
C663_0891	COG1132	(ABC) transporter
C663_0892	COG4129	membrane
C663_0893	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C663_0894	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C663_0895	COG0735	belongs to the Fur family
C663_0898	COG4326	sporulation control protein
C663_0900	COG5577	PFAM Coat F domain
C663_0901	COG3340	Belongs to the peptidase S51 family
C663_0902	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C663_0903	COG0277	FAD linked oxidase domain protein
C663_0905	COG0753	catalase activity
C663_0906	COG1116	anion transmembrane transporter activity
C663_0907	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C663_0908	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C663_0909	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C663_0912	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C663_0914	COG1476	TRANSCRIPTIONal
C663_0915	COG3382	B3 4 domain protein
C663_0916	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C663_0918	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C663_0919	COG0789	Transcriptional regulator
C663_0920	COG1664	Polymer-forming cytoskeletal
C663_0921	COG1664	Polymer-forming cytoskeletal
C663_0922	COG2766	serine protein kinase
C663_0923	COG2718	Belongs to the UPF0229 family
C663_0924	COG1846	Transcriptional regulator
C663_0925	COG1566	PFAM secretion protein HlyD family protein
C663_0926	COG2814	Major facilitator Superfamily
C663_0927	COG0655	NAD(P)H dehydrogenase (quinone) activity
C663_0931	COG1725	Transcriptional regulator
C663_0932	COG1131	(ABC) transporter
C663_0933	COG1131	(ABC) transporter
C663_0934	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C663_0935	COG1278	Cold shock
C663_0936	COG1464	Belongs to the NlpA lipoprotein family
C663_0937	COG3706	GGDEF domain
C663_0938	COG1823	symporter activity
C663_0942	COG4085	toxin activity
C663_0942	COG1525	nuclease
C663_0942	COG0737	Belongs to the 5'-nucleotidase family
C663_0943	COG3764	Sortase (surface protein transpeptidase)
C663_0944	COG0564	pseudouridine synthase activity
C663_0946	COG0517	IMP dehydrogenase activity
C663_0947	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C663_0948	COG3153	acetyltransferase
C663_0948	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C663_0949	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C663_0950	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C663_0951	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C663_0952	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C663_0953	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C663_0954	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C663_0956	COG2203	Gaf domain
C663_0956	COG4585	Histidine kinase
C663_0957	COG2197	response regulator
C663_0960	COG0791	NLP P60 protein
C663_0960	COG1388	LysM domain
C663_0961	COG1959	2 iron, 2 sulfur cluster binding
C663_0964	COG1785	Belongs to the alkaline phosphatase family
C663_0965	COG1388	LysM domain
C663_0965	COG0791	NLP P60 protein
C663_0966	COG0583	DNA-binding transcription factor activity
C663_0967	COG0372	Belongs to the citrate synthase family
C663_0968	COG1028	Short-chain dehydrogenase reductase Sdr
C663_0969	COG0531	amino acid
C663_0970	COG0733	neurotransmitter:sodium symporter activity
C663_0971	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C663_0972	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C663_0973	COG0456	acetyltransferase
C663_0976	COG1595	DNA-templated transcription, initiation
C663_0977	COG0667	Aldo Keto reductase
C663_0978	COG0204	Acyl-transferase
C663_0979	COG1253	flavin adenine dinucleotide binding
C663_0980	COG0789	Transcriptional regulator
C663_0981	COG0436	Aminotransferase
C663_0982	COG1253	flavin adenine dinucleotide binding
C663_0983	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C663_0984	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C663_0985	COG0584	glycerophosphoryl diester phosphodiesterase
C663_0987	COG0668	transmembrane transport
C663_0988	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C663_0990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C663_0991	COG1757	Na H antiporter
C663_0992	COG0589	response to stress
C663_0994	COG1132	(ABC) transporter
C663_0995	COG1132	(ABC) transporter
C663_0996	COG0702	epimerase
C663_1000	COG0189	ligase activity
C663_1001	COG0189	ligase activity
C663_1002	COG4399	Belongs to the UPF0754 family
C663_1003	COG3679	Belongs to the UPF0342 family
C663_1004	COG4335	DNA alkylation repair
C663_1005	COG0561	phosphatase activity
C663_1006	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C663_1007	COG0475	glutathione-regulated potassium exporter activity
C663_1008	COG0490	domain, Protein
C663_1010	COG1024	Enoyl-CoA hydratase
C663_1012	COG4152	abc transporter atp-binding protein
C663_1013	COG1668	transmembrane transport
C663_1014	COG0420	3'-5' exonuclease activity
C663_1015	COG4717	serine-type aminopeptidase activity
C663_1016	COG3481	metal-dependent phosphohydrolase, HD sub domain
C663_1018	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C663_1022	COG1846	Transcriptional regulator
C663_1023	COG4980	gas vesicle protein
C663_1026	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C663_1027	COG0537	adenosine 5'-monophosphoramidase activity
C663_1028	COG1131	(ABC) transporter
C663_1029	COG4473	ABC transporter
C663_1031	COG1473	amidohydrolase
C663_1032	COG3069	C4-dicarboxylate transmembrane transporter activity
C663_1034	COG2329	Antibiotic biosynthesis monooxygenase
C663_1035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C663_1036	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C663_1039	COG1309	transcriptional regulator
C663_1040	COG1511	domain protein
C663_1041	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C663_1042	COG4377	Putative membrane peptidase family (DUF2324)
C663_1044	COG1363	Peptidase, m42
C663_1045	COG4405	Protein conserved in bacteria
C663_1046	COG1301	dicarboxylic acid transport
C663_1048	COG1234	tRNA 3'-trailer cleavage
C663_1049	COG0095	Lipoate-protein ligase
C663_1050	COG0702	epimerase
C663_1051	COG0318	PFAM AMP-dependent synthetase and ligase
C663_1053	COG0501	Belongs to the peptidase M48B family
C663_1054	COG1404	Belongs to the peptidase S8 family
C663_1055	COG0456	acetyltransferase
C663_1056	COG0604	alcohol dehydrogenase
C663_1058	COG0406	alpha-ribazole phosphatase activity
C663_1059	COG0183	Belongs to the thiolase family
C663_1060	COG0318	PFAM AMP-dependent synthetase and ligase
C663_1061	COG1268	BioY protein
C663_1062	COG0840	transmembrane signaling receptor activity
C663_1063	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C663_1063	COG0723	plastoquinol--plastocyanin reductase activity
C663_1064	COG1028	Short-chain dehydrogenase reductase Sdr
C663_1066	COG4903	ComK protein
C663_1067	COG1028	Short-chain dehydrogenase reductase Sdr
C663_1069	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C663_1072	COG0398	Pfam SNARE associated Golgi protein
C663_1073	COG0681	Belongs to the peptidase S26 family
C663_1074	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C663_1075	COG1846	Transcriptional regulator
C663_1076	COG0738	Major facilitator superfamily
C663_1077	COG0673	inositol 2-dehydrogenase activity
C663_1078	COG0561	phosphatase activity
C663_1079	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C663_1080	COG1609	Transcriptional regulator
C663_1081	COG3180	Ammonia monooxygenase
C663_1082	COG2814	Major facilitator Superfamily
C663_1082	COG0477	Major facilitator Superfamily
C663_1083	COG4533	DNA binding
C663_1085	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C663_1086	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C663_1087	COG1074	ATP-dependent DNA helicase activity
C663_1088	COG0420	3'-5' exonuclease activity
C663_1089	COG0419	ATPase involved in DNA repair
C663_1090	COG1403	HNH endonuclease
C663_1098	COG5337	Spore coat protein CotH
C663_1099	COG0179	Fumarylacetoacetate (FAA) hydrolase
C663_1101	COG1404	Belongs to the peptidase S8 family
C663_1103	COG0367	asparagine synthase
C663_1104	COG1562	ergosterol biosynthetic process
C663_1105	COG0534	Mate efflux family protein
C663_1106	COG1917	Cupin 2, conserved barrel domain protein
C663_1106	COG2207	Transcriptional regulator
C663_1107	COG1609	Transcriptional regulator
C663_1108	COG0673	inositol 2-dehydrogenase activity
C663_1109	COG2318	DinB family
C663_1110	COG1279	arginine transmembrane transporter activity
C663_1111	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C663_1112	COG1357	PFAM Pentapeptide repeats (8 copies)
C663_1113	COG2267	carboxylic ester hydrolase activity
C663_1114	COG0529	Catalyzes the synthesis of activated sulfate
C663_1115	COG2046	Belongs to the sulfate adenylyltransferase family
C663_1116	COG0175	sulfate reduction
C663_1117	COG2045	Belongs to the ComB family
C663_1118	COG1809	phosphosulfolactate synthase activity
C663_1119	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C663_1120	COG4948	Mandelate Racemase Muconate Lactonizing
C663_1121	COG2814	Major facilitator Superfamily
C663_1122	COG0454	-acetyltransferase
C663_1124	COG2153	protein acetylation
C663_1125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C663_1125	COG0646	methionine synthase
C663_1127	COG1666	GTP binding
C663_1128	COG2996	Protein conserved in bacteria
C663_1132	COG1695	Transcriptional regulator
C663_1135	COG3227	Zinc metalloprotease (Elastase)
C663_1136	COG1307	EDD domain protein, DegV family
C663_1137	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C663_1140	COG0561	phosphatase activity
C663_1141	COG1073	alpha beta
C663_1142	COG2151	metal-sulfur cluster biosynthetic enzyme
C663_1144	COG0277	FAD linked oxidase domain protein
C663_1145	COG2271	Major facilitator Superfamily
C663_1146	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C663_1149	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C663_1150	COG0505	Belongs to the CarA family
C663_1151	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C663_1152	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C663_1155	COG2267	carboxylic ester hydrolase activity
C663_1157	COG1744	ABC transporter substrate-binding protein PnrA-like
C663_1161	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C663_1162	COG5504	Zn-dependent protease
C663_1163	COG0444	Belongs to the ABC transporter superfamily
C663_1164	COG4608	Belongs to the ABC transporter superfamily
C663_1166	COG0601	transmembrane transport
C663_1167	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C663_1169	COG0180	Tryptophanyl-tRNA synthetase
C663_1170	COG4166	transmembrane transport
C663_1171	COG0601	transmembrane transport
C663_1172	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C663_1173	COG0444	Belongs to the ABC transporter superfamily
C663_1174	COG4608	Belongs to the ABC transporter superfamily
C663_1175	COG2814	Major facilitator Superfamily
C663_1176	COG0456	acetyltransferase
C663_1177	COG1393	Belongs to the ArsC family
C663_1178	COG0861	Integral membrane protein TerC family
C663_1179	COG4862	establishment of competence for transformation
C663_1180	COG4469	Competence protein
C663_1181	COG1164	Oligoendopeptidase f
C663_1184	COG2346	COG2346, Truncated hemoglobins
C663_1185	COG0741	lytic transglycosylase activity
C663_1186	COG4116	CYTH
C663_1189	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C663_1190	COG0564	pseudouridine synthase activity
C663_1191	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C663_1192	COG0569	domain protein
C663_1192	COG0475	glutathione-regulated potassium exporter activity
C663_1193	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C663_1194	COG0352	thiamine-phosphate diphosphorylase activity
C663_1195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C663_1196	COG2104	thiamine diphosphate biosynthetic process
C663_1197	COG2022	thiamine diphosphate biosynthetic process
C663_1198	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C663_1199	COG0351	phosphomethylpyrimidine kinase
C663_1200	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C663_1211	COG0210	DNA helicase
C663_1213	COG2153	protein acetylation
C663_1214	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C663_1215	COG2382	esterase
C663_1216	COG0626	cystathionine gamma-synthase activity
C663_1219	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C663_1220	COG5505	Protein of unknown function (DUF819)
C663_1229	COG0457	Tetratricopeptide repeat
C663_1230	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C663_1231	COG3711	transcriptional antiterminator
C663_1231	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C663_1232	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C663_1232	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C663_1232	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C663_1233	COG1482	cell wall glycoprotein biosynthetic process
C663_1235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C663_1239	COG0109	protoheme IX farnesyltransferase activity
C663_1245	COG5504	Zn-dependent protease
C663_1246	COG2205	protein histidine kinase activity
C663_1248	COG3383	formate dehydrogenase (NAD+) activity
C663_1249	COG2427	Protein of unknown function (DUF1641)
C663_1251	COG1051	belongs to the nudix hydrolase family
C663_1252	COG2124	cytochrome p450
C663_1253	COG1819	glycosyl
C663_1255	COG1587	Uroporphyrinogen-III synthase
C663_1256	COG0390	transport system, permease component
C663_1257	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C663_1258	COG0697	spore germination
C663_1259	COG4297	protein containing double-stranded beta helix domain
C663_1261	COG1252	NADH dehydrogenase
C663_1262	COG1904	glucuronate isomerase
C663_1263	COG2211	Major facilitator Superfamily
C663_1264	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C663_1265	COG1063	alcohol dehydrogenase
C663_1266	COG1312	Catalyzes the dehydration of D-mannonate
C663_1267	COG1028	Short-chain dehydrogenase reductase Sdr
C663_1268	COG2271	Major facilitator Superfamily
C663_1269	COG1609	Transcriptional regulator
C663_1270	COG0246	Mannitol dehydrogenase
C663_1271	COG2721	sulfolactate sulfo-lyase activity
C663_1272	COG0730	response to heat
C663_1273	COG2318	DinB family
C663_1274	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C663_1275	COG0457	Tetratricopeptide repeat
C663_1277	COG2350	Protein conserved in bacteria
C663_1280	COG4195	phage-related replication protein
C663_1281	COG3546	catalase activity
C663_1285	COG1522	sequence-specific DNA binding
C663_1286	COG1484	DNA-dependent DNA replication
C663_1290	COG1595	DNA-templated transcription, initiation
C663_1291	COG5484	DNA packaging
C663_1291	COG3728	DNA packaging
C663_1293	COG5518	Phage portal protein
C663_1294	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C663_1295	COG4653	Phage capsid family
C663_1304	COG3953	SLT domain
C663_1304	COG5412	phage tail tape measure protein
C663_1305	COG1652	LysM domain
C663_1306	COG4193	domain, Protein
C663_1308	COG3628	GPW Gp25 family protein
C663_1309	COG3299	homolog of phage Mu protein gp47
C663_1310	COG3778	Protein conserved in bacteria
C663_1318	COG5632	N-Acetylmuramoyl-L-alanine amidase
C663_1318	COG3409	Peptidoglycan-binding domain 1 protein
C663_1322	COG0306	phosphate transporter
C663_1323	COG1392	Phosphate transport regulator
C663_1324	COG0531	amino acid
C663_1325	COG0346	lactoylglutathione lyase activity
C663_1326	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C663_1328	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C663_1329	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C663_1330	COG2362	D-Aminopeptidase
C663_1331	COG0601	transmembrane transport
C663_1332	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C663_1333	COG0444	Belongs to the ABC transporter superfamily
C663_1335	COG1619	proteins homologs of microcin C7 resistance protein MccF
C663_1336	COG4948	Mandelate Racemase Muconate Lactonizing
C663_1337	COG0791	NLP P60 protein
C663_1338	COG4608	Belongs to the ABC transporter superfamily
C663_1339	COG2706	6-phosphogluconolactonase activity
C663_1340	COG1834	amidinotransferase
C663_1341	COG1607	acyl-coa hydrolase
C663_1342	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C663_1342	COG1017	nitric oxide dioxygenase activity
C663_1344	COG2323	membrane
C663_1345	COG2318	DinB family
C663_1346	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C663_1347	COG2076	Multidrug Resistance protein
C663_1348	COG2076	Multidrug Resistance protein
C663_1349	COG0788	formyltetrahydrofolate deformylase activity
C663_1350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C663_1351	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C663_1352	COG1764	response to oxidative stress
C663_1353	COG1846	Transcriptional regulator
C663_1354	COG1764	response to oxidative stress
C663_1355	COG0590	tRNA wobble adenosine to inosine editing
C663_1357	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C663_1358	COG1404	Belongs to the peptidase S8 family
C663_1359	COG1366	Belongs to the anti-sigma-factor antagonist family
C663_1360	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C663_1361	COG1122	ATPase activity
C663_1362	COG4721	ABC-type cobalt transport system, permease component
C663_1364	COG0745	RESPONSE REGULATOR receiver
C663_1365	COG5002	protein histidine kinase activity
C663_1365	COG3850	Histidine kinase
C663_1366	COG3212	peptidase
C663_1367	COG3212	peptidase
C663_1369	COG2239	Acts as a magnesium transporter
C663_1370	COG0789	Transcriptional regulator
C663_1373	COG1846	Transcriptional regulator
C663_1374	COG0726	polysaccharide deacetylase
C663_1375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C663_1376	COG1408	metallophosphoesterase
C663_1378	COG0463	Glycosyl transferase, family 2
C663_1379	COG3285	dna ligase
C663_1379	COG1793	dna ligase
C663_1380	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C663_1381	COG5001	Diguanylate cyclase
C663_1381	COG3300	MHYT domain
C663_1382	COG0586	Pfam SNARE associated Golgi protein
C663_1383	COG0861	Integral membrane protein TerC family
C663_1384	COG1191	sigma factor activity
C663_1388	COG0501	Belongs to the peptidase M48B family
C663_1389	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C663_1392	COG3594	Acyltransferase
C663_1393	COG5002	protein histidine kinase activity
C663_1394	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C663_1396	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C663_1397	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C663_1398	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C663_1399	COG0436	Aminotransferase
C663_1400	COG1850	ribulose-bisphosphate carboxylase activity
C663_1401	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C663_1403	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C663_1404	COG3339	Conserved Protein
C663_1407	COG3852	Histidine kinase
C663_1408	COG1846	Transcriptional regulator
C663_1409	COG1360	Flagellar Motor Protein
C663_1411	COG0542	response to heat
C663_1412	COG3949	Membrane
C663_1413	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C663_1414	COG0720	synthase
C663_1415	COG0602	queuosine metabolic process
C663_1416	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C663_1417	COG4641	Protein conserved in bacteria
C663_1417	COG1388	LysM domain
C663_1419	COG3858	chitin binding
C663_1421	COG4873	Protein conserved in bacteria
C663_1423	COG3773	Cell wall hydrolase
C663_1424	COG2244	polysaccharide biosynthetic process
C663_1425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C663_1426	COG2217	Heavy metal translocating P-type atpase
C663_1428	COG0006	proline dipeptidase activity
C663_1430	COG1609	Transcriptional regulator
C663_1431	COG3711	transcriptional antiterminator
C663_1432	COG1263	PTS System
C663_1432	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_1432	COG2190	(PTS) system
C663_1433	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C663_1434	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C663_1436	COG1533	DNA photolyase activity
C663_1437	COG0456	acetyltransferase
C663_1438	COG0840	transmembrane signaling receptor activity
C663_1439	COG2084	Dehydrogenase
C663_1440	COG2340	Cysteine-rich secretory protein family
C663_1441	COG0768	penicillin binding
C663_1442	COG4191	Histidine kinase
C663_1443	COG0436	Aminotransferase
C663_1445	COG0835	chemotaxis
C663_1445	COG0784	Response regulator, receiver
C663_1447	COG2814	Major facilitator Superfamily
C663_1448	COG1376	ErfK ybiS ycfS ynhG family protein
C663_1449	COG1408	metallophosphoesterase
C663_1450	COG1028	Short-chain dehydrogenase reductase Sdr
C663_1451	COG2200	EAL domain
C663_1452	COG4703	Protein of unknown function (DUF1797)
C663_1453	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C663_1455	COG0517	IMP dehydrogenase activity
C663_1456	COG0583	DNA-binding transcription factor activity
C663_1457	COG0716	FMN binding
C663_1459	COG0716	FMN binding
C663_1460	COG2171	N-acyltransferase activity
C663_1461	COG1473	amidohydrolase
C663_1463	COG0668	transmembrane transport
C663_1464	COG0450	alkyl hydroperoxide reductase
C663_1465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C663_1468	COG0746	molybdenum cofactor guanylyltransferase activity
C663_1469	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C663_1470	COG0303	'Molybdopterin
C663_1472	COG0314	molybdopterin synthase activity
C663_1473	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C663_1474	COG1132	(ABC) transporter
C663_1475	COG1132	(ABC) transporter
C663_1477	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C663_1478	COG1136	(ABC) transporter
C663_1479	COG0577	efflux transmembrane transporter activity
C663_1480	COG1349	DNA-binding transcription factor activity
C663_1481	COG1105	Belongs to the carbohydrate kinase PfkB family
C663_1482	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C663_1482	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C663_1482	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C663_1483	COG0681	Belongs to the peptidase S26 family
C663_1485	COG0488	(ABC) transporter
C663_1486	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C663_1487	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C663_1488	COG2309	aminopeptidase activity
C663_1490	COG1077	Cell shape determining protein MreB Mrl
C663_1491	COG2002	toxin-antitoxin pair type II binding
C663_1492	COG3852	Histidine kinase
C663_1493	COG2105	PFAM AIG2 family protein
C663_1493	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C663_1494	COG0569	domain protein
C663_1495	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C663_1496	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C663_1500	COG0497	DNA recombination
C663_1501	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C663_1502	COG0022	dehydrogenase e1 component
C663_1503	COG0508	dehydrogenase complex catalyzes the overall conversion of
C663_1504	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C663_1505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C663_1507	COG1982	Orn Lys Arg decarboxylase major
C663_1508	COG4476	Belongs to the UPF0223 family
C663_1509	COG4493	Belongs to the UPF0637 family
C663_1511	COG0483	inositol monophosphate 1-phosphatase activity
C663_1513	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C663_1517	COG1595	DNA-templated transcription, initiation
C663_1525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C663_1526	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C663_1527	COG2066	Belongs to the glutaminase family
C663_1528	COG4838	Belongs to the UPF0358 family
C663_1529	COG0772	Belongs to the SEDS family
C663_1530	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C663_1532	COG0109	protoheme IX farnesyltransferase activity
C663_1533	COG2010	Cytochrome c
C663_1533	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C663_1534	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C663_1535	COG1845	cytochrome c oxidase, subunit III
C663_1536	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C663_1537	COG3336	cytochrome c oxidase
C663_1539	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C663_1540	COG2340	Cysteine-rich secretory protein family
C663_1543	COG3679	Belongs to the UPF0342 family
C663_1544	COG4471	UPF0298 protein
C663_1545	COG0742	ribosomal rna small subunit methyltransferase
C663_1546	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C663_1547	COG3314	Sporulation integral membrane protein YlbJ
C663_1548	COG1752	Esterase of the alpha-beta hydrolase superfamily
C663_1549	COG3480	Lon protease (S16) C-terminal proteolytic domain
C663_1551	COG1399	metal-binding, possibly nucleic acid-binding protein
C663_1553	COG0454	-acetyltransferase
C663_1554	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C663_1555	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C663_1556	COG2001	Belongs to the MraZ family
C663_1557	COG0275	rRNA processing
C663_1559	COG4839	cell division protein FtsL
C663_1561	COG0768	penicillin binding
C663_1562	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C663_1563	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C663_1564	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C663_1565	COG0772	Belongs to the SEDS family
C663_1566	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C663_1567	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C663_1568	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C663_1569	COG3879	Bacterial protein of unknown function (DUF881)
C663_1570	COG3879	Bacterial protein of unknown function (DUF881)
C663_1571	COG3856	small basic protein
C663_1573	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C663_1574	COG1404	Belongs to the peptidase S8 family
C663_1574	COG4412	M6 family metalloprotease domain protein
C663_1576	COG1191	sigma factor activity
C663_1577	COG1191	sigma factor activity
C663_1578	COG1119	ATPase activity
C663_1579	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C663_1580	COG1873	PFAM PRC-barrel domain
C663_1582	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C663_1583	COG1799	cell septum assembly
C663_1584	COG0762	integral membrane protein
C663_1585	COG2302	S4 RNA-binding domain
C663_1586	COG3599	regulation of cell shape
C663_1587	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C663_1588	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C663_1589	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C663_1590	COG0564	pseudouridine synthase activity
C663_1591	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C663_1592	COG2233	PERMEase
C663_1593	COG0540	Belongs to the ATCase OTCase family
C663_1594	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C663_1595	COG0505	Belongs to the CarA family
C663_1596	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C663_1597	COG0543	2 iron, 2 sulfur cluster binding
C663_1599	COG0284	orotidine-5'-phosphate decarboxylase activity
C663_1600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C663_1601	COG0175	sulfate reduction
C663_1602	COG0306	phosphate transporter
C663_1603	COG2046	Belongs to the sulfate adenylyltransferase family
C663_1604	COG0529	Catalyzes the synthesis of activated sulfate
C663_1605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C663_1606	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C663_1607	COG1648	precorrin-2 dehydrogenase activity
C663_1609	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C663_1610	COG1561	YicC-like family, N-terminal region
C663_1611	COG2052	Domain of unknown function (DUF370)
C663_1612	COG0194	GDP metabolic process
C663_1613	COG1758	RNA polymerase activity
C663_1614	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C663_1615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C663_1616	COG0242	peptide deformylase activity
C663_1617	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C663_1618	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C663_1618	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C663_1619	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C663_1620	COG0631	protein serine/threonine phosphatase activity
C663_1621	COG0515	serine threonine protein kinase
C663_1621	COG2815	serine threonine protein kinase
C663_1622	COG1162	GTPase activity
C663_1623	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C663_1624	COG1564	THIamine pyrophosphokinase
C663_1626	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C663_1627	COG1302	Protein conserved in bacteria
C663_1628	COG1461	Dihydroxyacetone kinase
C663_1629	COG1760	l-serine dehydratase
C663_1630	COG1760	l-serine dehydratase
C663_1631	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C663_1632	COG1349	DNA-binding transcription factor activity
C663_1632	COG2050	protein possibly involved in aromatic compounds catabolism
C663_1633	COG0416	fatty acid biosynthetic process
C663_1634	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C663_1635	COG1028	Short-chain dehydrogenase reductase Sdr
C663_1636	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C663_1637	COG0571	ribonuclease III activity
C663_1638	COG1196	nuclear chromosome segregation
C663_1639	COG0552	protein localization to endoplasmic reticulum
C663_1641	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C663_1642	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C663_1643	COG0228	four-way junction DNA binding
C663_1644	COG1837	Belongs to the UPF0109 family
C663_1646	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C663_1647	COG0336	Belongs to the RNA methyltransferase TrmD family
C663_1648	COG0335	large ribosomal subunit rRNA binding
C663_1649	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C663_1650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C663_1652	COG2257	FlhB HrpN YscU SpaS Family
C663_1653	COG0045	succinate-CoA ligase (ADP-forming) activity
C663_1654	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C663_1655	COG0758	DNA mediated transformation
C663_1656	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C663_1658	COG4974	Belongs to the 'phage' integrase family
C663_1659	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C663_1660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C663_1661	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C663_1662	COG1815	bacterial-type flagellum-dependent cell motility
C663_1663	COG1558	bacterial-type flagellum-dependent cell motility
C663_1664	COG1677	Flagellar hook-basal body complex protein FliE
C663_1665	COG1766	The M ring may be actively involved in energy transduction
C663_1666	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C663_1667	COG1317	bacterial-type flagellum organization
C663_1668	COG1157	protein secretion by the type III secretion system
C663_1669	COG2882	bacterial-type flagellum organization
C663_1672	COG3144	bacterial-type flagellum assembly
C663_1673	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C663_1674	COG4786	Flagellar basal body rod
C663_1675	COG1582	Flagellar protein (FlbD)
C663_1676	COG1580	Controls the rotational direction of flagella during chemotaxis
C663_1677	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C663_1678	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C663_1678	COG1776	CheC inhibitor of MCP methylation
C663_1679	COG2201	protein-glutamate methylesterase activity
C663_1680	COG3190	flagellar
C663_1681	COG1338	Plays a role in the flagellum-specific transport system
C663_1682	COG1987	bacterial-type flagellum assembly
C663_1683	COG1684	flagellar biosynthetic protein fliR
C663_1685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C663_1686	COG1419	protein localization to endoplasmic reticulum
C663_1687	COG0455	bacterial-type flagellum organization
C663_1688	COG2201	protein-glutamate methylesterase activity
C663_1689	COG2198	Histidine kinase
C663_1689	COG0643	Histidine kinase
C663_1690	COG0835	chemotaxis
C663_1691	COG1776	CheC inhibitor of MCP methylation
C663_1692	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C663_1693	COG1191	sigma factor activity
C663_1695	COG0052	Belongs to the universal ribosomal protein uS2 family
C663_1696	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C663_1697	COG0528	UMP kinase activity
C663_1698	COG0233	cytoplasmic translational termination
C663_1699	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C663_1700	COG4589	Belongs to the CDS family
C663_1701	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C663_1702	COG0750	zinc metalloprotease
C663_1703	COG0442	prolyl-tRNA aminoacylation
C663_1704	COG2176	DNA-directed DNA polymerase activity
C663_1705	COG0779	Required for maturation of 30S ribosomal subunits
C663_1706	COG0195	Participates in both transcription termination and antitermination
C663_1707	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C663_1708	COG1358	cellular component organization or biogenesis
C663_1709	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C663_1710	COG1550	Protein conserved in bacteria
C663_1711	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C663_1712	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C663_1713	COG0196	riboflavin kinase activity
C663_1714	COG1185	polyribonucleotide nucleotidyltransferase activity
C663_1715	COG0726	polysaccharide deacetylase
C663_1716	COG0612	Peptidase, M16
C663_1717	COG1873	PFAM PRC-barrel domain
C663_1718	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C663_1719	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C663_1720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C663_1721	COG0527	aspartate kinase activity
C663_1722	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C663_1723	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C663_1724	COG0740	serine-type endopeptidase activity
C663_1727	COG2188	Transcriptional regulator
C663_1728	COG2814	Major facilitator Superfamily
C663_1729	COG0612	Peptidase, M16
C663_1730	COG0612	Peptidase, M16
C663_1731	COG0300	oxidoreductase activity
C663_1734	COG1426	Protein conserved in bacteria
C663_1735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C663_1736	COG1546	Belongs to the CinA family
C663_1736	COG1058	Belongs to the CinA family
C663_1738	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C663_1739	COG1418	mRNA catabolic process
C663_1740	COG1692	metallophosphoesterase
C663_1741	COG2359	stage V sporulation protein S
C663_1742	COG1063	alcohol dehydrogenase
C663_1743	COG0156	8-amino-7-oxononanoate synthase activity
C663_1744	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C663_1745	COG4550	Control of competence regulator ComK, YlbF/YmcA
C663_1747	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C663_1748	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C663_1751	COG3226	Transcriptional regulator
C663_1752	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C663_1753	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C663_1754	COG3321	synthase
C663_1755	COG2070	2-Nitropropane dioxygenase
C663_1755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C663_1756	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C663_1757	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C663_1758	COG3425	synthase
C663_1759	COG1024	Enoyl-CoA hydratase
C663_1760	COG1024	Enoyl-CoA hydratase
C663_1762	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_1762	COG0300	oxidoreductase activity
C663_1762	COG1028	Short-chain dehydrogenase reductase Sdr
C663_1762	COG3321	synthase
C663_1762	COG0318	PFAM AMP-dependent synthetase and ligase
C663_1765	COG0318	PFAM AMP-dependent synthetase and ligase
C663_1765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_1765	COG0300	oxidoreductase activity
C663_1765	COG1028	Short-chain dehydrogenase reductase Sdr
C663_1765	COG3321	synthase
C663_1767	COG4221	oxidoreductase activity
C663_1767	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C663_1767	COG0300	oxidoreductase activity
C663_1767	COG3321	synthase
C663_1769	COG1028	Short-chain dehydrogenase reductase Sdr
C663_1769	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_1769	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C663_1769	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C663_1769	COG3321	synthase
C663_1770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_1770	COG3321	synthase
C663_1770	COG4221	oxidoreductase activity
C663_1770	COG1028	Short-chain dehydrogenase reductase Sdr
C663_1771	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C663_1771	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C663_1771	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C663_1771	COG3321	synthase
C663_1772	COG2124	cytochrome p450
C663_1774	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C663_1775	COG1404	Belongs to the peptidase S8 family
C663_1777	COG4195	phage-related replication protein
C663_1778	COG1764	response to oxidative stress
C663_1779	COG2076	Multidrug Resistance protein
C663_1780	COG2076	Multidrug Resistance protein
C663_1782	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C663_1783	COG1923	regulation of RNA biosynthetic process
C663_1786	COG1780	Probably involved in ribonucleotide reductase function
C663_1787	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C663_1788	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C663_1789	COG4112	unkown
C663_1790	COG0860	N-Acetylmuramoyl-L-alanine amidase
C663_1791	COG0464	growth
C663_1792	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C663_1793	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C663_1794	COG0789	Transcriptional regulator
C663_1795	COG0174	glutamine synthetase
C663_1800	COG5444	nuclease activity
C663_1804	COG4282	regulation of fungal-type cell wall biogenesis
C663_1806	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C663_1808	COG3655	Transcriptional regulator
C663_1812	COG2211	Major facilitator Superfamily
C663_1813	COG3507	Belongs to the glycosyl hydrolase 43 family
C663_1814	COG1940	carbohydrate kinase activity
C663_1815	COG2115	Belongs to the xylose isomerase family
C663_1816	COG1070	Carbohydrate kinase
C663_1818	COG1525	nuclease
C663_1819	COG2814	Major facilitator Superfamily
C663_1820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C663_1822	COG0756	dUTP diphosphatase activity
C663_1823	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C663_1825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C663_1826	COG3832	glyoxalase III activity
C663_1828	COG0697	spore germination
C663_1829	COG0531	amino acid
C663_1835	COG4195	phage-related replication protein
C663_1837	COG0346	lactoylglutathione lyase activity
C663_1838	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C663_1839	COG1388	LysM domain
C663_1840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C663_1841	COG4224	UPF0291 protein
C663_1842	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C663_1844	COG3763	UPF0154 protein
C663_1846	COG0785	Cytochrome C biogenesis protein
C663_1847	COG2201	protein-glutamate methylesterase activity
C663_1848	COG4846	Membrane protein involved in cytochrome C biogenesis
C663_1850	COG0071	Belongs to the small heat shock protein (HSP20) family
C663_1853	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C663_1854	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C663_1858	COG0824	Thioesterase
C663_1860	COG4841	protein insertion into membrane
C663_1861	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C663_1862	COG1832	CoA-binding protein
C663_1863	COG0187	DNA topoisomerase II activity
C663_1864	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C663_1867	COG1115	amino acid carrier protein
C663_1868	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C663_1871	COG5520	Belongs to the glycosyl hydrolase 30 family
C663_1872	COG3507	Belongs to the glycosyl hydrolase 43 family
C663_1873	COG2246	polysaccharide biosynthetic process
C663_1874	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C663_1875	COG0586	Pfam SNARE associated Golgi protein
C663_1876	COG2404	hydrolase activity, acting on ester bonds
C663_1877	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C663_1878	COG1024	Enoyl-CoA hydratase
C663_1879	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C663_1880	COG0511	ligase activity, forming carbon-carbon bonds
C663_1881	COG0439	Biotin carboxylase
C663_1882	COG0318	PFAM AMP-dependent synthetase and ligase
C663_1883	COG1960	acyl-CoA dehydrogenase activity
C663_1885	COG1649	PFAM Uncharacterised BCR, COG1649
C663_1887	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_1887	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C663_1890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_1893	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_1894	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_1897	COG2027	D-alanyl-D-alanine carboxypeptidase
C663_1898	COG2017	converts alpha-aldose to the beta-anomer
C663_1899	COG0534	Mate efflux family protein
C663_1901	COG0582	viral genome integration into host DNA
C663_1902	COG0166	Belongs to the GPI family
C663_1903	COG0405	Gamma-glutamyltransferase
C663_1904	COG0583	DNA-binding transcription factor activity
C663_1905	COG0604	alcohol dehydrogenase
C663_1906	COG0493	'glutamate synthase
C663_1907	COG0067	glutamate synthase
C663_1907	COG0069	glutamate synthase activity
C663_1907	COG0070	glutamate synthase
C663_1908	COG0070	glutamate synthase
C663_1908	COG0069	glutamate synthase activity
C663_1908	COG0067	glutamate synthase
C663_1909	COG0583	DNA-binding transcription factor activity
C663_1910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C663_1911	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C663_1913	COG0300	oxidoreductase activity
C663_1914	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C663_1916	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C663_1917	COG2814	Major facilitator Superfamily
C663_1918	COG1070	Carbohydrate kinase
C663_1919	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C663_1920	COG0243	molybdopterin cofactor binding
C663_1925	COG0840	transmembrane signaling receptor activity
C663_1925	COG5278	phosphoserine phosphatase activity
C663_1926	COG2368	4-hydroxyphenylacetate
C663_1927	COG4305	rare lipoprotein A
C663_1928	COG3619	membrane
C663_1929	COG3866	Pectate lyase
C663_1930	COG2135	peptidase activity
C663_1932	COG2140	Oxalate decarboxylase
C663_1935	COG2720	vancomycin resistance protein
C663_1937	COG3655	Transcriptional regulator
C663_1938	COG3739	integral membrane protein
C663_1939	COG0583	DNA-binding transcription factor activity
C663_1940	COG0697	spore germination
C663_1942	COG0693	protein deglycase activity
C663_1943	COG2367	Beta-lactamase
C663_1945	COG0574	Belongs to the PEP-utilizing enzyme family
C663_1945	COG3848	Pyruvate phosphate dikinase
C663_1947	COG1793	dna ligase
C663_1951	COG5444	nuclease activity
C663_1952	COG4282	regulation of fungal-type cell wall biogenesis
C663_1953	COG1231	oxidoreductase activity
C663_1954	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C663_1955	COG2207	Transcriptional regulator
C663_1955	COG0662	Cupin 2, conserved barrel domain protein
C663_1956	COG0456	acetyltransferase
C663_1957	COG1309	transcriptional regulator
C663_1958	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C663_1959	COG3708	Transcriptional regulator
C663_1960	COG2378	regulation of single-species biofilm formation
C663_1962	COG0640	Transcriptional regulator
C663_1963	COG0741	lytic transglycosylase activity
C663_1964	COG2322	membrane
C663_1967	COG1619	proteins homologs of microcin C7 resistance protein MccF
C663_1968	COG3239	Fatty acid desaturase
C663_1969	COG4585	Histidine kinase
C663_1970	COG2197	response regulator
C663_1971	COG1388	LysM domain
C663_1971	COG3584	3D domain protein
C663_1972	COG0514	ATP-dependent DNA helicase (RecQ)
C663_1974	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C663_1975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C663_1978	COG0071	Belongs to the small heat shock protein (HSP20) family
C663_1983	COG1012	belongs to the aldehyde dehydrogenase family
C663_1984	COG1657	PFAM Prenyltransferase squalene oxidase
C663_1985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C663_1986	COG0733	neurotransmitter:sodium symporter activity
C663_1987	COG0385	Bile acid
C663_1988	COG0508	dehydrogenase complex catalyzes the overall conversion of
C663_1989	COG0567	Dehydrogenase, E1 component
C663_1990	COG4548	von Willebrand factor, type A
C663_1992	COG0714	Associated with various cellular activities
C663_1993	COG2032	superoxide dismutase activity
C663_1994	COG1388	LysM domain
C663_1994	COG0791	NLP P60 protein
C663_1996	COG1819	glycosyl
C663_1998	COG0534	Mate efflux family protein
C663_1999	COG1366	Belongs to the anti-sigma-factor antagonist family
C663_2000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C663_2001	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C663_2003	COG2962	Rard protein
C663_2006	COG2610	gluconate transmembrane transporter activity
C663_2007	COG1942	4-Oxalocrotonate Tautomerase
C663_2008	COG1733	regulation of RNA biosynthetic process
C663_2009	COG0778	Nitroreductase
C663_2010	COG0400	carboxylic ester hydrolase activity
C663_2011	COG0346	lactoylglutathione lyase activity
C663_2013	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C663_2014	COG3409	Peptidoglycan-binding domain 1 protein
C663_2014	COG0793	Belongs to the peptidase S41A family
C663_2015	COG2226	methyltransferase
C663_2017	COG1876	peptidase activity
C663_2018	COG0813	purine-nucleoside phosphorylase activity
C663_2021	COG0671	phosphoesterase, PA-phosphatase related
C663_2025	COG4479	Belongs to the UPF0346 family
C663_2027	COG1509	lysine 2,3-aminomutase activity
C663_2028	COG0456	acetyltransferase
C663_2029	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C663_2030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C663_2031	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C663_2032	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C663_2034	COG0456	acetyltransferase
C663_2035	COG0463	Glycosyl transferase, family 2
C663_2038	COG4641	Protein conserved in bacteria
C663_2039	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C663_2040	COG1086	Polysaccharide biosynthesis protein
C663_2041	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C663_2042	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C663_2043	COG1846	Transcriptional regulator
C663_2044	COG0534	Mate efflux family protein
C663_2046	COG4698	Protein conserved in bacteria
C663_2047	COG2755	lipolytic protein G-D-S-L family
C663_2048	COG1999	signal sequence binding
C663_2050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C663_2051	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C663_2053	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C663_2054	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C663_2055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C663_2057	COG2521	methyltransferase
C663_2057	COG2136	Putative SAM-dependent methyltransferase
C663_2059	COG0129	dihydroxy-acid dehydratase activity
C663_2060	COG1413	lyase activity
C663_2061	COG1418	mRNA catabolic process
C663_2062	COG0386	Belongs to the glutathione peroxidase family
C663_2063	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C663_2064	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C663_2065	COG1278	Cold shock
C663_2069	COG0328	RNA-DNA hybrid ribonuclease activity
C663_2070	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C663_2071	COG0328	RNA-DNA hybrid ribonuclease activity
C663_2073	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C663_2076	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C663_2077	COG1755	Isoprenylcysteine carboxyl methyltransferase
C663_2078	COG3424	synthase
C663_2079	COG2233	PERMEase
C663_2080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C663_2081	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C663_2083	COG0800	Aldolase
C663_2084	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C663_2085	COG1609	Transcriptional regulator
C663_2086	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C663_2087	COG1028	Short-chain dehydrogenase reductase Sdr
C663_2088	COG1199	ATP-dependent helicase activity
C663_2090	COG0116	Belongs to the methyltransferase superfamily
C663_2092	COG4474	Belongs to the UPF0398 family
C663_2094	COG3359	exonuclease
C663_2095	COG1111	helicase
C663_2095	COG1205	dead DEAH box helicase
C663_2096	COG2190	(PTS) system
C663_2097	COG0071	Belongs to the small heat shock protein (HSP20) family
C663_2104	COG3331	DNA recombination
C663_2105	COG4499	WXG100 protein secretion system (Wss), protein YukC
C663_2105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C663_2107	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C663_2108	COG3935	DnaD domain protein
C663_2109	COG0017	Asparaginyl-tRNA synthetase
C663_2110	COG0436	Aminotransferase
C663_2111	COG5353	protein conserved in bacteria
C663_2113	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C663_2113	COG1199	ATP-dependent helicase activity
C663_2114	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C663_2115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C663_2116	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C663_2117	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C663_2117	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C663_2118	COG0617	tRNA 3'-terminal CCA addition
C663_2119	COG0438	transferase activity, transferring glycosyl groups
C663_2120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C663_2121	COG1803	Methylglyoxal synthase
C663_2122	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C663_2123	COG1694	Mazg nucleotide pyrophosphohydrolase
C663_2124	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C663_2126	COG4347	Protein of unknown function (DUF1405)
C663_2127	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C663_2127	COG2010	Cytochrome c
C663_2128	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C663_2129	COG0723	plastoquinol--plastocyanin reductase activity
C663_2131	COG5582	Belongs to the UPF0302 family
C663_2132	COG0457	Tetratricopeptide repeat
C663_2133	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C663_2134	COG0287	Prephenate dehydrogenase
C663_2135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C663_2136	COG0159	tryptophan synthase activity
C663_2137	COG0133	tryptophan synthase activity
C663_2138	COG0135	phosphoribosylanthranilate isomerase activity
C663_2140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C663_2141	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C663_2142	COG4401	Chorismate mutase type I
C663_2143	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C663_2144	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C663_2145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C663_2146	COG0105	UTP biosynthetic process
C663_2148	COG2226	methyltransferase
C663_2149	COG0142	geranyltranstransferase activity
C663_2151	COG0302	gtp cyclohydrolase
C663_2152	COG0776	regulation of translation
C663_2153	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C663_2156	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C663_2157	COG1160	GTP binding
C663_2162	COG1304	FMN binding
C663_2163	COG0539	negative regulation of cytoplasmic translation
C663_2164	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C663_2166	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C663_2167	COG2959	enzyme of heme biosynthesis
C663_2168	COG3409	Peptidoglycan-binding domain 1 protein
C663_2168	COG3773	Cell wall hydrolase
C663_2169	COG2339	peptidase activity
C663_2170	COG0492	ferredoxin-NADP+ reductase activity
C663_2172	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C663_2174	COG4862	establishment of competence for transformation
C663_2175	COG1408	metallophosphoesterase
C663_2177	COG1388	LysM domain
C663_2179	COG0514	ATP-dependent DNA helicase (RecQ)
C663_2180	COG4955	Helix-turn-helix domain
C663_2181	COG1141	Ferredoxin
C663_2182	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C663_2184	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C663_2185	COG0710	3-dehydroquinate dehydratase activity
C663_2187	COG1595	DNA-templated transcription, initiation
C663_2188	COG5002	protein histidine kinase activity
C663_2189	COG0745	RESPONSE REGULATOR receiver
C663_2190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C663_2191	COG1333	cytochrome c biogenesis protein
C663_2192	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C663_2193	COG1187	pseudouridine synthase activity
C663_2194	COG0700	Nucleoside recognition
C663_2195	COG2715	membrane protein required for spore maturation
C663_2196	COG1686	Belongs to the peptidase S11 family
C663_2198	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C663_2199	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C663_2200	COG1547	Domain of unknown function (DUF309)
C663_2201	COG0456	acetyltransferase
C663_2202	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C663_2203	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C663_2203	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C663_2204	COG0307	riboflavin synthase, alpha
C663_2205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C663_2205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C663_2207	COG0681	Belongs to the peptidase S26 family
C663_2211	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C663_2212	COG4086	secreted protein
C663_2213	COG0019	diaminopimelate decarboxylase activity
C663_2214	COG0697	spore germination
C663_2217	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C663_2221	COG1191	sigma factor activity
C663_2222	COG2172	sigma factor antagonist activity
C663_2223	COG1366	Belongs to the anti-sigma-factor antagonist family
C663_2224	COG1686	Belongs to the peptidase S11 family
C663_2225	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C663_2226	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C663_2227	COG4974	Belongs to the 'phage' integrase family
C663_2229	COG0735	belongs to the Fur family
C663_2230	COG1300	Membrane
C663_2232	COG0281	malic enzyme
C663_2233	COG1757	Na H antiporter
C663_2234	COG1027	Aspartate ammonia-lyase
C663_2235	COG0252	asparaginase activity
C663_2236	COG1396	sequence-specific DNA binding
C663_2239	COG0494	nUDIX hydrolase
C663_2241	COG0667	Aldo Keto reductase
C663_2243	COG1073	alpha beta
C663_2245	COG4918	Iron-sulphur cluster biosynthesis
C663_2246	COG0456	acetyltransferase
C663_2246	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C663_2247	COG2329	Antibiotic biosynthesis monooxygenase
C663_2248	COG0456	acetyltransferase
C663_2250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C663_2253	COG2211	Major facilitator Superfamily
C663_2255	COG0346	lactoylglutathione lyase activity
C663_2256	COG1072	(Pantothenic acid kinase))
C663_2257	COG3048	D-serine ammonia-lyase activity
C663_2258	COG0300	oxidoreductase activity
C663_2259	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C663_2260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C663_2261	COG4187	Peptidase family M20/M25/M40
C663_2262	COG1902	pentaerythritol trinitrate reductase activity
C663_2263	COG0596	Alpha beta hydrolase
C663_2265	COG1234	tRNA 3'-trailer cleavage
C663_2266	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C663_2267	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C663_2268	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C663_2270	COG0706	membrane insertase activity
C663_2271	COG3361	conserved protein (COG2071)
C663_2272	COG2195	Cleaves the N-terminal amino acid of tripeptides
C663_2273	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C663_2274	COG0346	lactoylglutathione lyase activity
C663_2275	COG1376	ErfK ybiS ycfS ynhG family protein
C663_2276	COG4129	membrane
C663_2277	COG1126	abc transporter atp-binding protein
C663_2278	COG0765	amino acid transport
C663_2279	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C663_2280	COG1597	lipid kinase activity
C663_2282	COG2814	Major facilitator Superfamily
C663_2283	COG4978	Transcriptional regulator
C663_2283	COG0789	Transcriptional regulator
C663_2284	COG0508	dehydrogenase complex catalyzes the overall conversion of
C663_2285	COG0022	dehydrogenase e1 component
C663_2286	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C663_2287	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C663_2288	COG3426	butyrate kinase activity
C663_2289	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C663_2290	COG0280	phosphate acetyltransferase
C663_2291	COG3829	transcription factor binding
C663_2291	COG3290	protein histidine kinase activity
C663_2293	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C663_2294	COG2079	MmgE PrpD family protein
C663_2295	COG0372	Belongs to the citrate synthase family
C663_2296	COG1960	acyl-CoA dehydrogenase activity
C663_2297	COG1250	3-hydroxyacyl-CoA dehydrogenase
C663_2298	COG0183	Belongs to the thiolase family
C663_2299	COG0584	glycerophosphoryl diester phosphodiesterase
C663_2300	COG0860	N-Acetylmuramoyl-L-alanine amidase
C663_2303	COG1902	pentaerythritol trinitrate reductase activity
C663_2304	COG0745	RESPONSE REGULATOR receiver
C663_2306	COG0497	DNA recombination
C663_2307	COG1438	arginine binding
C663_2308	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C663_2309	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C663_2310	COG0142	geranyltranstransferase activity
C663_2312	COG1722	exodeoxyribonuclease VII activity
C663_2313	COG1570	exodeoxyribonuclease VII activity
C663_2314	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C663_2315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C663_2316	COG1302	Protein conserved in bacteria
C663_2317	COG0439	Biotin carboxylase
C663_2318	COG0511	ligase activity, forming carbon-carbon bonds
C663_2326	COG3854	ATPases associated with a variety of cellular activities
C663_2328	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C663_2329	COG0006	proline dipeptidase activity
C663_2330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C663_2332	COG3872	metal-dependent enzyme
C663_2334	COG1752	Esterase of the alpha-beta hydrolase superfamily
C663_2335	COG1321	iron dependent repressor
C663_2336	COG0095	Lipoate-protein ligase
C663_2337	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C663_2338	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C663_2339	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C663_2340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C663_2341	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C663_2344	COG1396	sequence-specific DNA binding
C663_2346	COG0681	Belongs to the peptidase S26 family
C663_2351	COG4940	Competence protein ComGF
C663_2353	COG4970	Tfp pilus assembly protein FimT
C663_2354	COG4537	Required for transformation and DNA binding
C663_2356	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C663_2358	COG0598	Magnesium transport protein CorA
C663_2359	COG1253	flavin adenine dinucleotide binding
C663_2360	COG1366	Belongs to the anti-sigma-factor antagonist family
C663_2361	COG1393	Belongs to the ArsC family
C663_2363	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C663_2365	COG0011	TIGRFAM Protein of
C663_2367	COG2866	Carboxypeptidase
C663_2368	COG1368	sulfuric ester hydrolase activity
C663_2369	COG1940	carbohydrate kinase activity
C663_2370	COG4483	Protein conserved in bacteria
C663_2371	COG0457	Tetratricopeptide repeat
C663_2371	COG0705	Rhomboid family
C663_2373	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C663_2374	COG0438	transferase activity, transferring glycosyl groups
C663_2377	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C663_2378	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C663_2379	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C663_2380	COG0581	inorganic phosphate transmembrane transporter activity
C663_2381	COG0573	inorganic phosphate transmembrane transporter activity
C663_2382	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C663_2384	COG0477	Major facilitator Superfamily
C663_2385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C663_2386	COG2839	Protein conserved in bacteria
C663_2387	COG5521	maltodextrose utilization protein MalA
C663_2388	COG1388	LysM domain
C663_2389	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C663_2390	COG4709	membrane
C663_2391	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C663_2392	COG0735	belongs to the Fur family
C663_2393	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C663_2395	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C663_2396	COG0513	Belongs to the DEAD box helicase family
C663_2398	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C663_2399	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C663_2400	COG2384	SAM-dependent methyltransferase
C663_2401	COG2010	Cytochrome c
C663_2402	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C663_2403	COG0358	DNA primase activity
C663_2404	COG1671	Belongs to the UPF0178 family
C663_2405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C663_2406	COG0517	IMP dehydrogenase activity
C663_2407	COG0751	glycine-tRNA ligase activity
C663_2408	COG0752	glycyl-tRNA synthetase alpha subunit
C663_2409	COG1381	Involved in DNA repair and RecF pathway recombination
C663_2411	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C663_2412	COG0295	cytidine deaminase activity
C663_2413	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C663_2414	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C663_2415	COG1480	7TM receptor with intracellular HD hydrolase
C663_2416	COG1702	phosphate starvation-inducible protein PhoH
C663_2417	COG0561	phosphatase activity
C663_2420	COG4864	UPF0365 protein
C663_2421	COG1030	water channel activity
C663_2422	COG1610	YqeY-like protein
C663_2423	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C663_2424	COG1283	sodium-dependent phosphate transmembrane transporter activity
C663_2425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C663_2426	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C663_2427	COG2264	protein methyltransferase activity
C663_2428	COG0484	heat shock protein binding
C663_2429	COG0443	Heat shock 70 kDa protein
C663_2430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C663_2431	COG1420	regulation of RNA biosynthetic process
C663_2432	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C663_2435	COG0860	N-Acetylmuramoyl-L-alanine amidase
C663_2436	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C663_2437	COG0268	Binds directly to 16S ribosomal RNA
C663_2438	COG1466	dna polymerase III delta subunit
C663_2441	COG2333	competence protein COMEC
C663_2441	COG0658	competence protein
C663_2442	COG2131	deaminase
C663_2443	COG1555	photosystem II stabilization
C663_2443	COG1596	polysaccharide export
C663_2444	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C663_2445	COG2226	methyltransferase
C663_2446	COG0799	negative regulation of ribosome biogenesis
C663_2447	COG1713	HD superfamily hydrolase involved in NAD metabolism
C663_2448	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C663_2449	COG1534	Rna-binding protein
C663_2450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C663_2451	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C663_2452	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C663_2454	COG2755	lipolytic protein G-D-S-L family
C663_2456	COG0398	Pfam SNARE associated Golgi protein
C663_2457	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C663_2459	COG3209	COG3209 Rhs family protein
C663_2463	COG3223	Belongs to the PsiE family
C663_2464	COG5002	protein histidine kinase activity
C663_2464	COG0642	Histidine kinase
C663_2465	COG0745	RESPONSE REGULATOR receiver
C663_2466	COG2311	Membrane
C663_2468	COG0454	-acetyltransferase
C663_2469	COG1733	regulation of RNA biosynthetic process
C663_2470	COG1028	Short-chain dehydrogenase reductase Sdr
C663_2480	COG0563	adenylate kinase activity
C663_2483	COG2249	NAD(P)H dehydrogenase (quinone) activity
C663_2485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C663_2488	COG5444	nuclease activity
C663_2494	COG4978	Transcriptional regulator
C663_2494	COG0789	Transcriptional regulator
C663_2495	COG2814	Major facilitator Superfamily
C663_2496	COG0456	acetyltransferase
C663_2497	COG1253	flavin adenine dinucleotide binding
C663_2499	COG0697	spore germination
C663_2500	COG0583	DNA-binding transcription factor activity
C663_2501	COG2072	flavoprotein involved in K transport
C663_2502	COG1230	cation diffusion facilitator family transporter
C663_2503	COG1942	4-Oxalocrotonate Tautomerase
C663_2504	COG0583	DNA-binding transcription factor activity
C663_2505	COG1114	Component of the transport system for branched-chain amino acids
C663_2506	COG1687	branched-chain amino acid
C663_2507	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C663_2508	COG1522	sequence-specific DNA binding
C663_2509	COG2732	(Barnase) inhibitor
C663_2510	COG2124	cytochrome p450
C663_2512	COG1335	isochorismatase
C663_2514	COG2318	DinB family
C663_2516	COG2070	2-Nitropropane dioxygenase
C663_2517	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C663_2519	COG3443	Belongs to the bacterial solute-binding protein 9 family
C663_2520	COG1595	DNA-templated transcription, initiation
C663_2521	COG0667	Aldo Keto reductase
C663_2522	COG3409	Peptidoglycan-binding domain 1 protein
C663_2523	COG5566	PFAM Mor transcription activator
C663_2524	COG0596	Alpha beta hydrolase
C663_2525	COG4991	sh3 domain protein
C663_2526	COG4991	sh3 domain protein
C663_2527	COG0346	lactoylglutathione lyase activity
C663_2529	COG5577	PFAM Coat F domain
C663_2530	COG1063	alcohol dehydrogenase
C663_2532	COG5577	PFAM Coat F domain
C663_2533	COG0789	Transcriptional regulator
C663_2535	COG1064	alcohol dehydrogenase
C663_2536	COG0693	protein deglycase activity
C663_2537	COG1621	beta-fructofuranosidase activity
C663_2538	COG3716	PTS system mannose fructose sorbose family IID component
C663_2539	COG3715	PTS system
C663_2540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_2541	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C663_2542	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C663_2542	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C663_2543	COG1113	amino acid transport
C663_2544	COG1280	lysine exporter protein (LysE YggA)
C663_2545	COG1378	Sugar-specific transcriptional regulator TrmB
C663_2548	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C663_2548	COG2755	lipolytic protein G-D-S-L family
C663_2550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C663_2550	COG2124	cytochrome p450
C663_2551	COG1309	transcriptional regulator
C663_2552	COG2226	methyltransferase
C663_2557	COG2116	formate transmembrane transporter activity
C663_2558	COG5609	conserved protein (DUF2294)
C663_2559	COG3383	formate dehydrogenase (NAD+) activity
C663_2560	COG2427	Protein of unknown function (DUF1641)
C663_2562	COG0626	cystathionine gamma-synthase activity
C663_2563	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C663_2564	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C663_2565	COG2226	methyltransferase
C663_2568	COG0768	penicillin binding
C663_2569	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C663_2570	COG0572	uridine kinase
C663_2574	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C663_2575	COG3906	Belongs to the UPF0473 family
C663_2576	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C663_2577	COG4472	Bacterial protein of unknown function (DUF965)
C663_2578	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C663_2579	COG0628	permease
C663_2580	COG1126	abc transporter atp-binding protein
C663_2581	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C663_2582	COG0765	amino acid transport
C663_2583	COG0765	amino acid transport
C663_2586	COG3881	PFAM PRC-barrel domain
C663_2587	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C663_2588	COG0457	Tetratricopeptide repeat
C663_2589	COG0482	sulfurtransferase activity
C663_2590	COG1104	cysteine desulfurase activity
C663_2591	COG1959	2 iron, 2 sulfur cluster binding
C663_2592	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C663_2593	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C663_2595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C663_2596	COG0124	histidyl-tRNA synthetase
C663_2597	COG4991	sh3 domain protein
C663_2597	COG0860	N-Acetylmuramoyl-L-alanine amidase
C663_2597	COG3103	Sh3 type 3 domain protein
C663_2599	COG1490	D-aminoacyl-tRNA deacylase activity
C663_2600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C663_2601	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C663_2602	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C663_2602	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C663_2603	COG5416	Lipopolysaccharide assembly protein A domain
C663_2604	COG0490	domain, Protein
C663_2605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C663_2605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C663_2607	COG2244	polysaccharide biosynthetic process
C663_2608	COG2323	membrane
C663_2610	COG1862	Preprotein translocase
C663_2611	COG0343	queuine tRNA-ribosyltransferase activity
C663_2612	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C663_2614	COG2255	four-way junction helicase activity
C663_2615	COG0632	four-way junction helicase activity
C663_2617	COG2814	Major facilitator Superfamily
C663_2618	COG0673	inositol 2-dehydrogenase activity
C663_2619	COG2112	serine threonine protein kinase
C663_2622	COG1115	amino acid carrier protein
C663_2623	COG0217	transcriptional regulatory protein
C663_2625	COG1388	LysM domain
C663_2626	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C663_2628	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C663_2629	COG1104	cysteine desulfurase activity
C663_2630	COG1827	regulation of RNA biosynthetic process
C663_2631	COG0077	Prephenate dehydratase
C663_2632	COG4492	Belongs to the UPF0735 family
C663_2633	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C663_2634	COG3290	protein histidine kinase activity
C663_2636	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C663_2637	COG2868	ribosomal protein
C663_2638	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C663_2639	COG1994	Peptidase M50
C663_2640	COG0739	heme binding
C663_2641	COG2894	cell division
C663_2642	COG0850	regulation of cytokinetic process
C663_2643	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C663_2644	COG1792	Involved in formation and maintenance of cell shape
C663_2645	COG1077	Cell shape determining protein MreB Mrl
C663_2646	COG2003	Belongs to the UPF0758 family
C663_2647	COG0424	maF-like protein
C663_2649	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C663_2650	COG0285	dihydrofolate synthase activity
C663_2651	COG0525	valine-tRNA ligase activity
C663_2653	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C663_2654	COG1388	LysM domain
C663_2655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C663_2656	COG0113	porphobilinogen synthase activity
C663_2658	COG0181	hydroxymethylbilane synthase activity
C663_2659	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C663_2660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C663_2662	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C663_2663	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C663_2664	COG1067	ATP-dependent peptidase activity
C663_2664	COG0470	DNA polymerase III
C663_2665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C663_2666	COG0544	peptidyl-prolyl cis-trans isomerase activity
C663_2667	COG0457	Tetratricopeptide repeat
C663_2667	COG1477	protein flavinylation
C663_2668	COG0066	3-isopropylmalate dehydratase activity
C663_2669	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C663_2670	COG0473	3-isopropylmalate dehydrogenase activity
C663_2671	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C663_2672	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C663_2673	COG0440	acetolactate synthase activity
C663_2674	COG0028	Belongs to the TPP enzyme family
C663_2677	COG0454	-acetyltransferase
C663_2678	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C663_2679	COG0622	Phosphoesterase
C663_2680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C663_2681	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C663_2682	COG5401	PFAM Sporulation and spore germination
C663_2683	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C663_2684	COG1846	Transcriptional regulator
C663_2685	COG2197	response regulator
C663_2686	COG0824	Thioesterase
C663_2687	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C663_2688	COG1053	succinate dehydrogenase
C663_2689	COG2009	succinate dehydrogenase
C663_2690	COG1719	4-vinyl reductase, 4VR
C663_2691	COG0527	aspartate kinase activity
C663_2692	COG0322	excinuclease ABC activity
C663_2693	COG3118	belongs to the thioredoxin family
C663_2695	COG3534	alpha-L-arabinofuranosidase
C663_2697	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C663_2698	COG2086	electron transfer activity
C663_2699	COG1024	Enoyl-CoA hydratase
C663_2700	COG1309	transcriptional regulator
C663_2701	COG0318	PFAM AMP-dependent synthetase and ligase
C663_2702	COG3766	membrane
C663_2703	COG1193	negative regulation of DNA recombination
C663_2704	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C663_2704	COG1796	DNA polymerase
C663_2705	COG1286	toxin biosynthetic process
C663_2706	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C663_2707	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C663_2708	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C663_2708	COG0072	phenylalanine-tRNA ligase activity
C663_2709	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C663_2710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C663_2712	COG3835	regulator
C663_2713	COG0277	FAD linked oxidase domain protein
C663_2714	COG0247	lactate metabolic process
C663_2715	COG0346	lactoylglutathione lyase activity
C663_2716	COG1966	Carbon starvation protein
C663_2717	COG3534	alpha-L-arabinofuranosidase
C663_2718	COG0395	ABC-type sugar transport system, permease component
C663_2719	COG1175	transmembrane transport
C663_2720	COG1653	transport
C663_2721	COG0371	Dehydrogenase
C663_2722	COG0647	UMP catabolic process
C663_2723	COG0235	Class ii aldolase
C663_2724	COG1069	ribulokinase activity
C663_2725	COG2160	L-arabinose isomerase activity
C663_2727	COG3507	Belongs to the glycosyl hydrolase 43 family
C663_2730	COG3326	Membrane
C663_2731	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C663_2732	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C663_2733	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C663_2735	COG1346	cytolysis
C663_2736	COG1380	Effector of murein hydrolase LrgA
C663_2737	COG3279	Response regulator of the LytR AlgR family
C663_2738	COG3275	phosphorelay sensor kinase activity
C663_2740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C663_2742	COG0398	Pfam SNARE associated Golgi protein
C663_2743	COG1484	DNA-dependent DNA replication
C663_2744	COG3611	Membrane attachment protein
C663_2745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C663_2746	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C663_2747	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C663_2748	COG1733	regulation of RNA biosynthetic process
C663_2749	COG2814	Major facilitator Superfamily
C663_2750	COG0656	L-ascorbic acid biosynthetic process
C663_2751	COG0237	dephospho-CoA kinase activity
C663_2752	COG1971	Probably functions as a manganese efflux pump
C663_2753	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C663_2754	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C663_2754	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C663_2755	COG5002	protein histidine kinase activity
C663_2756	COG0745	RESPONSE REGULATOR receiver
C663_2757	COG0039	L-malate dehydrogenase activity
C663_2758	COG0538	isocitrate dehydrogenase activity
C663_2759	COG0372	Belongs to the citrate synthase family
C663_2760	COG2707	UPF0756 membrane protein
C663_2761	COG0628	permease
C663_2763	COG0469	pyruvate kinase activity
C663_2764	COG0205	6-phosphofructokinase activity
C663_2765	COG0825	malonyl-CoA metabolic process
C663_2766	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C663_2767	COG0281	malic enzyme
C663_2768	COG0587	DNA-directed DNA polymerase activity
C663_2772	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C663_2774	COG4109	DRTGG domain
C663_2775	COG0730	response to heat
C663_2776	COG1473	amidohydrolase
C663_2777	COG0196	riboflavin kinase activity
C663_2778	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C663_2779	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C663_2780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C663_2781	COG1126	abc transporter atp-binding protein
C663_2782	COG0765	amino acid transport
C663_2783	COG0765	amino acid transport
C663_2784	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C663_2785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C663_2786	COG0454	-acetyltransferase
C663_2787	COG0583	DNA-binding transcription factor activity
C663_2788	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C663_2789	COG1028	Short-chain dehydrogenase reductase Sdr
C663_2791	COG0165	Argininosuccinate lyase
C663_2792	COG0137	argininosuccinate synthase activity
C663_2793	COG0521	Mo-molybdopterin cofactor biosynthetic process
C663_2794	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C663_2795	COG0827	DNA restriction-modification system
C663_2796	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C663_2797	COG3874	Sporulation protein YtfJ
C663_2799	COG0616	signal peptide processing
C663_2800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C663_2801	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C663_2802	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C663_2804	COG0301	tRNA thio-modification
C663_2805	COG1104	cysteine desulfurase activity
C663_2806	COG1114	Component of the transport system for branched-chain amino acids
C663_2807	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C663_2808	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C663_2809	COG1309	transcriptional regulator
C663_2810	COG1956	GAF domain-containing protein
C663_2811	COG2199	diguanylate cyclase activity
C663_2811	COG2203	Gaf domain
C663_2813	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C663_2815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C663_2816	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C663_2817	COG0454	-acetyltransferase
C663_2819	COG0123	including yeast histone deacetylase and acetoin utilization protein
C663_2820	COG1360	Flagellar Motor Protein
C663_2821	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C663_2822	COG1609	Transcriptional regulator
C663_2823	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C663_2823	COG1605	Chorismate mutase
C663_2824	COG3118	belongs to the thioredoxin family
C663_2825	COG4980	gas vesicle protein
C663_2826	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C663_2827	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C663_2828	COG1674	ftsk spoiiie
C663_2829	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C663_2830	COG4848	Belongs to the UPF0354 family
C663_2831	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C663_2833	COG1363	Peptidase, m42
C663_2834	COG5584	Small secreted protein
C663_2835	COG0281	malic enzyme
C663_2836	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C663_2837	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C663_2839	COG0510	thiamine kinase activity
C663_2840	COG1523	belongs to the glycosyl hydrolase 13 family
C663_2841	COG1597	lipid kinase activity
C663_2843	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C663_2844	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C663_2845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C663_2846	COG2252	PERMEase
C663_2847	COG4473	ABC transporter
C663_2848	COG1131	(ABC) transporter
C663_2849	COG1349	DNA-binding transcription factor activity
C663_2850	COG1187	pseudouridine synthase activity
C663_2851	COG2244	polysaccharide biosynthetic process
C663_2852	COG2081	HI0933 family
C663_2853	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C663_2855	COG5578	integral membrane protein
C663_2856	COG0673	inositol 2-dehydrogenase activity
C663_2857	COG1653	transport
C663_2858	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C663_2859	COG4209	transmembrane transport
C663_2860	COG2207	Transcriptional regulator
C663_2861	COG1653	transport
C663_2862	COG0395	ABC-type sugar transport system, permease component
C663_2863	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C663_2864	COG2124	cytochrome p450
C663_2865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C663_2867	COG0156	8-amino-7-oxononanoate synthase activity
C663_2868	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C663_2870	COG1073	alpha beta
C663_2877	COG1486	melibiose metabolic process
C663_2878	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C663_2879	COG0495	leucyl-tRNA aminoacylation
C663_2881	COG2202	Pas domain
C663_2881	COG1366	Belongs to the anti-sigma-factor antagonist family
C663_2882	COG2814	Major facilitator Superfamily
C663_2883	COG2433	Pfam Transposase IS66
C663_2884	COG0577	efflux transmembrane transporter activity
C663_2885	COG1136	(ABC) transporter
C663_2886	COG2205	protein histidine kinase activity
C663_2887	COG0745	RESPONSE REGULATOR receiver
C663_2888	COG0577	efflux transmembrane transporter activity
C663_2889	COG1136	(ABC) transporter
C663_2892	COG1131	(ABC) transporter
C663_2893	COG1725	Transcriptional regulator
C663_2896	COG1242	4 iron, 4 sulfur cluster binding
C663_2897	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C663_2899	COG2267	carboxylic ester hydrolase activity
C663_2900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C663_2901	COG1113	amino acid transport
C663_2903	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C663_2905	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C663_2907	COG1506	peptidase
C663_2908	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C663_2909	COG1116	anion transmembrane transporter activity
C663_2910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C663_2911	COG0494	nUDIX hydrolase
C663_2913	COG0783	Belongs to the Dps family
C663_2916	COG1854	S-ribosylhomocysteine lyase activity
C663_2917	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C663_2918	COG0288	reversible hydration of carbon dioxide
C663_2919	COG0254	rRNA binding
C663_2921	COG1294	oxidase, subunit
C663_2923	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C663_2924	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C663_2924	COG1321	iron dependent repressor
C663_2925	COG1121	(ABC) transporter
C663_2926	COG0803	Belongs to the bacterial solute-binding protein 9 family
C663_2927	COG4948	Mandelate Racemase Muconate Lactonizing
C663_2929	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C663_2930	COG0596	Alpha beta hydrolase
C663_2931	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C663_2932	COG1169	isochorismate synthase
C663_2933	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C663_2934	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C663_2935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C663_2936	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C663_2937	COG0438	transferase activity, transferring glycosyl groups
C663_2939	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C663_2940	COG0438	transferase activity, transferring glycosyl groups
C663_2941	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C663_2942	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C663_2943	COG0058	SHG alpha-glucan phosphorylase activity
C663_2944	COG0297	glycogen (starch) synthase activity
C663_2946	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C663_2947	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C663_2949	COG3859	Proton-coupled thiamine transporter YuaJ
C663_2950	COG1247	-acetyltransferase
C663_2951	COG1247	-acetyltransferase
C663_2952	COG2268	Band 7 protein
C663_2953	COG1585	Membrane protein implicated in regulation of membrane protease activity
C663_2954	COG2318	DinB family
C663_2956	COG1454	alcohol dehydrogenase
C663_2958	COG1510	regulation of RNA biosynthetic process
C663_2960	COG0569	domain protein
C663_2963	COG4682	membrane
C663_2964	COG1705	Flagellar rod assembly protein muramidase FlgJ
C663_2965	COG0477	Major facilitator Superfamily
C663_2966	COG5553	Cysteine dioxygenase type I
C663_2968	COG1968	undecaprenyl-diphosphatase activity
C663_2969	COG0628	permease
C663_2970	COG0673	inositol 2-dehydrogenase activity
C663_2971	COG4806	L-rhamnose isomerase
C663_2972	COG3254	rhamnose metabolic process
C663_2973	COG1070	Carbohydrate kinase
C663_2974	COG1349	DNA-binding transcription factor activity
C663_2975	COG3347	Dehydrogenase
C663_2975	COG1028	Short-chain dehydrogenase reductase Sdr
C663_2977	COG0840	transmembrane signaling receptor activity
C663_2978	COG0840	transmembrane signaling receptor activity
C663_2979	COG0840	transmembrane signaling receptor activity
C663_2980	COG0840	transmembrane signaling receptor activity
C663_2984	COG0432	Pfam Uncharacterised protein family UPF0047
C663_2986	COG0366	Alpha amylase catalytic
C663_2987	COG1253	flavin adenine dinucleotide binding
C663_2988	COG2738	Putative neutral zinc metallopeptidase
C663_2991	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C663_2994	COG0166	Belongs to the GPI family
C663_2995	COG1979	alcohol dehydrogenase
C663_2997	COG1979	alcohol dehydrogenase
C663_2998	COG2155	Conserved Protein
C663_2999	COG1098	S1 RNA binding domain
C663_3000	COG0436	Aminotransferase
C663_3001	COG1522	sequence-specific DNA binding
C663_3002	COG2267	carboxylic ester hydrolase activity
C663_3004	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C663_3005	COG2205	protein histidine kinase activity
C663_3007	COG5018	Exonuclease
C663_3009	COG2814	Major facilitator Superfamily
C663_3010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C663_3011	COG3011	Protein conserved in bacteria
C663_3013	COG3290	protein histidine kinase activity
C663_3014	COG4565	transcriptional regulatory protein
C663_3019	COG3493	citrate carrier protein
C663_3021	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C663_3021	COG2111	Na H antiporter
C663_3022	COG2111	Na H antiporter
C663_3023	COG1006	Multisubunit Na H antiporter MnhC subunit
C663_3024	COG0651	ATP synthesis coupled electron transport
C663_3025	COG1863	multisubunit Na H antiporter MnhE subunit
C663_3026	COG2212	antiporter activity
C663_3027	COG1320	monovalent cation:proton antiporter activity
C663_3028	COG2050	protein possibly involved in aromatic compounds catabolism
C663_3030	COG4585	Histidine kinase
C663_3032	COG0142	geranyltranstransferase activity
C663_3035	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C663_3036	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C663_3037	COG1335	isochorismatase
C663_3038	COG5506	Protein of unknown function (DUF1694)
C663_3041	COG0628	permease
C663_3043	COG1418	mRNA catabolic process
C663_3044	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3046	COG1511	domain protein
C663_3047	COG1674	ftsk spoiiie
C663_3047	COG0433	COG0433 Predicted ATPase
C663_3048	COG4499	WXG100 protein secretion system (Wss), protein YukC
C663_3049	COG5417	Belongs to the EsaB family
C663_3050	COG4842	Belongs to the WXG100 family
C663_3051	COG2508	Transcriptional regulator
C663_3051	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C663_3052	COG0686	Belongs to the AlaDH PNT family
C663_3053	COG5634	Uncharacterized conserved protein (DUF2278)
C663_3054	COG3251	PFAM MbtH domain protein
C663_3055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_3056	COG1535	isochorismatase
C663_3056	COG3433	isochorismatase activity
C663_3057	COG1021	2,3-dihydroxybenzoate-AMP ligase
C663_3058	COG1169	isochorismate synthase
C663_3059	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3060	COG2819	hydrolase of the alpha beta superfamily
C663_3061	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C663_3062	COG1268	BioY protein
C663_3063	COG2056	Na+-H+ antiporter family
C663_3064	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C663_3065	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C663_3066	COG3584	3D domain protein
C663_3069	COG1252	NADH dehydrogenase
C663_3070	COG0492	ferredoxin-NADP+ reductase activity
C663_3071	COG0516	GMP reductase activity
C663_3072	COG2808	Putative FMN-binding domain
C663_3073	COG0456	acetyltransferase
C663_3074	COG0316	Belongs to the HesB IscA family
C663_3075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C663_3076	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C663_3077	COG4844	belongs to the
C663_3078	COG1252	NADH dehydrogenase
C663_3079	COG4837	Protein of unknown function (DUF1462)
C663_3080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C663_3081	COG0823	Involved in the tonB-independent uptake of proteins
C663_3081	COG4946	Tricorn protease homolog
C663_3081	COG1506	peptidase
C663_3082	COG0083	homoserine kinase activity
C663_3083	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C663_3084	COG0460	homoserine dehydrogenase
C663_3085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C663_3086	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C663_3087	COG0647	UMP catabolic process
C663_3088	COG2445	Protein of unknown function DUF86
C663_3089	COG4470	Protein conserved in bacteria
C663_3091	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C663_3092	COG0739	heme binding
C663_3094	COG3377	Domain of unknown function (DUF1805)
C663_3095	COG0737	Belongs to the 5'-nucleotidase family
C663_3096	COG0730	response to heat
C663_3097	COG1801	Protein of unknown function DUF72
C663_3099	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C663_3100	COG2508	Transcriptional regulator
C663_3101	COG2233	PERMEase
C663_3102	COG2233	PERMEase
C663_3103	COG3648	Uricase
C663_3103	COG3195	allantoin biosynthetic process
C663_3104	COG2351	hydroxyisourate hydrolase activity
C663_3107	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C663_3108	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C663_3109	COG2068	MobA-Related Protein
C663_3110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C663_3111	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C663_3112	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C663_3113	COG2356	endonuclease I
C663_3114	COG3842	ATPase activity
C663_3115	COG2188	Transcriptional regulator
C663_3116	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C663_3117	COG0395	ABC-type sugar transport system, permease component
C663_3118	COG1175	transmembrane transport
C663_3119	COG1653	transport
C663_3120	COG2222	sugar isomerase
C663_3121	COG0322	excinuclease ABC activity
C663_3122	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C663_3125	COG0346	lactoylglutathione lyase activity
C663_3126	COG0719	Fe-S assembly protein
C663_3127	COG0822	iron-sulfur transferase activity
C663_3128	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C663_3129	COG0719	Fe-S assembly protein
C663_3130	COG0396	ATPase activity
C663_3132	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C663_3133	COG1464	Belongs to the NlpA lipoprotein family
C663_3134	COG2011	ABC-type metal ion transport system permease component
C663_3135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C663_3138	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C663_3139	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C663_3141	COG0509	glycine decarboxylation via glycine cleavage system
C663_3142	COG1393	Belongs to the ArsC family
C663_3143	COG1960	acyl-CoA dehydrogenase activity
C663_3144	COG0183	Belongs to the thiolase family
C663_3145	COG1250	3-hydroxyacyl-CoA dehydrogenase
C663_3145	COG1024	Enoyl-CoA hydratase
C663_3147	COG0506	proline dehydrogenase activity
C663_3149	COG5577	PFAM Coat F domain
C663_3150	COG1846	Transcriptional regulator
C663_3151	COG0477	Major facilitator Superfamily
C663_3152	COG1942	4-Oxalocrotonate Tautomerase
C663_3153	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3154	COG0583	DNA-binding transcription factor activity
C663_3156	COG1120	ATPase activity
C663_3159	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3160	COG0783	Belongs to the Dps family
C663_3161	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C663_3163	COG0745	RESPONSE REGULATOR receiver
C663_3164	COG2770	Histidine kinase
C663_3164	COG2205	protein histidine kinase activity
C663_3166	COG1309	transcriptional regulator
C663_3167	COG0114	fumarate hydratase activity
C663_3169	COG0697	spore germination
C663_3170	COG0814	amino acid
C663_3172	COG2197	response regulator
C663_3173	COG4585	Histidine kinase
C663_3174	COG4758	membrane
C663_3175	COG3595	metallopeptidase activity
C663_3176	COG1842	Phage shock protein A
C663_3177	COG4758	membrane
C663_3178	COG2814	Major facilitator Superfamily
C663_3180	COG2096	Adenosyltransferase
C663_3181	COG1120	ATPase activity
C663_3182	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C663_3183	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C663_3184	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3185	COG3386	PFAM SMP-30 Gluconolaconase
C663_3186	COG2205	protein histidine kinase activity
C663_3187	COG0745	RESPONSE REGULATOR receiver
C663_3189	COG1191	sigma factor activity
C663_3192	COG2140	Oxalate decarboxylase
C663_3194	COG0577	efflux transmembrane transporter activity
C663_3195	COG1136	(ABC) transporter
C663_3196	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C663_3197	COG1120	ATPase activity
C663_3198	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C663_3200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C663_3202	COG0531	amino acid
C663_3204	COG1988	membrane-bound metal-dependent
C663_3205	COG1368	sulfuric ester hydrolase activity
C663_3206	COG1910	domain protein
C663_3207	COG0725	ABC transporter, periplasmic molybdate-binding protein
C663_3208	COG4149	molybdate abc transporter
C663_3209	COG0656	L-ascorbic acid biosynthetic process
C663_3211	COG0025	NhaP-type Na H and K H
C663_3212	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C663_3213	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C663_3214	COG3973	AAA domain
C663_3216	COG2860	membrane
C663_3217	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C663_3218	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C663_3219	COG2217	Heavy metal translocating P-type atpase
C663_3220	COG2217	Heavy metal translocating P-type atpase
C663_3221	COG2608	mercury ion transmembrane transporter activity
C663_3222	COG1937	Protein conserved in bacteria
C663_3223	COG0673	inositol 2-dehydrogenase activity
C663_3228	COG2076	Multidrug Resistance protein
C663_3229	COG1309	transcriptional regulator
C663_3230	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3231	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C663_3232	COG0557	exoribonuclease II activity
C663_3233	COG1647	Serine aminopeptidase, S33
C663_3234	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C663_3235	COG0596	Alpha beta hydrolase
C663_3236	COG1476	TRANSCRIPTIONal
C663_3237	COG1396	sequence-specific DNA binding
C663_3238	COG1396	sequence-specific DNA binding
C663_3239	COG1733	regulation of RNA biosynthetic process
C663_3244	COG1174	glycine betaine transport
C663_3245	COG1732	Glycine betaine
C663_3246	COG1174	glycine betaine transport
C663_3247	COG1125	glycine betaine transport
C663_3247	COG0517	IMP dehydrogenase activity
C663_3248	COG1510	regulation of RNA biosynthetic process
C663_3249	COG1174	glycine betaine transport
C663_3250	COG1732	Glycine betaine
C663_3251	COG1174	glycine betaine transport
C663_3252	COG0517	IMP dehydrogenase activity
C663_3252	COG1125	glycine betaine transport
C663_3254	COG2095	MarC family integral membrane protein
C663_3256	COG3064	Membrane
C663_3257	COG4640	response to antibiotic
C663_3258	COG0456	acetyltransferase
C663_3261	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C663_3270	COG0148	phosphopyruvate hydratase activity
C663_3271	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C663_3272	COG0149	triose-phosphate isomerase activity
C663_3273	COG0126	phosphoglycerate kinase activity
C663_3274	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C663_3275	COG2390	Transcriptional regulator
C663_3276	COG2814	Major facilitator Superfamily
C663_3277	COG1609	Transcriptional regulator
C663_3278	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C663_3279	COG0583	DNA-binding transcription factor activity
C663_3280	COG0697	spore germination
C663_3281	COG1113	amino acid transport
C663_3282	COG3858	chitin binding
C663_3283	COG1556	Lactate utilization protein
C663_3284	COG1139	Iron-sulfur cluster binding protein
C663_3285	COG0247	lactate metabolic process
C663_3286	COG2197	response regulator
C663_3287	COG4585	Histidine kinase
C663_3288	COG0842	Transport permease protein
C663_3289	COG1131	(ABC) transporter
C663_3290	COG0596	Alpha beta hydrolase
C663_3291	COG2208	phosphoserine phosphatase activity
C663_3292	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C663_3293	COG1874	Beta-galactosidase
C663_3294	COG3833	ABC-type maltose transport systems, permease component
C663_3295	COG1175	transmembrane transport
C663_3296	COG2182	Extracellular solute-binding protein
C663_3297	COG1609	Transcriptional regulator
C663_3299	COG2186	Transcriptional regulator
C663_3300	COG1620	l-lactate permease
C663_3301	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C663_3303	COG5039	Polysaccharide pyruvyl transferase
C663_3304	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C663_3305	COG0110	maltose O-acetyltransferase activity
C663_3306	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C663_3307	COG2244	polysaccharide biosynthetic process
C663_3308	COG1216	Glycosyl transferase, family 2
C663_3309	COG5039	Polysaccharide pyruvyl transferase
C663_3310	COG1216	Glycosyl transferase, family 2
C663_3312	COG0438	transferase activity, transferring glycosyl groups
C663_3313	COG1215	transferase activity, transferring glycosyl groups
C663_3314	COG0438	transferase activity, transferring glycosyl groups
C663_3315	COG1086	Polysaccharide biosynthesis protein
C663_3316	COG0489	protein tyrosine kinase activity
C663_3317	COG3944	biosynthesis protein
C663_3318	COG1396	sequence-specific DNA binding
C663_3319	COG2272	Belongs to the type-B carboxylesterase lipase family
C663_3321	COG3479	Phenolic acid decarboxylase
C663_3323	COG1794	racemase activity, acting on amino acids and derivatives
C663_3324	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C663_3325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C663_3329	COG1621	beta-fructofuranosidase activity
C663_3331	COG0531	amino acid
C663_3332	COG1309	transcriptional regulator
C663_3333	COG2076	Multidrug Resistance protein
C663_3334	COG2076	Multidrug Resistance protein
C663_3340	COG0740	serine-type endopeptidase activity
C663_3341	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C663_3342	COG0366	Alpha amylase catalytic
C663_3343	COG1554	hydrolase, family 65, central catalytic
C663_3345	COG3833	ABC-type maltose transport systems, permease component
C663_3346	COG1175	transmembrane transport
C663_3347	COG1175	transmembrane transport
C663_3348	COG2182	Extracellular solute-binding protein
C663_3349	COG0366	Alpha amylase catalytic
C663_3350	COG1609	Transcriptional regulator
C663_3351	COG1611	Belongs to the LOG family
C663_3352	COG1694	Mazg nucleotide pyrophosphohydrolase
C663_3353	COG0659	secondary active sulfate transmembrane transporter activity
C663_3354	COG0288	reversible hydration of carbon dioxide
C663_3355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C663_3356	COG0577	efflux transmembrane transporter activity
C663_3357	COG1136	(ABC) transporter
C663_3358	COG5002	protein histidine kinase activity
C663_3359	COG0745	RESPONSE REGULATOR receiver
C663_3361	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C663_3362	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C663_3363	COG1481	regulation of sporulation
C663_3364	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C663_3365	COG1660	Displays ATPase and GTPase activities
C663_3366	COG1051	belongs to the nudix hydrolase family
C663_3367	COG0492	ferredoxin-NADP+ reductase activity
C663_3368	COG0791	NLP P60 protein
C663_3368	COG3883	PFAM NLP P60 protein
C663_3369	COG0457	Tetratricopeptide repeat
C663_3370	COG1132	(ABC) transporter
C663_3374	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C663_3374	COG0140	phosphoribosyl-ATP diphosphatase activity
C663_3376	COG0107	imidazoleglycerol-phosphate synthase activity
C663_3377	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C663_3378	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C663_3380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C663_3381	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C663_3382	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C663_3383	COG4990	cell redox homeostasis
C663_3384	COG5297	Belongs to the glycosyl hydrolase family 6
C663_3385	COG0110	maltose O-acetyltransferase activity
C663_3387	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C663_3388	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C663_3389	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C663_3390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C663_3391	COG0363	glucosamine-6-phosphate deaminase activity
C663_3393	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C663_3394	COG1950	PFAM Membrane protein of
C663_3395	COG1983	PspC domain protein
C663_3396	COG3595	metallopeptidase activity
C663_3399	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C663_3401	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C663_3402	COG0556	nucleotide-excision repair
C663_3403	COG4897	Protein conserved in bacteria
C663_3404	COG3848	Pyruvate phosphate dikinase
C663_3404	COG0574	Belongs to the PEP-utilizing enzyme family
C663_3405	COG1309	transcriptional regulator
C663_3406	COG2814	Major facilitator Superfamily
C663_3407	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C663_3409	COG0793	Belongs to the peptidase S41A family
C663_3409	COG3409	Peptidoglycan-binding domain 1 protein
C663_3410	COG2177	Part of the ABC transporter FtsEX involved in
C663_3411	COG2884	Cell division ATP-binding protein ftsE
C663_3412	COG2010	Cytochrome c
C663_3413	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C663_3414	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C663_3415	COG0653	protein targeting
C663_3416	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C663_3419	COG1516	flagellar protein fliS
C663_3420	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C663_3421	COG1334	flagellar protein FlaG
C663_3423	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C663_3424	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C663_3426	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C663_3427	COG4786	Flagellar basal body rod
C663_3427	COG1256	bacterial-type flagellum assembly
C663_3428	COG3418	PFAM FlgN family protein
C663_3429	COG2747	anti-sigma28 factor FlgM
C663_3431	COG1040	competence protein
C663_3433	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C663_3434	COG1307	EDD domain protein, DegV family
C663_3435	COG2197	response regulator
C663_3436	COG1739	Uncharacterized protein family UPF0029
C663_3437	COG1316	TRANSCRIPTIONal
C663_3438	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C663_3439	COG0438	transferase activity, transferring glycosyl groups
C663_3440	COG1215	transferase activity, transferring glycosyl groups
C663_3441	COG3206	protein involved in exopolysaccharide biosynthesis
C663_3442	COG3307	-O-antigen
C663_3443	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C663_3444	COG0297	glycogen (starch) synthase activity
C663_3444	COG0438	transferase activity, transferring glycosyl groups
C663_3445	COG2244	polysaccharide biosynthetic process
C663_3448	COG2247	cell wall binding repeat
C663_3448	COG0860	N-Acetylmuramoyl-L-alanine amidase
C663_3449	COG2247	cell wall binding repeat
C663_3449	COG2385	sporulation resulting in formation of a cellular spore
C663_3452	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C663_3458	COG1134	teichoic acid transport
C663_3459	COG1682	transport, permease protein
C663_3463	COG0463	Glycosyl transferase, family 2
C663_3472	COG4193	domain, Protein
C663_3473	COG1482	cell wall glycoprotein biosynthetic process
C663_3474	COG0697	spore germination
C663_3475	COG0814	amino acid
C663_3477	COG2814	Major facilitator Superfamily
C663_3478	COG1316	TRANSCRIPTIONal
C663_3479	COG0561	phosphatase activity
C663_3480	COG0791	NLP P60 protein
C663_3482	COG2843	Capsule synthesis protein
C663_3484	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C663_3486	COG1609	Transcriptional regulator
C663_3487	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C663_3488	COG1869	D-ribose catabolic process
C663_3489	COG1129	ABC transporter
C663_3491	COG1879	ABC-type sugar transport system periplasmic component
C663_3492	COG3103	Sh3 type 3 domain protein
C663_3494	COG2249	NAD(P)H dehydrogenase (quinone) activity
C663_3495	COG3527	Alpha-acetolactate decarboxylase
C663_3496	COG0028	Belongs to the TPP enzyme family
C663_3497	COG0583	DNA-binding transcription factor activity
C663_3498	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C663_3501	COG5337	Spore coat protein CotH
C663_3503	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C663_3505	COG0405	Gamma-glutamyltransferase
C663_3506	COG1522	sequence-specific DNA binding
C663_3507	COG2059	Chromate
C663_3508	COG2059	Chromate
C663_3510	COG5444	nuclease activity
C663_3513	COG3878	Protein conserved in bacteria
C663_3514	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C663_3515	COG4464	protein tyrosine phosphatase activity
C663_3516	COG0489	protein tyrosine kinase activity
C663_3517	COG3944	biosynthesis protein
C663_3519	COG4715	Zinc finger, swim domain protein
C663_3520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C663_3521	COG0561	phosphatase activity
C663_3522	COG1349	DNA-binding transcription factor activity
C663_3523	COG0629	single-stranded DNA binding
C663_3529	COG3279	Response regulator of the LytR AlgR family
C663_3530	COG2972	Histidine kinase
C663_3530	COG0745	RESPONSE REGULATOR receiver
C663_3531	COG1970	mechanosensitive ion channel activity
C663_3532	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C663_3533	COG0457	Tetratricopeptide repeat
C663_3534	COG4786	Flagellar basal body rod
C663_3535	COG4786	Flagellar basal body rod
C663_3536	COG1077	Cell shape determining protein MreB Mrl
C663_3537	COG1609	Transcriptional regulator
C663_3538	COG1846	Transcriptional regulator
C663_3539	COG2814	Major facilitator Superfamily
C663_3540	COG3420	alginic acid biosynthetic process
C663_3541	COG1953	Uracil, thiamine, allantoin
C663_3542	COG0477	Major facilitator Superfamily
C663_3543	COG1335	isochorismatase
C663_3545	COG0004	ammonium transporteR
C663_3546	COG0347	Belongs to the P(II) protein family
C663_3547	COG0671	phosphoesterase, PA-phosphatase related
C663_3549	COG0739	heme binding
C663_3550	COG1247	-acetyltransferase
C663_3554	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C663_3556	COG2910	NAD(P)H-binding
C663_3557	COG1959	2 iron, 2 sulfur cluster binding
C663_3558	COG0804	urea catabolic process
C663_3559	COG0832	Belongs to the urease beta subunit family
C663_3560	COG0831	urea catabolic process
C663_3563	COG3237	CsbD-like
C663_3564	COG1994	Peptidase M50
C663_3565	COG0457	Tetratricopeptide repeat
C663_3566	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C663_3567	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C663_3569	COG2304	oxidoreductase activity
C663_3572	COG2304	oxidoreductase activity
C663_3574	COG2385	sporulation resulting in formation of a cellular spore
C663_3575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C663_3577	COG4836	Membrane
C663_3579	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C663_3580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C663_3581	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C663_3582	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C663_3583	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C663_3584	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C663_3585	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C663_3588	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C663_3589	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C663_3590	COG4475	Protein of unknown function (DUF436)
C663_3591	COG0698	ribose 5-phosphate isomerase
C663_3592	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C663_3593	COG1971	Probably functions as a manganese efflux pump
C663_3594	COG0009	L-threonylcarbamoyladenylate synthase
C663_3595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C663_3599	COG2890	protein-(glutamine-N5) methyltransferase activity
C663_3600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C663_3601	COG0346	lactoylglutathione lyase activity
C663_3602	COG0789	Transcriptional regulator
C663_3603	COG0679	Auxin Efflux Carrier
C663_3604	COG0281	malic enzyme
C663_3605	COG1435	thymidine kinase activity
C663_3606	COG0254	rRNA binding
C663_3607	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C663_3609	COG1494	fructose-1,6-bisphosphatase
C663_3610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C663_3611	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C663_3612	COG0191	fructose-bisphosphate aldolase activity
C663_3613	COG2204	response regulator
C663_3614	COG4821	SIS domain
C663_3615	COG0504	CTP synthase activity
C663_3616	COG3343	RNA polymerase activity
C663_3617	COG1960	acyl-CoA dehydrogenase activity
C663_3618	COG0247	lactate metabolic process
C663_3618	COG2181	nitrate reductase activity
C663_3619	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C663_3620	COG4294	response to UV
C663_3622	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C663_3623	COG1132	(ABC) transporter
C663_3624	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C663_3626	COG2181	nitrate reductase activity
C663_3627	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C663_3628	COG1140	nitrate reductase beta subunit
C663_3629	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C663_3630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C663_3632	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C663_3633	COG2223	nitrite transmembrane transporter activity
C663_3634	COG0018	arginyl-trna synthetase
C663_3635	COG4506	Protein conserved in bacteria
C663_3637	COG0535	radical SAM domain protein
C663_3639	COG1131	(ABC) transporter
C663_3640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C663_3641	COG0612	Peptidase, M16
C663_3642	COG0612	Peptidase, M16
C663_3644	COG3391	amine dehydrogenase activity
C663_3645	COG3391	amine dehydrogenase activity
C663_3647	COG0457	Tetratricopeptide repeat
C663_3652	COG1131	(ABC) transporter
C663_3654	COG0010	Belongs to the arginase family
C663_3655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C663_3656	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C663_3658	COG1994	Peptidase M50
C663_3659	COG1942	4-Oxalocrotonate Tautomerase
C663_3660	COG1846	Transcriptional regulator
C663_3661	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C663_3662	COG0477	Major facilitator Superfamily
C663_3663	COG1959	2 iron, 2 sulfur cluster binding
C663_3664	COG3465	dGTPase activity
C663_3665	COG1078	dGTPase activity
C663_3666	COG4844	belongs to the
C663_3668	COG0697	spore germination
C663_3669	COG0095	Lipoate-protein ligase
C663_3670	COG0583	DNA-binding transcription factor activity
C663_3671	COG0280	phosphate acetyltransferase
C663_3673	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3674	COG0436	Aminotransferase
C663_3675	COG2814	Major facilitator Superfamily
C663_3676	COG0151	Belongs to the GarS family
C663_3677	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3678	COG1917	Cupin 2, conserved barrel domain protein
C663_3679	COG0077	Prephenate dehydratase
C663_3681	COG2814	Major facilitator Superfamily
C663_3682	COG0833	amino acid
C663_3683	COG4187	Peptidase family M20/M25/M40
C663_3684	COG1012	belongs to the aldehyde dehydrogenase family
C663_3685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C663_3688	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C663_3689	COG1091	dTDP-4-dehydrorhamnose reductase activity
C663_3690	COG1088	dTDP-glucose 4,6-dehydratase activity
C663_3691	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C663_3692	COG3980	spore coat polysaccharide biosynthesis protein
C663_3693	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C663_3694	COG2089	acid synthase
C663_3695	COG0456	acetyltransferase
C663_3696	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C663_3697	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C663_3699	COG0463	Glycosyl transferase, family 2
C663_3701	COG2363	Small membrane protein
C663_3702	COG2233	PERMEase
C663_3704	COG1012	belongs to the aldehyde dehydrogenase family
C663_3705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C663_3706	COG1216	Glycosyl transferase, family 2
C663_3709	COG1621	beta-fructofuranosidase activity
C663_3710	COG1263	PTS System
C663_3710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_3711	COG2116	formate transmembrane transporter activity
C663_3712	COG2116	formate transmembrane transporter activity
C663_3713	COG3711	transcriptional antiterminator
C663_3715	COG1404	Belongs to the peptidase S8 family
C663_3716	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C663_3717	COG0778	Nitroreductase
C663_3718	COG0772	Belongs to the SEDS family
C663_3720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C663_3721	COG1845	cytochrome c oxidase, subunit III
C663_3722	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C663_3723	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C663_3725	COG2261	transglycosylase associated protein
C663_3727	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C663_3728	COG2246	polysaccharide biosynthetic process
C663_3729	COG1309	transcriptional regulator
C663_3731	COG3162	membrane
C663_3732	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C663_3733	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C663_3734	COG2837	iron assimilation
C663_3735	COG2822	iron ion transport
C663_3736	COG0672	)-iron permease
C663_3737	COG0352	thiamine-phosphate diphosphorylase activity
C663_3738	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C663_3739	COG0583	DNA-binding transcription factor activity
C663_3740	COG1380	Effector of murein hydrolase LrgA
C663_3741	COG1346	cytolysis
C663_3742	COG2814	Major facilitator Superfamily
C663_3743	COG4895	conserved protein (DUF2196)
C663_3744	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C663_3745	COG0346	lactoylglutathione lyase activity
C663_3748	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C663_3750	COG1404	Belongs to the peptidase S8 family
C663_3752	COG1263	PTS System
C663_3752	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_3753	COG3711	transcriptional antiterminator
C663_3754	COG1442	glycosyl transferase family 8
C663_3755	COG5522	Integral membrane protein (intg_mem_TP0381)
C663_3756	COG1846	Transcriptional regulator
C663_3758	COG2234	aminopeptidase activity
C663_3759	COG2357	RelA SpoT domain protein
C663_3760	COG1575	Belongs to the MenA family. Type 1 subfamily
C663_3763	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C663_3764	COG1696	Membrane protein involved in D-alanine export
C663_3765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C663_3766	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C663_3767	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C663_3768	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C663_3769	COG1486	melibiose metabolic process
C663_3770	COG1447	Phosphotransferase system cellobiose-specific component IIA
C663_3771	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C663_3772	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C663_3773	COG3711	transcriptional antiterminator
C663_3773	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C663_3775	COG2094	Belongs to the DNA glycosylase MPG family
C663_3776	COG0753	catalase activity
C663_3777	COG2814	Major facilitator Superfamily
C663_3778	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C663_3784	COG1595	DNA-templated transcription, initiation
C663_3785	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C663_3786	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C663_3787	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C663_3788	COG4988	ABC transporter
C663_3789	COG1294	oxidase, subunit
C663_3790	COG1271	oxidase subunit
C663_3792	COG3493	citrate carrier protein
C663_3793	COG0501	Belongs to the peptidase M48B family
C663_3795	COG0726	polysaccharide deacetylase
C663_3797	COG3842	ATPase activity
C663_3798	COG2508	Transcriptional regulator
C663_3799	COG1012	belongs to the aldehyde dehydrogenase family
C663_3800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C663_3802	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C663_3803	COG1881	PFAM PEBP family protein
C663_3804	COG0583	DNA-binding transcription factor activity
C663_3807	COG2197	response regulator
C663_3808	COG2195	Cleaves the N-terminal amino acid of tripeptides
C663_3811	COG4894	glucomannan catabolic process
C663_3812	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C663_3813	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C663_3814	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C663_3816	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C663_3817	COG2610	gluconate transmembrane transporter activity
C663_3818	COG0500	methyltransferase
C663_3819	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C663_3822	COG0693	protein deglycase activity
C663_3822	COG0753	catalase activity
C663_3823	COG2851	Citrate transporter
C663_3824	COG2273	Hydrolase Family 16
C663_3825	COG3711	transcriptional antiterminator
C663_3828	COG2270	Major facilitator Superfamily
C663_3829	COG0513	Belongs to the DEAD box helicase family
C663_3830	COG3401	FG-GAP repeat protein
C663_3830	COG2755	lipolytic protein G-D-S-L family
C663_3835	COG0697	spore germination
C663_3836	COG0589	response to stress
C663_3837	COG2723	6-phospho-beta-galactosidase activity
C663_3838	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C663_3838	COG1263	PTS System
C663_3838	COG2190	(PTS) system
C663_3846	COG5444	nuclease activity
C663_3851	COG0494	nUDIX hydrolase
C663_3852	COG3507	Belongs to the glycosyl hydrolase 43 family
C663_3855	COG2986	histidine ammonia-lyase
C663_3856	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C663_3857	COG1228	amidohydrolase
C663_3858	COG0010	Belongs to the arginase family
C663_3859	COG0833	amino acid
C663_3860	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C663_3861	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C663_3862	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C663_3863	COG2390	Transcriptional regulator
C663_3865	COG3192	ethanolamine utilization protein
C663_3866	COG2079	MmgE PrpD family protein
C663_3868	COG1126	abc transporter atp-binding protein
C663_3869	COG0765	amino acid transport
C663_3870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C663_3873	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C663_3874	COG0561	phosphatase activity
C663_3880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C663_3882	COG0577	efflux transmembrane transporter activity
C663_3883	COG1136	(ABC) transporter
C663_3884	COG2205	protein histidine kinase activity
C663_3885	COG0745	RESPONSE REGULATOR receiver
C663_3886	COG0191	fructose-bisphosphate aldolase activity
C663_3887	COG1082	Xylose isomerase domain protein TIM barrel
C663_3888	COG1082	Xylose isomerase domain protein TIM barrel
C663_3889	COG0673	inositol 2-dehydrogenase activity
C663_3890	COG2814	Major facilitator Superfamily
C663_3891	COG1082	Xylose isomerase domain protein TIM barrel
C663_3892	COG3962	Belongs to the TPP enzyme family
C663_3893	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C663_3895	COG1012	belongs to the aldehyde dehydrogenase family
C663_3896	COG1349	DNA-binding transcription factor activity
C663_3897	COG1349	DNA-binding transcription factor activity
C663_3898	COG0667	Aldo Keto reductase
C663_3901	COG2814	Major facilitator Superfamily
C663_3902	COG0326	Molecular chaperone. Has ATPase activity
C663_3904	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3905	COG1309	transcriptional regulator
C663_3906	COG1012	belongs to the aldehyde dehydrogenase family
C663_3908	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C663_3911	COG1714	RDD family
C663_3912	COG2311	Membrane
C663_3913	COG1917	Cupin 2, conserved barrel domain protein
C663_3914	COG1309	transcriptional regulator
C663_3915	COG1028	Short-chain dehydrogenase reductase Sdr
C663_3916	COG1846	Transcriptional regulator
C663_3918	COG1346	cytolysis
C663_3919	COG5039	Polysaccharide pyruvyl transferase
C663_3920	COG1929	Belongs to the glycerate kinase type-1 family
C663_3921	COG1802	Transcriptional regulator
C663_3922	COG1070	Carbohydrate kinase
C663_3923	COG2610	gluconate transmembrane transporter activity
C663_3924	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C663_3925	COG0450	alkyl hydroperoxide reductase
C663_3926	COG3634	alkyl hydroperoxide reductase activity
C663_3928	COG2723	6-phospho-beta-galactosidase activity
C663_3929	COG2190	(PTS) system
C663_3930	COG2188	Transcriptional regulator
C663_3932	COG1131	(ABC) transporter
C663_3933	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C663_3935	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C663_3937	COG0210	DNA helicase
C663_3938	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C663_3941	COG1063	alcohol dehydrogenase
C663_3945	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C663_3946	COG0456	acetyltransferase
C663_3949	COG0010	Belongs to the arginase family
C663_3950	COG0833	amino acid
C663_3951	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C663_3952	COG3829	transcription factor binding
C663_3953	COG5002	protein histidine kinase activity
C663_3954	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C663_3955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C663_3956	COG4853	Protein conserved in bacteria
C663_3957	COG4863	YycH protein
C663_3958	COG5002	protein histidine kinase activity
C663_3959	COG0745	RESPONSE REGULATOR receiver
C663_3961	COG0346	lactoylglutathione lyase activity
C663_3963	COG0305	Participates in initiation and elongation during chromosome replication
C663_3966	COG3093	addiction module antidote protein HigA
C663_3967	COG2807	transmembrane transport
C663_3968	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C663_3969	COG0359	binds to the 23S rRNA
C663_3970	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C663_3971	COG4241	membrane
C663_3974	COG5577	PFAM Coat F domain
C663_3975	COG1733	regulation of RNA biosynthetic process
C663_3976	COG1227	inorganic diphosphatase activity
C663_3979	COG2271	Major facilitator Superfamily
C663_3980	COG0789	Transcriptional regulator
C663_3980	COG4978	Transcriptional regulator
C663_3982	COG4319	ketosteroid isomerase
C663_3983	COG1357	PFAM Pentapeptide repeats (8 copies)
C663_3984	COG2814	Major facilitator Superfamily
C663_3985	COG0583	DNA-binding transcription factor activity
C663_3986	COG2153	protein acetylation
C663_3988	COG0583	DNA-binding transcription factor activity
C663_3992	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C663_3993	COG1846	Transcriptional regulator
C663_3994	COG2153	protein acetylation
C663_3995	COG2364	Membrane
C663_3996	COG0456	acetyltransferase
C663_3998	COG2315	Protein conserved in bacteria
C663_3999	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C663_4000	COG1331	Highly conserved protein containing a thioredoxin domain
C663_4001	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C663_4002	COG0798	PFAM Bile acid sodium symporter
C663_4003	COG0346	lactoylglutathione lyase activity
C663_4004	COG0640	Transcriptional regulator
C663_4008	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C663_4011	COG1266	CAAX protease self-immunity
C663_4013	COG2814	Major facilitator Superfamily
C663_4013	COG0477	Major facilitator Superfamily
C663_4014	COG0110	maltose O-acetyltransferase activity
C663_4015	COG0346	lactoylglutathione lyase activity
C663_4016	COG1609	Transcriptional regulator
C663_4017	COG0708	Exodeoxyribonuclease III
C663_4019	COG0360	Binds together with S18 to 16S ribosomal RNA
C663_4020	COG0012	GTP binding
C663_4021	COG0243	molybdopterin cofactor binding
C663_4022	COG4481	Protein conserved in bacteria
C663_4023	COG3949	Membrane
C663_4025	COG1475	DNA binding
C663_4026	COG1192	Involved in chromosome partitioning
C663_4028	COG1475	DNA binding
C663_4029	COG0357	Ribosomal RNA small subunit methyltransferase G
C663_4030	COG0445	tRNA wobble uridine modification
C663_4031	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C663_4032	COG1847	R3H domain protein
C663_4033	COG0706	membrane insertase activity
C663_4034	COG0594	ribonuclease P activity