locus-tag	class	description
NP437_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NP437_00010	COG0592	DNA-directed DNA polymerase activity
NP437_00015	COG2501	S4 domain
NP437_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NP437_00030	COG0187	DNA topoisomerase II activity
NP437_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP437_00070	COG0516	GMP reductase activity
NP437_00070	COG0517	IMP dehydrogenase activity
NP437_00075	COG1686	Belongs to the peptidase S11 family
NP437_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NP437_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NP437_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NP437_00100	COG1428	Deoxynucleoside kinase
NP437_00105	COG1428	Deoxynucleoside kinase
NP437_00110	COG1388	LysM domain
NP437_00110	COG3858	chitin binding
NP437_00115	COG1335	isochorismatase
NP437_00120	COG0590	tRNA wobble adenosine to inosine editing
NP437_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NP437_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NP437_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NP437_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NP437_00190	COG3853	Toxic anion resistance protein (TelA)
NP437_00195	COG1982	Orn Lys Arg decarboxylase major
NP437_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NP437_00205	COG3870	Protein conserved in bacteria
NP437_00210	COG1728	Protein conserved in bacteria
NP437_00215	COG0470	DNA polymerase III
NP437_00220	COG1774	PSP1 C-terminal conserved region
NP437_00225	COG4467	Involved in initiation control of chromosome replication
NP437_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NP437_00235	COG2827	Endonuclease containing a URI domain
NP437_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NP437_00245	COG2002	toxin-antitoxin pair type II binding
NP437_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP437_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP437_00255	COG0084	hydrolase, TatD family'
NP437_00260	COG3583	domain protein
NP437_00260	COG3584	3D domain protein
NP437_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP437_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NP437_00280	COG4466	Protein conserved in bacteria
NP437_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NP437_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP437_00300	COG0251	oxidation-reduction process
NP437_00305	COG2088	sporulation resulting in formation of a cellular spore
NP437_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NP437_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NP437_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NP437_00325	COG0193	aminoacyl-tRNA hydrolase activity
NP437_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NP437_00340	COG2002	toxin-antitoxin pair type II binding
NP437_00345	COG2244	polysaccharide biosynthetic process
NP437_00350	COG3956	TIGRFAM MazG family protein
NP437_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NP437_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NP437_00375	COG1098	S1 RNA binding domain
NP437_00390	COG2208	phosphoserine phosphatase activity
NP437_00395	COG2304	oxidoreductase activity
NP437_00400	COG0515	serine threonine protein kinase
NP437_00405	COG0037	tRNA processing
NP437_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NP437_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP437_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NP437_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NP437_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP437_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP437_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP437_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
NP437_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP437_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NP437_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NP437_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP437_00470	COG1396	sequence-specific DNA binding
NP437_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP437_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NP437_00560	COG4463	regulation of RNA biosynthetic process
NP437_00565	COG3880	PFAM UvrB UvrC protein
NP437_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
NP437_00575	COG0542	response to heat
NP437_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NP437_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NP437_00590	COG4956	integral membrane protein (PIN domain superfamily)
NP437_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NP437_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NP437_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP437_00610	COG1045	serine acetyltransferase
NP437_00615	COG0215	cysteine-tRNA ligase activity
NP437_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NP437_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP437_00630	COG3688	RNA-binding protein containing a PIN domain
NP437_00635	COG1595	DNA-templated transcription, initiation
NP437_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP437_00650	COG0250	Participates in transcription elongation, termination and antitermination
NP437_00660	COG0081	regulation of translation
NP437_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NP437_00675	COG2813	Specifically methylates the guanine in position
NP437_00680	COG0085	RNA polymerase activity
NP437_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NP437_00690	COG1358	cellular component organization or biogenesis
NP437_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NP437_00700	COG0049	tRNA binding
NP437_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP437_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NP437_00715	COG0596	Alpha beta hydrolase
NP437_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NP437_00730	COG0088	Forms part of the polypeptide exit tunnel
NP437_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NP437_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NP437_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NP437_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NP437_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NP437_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NP437_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NP437_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NP437_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NP437_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NP437_00820	COG0200	Binds to the 23S rRNA
NP437_00825	COG0201	protein transport
NP437_00830	COG0563	adenylate kinase activity
NP437_00835	COG0024	Methionine aminopeptidase
NP437_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
NP437_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NP437_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NP437_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NP437_00865	COG0202	RNA polymerase activity
NP437_00870	COG0203	ribosomal protein L17
NP437_00875	COG1122	ATPase activity
NP437_00880	COG1122	ATPase activity
NP437_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP437_00890	COG0101	tRNA pseudouridine synthase activity
NP437_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NP437_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NP437_00905	COG2226	methyltransferase
NP437_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP437_00920	COG0489	protein tyrosine kinase activity
NP437_00930	COG2194	sulfuric ester hydrolase activity
NP437_00935	COG0726	polysaccharide deacetylase
NP437_01020	COG0659	secondary active sulfate transmembrane transporter activity
NP437_01025	COG0385	Bile acid
NP437_01030	COG2819	hydrolase of the alpha beta superfamily
NP437_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP437_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP437_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP437_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP437_01050	COG2207	Transcriptional regulator
NP437_01055	COG3876	Protein conserved in bacteria
NP437_01060	COG1472	Belongs to the glycosyl hydrolase 3 family
NP437_01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP437_01070	COG1263	PTS System
NP437_01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_01075	COG1737	Transcriptional regulator
NP437_01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NP437_01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP437_01090	COG1683	Conserved Protein
NP437_01120	COG1595	DNA-templated transcription, initiation
NP437_01125	COG5662	AntiSigma factor
NP437_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP437_01135	COG4856	YbbR-like protein
NP437_01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP437_01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NP437_01160	COG2169	Transcriptional regulator
NP437_01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP437_01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP437_01175	COG3002	Belongs to the UPF0753 family
NP437_01180	COG0288	reversible hydration of carbon dioxide
NP437_01190	COG5609	conserved protein (DUF2294)
NP437_01200	COG0642	Histidine kinase
NP437_01210	COG0515	serine threonine protein kinase
NP437_01225	COG1113	amino acid transport
NP437_01240	COG2602	Beta-lactamase
NP437_01245	COG2124	cytochrome p450
NP437_01255	COG0531	amino acid
NP437_01260	COG0584	glycerophosphoryl diester phosphodiesterase
NP437_01265	COG2271	Major facilitator Superfamily
NP437_01275	COG0456	acetyltransferase
NP437_01275	COG1846	Transcriptional regulator
NP437_01290	COG3409	Peptidoglycan-binding domain 1 protein
NP437_01295	COG0697	spore germination
NP437_01300	COG1917	Cupin 2, conserved barrel domain protein
NP437_01300	COG2207	Transcriptional regulator
NP437_01325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NP437_01330	COG3591	Belongs to the peptidase S1B family
NP437_01340	COG0596	Alpha beta hydrolase
NP437_01345	COG1183	phosphatidylcholine synthase activity
NP437_01350	COG0586	Pfam SNARE associated Golgi protein
NP437_01355	COG0688	phosphatidylethanolamine metabolic process
NP437_01365	COG2312	Erythromycin esterase
NP437_01370	COG2207	Transcriptional regulator
NP437_01375	COG1054	Belongs to the UPF0176 family
NP437_01380	COG1301	dicarboxylic acid transport
NP437_01385	COG1263	PTS System
NP437_01385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_01385	COG2190	(PTS) system
NP437_01390	COG0363	glucosamine-6-phosphate deaminase activity
NP437_01395	COG2188	Transcriptional regulator
NP437_01405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP437_01410	COG0833	amino acid
NP437_01415	COG2040	homocysteine
NP437_01425	COG2066	Belongs to the glutaminase family
NP437_01430	COG4191	Histidine kinase
NP437_01435	COG0784	Response regulator, receiver
NP437_01440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP437_01445	COG1012	belongs to the aldehyde dehydrogenase family
NP437_01450	COG2271	Major facilitator Superfamily
NP437_01455	COG4948	Mandelate Racemase Muconate Lactonizing
NP437_01460	COG2186	Transcriptional regulator
NP437_01465	COG2721	sulfolactate sulfo-lyase activity
NP437_01470	COG3173	Aminoglycoside phosphotransferase
NP437_01480	COG0697	spore germination
NP437_01485	COG0745	RESPONSE REGULATOR receiver
NP437_01490	COG2205	protein histidine kinase activity
NP437_01495	COG1131	(ABC) transporter
NP437_01515	COG3773	Cell wall hydrolase
NP437_01520	COG2304	oxidoreductase activity
NP437_01530	COG3540	Alkaline phosphatase
NP437_01535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP437_01540	COG0805	protein transport
NP437_01545	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NP437_01550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP437_01555	COG0477	Major facilitator Superfamily
NP437_01560	COG1309	transcriptional regulator
NP437_01565	COG0252	asparaginase activity
NP437_01570	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NP437_01575	COG1714	RDD family
NP437_01580	COG1405	negative regulation of cell septum assembly
NP437_01580	COG3012	SEC-C Motif Domain Protein
NP437_01590	COG3279	Response regulator of the LytR AlgR family
NP437_01600	COG1668	transmembrane transport
NP437_01605	COG0667	Aldo Keto reductase
NP437_01620	COG1595	DNA-templated transcription, initiation
NP437_01625	COG1595	DNA-templated transcription, initiation
NP437_01630	COG1876	peptidase activity
NP437_01640	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_01645	COG0366	Alpha amylase catalytic
NP437_01650	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP437_01655	COG1121	(ABC) transporter
NP437_01660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP437_01670	COG2310	stress, protein
NP437_01675	COG2310	stress, protein
NP437_01680	COG2310	stress, protein
NP437_01685	COG0861	Integral membrane protein TerC family
NP437_01695	COG3853	Toxic anion resistance protein (TelA)
NP437_01705	COG0477	Major facilitator Superfamily
NP437_01710	COG2814	Major facilitator Superfamily
NP437_01715	COG0640	Transcriptional regulator
NP437_01720	COG0517	IMP dehydrogenase activity
NP437_01720	COG4175	Glycine betaine
NP437_01725	COG4176	ABC-type proline glycine betaine transport system permease component
NP437_01730	COG2113	Glycine betaine
NP437_01735	COG1473	amidohydrolase
NP437_01740	COG1288	antiporter activity
NP437_01755	COG0039	L-malate dehydrogenase activity
NP437_01770	COG3403	YqcI/YcgG family
NP437_01785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NP437_01790	COG1660	Displays ATPase and GTPase activities
NP437_01795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NP437_01805	COG2226	methyltransferase
NP437_01810	COG0583	DNA-binding transcription factor activity
NP437_01815	COG3458	cephalosporin-C deacetylase activity
NP437_01820	COG3541	Predicted nucleotidyltransferase
NP437_01825	COG0506	proline dehydrogenase activity
NP437_01830	COG1012	belongs to the aldehyde dehydrogenase family
NP437_01835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP437_01840	COG2508	Transcriptional regulator
NP437_01845	COG3689	TIGRFAM TIGR03943 family protein
NP437_01850	COG0701	Predicted permease
NP437_01855	COG2267	carboxylic ester hydrolase activity
NP437_01860	COG0492	ferredoxin-NADP+ reductase activity
NP437_01865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP437_01865	COG1587	Uroporphyrinogen-III synthase
NP437_01870	COG2146	nitrite reductase [NAD(P)H] activity
NP437_01875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP437_01880	COG0243	molybdopterin cofactor binding
NP437_01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP437_01890	COG2223	nitrite transmembrane transporter activity
NP437_01900	COG1376	ErfK ybiS ycfS ynhG family protein
NP437_01915	COG0765	amino acid transport
NP437_01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP437_01930	COG1714	RDD family
NP437_01940	COG1846	Transcriptional regulator
NP437_01955	COG2723	6-phospho-beta-galactosidase activity
NP437_01965	COG3209	COG3209 Rhs family protein
NP437_01975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NP437_01980	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NP437_01985	COG1733	regulation of RNA biosynthetic process
NP437_01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP437_02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP437_02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP437_02020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NP437_02025	COG2814	Major facilitator Superfamily
NP437_02035	COG0697	spore germination
NP437_02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP437_02050	COG2364	Membrane
NP437_02055	COG1126	abc transporter atp-binding protein
NP437_02060	COG0765	amino acid transport
NP437_02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP437_02070	COG0583	DNA-binding transcription factor activity
NP437_02075	COG0163	prenyltransferase activity
NP437_02080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NP437_02095	COG0596	Alpha beta hydrolase
NP437_02100	COG3104	oligopeptide transport
NP437_02105	COG5434	Belongs to the glycosyl hydrolase 28 family
NP437_02115	COG0697	spore germination
NP437_02125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NP437_02130	COG1136	(ABC) transporter
NP437_02135	COG0577	efflux transmembrane transporter activity
NP437_02140	COG0745	RESPONSE REGULATOR receiver
NP437_02145	COG3850	Histidine kinase
NP437_02145	COG5002	protein histidine kinase activity
NP437_02150	COG0457	Tetratricopeptide repeat
NP437_02170	COG0527	aspartate kinase activity
NP437_02175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP437_02180	COG4605	iron ion homeostasis
NP437_02185	COG4604	ABC transporter, ATP-binding protein
NP437_02190	COG4607	ABC-type enterochelin transport system periplasmic component
NP437_02200	COG2814	Major facilitator Superfamily
NP437_02205	COG1309	transcriptional regulator
NP437_02210	COG0778	Nitroreductase
NP437_02215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NP437_02220	COG0640	Transcriptional regulator
NP437_02225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP437_02230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP437_02235	COG1012	belongs to the aldehyde dehydrogenase family
NP437_02240	COG4975	Glucose uptake
NP437_02245	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_02250	COG4549	nuclear export factor GLE1
NP437_02255	COG1276	copper resistance
NP437_02255	COG2372	response to copper ion
NP437_02260	COG1349	DNA-binding transcription factor activity
NP437_02270	COG2213	PTS system mannitol-specific
NP437_02275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP437_02280	COG0246	Mannitol dehydrogenase
NP437_02285	COG0473	3-isopropylmalate dehydrogenase activity
NP437_02290	COG0681	Belongs to the peptidase S26 family
NP437_02300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP437_02310	COG0561	phosphatase activity
NP437_02315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NP437_02320	COG1914	H( )-stimulated, divalent metal cation uptake system
NP437_02325	COG4336	lyase activity
NP437_02330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NP437_02335	COG1984	allophanate hydrolase subunit 2
NP437_02340	COG1414	Transcriptional regulator
NP437_02345	COG2755	lipolytic protein G-D-S-L family
NP437_02355	COG2329	Antibiotic biosynthesis monooxygenase
NP437_02360	COG0768	penicillin binding
NP437_02365	COG4989	oxidoreductase activity
NP437_02370	COG3711	transcriptional antiterminator
NP437_02375	COG0318	PFAM AMP-dependent synthetase and ligase
NP437_02380	COG2226	methyltransferase
NP437_02385	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_02390	COG1917	Cupin 2, conserved barrel domain protein
NP437_02395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP437_02400	COG3871	stress protein (general stress protein 26)
NP437_02410	COG2814	Major facilitator Superfamily
NP437_02415	COG1522	sequence-specific DNA binding
NP437_02420	COG0551	DNA topoisomerase type I activity
NP437_02420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP437_02425	COG0494	nUDIX hydrolase
NP437_02430	COG0028	Belongs to the TPP enzyme family
NP437_02455	COG1914	H( )-stimulated, divalent metal cation uptake system
NP437_02460	COG2261	transglycosylase associated protein
NP437_02465	COG4876	unkown
NP437_02470	COG2217	Heavy metal translocating P-type atpase
NP437_02475	COG3729	General stress protein
NP437_02480	COG0662	Cupin 2, conserved barrel domain protein
NP437_02485	COG2329	Antibiotic biosynthesis monooxygenase
NP437_02490	COG3546	catalase activity
NP437_02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP437_02500	COG3290	protein histidine kinase activity
NP437_02505	COG4565	transcriptional regulatory protein
NP437_02510	COG1301	dicarboxylic acid transport
NP437_02515	COG0628	permease
NP437_02525	COG1131	(ABC) transporter
NP437_02530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP437_02540	COG1960	acyl-CoA dehydrogenase activity
NP437_02555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP437_02560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP437_02565	COG1181	Belongs to the D-alanine--D-alanine ligase family
NP437_02570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NP437_02575	COG0513	Belongs to the DEAD box helicase family
NP437_02580	COG3402	PFAM membrane-flanked domain
NP437_02585	COG3428	Bacterial PH domain
NP437_02590	COG0705	Rhomboid family
NP437_02595	COG0736	holo-[acyl-carrier-protein] synthase activity
NP437_02600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NP437_02605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP437_02610	COG0864	Transcriptional regulator
NP437_02615	COG2337	Toxic component of a toxin-antitoxin (TA) module
NP437_02620	COG1366	Belongs to the anti-sigma-factor antagonist family
NP437_02625	COG1366	Belongs to the anti-sigma-factor antagonist family
NP437_02630	COG2172	sigma factor antagonist activity
NP437_02635	COG2208	phosphoserine phosphatase activity
NP437_02640	COG1366	Belongs to the anti-sigma-factor antagonist family
NP437_02645	COG2172	sigma factor antagonist activity
NP437_02650	COG1191	sigma factor activity
NP437_02655	COG2208	phosphoserine phosphatase activity
NP437_02670	COG1673	EVE domain
NP437_02675	COG1846	Transcriptional regulator
NP437_02680	COG2183	response to ionizing radiation
NP437_02695	COG3091	SprT-like family
NP437_02735	COG0582	viral genome integration into host DNA
NP437_02740	COG2856	Zn peptidase
NP437_02745	COG1396	sequence-specific DNA binding
NP437_02775	COG1674	ftsk spoiiie
NP437_02780	COG2946	Replication initiation factor
NP437_02820	COG0433	COG0433 Predicted ATPase
NP437_02830	COG5644	endopeptidase inhibitor activity
NP437_02840	COG0741	lytic transglycosylase activity
NP437_02840	COG0791	NLP P60 protein
NP437_02855	COG0457	Tetratricopeptide repeat
NP437_02895	COG0583	DNA-binding transcription factor activity
NP437_02900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP437_02910	COG5444	nuclease activity
NP437_02915	COG1476	TRANSCRIPTIONal
NP437_02940	COG0693	protein deglycase activity
NP437_02945	COG1278	Cold shock
NP437_02950	COG1329	Transcriptional regulator
NP437_02955	COG0697	spore germination
NP437_02960	COG1917	Cupin 2, conserved barrel domain protein
NP437_02960	COG2207	Transcriptional regulator
NP437_02970	COG2207	Transcriptional regulator
NP437_02970	COG3708	Transcriptional regulator
NP437_02975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP437_02990	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
NP437_03005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP437_03010	COG1309	transcriptional regulator
NP437_03015	COG0697	spore germination
NP437_03020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP437_03025	COG2030	dehydratase
NP437_03030	COG3545	Serine hydrolase
NP437_03040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP437_03045	COG0640	Transcriptional regulator
NP437_03050	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP437_03060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP437_03065	COG0697	spore germination
NP437_03070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP437_03075	COG0076	glutamate decarboxylase activity
NP437_03080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP437_03085	COG0640	Transcriptional regulator
NP437_03090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NP437_03105	COG4585	Histidine kinase
NP437_03110	COG2197	response regulator
NP437_03115	COG2409	Drug exporters of the RND superfamily
NP437_03120	COG0596	Alpha beta hydrolase
NP437_03125	COG1811	Na channel or pump
NP437_03130	COG4978	Transcriptional regulator
NP437_03130	COG0789	Transcriptional regulator
NP437_03135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP437_03140	COG0778	Nitroreductase
NP437_03145	COG0346	lactoylglutathione lyase activity
NP437_03150	COG2259	Doxx family
NP437_03155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP437_03185	COG2323	membrane
NP437_03190	COG0071	Belongs to the small heat shock protein (HSP20) family
NP437_03205	COG1309	transcriptional regulator
NP437_03215	COG0456	acetyltransferase
NP437_03220	COG0488	(ABC) transporter
NP437_03225	COG1113	amino acid transport
NP437_03230	COG2318	DinB family
NP437_03235	COG1846	Transcriptional regulator
NP437_03240	COG2409	Drug exporters of the RND superfamily
NP437_03240	COG1033	growth of symbiont in host cell
NP437_03245	COG0778	Nitroreductase
NP437_03250	COG1846	Transcriptional regulator
NP437_03255	COG2814	Major facilitator Superfamily
NP437_03260	COG0730	response to heat
NP437_03265	COG1802	Transcriptional regulator
NP437_03270	COG1388	LysM domain
NP437_03270	COG3858	chitin binding
NP437_03275	COG1819	glycosyl
NP437_03285	COG1785	Belongs to the alkaline phosphatase family
NP437_03290	COG5646	InterPro IPR014922
NP437_03300	COG0454	-acetyltransferase
NP437_03305	COG1078	dGTPase activity
NP437_03310	COG1388	LysM domain
NP437_03315	COG2814	Major facilitator Superfamily
NP437_03320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP437_03335	COG2723	6-phospho-beta-galactosidase activity
NP437_03340	COG2188	Transcriptional regulator
NP437_03345	COG1940	carbohydrate kinase activity
NP437_03355	COG4124	Belongs to the glycosyl hydrolase 26 family
NP437_03400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NP437_03405	COG0802	atpase or kinase
NP437_03410	COG1214	PFAM Peptidase M22, glycoprotease
NP437_03415	COG0456	acetyltransferase
NP437_03420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NP437_03425	COG0488	(ABC) transporter
NP437_03430	COG0315	cyclic pyranopterin monophosphate synthase activity
NP437_03435	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NP437_03440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP437_03445	COG0805	protein transport
NP437_03455	COG1266	CAAX protease self-immunity
NP437_03465	COG0459	protein refolding
NP437_03480	COG0457	Tetratricopeptide repeat
NP437_03485	COG1063	alcohol dehydrogenase
NP437_03490	COG2211	Major facilitator Superfamily
NP437_03495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP437_03505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP437_03510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NP437_03515	COG4260	virion core protein, lumpy skin disease virus
NP437_03525	COG2814	Major facilitator Superfamily
NP437_03530	COG1063	alcohol dehydrogenase
NP437_03535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NP437_03540	COG0823	Involved in the tonB-independent uptake of proteins
NP437_03560	COG2267	carboxylic ester hydrolase activity
NP437_03570	COG2132	Multicopper oxidase
NP437_03575	COG1113	amino acid transport
NP437_03585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP437_03590	COG0714	Associated with various cellular activities
NP437_03595	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NP437_03600	COG1305	Transglutaminase-like
NP437_03605	COG0519	Catalyzes the synthesis of GMP from XMP
NP437_03605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NP437_03615	COG2252	PERMEase
NP437_03620	COG3064	Membrane
NP437_03630	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
NP437_03640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NP437_03645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NP437_03650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NP437_03655	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NP437_03660	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP437_03665	COG0047	phosphoribosylformylglycinamidine synthase activity
NP437_03670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP437_03675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NP437_03680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NP437_03685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NP437_03690	COG0138	bifunctional purine biosynthesis protein purh
NP437_03695	COG0151	Belongs to the GarS family
NP437_03700	COG1522	sequence-specific DNA binding
NP437_03705	COG0531	amino acid
NP437_03715	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP437_03720	COG1470	cell adhesion involved in biofilm formation
NP437_03725	COG4496	protein, YerC YecD
NP437_03730	COG0069	glutamate synthase activity
NP437_03735	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NP437_03740	COG0210	DNA helicase
NP437_03745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NP437_03750	COG4851	CamS sex pheromone cAM373 precursor
NP437_03760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP437_03765	COG1285	pathogenesis
NP437_03770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP437_03775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP437_03780	COG0154	amidase activity
NP437_03785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP437_03795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP437_03800	COG1597	lipid kinase activity
NP437_03805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP437_03810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP437_03835	COG5444	nuclease activity
NP437_03845	COG0457	Tetratricopeptide repeat
NP437_03855	COG0217	transcriptional regulatory protein
NP437_03865	COG1309	transcriptional regulator
NP437_03880	COG3546	catalase activity
NP437_03885	COG0454	-acetyltransferase
NP437_03895	COG5578	integral membrane protein
NP437_03900	COG2972	Histidine kinase
NP437_03910	COG1653	transport
NP437_03915	COG1175	transmembrane transport
NP437_03920	COG0395	ABC-type sugar transport system, permease component
NP437_03925	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NP437_03930	COG2207	Transcriptional regulator
NP437_03935	COG2755	lipolytic protein G-D-S-L family
NP437_03945	COG5578	integral membrane protein
NP437_03950	COG3401	FG-GAP repeat protein
NP437_03955	COG3401	FG-GAP repeat protein
NP437_03960	COG2755	lipolytic protein G-D-S-L family
NP437_03975	COG1653	transport
NP437_03980	COG4209	transmembrane transport
NP437_03985	COG0395	ABC-type sugar transport system, permease component
NP437_03990	COG1486	melibiose metabolic process
NP437_04000	COG2323	membrane
NP437_04005	COG2329	Antibiotic biosynthesis monooxygenase
NP437_04010	COG0346	lactoylglutathione lyase activity
NP437_04025	COG5583	Uncharacterized small protein (DUF2292)
NP437_04030	COG0670	Belongs to the BI1 family
NP437_04045	COG3328	transposase activity
NP437_04055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP437_04055	COG2124	cytochrome p450
NP437_04060	COG1368	sulfuric ester hydrolase activity
NP437_04065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NP437_04070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP437_04075	COG1442	glycosyl transferase family 8
NP437_04080	COG1216	Glycosyl transferase, family 2
NP437_04085	COG1442	glycosyl transferase family 8
NP437_04090	COG2223	nitrite transmembrane transporter activity
NP437_04095	COG1011	Hydrolase
NP437_04100	COG0531	amino acid
NP437_04105	COG1012	belongs to the aldehyde dehydrogenase family
NP437_04110	COG0840	transmembrane signaling receptor activity
NP437_04115	COG0488	(ABC) transporter
NP437_04125	COG0789	Transcriptional regulator
NP437_04130	COG2814	Major facilitator Superfamily
NP437_04150	COG0488	(ABC) transporter
NP437_04155	COG0513	Belongs to the DEAD box helicase family
NP437_04165	COG3866	Pectate lyase
NP437_04170	COG0471	metal ion transport
NP437_04175	COG3290	protein histidine kinase activity
NP437_04180	COG4565	transcriptional regulatory protein
NP437_04185	COG3181	Tripartite tricarboxylate transporter family receptor
NP437_04195	COG2851	Citrate transporter
NP437_04200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP437_04205	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NP437_04210	COG1254	Belongs to the acylphosphatase family
NP437_04215	COG2258	MOSC domain
NP437_04235	COG0024	Methionine aminopeptidase
NP437_04240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_04240	COG1263	PTS System
NP437_04245	COG1368	sulfuric ester hydrolase activity
NP437_04260	COG1115	amino acid carrier protein
NP437_04275	COG1263	PTS System
NP437_04275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_04280	COG0366	Alpha amylase catalytic
NP437_04285	COG2188	Transcriptional regulator
NP437_04290	COG0778	Nitroreductase
NP437_04295	COG0737	Belongs to the 5'-nucleotidase family
NP437_04300	COG0693	protein deglycase activity
NP437_04310	COG2814	Major facilitator Superfamily
NP437_04315	COG4840	Belongs to the UPF0435 family
NP437_04320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP437_04325	COG4980	gas vesicle protein
NP437_04330	COG1295	ribonuclease BN
NP437_04340	COG0477	Major facilitator Superfamily
NP437_04345	COG0387	Pfam Sodium calcium exchanger
NP437_04355	COG0668	transmembrane transport
NP437_04360	COG0535	radical SAM domain protein
NP437_04370	COG0726	polysaccharide deacetylase
NP437_04375	COG2084	Dehydrogenase
NP437_04380	COG0598	Magnesium transport protein CorA
NP437_04385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NP437_04390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP437_04400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP437_04405	COG4637	Psort location Cytoplasmic, score
NP437_04415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP437_04420	COG0022	dehydrogenase e1 component
NP437_04425	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP437_04430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP437_04435	COG3284	Transcriptional regulator
NP437_04445	COG1742	UPF0060 membrane protein
NP437_04470	COG4842	Belongs to the WXG100 family
NP437_04475	COG1486	melibiose metabolic process
NP437_04480	COG1737	Transcriptional regulator
NP437_04485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_04485	COG1263	PTS System
NP437_04490	COG5434	Belongs to the glycosyl hydrolase 28 family
NP437_04495	COG1132	(ABC) transporter
NP437_04500	COG1132	(ABC) transporter
NP437_04505	COG2259	Doxx family
NP437_04510	COG2514	catechol 2,3-dioxygenase activity
NP437_04515	COG1917	Cupin 2, conserved barrel domain protein
NP437_04515	COG4977	sequence-specific DNA binding
NP437_04520	COG2814	Major facilitator Superfamily
NP437_04525	COG1082	Xylose isomerase domain protein TIM barrel
NP437_04535	COG4585	Histidine kinase
NP437_04540	COG2197	response regulator
NP437_04545	COG1131	(ABC) transporter
NP437_04550	COG0842	Transport permease protein
NP437_04550	COG1511	domain protein
NP437_04555	COG0842	Transport permease protein
NP437_04560	COG1695	Transcriptional regulator
NP437_04565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NP437_04570	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
NP437_04575	COG1309	transcriptional regulator
NP437_04580	COG2814	Major facilitator Superfamily
NP437_04585	COG2318	DinB family
NP437_04595	COG1846	Transcriptional regulator
NP437_04600	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NP437_04600	COG0392	lysyltransferase activity
NP437_04605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP437_04610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP437_04615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP437_04620	COG0384	phenazine biosynthesis protein PhzF
NP437_04625	COG0778	Nitroreductase
NP437_04640	COG1090	epimerase
NP437_04645	COG2137	regulation of response to DNA damage stimulus
NP437_04655	COG2814	Major facilitator Superfamily
NP437_04670	COG3103	Sh3 type 3 domain protein
NP437_04675	COG5658	integral membrane protein
NP437_04680	COG0596	Alpha beta hydrolase
NP437_04685	COG0463	Glycosyl transferase, family 2
NP437_04690	COG4485	Bacterial membrane protein, YfhO
NP437_04695	COG1988	membrane-bound metal-dependent
NP437_04700	COG1194	a g-specific adenine glycosylase
NP437_04710	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_04725	COG3557	Belongs to the UPF0374 family
NP437_04730	COG1132	(ABC) transporter
NP437_04735	COG4129	membrane
NP437_04740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP437_04745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NP437_04750	COG0735	belongs to the Fur family
NP437_04860	COG4326	sporulation control protein
NP437_04870	COG5577	PFAM Coat F domain
NP437_04875	COG3340	Belongs to the peptidase S51 family
NP437_04880	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NP437_04895	COG0753	catalase activity
NP437_04900	COG1116	anion transmembrane transporter activity
NP437_04905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP437_04910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP437_04915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP437_04925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NP437_04935	COG1476	TRANSCRIPTIONal
NP437_04945	COG3382	B3 4 domain protein
NP437_04950	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NP437_04960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NP437_04965	COG0789	Transcriptional regulator
NP437_04970	COG1664	Polymer-forming cytoskeletal
NP437_04975	COG1664	Polymer-forming cytoskeletal
NP437_04980	COG2766	serine protein kinase
NP437_04985	COG2718	Belongs to the UPF0229 family
NP437_04990	COG1846	Transcriptional regulator
NP437_04995	COG1566	PFAM secretion protein HlyD family protein
NP437_05000	COG2814	Major facilitator Superfamily
NP437_05005	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP437_05025	COG1725	Transcriptional regulator
NP437_05030	COG1131	(ABC) transporter
NP437_05035	COG1131	(ABC) transporter
NP437_05040	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP437_05045	COG1278	Cold shock
NP437_05050	COG1464	Belongs to the NlpA lipoprotein family
NP437_05055	COG3706	GGDEF domain
NP437_05060	COG1823	symporter activity
NP437_05065	COG5444	nuclease activity
NP437_05090	COG0582	viral genome integration into host DNA
NP437_05155	COG5644	endopeptidase inhibitor activity
NP437_05160	COG0741	lytic transglycosylase activity
NP437_05160	COG0791	NLP P60 protein
NP437_05180	COG0457	Tetratricopeptide repeat
NP437_05200	COG0737	Belongs to the 5'-nucleotidase family
NP437_05200	COG1525	nuclease
NP437_05200	COG4085	toxin activity
NP437_05205	COG3764	Sortase (surface protein transpeptidase)
NP437_05210	COG0564	pseudouridine synthase activity
NP437_05220	COG0517	IMP dehydrogenase activity
NP437_05225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP437_05230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP437_05230	COG3153	acetyltransferase
NP437_05235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP437_05240	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NP437_05245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NP437_05250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NP437_05255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NP437_05260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP437_05265	COG4585	Histidine kinase
NP437_05265	COG2203	Gaf domain
NP437_05270	COG2197	response regulator
NP437_05275	COG0431	NADPH-dependent FMN reductase
NP437_05290	COG1388	LysM domain
NP437_05290	COG0791	NLP P60 protein
NP437_05295	COG1959	2 iron, 2 sulfur cluster binding
NP437_05300	COG0668	transmembrane transport
NP437_05305	COG2719	SpoVR family
NP437_05315	COG1785	Belongs to the alkaline phosphatase family
NP437_05320	COG1388	LysM domain
NP437_05320	COG0791	NLP P60 protein
NP437_05325	COG0583	DNA-binding transcription factor activity
NP437_05330	COG0372	Belongs to the citrate synthase family
NP437_05335	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_05340	COG0531	amino acid
NP437_05345	COG0733	neurotransmitter:sodium symporter activity
NP437_05350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP437_05355	COG0456	acetyltransferase
NP437_05370	COG1595	DNA-templated transcription, initiation
NP437_05375	COG0667	Aldo Keto reductase
NP437_05380	COG0204	Acyl-transferase
NP437_05385	COG1253	flavin adenine dinucleotide binding
NP437_05390	COG0789	Transcriptional regulator
NP437_05400	COG1253	flavin adenine dinucleotide binding
NP437_05405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP437_05410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP437_05415	COG0584	glycerophosphoryl diester phosphodiesterase
NP437_05425	COG0668	transmembrane transport
NP437_05430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NP437_05435	COG0726	polysaccharide deacetylase
NP437_05440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP437_05445	COG1757	Na H antiporter
NP437_05450	COG0589	response to stress
NP437_05460	COG1132	(ABC) transporter
NP437_05465	COG1132	(ABC) transporter
NP437_05470	COG0702	epimerase
NP437_05495	COG0189	ligase activity
NP437_05500	COG0189	ligase activity
NP437_05505	COG4399	Belongs to the UPF0754 family
NP437_05510	COG3679	Belongs to the UPF0342 family
NP437_05520	COG0561	phosphatase activity
NP437_05525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP437_05530	COG0475	glutathione-regulated potassium exporter activity
NP437_05535	COG0490	domain, Protein
NP437_05545	COG1024	Enoyl-CoA hydratase
NP437_05555	COG4152	abc transporter atp-binding protein
NP437_05560	COG1668	transmembrane transport
NP437_05565	COG0420	3'-5' exonuclease activity
NP437_05570	COG4717	serine-type aminopeptidase activity
NP437_05575	COG3481	metal-dependent phosphohydrolase, HD sub domain
NP437_05585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP437_05615	COG1846	Transcriptional regulator
NP437_05620	COG4980	gas vesicle protein
NP437_05635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NP437_05640	COG0537	adenosine 5'-monophosphoramidase activity
NP437_05645	COG1131	(ABC) transporter
NP437_05650	COG4473	ABC transporter
NP437_05660	COG1473	amidohydrolase
NP437_05665	COG3069	C4-dicarboxylate transmembrane transporter activity
NP437_05675	COG2329	Antibiotic biosynthesis monooxygenase
NP437_05680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP437_05685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NP437_05690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NP437_05695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NP437_05700	COG1309	transcriptional regulator
NP437_05705	COG1511	domain protein
NP437_05710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP437_05715	COG4377	Putative membrane peptidase family (DUF2324)
NP437_05725	COG1363	Peptidase, m42
NP437_05730	COG4405	Protein conserved in bacteria
NP437_05735	COG1301	dicarboxylic acid transport
NP437_05745	COG1234	tRNA 3'-trailer cleavage
NP437_05750	COG0095	Lipoate-protein ligase
NP437_05755	COG0702	epimerase
NP437_05760	COG0318	PFAM AMP-dependent synthetase and ligase
NP437_05770	COG0501	Belongs to the peptidase M48B family
NP437_05780	COG0456	acetyltransferase
NP437_05785	COG0604	alcohol dehydrogenase
NP437_05790	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP437_05795	COG0406	alpha-ribazole phosphatase activity
NP437_05800	COG0183	Belongs to the thiolase family
NP437_05805	COG0318	PFAM AMP-dependent synthetase and ligase
NP437_05810	COG1268	BioY protein
NP437_05815	COG0840	transmembrane signaling receptor activity
NP437_05825	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_05835	COG4903	ComK protein
NP437_05840	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_05850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP437_05865	COG0398	Pfam SNARE associated Golgi protein
NP437_05870	COG0681	Belongs to the peptidase S26 family
NP437_05875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP437_05880	COG1846	Transcriptional regulator
NP437_05890	COG0738	Major facilitator superfamily
NP437_05895	COG0673	inositol 2-dehydrogenase activity
NP437_05900	COG0561	phosphatase activity
NP437_05905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP437_05910	COG1609	Transcriptional regulator
NP437_05915	COG3180	Ammonia monooxygenase
NP437_05920	COG2814	Major facilitator Superfamily
NP437_05920	COG0477	Major facilitator Superfamily
NP437_05925	COG4533	DNA binding
NP437_05945	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NP437_05950	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NP437_05955	COG1074	ATP-dependent DNA helicase activity
NP437_05960	COG0420	3'-5' exonuclease activity
NP437_05965	COG0419	ATPase involved in DNA repair
NP437_05970	COG1403	HNH endonuclease
NP437_06010	COG5337	Spore coat protein CotH
NP437_06015	COG0179	Fumarylacetoacetate (FAA) hydrolase
NP437_06025	COG1404	Belongs to the peptidase S8 family
NP437_06045	COG0367	asparagine synthase
NP437_06055	COG0534	Mate efflux family protein
NP437_06060	COG1917	Cupin 2, conserved barrel domain protein
NP437_06060	COG2207	Transcriptional regulator
NP437_06065	COG1609	Transcriptional regulator
NP437_06070	COG0673	inositol 2-dehydrogenase activity
NP437_06075	COG2318	DinB family
NP437_06080	COG1279	arginine transmembrane transporter activity
NP437_06085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP437_06090	COG1357	PFAM Pentapeptide repeats (8 copies)
NP437_06095	COG2267	carboxylic ester hydrolase activity
NP437_06105	COG2153	protein acetylation
NP437_06110	COG0646	methionine synthase
NP437_06110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NP437_06115	COG1666	GTP binding
NP437_06130	COG1307	EDD domain protein, DegV family
NP437_06135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP437_06155	COG0561	phosphatase activity
NP437_06160	COG1073	alpha beta
NP437_06165	COG2151	metal-sulfur cluster biosynthetic enzyme
NP437_06175	COG0277	FAD linked oxidase domain protein
NP437_06185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NP437_06190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NP437_06200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP437_06205	COG0505	Belongs to the CarA family
NP437_06210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP437_06215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NP437_06235	COG2267	carboxylic ester hydrolase activity
NP437_06245	COG1744	ABC transporter substrate-binding protein PnrA-like
NP437_06260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP437_06265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP437_06270	COG5504	Zn-dependent protease
NP437_06275	COG0444	Belongs to the ABC transporter superfamily
NP437_06280	COG4608	Belongs to the ABC transporter superfamily
NP437_06290	COG0601	transmembrane transport
NP437_06295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP437_06305	COG0180	Tryptophanyl-tRNA synthetase
NP437_06310	COG4166	transmembrane transport
NP437_06315	COG0601	transmembrane transport
NP437_06320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP437_06325	COG0444	Belongs to the ABC transporter superfamily
NP437_06330	COG4608	Belongs to the ABC transporter superfamily
NP437_06335	COG2814	Major facilitator Superfamily
NP437_06340	COG0456	acetyltransferase
NP437_06345	COG1393	Belongs to the ArsC family
NP437_06350	COG0861	Integral membrane protein TerC family
NP437_06360	COG4862	establishment of competence for transformation
NP437_06370	COG4469	Competence protein
NP437_06375	COG1164	Oligoendopeptidase f
NP437_06385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP437_06390	COG2346	COG2346, Truncated hemoglobins
NP437_06395	COG0741	lytic transglycosylase activity
NP437_06400	COG4116	CYTH
NP437_06410	COG2357	RelA SpoT domain protein
NP437_06415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP437_06420	COG0564	pseudouridine synthase activity
NP437_06425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NP437_06430	COG0569	domain protein
NP437_06430	COG0475	glutathione-regulated potassium exporter activity
NP437_06435	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NP437_06440	COG0352	thiamine-phosphate diphosphorylase activity
NP437_06445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP437_06450	COG2104	thiamine diphosphate biosynthetic process
NP437_06455	COG2022	thiamine diphosphate biosynthetic process
NP437_06460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP437_06465	COG0351	phosphomethylpyrimidine kinase
NP437_06470	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NP437_06525	COG0210	DNA helicase
NP437_06535	COG2153	protein acetylation
NP437_06540	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP437_06545	COG2382	esterase
NP437_06550	COG0626	cystathionine gamma-synthase activity
NP437_06555	COG0626	cystathionine gamma-synthase activity
NP437_06560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP437_06565	COG5505	Protein of unknown function (DUF819)
NP437_06605	COG1396	sequence-specific DNA binding
NP437_06690	COG0457	Tetratricopeptide repeat
NP437_06695	COG5444	nuclease activity
NP437_06705	COG3328	transposase activity
NP437_06765	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NP437_06775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP437_06775	COG3711	transcriptional antiterminator
NP437_06780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP437_06780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP437_06780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP437_06785	COG1482	cell wall glycoprotein biosynthetic process
NP437_06800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP437_06810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NP437_06825	COG0109	protoheme IX farnesyltransferase activity
NP437_06835	COG0726	polysaccharide deacetylase
NP437_06850	COG5504	Zn-dependent protease
NP437_06855	COG2205	protein histidine kinase activity
NP437_06870	COG2427	Protein of unknown function (DUF1641)
NP437_06880	COG1051	belongs to the nudix hydrolase family
NP437_06890	COG2124	cytochrome p450
NP437_06895	COG1819	glycosyl
NP437_06905	COG1587	Uroporphyrinogen-III synthase
NP437_06910	COG0390	transport system, permease component
NP437_06915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP437_06920	COG0697	spore germination
NP437_06935	COG1252	NADH dehydrogenase
NP437_06940	COG1904	glucuronate isomerase
NP437_06945	COG2211	Major facilitator Superfamily
NP437_06950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NP437_06955	COG1063	alcohol dehydrogenase
NP437_06960	COG1312	Catalyzes the dehydration of D-mannonate
NP437_06965	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_06970	COG2271	Major facilitator Superfamily
NP437_06975	COG1609	Transcriptional regulator
NP437_06980	COG0246	Mannitol dehydrogenase
NP437_06985	COG2721	sulfolactate sulfo-lyase activity
NP437_06990	COG0730	response to heat
NP437_06995	COG2318	DinB family
NP437_07015	COG0457	Tetratricopeptide repeat
NP437_07030	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP437_07030	COG3409	Peptidoglycan-binding domain 1 protein
NP437_07030	COG1388	LysM domain
NP437_07040	COG4195	phage-related replication protein
NP437_07045	COG3546	catalase activity
NP437_07050	COG2856	Zn peptidase
NP437_07055	COG1396	sequence-specific DNA binding
NP437_07065	COG1522	sequence-specific DNA binding
NP437_07070	COG1484	DNA-dependent DNA replication
NP437_07090	COG1595	DNA-templated transcription, initiation
NP437_07095	COG5484	DNA packaging
NP437_07095	COG3728	DNA packaging
NP437_07100	COG1783	phage Terminase large subunit
NP437_07105	COG5518	Phage portal protein
NP437_07110	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NP437_07115	COG4653	Phage capsid family
NP437_07165	COG3953	SLT domain
NP437_07165	COG5412	phage tail tape measure protein
NP437_07165	COG5412	phage tail tape measure protein
NP437_07165	COG3953	SLT domain
NP437_07165	COG5412	phage tail tape measure protein
NP437_07165	COG3953	SLT domain
NP437_07170	COG1652	LysM domain
NP437_07175	COG4193	domain, Protein
NP437_07185	COG3628	GPW Gp25 family protein
NP437_07190	COG3299	homolog of phage Mu protein gp47
NP437_07195	COG3778	Protein conserved in bacteria
NP437_07235	COG3409	Peptidoglycan-binding domain 1 protein
NP437_07235	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP437_07255	COG0306	phosphate transporter
NP437_07260	COG1392	Phosphate transport regulator
NP437_07265	COG0531	amino acid
NP437_07270	COG0346	lactoylglutathione lyase activity
NP437_07280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP437_07285	COG0463	Glycosyl transferase, family 2
NP437_07290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP437_07295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP437_07300	COG2362	D-Aminopeptidase
NP437_07305	COG0601	transmembrane transport
NP437_07310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP437_07315	COG0444	Belongs to the ABC transporter superfamily
NP437_07320	COG4166	transmembrane transport
NP437_07325	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP437_07330	COG4948	Mandelate Racemase Muconate Lactonizing
NP437_07335	COG0791	NLP P60 protein
NP437_07340	COG4608	Belongs to the ABC transporter superfamily
NP437_07345	COG2706	6-phosphogluconolactonase activity
NP437_07355	COG1607	acyl-coa hydrolase
NP437_07360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP437_07360	COG1017	nitric oxide dioxygenase activity
NP437_07370	COG2323	membrane
NP437_07375	COG2318	DinB family
NP437_07380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP437_07385	COG2076	Multidrug Resistance protein
NP437_07390	COG2076	Multidrug Resistance protein
NP437_07395	COG0788	formyltetrahydrofolate deformylase activity
NP437_07400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP437_07405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NP437_07410	COG1764	response to oxidative stress
NP437_07415	COG1846	Transcriptional regulator
NP437_07420	COG1764	response to oxidative stress
NP437_07430	COG0590	tRNA wobble adenosine to inosine editing
NP437_07435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP437_07440	COG1404	Belongs to the peptidase S8 family
NP437_07445	COG1366	Belongs to the anti-sigma-factor antagonist family
NP437_07450	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP437_07455	COG1122	ATPase activity
NP437_07460	COG4721	ABC-type cobalt transport system, permease component
NP437_07470	COG0745	RESPONSE REGULATOR receiver
NP437_07475	COG5002	protein histidine kinase activity
NP437_07475	COG3850	Histidine kinase
NP437_07480	COG3212	peptidase
NP437_07485	COG3212	peptidase
NP437_07500	COG2239	Acts as a magnesium transporter
NP437_07505	COG0789	Transcriptional regulator
NP437_07520	COG1846	Transcriptional regulator
NP437_07525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP437_07530	COG0726	polysaccharide deacetylase
NP437_07535	COG1408	metallophosphoesterase
NP437_07545	COG0463	Glycosyl transferase, family 2
NP437_07550	COG1793	dna ligase
NP437_07550	COG3285	dna ligase
NP437_07555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NP437_07560	COG5001	Diguanylate cyclase
NP437_07560	COG3300	MHYT domain
NP437_07565	COG0586	Pfam SNARE associated Golgi protein
NP437_07570	COG0861	Integral membrane protein TerC family
NP437_07575	COG1191	sigma factor activity
NP437_07595	COG0501	Belongs to the peptidase M48B family
NP437_07600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP437_07615	COG3594	Acyltransferase
NP437_07620	COG5002	protein histidine kinase activity
NP437_07625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP437_07635	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NP437_07640	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NP437_07645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP437_07650	COG0436	Aminotransferase
NP437_07655	COG1850	ribulose-bisphosphate carboxylase activity
NP437_07660	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NP437_07665	COG0235	Class ii aldolase
NP437_07670	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NP437_07675	COG3339	Conserved Protein
NP437_07690	COG3852	Histidine kinase
NP437_07695	COG1846	Transcriptional regulator
NP437_07700	COG1360	Flagellar Motor Protein
NP437_07705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP437_07710	COG0542	response to heat
NP437_07715	COG3949	Membrane
NP437_07720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NP437_07725	COG0720	synthase
NP437_07730	COG0602	queuosine metabolic process
NP437_07735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NP437_07745	COG4873	Protein conserved in bacteria
NP437_07755	COG3773	Cell wall hydrolase
NP437_07760	COG2244	polysaccharide biosynthetic process
NP437_07765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP437_07770	COG2217	Heavy metal translocating P-type atpase
NP437_07780	COG0006	proline dipeptidase activity
NP437_07785	COG1609	Transcriptional regulator
NP437_07790	COG3711	transcriptional antiterminator
NP437_07795	COG2190	(PTS) system
NP437_07795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_07795	COG1263	PTS System
NP437_07800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP437_07805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP437_07815	COG1533	DNA photolyase activity
NP437_07820	COG0456	acetyltransferase
NP437_07825	COG0840	transmembrane signaling receptor activity
NP437_07830	COG2084	Dehydrogenase
NP437_07840	COG3328	transposase activity
NP437_07850	COG0768	penicillin binding
NP437_07855	COG4191	Histidine kinase
NP437_07860	COG0436	Aminotransferase
NP437_07870	COG0835	chemotaxis
NP437_07870	COG0784	Response regulator, receiver
NP437_07880	COG2814	Major facilitator Superfamily
NP437_07885	COG1376	ErfK ybiS ycfS ynhG family protein
NP437_07890	COG1408	metallophosphoesterase
NP437_07895	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_07900	COG2200	EAL domain
NP437_07905	COG4703	Protein of unknown function (DUF1797)
NP437_07910	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NP437_07920	COG0517	IMP dehydrogenase activity
NP437_07925	COG0583	DNA-binding transcription factor activity
NP437_07930	COG0716	FMN binding
NP437_07940	COG0716	FMN binding
NP437_07945	COG2171	N-acyltransferase activity
NP437_07950	COG1473	amidohydrolase
NP437_07960	COG0668	transmembrane transport
NP437_07965	COG0450	alkyl hydroperoxide reductase
NP437_07970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP437_07990	COG0746	molybdenum cofactor guanylyltransferase activity
NP437_07995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP437_08000	COG0303	'Molybdopterin
NP437_08005	COG1763	Mo-molybdopterin cofactor biosynthetic process
NP437_08010	COG0314	molybdopterin synthase activity
NP437_08015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NP437_08025	COG1132	(ABC) transporter
NP437_08035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP437_08040	COG1136	(ABC) transporter
NP437_08045	COG0577	efflux transmembrane transporter activity
NP437_08050	COG1349	DNA-binding transcription factor activity
NP437_08055	COG1105	Belongs to the carbohydrate kinase PfkB family
NP437_08060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP437_08060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP437_08060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP437_08065	COG0681	Belongs to the peptidase S26 family
NP437_08075	COG0488	(ABC) transporter
NP437_08080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP437_08085	COG2309	aminopeptidase activity
NP437_08095	COG1077	Cell shape determining protein MreB Mrl
NP437_08100	COG2002	toxin-antitoxin pair type II binding
NP437_08105	COG3852	Histidine kinase
NP437_08110	COG2105	PFAM AIG2 family protein
NP437_08110	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NP437_08115	COG0569	domain protein
NP437_08120	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP437_08125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP437_08130	COG5503	Protein of unknown function (DUF1447)
NP437_08135	COG0561	phosphatase activity
NP437_08140	COG0242	peptide deformylase activity
NP437_08155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP437_08160	COG0022	dehydrogenase e1 component
NP437_08165	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP437_08170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP437_08175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP437_08185	COG1982	Orn Lys Arg decarboxylase major
NP437_08190	COG4476	Belongs to the UPF0223 family
NP437_08195	COG4493	Belongs to the UPF0637 family
NP437_08205	COG0483	inositol monophosphate 1-phosphatase activity
NP437_08220	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NP437_08260	COG1217	gtp-binding protein TYPA
NP437_08270	COG4896	Protein conserved in bacteria
NP437_08280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NP437_08285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP437_08290	COG2066	Belongs to the glutaminase family
NP437_08295	COG4838	Belongs to the UPF0358 family
NP437_08300	COG0772	Belongs to the SEDS family
NP437_08305	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NP437_08310	COG1612	heme a metabolic process
NP437_08315	COG0109	protoheme IX farnesyltransferase activity
NP437_08320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP437_08320	COG2010	Cytochrome c
NP437_08325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP437_08330	COG1845	cytochrome c oxidase, subunit III
NP437_08335	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP437_08340	COG3336	cytochrome c oxidase
NP437_08350	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NP437_08355	COG2340	Cysteine-rich secretory protein family
NP437_08370	COG3679	Belongs to the UPF0342 family
NP437_08375	COG4471	UPF0298 protein
NP437_08380	COG0742	ribosomal rna small subunit methyltransferase
NP437_08385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NP437_08390	COG3314	Sporulation integral membrane protein YlbJ
NP437_08395	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP437_08400	COG3480	Lon protease (S16) C-terminal proteolytic domain
NP437_08405	COG1323	Belongs to the UPF0348 family
NP437_08415	COG1399	metal-binding, possibly nucleic acid-binding protein
NP437_08430	COG0454	-acetyltransferase
NP437_08435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP437_08440	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NP437_08445	COG2001	Belongs to the MraZ family
NP437_08450	COG0275	rRNA processing
NP437_08455	COG4839	cell division protein FtsL
NP437_08460	COG0768	penicillin binding
NP437_08465	COG0768	penicillin binding
NP437_08470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NP437_08475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP437_08480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP437_08485	COG0772	Belongs to the SEDS family
NP437_08490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP437_08495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NP437_08500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NP437_08505	COG3879	Bacterial protein of unknown function (DUF881)
NP437_08510	COG3879	Bacterial protein of unknown function (DUF881)
NP437_08515	COG3856	small basic protein
NP437_08520	COG0849	cell division
NP437_08525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NP437_08530	COG1404	Belongs to the peptidase S8 family
NP437_08530	COG4412	M6 family metalloprotease domain protein
NP437_08540	COG1191	sigma factor activity
NP437_08545	COG1191	sigma factor activity
NP437_08550	COG1119	ATPase activity
NP437_08555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP437_08560	COG1873	PFAM PRC-barrel domain
NP437_08565	COG1496	oxidoreductase activity
NP437_08570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NP437_08575	COG1799	cell septum assembly
NP437_08580	COG0762	integral membrane protein
NP437_08585	COG2302	S4 RNA-binding domain
NP437_08590	COG3599	regulation of cell shape
NP437_08595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NP437_08600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP437_08605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NP437_08610	COG0564	pseudouridine synthase activity
NP437_08615	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NP437_08620	COG2233	PERMEase
NP437_08625	COG0540	Belongs to the ATCase OTCase family
NP437_08630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP437_08635	COG0505	Belongs to the CarA family
NP437_08640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP437_08645	COG0543	2 iron, 2 sulfur cluster binding
NP437_08650	COG0167	dihydroorotate dehydrogenase activity
NP437_08655	COG0284	orotidine-5'-phosphate decarboxylase activity
NP437_08660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NP437_08665	COG0175	sulfate reduction
NP437_08670	COG0306	phosphate transporter
NP437_08675	COG2046	Belongs to the sulfate adenylyltransferase family
NP437_08680	COG0529	Catalyzes the synthesis of activated sulfate
NP437_08685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP437_08690	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NP437_08695	COG1648	precorrin-2 dehydrogenase activity
NP437_08705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP437_08710	COG1561	YicC-like family, N-terminal region
NP437_08720	COG0194	GDP metabolic process
NP437_08725	COG1758	RNA polymerase activity
NP437_08730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP437_08735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP437_08740	COG0242	peptide deformylase activity
NP437_08745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NP437_08750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NP437_08750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP437_08755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NP437_08760	COG0631	protein serine/threonine phosphatase activity
NP437_08765	COG0515	serine threonine protein kinase
NP437_08765	COG2815	serine threonine protein kinase
NP437_08770	COG1162	GTPase activity
NP437_08775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NP437_08780	COG1564	THIamine pyrophosphokinase
NP437_08790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NP437_08795	COG1302	Protein conserved in bacteria
NP437_08800	COG1461	Dihydroxyacetone kinase
NP437_08805	COG1760	l-serine dehydratase
NP437_08810	COG1760	l-serine dehydratase
NP437_08815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NP437_08820	COG2050	protein possibly involved in aromatic compounds catabolism
NP437_08820	COG1349	DNA-binding transcription factor activity
NP437_08825	COG0416	fatty acid biosynthetic process
NP437_08830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP437_08835	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_08845	COG0571	ribonuclease III activity
NP437_08850	COG1196	nuclear chromosome segregation
NP437_08855	COG0552	protein localization to endoplasmic reticulum
NP437_08865	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NP437_08870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NP437_08875	COG0228	four-way junction DNA binding
NP437_08880	COG1837	Belongs to the UPF0109 family
NP437_08890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NP437_08895	COG0336	Belongs to the RNA methyltransferase TrmD family
NP437_08900	COG0335	large ribosomal subunit rRNA binding
NP437_08905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP437_08910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP437_08920	COG2257	FlhB HrpN YscU SpaS Family
NP437_08925	COG0045	succinate-CoA ligase (ADP-forming) activity
NP437_08930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NP437_08935	COG0758	DNA mediated transformation
NP437_08940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP437_08945	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NP437_08950	COG4974	Belongs to the 'phage' integrase family
NP437_08955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NP437_08960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NP437_08965	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP437_08970	COG1815	bacterial-type flagellum-dependent cell motility
NP437_08975	COG1558	bacterial-type flagellum-dependent cell motility
NP437_08980	COG1677	Flagellar hook-basal body complex protein FliE
NP437_08990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP437_08995	COG1317	bacterial-type flagellum organization
NP437_09000	COG1157	protein secretion by the type III secretion system
NP437_09005	COG2882	bacterial-type flagellum organization
NP437_09010	COG3334	PFAM MgtE intracellular
NP437_09015	COG3144	bacterial-type flagellum assembly
NP437_09020	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NP437_09025	COG4786	Flagellar basal body rod
NP437_09030	COG1582	Flagellar protein (FlbD)
NP437_09035	COG1580	Controls the rotational direction of flagella during chemotaxis
NP437_09040	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP437_09045	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP437_09045	COG1776	CheC inhibitor of MCP methylation
NP437_09050	COG2201	protein-glutamate methylesterase activity
NP437_09055	COG3190	flagellar
NP437_09060	COG1338	Plays a role in the flagellum-specific transport system
NP437_09065	COG1987	bacterial-type flagellum assembly
NP437_09070	COG1684	flagellar biosynthetic protein fliR
NP437_09075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP437_09080	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP437_09085	COG1419	protein localization to endoplasmic reticulum
NP437_09090	COG0455	bacterial-type flagellum organization
NP437_09095	COG2201	protein-glutamate methylesterase activity
NP437_09100	COG0643	Histidine kinase
NP437_09100	COG2198	Histidine kinase
NP437_09105	COG0835	chemotaxis
NP437_09115	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NP437_09120	COG1191	sigma factor activity
NP437_09130	COG0052	Belongs to the universal ribosomal protein uS2 family
NP437_09135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NP437_09140	COG0528	UMP kinase activity
NP437_09145	COG0233	cytoplasmic translational termination
NP437_09150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NP437_09155	COG4589	Belongs to the CDS family
NP437_09160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NP437_09165	COG0750	zinc metalloprotease
NP437_09170	COG0442	prolyl-tRNA aminoacylation
NP437_09175	COG2176	DNA-directed DNA polymerase activity
NP437_09180	COG0779	Required for maturation of 30S ribosomal subunits
NP437_09185	COG0195	Participates in both transcription termination and antitermination
NP437_09190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NP437_09195	COG1358	cellular component organization or biogenesis
NP437_09200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NP437_09205	COG1550	Protein conserved in bacteria
NP437_09210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NP437_09215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NP437_09220	COG0196	riboflavin kinase activity
NP437_09225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NP437_09230	COG1185	polyribonucleotide nucleotidyltransferase activity
NP437_09235	COG0726	polysaccharide deacetylase
NP437_09240	COG0612	Peptidase, M16
NP437_09245	COG1873	PFAM PRC-barrel domain
NP437_09250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP437_09255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP437_09260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NP437_09265	COG0527	aspartate kinase activity
NP437_09270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP437_09275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP437_09280	COG0740	serine-type endopeptidase activity
NP437_09290	COG1674	ftsk spoiiie
NP437_09290	COG4980	gas vesicle protein
NP437_09295	COG2188	Transcriptional regulator
NP437_09300	COG2814	Major facilitator Superfamily
NP437_09305	COG0612	Peptidase, M16
NP437_09310	COG0612	Peptidase, M16
NP437_09315	COG0300	oxidoreductase activity
NP437_09330	COG1426	Protein conserved in bacteria
NP437_09335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NP437_09345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NP437_09350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP437_09355	COG1418	mRNA catabolic process
NP437_09360	COG1692	metallophosphoesterase
NP437_09365	COG2359	stage V sporulation protein S
NP437_09370	COG1063	alcohol dehydrogenase
NP437_09375	COG0156	8-amino-7-oxononanoate synthase activity
NP437_09380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP437_09385	COG4550	Control of competence regulator ComK, YlbF/YmcA
NP437_09395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NP437_09400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NP437_09505	COG3226	Transcriptional regulator
NP437_09515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP437_09520	COG1404	Belongs to the peptidase S8 family
NP437_09530	COG4195	phage-related replication protein
NP437_09535	COG1764	response to oxidative stress
NP437_09540	COG2076	Multidrug Resistance protein
NP437_09545	COG2076	Multidrug Resistance protein
NP437_09560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NP437_09565	COG1923	regulation of RNA biosynthetic process
NP437_09580	COG1780	Probably involved in ribonucleotide reductase function
NP437_09585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP437_09590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP437_09595	COG4112	unkown
NP437_09600	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP437_09605	COG0464	growth
NP437_09610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NP437_09615	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NP437_09620	COG0789	Transcriptional regulator
NP437_09625	COG0174	glutamine synthetase
NP437_09630	COG4974	Belongs to the 'phage' integrase family
NP437_09650	COG3645	SOS response
NP437_09650	COG3646	Phage regulatory protein
NP437_09800	COG3953	SLT domain
NP437_09800	COG5412	phage tail tape measure protein
NP437_09845	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP437_09845	COG3409	Peptidoglycan-binding domain 1 protein
NP437_09845	COG1388	LysM domain
NP437_09855	COG5444	nuclease activity
NP437_09890	COG4282	regulation of fungal-type cell wall biogenesis
NP437_09925	COG3655	Transcriptional regulator
NP437_09950	COG0135	phosphoribosylanthranilate isomerase activity
NP437_09960	COG2211	Major facilitator Superfamily
NP437_09975	COG3507	Belongs to the glycosyl hydrolase 43 family
NP437_09980	COG1940	carbohydrate kinase activity
NP437_09985	COG2115	Belongs to the xylose isomerase family
NP437_09990	COG1070	Carbohydrate kinase
NP437_10000	COG3328	transposase activity
NP437_10005	COG1525	nuclease
NP437_10010	COG2814	Major facilitator Superfamily
NP437_10015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP437_10030	COG0756	dUTP diphosphatase activity
NP437_10070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP437_10090	COG3832	glyoxalase III activity
NP437_10130	COG4195	phage-related replication protein
NP437_10140	COG0346	lactoylglutathione lyase activity
NP437_10150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NP437_10155	COG1388	LysM domain
NP437_10160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP437_10165	COG4224	UPF0291 protein
NP437_10170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NP437_10180	COG3763	UPF0154 protein
NP437_10190	COG0785	Cytochrome C biogenesis protein
NP437_10195	COG2201	protein-glutamate methylesterase activity
NP437_10200	COG4846	Membrane protein involved in cytochrome C biogenesis
NP437_10210	COG0071	Belongs to the small heat shock protein (HSP20) family
NP437_10225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NP437_10230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP437_10250	COG0824	Thioesterase
NP437_10260	COG4841	protein insertion into membrane
NP437_10265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NP437_10270	COG1832	CoA-binding protein
NP437_10275	COG0187	DNA topoisomerase II activity
NP437_10280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP437_10295	COG1115	amino acid carrier protein
NP437_10300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NP437_10310	COG5520	Belongs to the glycosyl hydrolase 30 family
NP437_10320	COG2246	polysaccharide biosynthetic process
NP437_10325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP437_10330	COG0586	Pfam SNARE associated Golgi protein
NP437_10335	COG2404	hydrolase activity, acting on ester bonds
NP437_10340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP437_10345	COG1024	Enoyl-CoA hydratase
NP437_10350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP437_10355	COG0511	ligase activity, forming carbon-carbon bonds
NP437_10360	COG0439	Biotin carboxylase
NP437_10365	COG0318	PFAM AMP-dependent synthetase and ligase
NP437_10370	COG1960	acyl-CoA dehydrogenase activity
NP437_10385	COG1649	PFAM Uncharacterised BCR, COG1649
NP437_10400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP437_10405	COG2027	D-alanyl-D-alanine carboxypeptidase
NP437_10410	COG2017	converts alpha-aldose to the beta-anomer
NP437_10415	COG0534	Mate efflux family protein
NP437_10435	COG0582	viral genome integration into host DNA
NP437_10440	COG0166	Belongs to the GPI family
NP437_10445	COG0405	Gamma-glutamyltransferase
NP437_10450	COG0583	DNA-binding transcription factor activity
NP437_10455	COG0604	alcohol dehydrogenase
NP437_10460	COG0493	'glutamate synthase
NP437_10465	COG0067	glutamate synthase
NP437_10465	COG0069	glutamate synthase activity
NP437_10465	COG0070	glutamate synthase
NP437_10470	COG0583	DNA-binding transcription factor activity
NP437_10500	COG0300	oxidoreductase activity
NP437_10505	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NP437_10515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP437_10530	COG1131	(ABC) transporter
NP437_10540	COG2814	Major facilitator Superfamily
NP437_10545	COG3328	transposase activity
NP437_10575	COG3328	transposase activity
NP437_10630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP437_10635	COG2226	methyltransferase
NP437_10640	COG2211	Major facilitator Superfamily
NP437_10645	COG3328	transposase activity
NP437_10675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP437_10695	COG5444	nuclease activity
NP437_10700	COG4282	regulation of fungal-type cell wall biogenesis
NP437_10705	COG1231	oxidoreductase activity
NP437_10710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP437_10715	COG2207	Transcriptional regulator
NP437_10715	COG0662	Cupin 2, conserved barrel domain protein
NP437_10720	COG0456	acetyltransferase
NP437_10725	COG1309	transcriptional regulator
NP437_10730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP437_10735	COG3708	Transcriptional regulator
NP437_10740	COG2378	regulation of single-species biofilm formation
NP437_10750	COG0640	Transcriptional regulator
NP437_10755	COG0741	lytic transglycosylase activity
NP437_10760	COG2322	membrane
NP437_10775	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP437_10780	COG3239	Fatty acid desaturase
NP437_10785	COG4585	Histidine kinase
NP437_10790	COG2197	response regulator
NP437_10795	COG3584	3D domain protein
NP437_10795	COG1388	LysM domain
NP437_10800	COG0514	ATP-dependent DNA helicase (RecQ)
NP437_10810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP437_10815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP437_10830	COG0071	Belongs to the small heat shock protein (HSP20) family
NP437_10855	COG1012	belongs to the aldehyde dehydrogenase family
NP437_10860	COG1657	PFAM Prenyltransferase squalene oxidase
NP437_10865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP437_10870	COG0733	neurotransmitter:sodium symporter activity
NP437_10875	COG0385	Bile acid
NP437_10880	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP437_10885	COG0567	Dehydrogenase, E1 component
NP437_10890	COG4548	von Willebrand factor, type A
NP437_10895	COG0714	Associated with various cellular activities
NP437_10900	COG2032	superoxide dismutase activity
NP437_10905	COG0791	NLP P60 protein
NP437_10905	COG1388	LysM domain
NP437_10910	COG1819	glycosyl
NP437_10915	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP437_10920	COG0534	Mate efflux family protein
NP437_10925	COG1366	Belongs to the anti-sigma-factor antagonist family
NP437_10930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP437_10935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP437_10945	COG2962	Rard protein
NP437_10960	COG2610	gluconate transmembrane transporter activity
NP437_10965	COG2610	gluconate transmembrane transporter activity
NP437_10970	COG1942	4-Oxalocrotonate Tautomerase
NP437_10975	COG1733	regulation of RNA biosynthetic process
NP437_10980	COG0778	Nitroreductase
NP437_10990	COG0400	carboxylic ester hydrolase activity
NP437_11005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP437_11010	COG0793	Belongs to the peptidase S41A family
NP437_11010	COG3409	Peptidoglycan-binding domain 1 protein
NP437_11015	COG2226	methyltransferase
NP437_11025	COG1876	peptidase activity
NP437_11030	COG0813	purine-nucleoside phosphorylase activity
NP437_11045	COG0671	phosphoesterase, PA-phosphatase related
NP437_11065	COG4479	Belongs to the UPF0346 family
NP437_11075	COG1509	lysine 2,3-aminomutase activity
NP437_11080	COG0456	acetyltransferase
NP437_11085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP437_11090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP437_11095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP437_11100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP437_11115	COG0456	acetyltransferase
NP437_11120	COG0463	Glycosyl transferase, family 2
NP437_11135	COG4641	Protein conserved in bacteria
NP437_11140	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
NP437_11145	COG1086	Polysaccharide biosynthesis protein
NP437_11150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP437_11155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP437_11160	COG1846	Transcriptional regulator
NP437_11165	COG0534	Mate efflux family protein
NP437_11175	COG4698	Protein conserved in bacteria
NP437_11180	COG2755	lipolytic protein G-D-S-L family
NP437_11185	COG1999	signal sequence binding
NP437_11195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NP437_11200	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP437_11205	COG1272	protein, Hemolysin III
NP437_11210	COG0204	Acyl-transferase
NP437_11215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP437_11220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP437_11230	COG2136	Putative SAM-dependent methyltransferase
NP437_11230	COG2521	methyltransferase
NP437_11240	COG0129	dihydroxy-acid dehydratase activity
NP437_11245	COG1413	lyase activity
NP437_11250	COG1418	mRNA catabolic process
NP437_11255	COG0386	Belongs to the glutathione peroxidase family
NP437_11260	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NP437_11265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP437_11275	COG1278	Cold shock
NP437_11295	COG0328	RNA-DNA hybrid ribonuclease activity
NP437_11300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NP437_11305	COG0328	RNA-DNA hybrid ribonuclease activity
NP437_11315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP437_11330	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP437_11340	COG1755	Isoprenylcysteine carboxyl methyltransferase
NP437_11345	COG3424	synthase
NP437_11350	COG2233	PERMEase
NP437_11355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP437_11360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NP437_11370	COG0800	Aldolase
NP437_11375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP437_11380	COG1609	Transcriptional regulator
NP437_11385	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NP437_11390	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_11395	COG1199	ATP-dependent helicase activity
NP437_11410	COG0116	Belongs to the methyltransferase superfamily
NP437_11425	COG4474	Belongs to the UPF0398 family
NP437_11440	COG3359	exonuclease
NP437_11445	COG1205	dead DEAH box helicase
NP437_11445	COG1111	helicase
NP437_11450	COG2190	(PTS) system
NP437_11455	COG0071	Belongs to the small heat shock protein (HSP20) family
NP437_11490	COG3331	DNA recombination
NP437_11495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP437_11495	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP437_11505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NP437_11510	COG3935	DnaD domain protein
NP437_11515	COG0017	Asparaginyl-tRNA synthetase
NP437_11520	COG0436	Aminotransferase
NP437_11525	COG5353	protein conserved in bacteria
NP437_11535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NP437_11535	COG1199	ATP-dependent helicase activity
NP437_11540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NP437_11545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NP437_11550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NP437_11555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NP437_11555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NP437_11560	COG0617	tRNA 3'-terminal CCA addition
NP437_11565	COG0438	transferase activity, transferring glycosyl groups
NP437_11570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP437_11575	COG1803	Methylglyoxal synthase
NP437_11580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NP437_11585	COG1694	Mazg nucleotide pyrophosphohydrolase
NP437_11590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP437_11600	COG4347	Protein of unknown function (DUF1405)
NP437_11605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP437_11605	COG2010	Cytochrome c
NP437_11610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP437_11615	COG0723	plastoquinol--plastocyanin reductase activity
NP437_11625	COG5582	Belongs to the UPF0302 family
NP437_11630	COG0457	Tetratricopeptide repeat
NP437_11635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NP437_11640	COG0287	Prephenate dehydrogenase
NP437_11655	COG0133	tryptophan synthase activity
NP437_11660	COG0135	phosphoribosylanthranilate isomerase activity
NP437_11670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NP437_11675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP437_11680	COG4401	Chorismate mutase type I
NP437_11685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NP437_11690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NP437_11695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NP437_11700	COG0105	UTP biosynthetic process
NP437_11705	COG0142	geranyltranstransferase activity
NP437_11710	COG2226	methyltransferase
NP437_11715	COG0142	geranyltranstransferase activity
NP437_11725	COG0302	gtp cyclohydrolase
NP437_11730	COG0776	regulation of translation
NP437_11735	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP437_11750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NP437_11755	COG1160	GTP binding
NP437_11780	COG1304	FMN binding
NP437_11785	COG0539	negative regulation of cytoplasmic translation
NP437_11790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NP437_11800	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NP437_11805	COG2959	enzyme of heme biosynthesis
NP437_11810	COG3773	Cell wall hydrolase
NP437_11810	COG3409	Peptidoglycan-binding domain 1 protein
NP437_11815	COG2339	peptidase activity
NP437_11820	COG0492	ferredoxin-NADP+ reductase activity
NP437_11825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP437_11830	COG4862	establishment of competence for transformation
NP437_11835	COG1408	metallophosphoesterase
NP437_11845	COG1388	LysM domain
NP437_11850	COG1266	CAAX protease self-immunity
NP437_11855	COG0514	ATP-dependent DNA helicase (RecQ)
NP437_11860	COG4955	Helix-turn-helix domain
NP437_11865	COG1141	Ferredoxin
NP437_11870	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NP437_11875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP437_11880	COG0710	3-dehydroquinate dehydratase activity
NP437_11890	COG1595	DNA-templated transcription, initiation
NP437_11895	COG5002	protein histidine kinase activity
NP437_11900	COG0745	RESPONSE REGULATOR receiver
NP437_11905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP437_11910	COG1333	cytochrome c biogenesis protein
NP437_11915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP437_11920	COG1187	pseudouridine synthase activity
NP437_11925	COG0700	Nucleoside recognition
NP437_11930	COG2715	membrane protein required for spore maturation
NP437_11935	COG1686	Belongs to the peptidase S11 family
NP437_11945	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NP437_11950	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NP437_11955	COG1547	Domain of unknown function (DUF309)
NP437_11960	COG0456	acetyltransferase
NP437_11965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NP437_11970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP437_11970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP437_11975	COG0307	riboflavin synthase, alpha
NP437_11980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP437_11980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP437_11990	COG0681	Belongs to the peptidase S26 family
NP437_12000	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
NP437_12045	COG3328	transposase activity
NP437_12095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP437_12105	COG4086	secreted protein
NP437_12110	COG0019	diaminopimelate decarboxylase activity
NP437_12115	COG0697	spore germination
NP437_12130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP437_12150	COG1191	sigma factor activity
NP437_12155	COG2172	sigma factor antagonist activity
NP437_12160	COG1366	Belongs to the anti-sigma-factor antagonist family
NP437_12165	COG1686	Belongs to the peptidase S11 family
NP437_12170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NP437_12175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NP437_12180	COG4974	Belongs to the 'phage' integrase family
NP437_12190	COG0735	belongs to the Fur family
NP437_12195	COG1300	Membrane
NP437_12205	COG0281	malic enzyme
NP437_12210	COG1757	Na H antiporter
NP437_12215	COG1027	Aspartate ammonia-lyase
NP437_12220	COG0252	asparaginase activity
NP437_12225	COG1396	sequence-specific DNA binding
NP437_12230	COG1379	DNA repair
NP437_12235	COG0494	nUDIX hydrolase
NP437_12245	COG0667	Aldo Keto reductase
NP437_12255	COG1073	alpha beta
NP437_12265	COG4918	Iron-sulphur cluster biosynthesis
NP437_12270	COG0456	acetyltransferase
NP437_12270	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NP437_12275	COG2329	Antibiotic biosynthesis monooxygenase
NP437_12280	COG0456	acetyltransferase
NP437_12290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP437_12300	COG2211	Major facilitator Superfamily
NP437_12310	COG0346	lactoylglutathione lyase activity
NP437_12315	COG1072	(Pantothenic acid kinase))
NP437_12320	COG3048	D-serine ammonia-lyase activity
NP437_12325	COG0300	oxidoreductase activity
NP437_12330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP437_12335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP437_12340	COG4187	Peptidase family M20/M25/M40
NP437_12345	COG1902	pentaerythritol trinitrate reductase activity
NP437_12360	COG0596	Alpha beta hydrolase
NP437_12370	COG1234	tRNA 3'-trailer cleavage
NP437_12375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NP437_12380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP437_12385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP437_12395	COG0706	membrane insertase activity
NP437_12400	COG3361	conserved protein (COG2071)
NP437_12405	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP437_12415	COG0346	lactoylglutathione lyase activity
NP437_12425	COG1376	ErfK ybiS ycfS ynhG family protein
NP437_12430	COG4129	membrane
NP437_12435	COG1126	abc transporter atp-binding protein
NP437_12440	COG0765	amino acid transport
NP437_12445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP437_12455	COG1597	lipid kinase activity
NP437_12465	COG0789	Transcriptional regulator
NP437_12465	COG4978	Transcriptional regulator
NP437_12470	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP437_12475	COG0022	dehydrogenase e1 component
NP437_12480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP437_12485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP437_12490	COG3426	butyrate kinase activity
NP437_12495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP437_12500	COG0280	phosphate acetyltransferase
NP437_12505	COG3829	transcription factor binding
NP437_12505	COG3290	protein histidine kinase activity
NP437_12515	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NP437_12520	COG2079	MmgE PrpD family protein
NP437_12525	COG0372	Belongs to the citrate synthase family
NP437_12530	COG1960	acyl-CoA dehydrogenase activity
NP437_12535	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP437_12540	COG0183	Belongs to the thiolase family
NP437_12545	COG0584	glycerophosphoryl diester phosphodiesterase
NP437_12550	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP437_12565	COG1902	pentaerythritol trinitrate reductase activity
NP437_12570	COG0745	RESPONSE REGULATOR receiver
NP437_12575	COG0750	zinc metalloprotease
NP437_12580	COG0497	DNA recombination
NP437_12585	COG1438	arginine binding
NP437_12590	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NP437_12595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NP437_12600	COG0142	geranyltranstransferase activity
NP437_12605	COG1722	exodeoxyribonuclease VII activity
NP437_12610	COG1570	exodeoxyribonuclease VII activity
NP437_12615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NP437_12620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP437_12625	COG1302	Protein conserved in bacteria
NP437_12630	COG0439	Biotin carboxylase
NP437_12635	COG0511	ligase activity, forming carbon-carbon bonds
NP437_12680	COG3854	ATPases associated with a variety of cellular activities
NP437_12690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NP437_12695	COG0006	proline dipeptidase activity
NP437_12700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NP437_12710	COG3872	metal-dependent enzyme
NP437_12720	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP437_12725	COG1321	iron dependent repressor
NP437_12730	COG0095	Lipoate-protein ligase
NP437_12735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP437_12740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP437_12745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP437_12750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NP437_12755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP437_12770	COG1396	sequence-specific DNA binding
NP437_12780	COG0681	Belongs to the peptidase S26 family
NP437_12805	COG4940	Competence protein ComGF
NP437_12815	COG4970	Tfp pilus assembly protein FimT
NP437_12820	COG4537	Required for transformation and DNA binding
NP437_12825	COG1459	type II secretion system
NP437_12830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP437_12835	COG0517	IMP dehydrogenase activity
NP437_12840	COG0598	Magnesium transport protein CorA
NP437_12845	COG1253	flavin adenine dinucleotide binding
NP437_12850	COG1366	Belongs to the anti-sigma-factor antagonist family
NP437_12860	COG1393	Belongs to the ArsC family
NP437_12870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP437_12880	COG0011	TIGRFAM Protein of
NP437_12890	COG2866	Carboxypeptidase
NP437_12895	COG1368	sulfuric ester hydrolase activity
NP437_12900	COG1940	carbohydrate kinase activity
NP437_12905	COG4483	Protein conserved in bacteria
NP437_12910	COG0705	Rhomboid family
NP437_12910	COG0457	Tetratricopeptide repeat
NP437_12920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NP437_12930	COG0438	transferase activity, transferring glycosyl groups
NP437_12945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP437_12950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP437_12955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP437_12960	COG0581	inorganic phosphate transmembrane transporter activity
NP437_12965	COG0573	inorganic phosphate transmembrane transporter activity
NP437_12970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NP437_12975	COG0768	penicillin binding
NP437_12980	COG0477	Major facilitator Superfamily
NP437_12985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP437_12990	COG2839	Protein conserved in bacteria
NP437_12995	COG5521	maltodextrose utilization protein MalA
NP437_13000	COG1388	LysM domain
NP437_13005	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NP437_13010	COG4709	membrane
NP437_13015	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NP437_13020	COG0735	belongs to the Fur family
NP437_13025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP437_13035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NP437_13040	COG0513	Belongs to the DEAD box helicase family
NP437_13050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NP437_13055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NP437_13060	COG2384	SAM-dependent methyltransferase
NP437_13065	COG2010	Cytochrome c
NP437_13070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NP437_13075	COG0358	DNA primase activity
NP437_13080	COG1671	Belongs to the UPF0178 family
NP437_13085	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NP437_13090	COG0517	IMP dehydrogenase activity
NP437_13095	COG0751	glycine-tRNA ligase activity
NP437_13100	COG0752	glycyl-tRNA synthetase alpha subunit
NP437_13105	COG1381	Involved in DNA repair and RecF pathway recombination
NP437_13115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NP437_13120	COG0295	cytidine deaminase activity
NP437_13125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NP437_13130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NP437_13135	COG1480	7TM receptor with intracellular HD hydrolase
NP437_13140	COG1702	phosphate starvation-inducible protein PhoH
NP437_13145	COG0561	phosphatase activity
NP437_13160	COG4864	UPF0365 protein
NP437_13165	COG1030	water channel activity
NP437_13170	COG1610	YqeY-like protein
NP437_13180	COG1283	sodium-dependent phosphate transmembrane transporter activity
NP437_13185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP437_13190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NP437_13195	COG2264	protein methyltransferase activity
NP437_13200	COG0484	heat shock protein binding
NP437_13205	COG0443	Heat shock 70 kDa protein
NP437_13210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NP437_13215	COG1420	regulation of RNA biosynthetic process
NP437_13220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP437_13225	COG0481	GTPase activity
NP437_13235	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP437_13240	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NP437_13245	COG0268	Binds directly to 16S ribosomal RNA
NP437_13250	COG1466	dna polymerase III delta subunit
NP437_13265	COG0658	competence protein
NP437_13265	COG2333	competence protein COMEC
NP437_13270	COG2131	deaminase
NP437_13275	COG1555	photosystem II stabilization
NP437_13275	COG1596	polysaccharide export
NP437_13280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP437_13285	COG2226	methyltransferase
NP437_13290	COG0799	negative regulation of ribosome biogenesis
NP437_13295	COG1713	HD superfamily hydrolase involved in NAD metabolism
NP437_13300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NP437_13305	COG1534	Rna-binding protein
NP437_13310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP437_13315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP437_13320	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NP437_13330	COG2755	lipolytic protein G-D-S-L family
NP437_13335	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP437_13335	COG3409	Peptidoglycan-binding domain 1 protein
NP437_13340	COG0398	Pfam SNARE associated Golgi protein
NP437_13345	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NP437_13355	COG3209	COG3209 Rhs family protein
NP437_13375	COG0114	fumarate hydratase activity
NP437_13380	COG0583	DNA-binding transcription factor activity
NP437_13395	COG0457	Tetratricopeptide repeat
NP437_13535	COG4978	Transcriptional regulator
NP437_13535	COG0789	Transcriptional regulator
NP437_13540	COG2814	Major facilitator Superfamily
NP437_13545	COG0456	acetyltransferase
NP437_13550	COG1253	flavin adenine dinucleotide binding
NP437_13560	COG0697	spore germination
NP437_13565	COG0583	DNA-binding transcription factor activity
NP437_13570	COG2072	flavoprotein involved in K transport
NP437_13575	COG1230	cation diffusion facilitator family transporter
NP437_13590	COG1114	Component of the transport system for branched-chain amino acids
NP437_13595	COG1687	branched-chain amino acid
NP437_13605	COG1522	sequence-specific DNA binding
NP437_13610	COG2732	(Barnase) inhibitor
NP437_13615	COG2124	cytochrome p450
NP437_13625	COG1335	isochorismatase
NP437_13645	COG2318	DinB family
NP437_13655	COG2070	2-Nitropropane dioxygenase
NP437_13660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP437_13680	COG3443	Belongs to the bacterial solute-binding protein 9 family
NP437_13685	COG1595	DNA-templated transcription, initiation
NP437_13690	COG0667	Aldo Keto reductase
NP437_13695	COG3409	Peptidoglycan-binding domain 1 protein
NP437_13700	COG5566	PFAM Mor transcription activator
NP437_13705	COG0596	Alpha beta hydrolase
NP437_13710	COG4991	sh3 domain protein
NP437_13715	COG4991	sh3 domain protein
NP437_13725	COG0346	lactoylglutathione lyase activity
NP437_13735	COG5577	PFAM Coat F domain
NP437_13740	COG1063	alcohol dehydrogenase
NP437_13750	COG5577	PFAM Coat F domain
NP437_13755	COG0789	Transcriptional regulator
NP437_13765	COG1064	alcohol dehydrogenase
NP437_13770	COG0693	protein deglycase activity
NP437_13775	COG1621	beta-fructofuranosidase activity
NP437_13780	COG3716	PTS system mannose fructose sorbose family IID component
NP437_13785	COG3715	PTS system
NP437_13790	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_13795	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP437_13800	COG3933	PFAM sigma-54 factor interaction domain-containing protein
NP437_13800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP437_13810	COG1113	amino acid transport
NP437_13815	COG1280	lysine exporter protein (LysE YggA)
NP437_13820	COG1378	Sugar-specific transcriptional regulator TrmB
NP437_13825	COG1595	DNA-templated transcription, initiation
NP437_13850	COG1309	transcriptional regulator
NP437_13855	COG2226	methyltransferase
NP437_13870	COG2116	formate transmembrane transporter activity
NP437_13875	COG5609	conserved protein (DUF2294)
NP437_13880	COG3383	formate dehydrogenase (NAD+) activity
NP437_13885	COG2427	Protein of unknown function (DUF1641)
NP437_13900	COG0626	cystathionine gamma-synthase activity
NP437_13905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP437_13910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NP437_13915	COG2226	methyltransferase
NP437_13930	COG0768	penicillin binding
NP437_13935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP437_13940	COG0572	uridine kinase
NP437_13945	COG0826	peptidase U32
NP437_13950	COG0826	peptidase U32
NP437_13955	COG4122	O-methyltransferase activity
NP437_13960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP437_13965	COG3906	Belongs to the UPF0473 family
NP437_13970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NP437_13975	COG4472	Bacterial protein of unknown function (DUF965)
NP437_13980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NP437_13985	COG0628	permease
NP437_13990	COG1126	abc transporter atp-binding protein
NP437_13995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP437_14000	COG0765	amino acid transport
NP437_14005	COG0765	amino acid transport
NP437_14020	COG3881	PFAM PRC-barrel domain
NP437_14025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NP437_14030	COG0457	Tetratricopeptide repeat
NP437_14035	COG0482	sulfurtransferase activity
NP437_14040	COG1104	cysteine desulfurase activity
NP437_14045	COG1959	2 iron, 2 sulfur cluster binding
NP437_14050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NP437_14055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NP437_14065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NP437_14070	COG0124	histidyl-tRNA synthetase
NP437_14080	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP437_14080	COG3103	Sh3 type 3 domain protein
NP437_14080	COG4991	sh3 domain protein
NP437_14085	COG1490	D-aminoacyl-tRNA deacylase activity
NP437_14090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP437_14095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP437_14100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NP437_14100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NP437_14105	COG5416	Lipopolysaccharide assembly protein A domain
NP437_14110	COG0490	domain, Protein
NP437_14115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP437_14115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP437_14125	COG2244	polysaccharide biosynthetic process
NP437_14130	COG2323	membrane
NP437_14140	COG1862	Preprotein translocase
NP437_14145	COG0343	queuine tRNA-ribosyltransferase activity
NP437_14150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NP437_14160	COG2255	four-way junction helicase activity
NP437_14165	COG0632	four-way junction helicase activity
NP437_14175	COG2814	Major facilitator Superfamily
NP437_14180	COG0673	inositol 2-dehydrogenase activity
NP437_14185	COG2112	serine threonine protein kinase
NP437_14210	COG1115	amino acid carrier protein
NP437_14215	COG0217	transcriptional regulatory protein
NP437_14225	COG1388	LysM domain
NP437_14230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NP437_14235	COG0157	Belongs to the NadC ModD family
NP437_14240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NP437_14245	COG1104	cysteine desulfurase activity
NP437_14250	COG1827	regulation of RNA biosynthetic process
NP437_14255	COG0077	Prephenate dehydratase
NP437_14260	COG4492	Belongs to the UPF0735 family
NP437_14265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NP437_14270	COG3290	protein histidine kinase activity
NP437_14280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NP437_14285	COG2868	ribosomal protein
NP437_14290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NP437_14295	COG1994	Peptidase M50
NP437_14300	COG0739	heme binding
NP437_14305	COG2894	cell division
NP437_14310	COG0850	regulation of cytokinetic process
NP437_14315	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NP437_14325	COG1077	Cell shape determining protein MreB Mrl
NP437_14330	COG2003	Belongs to the UPF0758 family
NP437_14335	COG0424	maF-like protein
NP437_14345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NP437_14350	COG0285	dihydrofolate synthase activity
NP437_14355	COG0525	valine-tRNA ligase activity
NP437_14365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP437_14370	COG1388	LysM domain
NP437_14375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP437_14380	COG0113	porphobilinogen synthase activity
NP437_14385	COG1587	Uroporphyrinogen-III synthase
NP437_14390	COG0181	hydroxymethylbilane synthase activity
NP437_14395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP437_14400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NP437_14410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NP437_14415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NP437_14420	COG0470	DNA polymerase III
NP437_14420	COG1067	ATP-dependent peptidase activity
NP437_14425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NP437_14430	COG0544	peptidyl-prolyl cis-trans isomerase activity
NP437_14435	COG1477	protein flavinylation
NP437_14435	COG0457	Tetratricopeptide repeat
NP437_14440	COG0066	3-isopropylmalate dehydratase activity
NP437_14445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NP437_14450	COG0473	3-isopropylmalate dehydrogenase activity
NP437_14455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP437_14460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NP437_14465	COG0440	acetolactate synthase activity
NP437_14470	COG0028	Belongs to the TPP enzyme family
NP437_14485	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NP437_14510	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NP437_14540	COG0622	Phosphoesterase
NP437_14545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NP437_14550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NP437_14555	COG5401	PFAM Sporulation and spore germination
NP437_14560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP437_14565	COG1846	Transcriptional regulator
NP437_14570	COG2197	response regulator
NP437_14575	COG0824	Thioesterase
NP437_14580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NP437_14585	COG1053	succinate dehydrogenase
NP437_14590	COG2009	succinate dehydrogenase
NP437_14595	COG1719	4-vinyl reductase, 4VR
NP437_14600	COG0527	aspartate kinase activity
NP437_14605	COG0322	excinuclease ABC activity
NP437_14610	COG3118	belongs to the thioredoxin family
NP437_14615	COG3534	alpha-L-arabinofuranosidase
NP437_14620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NP437_14625	COG2086	electron transfer activity
NP437_14630	COG1024	Enoyl-CoA hydratase
NP437_14635	COG1309	transcriptional regulator
NP437_14640	COG0318	PFAM AMP-dependent synthetase and ligase
NP437_14645	COG3766	membrane
NP437_14650	COG1193	negative regulation of DNA recombination
NP437_14655	COG1796	DNA polymerase
NP437_14655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP437_14660	COG1286	toxin biosynthetic process
NP437_14665	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NP437_14670	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP437_14675	COG0072	phenylalanine-tRNA ligase activity
NP437_14675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP437_14680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NP437_14690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP437_14700	COG3835	regulator
NP437_14705	COG0277	FAD linked oxidase domain protein
NP437_14710	COG0247	lactate metabolic process
NP437_14715	COG0346	lactoylglutathione lyase activity
NP437_14725	COG1966	Carbon starvation protein
NP437_14730	COG3534	alpha-L-arabinofuranosidase
NP437_14735	COG0395	ABC-type sugar transport system, permease component
NP437_14740	COG1175	transmembrane transport
NP437_14745	COG1653	transport
NP437_14750	COG0371	Dehydrogenase
NP437_14755	COG0647	UMP catabolic process
NP437_14760	COG0235	Class ii aldolase
NP437_14765	COG1069	ribulokinase activity
NP437_14770	COG2160	L-arabinose isomerase activity
NP437_14780	COG1363	Peptidase, m42
NP437_14790	COG3326	Membrane
NP437_14795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NP437_14800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NP437_14805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NP437_14815	COG1346	cytolysis
NP437_14820	COG1380	Effector of murein hydrolase LrgA
NP437_14825	COG3279	Response regulator of the LytR AlgR family
NP437_14830	COG3275	phosphorelay sensor kinase activity
NP437_14835	COG1011	Hydrolase
NP437_14840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP437_14850	COG0398	Pfam SNARE associated Golgi protein
NP437_14855	COG1484	DNA-dependent DNA replication
NP437_14860	COG3611	Membrane attachment protein
NP437_14865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NP437_14870	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NP437_14875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP437_14880	COG1733	regulation of RNA biosynthetic process
NP437_14885	COG2814	Major facilitator Superfamily
NP437_14890	COG0656	L-ascorbic acid biosynthetic process
NP437_14895	COG0237	dephospho-CoA kinase activity
NP437_14905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NP437_14910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP437_14910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP437_14915	COG5002	protein histidine kinase activity
NP437_14920	COG0745	RESPONSE REGULATOR receiver
NP437_14925	COG0039	L-malate dehydrogenase activity
NP437_14930	COG0538	isocitrate dehydrogenase activity
NP437_14935	COG0372	Belongs to the citrate synthase family
NP437_14940	COG2707	UPF0756 membrane protein
NP437_14945	COG0628	permease
NP437_14950	COG3030	protein affecting phage T7 exclusion by the F plasmid
NP437_14955	COG0469	pyruvate kinase activity
NP437_14960	COG0205	6-phosphofructokinase activity
NP437_14965	COG0825	malonyl-CoA metabolic process
NP437_14970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NP437_14975	COG0281	malic enzyme
NP437_14980	COG0587	DNA-directed DNA polymerase activity
NP437_15000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NP437_15010	COG4109	DRTGG domain
NP437_15020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NP437_15025	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_15035	COG0165	Argininosuccinate lyase
NP437_15040	COG0137	argininosuccinate synthase activity
NP437_15045	COG0521	Mo-molybdopterin cofactor biosynthetic process
NP437_15050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NP437_15060	COG0827	DNA restriction-modification system
NP437_15065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NP437_15070	COG3874	Sporulation protein YtfJ
NP437_15080	COG1714	RDD family
NP437_15085	COG0616	signal peptide processing
NP437_15090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP437_15095	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NP437_15100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP437_15110	COG0301	tRNA thio-modification
NP437_15115	COG1104	cysteine desulfurase activity
NP437_15120	COG1114	Component of the transport system for branched-chain amino acids
NP437_15125	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NP437_15130	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP437_15135	COG1309	transcriptional regulator
NP437_15140	COG1956	GAF domain-containing protein
NP437_15145	COG2199	diguanylate cyclase activity
NP437_15145	COG2203	Gaf domain
NP437_15150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NP437_15160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP437_15165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP437_15170	COG0454	-acetyltransferase
NP437_15175	COG0517	IMP dehydrogenase activity
NP437_15180	COG0123	including yeast histone deacetylase and acetoin utilization protein
NP437_15185	COG1360	Flagellar Motor Protein
NP437_15190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP437_15195	COG1609	Transcriptional regulator
NP437_15200	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NP437_15200	COG1605	Chorismate mutase
NP437_15205	COG3118	belongs to the thioredoxin family
NP437_15210	COG4980	gas vesicle protein
NP437_15215	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NP437_15220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP437_15225	COG1674	ftsk spoiiie
NP437_15230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP437_15235	COG4848	Belongs to the UPF0354 family
NP437_15240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP437_15255	COG1363	Peptidase, m42
NP437_15260	COG5584	Small secreted protein
NP437_15265	COG0281	malic enzyme
NP437_15270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP437_15275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NP437_15285	COG0510	thiamine kinase activity
NP437_15290	COG1523	belongs to the glycosyl hydrolase 13 family
NP437_15295	COG1597	lipid kinase activity
NP437_15305	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP437_15310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP437_15315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP437_15320	COG2252	PERMEase
NP437_15325	COG4473	ABC transporter
NP437_15330	COG1131	(ABC) transporter
NP437_15335	COG1349	DNA-binding transcription factor activity
NP437_15340	COG1187	pseudouridine synthase activity
NP437_15345	COG2244	polysaccharide biosynthetic process
NP437_15350	COG2081	HI0933 family
NP437_15355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP437_15375	COG1653	transport
NP437_15380	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NP437_15385	COG4209	transmembrane transport
NP437_15395	COG1653	transport
NP437_15400	COG0395	ABC-type sugar transport system, permease component
NP437_15405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP437_15410	COG2124	cytochrome p450
NP437_15430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP437_15440	COG1073	alpha beta
NP437_15445	COG1609	Transcriptional regulator
NP437_15450	COG1653	transport
NP437_15455	COG1175	transmembrane transport
NP437_15460	COG0395	ABC-type sugar transport system, permease component
NP437_15465	COG1486	melibiose metabolic process
NP437_15470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP437_15475	COG0495	leucyl-tRNA aminoacylation
NP437_15485	COG2202	Pas domain
NP437_15485	COG1366	Belongs to the anti-sigma-factor antagonist family
NP437_15490	COG2814	Major facilitator Superfamily
NP437_15495	COG2433	Pfam Transposase IS66
NP437_15500	COG0577	efflux transmembrane transporter activity
NP437_15505	COG1136	(ABC) transporter
NP437_15510	COG2205	protein histidine kinase activity
NP437_15515	COG0745	RESPONSE REGULATOR receiver
NP437_15520	COG0577	efflux transmembrane transporter activity
NP437_15525	COG1136	(ABC) transporter
NP437_15540	COG1131	(ABC) transporter
NP437_15545	COG1725	Transcriptional regulator
NP437_15560	COG1242	4 iron, 4 sulfur cluster binding
NP437_15565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NP437_15575	COG2267	carboxylic ester hydrolase activity
NP437_15580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NP437_15585	COG1113	amino acid transport
NP437_15590	COG0367	asparagine synthase
NP437_15595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NP437_15600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NP437_15610	COG1506	peptidase
NP437_15615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP437_15620	COG1116	anion transmembrane transporter activity
NP437_15625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP437_15630	COG0494	nUDIX hydrolase
NP437_15635	COG4824	toxin secretion phage lysis holin
NP437_15640	COG0783	Belongs to the Dps family
NP437_15655	COG1854	S-ribosylhomocysteine lyase activity
NP437_15660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NP437_15665	COG0288	reversible hydration of carbon dioxide
NP437_15670	COG0254	rRNA binding
NP437_15675	COG1271	oxidase subunit
NP437_15680	COG1294	oxidase, subunit
NP437_15690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP437_15695	COG1321	iron dependent repressor
NP437_15695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP437_15700	COG1121	(ABC) transporter
NP437_15705	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP437_15710	COG4948	Mandelate Racemase Muconate Lactonizing
NP437_15715	COG0318	PFAM AMP-dependent synthetase and ligase
NP437_15720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NP437_15725	COG0596	Alpha beta hydrolase
NP437_15730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NP437_15735	COG1169	isochorismate synthase
NP437_15740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP437_15745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP437_15750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP437_15755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP437_15760	COG0438	transferase activity, transferring glycosyl groups
NP437_15770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP437_15775	COG0438	transferase activity, transferring glycosyl groups
NP437_15780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP437_15785	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NP437_15790	COG0058	SHG alpha-glucan phosphorylase activity
NP437_15795	COG0297	glycogen (starch) synthase activity
NP437_15800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP437_15805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP437_15810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NP437_15935	COG3859	Proton-coupled thiamine transporter YuaJ
NP437_15940	COG1247	-acetyltransferase
NP437_15945	COG2268	Band 7 protein
NP437_15950	COG1585	Membrane protein implicated in regulation of membrane protease activity
NP437_15955	COG2318	DinB family
NP437_15965	COG1454	alcohol dehydrogenase
NP437_15970	COG1012	belongs to the aldehyde dehydrogenase family
NP437_15975	COG1510	regulation of RNA biosynthetic process
NP437_15985	COG0569	domain protein
NP437_15990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP437_15995	COG4682	membrane
NP437_16000	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP437_16005	COG0477	Major facilitator Superfamily
NP437_16010	COG5553	Cysteine dioxygenase type I
NP437_16020	COG1968	undecaprenyl-diphosphatase activity
NP437_16025	COG0628	permease
NP437_16030	COG0673	inositol 2-dehydrogenase activity
NP437_16035	COG4806	L-rhamnose isomerase
NP437_16040	COG3254	rhamnose metabolic process
NP437_16045	COG1070	Carbohydrate kinase
NP437_16050	COG1349	DNA-binding transcription factor activity
NP437_16055	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_16055	COG3347	Dehydrogenase
NP437_16065	COG0840	transmembrane signaling receptor activity
NP437_16075	COG0840	transmembrane signaling receptor activity
NP437_16090	COG0432	Pfam Uncharacterised protein family UPF0047
NP437_16100	COG0366	Alpha amylase catalytic
NP437_16105	COG1253	flavin adenine dinucleotide binding
NP437_16110	COG2738	Putative neutral zinc metallopeptidase
NP437_16125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NP437_16140	COG0166	Belongs to the GPI family
NP437_16145	COG1979	alcohol dehydrogenase
NP437_16150	COG1979	alcohol dehydrogenase
NP437_16155	COG2155	Conserved Protein
NP437_16160	COG1098	S1 RNA binding domain
NP437_16165	COG0436	Aminotransferase
NP437_16170	COG1522	sequence-specific DNA binding
NP437_16175	COG2267	carboxylic ester hydrolase activity
NP437_16185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NP437_16190	COG2205	protein histidine kinase activity
NP437_16200	COG5018	Exonuclease
NP437_16210	COG2814	Major facilitator Superfamily
NP437_16215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP437_16220	COG3011	Protein conserved in bacteria
NP437_16230	COG3290	protein histidine kinase activity
NP437_16235	COG4565	transcriptional regulatory protein
NP437_16240	COG1744	ABC transporter substrate-binding protein PnrA-like
NP437_16245	COG3845	ABC transporter
NP437_16250	COG4603	Belongs to the binding-protein-dependent transport system permease family
NP437_16255	COG1079	Belongs to the binding-protein-dependent transport system permease family
NP437_16260	COG3493	citrate carrier protein
NP437_16270	COG2111	Na H antiporter
NP437_16270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP437_16275	COG2111	Na H antiporter
NP437_16280	COG1006	Multisubunit Na H antiporter MnhC subunit
NP437_16285	COG0651	ATP synthesis coupled electron transport
NP437_16290	COG1863	multisubunit Na H antiporter MnhE subunit
NP437_16295	COG2212	antiporter activity
NP437_16300	COG1320	monovalent cation:proton antiporter activity
NP437_16305	COG2050	protein possibly involved in aromatic compounds catabolism
NP437_16310	COG2197	response regulator
NP437_16315	COG4585	Histidine kinase
NP437_16335	COG0142	geranyltranstransferase activity
NP437_16355	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NP437_16360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NP437_16365	COG1335	isochorismatase
NP437_16370	COG5506	Protein of unknown function (DUF1694)
NP437_16385	COG0628	permease
NP437_16400	COG1418	mRNA catabolic process
NP437_16405	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_16415	COG1511	domain protein
NP437_16420	COG1674	ftsk spoiiie
NP437_16420	COG0433	COG0433 Predicted ATPase
NP437_16425	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP437_16430	COG5417	Belongs to the EsaB family
NP437_16435	COG4842	Belongs to the WXG100 family
NP437_16440	COG2508	Transcriptional regulator
NP437_16440	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP437_16445	COG0686	Belongs to the AlaDH PNT family
NP437_16450	COG5634	Uncharacterized conserved protein (DUF2278)
NP437_16455	COG3251	PFAM MbtH domain protein
NP437_16460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP437_16465	COG1535	isochorismatase
NP437_16465	COG3433	isochorismatase activity
NP437_16470	COG1021	2,3-dihydroxybenzoate-AMP ligase
NP437_16475	COG1169	isochorismate synthase
NP437_16480	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_16485	COG2819	hydrolase of the alpha beta superfamily
NP437_16490	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP437_16495	COG1268	BioY protein
NP437_16500	COG2056	Na+-H+ antiporter family
NP437_16505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NP437_16510	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NP437_16515	COG3584	3D domain protein
NP437_16530	COG1252	NADH dehydrogenase
NP437_16535	COG0492	ferredoxin-NADP+ reductase activity
NP437_16545	COG0516	GMP reductase activity
NP437_16550	COG2808	Putative FMN-binding domain
NP437_16555	COG0456	acetyltransferase
NP437_16665	COG0582	viral genome integration into host DNA
NP437_16675	COG4974	Belongs to the 'phage' integrase family
NP437_16680	COG0316	Belongs to the HesB IscA family
NP437_16685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NP437_16690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP437_16695	COG4844	belongs to the
NP437_16700	COG1252	NADH dehydrogenase
NP437_16705	COG4837	Protein of unknown function (DUF1462)
NP437_16710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NP437_16715	COG1506	peptidase
NP437_16715	COG4946	Tricorn protease homolog
NP437_16715	COG0823	Involved in the tonB-independent uptake of proteins
NP437_16720	COG0083	homoserine kinase activity
NP437_16725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NP437_16730	COG0460	homoserine dehydrogenase
NP437_16735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP437_16740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP437_16745	COG0647	UMP catabolic process
NP437_16750	COG2445	Protein of unknown function DUF86
NP437_16755	COG4470	Protein conserved in bacteria
NP437_16765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NP437_16770	COG0739	heme binding
NP437_16780	COG3377	Domain of unknown function (DUF1805)
NP437_16785	COG0737	Belongs to the 5'-nucleotidase family
NP437_16790	COG0730	response to heat
NP437_16795	COG1801	Protein of unknown function DUF72
NP437_16805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP437_16810	COG2508	Transcriptional regulator
NP437_16815	COG2233	PERMEase
NP437_16820	COG2233	PERMEase
NP437_16825	COG3195	allantoin biosynthetic process
NP437_16825	COG3648	Uricase
NP437_16830	COG2351	hydroxyisourate hydrolase activity
NP437_16840	COG2080	2 iron, 2 sulfur cluster binding
NP437_16845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NP437_16850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NP437_16855	COG2068	MobA-Related Protein
NP437_16860	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NP437_16865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NP437_16870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP437_16880	COG2356	endonuclease I
NP437_16885	COG3842	ATPase activity
NP437_16890	COG2188	Transcriptional regulator
NP437_16895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP437_16905	COG1175	transmembrane transport
NP437_16910	COG1653	transport
NP437_16915	COG2222	sugar isomerase
NP437_16920	COG0322	excinuclease ABC activity
NP437_16925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP437_16940	COG0346	lactoylglutathione lyase activity
NP437_16945	COG0640	Transcriptional regulator
NP437_16950	COG0719	Fe-S assembly protein
NP437_16955	COG0822	iron-sulfur transferase activity
NP437_16960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP437_16965	COG0719	Fe-S assembly protein
NP437_16970	COG0396	ATPase activity
NP437_16985	COG1464	Belongs to the NlpA lipoprotein family
NP437_16990	COG2011	ABC-type metal ion transport system permease component
NP437_16995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NP437_17005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP437_17010	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP437_17020	COG0509	glycine decarboxylation via glycine cleavage system
NP437_17025	COG1393	Belongs to the ArsC family
NP437_17030	COG1960	acyl-CoA dehydrogenase activity
NP437_17035	COG0183	Belongs to the thiolase family
NP437_17040	COG1024	Enoyl-CoA hydratase
NP437_17040	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP437_17060	COG5577	PFAM Coat F domain
NP437_17065	COG1846	Transcriptional regulator
NP437_17070	COG0477	Major facilitator Superfamily
NP437_17075	COG1942	4-Oxalocrotonate Tautomerase
NP437_17080	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_17085	COG0583	DNA-binding transcription factor activity
NP437_17095	COG1120	ATPase activity
NP437_17120	COG1131	(ABC) transporter
NP437_17165	COG0783	Belongs to the Dps family
NP437_17170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP437_17175	COG0745	RESPONSE REGULATOR receiver
NP437_17180	COG2205	protein histidine kinase activity
NP437_17180	COG2770	Histidine kinase
NP437_17190	COG1309	transcriptional regulator
NP437_17195	COG0114	fumarate hydratase activity
NP437_17205	COG0697	spore germination
NP437_17210	COG0814	amino acid
NP437_17220	COG2197	response regulator
NP437_17225	COG4585	Histidine kinase
NP437_17230	COG4758	membrane
NP437_17235	COG3595	metallopeptidase activity
NP437_17240	COG1842	Phage shock protein A
NP437_17245	COG4758	membrane
NP437_17250	COG2814	Major facilitator Superfamily
NP437_17255	COG2096	Adenosyltransferase
NP437_17260	COG1120	ATPase activity
NP437_17265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP437_17270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP437_17275	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_17280	COG3386	PFAM SMP-30 Gluconolaconase
NP437_17285	COG2205	protein histidine kinase activity
NP437_17290	COG0745	RESPONSE REGULATOR receiver
NP437_17310	COG2140	Oxalate decarboxylase
NP437_17320	COG0577	efflux transmembrane transporter activity
NP437_17325	COG1136	(ABC) transporter
NP437_17330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP437_17335	COG1120	ATPase activity
NP437_17340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP437_17345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP437_17350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP437_17355	COG0531	amino acid
NP437_17365	COG1988	membrane-bound metal-dependent
NP437_17370	COG1368	sulfuric ester hydrolase activity
NP437_17375	COG1910	domain protein
NP437_17380	COG0725	ABC transporter, periplasmic molybdate-binding protein
NP437_17385	COG4149	molybdate abc transporter
NP437_17390	COG0656	L-ascorbic acid biosynthetic process
NP437_17400	COG0025	NhaP-type Na H and K H
NP437_17405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP437_17410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP437_17415	COG3973	AAA domain
NP437_17425	COG2860	membrane
NP437_17430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NP437_17435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP437_17440	COG2217	Heavy metal translocating P-type atpase
NP437_17445	COG2217	Heavy metal translocating P-type atpase
NP437_17450	COG2608	mercury ion transmembrane transporter activity
NP437_17455	COG1937	Protein conserved in bacteria
NP437_17460	COG0673	inositol 2-dehydrogenase activity
NP437_17470	COG1289	transmembrane transporter activity
NP437_17480	COG2076	Multidrug Resistance protein
NP437_17485	COG1309	transcriptional regulator
NP437_17490	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_17500	COG5444	nuclease activity
NP437_17515	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP437_17515	COG3409	Peptidoglycan-binding domain 1 protein
NP437_17520	COG4824	toxin secretion phage lysis holin
NP437_17545	COG3942	CHAP domain
NP437_17545	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP437_17795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NP437_17800	COG0557	exoribonuclease II activity
NP437_17805	COG1647	Serine aminopeptidase, S33
NP437_17810	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP437_17815	COG0596	Alpha beta hydrolase
NP437_17820	COG1476	TRANSCRIPTIONal
NP437_17830	COG1396	sequence-specific DNA binding
NP437_17835	COG1733	regulation of RNA biosynthetic process
NP437_17840	COG0840	transmembrane signaling receptor activity
NP437_17845	COG1174	glycine betaine transport
NP437_17850	COG1732	Glycine betaine
NP437_17855	COG1174	glycine betaine transport
NP437_17860	COG0517	IMP dehydrogenase activity
NP437_17860	COG1125	glycine betaine transport
NP437_17865	COG1510	regulation of RNA biosynthetic process
NP437_17870	COG1174	glycine betaine transport
NP437_17875	COG1732	Glycine betaine
NP437_17880	COG1174	glycine betaine transport
NP437_17885	COG0517	IMP dehydrogenase activity
NP437_17885	COG1125	glycine betaine transport
NP437_17890	COG1510	regulation of RNA biosynthetic process
NP437_17895	COG2095	MarC family integral membrane protein
NP437_17905	COG3064	Membrane
NP437_17910	COG4640	response to antibiotic
NP437_17915	COG0456	acetyltransferase
NP437_17920	COG0148	phosphopyruvate hydratase activity
NP437_17925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NP437_17930	COG0149	triose-phosphate isomerase activity
NP437_17935	COG0126	phosphoglycerate kinase activity
NP437_17940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP437_17945	COG2390	Transcriptional regulator
NP437_17950	COG2814	Major facilitator Superfamily
NP437_17955	COG1609	Transcriptional regulator
NP437_17960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP437_17965	COG0583	DNA-binding transcription factor activity
NP437_17970	COG0697	spore germination
NP437_17975	COG1113	amino acid transport
NP437_17985	COG1556	Lactate utilization protein
NP437_17990	COG1139	Iron-sulfur cluster binding protein
NP437_17995	COG0247	lactate metabolic process
NP437_18000	COG2197	response regulator
NP437_18005	COG4585	Histidine kinase
NP437_18010	COG0842	Transport permease protein
NP437_18015	COG1131	(ABC) transporter
NP437_18035	COG0596	Alpha beta hydrolase
NP437_18040	COG2208	phosphoserine phosphatase activity
NP437_18045	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NP437_18050	COG1874	Beta-galactosidase
NP437_18055	COG3833	ABC-type maltose transport systems, permease component
NP437_18060	COG1175	transmembrane transport
NP437_18065	COG2182	Extracellular solute-binding protein
NP437_18070	COG1609	Transcriptional regulator
NP437_18075	COG2186	Transcriptional regulator
NP437_18080	COG1620	l-lactate permease
NP437_18085	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NP437_18095	COG5039	Polysaccharide pyruvyl transferase
NP437_18100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP437_18105	COG0110	maltose O-acetyltransferase activity
NP437_18110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP437_18115	COG2244	polysaccharide biosynthetic process
NP437_18120	COG1216	Glycosyl transferase, family 2
NP437_18125	COG5039	Polysaccharide pyruvyl transferase
NP437_18130	COG1216	Glycosyl transferase, family 2
NP437_18140	COG0438	transferase activity, transferring glycosyl groups
NP437_18145	COG1215	transferase activity, transferring glycosyl groups
NP437_18150	COG0438	transferase activity, transferring glycosyl groups
NP437_18155	COG1086	Polysaccharide biosynthesis protein
NP437_18160	COG0489	protein tyrosine kinase activity
NP437_18165	COG3944	biosynthesis protein
NP437_18170	COG1396	sequence-specific DNA binding
NP437_18175	COG2272	Belongs to the type-B carboxylesterase lipase family
NP437_18185	COG3479	Phenolic acid decarboxylase
NP437_18200	COG1794	racemase activity, acting on amino acids and derivatives
NP437_18210	COG1621	beta-fructofuranosidase activity
NP437_18215	COG1621	beta-fructofuranosidase activity
NP437_18220	COG0531	amino acid
NP437_18225	COG1309	transcriptional regulator
NP437_18230	COG2076	Multidrug Resistance protein
NP437_18235	COG2076	Multidrug Resistance protein
NP437_18255	COG1674	ftsk spoiiie
NP437_18275	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP437_18275	COG3409	Peptidoglycan-binding domain 1 protein
NP437_18275	COG1388	LysM domain
NP437_18310	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP437_18390	COG0582	viral genome integration into host DNA
NP437_18505	COG4974	Belongs to the 'phage' integrase family
NP437_18515	COG0740	serine-type endopeptidase activity
NP437_18520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP437_18525	COG0366	Alpha amylase catalytic
NP437_18530	COG1554	hydrolase, family 65, central catalytic
NP437_18535	COG5521	maltodextrose utilization protein MalA
NP437_18540	COG3833	ABC-type maltose transport systems, permease component
NP437_18545	COG1175	transmembrane transport
NP437_18550	COG2182	Extracellular solute-binding protein
NP437_18560	COG1609	Transcriptional regulator
NP437_18565	COG1611	Belongs to the LOG family
NP437_18575	COG0659	secondary active sulfate transmembrane transporter activity
NP437_18580	COG0288	reversible hydration of carbon dioxide
NP437_18585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP437_18590	COG0577	efflux transmembrane transporter activity
NP437_18595	COG1136	(ABC) transporter
NP437_18600	COG5002	protein histidine kinase activity
NP437_18605	COG0745	RESPONSE REGULATOR receiver
NP437_18615	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NP437_18620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP437_18625	COG1481	regulation of sporulation
NP437_18630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NP437_18635	COG1660	Displays ATPase and GTPase activities
NP437_18640	COG1051	belongs to the nudix hydrolase family
NP437_18645	COG0492	ferredoxin-NADP+ reductase activity
NP437_18650	COG0791	NLP P60 protein
NP437_18650	COG3883	PFAM NLP P60 protein
NP437_18655	COG0457	Tetratricopeptide repeat
NP437_18660	COG1132	(ABC) transporter
NP437_18680	COG0140	phosphoribosyl-ATP diphosphatase activity
NP437_18680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NP437_18685	COG0107	imidazoleglycerol-phosphate synthase activity
NP437_18690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NP437_18695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NP437_18700	COG0131	Imidazoleglycerol-phosphate dehydratase
NP437_18705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NP437_18710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NP437_18715	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NP437_18720	COG4990	cell redox homeostasis
NP437_18725	COG5297	Belongs to the glycosyl hydrolase family 6
NP437_18740	COG0546	phosphoglycolate phosphatase activity
NP437_18745	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NP437_18750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NP437_18755	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NP437_18760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NP437_18765	COG0363	glucosamine-6-phosphate deaminase activity
NP437_18770	COG2188	Transcriptional regulator
NP437_18775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NP437_18790	COG1950	PFAM Membrane protein of
NP437_18795	COG1983	PspC domain protein
NP437_18800	COG3595	metallopeptidase activity
NP437_18815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP437_18820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NP437_18825	COG0556	nucleotide-excision repair
NP437_18830	COG4897	Protein conserved in bacteria
NP437_18835	COG3848	Pyruvate phosphate dikinase
NP437_18835	COG0574	Belongs to the PEP-utilizing enzyme family
NP437_18840	COG1309	transcriptional regulator
NP437_18845	COG2814	Major facilitator Superfamily
NP437_18850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP437_18860	COG3409	Peptidoglycan-binding domain 1 protein
NP437_18860	COG0793	Belongs to the peptidase S41A family
NP437_18865	COG2177	Part of the ABC transporter FtsEX involved in
NP437_18870	COG2884	Cell division ATP-binding protein ftsE
NP437_18875	COG2010	Cytochrome c
NP437_18880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP437_18890	COG0653	protein targeting
NP437_18895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP437_18910	COG1516	flagellar protein fliS
NP437_18915	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NP437_18920	COG1334	flagellar protein FlaG
NP437_18925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP437_18930	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NP437_18935	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NP437_18945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP437_18950	COG1256	bacterial-type flagellum assembly
NP437_18950	COG4786	Flagellar basal body rod
NP437_18955	COG3418	PFAM FlgN family protein
NP437_18960	COG2747	anti-sigma28 factor FlgM
NP437_18970	COG1040	competence protein
NP437_18980	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NP437_18985	COG1307	EDD domain protein, DegV family
NP437_18990	COG2197	response regulator
NP437_18995	COG4585	Histidine kinase
NP437_19000	COG1739	Uncharacterized protein family UPF0029
NP437_19035	COG1131	(ABC) transporter
NP437_19045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP437_19050	COG0438	transferase activity, transferring glycosyl groups
NP437_19055	COG1215	transferase activity, transferring glycosyl groups
NP437_19060	COG3206	protein involved in exopolysaccharide biosynthesis
NP437_19065	COG3307	-O-antigen
NP437_19070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP437_19075	COG0438	transferase activity, transferring glycosyl groups
NP437_19075	COG0297	glycogen (starch) synthase activity
NP437_19080	COG2244	polysaccharide biosynthetic process
NP437_19095	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP437_19095	COG2247	cell wall binding repeat
NP437_19100	COG2247	cell wall binding repeat
NP437_19100	COG2385	sporulation resulting in formation of a cellular spore
NP437_19130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NP437_19135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP437_19150	COG1682	transport, permease protein
NP437_19160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP437_19160	COG0463	Glycosyl transferase, family 2
NP437_19165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP437_19170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NP437_19175	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NP437_19180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP437_19185	COG4193	domain, Protein
NP437_19190	COG1482	cell wall glycoprotein biosynthetic process
NP437_19195	COG0697	spore germination
NP437_19200	COG0814	amino acid
NP437_19215	COG1316	TRANSCRIPTIONal
NP437_19220	COG0561	phosphatase activity
NP437_19225	COG0791	NLP P60 protein
NP437_19235	COG2843	Capsule synthesis protein
NP437_19245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP437_19250	COG1609	Transcriptional regulator
NP437_19255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP437_19260	COG1869	D-ribose catabolic process
NP437_19265	COG1129	ABC transporter
NP437_19270	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP437_19275	COG1879	ABC-type sugar transport system periplasmic component
NP437_19280	COG3103	Sh3 type 3 domain protein
NP437_19290	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP437_19295	COG3527	Alpha-acetolactate decarboxylase
NP437_19300	COG0028	Belongs to the TPP enzyme family
NP437_19305	COG0583	DNA-binding transcription factor activity
NP437_19310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP437_19325	COG5337	Spore coat protein CotH
NP437_19335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP437_19345	COG0405	Gamma-glutamyltransferase
NP437_19350	COG1522	sequence-specific DNA binding
NP437_19355	COG2059	Chromate
NP437_19360	COG2059	Chromate
NP437_19370	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP437_19375	COG0583	DNA-binding transcription factor activity
NP437_19435	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP437_19440	COG4464	protein tyrosine phosphatase activity
NP437_19445	COG0489	protein tyrosine kinase activity
NP437_19450	COG3944	biosynthesis protein
NP437_19460	COG4715	Zinc finger, swim domain protein
NP437_19465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP437_19470	COG0561	phosphatase activity
NP437_19475	COG1349	DNA-binding transcription factor activity
NP437_19480	COG0629	single-stranded DNA binding
NP437_19505	COG0745	RESPONSE REGULATOR receiver
NP437_19505	COG2972	Histidine kinase
NP437_19510	COG1970	mechanosensitive ion channel activity
NP437_19515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP437_19520	COG0457	Tetratricopeptide repeat
NP437_19525	COG4786	Flagellar basal body rod
NP437_19530	COG4786	Flagellar basal body rod
NP437_19535	COG1077	Cell shape determining protein MreB Mrl
NP437_19540	COG1609	Transcriptional regulator
NP437_19550	COG1846	Transcriptional regulator
NP437_19555	COG2814	Major facilitator Superfamily
NP437_19560	COG3420	alginic acid biosynthetic process
NP437_19565	COG1953	Uracil, thiamine, allantoin
NP437_19570	COG0477	Major facilitator Superfamily
NP437_19575	COG1335	isochorismatase
NP437_19585	COG0004	ammonium transporteR
NP437_19590	COG0347	Belongs to the P(II) protein family
NP437_19595	COG0671	phosphoesterase, PA-phosphatase related
NP437_19605	COG0739	heme binding
NP437_19610	COG1247	-acetyltransferase
NP437_19620	COG2089	acid synthase
NP437_19630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP437_19635	COG0789	Transcriptional regulator
NP437_19645	COG2910	NAD(P)H-binding
NP437_19650	COG1959	2 iron, 2 sulfur cluster binding
NP437_19655	COG0804	urea catabolic process
NP437_19660	COG0832	Belongs to the urease beta subunit family
NP437_19665	COG0831	urea catabolic process
NP437_19680	COG3237	CsbD-like
NP437_19685	COG1994	Peptidase M50
NP437_19690	COG0457	Tetratricopeptide repeat
NP437_19695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NP437_19700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NP437_19710	COG2304	oxidoreductase activity
NP437_19720	COG2304	oxidoreductase activity
NP437_19725	COG2385	sporulation resulting in formation of a cellular spore
NP437_19730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP437_19740	COG4836	Membrane
NP437_19750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NP437_19755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NP437_19760	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NP437_19765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NP437_19770	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP437_19775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NP437_19785	COG0356	it plays a direct role in the translocation of protons across the membrane
NP437_19795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NP437_19800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP437_19805	COG4475	Protein of unknown function (DUF436)
NP437_19810	COG0698	ribose 5-phosphate isomerase
NP437_19815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP437_19820	COG1971	Probably functions as a manganese efflux pump
NP437_19825	COG0009	L-threonylcarbamoyladenylate synthase
NP437_19830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NP437_19850	COG2890	protein-(glutamine-N5) methyltransferase activity
NP437_19855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NP437_19860	COG0346	lactoylglutathione lyase activity
NP437_19865	COG0789	Transcriptional regulator
NP437_19870	COG0679	Auxin Efflux Carrier
NP437_19875	COG0281	malic enzyme
NP437_19880	COG1435	thymidine kinase activity
NP437_19890	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NP437_19900	COG1494	fructose-1,6-bisphosphatase
NP437_19905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP437_19915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NP437_19920	COG0191	fructose-bisphosphate aldolase activity
NP437_19925	COG2204	response regulator
NP437_19930	COG4821	SIS domain
NP437_19935	COG0504	CTP synthase activity
NP437_19940	COG3343	RNA polymerase activity
NP437_19945	COG1960	acyl-CoA dehydrogenase activity
NP437_19950	COG0247	lactate metabolic process
NP437_19950	COG2181	nitrate reductase activity
NP437_19955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP437_19960	COG4294	response to UV
NP437_19970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP437_19980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP437_19990	COG2181	nitrate reductase activity
NP437_19995	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NP437_20000	COG1140	nitrate reductase beta subunit
NP437_20005	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NP437_20010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP437_20020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP437_20025	COG2223	nitrite transmembrane transporter activity
NP437_20030	COG0018	arginyl-trna synthetase
NP437_20035	COG4506	Protein conserved in bacteria
NP437_20050	COG0535	radical SAM domain protein
NP437_20060	COG1131	(ABC) transporter
NP437_20065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP437_20070	COG0612	Peptidase, M16
NP437_20075	COG0612	Peptidase, M16
NP437_20085	COG3391	amine dehydrogenase activity
NP437_20090	COG3391	amine dehydrogenase activity
NP437_20095	COG0457	Tetratricopeptide repeat
NP437_20110	COG0010	Belongs to the arginase family
NP437_20115	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NP437_20120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP437_20135	COG1994	Peptidase M50
NP437_20140	COG1942	4-Oxalocrotonate Tautomerase
NP437_20145	COG1846	Transcriptional regulator
NP437_20150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP437_20155	COG0477	Major facilitator Superfamily
NP437_20160	COG1959	2 iron, 2 sulfur cluster binding
NP437_20165	COG3465	dGTPase activity
NP437_20170	COG1078	dGTPase activity
NP437_20175	COG4844	belongs to the
NP437_20185	COG0697	spore germination
NP437_20190	COG0095	Lipoate-protein ligase
NP437_20195	COG0583	DNA-binding transcription factor activity
NP437_20200	COG0280	phosphate acetyltransferase
NP437_20205	COG3253	May function as heme-dependent peroxidase
NP437_20210	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_20215	COG0436	Aminotransferase
NP437_20220	COG2814	Major facilitator Superfamily
NP437_20225	COG0151	Belongs to the GarS family
NP437_20230	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_20235	COG1917	Cupin 2, conserved barrel domain protein
NP437_20240	COG0077	Prephenate dehydratase
NP437_20245	COG2814	Major facilitator Superfamily
NP437_20250	COG0833	amino acid
NP437_20255	COG4187	Peptidase family M20/M25/M40
NP437_20260	COG1012	belongs to the aldehyde dehydrogenase family
NP437_20265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP437_20275	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NP437_20280	COG1091	dTDP-4-dehydrorhamnose reductase activity
NP437_20285	COG1088	dTDP-glucose 4,6-dehydratase activity
NP437_20290	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NP437_20295	COG3980	spore coat polysaccharide biosynthesis protein
NP437_20300	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NP437_20305	COG2089	acid synthase
NP437_20310	COG0456	acetyltransferase
NP437_20315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP437_20320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP437_20325	COG0463	Glycosyl transferase, family 2
NP437_20335	COG2363	Small membrane protein
NP437_20340	COG2233	PERMEase
NP437_20350	COG1012	belongs to the aldehyde dehydrogenase family
NP437_20355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NP437_20360	COG1216	Glycosyl transferase, family 2
NP437_20365	COG0351	phosphomethylpyrimidine kinase
NP437_20375	COG1621	beta-fructofuranosidase activity
NP437_20380	COG1263	PTS System
NP437_20380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_20385	COG2116	formate transmembrane transporter activity
NP437_20400	COG1404	Belongs to the peptidase S8 family
NP437_20405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP437_20410	COG0778	Nitroreductase
NP437_20415	COG0772	Belongs to the SEDS family
NP437_20430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP437_20435	COG1845	cytochrome c oxidase, subunit III
NP437_20440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP437_20445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP437_20450	COG2261	transglycosylase associated protein
NP437_20455	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NP437_20460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NP437_20465	COG2246	polysaccharide biosynthetic process
NP437_20470	COG1309	transcriptional regulator
NP437_20480	COG3162	membrane
NP437_20485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP437_20490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP437_20495	COG2837	iron assimilation
NP437_20500	COG2822	iron ion transport
NP437_20505	COG0672	)-iron permease
NP437_20510	COG0352	thiamine-phosphate diphosphorylase activity
NP437_20515	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NP437_20520	COG0583	DNA-binding transcription factor activity
NP437_20525	COG1380	Effector of murein hydrolase LrgA
NP437_20530	COG1346	cytolysis
NP437_20535	COG2814	Major facilitator Superfamily
NP437_20540	COG4895	conserved protein (DUF2196)
NP437_20545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NP437_20550	COG0346	lactoylglutathione lyase activity
NP437_20570	COG1263	PTS System
NP437_20570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_20575	COG3711	transcriptional antiterminator
NP437_20580	COG1442	glycosyl transferase family 8
NP437_20585	COG5522	Integral membrane protein (intg_mem_TP0381)
NP437_20590	COG1846	Transcriptional regulator
NP437_20595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP437_20600	COG2234	aminopeptidase activity
NP437_20605	COG2357	RelA SpoT domain protein
NP437_20615	COG1575	Belongs to the MenA family. Type 1 subfamily
NP437_20630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP437_20635	COG1696	Membrane protein involved in D-alanine export
NP437_20640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP437_20645	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NP437_20655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP437_20660	COG1486	melibiose metabolic process
NP437_20665	COG1447	Phosphotransferase system cellobiose-specific component IIA
NP437_20670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP437_20675	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP437_20680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP437_20680	COG3711	transcriptional antiterminator
NP437_20690	COG2094	Belongs to the DNA glycosylase MPG family
NP437_20695	COG0753	catalase activity
NP437_20700	COG2814	Major facilitator Superfamily
NP437_20705	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP437_20710	COG1131	(ABC) transporter
NP437_20730	COG1595	DNA-templated transcription, initiation
NP437_20735	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NP437_20740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NP437_20745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NP437_20750	COG4988	ABC transporter
NP437_20755	COG1294	oxidase, subunit
NP437_20760	COG1271	oxidase subunit
NP437_20765	COG3493	citrate carrier protein
NP437_20770	COG0501	Belongs to the peptidase M48B family
NP437_20780	COG0726	polysaccharide deacetylase
NP437_20785	COG3842	ATPase activity
NP437_20790	COG2508	Transcriptional regulator
NP437_20795	COG1012	belongs to the aldehyde dehydrogenase family
NP437_20800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP437_20805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NP437_20815	COG4585	Histidine kinase
NP437_20820	COG2197	response regulator
NP437_20825	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP437_20840	COG4894	glucomannan catabolic process
NP437_20845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP437_20850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP437_20855	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_20860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP437_20865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP437_20870	COG2610	gluconate transmembrane transporter activity
NP437_20875	COG0500	methyltransferase
NP437_20880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP437_20895	COG0693	protein deglycase activity
NP437_20895	COG0753	catalase activity
NP437_20900	COG2851	Citrate transporter
NP437_20905	COG2273	Hydrolase Family 16
NP437_20910	COG3711	transcriptional antiterminator
NP437_20920	COG2270	Major facilitator Superfamily
NP437_20925	COG0513	Belongs to the DEAD box helicase family
NP437_20930	COG2755	lipolytic protein G-D-S-L family
NP437_20930	COG3401	FG-GAP repeat protein
NP437_21050	COG0697	spore germination
NP437_21065	COG0589	response to stress
NP437_21075	COG1263	PTS System
NP437_21075	COG2190	(PTS) system
NP437_21075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP437_21095	COG5444	nuclease activity
NP437_21115	COG0494	nUDIX hydrolase
NP437_21120	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NP437_21125	COG3507	Belongs to the glycosyl hydrolase 43 family
NP437_21140	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NP437_21145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP437_21150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NP437_21155	COG2390	Transcriptional regulator
NP437_21165	COG3192	ethanolamine utilization protein
NP437_21170	COG2079	MmgE PrpD family protein
NP437_21175	COG1473	amidohydrolase
NP437_21180	COG1126	abc transporter atp-binding protein
NP437_21185	COG0765	amino acid transport
NP437_21190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP437_21195	COG0456	acetyltransferase
NP437_21200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP437_21205	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
NP437_21210	COG0561	phosphatase activity
NP437_21240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP437_21245	COG5294	Protein conserved in bacteria
NP437_21260	COG2205	protein histidine kinase activity
NP437_21265	COG0745	RESPONSE REGULATOR receiver
NP437_21270	COG0191	fructose-bisphosphate aldolase activity
NP437_21275	COG1082	Xylose isomerase domain protein TIM barrel
NP437_21280	COG1082	Xylose isomerase domain protein TIM barrel
NP437_21285	COG0673	inositol 2-dehydrogenase activity
NP437_21290	COG2814	Major facilitator Superfamily
NP437_21295	COG1082	Xylose isomerase domain protein TIM barrel
NP437_21300	COG3962	Belongs to the TPP enzyme family
NP437_21305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP437_21325	COG1349	DNA-binding transcription factor activity
NP437_21330	COG0667	Aldo Keto reductase
NP437_21360	COG0326	Molecular chaperone. Has ATPase activity
NP437_21415	COG1917	Cupin 2, conserved barrel domain protein
NP437_21420	COG1309	transcriptional regulator
NP437_21425	COG1028	Short-chain dehydrogenase reductase Sdr
NP437_21430	COG1846	Transcriptional regulator
NP437_21435	COG1380	Effector of murein hydrolase LrgA
NP437_21440	COG1346	cytolysis
NP437_21445	COG5039	Polysaccharide pyruvyl transferase
NP437_21450	COG1929	Belongs to the glycerate kinase type-1 family
NP437_21455	COG1802	Transcriptional regulator
NP437_21460	COG1070	Carbohydrate kinase
NP437_21465	COG2610	gluconate transmembrane transporter activity
NP437_21470	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP437_21475	COG0450	alkyl hydroperoxide reductase
NP437_21480	COG3634	alkyl hydroperoxide reductase activity
NP437_21485	COG2723	6-phospho-beta-galactosidase activity
NP437_21490	COG2190	(PTS) system
NP437_21500	COG2188	Transcriptional regulator
NP437_21510	COG1131	(ABC) transporter
NP437_21515	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NP437_21525	COG0071	Belongs to the small heat shock protein (HSP20) family
NP437_21555	COG0210	DNA helicase
NP437_21585	COG2963	transposase activity
NP437_21620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NP437_21635	COG1063	alcohol dehydrogenase
NP437_21655	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NP437_21660	COG0456	acetyltransferase
NP437_21665	COG0457	Tetratricopeptide repeat
NP437_21675	COG0010	Belongs to the arginase family
NP437_21680	COG0833	amino acid
NP437_21685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP437_21705	COG5658	integral membrane protein
NP437_21710	COG0640	Transcriptional regulator
NP437_21715	COG3829	transcription factor binding
NP437_21730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP437_21735	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NP437_21740	COG4853	Protein conserved in bacteria
NP437_21745	COG4863	YycH protein
NP437_21750	COG5002	protein histidine kinase activity
NP437_21755	COG0745	RESPONSE REGULATOR receiver
NP437_21785	COG0346	lactoylglutathione lyase activity
NP437_21790	COG0305	Participates in initiation and elongation during chromosome replication
NP437_21805	COG3093	addiction module antidote protein HigA
NP437_21810	COG2807	transmembrane transport
NP437_21815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP437_21820	COG0359	binds to the 23S rRNA
NP437_21825	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NP437_21830	COG4241	membrane
NP437_21845	COG1733	regulation of RNA biosynthetic process
NP437_21850	COG1227	inorganic diphosphatase activity
NP437_21860	COG2271	Major facilitator Superfamily
NP437_21865	COG4978	Transcriptional regulator
NP437_21865	COG0789	Transcriptional regulator
NP437_21875	COG4319	ketosteroid isomerase
NP437_21880	COG1357	PFAM Pentapeptide repeats (8 copies)
NP437_21895	COG1846	Transcriptional regulator
NP437_21900	COG2153	protein acetylation
NP437_21905	COG2364	Membrane
NP437_21910	COG0456	acetyltransferase
NP437_21915	COG2315	Protein conserved in bacteria
NP437_21920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP437_21930	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NP437_21935	COG1331	Highly conserved protein containing a thioredoxin domain
NP437_21940	COG1266	CAAX protease self-immunity
NP437_21945	COG0477	Major facilitator Superfamily
NP437_21945	COG2814	Major facilitator Superfamily
NP437_21950	COG0346	lactoylglutathione lyase activity
NP437_21955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP437_21960	COG0542	response to heat
NP437_21975	COG0708	Exodeoxyribonuclease III
NP437_21980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NP437_21985	COG0629	single-stranded DNA binding
NP437_21990	COG0360	Binds together with S18 to 16S ribosomal RNA
NP437_21995	COG0012	GTP binding
NP437_22000	COG0243	molybdopterin cofactor binding
NP437_22005	COG4481	Protein conserved in bacteria
NP437_22010	COG3949	Membrane
NP437_22020	COG1475	DNA binding
NP437_22025	COG1192	Involved in chromosome partitioning
NP437_22035	COG1475	DNA binding
NP437_22040	COG0357	Ribosomal RNA small subunit methyltransferase G
NP437_22045	COG0445	tRNA wobble uridine modification
NP437_22050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NP437_22055	COG1847	R3H domain protein
NP437_22060	COG0706	membrane insertase activity
NP437_22065	COG0594	ribonuclease P activity
NP437_22265	COG0629	single-stranded DNA binding
NP437_22280	COG0582	viral genome integration into host DNA
NP437_22310	COG1793	dna ligase
NP437_22325	COG1525	nuclease
NP437_22435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP437_22480	COG0457	Tetratricopeptide repeat