locus-tag	class	description
GFX43_000005	COG0726	polysaccharide deacetylase
GFX43_000010	COG2194	sulfuric ester hydrolase activity
GFX43_000020	COG0489	protein tyrosine kinase activity
GFX43_000025	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFX43_000035	COG2226	methyltransferase
GFX43_000040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFX43_000045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFX43_000050	COG0101	tRNA pseudouridine synthase activity
GFX43_000055	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GFX43_000060	COG1122	ATPase activity
GFX43_000065	COG1122	ATPase activity
GFX43_000070	COG0203	ribosomal protein L17
GFX43_000075	COG0202	RNA polymerase activity
GFX43_000080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFX43_000085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFX43_000090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFX43_000095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFX43_000100	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GFX43_000105	COG0024	Methionine aminopeptidase
GFX43_000110	COG0563	adenylate kinase activity
GFX43_000115	COG0201	protein transport
GFX43_000120	COG0200	Binds to the 23S rRNA
GFX43_000125	COG1841	ribosomal large subunit assembly
GFX43_000130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFX43_000135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GFX43_000140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFX43_000145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFX43_000155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFX43_000165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFX43_000170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFX43_000175	COG0255	Belongs to the universal ribosomal protein uL29 family
GFX43_000180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFX43_000185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFX43_000190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFX43_000195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFX43_000200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFX43_000205	COG0089	rRNA binding
GFX43_000210	COG0088	Forms part of the polypeptide exit tunnel
GFX43_000215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFX43_000220	COG0051	transcription antitermination factor activity, RNA binding
GFX43_000225	COG0596	Alpha beta hydrolase
GFX43_000230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFX43_000235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFX43_000240	COG0049	tRNA binding
GFX43_000245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFX43_000250	COG1358	cellular component organization or biogenesis
GFX43_000255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFX43_000260	COG0085	RNA polymerase activity
GFX43_000265	COG2813	Specifically methylates the guanine in position
GFX43_000270	COG0222	ribosome binding
GFX43_000275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFX43_000280	COG0081	regulation of translation
GFX43_000285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFX43_000290	COG0250	Participates in transcription elongation, termination and antitermination
GFX43_000295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFX43_000300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFX43_000305	COG1595	DNA-templated transcription, initiation
GFX43_000310	COG3688	RNA-binding protein containing a PIN domain
GFX43_000315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFX43_000320	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GFX43_000325	COG0215	cysteine-tRNA ligase activity
GFX43_000330	COG1045	serine acetyltransferase
GFX43_000335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFX43_000340	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GFX43_000345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GFX43_000350	COG4956	integral membrane protein (PIN domain superfamily)
GFX43_000355	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GFX43_000360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GFX43_000365	COG0542	response to heat
GFX43_000370	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GFX43_000375	COG3880	PFAM UvrB UvrC protein
GFX43_000380	COG4463	regulation of RNA biosynthetic process
GFX43_000460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFX43_000465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFX43_000470	COG1396	sequence-specific DNA binding
GFX43_000475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GFX43_000480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GFX43_000485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFX43_000490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFX43_000495	COG0512	Glutamine amidotransferase of anthranilate synthase
GFX43_000500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFX43_000505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFX43_000510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFX43_000515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GFX43_000520	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GFX43_000525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFX43_000535	COG0037	tRNA processing
GFX43_000540	COG0515	serine threonine protein kinase
GFX43_000545	COG2304	oxidoreductase activity
GFX43_000550	COG2208	phosphoserine phosphatase activity
GFX43_000565	COG1098	S1 RNA binding domain
GFX43_000570	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GFX43_000585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GFX43_000590	COG3956	TIGRFAM MazG family protein
GFX43_000595	COG2244	polysaccharide biosynthetic process
GFX43_000600	COG2002	toxin-antitoxin pair type II binding
GFX43_000605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFX43_000615	COG0193	aminoacyl-tRNA hydrolase activity
GFX43_000620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GFX43_000625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFX43_000630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFX43_000635	COG2088	sporulation resulting in formation of a cellular spore
GFX43_000640	COG0251	oxidation-reduction process
GFX43_000645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFX43_000650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GFX43_000660	COG4466	Protein conserved in bacteria
GFX43_000670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFX43_000675	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GFX43_000680	COG3583	domain protein
GFX43_000680	COG3584	3D domain protein
GFX43_000685	COG0084	hydrolase, TatD family'
GFX43_000690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFX43_000690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFX43_000695	COG2002	toxin-antitoxin pair type II binding
GFX43_000700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFX43_000705	COG2827	Endonuclease containing a URI domain
GFX43_000710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GFX43_000715	COG4467	Involved in initiation control of chromosome replication
GFX43_000720	COG1774	PSP1 C-terminal conserved region
GFX43_000725	COG0470	DNA polymerase III
GFX43_000730	COG1728	Protein conserved in bacteria
GFX43_000735	COG3870	Protein conserved in bacteria
GFX43_000740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFX43_000745	COG1982	Orn Lys Arg decarboxylase major
GFX43_000750	COG3853	Toxic anion resistance protein (TelA)
GFX43_000755	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GFX43_000800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFX43_000805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GFX43_000810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFX43_000820	COG0590	tRNA wobble adenosine to inosine editing
GFX43_000825	COG1335	isochorismatase
GFX43_000830	COG1388	LysM domain
GFX43_000830	COG3858	chitin binding
GFX43_000835	COG1428	Deoxynucleoside kinase
GFX43_000840	COG1428	Deoxynucleoside kinase
GFX43_000850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFX43_000855	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GFX43_000860	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GFX43_000865	COG1686	Belongs to the peptidase S11 family
GFX43_000870	COG0517	IMP dehydrogenase activity
GFX43_000870	COG0516	GMP reductase activity
GFX43_000905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFX43_000910	COG0187	DNA topoisomerase II activity
GFX43_000920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFX43_000925	COG2501	S4 domain
GFX43_000930	COG0592	DNA-directed DNA polymerase activity
GFX43_000935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFX43_000940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GFX43_000945	COG0594	ribonuclease P activity
GFX43_000950	COG0706	membrane insertase activity
GFX43_000955	COG1847	R3H domain protein
GFX43_000960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GFX43_000965	COG0445	tRNA wobble uridine modification
GFX43_000970	COG0357	Ribosomal RNA small subunit methyltransferase G
GFX43_000975	COG1475	DNA binding
GFX43_000985	COG1192	Involved in chromosome partitioning
GFX43_000990	COG1475	DNA binding
GFX43_001000	COG3949	Membrane
GFX43_001005	COG4481	Protein conserved in bacteria
GFX43_001010	COG0243	molybdopterin cofactor binding
GFX43_001015	COG0012	GTP binding
GFX43_001020	COG0360	Binds together with S18 to 16S ribosomal RNA
GFX43_001025	COG0629	single-stranded DNA binding
GFX43_001030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GFX43_001035	COG0708	Exodeoxyribonuclease III
GFX43_001040	COG1609	Transcriptional regulator
GFX43_001045	COG0346	lactoylglutathione lyase activity
GFX43_001050	COG0110	maltose O-acetyltransferase activity
GFX43_001055	COG0477	Major facilitator Superfamily
GFX43_001055	COG2814	Major facilitator Superfamily
GFX43_001060	COG1266	CAAX protease self-immunity
GFX43_001065	COG1331	Highly conserved protein containing a thioredoxin domain
GFX43_001075	COG0863	Belongs to the N(4) N(6)-methyltransferase family
GFX43_001080	COG1331	Highly conserved protein containing a thioredoxin domain
GFX43_001085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFX43_001095	COG0640	Transcriptional regulator
GFX43_001100	COG0346	lactoylglutathione lyase activity
GFX43_001105	COG0798	PFAM Bile acid sodium symporter
GFX43_001110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFX43_001115	COG1331	Highly conserved protein containing a thioredoxin domain
GFX43_001120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFX43_001125	COG2315	Protein conserved in bacteria
GFX43_001130	COG0456	acetyltransferase
GFX43_001135	COG2364	Membrane
GFX43_001140	COG2153	protein acetylation
GFX43_001145	COG1846	Transcriptional regulator
GFX43_001150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFX43_001165	COG0583	DNA-binding transcription factor activity
GFX43_001175	COG2153	protein acetylation
GFX43_001180	COG0583	DNA-binding transcription factor activity
GFX43_001185	COG2814	Major facilitator Superfamily
GFX43_001190	COG1357	PFAM Pentapeptide repeats (8 copies)
GFX43_001195	COG4319	ketosteroid isomerase
GFX43_001205	COG0789	Transcriptional regulator
GFX43_001205	COG4978	Transcriptional regulator
GFX43_001210	COG2271	Major facilitator Superfamily
GFX43_001220	COG1227	inorganic diphosphatase activity
GFX43_001225	COG1733	regulation of RNA biosynthetic process
GFX43_001230	COG5577	PFAM Coat F domain
GFX43_001240	COG4241	membrane
GFX43_001245	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GFX43_001250	COG0359	binds to the 23S rRNA
GFX43_001255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GFX43_001260	COG2807	transmembrane transport
GFX43_001265	COG3093	addiction module antidote protein HigA
GFX43_001280	COG0305	Participates in initiation and elongation during chromosome replication
GFX43_001285	COG0346	lactoylglutathione lyase activity
GFX43_001315	COG0745	RESPONSE REGULATOR receiver
GFX43_001320	COG5002	protein histidine kinase activity
GFX43_001325	COG4863	YycH protein
GFX43_001330	COG4853	Protein conserved in bacteria
GFX43_001335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFX43_001340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFX43_001355	COG3829	transcription factor binding
GFX43_001360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFX43_001365	COG0833	amino acid
GFX43_001370	COG0010	Belongs to the arginase family
GFX43_001380	COG0457	Tetratricopeptide repeat
GFX43_001385	COG0456	acetyltransferase
GFX43_001390	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GFX43_001410	COG1063	alcohol dehydrogenase
GFX43_001425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GFX43_001440	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GFX43_001450	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GFX43_001455	COG1131	(ABC) transporter
GFX43_001470	COG2188	Transcriptional regulator
GFX43_001475	COG2190	(PTS) system
GFX43_001480	COG2723	6-phospho-beta-galactosidase activity
GFX43_001490	COG3634	alkyl hydroperoxide reductase activity
GFX43_001495	COG0450	alkyl hydroperoxide reductase
GFX43_001500	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GFX43_001505	COG2610	gluconate transmembrane transporter activity
GFX43_001510	COG1070	Carbohydrate kinase
GFX43_001515	COG1802	Transcriptional regulator
GFX43_001520	COG1929	Belongs to the glycerate kinase type-1 family
GFX43_001525	COG5039	Polysaccharide pyruvyl transferase
GFX43_001530	COG1346	cytolysis
GFX43_001535	COG1380	Effector of murein hydrolase LrgA
GFX43_001540	COG1846	Transcriptional regulator
GFX43_001545	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_001550	COG1309	transcriptional regulator
GFX43_001555	COG1917	Cupin 2, conserved barrel domain protein
GFX43_001560	COG2311	Membrane
GFX43_001565	COG1714	RDD family
GFX43_001575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GFX43_001580	COG1714	RDD family
GFX43_001585	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_001590	COG1309	transcriptional regulator
GFX43_001595	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_001605	COG0326	Molecular chaperone. Has ATPase activity
GFX43_001610	COG2814	Major facilitator Superfamily
GFX43_001625	COG0667	Aldo Keto reductase
GFX43_001630	COG1349	DNA-binding transcription factor activity
GFX43_001635	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_001645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFX43_001650	COG3962	Belongs to the TPP enzyme family
GFX43_001655	COG1082	Xylose isomerase domain protein TIM barrel
GFX43_001660	COG2814	Major facilitator Superfamily
GFX43_001665	COG0673	inositol 2-dehydrogenase activity
GFX43_001670	COG1082	Xylose isomerase domain protein TIM barrel
GFX43_001675	COG1082	Xylose isomerase domain protein TIM barrel
GFX43_001680	COG0191	fructose-bisphosphate aldolase activity
GFX43_001685	COG0745	RESPONSE REGULATOR receiver
GFX43_001690	COG2205	protein histidine kinase activity
GFX43_001695	COG1136	(ABC) transporter
GFX43_001700	COG0577	efflux transmembrane transporter activity
GFX43_001705	COG5294	Protein conserved in bacteria
GFX43_001710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFX43_001740	COG0561	phosphatase activity
GFX43_001745	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GFX43_001760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFX43_001765	COG0765	amino acid transport
GFX43_001770	COG1126	abc transporter atp-binding protein
GFX43_001780	COG2079	MmgE PrpD family protein
GFX43_001785	COG3192	ethanolamine utilization protein
GFX43_001795	COG2390	Transcriptional regulator
GFX43_001800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFX43_001805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GFX43_001810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GFX43_001815	COG0833	amino acid
GFX43_001820	COG0010	Belongs to the arginase family
GFX43_001825	COG1228	amidohydrolase
GFX43_001830	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GFX43_001835	COG2986	histidine ammonia-lyase
GFX43_001850	COG3507	Belongs to the glycosyl hydrolase 43 family
GFX43_001855	COG0494	nUDIX hydrolase
GFX43_001880	COG5444	nuclease activity
GFX43_001935	COG2190	(PTS) system
GFX43_001935	COG1263	PTS System
GFX43_001935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_001940	COG2723	6-phospho-beta-galactosidase activity
GFX43_001945	COG0589	response to stress
GFX43_001950	COG0697	spore germination
GFX43_001970	COG3401	FG-GAP repeat protein
GFX43_001970	COG2755	lipolytic protein G-D-S-L family
GFX43_001975	COG0513	Belongs to the DEAD box helicase family
GFX43_001980	COG2270	Major facilitator Superfamily
GFX43_001990	COG3711	transcriptional antiterminator
GFX43_001995	COG2273	Hydrolase Family 16
GFX43_002000	COG2851	Citrate transporter
GFX43_002005	COG0753	catalase activity
GFX43_002005	COG0693	protein deglycase activity
GFX43_002020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GFX43_002025	COG0500	methyltransferase
GFX43_002030	COG2610	gluconate transmembrane transporter activity
GFX43_002035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GFX43_002040	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GFX43_002045	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_002050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFX43_002055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFX43_002060	COG4894	glucomannan catabolic process
GFX43_002070	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFX43_002075	COG2197	response regulator
GFX43_002080	COG4585	Histidine kinase
GFX43_002090	COG0583	DNA-binding transcription factor activity
GFX43_002095	COG1881	PFAM PEBP family protein
GFX43_002100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFX43_002110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFX43_002115	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_002120	COG2508	Transcriptional regulator
GFX43_002125	COG3842	ATPase activity
GFX43_002130	COG0726	polysaccharide deacetylase
GFX43_002140	COG0501	Belongs to the peptidase M48B family
GFX43_002145	COG3493	citrate carrier protein
GFX43_002150	COG1271	oxidase subunit
GFX43_002155	COG1294	oxidase, subunit
GFX43_002160	COG4988	ABC transporter
GFX43_002165	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GFX43_002170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFX43_002175	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GFX43_002180	COG1595	DNA-templated transcription, initiation
GFX43_002200	COG1131	(ABC) transporter
GFX43_002205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GFX43_002210	COG2814	Major facilitator Superfamily
GFX43_002215	COG0753	catalase activity
GFX43_002220	COG2094	Belongs to the DNA glycosylase MPG family
GFX43_002230	COG3711	transcriptional antiterminator
GFX43_002230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFX43_002235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFX43_002240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFX43_002245	COG1447	Phosphotransferase system cellobiose-specific component IIA
GFX43_002250	COG1486	melibiose metabolic process
GFX43_002255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFX43_002260	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GFX43_002265	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GFX43_002270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFX43_002275	COG1696	Membrane protein involved in D-alanine export
GFX43_002280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_002295	COG1575	Belongs to the MenA family. Type 1 subfamily
GFX43_002300	COG2357	RelA SpoT domain protein
GFX43_002305	COG2234	aminopeptidase activity
GFX43_002310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFX43_002315	COG1846	Transcriptional regulator
GFX43_002320	COG5522	Integral membrane protein (intg_mem_TP0381)
GFX43_002325	COG1442	glycosyl transferase family 8
GFX43_002330	COG3711	transcriptional antiterminator
GFX43_002335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_002335	COG1263	PTS System
GFX43_002340	COG1404	Belongs to the peptidase S8 family
GFX43_002345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFX43_002355	COG0346	lactoylglutathione lyase activity
GFX43_002360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GFX43_002365	COG4895	conserved protein (DUF2196)
GFX43_002370	COG2814	Major facilitator Superfamily
GFX43_002375	COG1346	cytolysis
GFX43_002380	COG1380	Effector of murein hydrolase LrgA
GFX43_002385	COG0583	DNA-binding transcription factor activity
GFX43_002390	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GFX43_002395	COG0352	thiamine-phosphate diphosphorylase activity
GFX43_002400	COG0672	)-iron permease
GFX43_002405	COG2822	iron ion transport
GFX43_002410	COG2837	iron assimilation
GFX43_002415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GFX43_002420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFX43_002425	COG3162	membrane
GFX43_002435	COG1309	transcriptional regulator
GFX43_002440	COG2246	polysaccharide biosynthetic process
GFX43_002445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GFX43_002450	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GFX43_002455	COG2261	transglycosylase associated protein
GFX43_002460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GFX43_002465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFX43_002470	COG1845	cytochrome c oxidase, subunit III
GFX43_002475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GFX43_002485	COG0772	Belongs to the SEDS family
GFX43_002490	COG0778	Nitroreductase
GFX43_002495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFX43_002500	COG1404	Belongs to the peptidase S8 family
GFX43_002510	COG3711	transcriptional antiterminator
GFX43_002520	COG1263	PTS System
GFX43_002520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_002525	COG1621	beta-fructofuranosidase activity
GFX43_002535	COG0351	phosphomethylpyrimidine kinase
GFX43_002540	COG1216	Glycosyl transferase, family 2
GFX43_002545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFX43_002550	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_002560	COG2233	PERMEase
GFX43_002565	COG2363	Small membrane protein
GFX43_002575	COG0463	Glycosyl transferase, family 2
GFX43_002580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GFX43_002585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFX43_002590	COG0456	acetyltransferase
GFX43_002595	COG2089	acid synthase
GFX43_002600	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GFX43_002605	COG3980	spore coat polysaccharide biosynthesis protein
GFX43_002610	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFX43_002615	COG1088	dTDP-glucose 4,6-dehydratase activity
GFX43_002620	COG1091	dTDP-4-dehydrorhamnose reductase activity
GFX43_002625	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GFX43_002635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFX43_002640	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_002645	COG4187	Peptidase family M20/M25/M40
GFX43_002650	COG0833	amino acid
GFX43_002655	COG2814	Major facilitator Superfamily
GFX43_002660	COG0077	Prephenate dehydratase
GFX43_002665	COG1917	Cupin 2, conserved barrel domain protein
GFX43_002670	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_002675	COG0151	Belongs to the GarS family
GFX43_002680	COG2814	Major facilitator Superfamily
GFX43_002685	COG0436	Aminotransferase
GFX43_002690	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_002700	COG0280	phosphate acetyltransferase
GFX43_002705	COG0583	DNA-binding transcription factor activity
GFX43_002710	COG0095	Lipoate-protein ligase
GFX43_002715	COG0697	spore germination
GFX43_002725	COG4844	belongs to the
GFX43_002730	COG1078	dGTPase activity
GFX43_002735	COG3465	dGTPase activity
GFX43_002740	COG1959	2 iron, 2 sulfur cluster binding
GFX43_002745	COG0477	Major facilitator Superfamily
GFX43_002755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFX43_002760	COG1846	Transcriptional regulator
GFX43_002765	COG1942	4-Oxalocrotonate Tautomerase
GFX43_002770	COG1994	Peptidase M50
GFX43_002780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFX43_002785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GFX43_002790	COG0010	Belongs to the arginase family
GFX43_002800	COG1131	(ABC) transporter
GFX43_002820	COG0457	Tetratricopeptide repeat
GFX43_002830	COG3391	amine dehydrogenase activity
GFX43_002835	COG3391	amine dehydrogenase activity
GFX43_002845	COG0612	Peptidase, M16
GFX43_002850	COG0612	Peptidase, M16
GFX43_002855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFX43_002860	COG1131	(ABC) transporter
GFX43_002870	COG0535	radical SAM domain protein
GFX43_002885	COG4506	Protein conserved in bacteria
GFX43_002890	COG0018	arginyl-trna synthetase
GFX43_002895	COG2223	nitrite transmembrane transporter activity
GFX43_002900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFX43_002910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFX43_002915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GFX43_002920	COG1140	nitrate reductase beta subunit
GFX43_002925	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GFX43_002930	COG2181	nitrate reductase activity
GFX43_002940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFX43_002945	COG1132	(ABC) transporter
GFX43_002950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFX43_002960	COG4294	response to UV
GFX43_002965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFX43_002970	COG0247	lactate metabolic process
GFX43_002970	COG2181	nitrate reductase activity
GFX43_002975	COG1960	acyl-CoA dehydrogenase activity
GFX43_002980	COG3343	RNA polymerase activity
GFX43_002985	COG0504	CTP synthase activity
GFX43_002990	COG4821	SIS domain
GFX43_002995	COG2204	response regulator
GFX43_003000	COG0191	fructose-bisphosphate aldolase activity
GFX43_003005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFX43_003015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFX43_003020	COG1494	fructose-1,6-bisphosphatase
GFX43_003030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GFX43_003035	COG0254	rRNA binding
GFX43_003040	COG1435	thymidine kinase activity
GFX43_003045	COG0281	malic enzyme
GFX43_003050	COG0679	Auxin Efflux Carrier
GFX43_003055	COG0789	Transcriptional regulator
GFX43_003060	COG0346	lactoylglutathione lyase activity
GFX43_003065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFX43_003070	COG2890	protein-(glutamine-N5) methyltransferase activity
GFX43_003090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GFX43_003095	COG0009	L-threonylcarbamoyladenylate synthase
GFX43_003100	COG1971	Probably functions as a manganese efflux pump
GFX43_003105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFX43_003110	COG0698	ribose 5-phosphate isomerase
GFX43_003115	COG4475	Protein of unknown function (DUF436)
GFX43_003120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFX43_003125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFX43_003135	COG0356	it plays a direct role in the translocation of protons across the membrane
GFX43_003140	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFX43_003145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFX43_003150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFX43_003155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFX43_003160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFX43_003165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFX43_003170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFX43_003180	COG4836	Membrane
GFX43_003190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFX43_003195	COG2385	sporulation resulting in formation of a cellular spore
GFX43_003200	COG2304	oxidoreductase activity
GFX43_003210	COG2304	oxidoreductase activity
GFX43_003220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GFX43_003225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFX43_003230	COG0457	Tetratricopeptide repeat
GFX43_003235	COG1994	Peptidase M50
GFX43_003240	COG3237	CsbD-like
GFX43_003255	COG0831	urea catabolic process
GFX43_003260	COG0832	Belongs to the urease beta subunit family
GFX43_003265	COG0804	urea catabolic process
GFX43_003270	COG1959	2 iron, 2 sulfur cluster binding
GFX43_003275	COG2910	NAD(P)H-binding
GFX43_003285	COG0789	Transcriptional regulator
GFX43_003290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFX43_003300	COG2089	acid synthase
GFX43_003310	COG1247	-acetyltransferase
GFX43_003315	COG0739	heme binding
GFX43_003325	COG0671	phosphoesterase, PA-phosphatase related
GFX43_003330	COG0347	Belongs to the P(II) protein family
GFX43_003335	COG0004	ammonium transporteR
GFX43_003345	COG1335	isochorismatase
GFX43_003350	COG0477	Major facilitator Superfamily
GFX43_003355	COG1953	Uracil, thiamine, allantoin
GFX43_003360	COG3420	alginic acid biosynthetic process
GFX43_003365	COG2814	Major facilitator Superfamily
GFX43_003370	COG1846	Transcriptional regulator
GFX43_003380	COG1609	Transcriptional regulator
GFX43_003385	COG1077	Cell shape determining protein MreB Mrl
GFX43_003390	COG4786	Flagellar basal body rod
GFX43_003395	COG4786	Flagellar basal body rod
GFX43_003400	COG0457	Tetratricopeptide repeat
GFX43_003405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFX43_003410	COG1970	mechanosensitive ion channel activity
GFX43_003415	COG2972	Histidine kinase
GFX43_003415	COG0745	RESPONSE REGULATOR receiver
GFX43_003420	COG3279	Response regulator of the LytR AlgR family
GFX43_003430	COG3764	Sortase (surface protein transpeptidase)
GFX43_003445	COG0629	single-stranded DNA binding
GFX43_003450	COG1349	DNA-binding transcription factor activity
GFX43_003455	COG0561	phosphatase activity
GFX43_003460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFX43_003465	COG4715	Zinc finger, swim domain protein
GFX43_003475	COG3944	biosynthesis protein
GFX43_003480	COG0489	protein tyrosine kinase activity
GFX43_003485	COG4464	protein tyrosine phosphatase activity
GFX43_003490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFX43_003495	COG3878	Protein conserved in bacteria
GFX43_003510	COG5444	nuclease activity
GFX43_003540	COG2059	Chromate
GFX43_003545	COG2059	Chromate
GFX43_003550	COG1522	sequence-specific DNA binding
GFX43_003555	COG0405	Gamma-glutamyltransferase
GFX43_003565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFX43_003575	COG5337	Spore coat protein CotH
GFX43_003590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GFX43_003595	COG0583	DNA-binding transcription factor activity
GFX43_003600	COG0028	Belongs to the TPP enzyme family
GFX43_003605	COG3527	Alpha-acetolactate decarboxylase
GFX43_003610	COG2249	NAD(P)H dehydrogenase (quinone) activity
GFX43_003620	COG3103	Sh3 type 3 domain protein
GFX43_003625	COG1879	ABC-type sugar transport system periplasmic component
GFX43_003630	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFX43_003635	COG1129	ABC transporter
GFX43_003640	COG1869	D-ribose catabolic process
GFX43_003645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFX43_003650	COG1609	Transcriptional regulator
GFX43_003665	COG2843	Capsule synthesis protein
GFX43_003675	COG0791	NLP P60 protein
GFX43_003680	COG0561	phosphatase activity
GFX43_003685	COG1316	TRANSCRIPTIONal
GFX43_003690	COG2814	Major facilitator Superfamily
GFX43_003700	COG0814	amino acid
GFX43_003705	COG0697	spore germination
GFX43_003710	COG1482	cell wall glycoprotein biosynthetic process
GFX43_003715	COG4193	domain, Protein
GFX43_003760	COG0463	Glycosyl transferase, family 2
GFX43_003780	COG1682	transport, permease protein
GFX43_003785	COG1134	teichoic acid transport
GFX43_003790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GFX43_003810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GFX43_003815	COG1316	TRANSCRIPTIONal
GFX43_003825	COG2247	cell wall binding repeat
GFX43_003825	COG2385	sporulation resulting in formation of a cellular spore
GFX43_003830	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFX43_003830	COG2247	cell wall binding repeat
GFX43_003845	COG2244	polysaccharide biosynthetic process
GFX43_003850	COG0438	transferase activity, transferring glycosyl groups
GFX43_003850	COG0297	glycogen (starch) synthase activity
GFX43_003855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFX43_003860	COG3307	-O-antigen
GFX43_003865	COG3206	protein involved in exopolysaccharide biosynthesis
GFX43_003870	COG1215	transferase activity, transferring glycosyl groups
GFX43_003875	COG0438	transferase activity, transferring glycosyl groups
GFX43_003880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFX43_003885	COG1316	TRANSCRIPTIONal
GFX43_003890	COG1739	Uncharacterized protein family UPF0029
GFX43_003895	COG4585	Histidine kinase
GFX43_003900	COG2197	response regulator
GFX43_003905	COG1307	EDD domain protein, DegV family
GFX43_003910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GFX43_003920	COG1040	competence protein
GFX43_003930	COG2747	anti-sigma28 factor FlgM
GFX43_003935	COG3418	PFAM FlgN family protein
GFX43_003940	COG4786	Flagellar basal body rod
GFX43_003940	COG1256	bacterial-type flagellum assembly
GFX43_003945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GFX43_003955	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GFX43_003960	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GFX43_003965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GFX43_003970	COG1334	flagellar protein FlaG
GFX43_003975	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GFX43_003980	COG1516	flagellar protein fliS
GFX43_003995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GFX43_004000	COG0653	protein targeting
GFX43_004010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFX43_004015	COG2010	Cytochrome c
GFX43_004020	COG2884	Cell division ATP-binding protein ftsE
GFX43_004025	COG2177	Part of the ABC transporter FtsEX involved in
GFX43_004030	COG3409	Peptidoglycan-binding domain 1 protein
GFX43_004030	COG0793	Belongs to the peptidase S41A family
GFX43_004040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFX43_004045	COG2814	Major facilitator Superfamily
GFX43_004050	COG1309	transcriptional regulator
GFX43_004055	COG3848	Pyruvate phosphate dikinase
GFX43_004055	COG0574	Belongs to the PEP-utilizing enzyme family
GFX43_004060	COG4897	Protein conserved in bacteria
GFX43_004065	COG0556	nucleotide-excision repair
GFX43_004070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFX43_004075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GFX43_004090	COG3595	metallopeptidase activity
GFX43_004095	COG1983	PspC domain protein
GFX43_004100	COG1950	PFAM Membrane protein of
GFX43_004105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GFX43_004115	COG0363	glucosamine-6-phosphate deaminase activity
GFX43_004120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GFX43_004125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GFX43_004130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFX43_004135	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GFX43_004140	COG0546	phosphoglycolate phosphatase activity
GFX43_004145	COG0110	maltose O-acetyltransferase activity
GFX43_004150	COG5297	Belongs to the glycosyl hydrolase family 6
GFX43_004155	COG4990	cell redox homeostasis
GFX43_004160	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GFX43_004165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFX43_004170	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFX43_004175	COG0131	Imidazoleglycerol-phosphate dehydratase
GFX43_004180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFX43_004185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFX43_004190	COG0107	imidazoleglycerol-phosphate synthase activity
GFX43_004195	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFX43_004195	COG0140	phosphoribosyl-ATP diphosphatase activity
GFX43_004215	COG1132	(ABC) transporter
GFX43_004220	COG0457	Tetratricopeptide repeat
GFX43_004225	COG0791	NLP P60 protein
GFX43_004225	COG3883	PFAM NLP P60 protein
GFX43_004230	COG0492	ferredoxin-NADP+ reductase activity
GFX43_004235	COG1051	belongs to the nudix hydrolase family
GFX43_004240	COG1660	Displays ATPase and GTPase activities
GFX43_004245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GFX43_004250	COG1481	regulation of sporulation
GFX43_004255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFX43_004260	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GFX43_004270	COG0745	RESPONSE REGULATOR receiver
GFX43_004275	COG5002	protein histidine kinase activity
GFX43_004280	COG1136	(ABC) transporter
GFX43_004285	COG0577	efflux transmembrane transporter activity
GFX43_004290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFX43_004295	COG0288	reversible hydration of carbon dioxide
GFX43_004300	COG0659	secondary active sulfate transmembrane transporter activity
GFX43_004305	COG1694	Mazg nucleotide pyrophosphohydrolase
GFX43_004310	COG1611	Belongs to the LOG family
GFX43_004315	COG1609	Transcriptional regulator
GFX43_004320	COG0366	Alpha amylase catalytic
GFX43_004325	COG2182	Extracellular solute-binding protein
GFX43_004330	COG1175	transmembrane transport
GFX43_004335	COG3833	ABC-type maltose transport systems, permease component
GFX43_004340	COG5521	maltodextrose utilization protein MalA
GFX43_004345	COG1554	hydrolase, family 65, central catalytic
GFX43_004350	COG0366	Alpha amylase catalytic
GFX43_004355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFX43_004360	COG0740	serine-type endopeptidase activity
GFX43_004400	COG2076	Multidrug Resistance protein
GFX43_004405	COG2076	Multidrug Resistance protein
GFX43_004410	COG1309	transcriptional regulator
GFX43_004415	COG0531	amino acid
GFX43_004420	COG1621	beta-fructofuranosidase activity
GFX43_004425	COG1621	beta-fructofuranosidase activity
GFX43_004440	COG1794	racemase activity, acting on amino acids and derivatives
GFX43_004450	COG3479	Phenolic acid decarboxylase
GFX43_004460	COG2272	Belongs to the type-B carboxylesterase lipase family
GFX43_004465	COG1396	sequence-specific DNA binding
GFX43_004470	COG3944	biosynthesis protein
GFX43_004475	COG0489	protein tyrosine kinase activity
GFX43_004480	COG1086	Polysaccharide biosynthesis protein
GFX43_004485	COG0438	transferase activity, transferring glycosyl groups
GFX43_004490	COG1215	transferase activity, transferring glycosyl groups
GFX43_004495	COG0438	transferase activity, transferring glycosyl groups
GFX43_004505	COG1216	Glycosyl transferase, family 2
GFX43_004510	COG5039	Polysaccharide pyruvyl transferase
GFX43_004515	COG1216	Glycosyl transferase, family 2
GFX43_004520	COG2244	polysaccharide biosynthetic process
GFX43_004525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFX43_004530	COG0110	maltose O-acetyltransferase activity
GFX43_004535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFX43_004540	COG5039	Polysaccharide pyruvyl transferase
GFX43_004550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GFX43_004555	COG1620	l-lactate permease
GFX43_004560	COG2186	Transcriptional regulator
GFX43_004565	COG1609	Transcriptional regulator
GFX43_004570	COG2182	Extracellular solute-binding protein
GFX43_004575	COG1175	transmembrane transport
GFX43_004580	COG3833	ABC-type maltose transport systems, permease component
GFX43_004585	COG1874	Beta-galactosidase
GFX43_004590	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GFX43_004595	COG2208	phosphoserine phosphatase activity
GFX43_004600	COG0596	Alpha beta hydrolase
GFX43_004605	COG1131	(ABC) transporter
GFX43_004610	COG0842	Transport permease protein
GFX43_004615	COG4585	Histidine kinase
GFX43_004620	COG2197	response regulator
GFX43_004625	COG0247	lactate metabolic process
GFX43_004630	COG1139	Iron-sulfur cluster binding protein
GFX43_004635	COG1556	Lactate utilization protein
GFX43_004640	COG3858	chitin binding
GFX43_004645	COG1113	amino acid transport
GFX43_004650	COG0697	spore germination
GFX43_004655	COG0583	DNA-binding transcription factor activity
GFX43_004660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFX43_004665	COG1609	Transcriptional regulator
GFX43_004670	COG2814	Major facilitator Superfamily
GFX43_004675	COG2390	Transcriptional regulator
GFX43_004680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFX43_004685	COG0126	phosphoglycerate kinase activity
GFX43_004690	COG0149	triose-phosphate isomerase activity
GFX43_004695	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GFX43_004700	COG0148	phosphopyruvate hydratase activity
GFX43_004705	COG2234	aminopeptidase activity
GFX43_004715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFX43_004720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFX43_004740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFX43_004755	COG0456	acetyltransferase
GFX43_004760	COG4640	response to antibiotic
GFX43_004765	COG3064	Membrane
GFX43_004775	COG2095	MarC family integral membrane protein
GFX43_004780	COG1510	regulation of RNA biosynthetic process
GFX43_004785	COG0517	IMP dehydrogenase activity
GFX43_004785	COG1125	glycine betaine transport
GFX43_004790	COG1174	glycine betaine transport
GFX43_004795	COG1732	Glycine betaine
GFX43_004800	COG1174	glycine betaine transport
GFX43_004805	COG1510	regulation of RNA biosynthetic process
GFX43_004810	COG1125	glycine betaine transport
GFX43_004810	COG0517	IMP dehydrogenase activity
GFX43_004815	COG1174	glycine betaine transport
GFX43_004820	COG1732	Glycine betaine
GFX43_004825	COG1174	glycine betaine transport
GFX43_004850	COG1733	regulation of RNA biosynthetic process
GFX43_004855	COG1396	sequence-specific DNA binding
GFX43_004860	COG1396	sequence-specific DNA binding
GFX43_004865	COG1476	TRANSCRIPTIONal
GFX43_004870	COG0596	Alpha beta hydrolase
GFX43_004875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFX43_004880	COG1647	Serine aminopeptidase, S33
GFX43_004885	COG0557	exoribonuclease II activity
GFX43_004890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GFX43_004900	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_004905	COG1309	transcriptional regulator
GFX43_004910	COG2076	Multidrug Resistance protein
GFX43_004920	COG1289	transmembrane transporter activity
GFX43_004925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GFX43_004930	COG0673	inositol 2-dehydrogenase activity
GFX43_004935	COG1937	Protein conserved in bacteria
GFX43_004940	COG2608	mercury ion transmembrane transporter activity
GFX43_004945	COG2217	Heavy metal translocating P-type atpase
GFX43_004950	COG2217	Heavy metal translocating P-type atpase
GFX43_004955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GFX43_004960	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GFX43_004965	COG2860	membrane
GFX43_004975	COG3973	AAA domain
GFX43_004980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GFX43_004985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFX43_004990	COG0025	NhaP-type Na H and K H
GFX43_005000	COG0656	L-ascorbic acid biosynthetic process
GFX43_005005	COG4149	molybdate abc transporter
GFX43_005010	COG0725	ABC transporter, periplasmic molybdate-binding protein
GFX43_005015	COG1910	domain protein
GFX43_005020	COG1368	sulfuric ester hydrolase activity
GFX43_005025	COG1988	membrane-bound metal-dependent
GFX43_005035	COG0531	amino acid
GFX43_005040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFX43_005045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_005050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_005055	COG1120	ATPase activity
GFX43_005060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFX43_005065	COG1136	(ABC) transporter
GFX43_005070	COG0577	efflux transmembrane transporter activity
GFX43_005080	COG2140	Oxalate decarboxylase
GFX43_005090	COG1191	sigma factor activity
GFX43_005100	COG0745	RESPONSE REGULATOR receiver
GFX43_005105	COG2205	protein histidine kinase activity
GFX43_005110	COG3386	PFAM SMP-30 Gluconolaconase
GFX43_005115	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_005120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFX43_005125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_005130	COG1120	ATPase activity
GFX43_005135	COG2096	Adenosyltransferase
GFX43_005140	COG2814	Major facilitator Superfamily
GFX43_005145	COG4758	membrane
GFX43_005150	COG1842	Phage shock protein A
GFX43_005155	COG3595	metallopeptidase activity
GFX43_005160	COG4758	membrane
GFX43_005165	COG4585	Histidine kinase
GFX43_005170	COG2197	response regulator
GFX43_005180	COG0814	amino acid
GFX43_005185	COG0697	spore germination
GFX43_005195	COG0114	fumarate hydratase activity
GFX43_005200	COG1309	transcriptional regulator
GFX43_005210	COG2770	Histidine kinase
GFX43_005210	COG2205	protein histidine kinase activity
GFX43_005215	COG0745	RESPONSE REGULATOR receiver
GFX43_005220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFX43_005225	COG0783	Belongs to the Dps family
GFX43_005230	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_005245	COG1120	ATPase activity
GFX43_005255	COG0583	DNA-binding transcription factor activity
GFX43_005260	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_005265	COG1942	4-Oxalocrotonate Tautomerase
GFX43_005270	COG0477	Major facilitator Superfamily
GFX43_005275	COG1846	Transcriptional regulator
GFX43_005280	COG5577	PFAM Coat F domain
GFX43_005290	COG0506	proline dehydrogenase activity
GFX43_005300	COG1024	Enoyl-CoA hydratase
GFX43_005300	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFX43_005305	COG0183	Belongs to the thiolase family
GFX43_005310	COG1960	acyl-CoA dehydrogenase activity
GFX43_005315	COG1393	Belongs to the ArsC family
GFX43_005320	COG0509	glycine decarboxylation via glycine cleavage system
GFX43_005330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GFX43_005335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFX43_005345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GFX43_005350	COG2011	ABC-type metal ion transport system permease component
GFX43_005355	COG1464	Belongs to the NlpA lipoprotein family
GFX43_005360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFX43_005370	COG0396	ATPase activity
GFX43_005375	COG0719	Fe-S assembly protein
GFX43_005380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFX43_005385	COG0822	iron-sulfur transferase activity
GFX43_005390	COG0719	Fe-S assembly protein
GFX43_005395	COG0640	Transcriptional regulator
GFX43_005400	COG0346	lactoylglutathione lyase activity
GFX43_005415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFX43_005420	COG0322	excinuclease ABC activity
GFX43_005425	COG2222	sugar isomerase
GFX43_005430	COG1653	transport
GFX43_005435	COG1175	transmembrane transport
GFX43_005440	COG0395	ABC-type sugar transport system, permease component
GFX43_005445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFX43_005450	COG2188	Transcriptional regulator
GFX43_005455	COG3842	ATPase activity
GFX43_005460	COG2356	endonuclease I
GFX43_005470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFX43_005475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GFX43_005480	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFX43_005485	COG2068	MobA-Related Protein
GFX43_005490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GFX43_005495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GFX43_005500	COG2080	2 iron, 2 sulfur cluster binding
GFX43_005510	COG2351	hydroxyisourate hydrolase activity
GFX43_005515	COG3648	Uricase
GFX43_005515	COG3195	allantoin biosynthetic process
GFX43_005520	COG2233	PERMEase
GFX43_005525	COG2233	PERMEase
GFX43_005530	COG2508	Transcriptional regulator
GFX43_005535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFX43_005545	COG1801	Protein of unknown function DUF72
GFX43_005550	COG0730	response to heat
GFX43_005555	COG0737	Belongs to the 5'-nucleotidase family
GFX43_005560	COG3377	Domain of unknown function (DUF1805)
GFX43_005570	COG0739	heme binding
GFX43_005575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFX43_005585	COG4470	Protein conserved in bacteria
GFX43_005590	COG2445	Protein of unknown function DUF86
GFX43_005595	COG0647	UMP catabolic process
GFX43_005600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GFX43_005605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GFX43_005610	COG0460	homoserine dehydrogenase
GFX43_005615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFX43_005620	COG0083	homoserine kinase activity
GFX43_005625	COG4946	Tricorn protease homolog
GFX43_005625	COG0823	Involved in the tonB-independent uptake of proteins
GFX43_005625	COG1506	peptidase
GFX43_005630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GFX43_005635	COG4837	Protein of unknown function (DUF1462)
GFX43_005640	COG1252	NADH dehydrogenase
GFX43_005645	COG4844	belongs to the
GFX43_005650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GFX43_005655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFX43_005660	COG0316	Belongs to the HesB IscA family
GFX43_005665	COG0456	acetyltransferase
GFX43_005670	COG2808	Putative FMN-binding domain
GFX43_005675	COG0516	GMP reductase activity
GFX43_005685	COG0492	ferredoxin-NADP+ reductase activity
GFX43_005690	COG1252	NADH dehydrogenase
GFX43_005705	COG3584	3D domain protein
GFX43_005710	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GFX43_005715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GFX43_005720	COG2056	Na+-H+ antiporter family
GFX43_005725	COG1268	BioY protein
GFX43_005730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFX43_005735	COG2819	hydrolase of the alpha beta superfamily
GFX43_005740	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_005745	COG1169	isochorismate synthase
GFX43_005750	COG1021	2,3-dihydroxybenzoate-AMP ligase
GFX43_005755	COG3433	isochorismatase activity
GFX43_005755	COG1535	isochorismatase
GFX43_005760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_005765	COG3251	PFAM MbtH domain protein
GFX43_005770	COG5634	Uncharacterized conserved protein (DUF2278)
GFX43_005775	COG0686	Belongs to the AlaDH PNT family
GFX43_005780	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GFX43_005780	COG2508	Transcriptional regulator
GFX43_005785	COG4842	Belongs to the WXG100 family
GFX43_005790	COG5417	Belongs to the EsaB family
GFX43_005795	COG4499	WXG100 protein secretion system (Wss), protein YukC
GFX43_005800	COG0433	COG0433 Predicted ATPase
GFX43_005800	COG1674	ftsk spoiiie
GFX43_005805	COG1511	domain protein
GFX43_005815	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_005820	COG1418	mRNA catabolic process
GFX43_005835	COG0628	permease
GFX43_005850	COG5506	Protein of unknown function (DUF1694)
GFX43_005855	COG1335	isochorismatase
GFX43_005860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GFX43_005865	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GFX43_005880	COG0142	geranyltranstransferase activity
GFX43_005890	COG4585	Histidine kinase
GFX43_005895	COG2197	response regulator
GFX43_005900	COG2050	protein possibly involved in aromatic compounds catabolism
GFX43_005905	COG1320	monovalent cation:proton antiporter activity
GFX43_005910	COG2212	antiporter activity
GFX43_005915	COG1863	multisubunit Na H antiporter MnhE subunit
GFX43_005920	COG0651	ATP synthesis coupled electron transport
GFX43_005925	COG1006	Multisubunit Na H antiporter MnhC subunit
GFX43_005930	COG2111	Na H antiporter
GFX43_005935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFX43_005935	COG2111	Na H antiporter
GFX43_005945	COG3493	citrate carrier protein
GFX43_005970	COG4565	transcriptional regulatory protein
GFX43_005975	COG3290	protein histidine kinase activity
GFX43_005985	COG3011	Protein conserved in bacteria
GFX43_005990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFX43_005995	COG2814	Major facilitator Superfamily
GFX43_006005	COG5018	Exonuclease
GFX43_006015	COG2205	protein histidine kinase activity
GFX43_006020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GFX43_006030	COG2267	carboxylic ester hydrolase activity
GFX43_006035	COG1522	sequence-specific DNA binding
GFX43_006040	COG0436	Aminotransferase
GFX43_006045	COG1098	S1 RNA binding domain
GFX43_006050	COG2155	Conserved Protein
GFX43_006055	COG1979	alcohol dehydrogenase
GFX43_006060	COG1979	alcohol dehydrogenase
GFX43_006065	COG0166	Belongs to the GPI family
GFX43_006080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFX43_006095	COG2738	Putative neutral zinc metallopeptidase
GFX43_006100	COG1253	flavin adenine dinucleotide binding
GFX43_006105	COG0366	Alpha amylase catalytic
GFX43_006110	COG0432	Pfam Uncharacterised protein family UPF0047
GFX43_006130	COG0840	transmembrane signaling receptor activity
GFX43_006135	COG0840	transmembrane signaling receptor activity
GFX43_006140	COG0840	transmembrane signaling receptor activity
GFX43_006145	COG0840	transmembrane signaling receptor activity
GFX43_006150	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_006150	COG3347	Dehydrogenase
GFX43_006155	COG1349	DNA-binding transcription factor activity
GFX43_006160	COG1070	Carbohydrate kinase
GFX43_006165	COG3254	rhamnose metabolic process
GFX43_006170	COG4806	L-rhamnose isomerase
GFX43_006175	COG0673	inositol 2-dehydrogenase activity
GFX43_006180	COG0628	permease
GFX43_006185	COG1968	undecaprenyl-diphosphatase activity
GFX43_006195	COG5553	Cysteine dioxygenase type I
GFX43_006200	COG0477	Major facilitator Superfamily
GFX43_006205	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFX43_006210	COG4682	membrane
GFX43_006215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFX43_006220	COG0569	domain protein
GFX43_006230	COG1510	regulation of RNA biosynthetic process
GFX43_006240	COG1454	alcohol dehydrogenase
GFX43_006250	COG2318	DinB family
GFX43_006255	COG1585	Membrane protein implicated in regulation of membrane protease activity
GFX43_006260	COG2268	Band 7 protein
GFX43_006270	COG3859	Proton-coupled thiamine transporter YuaJ
GFX43_006395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GFX43_006400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFX43_006405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFX43_006410	COG0297	glycogen (starch) synthase activity
GFX43_006415	COG0058	SHG alpha-glucan phosphorylase activity
GFX43_006420	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GFX43_006425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GFX43_006430	COG0438	transferase activity, transferring glycosyl groups
GFX43_006435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GFX43_006445	COG0438	transferase activity, transferring glycosyl groups
GFX43_006450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFX43_006455	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFX43_006460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GFX43_006465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GFX43_006470	COG1169	isochorismate synthase
GFX43_006475	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GFX43_006480	COG0596	Alpha beta hydrolase
GFX43_006485	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GFX43_006490	COG0318	PFAM AMP-dependent synthetase and ligase
GFX43_006495	COG4948	Mandelate Racemase Muconate Lactonizing
GFX43_006500	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFX43_006505	COG1121	(ABC) transporter
GFX43_006510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFX43_006510	COG1321	iron dependent repressor
GFX43_006515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFX43_006525	COG1294	oxidase, subunit
GFX43_006530	COG1271	oxidase subunit
GFX43_006535	COG0254	rRNA binding
GFX43_006540	COG0288	reversible hydration of carbon dioxide
GFX43_006545	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GFX43_006550	COG1854	S-ribosylhomocysteine lyase activity
GFX43_006565	COG0783	Belongs to the Dps family
GFX43_006570	COG4824	toxin secretion phage lysis holin
GFX43_006575	COG0494	nUDIX hydrolase
GFX43_006580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFX43_006585	COG1116	anion transmembrane transporter activity
GFX43_006590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFX43_006595	COG1506	peptidase
GFX43_006605	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GFX43_006610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFX43_006615	COG0367	asparagine synthase
GFX43_006620	COG1113	amino acid transport
GFX43_006625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GFX43_006630	COG2267	carboxylic ester hydrolase activity
GFX43_006640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GFX43_006645	COG1242	4 iron, 4 sulfur cluster binding
GFX43_006660	COG1725	Transcriptional regulator
GFX43_006665	COG1131	(ABC) transporter
GFX43_006680	COG1136	(ABC) transporter
GFX43_006685	COG0577	efflux transmembrane transporter activity
GFX43_006690	COG0745	RESPONSE REGULATOR receiver
GFX43_006695	COG2205	protein histidine kinase activity
GFX43_006700	COG1136	(ABC) transporter
GFX43_006705	COG0577	efflux transmembrane transporter activity
GFX43_006710	COG2433	Pfam Transposase IS66
GFX43_006715	COG2814	Major facilitator Superfamily
GFX43_006720	COG2202	Pas domain
GFX43_006720	COG1366	Belongs to the anti-sigma-factor antagonist family
GFX43_006730	COG0495	leucyl-tRNA aminoacylation
GFX43_006735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFX43_006740	COG1486	melibiose metabolic process
GFX43_006765	COG1073	alpha beta
GFX43_006775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFX43_006780	COG0156	8-amino-7-oxononanoate synthase activity
GFX43_006790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GFX43_006795	COG2124	cytochrome p450
GFX43_006800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFX43_006805	COG0395	ABC-type sugar transport system, permease component
GFX43_006810	COG1653	transport
GFX43_006815	COG2207	Transcriptional regulator
GFX43_006820	COG4209	transmembrane transport
GFX43_006825	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFX43_006830	COG1653	transport
GFX43_006835	COG0673	inositol 2-dehydrogenase activity
GFX43_006840	COG5578	integral membrane protein
GFX43_006850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GFX43_006855	COG2081	HI0933 family
GFX43_006860	COG2244	polysaccharide biosynthetic process
GFX43_006865	COG1187	pseudouridine synthase activity
GFX43_006870	COG1349	DNA-binding transcription factor activity
GFX43_006875	COG1131	(ABC) transporter
GFX43_006880	COG4473	ABC transporter
GFX43_006885	COG2252	PERMEase
GFX43_006890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFX43_006895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFX43_006900	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GFX43_006910	COG1597	lipid kinase activity
GFX43_006915	COG1523	belongs to the glycosyl hydrolase 13 family
GFX43_006920	COG0510	thiamine kinase activity
GFX43_006930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFX43_006935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFX43_006940	COG0281	malic enzyme
GFX43_006945	COG5584	Small secreted protein
GFX43_006950	COG1363	Peptidase, m42
GFX43_006965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFX43_006970	COG4848	Belongs to the UPF0354 family
GFX43_006975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFX43_006980	COG1674	ftsk spoiiie
GFX43_006985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFX43_006990	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GFX43_006995	COG4980	gas vesicle protein
GFX43_007000	COG3118	belongs to the thioredoxin family
GFX43_007005	COG1605	Chorismate mutase
GFX43_007005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GFX43_007010	COG1609	Transcriptional regulator
GFX43_007015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GFX43_007020	COG1360	Flagellar Motor Protein
GFX43_007025	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFX43_007030	COG0517	IMP dehydrogenase activity
GFX43_007035	COG0454	-acetyltransferase
GFX43_007040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFX43_007045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFX43_007050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFX43_007060	COG2203	Gaf domain
GFX43_007060	COG2199	diguanylate cyclase activity
GFX43_007065	COG1956	GAF domain-containing protein
GFX43_007070	COG1309	transcriptional regulator
GFX43_007075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GFX43_007080	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GFX43_007085	COG1114	Component of the transport system for branched-chain amino acids
GFX43_007090	COG1104	cysteine desulfurase activity
GFX43_007095	COG0301	tRNA thio-modification
GFX43_007105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFX43_007110	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GFX43_007115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFX43_007120	COG0616	signal peptide processing
GFX43_007125	COG1714	RDD family
GFX43_007135	COG3874	Sporulation protein YtfJ
GFX43_007140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GFX43_007145	COG0827	DNA restriction-modification system
GFX43_007155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GFX43_007160	COG0521	Mo-molybdopterin cofactor biosynthetic process
GFX43_007165	COG0137	argininosuccinate synthase activity
GFX43_007170	COG0165	Argininosuccinate lyase
GFX43_007180	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_007185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFX43_007190	COG0583	DNA-binding transcription factor activity
GFX43_007195	COG0454	-acetyltransferase
GFX43_007200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFX43_007205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFX43_007210	COG0765	amino acid transport
GFX43_007215	COG0765	amino acid transport
GFX43_007220	COG1126	abc transporter atp-binding protein
GFX43_007225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFX43_007230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GFX43_007235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFX43_007240	COG0196	riboflavin kinase activity
GFX43_007245	COG1473	amidohydrolase
GFX43_007250	COG0730	response to heat
GFX43_007255	COG4109	DRTGG domain
GFX43_007265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFX43_007285	COG0587	DNA-directed DNA polymerase activity
GFX43_007290	COG0281	malic enzyme
GFX43_007295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GFX43_007300	COG0825	malonyl-CoA metabolic process
GFX43_007305	COG0205	6-phosphofructokinase activity
GFX43_007310	COG0469	pyruvate kinase activity
GFX43_007315	COG3030	protein affecting phage T7 exclusion by the F plasmid
GFX43_007320	COG0628	permease
GFX43_007325	COG2707	UPF0756 membrane protein
GFX43_007330	COG0372	Belongs to the citrate synthase family
GFX43_007335	COG0538	isocitrate dehydrogenase activity
GFX43_007340	COG0039	L-malate dehydrogenase activity
GFX43_007345	COG0745	RESPONSE REGULATOR receiver
GFX43_007350	COG5002	protein histidine kinase activity
GFX43_007355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFX43_007355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFX43_007360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFX43_007365	COG1971	Probably functions as a manganese efflux pump
GFX43_007370	COG0237	dephospho-CoA kinase activity
GFX43_007375	COG0656	L-ascorbic acid biosynthetic process
GFX43_007380	COG2814	Major facilitator Superfamily
GFX43_007385	COG1733	regulation of RNA biosynthetic process
GFX43_007390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFX43_007395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GFX43_007400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFX43_007405	COG3611	Membrane attachment protein
GFX43_007410	COG1484	DNA-dependent DNA replication
GFX43_007415	COG0398	Pfam SNARE associated Golgi protein
GFX43_007425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFX43_007435	COG3275	phosphorelay sensor kinase activity
GFX43_007440	COG3279	Response regulator of the LytR AlgR family
GFX43_007445	COG1380	Effector of murein hydrolase LrgA
GFX43_007450	COG1346	cytolysis
GFX43_007460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFX43_007465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFX43_007470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFX43_007475	COG3326	Membrane
GFX43_007485	COG1363	Peptidase, m42
GFX43_007490	COG3507	Belongs to the glycosyl hydrolase 43 family
GFX43_007495	COG2160	L-arabinose isomerase activity
GFX43_007500	COG1069	ribulokinase activity
GFX43_007505	COG0235	Class ii aldolase
GFX43_007510	COG0647	UMP catabolic process
GFX43_007515	COG0371	Dehydrogenase
GFX43_007520	COG1653	transport
GFX43_007525	COG1175	transmembrane transport
GFX43_007530	COG0395	ABC-type sugar transport system, permease component
GFX43_007535	COG3534	alpha-L-arabinofuranosidase
GFX43_007540	COG1966	Carbon starvation protein
GFX43_007550	COG0346	lactoylglutathione lyase activity
GFX43_007555	COG0247	lactate metabolic process
GFX43_007560	COG0277	FAD linked oxidase domain protein
GFX43_007565	COG3835	regulator
GFX43_007575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFX43_007585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFX43_007590	COG0072	phenylalanine-tRNA ligase activity
GFX43_007590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFX43_007595	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFX43_007600	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GFX43_007605	COG1286	toxin biosynthetic process
GFX43_007610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GFX43_007610	COG1796	DNA polymerase
GFX43_007615	COG1193	negative regulation of DNA recombination
GFX43_007620	COG3766	membrane
GFX43_007625	COG0318	PFAM AMP-dependent synthetase and ligase
GFX43_007630	COG1309	transcriptional regulator
GFX43_007635	COG1024	Enoyl-CoA hydratase
GFX43_007640	COG2086	electron transfer activity
GFX43_007645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFX43_007650	COG3534	alpha-L-arabinofuranosidase
GFX43_007660	COG3118	belongs to the thioredoxin family
GFX43_007665	COG0322	excinuclease ABC activity
GFX43_007670	COG0527	aspartate kinase activity
GFX43_007675	COG1719	4-vinyl reductase, 4VR
GFX43_007680	COG2009	succinate dehydrogenase
GFX43_007685	COG1053	succinate dehydrogenase
GFX43_007690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GFX43_007695	COG0824	Thioesterase
GFX43_007700	COG2197	response regulator
GFX43_007705	COG1846	Transcriptional regulator
GFX43_007710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFX43_007715	COG5401	PFAM Sporulation and spore germination
GFX43_007720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GFX43_007725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFX43_007730	COG0622	Phosphoesterase
GFX43_007740	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GFX43_007745	COG0454	-acetyltransferase
GFX43_007755	COG0028	Belongs to the TPP enzyme family
GFX43_007760	COG0440	acetolactate synthase activity
GFX43_007765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFX43_007770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFX43_007775	COG0473	3-isopropylmalate dehydrogenase activity
GFX43_007780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFX43_007785	COG0066	3-isopropylmalate dehydratase activity
GFX43_007790	COG1477	protein flavinylation
GFX43_007790	COG0457	Tetratricopeptide repeat
GFX43_007795	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFX43_007800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFX43_007805	COG1067	ATP-dependent peptidase activity
GFX43_007805	COG0470	DNA polymerase III
GFX43_007810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFX43_007815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GFX43_007825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GFX43_007830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFX43_007835	COG0181	hydroxymethylbilane synthase activity
GFX43_007840	COG1587	Uroporphyrinogen-III synthase
GFX43_007845	COG0113	porphobilinogen synthase activity
GFX43_007850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFX43_007855	COG1388	LysM domain
GFX43_007860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GFX43_007870	COG0525	valine-tRNA ligase activity
GFX43_007875	COG0285	dihydrofolate synthase activity
GFX43_007880	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GFX43_007890	COG0424	maF-like protein
GFX43_007895	COG2003	Belongs to the UPF0758 family
GFX43_007900	COG1077	Cell shape determining protein MreB Mrl
GFX43_007905	COG1792	Involved in formation and maintenance of cell shape
GFX43_007910	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GFX43_007915	COG0850	regulation of cytokinetic process
GFX43_007920	COG2894	cell division
GFX43_007925	COG0739	heme binding
GFX43_007930	COG1994	Peptidase M50
GFX43_007935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFX43_007940	COG2868	ribosomal protein
GFX43_007945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFX43_007955	COG3290	protein histidine kinase activity
GFX43_007960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFX43_007965	COG4492	Belongs to the UPF0735 family
GFX43_007970	COG0077	Prephenate dehydratase
GFX43_007975	COG1827	regulation of RNA biosynthetic process
GFX43_007980	COG1104	cysteine desulfurase activity
GFX43_007985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GFX43_007990	COG0157	Belongs to the NadC ModD family
GFX43_007995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFX43_008000	COG1388	LysM domain
GFX43_008010	COG0217	transcriptional regulatory protein
GFX43_008015	COG1115	amino acid carrier protein
GFX43_008035	COG2112	serine threonine protein kinase
GFX43_008040	COG0673	inositol 2-dehydrogenase activity
GFX43_008045	COG2814	Major facilitator Superfamily
GFX43_008055	COG0632	four-way junction helicase activity
GFX43_008060	COG2255	four-way junction helicase activity
GFX43_008070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFX43_008075	COG0343	queuine tRNA-ribosyltransferase activity
GFX43_008080	COG1862	Preprotein translocase
GFX43_008090	COG2323	membrane
GFX43_008095	COG2244	polysaccharide biosynthetic process
GFX43_008105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFX43_008105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFX43_008110	COG0490	domain, Protein
GFX43_008115	COG5416	Lipopolysaccharide assembly protein A domain
GFX43_008120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFX43_008120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFX43_008125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFX43_008130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFX43_008135	COG1490	D-aminoacyl-tRNA deacylase activity
GFX43_008140	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFX43_008140	COG3103	Sh3 type 3 domain protein
GFX43_008140	COG4991	sh3 domain protein
GFX43_008150	COG0124	histidyl-tRNA synthetase
GFX43_008155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFX43_008165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GFX43_008170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFX43_008175	COG1959	2 iron, 2 sulfur cluster binding
GFX43_008180	COG1104	cysteine desulfurase activity
GFX43_008185	COG0482	sulfurtransferase activity
GFX43_008190	COG0457	Tetratricopeptide repeat
GFX43_008195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFX43_008200	COG3881	PFAM PRC-barrel domain
GFX43_008215	COG0765	amino acid transport
GFX43_008220	COG0765	amino acid transport
GFX43_008225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFX43_008230	COG1126	abc transporter atp-binding protein
GFX43_008235	COG0628	permease
GFX43_008240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFX43_008245	COG4472	Bacterial protein of unknown function (DUF965)
GFX43_008250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFX43_008255	COG3906	Belongs to the UPF0473 family
GFX43_008260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFX43_008280	COG0572	uridine kinase
GFX43_008285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFX43_008290	COG0768	penicillin binding
GFX43_008305	COG2226	methyltransferase
GFX43_008310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GFX43_008315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFX43_008320	COG0626	cystathionine gamma-synthase activity
GFX43_008330	COG2427	Protein of unknown function (DUF1641)
GFX43_008335	COG3383	formate dehydrogenase (NAD+) activity
GFX43_008340	COG5609	conserved protein (DUF2294)
GFX43_008345	COG2116	formate transmembrane transporter activity
GFX43_008360	COG2226	methyltransferase
GFX43_008365	COG1309	transcriptional regulator
GFX43_008370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GFX43_008370	COG2124	cytochrome p450
GFX43_008380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFX43_008380	COG2755	lipolytic protein G-D-S-L family
GFX43_008390	COG1595	DNA-templated transcription, initiation
GFX43_008395	COG1378	Sugar-specific transcriptional regulator TrmB
GFX43_008400	COG1280	lysine exporter protein (LysE YggA)
GFX43_008405	COG1113	amino acid transport
GFX43_008415	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GFX43_008415	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GFX43_008420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFX43_008425	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_008430	COG3715	PTS system
GFX43_008435	COG3716	PTS system mannose fructose sorbose family IID component
GFX43_008440	COG1621	beta-fructofuranosidase activity
GFX43_008445	COG0693	protein deglycase activity
GFX43_008450	COG1064	alcohol dehydrogenase
GFX43_008460	COG0789	Transcriptional regulator
GFX43_008465	COG5577	PFAM Coat F domain
GFX43_008475	COG1063	alcohol dehydrogenase
GFX43_008480	COG5577	PFAM Coat F domain
GFX43_008490	COG0346	lactoylglutathione lyase activity
GFX43_008500	COG4991	sh3 domain protein
GFX43_008505	COG4991	sh3 domain protein
GFX43_008510	COG0596	Alpha beta hydrolase
GFX43_008515	COG5566	PFAM Mor transcription activator
GFX43_008520	COG3409	Peptidoglycan-binding domain 1 protein
GFX43_008525	COG0667	Aldo Keto reductase
GFX43_008530	COG1595	DNA-templated transcription, initiation
GFX43_008535	COG3443	Belongs to the bacterial solute-binding protein 9 family
GFX43_008555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFX43_008560	COG2070	2-Nitropropane dioxygenase
GFX43_008570	COG2318	DinB family
GFX43_008585	COG1335	isochorismatase
GFX43_008595	COG2124	cytochrome p450
GFX43_008605	COG1522	sequence-specific DNA binding
GFX43_008610	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GFX43_008615	COG1687	branched-chain amino acid
GFX43_008620	COG1114	Component of the transport system for branched-chain amino acids
GFX43_008635	COG0583	DNA-binding transcription factor activity
GFX43_008640	COG1942	4-Oxalocrotonate Tautomerase
GFX43_008645	COG1230	cation diffusion facilitator family transporter
GFX43_008650	COG2072	flavoprotein involved in K transport
GFX43_008655	COG0583	DNA-binding transcription factor activity
GFX43_008660	COG0697	spore germination
GFX43_008670	COG1253	flavin adenine dinucleotide binding
GFX43_008675	COG0456	acetyltransferase
GFX43_008680	COG2814	Major facilitator Superfamily
GFX43_008685	COG0789	Transcriptional regulator
GFX43_008685	COG4978	Transcriptional regulator
GFX43_008710	COG5444	nuclease activity
GFX43_008715	COG0457	Tetratricopeptide repeat
GFX43_008725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFX43_008730	COG1846	Transcriptional regulator
GFX43_008740	COG2249	NAD(P)H dehydrogenase (quinone) activity
GFX43_008765	COG0563	adenylate kinase activity
GFX43_008780	COG4824	toxin secretion phage lysis holin
GFX43_008810	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_008815	COG1733	regulation of RNA biosynthetic process
GFX43_008820	COG0454	-acetyltransferase
GFX43_008825	COG2311	Membrane
GFX43_008830	COG0745	RESPONSE REGULATOR receiver
GFX43_008835	COG0642	Histidine kinase
GFX43_008835	COG5002	protein histidine kinase activity
GFX43_008840	COG3223	Belongs to the PsiE family
GFX43_008850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GFX43_008860	COG3209	COG3209 Rhs family protein
GFX43_008870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GFX43_008875	COG0398	Pfam SNARE associated Golgi protein
GFX43_008880	COG5632	N-Acetylmuramoyl-L-alanine amidase
GFX43_008880	COG3409	Peptidoglycan-binding domain 1 protein
GFX43_008885	COG2755	lipolytic protein G-D-S-L family
GFX43_008895	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GFX43_008900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFX43_008905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFX43_008910	COG1534	Rna-binding protein
GFX43_008915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFX43_008920	COG1713	HD superfamily hydrolase involved in NAD metabolism
GFX43_008925	COG0799	negative regulation of ribosome biogenesis
GFX43_008930	COG2226	methyltransferase
GFX43_008935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFX43_008940	COG1555	photosystem II stabilization
GFX43_008940	COG1596	polysaccharide export
GFX43_008945	COG2131	deaminase
GFX43_008950	COG2333	competence protein COMEC
GFX43_008950	COG0658	competence protein
GFX43_008965	COG1466	dna polymerase III delta subunit
GFX43_008970	COG0268	Binds directly to 16S ribosomal RNA
GFX43_008975	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GFX43_008980	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFX43_008990	COG0481	GTPase activity
GFX43_008995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFX43_009000	COG1420	regulation of RNA biosynthetic process
GFX43_009005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFX43_009010	COG0443	Heat shock 70 kDa protein
GFX43_009015	COG0484	heat shock protein binding
GFX43_009020	COG2264	protein methyltransferase activity
GFX43_009025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GFX43_009030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFX43_009035	COG1283	sodium-dependent phosphate transmembrane transporter activity
GFX43_009040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFX43_009045	COG1610	YqeY-like protein
GFX43_009050	COG1030	water channel activity
GFX43_009055	COG4864	UPF0365 protein
GFX43_009070	COG0561	phosphatase activity
GFX43_009075	COG1702	phosphate starvation-inducible protein PhoH
GFX43_009080	COG1480	7TM receptor with intracellular HD hydrolase
GFX43_009085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFX43_009090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GFX43_009095	COG0295	cytidine deaminase activity
GFX43_009100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFX43_009110	COG1381	Involved in DNA repair and RecF pathway recombination
GFX43_009115	COG0752	glycyl-tRNA synthetase alpha subunit
GFX43_009120	COG0751	glycine-tRNA ligase activity
GFX43_009125	COG0517	IMP dehydrogenase activity
GFX43_009130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GFX43_009135	COG1671	Belongs to the UPF0178 family
GFX43_009140	COG0358	DNA primase activity
GFX43_009145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFX43_009150	COG2010	Cytochrome c
GFX43_009155	COG2384	SAM-dependent methyltransferase
GFX43_009160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFX43_009165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GFX43_009175	COG0513	Belongs to the DEAD box helicase family
GFX43_009180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GFX43_009190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFX43_009195	COG0735	belongs to the Fur family
GFX43_009200	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GFX43_009205	COG4709	membrane
GFX43_009210	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GFX43_009215	COG1388	LysM domain
GFX43_009220	COG5521	maltodextrose utilization protein MalA
GFX43_009225	COG2839	Protein conserved in bacteria
GFX43_009230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GFX43_009235	COG0477	Major facilitator Superfamily
GFX43_009245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GFX43_009250	COG0573	inorganic phosphate transmembrane transporter activity
GFX43_009255	COG0581	inorganic phosphate transmembrane transporter activity
GFX43_009260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFX43_009265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFX43_009270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFX43_009285	COG0438	transferase activity, transferring glycosyl groups
GFX43_009290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFX43_009295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFX43_009305	COG0705	Rhomboid family
GFX43_009305	COG0457	Tetratricopeptide repeat
GFX43_009310	COG4483	Protein conserved in bacteria
GFX43_009315	COG1940	carbohydrate kinase activity
GFX43_009320	COG1368	sulfuric ester hydrolase activity
GFX43_009325	COG2866	Carboxypeptidase
GFX43_009335	COG0011	TIGRFAM Protein of
GFX43_009345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFX43_009355	COG1393	Belongs to the ArsC family
GFX43_009365	COG1366	Belongs to the anti-sigma-factor antagonist family
GFX43_009370	COG1253	flavin adenine dinucleotide binding
GFX43_009375	COG0598	Magnesium transport protein CorA
GFX43_009380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFX43_009385	COG1459	type II secretion system
GFX43_009390	COG4537	Required for transformation and DNA binding
GFX43_009395	COG4970	Tfp pilus assembly protein FimT
GFX43_009405	COG4940	Competence protein ComGF
GFX43_009430	COG0681	Belongs to the peptidase S26 family
GFX43_009440	COG1396	sequence-specific DNA binding
GFX43_009455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFX43_009460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFX43_009465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFX43_009470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFX43_009475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFX43_009480	COG0095	Lipoate-protein ligase
GFX43_009485	COG1321	iron dependent repressor
GFX43_009490	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFX43_009500	COG3872	metal-dependent enzyme
GFX43_009510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GFX43_009515	COG0006	proline dipeptidase activity
GFX43_009520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFX43_009530	COG3854	ATPases associated with a variety of cellular activities
GFX43_009570	COG0511	ligase activity, forming carbon-carbon bonds
GFX43_009575	COG0439	Biotin carboxylase
GFX43_009580	COG1302	Protein conserved in bacteria
GFX43_009585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFX43_009590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFX43_009595	COG1570	exodeoxyribonuclease VII activity
GFX43_009600	COG1722	exodeoxyribonuclease VII activity
GFX43_009605	COG0142	geranyltranstransferase activity
GFX43_009610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFX43_009615	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GFX43_009620	COG1438	arginine binding
GFX43_009625	COG0497	DNA recombination
GFX43_009630	COG0750	zinc metalloprotease
GFX43_009635	COG0745	RESPONSE REGULATOR receiver
GFX43_009640	COG1902	pentaerythritol trinitrate reductase activity
GFX43_009655	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFX43_009660	COG0584	glycerophosphoryl diester phosphodiesterase
GFX43_009665	COG0183	Belongs to the thiolase family
GFX43_009670	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFX43_009675	COG1960	acyl-CoA dehydrogenase activity
GFX43_009680	COG0372	Belongs to the citrate synthase family
GFX43_009685	COG2079	MmgE PrpD family protein
GFX43_009690	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GFX43_009700	COG3829	transcription factor binding
GFX43_009700	COG3290	protein histidine kinase activity
GFX43_009705	COG0280	phosphate acetyltransferase
GFX43_009710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFX43_009715	COG3426	butyrate kinase activity
GFX43_009720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFX43_009725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFX43_009730	COG0022	dehydrogenase e1 component
GFX43_009735	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFX43_009740	COG4978	Transcriptional regulator
GFX43_009740	COG0789	Transcriptional regulator
GFX43_009745	COG2814	Major facilitator Superfamily
GFX43_009750	COG1597	lipid kinase activity
GFX43_009760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFX43_009765	COG0765	amino acid transport
GFX43_009770	COG1126	abc transporter atp-binding protein
GFX43_009775	COG4129	membrane
GFX43_009780	COG1376	ErfK ybiS ycfS ynhG family protein
GFX43_009790	COG0346	lactoylglutathione lyase activity
GFX43_009795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFX43_009800	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFX43_009805	COG3361	conserved protein (COG2071)
GFX43_009810	COG0706	membrane insertase activity
GFX43_009820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFX43_009825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GFX43_009830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GFX43_009835	COG1234	tRNA 3'-trailer cleavage
GFX43_009845	COG0596	Alpha beta hydrolase
GFX43_009850	COG1902	pentaerythritol trinitrate reductase activity
GFX43_009855	COG4187	Peptidase family M20/M25/M40
GFX43_009860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFX43_009865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFX43_009870	COG0300	oxidoreductase activity
GFX43_009875	COG3048	D-serine ammonia-lyase activity
GFX43_009880	COG1072	(Pantothenic acid kinase))
GFX43_009885	COG0346	lactoylglutathione lyase activity
GFX43_009890	COG2211	Major facilitator Superfamily
GFX43_009900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFX43_009910	COG0456	acetyltransferase
GFX43_009915	COG2329	Antibiotic biosynthesis monooxygenase
GFX43_009920	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GFX43_009920	COG0456	acetyltransferase
GFX43_009925	COG4918	Iron-sulphur cluster biosynthesis
GFX43_009935	COG1073	alpha beta
GFX43_009945	COG0667	Aldo Keto reductase
GFX43_009955	COG0494	nUDIX hydrolase
GFX43_009960	COG1379	DNA repair
GFX43_009965	COG1396	sequence-specific DNA binding
GFX43_009970	COG0252	asparaginase activity
GFX43_009975	COG1027	Aspartate ammonia-lyase
GFX43_009980	COG1757	Na H antiporter
GFX43_009985	COG0281	malic enzyme
GFX43_009995	COG1300	Membrane
GFX43_010000	COG0735	belongs to the Fur family
GFX43_010010	COG4974	Belongs to the 'phage' integrase family
GFX43_010015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GFX43_010020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GFX43_010025	COG1686	Belongs to the peptidase S11 family
GFX43_010030	COG1366	Belongs to the anti-sigma-factor antagonist family
GFX43_010035	COG2172	sigma factor antagonist activity
GFX43_010040	COG1191	sigma factor activity
GFX43_010060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFX43_010075	COG0697	spore germination
GFX43_010080	COG0019	diaminopimelate decarboxylase activity
GFX43_010085	COG4086	secreted protein
GFX43_010090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFX43_010100	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GFX43_010110	COG0681	Belongs to the peptidase S26 family
GFX43_010120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFX43_010120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFX43_010125	COG0307	riboflavin synthase, alpha
GFX43_010130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFX43_010130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFX43_010135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFX43_010140	COG0456	acetyltransferase
GFX43_010145	COG1547	Domain of unknown function (DUF309)
GFX43_010150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GFX43_010155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GFX43_010165	COG1686	Belongs to the peptidase S11 family
GFX43_010170	COG2715	membrane protein required for spore maturation
GFX43_010175	COG0700	Nucleoside recognition
GFX43_010180	COG1187	pseudouridine synthase activity
GFX43_010185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFX43_010190	COG1333	cytochrome c biogenesis protein
GFX43_010195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFX43_010200	COG0745	RESPONSE REGULATOR receiver
GFX43_010205	COG5002	protein histidine kinase activity
GFX43_010210	COG1595	DNA-templated transcription, initiation
GFX43_010220	COG0710	3-dehydroquinate dehydratase activity
GFX43_010225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFX43_010230	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GFX43_010235	COG1141	Ferredoxin
GFX43_010240	COG4955	Helix-turn-helix domain
GFX43_010245	COG0514	ATP-dependent DNA helicase (RecQ)
GFX43_010250	COG1266	CAAX protease self-immunity
GFX43_010255	COG1388	LysM domain
GFX43_010265	COG1408	metallophosphoesterase
GFX43_010270	COG4862	establishment of competence for transformation
GFX43_010275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFX43_010280	COG0492	ferredoxin-NADP+ reductase activity
GFX43_010285	COG2339	peptidase activity
GFX43_010290	COG3773	Cell wall hydrolase
GFX43_010290	COG3409	Peptidoglycan-binding domain 1 protein
GFX43_010295	COG2959	enzyme of heme biosynthesis
GFX43_010300	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GFX43_010310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GFX43_010315	COG0539	negative regulation of cytoplasmic translation
GFX43_010320	COG1304	FMN binding
GFX43_010345	COG1160	GTP binding
GFX43_010350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFX43_010365	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GFX43_010370	COG0776	regulation of translation
GFX43_010375	COG0302	gtp cyclohydrolase
GFX43_010385	COG0142	geranyltranstransferase activity
GFX43_010390	COG2226	methyltransferase
GFX43_010395	COG0142	geranyltranstransferase activity
GFX43_010400	COG0105	UTP biosynthetic process
GFX43_010405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GFX43_010410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFX43_010415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFX43_010420	COG4401	Chorismate mutase type I
GFX43_010425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFX43_010430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFX43_010440	COG0135	phosphoribosylanthranilate isomerase activity
GFX43_010445	COG0133	tryptophan synthase activity
GFX43_010450	COG0159	tryptophan synthase activity
GFX43_010455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFX43_010460	COG0287	Prephenate dehydrogenase
GFX43_010465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GFX43_010470	COG0457	Tetratricopeptide repeat
GFX43_010475	COG5582	Belongs to the UPF0302 family
GFX43_010485	COG0723	plastoquinol--plastocyanin reductase activity
GFX43_010490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFX43_010495	COG2010	Cytochrome c
GFX43_010495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFX43_010500	COG4347	Protein of unknown function (DUF1405)
GFX43_010510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFX43_010515	COG1694	Mazg nucleotide pyrophosphohydrolase
GFX43_010520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFX43_010525	COG1803	Methylglyoxal synthase
GFX43_010530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFX43_010535	COG0438	transferase activity, transferring glycosyl groups
GFX43_010540	COG0617	tRNA 3'-terminal CCA addition
GFX43_010545	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GFX43_010545	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GFX43_010550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFX43_010555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GFX43_010560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GFX43_010565	COG1199	ATP-dependent helicase activity
GFX43_010565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFX43_010575	COG5353	protein conserved in bacteria
GFX43_010580	COG0436	Aminotransferase
GFX43_010585	COG0017	Asparaginyl-tRNA synthetase
GFX43_010590	COG3935	DnaD domain protein
GFX43_010595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFX43_010605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFX43_010605	COG4499	WXG100 protein secretion system (Wss), protein YukC
GFX43_010610	COG3331	DNA recombination
GFX43_010645	COG0071	Belongs to the small heat shock protein (HSP20) family
GFX43_010650	COG2190	(PTS) system
GFX43_010655	COG1205	dead DEAH box helicase
GFX43_010655	COG1111	helicase
GFX43_010660	COG3359	exonuclease
GFX43_010675	COG4474	Belongs to the UPF0398 family
GFX43_010690	COG0116	Belongs to the methyltransferase superfamily
GFX43_010705	COG1199	ATP-dependent helicase activity
GFX43_010710	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_010715	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GFX43_010720	COG1609	Transcriptional regulator
GFX43_010725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFX43_010730	COG0800	Aldolase
GFX43_010740	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GFX43_010745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFX43_010750	COG2233	PERMEase
GFX43_010755	COG3424	synthase
GFX43_010760	COG1755	Isoprenylcysteine carboxyl methyltransferase
GFX43_010770	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GFX43_010785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFX43_010795	COG0328	RNA-DNA hybrid ribonuclease activity
GFX43_010800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GFX43_010805	COG0328	RNA-DNA hybrid ribonuclease activity
GFX43_010825	COG1278	Cold shock
GFX43_010835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFX43_010840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GFX43_010845	COG0386	Belongs to the glutathione peroxidase family
GFX43_010850	COG1418	mRNA catabolic process
GFX43_010855	COG1413	lyase activity
GFX43_010865	COG0129	dihydroxy-acid dehydratase activity
GFX43_010875	COG2521	methyltransferase
GFX43_010875	COG2136	Putative SAM-dependent methyltransferase
GFX43_010885	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GFX43_010890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GFX43_010895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFX43_010900	COG0204	Acyl-transferase
GFX43_010905	COG1272	protein, Hemolysin III
GFX43_010910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GFX43_010915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFX43_010925	COG1999	signal sequence binding
GFX43_010930	COG2755	lipolytic protein G-D-S-L family
GFX43_010935	COG4698	Protein conserved in bacteria
GFX43_010945	COG0534	Mate efflux family protein
GFX43_010950	COG1846	Transcriptional regulator
GFX43_010955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFX43_010960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFX43_010965	COG1086	Polysaccharide biosynthesis protein
GFX43_010970	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GFX43_010975	COG4641	Protein conserved in bacteria
GFX43_010990	COG0463	Glycosyl transferase, family 2
GFX43_010995	COG0456	acetyltransferase
GFX43_011010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFX43_011015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GFX43_011020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GFX43_011025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFX43_011030	COG0456	acetyltransferase
GFX43_011035	COG1509	lysine 2,3-aminomutase activity
GFX43_011045	COG4479	Belongs to the UPF0346 family
GFX43_011065	COG0671	phosphoesterase, PA-phosphatase related
GFX43_011080	COG0813	purine-nucleoside phosphorylase activity
GFX43_011085	COG1876	peptidase activity
GFX43_011095	COG2226	methyltransferase
GFX43_011100	COG0793	Belongs to the peptidase S41A family
GFX43_011100	COG3409	Peptidoglycan-binding domain 1 protein
GFX43_011105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFX43_011115	COG0346	lactoylglutathione lyase activity
GFX43_011120	COG0400	carboxylic ester hydrolase activity
GFX43_011125	COG0778	Nitroreductase
GFX43_011130	COG1733	regulation of RNA biosynthetic process
GFX43_011135	COG1942	4-Oxalocrotonate Tautomerase
GFX43_011140	COG2610	gluconate transmembrane transporter activity
GFX43_011155	COG2962	Rard protein
GFX43_011165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFX43_011170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFX43_011175	COG1366	Belongs to the anti-sigma-factor antagonist family
GFX43_011180	COG0534	Mate efflux family protein
GFX43_011185	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GFX43_011190	COG1819	glycosyl
GFX43_011195	COG0791	NLP P60 protein
GFX43_011195	COG1388	LysM domain
GFX43_011200	COG2032	superoxide dismutase activity
GFX43_011205	COG0714	Associated with various cellular activities
GFX43_011210	COG4548	von Willebrand factor, type A
GFX43_011215	COG0567	Dehydrogenase, E1 component
GFX43_011220	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFX43_011225	COG0385	Bile acid
GFX43_011230	COG0733	neurotransmitter:sodium symporter activity
GFX43_011235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GFX43_011240	COG1657	PFAM Prenyltransferase squalene oxidase
GFX43_011245	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_011270	COG0071	Belongs to the small heat shock protein (HSP20) family
GFX43_011285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GFX43_011290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GFX43_011300	COG0514	ATP-dependent DNA helicase (RecQ)
GFX43_011305	COG1388	LysM domain
GFX43_011305	COG3584	3D domain protein
GFX43_011310	COG2197	response regulator
GFX43_011315	COG4585	Histidine kinase
GFX43_011320	COG3239	Fatty acid desaturase
GFX43_011325	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFX43_011340	COG2322	membrane
GFX43_011345	COG0741	lytic transglycosylase activity
GFX43_011350	COG0640	Transcriptional regulator
GFX43_011360	COG2378	regulation of single-species biofilm formation
GFX43_011365	COG3708	Transcriptional regulator
GFX43_011370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFX43_011375	COG1309	transcriptional regulator
GFX43_011380	COG2207	Transcriptional regulator
GFX43_011380	COG0662	Cupin 2, conserved barrel domain protein
GFX43_011385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFX43_011390	COG1231	oxidoreductase activity
GFX43_011395	COG4282	regulation of fungal-type cell wall biogenesis
GFX43_011400	COG5444	nuclease activity
GFX43_011440	COG1793	dna ligase
GFX43_011445	COG0726	polysaccharide deacetylase
GFX43_011450	COG3848	Pyruvate phosphate dikinase
GFX43_011450	COG0574	Belongs to the PEP-utilizing enzyme family
GFX43_011465	COG2367	Beta-lactamase
GFX43_011470	COG0693	protein deglycase activity
GFX43_011480	COG0697	spore germination
GFX43_011485	COG0583	DNA-binding transcription factor activity
GFX43_011490	COG3739	integral membrane protein
GFX43_011505	COG2720	vancomycin resistance protein
GFX43_011530	COG2140	Oxalate decarboxylase
GFX43_011545	COG3866	Pectate lyase
GFX43_011550	COG3619	membrane
GFX43_011555	COG4305	rare lipoprotein A
GFX43_011560	COG2368	4-hydroxyphenylacetate
GFX43_011565	COG5278	phosphoserine phosphatase activity
GFX43_011565	COG0840	transmembrane signaling receptor activity
GFX43_011590	COG0243	molybdopterin cofactor binding
GFX43_011595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFX43_011600	COG1070	Carbohydrate kinase
GFX43_011605	COG2814	Major facilitator Superfamily
GFX43_011610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFX43_011620	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GFX43_011625	COG0300	oxidoreductase activity
GFX43_011635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFX43_011640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFX43_011645	COG0583	DNA-binding transcription factor activity
GFX43_011650	COG0069	glutamate synthase activity
GFX43_011650	COG0070	glutamate synthase
GFX43_011650	COG0067	glutamate synthase
GFX43_011655	COG0493	'glutamate synthase
GFX43_011660	COG0604	alcohol dehydrogenase
GFX43_011665	COG0583	DNA-binding transcription factor activity
GFX43_011670	COG0405	Gamma-glutamyltransferase
GFX43_011675	COG0166	Belongs to the GPI family
GFX43_011680	COG0582	viral genome integration into host DNA
GFX43_011695	COG0534	Mate efflux family protein
GFX43_011700	COG2017	converts alpha-aldose to the beta-anomer
GFX43_011705	COG2027	D-alanyl-D-alanine carboxypeptidase
GFX43_011710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_011715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_011720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_011725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_011730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_011730	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GFX43_011740	COG1649	PFAM Uncharacterised BCR, COG1649
GFX43_011755	COG1960	acyl-CoA dehydrogenase activity
GFX43_011760	COG0318	PFAM AMP-dependent synthetase and ligase
GFX43_011765	COG0439	Biotin carboxylase
GFX43_011770	COG0511	ligase activity, forming carbon-carbon bonds
GFX43_011775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFX43_011780	COG1024	Enoyl-CoA hydratase
GFX43_011785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFX43_011790	COG2404	hydrolase activity, acting on ester bonds
GFX43_011795	COG0586	Pfam SNARE associated Golgi protein
GFX43_011800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GFX43_011805	COG2246	polysaccharide biosynthetic process
GFX43_011810	COG3507	Belongs to the glycosyl hydrolase 43 family
GFX43_011815	COG5520	Belongs to the glycosyl hydrolase 30 family
GFX43_011830	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GFX43_011835	COG1115	amino acid carrier protein
GFX43_011845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFX43_011850	COG0187	DNA topoisomerase II activity
GFX43_011855	COG1832	CoA-binding protein
GFX43_011860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GFX43_011865	COG4841	protein insertion into membrane
GFX43_011875	COG0824	Thioesterase
GFX43_011895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFX43_011900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFX43_011915	COG0071	Belongs to the small heat shock protein (HSP20) family
GFX43_011925	COG4846	Membrane protein involved in cytochrome C biogenesis
GFX43_011930	COG2201	protein-glutamate methylesterase activity
GFX43_011935	COG0785	Cytochrome C biogenesis protein
GFX43_011945	COG3763	UPF0154 protein
GFX43_011955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GFX43_011960	COG4224	UPF0291 protein
GFX43_011965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GFX43_011970	COG1388	LysM domain
GFX43_011975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GFX43_011980	COG0346	lactoylglutathione lyase activity
GFX43_011990	COG4195	phage-related replication protein
GFX43_012020	COG0531	amino acid
GFX43_012025	COG0697	spore germination
GFX43_012035	COG3832	glyoxalase III activity
GFX43_012045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFX43_012075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GFX43_012090	COG0756	dUTP diphosphatase activity
GFX43_012100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFX43_012105	COG2814	Major facilitator Superfamily
GFX43_012110	COG1525	nuclease
GFX43_012120	COG1070	Carbohydrate kinase
GFX43_012125	COG2115	Belongs to the xylose isomerase family
GFX43_012130	COG1940	carbohydrate kinase activity
GFX43_012135	COG3507	Belongs to the glycosyl hydrolase 43 family
GFX43_012140	COG2211	Major facilitator Superfamily
GFX43_012170	COG3655	Transcriptional regulator
GFX43_012185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFX43_012195	COG4282	regulation of fungal-type cell wall biogenesis
GFX43_012240	COG0174	glutamine synthetase
GFX43_012245	COG0789	Transcriptional regulator
GFX43_012250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GFX43_012255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFX43_012260	COG0464	growth
GFX43_012265	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFX43_012270	COG4112	unkown
GFX43_012275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFX43_012280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFX43_012285	COG1780	Probably involved in ribonucleotide reductase function
GFX43_012300	COG1923	regulation of RNA biosynthetic process
GFX43_012305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFX43_012320	COG2076	Multidrug Resistance protein
GFX43_012325	COG2076	Multidrug Resistance protein
GFX43_012330	COG1764	response to oxidative stress
GFX43_012335	COG4195	phage-related replication protein
GFX43_012345	COG1404	Belongs to the peptidase S8 family
GFX43_012350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFX43_012360	COG2124	cytochrome p450
GFX43_012365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFX43_012365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFX43_012365	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GFX43_012365	COG3321	synthase
GFX43_012370	COG3321	synthase
GFX43_012370	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_012370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_012370	COG4221	oxidoreductase activity
GFX43_012375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFX43_012375	COG3321	synthase
GFX43_012375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFX43_012375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_012375	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_012380	COG3321	synthase
GFX43_012380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFX43_012380	COG4221	oxidoreductase activity
GFX43_012380	COG0300	oxidoreductase activity
GFX43_012385	COG0318	PFAM AMP-dependent synthetase and ligase
GFX43_012385	COG0300	oxidoreductase activity
GFX43_012385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_012385	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_012385	COG3321	synthase
GFX43_012390	COG1024	Enoyl-CoA hydratase
GFX43_012395	COG1024	Enoyl-CoA hydratase
GFX43_012400	COG3425	synthase
GFX43_012405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFX43_012410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFX43_012415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFX43_012415	COG2070	2-Nitropropane dioxygenase
GFX43_012420	COG3321	synthase
GFX43_012425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFX43_012435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFX43_012440	COG3226	Transcriptional regulator
GFX43_012455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFX43_012460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFX43_012470	COG4550	Control of competence regulator ComK, YlbF/YmcA
GFX43_012475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFX43_012480	COG0156	8-amino-7-oxononanoate synthase activity
GFX43_012485	COG1063	alcohol dehydrogenase
GFX43_012490	COG2359	stage V sporulation protein S
GFX43_012495	COG1692	metallophosphoesterase
GFX43_012500	COG1418	mRNA catabolic process
GFX43_012505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFX43_012510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFX43_012515	COG1058	Belongs to the CinA family
GFX43_012515	COG1546	Belongs to the CinA family
GFX43_012520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFX43_012525	COG1426	Protein conserved in bacteria
GFX43_012540	COG0300	oxidoreductase activity
GFX43_012545	COG0612	Peptidase, M16
GFX43_012550	COG0612	Peptidase, M16
GFX43_012555	COG2814	Major facilitator Superfamily
GFX43_012560	COG2188	Transcriptional regulator
GFX43_012565	COG4980	gas vesicle protein
GFX43_012565	COG1674	ftsk spoiiie
GFX43_012575	COG0740	serine-type endopeptidase activity
GFX43_012580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFX43_012585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFX43_012590	COG0527	aspartate kinase activity
GFX43_012595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GFX43_012600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFX43_012605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFX43_012610	COG1873	PFAM PRC-barrel domain
GFX43_012615	COG0612	Peptidase, M16
GFX43_012620	COG0726	polysaccharide deacetylase
GFX43_012625	COG1185	polyribonucleotide nucleotidyltransferase activity
GFX43_012630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFX43_012635	COG0196	riboflavin kinase activity
GFX43_012640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFX43_012645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFX43_012650	COG1550	Protein conserved in bacteria
GFX43_012655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFX43_012660	COG1358	cellular component organization or biogenesis
GFX43_012665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GFX43_012670	COG0195	Participates in both transcription termination and antitermination
GFX43_012675	COG0779	Required for maturation of 30S ribosomal subunits
GFX43_012680	COG2176	DNA-directed DNA polymerase activity
GFX43_012685	COG0442	prolyl-tRNA aminoacylation
GFX43_012690	COG0750	zinc metalloprotease
GFX43_012695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GFX43_012700	COG4589	Belongs to the CDS family
GFX43_012705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFX43_012710	COG0233	cytoplasmic translational termination
GFX43_012715	COG0528	UMP kinase activity
GFX43_012720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GFX43_012725	COG0052	Belongs to the universal ribosomal protein uS2 family
GFX43_012735	COG1191	sigma factor activity
GFX43_012740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GFX43_012745	COG1776	CheC inhibitor of MCP methylation
GFX43_012750	COG0835	chemotaxis
GFX43_012755	COG0643	Histidine kinase
GFX43_012755	COG2198	Histidine kinase
GFX43_012760	COG2201	protein-glutamate methylesterase activity
GFX43_012765	COG0455	bacterial-type flagellum organization
GFX43_012770	COG1419	protein localization to endoplasmic reticulum
GFX43_012775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GFX43_012780	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GFX43_012785	COG1684	flagellar biosynthetic protein fliR
GFX43_012790	COG1987	bacterial-type flagellum assembly
GFX43_012795	COG1338	Plays a role in the flagellum-specific transport system
GFX43_012800	COG3190	flagellar
GFX43_012805	COG2201	protein-glutamate methylesterase activity
GFX43_012810	COG1776	CheC inhibitor of MCP methylation
GFX43_012810	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GFX43_012815	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GFX43_012820	COG1580	Controls the rotational direction of flagella during chemotaxis
GFX43_012825	COG1582	Flagellar protein (FlbD)
GFX43_012830	COG4786	Flagellar basal body rod
GFX43_012835	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GFX43_012840	COG3144	bacterial-type flagellum assembly
GFX43_012845	COG3334	PFAM MgtE intracellular
GFX43_012850	COG2882	bacterial-type flagellum organization
GFX43_012855	COG1157	protein secretion by the type III secretion system
GFX43_012860	COG1317	bacterial-type flagellum organization
GFX43_012865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GFX43_012870	COG1766	The M ring may be actively involved in energy transduction
GFX43_012875	COG1677	Flagellar hook-basal body complex protein FliE
GFX43_012880	COG1558	bacterial-type flagellum-dependent cell motility
GFX43_012885	COG1815	bacterial-type flagellum-dependent cell motility
GFX43_012890	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GFX43_012895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GFX43_012900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GFX43_012905	COG4974	Belongs to the 'phage' integrase family
GFX43_012910	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GFX43_012915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFX43_012925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GFX43_012930	COG0045	succinate-CoA ligase (ADP-forming) activity
GFX43_012935	COG2257	FlhB HrpN YscU SpaS Family
GFX43_012945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFX43_012950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFX43_012955	COG0335	large ribosomal subunit rRNA binding
GFX43_012960	COG0336	Belongs to the RNA methyltransferase TrmD family
GFX43_012965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFX43_012975	COG1837	Belongs to the UPF0109 family
GFX43_012980	COG0228	four-way junction DNA binding
GFX43_012985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFX43_012990	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GFX43_013000	COG0552	protein localization to endoplasmic reticulum
GFX43_013005	COG1196	nuclear chromosome segregation
GFX43_013010	COG0571	ribonuclease III activity
GFX43_013015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFX43_013020	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_013025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFX43_013030	COG0416	fatty acid biosynthetic process
GFX43_013035	COG2050	protein possibly involved in aromatic compounds catabolism
GFX43_013035	COG1349	DNA-binding transcription factor activity
GFX43_013040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFX43_013045	COG1760	l-serine dehydratase
GFX43_013050	COG1760	l-serine dehydratase
GFX43_013055	COG1461	Dihydroxyacetone kinase
GFX43_013060	COG1302	Protein conserved in bacteria
GFX43_013065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFX43_013075	COG1564	THIamine pyrophosphokinase
GFX43_013080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFX43_013085	COG1162	GTPase activity
GFX43_013090	COG0515	serine threonine protein kinase
GFX43_013090	COG2815	serine threonine protein kinase
GFX43_013095	COG0631	protein serine/threonine phosphatase activity
GFX43_013100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GFX43_013105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFX43_013105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFX43_013110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFX43_013115	COG0242	peptide deformylase activity
GFX43_013120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFX43_013125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFX43_013130	COG1758	RNA polymerase activity
GFX43_013135	COG0194	GDP metabolic process
GFX43_013140	COG2052	Domain of unknown function (DUF370)
GFX43_013145	COG1561	YicC-like family, N-terminal region
GFX43_013150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFX43_013160	COG1648	precorrin-2 dehydrogenase activity
GFX43_013165	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GFX43_013170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFX43_013175	COG0529	Catalyzes the synthesis of activated sulfate
GFX43_013180	COG2046	Belongs to the sulfate adenylyltransferase family
GFX43_013185	COG0306	phosphate transporter
GFX43_013190	COG0175	sulfate reduction
GFX43_013195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFX43_013200	COG0284	orotidine-5'-phosphate decarboxylase activity
GFX43_013205	COG0167	dihydroorotate dehydrogenase activity
GFX43_013210	COG0543	2 iron, 2 sulfur cluster binding
GFX43_013215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GFX43_013220	COG0505	Belongs to the CarA family
GFX43_013225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFX43_013230	COG0540	Belongs to the ATCase OTCase family
GFX43_013235	COG2233	PERMEase
GFX43_013240	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GFX43_013245	COG0564	pseudouridine synthase activity
GFX43_013250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFX43_013255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GFX43_013260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFX43_013265	COG3599	regulation of cell shape
GFX43_013270	COG2302	S4 RNA-binding domain
GFX43_013275	COG0762	integral membrane protein
GFX43_013280	COG1799	cell septum assembly
GFX43_013285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFX43_013295	COG1873	PFAM PRC-barrel domain
GFX43_013300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFX43_013305	COG1119	ATPase activity
GFX43_013310	COG1191	sigma factor activity
GFX43_013315	COG1191	sigma factor activity
GFX43_013325	COG1404	Belongs to the peptidase S8 family
GFX43_013325	COG4412	M6 family metalloprotease domain protein
GFX43_013330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFX43_013335	COG0849	cell division
GFX43_013340	COG3856	small basic protein
GFX43_013345	COG3879	Bacterial protein of unknown function (DUF881)
GFX43_013350	COG3879	Bacterial protein of unknown function (DUF881)
GFX43_013355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GFX43_013360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFX43_013365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFX43_013370	COG0772	Belongs to the SEDS family
GFX43_013375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFX43_013380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFX43_013385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFX43_013390	COG0768	penicillin binding
GFX43_013400	COG4839	cell division protein FtsL
GFX43_013405	COG0275	rRNA processing
GFX43_013410	COG2001	Belongs to the MraZ family
GFX43_013415	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GFX43_013420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFX43_013425	COG0454	-acetyltransferase
GFX43_013435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GFX43_013440	COG1399	metal-binding, possibly nucleic acid-binding protein
GFX43_013460	COG3480	Lon protease (S16) C-terminal proteolytic domain
GFX43_013465	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFX43_013470	COG3314	Sporulation integral membrane protein YlbJ
GFX43_013475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFX43_013480	COG0742	ribosomal rna small subunit methyltransferase
GFX43_013485	COG4471	UPF0298 protein
GFX43_013490	COG3679	Belongs to the UPF0342 family
GFX43_013505	COG2340	Cysteine-rich secretory protein family
GFX43_013510	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GFX43_013520	COG3336	cytochrome c oxidase
GFX43_013525	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GFX43_013530	COG1845	cytochrome c oxidase, subunit III
GFX43_013535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFX43_013540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GFX43_013540	COG2010	Cytochrome c
GFX43_013545	COG0109	protoheme IX farnesyltransferase activity
GFX43_013550	COG1612	heme a metabolic process
GFX43_013555	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GFX43_013560	COG0772	Belongs to the SEDS family
GFX43_013565	COG4838	Belongs to the UPF0358 family
GFX43_013570	COG2066	Belongs to the glutaminase family
GFX43_013575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFX43_013580	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GFX43_013590	COG4896	Protein conserved in bacteria
GFX43_013620	COG1595	DNA-templated transcription, initiation
GFX43_013640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GFX43_013650	COG0483	inositol monophosphate 1-phosphatase activity
GFX43_013660	COG4493	Belongs to the UPF0637 family
GFX43_013665	COG4476	Belongs to the UPF0223 family
GFX43_013670	COG1982	Orn Lys Arg decarboxylase major
GFX43_013680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFX43_013685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFX43_013690	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFX43_013695	COG0022	dehydrogenase e1 component
GFX43_013700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFX43_013705	COG0497	DNA recombination
GFX43_013715	COG0242	peptide deformylase activity
GFX43_013720	COG0561	phosphatase activity
GFX43_013730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFX43_013735	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GFX43_013740	COG0569	domain protein
GFX43_013745	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GFX43_013745	COG2105	PFAM AIG2 family protein
GFX43_013750	COG3852	Histidine kinase
GFX43_013755	COG2002	toxin-antitoxin pair type II binding
GFX43_013760	COG1077	Cell shape determining protein MreB Mrl
GFX43_013770	COG2309	aminopeptidase activity
GFX43_013780	COG0488	(ABC) transporter
GFX43_013790	COG0681	Belongs to the peptidase S26 family
GFX43_013795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFX43_013795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFX43_013795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFX43_013800	COG1105	Belongs to the carbohydrate kinase PfkB family
GFX43_013805	COG1349	DNA-binding transcription factor activity
GFX43_013810	COG0577	efflux transmembrane transporter activity
GFX43_013815	COG1136	(ABC) transporter
GFX43_013820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFX43_013830	COG1132	(ABC) transporter
GFX43_013835	COG1132	(ABC) transporter
GFX43_013840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GFX43_013845	COG0314	molybdopterin synthase activity
GFX43_013850	COG1763	Mo-molybdopterin cofactor biosynthetic process
GFX43_013855	COG0303	'Molybdopterin
GFX43_013860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFX43_013865	COG0746	molybdenum cofactor guanylyltransferase activity
GFX43_013880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFX43_013885	COG0450	alkyl hydroperoxide reductase
GFX43_013890	COG0668	transmembrane transport
GFX43_013900	COG1473	amidohydrolase
GFX43_013905	COG2171	N-acyltransferase activity
GFX43_013910	COG0716	FMN binding
GFX43_013920	COG0716	FMN binding
GFX43_013925	COG0583	DNA-binding transcription factor activity
GFX43_013930	COG0517	IMP dehydrogenase activity
GFX43_013940	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GFX43_013945	COG4703	Protein of unknown function (DUF1797)
GFX43_013950	COG2200	EAL domain
GFX43_013955	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_013960	COG1408	metallophosphoesterase
GFX43_013965	COG1376	ErfK ybiS ycfS ynhG family protein
GFX43_013970	COG2814	Major facilitator Superfamily
GFX43_013980	COG0835	chemotaxis
GFX43_013980	COG0784	Response regulator, receiver
GFX43_013990	COG0436	Aminotransferase
GFX43_013995	COG4191	Histidine kinase
GFX43_014000	COG0768	penicillin binding
GFX43_014005	COG2340	Cysteine-rich secretory protein family
GFX43_014010	COG2084	Dehydrogenase
GFX43_014015	COG0840	transmembrane signaling receptor activity
GFX43_014020	COG0456	acetyltransferase
GFX43_014025	COG1533	DNA photolyase activity
GFX43_014035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFX43_014040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFX43_014045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_014045	COG2190	(PTS) system
GFX43_014045	COG1263	PTS System
GFX43_014050	COG3711	transcriptional antiterminator
GFX43_014055	COG1609	Transcriptional regulator
GFX43_014060	COG0006	proline dipeptidase activity
GFX43_014070	COG2217	Heavy metal translocating P-type atpase
GFX43_014075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFX43_014080	COG2244	polysaccharide biosynthetic process
GFX43_014085	COG3773	Cell wall hydrolase
GFX43_014095	COG4873	Protein conserved in bacteria
GFX43_014105	COG3858	chitin binding
GFX43_014110	COG1388	LysM domain
GFX43_014115	COG1388	LysM domain
GFX43_014115	COG4641	Protein conserved in bacteria
GFX43_014120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GFX43_014125	COG0602	queuosine metabolic process
GFX43_014130	COG0720	synthase
GFX43_014135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GFX43_014140	COG3949	Membrane
GFX43_014145	COG0542	response to heat
GFX43_014150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GFX43_014155	COG1360	Flagellar Motor Protein
GFX43_014160	COG1846	Transcriptional regulator
GFX43_014165	COG3852	Histidine kinase
GFX43_014180	COG3339	Conserved Protein
GFX43_014185	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GFX43_014190	COG0235	Class ii aldolase
GFX43_014195	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GFX43_014200	COG1850	ribulose-bisphosphate carboxylase activity
GFX43_014205	COG0436	Aminotransferase
GFX43_014210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFX43_014215	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GFX43_014220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GFX43_014230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFX43_014235	COG5002	protein histidine kinase activity
GFX43_014240	COG3594	Acyltransferase
GFX43_014255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFX43_014260	COG0501	Belongs to the peptidase M48B family
GFX43_014280	COG1191	sigma factor activity
GFX43_014285	COG0861	Integral membrane protein TerC family
GFX43_014290	COG0586	Pfam SNARE associated Golgi protein
GFX43_014295	COG5001	Diguanylate cyclase
GFX43_014295	COG3300	MHYT domain
GFX43_014300	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GFX43_014305	COG1793	dna ligase
GFX43_014305	COG3285	dna ligase
GFX43_014310	COG0463	Glycosyl transferase, family 2
GFX43_014320	COG1408	metallophosphoesterase
GFX43_014325	COG0726	polysaccharide deacetylase
GFX43_014330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFX43_014335	COG1846	Transcriptional regulator
GFX43_014350	COG0789	Transcriptional regulator
GFX43_014355	COG2239	Acts as a magnesium transporter
GFX43_014365	COG3212	peptidase
GFX43_014370	COG3212	peptidase
GFX43_014375	COG3850	Histidine kinase
GFX43_014375	COG5002	protein histidine kinase activity
GFX43_014380	COG0745	RESPONSE REGULATOR receiver
GFX43_014390	COG4721	ABC-type cobalt transport system, permease component
GFX43_014395	COG1122	ATPase activity
GFX43_014400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GFX43_014405	COG1366	Belongs to the anti-sigma-factor antagonist family
GFX43_014410	COG1404	Belongs to the peptidase S8 family
GFX43_014415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFX43_014425	COG0590	tRNA wobble adenosine to inosine editing
GFX43_014430	COG1764	response to oxidative stress
GFX43_014435	COG1846	Transcriptional regulator
GFX43_014440	COG1764	response to oxidative stress
GFX43_014445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFX43_014450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFX43_014455	COG0788	formyltetrahydrofolate deformylase activity
GFX43_014460	COG2076	Multidrug Resistance protein
GFX43_014465	COG2076	Multidrug Resistance protein
GFX43_014470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFX43_014475	COG2318	DinB family
GFX43_014480	COG2323	membrane
GFX43_014490	COG1017	nitric oxide dioxygenase activity
GFX43_014490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GFX43_014495	COG1607	acyl-coa hydrolase
GFX43_014500	COG1834	amidinotransferase
GFX43_014505	COG2706	6-phosphogluconolactonase activity
GFX43_014510	COG4608	Belongs to the ABC transporter superfamily
GFX43_014515	COG0791	NLP P60 protein
GFX43_014520	COG4948	Mandelate Racemase Muconate Lactonizing
GFX43_014525	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFX43_014530	COG4166	transmembrane transport
GFX43_014535	COG0444	Belongs to the ABC transporter superfamily
GFX43_014540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFX43_014545	COG0601	transmembrane transport
GFX43_014550	COG2362	D-Aminopeptidase
GFX43_014555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFX43_014560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFX43_014565	COG0463	Glycosyl transferase, family 2
GFX43_014570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GFX43_014580	COG0346	lactoylglutathione lyase activity
GFX43_014585	COG0531	amino acid
GFX43_014590	COG1392	Phosphate transport regulator
GFX43_014595	COG0306	phosphate transporter
GFX43_014615	COG3409	Peptidoglycan-binding domain 1 protein
GFX43_014615	COG5632	N-Acetylmuramoyl-L-alanine amidase
GFX43_014655	COG3778	Protein conserved in bacteria
GFX43_014660	COG3299	homolog of phage Mu protein gp47
GFX43_014665	COG3628	GPW Gp25 family protein
GFX43_014675	COG4193	domain, Protein
GFX43_014680	COG1652	LysM domain
GFX43_014685	COG5412	phage tail tape measure protein
GFX43_014685	COG3953	SLT domain
GFX43_014735	COG4653	Phage capsid family
GFX43_014740	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GFX43_014745	COG5518	Phage portal protein
GFX43_014750	COG1783	phage Terminase large subunit
GFX43_014755	COG5484	DNA packaging
GFX43_014755	COG3728	DNA packaging
GFX43_014760	COG1595	DNA-templated transcription, initiation
GFX43_014780	COG1484	DNA-dependent DNA replication
GFX43_014785	COG1522	sequence-specific DNA binding
GFX43_014795	COG1396	sequence-specific DNA binding
GFX43_014800	COG2856	Zn peptidase
GFX43_014805	COG3546	catalase activity
GFX43_014810	COG4195	phage-related replication protein
GFX43_014820	COG3409	Peptidoglycan-binding domain 1 protein
GFX43_014820	COG1388	LysM domain
GFX43_014820	COG5632	N-Acetylmuramoyl-L-alanine amidase
GFX43_014825	COG2350	Protein conserved in bacteria
GFX43_014835	COG0457	Tetratricopeptide repeat
GFX43_014840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFX43_014845	COG2318	DinB family
GFX43_014850	COG0730	response to heat
GFX43_014855	COG2721	sulfolactate sulfo-lyase activity
GFX43_014860	COG0246	Mannitol dehydrogenase
GFX43_014865	COG1609	Transcriptional regulator
GFX43_014870	COG2271	Major facilitator Superfamily
GFX43_014875	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_014880	COG1312	Catalyzes the dehydration of D-mannonate
GFX43_014885	COG1063	alcohol dehydrogenase
GFX43_014890	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GFX43_014895	COG2211	Major facilitator Superfamily
GFX43_014900	COG1904	glucuronate isomerase
GFX43_014905	COG1252	NADH dehydrogenase
GFX43_014915	COG4297	protein containing double-stranded beta helix domain
GFX43_014920	COG0697	spore germination
GFX43_014925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFX43_014930	COG0390	transport system, permease component
GFX43_014935	COG1587	Uroporphyrinogen-III synthase
GFX43_014945	COG1819	glycosyl
GFX43_014950	COG2124	cytochrome p450
GFX43_014970	COG2427	Protein of unknown function (DUF1641)
GFX43_014975	COG3383	formate dehydrogenase (NAD+) activity
GFX43_014985	COG2205	protein histidine kinase activity
GFX43_014990	COG5504	Zn-dependent protease
GFX43_015005	COG0726	polysaccharide deacetylase
GFX43_015015	COG0109	protoheme IX farnesyltransferase activity
GFX43_015035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFX43_015045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFX43_015055	COG1482	cell wall glycoprotein biosynthetic process
GFX43_015060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFX43_015060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFX43_015060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFX43_015065	COG3711	transcriptional antiterminator
GFX43_015065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFX43_015075	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GFX43_015130	COG5505	Protein of unknown function (DUF819)
GFX43_015135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFX43_015140	COG0626	cystathionine gamma-synthase activity
GFX43_015145	COG0626	cystathionine gamma-synthase activity
GFX43_015150	COG2382	esterase
GFX43_015155	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GFX43_015160	COG2153	protein acetylation
GFX43_015170	COG0210	DNA helicase
GFX43_015225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GFX43_015230	COG0351	phosphomethylpyrimidine kinase
GFX43_015235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFX43_015240	COG2022	thiamine diphosphate biosynthetic process
GFX43_015245	COG2104	thiamine diphosphate biosynthetic process
GFX43_015250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFX43_015255	COG0352	thiamine-phosphate diphosphorylase activity
GFX43_015260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFX43_015265	COG0569	domain protein
GFX43_015265	COG0475	glutathione-regulated potassium exporter activity
GFX43_015270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GFX43_015275	COG0564	pseudouridine synthase activity
GFX43_015280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFX43_015285	COG2357	RelA SpoT domain protein
GFX43_015295	COG4116	CYTH
GFX43_015300	COG0741	lytic transglycosylase activity
GFX43_015305	COG2346	COG2346, Truncated hemoglobins
GFX43_015320	COG1164	Oligoendopeptidase f
GFX43_015325	COG4469	Competence protein
GFX43_015335	COG4862	establishment of competence for transformation
GFX43_015345	COG0861	Integral membrane protein TerC family
GFX43_015350	COG1393	Belongs to the ArsC family
GFX43_015355	COG0456	acetyltransferase
GFX43_015360	COG2814	Major facilitator Superfamily
GFX43_015365	COG4608	Belongs to the ABC transporter superfamily
GFX43_015370	COG0444	Belongs to the ABC transporter superfamily
GFX43_015375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFX43_015380	COG0601	transmembrane transport
GFX43_015385	COG4166	transmembrane transport
GFX43_015390	COG0180	Tryptophanyl-tRNA synthetase
GFX43_015400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFX43_015405	COG0601	transmembrane transport
GFX43_015415	COG4608	Belongs to the ABC transporter superfamily
GFX43_015420	COG0444	Belongs to the ABC transporter superfamily
GFX43_015425	COG5504	Zn-dependent protease
GFX43_015430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFX43_015435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFX43_015450	COG1744	ABC transporter substrate-binding protein PnrA-like
GFX43_015460	COG2267	carboxylic ester hydrolase activity
GFX43_015475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFX43_015480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GFX43_015485	COG0505	Belongs to the CarA family
GFX43_015490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFX43_015505	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GFX43_015510	COG2271	Major facilitator Superfamily
GFX43_015515	COG0277	FAD linked oxidase domain protein
GFX43_015525	COG2151	metal-sulfur cluster biosynthetic enzyme
GFX43_015530	COG1073	alpha beta
GFX43_015535	COG0561	phosphatase activity
GFX43_015550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFX43_015555	COG1307	EDD domain protein, DegV family
GFX43_015560	COG3227	Zinc metalloprotease (Elastase)
GFX43_015575	COG1695	Transcriptional regulator
GFX43_015595	COG2996	Protein conserved in bacteria
GFX43_015605	COG0646	methionine synthase
GFX43_015605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GFX43_015610	COG2153	protein acetylation
GFX43_015615	COG0454	-acetyltransferase
GFX43_015620	COG2814	Major facilitator Superfamily
GFX43_015625	COG4948	Mandelate Racemase Muconate Lactonizing
GFX43_015630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFX43_015635	COG1809	phosphosulfolactate synthase activity
GFX43_015640	COG2045	Belongs to the ComB family
GFX43_015645	COG0175	sulfate reduction
GFX43_015650	COG2046	Belongs to the sulfate adenylyltransferase family
GFX43_015655	COG0529	Catalyzes the synthesis of activated sulfate
GFX43_015660	COG2267	carboxylic ester hydrolase activity
GFX43_015665	COG1357	PFAM Pentapeptide repeats (8 copies)
GFX43_015670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFX43_015675	COG1279	arginine transmembrane transporter activity
GFX43_015680	COG2318	DinB family
GFX43_015685	COG0673	inositol 2-dehydrogenase activity
GFX43_015690	COG1609	Transcriptional regulator
GFX43_015695	COG2207	Transcriptional regulator
GFX43_015695	COG1917	Cupin 2, conserved barrel domain protein
GFX43_015700	COG0534	Mate efflux family protein
GFX43_015705	COG1562	ergosterol biosynthetic process
GFX43_015710	COG0367	asparagine synthase
GFX43_015720	COG1404	Belongs to the peptidase S8 family
GFX43_015730	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFX43_015735	COG5337	Spore coat protein CotH
GFX43_015775	COG1403	HNH endonuclease
GFX43_015780	COG0419	ATPase involved in DNA repair
GFX43_015785	COG0420	3'-5' exonuclease activity
GFX43_015790	COG1074	ATP-dependent DNA helicase activity
GFX43_015795	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GFX43_015800	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GFX43_015810	COG4533	DNA binding
GFX43_015815	COG0477	Major facilitator Superfamily
GFX43_015815	COG2814	Major facilitator Superfamily
GFX43_015820	COG3180	Ammonia monooxygenase
GFX43_015825	COG1609	Transcriptional regulator
GFX43_015830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFX43_015835	COG0561	phosphatase activity
GFX43_015840	COG0673	inositol 2-dehydrogenase activity
GFX43_015845	COG0738	Major facilitator superfamily
GFX43_015850	COG1846	Transcriptional regulator
GFX43_015855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFX43_015860	COG0681	Belongs to the peptidase S26 family
GFX43_015865	COG0398	Pfam SNARE associated Golgi protein
GFX43_015880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFX43_015890	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_015895	COG4903	ComK protein
GFX43_015905	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_015910	COG0723	plastoquinol--plastocyanin reductase activity
GFX43_015910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFX43_015915	COG0840	transmembrane signaling receptor activity
GFX43_015920	COG1268	BioY protein
GFX43_015925	COG0318	PFAM AMP-dependent synthetase and ligase
GFX43_015930	COG0183	Belongs to the thiolase family
GFX43_015935	COG0406	alpha-ribazole phosphatase activity
GFX43_015940	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GFX43_015945	COG0604	alcohol dehydrogenase
GFX43_015955	COG1404	Belongs to the peptidase S8 family
GFX43_015960	COG0501	Belongs to the peptidase M48B family
GFX43_015970	COG0318	PFAM AMP-dependent synthetase and ligase
GFX43_015975	COG0702	epimerase
GFX43_015980	COG0095	Lipoate-protein ligase
GFX43_015985	COG1234	tRNA 3'-trailer cleavage
GFX43_015995	COG1301	dicarboxylic acid transport
GFX43_016000	COG4405	Protein conserved in bacteria
GFX43_016005	COG1363	Peptidase, m42
GFX43_016015	COG4377	Putative membrane peptidase family (DUF2324)
GFX43_016020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFX43_016025	COG1511	domain protein
GFX43_016030	COG1309	transcriptional regulator
GFX43_016045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GFX43_016050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFX43_016055	COG2329	Antibiotic biosynthesis monooxygenase
GFX43_016065	COG3069	C4-dicarboxylate transmembrane transporter activity
GFX43_016070	COG1473	amidohydrolase
GFX43_016080	COG4473	ABC transporter
GFX43_016085	COG1131	(ABC) transporter
GFX43_016090	COG0537	adenosine 5'-monophosphoramidase activity
GFX43_016095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GFX43_016110	COG4980	gas vesicle protein
GFX43_016115	COG1846	Transcriptional regulator
GFX43_016145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFX43_016155	COG3481	metal-dependent phosphohydrolase, HD sub domain
GFX43_016160	COG4717	serine-type aminopeptidase activity
GFX43_016165	COG0420	3'-5' exonuclease activity
GFX43_016170	COG1668	transmembrane transport
GFX43_016175	COG4152	abc transporter atp-binding protein
GFX43_016185	COG1024	Enoyl-CoA hydratase
GFX43_016195	COG0490	domain, Protein
GFX43_016200	COG0475	glutathione-regulated potassium exporter activity
GFX43_016205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFX43_016210	COG0561	phosphatase activity
GFX43_016215	COG4335	DNA alkylation repair
GFX43_016220	COG3679	Belongs to the UPF0342 family
GFX43_016225	COG4399	Belongs to the UPF0754 family
GFX43_016230	COG0189	ligase activity
GFX43_016235	COG0189	ligase activity
GFX43_016255	COG0702	epimerase
GFX43_016260	COG1132	(ABC) transporter
GFX43_016265	COG1132	(ABC) transporter
GFX43_016275	COG0589	response to stress
GFX43_016280	COG1757	Na H antiporter
GFX43_016285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFX43_016290	COG0726	polysaccharide deacetylase
GFX43_016295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFX43_016300	COG0668	transmembrane transport
GFX43_016310	COG0584	glycerophosphoryl diester phosphodiesterase
GFX43_016315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFX43_016320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFX43_016325	COG1253	flavin adenine dinucleotide binding
GFX43_016330	COG0436	Aminotransferase
GFX43_016335	COG0789	Transcriptional regulator
GFX43_016340	COG1253	flavin adenine dinucleotide binding
GFX43_016345	COG0204	Acyl-transferase
GFX43_016350	COG0667	Aldo Keto reductase
GFX43_016355	COG1595	DNA-templated transcription, initiation
GFX43_016370	COG0456	acetyltransferase
GFX43_016380	COG0733	neurotransmitter:sodium symporter activity
GFX43_016385	COG0531	amino acid
GFX43_016390	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_016395	COG0372	Belongs to the citrate synthase family
GFX43_016400	COG0583	DNA-binding transcription factor activity
GFX43_016405	COG1388	LysM domain
GFX43_016405	COG0791	NLP P60 protein
GFX43_016410	COG1785	Belongs to the alkaline phosphatase family
GFX43_016415	COG2719	SpoVR family
GFX43_016420	COG0668	transmembrane transport
GFX43_016430	COG1959	2 iron, 2 sulfur cluster binding
GFX43_016435	COG0791	NLP P60 protein
GFX43_016435	COG1388	LysM domain
GFX43_016450	COG0431	NADPH-dependent FMN reductase
GFX43_016455	COG2197	response regulator
GFX43_016460	COG4585	Histidine kinase
GFX43_016460	COG2203	Gaf domain
GFX43_016465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFX43_016470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GFX43_016475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFX43_016480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFX43_016485	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GFX43_016490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFX43_016495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFX43_016495	COG3153	acetyltransferase
GFX43_016500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFX43_016505	COG0517	IMP dehydrogenase activity
GFX43_016515	COG0564	pseudouridine synthase activity
GFX43_016520	COG3764	Sortase (surface protein transpeptidase)
GFX43_016525	COG0737	Belongs to the 5'-nucleotidase family
GFX43_016525	COG4085	toxin activity
GFX43_016525	COG1525	nuclease
GFX43_016530	COG5577	PFAM Coat F domain
GFX43_016550	COG1823	symporter activity
GFX43_016555	COG3706	GGDEF domain
GFX43_016560	COG1464	Belongs to the NlpA lipoprotein family
GFX43_016565	COG1278	Cold shock
GFX43_016570	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GFX43_016575	COG1131	(ABC) transporter
GFX43_016580	COG1131	(ABC) transporter
GFX43_016585	COG1725	Transcriptional regulator
GFX43_016605	COG0655	NAD(P)H dehydrogenase (quinone) activity
GFX43_016610	COG2814	Major facilitator Superfamily
GFX43_016615	COG1566	PFAM secretion protein HlyD family protein
GFX43_016620	COG1846	Transcriptional regulator
GFX43_016625	COG2718	Belongs to the UPF0229 family
GFX43_016630	COG2766	serine protein kinase
GFX43_016635	COG1664	Polymer-forming cytoskeletal
GFX43_016640	COG1664	Polymer-forming cytoskeletal
GFX43_016645	COG0789	Transcriptional regulator
GFX43_016650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GFX43_016660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GFX43_016665	COG3382	B3 4 domain protein
GFX43_016675	COG1476	TRANSCRIPTIONal
GFX43_016685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFX43_016695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFX43_016700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFX43_016705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFX43_016710	COG1116	anion transmembrane transporter activity
GFX43_016715	COG0753	catalase activity
GFX43_016730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GFX43_016735	COG3340	Belongs to the peptidase S51 family
GFX43_016740	COG5577	PFAM Coat F domain
GFX43_016750	COG4326	sporulation control protein
GFX43_016860	COG0735	belongs to the Fur family
GFX43_016865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFX43_016870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFX43_016875	COG4129	membrane
GFX43_016880	COG1132	(ABC) transporter
GFX43_016885	COG3557	Belongs to the UPF0374 family
GFX43_016900	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_016910	COG1194	a g-specific adenine glycosylase
GFX43_016915	COG1988	membrane-bound metal-dependent
GFX43_016920	COG4485	Bacterial membrane protein, YfhO
GFX43_016925	COG0463	Glycosyl transferase, family 2
GFX43_016930	COG0596	Alpha beta hydrolase
GFX43_016935	COG5658	integral membrane protein
GFX43_016940	COG3103	Sh3 type 3 domain protein
GFX43_016955	COG2814	Major facilitator Superfamily
GFX43_016965	COG2137	regulation of response to DNA damage stimulus
GFX43_016970	COG1090	epimerase
GFX43_016985	COG0778	Nitroreductase
GFX43_016990	COG0384	phenazine biosynthesis protein PhzF
GFX43_016995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_017000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_017005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFX43_017010	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GFX43_017010	COG0392	lysyltransferase activity
GFX43_017015	COG1846	Transcriptional regulator
GFX43_017020	COG2814	Major facilitator Superfamily
GFX43_017025	COG2318	DinB family
GFX43_017030	COG2814	Major facilitator Superfamily
GFX43_017035	COG1309	transcriptional regulator
GFX43_017040	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GFX43_017045	COG1131	(ABC) transporter
GFX43_017065	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GFX43_017070	COG1695	Transcriptional regulator
GFX43_017080	COG0842	Transport permease protein
GFX43_017085	COG0842	Transport permease protein
GFX43_017085	COG1511	domain protein
GFX43_017090	COG1131	(ABC) transporter
GFX43_017095	COG2197	response regulator
GFX43_017100	COG4585	Histidine kinase
GFX43_017105	COG2514	catechol 2,3-dioxygenase activity
GFX43_017110	COG2259	Doxx family
GFX43_017115	COG1132	(ABC) transporter
GFX43_017120	COG1132	(ABC) transporter
GFX43_017125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_017125	COG1263	PTS System
GFX43_017130	COG1737	Transcriptional regulator
GFX43_017135	COG1486	melibiose metabolic process
GFX43_017140	COG4842	Belongs to the WXG100 family
GFX43_017160	COG1742	UPF0060 membrane protein
GFX43_017170	COG3284	Transcriptional regulator
GFX43_017175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFX43_017180	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFX43_017185	COG0022	dehydrogenase e1 component
GFX43_017190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFX43_017200	COG4637	Psort location Cytoplasmic, score
GFX43_017205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFX43_017215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFX43_017220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GFX43_017225	COG0598	Magnesium transport protein CorA
GFX43_017230	COG2084	Dehydrogenase
GFX43_017235	COG0726	polysaccharide deacetylase
GFX43_017245	COG0535	radical SAM domain protein
GFX43_017250	COG0668	transmembrane transport
GFX43_017260	COG0387	Pfam Sodium calcium exchanger
GFX43_017265	COG0477	Major facilitator Superfamily
GFX43_017270	COG1295	ribonuclease BN
GFX43_017275	COG4980	gas vesicle protein
GFX43_017280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFX43_017285	COG4840	Belongs to the UPF0435 family
GFX43_017290	COG2814	Major facilitator Superfamily
GFX43_017295	COG0693	protein deglycase activity
GFX43_017300	COG0737	Belongs to the 5'-nucleotidase family
GFX43_017305	COG0778	Nitroreductase
GFX43_017310	COG2188	Transcriptional regulator
GFX43_017315	COG0366	Alpha amylase catalytic
GFX43_017320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_017320	COG1263	PTS System
GFX43_017325	COG0697	spore germination
GFX43_017340	COG0531	amino acid
GFX43_017345	COG1115	amino acid carrier protein
GFX43_017360	COG1368	sulfuric ester hydrolase activity
GFX43_017365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_017365	COG1263	PTS System
GFX43_017370	COG0024	Methionine aminopeptidase
GFX43_017390	COG2258	MOSC domain
GFX43_017395	COG1254	Belongs to the acylphosphatase family
GFX43_017400	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GFX43_017405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFX43_017410	COG2851	Citrate transporter
GFX43_017415	COG3181	Tripartite tricarboxylate transporter family receptor
GFX43_017420	COG4565	transcriptional regulatory protein
GFX43_017425	COG3290	protein histidine kinase activity
GFX43_017430	COG0471	metal ion transport
GFX43_017435	COG3866	Pectate lyase
GFX43_017450	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GFX43_017455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_017460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_017465	COG1120	ATPase activity
GFX43_017470	COG2130	NADP-dependent
GFX43_017475	COG0456	acetyltransferase
GFX43_017480	COG0513	Belongs to the DEAD box helicase family
GFX43_017485	COG0488	(ABC) transporter
GFX43_017500	COG2814	Major facilitator Superfamily
GFX43_017505	COG0789	Transcriptional regulator
GFX43_017515	COG0488	(ABC) transporter
GFX43_017520	COG0840	transmembrane signaling receptor activity
GFX43_017525	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_017530	COG0531	amino acid
GFX43_017535	COG1011	Hydrolase
GFX43_017540	COG2223	nitrite transmembrane transporter activity
GFX43_017545	COG1442	glycosyl transferase family 8
GFX43_017550	COG1216	Glycosyl transferase, family 2
GFX43_017555	COG1442	glycosyl transferase family 8
GFX43_017560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFX43_017565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFX43_017570	COG1368	sulfuric ester hydrolase activity
GFX43_017575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GFX43_017575	COG2124	cytochrome p450
GFX43_017585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFX43_017590	COG0670	Belongs to the BI1 family
GFX43_017595	COG5583	Uncharacterized small protein (DUF2292)
GFX43_017610	COG0346	lactoylglutathione lyase activity
GFX43_017615	COG2329	Antibiotic biosynthesis monooxygenase
GFX43_017620	COG2323	membrane
GFX43_017625	COG1486	melibiose metabolic process
GFX43_017630	COG0395	ABC-type sugar transport system, permease component
GFX43_017635	COG4209	transmembrane transport
GFX43_017640	COG1653	transport
GFX43_017650	COG1874	Beta-galactosidase
GFX43_017655	COG2755	lipolytic protein G-D-S-L family
GFX43_017660	COG3401	FG-GAP repeat protein
GFX43_017665	COG3401	FG-GAP repeat protein
GFX43_017670	COG5578	integral membrane protein
GFX43_017680	COG2755	lipolytic protein G-D-S-L family
GFX43_017685	COG2207	Transcriptional regulator
GFX43_017690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFX43_017695	COG0395	ABC-type sugar transport system, permease component
GFX43_017700	COG1175	transmembrane transport
GFX43_017705	COG1653	transport
GFX43_017710	COG4753	response regulator
GFX43_017710	COG2207	Transcriptional regulator
GFX43_017715	COG2972	Histidine kinase
GFX43_017720	COG5578	integral membrane protein
GFX43_017730	COG0454	-acetyltransferase
GFX43_017735	COG3546	catalase activity
GFX43_017750	COG0702	epimerase
GFX43_017755	COG3631	Ketosteroid isomerase-related protein
GFX43_017760	COG1309	transcriptional regulator
GFX43_017770	COG0217	transcriptional regulatory protein
GFX43_017780	COG0457	Tetratricopeptide repeat
GFX43_017790	COG3586	endonuclease activity
GFX43_017800	COG5444	nuclease activity
GFX43_017850	COG5293	efflux transmembrane transporter activity
GFX43_017860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GFX43_017865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFX43_017870	COG1597	lipid kinase activity
GFX43_017875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFX43_017880	COG1309	transcriptional regulator
GFX43_017885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFX43_017890	COG0154	amidase activity
GFX43_017895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFX43_017900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFX43_017905	COG1285	pathogenesis
GFX43_017910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GFX43_017915	COG4851	CamS sex pheromone cAM373 precursor
GFX43_017920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFX43_017925	COG0210	DNA helicase
GFX43_017930	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GFX43_017935	COG0069	glutamate synthase activity
GFX43_017940	COG4496	protein, YerC YecD
GFX43_017945	COG1470	cell adhesion involved in biofilm formation
GFX43_017950	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GFX43_017960	COG0531	amino acid
GFX43_017965	COG1522	sequence-specific DNA binding
GFX43_017970	COG0151	Belongs to the GarS family
GFX43_017975	COG0138	bifunctional purine biosynthesis protein purh
GFX43_017980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GFX43_017985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFX43_017990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFX43_017995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFX43_018000	COG0047	phosphoribosylformylglycinamidine synthase activity
GFX43_018005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFX43_018010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFX43_018015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFX43_018020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFX43_018025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFX43_018035	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GFX43_018045	COG3064	Membrane
GFX43_018050	COG2252	PERMEase
GFX43_018065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFX43_018065	COG0519	Catalyzes the synthesis of GMP from XMP
GFX43_018075	COG1305	Transglutaminase-like
GFX43_018080	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GFX43_018085	COG0714	Associated with various cellular activities
GFX43_018090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GFX43_018100	COG1113	amino acid transport
GFX43_018105	COG2132	Multicopper oxidase
GFX43_018115	COG2267	carboxylic ester hydrolase activity
GFX43_018130	COG0823	Involved in the tonB-independent uptake of proteins
GFX43_018135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GFX43_018140	COG1063	alcohol dehydrogenase
GFX43_018145	COG2814	Major facilitator Superfamily
GFX43_018155	COG4260	virion core protein, lumpy skin disease virus
GFX43_018160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GFX43_018165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFX43_018170	COG1842	Phage shock protein A
GFX43_018175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFX43_018180	COG2211	Major facilitator Superfamily
GFX43_018185	COG1063	alcohol dehydrogenase
GFX43_018190	COG0457	Tetratricopeptide repeat
GFX43_018195	COG1073	alpha beta
GFX43_018205	COG0459	protein refolding
GFX43_018210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFX43_018215	COG1266	CAAX protease self-immunity
GFX43_018225	COG0805	protein transport
GFX43_018230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFX43_018235	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GFX43_018240	COG0315	cyclic pyranopterin monophosphate synthase activity
GFX43_018245	COG0488	(ABC) transporter
GFX43_018250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFX43_018255	COG0456	acetyltransferase
GFX43_018260	COG1214	PFAM Peptidase M22, glycoprotease
GFX43_018265	COG0802	atpase or kinase
GFX43_018270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GFX43_018315	COG4124	Belongs to the glycosyl hydrolase 26 family
GFX43_018320	COG1482	cell wall glycoprotein biosynthetic process
GFX43_018325	COG1940	carbohydrate kinase activity
GFX43_018330	COG2188	Transcriptional regulator
GFX43_018335	COG2723	6-phospho-beta-galactosidase activity
GFX43_018340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFX43_018345	COG1447	Phosphotransferase system cellobiose-specific component IIA
GFX43_018350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFX43_018355	COG2814	Major facilitator Superfamily
GFX43_018360	COG1388	LysM domain
GFX43_018365	COG1078	dGTPase activity
GFX43_018370	COG0454	-acetyltransferase
GFX43_018380	COG5646	InterPro IPR014922
GFX43_018385	COG1785	Belongs to the alkaline phosphatase family
GFX43_018395	COG1819	glycosyl
GFX43_018400	COG3858	chitin binding
GFX43_018400	COG1388	LysM domain
GFX43_018405	COG1802	Transcriptional regulator
GFX43_018410	COG0730	response to heat
GFX43_018415	COG2814	Major facilitator Superfamily
GFX43_018420	COG1846	Transcriptional regulator
GFX43_018425	COG0778	Nitroreductase
GFX43_018430	COG2409	Drug exporters of the RND superfamily
GFX43_018430	COG1033	growth of symbiont in host cell
GFX43_018435	COG1846	Transcriptional regulator
GFX43_018440	COG2318	DinB family
GFX43_018445	COG1113	amino acid transport
GFX43_018460	COG2814	Major facilitator Superfamily
GFX43_018470	COG0456	acetyltransferase
GFX43_018480	COG1309	transcriptional regulator
GFX43_018495	COG0071	Belongs to the small heat shock protein (HSP20) family
GFX43_018505	COG2323	membrane
GFX43_018525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFX43_018530	COG2259	Doxx family
GFX43_018535	COG0346	lactoylglutathione lyase activity
GFX43_018540	COG0778	Nitroreductase
GFX43_018545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GFX43_018550	COG0789	Transcriptional regulator
GFX43_018550	COG4978	Transcriptional regulator
GFX43_018555	COG1811	Na channel or pump
GFX43_018560	COG0596	Alpha beta hydrolase
GFX43_018565	COG2409	Drug exporters of the RND superfamily
GFX43_018570	COG2197	response regulator
GFX43_018575	COG4585	Histidine kinase
GFX43_018590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFX43_018595	COG0640	Transcriptional regulator
GFX43_018600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFX43_018605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFX43_018610	COG0697	spore germination
GFX43_018615	COG0745	RESPONSE REGULATOR receiver
GFX43_018620	COG5002	protein histidine kinase activity
GFX43_018630	COG0726	polysaccharide deacetylase
GFX43_018640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFX43_018650	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GFX43_018655	COG0640	Transcriptional regulator
GFX43_018665	COG1309	transcriptional regulator
GFX43_018670	COG2814	Major facilitator Superfamily
GFX43_018675	COG2249	NAD(P)H dehydrogenase (quinone) activity
GFX43_018680	COG1733	regulation of RNA biosynthetic process
GFX43_018685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFX43_018690	COG1733	regulation of RNA biosynthetic process
GFX43_018695	COG3545	Serine hydrolase
GFX43_018700	COG2030	dehydratase
GFX43_018705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFX43_018710	COG0697	spore germination
GFX43_018725	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GFX43_018735	COG0477	Major facilitator Superfamily
GFX43_018740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFX43_018745	COG2207	Transcriptional regulator
GFX43_018745	COG3708	Transcriptional regulator
GFX43_018750	COG0697	spore germination
GFX43_018755	COG1917	Cupin 2, conserved barrel domain protein
GFX43_018755	COG2207	Transcriptional regulator
GFX43_018760	COG1329	Transcriptional regulator
GFX43_018765	COG1278	Cold shock
GFX43_018775	COG3239	Fatty acid desaturase
GFX43_018785	COG1476	TRANSCRIPTIONal
GFX43_018805	COG1132	(ABC) transporter
GFX43_018810	COG0515	serine threonine protein kinase
GFX43_018815	COG0515	serine threonine protein kinase
GFX43_018865	COG3091	SprT-like family
GFX43_018875	COG2183	response to ionizing radiation
GFX43_018880	COG1846	Transcriptional regulator
GFX43_018885	COG1673	EVE domain
GFX43_018895	COG2208	phosphoserine phosphatase activity
GFX43_018900	COG1191	sigma factor activity
GFX43_018905	COG2172	sigma factor antagonist activity
GFX43_018910	COG1366	Belongs to the anti-sigma-factor antagonist family
GFX43_018915	COG2208	phosphoserine phosphatase activity
GFX43_018920	COG2172	sigma factor antagonist activity
GFX43_018925	COG1366	Belongs to the anti-sigma-factor antagonist family
GFX43_018930	COG1366	Belongs to the anti-sigma-factor antagonist family
GFX43_018935	COG2337	Toxic component of a toxin-antitoxin (TA) module
GFX43_018940	COG0864	Transcriptional regulator
GFX43_018945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFX43_018950	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GFX43_018955	COG0736	holo-[acyl-carrier-protein] synthase activity
GFX43_018960	COG0705	Rhomboid family
GFX43_018965	COG3428	Bacterial PH domain
GFX43_018970	COG3402	PFAM membrane-flanked domain
GFX43_018975	COG0513	Belongs to the DEAD box helicase family
GFX43_018980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFX43_018985	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFX43_018990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFX43_018995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GFX43_019010	COG1960	acyl-CoA dehydrogenase activity
GFX43_019020	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GFX43_019025	COG1131	(ABC) transporter
GFX43_019030	COG0628	permease
GFX43_019035	COG1301	dicarboxylic acid transport
GFX43_019040	COG4565	transcriptional regulatory protein
GFX43_019045	COG3290	protein histidine kinase activity
GFX43_019050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GFX43_019055	COG3546	catalase activity
GFX43_019060	COG2329	Antibiotic biosynthesis monooxygenase
GFX43_019065	COG0662	Cupin 2, conserved barrel domain protein
GFX43_019070	COG3729	General stress protein
GFX43_019075	COG2217	Heavy metal translocating P-type atpase
GFX43_019080	COG4876	unkown
GFX43_019085	COG2261	transglycosylase associated protein
GFX43_019090	COG1914	H( )-stimulated, divalent metal cation uptake system
GFX43_019105	COG0028	Belongs to the TPP enzyme family
GFX43_019110	COG0494	nUDIX hydrolase
GFX43_019115	COG0531	amino acid
GFX43_019125	COG1215	transferase activity, transferring glycosyl groups
GFX43_019130	COG5298	Protein conserved in bacteria
GFX43_019135	COG3706	GGDEF domain
GFX43_019140	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GFX43_019145	COG0551	DNA topoisomerase type I activity
GFX43_019145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFX43_019150	COG1522	sequence-specific DNA binding
GFX43_019155	COG2814	Major facilitator Superfamily
GFX43_019165	COG3871	stress protein (general stress protein 26)
GFX43_019170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFX43_019175	COG1917	Cupin 2, conserved barrel domain protein
GFX43_019180	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_019185	COG2226	methyltransferase
GFX43_019190	COG0318	PFAM AMP-dependent synthetase and ligase
GFX43_019195	COG3711	transcriptional antiterminator
GFX43_019200	COG4989	oxidoreductase activity
GFX43_019205	COG0768	penicillin binding
GFX43_019210	COG2329	Antibiotic biosynthesis monooxygenase
GFX43_019220	COG2755	lipolytic protein G-D-S-L family
GFX43_019225	COG1414	Transcriptional regulator
GFX43_019230	COG1984	allophanate hydrolase subunit 2
GFX43_019235	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GFX43_019240	COG4336	lyase activity
GFX43_019245	COG1914	H( )-stimulated, divalent metal cation uptake system
GFX43_019250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GFX43_019255	COG0561	phosphatase activity
GFX43_019265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFX43_019270	COG0412	Dienelactone hydrolase
GFX43_019275	COG0681	Belongs to the peptidase S26 family
GFX43_019280	COG0473	3-isopropylmalate dehydrogenase activity
GFX43_019285	COG0246	Mannitol dehydrogenase
GFX43_019290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFX43_019295	COG2213	PTS system mannitol-specific
GFX43_019305	COG1349	DNA-binding transcription factor activity
GFX43_019310	COG2372	response to copper ion
GFX43_019310	COG1276	copper resistance
GFX43_019315	COG4549	nuclear export factor GLE1
GFX43_019320	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_019325	COG4975	Glucose uptake
GFX43_019330	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_019335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GFX43_019340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFX43_019345	COG0640	Transcriptional regulator
GFX43_019350	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GFX43_019355	COG0778	Nitroreductase
GFX43_019360	COG1309	transcriptional regulator
GFX43_019365	COG2814	Major facilitator Superfamily
GFX43_019370	COG4607	ABC-type enterochelin transport system periplasmic component
GFX43_019375	COG4604	ABC transporter, ATP-binding protein
GFX43_019380	COG4605	iron ion homeostasis
GFX43_019385	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_019390	COG0527	aspartate kinase activity
GFX43_019410	COG0457	Tetratricopeptide repeat
GFX43_019415	COG5002	protein histidine kinase activity
GFX43_019415	COG3850	Histidine kinase
GFX43_019420	COG0745	RESPONSE REGULATOR receiver
GFX43_019425	COG0577	efflux transmembrane transporter activity
GFX43_019430	COG1136	(ABC) transporter
GFX43_019435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GFX43_019445	COG0697	spore germination
GFX43_019455	COG5434	Belongs to the glycosyl hydrolase 28 family
GFX43_019460	COG3104	oligopeptide transport
GFX43_019465	COG0596	Alpha beta hydrolase
GFX43_019480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GFX43_019485	COG0163	prenyltransferase activity
GFX43_019490	COG0583	DNA-binding transcription factor activity
GFX43_019495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFX43_019500	COG0765	amino acid transport
GFX43_019505	COG1126	abc transporter atp-binding protein
GFX43_019510	COG2364	Membrane
GFX43_019520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFX43_019525	COG0697	spore germination
GFX43_019535	COG2814	Major facilitator Superfamily
GFX43_019540	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GFX43_019545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_019550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_019555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFX43_019560	COG1733	regulation of RNA biosynthetic process
GFX43_019565	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GFX43_019570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GFX43_019575	COG0840	transmembrane signaling receptor activity
GFX43_019575	COG3290	protein histidine kinase activity
GFX43_019580	COG3209	COG3209 Rhs family protein
GFX43_019590	COG2723	6-phospho-beta-galactosidase activity
GFX43_019610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFX43_019615	COG0765	amino acid transport
GFX43_019620	COG0523	cobalamin synthesis protein
GFX43_019630	COG1376	ErfK ybiS ycfS ynhG family protein
GFX43_019635	COG1469	GTP cyclohydrolase I activity
GFX43_019640	COG2223	nitrite transmembrane transporter activity
GFX43_019645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFX43_019650	COG0243	molybdopterin cofactor binding
GFX43_019655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFX43_019660	COG2146	nitrite reductase [NAD(P)H] activity
GFX43_019665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFX43_019665	COG1587	Uroporphyrinogen-III synthase
GFX43_019670	COG0492	ferredoxin-NADP+ reductase activity
GFX43_019675	COG2267	carboxylic ester hydrolase activity
GFX43_019680	COG0701	Predicted permease
GFX43_019685	COG3689	TIGRFAM TIGR03943 family protein
GFX43_019690	COG2508	Transcriptional regulator
GFX43_019695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFX43_019700	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_019705	COG0506	proline dehydrogenase activity
GFX43_019710	COG3541	Predicted nucleotidyltransferase
GFX43_019715	COG3458	cephalosporin-C deacetylase activity
GFX43_019720	COG0583	DNA-binding transcription factor activity
GFX43_019725	COG2226	methyltransferase
GFX43_019730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GFX43_019735	COG1660	Displays ATPase and GTPase activities
GFX43_019740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFX43_019745	COG3665	Urea carboxylase-associated protein
GFX43_019750	COG1113	amino acid transport
GFX43_019755	COG3403	YqcI/YcgG family
GFX43_019760	COG1280	lysine exporter protein (LysE YggA)
GFX43_019765	COG1846	Transcriptional regulator
GFX43_019770	COG2814	Major facilitator Superfamily
GFX43_019775	COG1620	l-lactate permease
GFX43_019780	COG0039	L-malate dehydrogenase activity
GFX43_019785	COG0366	Alpha amylase catalytic
GFX43_019795	COG1288	antiporter activity
GFX43_019800	COG1473	amidohydrolase
GFX43_019805	COG2113	Glycine betaine
GFX43_019810	COG4176	ABC-type proline glycine betaine transport system permease component
GFX43_019815	COG0517	IMP dehydrogenase activity
GFX43_019815	COG4175	Glycine betaine
GFX43_019820	COG0640	Transcriptional regulator
GFX43_019825	COG2814	Major facilitator Superfamily
GFX43_019830	COG0477	Major facilitator Superfamily
GFX43_019835	COG3853	Toxic anion resistance protein (TelA)
GFX43_019845	COG0861	Integral membrane protein TerC family
GFX43_019850	COG2310	stress, protein
GFX43_019855	COG2310	stress, protein
GFX43_019860	COG2310	stress, protein
GFX43_019865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFX43_019870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFX43_019875	COG1121	(ABC) transporter
GFX43_019880	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFX43_019885	COG0366	Alpha amylase catalytic
GFX43_019890	COG1028	Short-chain dehydrogenase reductase Sdr
GFX43_019895	COG0457	Tetratricopeptide repeat
GFX43_019900	COG1876	peptidase activity
GFX43_019905	COG1595	DNA-templated transcription, initiation
GFX43_019910	COG1595	DNA-templated transcription, initiation
GFX43_019925	COG0667	Aldo Keto reductase
GFX43_019930	COG1668	transmembrane transport
GFX43_019935	COG4555	ABC transporter
GFX43_019940	COG3279	Response regulator of the LytR AlgR family
GFX43_019945	COG3290	protein histidine kinase activity
GFX43_019950	COG1405	negative regulation of cell septum assembly
GFX43_019950	COG3012	SEC-C Motif Domain Protein
GFX43_019955	COG1714	RDD family
GFX43_019960	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GFX43_019965	COG0252	asparaginase activity
GFX43_019970	COG1309	transcriptional regulator
GFX43_019975	COG0477	Major facilitator Superfamily
GFX43_019980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFX43_019985	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GFX43_019990	COG0805	protein transport
GFX43_019995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFX43_020000	COG3540	Alkaline phosphatase
GFX43_020010	COG2304	oxidoreductase activity
GFX43_020015	COG3773	Cell wall hydrolase
GFX43_020035	COG1131	(ABC) transporter
GFX43_020040	COG2205	protein histidine kinase activity
GFX43_020045	COG0745	RESPONSE REGULATOR receiver
GFX43_020050	COG0697	spore germination
GFX43_020060	COG3173	Aminoglycoside phosphotransferase
GFX43_020065	COG2721	sulfolactate sulfo-lyase activity
GFX43_020070	COG2186	Transcriptional regulator
GFX43_020075	COG4948	Mandelate Racemase Muconate Lactonizing
GFX43_020080	COG2271	Major facilitator Superfamily
GFX43_020085	COG1012	belongs to the aldehyde dehydrogenase family
GFX43_020090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFX43_020095	COG0784	Response regulator, receiver
GFX43_020100	COG4191	Histidine kinase
GFX43_020105	COG2066	Belongs to the glutaminase family
GFX43_020110	COG1115	amino acid carrier protein
GFX43_020120	COG2040	homocysteine
GFX43_020125	COG0833	amino acid
GFX43_020130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFX43_020145	COG0363	glucosamine-6-phosphate deaminase activity
GFX43_020150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_020150	COG1263	PTS System
GFX43_020150	COG2190	(PTS) system
GFX43_020155	COG1301	dicarboxylic acid transport
GFX43_020165	COG2312	Erythromycin esterase
GFX43_020175	COG0688	phosphatidylethanolamine metabolic process
GFX43_020180	COG0586	Pfam SNARE associated Golgi protein
GFX43_020185	COG1183	phosphatidylcholine synthase activity
GFX43_020190	COG0596	Alpha beta hydrolase
GFX43_020200	COG3591	Belongs to the peptidase S1B family
GFX43_020205	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GFX43_020210	COG5444	nuclease activity
GFX43_020215	COG1397	ADP-ribosylglycohydrolase
GFX43_020220	COG2207	Transcriptional regulator
GFX43_020220	COG1917	Cupin 2, conserved barrel domain protein
GFX43_020225	COG0697	spore germination
GFX43_020235	COG2271	Major facilitator Superfamily
GFX43_020240	COG0456	acetyltransferase
GFX43_020240	COG1846	Transcriptional regulator
GFX43_020250	COG2271	Major facilitator Superfamily
GFX43_020255	COG0584	glycerophosphoryl diester phosphodiesterase
GFX43_020260	COG0531	amino acid
GFX43_020270	COG2124	cytochrome p450
GFX43_020275	COG2602	Beta-lactamase
GFX43_020290	COG1113	amino acid transport
GFX43_020305	COG0515	serine threonine protein kinase
GFX43_020315	COG0642	Histidine kinase
GFX43_020320	COG0745	RESPONSE REGULATOR receiver
GFX43_020325	COG0596	Alpha beta hydrolase
GFX43_020340	COG2814	Major facilitator Superfamily
GFX43_020345	COG0640	Transcriptional regulator
GFX43_020350	COG5609	conserved protein (DUF2294)
GFX43_020360	COG0288	reversible hydration of carbon dioxide
GFX43_020365	COG3002	Belongs to the UPF0753 family
GFX43_020370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFX43_020380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFX43_020385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFX43_020390	COG4856	YbbR-like protein
GFX43_020395	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GFX43_020400	COG5662	AntiSigma factor
GFX43_020405	COG1595	DNA-templated transcription, initiation
GFX43_020435	COG1683	Conserved Protein
GFX43_020440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFX43_020445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFX43_020450	COG1737	Transcriptional regulator
GFX43_020455	COG1263	PTS System
GFX43_020455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFX43_020460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFX43_020465	COG1472	Belongs to the glycosyl hydrolase 3 family
GFX43_020470	COG3876	Protein conserved in bacteria
GFX43_020475	COG2207	Transcriptional regulator
GFX43_020475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFX43_020480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFX43_020485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_020490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFX43_020495	COG2819	hydrolase of the alpha beta superfamily
GFX43_020500	COG0385	Bile acid
GFX43_020505	COG0659	secondary active sulfate transmembrane transporter activity