locus-tag class description AN935_00005 ENOG4105CEY Amp-dependent synthetase and ligase AN935_00015 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AN935_00025 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AN935_00030 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AN935_00035 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AN935_00045 ENOG4105ZMH deoxynucleoside kinase AN935_00055 ENOG4105VRS hydrolase family 18 AN935_00060 ENOG4105GTG Isochorismatase AN935_00065 ENOG4108Z6B deaminase AN935_00080 ENOG4105C6E dna polymerase iii AN935_00085 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AN935_00090 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AN935_00100 ENOG41067KS pro-sigma K processing AN935_00115 ENOG4105CDW Resistance protein AN935_00120 ENOG4105CXN decarboxylase AN935_00125 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AN935_00130 ENOG4105X0R protein from nitrogen regulatory protein P-II AN935_00135 ENOG4105XVJ Protein of unknown function (DUF327) AN935_00140 ENOG4105FA2 dna polymerase iii AN935_00145 ENOG4105MA4 psp1 domain protein AN935_00150 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) AN935_00155 ENOG41060K3 Methyltransferase AN935_00160 ENOG4105VC4 domain protein AN935_00165 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AN935_00170 ENOG4105KRN Transcriptional regulator, abrb family AN935_00175 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AN935_00180 ENOG4105F8V Hydrolase, tatD family AN935_00185 ENOG41069ER domain protein AN935_00195 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AN935_00200 ENOG4105XFA sporulation peptidase YabG AN935_00205 ENOG4105W42 Veg protein AN935_00210 ENOG4105XEW small acid-soluble spore protein AN935_00215 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AN935_00220 ENOG4105DFT pur operon repressor AN935_00225 ENOG4105KME endoribonuclease L-psp AN935_00230 ENOG4105K4W Could be involved in septation (By similarity) AN935_00240 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AN935_00245 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AN935_00250 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AN935_00255 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AN935_00265 ENOG4108JA2 transcriptioN-repair coupling factor AN935_00270 ENOG4108M14 stage v sporulation protein t AN935_00280 ENOG4108IY2 MazG family AN935_00285 ENOG41082I2 s4 domain protein AN935_00290 ENOG4105VYY sporulation protein yabp AN935_00305 ENOG41060GV RNA binding s1 domain protein AN935_00335 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AN935_00340 ENOG4108UGV hypoxanthine phosphoribosyltransferase AN935_00345 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AN935_00355 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AN935_00360 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase AN935_00365 ENOG4105C6T cysteine synthase AN935_00370 ENOG4105CRQ synthase (Component I) AN935_00375 ENOG4105DDQ anthranilate synthase AN935_00380 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AN935_00385 ENOG4105EEI dihydropteroate synthase AN935_00390 ENOG4105KRF dihydroneopterin aldolase AN935_00395 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AN935_00405 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AN935_00410 ENOG4105CRK lysyL-tRNA synthetase AN935_00425 ENOG4108Z0C Uvrb UvrC protein AN935_00430 ENOG41066A3 ATP guanido phosphotransferase AN935_00440 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AN935_00445 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) AN935_00450 ENOG4105CTP PilT protein domain protein AN935_00455 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AN935_00460 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AN935_00465 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AN935_00475 ENOG4105D7W serine acetyltransferase AN935_00480 ENOG4105C8N cysteinyl-tRNA synthetase AN935_00485 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) AN935_00490 ENOG4105C2N RNA methyltransferase TrmH family group 3 AN935_00495 ENOG4105M0M Tetracycline resistance protein AN935_00515 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AN935_00520 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AN935_00530 ENOG4108VZM 50s ribosomal protein L10 AN935_00535 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AN935_00540 ENOG4107Y49 methyltransferase AN935_00545 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AN935_00550 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AN935_00555 ENOG4105XPM ribosomal protein AN935_00560 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AN935_00565 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AN935_00570 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AN935_00575 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AN935_00580 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AN935_00585 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AN935_00590 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AN935_00595 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AN935_00600 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AN935_00605 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AN935_00610 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AN935_00615 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AN935_00620 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AN935_00625 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AN935_00630 ENOG41082SA 50s ribosomal protein l29 AN935_00635 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AN935_00640 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AN935_00650 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AN935_00660 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AN935_00665 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AN935_00670 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AN935_00675 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AN935_00680 ENOG4105VPB 50S ribosomal protein L30 AN935_00685 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AN935_00690 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AN935_00700 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AN935_00710 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AN935_00720 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AN935_00725 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AN935_00730 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AN935_00735 ENOG4108ZT0 50S ribosomal protein l17 AN935_00740 ENOG4108JJB ABC transporter AN935_00745 ENOG4108JJB ABC transporter AN935_00750 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AN935_00755 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AN935_00760 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AN935_00765 ENOG4108UJD 30S ribosomal protein S9 AN935_00770 ENOG4108I0C methyltransferase AN935_00785 ENOG4105D1F ATP-binding protein AN935_00800 ENOG4108NMV polysaccharide deacetylase AN935_00810 ENOG4108JPW Aminotransferase AN935_00820 ENOG4105CPQ Dehydrogenase AN935_00825 ENOG4105CHH sulfate transporter AN935_00835 ENOG4108SA1 esterase AN935_00855 ENOG410874W AraC family transcriptional regulator AN935_00860 ENOG4105EHZ conserved protein UCP016719 AN935_00865 ENOG4105D17 glycoside hydrolase, family 3 domain protein AN935_00885 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AN935_00895 ENOG4105EWC Purine nucleoside phosphorylase AN935_00910 ENOG4105CEY Amp-dependent synthetase and ligase AN935_00940 ENOG4105EMN RNA polymerase sigma factor AN935_00950 ENOG4105C8B TIGR00159 family AN935_00955 ENOG4107U5W ybbr family AN935_00960 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AN935_00970 ENOG4108TWJ NADH dehydrogenase subunit 5 AN935_00990 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AN935_00995 ENOG4105WAB arsR family transcriptional regulator AN935_01000 ENOG4108RWP Major Facilitator Superfamily protein AN935_01040 ENOG4105G0J serine threonine protein kinase AN935_01050 ENOG4106K80 AN935_01060 ENOG4106DDH Sporulation-specific SASP protein AN935_01070 ENOG4108HWY Beta-lactamase AN935_01075 ENOG4107E6A Cytochrome p-450 AN935_01085 ENOG4107QTZ amino acid AN935_01095 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AN935_01100 ENOG4105CXY transporter AN935_01110 ENOG410645S MarR family Transcriptional regulator AN935_01115 ENOG4105DCM major facilitator superfamily AN935_01130 ENOG410631K Membrane AN935_01135 ENOG4106AXJ AraC family transcriptional regulator AN935_01140 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AN935_01145 ENOG4108TCS Glutamyl endopeptidase AN935_01155 ENOG4108WC5 Alpha Beta Hydrolase Fold protein AN935_01160 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AN935_01165 ENOG4107ZTW SNARE associated Golgi AN935_01190 ENOG4105C72 UPF0176 protein AN935_01200 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane AN935_01205 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AN935_01210 ENOG4108X79 transcriptional regulator AN935_01220 ENOG4105CM2 brancheD-chain amino acid aminotransferase AN935_01225 ENOG4108IQI permease AN935_01230 ENOG4108J5H Homocysteine s-methyltransferase AN935_01245 ENOG4105CSV Glutaminase AN935_01260 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase AN935_01265 ENOG4105C26 Dehydrogenase AN935_01270 ENOG4105DJB Major Facilitator Superfamily AN935_01275 ENOG4105EQX glucarate dehydratase AN935_01280 ENOG41073TP transcriptional regulator AN935_01285 ENOG4105CTX dehydratase AN935_01300 ENOG4106UX7 integral membrane protein AN935_01305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AN935_01340 ENOG4105MUA Resistance protein AN935_01350 ENOG4105DGI Alkaline phosphatase AN935_01355 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AN935_01360 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AN935_01365 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AN935_01370 ENOG4107EPV Aminotransferase class V AN935_01375 ENOG4105C0R drug resistance transporter emrb qaca subfamily AN935_01380 ENOG4105J7D transcriptional regulator AN935_01385 ENOG4107RB3 L-asparaginase AN935_01390 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold AN935_01400 ENOG41060AI SEC-C motif AN935_01410 ENOG4107Y7X LytTR AN935_01415 ENOG4108IUW ABC transporter AN935_01420 ENOG4108SDH ABC, transporter AN935_01425 ENOG4107SET aldo keto reductase AN935_01455 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AN935_01465 ENOG4105DSE periplasmic solute binding protein AN935_01470 ENOG4105DIK (ABC) transporter AN935_01480 ENOG4105DEN Luciferase family AN935_01485 ENOG4108N0M stress protein AN935_01490 ENOG4106FN3 tellurium resistance protein AN935_01495 ENOG4106FN3 tellurium resistance protein AN935_01500 ENOG4107TS3 membrane protein, TerC AN935_01505 ENOG4108TTB tellurium resistance protein AN935_01515 ENOG41079KZ Major Facilitator Superfamily AN935_01520 ENOG4107XZQ multidrug resistance protein AN935_01525 ENOG4108A65 Transcriptional regulator AN935_01530 ENOG4108IJ7 Glycine betaine AN935_01535 ENOG4107SQ8 Glycine betaine AN935_01570 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AN935_01605 ENOG4105EIG urea carboxylase-associated protein 1 AN935_01610 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AN935_01615 ENOG4105I1F Resistance protein AN935_01620 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AN935_01625 ENOG41089UC methyltransferase, type 11 AN935_01630 ENOG4105C5Q Transcriptional regulator AN935_01635 ENOG4105I82 acetyl xylan esterase AN935_01640 ENOG410756H nucleotidyltransferase AN935_01650 ENOG4105C26 Dehydrogenase AN935_01655 ENOG4105CK7 Sodium proline symporter AN935_01660 ENOG4107YHD transcriptional regulator AN935_01670 ENOG4108PJD permease AN935_01685 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AN935_01690 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AN935_01695 ENOG4108IFG nitrite reductase, (NAD(P)H) AN935_01700 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AN935_01720 ENOG4105S7A ErfK ybiS ycfS ynhG family protein AN935_01730 ENOG4105CKI cobalamin synthesis protein AN935_01735 ENOG4105E5Q amino acid AbC transporter AN935_01740 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein AN935_01745 ENOG4105HHM rdd domain containing protein AN935_01755 ENOG4105K56 Transcriptional regulator AN935_01765 ENOG4108VEN abc transporter atp-binding protein AN935_01770 ENOG4105CS2 ec 3.2.1.21 AN935_01785 ENOG4105C8Q Methyl-accepting chemotaxis AN935_01790 ENOG41080HJ 6-phospho 3-hexuloisomerase AN935_01795 ENOG4108VA3 3-hexulose-6-phosphate synthase AN935_01800 ENOG4105KVH Transcriptional regulator AN935_01810 ENOG4105CEY Amp-dependent synthetase and ligase AN935_01835 ENOG4105SX7 Transporter AN935_01845 ENOG4105W8Z 4'-phosphopantetheinyl transferase AN935_01855 ENOG4105CDA abc transporter atp-binding protein AN935_01860 ENOG4105DRP amino acid AbC transporter AN935_01870 ENOG4106P55 Transcriptional regulator AN935_01875 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AN935_01880 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AN935_01885 ENOG41069ZX AN935_01890 ENOG41069ZX AN935_01900 ENOG4105DUX Transporter AN935_01915 ENOG4105E1K spore germination protein AN935_01935 ENOG4107WD8 ABC transporter, permease AN935_01940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AN935_01945 ENOG4105BZU Histidine kinase AN935_01965 ENOG4105CFH Aspartokinase AN935_01970 ENOG4105DHS permease protein AN935_01975 ENOG4105CM4 permease protein AN935_01980 ENOG4108IPW abc transporter atp-binding protein AN935_01995 ENOG4105R8C Transcriptional regulator AN935_02000 ENOG4108DBC nitroreductase AN935_02005 ENOG41067V3 Antibiotic biosynthesis monooxygenase AN935_02010 ENOG4105YVS arsR family transcriptional regulator AN935_02020 ENOG4108JPW Aminotransferase AN935_02025 ENOG4105C26 Dehydrogenase AN935_02035 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AN935_02040 ENOG4105KTB nuclear export factor GLE1 AN935_02045 ENOG4108T5E Copper resistance protein AN935_02050 ENOG4108ZYE Transcriptional regulator AN935_02075 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AN935_02100 ENOG4105E7W lamb ycsf family protein AN935_02105 ENOG4105C5A transporter AN935_02110 ENOG4105CFM UPF0317 protein AN935_02115 ENOG4105P4J Allophanate hydrolase, subunit 1 AN935_02125 ENOG4107258 Transcriptional regulator AN935_02130 ENOG4105XJB lipolytic protein G-D-S-L family AN935_02140 ENOG41061CK Antibiotic biosynthesis monooxygenase AN935_02145 ENOG4107RVG penicillin-binding protein AN935_02150 ENOG4107QM2 Aldo Keto reductase AN935_02155 ENOG4105ETD TRANSCRIPTIONal AN935_02165 ENOG4105HMZ Methyltransferase AN935_02170 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AN935_02185 ENOG410606W general stress protein AN935_02195 ENOG4105VCH membrane AN935_02205 ENOG4105C9U ATP-dependent DNA helicase RecQ AN935_02220 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AN935_02225 ENOG4107R8N Glycosyl transferase, family 2 AN935_02235 ENOG4105C0X amino acid AN935_02260 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AN935_02265 ENOG4107BMA Transglycosylase associated protein AN935_02270 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) AN935_02275 ENOG4105EU9 AN935_02280 ENOG4105QVS general stress protein AN935_02285 ENOG41082W1 Cupin 2, conserved barrel domain protein AN935_02300 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AN935_02305 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AN935_02310 ENOG4108MRH transcriptional regulatory protein AN935_02315 ENOG4107QJT sodium dicarboxylate symporter AN935_02320 ENOG4106F5Q Membrane AN935_02330 ENOG4105CJ1 ABC, transporter AN935_02345 ENOG4105FDT acyl-CoA dehydrogenase AN935_02365 ENOG4105SZ6 Thioredoxin AN935_02370 ENOG4105CPF Cell wall formation (By similarity) AN935_02375 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AN935_02385 ENOG4105C1J atp-dependent rna helicase AN935_02390 ENOG410905X membrane-flanked domain protein AN935_02395 ENOG4105CKV Membrane AN935_02405 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AN935_02410 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AN935_02415 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AN935_02425 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AN935_02430 ENOG4107MMM Anti-sigma-factor antagonist AN935_02435 ENOG4105FUA antagonist AN935_02440 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase AN935_02445 ENOG4107SGM protein serine threonine phosphatase AN935_02450 ENOG4105WN5 stage II sporulation protein AN935_02455 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AN935_02465 ENOG41064BQ Phosphatase AN935_02525 ENOG4105K56 Transcriptional regulator AN935_02530 ENOG4105EA8 2-Nitropropane dioxygenase AN935_02540 ENOG41090E6 transcriptional regulator MERR family AN935_02560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AN935_02565 ENOG4108594 Permease of the drug metabolite transporter AN935_02570 ENOG4105VZ8 Transcriptional regulator AN935_02580 ENOG4105K4H Nlp p60 protein AN935_02590 ENOG4105DJ2 Major Facilitator Superfamily AN935_02600 ENOG4105VEQ Cold shock protein AN935_02605 ENOG4108VJ1 Transcriptional regulator (CarD family AN935_02610 ENOG41086D8 Transcriptional regulator AN935_02620 ENOG4105CZ9 Domain of unknown function (DU1801) AN935_02625 ENOG4105F27 Major Facilitator AN935_02630 ENOG4105KRI phosphocarrier protein (HPr AN935_02635 ENOG4105ST3 Transcriptional regulator AN935_02640 ENOG4105Z7P Acetyltransferase (GNAT) family AN935_02645 ENOG4108KGH TRANSCRIPTIONal AN935_02650 ENOG4108ZJ4 polysaccharide deacetylase AN935_02660 ENOG4105US7 Histidine kinase AN935_02665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AN935_02670 ENOG4108JYZ YitT family AN935_02680 ENOG4105CTU Proline racemase AN935_02690 ENOG4107RSM transcriptional regulator AN935_02695 ENOG4105C9Q fumarate hydratase class II AN935_02700 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AN935_02710 ENOG4105T38 integral membrane protein AN935_02715 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AN935_02720 ENOG4108ZMQ domain protein AN935_02725 ENOG4105MJ9 esterase AN935_02730 ENOG4107Z6X Transcriptional regulator AN935_02745 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AN935_02750 ENOG41082YX Transcriptional regulator, arsr family AN935_02755 ENOG4107R5R arsenical pump membrane protein AN935_02760 ENOG4107TXC Transcriptional regulator AN935_02765 ENOG4107Y9U Membrane AN935_02775 ENOG4108SQ9 flavin reductase domain protein, FMN-binding AN935_02780 ENOG4108ZHR arsR family transcriptional regulator AN935_02785 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AN935_02795 ENOG4105ENE Histidine kinase AN935_02800 ENOG4108VB1 regulatoR AN935_02805 ENOG4105EYF MMPL domain protein AN935_02810 ENOG4108UQV Membrane AN935_02815 ENOG4108Z5V transcriptional regulator, merr family AN935_02820 ENOG41076HS cation diffusion facilitator family transporter AN935_02825 ENOG4108TVJ Nitroreductase AN935_02830 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AN935_02835 ENOG4108VGI doxx family AN935_02840 ENOG4105XXY Thioredoxin AN935_02845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AN935_02855 ENOG4105PF9 Transcriptional regulator AN935_02865 ENOG4105WQG acetyltransferase AN935_02870 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AN935_02875 ENOG4105ETE Transcriptional regulator (LacI family AN935_02880 ENOG4105C54 Major Facilitator superfamily AN935_02885 ENOG4107TRE AP endonuclease, family 2 AN935_02895 ENOG4105C85 amino acid AN935_02905 ENOG41062A4 Transcriptional regulator AN935_02910 ENOG4105EYF MMPL domain protein AN935_02920 ENOG4105CHR reductase AN935_02925 ENOG4108TVJ Nitroreductase AN935_02930 ENOG4105FS7 Transcriptional regulator AN935_02935 ENOG4108JCI Transcriptional regulator AN935_02950 ENOG4105C2C drug resistance transporter, Bcr CflA AN935_02960 ENOG4105DRR Transcriptional regulator, GntR family AN935_02965 ENOG4105VRS hydrolase family 18 AN935_02980 ENOG4105G6Z alkaline phosphatase AN935_02985 ENOG4108ZMX Domain of unknown function (DU1801) AN935_02995 ENOG4108YM7 Gcn5-related n-acetyltransferase AN935_03000 ENOG4107TVP HD domain protein AN935_03005 ENOG41090UD (LipO)protein AN935_03010 ENOG4105F27 Major Facilitator AN935_03015 ENOG4105VZJ PTS System AN935_03020 ENOG4105VCP PTS System AN935_03030 ENOG4105CS2 ec 3.2.1.21 AN935_03035 ENOG4108TZY GntR Family Transcriptional Regulator AN935_03040 ENOG4105EVU fructokinase AN935_03045 ENOG4105DG6 mannose-6-phosphate isomerase AN935_03050 ENOG4105D3P Mannan endo-1,4-beta-mannosidase AN935_03080 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AN935_03085 ENOG4105K8N protein family UPF0079, ATPase AN935_03090 ENOG41072GX Peptidase M22 Glycoprotease AN935_03095 ENOG410801F ribosomal-protein-alanine acetyltransferase AN935_03100 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AN935_03105 ENOG4105C5H ABC transporter AN935_03110 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AN935_03115 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AN935_03120 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AN935_03125 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AN935_03135 ENOG4108TYN CAAX amino terminal protease family protein AN935_03140 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AN935_03145 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AN935_03155 ENOG4105PGZ NB-ARC domain AN935_03160 ENOG4105CPQ Dehydrogenase AN935_03165 ENOG4105CT4 transporter AN935_03175 ENOG4108ZMR Ion transport 2 domain-containing protein AN935_03180 ENOG4107QNK )-transporter AN935_03210 ENOG4107YUH hydrolase AN935_03220 ENOG4107STQ Multicopper oxidase AN935_03225 ENOG4105C85 amino acid AN935_03240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AN935_03270 ENOG4105C7N Xanthine uracil vitamin C permease AN935_03295 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AN935_03300 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AN935_03305 ENOG4105C83 adenylosuccinate lyase AN935_03310 ENOG4105C8V SAICAR synthetase AN935_03315 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AN935_03320 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AN935_03325 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii AN935_03335 ENOG4105CXB phosphoribosylaminoimidazole synthetase AN935_03340 ENOG4108V3E phosphoribosylglycinamide formyltransferase AN935_03345 ENOG4105DC1 bifunctional purine biosynthesis protein purh AN935_03350 ENOG4105C12 Phosphoribosylglycinamide synthetase AN935_03360 ENOG4105DVH amino acid AN935_03375 ENOG4108R5T secreted protein AN935_03380 ENOG4105KGF protein, YerC YecD AN935_03385 ENOG4105CBC glutamate synthase AN935_03390 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) AN935_03395 ENOG4105C4R Atp-dependent dna helicase AN935_03400 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AN935_03420 ENOG4107S1E Beta-lactamase AN935_03435 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AN935_03450 ENOG4105C1G acyl-Coa dehydrogenase AN935_03480 ENOG4105CRN Aminoglycoside phosphotransferase AN935_03485 ENOG4105G6Z alkaline phosphatase AN935_03495 ENOG4105KT7 mgtC SapB transporter AN935_03500 ENOG4105CK7 Sodium proline symporter AN935_03505 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AN935_03510 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AN935_03515 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AN935_03520 ENOG4108IG5 Transcriptional regulator AN935_03530 ENOG4105CBD Diacylglycerol kinase AN935_03535 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AN935_03605 ENOG4105CDY transcriptional regulatory protein AN935_03615 ENOG4105M4P Tetr family transcriptional regulator AN935_03620 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein AN935_03625 ENOG4107S9F NmrA family AN935_03640 ENOG4105WEF catalase AN935_03645 ENOG4105M18 -acetyltransferase AN935_03660 ENOG4105C2F Histidine kinase AN935_03665 ENOG4105EQD regulatoR AN935_03670 ENOG410769Z extracellular solute-binding protein family 1 AN935_03675 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AN935_03680 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AN935_03685 ENOG4105F5H Glycosyl Hydrolase Family 88 AN935_03690 ENOG41075H3 AraC family transcriptional regulator AN935_03695 ENOG4107TDE lipolytic protein G-D-S-L family AN935_03710 ENOG4105CX8 fg-gap repeat protein AN935_03715 ENOG4105CX8 fg-gap repeat protein AN935_03720 ENOG4107TDE lipolytic protein G-D-S-L family AN935_03730 ENOG4105EKC AN935_03735 ENOG4105E0S extracellular solute-binding protein family 1 AN935_03745 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component AN935_03750 ENOG4105F8D glycoside hydrolase family 4 AN935_03755 ENOG4105H67 Protein of unknown function (DUF421) AN935_03760 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AN935_03765 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AN935_03785 ENOG4106I4J membrane AN935_03790 ENOG4108PCN EamA-like transporter family AN935_03795 ENOG41082F9 transcriptional regulator AN935_03800 ENOG41061H0 Monooxygenase AN935_03810 ENOG4108R1P AN935_03815 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AN935_03820 ENOG4105E0M Sulfatase AN935_03825 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AN935_03835 ENOG41090R9 glycosyltransferase AN935_03840 ENOG4107R51 Glycosyl transferase, family 2 AN935_03845 ENOG41090R9 glycosyltransferase AN935_03850 ENOG4105EU0 Major facilitator Superfamily AN935_03860 ENOG4105CUB amino acid AN935_03865 ENOG4105C26 Dehydrogenase AN935_03870 ENOG4105FKZ Methyl-accepting chemotaxis AN935_03875 ENOG4105C5H ABC transporter AN935_03885 ENOG4107SWG transcriptional regulator MERR family AN935_03890 ENOG4105DXB Major Facilitator superfamily AN935_03895 ENOG4105C5H ABC transporter AN935_03900 ENOG4105FDU atp-dependent rna helicase AN935_03910 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AN935_03915 ENOG4105E0A ABC, transporter AN935_03920 ENOG4108U1V ABC transporter, permease AN935_03925 ENOG4105DQ5 transport system permease protein AN935_03930 ENOG4108HUF Transporter AN935_03945 ENOG4108J20 pectate lyase AN935_03950 ENOG4107QPK )-transporter AN935_03960 ENOG4108MRH transcriptional regulatory protein AN935_03990 ENOG410855V Acylphosphatase AN935_03995 ENOG4108RPX mosc domain containing protein AN935_04015 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AN935_04045 ENOG4105C5Y PTS System AN935_04050 ENOG4105CG3 alpha amylase, catalytic region AN935_04055 ENOG4107414 GntR family transcriptional regulator AN935_04060 ENOG4108RCM Nitroreductase AN935_04065 ENOG4105CGH 5'-nucleotidase AN935_04070 ENOG4107RKG DJ-1/PfpI family AN935_04085 ENOG4105KJF protein tyrosine phosphatase AN935_04095 ENOG4107U9T Pfam:Ribonuclease_BN AN935_04105 ENOG4108ISG Major Facilitator AN935_04115 ENOG4105UPD Calcium Proton AN935_04125 ENOG4105D8X mechanosensitive ion channel AN935_04145 ENOG4106KE4 Dehydrogenase AN935_04150 ENOG4105D7N magnesium and cobalt transport protein CorA AN935_04160 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AN935_04175 ENOG4105CFC Transporter AN935_04190 ENOG4107RUY (E1 component), alpha subunit AN935_04200 ENOG4107QKR Dehydrogenase AN935_04210 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AN935_04215 ENOG41069DP small acid-soluble spore protein AN935_04220 ENOG4105KK4 UPF0060 membrane protein AN935_04245 ENOG4105F8D glycoside hydrolase family 4 AN935_04250 ENOG4108Q3X Transcriptional regulator AN935_04255 ENOG4105CI1 PTS System AN935_04260 ENOG4105BZ1 (ABC) transporter AN935_04265 ENOG4105BZ1 (ABC) transporter AN935_04275 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AN935_04280 ENOG4105ID8 Transcriptional regulator, ARAC family AN935_04285 ENOG4107QNK )-transporter AN935_04290 ENOG4107QP6 Xylose isomerase domain protein TIM barrel AN935_04295 ENOG4105CIB oxidoreductase Domain protein AN935_04300 ENOG4105BZU Histidine kinase AN935_04305 ENOG4105WH1 Two component transcriptional regulator luxr family AN935_04310 ENOG4105CJ1 ABC, transporter AN935_04315 ENOG41090VJ ABC-2 type transporter AN935_04320 ENOG4108KYE ABC-2 type transporter AN935_04330 ENOG4105U3E Transcriptional regulator AN935_04335 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold AN935_04340 ENOG4105EJ2 Transcriptional regulator AN935_04355 ENOG4105CJ1 ABC, transporter AN935_04360 ENOG4105H93 Acyltransferase family AN935_04365 ENOG4108YYS metal-dependent hydrolase (By similarity) AN935_04370 ENOG4105C0R drug resistance transporter emrb qaca subfamily AN935_04375 ENOG410834F Transcriptional regulator AN935_04385 ENOG4108MES Periplasmic binding protein AN935_04390 ENOG4105DQ5 transport system permease protein AN935_04395 ENOG4108IHU transport system permease protein AN935_04400 ENOG4105JAB phenazine biosynthesis protein, phzf family AN935_04405 ENOG4107Y03 Nitroreductase AN935_04420 ENOG4105ECP epimerase AN935_04440 ENOG4105F27 Major Facilitator AN935_04460 ENOG4106AKJ AN935_04465 ENOG4105D74 hydrolase AN935_04470 ENOG4105CKK Glycosyl transferase, family 2 AN935_04475 ENOG4105EJV Membrane AN935_04480 ENOG41067AE Membrane-bound metal-dependent hydrolase AN935_04485 ENOG4105CEN a g-specific adenine glycosylase AN935_04490 ENOG4106BXE AN935_04495 ENOG4105CAN Short-chain dehydrogenase reductase Sdr AN935_04510 ENOG4105EVI UPF0374 protein AN935_04515 ENOG4105BZ1 (ABC) transporter AN935_04520 ENOG4107NBY Membrane AN935_04530 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AN935_04535 ENOG4105G5W regulator Fur family AN935_04575 ENOG4108N23 SpoOM-related protein AN935_04590 ENOG4105EC3 peptidase S51, dipeptidase E AN935_04595 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AN935_04610 ENOG4105E2Y ABC, transporter AN935_04615 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AN935_04620 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AN935_04625 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AN935_04635 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AN935_04640 ENOG4107D63 AN935_04645 ENOG4105VZ8 Transcriptional regulator AN935_04660 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AN935_04670 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AN935_04690 ENOG4105CYN Serine protein kinase AN935_04695 ENOG4106AKX UPF0229 protein AN935_04705 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes AN935_04710 ENOG4105CW7 secretion protein, HlyD family AN935_04715 ENOG4105C0R drug resistance transporter emrb qaca subfamily AN935_04720 ENOG4105CS1 NAD(P)H quinone oxidoreductase AN935_04735 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AN935_04740 ENOG4105CZV ABC transporter AN935_04745 ENOG4105CJ1 ABC, transporter AN935_04750 ENOG4108TU7 Inherit from COG: (ABC) transporter AN935_04755 ENOG4105VEQ Cold shock protein AN935_04765 ENOG4105BZU Histidine kinase AN935_04775 ENOG4108U7W acetyltransferase AN935_04780 ENOG4108IMY Transcriptional regulator AN935_04815 ENOG4108YBP pseudouridine synthase AN935_04825 ENOG41080XP Cbs domain AN935_04830 ENOG4107YBY Hydrolase AN935_04835 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AN935_04845 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AN935_04850 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AN935_04860 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AN935_04865 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AN935_04875 ENOG4105BZU Histidine kinase AN935_04880 ENOG4105WH1 Two component transcriptional regulator luxr family AN935_04915 ENOG4105ED1 spovr family AN935_04920 ENOG4105G6Z alkaline phosphatase AN935_04935 ENOG4105BZN citrate synthase AN935_04940 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AN935_04945 ENOG4105CUB amino acid AN935_04950 ENOG4105C8J )-transporter AN935_04955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AN935_04970 ENOG4105J37 AN935_04975 ENOG4108AEY RNA polymerase sigma factor AN935_04980 ENOG4108FN7 Aldo keto reductase AN935_04985 ENOG4105F6E Acyl-transferase AN935_04990 ENOG4107VFR oxidoreductase AN935_05000 ENOG4105C37 (CBS) domain AN935_05010 ENOG4105CHM Aminotransferase AN935_05015 ENOG4105C37 (CBS) domain AN935_05025 ENOG4105WMR Protein CrcB homolog AN935_05030 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AN935_05040 ENOG4105D64 Mechanosensitive ion channel AN935_05045 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AN935_05050 ENOG4107VMI polysaccharide deacetylase AN935_05055 ENOG4105F0I Aminotransferase AN935_05075 ENOG4105BZ1 (ABC) transporter AN935_05080 ENOG4105BZ1 (ABC) transporter AN935_05100 ENOG410839P AN935_05110 ENOG4106MP8 UPF0754 membrane protein AN935_05115 ENOG4105WZB UPF0342 protein AN935_05120 ENOG4105F1N DNA alkylation repair AN935_05130 ENOG4105D4P Coproporphyrinogen iii oxidase AN935_05135 ENOG4107S91 Sodium hydrogen exchanger AN935_05140 ENOG4105NCW Trka-c domain protein AN935_05150 ENOG4105CGU Enoyl-CoA hydratase AN935_05160 ENOG4108IUX (ABC) transporter AN935_05165 ENOG4105RHA ABC transporter, permease AN935_05170 ENOG4107VRP DNA repair exonuclease AN935_05175 ENOG4106D4I domain protein AN935_05180 ENOG4105EQI Metal Dependent Phosphohydrolase AN935_05190 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AN935_05225 ENOG4105NBU tryptophan transport protein AN935_05230 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AN935_05235 ENOG4105K59 histidine triad (HIT) protein AN935_05270 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AN935_05275 ENOG4105BZ4 penicillin-binding protein AN935_05280 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AN935_05285 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AN935_05290 ENOG4105C1Q protoporphyrinogen oxidase AN935_05300 ENOG4105ECB domain protein AN935_05310 ENOG41090T1 Membrane AN935_05320 ENOG4105DER m42 family AN935_05335 ENOG4106AXD AN935_05340 ENOG4108RQ5 Beta-lactamase domain-containing protein AN935_05345 ENOG4105DF9 Lipoate-protein, ligase AN935_05355 ENOG4105CEY Amp-dependent synthetase and ligase AN935_05365 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AN935_05370 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AN935_05375 ENOG4105KD7 acetyltransferase AN935_05390 ENOG4108HUF Transporter AN935_05395 ENOG4107TB6 phosphoglycerate mutase AN935_05405 ENOG4107F3J Amp-dependent synthetase and ligase AN935_05410 ENOG4107ZYJ bioY protein AN935_05415 ENOG4106YBV Methyl-accepting chemotaxis AN935_05435 ENOG4105XVF Competence transcription factor AN935_05440 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AN935_05445 ENOG4105X3H Excalibur domain protein AN935_05450 ENOG4105E1V na solute symporter AN935_05455 ENOG4106CAD Protein of unknown function (DUF3311) AN935_05460 ENOG41060YP AN935_05475 ENOG4107SCK Monooxygenase AN935_05480 ENOG4108INS Transcriptional regulator AN935_05485 ENOG4108KK1 membrane protein AbrB duplication AN935_05490 ENOG4106K7D Major facilitator family transporter AN935_05495 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AN935_05500 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding AN935_05515 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AN935_05525 ENOG4105EYH Exonuclease AN935_05580 ENOG4105ERH Fumarylacetoacetate hydrolase AN935_05590 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AN935_05600 ENOG4105CAQ asparagine synthetase AN935_05610 ENOG4105UQX Mate efflux family protein AN935_05615 ENOG4106HBX Transcriptional Regulator AraC Family AN935_05620 ENOG4105ETE Transcriptional regulator (LacI family AN935_05625 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AN935_05630 ENOG4105SF0 DinB family AN935_05635 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AN935_05640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AN935_05645 ENOG4105MYW Pentapeptide repeat protein AN935_05650 ENOG4107S9D Alpha beta hydrolase AN935_05655 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AN935_05660 ENOG4107RIQ Sulfate adenylate transferase AN935_05665 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AN935_05670 ENOG4108N5B 2-phosphosulfolactate phosphatase AN935_05675 ENOG41061P3 phosphosulfolactate synthase AN935_05685 ENOG4105DIA mandelate racemase muconate lactonizing AN935_05690 ENOG4107RCC Major Facilitator Superfamily AN935_05695 ENOG4108SZE gCN5-related N-acetyltransferase AN935_05700 ENOG4105MA6 gCN5-related N-acetyltransferase AN935_05710 ENOG4108VPT UPF0234 protein AN935_05715 ENOG4105QNR S1 RNA binding domain protein AN935_05735 ENOG4105K7K Transcriptional regulator AN935_05745 ENOG410751J AN935_05750 ENOG4105D4Y metalloprotease AN935_05755 ENOG4105EPR degv family AN935_05760 ENOG4107AYK membrAne AN935_05770 ENOG41073B9 AN935_05780 ENOG4108KP7 hydrolase AN935_05785 ENOG4108MXZ Esterase AN935_05790 ENOG4105VG1 fes assembly suf system protein AN935_05800 ENOG4105IQ5 FAD linked oxidase domain protein AN935_05810 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AN935_05825 ENOG4105C8Y Acetylornithine aminotransferase AN935_05830 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AN935_05840 ENOG4105DBV ornithine carbamoyltransferase AN935_05865 ENOG4107RMD Basic membrane lipoprotein AN935_05880 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AN935_05885 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AN935_05895 ENOG4105C3U ABC transporter AN935_05900 ENOG4108JQ7 (ABC) transporter AN935_05915 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AN935_05925 ENOG4105C31 Tryptophanyl-tRNA synthetase AN935_05930 ENOG4108J59 Extracellular solute-binding protein, family 5 AN935_05935 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AN935_05940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AN935_05950 ENOG4108JQ7 (ABC) transporter AN935_05965 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) AN935_05970 ENOG4108ZCF integral membrane protein AN935_05975 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis AN935_05985 ENOG4105DPN Oligoendopeptidase f AN935_06000 ENOG4105T58 Dithiol-disulfide isomerase AN935_06005 ENOG4108Z18 K06886 hemoglobin AN935_06010 ENOG4105E4C Lytic transglycosylase catalytic AN935_06015 ENOG4105MIX Adenylate cyclase AN935_06030 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AN935_06035 ENOG4105EMS pseudouridine synthase AN935_06050 ENOG4105ETU transcriptional activator (TenA AN935_06055 ENOG4108VEU Thiamine monophosphate synthase AN935_06070 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AN935_06075 ENOG4105D06 uba thif-type nad fad binding protein AN935_06080 ENOG4105DWF phosphomethylpyrimidine kinase AN935_06085 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AN935_06090 ENOG4107A88 AN935_06145 ENOG4105ENA helicase AN935_06160 ENOG4108ZMI UPF0477 protein AN935_06170 ENOG4105C28 cystathionine AN935_06175 ENOG4105C28 cystathionine AN935_06180 ENOG4105D9U N-acetyltransferase AN935_06185 ENOG4105JHY Membrane AN935_06200 ENOG4108PSK reductase AN935_06215 ENOG4105DM4 PTS System AN935_06220 ENOG4105DG6 mannose-6-phosphate isomerase AN935_06235 ENOG4105VMI -acetyltransferase AN935_06245 ENOG4108Z66 YbaK ebsC protein AN935_06260 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AN935_06270 ENOG4108ZJ4 polysaccharide deacetylase AN935_06275 ENOG4107CUJ Protein of unknown function (DUF2690) AN935_06305 ENOG4108IEG Formate dehydrogenase Alpha subunit AN935_06330 ENOG4106A3M Cytochrome p-450 AN935_06335 ENOG41087PP glycosyltransferase MGT family AN935_06345 ENOG4105EXQ uroporphyrinogen iii synthase hem4 AN935_06350 ENOG4105C4B ABC transporter, permease AN935_06355 ENOG4108IXI (ABC) transporter AN935_06365 ENOG4105Q95 Cupin 2, conserved barrel domain protein AN935_06380 ENOG4105D2H Uronic isomerase AN935_06385 ENOG4105CT4 transporter AN935_06390 ENOG4105DG4 malate L-lactate dehydrogenase AN935_06395 ENOG4105CPQ Dehydrogenase AN935_06400 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AN935_06405 ENOG4105DMW Dehydrogenase reductase AN935_06410 ENOG4108I5G Major Facilitator superfamily AN935_06415 ENOG4107KJX Transcriptional regulator AN935_06420 ENOG4107QZW Altronate oxidoreductase AN935_06425 ENOG4105CTX dehydratase AN935_06430 ENOG4107TSN permease AN935_06450 ENOG41068K0 YCII-related domain AN935_06455 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AN935_06460 ENOG4105KWG Pfam:DUF1696 AN935_06465 ENOG4105K7W phage-related replication protein AN935_06470 ENOG4105WEF catalase AN935_06475 ENOG410635T phage-like element pbsx protein AN935_06525 ENOG4108TFU terminase (Small subunit) AN935_06530 ENOG4105IG6 Phage terminase, large subunit AN935_06535 ENOG4108MDF Phage Portal Protein AN935_06560 ENOG41060SN AN935_06575 ENOG4105PQS phage protein AN935_06580 ENOG4105FR7 XkdM protein, phage-like element PBSX AN935_06585 ENOG4105MTC XkdN-like protein AN935_06595 ENOG4108FKH Transglycosylase SLT domain AN935_06600 ENOG4108WZM domain protein AN935_06605 ENOG4105X7F AN935_06615 ENOG4105MFU Protein of unknown function (DUF2634) AN935_06620 ENOG41066EA baseplate J family protein AN935_06625 ENOG410906S phage-like element pbsx protein xkdt AN935_06635 ENOG41068G1 AN935_06665 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AN935_06680 ENOG4105CJ3 phosphate transporter AN935_06685 ENOG4107GRR phosphate transport regulator AN935_06690 ENOG4107R7I amino acid AN935_06700 ENOG4105EDW glycosyl transferase, family 39 AN935_06705 ENOG4105CKK Glycosyl transferase, family 2 AN935_06715 ENOG4105C0H protease AN935_06725 ENOG4108ME1 Peptidase M55 D-aminopeptidase AN935_06730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AN935_06735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AN935_06740 ENOG4105C3U ABC transporter AN935_06750 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AN935_06755 ENOG4105DTQ mandelate racemase muconate lactonizing AN935_06760 ENOG4107SN7 NLP P60 protein AN935_06765 ENOG4108JQ7 (ABC) transporter AN935_06770 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AN935_06775 ENOG4107TUM Amidinotransferase AN935_06780 ENOG4108S4H thioesterase Superfamily protein AN935_06785 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AN935_06805 ENOG4108428 Inherit from COG: -acetyltransferase AN935_06815 ENOG41080TC multidrug resistance protein AN935_06820 ENOG4105CIY formyltetrahydrofolate deformylase AN935_06825 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AN935_06840 ENOG4105K56 Transcriptional regulator AN935_06845 ENOG4108ZHJ Organic hydroperoxide resistance protein AN935_06850 ENOG4107TVC Glycosyl transferase, family 2 AN935_06855 ENOG4107Y2X deaminase AN935_06865 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AN935_06870 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AN935_06880 ENOG4108W7F transporter, permease AN935_06885 ENOG4108JJB ABC transporter AN935_06890 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein AN935_06895 ENOG4108X43 YKOF domain protein AN935_06900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AN935_06905 ENOG41062D9 Histidine kinase AN935_06915 ENOG4106849 propeptide, pepSY amd peptidase M4 AN935_06930 ENOG4105CJW magnesium transporter AN935_06935 ENOG4105V75 Transcriptional regulator AN935_06980 ENOG4105DQE DNA ligase AN935_06985 ENOG4105FDF Could be involved in DNA repair (By similarity) AN935_06990 ENOG4105BZU Histidine kinase AN935_06995 ENOG4107T5V SNARE associated Golgi AN935_07000 ENOG4107TS3 membrane protein, TerC AN935_07005 ENOG4108WZW RNA polymerase sigma AN935_07015 ENOG410681C small acid-soluble spore protein AN935_07025 ENOG4105D0M Protease HtpX homolog AN935_07045 ENOG4108TGC Acyltransferase AN935_07050 ENOG4105BZU Histidine kinase AN935_07055 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AN935_07065 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AN935_07070 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AN935_07075 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AN935_07085 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit AN935_07090 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) AN935_07095 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AN935_07100 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AN935_07120 ENOG4105BZU Histidine kinase AN935_07125 ENOG41090MY MarR family Transcriptional regulator AN935_07130 ENOG4105ER2 Ompa motb domain protein AN935_07135 ENOG4105E14 MotA TolQ exbB proton channel AN935_07145 ENOG4108K88 Membrane AN935_07150 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AN935_07155 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase AN935_07160 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AN935_07165 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AN935_07170 ENOG4105FEA Spore maturation protein AN935_07210 ENOG4105F0V Cell wall hydrolase AN935_07225 ENOG4105C59 p-type ATPase AN935_07235 ENOG4105DC7 peptidase M24 AN935_07250 ENOG4105CID antiterminator AN935_07260 ENOG4105KRI phosphocarrier protein (HPr AN935_07265 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AN935_07275 ENOG4105F6S Spore photoproduct lyase AN935_07285 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AN935_07290 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AN935_07300 ENOG4105K4I Scp-like extracellular AN935_07310 ENOG4105BZU Histidine kinase AN935_07315 ENOG4105CHM Aminotransferase AN935_07325 ENOG4107R88 Chemotaxis protein (CheV) AN935_07330 ENOG4105UIN AN935_07340 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein AN935_07350 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AN935_07355 ENOG4105EPM Diguanylate phosphodiesterase AN935_07365 ENOG4107IN1 Protein of unknown function (DUF1797) AN935_07370 ENOG4108XRC Protein of unknown function (DUF458) AN935_07400 ENOG4105NQC Flavodoxin AN935_07410 ENOG4105CH2 amidohydrolase AN935_07420 ENOG4105D8X mechanosensitive ion channel AN935_07425 ENOG4105D3R alkyl hydroperoxide reductase AN935_07430 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AN935_07445 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AN935_07450 ENOG4105D06 uba thif-type nad fad binding protein AN935_07455 ENOG4105CVM Molybdenum cofactor synthesis domain protein AN935_07460 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AN935_07465 ENOG4108ZAF Molybdopterin AN935_07470 ENOG41067WU Molybdopterin converting factor (Subunit 1) AN935_07475 ENOG4105BZ1 (ABC) transporter AN935_07480 ENOG4105BZ1 (ABC) transporter AN935_07490 ENOG4107X8C Efflux transporter RND family MFP subunit AN935_07495 ENOG4105C19 ABC transporter AN935_07500 ENOG4107RBB ABC transporter, permease AN935_07505 ENOG4105E98 transcriptional regulator DeoR family AN935_07510 ENOG4105DE4 1-phosphofructokinase AN935_07515 ENOG4105DM4 PTS System AN935_07520 ENOG4105C3F Signal peptidase i AN935_07530 ENOG4105C5H ABC transporter AN935_07535 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AN935_07560 ENOG4105BZU Histidine kinase AN935_07570 ENOG4107ZYR domain protein AN935_07580 ENOG4105CN5 Metallo-Beta-Lactamase AN935_07590 ENOG4108X4Q Hydrolase AN935_07595 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AN935_07615 ENOG4105CPP Dehydrogenase, E1 component AN935_07620 ENOG4105C7S Dehydrogenase AN935_07625 ENOG4107QN2 dihydrolipoyl dehydrogenase AN935_07635 ENOG4105CXN decarboxylase AN935_07640 ENOG4105WBI UPF0223 protein AN935_07655 ENOG4105ECY inositol monophosphatase AN935_07675 ENOG4108Z40 Transcriptional regulator AN935_07715 ENOG4105CI3 gtp-binding protein typa AN935_07720 ENOG4105QA2 AN935_07735 ENOG4108IAB Phoh family AN935_07745 ENOG4105CSV Glutaminase AN935_07750 ENOG4105ZPI UPF0358 protein AN935_07755 ENOG4105CNI cell division protein FtsW AN935_07760 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AN935_07775 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AN935_07785 ENOG4105BZ9 Cytochrome C oxidase, subunit I AN935_07790 ENOG4105CCU oxidase (Subunit III) AN935_07795 ENOG41064X9 cytochrome C oxidase subunit IV AN935_07810 ENOG41080XQ Signal transduction protein with cbs domains AN935_07815 ENOG4106UY4 Inherit from COG: Scp-like extracellular AN935_07835 ENOG4105WUC UPF0298 protein AN935_07840 ENOG4106H78 methyltransferase AN935_07845 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AN935_07850 ENOG4105H20 Sporulation integral membrane protein YlbJ AN935_07855 ENOG4105D78 K07001 NTE family protein AN935_07860 ENOG41063PX domain protein AN935_07865 ENOG4105CDE UPF0348 protein AN935_07875 ENOG4105KNH Nucleic acid-binding protein AN935_07880 ENOG41067VY 50S ribosomal protein L32 AN935_07905 ENOG4108V6E Cell division protein mraZ AN935_07910 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AN935_07920 ENOG4105CJN penicillin-binding protein AN935_07930 ENOG4105CJN penicillin-binding protein AN935_07935 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AN935_07945 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AN935_07950 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AN935_07955 ENOG4105CNI cell division protein FtsW AN935_07960 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AN935_07965 ENOG4105D4A Cell wall formation (By similarity) AN935_07970 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AN935_07975 ENOG4108R2U division initiation protein AN935_07985 ENOG4105K67 small basic protein AN935_07990 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AN935_07995 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AN935_08005 ENOG4105FFI sigma-e processing peptidase spoiiga AN935_08010 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AN935_08020 ENOG4105DKW ABC transporter AN935_08030 ENOG4105WR5 sporulation protein, YlmC YmxH family AN935_08035 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AN935_08040 ENOG4105DFA alanine racemase domain protein AN935_08045 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AN935_08050 ENOG41067XK integral membrane protein AN935_08055 ENOG4105DBK s4 domain protein AN935_08065 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AN935_08075 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AN935_08080 ENOG4105C34 Pseudouridine synthase AN935_08085 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AN935_08095 ENOG4105CXT aspartate transcarbamylase AN935_08105 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AN935_08110 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AN935_08115 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AN935_08120 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) AN935_08125 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AN935_08130 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AN935_08135 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AN935_08145 ENOG4107S4M Sulfate adenylate transferase AN935_08150 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AN935_08155 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AN935_08160 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AN935_08165 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AN935_08170 ENOG4105F23 Fibronectin-binding protein AN935_08180 ENOG4105DSJ YicC domain protein AN935_08185 ENOG4105KC4 UPF0296 protein AN935_08190 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AN935_08200 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AN935_08205 ENOG4105C25 Primosomal protein n' AN935_08210 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AN935_08215 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AN935_08220 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AN935_08225 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AN935_08230 ENOG4108ZF3 Phosphatase AN935_08235 ENOG4105D9P serine threonine protein kinase AN935_08240 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AN935_08245 ENOG4105DJV ribulose-phosphate 3-epimerase AN935_08250 ENOG4105FJ0 thiamine AN935_08260 ENOG4105VB9 50S ribosomal protein l28 AN935_08265 ENOG4108ZAA Alkaline-shock protein AN935_08270 ENOG4105DP4 dak2 domain fusion protein ylov AN935_08280 ENOG4105EJQ L-serine dehydratase AN935_08285 ENOG4105CB5 ATP-dependent DNA helicase recG AN935_08290 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) AN935_08300 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AN935_08305 ENOG4105CHR reductase AN935_08310 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AN935_08315 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AN935_08320 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AN935_08325 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AN935_08335 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) AN935_08345 ENOG4105K5M 30s ribosomal protein S16 AN935_08350 ENOG4108BW8 UPF0109 protein AN935_08360 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AN935_08365 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AN935_08370 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AN935_08375 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AN935_08380 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AN935_08390 ENOG4105VM1 flagellar AN935_08395 ENOG4105CMV Succinyl-CoA synthetase subunit beta AN935_08400 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AN935_08405 ENOG4105C79 DNA protecting protein DprA AN935_08410 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AN935_08415 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) AN935_08420 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AN935_08425 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AN935_08430 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AN935_08440 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AN935_08445 ENOG4108ZC9 flagellar basal-body rod protein flgc AN935_08450 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AN935_08455 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AN935_08460 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AN935_08475 ENOG4106YF4 Flagellar biosynthesis chaperone AN935_08485 ENOG410696Y Flagellar hook-length control protein AN935_08490 ENOG410822I Flagellar hook capping protein AN935_08495 ENOG4108JQA flagellar AN935_08500 ENOG41068WV flagellar FlbD family protein AN935_08510 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AN935_08515 ENOG4105DD5 Flagellar motor switch protein AN935_08520 ENOG4107YTP response regulator receiver protein AN935_08530 ENOG4105CN7 Flagellar biosynthetic protein FliP AN935_08535 ENOG4105VS8 Flagellar biosynthetic protein fliq AN935_08540 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AN935_08545 ENOG4105D00 flagellar biosynthetic protein flhB AN935_08550 ENOG4105D7B Flagellar biosynthesis protein flha AN935_08555 ENOG4105FZW flagellar biosynthesis regulator FlhF AN935_08565 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AN935_08570 ENOG4105CBS Chea signal transduction histidine kinase AN935_08575 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis AN935_08590 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AN935_08600 ENOG4105CE9 30S ribosomal protein S2 AN935_08605 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AN935_08615 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AN935_08620 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AN935_08625 ENOG4105KNE Phosphatidate cytidylyltransferase AN935_08635 ENOG4105DZP Membrane-associated zinc metalloprotease AN935_08640 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AN935_08645 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AN935_08650 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AN935_08655 ENOG4105CHV Transcription elongation factor NusA AN935_08660 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AN935_08665 ENOG4105VHM ribosomal protein AN935_08670 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AN935_08675 ENOG4105W7A Protein of unknown function (DUF503) AN935_08680 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AN935_08685 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AN935_08690 ENOG4105DTN riboflavin biosynthesis protein ribF AN935_08695 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AN935_08700 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AN935_08710 ENOG4105C1V Peptidase, M16 AN935_08725 ENOG4105E35 Dipicolinate synthase subunit A AN935_08730 ENOG4108S0H Dipicolinic acid synthetase, b subunit AN935_08735 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AN935_08745 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AN935_08755 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AN935_08765 ENOG4105CNU cell division protein FtsK AN935_08770 ENOG4105FDP GntR family transcriptional regulator AN935_08790 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AN935_08795 ENOG4105XZV Protein of unknown function (DUF3243) AN935_08810 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AN935_08815 ENOG4105CEV competence damage-inducible protein AN935_08825 ENOG4108A04 Beta-lactamase AN935_08830 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) AN935_08835 ENOG4105D48 metallophosphoesterase AN935_08840 ENOG4105MCT stage V sporulation protein S AN935_08850 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AN935_08855 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AN935_08870 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AN935_08875 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AN935_08905 ENOG4105IIP Membrane AN935_08910 ENOG4105W1N transcriptional regulator AN935_08925 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AN935_08935 ENOG4105K7W phage-related replication protein AN935_08940 ENOG4108X3M OsmC Ohr family protein AN935_08965 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AN935_08970 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AN935_08985 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AN935_08990 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AN935_08995 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AN935_09000 ENOG4105U6W MutT NUDIX family protein AN935_09005 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AN935_09010 ENOG4106F1P AAA ATPase, central domain protein AN935_09020 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AN935_09025 ENOG4105CXI aluminum resistance protein AN935_09030 ENOG4105KV4 Transcriptional regulator AN935_09035 ENOG4105C5F glutamine synthetase AN935_09060 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AN935_09065 ENOG4105KVH Transcriptional regulator AN935_09095 ENOG410907G AN935_09120 ENOG4105CT4 transporter AN935_09125 ENOG4105DSG hydrolase family 43 AN935_09140 ENOG4105CMG Carbohydrate kinase AN935_09150 ENOG4107Y9E nuclease AN935_09155 ENOG4105C54 Major Facilitator superfamily AN935_09165 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AN935_09235 ENOG4105CAH Chromate AN935_09245 ENOG4108Q8B Spore germination protein AN935_09250 ENOG4108NHD germination protein AN935_09265 ENOG4105FVX AN935_09275 ENOG4105K7W phage-related replication protein AN935_09285 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AN935_09295 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AN935_09305 ENOG4108SVB resolvase AN935_09310 ENOG4105VPS UPF0291 protein AN935_09315 ENOG4105CV1 Transketolase (EC 2.2.1.1) AN935_09335 ENOG4107QIV Cytochrome c biogenesis protein AN935_09360 ENOG4107DZX Small, acid-soluble spore protein P AN935_09370 ENOG4108I0Z Aconitate hydratase AN935_09375 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AN935_09390 ENOG41067CD Small, acid-soluble spore protein Tlp AN935_09400 ENOG4105MI2 AN935_09405 ENOG4105W8X HesB YadR YfhF-family protein AN935_09410 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AN935_09415 ENOG4105K4P CoA-binding domain protein AN935_09420 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AN935_09455 ENOG4108MYR Secreted protein AN935_09485 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AN935_09490 ENOG4107T5V SNARE associated Golgi AN935_09500 ENOG4107QX3 carboxylase AN935_09505 ENOG4105E39 Enoyl-CoA hydratase AN935_09510 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AN935_09515 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AN935_09520 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AN935_09525 ENOG4105CEY Amp-dependent synthetase and ligase AN935_09530 ENOG4105C1G acyl-Coa dehydrogenase AN935_09540 ENOG41062JF Transcriptional regulator AN935_09550 ENOG4105F32 YngK protein AN935_09555 ENOG4106U2H Protein of unknown function (DUF1360) AN935_09570 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family AN935_09575 ENOG4108N2V aldose 1-epimerase AN935_09580 ENOG4107QJQ Mate efflux family protein AN935_09605 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AN935_09610 ENOG4105SKE transcriptional Regulator LysR family AN935_09615 ENOG4105CB2 alcohol dehydrogenase AN935_09620 ENOG4105BZ8 glutamate synthase AN935_09625 ENOG4105CBC glutamate synthase AN935_09630 ENOG4105C5Q Transcriptional regulator AN935_09635 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AN935_09660 ENOG4108UB7 AN935_09665 ENOG41068WN AN935_09670 ENOG4105IE8 Alpha-ketoglutarate permease AN935_09675 ENOG4107U6E carbohydrate kinase FGGY AN935_09680 ENOG4108M3J Dehydrogenase AN935_09685 ENOG4108J2R molybdopterin oxidoreductase AN935_09700 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AN935_09715 ENOG4105EC8 Methyl-accepting chemotaxis AN935_09725 ENOG4108YQE rare lipoprotein a AN935_09730 ENOG4105XPP Protein of unknown function (DUF1275) AN935_09735 ENOG4108NR7 pectate lyase AN935_09755 ENOG4108RAV Conserved protein AN935_09765 ENOG4105F0F Oxalate decarboxylase AN935_09775 ENOG410780I phosphoprotein phosphatase activity AN935_09800 ENOG41073R8 VanW family AN935_09810 ENOG4105VMP Transcriptional regulator AN935_09815 ENOG4105NX3 Membrane AN935_09825 ENOG4108Q5Y Membrane AN935_09845 ENOG4108V4B ThiJ pfpI AN935_09850 ENOG4108J4B Beta-lactamase AN935_09860 ENOG4108M1A Chitin-binding protein AN935_09870 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AN935_09890 ENOG4107T94 Endo-14-beta-xylanase AN935_09895 ENOG4108J9Q DNA ligase AN935_09955 ENOG4107NTZ AN935_10000 ENOG4107R0E Glycosyl transferase, family 2 AN935_10025 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AN935_10080 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin AN935_10100 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AN935_10115 ENOG4108Z7R Chaperone CsaA AN935_10120 ENOG4105FTV AraC Family Transcriptional Regulator AN935_10125 ENOG4108HJF gCN5-related N-acetyltransferase AN935_10135 ENOG4108W8B Beta-lactamase domain protein AN935_10145 ENOG4105D29 Helix-turn-helix type 11 domain protein AN935_10155 ENOG4105KTU Transcriptional regulator, arsr family AN935_10165 ENOG4108SJC Membrane AN935_10185 ENOG4105ECK Fatty Acid Desaturase AN935_10190 ENOG4108ZGX Histidine kinase AN935_10195 ENOG4108S01 response regulator AN935_10200 ENOG41069ER domain protein AN935_10205 ENOG4105C9U ATP-dependent DNA helicase RecQ AN935_10215 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AN935_10220 ENOG4105SCY DNAK suppressor AN935_10235 ENOG4105C26 Dehydrogenase AN935_10240 ENOG4105EWU Squalene--hopene cyclase AN935_10245 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AN935_10250 ENOG4105C8J )-transporter AN935_10255 ENOG4105C09 Bile acid AN935_10260 ENOG4105C7S Dehydrogenase AN935_10270 ENOG4107T89 von Willebrand factor, type A AN935_10275 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AN935_10285 ENOG4105K4H Nlp p60 protein AN935_10290 ENOG41087PP glycosyltransferase MGT family AN935_10300 ENOG4107QMU Mate efflux family protein AN935_10305 ENOG4106SCS STAS domain AN935_10325 ENOG4105FR1 rard protein AN935_10340 ENOG4105C6Z Gluconate AN935_10345 ENOG41090U3 tautomerase AN935_10365 ENOG4105FBA Phospholipase Carboxylesterase AN935_10380 ENOG4105E1V na solute symporter AN935_10400 ENOG4108VXD carboxy-peptidase AN935_10405 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AN935_10415 ENOG4106Z5R AN935_10420 ENOG410841Q phosphoesterase PA-phosphatase related protein AN935_10455 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AN935_10460 ENOG4108TSC N-acetyltransferase AN935_10465 ENOG4107S4Y M20 DapE family protein YgeY AN935_10480 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AN935_10520 ENOG4107T32 3-phytase (EC 3.1.3.8) AN935_10525 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AN935_10535 ENOG4105E0X reductase AN935_10540 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AN935_10560 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) AN935_10565 ENOG41090WU lipolytic protein G-D-S-L family AN935_10570 ENOG4108KF3 Electron transport protein SCO1 SenC AN935_10580 ENOG4105C7B Threonine dehydratase AN935_10590 ENOG4108UT2 hemolysin iii AN935_10600 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AN935_10620 ENOG4107YX5 Pfam:DUF548 AN935_10625 ENOG4108Y6J UPF0403 protein AN935_10630 ENOG4105C01 Dihydroxy-acid dehydratase AN935_10645 ENOG4108V06 Glutathione peroxidase AN935_10650 ENOG4105CVG Homoserine O-transsuccinylase AN935_10690 ENOG41081VK Ribonuclease AN935_10715 ENOG410890F Dynamin family AN935_10725 ENOG41065KQ synthase AN935_10730 ENOG4105C2W permease AN935_10735 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AN935_10740 ENOG4105CTD carboxy-peptidase AN935_10745 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) AN935_10750 ENOG4108UHU Aldolase AN935_10755 ENOG4105D7K pfkb domain protein AN935_10760 ENOG4108M60 Transcriptional regulator AN935_10770 ENOG4105CHR reductase AN935_10775 ENOG4105DVT helicase AN935_10785 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AN935_10800 ENOG4108UKS UPF0398 protein AN935_10810 ENOG4107X2U Inherit from COG: Exonuclease-like protein AN935_10815 ENOG4108I5C dEAD DEAH box helicase AN935_10865 ENOG4105BZ4 penicillin-binding protein AN935_10875 ENOG4105CSM endonuclease III AN935_10885 ENOG4105C5S asparaginyl-tRNA synthetase AN935_10890 ENOG4105CHM Aminotransferase AN935_10900 ENOG4105YAC AN935_10905 ENOG4105DVT helicase AN935_10910 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AN935_10915 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AN935_10920 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AN935_10925 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AN935_10930 ENOG4105DJ0 Poly(A) Polymerase AN935_10935 ENOG4105CPK Glycosyl transferase (Group 1 AN935_10940 ENOG4105FJR Lmbe family AN935_10945 ENOG4108Z5K methylglyoxal synthase AN935_10950 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AN935_10955 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AN935_10960 ENOG4108JYZ YitT family AN935_10980 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AN935_11000 ENOG41068YB TPR repeat-containing protein AN935_11005 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AN935_11015 ENOG4105CIH Imidazole acetol-phosphate transaminase AN935_11025 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AN935_11030 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AN935_11040 ENOG4108I0Q anthranilate phosphoribosyltransferase AN935_11045 ENOG4105CRQ synthase (Component I) AN935_11050 ENOG4105KHN chorismate mutase AN935_11055 ENOG4105D49 3-dehydroquinate synthase AN935_11060 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AN935_11065 ENOG4105BZU Histidine kinase AN935_11070 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AN935_11075 ENOG4105EAH synthase AN935_11080 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AN935_11085 ENOG4105XXQ heptaprenyl diphosphate synthase component I AN935_11095 ENOG4105EUJ GTP cyclohydrolase i AN935_11100 ENOG4105K70 DNA-binding protein AN935_11105 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AN935_11120 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AN935_11125 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AN935_11130 ENOG41065D1 AN935_11135 ENOG4105S2F AN935_11150 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AN935_11155 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AN935_11160 ENOG4105CAT Cytidine monophosphate kinase AN935_11175 ENOG4105MSI germination protein ypeb AN935_11185 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) AN935_11190 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AN935_11205 ENOG4107RGJ metallophosphoesterase AN935_11220 ENOG4105I7S Abortive infection protein AN935_11225 ENOG4105C9U ATP-dependent DNA helicase RecQ AN935_11230 ENOG4105T7X AN935_11240 ENOG4108SAX Membrane AN935_11245 ENOG4108JQ1 Dehydrogenase AN935_11250 ENOG4105FF2 Type I DHQase AN935_11265 ENOG4105BZU Histidine kinase AN935_11270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AN935_11275 ENOG4105CRE cytochrome C AN935_11280 ENOG4107TWT Cytochrome c biogenesis protein AN935_11290 ENOG4105FE9 pseudouridine synthase AN935_11300 ENOG4108JIC nucleoside recognition domain protein AN935_11305 ENOG4105DZ1 carboxypeptidase AN935_11315 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AN935_11320 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AN935_11335 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AN935_11340 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AN935_11345 ENOG4108R6K riboflavin synthase, subunit alpha AN935_11350 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AN935_11380 ENOG4108JA1 polyketide synthase AN935_11385 ENOG4107QJQ Mate efflux family protein AN935_11390 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AN935_11400 ENOG4107QKG PfaD family AN935_11405 ENOG41062T2 Acyl carrier protein AN935_11410 ENOG4108151 Beta-lactamase domain protein AN935_11425 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase AN935_11430 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase AN935_11435 ENOG4108MGH Enoyl-CoA hydratase AN935_11440 ENOG4108KQ6 Enoyl-CoA hydratase AN935_11450 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AN935_11455 ENOG41087PP glycosyltransferase MGT family AN935_11485 ENOG4105C3F Signal peptidase i AN935_11490 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) AN935_11500 ENOG4107ZE5 PPIases accelerate the folding of proteins AN935_11510 ENOG4105PTM secreted protein AN935_11515 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AN935_11525 ENOG4105G6R Stage v sporulation protein ae AN935_11535 ENOG4105CZ3 stage V sporulation protein ad AN935_11540 ENOG41090VF Stage v sporulation protein ac AN935_11555 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AN935_11560 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AN935_11565 ENOG41082AN stage II sporulation protein AN935_11570 ENOG4105DZ1 carboxypeptidase AN935_11575 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AN935_11580 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AN935_11585 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AN935_11595 ENOG4105I3K Ferric uptake regulator, Fur family AN935_11600 ENOG4105MZ9 stage II sporulation protein m AN935_11615 ENOG4105DFD Na H antiporter AN935_11620 ENOG4108IJ0 Aspartate ammonia-lyase AN935_11625 ENOG4105HDK L-asparaginase AN935_11630 ENOG4108IMY Transcriptional regulator AN935_11640 ENOG4108YZ4 nudix hydrolase AN935_11650 ENOG4105CPC Aldo Keto reductase AN935_11670 ENOG4106HZJ AN935_11675 ENOG4105RHY Pfam:UPF0157 AN935_11680 ENOG4105KAC Antibiotic biosynthesis monooxygenase AN935_11685 ENOG4108XET gCN5-related N-acetyltransferase AN935_11695 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AN935_11730 ENOG4108IXY short-chain dehydrogenase reductase AN935_11735 ENOG41069FQ Metallo-beta-lactamase superfamily AN935_11740 ENOG4105II7 pyrroline-5-carboxylate reductase AN935_11750 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AN935_11760 ENOG410861F 50S ribosomal protein L33 AN935_11765 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AN935_11770 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AN935_11775 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AN935_11780 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AN935_11790 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) AN935_11795 ENOG4108NA0 Uncharacterized conserved protein (COG2071) AN935_11800 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AN935_11805 ENOG4108HNZ carboxyl transferase AN935_11810 ENOG4108ZVT methylmalonyl-coA epimerase AN935_11820 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AN935_11825 ENOG4108QEG Membrane AN935_11830 ENOG4105CDA abc transporter atp-binding protein AN935_11835 ENOG4105E5Q amino acid AbC transporter AN935_11840 ENOG4108HW3 (ABC) transporter AN935_11845 ENOG4108Y6J UPF0403 protein AN935_11850 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AN935_11865 ENOG4105C7S Dehydrogenase AN935_11870 ENOG4105CPP Dehydrogenase, E1 component AN935_11885 ENOG4105CKM Branched-chain carboxylic acid kinase AN935_11890 ENOG4107RDP Dehydrogenase AN935_11900 ENOG4108JUB Transcriptional regulator AN935_11905 ENOG4106CCJ Protein of unknown function (DUF2627) AN935_11910 ENOG4105CR4 methylisocitrate lyase AN935_11915 ENOG4105DXD 2-methylcitrate dehydratase AN935_11925 ENOG4105C1G acyl-Coa dehydrogenase AN935_11930 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AN935_11940 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AN935_11945 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AN935_11960 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AN935_11970 ENOG4107QQR Sporulation AN935_11980 ENOG4105S1Z Stage IV sporulation protein B AN935_11985 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AN935_11990 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AN935_11995 ENOG4105DX0 Hemolysin A AN935_12005 ENOG4105CTB Polyprenyl synthetase AN935_12010 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AN935_12015 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AN935_12020 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AN935_12025 ENOG4105M7K Involved in the transcription termination process (By similarity) AN935_12030 ENOG4108ZSR alkaline shock protein AN935_12035 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AN935_12055 ENOG410644B Stage III sporulation protein af AN935_12065 ENOG4105KQ4 Stage iii sporulation protein ad AN935_12070 ENOG4108CQH stage III sporulation protein AC AN935_12075 ENOG4105KR5 Stage iii sporulation protein AN935_12080 ENOG4105CD2 stage iii sporulation protein aa AN935_12090 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AN935_12095 ENOG4105DC7 peptidase M24 AN935_12100 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AN935_12110 ENOG4105CBJ Metal-dependent enzyme AN935_12125 ENOG4105KST dependent repressor AN935_12130 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AN935_12135 ENOG4105WZW rhodanese family AN935_12140 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AN935_12145 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AN935_12150 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AN935_12155 ENOG4105C0D helicase AN935_12170 ENOG4108IMY Transcriptional regulator AN935_12180 ENOG4105VFR signal peptidase AN935_12240 ENOG41080XP Cbs domain AN935_12250 ENOG4105C37 (CBS) domain AN935_12275 ENOG4105C5X domain protein AN935_12300 ENOG4105E0M Sulfatase AN935_12315 ENOG4107ZXI Rhomboid family AN935_12325 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AN935_12330 ENOG4105WDJ 50S ribosomal protein L33 AN935_12350 ENOG41068DG YceG-like family AN935_12355 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AN935_12360 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AN935_12365 ENOG4105E2Z phosphate ABC transporter (Permease AN935_12370 ENOG4105C8U phosphate abc transporter AN935_12375 ENOG4105CVA phosphate AN935_12380 ENOG4107RF6 penicillin-binding protein AN935_12390 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AN935_12395 ENOG4105SXS Protein of unknown function (DUF456) AN935_12410 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AN935_12415 ENOG41063Y9 AN935_12420 ENOG4108U5J '-nucleotidase AN935_12425 ENOG4105N80 Ferric uptake regulator, Fur family AN935_12430 ENOG4108JYZ YitT family AN935_12435 ENOG41069ZM Protein of unknown function (DUF2624) AN935_12440 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AN935_12455 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AN935_12460 ENOG4105EGD dinuclear metal center protein, YbgI family AN935_12475 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AN935_12480 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AN935_12485 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 AN935_12490 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AN935_12500 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AN935_12505 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AN935_12510 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) AN935_12520 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AN935_12525 ENOG4105KG3 cytidine deaminase AN935_12530 ENOG4107YR5 Diacylglycerol kinase AN935_12535 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AN935_12540 ENOG4105CTJ Metal Dependent Phosphohydrolase AN935_12550 ENOG4105C9A Phoh family AN935_12555 ENOG4105EI1 sporulation protein yqfd AN935_12560 ENOG41068P3 sporulation protein YqfC AN935_12570 ENOG4105DI5 UPF0365 protein AN935_12575 ENOG4105F7J membrane-bound serine protease AN935_12580 ENOG4105KTH gatB Yqey AN935_12595 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AN935_12600 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AN935_12605 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AN935_12610 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AN935_12615 ENOG4105CFG Acts as a chaperone (By similarity) AN935_12620 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AN935_12625 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AN935_12630 ENOG4105CSA Coproporphyrinogen iii oxidase AN935_12635 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AN935_12645 ENOG4108ZRV stage ii sporulation protein p AN935_12650 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) AN935_12655 ENOG41082YS Binds directly to 16S ribosomal RNA AN935_12660 ENOG4105TQK DNA polymerase iii, delta' subunit AN935_12670 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AN935_12675 ENOG4108UK2 deaminase AN935_12680 ENOG4105KQC Competence protein AN935_12690 ENOG4108D32 Methyltransferase AN935_12700 ENOG4108WF2 Metal Dependent Phosphohydrolase AN935_12705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AN935_12710 ENOG410812S Rna-binding protein AN935_12715 ENOG4105E2X shikimate dehydrogenase AN935_12720 ENOG4105CQW ribosome biogenesis GTPase YqeH AN935_12725 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AN935_12740 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AN935_12745 ENOG41080BT SNARE associated Golgi AN935_12760 ENOG4105WFK nuclease AN935_12765 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AN935_12780 ENOG4108HH4 Major Facilitator Superfamily AN935_12785 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AN935_12790 ENOG4108W2Y isochorismatase AN935_12805 ENOG4105DEN Luciferase family AN935_12810 ENOG41087NI Sulfite exporter TauE/SafE AN935_12815 ENOG4105VFE sira family AN935_12820 ENOG4107TPS domain protein AN935_12830 ENOG4105VFE sira family AN935_12840 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AN935_12845 ENOG4105XTG Pfam:DUF156 AN935_12860 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AN935_12865 ENOG4105UBK short-chain dehydrogenase reductase AN935_12870 ENOG4108IND Tetr family transcriptional regulator AN935_12880 ENOG4105KVH Transcriptional regulator AN935_12885 ENOG4108DBC nitroreductase AN935_12925 ENOG41067XF inhibitor AN935_12965 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AN935_12990 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family AN935_12995 ENOG4105D3P Mannan endo-1,4-beta-mannosidase AN935_13000 ENOG4108UZ3 Transporter AN935_13005 ENOG4108MCI Transcriptional regulator, ARAC family AN935_13015 ENOG4105DRR Transcriptional regulator, GntR family AN935_13030 ENOG4105DXI Major Facilitator superfamily AN935_13035 ENOG4107U9B transcriptional regulator AN935_13040 ENOG41064BW Protein of unknown function (DUF2568) AN935_13045 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AN935_13050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AN935_13055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AN935_13065 ENOG4108JQ7 (ABC) transporter AN935_13070 ENOG4105C22 threonyL-tRNA synthetase AN935_13080 ENOG4108MEK Metal-binding protein YodA AN935_13085 ENOG410904A RNA polymerase AN935_13090 ENOG4105CPC Aldo Keto reductase AN935_13095 ENOG41083Q9 chitosanase AN935_13100 ENOG4105X5K response regulator receiver protein AN935_13105 ENOG4108VQT Alpha beta hydrolase fold protein AN935_13115 ENOG4108UW5 maltose o-acetyltransferase AN935_13120 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein AN935_13125 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein AN935_13135 ENOG4105PGS Spore coat protein AN935_13140 ENOG4105E2A Dehydrogenase AN935_13155 ENOG4105KRI phosphocarrier protein (HPr AN935_13160 ENOG4105CPC Aldo Keto reductase AN935_13165 ENOG4105CF7 AraC family transcriptional regulator AN935_13170 ENOG4105VUF Transcriptional regulator AN935_13175 ENOG4105VUF Transcriptional regulator AN935_13180 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AN935_13185 ENOG4105DQ4 alcohol dehydrogenase AN935_13190 ENOG4108Z0Z intracellular protease Pfpi family AN935_13195 ENOG4108HKT sucrose-6-phosphate hydrolase AN935_13200 ENOG4105F3R pts system mannose fructose sorbose family iid AN935_13205 ENOG4105ETZ PTS System AN935_13210 ENOG4108IQ3 PTS system AN935_13215 ENOG4105YHU PTS system AN935_13220 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AN935_13230 ENOG4105C85 amino acid AN935_13235 ENOG4105N14 lysine exporter protein LysE YggA AN935_13240 ENOG4108NGU Transcriptional regulator AN935_13245 ENOG4105JVQ RNA Polymerase AN935_13250 ENOG4108P49 AntiSigma factor AN935_13255 ENOG4105EXC Acyl-transferase AN935_13260 ENOG4105WDR AN935_13265 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AN935_13270 ENOG41082JN Transcriptional regulator AN935_13285 ENOG4105TMB Formate nitrite transporter AN935_13290 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AN935_13295 ENOG4108JB9 formate dehydrogenase AN935_13310 ENOG4105C28 cystathionine AN935_13325 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AN935_13340 ENOG4107XRG penicillin-binding protein AN935_13345 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AN935_13350 ENOG4105DBI uridine monophosphokinase AN935_13355 ENOG4105CFP Peptidase U32 AN935_13360 ENOG4105XYU peptidase (U32 family) AN935_13365 ENOG4108VQJ O-methyltransferase AN935_13370 ENOG4105HHA aminodeoxychorismate lyase AN935_13375 ENOG4105VPH UPF0473 protein AN935_13380 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AN935_13385 ENOG4105VBH UPF0297 protein AN935_13390 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AN935_13395 ENOG4105C02 permease AN935_13400 ENOG4105CDA abc transporter atp-binding protein AN935_13405 ENOG4105CT1 (ABC) transporter AN935_13410 ENOG4105EAD ABC transporter AN935_13415 ENOG4105DRP amino acid AbC transporter AN935_13425 ENOG41060CR AN935_13435 ENOG4105C7H Helicase, RecD TraA family AN935_13445 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AN935_13450 ENOG4105C3J Cysteine desulfurase AN935_13460 ENOG4105D1H recombination factor protein RarA AN935_13465 ENOG4105CUZ uba thif-type nad fad binding protein AN935_13475 ENOG4105C9M aspartyl-trna synthetase AN935_13480 ENOG4105CUT histidyl-tRNA synthetase AN935_13490 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AN935_13500 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AN935_13505 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AN935_13510 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AN935_13515 ENOG41067VP Protein of unknown function (DUF1049) AN935_13520 ENOG4105NCW Trka-c domain protein AN935_13525 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AN935_13535 ENOG4105CKP Polysaccharide Biosynthesis Protein AN935_13540 ENOG4108QG2 Membrane AN935_13545 ENOG4105NAP AN935_13550 ENOG4105VIE preprotein translocase, subunit YajC AN935_13555 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AN935_13560 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AN935_13565 ENOG41061AI Protein of unknown function (DUF2905) AN935_13570 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AN935_13575 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AN935_13585 ENOG4105IE8 Alpha-ketoglutarate permease AN935_13590 ENOG4105CK5 oxidoreductase AN935_13615 ENOG4105BZG amino acid carrier protein AN935_13620 ENOG4105CDY transcriptional regulatory protein AN935_13630 ENOG4106678 morphogenetic protein associated with SpoVID AN935_13635 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AN935_13640 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AN935_13645 ENOG4108IYU L-aspartate oxidase AN935_13660 ENOG4105CQC Prephenate dehydratase AN935_13665 ENOG41090I5 UPF0735 ACT domain-containing protein AN935_13670 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AN935_13685 ENOG4105K46 50S ribosomal protein l27 AN935_13690 ENOG4105X36 (ribosomal) protein AN935_13695 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AN935_13710 ENOG4107QMS site-determining protein AN935_13715 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AN935_13720 ENOG4105YHC Rod shape-determining protein MreD AN935_13725 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AN935_13730 ENOG4105DFF Rod shape-determining protein mreb AN935_13735 ENOG4105W5Q DNA repair protein (RadC AN935_13770 ENOG410780I phosphoprotein phosphatase activity AN935_13775 ENOG4106BHF AN935_13780 ENOG4106ANW SMI1_KNR4 AN935_13785 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AN935_13805 ENOG41068G1 AN935_13815 ENOG410651K Teichoic acid biosynthesis protein C AN935_13820 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AN935_13830 ENOG4108FKH Transglycosylase SLT domain AN935_13995 ENOG4108C33 Resolvase AN935_14005 ENOG4108Z03 MAF-like protein AN935_14015 ENOG4106A3R peptidase AN935_14020 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AN935_14025 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AN935_14035 ENOG4106AR7 Spore coat protein AN935_14040 ENOG41068KH stage VI sporulation protein D AN935_14045 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AN935_14050 ENOG4105D52 delta-aminolevulinic acid dehydratase AN935_14060 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AN935_14070 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AN935_14080 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AN935_14085 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AN935_14090 ENOG4108IUQ atp-dependent protease AN935_14095 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AN935_14100 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AN935_14110 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AN935_14115 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AN935_14120 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AN935_14125 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AN935_14130 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AN935_14135 ENOG4108ZP8 Acetolactate synthase small subunit AN935_14140 ENOG4105C7K acetolactate synthase AN935_14150 ENOG4105I4A GCN5-related N-acetyltransferase AN935_14155 ENOG4107KM7 Heat induced stress protein YflT AN935_14165 ENOG4105M59 Phosphodiesterase, mj0936 family AN935_14170 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AN935_14175 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AN935_14180 ENOG4108XJQ germination protein AN935_14185 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AN935_14190 ENOG41067TZ transcriptional regulator, MarR family AN935_14195 ENOG4105PFC Transcriptional regulator AN935_14205 ENOG4105E33 succinate dehydrogenase AN935_14215 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AN935_14230 ENOG4105CFH Aspartokinase AN935_14235 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AN935_14240 ENOG4105K63 Thioredoxin AN935_14245 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) AN935_14250 ENOG4105C10 Electron transfer flavoprotein AN935_14255 ENOG4105BZJ Electron transfer flavoprotein AN935_14260 ENOG41060WC Enoyl-CoA hydratase AN935_14265 ENOG4107Z3H Transcriptional regulator, TetR family AN935_14270 ENOG4105CEY Amp-dependent synthetase and ligase AN935_14280 ENOG4105C98 muts2 protein AN935_14285 ENOG4105DCG PHP domain protein AN935_14300 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AN935_14305 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AN935_14310 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AN935_14320 ENOG4108RWN rrna methyltransferase AN935_14325 ENOG41067MF small acid-soluble spore protein AN935_14335 ENOG4105CQB FAD linked oxidase domain protein AN935_14340 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AN935_14365 ENOG4105K7K Transcriptional regulator AN935_14370 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) AN935_14375 ENOG4105DRS transport system, permease AN935_14390 ENOG4108MDK Dehydrogenase AN935_14400 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AN935_14405 ENOG4105EF1 ribulokinase AN935_14415 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase AN935_14420 ENOG4105CN9 Peptidase m42 family protein AN935_14430 ENOG410696E Membrane AN935_14435 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AN935_14440 ENOG4105VJV 50s ribosomal protein L35 AN935_14445 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AN935_14455 ENOG41067MG lrgb family AN935_14465 ENOG4105DY9 regulatoR AN935_14470 ENOG4108HRK Histidine kinase AN935_14475 ENOG4105U0R haloacid dehalogenase-like hydrolase AN935_14480 ENOG4105C22 threonyL-tRNA synthetase AN935_14485 ENOG4108TDW sporulation protein YtxC AN935_14505 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AN935_14510 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AN935_14515 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AN935_14520 ENOG4105KVH Transcriptional regulator AN935_14525 ENOG4105F27 Major Facilitator AN935_14530 ENOG4105CV8 reductase AN935_14535 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AN935_14550 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AN935_14555 ENOG4105C2M dna polymerase I AN935_14560 ENOG4105BZU Histidine kinase AN935_14565 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AN935_14570 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AN935_14575 ENOG4108HMX isocitrate dehydrogenase (NADP) AN935_14580 ENOG4105BZN citrate synthase AN935_14590 ENOG4108REF Sporulation integral membrane protein ytvi AN935_14595 ENOG4105FS0 cytoplasmic membrane protein AN935_14600 ENOG4105CA9 Pyruvate kinase AN935_14605 ENOG4105CTQ phosphohexokinase AN935_14615 ENOG4108IEY Carboxyl transferase domain AN935_14620 ENOG4105C6K Malic enzyme AN935_14625 ENOG4105C0B DNA polymerase III (alpha subunit) AN935_14630 ENOG4105VV2 AN935_14640 ENOG4106EVM AN935_14645 ENOG4105SFS phosphoesterase RecJ domain protein AN935_14665 ENOG410635A Membrane AN935_14670 ENOG4105CH2 amidohydrolase AN935_14690 ENOG4105DEN Luciferase family AN935_14695 ENOG4105CDA abc transporter atp-binding protein AN935_14720 ENOG4108XSB acetyltransferase, (GNAT) family AN935_14725 ENOG4108KSA LysR family transcriptional regulator AN935_14730 ENOG4105E8R UPF0173 metal-dependent hydrolase AN935_14745 ENOG4105CH7 arginosuccinase AN935_14750 ENOG4105CDH Citrulline--aspartate ligase AN935_14755 ENOG4105EPU Molybdenum cofactor synthesis domain protein AN935_14760 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AN935_14770 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AN935_14775 ENOG4105KBJ sporulation protein ytfj AN935_14785 ENOG4105VK3 rdd domain containing protein AN935_14790 ENOG4105D07 Signal peptide peptidase, SppA AN935_14795 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AN935_14800 ENOG4105EFZ amidohydrolase AN935_14805 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AN935_14840 ENOG4105U5Y Transcriptional regulator AN935_14850 ENOG4105BZU Histidine kinase AN935_14855 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AN935_14865 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AN935_14875 ENOG4105F1V Acetoin utilization protein AN935_14880 ENOG4105W87 Cbs domain AN935_14885 ENOG4105DGU Histone deacetylase AN935_14890 ENOG4105ER2 Ompa motb domain protein AN935_14895 ENOG4107R0U MotA TolQ exbB proton channel AN935_14900 ENOG4105ETE Transcriptional regulator (LacI family AN935_14905 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AN935_14925 ENOG4105DFU Cell wall formation (By similarity) AN935_14935 ENOG4108VDD TRNA binding domain protein AN935_14950 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ AN935_14965 ENOG4105C6K Malic enzyme AN935_14970 ENOG4105C8F Beta-lactamase domain protein AN935_14975 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AN935_14985 ENOG4108V15 phosphotransferase enzyme family AN935_14990 ENOG4108IUM Glycogen debranching enzyme AN935_15005 ENOG4107F58 2'-5' rna ligase AN935_15010 ENOG4105C6T cysteine synthase AN935_15015 ENOG4107QSE Dipeptidase AN935_15020 ENOG4105C7N Xanthine uracil vitamin C permease AN935_15035 ENOG4105YW5 deoR family transcriptional regulator AN935_15050 ENOG4105CBX hi0933 family AN935_15055 ENOG4105C94 Transporter AN935_15065 ENOG4105MU9 integral membrane protein AN935_15070 ENOG4105DDC Oxidoreductase domain protein AN935_15080 ENOG4105F5H Glycosyl Hydrolase Family 88 AN935_15090 ENOG41075H3 AraC family transcriptional regulator AN935_15100 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component AN935_15110 ENOG4106A3M Cytochrome p-450 AN935_15115 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AN935_15125 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AN935_15130 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AN935_15135 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) AN935_15145 ENOG4105NTD Inherit from COG: Hydrolase AN935_15160 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component AN935_15165 ENOG4105I1K ABC transporter AN935_15175 ENOG41085GJ domain protein AN935_15180 ENOG4105C8T Leucyl-tRNA synthetase AN935_15190 ENOG4105BZU Histidine kinase AN935_15195 ENOG410605W Major Facilitator AN935_15200 ENOG4106UBQ AN935_15210 ENOG4105C19 ABC transporter AN935_15215 ENOG4105EWM Histidine kinase AN935_15225 ENOG4107R34 abc transporter permease protein AN935_15230 ENOG4105C19 ABC transporter AN935_15245 ENOG4105DVE abc transporter atp-binding protein AN935_15250 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AN935_15265 ENOG4105N5T Radical SAM Protein AN935_15280 ENOG4105E8V Alpha Beta Hydrolase Fold protein AN935_15285 ENOG4108Z0R Transferase AN935_15290 ENOG4105C85 amino acid AN935_15295 ENOG4105CAQ asparagine synthetase AN935_15300 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AN935_15305 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AN935_15320 ENOG4105D2X ABC transporter substrate-binding protein AN935_15330 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AN935_15345 ENOG4108RMU ferritin dps family protein AN935_15360 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) AN935_15365 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AN935_15370 ENOG4108V2W Carbonate dehydratase AN935_15395 ENOG4105CC5 ABC transporter AN935_15400 ENOG4105CC5 ABC transporter AN935_15405 ENOG4105DIK (ABC) transporter AN935_15410 ENOG4105DSE periplasmic solute binding protein AN935_15415 ENOG4105DTQ mandelate racemase muconate lactonizing AN935_15420 ENOG4105CEY Amp-dependent synthetase and ligase AN935_15425 ENOG4108IPT Naphthoate synthase AN935_15430 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AN935_15435 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AN935_15440 ENOG4105E4F Isochorismate synthase AN935_15460 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AN935_15470 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AN935_15525 ENOG4105N67 Proton-coupled thiamine transporter YuaJ AN935_15530 ENOG4105VRR gCN5-related N-acetyltransferase AN935_15535 ENOG4105DZ6 Band 7 protein AN935_15545 ENOG4106DF1 AN935_15550 ENOG4108VNY MOSC domain protein AN935_15555 ENOG4108JB8 alcohol dehydrogenase AN935_15560 ENOG4105C26 Dehydrogenase AN935_15565 ENOG4105TRT Transcriptional regulator AN935_15580 ENOG4105CZN Potassium uptake protein AN935_15585 ENOG4107I77 yiaA/B two helix domain AN935_15590 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AN935_15610 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AN935_15620 ENOG4105EE0 oxidoreductase AN935_15625 ENOG4105DKG l-rhamnose isomerase AN935_15630 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) AN935_15635 ENOG4105DET Rhamnulokinase AN935_15640 ENOG4105E98 transcriptional regulator DeoR family AN935_15650 ENOG4105C8Q Methyl-accepting chemotaxis AN935_15655 ENOG4105C8Q Methyl-accepting chemotaxis AN935_15665 ENOG4105C8Q Methyl-accepting chemotaxis AN935_15680 ENOG4105EA8 2-Nitropropane dioxygenase AN935_15685 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AN935_15695 ENOG4105C37 (CBS) domain AN935_15710 ENOG4107PBV potassium channel AN935_15715 ENOG4107PBV potassium channel AN935_15730 ENOG4107QYV phosphohexose isomerase AN935_15740 ENOG4107QW4 alcohol dehydrogenase AN935_15745 ENOG4105WG9 Conserved Protein AN935_15755 ENOG4105CHM Aminotransferase AN935_15760 ENOG4108ZB6 transcriptional regulator AsnC family AN935_15765 ENOG4108MUZ hydrolase AN935_15775 ENOG4105C87 Aminotransferase class I and II AN935_15780 ENOG4108HGU Histidine kinase AN935_15785 ENOG4105Y38 Kinase-associated protein B AN935_15805 ENOG4105BZ4 penicillin-binding protein AN935_15810 ENOG4105KIR Thiol-disulfide oxidoreductase dcc AN935_15825 ENOG4108MRH transcriptional regulatory protein AN935_15830 ENOG4105DIH basic membrane AN935_15835 ENOG4108JQ9 ABC transporter AN935_15840 ENOG4105UIB (ABC) transporter AN935_15860 ENOG4105D65 subunit l AN935_15865 ENOG4105HC0 Na H antiporter AN935_15870 ENOG4108ZE9 Monovalent cation H antiporter subunit C AN935_15875 ENOG4108JPZ Monovalent cation H antiporter subunit D AN935_15880 ENOG4105SC1 monovalent cation H antiporter subunit E AN935_15890 ENOG4105KJM monovalent cation h antiporter subunit g AN935_15895 ENOG4105KA0 thioesterase Superfamily protein AN935_15905 ENOG4105BZU Histidine kinase AN935_15930 ENOG4105D58 Diguanylate phosphodiesterase AN935_15935 ENOG4105DAP Nicotinate phosphoribosyltransferase AN935_15960 ENOG4105C02 permease AN935_15980 ENOG410904N short-chain dehydrogenase reductase AN935_16015 ENOG4108K8K Transcriptional regulator AN935_16020 ENOG4105DCF alanine dehydrogenase AN935_16030 ENOG4105WQT MbtH domain protein AN935_16035 ENOG4105CEY Amp-dependent synthetase and ligase AN935_16040 ENOG4105WQI isochorismatase AN935_16045 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AN935_16050 ENOG4105E4F Isochorismate synthase AN935_16055 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AN935_16060 ENOG4105NIV Esterase AN935_16080 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AN935_16090 ENOG41069ER domain protein AN935_16105 ENOG4105CEP NADH dehydrogenase AN935_16110 ENOG4105CAY ferredoxin--nadp reductase AN935_16130 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AN935_16135 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AN935_16150 ENOG4105ZKE UPF0349 protein AN935_16165 ENOG41083MR nifu domain-containing protein AN935_16170 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AN935_16175 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AN935_16180 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AN935_16185 ENOG4105D6E homoserine dehydrogenase AN935_16195 ENOG4108W5N phosphatidylglycerophosphatase a AN935_16200 ENOG4105D4U had-superfamily hydrolase, subfamily iia AN935_16210 ENOG4105MMD transcriptional regulator AN935_16215 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AN935_16220 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AN935_16225 ENOG4105FAA peptidase M23 AN935_16230 ENOG4108YTE sporulation protein YunB AN935_16235 ENOG4105KZD Domain of unknown function (DUF1805) AN935_16240 ENOG4107R8B 5'-nucleotidase AN935_16250 ENOG4105I3N Conserved Protein AN935_16260 ENOG4105CD3 dihydroorotase AN935_16265 ENOG4105G9B Transcriptional regulator AN935_16280 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) AN935_16285 ENOG4105VT2 5-hydroxyisourate hydrolase AN935_16300 ENOG4107YV9 domain protein AN935_16305 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AN935_16320 ENOG4105XRQ Xanthine dehydrogenase accessory factor AN935_16325 ENOG4105C5R Aminotransferase AN935_16340 ENOG4108K8S endonuclease I AN935_16345 ENOG4108IJ9 (ABC) transporter AN935_16350 ENOG4105FDP GntR family transcriptional regulator AN935_16355 ENOG4108KPW sugar kinase AN935_16360 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AN935_16365 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AN935_16370 ENOG4105XN3 extracellular solute-binding protein family 1 AN935_16375 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine AN935_16380 ENOG4105PKS Excinuclease abc c subunit domain protein AN935_16385 ENOG4107VFR oxidoreductase AN935_16405 ENOG4105NPE arsR family transcriptional regulator AN935_16410 ENOG4105DIW FeS assembly protein SUFB AN935_16415 ENOG4108UNV SUF system FeS assembly protein, NifU family AN935_16420 ENOG4105C9B Cysteine desulfurase AN935_16425 ENOG4105JRK feS assembly protein SufD AN935_16430 ENOG4105C3K feS assembly ATPase SufC AN935_16445 ENOG4105D01 (LipO)protein AN935_16450 ENOG4108UMI ABC transporter, permease AN935_16455 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AN935_16480 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AN935_16485 ENOG41080E8 Transcriptional regulator, Spx MgsR family AN935_16490 ENOG4105C1G acyl-Coa dehydrogenase AN935_16495 ENOG4105CHU acetyl-coa acetyltransferase AN935_16525 ENOG41067TZ transcriptional regulator, MarR family AN935_16530 ENOG4105C0R drug resistance transporter emrb qaca subfamily AN935_16535 ENOG4105MDS 4-oxalocrotonate tautomerase AN935_16545 ENOG4105EGI Transcriptional regulator AN935_16555 ENOG4105E0A ABC, transporter AN935_16570 ENOG4105E1F short-chain dehydrogenase reductase AN935_16575 ENOG4105HUF DNA protection during starvation protein AN935_16580 ENOG4105C0H protease AN935_16590 ENOG4105F3H Histidine kinase AN935_16600 ENOG41067SE Tetr family transcriptional regulator AN935_16605 ENOG4105C9Q fumarate hydratase class II AN935_16630 ENOG4105WH1 Two component transcriptional regulator luxr family AN935_16635 ENOG4105ENE Histidine kinase AN935_16650 ENOG41087YS Phage shock protein A AN935_16665 ENOG4108WBT adenosyltransferase AN935_16670 ENOG4105E0A ABC, transporter AN935_16675 ENOG4105EHG Permease protein AN935_16680 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AN935_16685 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AN935_16690 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AN935_16700 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AN935_16710 ENOG4106DF4 Sigma-70, region 4 AN935_16720 ENOG4105F0F Oxalate decarboxylase AN935_16730 ENOG4107RBB ABC transporter, permease AN935_16735 ENOG4105C19 ABC transporter AN935_16740 ENOG4108WMK Efflux transporter RND family MFP subunit AN935_16745 ENOG4105E0A ABC, transporter AN935_16750 ENOG4105EHG Permease protein AN935_16755 ENOG4105DQ5 transport system permease protein AN935_16765 ENOG4105WAB arsR family transcriptional regulator AN935_16780 ENOG4105D5Q Arginine ornithine antiporter AN935_16790 ENOG4107K5X Membrane-bound metal-dependent hydrolase AN935_16795 ENOG4107QZ2 Sulfatase AN935_16800 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AN935_16805 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AN935_16810 ENOG4105E0C molybdate abc transporter AN935_16825 ENOG4105EEQ Na H antiporter AN935_16830 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AN935_16835 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AN935_16840 ENOG4105EEM helicase AN935_16845 ENOG4105EN6 Membrane AN935_16855 ENOG4107ZQN disulfide bond AN935_16860 ENOG4105C59 p-type ATPase AN935_16865 ENOG4105C59 p-type ATPase AN935_16870 ENOG410681U heavy metal transport detoxification protein AN935_16875 ENOG4105VPX protein, conserved in bacteria AN935_16880 ENOG4105D9R oxidoreductase AN935_16885 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AN935_16890 ENOG4105ME7 Membrane AN935_16900 ENOG4105RXJ AN935_16905 ENOG4105KPY Small multidrug resistance protein AN935_16910 ENOG4105KBX Transcriptional regulator, TetR family AN935_16915 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AN935_16935 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AN935_16940 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AN935_16950 ENOG4105XZU Preprotein translocase, subunit SecG AN935_16975 ENOG4105KVH Transcriptional regulator AN935_16980 ENOG4105C8Q Methyl-accepting chemotaxis AN935_16985 ENOG4105R40 Glycine betaine carnitine choline AN935_16990 ENOG4108HQR Glycine betaine AN935_16995 ENOG4105E90 ABC transporter AN935_17000 ENOG4108IJ8 ABC transporter AN935_17005 ENOG4107HG4 Transcriptional regulator AN935_17010 ENOG4105R40 Glycine betaine carnitine choline AN935_17015 ENOG4108HQR Glycine betaine AN935_17020 ENOG4105E90 ABC transporter AN935_17025 ENOG4108IJ8 ABC transporter AN935_17030 ENOG4107HG4 Transcriptional regulator AN935_17035 ENOG4108QCI YvbH-like oligomerisation region AN935_17045 ENOG4105T65 Membrane-associated protein AN935_17050 ENOG4108W0I acetyltransferase AN935_17055 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AN935_17060 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AN935_17065 ENOG4105CP7 Triose-phosphate isomerase AN935_17070 ENOG4105BZA Phosphoglycerate kinase AN935_17080 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AN935_17095 ENOG4105CMD Transcriptional regulator, GntR family AN935_17100 ENOG4105DEN Luciferase family AN935_17105 ENOG4105GZI Transcriptional regulator AN935_17110 ENOG4107RT3 EamA-like transporter family AN935_17120 ENOG4105VRS hydrolase family 18 AN935_17125 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AN935_17130 ENOG4107QR9 Iron-sulfur cluster binding protein AN935_17135 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AN935_17145 ENOG4105BZU Histidine kinase AN935_17150 ENOG4105KCT ABC transporter AN935_17155 ENOG4108M15 ABC transporter AN935_17160 ENOG4107R6F Alpha Beta Hydrolase Fold protein AN935_17165 ENOG4108MJI response regulator AN935_17180 ENOG4105EG2 ABC transporter, permease AN935_17190 ENOG4107FKK extracellular solute-binding protein family 1 AN935_17200 ENOG4105JXH GntR family transcriptional regulator AN935_17205 ENOG4105DAA L-lactate AN935_17210 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AN935_17220 ENOG4108ZPC Polysaccharide pyruvyl transferase AN935_17225 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AN935_17230 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family AN935_17235 ENOG4105D3Q Sugar transferase AN935_17245 ENOG4105K64 Glycosyl transferase, family 2 AN935_17255 ENOG4107QRS glycosyltransferase group 2 family protein AN935_17260 ENOG41068W6 Capsular polysaccharide biosynthesis protein AN935_17265 ENOG4108KMV Glycosyl transferase (Group 1 AN935_17270 ENOG4105K64 Glycosyl transferase, family 2 AN935_17275 ENOG4108PQP glycosyl transferase group 1 AN935_17285 ENOG4108QV3 biosynthesis protein AN935_17290 ENOG4105HTX biosynthesis protein AN935_17300 ENOG4105EBR Carboxylesterase AN935_17310 ENOG4105PY6 Phenolic acid decarboxylase AN935_17315 ENOG4105NI3 Protein of unknown function (DUF3237) AN935_17325 ENOG4105FQP Beta-lactamase AN935_17335 ENOG4105EDQ levansucrase EC 2.4.1.10 AN935_17340 ENOG4108HKT sucrose-6-phosphate hydrolase AN935_17345 ENOG4107QTZ amino acid AN935_17375 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AN935_17380 ENOG4107URF beta-phospho-glucomutase AN935_17385 ENOG4105CG3 alpha amylase, catalytic region AN935_17400 ENOG4105EG2 ABC transporter, permease AN935_17405 ENOG4105D56 permease protein AN935_17410 ENOG4107FKK extracellular solute-binding protein family 1 AN935_17415 ENOG4108IUK alpha amylase, catalytic AN935_17420 ENOG4105FKQ transcriptional regulator AN935_17425 ENOG4108URH decarboxylase AN935_17430 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain AN935_17440 ENOG4108V2W Carbonate dehydratase AN935_17445 ENOG4105C5I Dehydrogenase AN935_17455 ENOG4105C19 ABC transporter AN935_17460 ENOG4105EWM Histidine kinase AN935_17470 ENOG4107A6P AN935_17475 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AN935_17480 ENOG4105KRI phosphocarrier protein (HPr AN935_17485 ENOG4105CIE May be required for sporulation (By similarity) AN935_17490 ENOG4105CHW UPF0052 protein AN935_17495 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AN935_17500 ENOG4108Z4K mutator MutT protein AN935_17505 ENOG4105C3M thioredoxin reductase AN935_17520 ENOG4105BZ1 (ABC) transporter AN935_17540 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AN935_17545 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AN935_17550 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AN935_17555 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AN935_17560 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AN935_17565 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AN935_17570 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AN935_17575 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AN935_17585 ENOG4108E16 pectate lyase AN935_17590 ENOG4108S4C acetyltransferase AN935_17595 ENOG4107XGZ Hydrolase AN935_17600 ENOG4105HKU nucleoside recognition domain-containing protein AN935_17605 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AN935_17610 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AN935_17615 ENOG4105CE4 GlcNAc 6-P deacetylase AN935_17620 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AN935_17625 ENOG4105FDP GntR family transcriptional regulator AN935_17630 ENOG41088CQ domain protein AN935_17645 ENOG41086DT Membrane protein of unknown function AN935_17650 ENOG41067S9 phage shock protein C, PspC AN935_17655 ENOG4108PY7 AN935_17670 ENOG4105I03 Flagellin AN935_17675 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AN935_17680 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AN935_17700 ENOG4105MKU Transcriptional regulator AN935_17720 ENOG4105CN1 protease AN935_17725 ENOG4105CRP Part of the ABC transporter FtsEX involved in AN935_17730 ENOG4105CAK Cell division ATP-binding protein ftsE AN935_17745 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AN935_17755 ENOG4105MS2 ribosomal subunit Interface protein AN935_17770 ENOG4105MQ3 flagellar protein FliS AN935_17775 ENOG4107RT6 flagellar hook-associated AN935_17780 ENOG41083S7 flagellar protein FlaG AN935_17785 ENOG4105I03 Flagellin AN935_17790 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AN935_17795 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AN935_17800 ENOG4105MKD AN935_17805 ENOG4105DTJ flagellar hook-associated protein AN935_17810 ENOG4105E1Q flagellar hook-associated protein AN935_17825 ENOG4105RU3 AN935_17830 ENOG41081UC Inherit from COG: Competence protein AN935_17850 ENOG4105WH1 Two component transcriptional regulator luxr family AN935_17855 ENOG4105BZU Histidine kinase AN935_17860 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AN935_17865 ENOG4108KGH TRANSCRIPTIONal AN935_17870 ENOG4105ESV Glycosyl transferase, family 4 AN935_17875 ENOG4107EF8 Glycosyl transferase (Group 1 AN935_17890 ENOG4105QZI O-Antigen Polymerase AN935_17895 ENOG4105C6Y Udp-glucose 6-dehydrogenase AN935_17900 ENOG4107RA4 Glycosyl transferase (Group 1 AN935_17905 ENOG4105PSV Polysaccharide Biosynthesis Protein AN935_17910 ENOG4105D3Q Sugar transferase AN935_17920 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AN935_17925 ENOG4105JFG SpoIID LytB domain protein AN935_17940 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AN935_17960 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AN935_17965 ENOG4105EY8 ABC transporter AN935_17985 ENOG4105CPF Cell wall formation (By similarity) AN935_17990 ENOG4107SJB teichoic acid biosynthesis AN935_18000 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AN935_18010 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase AN935_18050 ENOG4105DG6 mannose-6-phosphate isomerase AN935_18070 ENOG4108NHD germination protein AN935_18075 ENOG4105C54 Major Facilitator superfamily AN935_18080 ENOG4108KGH TRANSCRIPTIONal AN935_18085 ENOG4105J7I hydrolase AN935_18090 ENOG4105K4H Nlp p60 protein AN935_18100 ENOG4105PNM synthesis protein AN935_18110 ENOG4105N98 Capsule biosynthesis protein capB AN935_18115 ENOG4105ETE Transcriptional regulator (LacI family AN935_18120 ENOG4108RVA ribokinase AN935_18125 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AN935_18130 ENOG4105C2J ABC transporter AN935_18135 ENOG4105CNN ABC, transporter AN935_18140 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AN935_18155 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AN935_18160 ENOG4107FQX Alpha-acetolactate decarboxylase AN935_18170 ENOG4107RSM transcriptional regulator AN935_18185 ENOG4107XC4 flavin reductase domain protein, FMN-binding AN935_18195 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AN935_18205 ENOG4105CAH Chromate AN935_18210 ENOG4105FGV Chromate AN935_18220 ENOG4108WS4 fmn reductase AN935_18225 ENOG4107V2S Transcriptional regulator AN935_18255 ENOG4105C6Y Udp-glucose 6-dehydrogenase AN935_18260 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AN935_18265 ENOG4107YJ4 chain length determinant protein AN935_18270 ENOG4105HTX biosynthesis protein AN935_18280 ENOG4105KBK Zinc finger, swim domain protein AN935_18285 ENOG4105C0D helicase AN935_18290 ENOG410667J hydrolase AN935_18295 ENOG4105E98 transcriptional regulator DeoR family AN935_18300 ENOG4105Z8H single-stranded DNA-binding protein AN935_18315 ENOG4108HWY Beta-lactamase AN935_18320 ENOG4108Z6X (sortase) family AN935_18330 ENOG4108VAC response regulator AN935_18340 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AN935_18345 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AN935_18355 ENOG4105CGA flagellar basal-body rod protein FlgG AN935_18365 ENOG4105DFF Rod shape-determining protein mreb AN935_18370 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AN935_18375 ENOG4107MII Sugar-specific transcriptional regulator TrmB AN935_18380 ENOG4105CZM Major Facilitator AN935_18385 ENOG4108M26 parallel beta-helix repeat protein AN935_18390 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AN935_18395 ENOG41080V3 Major Facilitator superfamily AN935_18400 ENOG4105D3W isochorismatase AN935_18405 ENOG4107P26 AN935_18410 ENOG4105BZU Histidine kinase AN935_18420 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AN935_18430 ENOG4105FRN stage II sporulation protein AN935_18435 ENOG4107TCE N-acetyltransferase AN935_18445 ENOG4105C5E polysaccharide biosynthesis protein AN935_18450 ENOG4105C1B dTDP-glucose 4-6-dehydratase AN935_18455 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AN935_18460 ENOG4107TY6 Acylneuraminate cytidylyltransferase AN935_18485 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AN935_18490 ENOG4107TXC Transcriptional regulator AN935_18495 ENOG4106BRK AN935_18500 ENOG4108RYK Nad-dependent epimerase dehydratase AN935_18505 ENOG4108Z40 Transcriptional regulator AN935_18510 ENOG4105CQM Urea amidohydrolase subunit alpha AN935_18515 ENOG4105KI2 Urea amidohydrolase subunit beta AN935_18520 ENOG4108YZ9 Urea amidohydrolase subunit gamma AN935_18525 ENOG4108IV0 ABC, transporter AN935_18530 ENOG4105C0Z ABC transporter AN935_18540 ENOG4105C32 Amino acid ABC transporter (Permease) AN935_18545 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AN935_18570 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AN935_18580 ENOG4108TF4 von Willebrand factor, type A AN935_18590 ENOG4105JFG SpoIID LytB domain protein AN935_18595 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AN935_18605 ENOG4106778 Protein of unknown function (DUF1146) AN935_18620 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AN935_18625 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AN935_18630 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AN935_18635 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AN935_18660 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) AN935_18670 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AN935_18675 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AN935_18680 ENOG4108UIC UPF0340 protein AN935_18685 ENOG4108YZG isomerase AN935_18690 ENOG4107WAU Protein tyrosine phosphatase AN935_18695 ENOG410815N Probably functions as a manganese efflux pump (By similarity) AN935_18700 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AN935_18710 ENOG4108ZXQ stage ii sporulation protein r AN935_18725 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AN935_18730 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AN935_18735 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AN935_18745 ENOG4107TT2 Auxin Efflux Carrier AN935_18750 ENOG4105C6K Malic enzyme AN935_18755 ENOG4107104 thymidine kinase AN935_18760 ENOG41082DI 50s ribosomal protein l31 AN935_18765 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AN935_18775 ENOG4105CBT Fructose-1,6-bisphosphatase AN935_18780 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AN935_18785 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway AN935_18790 ENOG4105D2N Aldolase AN935_18795 ENOG410812K response regulator receiver protein AN935_18805 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AN935_18815 ENOG4105C1G acyl-Coa dehydrogenase AN935_18820 ENOG4105DF6 Fe-S oxidoreductase AN935_18830 ENOG4105E5J UV damage endonuclease AN935_18840 ENOG4105NAE bifunctional deaminase-reductase domain protein AN935_18845 ENOG4105BZ1 (ABC) transporter AN935_18850 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AN935_18865 ENOG4105R3A Nitrate reductase AN935_18870 ENOG4108IUE nitrate reductase beta subunit AN935_18890 ENOG4107V6Q Cyclic nucleotide-binding domain AN935_18900 ENOG4105C75 arginyL-tRNA synthetase AN935_18905 ENOG410684U Domain of unknown function (DUF1934) AN935_18915 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E AN935_18965 ENOG4107JM4 Tetratricopeptide repeat AN935_18980 ENOG4105CYW agmatinase AN935_18985 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AN935_18990 ENOG4105BZ4 penicillin-binding protein AN935_18995 ENOG4108XFG YwhD family AN935_19000 ENOG4108Z4T Peptidase M50 AN935_19005 ENOG41069HH 4-oxalocrotonate tautomerase AN935_19010 ENOG41067TZ transcriptional regulator, MarR family AN935_19015 ENOG4105C22 threonyL-tRNA synthetase AN935_19030 ENOG41062ES Transcriptional regulator AN935_19040 ENOG4105DCI Phosphohydrolase AN935_19050 ENOG4108VCI transcription factor, rsfa family AN935_19055 ENOG4108RNG Permease of the drug metabolite transporter AN935_19065 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AN935_19070 ENOG4105DUM transcriptional regulator, lysR family AN935_19075 ENOG4108IJ2 phosphate acetyltransferase AN935_19090 ENOG4105CHM Aminotransferase AN935_19100 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase AN935_19105 ENOG4105CHR reductase AN935_19110 ENOG4106CHD Bacilysin biosynthesis protein bacB AN935_19115 ENOG41061WN bacilysin biosynthesis protein AN935_19120 ENOG4105FCW Major Facilitator superfamily AN935_19135 ENOG4105C26 Dehydrogenase AN935_19140 ENOG4105D82 Glutamate dehydrogenase AN935_19150 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase AN935_19155 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AN935_19160 ENOG4105C1B dTDP-glucose 4-6-dehydratase AN935_19165 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AN935_19170 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD AN935_19175 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AN935_19175 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AN935_19215 ENOG4105C26 Dehydrogenase AN935_19220 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AN935_19225 ENOG4108RJ9 Glycosyl transferase, family 2 AN935_19230 ENOG4105DWF phosphomethylpyrimidine kinase AN935_19245 ENOG4105C5Y PTS System AN935_19250 ENOG4108QTI )-transporter AN935_19265 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AN935_19270 ENOG4105DEN Luciferase family AN935_19275 ENOG4108DBC nitroreductase AN935_19305 ENOG4105E2S oxidase) subunit II AN935_19310 ENOG4107BMA Transglycosylase associated protein AN935_19320 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AN935_19325 ENOG4105WH5 Teichoic acid glycosylation protein AN935_19350 ENOG4107ZXU DSBA oxidoreductase AN935_19355 ENOG4105DBE peroxidase AN935_19360 ENOG410650H (LipO)protein AN935_19365 ENOG4107SJW iron permease, FTR1 AN935_19370 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AN935_19380 ENOG4105CMU LysR family (Transcriptional regulator AN935_19385 ENOG4105VAW lrga family AN935_19390 ENOG41067MG lrgb family AN935_19405 ENOG4105DR4 Methyltransferase AN935_19415 ENOG4108YV3 Protein of unknown function (DUF2711) AN935_19420 ENOG4105CK1 PTS System AN935_19425 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin AN935_19440 ENOG4105X1N Glycosyl transferase family 8 AN935_19450 ENOG4105GVJ transcriptional regulator AN935_19460 ENOG4105IIU Aminopeptidase AN935_19485 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AN935_19500 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) AN935_19505 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AN935_19515 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AN935_19520 ENOG4108VHC Short-chain dehydrogenase reductase Sdr AN935_19525 ENOG4105CM2 brancheD-chain amino acid aminotransferase AN935_19530 ENOG4105F8D glycoside hydrolase family 4 AN935_19535 ENOG4105VCP PTS System AN935_19540 ENOG4105CK1 PTS System AN935_19545 ENOG4105VZJ PTS System AN935_19550 ENOG4105EMD TRANSCRIPTIONal AN935_19560 ENOG4108VX5 3-methyladenine DNA glycosylase AN935_19565 ENOG4105CH6 catalase AN935_19580 ENOG4105DA5 (ABC) transporter AN935_19585 ENOG41069JR AN935_19605 ENOG4105ETS cytosine purines uracil thiamine allantoin AN935_19610 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AN935_19615 ENOG4108JJ8 (ABC) transporter AN935_19620 ENOG4108JJ9 ABC, transporter AN935_19625 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AN935_19630 ENOG4105C4M (Ubiquinol oxidase) subunit I AN935_19635 ENOG4105D2K citrate carrier protein AN935_19645 ENOG4107BJW polysaccharide deacetylase AN935_19670 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AN935_19680 ENOG4105CMR udp-glucose 4-epimerase AN935_19690 ENOG4105BZU Histidine kinase AN935_19695 ENOG4105WH1 Two component transcriptional regulator luxr family AN935_19700 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AN935_19730 ENOG4105DTD Dehydrogenase AN935_19735 ENOG4108IIH CoA-transferase subunit B AN935_19740 ENOG4105D6N CoA-transferase, subunit a AN935_19745 ENOG4105CY2 Citrate transporter AN935_19755 ENOG4105DHI Methyltransferase AN935_19775 ENOG4105CH6 catalase AN935_19780 ENOG4105D4T Citrate transporter AN935_19785 ENOG4108RZ2 Glycoside hydrolase family 16 AN935_19795 ENOG4105CS2 ec 3.2.1.21 AN935_19800 ENOG4105C5Y PTS System AN935_19805 ENOG4105CID antiterminator AN935_19815 ENOG4105DEU major facilitator superfamily AN935_19820 ENOG4105C1J atp-dependent rna helicase AN935_19825 ENOG4107TDE lipolytic protein G-D-S-L family AN935_19920 ENOG4107TS3 membrane protein, TerC AN935_19925 ENOG4107YZX Universal stress protein AN935_19930 ENOG4105CS2 ec 3.2.1.21 AN935_19935 ENOG4105C5Y PTS System AN935_19975 ENOG4107EV6 Inherit from COG: YD repeat protein AN935_20010 ENOG4106Z5D Glycoside Hydrolase Family 43 AN935_20025 ENOG4105C84 Histidine ammonia-lyase AN935_20030 ENOG4105CGP Urocanate hydratase AN935_20035 ENOG4105CI2 imidazolone-5-propionate hydrolase AN935_20040 ENOG4107W25 arginase agmatinase formiminoglutamase AN935_20050 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AN935_20055 ENOG4105D9N nucleoside AN935_20065 ENOG4107RHR regulatoR AN935_20070 ENOG4108TM9 integral membrane protein AN935_20075 ENOG4105ENY Ethanolamine utilization protein eutH AN935_20080 ENOG4108PGP mmge prpd family protein AN935_20085 ENOG4105CH2 amidohydrolase AN935_20095 ENOG4108HW4 amino acid AbC transporter AN935_20100 ENOG4105EAB amino acid AbC transporter AN935_20105 ENOG4108XSB acetyltransferase, (GNAT) family AN935_20110 ENOG4105CPU Monooxygenase AN935_20115 ENOG4107QHE Choloylglycine hydrolase AN935_20120 ENOG410667J hydrolase AN935_20150 ENOG4108V5C ABC transporter AN935_20180 ENOG4105D2N Aldolase AN935_20185 ENOG4107TRN Xylose isomerase domain protein TIM barrel AN935_20190 ENOG4105F0H myo-inositol catabolism protein AN935_20195 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AN935_20205 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AN935_20210 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AN935_20215 ENOG4105D7K pfkb domain protein AN935_20225 ENOG4105C26 Dehydrogenase AN935_20235 ENOG4105CPC Aldo Keto reductase AN935_20250 ENOG4105DJB Major Facilitator Superfamily AN935_20270 ENOG4107QNK )-transporter AN935_20275 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AN935_20285 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AN935_20290 ENOG4105ST3 Transcriptional regulator AN935_20295 ENOG4105C26 Dehydrogenase AN935_20305 ENOG4107SET aldo keto reductase AN935_20315 ENOG41085PJ rdd domain containing protein AN935_20330 ENOG4105J7D transcriptional regulator AN935_20335 ENOG4107JEE Short-chain dehydrogenase reductase Sdr AN935_20340 ENOG41061AU MarR family Transcriptional regulator AN935_20350 ENOG41067MG lrgb family AN935_20375 ENOG4105BZW Glycerate kinase AN935_20380 ENOG4105G3Z GntR family transcriptional regulator AN935_20385 ENOG4105CMG Carbohydrate kinase AN935_20390 ENOG4105C6Z Gluconate AN935_20395 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AN935_20400 ENOG4105D3R alkyl hydroperoxide reductase AN935_20405 ENOG4108JU3 Alkyl hydroperoxide reductase AN935_20415 ENOG4105CS2 ec 3.2.1.21 AN935_20420 ENOG4105C5Y PTS System AN935_20425 ENOG4108S3Y transcriptional regulator AN935_20430 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 AN935_20445 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AN935_20455 ENOG4105E2A Dehydrogenase AN935_20475 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) AN935_20485 ENOG410780I phosphoprotein phosphatase activity AN935_20495 ENOG41066UZ arginase EC 3.5.3.1 AN935_20500 ENOG4108IQI permease AN935_20505 ENOG4105C8Y Acetylornithine aminotransferase AN935_20510 ENOG4108JUB Transcriptional regulator AN935_20515 ENOG4105BZU Histidine kinase AN935_20540 ENOG4105C0H protease AN935_20545 ENOG4105Q2H domain protein AN935_20560 ENOG4105BZU Histidine kinase AN935_20565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AN935_20590 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AN935_20595 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AN935_20600 ENOG4105CDU Replicative dna helicase AN935_20625 ENOG4105DJ2 Major Facilitator Superfamily AN935_20630 ENOG4105EDW glycosyl transferase, family 39 AN935_20635 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AN935_20640 ENOG4105BZR domain protein AN935_20645 ENOG4108XMW Membrane AN935_20660 ENOG4105KVH Transcriptional regulator AN935_20665 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AN935_20690 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein AN935_20695 ENOG4105DDN Pentapeptide repeat-containing protein AN935_20700 ENOG4105D94 Major Facilitator Superfamily AN935_20705 ENOG4107RSM transcriptional regulator AN935_20710 ENOG41082BV acetyltransferase AN935_20720 ENOG4107V2S Transcriptional regulator AN935_20725 ENOG4108VP3 Lysine exporter protein (LysE YggA) AN935_20735 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase AN935_20745 ENOG4105KVH Transcriptional regulator AN935_20750 ENOG4108U05 Transcriptional regulator AN935_20755 ENOG41082BV acetyltransferase AN935_20775 ENOG4105UNS Pfam:DUF419 AN935_20785 ENOG4107SWG transcriptional regulator MERR family AN935_20805 ENOG41068WC Domain of unknown function (DUF955) AN935_20815 ENOG4105C7Z Conserved Protein AN935_20820 ENOG4107FCW Abortive infection protein AN935_20830 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AN935_20840 ENOG4105CGK Exodeoxyribonuclease III AN935_20845 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AN935_20850 ENOG4108UUM single-stranded DNA-binding protein AN935_20855 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AN935_20860 ENOG4105C3G gtp-binding protein AN935_20865 ENOG4108J2R molybdopterin oxidoreductase AN935_20870 ENOG4105VDK protein, conserved in bacteria AN935_20880 ENOG4108ZDA Sporulation protein YyaC AN935_20885 ENOG4105FA0 parb-like partition protein AN935_20890 ENOG4107QJE Chromosome Partitioning Protein AN935_20905 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AN935_20910 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AN935_20915 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AN935_20930 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AN935_20940 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AN935_20945 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AN935_20950 ENOG410848D S4 domain protein YaaA AN935_20965 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AN935_20970 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AN935_20985 ENOG4105DQ6 Transposase AN935_21110 ENOG4105C0W non-ribosomal peptide synthetase