locus-tag	class	description
NP436_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NP436_00010	COG0592	DNA-directed DNA polymerase activity
NP436_00015	COG2501	S4 domain
NP436_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NP436_00030	COG0187	DNA topoisomerase II activity
NP436_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP436_00070	COG0516	GMP reductase activity
NP436_00070	COG0517	IMP dehydrogenase activity
NP436_00075	COG1686	Belongs to the peptidase S11 family
NP436_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NP436_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NP436_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NP436_00100	COG1428	Deoxynucleoside kinase
NP436_00105	COG1428	Deoxynucleoside kinase
NP436_00110	COG1388	LysM domain
NP436_00110	COG3858	chitin binding
NP436_00115	COG1335	isochorismatase
NP436_00120	COG0590	tRNA wobble adenosine to inosine editing
NP436_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NP436_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NP436_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NP436_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NP436_00190	COG3853	Toxic anion resistance protein (TelA)
NP436_00195	COG1982	Orn Lys Arg decarboxylase major
NP436_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NP436_00205	COG3870	Protein conserved in bacteria
NP436_00210	COG1728	Protein conserved in bacteria
NP436_00215	COG0470	DNA polymerase III
NP436_00220	COG1774	PSP1 C-terminal conserved region
NP436_00225	COG4467	Involved in initiation control of chromosome replication
NP436_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NP436_00235	COG2827	Endonuclease containing a URI domain
NP436_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NP436_00245	COG2002	toxin-antitoxin pair type II binding
NP436_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP436_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP436_00255	COG0084	hydrolase, TatD family'
NP436_00260	COG3583	domain protein
NP436_00260	COG3584	3D domain protein
NP436_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP436_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NP436_00280	COG4466	Protein conserved in bacteria
NP436_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NP436_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP436_00300	COG0251	oxidation-reduction process
NP436_00305	COG2088	sporulation resulting in formation of a cellular spore
NP436_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NP436_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NP436_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NP436_00325	COG0193	aminoacyl-tRNA hydrolase activity
NP436_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NP436_00340	COG2002	toxin-antitoxin pair type II binding
NP436_00345	COG2244	polysaccharide biosynthetic process
NP436_00350	COG3956	TIGRFAM MazG family protein
NP436_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NP436_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NP436_00375	COG1098	S1 RNA binding domain
NP436_00390	COG2208	phosphoserine phosphatase activity
NP436_00395	COG2304	oxidoreductase activity
NP436_00400	COG0515	serine threonine protein kinase
NP436_00405	COG0037	tRNA processing
NP436_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NP436_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP436_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NP436_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NP436_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP436_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP436_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP436_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
NP436_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP436_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NP436_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NP436_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP436_00475	COG1396	sequence-specific DNA binding
NP436_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP436_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NP436_00565	COG4463	regulation of RNA biosynthetic process
NP436_00570	COG3880	PFAM UvrB UvrC protein
NP436_00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
NP436_00580	COG0542	response to heat
NP436_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NP436_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NP436_00595	COG4956	integral membrane protein (PIN domain superfamily)
NP436_00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NP436_00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NP436_00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP436_00615	COG1045	serine acetyltransferase
NP436_00620	COG0215	cysteine-tRNA ligase activity
NP436_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NP436_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP436_00635	COG3688	RNA-binding protein containing a PIN domain
NP436_00640	COG1595	DNA-templated transcription, initiation
NP436_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP436_00655	COG0250	Participates in transcription elongation, termination and antitermination
NP436_00665	COG0081	regulation of translation
NP436_00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NP436_00680	COG2813	Specifically methylates the guanine in position
NP436_00685	COG0085	RNA polymerase activity
NP436_00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NP436_00695	COG1358	cellular component organization or biogenesis
NP436_00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NP436_00705	COG0049	tRNA binding
NP436_00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP436_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NP436_00720	COG0596	Alpha beta hydrolase
NP436_00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NP436_00735	COG0088	Forms part of the polypeptide exit tunnel
NP436_00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NP436_00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NP436_00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NP436_00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NP436_00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NP436_00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NP436_00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NP436_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NP436_00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NP436_00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NP436_00825	COG0200	Binds to the 23S rRNA
NP436_00830	COG0201	protein transport
NP436_00835	COG0563	adenylate kinase activity
NP436_00840	COG0024	Methionine aminopeptidase
NP436_00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
NP436_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NP436_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NP436_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NP436_00870	COG0202	RNA polymerase activity
NP436_00875	COG0203	ribosomal protein L17
NP436_00880	COG1122	ATPase activity
NP436_00885	COG1122	ATPase activity
NP436_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP436_00895	COG0101	tRNA pseudouridine synthase activity
NP436_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NP436_00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NP436_00910	COG2226	methyltransferase
NP436_00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP436_00925	COG0489	protein tyrosine kinase activity
NP436_00935	COG2194	sulfuric ester hydrolase activity
NP436_00940	COG0726	polysaccharide deacetylase
NP436_01025	COG0659	secondary active sulfate transmembrane transporter activity
NP436_01030	COG0385	Bile acid
NP436_01035	COG2819	hydrolase of the alpha beta superfamily
NP436_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP436_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP436_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP436_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP436_01055	COG2207	Transcriptional regulator
NP436_01060	COG3876	Protein conserved in bacteria
NP436_01065	COG1472	Belongs to the glycosyl hydrolase 3 family
NP436_01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP436_01075	COG1263	PTS System
NP436_01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_01080	COG1737	Transcriptional regulator
NP436_01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NP436_01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP436_01095	COG1683	Conserved Protein
NP436_01125	COG1595	DNA-templated transcription, initiation
NP436_01130	COG5662	AntiSigma factor
NP436_01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP436_01140	COG4856	YbbR-like protein
NP436_01145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP436_01150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NP436_01165	COG2169	Transcriptional regulator
NP436_01170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP436_01175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP436_01180	COG3002	Belongs to the UPF0753 family
NP436_01185	COG0288	reversible hydration of carbon dioxide
NP436_01195	COG5609	conserved protein (DUF2294)
NP436_01205	COG0642	Histidine kinase
NP436_01215	COG0515	serine threonine protein kinase
NP436_01230	COG1113	amino acid transport
NP436_01245	COG2602	Beta-lactamase
NP436_01250	COG2124	cytochrome p450
NP436_01260	COG0531	amino acid
NP436_01265	COG0584	glycerophosphoryl diester phosphodiesterase
NP436_01270	COG2271	Major facilitator Superfamily
NP436_01280	COG0456	acetyltransferase
NP436_01280	COG1846	Transcriptional regulator
NP436_01295	COG3409	Peptidoglycan-binding domain 1 protein
NP436_01300	COG0697	spore germination
NP436_01305	COG1917	Cupin 2, conserved barrel domain protein
NP436_01305	COG2207	Transcriptional regulator
NP436_01330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NP436_01335	COG3591	Belongs to the peptidase S1B family
NP436_01345	COG0596	Alpha beta hydrolase
NP436_01350	COG1183	phosphatidylcholine synthase activity
NP436_01355	COG0586	Pfam SNARE associated Golgi protein
NP436_01360	COG0688	phosphatidylethanolamine metabolic process
NP436_01370	COG2312	Erythromycin esterase
NP436_01375	COG2207	Transcriptional regulator
NP436_01380	COG1054	Belongs to the UPF0176 family
NP436_01385	COG1301	dicarboxylic acid transport
NP436_01390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_01390	COG2190	(PTS) system
NP436_01390	COG1263	PTS System
NP436_01395	COG0363	glucosamine-6-phosphate deaminase activity
NP436_01400	COG2188	Transcriptional regulator
NP436_01410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP436_01415	COG0833	amino acid
NP436_01420	COG2040	homocysteine
NP436_01430	COG2066	Belongs to the glutaminase family
NP436_01435	COG4191	Histidine kinase
NP436_01440	COG0784	Response regulator, receiver
NP436_01445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP436_01450	COG1012	belongs to the aldehyde dehydrogenase family
NP436_01455	COG2271	Major facilitator Superfamily
NP436_01460	COG4948	Mandelate Racemase Muconate Lactonizing
NP436_01465	COG2186	Transcriptional regulator
NP436_01470	COG2721	sulfolactate sulfo-lyase activity
NP436_01475	COG3173	Aminoglycoside phosphotransferase
NP436_01485	COG0697	spore germination
NP436_01490	COG0745	RESPONSE REGULATOR receiver
NP436_01495	COG2205	protein histidine kinase activity
NP436_01500	COG1131	(ABC) transporter
NP436_01520	COG3773	Cell wall hydrolase
NP436_01525	COG2304	oxidoreductase activity
NP436_01535	COG3540	Alkaline phosphatase
NP436_01540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP436_01545	COG0805	protein transport
NP436_01550	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NP436_01555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP436_01560	COG0477	Major facilitator Superfamily
NP436_01565	COG1309	transcriptional regulator
NP436_01570	COG0252	asparaginase activity
NP436_01575	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NP436_01580	COG1714	RDD family
NP436_01585	COG1405	negative regulation of cell septum assembly
NP436_01585	COG3012	SEC-C Motif Domain Protein
NP436_01595	COG3279	Response regulator of the LytR AlgR family
NP436_01605	COG1668	transmembrane transport
NP436_01610	COG0667	Aldo Keto reductase
NP436_01625	COG1595	DNA-templated transcription, initiation
NP436_01630	COG1595	DNA-templated transcription, initiation
NP436_01635	COG1876	peptidase activity
NP436_01645	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_01650	COG0366	Alpha amylase catalytic
NP436_01655	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP436_01660	COG1121	(ABC) transporter
NP436_01665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP436_01675	COG2310	stress, protein
NP436_01680	COG2310	stress, protein
NP436_01685	COG2310	stress, protein
NP436_01690	COG0861	Integral membrane protein TerC family
NP436_01700	COG3853	Toxic anion resistance protein (TelA)
NP436_01710	COG0477	Major facilitator Superfamily
NP436_01715	COG2814	Major facilitator Superfamily
NP436_01720	COG0640	Transcriptional regulator
NP436_01725	COG0517	IMP dehydrogenase activity
NP436_01725	COG4175	Glycine betaine
NP436_01730	COG4176	ABC-type proline glycine betaine transport system permease component
NP436_01735	COG2113	Glycine betaine
NP436_01740	COG1473	amidohydrolase
NP436_01745	COG1288	antiporter activity
NP436_01760	COG0039	L-malate dehydrogenase activity
NP436_01775	COG3403	YqcI/YcgG family
NP436_01790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NP436_01795	COG1660	Displays ATPase and GTPase activities
NP436_01800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NP436_01810	COG2226	methyltransferase
NP436_01815	COG0583	DNA-binding transcription factor activity
NP436_01820	COG3458	cephalosporin-C deacetylase activity
NP436_01825	COG3541	Predicted nucleotidyltransferase
NP436_01830	COG0506	proline dehydrogenase activity
NP436_01835	COG1012	belongs to the aldehyde dehydrogenase family
NP436_01840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP436_01845	COG2508	Transcriptional regulator
NP436_01850	COG3689	TIGRFAM TIGR03943 family protein
NP436_01855	COG0701	Predicted permease
NP436_01860	COG2267	carboxylic ester hydrolase activity
NP436_01865	COG0492	ferredoxin-NADP+ reductase activity
NP436_01870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP436_01870	COG1587	Uroporphyrinogen-III synthase
NP436_01875	COG2146	nitrite reductase [NAD(P)H] activity
NP436_01880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP436_01885	COG0243	molybdopterin cofactor binding
NP436_01890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP436_01895	COG2223	nitrite transmembrane transporter activity
NP436_01905	COG1376	ErfK ybiS ycfS ynhG family protein
NP436_01920	COG0765	amino acid transport
NP436_01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP436_01935	COG1714	RDD family
NP436_01945	COG1846	Transcriptional regulator
NP436_01960	COG2723	6-phospho-beta-galactosidase activity
NP436_01970	COG3209	COG3209 Rhs family protein
NP436_01980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NP436_01985	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NP436_01990	COG1733	regulation of RNA biosynthetic process
NP436_01995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP436_02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP436_02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP436_02025	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NP436_02030	COG2814	Major facilitator Superfamily
NP436_02040	COG0697	spore germination
NP436_02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP436_02055	COG2364	Membrane
NP436_02060	COG1126	abc transporter atp-binding protein
NP436_02065	COG0765	amino acid transport
NP436_02070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP436_02075	COG0583	DNA-binding transcription factor activity
NP436_02080	COG0163	prenyltransferase activity
NP436_02085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NP436_02100	COG0596	Alpha beta hydrolase
NP436_02105	COG3104	oligopeptide transport
NP436_02110	COG5434	Belongs to the glycosyl hydrolase 28 family
NP436_02120	COG0697	spore germination
NP436_02130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NP436_02135	COG1136	(ABC) transporter
NP436_02140	COG0577	efflux transmembrane transporter activity
NP436_02145	COG0745	RESPONSE REGULATOR receiver
NP436_02150	COG3850	Histidine kinase
NP436_02150	COG5002	protein histidine kinase activity
NP436_02155	COG0457	Tetratricopeptide repeat
NP436_02175	COG0527	aspartate kinase activity
NP436_02180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP436_02185	COG4605	iron ion homeostasis
NP436_02190	COG4604	ABC transporter, ATP-binding protein
NP436_02195	COG4607	ABC-type enterochelin transport system periplasmic component
NP436_02205	COG2814	Major facilitator Superfamily
NP436_02210	COG1309	transcriptional regulator
NP436_02215	COG0778	Nitroreductase
NP436_02220	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NP436_02225	COG0640	Transcriptional regulator
NP436_02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP436_02235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP436_02240	COG1012	belongs to the aldehyde dehydrogenase family
NP436_02245	COG4975	Glucose uptake
NP436_02250	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_02255	COG4549	nuclear export factor GLE1
NP436_02260	COG2372	response to copper ion
NP436_02260	COG1276	copper resistance
NP436_02265	COG1349	DNA-binding transcription factor activity
NP436_02275	COG2213	PTS system mannitol-specific
NP436_02280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP436_02285	COG0246	Mannitol dehydrogenase
NP436_02290	COG0473	3-isopropylmalate dehydrogenase activity
NP436_02295	COG0681	Belongs to the peptidase S26 family
NP436_02305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP436_02320	COG0561	phosphatase activity
NP436_02325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NP436_02330	COG1914	H( )-stimulated, divalent metal cation uptake system
NP436_02335	COG4336	lyase activity
NP436_02340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NP436_02345	COG1984	allophanate hydrolase subunit 2
NP436_02350	COG1414	Transcriptional regulator
NP436_02355	COG2755	lipolytic protein G-D-S-L family
NP436_02365	COG2329	Antibiotic biosynthesis monooxygenase
NP436_02370	COG0768	penicillin binding
NP436_02375	COG4989	oxidoreductase activity
NP436_02380	COG3711	transcriptional antiterminator
NP436_02385	COG0318	PFAM AMP-dependent synthetase and ligase
NP436_02390	COG2226	methyltransferase
NP436_02395	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_02400	COG1917	Cupin 2, conserved barrel domain protein
NP436_02405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP436_02410	COG3871	stress protein (general stress protein 26)
NP436_02420	COG2814	Major facilitator Superfamily
NP436_02425	COG1522	sequence-specific DNA binding
NP436_02430	COG0551	DNA topoisomerase type I activity
NP436_02430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP436_02435	COG0494	nUDIX hydrolase
NP436_02440	COG0028	Belongs to the TPP enzyme family
NP436_02465	COG1914	H( )-stimulated, divalent metal cation uptake system
NP436_02470	COG2261	transglycosylase associated protein
NP436_02475	COG4876	unkown
NP436_02480	COG2217	Heavy metal translocating P-type atpase
NP436_02485	COG3729	General stress protein
NP436_02490	COG0662	Cupin 2, conserved barrel domain protein
NP436_02495	COG2329	Antibiotic biosynthesis monooxygenase
NP436_02500	COG3546	catalase activity
NP436_02505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP436_02510	COG3290	protein histidine kinase activity
NP436_02515	COG4565	transcriptional regulatory protein
NP436_02520	COG1301	dicarboxylic acid transport
NP436_02525	COG0628	permease
NP436_02535	COG1131	(ABC) transporter
NP436_02540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP436_02550	COG1960	acyl-CoA dehydrogenase activity
NP436_02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP436_02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP436_02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
NP436_02580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NP436_02585	COG0513	Belongs to the DEAD box helicase family
NP436_02590	COG3402	PFAM membrane-flanked domain
NP436_02595	COG3428	Bacterial PH domain
NP436_02600	COG0705	Rhomboid family
NP436_02605	COG0736	holo-[acyl-carrier-protein] synthase activity
NP436_02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NP436_02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP436_02620	COG0864	Transcriptional regulator
NP436_02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
NP436_02630	COG1366	Belongs to the anti-sigma-factor antagonist family
NP436_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
NP436_02640	COG2172	sigma factor antagonist activity
NP436_02645	COG2208	phosphoserine phosphatase activity
NP436_02650	COG1366	Belongs to the anti-sigma-factor antagonist family
NP436_02655	COG2172	sigma factor antagonist activity
NP436_02660	COG1191	sigma factor activity
NP436_02665	COG2208	phosphoserine phosphatase activity
NP436_02680	COG1673	EVE domain
NP436_02685	COG1846	Transcriptional regulator
NP436_02690	COG2183	response to ionizing radiation
NP436_02700	COG3091	SprT-like family
NP436_02740	COG0582	viral genome integration into host DNA
NP436_02745	COG2856	Zn peptidase
NP436_02750	COG1396	sequence-specific DNA binding
NP436_02780	COG1674	ftsk spoiiie
NP436_02785	COG2946	Replication initiation factor
NP436_02825	COG0433	COG0433 Predicted ATPase
NP436_02835	COG5644	endopeptidase inhibitor activity
NP436_02845	COG0741	lytic transglycosylase activity
NP436_02845	COG0791	NLP P60 protein
NP436_02860	COG0457	Tetratricopeptide repeat
NP436_02900	COG0583	DNA-binding transcription factor activity
NP436_02905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP436_02915	COG5444	nuclease activity
NP436_02920	COG1476	TRANSCRIPTIONal
NP436_02945	COG0693	protein deglycase activity
NP436_02950	COG1278	Cold shock
NP436_02955	COG1329	Transcriptional regulator
NP436_02960	COG0697	spore germination
NP436_02965	COG1917	Cupin 2, conserved barrel domain protein
NP436_02965	COG2207	Transcriptional regulator
NP436_02975	COG3708	Transcriptional regulator
NP436_02975	COG2207	Transcriptional regulator
NP436_02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP436_02995	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
NP436_03010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP436_03015	COG1309	transcriptional regulator
NP436_03020	COG0697	spore germination
NP436_03025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP436_03030	COG2030	dehydratase
NP436_03035	COG3545	Serine hydrolase
NP436_03045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP436_03050	COG0640	Transcriptional regulator
NP436_03055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP436_03065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP436_03070	COG0697	spore germination
NP436_03075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP436_03080	COG0076	glutamate decarboxylase activity
NP436_03085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP436_03090	COG0640	Transcriptional regulator
NP436_03095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NP436_03110	COG4585	Histidine kinase
NP436_03115	COG2197	response regulator
NP436_03120	COG2409	Drug exporters of the RND superfamily
NP436_03125	COG0596	Alpha beta hydrolase
NP436_03130	COG1811	Na channel or pump
NP436_03135	COG4978	Transcriptional regulator
NP436_03135	COG0789	Transcriptional regulator
NP436_03140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP436_03145	COG0778	Nitroreductase
NP436_03150	COG0346	lactoylglutathione lyase activity
NP436_03155	COG2259	Doxx family
NP436_03160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP436_03190	COG2323	membrane
NP436_03195	COG0071	Belongs to the small heat shock protein (HSP20) family
NP436_03210	COG1309	transcriptional regulator
NP436_03220	COG0456	acetyltransferase
NP436_03230	COG0488	(ABC) transporter
NP436_03235	COG1113	amino acid transport
NP436_03240	COG2318	DinB family
NP436_03245	COG1846	Transcriptional regulator
NP436_03250	COG2409	Drug exporters of the RND superfamily
NP436_03250	COG1033	growth of symbiont in host cell
NP436_03255	COG0778	Nitroreductase
NP436_03260	COG1846	Transcriptional regulator
NP436_03265	COG2814	Major facilitator Superfamily
NP436_03270	COG0730	response to heat
NP436_03275	COG1802	Transcriptional regulator
NP436_03280	COG3858	chitin binding
NP436_03280	COG1388	LysM domain
NP436_03285	COG1819	glycosyl
NP436_03295	COG1785	Belongs to the alkaline phosphatase family
NP436_03300	COG5646	InterPro IPR014922
NP436_03310	COG0454	-acetyltransferase
NP436_03315	COG1078	dGTPase activity
NP436_03320	COG1388	LysM domain
NP436_03325	COG2814	Major facilitator Superfamily
NP436_03330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP436_03345	COG2723	6-phospho-beta-galactosidase activity
NP436_03350	COG2188	Transcriptional regulator
NP436_03355	COG1940	carbohydrate kinase activity
NP436_03365	COG4124	Belongs to the glycosyl hydrolase 26 family
NP436_03410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NP436_03415	COG0802	atpase or kinase
NP436_03420	COG1214	PFAM Peptidase M22, glycoprotease
NP436_03425	COG0456	acetyltransferase
NP436_03430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NP436_03435	COG0488	(ABC) transporter
NP436_03440	COG0315	cyclic pyranopterin monophosphate synthase activity
NP436_03445	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NP436_03450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP436_03455	COG0805	protein transport
NP436_03465	COG1266	CAAX protease self-immunity
NP436_03475	COG0459	protein refolding
NP436_03495	COG0457	Tetratricopeptide repeat
NP436_03500	COG1063	alcohol dehydrogenase
NP436_03505	COG2211	Major facilitator Superfamily
NP436_03510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP436_03520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP436_03525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NP436_03530	COG4260	virion core protein, lumpy skin disease virus
NP436_03540	COG2814	Major facilitator Superfamily
NP436_03545	COG1063	alcohol dehydrogenase
NP436_03550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NP436_03555	COG0823	Involved in the tonB-independent uptake of proteins
NP436_03575	COG2267	carboxylic ester hydrolase activity
NP436_03585	COG2132	Multicopper oxidase
NP436_03590	COG1113	amino acid transport
NP436_03600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP436_03605	COG0714	Associated with various cellular activities
NP436_03610	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NP436_03615	COG1305	Transglutaminase-like
NP436_03620	COG0519	Catalyzes the synthesis of GMP from XMP
NP436_03620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NP436_03630	COG2252	PERMEase
NP436_03635	COG3064	Membrane
NP436_03645	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
NP436_03655	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NP436_03660	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NP436_03665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NP436_03670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NP436_03675	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP436_03680	COG0047	phosphoribosylformylglycinamidine synthase activity
NP436_03685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP436_03690	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NP436_03695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NP436_03700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NP436_03705	COG0138	bifunctional purine biosynthesis protein purh
NP436_03710	COG0151	Belongs to the GarS family
NP436_03715	COG1522	sequence-specific DNA binding
NP436_03720	COG0531	amino acid
NP436_03730	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP436_03735	COG1470	cell adhesion involved in biofilm formation
NP436_03740	COG4496	protein, YerC YecD
NP436_03745	COG0069	glutamate synthase activity
NP436_03750	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NP436_03755	COG0210	DNA helicase
NP436_03760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NP436_03765	COG4851	CamS sex pheromone cAM373 precursor
NP436_03775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP436_03780	COG1285	pathogenesis
NP436_03785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP436_03790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP436_03795	COG0154	amidase activity
NP436_03800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP436_03810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP436_03815	COG1597	lipid kinase activity
NP436_03820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP436_03825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP436_03850	COG5444	nuclease activity
NP436_03860	COG0457	Tetratricopeptide repeat
NP436_03870	COG0217	transcriptional regulatory protein
NP436_03880	COG1309	transcriptional regulator
NP436_03895	COG3546	catalase activity
NP436_03900	COG0454	-acetyltransferase
NP436_03910	COG5578	integral membrane protein
NP436_03915	COG2972	Histidine kinase
NP436_03925	COG1653	transport
NP436_03930	COG1175	transmembrane transport
NP436_03935	COG0395	ABC-type sugar transport system, permease component
NP436_03940	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NP436_03945	COG2207	Transcriptional regulator
NP436_03950	COG2755	lipolytic protein G-D-S-L family
NP436_03960	COG5578	integral membrane protein
NP436_03965	COG3401	FG-GAP repeat protein
NP436_03970	COG3401	FG-GAP repeat protein
NP436_03975	COG2755	lipolytic protein G-D-S-L family
NP436_03990	COG1653	transport
NP436_03995	COG4209	transmembrane transport
NP436_04000	COG0395	ABC-type sugar transport system, permease component
NP436_04005	COG1486	melibiose metabolic process
NP436_04010	COG2323	membrane
NP436_04015	COG2329	Antibiotic biosynthesis monooxygenase
NP436_04020	COG0346	lactoylglutathione lyase activity
NP436_04035	COG5583	Uncharacterized small protein (DUF2292)
NP436_04040	COG0670	Belongs to the BI1 family
NP436_04055	COG3328	transposase activity
NP436_04065	COG2124	cytochrome p450
NP436_04065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP436_04070	COG1368	sulfuric ester hydrolase activity
NP436_04075	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NP436_04080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP436_04085	COG1442	glycosyl transferase family 8
NP436_04090	COG1216	Glycosyl transferase, family 2
NP436_04095	COG1442	glycosyl transferase family 8
NP436_04100	COG2223	nitrite transmembrane transporter activity
NP436_04105	COG1011	Hydrolase
NP436_04110	COG0531	amino acid
NP436_04115	COG1012	belongs to the aldehyde dehydrogenase family
NP436_04120	COG0840	transmembrane signaling receptor activity
NP436_04125	COG0488	(ABC) transporter
NP436_04135	COG0789	Transcriptional regulator
NP436_04140	COG2814	Major facilitator Superfamily
NP436_04160	COG0488	(ABC) transporter
NP436_04165	COG0513	Belongs to the DEAD box helicase family
NP436_04175	COG3866	Pectate lyase
NP436_04180	COG0471	metal ion transport
NP436_04185	COG3290	protein histidine kinase activity
NP436_04190	COG4565	transcriptional regulatory protein
NP436_04195	COG3181	Tripartite tricarboxylate transporter family receptor
NP436_04205	COG2851	Citrate transporter
NP436_04210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP436_04215	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NP436_04220	COG1254	Belongs to the acylphosphatase family
NP436_04225	COG2258	MOSC domain
NP436_04245	COG0024	Methionine aminopeptidase
NP436_04250	COG1263	PTS System
NP436_04250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_04255	COG1368	sulfuric ester hydrolase activity
NP436_04270	COG1115	amino acid carrier protein
NP436_04285	COG1263	PTS System
NP436_04285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_04290	COG0366	Alpha amylase catalytic
NP436_04295	COG2188	Transcriptional regulator
NP436_04300	COG0778	Nitroreductase
NP436_04305	COG0737	Belongs to the 5'-nucleotidase family
NP436_04310	COG0693	protein deglycase activity
NP436_04320	COG2814	Major facilitator Superfamily
NP436_04325	COG4840	Belongs to the UPF0435 family
NP436_04330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP436_04335	COG4980	gas vesicle protein
NP436_04340	COG1295	ribonuclease BN
NP436_04350	COG0477	Major facilitator Superfamily
NP436_04355	COG0387	Pfam Sodium calcium exchanger
NP436_04365	COG0668	transmembrane transport
NP436_04370	COG0535	radical SAM domain protein
NP436_04380	COG0726	polysaccharide deacetylase
NP436_04385	COG2084	Dehydrogenase
NP436_04390	COG0598	Magnesium transport protein CorA
NP436_04395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NP436_04400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP436_04410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP436_04415	COG4637	Psort location Cytoplasmic, score
NP436_04425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP436_04430	COG0022	dehydrogenase e1 component
NP436_04435	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP436_04440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP436_04445	COG3284	Transcriptional regulator
NP436_04455	COG1742	UPF0060 membrane protein
NP436_04480	COG4842	Belongs to the WXG100 family
NP436_04485	COG1486	melibiose metabolic process
NP436_04490	COG1737	Transcriptional regulator
NP436_04495	COG1263	PTS System
NP436_04495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_04500	COG5434	Belongs to the glycosyl hydrolase 28 family
NP436_04505	COG1132	(ABC) transporter
NP436_04510	COG1132	(ABC) transporter
NP436_04515	COG2259	Doxx family
NP436_04520	COG2514	catechol 2,3-dioxygenase activity
NP436_04525	COG4977	sequence-specific DNA binding
NP436_04525	COG1917	Cupin 2, conserved barrel domain protein
NP436_04530	COG2814	Major facilitator Superfamily
NP436_04535	COG1082	Xylose isomerase domain protein TIM barrel
NP436_04545	COG4585	Histidine kinase
NP436_04550	COG2197	response regulator
NP436_04555	COG1131	(ABC) transporter
NP436_04560	COG1511	domain protein
NP436_04560	COG0842	Transport permease protein
NP436_04565	COG0842	Transport permease protein
NP436_04570	COG1695	Transcriptional regulator
NP436_04575	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NP436_04580	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
NP436_04585	COG1309	transcriptional regulator
NP436_04590	COG2814	Major facilitator Superfamily
NP436_04595	COG2318	DinB family
NP436_04605	COG1846	Transcriptional regulator
NP436_04610	COG0392	lysyltransferase activity
NP436_04610	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NP436_04615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP436_04620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP436_04625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP436_04630	COG0384	phenazine biosynthesis protein PhzF
NP436_04635	COG0778	Nitroreductase
NP436_04650	COG1090	epimerase
NP436_04655	COG2137	regulation of response to DNA damage stimulus
NP436_04665	COG2814	Major facilitator Superfamily
NP436_04680	COG3103	Sh3 type 3 domain protein
NP436_04685	COG5658	integral membrane protein
NP436_04690	COG0596	Alpha beta hydrolase
NP436_04695	COG0463	Glycosyl transferase, family 2
NP436_04700	COG4485	Bacterial membrane protein, YfhO
NP436_04705	COG1988	membrane-bound metal-dependent
NP436_04710	COG1194	a g-specific adenine glycosylase
NP436_04720	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_04735	COG3557	Belongs to the UPF0374 family
NP436_04740	COG1132	(ABC) transporter
NP436_04745	COG4129	membrane
NP436_04750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP436_04755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NP436_04760	COG0735	belongs to the Fur family
NP436_04875	COG4326	sporulation control protein
NP436_04885	COG5577	PFAM Coat F domain
NP436_04890	COG3340	Belongs to the peptidase S51 family
NP436_04895	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NP436_04910	COG0753	catalase activity
NP436_04915	COG1116	anion transmembrane transporter activity
NP436_04920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP436_04925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP436_04930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP436_04940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NP436_04950	COG1476	TRANSCRIPTIONal
NP436_04960	COG3382	B3 4 domain protein
NP436_04965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NP436_04975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NP436_04980	COG0789	Transcriptional regulator
NP436_04985	COG1664	Polymer-forming cytoskeletal
NP436_04990	COG1664	Polymer-forming cytoskeletal
NP436_04995	COG2766	serine protein kinase
NP436_05000	COG2718	Belongs to the UPF0229 family
NP436_05005	COG1846	Transcriptional regulator
NP436_05010	COG1566	PFAM secretion protein HlyD family protein
NP436_05015	COG2814	Major facilitator Superfamily
NP436_05020	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP436_05040	COG1725	Transcriptional regulator
NP436_05045	COG1131	(ABC) transporter
NP436_05050	COG1131	(ABC) transporter
NP436_05055	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP436_05060	COG1278	Cold shock
NP436_05065	COG1464	Belongs to the NlpA lipoprotein family
NP436_05070	COG3706	GGDEF domain
NP436_05075	COG1823	symporter activity
NP436_05080	COG5444	nuclease activity
NP436_05105	COG0582	viral genome integration into host DNA
NP436_05170	COG5644	endopeptidase inhibitor activity
NP436_05175	COG0741	lytic transglycosylase activity
NP436_05175	COG0791	NLP P60 protein
NP436_05195	COG0457	Tetratricopeptide repeat
NP436_05220	COG0737	Belongs to the 5'-nucleotidase family
NP436_05220	COG1525	nuclease
NP436_05220	COG4085	toxin activity
NP436_05225	COG3764	Sortase (surface protein transpeptidase)
NP436_05230	COG0564	pseudouridine synthase activity
NP436_05240	COG0517	IMP dehydrogenase activity
NP436_05245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP436_05250	COG3153	acetyltransferase
NP436_05250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP436_05255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP436_05260	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NP436_05265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NP436_05275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NP436_05280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NP436_05285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP436_05290	COG4585	Histidine kinase
NP436_05290	COG2203	Gaf domain
NP436_05295	COG2197	response regulator
NP436_05300	COG0431	NADPH-dependent FMN reductase
NP436_05315	COG1388	LysM domain
NP436_05315	COG0791	NLP P60 protein
NP436_05320	COG1959	2 iron, 2 sulfur cluster binding
NP436_05325	COG0668	transmembrane transport
NP436_05330	COG2719	SpoVR family
NP436_05335	COG1785	Belongs to the alkaline phosphatase family
NP436_05340	COG1388	LysM domain
NP436_05340	COG0791	NLP P60 protein
NP436_05345	COG0583	DNA-binding transcription factor activity
NP436_05350	COG0372	Belongs to the citrate synthase family
NP436_05355	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_05360	COG0531	amino acid
NP436_05365	COG0733	neurotransmitter:sodium symporter activity
NP436_05370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP436_05375	COG0456	acetyltransferase
NP436_05390	COG1595	DNA-templated transcription, initiation
NP436_05395	COG0667	Aldo Keto reductase
NP436_05400	COG0204	Acyl-transferase
NP436_05405	COG1253	flavin adenine dinucleotide binding
NP436_05410	COG0789	Transcriptional regulator
NP436_05420	COG1253	flavin adenine dinucleotide binding
NP436_05425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP436_05430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP436_05435	COG0584	glycerophosphoryl diester phosphodiesterase
NP436_05445	COG0668	transmembrane transport
NP436_05450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NP436_05455	COG0726	polysaccharide deacetylase
NP436_05460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP436_05465	COG1757	Na H antiporter
NP436_05470	COG0589	response to stress
NP436_05480	COG1132	(ABC) transporter
NP436_05485	COG1132	(ABC) transporter
NP436_05490	COG0702	epimerase
NP436_05515	COG0189	ligase activity
NP436_05520	COG0189	ligase activity
NP436_05525	COG4399	Belongs to the UPF0754 family
NP436_05530	COG3679	Belongs to the UPF0342 family
NP436_05540	COG0561	phosphatase activity
NP436_05545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP436_05550	COG0475	glutathione-regulated potassium exporter activity
NP436_05555	COG0490	domain, Protein
NP436_05565	COG1024	Enoyl-CoA hydratase
NP436_05575	COG4152	abc transporter atp-binding protein
NP436_05580	COG1668	transmembrane transport
NP436_05585	COG0420	3'-5' exonuclease activity
NP436_05590	COG4717	serine-type aminopeptidase activity
NP436_05595	COG3481	metal-dependent phosphohydrolase, HD sub domain
NP436_05605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP436_05635	COG1846	Transcriptional regulator
NP436_05640	COG4980	gas vesicle protein
NP436_05655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NP436_05660	COG0537	adenosine 5'-monophosphoramidase activity
NP436_05665	COG1131	(ABC) transporter
NP436_05670	COG4473	ABC transporter
NP436_05680	COG1473	amidohydrolase
NP436_05685	COG3069	C4-dicarboxylate transmembrane transporter activity
NP436_05695	COG2329	Antibiotic biosynthesis monooxygenase
NP436_05700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP436_05705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NP436_05710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NP436_05715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NP436_05720	COG1309	transcriptional regulator
NP436_05725	COG1511	domain protein
NP436_05730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP436_05735	COG4377	Putative membrane peptidase family (DUF2324)
NP436_05745	COG1363	Peptidase, m42
NP436_05750	COG4405	Protein conserved in bacteria
NP436_05755	COG1301	dicarboxylic acid transport
NP436_05765	COG1234	tRNA 3'-trailer cleavage
NP436_05770	COG0095	Lipoate-protein ligase
NP436_05775	COG0702	epimerase
NP436_05780	COG0318	PFAM AMP-dependent synthetase and ligase
NP436_05790	COG0501	Belongs to the peptidase M48B family
NP436_05800	COG0456	acetyltransferase
NP436_05805	COG0604	alcohol dehydrogenase
NP436_05810	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP436_05815	COG0406	alpha-ribazole phosphatase activity
NP436_05820	COG0183	Belongs to the thiolase family
NP436_05825	COG0318	PFAM AMP-dependent synthetase and ligase
NP436_05830	COG1268	BioY protein
NP436_05835	COG0840	transmembrane signaling receptor activity
NP436_05845	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_05855	COG4903	ComK protein
NP436_05860	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_05870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP436_05885	COG0398	Pfam SNARE associated Golgi protein
NP436_05890	COG0681	Belongs to the peptidase S26 family
NP436_05895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP436_05900	COG1846	Transcriptional regulator
NP436_05910	COG0738	Major facilitator superfamily
NP436_05915	COG0673	inositol 2-dehydrogenase activity
NP436_05920	COG0561	phosphatase activity
NP436_05925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP436_05930	COG1609	Transcriptional regulator
NP436_05935	COG3180	Ammonia monooxygenase
NP436_05940	COG2814	Major facilitator Superfamily
NP436_05940	COG0477	Major facilitator Superfamily
NP436_05945	COG4533	DNA binding
NP436_05965	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NP436_05970	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NP436_05975	COG1074	ATP-dependent DNA helicase activity
NP436_05980	COG0420	3'-5' exonuclease activity
NP436_05985	COG0419	ATPase involved in DNA repair
NP436_05990	COG1403	HNH endonuclease
NP436_06030	COG5337	Spore coat protein CotH
NP436_06035	COG0179	Fumarylacetoacetate (FAA) hydrolase
NP436_06045	COG1404	Belongs to the peptidase S8 family
NP436_06055	COG0367	asparagine synthase
NP436_06065	COG0534	Mate efflux family protein
NP436_06070	COG1917	Cupin 2, conserved barrel domain protein
NP436_06070	COG2207	Transcriptional regulator
NP436_06075	COG1609	Transcriptional regulator
NP436_06080	COG0673	inositol 2-dehydrogenase activity
NP436_06085	COG2318	DinB family
NP436_06090	COG1279	arginine transmembrane transporter activity
NP436_06095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP436_06100	COG1357	PFAM Pentapeptide repeats (8 copies)
NP436_06105	COG2267	carboxylic ester hydrolase activity
NP436_06115	COG2153	protein acetylation
NP436_06120	COG0646	methionine synthase
NP436_06120	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NP436_06125	COG1666	GTP binding
NP436_06140	COG1307	EDD domain protein, DegV family
NP436_06145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP436_06165	COG0561	phosphatase activity
NP436_06170	COG1073	alpha beta
NP436_06175	COG2151	metal-sulfur cluster biosynthetic enzyme
NP436_06185	COG0277	FAD linked oxidase domain protein
NP436_06195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NP436_06200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NP436_06210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP436_06215	COG0505	Belongs to the CarA family
NP436_06220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP436_06225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NP436_06245	COG2267	carboxylic ester hydrolase activity
NP436_06255	COG1744	ABC transporter substrate-binding protein PnrA-like
NP436_06270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP436_06275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP436_06280	COG5504	Zn-dependent protease
NP436_06285	COG0444	Belongs to the ABC transporter superfamily
NP436_06290	COG4608	Belongs to the ABC transporter superfamily
NP436_06300	COG0601	transmembrane transport
NP436_06305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP436_06315	COG0180	Tryptophanyl-tRNA synthetase
NP436_06320	COG4166	transmembrane transport
NP436_06325	COG0601	transmembrane transport
NP436_06330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP436_06335	COG0444	Belongs to the ABC transporter superfamily
NP436_06340	COG4608	Belongs to the ABC transporter superfamily
NP436_06345	COG2814	Major facilitator Superfamily
NP436_06350	COG0456	acetyltransferase
NP436_06355	COG1393	Belongs to the ArsC family
NP436_06360	COG0861	Integral membrane protein TerC family
NP436_06370	COG4862	establishment of competence for transformation
NP436_06380	COG4469	Competence protein
NP436_06385	COG1164	Oligoendopeptidase f
NP436_06395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP436_06400	COG2346	COG2346, Truncated hemoglobins
NP436_06405	COG0741	lytic transglycosylase activity
NP436_06410	COG4116	CYTH
NP436_06420	COG2357	RelA SpoT domain protein
NP436_06425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP436_06430	COG0564	pseudouridine synthase activity
NP436_06435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NP436_06440	COG0569	domain protein
NP436_06440	COG0475	glutathione-regulated potassium exporter activity
NP436_06445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NP436_06450	COG0352	thiamine-phosphate diphosphorylase activity
NP436_06455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP436_06460	COG2104	thiamine diphosphate biosynthetic process
NP436_06465	COG2022	thiamine diphosphate biosynthetic process
NP436_06470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP436_06475	COG0351	phosphomethylpyrimidine kinase
NP436_06480	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NP436_06535	COG0210	DNA helicase
NP436_06545	COG2153	protein acetylation
NP436_06550	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP436_06555	COG2382	esterase
NP436_06560	COG0626	cystathionine gamma-synthase activity
NP436_06565	COG0626	cystathionine gamma-synthase activity
NP436_06570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP436_06575	COG5505	Protein of unknown function (DUF819)
NP436_06615	COG1396	sequence-specific DNA binding
NP436_06700	COG0457	Tetratricopeptide repeat
NP436_06705	COG5444	nuclease activity
NP436_06720	COG3328	transposase activity
NP436_06730	COG2084	Dehydrogenase
NP436_06735	COG0840	transmembrane signaling receptor activity
NP436_06740	COG0456	acetyltransferase
NP436_06745	COG1533	DNA photolyase activity
NP436_06755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP436_06760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP436_06765	COG2190	(PTS) system
NP436_06765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_06765	COG1263	PTS System
NP436_06770	COG3711	transcriptional antiterminator
NP436_06775	COG1609	Transcriptional regulator
NP436_06780	COG0006	proline dipeptidase activity
NP436_06790	COG2217	Heavy metal translocating P-type atpase
NP436_06795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP436_06800	COG2244	polysaccharide biosynthetic process
NP436_06805	COG3773	Cell wall hydrolase
NP436_06815	COG4873	Protein conserved in bacteria
NP436_06825	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NP436_06830	COG0602	queuosine metabolic process
NP436_06835	COG0720	synthase
NP436_06840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NP436_06845	COG3949	Membrane
NP436_06850	COG0542	response to heat
NP436_06855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP436_06860	COG1360	Flagellar Motor Protein
NP436_06865	COG1846	Transcriptional regulator
NP436_06870	COG3852	Histidine kinase
NP436_06885	COG3339	Conserved Protein
NP436_06890	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NP436_06895	COG0235	Class ii aldolase
NP436_06900	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NP436_06905	COG1850	ribulose-bisphosphate carboxylase activity
NP436_06910	COG0436	Aminotransferase
NP436_06915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP436_06920	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NP436_06925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NP436_06935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP436_06940	COG5002	protein histidine kinase activity
NP436_06945	COG3594	Acyltransferase
NP436_06960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP436_06965	COG0501	Belongs to the peptidase M48B family
NP436_06985	COG1191	sigma factor activity
NP436_06990	COG0861	Integral membrane protein TerC family
NP436_06995	COG0586	Pfam SNARE associated Golgi protein
NP436_07000	COG3300	MHYT domain
NP436_07000	COG5001	Diguanylate cyclase
NP436_07005	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NP436_07010	COG3285	dna ligase
NP436_07010	COG1793	dna ligase
NP436_07015	COG0463	Glycosyl transferase, family 2
NP436_07025	COG1408	metallophosphoesterase
NP436_07030	COG0726	polysaccharide deacetylase
NP436_07035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP436_07040	COG1846	Transcriptional regulator
NP436_07055	COG0789	Transcriptional regulator
NP436_07060	COG2239	Acts as a magnesium transporter
NP436_07075	COG3212	peptidase
NP436_07080	COG3212	peptidase
NP436_07085	COG5002	protein histidine kinase activity
NP436_07085	COG3850	Histidine kinase
NP436_07090	COG0745	RESPONSE REGULATOR receiver
NP436_07100	COG4721	ABC-type cobalt transport system, permease component
NP436_07105	COG1122	ATPase activity
NP436_07110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP436_07115	COG1366	Belongs to the anti-sigma-factor antagonist family
NP436_07120	COG1404	Belongs to the peptidase S8 family
NP436_07125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP436_07135	COG0590	tRNA wobble adenosine to inosine editing
NP436_07145	COG1764	response to oxidative stress
NP436_07150	COG1846	Transcriptional regulator
NP436_07155	COG1764	response to oxidative stress
NP436_07160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NP436_07165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP436_07170	COG0788	formyltetrahydrofolate deformylase activity
NP436_07175	COG2076	Multidrug Resistance protein
NP436_07180	COG2076	Multidrug Resistance protein
NP436_07185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP436_07190	COG2318	DinB family
NP436_07195	COG2323	membrane
NP436_07205	COG1017	nitric oxide dioxygenase activity
NP436_07205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP436_07210	COG1607	acyl-coa hydrolase
NP436_07220	COG2706	6-phosphogluconolactonase activity
NP436_07225	COG4608	Belongs to the ABC transporter superfamily
NP436_07230	COG0791	NLP P60 protein
NP436_07235	COG4948	Mandelate Racemase Muconate Lactonizing
NP436_07240	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP436_07245	COG4166	transmembrane transport
NP436_07250	COG0444	Belongs to the ABC transporter superfamily
NP436_07255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP436_07260	COG0601	transmembrane transport
NP436_07265	COG2362	D-Aminopeptidase
NP436_07270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP436_07275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP436_07280	COG0463	Glycosyl transferase, family 2
NP436_07285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP436_07295	COG0346	lactoylglutathione lyase activity
NP436_07300	COG0531	amino acid
NP436_07305	COG1392	Phosphate transport regulator
NP436_07310	COG0306	phosphate transporter
NP436_07330	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP436_07330	COG3409	Peptidoglycan-binding domain 1 protein
NP436_07370	COG3778	Protein conserved in bacteria
NP436_07375	COG3299	homolog of phage Mu protein gp47
NP436_07380	COG3628	GPW Gp25 family protein
NP436_07390	COG4193	domain, Protein
NP436_07395	COG1652	LysM domain
NP436_07400	COG5412	phage tail tape measure protein
NP436_07400	COG3953	SLT domain
NP436_07400	COG5412	phage tail tape measure protein
NP436_07400	COG3953	SLT domain
NP436_07400	COG3953	SLT domain
NP436_07400	COG5412	phage tail tape measure protein
NP436_07450	COG4653	Phage capsid family
NP436_07455	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NP436_07460	COG5518	Phage portal protein
NP436_07465	COG1783	phage Terminase large subunit
NP436_07470	COG3728	DNA packaging
NP436_07470	COG5484	DNA packaging
NP436_07475	COG1595	DNA-templated transcription, initiation
NP436_07495	COG1484	DNA-dependent DNA replication
NP436_07500	COG1522	sequence-specific DNA binding
NP436_07510	COG1396	sequence-specific DNA binding
NP436_07515	COG2856	Zn peptidase
NP436_07520	COG3546	catalase activity
NP436_07525	COG4195	phage-related replication protein
NP436_07535	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP436_07535	COG3409	Peptidoglycan-binding domain 1 protein
NP436_07535	COG1388	LysM domain
NP436_07550	COG0457	Tetratricopeptide repeat
NP436_07570	COG2318	DinB family
NP436_07575	COG0730	response to heat
NP436_07580	COG2721	sulfolactate sulfo-lyase activity
NP436_07585	COG0246	Mannitol dehydrogenase
NP436_07590	COG1609	Transcriptional regulator
NP436_07595	COG2271	Major facilitator Superfamily
NP436_07600	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_07605	COG1312	Catalyzes the dehydration of D-mannonate
NP436_07610	COG1063	alcohol dehydrogenase
NP436_07615	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NP436_07620	COG2211	Major facilitator Superfamily
NP436_07625	COG1904	glucuronate isomerase
NP436_07630	COG1252	NADH dehydrogenase
NP436_07645	COG0697	spore germination
NP436_07650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP436_07655	COG0390	transport system, permease component
NP436_07660	COG1587	Uroporphyrinogen-III synthase
NP436_07670	COG1819	glycosyl
NP436_07675	COG2124	cytochrome p450
NP436_07685	COG1051	belongs to the nudix hydrolase family
NP436_07695	COG2427	Protein of unknown function (DUF1641)
NP436_07710	COG2205	protein histidine kinase activity
NP436_07715	COG5504	Zn-dependent protease
NP436_07730	COG0726	polysaccharide deacetylase
NP436_07740	COG0109	protoheme IX farnesyltransferase activity
NP436_07755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NP436_07765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP436_07780	COG1482	cell wall glycoprotein biosynthetic process
NP436_07785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP436_07785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP436_07785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP436_07790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP436_07790	COG3711	transcriptional antiterminator
NP436_07800	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NP436_07860	COG3328	transposase activity
NP436_07870	COG0768	penicillin binding
NP436_07875	COG4191	Histidine kinase
NP436_07880	COG0436	Aminotransferase
NP436_07890	COG0835	chemotaxis
NP436_07890	COG0784	Response regulator, receiver
NP436_07900	COG2814	Major facilitator Superfamily
NP436_07905	COG1376	ErfK ybiS ycfS ynhG family protein
NP436_07910	COG1408	metallophosphoesterase
NP436_07915	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_07920	COG2200	EAL domain
NP436_07925	COG4703	Protein of unknown function (DUF1797)
NP436_07930	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NP436_07940	COG0517	IMP dehydrogenase activity
NP436_07945	COG0583	DNA-binding transcription factor activity
NP436_07950	COG0716	FMN binding
NP436_07960	COG0716	FMN binding
NP436_07965	COG2171	N-acyltransferase activity
NP436_07970	COG1473	amidohydrolase
NP436_07980	COG0668	transmembrane transport
NP436_07985	COG0450	alkyl hydroperoxide reductase
NP436_07990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP436_08010	COG0746	molybdenum cofactor guanylyltransferase activity
NP436_08015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP436_08020	COG0303	'Molybdopterin
NP436_08025	COG1763	Mo-molybdopterin cofactor biosynthetic process
NP436_08030	COG0314	molybdopterin synthase activity
NP436_08035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NP436_08045	COG1132	(ABC) transporter
NP436_08055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP436_08060	COG1136	(ABC) transporter
NP436_08065	COG0577	efflux transmembrane transporter activity
NP436_08070	COG1349	DNA-binding transcription factor activity
NP436_08075	COG1105	Belongs to the carbohydrate kinase PfkB family
NP436_08080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP436_08080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP436_08080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP436_08085	COG0681	Belongs to the peptidase S26 family
NP436_08095	COG0488	(ABC) transporter
NP436_08100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP436_08105	COG2309	aminopeptidase activity
NP436_08115	COG1077	Cell shape determining protein MreB Mrl
NP436_08120	COG2002	toxin-antitoxin pair type II binding
NP436_08125	COG3852	Histidine kinase
NP436_08130	COG2105	PFAM AIG2 family protein
NP436_08130	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NP436_08135	COG0569	domain protein
NP436_08140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP436_08145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP436_08150	COG5503	Protein of unknown function (DUF1447)
NP436_08155	COG0561	phosphatase activity
NP436_08160	COG0242	peptide deformylase activity
NP436_08175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP436_08180	COG0022	dehydrogenase e1 component
NP436_08185	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP436_08190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP436_08195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP436_08205	COG1982	Orn Lys Arg decarboxylase major
NP436_08210	COG4476	Belongs to the UPF0223 family
NP436_08215	COG4493	Belongs to the UPF0637 family
NP436_08225	COG0483	inositol monophosphate 1-phosphatase activity
NP436_08240	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NP436_08280	COG1217	gtp-binding protein TYPA
NP436_08290	COG4896	Protein conserved in bacteria
NP436_08300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NP436_08305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP436_08310	COG2066	Belongs to the glutaminase family
NP436_08315	COG4838	Belongs to the UPF0358 family
NP436_08320	COG0772	Belongs to the SEDS family
NP436_08325	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NP436_08330	COG1612	heme a metabolic process
NP436_08335	COG0109	protoheme IX farnesyltransferase activity
NP436_08340	COG2010	Cytochrome c
NP436_08340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP436_08345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP436_08350	COG1845	cytochrome c oxidase, subunit III
NP436_08355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP436_08360	COG3336	cytochrome c oxidase
NP436_08370	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NP436_08375	COG2340	Cysteine-rich secretory protein family
NP436_08390	COG3679	Belongs to the UPF0342 family
NP436_08395	COG4471	UPF0298 protein
NP436_08400	COG0742	ribosomal rna small subunit methyltransferase
NP436_08405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NP436_08410	COG3314	Sporulation integral membrane protein YlbJ
NP436_08415	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP436_08420	COG3480	Lon protease (S16) C-terminal proteolytic domain
NP436_08425	COG1323	Belongs to the UPF0348 family
NP436_08435	COG1399	metal-binding, possibly nucleic acid-binding protein
NP436_08450	COG0454	-acetyltransferase
NP436_08455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP436_08460	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NP436_08465	COG2001	Belongs to the MraZ family
NP436_08470	COG0275	rRNA processing
NP436_08475	COG4839	cell division protein FtsL
NP436_08480	COG0768	penicillin binding
NP436_08485	COG0768	penicillin binding
NP436_08490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NP436_08495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP436_08500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP436_08505	COG0772	Belongs to the SEDS family
NP436_08510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP436_08515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NP436_08520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NP436_08525	COG3879	Bacterial protein of unknown function (DUF881)
NP436_08530	COG3879	Bacterial protein of unknown function (DUF881)
NP436_08535	COG3856	small basic protein
NP436_08540	COG0849	cell division
NP436_08545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NP436_08550	COG4412	M6 family metalloprotease domain protein
NP436_08550	COG1404	Belongs to the peptidase S8 family
NP436_08560	COG1191	sigma factor activity
NP436_08565	COG1191	sigma factor activity
NP436_08570	COG1119	ATPase activity
NP436_08575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP436_08580	COG1873	PFAM PRC-barrel domain
NP436_08585	COG1496	oxidoreductase activity
NP436_08590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NP436_08595	COG1799	cell septum assembly
NP436_08600	COG0762	integral membrane protein
NP436_08605	COG2302	S4 RNA-binding domain
NP436_08610	COG3599	regulation of cell shape
NP436_08615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NP436_08620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP436_08625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NP436_08630	COG0564	pseudouridine synthase activity
NP436_08635	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NP436_08640	COG2233	PERMEase
NP436_08645	COG0540	Belongs to the ATCase OTCase family
NP436_08650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP436_08655	COG0505	Belongs to the CarA family
NP436_08660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP436_08665	COG0543	2 iron, 2 sulfur cluster binding
NP436_08670	COG0167	dihydroorotate dehydrogenase activity
NP436_08675	COG0284	orotidine-5'-phosphate decarboxylase activity
NP436_08680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NP436_08685	COG0175	sulfate reduction
NP436_08690	COG0306	phosphate transporter
NP436_08695	COG2046	Belongs to the sulfate adenylyltransferase family
NP436_08700	COG0529	Catalyzes the synthesis of activated sulfate
NP436_08705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP436_08710	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NP436_08715	COG1648	precorrin-2 dehydrogenase activity
NP436_08725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP436_08730	COG1561	YicC-like family, N-terminal region
NP436_08740	COG0194	GDP metabolic process
NP436_08745	COG1758	RNA polymerase activity
NP436_08750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP436_08755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP436_08760	COG0242	peptide deformylase activity
NP436_08765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NP436_08770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NP436_08770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP436_08775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NP436_08780	COG0631	protein serine/threonine phosphatase activity
NP436_08785	COG0515	serine threonine protein kinase
NP436_08785	COG2815	serine threonine protein kinase
NP436_08790	COG1162	GTPase activity
NP436_08795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NP436_08800	COG1564	THIamine pyrophosphokinase
NP436_08810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NP436_08815	COG1302	Protein conserved in bacteria
NP436_08820	COG1461	Dihydroxyacetone kinase
NP436_08825	COG1760	l-serine dehydratase
NP436_08830	COG1760	l-serine dehydratase
NP436_08835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NP436_08840	COG1349	DNA-binding transcription factor activity
NP436_08840	COG2050	protein possibly involved in aromatic compounds catabolism
NP436_08845	COG0416	fatty acid biosynthetic process
NP436_08850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP436_08855	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_08865	COG0571	ribonuclease III activity
NP436_08870	COG1196	nuclear chromosome segregation
NP436_08875	COG0552	protein localization to endoplasmic reticulum
NP436_08885	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NP436_08890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NP436_08895	COG0228	four-way junction DNA binding
NP436_08900	COG1837	Belongs to the UPF0109 family
NP436_08910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NP436_08915	COG0336	Belongs to the RNA methyltransferase TrmD family
NP436_08920	COG0335	large ribosomal subunit rRNA binding
NP436_08925	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP436_08930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP436_08940	COG2257	FlhB HrpN YscU SpaS Family
NP436_08945	COG0045	succinate-CoA ligase (ADP-forming) activity
NP436_08950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NP436_08955	COG0758	DNA mediated transformation
NP436_08960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP436_08965	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NP436_08970	COG4974	Belongs to the 'phage' integrase family
NP436_08975	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NP436_08980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NP436_08985	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP436_08990	COG1815	bacterial-type flagellum-dependent cell motility
NP436_08995	COG1558	bacterial-type flagellum-dependent cell motility
NP436_09000	COG1677	Flagellar hook-basal body complex protein FliE
NP436_09010	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP436_09015	COG1317	bacterial-type flagellum organization
NP436_09020	COG1157	protein secretion by the type III secretion system
NP436_09025	COG2882	bacterial-type flagellum organization
NP436_09030	COG3334	PFAM MgtE intracellular
NP436_09035	COG3144	bacterial-type flagellum assembly
NP436_09040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NP436_09045	COG4786	Flagellar basal body rod
NP436_09050	COG1582	Flagellar protein (FlbD)
NP436_09055	COG1580	Controls the rotational direction of flagella during chemotaxis
NP436_09060	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP436_09065	COG1776	CheC inhibitor of MCP methylation
NP436_09065	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP436_09070	COG2201	protein-glutamate methylesterase activity
NP436_09075	COG3190	flagellar
NP436_09080	COG1338	Plays a role in the flagellum-specific transport system
NP436_09085	COG1987	bacterial-type flagellum assembly
NP436_09090	COG1684	flagellar biosynthetic protein fliR
NP436_09095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP436_09100	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP436_09105	COG1419	protein localization to endoplasmic reticulum
NP436_09110	COG0455	bacterial-type flagellum organization
NP436_09115	COG2201	protein-glutamate methylesterase activity
NP436_09120	COG0643	Histidine kinase
NP436_09120	COG2198	Histidine kinase
NP436_09125	COG0835	chemotaxis
NP436_09135	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NP436_09140	COG1191	sigma factor activity
NP436_09150	COG0052	Belongs to the universal ribosomal protein uS2 family
NP436_09155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NP436_09160	COG0528	UMP kinase activity
NP436_09165	COG0233	cytoplasmic translational termination
NP436_09170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NP436_09175	COG4589	Belongs to the CDS family
NP436_09180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NP436_09185	COG0750	zinc metalloprotease
NP436_09190	COG0442	prolyl-tRNA aminoacylation
NP436_09195	COG2176	DNA-directed DNA polymerase activity
NP436_09200	COG0779	Required for maturation of 30S ribosomal subunits
NP436_09205	COG0195	Participates in both transcription termination and antitermination
NP436_09210	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NP436_09215	COG1358	cellular component organization or biogenesis
NP436_09220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NP436_09225	COG1550	Protein conserved in bacteria
NP436_09230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NP436_09235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NP436_09240	COG0196	riboflavin kinase activity
NP436_09245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NP436_09250	COG1185	polyribonucleotide nucleotidyltransferase activity
NP436_09255	COG0726	polysaccharide deacetylase
NP436_09260	COG0612	Peptidase, M16
NP436_09265	COG1873	PFAM PRC-barrel domain
NP436_09270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP436_09275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP436_09280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NP436_09285	COG0527	aspartate kinase activity
NP436_09290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP436_09295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP436_09300	COG0740	serine-type endopeptidase activity
NP436_09310	COG1674	ftsk spoiiie
NP436_09310	COG4980	gas vesicle protein
NP436_09315	COG2188	Transcriptional regulator
NP436_09320	COG2814	Major facilitator Superfamily
NP436_09325	COG0612	Peptidase, M16
NP436_09330	COG0612	Peptidase, M16
NP436_09335	COG0300	oxidoreductase activity
NP436_09350	COG1426	Protein conserved in bacteria
NP436_09355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NP436_09360	COG1058	Belongs to the CinA family
NP436_09360	COG1546	Belongs to the CinA family
NP436_09365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NP436_09370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP436_09375	COG1418	mRNA catabolic process
NP436_09380	COG1692	metallophosphoesterase
NP436_09385	COG2359	stage V sporulation protein S
NP436_09390	COG1063	alcohol dehydrogenase
NP436_09395	COG0156	8-amino-7-oxononanoate synthase activity
NP436_09400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP436_09405	COG4550	Control of competence regulator ComK, YlbF/YmcA
NP436_09415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NP436_09420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NP436_09530	COG3226	Transcriptional regulator
NP436_09540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP436_09545	COG1404	Belongs to the peptidase S8 family
NP436_09555	COG4195	phage-related replication protein
NP436_09560	COG1764	response to oxidative stress
NP436_09565	COG2076	Multidrug Resistance protein
NP436_09570	COG2076	Multidrug Resistance protein
NP436_09585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NP436_09590	COG1923	regulation of RNA biosynthetic process
NP436_09605	COG1780	Probably involved in ribonucleotide reductase function
NP436_09610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP436_09615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP436_09620	COG4112	unkown
NP436_09625	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP436_09630	COG0464	growth
NP436_09635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NP436_09640	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NP436_09645	COG0789	Transcriptional regulator
NP436_09650	COG0174	glutamine synthetase
NP436_09655	COG4974	Belongs to the 'phage' integrase family
NP436_09675	COG3646	Phage regulatory protein
NP436_09675	COG3645	SOS response
NP436_09825	COG3953	SLT domain
NP436_09825	COG5412	phage tail tape measure protein
NP436_09870	COG3409	Peptidoglycan-binding domain 1 protein
NP436_09870	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP436_09870	COG1388	LysM domain
NP436_09880	COG5444	nuclease activity
NP436_09915	COG4282	regulation of fungal-type cell wall biogenesis
NP436_09940	COG1525	nuclease
NP436_09945	COG2814	Major facilitator Superfamily
NP436_09950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP436_09965	COG0756	dUTP diphosphatase activity
NP436_10005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP436_10025	COG3832	glyoxalase III activity
NP436_10065	COG4195	phage-related replication protein
NP436_10075	COG0346	lactoylglutathione lyase activity
NP436_10085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NP436_10090	COG1388	LysM domain
NP436_10095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP436_10100	COG4224	UPF0291 protein
NP436_10105	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NP436_10115	COG3763	UPF0154 protein
NP436_10125	COG0785	Cytochrome C biogenesis protein
NP436_10130	COG2201	protein-glutamate methylesterase activity
NP436_10135	COG4846	Membrane protein involved in cytochrome C biogenesis
NP436_10145	COG0071	Belongs to the small heat shock protein (HSP20) family
NP436_10160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NP436_10165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP436_10185	COG0824	Thioesterase
NP436_10200	COG4841	protein insertion into membrane
NP436_10205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NP436_10210	COG1832	CoA-binding protein
NP436_10215	COG0187	DNA topoisomerase II activity
NP436_10220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP436_10235	COG1115	amino acid carrier protein
NP436_10240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NP436_10250	COG5520	Belongs to the glycosyl hydrolase 30 family
NP436_10260	COG2246	polysaccharide biosynthetic process
NP436_10265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP436_10270	COG0586	Pfam SNARE associated Golgi protein
NP436_10275	COG2404	hydrolase activity, acting on ester bonds
NP436_10280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP436_10285	COG1024	Enoyl-CoA hydratase
NP436_10290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP436_10295	COG0511	ligase activity, forming carbon-carbon bonds
NP436_10300	COG0439	Biotin carboxylase
NP436_10305	COG0318	PFAM AMP-dependent synthetase and ligase
NP436_10310	COG1960	acyl-CoA dehydrogenase activity
NP436_10325	COG1649	PFAM Uncharacterised BCR, COG1649
NP436_10340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP436_10345	COG2027	D-alanyl-D-alanine carboxypeptidase
NP436_10350	COG2017	converts alpha-aldose to the beta-anomer
NP436_10355	COG0534	Mate efflux family protein
NP436_10375	COG0582	viral genome integration into host DNA
NP436_10380	COG0166	Belongs to the GPI family
NP436_10385	COG0405	Gamma-glutamyltransferase
NP436_10390	COG0583	DNA-binding transcription factor activity
NP436_10395	COG0604	alcohol dehydrogenase
NP436_10400	COG0493	'glutamate synthase
NP436_10405	COG0067	glutamate synthase
NP436_10405	COG0070	glutamate synthase
NP436_10405	COG0069	glutamate synthase activity
NP436_10410	COG0583	DNA-binding transcription factor activity
NP436_10440	COG0300	oxidoreductase activity
NP436_10445	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NP436_10455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP436_10470	COG1131	(ABC) transporter
NP436_10480	COG2814	Major facilitator Superfamily
NP436_10535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP436_10540	COG2226	methyltransferase
NP436_10545	COG2211	Major facilitator Superfamily
NP436_10550	COG3328	transposase activity
NP436_10580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP436_10600	COG5444	nuclease activity
NP436_10605	COG4282	regulation of fungal-type cell wall biogenesis
NP436_10610	COG1231	oxidoreductase activity
NP436_10615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP436_10620	COG0662	Cupin 2, conserved barrel domain protein
NP436_10620	COG2207	Transcriptional regulator
NP436_10625	COG0456	acetyltransferase
NP436_10630	COG1309	transcriptional regulator
NP436_10635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP436_10640	COG3708	Transcriptional regulator
NP436_10645	COG2378	regulation of single-species biofilm formation
NP436_10655	COG0640	Transcriptional regulator
NP436_10660	COG0741	lytic transglycosylase activity
NP436_10665	COG2322	membrane
NP436_10680	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP436_10685	COG3239	Fatty acid desaturase
NP436_10690	COG4585	Histidine kinase
NP436_10695	COG2197	response regulator
NP436_10700	COG3584	3D domain protein
NP436_10700	COG1388	LysM domain
NP436_10705	COG0514	ATP-dependent DNA helicase (RecQ)
NP436_10715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP436_10720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP436_10735	COG0071	Belongs to the small heat shock protein (HSP20) family
NP436_10760	COG1012	belongs to the aldehyde dehydrogenase family
NP436_10765	COG1657	PFAM Prenyltransferase squalene oxidase
NP436_10770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP436_10775	COG0733	neurotransmitter:sodium symporter activity
NP436_10780	COG0385	Bile acid
NP436_10785	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP436_10790	COG0567	Dehydrogenase, E1 component
NP436_10795	COG4548	von Willebrand factor, type A
NP436_10800	COG0714	Associated with various cellular activities
NP436_10805	COG2032	superoxide dismutase activity
NP436_10810	COG0791	NLP P60 protein
NP436_10810	COG1388	LysM domain
NP436_10815	COG1819	glycosyl
NP436_10820	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP436_10825	COG0534	Mate efflux family protein
NP436_10830	COG1366	Belongs to the anti-sigma-factor antagonist family
NP436_10835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP436_10840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP436_10850	COG2962	Rard protein
NP436_10865	COG2610	gluconate transmembrane transporter activity
NP436_10870	COG2610	gluconate transmembrane transporter activity
NP436_10875	COG1942	4-Oxalocrotonate Tautomerase
NP436_10880	COG1733	regulation of RNA biosynthetic process
NP436_10885	COG0778	Nitroreductase
NP436_10895	COG0400	carboxylic ester hydrolase activity
NP436_10910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP436_10915	COG3409	Peptidoglycan-binding domain 1 protein
NP436_10915	COG0793	Belongs to the peptidase S41A family
NP436_10920	COG2226	methyltransferase
NP436_10930	COG1876	peptidase activity
NP436_10935	COG0813	purine-nucleoside phosphorylase activity
NP436_10950	COG0671	phosphoesterase, PA-phosphatase related
NP436_10970	COG4479	Belongs to the UPF0346 family
NP436_10980	COG1509	lysine 2,3-aminomutase activity
NP436_10985	COG0456	acetyltransferase
NP436_10990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP436_10995	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP436_11000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP436_11005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP436_11020	COG0456	acetyltransferase
NP436_11025	COG0463	Glycosyl transferase, family 2
NP436_11040	COG4641	Protein conserved in bacteria
NP436_11045	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
NP436_11050	COG1086	Polysaccharide biosynthesis protein
NP436_11055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP436_11060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP436_11065	COG1846	Transcriptional regulator
NP436_11070	COG0534	Mate efflux family protein
NP436_11080	COG4698	Protein conserved in bacteria
NP436_11085	COG2755	lipolytic protein G-D-S-L family
NP436_11090	COG1999	signal sequence binding
NP436_11100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NP436_11105	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP436_11110	COG1272	protein, Hemolysin III
NP436_11115	COG0204	Acyl-transferase
NP436_11120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP436_11125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP436_11135	COG2136	Putative SAM-dependent methyltransferase
NP436_11135	COG2521	methyltransferase
NP436_11145	COG0129	dihydroxy-acid dehydratase activity
NP436_11150	COG1413	lyase activity
NP436_11155	COG1418	mRNA catabolic process
NP436_11160	COG0386	Belongs to the glutathione peroxidase family
NP436_11165	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NP436_11170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP436_11180	COG1278	Cold shock
NP436_11200	COG0328	RNA-DNA hybrid ribonuclease activity
NP436_11205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NP436_11210	COG0328	RNA-DNA hybrid ribonuclease activity
NP436_11220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP436_11235	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP436_11245	COG1755	Isoprenylcysteine carboxyl methyltransferase
NP436_11250	COG3424	synthase
NP436_11255	COG2233	PERMEase
NP436_11260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP436_11265	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NP436_11275	COG0800	Aldolase
NP436_11280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP436_11285	COG1609	Transcriptional regulator
NP436_11290	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NP436_11295	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_11300	COG1199	ATP-dependent helicase activity
NP436_11315	COG0116	Belongs to the methyltransferase superfamily
NP436_11330	COG4474	Belongs to the UPF0398 family
NP436_11345	COG3359	exonuclease
NP436_11350	COG1205	dead DEAH box helicase
NP436_11350	COG1111	helicase
NP436_11355	COG2190	(PTS) system
NP436_11360	COG0071	Belongs to the small heat shock protein (HSP20) family
NP436_11395	COG3331	DNA recombination
NP436_11400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP436_11400	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP436_11410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NP436_11415	COG3935	DnaD domain protein
NP436_11420	COG0017	Asparaginyl-tRNA synthetase
NP436_11425	COG0436	Aminotransferase
NP436_11430	COG5353	protein conserved in bacteria
NP436_11440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NP436_11440	COG1199	ATP-dependent helicase activity
NP436_11445	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NP436_11450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NP436_11455	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NP436_11460	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NP436_11460	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NP436_11465	COG0617	tRNA 3'-terminal CCA addition
NP436_11470	COG0438	transferase activity, transferring glycosyl groups
NP436_11475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP436_11480	COG1803	Methylglyoxal synthase
NP436_11485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NP436_11490	COG1694	Mazg nucleotide pyrophosphohydrolase
NP436_11495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP436_11505	COG4347	Protein of unknown function (DUF1405)
NP436_11510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP436_11510	COG2010	Cytochrome c
NP436_11515	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP436_11520	COG0723	plastoquinol--plastocyanin reductase activity
NP436_11530	COG5582	Belongs to the UPF0302 family
NP436_11535	COG0457	Tetratricopeptide repeat
NP436_11540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NP436_11545	COG0287	Prephenate dehydrogenase
NP436_11560	COG0133	tryptophan synthase activity
NP436_11565	COG0135	phosphoribosylanthranilate isomerase activity
NP436_11575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NP436_11580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP436_11585	COG4401	Chorismate mutase type I
NP436_11590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NP436_11595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NP436_11600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NP436_11605	COG0105	UTP biosynthetic process
NP436_11610	COG0142	geranyltranstransferase activity
NP436_11615	COG2226	methyltransferase
NP436_11620	COG0142	geranyltranstransferase activity
NP436_11630	COG0302	gtp cyclohydrolase
NP436_11635	COG0776	regulation of translation
NP436_11640	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP436_11655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NP436_11660	COG1160	GTP binding
NP436_11685	COG1304	FMN binding
NP436_11690	COG0539	negative regulation of cytoplasmic translation
NP436_11695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NP436_11705	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NP436_11710	COG2959	enzyme of heme biosynthesis
NP436_11715	COG3773	Cell wall hydrolase
NP436_11715	COG3409	Peptidoglycan-binding domain 1 protein
NP436_11720	COG2339	peptidase activity
NP436_11725	COG0492	ferredoxin-NADP+ reductase activity
NP436_11730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP436_11735	COG4862	establishment of competence for transformation
NP436_11740	COG1408	metallophosphoesterase
NP436_11750	COG1388	LysM domain
NP436_11755	COG1266	CAAX protease self-immunity
NP436_11760	COG0514	ATP-dependent DNA helicase (RecQ)
NP436_11765	COG4955	Helix-turn-helix domain
NP436_11770	COG1141	Ferredoxin
NP436_11775	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NP436_11780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP436_11785	COG0710	3-dehydroquinate dehydratase activity
NP436_11795	COG1595	DNA-templated transcription, initiation
NP436_11800	COG5002	protein histidine kinase activity
NP436_11805	COG0745	RESPONSE REGULATOR receiver
NP436_11810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP436_11815	COG1333	cytochrome c biogenesis protein
NP436_11820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP436_11825	COG1187	pseudouridine synthase activity
NP436_11830	COG0700	Nucleoside recognition
NP436_11835	COG2715	membrane protein required for spore maturation
NP436_11840	COG1686	Belongs to the peptidase S11 family
NP436_11850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NP436_11855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NP436_11860	COG1547	Domain of unknown function (DUF309)
NP436_11865	COG0456	acetyltransferase
NP436_11870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NP436_11875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP436_11875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP436_11880	COG0307	riboflavin synthase, alpha
NP436_11885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP436_11885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP436_11895	COG0681	Belongs to the peptidase S26 family
NP436_11905	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
NP436_11950	COG3328	transposase activity
NP436_12000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP436_12010	COG4086	secreted protein
NP436_12015	COG0019	diaminopimelate decarboxylase activity
NP436_12020	COG0697	spore germination
NP436_12035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP436_12055	COG1191	sigma factor activity
NP436_12060	COG2172	sigma factor antagonist activity
NP436_12065	COG1366	Belongs to the anti-sigma-factor antagonist family
NP436_12070	COG1686	Belongs to the peptidase S11 family
NP436_12075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NP436_12080	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NP436_12085	COG4974	Belongs to the 'phage' integrase family
NP436_12095	COG0735	belongs to the Fur family
NP436_12100	COG1300	Membrane
NP436_12110	COG0281	malic enzyme
NP436_12115	COG1757	Na H antiporter
NP436_12120	COG1027	Aspartate ammonia-lyase
NP436_12125	COG0252	asparaginase activity
NP436_12130	COG1396	sequence-specific DNA binding
NP436_12135	COG1379	DNA repair
NP436_12140	COG0494	nUDIX hydrolase
NP436_12150	COG0667	Aldo Keto reductase
NP436_12160	COG1073	alpha beta
NP436_12170	COG4918	Iron-sulphur cluster biosynthesis
NP436_12175	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NP436_12175	COG0456	acetyltransferase
NP436_12180	COG2329	Antibiotic biosynthesis monooxygenase
NP436_12185	COG0456	acetyltransferase
NP436_12195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP436_12205	COG2211	Major facilitator Superfamily
NP436_12215	COG0346	lactoylglutathione lyase activity
NP436_12220	COG1072	(Pantothenic acid kinase))
NP436_12225	COG3048	D-serine ammonia-lyase activity
NP436_12230	COG0300	oxidoreductase activity
NP436_12235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP436_12240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP436_12245	COG4187	Peptidase family M20/M25/M40
NP436_12250	COG1902	pentaerythritol trinitrate reductase activity
NP436_12265	COG0596	Alpha beta hydrolase
NP436_12275	COG1234	tRNA 3'-trailer cleavage
NP436_12280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NP436_12285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP436_12290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP436_12300	COG0706	membrane insertase activity
NP436_12305	COG3361	conserved protein (COG2071)
NP436_12310	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP436_12320	COG0346	lactoylglutathione lyase activity
NP436_12330	COG1376	ErfK ybiS ycfS ynhG family protein
NP436_12335	COG4129	membrane
NP436_12340	COG1126	abc transporter atp-binding protein
NP436_12345	COG0765	amino acid transport
NP436_12350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP436_12360	COG1597	lipid kinase activity
NP436_12370	COG4978	Transcriptional regulator
NP436_12370	COG0789	Transcriptional regulator
NP436_12375	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP436_12380	COG0022	dehydrogenase e1 component
NP436_12385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP436_12390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP436_12395	COG3426	butyrate kinase activity
NP436_12400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP436_12405	COG0280	phosphate acetyltransferase
NP436_12410	COG3829	transcription factor binding
NP436_12410	COG3290	protein histidine kinase activity
NP436_12420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NP436_12425	COG2079	MmgE PrpD family protein
NP436_12430	COG0372	Belongs to the citrate synthase family
NP436_12435	COG1960	acyl-CoA dehydrogenase activity
NP436_12440	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP436_12445	COG0183	Belongs to the thiolase family
NP436_12450	COG0584	glycerophosphoryl diester phosphodiesterase
NP436_12455	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP436_12470	COG1902	pentaerythritol trinitrate reductase activity
NP436_12475	COG0745	RESPONSE REGULATOR receiver
NP436_12480	COG0750	zinc metalloprotease
NP436_12485	COG0497	DNA recombination
NP436_12490	COG1438	arginine binding
NP436_12495	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NP436_12500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NP436_12505	COG0142	geranyltranstransferase activity
NP436_12510	COG1722	exodeoxyribonuclease VII activity
NP436_12515	COG1570	exodeoxyribonuclease VII activity
NP436_12520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NP436_12525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP436_12530	COG1302	Protein conserved in bacteria
NP436_12535	COG0439	Biotin carboxylase
NP436_12540	COG0511	ligase activity, forming carbon-carbon bonds
NP436_12585	COG3854	ATPases associated with a variety of cellular activities
NP436_12595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NP436_12600	COG0006	proline dipeptidase activity
NP436_12605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NP436_12615	COG3872	metal-dependent enzyme
NP436_12625	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP436_12630	COG1321	iron dependent repressor
NP436_12635	COG0095	Lipoate-protein ligase
NP436_12640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP436_12645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP436_12650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP436_12655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NP436_12660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP436_12675	COG1396	sequence-specific DNA binding
NP436_12685	COG0681	Belongs to the peptidase S26 family
NP436_12710	COG4940	Competence protein ComGF
NP436_12720	COG4970	Tfp pilus assembly protein FimT
NP436_12725	COG4537	Required for transformation and DNA binding
NP436_12730	COG1459	type II secretion system
NP436_12735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP436_12740	COG0517	IMP dehydrogenase activity
NP436_12745	COG0598	Magnesium transport protein CorA
NP436_12750	COG1253	flavin adenine dinucleotide binding
NP436_12755	COG1366	Belongs to the anti-sigma-factor antagonist family
NP436_12765	COG1393	Belongs to the ArsC family
NP436_12775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP436_12785	COG0011	TIGRFAM Protein of
NP436_12795	COG2866	Carboxypeptidase
NP436_12800	COG1368	sulfuric ester hydrolase activity
NP436_12805	COG1940	carbohydrate kinase activity
NP436_12810	COG4483	Protein conserved in bacteria
NP436_12815	COG0457	Tetratricopeptide repeat
NP436_12815	COG0705	Rhomboid family
NP436_12825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NP436_12835	COG0438	transferase activity, transferring glycosyl groups
NP436_12850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP436_12855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP436_12860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP436_12865	COG0581	inorganic phosphate transmembrane transporter activity
NP436_12870	COG0573	inorganic phosphate transmembrane transporter activity
NP436_12875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NP436_12880	COG0768	penicillin binding
NP436_12885	COG0477	Major facilitator Superfamily
NP436_12890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP436_12895	COG2839	Protein conserved in bacteria
NP436_12900	COG5521	maltodextrose utilization protein MalA
NP436_12905	COG1388	LysM domain
NP436_12910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NP436_12915	COG4709	membrane
NP436_12920	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NP436_12925	COG0735	belongs to the Fur family
NP436_12930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP436_12940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NP436_12945	COG0513	Belongs to the DEAD box helicase family
NP436_12955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NP436_12960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NP436_12965	COG2384	SAM-dependent methyltransferase
NP436_12970	COG2010	Cytochrome c
NP436_12975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NP436_12980	COG0358	DNA primase activity
NP436_12985	COG1671	Belongs to the UPF0178 family
NP436_12990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NP436_12995	COG0517	IMP dehydrogenase activity
NP436_13000	COG0751	glycine-tRNA ligase activity
NP436_13005	COG0752	glycyl-tRNA synthetase alpha subunit
NP436_13010	COG1381	Involved in DNA repair and RecF pathway recombination
NP436_13020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NP436_13025	COG0295	cytidine deaminase activity
NP436_13030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NP436_13035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NP436_13040	COG1480	7TM receptor with intracellular HD hydrolase
NP436_13045	COG1702	phosphate starvation-inducible protein PhoH
NP436_13050	COG0561	phosphatase activity
NP436_13065	COG4864	UPF0365 protein
NP436_13070	COG1030	water channel activity
NP436_13075	COG1610	YqeY-like protein
NP436_13085	COG1283	sodium-dependent phosphate transmembrane transporter activity
NP436_13090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP436_13095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NP436_13100	COG2264	protein methyltransferase activity
NP436_13105	COG0484	heat shock protein binding
NP436_13110	COG0443	Heat shock 70 kDa protein
NP436_13115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NP436_13120	COG1420	regulation of RNA biosynthetic process
NP436_13125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP436_13130	COG0481	GTPase activity
NP436_13140	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP436_13145	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NP436_13150	COG0268	Binds directly to 16S ribosomal RNA
NP436_13155	COG1466	dna polymerase III delta subunit
NP436_13170	COG2333	competence protein COMEC
NP436_13170	COG0658	competence protein
NP436_13175	COG2131	deaminase
NP436_13180	COG1555	photosystem II stabilization
NP436_13180	COG1596	polysaccharide export
NP436_13185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP436_13190	COG2226	methyltransferase
NP436_13195	COG0799	negative regulation of ribosome biogenesis
NP436_13200	COG1713	HD superfamily hydrolase involved in NAD metabolism
NP436_13205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NP436_13210	COG1534	Rna-binding protein
NP436_13215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP436_13220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP436_13225	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NP436_13235	COG2755	lipolytic protein G-D-S-L family
NP436_13240	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP436_13240	COG3409	Peptidoglycan-binding domain 1 protein
NP436_13245	COG0398	Pfam SNARE associated Golgi protein
NP436_13250	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NP436_13260	COG3209	COG3209 Rhs family protein
NP436_13280	COG0114	fumarate hydratase activity
NP436_13285	COG0583	DNA-binding transcription factor activity
NP436_13300	COG0457	Tetratricopeptide repeat
NP436_13340	COG3328	transposase activity
NP436_13445	COG0789	Transcriptional regulator
NP436_13445	COG4978	Transcriptional regulator
NP436_13450	COG2814	Major facilitator Superfamily
NP436_13455	COG0456	acetyltransferase
NP436_13460	COG1253	flavin adenine dinucleotide binding
NP436_13470	COG0697	spore germination
NP436_13475	COG0583	DNA-binding transcription factor activity
NP436_13480	COG2072	flavoprotein involved in K transport
NP436_13485	COG1230	cation diffusion facilitator family transporter
NP436_13500	COG1114	Component of the transport system for branched-chain amino acids
NP436_13505	COG1687	branched-chain amino acid
NP436_13515	COG1522	sequence-specific DNA binding
NP436_13520	COG2732	(Barnase) inhibitor
NP436_13525	COG2124	cytochrome p450
NP436_13535	COG1335	isochorismatase
NP436_13555	COG2318	DinB family
NP436_13565	COG2070	2-Nitropropane dioxygenase
NP436_13570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP436_13590	COG3443	Belongs to the bacterial solute-binding protein 9 family
NP436_13595	COG1595	DNA-templated transcription, initiation
NP436_13600	COG0667	Aldo Keto reductase
NP436_13605	COG3409	Peptidoglycan-binding domain 1 protein
NP436_13610	COG5566	PFAM Mor transcription activator
NP436_13615	COG0596	Alpha beta hydrolase
NP436_13620	COG4991	sh3 domain protein
NP436_13625	COG4991	sh3 domain protein
NP436_13635	COG0346	lactoylglutathione lyase activity
NP436_13645	COG5577	PFAM Coat F domain
NP436_13650	COG1063	alcohol dehydrogenase
NP436_13660	COG5577	PFAM Coat F domain
NP436_13665	COG0789	Transcriptional regulator
NP436_13675	COG1064	alcohol dehydrogenase
NP436_13680	COG0693	protein deglycase activity
NP436_13685	COG1621	beta-fructofuranosidase activity
NP436_13690	COG3716	PTS system mannose fructose sorbose family IID component
NP436_13695	COG3715	PTS system
NP436_13700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_13705	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP436_13710	COG3933	PFAM sigma-54 factor interaction domain-containing protein
NP436_13710	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP436_13720	COG1113	amino acid transport
NP436_13725	COG1280	lysine exporter protein (LysE YggA)
NP436_13730	COG1378	Sugar-specific transcriptional regulator TrmB
NP436_13735	COG1595	DNA-templated transcription, initiation
NP436_13760	COG1309	transcriptional regulator
NP436_13765	COG2226	methyltransferase
NP436_13780	COG2116	formate transmembrane transporter activity
NP436_13785	COG5609	conserved protein (DUF2294)
NP436_13790	COG3383	formate dehydrogenase (NAD+) activity
NP436_13795	COG2427	Protein of unknown function (DUF1641)
NP436_13810	COG0626	cystathionine gamma-synthase activity
NP436_13815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP436_13820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NP436_13825	COG2226	methyltransferase
NP436_13840	COG0768	penicillin binding
NP436_13845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP436_13850	COG0572	uridine kinase
NP436_13855	COG0826	peptidase U32
NP436_13860	COG0826	peptidase U32
NP436_13865	COG4122	O-methyltransferase activity
NP436_13870	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP436_13875	COG3906	Belongs to the UPF0473 family
NP436_13880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NP436_13885	COG4472	Bacterial protein of unknown function (DUF965)
NP436_13890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NP436_13895	COG0628	permease
NP436_13900	COG1126	abc transporter atp-binding protein
NP436_13905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP436_13910	COG0765	amino acid transport
NP436_13915	COG0765	amino acid transport
NP436_13930	COG3881	PFAM PRC-barrel domain
NP436_13935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NP436_13940	COG0457	Tetratricopeptide repeat
NP436_13945	COG0482	sulfurtransferase activity
NP436_13950	COG1104	cysteine desulfurase activity
NP436_13955	COG1959	2 iron, 2 sulfur cluster binding
NP436_13960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NP436_13965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NP436_13975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NP436_13980	COG0124	histidyl-tRNA synthetase
NP436_13990	COG3103	Sh3 type 3 domain protein
NP436_13990	COG4991	sh3 domain protein
NP436_13990	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP436_13995	COG1490	D-aminoacyl-tRNA deacylase activity
NP436_14000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP436_14005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP436_14010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NP436_14010	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NP436_14015	COG5416	Lipopolysaccharide assembly protein A domain
NP436_14020	COG0490	domain, Protein
NP436_14025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP436_14025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP436_14035	COG2244	polysaccharide biosynthetic process
NP436_14040	COG2323	membrane
NP436_14050	COG1862	Preprotein translocase
NP436_14055	COG0343	queuine tRNA-ribosyltransferase activity
NP436_14060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NP436_14070	COG2255	four-way junction helicase activity
NP436_14075	COG0632	four-way junction helicase activity
NP436_14085	COG2814	Major facilitator Superfamily
NP436_14090	COG0673	inositol 2-dehydrogenase activity
NP436_14095	COG2112	serine threonine protein kinase
NP436_14120	COG1115	amino acid carrier protein
NP436_14125	COG0217	transcriptional regulatory protein
NP436_14135	COG1388	LysM domain
NP436_14140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NP436_14145	COG0157	Belongs to the NadC ModD family
NP436_14150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NP436_14155	COG1104	cysteine desulfurase activity
NP436_14160	COG1827	regulation of RNA biosynthetic process
NP436_14165	COG0077	Prephenate dehydratase
NP436_14170	COG4492	Belongs to the UPF0735 family
NP436_14175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NP436_14180	COG3290	protein histidine kinase activity
NP436_14190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NP436_14195	COG2868	ribosomal protein
NP436_14200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NP436_14205	COG1994	Peptidase M50
NP436_14210	COG0739	heme binding
NP436_14215	COG2894	cell division
NP436_14220	COG0850	regulation of cytokinetic process
NP436_14225	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NP436_14235	COG1077	Cell shape determining protein MreB Mrl
NP436_14240	COG2003	Belongs to the UPF0758 family
NP436_14245	COG0424	maF-like protein
NP436_14255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NP436_14260	COG0285	dihydrofolate synthase activity
NP436_14265	COG0525	valine-tRNA ligase activity
NP436_14275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP436_14280	COG1388	LysM domain
NP436_14285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP436_14290	COG0113	porphobilinogen synthase activity
NP436_14295	COG1587	Uroporphyrinogen-III synthase
NP436_14300	COG0181	hydroxymethylbilane synthase activity
NP436_14305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP436_14310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NP436_14320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NP436_14325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NP436_14330	COG0470	DNA polymerase III
NP436_14330	COG1067	ATP-dependent peptidase activity
NP436_14335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NP436_14340	COG0544	peptidyl-prolyl cis-trans isomerase activity
NP436_14345	COG1477	protein flavinylation
NP436_14345	COG0457	Tetratricopeptide repeat
NP436_14350	COG0066	3-isopropylmalate dehydratase activity
NP436_14355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NP436_14360	COG0473	3-isopropylmalate dehydrogenase activity
NP436_14365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP436_14370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NP436_14375	COG0440	acetolactate synthase activity
NP436_14380	COG0028	Belongs to the TPP enzyme family
NP436_14395	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NP436_14420	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NP436_14450	COG0622	Phosphoesterase
NP436_14455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NP436_14460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NP436_14465	COG5401	PFAM Sporulation and spore germination
NP436_14470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP436_14475	COG1846	Transcriptional regulator
NP436_14480	COG2197	response regulator
NP436_14485	COG0824	Thioesterase
NP436_14490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NP436_14495	COG1053	succinate dehydrogenase
NP436_14500	COG2009	succinate dehydrogenase
NP436_14505	COG1719	4-vinyl reductase, 4VR
NP436_14510	COG0527	aspartate kinase activity
NP436_14515	COG0322	excinuclease ABC activity
NP436_14520	COG3118	belongs to the thioredoxin family
NP436_14525	COG3534	alpha-L-arabinofuranosidase
NP436_14530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NP436_14535	COG2086	electron transfer activity
NP436_14540	COG1024	Enoyl-CoA hydratase
NP436_14545	COG1309	transcriptional regulator
NP436_14550	COG0318	PFAM AMP-dependent synthetase and ligase
NP436_14555	COG3766	membrane
NP436_14560	COG1193	negative regulation of DNA recombination
NP436_14565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP436_14565	COG1796	DNA polymerase
NP436_14570	COG1286	toxin biosynthetic process
NP436_14575	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NP436_14580	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP436_14585	COG0072	phenylalanine-tRNA ligase activity
NP436_14585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP436_14590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NP436_14600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP436_14610	COG3835	regulator
NP436_14615	COG0277	FAD linked oxidase domain protein
NP436_14620	COG0247	lactate metabolic process
NP436_14625	COG0346	lactoylglutathione lyase activity
NP436_14635	COG1966	Carbon starvation protein
NP436_14640	COG3534	alpha-L-arabinofuranosidase
NP436_14645	COG0395	ABC-type sugar transport system, permease component
NP436_14650	COG1175	transmembrane transport
NP436_14655	COG1653	transport
NP436_14660	COG0371	Dehydrogenase
NP436_14665	COG0647	UMP catabolic process
NP436_14670	COG0235	Class ii aldolase
NP436_14675	COG1069	ribulokinase activity
NP436_14680	COG2160	L-arabinose isomerase activity
NP436_14690	COG1363	Peptidase, m42
NP436_14700	COG3326	Membrane
NP436_14705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NP436_14710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NP436_14715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NP436_14725	COG1346	cytolysis
NP436_14730	COG1380	Effector of murein hydrolase LrgA
NP436_14735	COG3279	Response regulator of the LytR AlgR family
NP436_14740	COG3275	phosphorelay sensor kinase activity
NP436_14745	COG1011	Hydrolase
NP436_14750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP436_14760	COG0398	Pfam SNARE associated Golgi protein
NP436_14765	COG1484	DNA-dependent DNA replication
NP436_14770	COG3611	Membrane attachment protein
NP436_14775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NP436_14780	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NP436_14785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP436_14790	COG1733	regulation of RNA biosynthetic process
NP436_14795	COG2814	Major facilitator Superfamily
NP436_14800	COG0656	L-ascorbic acid biosynthetic process
NP436_14805	COG0237	dephospho-CoA kinase activity
NP436_14815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NP436_14820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP436_14820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP436_14825	COG5002	protein histidine kinase activity
NP436_14830	COG0745	RESPONSE REGULATOR receiver
NP436_14835	COG0039	L-malate dehydrogenase activity
NP436_14840	COG0538	isocitrate dehydrogenase activity
NP436_14845	COG0372	Belongs to the citrate synthase family
NP436_14850	COG2707	UPF0756 membrane protein
NP436_14855	COG0628	permease
NP436_14860	COG3030	protein affecting phage T7 exclusion by the F plasmid
NP436_14865	COG0469	pyruvate kinase activity
NP436_14870	COG0205	6-phosphofructokinase activity
NP436_14875	COG0825	malonyl-CoA metabolic process
NP436_14880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NP436_14885	COG0281	malic enzyme
NP436_14890	COG0587	DNA-directed DNA polymerase activity
NP436_14910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NP436_14920	COG4109	DRTGG domain
NP436_14930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NP436_14935	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_14945	COG0165	Argininosuccinate lyase
NP436_14950	COG0137	argininosuccinate synthase activity
NP436_14955	COG0521	Mo-molybdopterin cofactor biosynthetic process
NP436_14960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NP436_14970	COG0827	DNA restriction-modification system
NP436_14975	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NP436_14980	COG3874	Sporulation protein YtfJ
NP436_14990	COG1714	RDD family
NP436_14995	COG0616	signal peptide processing
NP436_15000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP436_15005	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NP436_15010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP436_15020	COG0301	tRNA thio-modification
NP436_15025	COG1104	cysteine desulfurase activity
NP436_15030	COG1114	Component of the transport system for branched-chain amino acids
NP436_15035	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NP436_15040	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP436_15045	COG1309	transcriptional regulator
NP436_15050	COG1956	GAF domain-containing protein
NP436_15060	COG2199	diguanylate cyclase activity
NP436_15060	COG2203	Gaf domain
NP436_15065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NP436_15075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP436_15080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP436_15085	COG0454	-acetyltransferase
NP436_15090	COG0517	IMP dehydrogenase activity
NP436_15095	COG0123	including yeast histone deacetylase and acetoin utilization protein
NP436_15100	COG1360	Flagellar Motor Protein
NP436_15105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP436_15110	COG1609	Transcriptional regulator
NP436_15115	COG1605	Chorismate mutase
NP436_15115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NP436_15120	COG3118	belongs to the thioredoxin family
NP436_15125	COG4980	gas vesicle protein
NP436_15130	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NP436_15135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP436_15140	COG1674	ftsk spoiiie
NP436_15145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP436_15150	COG4848	Belongs to the UPF0354 family
NP436_15155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP436_15170	COG1363	Peptidase, m42
NP436_15175	COG5584	Small secreted protein
NP436_15180	COG0281	malic enzyme
NP436_15185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP436_15190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NP436_15200	COG0510	thiamine kinase activity
NP436_15205	COG1523	belongs to the glycosyl hydrolase 13 family
NP436_15210	COG1597	lipid kinase activity
NP436_15220	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP436_15225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP436_15230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP436_15235	COG2252	PERMEase
NP436_15240	COG4473	ABC transporter
NP436_15245	COG1131	(ABC) transporter
NP436_15250	COG1349	DNA-binding transcription factor activity
NP436_15255	COG1187	pseudouridine synthase activity
NP436_15260	COG2244	polysaccharide biosynthetic process
NP436_15265	COG2081	HI0933 family
NP436_15270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP436_15290	COG1653	transport
NP436_15295	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NP436_15300	COG4209	transmembrane transport
NP436_15310	COG1653	transport
NP436_15315	COG0395	ABC-type sugar transport system, permease component
NP436_15320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP436_15325	COG2124	cytochrome p450
NP436_15345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP436_15355	COG1073	alpha beta
NP436_15360	COG1609	Transcriptional regulator
NP436_15365	COG1653	transport
NP436_15370	COG1175	transmembrane transport
NP436_15375	COG0395	ABC-type sugar transport system, permease component
NP436_15380	COG1486	melibiose metabolic process
NP436_15385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP436_15390	COG0495	leucyl-tRNA aminoacylation
NP436_15400	COG2202	Pas domain
NP436_15400	COG1366	Belongs to the anti-sigma-factor antagonist family
NP436_15405	COG2814	Major facilitator Superfamily
NP436_15410	COG2433	Pfam Transposase IS66
NP436_15415	COG3328	transposase activity
NP436_15425	COG1136	(ABC) transporter
NP436_15430	COG2205	protein histidine kinase activity
NP436_15435	COG0745	RESPONSE REGULATOR receiver
NP436_15440	COG0577	efflux transmembrane transporter activity
NP436_15445	COG1136	(ABC) transporter
NP436_15460	COG1131	(ABC) transporter
NP436_15465	COG1725	Transcriptional regulator
NP436_15490	COG0367	asparagine synthase
NP436_15495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NP436_15500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NP436_15510	COG1506	peptidase
NP436_15515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP436_15520	COG1116	anion transmembrane transporter activity
NP436_15525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP436_15530	COG0494	nUDIX hydrolase
NP436_15535	COG4824	toxin secretion phage lysis holin
NP436_15540	COG0783	Belongs to the Dps family
NP436_15555	COG1854	S-ribosylhomocysteine lyase activity
NP436_15560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NP436_15565	COG0288	reversible hydration of carbon dioxide
NP436_15570	COG0254	rRNA binding
NP436_15575	COG1271	oxidase subunit
NP436_15580	COG1294	oxidase, subunit
NP436_15590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP436_15595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP436_15595	COG1321	iron dependent repressor
NP436_15600	COG1121	(ABC) transporter
NP436_15605	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP436_15610	COG4948	Mandelate Racemase Muconate Lactonizing
NP436_15615	COG0318	PFAM AMP-dependent synthetase and ligase
NP436_15620	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NP436_15625	COG0596	Alpha beta hydrolase
NP436_15630	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NP436_15635	COG1169	isochorismate synthase
NP436_15640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP436_15645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP436_15650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP436_15655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP436_15660	COG0438	transferase activity, transferring glycosyl groups
NP436_15670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP436_15675	COG0438	transferase activity, transferring glycosyl groups
NP436_15680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP436_15685	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NP436_15690	COG0058	SHG alpha-glucan phosphorylase activity
NP436_15695	COG0297	glycogen (starch) synthase activity
NP436_15700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP436_15705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP436_15710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NP436_15835	COG3859	Proton-coupled thiamine transporter YuaJ
NP436_15840	COG1247	-acetyltransferase
NP436_15845	COG2268	Band 7 protein
NP436_15850	COG1585	Membrane protein implicated in regulation of membrane protease activity
NP436_15855	COG2318	DinB family
NP436_15865	COG1454	alcohol dehydrogenase
NP436_15870	COG1012	belongs to the aldehyde dehydrogenase family
NP436_15875	COG1510	regulation of RNA biosynthetic process
NP436_15885	COG0569	domain protein
NP436_15890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP436_15895	COG4682	membrane
NP436_15900	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP436_15905	COG0477	Major facilitator Superfamily
NP436_15910	COG5553	Cysteine dioxygenase type I
NP436_15920	COG1968	undecaprenyl-diphosphatase activity
NP436_15925	COG0628	permease
NP436_15930	COG0673	inositol 2-dehydrogenase activity
NP436_15935	COG4806	L-rhamnose isomerase
NP436_15940	COG3254	rhamnose metabolic process
NP436_15945	COG1070	Carbohydrate kinase
NP436_15950	COG1349	DNA-binding transcription factor activity
NP436_15955	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_15955	COG3347	Dehydrogenase
NP436_15965	COG0840	transmembrane signaling receptor activity
NP436_15975	COG0840	transmembrane signaling receptor activity
NP436_15990	COG0432	Pfam Uncharacterised protein family UPF0047
NP436_16000	COG0366	Alpha amylase catalytic
NP436_16005	COG1253	flavin adenine dinucleotide binding
NP436_16010	COG2738	Putative neutral zinc metallopeptidase
NP436_16025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NP436_16040	COG0166	Belongs to the GPI family
NP436_16045	COG1979	alcohol dehydrogenase
NP436_16050	COG1979	alcohol dehydrogenase
NP436_16055	COG2155	Conserved Protein
NP436_16060	COG1098	S1 RNA binding domain
NP436_16065	COG0436	Aminotransferase
NP436_16070	COG1522	sequence-specific DNA binding
NP436_16075	COG2267	carboxylic ester hydrolase activity
NP436_16085	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NP436_16090	COG2205	protein histidine kinase activity
NP436_16100	COG5018	Exonuclease
NP436_16110	COG2814	Major facilitator Superfamily
NP436_16115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP436_16120	COG3011	Protein conserved in bacteria
NP436_16130	COG3290	protein histidine kinase activity
NP436_16135	COG4565	transcriptional regulatory protein
NP436_16140	COG1744	ABC transporter substrate-binding protein PnrA-like
NP436_16145	COG3845	ABC transporter
NP436_16150	COG4603	Belongs to the binding-protein-dependent transport system permease family
NP436_16155	COG1079	Belongs to the binding-protein-dependent transport system permease family
NP436_16160	COG3493	citrate carrier protein
NP436_16170	COG2111	Na H antiporter
NP436_16170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP436_16175	COG2111	Na H antiporter
NP436_16180	COG1006	Multisubunit Na H antiporter MnhC subunit
NP436_16185	COG0651	ATP synthesis coupled electron transport
NP436_16190	COG1863	multisubunit Na H antiporter MnhE subunit
NP436_16195	COG2212	antiporter activity
NP436_16200	COG1320	monovalent cation:proton antiporter activity
NP436_16205	COG2050	protein possibly involved in aromatic compounds catabolism
NP436_16210	COG2197	response regulator
NP436_16220	COG3328	transposase activity
NP436_16240	COG0142	geranyltranstransferase activity
NP436_16260	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NP436_16265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NP436_16270	COG1335	isochorismatase
NP436_16275	COG5506	Protein of unknown function (DUF1694)
NP436_16290	COG0628	permease
NP436_16305	COG1418	mRNA catabolic process
NP436_16310	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_16320	COG1511	domain protein
NP436_16325	COG1674	ftsk spoiiie
NP436_16325	COG0433	COG0433 Predicted ATPase
NP436_16330	COG3328	transposase activity
NP436_16335	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP436_16340	COG5417	Belongs to the EsaB family
NP436_16345	COG4842	Belongs to the WXG100 family
NP436_16350	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP436_16350	COG2508	Transcriptional regulator
NP436_16355	COG0686	Belongs to the AlaDH PNT family
NP436_16360	COG5634	Uncharacterized conserved protein (DUF2278)
NP436_16365	COG3251	PFAM MbtH domain protein
NP436_16370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP436_16375	COG3433	isochorismatase activity
NP436_16375	COG1535	isochorismatase
NP436_16380	COG1021	2,3-dihydroxybenzoate-AMP ligase
NP436_16385	COG1169	isochorismate synthase
NP436_16390	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_16395	COG2819	hydrolase of the alpha beta superfamily
NP436_16400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP436_16405	COG1268	BioY protein
NP436_16410	COG2056	Na+-H+ antiporter family
NP436_16415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NP436_16420	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NP436_16425	COG3584	3D domain protein
NP436_16440	COG1252	NADH dehydrogenase
NP436_16445	COG0492	ferredoxin-NADP+ reductase activity
NP436_16455	COG0516	GMP reductase activity
NP436_16460	COG2808	Putative FMN-binding domain
NP436_16465	COG0456	acetyltransferase
NP436_16575	COG0582	viral genome integration into host DNA
NP436_16585	COG4974	Belongs to the 'phage' integrase family
NP436_16590	COG0316	Belongs to the HesB IscA family
NP436_16595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NP436_16600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP436_16605	COG4844	belongs to the
NP436_16610	COG1252	NADH dehydrogenase
NP436_16615	COG4837	Protein of unknown function (DUF1462)
NP436_16620	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NP436_16625	COG4946	Tricorn protease homolog
NP436_16625	COG1506	peptidase
NP436_16625	COG0823	Involved in the tonB-independent uptake of proteins
NP436_16630	COG0083	homoserine kinase activity
NP436_16635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NP436_16640	COG0460	homoserine dehydrogenase
NP436_16645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP436_16650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP436_16655	COG0647	UMP catabolic process
NP436_16660	COG2445	Protein of unknown function DUF86
NP436_16665	COG4470	Protein conserved in bacteria
NP436_16675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NP436_16680	COG0739	heme binding
NP436_16690	COG3377	Domain of unknown function (DUF1805)
NP436_16695	COG0737	Belongs to the 5'-nucleotidase family
NP436_16700	COG0730	response to heat
NP436_16705	COG1801	Protein of unknown function DUF72
NP436_16715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP436_16720	COG2508	Transcriptional regulator
NP436_16725	COG2233	PERMEase
NP436_16730	COG2233	PERMEase
NP436_16735	COG3195	allantoin biosynthetic process
NP436_16735	COG3648	Uricase
NP436_16740	COG2351	hydroxyisourate hydrolase activity
NP436_16750	COG2080	2 iron, 2 sulfur cluster binding
NP436_16755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NP436_16760	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NP436_16765	COG2068	MobA-Related Protein
NP436_16770	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NP436_16775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NP436_16780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP436_16790	COG2356	endonuclease I
NP436_16795	COG3842	ATPase activity
NP436_16800	COG2188	Transcriptional regulator
NP436_16805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP436_16815	COG1175	transmembrane transport
NP436_16820	COG1653	transport
NP436_16825	COG2222	sugar isomerase
NP436_16830	COG0322	excinuclease ABC activity
NP436_16835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP436_16850	COG0346	lactoylglutathione lyase activity
NP436_16855	COG0640	Transcriptional regulator
NP436_16860	COG0719	Fe-S assembly protein
NP436_16865	COG0822	iron-sulfur transferase activity
NP436_16870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP436_16875	COG0719	Fe-S assembly protein
NP436_16880	COG0396	ATPase activity
NP436_16895	COG1464	Belongs to the NlpA lipoprotein family
NP436_16900	COG2011	ABC-type metal ion transport system permease component
NP436_16905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NP436_16915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP436_16920	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP436_16930	COG0509	glycine decarboxylation via glycine cleavage system
NP436_16935	COG1393	Belongs to the ArsC family
NP436_16940	COG1960	acyl-CoA dehydrogenase activity
NP436_16945	COG0183	Belongs to the thiolase family
NP436_16950	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP436_16950	COG1024	Enoyl-CoA hydratase
NP436_16970	COG5577	PFAM Coat F domain
NP436_16975	COG1846	Transcriptional regulator
NP436_16980	COG0477	Major facilitator Superfamily
NP436_16985	COG1942	4-Oxalocrotonate Tautomerase
NP436_16990	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_16995	COG0583	DNA-binding transcription factor activity
NP436_17005	COG1120	ATPase activity
NP436_17030	COG1131	(ABC) transporter
NP436_17075	COG0783	Belongs to the Dps family
NP436_17080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP436_17085	COG0745	RESPONSE REGULATOR receiver
NP436_17090	COG2770	Histidine kinase
NP436_17090	COG2205	protein histidine kinase activity
NP436_17100	COG1309	transcriptional regulator
NP436_17105	COG0114	fumarate hydratase activity
NP436_17115	COG0697	spore germination
NP436_17120	COG0814	amino acid
NP436_17130	COG2197	response regulator
NP436_17135	COG4585	Histidine kinase
NP436_17140	COG4758	membrane
NP436_17145	COG3595	metallopeptidase activity
NP436_17150	COG1842	Phage shock protein A
NP436_17155	COG4758	membrane
NP436_17160	COG2814	Major facilitator Superfamily
NP436_17165	COG2096	Adenosyltransferase
NP436_17170	COG1120	ATPase activity
NP436_17175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP436_17180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP436_17185	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_17190	COG3386	PFAM SMP-30 Gluconolaconase
NP436_17195	COG2205	protein histidine kinase activity
NP436_17200	COG0745	RESPONSE REGULATOR receiver
NP436_17220	COG2140	Oxalate decarboxylase
NP436_17230	COG0577	efflux transmembrane transporter activity
NP436_17235	COG1136	(ABC) transporter
NP436_17240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP436_17245	COG1120	ATPase activity
NP436_17250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP436_17255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP436_17260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP436_17265	COG0531	amino acid
NP436_17275	COG1988	membrane-bound metal-dependent
NP436_17280	COG1368	sulfuric ester hydrolase activity
NP436_17285	COG1910	domain protein
NP436_17290	COG0725	ABC transporter, periplasmic molybdate-binding protein
NP436_17295	COG4149	molybdate abc transporter
NP436_17300	COG0656	L-ascorbic acid biosynthetic process
NP436_17310	COG0025	NhaP-type Na H and K H
NP436_17315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP436_17320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP436_17325	COG3973	AAA domain
NP436_17335	COG2860	membrane
NP436_17340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NP436_17345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP436_17350	COG2217	Heavy metal translocating P-type atpase
NP436_17355	COG2217	Heavy metal translocating P-type atpase
NP436_17360	COG2608	mercury ion transmembrane transporter activity
NP436_17365	COG1937	Protein conserved in bacteria
NP436_17370	COG0673	inositol 2-dehydrogenase activity
NP436_17380	COG1289	transmembrane transporter activity
NP436_17390	COG2076	Multidrug Resistance protein
NP436_17395	COG1309	transcriptional regulator
NP436_17400	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_17410	COG5444	nuclease activity
NP436_17425	COG3409	Peptidoglycan-binding domain 1 protein
NP436_17425	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP436_17430	COG4824	toxin secretion phage lysis holin
NP436_17455	COG3942	CHAP domain
NP436_17455	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP436_17700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NP436_17705	COG0557	exoribonuclease II activity
NP436_17710	COG1647	Serine aminopeptidase, S33
NP436_17715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP436_17720	COG0596	Alpha beta hydrolase
NP436_17725	COG1476	TRANSCRIPTIONal
NP436_17730	COG1396	sequence-specific DNA binding
NP436_17735	COG1396	sequence-specific DNA binding
NP436_17740	COG1733	regulation of RNA biosynthetic process
NP436_17745	COG0840	transmembrane signaling receptor activity
NP436_17750	COG1174	glycine betaine transport
NP436_17755	COG1732	Glycine betaine
NP436_17760	COG1174	glycine betaine transport
NP436_17765	COG1125	glycine betaine transport
NP436_17765	COG0517	IMP dehydrogenase activity
NP436_17770	COG1510	regulation of RNA biosynthetic process
NP436_17775	COG1174	glycine betaine transport
NP436_17780	COG1732	Glycine betaine
NP436_17785	COG1174	glycine betaine transport
NP436_17790	COG1125	glycine betaine transport
NP436_17790	COG0517	IMP dehydrogenase activity
NP436_17795	COG1510	regulation of RNA biosynthetic process
NP436_17800	COG2095	MarC family integral membrane protein
NP436_17810	COG3064	Membrane
NP436_17815	COG4640	response to antibiotic
NP436_17820	COG0456	acetyltransferase
NP436_17825	COG0148	phosphopyruvate hydratase activity
NP436_17830	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NP436_17835	COG0149	triose-phosphate isomerase activity
NP436_17840	COG0126	phosphoglycerate kinase activity
NP436_17845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP436_17850	COG2390	Transcriptional regulator
NP436_17855	COG2814	Major facilitator Superfamily
NP436_17860	COG1609	Transcriptional regulator
NP436_17865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP436_17870	COG0583	DNA-binding transcription factor activity
NP436_17875	COG0697	spore germination
NP436_17880	COG1113	amino acid transport
NP436_17890	COG1556	Lactate utilization protein
NP436_17895	COG1139	Iron-sulfur cluster binding protein
NP436_17900	COG0247	lactate metabolic process
NP436_17905	COG2197	response regulator
NP436_17910	COG4585	Histidine kinase
NP436_17915	COG0842	Transport permease protein
NP436_17920	COG1131	(ABC) transporter
NP436_17940	COG0596	Alpha beta hydrolase
NP436_17945	COG2208	phosphoserine phosphatase activity
NP436_17950	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NP436_17955	COG1874	Beta-galactosidase
NP436_17960	COG3833	ABC-type maltose transport systems, permease component
NP436_17965	COG1175	transmembrane transport
NP436_17970	COG2182	Extracellular solute-binding protein
NP436_17975	COG1609	Transcriptional regulator
NP436_17980	COG2186	Transcriptional regulator
NP436_17985	COG1620	l-lactate permease
NP436_17990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NP436_18000	COG5039	Polysaccharide pyruvyl transferase
NP436_18005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP436_18010	COG0110	maltose O-acetyltransferase activity
NP436_18015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP436_18020	COG2244	polysaccharide biosynthetic process
NP436_18025	COG1216	Glycosyl transferase, family 2
NP436_18030	COG5039	Polysaccharide pyruvyl transferase
NP436_18035	COG1216	Glycosyl transferase, family 2
NP436_18045	COG0438	transferase activity, transferring glycosyl groups
NP436_18050	COG1215	transferase activity, transferring glycosyl groups
NP436_18055	COG0438	transferase activity, transferring glycosyl groups
NP436_18060	COG1086	Polysaccharide biosynthesis protein
NP436_18065	COG0489	protein tyrosine kinase activity
NP436_18070	COG3944	biosynthesis protein
NP436_18075	COG1396	sequence-specific DNA binding
NP436_18080	COG2272	Belongs to the type-B carboxylesterase lipase family
NP436_18090	COG3479	Phenolic acid decarboxylase
NP436_18105	COG1794	racemase activity, acting on amino acids and derivatives
NP436_18115	COG1621	beta-fructofuranosidase activity
NP436_18120	COG1621	beta-fructofuranosidase activity
NP436_18125	COG0531	amino acid
NP436_18130	COG1309	transcriptional regulator
NP436_18135	COG2076	Multidrug Resistance protein
NP436_18140	COG2076	Multidrug Resistance protein
NP436_18160	COG1674	ftsk spoiiie
NP436_18180	COG1388	LysM domain
NP436_18180	COG3409	Peptidoglycan-binding domain 1 protein
NP436_18180	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP436_18215	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP436_18295	COG0582	viral genome integration into host DNA
NP436_18410	COG4974	Belongs to the 'phage' integrase family
NP436_18420	COG0740	serine-type endopeptidase activity
NP436_18425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP436_18430	COG0366	Alpha amylase catalytic
NP436_18435	COG1554	hydrolase, family 65, central catalytic
NP436_18440	COG5521	maltodextrose utilization protein MalA
NP436_18445	COG3833	ABC-type maltose transport systems, permease component
NP436_18450	COG1175	transmembrane transport
NP436_18455	COG2182	Extracellular solute-binding protein
NP436_18465	COG1609	Transcriptional regulator
NP436_18470	COG1611	Belongs to the LOG family
NP436_18480	COG0659	secondary active sulfate transmembrane transporter activity
NP436_18485	COG0288	reversible hydration of carbon dioxide
NP436_18490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP436_18495	COG0577	efflux transmembrane transporter activity
NP436_18500	COG1136	(ABC) transporter
NP436_18505	COG5002	protein histidine kinase activity
NP436_18510	COG0745	RESPONSE REGULATOR receiver
NP436_18520	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NP436_18525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP436_18530	COG1481	regulation of sporulation
NP436_18535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NP436_18540	COG1660	Displays ATPase and GTPase activities
NP436_18545	COG1051	belongs to the nudix hydrolase family
NP436_18550	COG0492	ferredoxin-NADP+ reductase activity
NP436_18555	COG0791	NLP P60 protein
NP436_18555	COG3883	PFAM NLP P60 protein
NP436_18560	COG0457	Tetratricopeptide repeat
NP436_18565	COG1132	(ABC) transporter
NP436_18585	COG0140	phosphoribosyl-ATP diphosphatase activity
NP436_18585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NP436_18590	COG0107	imidazoleglycerol-phosphate synthase activity
NP436_18595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NP436_18600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NP436_18605	COG0131	Imidazoleglycerol-phosphate dehydratase
NP436_18610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NP436_18615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NP436_18620	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NP436_18625	COG4990	cell redox homeostasis
NP436_18630	COG5297	Belongs to the glycosyl hydrolase family 6
NP436_18645	COG0546	phosphoglycolate phosphatase activity
NP436_18650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NP436_18655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NP436_18660	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NP436_18665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NP436_18670	COG0363	glucosamine-6-phosphate deaminase activity
NP436_18675	COG2188	Transcriptional regulator
NP436_18680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NP436_18695	COG1950	PFAM Membrane protein of
NP436_18700	COG1983	PspC domain protein
NP436_18705	COG3595	metallopeptidase activity
NP436_18720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP436_18725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NP436_18730	COG0556	nucleotide-excision repair
NP436_18735	COG4897	Protein conserved in bacteria
NP436_18740	COG0574	Belongs to the PEP-utilizing enzyme family
NP436_18740	COG3848	Pyruvate phosphate dikinase
NP436_18745	COG1309	transcriptional regulator
NP436_18750	COG2814	Major facilitator Superfamily
NP436_18755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP436_18765	COG3409	Peptidoglycan-binding domain 1 protein
NP436_18765	COG0793	Belongs to the peptidase S41A family
NP436_18770	COG2177	Part of the ABC transporter FtsEX involved in
NP436_18775	COG2884	Cell division ATP-binding protein ftsE
NP436_18780	COG2010	Cytochrome c
NP436_18785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP436_18795	COG0653	protein targeting
NP436_18800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP436_18815	COG1516	flagellar protein fliS
NP436_18820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NP436_18825	COG1334	flagellar protein FlaG
NP436_18830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP436_18835	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NP436_18840	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NP436_18850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP436_18855	COG1256	bacterial-type flagellum assembly
NP436_18855	COG4786	Flagellar basal body rod
NP436_18860	COG3418	PFAM FlgN family protein
NP436_18865	COG2747	anti-sigma28 factor FlgM
NP436_18875	COG1040	competence protein
NP436_18885	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NP436_18890	COG1307	EDD domain protein, DegV family
NP436_18895	COG2197	response regulator
NP436_18900	COG4585	Histidine kinase
NP436_18905	COG1739	Uncharacterized protein family UPF0029
NP436_18940	COG1131	(ABC) transporter
NP436_18950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP436_18955	COG0438	transferase activity, transferring glycosyl groups
NP436_18960	COG1215	transferase activity, transferring glycosyl groups
NP436_18965	COG3206	protein involved in exopolysaccharide biosynthesis
NP436_18970	COG3307	-O-antigen
NP436_18975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP436_18980	COG0297	glycogen (starch) synthase activity
NP436_18980	COG0438	transferase activity, transferring glycosyl groups
NP436_18985	COG2244	polysaccharide biosynthetic process
NP436_19000	COG2247	cell wall binding repeat
NP436_19000	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP436_19005	COG2385	sporulation resulting in formation of a cellular spore
NP436_19005	COG2247	cell wall binding repeat
NP436_19035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NP436_19040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP436_19055	COG1682	transport, permease protein
NP436_19065	COG0463	Glycosyl transferase, family 2
NP436_19065	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP436_19070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP436_19075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NP436_19080	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NP436_19085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP436_19090	COG4193	domain, Protein
NP436_19095	COG1482	cell wall glycoprotein biosynthetic process
NP436_19100	COG0697	spore germination
NP436_19105	COG0814	amino acid
NP436_19120	COG1316	TRANSCRIPTIONal
NP436_19125	COG0561	phosphatase activity
NP436_19130	COG0791	NLP P60 protein
NP436_19140	COG2843	Capsule synthesis protein
NP436_19150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP436_19155	COG1609	Transcriptional regulator
NP436_19160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP436_19165	COG1869	D-ribose catabolic process
NP436_19170	COG1129	ABC transporter
NP436_19175	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP436_19180	COG1879	ABC-type sugar transport system periplasmic component
NP436_19185	COG3103	Sh3 type 3 domain protein
NP436_19195	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP436_19205	COG3527	Alpha-acetolactate decarboxylase
NP436_19210	COG0028	Belongs to the TPP enzyme family
NP436_19215	COG0583	DNA-binding transcription factor activity
NP436_19220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP436_19235	COG5337	Spore coat protein CotH
NP436_19245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP436_19255	COG0405	Gamma-glutamyltransferase
NP436_19260	COG1522	sequence-specific DNA binding
NP436_19265	COG2059	Chromate
NP436_19270	COG2059	Chromate
NP436_19280	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP436_19285	COG0583	DNA-binding transcription factor activity
NP436_19345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP436_19350	COG4464	protein tyrosine phosphatase activity
NP436_19355	COG0489	protein tyrosine kinase activity
NP436_19360	COG3944	biosynthesis protein
NP436_19370	COG4715	Zinc finger, swim domain protein
NP436_19375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP436_19380	COG0561	phosphatase activity
NP436_19385	COG1349	DNA-binding transcription factor activity
NP436_19390	COG0629	single-stranded DNA binding
NP436_19415	COG2972	Histidine kinase
NP436_19415	COG0745	RESPONSE REGULATOR receiver
NP436_19420	COG1970	mechanosensitive ion channel activity
NP436_19425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP436_19430	COG0457	Tetratricopeptide repeat
NP436_19435	COG4786	Flagellar basal body rod
NP436_19440	COG4786	Flagellar basal body rod
NP436_19445	COG1077	Cell shape determining protein MreB Mrl
NP436_19450	COG1609	Transcriptional regulator
NP436_19460	COG1846	Transcriptional regulator
NP436_19465	COG2814	Major facilitator Superfamily
NP436_19470	COG3420	alginic acid biosynthetic process
NP436_19475	COG1953	Uracil, thiamine, allantoin
NP436_19480	COG0477	Major facilitator Superfamily
NP436_19485	COG1335	isochorismatase
NP436_19495	COG0004	ammonium transporteR
NP436_19500	COG0347	Belongs to the P(II) protein family
NP436_19505	COG0671	phosphoesterase, PA-phosphatase related
NP436_19515	COG0739	heme binding
NP436_19520	COG1247	-acetyltransferase
NP436_19530	COG2089	acid synthase
NP436_19540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP436_19545	COG0789	Transcriptional regulator
NP436_19555	COG2910	NAD(P)H-binding
NP436_19560	COG1959	2 iron, 2 sulfur cluster binding
NP436_19565	COG0804	urea catabolic process
NP436_19570	COG0832	Belongs to the urease beta subunit family
NP436_19575	COG0831	urea catabolic process
NP436_19590	COG3237	CsbD-like
NP436_19595	COG1994	Peptidase M50
NP436_19600	COG0457	Tetratricopeptide repeat
NP436_19605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NP436_19610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NP436_19620	COG2304	oxidoreductase activity
NP436_19630	COG2304	oxidoreductase activity
NP436_19635	COG2385	sporulation resulting in formation of a cellular spore
NP436_19640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP436_19650	COG4836	Membrane
NP436_19660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NP436_19665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NP436_19670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NP436_19675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NP436_19680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP436_19685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NP436_19695	COG0356	it plays a direct role in the translocation of protons across the membrane
NP436_19705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NP436_19710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP436_19715	COG4475	Protein of unknown function (DUF436)
NP436_19720	COG0698	ribose 5-phosphate isomerase
NP436_19725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP436_19730	COG1971	Probably functions as a manganese efflux pump
NP436_19735	COG0009	L-threonylcarbamoyladenylate synthase
NP436_19740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NP436_19760	COG2890	protein-(glutamine-N5) methyltransferase activity
NP436_19765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NP436_19770	COG0346	lactoylglutathione lyase activity
NP436_19775	COG0789	Transcriptional regulator
NP436_19780	COG0679	Auxin Efflux Carrier
NP436_19785	COG0281	malic enzyme
NP436_19790	COG1435	thymidine kinase activity
NP436_19800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NP436_19810	COG1494	fructose-1,6-bisphosphatase
NP436_19815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP436_19825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NP436_19830	COG0191	fructose-bisphosphate aldolase activity
NP436_19835	COG2204	response regulator
NP436_19840	COG4821	SIS domain
NP436_19845	COG0504	CTP synthase activity
NP436_19850	COG3343	RNA polymerase activity
NP436_19855	COG1960	acyl-CoA dehydrogenase activity
NP436_19860	COG0247	lactate metabolic process
NP436_19860	COG2181	nitrate reductase activity
NP436_19865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP436_19870	COG4294	response to UV
NP436_19880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP436_19890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP436_19900	COG2181	nitrate reductase activity
NP436_19905	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NP436_19910	COG1140	nitrate reductase beta subunit
NP436_19915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NP436_19920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP436_19930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP436_19935	COG2223	nitrite transmembrane transporter activity
NP436_19940	COG0018	arginyl-trna synthetase
NP436_19945	COG4506	Protein conserved in bacteria
NP436_19960	COG0535	radical SAM domain protein
NP436_19970	COG1131	(ABC) transporter
NP436_19975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP436_19980	COG0612	Peptidase, M16
NP436_19985	COG0612	Peptidase, M16
NP436_19995	COG3391	amine dehydrogenase activity
NP436_20000	COG3391	amine dehydrogenase activity
NP436_20005	COG0457	Tetratricopeptide repeat
NP436_20020	COG0010	Belongs to the arginase family
NP436_20025	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NP436_20030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP436_20045	COG1994	Peptidase M50
NP436_20050	COG1942	4-Oxalocrotonate Tautomerase
NP436_20055	COG1846	Transcriptional regulator
NP436_20060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP436_20065	COG0477	Major facilitator Superfamily
NP436_20070	COG1959	2 iron, 2 sulfur cluster binding
NP436_20075	COG3465	dGTPase activity
NP436_20080	COG1078	dGTPase activity
NP436_20085	COG4844	belongs to the
NP436_20095	COG0697	spore germination
NP436_20100	COG0095	Lipoate-protein ligase
NP436_20105	COG0583	DNA-binding transcription factor activity
NP436_20110	COG0280	phosphate acetyltransferase
NP436_20115	COG3253	May function as heme-dependent peroxidase
NP436_20120	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_20125	COG0436	Aminotransferase
NP436_20130	COG2814	Major facilitator Superfamily
NP436_20135	COG0151	Belongs to the GarS family
NP436_20140	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_20145	COG1917	Cupin 2, conserved barrel domain protein
NP436_20150	COG0077	Prephenate dehydratase
NP436_20155	COG2814	Major facilitator Superfamily
NP436_20160	COG0833	amino acid
NP436_20165	COG4187	Peptidase family M20/M25/M40
NP436_20170	COG1012	belongs to the aldehyde dehydrogenase family
NP436_20175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP436_20185	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NP436_20190	COG1091	dTDP-4-dehydrorhamnose reductase activity
NP436_20195	COG1088	dTDP-glucose 4,6-dehydratase activity
NP436_20200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NP436_20205	COG3980	spore coat polysaccharide biosynthesis protein
NP436_20210	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NP436_20215	COG2089	acid synthase
NP436_20220	COG0456	acetyltransferase
NP436_20225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP436_20230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP436_20235	COG0463	Glycosyl transferase, family 2
NP436_20245	COG2363	Small membrane protein
NP436_20250	COG2233	PERMEase
NP436_20260	COG1012	belongs to the aldehyde dehydrogenase family
NP436_20265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NP436_20270	COG1216	Glycosyl transferase, family 2
NP436_20275	COG0351	phosphomethylpyrimidine kinase
NP436_20285	COG1621	beta-fructofuranosidase activity
NP436_20290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_20290	COG1263	PTS System
NP436_20295	COG2116	formate transmembrane transporter activity
NP436_20310	COG1404	Belongs to the peptidase S8 family
NP436_20315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP436_20320	COG0778	Nitroreductase
NP436_20325	COG0772	Belongs to the SEDS family
NP436_20340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP436_20345	COG1845	cytochrome c oxidase, subunit III
NP436_20350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP436_20355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP436_20360	COG2261	transglycosylase associated protein
NP436_20365	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NP436_20370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NP436_20375	COG2246	polysaccharide biosynthetic process
NP436_20380	COG1309	transcriptional regulator
NP436_20390	COG3162	membrane
NP436_20395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP436_20400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP436_20405	COG2837	iron assimilation
NP436_20410	COG2822	iron ion transport
NP436_20415	COG0672	)-iron permease
NP436_20420	COG0352	thiamine-phosphate diphosphorylase activity
NP436_20425	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NP436_20430	COG0583	DNA-binding transcription factor activity
NP436_20435	COG1380	Effector of murein hydrolase LrgA
NP436_20440	COG1346	cytolysis
NP436_20445	COG2814	Major facilitator Superfamily
NP436_20450	COG4895	conserved protein (DUF2196)
NP436_20455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NP436_20460	COG0346	lactoylglutathione lyase activity
NP436_20480	COG1263	PTS System
NP436_20480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_20485	COG3711	transcriptional antiterminator
NP436_20490	COG1442	glycosyl transferase family 8
NP436_20495	COG5522	Integral membrane protein (intg_mem_TP0381)
NP436_20500	COG1846	Transcriptional regulator
NP436_20505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP436_20510	COG2234	aminopeptidase activity
NP436_20515	COG2357	RelA SpoT domain protein
NP436_20525	COG1575	Belongs to the MenA family. Type 1 subfamily
NP436_20540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP436_20545	COG1696	Membrane protein involved in D-alanine export
NP436_20550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP436_20555	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NP436_20570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP436_20575	COG1486	melibiose metabolic process
NP436_20580	COG1447	Phosphotransferase system cellobiose-specific component IIA
NP436_20585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP436_20590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP436_20595	COG3711	transcriptional antiterminator
NP436_20595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP436_20605	COG2094	Belongs to the DNA glycosylase MPG family
NP436_20610	COG0753	catalase activity
NP436_20615	COG2814	Major facilitator Superfamily
NP436_20620	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP436_20625	COG1131	(ABC) transporter
NP436_20645	COG1595	DNA-templated transcription, initiation
NP436_20650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NP436_20655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NP436_20660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NP436_20665	COG4988	ABC transporter
NP436_20670	COG1294	oxidase, subunit
NP436_20675	COG1271	oxidase subunit
NP436_20680	COG3493	citrate carrier protein
NP436_20685	COG0501	Belongs to the peptidase M48B family
NP436_20695	COG0726	polysaccharide deacetylase
NP436_20700	COG3842	ATPase activity
NP436_20705	COG2508	Transcriptional regulator
NP436_20710	COG1012	belongs to the aldehyde dehydrogenase family
NP436_20715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP436_20720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NP436_20730	COG4585	Histidine kinase
NP436_20735	COG2197	response regulator
NP436_20740	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP436_20755	COG4894	glucomannan catabolic process
NP436_20760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP436_20765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP436_20770	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_20775	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP436_20780	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP436_20785	COG2610	gluconate transmembrane transporter activity
NP436_20790	COG0500	methyltransferase
NP436_20795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP436_20810	COG0693	protein deglycase activity
NP436_20810	COG0753	catalase activity
NP436_20815	COG2851	Citrate transporter
NP436_20820	COG2273	Hydrolase Family 16
NP436_20825	COG3711	transcriptional antiterminator
NP436_20835	COG2270	Major facilitator Superfamily
NP436_20840	COG0513	Belongs to the DEAD box helicase family
NP436_20845	COG3401	FG-GAP repeat protein
NP436_20845	COG2755	lipolytic protein G-D-S-L family
NP436_20965	COG0697	spore germination
NP436_20980	COG0589	response to stress
NP436_20990	COG2190	(PTS) system
NP436_20990	COG1263	PTS System
NP436_20990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP436_21010	COG5444	nuclease activity
NP436_21030	COG3328	transposase activity
NP436_21035	COG0494	nUDIX hydrolase
NP436_21040	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NP436_21045	COG3507	Belongs to the glycosyl hydrolase 43 family
NP436_21060	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NP436_21065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP436_21070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NP436_21075	COG2390	Transcriptional regulator
NP436_21085	COG3192	ethanolamine utilization protein
NP436_21090	COG2079	MmgE PrpD family protein
NP436_21095	COG1473	amidohydrolase
NP436_21100	COG1126	abc transporter atp-binding protein
NP436_21105	COG0765	amino acid transport
NP436_21110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP436_21115	COG0456	acetyltransferase
NP436_21120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP436_21125	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
NP436_21130	COG0561	phosphatase activity
NP436_21160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP436_21165	COG5294	Protein conserved in bacteria
NP436_21180	COG2205	protein histidine kinase activity
NP436_21185	COG0745	RESPONSE REGULATOR receiver
NP436_21190	COG0191	fructose-bisphosphate aldolase activity
NP436_21195	COG1082	Xylose isomerase domain protein TIM barrel
NP436_21200	COG1082	Xylose isomerase domain protein TIM barrel
NP436_21205	COG0673	inositol 2-dehydrogenase activity
NP436_21210	COG2814	Major facilitator Superfamily
NP436_21215	COG1082	Xylose isomerase domain protein TIM barrel
NP436_21220	COG3962	Belongs to the TPP enzyme family
NP436_21225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP436_21245	COG1349	DNA-binding transcription factor activity
NP436_21250	COG0667	Aldo Keto reductase
NP436_21280	COG0326	Molecular chaperone. Has ATPase activity
NP436_21335	COG1917	Cupin 2, conserved barrel domain protein
NP436_21340	COG1309	transcriptional regulator
NP436_21345	COG1028	Short-chain dehydrogenase reductase Sdr
NP436_21355	COG1846	Transcriptional regulator
NP436_21360	COG1380	Effector of murein hydrolase LrgA
NP436_21365	COG1346	cytolysis
NP436_21370	COG5039	Polysaccharide pyruvyl transferase
NP436_21375	COG1929	Belongs to the glycerate kinase type-1 family
NP436_21380	COG1802	Transcriptional regulator
NP436_21385	COG1070	Carbohydrate kinase
NP436_21390	COG2610	gluconate transmembrane transporter activity
NP436_21395	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP436_21400	COG0450	alkyl hydroperoxide reductase
NP436_21405	COG3634	alkyl hydroperoxide reductase activity
NP436_21410	COG2723	6-phospho-beta-galactosidase activity
NP436_21415	COG2190	(PTS) system
NP436_21425	COG2188	Transcriptional regulator
NP436_21435	COG1131	(ABC) transporter
NP436_21440	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NP436_21450	COG0071	Belongs to the small heat shock protein (HSP20) family
NP436_21480	COG0210	DNA helicase
NP436_21510	COG2963	transposase activity
NP436_21545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NP436_21560	COG1063	alcohol dehydrogenase
NP436_21580	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NP436_21585	COG0456	acetyltransferase
NP436_21590	COG0457	Tetratricopeptide repeat
NP436_21600	COG0010	Belongs to the arginase family
NP436_21605	COG0833	amino acid
NP436_21610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP436_21630	COG5658	integral membrane protein
NP436_21635	COG0640	Transcriptional regulator
NP436_21640	COG3829	transcription factor binding
NP436_21655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP436_21660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NP436_21665	COG4853	Protein conserved in bacteria
NP436_21670	COG4863	YycH protein
NP436_21675	COG5002	protein histidine kinase activity
NP436_21680	COG0745	RESPONSE REGULATOR receiver
NP436_21710	COG0346	lactoylglutathione lyase activity
NP436_21715	COG0305	Participates in initiation and elongation during chromosome replication
NP436_21730	COG3093	addiction module antidote protein HigA
NP436_21735	COG2807	transmembrane transport
NP436_21740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP436_21745	COG0359	binds to the 23S rRNA
NP436_21750	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NP436_21755	COG4241	membrane
NP436_21770	COG1733	regulation of RNA biosynthetic process
NP436_21775	COG1227	inorganic diphosphatase activity
NP436_21785	COG2271	Major facilitator Superfamily
NP436_21790	COG4978	Transcriptional regulator
NP436_21790	COG0789	Transcriptional regulator
NP436_21800	COG4319	ketosteroid isomerase
NP436_21805	COG1357	PFAM Pentapeptide repeats (8 copies)
NP436_21820	COG1846	Transcriptional regulator
NP436_21825	COG2153	protein acetylation
NP436_21830	COG2364	Membrane
NP436_21835	COG0456	acetyltransferase
NP436_21840	COG2315	Protein conserved in bacteria
NP436_21845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP436_21855	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NP436_21860	COG1331	Highly conserved protein containing a thioredoxin domain
NP436_21865	COG1266	CAAX protease self-immunity
NP436_21870	COG0477	Major facilitator Superfamily
NP436_21870	COG2814	Major facilitator Superfamily
NP436_21875	COG0346	lactoylglutathione lyase activity
NP436_21880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP436_21885	COG0542	response to heat
NP436_21900	COG0708	Exodeoxyribonuclease III
NP436_21905	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NP436_21910	COG0629	single-stranded DNA binding
NP436_21915	COG0360	Binds together with S18 to 16S ribosomal RNA
NP436_21920	COG0012	GTP binding
NP436_21925	COG0243	molybdopterin cofactor binding
NP436_21930	COG4481	Protein conserved in bacteria
NP436_21935	COG3949	Membrane
NP436_21945	COG1475	DNA binding
NP436_21950	COG1192	Involved in chromosome partitioning
NP436_21960	COG1475	DNA binding
NP436_21965	COG0357	Ribosomal RNA small subunit methyltransferase G
NP436_21970	COG0445	tRNA wobble uridine modification
NP436_21975	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NP436_21980	COG1847	R3H domain protein
NP436_21985	COG0706	membrane insertase activity
NP436_21990	COG0594	ribonuclease P activity