locus-tag class description EO946_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EO946_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EO946_00015 ENOG410848D S4 domain protein YaaA EO946_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EO946_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EO946_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EO946_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) EO946_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EO946_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EO946_00100 ENOG4105ZMH deoxynucleoside kinase EO946_00110 ENOG4105VRS hydrolase family 18 EO946_00115 ENOG4105GTG Isochorismatase EO946_00120 ENOG4108Z6B deaminase EO946_00130 ENOG4105C6E dna polymerase iii EO946_00135 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EO946_00140 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EO946_00150 ENOG41067KS pro-sigma K processing EO946_00190 ENOG4105CDW Resistance protein EO946_00195 ENOG4105CXN decarboxylase EO946_00200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EO946_00205 ENOG4105X0R protein from nitrogen regulatory protein P-II EO946_00210 ENOG4105XVJ Protein of unknown function (DUF327) EO946_00215 ENOG4105FA2 dna polymerase iii EO946_00220 ENOG4105MA4 psp1 domain protein EO946_00225 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) EO946_00230 ENOG41060K3 Methyltransferase EO946_00235 ENOG4105VC4 domain protein EO946_00240 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EO946_00245 ENOG4105KRN Transcriptional regulator, abrb family EO946_00250 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EO946_00255 ENOG4105F8V Hydrolase, tatD family EO946_00260 ENOG41069ER domain protein EO946_00270 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EO946_00275 ENOG4105XFA sporulation peptidase YabG EO946_00280 ENOG4105W42 Veg protein EO946_00285 ENOG4105XEW small acid-soluble spore protein EO946_00290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EO946_00295 ENOG4105DFT pur operon repressor EO946_00300 ENOG4105KME endoribonuclease L-psp EO946_00305 ENOG4105K4W Could be involved in septation (By similarity) EO946_00310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EO946_00315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EO946_00320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EO946_00325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EO946_00335 ENOG4108JA2 transcriptioN-repair coupling factor EO946_00340 ENOG4108M14 stage v sporulation protein t EO946_00350 ENOG4108IY2 MazG family EO946_00355 ENOG41082I2 s4 domain protein EO946_00360 ENOG4105VYY sporulation protein yabp EO946_00375 ENOG41060GV RNA binding s1 domain protein EO946_00405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EO946_00410 ENOG4108UGV hypoxanthine phosphoribosyltransferase EO946_00415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EO946_00425 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EO946_00430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase EO946_00435 ENOG4105C6T cysteine synthase EO946_00440 ENOG4105CRQ synthase (Component I) EO946_00445 ENOG4105DDQ anthranilate synthase EO946_00450 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 EO946_00455 ENOG4105EEI dihydropteroate synthase EO946_00460 ENOG4105KRF dihydroneopterin aldolase EO946_00465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EO946_00475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EO946_00480 ENOG4105CRK lysyL-tRNA synthetase EO946_00565 ENOG4108Z0C Uvrb UvrC protein EO946_00570 ENOG41066A3 ATP guanido phosphotransferase EO946_00580 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EO946_00585 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) EO946_00590 ENOG4105CTP PilT protein domain protein EO946_00595 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EO946_00600 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EO946_00605 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EO946_00610 ENOG4105D7W serine acetyltransferase EO946_00615 ENOG4105C8N cysteinyl-tRNA synthetase EO946_00620 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) EO946_00625 ENOG4105C2N RNA methyltransferase TrmH family group 3 EO946_00630 ENOG4105M0M Tetracycline resistance protein EO946_00650 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EO946_00655 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EO946_00665 ENOG4108VZM 50s ribosomal protein L10 EO946_00670 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EO946_00675 ENOG4107Y49 methyltransferase EO946_00680 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EO946_00685 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EO946_00690 ENOG4105XPM ribosomal protein EO946_00695 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EO946_00700 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EO946_00705 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EO946_00710 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EO946_00715 ENOG4107SKW Inherit from COG: Alpha beta hydrolase EO946_00720 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EO946_00725 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EO946_00730 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EO946_00735 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EO946_00740 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EO946_00745 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EO946_00750 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EO946_00755 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EO946_00760 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EO946_00765 ENOG41082SA 50s ribosomal protein l29 EO946_00770 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EO946_00775 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EO946_00785 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EO946_00795 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EO946_00800 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EO946_00805 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EO946_00810 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EO946_00815 ENOG4105VPB 50S ribosomal protein L30 EO946_00820 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EO946_00825 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EO946_00835 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EO946_00845 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EO946_00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EO946_00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EO946_00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EO946_00870 ENOG4108ZT0 50S ribosomal protein l17 EO946_00875 ENOG4108JJB ABC transporter EO946_00880 ENOG4108JJB ABC transporter EO946_00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EO946_00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EO946_00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EO946_00900 ENOG4108UJD 30S ribosomal protein S9 EO946_00910 ENOG4108I0C methyltransferase EO946_00925 ENOG4105D1F ATP-binding protein EO946_00940 ENOG4108NMV polysaccharide deacetylase EO946_01025 ENOG4105CHH sulfate transporter EO946_01035 ENOG4108SA1 esterase EO946_01055 ENOG410874W AraC family transcriptional regulator EO946_01060 ENOG4105EHZ conserved protein UCP016719 EO946_01065 ENOG4105D17 glycoside hydrolase, family 3 domain protein EO946_01085 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EO946_01095 ENOG4105EWC Purine nucleoside phosphorylase EO946_01125 ENOG4105EMN RNA polymerase sigma factor EO946_01135 ENOG4105C8B TIGR00159 family EO946_01140 ENOG4107U5W ybbr family EO946_01145 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EO946_01160 ENOG4108TWJ NADH dehydrogenase subunit 5 EO946_01180 ENOG4105GPN Uncharacterized conserved protein (DUF2294) EO946_01220 ENOG4105E5W Transporter EO946_01230 ENOG4105DTI Phosphonopyruvate decarboxylase EO946_01280 ENOG4105G0J serine threonine protein kinase EO946_01290 ENOG4106K80 EO946_01300 ENOG4106DDH Sporulation-specific SASP protein EO946_01310 ENOG4108HWY Beta-lactamase EO946_01315 ENOG4107E6A Cytochrome p-450 EO946_01330 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EO946_01335 ENOG4105CXY transporter EO946_01350 ENOG410645S MarR family Transcriptional regulator EO946_01355 ENOG4105DCM major facilitator superfamily EO946_01370 ENOG410631K Membrane EO946_01375 ENOG4106AXJ AraC family transcriptional regulator EO946_01380 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR EO946_01385 ENOG4108TCS Glutamyl endopeptidase EO946_01395 ENOG4108WC5 Alpha Beta Hydrolase Fold protein EO946_01400 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EO946_01405 ENOG4107ZTW SNARE associated Golgi EO946_01425 ENOG4105C72 UPF0176 protein EO946_01440 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EO946_01445 ENOG4108X79 transcriptional regulator EO946_01460 ENOG4105CM2 brancheD-chain amino acid aminotransferase EO946_01465 ENOG4108IQI permease EO946_01470 ENOG4108J5H Homocysteine s-methyltransferase EO946_01485 ENOG4105CSV Glutaminase EO946_01500 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase EO946_01505 ENOG4105C26 Dehydrogenase EO946_01510 ENOG4105DJB Major Facilitator Superfamily EO946_01515 ENOG4105EQX glucarate dehydratase EO946_01520 ENOG41073TP transcriptional regulator EO946_01525 ENOG4105CTX dehydratase EO946_01540 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EO946_01575 ENOG4105MUA Resistance protein EO946_01585 ENOG4105DGI Alkaline phosphatase EO946_01590 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EO946_01595 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EO946_01600 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EO946_01605 ENOG4107EPV Aminotransferase class V EO946_01610 ENOG4105C0R drug resistance transporter emrb qaca subfamily EO946_01615 ENOG4105J7D transcriptional regulator EO946_01620 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold EO946_01630 ENOG41060AI SEC-C motif EO946_01645 ENOG4107SET aldo keto reductase EO946_01695 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EO946_01705 ENOG4105DSE periplasmic solute binding protein EO946_01710 ENOG4105DIK (ABC) transporter EO946_01720 ENOG4105DEN Luciferase family EO946_01725 ENOG4108N0M stress protein EO946_01730 ENOG4106FN3 tellurium resistance protein EO946_01735 ENOG4106FN3 tellurium resistance protein EO946_01740 ENOG4107TS3 membrane protein, TerC EO946_01745 ENOG4108TTB tellurium resistance protein EO946_01755 ENOG41079KZ Major Facilitator Superfamily EO946_01760 ENOG4107XZQ multidrug resistance protein EO946_01765 ENOG4108A65 Transcriptional regulator EO946_01770 ENOG4108IJ7 Glycine betaine EO946_01775 ENOG4107SQ8 Glycine betaine EO946_01805 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EO946_01840 ENOG4105EIG urea carboxylase-associated protein 1 EO946_01845 ENOG4107RA1 nh(3)-dependent nad( ) synthetase EO946_01850 ENOG4105I1F Resistance protein EO946_01855 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EO946_01860 ENOG41089UC methyltransferase, type 11 EO946_01865 ENOG4105C5Q Transcriptional regulator EO946_01870 ENOG4105I82 acetyl xylan esterase EO946_01875 ENOG410756H nucleotidyltransferase EO946_01885 ENOG4105C26 Dehydrogenase EO946_01890 ENOG4105CK7 Sodium proline symporter EO946_01895 ENOG4107YHD transcriptional regulator EO946_01905 ENOG4108PJD permease EO946_01910 ENOG4105U6C Alpha beta hydrolase fold protein EO946_01920 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EO946_01925 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EO946_01930 ENOG4108IFG nitrite reductase, (NAD(P)H) EO946_01935 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EO946_01955 ENOG4105S7A ErfK ybiS ycfS ynhG family protein EO946_01955 ENOG4105S7A ErfK ybiS ycfS ynhG family protein EO946_01965 ENOG4105CKI cobalamin synthesis protein EO946_01970 ENOG4105E5Q amino acid AbC transporter EO946_01975 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein EO946_01980 ENOG4105HHM rdd domain containing protein EO946_01990 ENOG4105K56 Transcriptional regulator EO946_02000 ENOG4108VEN abc transporter atp-binding protein EO946_02005 ENOG4105CS2 ec 3.2.1.21 EO946_02020 ENOG4105C8Q Methyl-accepting chemotaxis EO946_02025 ENOG41080HJ 6-phospho 3-hexuloisomerase EO946_02030 ENOG4108VA3 3-hexulose-6-phosphate synthase EO946_02035 ENOG4105KVH Transcriptional regulator EO946_02040 ENOG4105CEY Amp-dependent synthetase and ligase EO946_02070 ENOG4105SX7 Transporter EO946_02080 ENOG4105W8Z 4'-phosphopantetheinyl transferase EO946_02090 ENOG4105CDA abc transporter atp-binding protein EO946_02095 ENOG4105DRP amino acid AbC transporter EO946_02105 ENOG4106P55 Transcriptional regulator EO946_02110 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EO946_02115 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EO946_02120 ENOG41069ZX EO946_02125 ENOG41069ZX EO946_02135 ENOG4105DUX Transporter EO946_02150 ENOG4105E1K spore germination protein EO946_02170 ENOG4107WD8 ABC transporter, permease EO946_02175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EO946_02180 ENOG4105BZU Histidine kinase EO946_02200 ENOG4105CFH Aspartokinase EO946_02205 ENOG4105DHS permease protein EO946_02210 ENOG4105CM4 permease protein EO946_02215 ENOG4108IPW abc transporter atp-binding protein EO946_02230 ENOG4105R8C Transcriptional regulator EO946_02235 ENOG4108DBC nitroreductase EO946_02240 ENOG41067V3 Antibiotic biosynthesis monooxygenase EO946_02245 ENOG4105YVS arsR family transcriptional regulator EO946_02255 ENOG4108JPW Aminotransferase EO946_02260 ENOG4105C26 Dehydrogenase EO946_02270 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EO946_02275 ENOG4105KTB nuclear export factor GLE1 EO946_02280 ENOG4108T5E Copper resistance protein EO946_02285 ENOG4108ZYE Transcriptional regulator EO946_02310 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EO946_02315 ENOG4108ZX0 Signal peptidase I EO946_02340 ENOG4105E7W lamb ycsf family protein EO946_02345 ENOG4105C5A transporter EO946_02350 ENOG4105CFM UPF0317 protein EO946_02355 ENOG4105P4J Allophanate hydrolase, subunit 1 EO946_02365 ENOG4107258 Transcriptional regulator EO946_02370 ENOG4105XJB lipolytic protein G-D-S-L family EO946_02380 ENOG41061CK Antibiotic biosynthesis monooxygenase EO946_02385 ENOG4107RVG penicillin-binding protein EO946_02390 ENOG4107QM2 Aldo Keto reductase EO946_02395 ENOG4105ETD TRANSCRIPTIONal EO946_02405 ENOG4105HMZ Methyltransferase EO946_02410 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EO946_02425 ENOG410606W general stress protein EO946_02435 ENOG4105VCH membrane EO946_02445 ENOG4105C9U ATP-dependent DNA helicase RecQ EO946_02460 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) EO946_02465 ENOG4107R8N Glycosyl transferase, family 2 EO946_02475 ENOG4105C0X amino acid EO946_02495 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EO946_02500 ENOG4107BMA Transglycosylase associated protein EO946_02505 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) EO946_02510 ENOG4105EU9 EO946_02515 ENOG4105QVS general stress protein EO946_02535 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EO946_02540 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EO946_02545 ENOG4108MRH transcriptional regulatory protein EO946_02550 ENOG4107QJT sodium dicarboxylate symporter EO946_02555 ENOG4106F5Q Membrane EO946_02565 ENOG4105CJ1 ABC, transporter EO946_02580 ENOG4105FDT acyl-CoA dehydrogenase EO946_02600 ENOG4105SZ6 Thioredoxin EO946_02605 ENOG4105CPF Cell wall formation (By similarity) EO946_02610 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EO946_02620 ENOG4105C1J atp-dependent rna helicase EO946_02625 ENOG410905X membrane-flanked domain protein EO946_02630 ENOG4105CKV Membrane EO946_02640 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) EO946_02645 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein EO946_02650 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EO946_02660 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EO946_02665 ENOG4107MMM Anti-sigma-factor antagonist EO946_02670 ENOG4105FUA antagonist EO946_02675 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase EO946_02680 ENOG4107SGM protein serine threonine phosphatase EO946_02685 ENOG4105WN5 stage II sporulation protein EO946_02690 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EO946_02700 ENOG41064BQ Phosphatase EO946_02760 ENOG4105VUF Transcriptional regulator EO946_02765 ENOG4105E1F short-chain dehydrogenase reductase EO946_02770 ENOG4107SET aldo keto reductase EO946_02775 ENOG4105EMU Dehydrogenase EO946_02780 ENOG4105DTD Dehydrogenase EO946_02790 ENOG4105EMU Dehydrogenase EO946_02795 ENOG4105ECK Fatty Acid Desaturase EO946_02805 ENOG4105VEQ Cold shock protein EO946_02810 ENOG4108VJ1 Transcriptional regulator (CarD family EO946_02820 ENOG4108IMY Transcriptional regulator EO946_02825 ENOG41086D8 Transcriptional regulator EO946_02835 ENOG4105CZ9 Domain of unknown function (DU1801) EO946_02840 ENOG4105GIG EO946_02850 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein EO946_02860 ENOG4105T38 integral membrane protein EO946_02865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EO946_02870 ENOG4108ZMQ domain protein EO946_02875 ENOG4105MJ9 esterase EO946_02880 ENOG4107Z6X Transcriptional regulator EO946_02895 ENOG41082YX Transcriptional regulator, arsr family EO946_02900 ENOG4107R5R arsenical pump membrane protein EO946_02905 ENOG4108UXE Protein tyrosine phosphatase EO946_02910 ENOG4105Z7P Acetyltransferase (GNAT) family EO946_02915 ENOG4107Y9U Membrane EO946_02925 ENOG4108SQ9 flavin reductase domain protein, FMN-binding EO946_02930 ENOG4108ZHR arsR family transcriptional regulator EO946_02935 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EO946_02950 ENOG4105ENE Histidine kinase EO946_02955 ENOG4108VB1 regulatoR EO946_02960 ENOG4105EYF MMPL domain protein EO946_02985 ENOG4108UQV Membrane EO946_02990 ENOG4108Z5V transcriptional regulator, merr family EO946_02995 ENOG41076HS cation diffusion facilitator family transporter EO946_03000 ENOG4108TVJ Nitroreductase EO946_03005 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EO946_03010 ENOG4108VGI doxx family EO946_03015 ENOG4105XXY Thioredoxin EO946_03020 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EO946_03035 ENOG4108VQJ O-methyltransferase EO946_03040 ENOG410900G Protein of unknown function (DUF421) EO946_03060 ENOG4105PF9 Transcriptional regulator EO946_03070 ENOG4105WQG acetyltransferase EO946_03080 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EO946_03085 ENOG4105ETE Transcriptional regulator (LacI family EO946_03095 ENOG4107TRE AP endonuclease, family 2 EO946_03100 ENOG4105F27 Major Facilitator EO946_03115 ENOG4105C85 amino acid EO946_03125 ENOG41062A4 Transcriptional regulator EO946_03130 ENOG4105EYF MMPL domain protein EO946_03135 ENOG4108TVJ Nitroreductase EO946_03140 ENOG4105FS7 Transcriptional regulator EO946_03145 ENOG4108JCI Transcriptional regulator EO946_03160 ENOG4105C2C drug resistance transporter, Bcr CflA EO946_03170 ENOG4105DRR Transcriptional regulator, GntR family EO946_03175 ENOG4105VRS hydrolase family 18 EO946_03195 ENOG4105G6Z alkaline phosphatase EO946_03210 ENOG4107TVP HD domain protein EO946_03215 ENOG41090UD (LipO)protein EO946_03220 ENOG4105F27 Major Facilitator EO946_03225 ENOG4105VZJ PTS System EO946_03230 ENOG4105VCP PTS System EO946_03235 ENOG4105CK1 PTS System EO946_03240 ENOG4105CS2 ec 3.2.1.21 EO946_03245 ENOG4108TZY GntR Family Transcriptional Regulator EO946_03250 ENOG4105EVU fructokinase EO946_03255 ENOG4105DG6 mannose-6-phosphate isomerase EO946_03260 ENOG4105D3P Mannan endo-1,4-beta-mannosidase EO946_03305 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EO946_03310 ENOG4105K8N protein family UPF0079, ATPase EO946_03315 ENOG41072GX Peptidase M22 Glycoprotease EO946_03320 ENOG410801F ribosomal-protein-alanine acetyltransferase EO946_03325 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EO946_03330 ENOG4105C5H ABC transporter EO946_03335 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EO946_03340 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) EO946_03345 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EO946_03350 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EO946_03360 ENOG4108TYN CAAX amino terminal protease family protein EO946_03365 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EO946_03370 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EO946_03385 ENOG4105PGZ NB-ARC domain EO946_03390 ENOG4105CPQ Dehydrogenase EO946_03395 ENOG4105CT4 transporter EO946_03405 ENOG41087YS Phage shock protein A EO946_03410 ENOG4105DQX Zinc finger domain EO946_03415 ENOG4108WV1 Pfam:DUF477 EO946_03425 ENOG4108ZMR Ion transport 2 domain-containing protein EO946_03430 ENOG4107QNK )-transporter EO946_03465 ENOG4107YUH hydrolase EO946_03475 ENOG4107STQ Multicopper oxidase EO946_03480 ENOG4105C85 amino acid EO946_03495 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EO946_03515 ENOG4105C7N Xanthine uracil vitamin C permease EO946_03540 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EO946_03545 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EO946_03550 ENOG4105C83 adenylosuccinate lyase EO946_03555 ENOG4105C8V SAICAR synthetase EO946_03560 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EO946_03565 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EO946_03570 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EO946_03580 ENOG4105CXB phosphoribosylaminoimidazole synthetase EO946_03585 ENOG4108V3E phosphoribosylglycinamide formyltransferase EO946_03590 ENOG4105DC1 bifunctional purine biosynthesis protein purh EO946_03595 ENOG4105C12 Phosphoribosylglycinamide synthetase EO946_03605 ENOG4105DVH amino acid EO946_03620 ENOG4108R5T secreted protein EO946_03625 ENOG4105KGF protein, YerC YecD EO946_03630 ENOG4105CBC glutamate synthase EO946_03635 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) EO946_03640 ENOG4105C4R Atp-dependent dna helicase EO946_03645 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EO946_03655 ENOG4105CRN Aminoglycoside phosphotransferase EO946_03660 ENOG4105KT7 mgtC SapB transporter EO946_03665 ENOG4105CK7 Sodium proline symporter EO946_03670 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EO946_03675 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EO946_03680 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EO946_03685 ENOG4108IG5 Transcriptional regulator EO946_03695 ENOG4105CBD Diacylglycerol kinase EO946_03700 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EO946_03705 ENOG4105CVR type I restriction-modification system EO946_03710 ENOG41082EK Restriction modification system DNA (Specificity EO946_03715 ENOG4105DZR Type I site-specific deoxyribonuclease EO946_03755 ENOG4105CDY transcriptional regulatory protein EO946_03765 ENOG4105M4P Tetr family transcriptional regulator EO946_03770 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein EO946_03775 ENOG4107S9F NmrA family EO946_03780 ENOG4105KHM amidohydrolase 2 EO946_03785 ENOG4105ST3 Transcriptional regulator EO946_03800 ENOG4105WEF catalase EO946_03805 ENOG4105M18 -acetyltransferase EO946_03820 ENOG4105C2F Histidine kinase EO946_03825 ENOG4105EQD regulatoR EO946_03830 ENOG410769Z extracellular solute-binding protein family 1 EO946_03835 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EO946_03840 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EO946_03845 ENOG4105F5H Glycosyl Hydrolase Family 88 EO946_03850 ENOG41075H3 AraC family transcriptional regulator EO946_03855 ENOG4107TDE lipolytic protein G-D-S-L family EO946_03870 ENOG4105CX8 fg-gap repeat protein EO946_03875 ENOG4105CX8 fg-gap repeat protein EO946_03880 ENOG4107TDE lipolytic protein G-D-S-L family EO946_03890 ENOG4105EKC EO946_03895 ENOG4105E0S extracellular solute-binding protein family 1 EO946_03905 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EO946_03910 ENOG4105F8D glycoside hydrolase family 4 EO946_03915 ENOG4105H67 Protein of unknown function (DUF421) EO946_03920 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) EO946_03925 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily EO946_03945 ENOG4106I4J membrane EO946_03950 ENOG41082F9 transcriptional regulator EO946_03955 ENOG41061H0 Monooxygenase EO946_03960 ENOG4108R1P EO946_03965 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EO946_03970 ENOG4105E0M Sulfatase EO946_03975 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EO946_03985 ENOG41090R9 glycosyltransferase EO946_03990 ENOG4107R51 Glycosyl transferase, family 2 EO946_03995 ENOG41090R9 glycosyltransferase EO946_04000 ENOG4105EU0 Major facilitator Superfamily EO946_04010 ENOG4105CUB amino acid EO946_04015 ENOG4105C26 Dehydrogenase EO946_04020 ENOG4105FKZ Methyl-accepting chemotaxis EO946_04025 ENOG4105C5H ABC transporter EO946_04035 ENOG4107SWG transcriptional regulator MERR family EO946_04040 ENOG4105DXB Major Facilitator superfamily EO946_04050 ENOG4105C5H ABC transporter EO946_04055 ENOG4105FDU atp-dependent rna helicase EO946_04065 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EO946_04070 ENOG4105E0A ABC, transporter EO946_04075 ENOG4108U1V ABC transporter, permease EO946_04080 ENOG4105DQ5 transport system permease protein EO946_04085 ENOG4108HUF Transporter EO946_04100 ENOG4108J20 pectate lyase EO946_04105 ENOG4107QPK )-transporter EO946_04115 ENOG4108MRH transcriptional regulatory protein EO946_04140 ENOG410855V Acylphosphatase EO946_04145 ENOG4108RPX mosc domain containing protein EO946_04165 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) EO946_04195 ENOG4105GEU Spore germination protein EO946_04205 ENOG4108Q5U germination protein, ger(x)c family EO946_04210 ENOG4105E1K spore germination protein EO946_04215 ENOG4105C5Y PTS System EO946_04220 ENOG4105CG3 alpha amylase, catalytic region EO946_04225 ENOG4107414 GntR family transcriptional regulator EO946_04230 ENOG4108RCM Nitroreductase EO946_04235 ENOG4105CGH 5'-nucleotidase EO946_04240 ENOG4107RKG DJ-1/PfpI family EO946_04255 ENOG4105KJF protein tyrosine phosphatase EO946_04265 ENOG4107U9T Pfam:Ribonuclease_BN EO946_04270 ENOG4108ISG Major Facilitator EO946_04275 ENOG4105UPD Calcium Proton EO946_04285 ENOG4105D8X mechanosensitive ion channel EO946_04305 ENOG4106KE4 Dehydrogenase EO946_04310 ENOG4105D7N magnesium and cobalt transport protein CorA EO946_04325 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EO946_04335 ENOG4105KNA -acetyltransferase EO946_04350 ENOG4107RUY (E1 component), alpha subunit EO946_04360 ENOG4107QKR Dehydrogenase EO946_04370 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EO946_04375 ENOG41069DP small acid-soluble spore protein EO946_04380 ENOG4105KK4 UPF0060 membrane protein EO946_04405 ENOG4105F8D glycoside hydrolase family 4 EO946_04410 ENOG4108Q3X Transcriptional regulator EO946_04415 ENOG4105CI1 PTS System EO946_04420 ENOG4105BZ1 (ABC) transporter EO946_04425 ENOG4105BZ1 (ABC) transporter EO946_04435 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EO946_04440 ENOG4105BZU Histidine kinase EO946_04445 ENOG4105WH1 Two component transcriptional regulator luxr family EO946_04450 ENOG4105CJ1 ABC, transporter EO946_04455 ENOG41090VJ ABC-2 type transporter EO946_04460 ENOG4108KYE ABC-2 type transporter EO946_04470 ENOG4105U3E Transcriptional regulator EO946_04475 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold EO946_04480 ENOG4105H93 Acyltransferase family EO946_04485 ENOG4108YYS metal-dependent hydrolase (By similarity) EO946_04490 ENOG4105C0R drug resistance transporter emrb qaca subfamily EO946_04495 ENOG410834F Transcriptional regulator EO946_04505 ENOG4108MES Periplasmic binding protein EO946_04510 ENOG4105DQ5 transport system permease protein EO946_04515 ENOG4108IHU transport system permease protein EO946_04525 ENOG4107Y03 Nitroreductase EO946_04540 ENOG4105ECP epimerase EO946_04560 ENOG4105F27 Major Facilitator EO946_04580 ENOG4106AKJ EO946_04585 ENOG4105D74 hydrolase EO946_04590 ENOG4105CKK Glycosyl transferase, family 2 EO946_04595 ENOG4105EJV Membrane EO946_04600 ENOG41067AE Membrane-bound metal-dependent hydrolase EO946_04605 ENOG4105CEN a g-specific adenine glycosylase EO946_04610 ENOG4106BXE EO946_04615 ENOG4105CAN Short-chain dehydrogenase reductase Sdr EO946_04630 ENOG4105EVI UPF0374 protein EO946_04635 ENOG4105BZ1 (ABC) transporter EO946_04640 ENOG4107NBY Membrane EO946_04650 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EO946_04655 ENOG4105G5W regulator Fur family EO946_04765 ENOG4108N23 SpoOM-related protein EO946_04780 ENOG4105EC3 peptidase S51, dipeptidase E EO946_04785 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EO946_04800 ENOG4105E2Y ABC, transporter EO946_04805 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EO946_04810 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EO946_04815 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EO946_04825 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EO946_04830 ENOG4107D63 EO946_04835 ENOG4105VZ8 Transcriptional regulator EO946_04850 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EO946_04860 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EO946_04880 ENOG4105CYN Serine protein kinase EO946_04885 ENOG4106AKX UPF0229 protein EO946_04890 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EO946_04895 ENOG4105CW7 secretion protein, HlyD family EO946_04900 ENOG4105C0R drug resistance transporter emrb qaca subfamily EO946_04905 ENOG4105CS1 NAD(P)H quinone oxidoreductase EO946_04920 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EO946_04925 ENOG4105CZV ABC transporter EO946_04930 ENOG4105CJ1 ABC, transporter EO946_04940 ENOG4105VEQ Cold shock protein EO946_04955 ENOG4105BZU Histidine kinase EO946_04995 ENOG4108YBP pseudouridine synthase EO946_05005 ENOG41080XP Cbs domain EO946_05010 ENOG4107YBY Hydrolase EO946_05015 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EO946_05025 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EO946_05030 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EO946_05040 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EO946_05045 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EO946_05055 ENOG4105BZU Histidine kinase EO946_05060 ENOG4105WH1 Two component transcriptional regulator luxr family EO946_05095 ENOG4105ED1 spovr family EO946_05100 ENOG4105G6Z alkaline phosphatase EO946_05115 ENOG4105BZN citrate synthase EO946_05120 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EO946_05125 ENOG4105CUB amino acid EO946_05130 ENOG4105C8J )-transporter EO946_05135 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EO946_05150 ENOG4105J37 EO946_05155 ENOG4108AEY RNA polymerase sigma factor EO946_05160 ENOG4108FN7 Aldo keto reductase EO946_05165 ENOG4105F6E Acyl-transferase EO946_05170 ENOG4107VFR oxidoreductase EO946_05180 ENOG4105C37 (CBS) domain EO946_05190 ENOG4105CHM Aminotransferase EO946_05195 ENOG4105C37 (CBS) domain EO946_05205 ENOG4105WMR Protein CrcB homolog EO946_05210 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EO946_05220 ENOG4105D64 Mechanosensitive ion channel EO946_05225 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EO946_05230 ENOG4107VMI polysaccharide deacetylase EO946_05235 ENOG4105F0I Aminotransferase EO946_05255 ENOG4105BZ1 (ABC) transporter EO946_05260 ENOG4105BZ1 (ABC) transporter EO946_05290 ENOG410839P EO946_05300 ENOG4106MP8 UPF0754 membrane protein EO946_05305 ENOG4105WZB UPF0342 protein EO946_05310 ENOG4105F1N DNA alkylation repair EO946_05320 ENOG4105D4P Coproporphyrinogen iii oxidase EO946_05325 ENOG4107S91 Sodium hydrogen exchanger EO946_05330 ENOG4105NCW Trka-c domain protein EO946_05340 ENOG4105CGU Enoyl-CoA hydratase EO946_05350 ENOG4108IUX (ABC) transporter EO946_05355 ENOG4105RHA ABC transporter, permease EO946_05360 ENOG4107VRP DNA repair exonuclease EO946_05365 ENOG4106D4I domain protein EO946_05370 ENOG4105EQI Metal Dependent Phosphohydrolase EO946_05380 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EO946_05425 ENOG4105NBU tryptophan transport protein EO946_05430 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EO946_05435 ENOG4105K59 histidine triad (HIT) protein EO946_05470 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation EO946_05475 ENOG4105BZ4 penicillin-binding protein EO946_05480 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EO946_05485 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EO946_05490 ENOG4105C1Q protoporphyrinogen oxidase EO946_05500 ENOG4105ECB domain protein EO946_05510 ENOG41090T1 Membrane EO946_05520 ENOG4105DER m42 family EO946_05535 ENOG4106AXD EO946_05540 ENOG4108RQ5 Beta-lactamase domain-containing protein EO946_05545 ENOG4105DF9 Lipoate-protein, ligase EO946_05555 ENOG4105CEY Amp-dependent synthetase and ligase EO946_05565 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 EO946_05575 ENOG4105KD7 acetyltransferase EO946_05585 ENOG4108HUF Transporter EO946_05590 ENOG4107TB6 phosphoglycerate mutase EO946_05600 ENOG4107F3J Amp-dependent synthetase and ligase EO946_05605 ENOG4107ZYJ bioY protein EO946_05610 ENOG4106YBV Methyl-accepting chemotaxis EO946_05630 ENOG4105XVF Competence transcription factor EO946_05635 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EO946_05640 ENOG4105X3H Excalibur domain protein EO946_05645 ENOG4105E1V na solute symporter EO946_05650 ENOG4106CAD Protein of unknown function (DUF3311) EO946_05655 ENOG41060YP EO946_05670 ENOG4107SCK Monooxygenase EO946_05675 ENOG4108INS Transcriptional regulator EO946_05695 ENOG4105TRI Hydrolase EO946_05710 ENOG4108KK1 membrane protein AbrB duplication EO946_05715 ENOG4106K7D Major facilitator family transporter EO946_05720 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) EO946_05725 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding EO946_05740 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EO946_05750 ENOG4105EYH Exonuclease EO946_05800 ENOG4105ERH Fumarylacetoacetate hydrolase EO946_05810 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EO946_05820 ENOG4105CAQ asparagine synthetase EO946_05835 ENOG4105UQX Mate efflux family protein EO946_05840 ENOG4106HBX Transcriptional Regulator AraC Family EO946_05845 ENOG4105ETE Transcriptional regulator (LacI family EO946_05850 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EO946_05855 ENOG4105SF0 DinB family EO946_05860 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EO946_05865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EO946_05870 ENOG4105MYW Pentapeptide repeat protein EO946_05875 ENOG4107S9D Alpha beta hydrolase EO946_05880 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) EO946_05885 ENOG4107RIQ Sulfate adenylate transferase EO946_05890 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EO946_05895 ENOG4108N5B 2-phosphosulfolactate phosphatase EO946_05900 ENOG41061P3 phosphosulfolactate synthase EO946_05910 ENOG4105DIA mandelate racemase muconate lactonizing EO946_05915 ENOG4107RCC Major Facilitator Superfamily EO946_05920 ENOG4108SZE gCN5-related N-acetyltransferase EO946_05925 ENOG4105MA6 gCN5-related N-acetyltransferase EO946_05935 ENOG4108VPT UPF0234 protein EO946_05940 ENOG4105QNR S1 RNA binding domain protein EO946_05945 ENOG410751J EO946_05950 ENOG4105EPR degv family EO946_05955 ENOG4107AYK membrAne EO946_05965 ENOG41073B9 EO946_05970 ENOG4108KP7 hydrolase EO946_05975 ENOG4108MXZ Esterase EO946_05980 ENOG4105VG1 fes assembly suf system protein EO946_05990 ENOG4105IQ5 FAD linked oxidase domain protein EO946_06000 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EO946_06015 ENOG4105C8Y Acetylornithine aminotransferase EO946_06020 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EO946_06030 ENOG4105DBV ornithine carbamoyltransferase EO946_06055 ENOG4107RMD Basic membrane lipoprotein EO946_06070 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EO946_06075 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EO946_06085 ENOG4105C3U ABC transporter EO946_06090 ENOG4108JQ7 (ABC) transporter EO946_06105 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EO946_06115 ENOG4105C31 Tryptophanyl-tRNA synthetase EO946_06125 ENOG4108J59 Extracellular solute-binding protein, family 5 EO946_06130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EO946_06135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EO946_06145 ENOG4108JQ7 (ABC) transporter EO946_06160 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) EO946_06165 ENOG4108ZCF integral membrane protein EO946_06175 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis EO946_06190 ENOG4105DPN Oligoendopeptidase f EO946_06205 ENOG4105T58 Dithiol-disulfide isomerase EO946_06210 ENOG4108Z18 K06886 hemoglobin EO946_06215 ENOG4105E4C Lytic transglycosylase catalytic EO946_06220 ENOG4105MIX Adenylate cyclase EO946_06235 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EO946_06240 ENOG4105EMS pseudouridine synthase EO946_06255 ENOG4105ETU transcriptional activator (TenA EO946_06260 ENOG4108VEU Thiamine monophosphate synthase EO946_06275 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EO946_06280 ENOG4105D06 uba thif-type nad fad binding protein EO946_06285 ENOG4105DWF phosphomethylpyrimidine kinase EO946_06290 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EO946_06295 ENOG4107A88 EO946_06345 ENOG4105ENA helicase EO946_06360 ENOG4108ZMI UPF0477 protein EO946_06370 ENOG4105C28 cystathionine EO946_06375 ENOG4105C28 cystathionine EO946_06385 ENOG4105JHY Membrane EO946_06445 ENOG4105DM4 PTS System EO946_06450 ENOG4105DG6 mannose-6-phosphate isomerase EO946_06470 ENOG4108Z66 YbaK ebsC protein EO946_06485 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EO946_06495 ENOG4108ZJ4 polysaccharide deacetylase EO946_06500 ENOG4107CUJ Protein of unknown function (DUF2690) EO946_06525 ENOG4108IEG Formate dehydrogenase Alpha subunit EO946_06550 ENOG4106A3M Cytochrome p-450 EO946_06555 ENOG41087PP glycosyltransferase MGT family EO946_06565 ENOG4105EXQ uroporphyrinogen iii synthase hem4 EO946_06570 ENOG4105C4B ABC transporter, permease EO946_06575 ENOG4108IXI (ABC) transporter EO946_06585 ENOG4105Q95 Cupin 2, conserved barrel domain protein EO946_06600 ENOG4105D2H Uronic isomerase EO946_06605 ENOG4105CT4 transporter EO946_06610 ENOG4105DG4 malate L-lactate dehydrogenase EO946_06615 ENOG4105CPQ Dehydrogenase EO946_06620 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) EO946_06625 ENOG4105DMW Dehydrogenase reductase EO946_06630 ENOG4108I5G Major Facilitator superfamily EO946_06635 ENOG4107KJX Transcriptional regulator EO946_06640 ENOG4107QZW Altronate oxidoreductase EO946_06645 ENOG4105CTX dehydratase EO946_06650 ENOG4107TSN permease EO946_06660 ENOG4105JD4 ATPase yjob EO946_06675 ENOG41068K0 YCII-related domain EO946_06680 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase EO946_06685 ENOG4105KWG Pfam:DUF1696 EO946_06690 ENOG4105K7W phage-related replication protein EO946_06695 ENOG4105WEF catalase EO946_06700 ENOG410635T phage-like element pbsx protein EO946_06745 ENOG4108TFU terminase (Small subunit) EO946_06750 ENOG4105IG6 Phage terminase, large subunit EO946_06755 ENOG4108MDF Phage Portal Protein EO946_06780 ENOG41060SN EO946_06795 ENOG4105PQS phage protein EO946_06800 ENOG4105FR7 XkdM protein, phage-like element PBSX EO946_06805 ENOG4105MTC XkdN-like protein EO946_06815 ENOG4108FKH Transglycosylase SLT domain EO946_06815 ENOG4108FKH Transglycosylase SLT domain EO946_06815 ENOG4108FKH Transglycosylase SLT domain EO946_06820 ENOG4108WZM domain protein EO946_06825 ENOG4105X7F EO946_06835 ENOG4105MFU Protein of unknown function (DUF2634) EO946_06840 ENOG41066EA baseplate J family protein EO946_06845 ENOG410906S phage-like element pbsx protein xkdt EO946_06855 ENOG41068G1 EO946_06885 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EO946_06905 ENOG4105CJ3 phosphate transporter EO946_06910 ENOG4107GRR phosphate transport regulator EO946_06915 ENOG4107R7I amino acid EO946_06930 ENOG4105EDW glycosyl transferase, family 39 EO946_06935 ENOG4105CKK Glycosyl transferase, family 2 EO946_06940 ENOG4105C0H protease EO946_06950 ENOG4108ME1 Peptidase M55 D-aminopeptidase EO946_06955 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EO946_06960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EO946_06965 ENOG4105C3U ABC transporter EO946_06975 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EO946_06980 ENOG4105DTQ mandelate racemase muconate lactonizing EO946_06985 ENOG4107SN7 NLP P60 protein EO946_06990 ENOG4108JQ7 (ABC) transporter EO946_06995 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EO946_07000 ENOG4107TUM Amidinotransferase EO946_07005 ENOG4108S4H thioesterase Superfamily protein EO946_07010 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EO946_07030 ENOG4108428 Inherit from COG: -acetyltransferase EO946_07040 ENOG41080TC multidrug resistance protein EO946_07045 ENOG4105CIY formyltetrahydrofolate deformylase EO946_07050 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EO946_07065 ENOG4105K56 Transcriptional regulator EO946_07070 ENOG4108ZHJ Organic hydroperoxide resistance protein EO946_07075 ENOG4107TVC Glycosyl transferase, family 2 EO946_07080 ENOG4107Y2X deaminase EO946_07090 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EO946_07095 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EO946_07105 ENOG4108W7F transporter, permease EO946_07110 ENOG4108JJB ABC transporter EO946_07115 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein EO946_07120 ENOG4108X43 YKOF domain protein EO946_07125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EO946_07130 ENOG41062D9 Histidine kinase EO946_07140 ENOG4106849 propeptide, pepSY amd peptidase M4 EO946_07150 ENOG4105CJW magnesium transporter EO946_07155 ENOG4105V75 Transcriptional regulator EO946_07200 ENOG4105DQE DNA ligase EO946_07205 ENOG4105FDF Could be involved in DNA repair (By similarity) EO946_07210 ENOG4105BZU Histidine kinase EO946_07215 ENOG4107T5V SNARE associated Golgi EO946_07220 ENOG4107TS3 membrane protein, TerC EO946_07225 ENOG4108WZW RNA polymerase sigma EO946_07235 ENOG410681C small acid-soluble spore protein EO946_07245 ENOG4105D0M Protease HtpX homolog EO946_07265 ENOG4108TGC Acyltransferase EO946_07270 ENOG4105BZU Histidine kinase EO946_07275 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EO946_07285 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EO946_07290 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) EO946_07295 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EO946_07305 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit EO946_07310 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) EO946_07315 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) EO946_07320 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EO946_07340 ENOG4105BZU Histidine kinase EO946_07350 ENOG41090MY MarR family Transcriptional regulator EO946_07355 ENOG4105ER2 Ompa motb domain protein EO946_07360 ENOG4105E14 MotA TolQ exbB proton channel EO946_07370 ENOG4108K88 Membrane EO946_07375 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EO946_07380 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase EO946_07385 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EO946_07390 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EO946_07415 ENOG4105F0V Cell wall hydrolase EO946_07430 ENOG4105C59 p-type ATPase EO946_07440 ENOG4105DC7 peptidase M24 EO946_07450 ENOG4105CID antiterminator EO946_07460 ENOG4105KRI phosphocarrier protein (HPr EO946_07465 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EO946_07475 ENOG4105F6S Spore photoproduct lyase EO946_07485 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EO946_07490 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EO946_07495 ENOG4105K4I Scp-like extracellular EO946_07505 ENOG4105BZU Histidine kinase EO946_07510 ENOG4105CHM Aminotransferase EO946_07520 ENOG4107R88 Chemotaxis protein (CheV) EO946_07525 ENOG4105UIN EO946_07535 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein EO946_07545 ENOG4105K6S Short-chain dehydrogenase reductase Sdr EO946_07550 ENOG4105EPM Diguanylate phosphodiesterase EO946_07555 ENOG4107IN1 Protein of unknown function (DUF1797) EO946_07560 ENOG4108XRC Protein of unknown function (DUF458) EO946_07590 ENOG4105NQC Flavodoxin EO946_07600 ENOG4105CH2 amidohydrolase EO946_07610 ENOG4105D8X mechanosensitive ion channel EO946_07615 ENOG4105D3R alkyl hydroperoxide reductase EO946_07620 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EO946_07635 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EO946_07640 ENOG4105D06 uba thif-type nad fad binding protein EO946_07645 ENOG4105CVM Molybdenum cofactor synthesis domain protein EO946_07650 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EO946_07655 ENOG4108ZAF Molybdopterin EO946_07660 ENOG41067WU Molybdopterin converting factor (Subunit 1) EO946_07665 ENOG4105BZ1 (ABC) transporter EO946_07670 ENOG4105BZ1 (ABC) transporter EO946_07680 ENOG4107X8C Efflux transporter RND family MFP subunit EO946_07685 ENOG4105C19 ABC transporter EO946_07690 ENOG4107RBB ABC transporter, permease EO946_07695 ENOG4105E98 transcriptional regulator DeoR family EO946_07700 ENOG4105DE4 1-phosphofructokinase EO946_07705 ENOG4105DM4 PTS System EO946_07715 ENOG4105C3F Signal peptidase i EO946_07725 ENOG4105C5H ABC transporter EO946_07730 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EO946_07755 ENOG4105BZU Histidine kinase EO946_07765 ENOG4107ZYR domain protein EO946_07775 ENOG4105CN5 Metallo-Beta-Lactamase EO946_07785 ENOG4108X4Q Hydrolase EO946_07790 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EO946_07810 ENOG4105CPP Dehydrogenase, E1 component EO946_07815 ENOG4105C7S Dehydrogenase EO946_07820 ENOG4107QN2 dihydrolipoyl dehydrogenase EO946_07840 ENOG4105CXN decarboxylase EO946_07845 ENOG4105WBI UPF0223 protein EO946_07860 ENOG4105ECY inositol monophosphatase EO946_07870 ENOG4105JQZ Methyltransferase EO946_07910 ENOG4105CI3 gtp-binding protein typa EO946_07915 ENOG4105QA2 EO946_07930 ENOG4108IAB Phoh family EO946_07940 ENOG4105CSV Glutaminase EO946_07945 ENOG4105ZPI UPF0358 protein EO946_07950 ENOG4105CNI cell division protein FtsW EO946_07955 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EO946_07965 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EO946_07975 ENOG4105BZ9 Cytochrome C oxidase, subunit I EO946_07980 ENOG4105CCU oxidase (Subunit III) EO946_07985 ENOG41064X9 cytochrome C oxidase subunit IV EO946_08000 ENOG41080XQ Signal transduction protein with cbs domains EO946_08005 ENOG4106UY4 Inherit from COG: Scp-like extracellular EO946_08025 ENOG4105WUC UPF0298 protein EO946_08030 ENOG4106H78 methyltransferase EO946_08035 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EO946_08040 ENOG4105H20 Sporulation integral membrane protein YlbJ EO946_08045 ENOG4105D78 K07001 NTE family protein EO946_08050 ENOG41063PX domain protein EO946_08055 ENOG4105CDE UPF0348 protein EO946_08060 ENOG4105KNH Nucleic acid-binding protein EO946_08065 ENOG41067VY 50S ribosomal protein L32 EO946_08090 ENOG4108V6E Cell division protein mraZ EO946_08095 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EO946_08105 ENOG4105CJN penicillin-binding protein EO946_08110 ENOG4105CJN penicillin-binding protein EO946_08115 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EO946_08120 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EO946_08125 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EO946_08130 ENOG4105CNI cell division protein FtsW EO946_08135 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EO946_08140 ENOG4105D4A Cell wall formation (By similarity) EO946_08145 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) EO946_08150 ENOG4108R2U division initiation protein EO946_08160 ENOG4105K67 small basic protein EO946_08165 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EO946_08170 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EO946_08180 ENOG4105FFI sigma-e processing peptidase spoiiga EO946_08185 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EO946_08195 ENOG4105DKW ABC transporter EO946_08205 ENOG4105WR5 sporulation protein, YlmC YmxH family EO946_08210 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EO946_08215 ENOG4105DFA alanine racemase domain protein EO946_08220 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EO946_08225 ENOG41067XK integral membrane protein EO946_08230 ENOG4105DBK s4 domain protein EO946_08240 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EO946_08250 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EO946_08255 ENOG4105C34 Pseudouridine synthase EO946_08260 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EO946_08270 ENOG4105CXT aspartate transcarbamylase EO946_08280 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EO946_08285 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EO946_08290 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EO946_08295 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) EO946_08300 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EO946_08305 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EO946_08310 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EO946_08320 ENOG4107S4M Sulfate adenylate transferase EO946_08325 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) EO946_08330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EO946_08335 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EO946_08340 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EO946_08345 ENOG4105F23 Fibronectin-binding protein EO946_08355 ENOG4105DSJ YicC domain protein EO946_08360 ENOG4105KC4 UPF0296 protein EO946_08365 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EO946_08375 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EO946_08380 ENOG4105C25 Primosomal protein n' EO946_08385 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EO946_08390 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EO946_08395 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EO946_08400 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EO946_08405 ENOG4108ZF3 Phosphatase EO946_08410 ENOG4105D9P serine threonine protein kinase EO946_08415 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EO946_08420 ENOG4105DJV ribulose-phosphate 3-epimerase EO946_08425 ENOG4105FJ0 thiamine EO946_08435 ENOG4105VB9 50S ribosomal protein l28 EO946_08440 ENOG4108ZAA Alkaline-shock protein EO946_08445 ENOG4105DP4 dak2 domain fusion protein ylov EO946_08455 ENOG4105EJQ L-serine dehydratase EO946_08460 ENOG4105CB5 ATP-dependent DNA helicase recG EO946_08465 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) EO946_08475 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EO946_08480 ENOG4105CHR reductase EO946_08485 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EO946_08490 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EO946_08495 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EO946_08500 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EO946_08515 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) EO946_08525 ENOG4105K5M 30s ribosomal protein S16 EO946_08530 ENOG4108BW8 UPF0109 protein EO946_08540 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EO946_08545 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EO946_08550 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EO946_08560 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EO946_08570 ENOG4105VM1 flagellar EO946_08575 ENOG4105CMV Succinyl-CoA synthetase subunit beta EO946_08580 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EO946_08585 ENOG4105C79 DNA protecting protein DprA EO946_08590 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EO946_08595 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EO946_08600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EO946_08605 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EO946_08620 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EO946_08625 ENOG4108ZC9 flagellar basal-body rod protein flgc EO946_08630 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EO946_08635 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EO946_08640 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EO946_08655 ENOG4106YF4 Flagellar biosynthesis chaperone EO946_08665 ENOG410696Y Flagellar hook-length control protein EO946_08670 ENOG410822I Flagellar hook capping protein EO946_08675 ENOG4108JQA flagellar EO946_08680 ENOG41068WV flagellar FlbD family protein EO946_08690 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EO946_08695 ENOG4105DD5 Flagellar motor switch protein EO946_08700 ENOG4107YTP response regulator receiver protein EO946_08710 ENOG4105CN7 Flagellar biosynthetic protein FliP EO946_08715 ENOG4105VS8 Flagellar biosynthetic protein fliq EO946_08720 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EO946_08725 ENOG4105D00 flagellar biosynthetic protein flhB EO946_08730 ENOG4105D7B Flagellar biosynthesis protein flha EO946_08735 ENOG4105FZW flagellar biosynthesis regulator FlhF EO946_08745 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EO946_08750 ENOG4105CBS Chea signal transduction histidine kinase EO946_08755 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis EO946_08770 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EO946_08780 ENOG4105CE9 30S ribosomal protein S2 EO946_08785 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EO946_08795 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EO946_08800 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EO946_08805 ENOG4105KNE Phosphatidate cytidylyltransferase EO946_08815 ENOG4105DZP Membrane-associated zinc metalloprotease EO946_08820 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EO946_08825 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EO946_08830 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EO946_08835 ENOG4105CHV Transcription elongation factor NusA EO946_08840 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EO946_08845 ENOG4105VHM ribosomal protein EO946_08850 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EO946_08855 ENOG4105W7A Protein of unknown function (DUF503) EO946_08860 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EO946_08865 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EO946_08870 ENOG4105DTN riboflavin biosynthesis protein ribF EO946_08875 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EO946_08880 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EO946_08890 ENOG4105C1V Peptidase, M16 EO946_08900 ENOG4105E35 Dipicolinate synthase subunit A EO946_08905 ENOG4108S0H Dipicolinic acid synthetase, b subunit EO946_08910 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EO946_08920 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EO946_08930 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EO946_08940 ENOG4105CNU cell division protein FtsK EO946_08945 ENOG4105FDP GntR family transcriptional regulator EO946_08965 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EO946_08970 ENOG4105XZV Protein of unknown function (DUF3243) EO946_08985 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EO946_08990 ENOG4105CEV competence damage-inducible protein EO946_09000 ENOG4108A04 Beta-lactamase EO946_09005 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) EO946_09010 ENOG4105D48 metallophosphoesterase EO946_09015 ENOG4105MCT stage V sporulation protein S EO946_09025 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EO946_09030 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EO946_09045 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EO946_09050 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EO946_09065 ENOG4105IIP Membrane EO946_09070 ENOG4105W1N transcriptional regulator EO946_09075 ENOG4108151 Beta-lactamase domain protein EO946_09085 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EO946_09095 ENOG4107QKG PfaD family EO946_09100 ENOG41062T2 Acyl carrier protein EO946_09105 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase EO946_09110 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase EO946_09115 ENOG4108MGH Enoyl-CoA hydratase EO946_09120 ENOG4108KQ6 Enoyl-CoA hydratase EO946_09125 ENOG4105C0W non-ribosomal peptide synthetase EO946_09130 ENOG4107SQU synthase EO946_09140 ENOG4105C0W non-ribosomal peptide synthetase EO946_09150 ENOG4106A3M Cytochrome p-450 EO946_09165 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EO946_09175 ENOG4105K7W phage-related replication protein EO946_09180 ENOG4108X3M OsmC Ohr family protein EO946_09205 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EO946_09210 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EO946_09225 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EO946_09230 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EO946_09235 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EO946_09240 ENOG4105U6W MutT NUDIX family protein EO946_09245 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EO946_09255 ENOG4106F1P AAA ATPase, central domain protein EO946_09260 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EO946_09265 ENOG4105CXI aluminum resistance protein EO946_09270 ENOG4105KV4 Transcriptional regulator EO946_09275 ENOG4105C5F glutamine synthetase EO946_09300 ENOG4105CT4 transporter EO946_09305 ENOG4105DSG hydrolase family 43 EO946_09320 ENOG4105CMG Carbohydrate kinase EO946_09335 ENOG4105C54 Major Facilitator superfamily EO946_09340 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EO946_09350 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EO946_09415 ENOG4105CAH Chromate EO946_09435 ENOG4105FVX EO946_09445 ENOG4105K7W phage-related replication protein EO946_09455 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) EO946_09470 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EO946_09480 ENOG4108SVB resolvase EO946_09485 ENOG4105VPS UPF0291 protein EO946_09490 ENOG4105CV1 Transketolase (EC 2.2.1.1) EO946_09510 ENOG4107QIV Cytochrome c biogenesis protein EO946_09535 ENOG4107DZX Small, acid-soluble spore protein P EO946_09545 ENOG4108I0Z Aconitate hydratase EO946_09550 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EO946_09565 ENOG41067CD Small, acid-soluble spore protein Tlp EO946_09575 ENOG4105MI2 EO946_09580 ENOG4105W8X HesB YadR YfhF-family protein EO946_09585 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EO946_09590 ENOG4105K4P CoA-binding domain protein EO946_09595 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EO946_09615 ENOG4107QWR cellulase (EC 3.2.1.4) EO946_09630 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EO946_09635 ENOG4107T5V SNARE associated Golgi EO946_09675 ENOG4107QX3 carboxylase EO946_09680 ENOG4105E39 Enoyl-CoA hydratase EO946_09685 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EO946_09690 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit EO946_09695 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EO946_09700 ENOG4105CEY Amp-dependent synthetase and ligase EO946_09705 ENOG4105C1G acyl-Coa dehydrogenase EO946_09720 ENOG4105F32 YngK protein EO946_09725 ENOG4106U2H Protein of unknown function (DUF1360) EO946_09750 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family EO946_09755 ENOG4108N2V aldose 1-epimerase EO946_09760 ENOG4107QJQ Mate efflux family protein EO946_09785 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase EO946_09810 ENOG41068G1 EO946_09820 ENOG410651K Teichoic acid biosynthesis protein C EO946_09825 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase EO946_10055 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EO946_10070 ENOG4105BZ8 glutamate synthase EO946_10075 ENOG4105CBC glutamate synthase EO946_10080 ENOG4105C5Q Transcriptional regulator EO946_10085 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EO946_10115 ENOG4108UB7 EO946_10120 ENOG41068WN EO946_10145 ENOG4105IE8 Alpha-ketoglutarate permease EO946_10150 ENOG4107U6E carbohydrate kinase FGGY EO946_10155 ENOG4108M3J Dehydrogenase EO946_10160 ENOG4108J2R molybdopterin oxidoreductase EO946_10190 ENOG4105EC8 Methyl-accepting chemotaxis EO946_10200 ENOG4108YQE rare lipoprotein a EO946_10205 ENOG4105XPP Protein of unknown function (DUF1275) EO946_10210 ENOG4108NR7 pectate lyase EO946_10230 ENOG4108RAV Conserved protein EO946_10270 ENOG41073R8 VanW family EO946_10280 ENOG4105VMP Transcriptional regulator EO946_10285 ENOG4105NX3 Membrane EO946_10295 ENOG4108Q5Y Membrane EO946_10320 ENOG4108V4B ThiJ pfpI EO946_10325 ENOG4108J4B Beta-lactamase EO946_10335 ENOG4108M1A Chitin-binding protein EO946_10365 ENOG4108SHN Glycosyl transferase, family 2 EO946_10410 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EO946_10430 ENOG4108RZ2 Glycoside hydrolase family 16 EO946_10450 ENOG4108Z7R Chaperone CsaA EO946_10455 ENOG4105FTV AraC Family Transcriptional Regulator EO946_10460 ENOG4108HJF gCN5-related N-acetyltransferase EO946_10480 ENOG4105D29 Helix-turn-helix type 11 domain protein EO946_10490 ENOG4105KTU Transcriptional regulator, arsr family EO946_10500 ENOG4108SJC Membrane EO946_10520 ENOG4105ECK Fatty Acid Desaturase EO946_10525 ENOG4108ZGX Histidine kinase EO946_10530 ENOG4108S01 response regulator EO946_10535 ENOG4107RUZ Sss sodium solute transporter superfamily EO946_10540 ENOG41069ER domain protein EO946_10545 ENOG4105C9U ATP-dependent DNA helicase RecQ EO946_10555 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EO946_10560 ENOG4105SCY DNAK suppressor EO946_10575 ENOG4105C26 Dehydrogenase EO946_10580 ENOG4105EWU Squalene--hopene cyclase EO946_10585 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EO946_10590 ENOG4105C8J )-transporter EO946_10595 ENOG4105C09 Bile acid EO946_10600 ENOG4105C7S Dehydrogenase EO946_10610 ENOG4107T89 von Willebrand factor, type A EO946_10615 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EO946_10625 ENOG4105K4H Nlp p60 protein EO946_10630 ENOG41087PP glycosyltransferase MGT family EO946_10640 ENOG4107QMU Mate efflux family protein EO946_10645 ENOG4106SCS STAS domain EO946_10665 ENOG4105FR1 rard protein EO946_10680 ENOG41090U3 tautomerase EO946_10700 ENOG4105FBA Phospholipase Carboxylesterase EO946_10715 ENOG4105E1V na solute symporter EO946_10735 ENOG4108VXD carboxy-peptidase EO946_10740 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EO946_10750 ENOG4106Z5R EO946_10755 ENOG410841Q phosphoesterase PA-phosphatase related protein EO946_10790 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EO946_10795 ENOG4108TSC N-acetyltransferase EO946_10800 ENOG4107S4Y M20 DapE family protein YgeY EO946_10815 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EO946_10855 ENOG4107T32 3-phytase (EC 3.1.3.8) EO946_10860 ENOG4105C5E polysaccharide biosynthesis protein EO946_10865 ENOG4105E0X reductase EO946_10870 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EO946_10890 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) EO946_10895 ENOG41090WU lipolytic protein G-D-S-L family EO946_10900 ENOG4108KF3 Electron transport protein SCO1 SenC EO946_10910 ENOG4105C7B Threonine dehydratase EO946_10920 ENOG4108UT2 hemolysin iii EO946_10930 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EO946_10950 ENOG4107YX5 Pfam:DUF548 EO946_10955 ENOG4108Y6J UPF0403 protein EO946_10960 ENOG4105C01 Dihydroxy-acid dehydratase EO946_10975 ENOG4108V06 Glutathione peroxidase EO946_10980 ENOG4105CVG Homoserine O-transsuccinylase EO946_11025 ENOG41081VK Ribonuclease EO946_11050 ENOG410890F Dynamin family EO946_11065 ENOG41065KQ synthase EO946_11070 ENOG4105C2W permease EO946_11075 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) EO946_11080 ENOG4105CTD carboxy-peptidase EO946_11085 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) EO946_11090 ENOG4108UHU Aldolase EO946_11095 ENOG4105D7K pfkb domain protein EO946_11100 ENOG4108M60 Transcriptional regulator EO946_11110 ENOG4105CHR reductase EO946_11115 ENOG4105DVT helicase EO946_11130 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EO946_11145 ENOG4108UKS UPF0398 protein EO946_11160 ENOG4107X2U Inherit from COG: Exonuclease-like protein EO946_11165 ENOG4108I5C dEAD DEAH box helicase EO946_11215 ENOG4105BZ4 penicillin-binding protein EO946_11225 ENOG4105CSM endonuclease III EO946_11235 ENOG4105C5S asparaginyl-tRNA synthetase EO946_11240 ENOG4105CHM Aminotransferase EO946_11250 ENOG4105YAC EO946_11255 ENOG4105DVT helicase EO946_11260 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EO946_11265 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EO946_11270 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EO946_11280 ENOG4105DJ0 Poly(A) Polymerase EO946_11285 ENOG4105CPK Glycosyl transferase (Group 1 EO946_11290 ENOG4105FJR Lmbe family EO946_11295 ENOG4108Z5K methylglyoxal synthase EO946_11300 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EO946_11305 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EO946_11310 ENOG4108JYZ YitT family EO946_11330 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EO946_11350 ENOG41068YB TPR repeat-containing protein EO946_11360 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EO946_11370 ENOG4105CIH Imidazole acetol-phosphate transaminase EO946_11380 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EO946_11385 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EO946_11395 ENOG4108I0Q anthranilate phosphoribosyltransferase EO946_11400 ENOG4105CRQ synthase (Component I) EO946_11405 ENOG4105KHN chorismate mutase EO946_11410 ENOG4105D49 3-dehydroquinate synthase EO946_11415 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EO946_11420 ENOG4105BZU Histidine kinase EO946_11425 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EO946_11430 ENOG4105EAH synthase EO946_11435 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EO946_11440 ENOG4105XXQ heptaprenyl diphosphate synthase component I EO946_11450 ENOG4105EUJ GTP cyclohydrolase i EO946_11455 ENOG4105K70 DNA-binding protein EO946_11460 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) EO946_11475 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EO946_11480 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EO946_11485 ENOG41065D1 EO946_11490 ENOG4105S2F EO946_11505 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EO946_11510 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EO946_11515 ENOG4105CAT Cytidine monophosphate kinase EO946_11530 ENOG4105MSI germination protein ypeb EO946_11540 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) EO946_11545 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EO946_11560 ENOG4107RGJ metallophosphoesterase EO946_11575 ENOG4105I7S Abortive infection protein EO946_11580 ENOG4105C9U ATP-dependent DNA helicase RecQ EO946_11585 ENOG4105T7X EO946_11595 ENOG4108SAX Membrane EO946_11600 ENOG4108JQ1 Dehydrogenase EO946_11605 ENOG4105FF2 Type I DHQase EO946_11620 ENOG4105BZU Histidine kinase EO946_11625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EO946_11630 ENOG4105CRE cytochrome C EO946_11635 ENOG4107TWT Cytochrome c biogenesis protein EO946_11645 ENOG4105FE9 pseudouridine synthase EO946_11655 ENOG4108JIC nucleoside recognition domain protein EO946_11660 ENOG4105DZ1 carboxypeptidase EO946_11670 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EO946_11675 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EO946_11690 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EO946_11695 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EO946_11700 ENOG4108R6K riboflavin synthase, subunit alpha EO946_11705 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EO946_11715 ENOG4105C3F Signal peptidase i EO946_11725 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) EO946_11735 ENOG4107ZE5 PPIases accelerate the folding of proteins EO946_11745 ENOG4105PTM secreted protein EO946_11750 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EO946_11760 ENOG4105G6R Stage v sporulation protein ae EO946_11770 ENOG4105CZ3 stage V sporulation protein ad EO946_11775 ENOG41090VF Stage v sporulation protein ac EO946_11790 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EO946_11795 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EO946_11800 ENOG41082AN stage II sporulation protein EO946_11805 ENOG4105DZ1 carboxypeptidase EO946_11810 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EO946_11815 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EO946_11820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EO946_11830 ENOG4105I3K Ferric uptake regulator, Fur family EO946_11835 ENOG4105MZ9 stage II sporulation protein m EO946_11850 ENOG4105DFD Na H antiporter EO946_11855 ENOG4108IJ0 Aspartate ammonia-lyase EO946_11860 ENOG4105HDK L-asparaginase EO946_11865 ENOG4108IMY Transcriptional regulator EO946_11885 ENOG4108YZ4 nudix hydrolase EO946_11895 ENOG4105CPC Aldo Keto reductase EO946_11910 ENOG4105CNI cell division protein FtsW EO946_11915 ENOG4105CNI cell division protein FtsW EO946_11930 ENOG4106HZJ EO946_11935 ENOG4105RHY Pfam:UPF0157 EO946_11940 ENOG4105KAC Antibiotic biosynthesis monooxygenase EO946_11945 ENOG4108XET gCN5-related N-acetyltransferase EO946_11955 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EO946_11970 ENOG4105E5W Transporter EO946_11975 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase EO946_11990 ENOG4108IXY short-chain dehydrogenase reductase EO946_11995 ENOG41069FQ Metallo-beta-lactamase superfamily EO946_12000 ENOG4105II7 pyrroline-5-carboxylate reductase EO946_12010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EO946_12025 ENOG410861F 50S ribosomal protein L33 EO946_12030 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EO946_12035 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EO946_12040 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EO946_12045 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EO946_12055 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) EO946_12060 ENOG4108NA0 Uncharacterized conserved protein (COG2071) EO946_12065 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EO946_12070 ENOG4108HNZ carboxyl transferase EO946_12075 ENOG4108ZVT methylmalonyl-coA epimerase EO946_12080 ENOG4108VZI ErfK ybiS ycfS ynhG family protein EO946_12085 ENOG4108QEG Membrane EO946_12090 ENOG4105CDA abc transporter atp-binding protein EO946_12095 ENOG4105E5Q amino acid AbC transporter EO946_12100 ENOG4108HW3 (ABC) transporter EO946_12105 ENOG4108Y6J UPF0403 protein EO946_12110 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) EO946_12125 ENOG4105C7S Dehydrogenase EO946_12130 ENOG4105CPP Dehydrogenase, E1 component EO946_12145 ENOG4105CKM Branched-chain carboxylic acid kinase EO946_12150 ENOG4107RDP Dehydrogenase EO946_12160 ENOG4108JUB Transcriptional regulator EO946_12165 ENOG4106CCJ Protein of unknown function (DUF2627) EO946_12170 ENOG4105CR4 methylisocitrate lyase EO946_12175 ENOG4105DXD 2-methylcitrate dehydratase EO946_12185 ENOG4105C1G acyl-Coa dehydrogenase EO946_12190 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EO946_12200 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EO946_12205 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EO946_12220 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EO946_12225 ENOG4107QQR Sporulation EO946_12235 ENOG4105S1Z Stage IV sporulation protein B EO946_12240 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EO946_12245 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EO946_12250 ENOG4105DX0 Hemolysin A EO946_12260 ENOG4105CTB Polyprenyl synthetase EO946_12265 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EO946_12270 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EO946_12275 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EO946_12280 ENOG4105M7K Involved in the transcription termination process (By similarity) EO946_12285 ENOG4108ZSR alkaline shock protein EO946_12290 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EO946_12310 ENOG410644B Stage III sporulation protein af EO946_12320 ENOG4105KQ4 Stage iii sporulation protein ad EO946_12325 ENOG4108CQH stage III sporulation protein AC EO946_12330 ENOG4105KR5 Stage iii sporulation protein EO946_12335 ENOG4105CD2 stage iii sporulation protein aa EO946_12345 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EO946_12350 ENOG4105DC7 peptidase M24 EO946_12355 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EO946_12365 ENOG4105CBJ Metal-dependent enzyme EO946_12380 ENOG4105KST dependent repressor EO946_12385 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) EO946_12390 ENOG4105WZW rhodanese family EO946_12395 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EO946_12400 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EO946_12405 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EO946_12410 ENOG4105C0D helicase EO946_12430 ENOG4108IMY Transcriptional regulator EO946_12440 ENOG4105VFR signal peptidase EO946_12500 ENOG41080XP Cbs domain EO946_12510 ENOG4105C37 (CBS) domain EO946_12535 ENOG4105C5X domain protein EO946_12560 ENOG4105E0M Sulfatase EO946_12575 ENOG4107ZXI Rhomboid family EO946_12585 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EO946_12590 ENOG4105WDJ 50S ribosomal protein L33 EO946_12610 ENOG41068DG YceG-like family EO946_12615 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EO946_12620 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EO946_12625 ENOG4105E2Z phosphate ABC transporter (Permease EO946_12630 ENOG4105C8U phosphate abc transporter EO946_12635 ENOG4105CVA phosphate EO946_12640 ENOG4107RF6 penicillin-binding protein EO946_12650 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EO946_12655 ENOG4105SXS Protein of unknown function (DUF456) EO946_12670 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EO946_12675 ENOG41063Y9 EO946_12680 ENOG4108U5J '-nucleotidase EO946_12685 ENOG4105N80 Ferric uptake regulator, Fur family EO946_12690 ENOG4108JYZ YitT family EO946_12695 ENOG41069ZM Protein of unknown function (DUF2624) EO946_12700 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EO946_12715 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EO946_12720 ENOG4105EGD dinuclear metal center protein, YbgI family EO946_12735 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EO946_12740 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EO946_12745 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 EO946_12750 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EO946_12760 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EO946_12765 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EO946_12770 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) EO946_12780 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EO946_12785 ENOG4105KG3 cytidine deaminase EO946_12790 ENOG4107YR5 Diacylglycerol kinase EO946_12795 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EO946_12800 ENOG4105CTJ Metal Dependent Phosphohydrolase EO946_12805 ENOG4105C9A Phoh family EO946_12810 ENOG4105EI1 sporulation protein yqfd EO946_12815 ENOG41068P3 sporulation protein YqfC EO946_12825 ENOG4105DI5 UPF0365 protein EO946_12830 ENOG4105F7J membrane-bound serine protease EO946_12835 ENOG4105KTH gatB Yqey EO946_12850 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EO946_12855 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EO946_12860 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EO946_12870 ENOG4105CFG Acts as a chaperone (By similarity) EO946_12875 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EO946_12880 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EO946_12885 ENOG4105CSA Coproporphyrinogen iii oxidase EO946_12890 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EO946_12900 ENOG4108ZRV stage ii sporulation protein p EO946_12905 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) EO946_12910 ENOG41082YS Binds directly to 16S ribosomal RNA EO946_12915 ENOG4105TQK DNA polymerase iii, delta' subunit EO946_12930 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EO946_12935 ENOG4108UK2 deaminase EO946_12940 ENOG4105KQC Competence protein EO946_12950 ENOG4108D32 Methyltransferase EO946_12960 ENOG4108WF2 Metal Dependent Phosphohydrolase EO946_12965 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EO946_12970 ENOG410812S Rna-binding protein EO946_12975 ENOG4105E2X shikimate dehydrogenase EO946_12980 ENOG4105CQW ribosome biogenesis GTPase YqeH EO946_12985 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EO946_13005 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EO946_13010 ENOG41080BT SNARE associated Golgi EO946_13025 ENOG4105WFK nuclease EO946_13030 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EO946_13035 ENOG4107Y5K Resolvase EO946_13045 ENOG4105C9Q fumarate hydratase class II EO946_13050 ENOG4107RSM transcriptional regulator EO946_13070 ENOG4105EA8 2-Nitropropane dioxygenase EO946_13075 ENOG4105K56 Transcriptional regulator EO946_13085 ENOG4105KVH Transcriptional regulator EO946_13090 ENOG4108DBC nitroreductase EO946_13095 ENOG4108R6W Transcriptional regulator, ARAC family EO946_13105 ENOG4105EMU Dehydrogenase EO946_13115 ENOG41090E6 transcriptional regulator MERR family EO946_13125 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EO946_13135 ENOG41073TP transcriptional regulator EO946_13145 ENOG4105CTQ phosphohexokinase EO946_13150 ENOG4105CTQ phosphohexokinase EO946_13165 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EO946_13170 ENOG4108HHA Transketolase EO946_13185 ENOG4105WAB arsR family transcriptional regulator EO946_13200 ENOG4105BZG amino acid carrier protein EO946_13210 ENOG4105UNS Pfam:DUF419 EO946_13225 ENOG4108MEK Metal-binding protein YodA EO946_13230 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein EO946_13235 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein EO946_13245 ENOG4105PGS Spore coat protein EO946_13250 ENOG4105E2A Dehydrogenase EO946_13265 ENOG4105KRI phosphocarrier protein (HPr EO946_13270 ENOG4105CPC Aldo Keto reductase EO946_13275 ENOG4105CF7 AraC family transcriptional regulator EO946_13280 ENOG4105VUF Transcriptional regulator EO946_13285 ENOG4105VUF Transcriptional regulator EO946_13290 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EO946_13295 ENOG4105DQ4 alcohol dehydrogenase EO946_13300 ENOG4108Z0Z intracellular protease Pfpi family EO946_13305 ENOG4108HKT sucrose-6-phosphate hydrolase EO946_13315 ENOG4105F3R pts system mannose fructose sorbose family iid EO946_13320 ENOG4105ETZ PTS System EO946_13325 ENOG4108IQ3 PTS system EO946_13330 ENOG4105YHU PTS system EO946_13335 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EO946_13350 ENOG4105C85 amino acid EO946_13355 ENOG4105N14 lysine exporter protein LysE YggA EO946_13360 ENOG4108NGU Transcriptional regulator EO946_13365 ENOG4105JVQ RNA Polymerase EO946_13370 ENOG4108P49 AntiSigma factor EO946_13375 ENOG4105EXC Acyl-transferase EO946_13380 ENOG4105WDR EO946_13385 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EO946_13390 ENOG41082JN Transcriptional regulator EO946_13410 ENOG4105TMB Formate nitrite transporter EO946_13415 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) EO946_13420 ENOG4108JB9 formate dehydrogenase EO946_13435 ENOG4105C28 cystathionine EO946_13450 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) EO946_13465 ENOG4107XRG penicillin-binding protein EO946_13470 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EO946_13475 ENOG4105DBI uridine monophosphokinase EO946_13480 ENOG4105CFP Peptidase U32 EO946_13485 ENOG4105XYU peptidase (U32 family) EO946_13490 ENOG4108VQJ O-methyltransferase EO946_13495 ENOG4105HHA aminodeoxychorismate lyase EO946_13500 ENOG4105VPH UPF0473 protein EO946_13505 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EO946_13510 ENOG4105VBH UPF0297 protein EO946_13515 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EO946_13520 ENOG4105C02 permease EO946_13530 ENOG41060CR EO946_13540 ENOG4105C7H Helicase, RecD TraA family EO946_13550 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EO946_13555 ENOG4105C3J Cysteine desulfurase EO946_13565 ENOG4105D1H recombination factor protein RarA EO946_13575 ENOG4105CUZ uba thif-type nad fad binding protein EO946_13585 ENOG4105C9M aspartyl-trna synthetase EO946_13590 ENOG4105CUT histidyl-tRNA synthetase EO946_13600 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EO946_13610 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EO946_13615 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EO946_13620 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EO946_13625 ENOG41067VP Protein of unknown function (DUF1049) EO946_13630 ENOG4105NCW Trka-c domain protein EO946_13635 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EO946_13645 ENOG4105CKP Polysaccharide Biosynthesis Protein EO946_13650 ENOG4108QG2 Membrane EO946_13655 ENOG4105NAP EO946_13660 ENOG4105VIE preprotein translocase, subunit YajC EO946_13665 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EO946_13670 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EO946_13675 ENOG41061AI Protein of unknown function (DUF2905) EO946_13680 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EO946_13685 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EO946_13695 ENOG4105IE8 Alpha-ketoglutarate permease EO946_13700 ENOG4105CK5 oxidoreductase EO946_13715 ENOG4105BZG amino acid carrier protein EO946_13720 ENOG4105CDY transcriptional regulatory protein EO946_13730 ENOG4106678 morphogenetic protein associated with SpoVID EO946_13735 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EO946_13740 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EO946_13745 ENOG4108IYU L-aspartate oxidase EO946_13760 ENOG4105CQC Prephenate dehydratase EO946_13765 ENOG41090I5 UPF0735 ACT domain-containing protein EO946_13770 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EO946_13785 ENOG4105K46 50S ribosomal protein l27 EO946_13790 ENOG4105X36 (ribosomal) protein EO946_13795 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EO946_13810 ENOG4107QMS site-determining protein EO946_13815 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EO946_13820 ENOG4105YHC Rod shape-determining protein MreD EO946_13825 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EO946_13830 ENOG4105DFF Rod shape-determining protein mreb EO946_13835 ENOG4105W5Q DNA repair protein (RadC EO946_13840 ENOG4108Z03 MAF-like protein EO946_13850 ENOG4106A3R peptidase EO946_13855 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EO946_13860 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EO946_13870 ENOG4106AR7 Spore coat protein EO946_13875 ENOG41068KH stage VI sporulation protein D EO946_13880 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EO946_13885 ENOG4105D52 delta-aminolevulinic acid dehydratase EO946_13895 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EO946_13905 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EO946_13915 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EO946_13920 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EO946_13925 ENOG4108IUQ atp-dependent protease EO946_13930 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EO946_13935 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EO946_13945 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EO946_13950 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EO946_13955 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EO946_13960 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EO946_13965 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EO946_13970 ENOG4108ZP8 Acetolactate synthase small subunit EO946_13975 ENOG4105C7K acetolactate synthase EO946_13985 ENOG4105I4A GCN5-related N-acetyltransferase EO946_13995 ENOG4107KM7 Heat induced stress protein YflT EO946_14005 ENOG4105M59 Phosphodiesterase, mj0936 family EO946_14010 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EO946_14015 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EO946_14020 ENOG4108XJQ germination protein EO946_14025 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EO946_14030 ENOG41067TZ transcriptional regulator, MarR family EO946_14035 ENOG4105PFC Transcriptional regulator EO946_14045 ENOG4105E33 succinate dehydrogenase EO946_14055 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EO946_14065 ENOG4105CFH Aspartokinase EO946_14075 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EO946_14080 ENOG4105K63 Thioredoxin EO946_14090 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) EO946_14095 ENOG4105C10 Electron transfer flavoprotein EO946_14100 ENOG4105BZJ Electron transfer flavoprotein EO946_14105 ENOG41060WC Enoyl-CoA hydratase EO946_14110 ENOG4107Z3H Transcriptional regulator, TetR family EO946_14115 ENOG4105CEY Amp-dependent synthetase and ligase EO946_14125 ENOG4105C98 muts2 protein EO946_14130 ENOG4105DCG PHP domain protein EO946_14145 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EO946_14150 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EO946_14155 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EO946_14165 ENOG4108RWN rrna methyltransferase EO946_14170 ENOG41067MF small acid-soluble spore protein EO946_14175 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EO946_14180 ENOG4105D2K citrate carrier protein EO946_14185 ENOG4105CQB FAD linked oxidase domain protein EO946_14190 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EO946_14220 ENOG4105K7K Transcriptional regulator EO946_14225 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) EO946_14230 ENOG4105DRS transport system, permease EO946_14245 ENOG4108MDK Dehydrogenase EO946_14255 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EO946_14260 ENOG4105EF1 ribulokinase EO946_14270 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase EO946_14275 ENOG4105CN9 Peptidase m42 family protein EO946_14285 ENOG410696E Membrane EO946_14290 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EO946_14295 ENOG4105VJV 50s ribosomal protein L35 EO946_14300 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EO946_14315 ENOG41067MG lrgb family EO946_14325 ENOG4105DY9 regulatoR EO946_14330 ENOG4108HRK Histidine kinase EO946_14335 ENOG4105U0R haloacid dehalogenase-like hydrolase EO946_14340 ENOG4105C22 threonyL-tRNA synthetase EO946_14345 ENOG4108TDW sporulation protein YtxC EO946_14365 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EO946_14370 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EO946_14375 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EO946_14380 ENOG4105KVH Transcriptional regulator EO946_14385 ENOG4105F27 Major Facilitator EO946_14390 ENOG4105CV8 reductase EO946_14395 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EO946_14405 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EO946_14410 ENOG4105C2M dna polymerase I EO946_14415 ENOG4105BZU Histidine kinase EO946_14420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EO946_14425 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EO946_14430 ENOG4108HMX isocitrate dehydrogenase (NADP) EO946_14435 ENOG4105BZN citrate synthase EO946_14445 ENOG4108REF Sporulation integral membrane protein ytvi EO946_14450 ENOG4105FS0 cytoplasmic membrane protein EO946_14455 ENOG4105CA9 Pyruvate kinase EO946_14460 ENOG4105CTQ phosphohexokinase EO946_14470 ENOG4108IEY Carboxyl transferase domain EO946_14475 ENOG4105C6K Malic enzyme EO946_14480 ENOG4105C0B DNA polymerase III (alpha subunit) EO946_14485 ENOG4105VV2 EO946_14495 ENOG4106EVM EO946_14500 ENOG4105SFS phosphoesterase RecJ domain protein EO946_14515 ENOG4105E8R UPF0173 metal-dependent hydrolase EO946_14530 ENOG4105CH7 arginosuccinase EO946_14535 ENOG4105CDH Citrulline--aspartate ligase EO946_14540 ENOG4105EPU Molybdenum cofactor synthesis domain protein EO946_14545 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EO946_14555 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EO946_14560 ENOG4105KBJ sporulation protein ytfj EO946_14570 ENOG4105VK3 rdd domain containing protein EO946_14575 ENOG4105D07 Signal peptide peptidase, SppA EO946_14580 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EO946_14585 ENOG4105EFZ amidohydrolase EO946_14590 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EO946_14625 ENOG4105U5Y Transcriptional regulator EO946_14635 ENOG4105BZU Histidine kinase EO946_14645 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EO946_14650 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EO946_14660 ENOG4105F1V Acetoin utilization protein EO946_14665 ENOG4105W87 Cbs domain EO946_14670 ENOG4105DGU Histone deacetylase EO946_14675 ENOG4105ER2 Ompa motb domain protein EO946_14680 ENOG4107R0U MotA TolQ exbB proton channel EO946_14685 ENOG4105ETE Transcriptional regulator (LacI family EO946_14690 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EO946_14710 ENOG4105DFU Cell wall formation (By similarity) EO946_14720 ENOG4108VDD TRNA binding domain protein EO946_14740 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ EO946_14755 ENOG4105C6K Malic enzyme EO946_14760 ENOG4105C8F Beta-lactamase domain protein EO946_14765 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EO946_14775 ENOG4108V15 phosphotransferase enzyme family EO946_14780 ENOG4108IUM Glycogen debranching enzyme EO946_14795 ENOG4107F58 2'-5' rna ligase EO946_14800 ENOG4105C6T cysteine synthase EO946_14805 ENOG4107QSE Dipeptidase EO946_14810 ENOG4105C7N Xanthine uracil vitamin C permease EO946_14825 ENOG4105YW5 deoR family transcriptional regulator EO946_14840 ENOG4105CBX hi0933 family EO946_14845 ENOG4105C94 Transporter EO946_14855 ENOG4105MU9 integral membrane protein EO946_14860 ENOG4105DDC Oxidoreductase domain protein EO946_14870 ENOG4105F5H Glycosyl Hydrolase Family 88 EO946_14880 ENOG41075H3 AraC family transcriptional regulator EO946_14890 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EO946_14900 ENOG4106A3M Cytochrome p-450 EO946_14905 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EO946_14915 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EO946_14920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EO946_14935 ENOG4105NTD Inherit from COG: Hydrolase EO946_14950 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component EO946_14955 ENOG4105I1K ABC transporter EO946_14965 ENOG41085GJ domain protein EO946_14970 ENOG4105C8T Leucyl-tRNA synthetase EO946_14980 ENOG4105BZU Histidine kinase EO946_14985 ENOG410605W Major Facilitator EO946_14990 ENOG4106UBQ EO946_15000 ENOG4105C19 ABC transporter EO946_15005 ENOG4105EWM Histidine kinase EO946_15015 ENOG4107R34 abc transporter permease protein EO946_15020 ENOG4105C19 ABC transporter EO946_15035 ENOG4105DVE abc transporter atp-binding protein EO946_15040 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EO946_15055 ENOG4105N5T Radical SAM Protein EO946_15070 ENOG4105E8V Alpha Beta Hydrolase Fold protein EO946_15075 ENOG4108Z0R Transferase EO946_15080 ENOG4105C85 amino acid EO946_15085 ENOG4105CAQ asparagine synthetase EO946_15090 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EO946_15095 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase EO946_15110 ENOG4105D2X ABC transporter substrate-binding protein EO946_15120 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EO946_15145 ENOG4108RMU ferritin dps family protein EO946_15160 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) EO946_15165 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EO946_15170 ENOG4108V2W Carbonate dehydratase EO946_15195 ENOG4105CC5 ABC transporter EO946_15200 ENOG4105CC5 ABC transporter EO946_15205 ENOG4105DIK (ABC) transporter EO946_15210 ENOG4105DSE periplasmic solute binding protein EO946_15215 ENOG4105DTQ mandelate racemase muconate lactonizing EO946_15220 ENOG4105CEY Amp-dependent synthetase and ligase EO946_15225 ENOG4108IPT Naphthoate synthase EO946_15230 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EO946_15235 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EO946_15240 ENOG4105E4F Isochorismate synthase EO946_15260 ENOG4108IAJ Nad-dependent epimerase dehydratase EO946_15265 ENOG4107SBE Glycosyl transferase (Group 1 EO946_15280 ENOG4107SBE Glycosyl transferase (Group 1 EO946_15285 ENOG4108KS4 Spore coat protein EO946_15300 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EO946_15310 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EO946_15440 ENOG4105N67 Proton-coupled thiamine transporter YuaJ EO946_15445 ENOG4105VRR gCN5-related N-acetyltransferase EO946_15450 ENOG4105DZ6 Band 7 protein EO946_15460 ENOG4106DF1 EO946_15465 ENOG4108VNY MOSC domain protein EO946_15470 ENOG4108JB8 alcohol dehydrogenase EO946_15475 ENOG4105C26 Dehydrogenase EO946_15480 ENOG4105TRT Transcriptional regulator EO946_15495 ENOG4105CZN Potassium uptake protein EO946_15500 ENOG4107I77 yiaA/B two helix domain EO946_15505 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EO946_15525 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EO946_15535 ENOG4105EE0 oxidoreductase EO946_15540 ENOG4105DKG l-rhamnose isomerase EO946_15545 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) EO946_15550 ENOG4105DET Rhamnulokinase EO946_15555 ENOG4105E98 transcriptional regulator DeoR family EO946_15565 ENOG4105C8Q Methyl-accepting chemotaxis EO946_15570 ENOG4105C8Q Methyl-accepting chemotaxis EO946_15575 ENOG4105C8Q Methyl-accepting chemotaxis EO946_15580 ENOG4105C8Q Methyl-accepting chemotaxis EO946_15595 ENOG4105EA8 2-Nitropropane dioxygenase EO946_15600 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EO946_15615 ENOG4105C37 (CBS) domain EO946_15630 ENOG4107PBV potassium channel EO946_15635 ENOG4107PBV potassium channel EO946_15650 ENOG4107QYV phosphohexose isomerase EO946_15660 ENOG4107QW4 alcohol dehydrogenase EO946_15665 ENOG4105WG9 Conserved Protein EO946_15675 ENOG4105CHM Aminotransferase EO946_15680 ENOG4108ZB6 transcriptional regulator AsnC family EO946_15685 ENOG4108MUZ hydrolase EO946_15695 ENOG4105C87 Aminotransferase class I and II EO946_15700 ENOG4108HGU Histidine kinase EO946_15705 ENOG4105Y38 Kinase-associated protein B EO946_15725 ENOG4105BZ4 penicillin-binding protein EO946_15730 ENOG4105KIR Thiol-disulfide oxidoreductase dcc EO946_15745 ENOG4108MRH transcriptional regulatory protein EO946_15760 ENOG4105D65 subunit l EO946_15765 ENOG4105HC0 Na H antiporter EO946_15770 ENOG4108ZE9 Monovalent cation H antiporter subunit C EO946_15775 ENOG4108JPZ Monovalent cation H antiporter subunit D EO946_15780 ENOG4105SC1 monovalent cation H antiporter subunit E EO946_15790 ENOG4105KJM monovalent cation h antiporter subunit g EO946_15795 ENOG4105KA0 thioesterase Superfamily protein EO946_15805 ENOG4105BZU Histidine kinase EO946_15835 ENOG4105D58 Diguanylate phosphodiesterase EO946_15840 ENOG4105DAP Nicotinate phosphoribosyltransferase EO946_15865 ENOG4105C02 permease EO946_15885 ENOG410904N short-chain dehydrogenase reductase EO946_15920 ENOG4108K8K Transcriptional regulator EO946_15925 ENOG4105DCF alanine dehydrogenase EO946_15935 ENOG4105WQT MbtH domain protein EO946_15940 ENOG4105CEY Amp-dependent synthetase and ligase EO946_15945 ENOG4105WQI isochorismatase EO946_15950 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EO946_15955 ENOG4105E4F Isochorismate synthase EO946_15960 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EO946_15965 ENOG4105NIV Esterase EO946_15985 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EO946_15995 ENOG41069ER domain protein EO946_16010 ENOG4105CEP NADH dehydrogenase EO946_16015 ENOG4105CAY ferredoxin--nadp reductase EO946_16065 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 EO946_16075 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EO946_16090 ENOG4105ZKE UPF0349 protein EO946_16105 ENOG41083MR nifu domain-containing protein EO946_16110 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EO946_16115 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EO946_16120 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) EO946_16125 ENOG4105D6E homoserine dehydrogenase EO946_16135 ENOG4108W5N phosphatidylglycerophosphatase a EO946_16140 ENOG4105D4U had-superfamily hydrolase, subfamily iia EO946_16150 ENOG4105MMD transcriptional regulator EO946_16155 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) EO946_16160 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EO946_16165 ENOG4105FAA peptidase M23 EO946_16170 ENOG4108YTE sporulation protein YunB EO946_16175 ENOG4105KZD Domain of unknown function (DUF1805) EO946_16180 ENOG4107R8B 5'-nucleotidase EO946_16190 ENOG4105I3N Conserved Protein EO946_16200 ENOG4105CD3 dihydroorotase EO946_16205 ENOG4105G9B Transcriptional regulator EO946_16220 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) EO946_16225 ENOG4105VT2 5-hydroxyisourate hydrolase EO946_16240 ENOG4107YV9 domain protein EO946_16245 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding EO946_16260 ENOG4105XRQ Xanthine dehydrogenase accessory factor EO946_16265 ENOG4105C5R Aminotransferase EO946_16280 ENOG4108K8S endonuclease I EO946_16285 ENOG4108IJ9 (ABC) transporter EO946_16290 ENOG4105FDP GntR family transcriptional regulator EO946_16295 ENOG4108KPW sugar kinase EO946_16300 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EO946_16305 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EO946_16310 ENOG4105XN3 extracellular solute-binding protein family 1 EO946_16315 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine EO946_16320 ENOG4105PKS Excinuclease abc c subunit domain protein EO946_16325 ENOG4107VFR oxidoreductase EO946_16340 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase EO946_16345 ENOG4105NPE arsR family transcriptional regulator EO946_16350 ENOG4105DIW FeS assembly protein SUFB EO946_16355 ENOG4108UNV SUF system FeS assembly protein, NifU family EO946_16360 ENOG4105C9B Cysteine desulfurase EO946_16365 ENOG4105JRK feS assembly protein SufD EO946_16370 ENOG4105C3K feS assembly ATPase SufC EO946_16390 ENOG4105D01 (LipO)protein EO946_16395 ENOG4108UMI ABC transporter, permease EO946_16400 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EO946_16425 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EO946_16430 ENOG41080E8 Transcriptional regulator, Spx MgsR family EO946_16435 ENOG4105C1G acyl-Coa dehydrogenase EO946_16440 ENOG4105CHU acetyl-coa acetyltransferase EO946_16470 ENOG41067TZ transcriptional regulator, MarR family EO946_16475 ENOG4105C0R drug resistance transporter emrb qaca subfamily EO946_16480 ENOG4105MDS 4-oxalocrotonate tautomerase EO946_16490 ENOG4105EGI Transcriptional regulator EO946_16500 ENOG4105E0A ABC, transporter EO946_16515 ENOG4105E1F short-chain dehydrogenase reductase EO946_16520 ENOG4105HUF DNA protection during starvation protein EO946_16525 ENOG4105C0H protease EO946_16535 ENOG4105F3H Histidine kinase EO946_16545 ENOG41067SE Tetr family transcriptional regulator EO946_16550 ENOG4105C9Q fumarate hydratase class II EO946_16575 ENOG4105WH1 Two component transcriptional regulator luxr family EO946_16580 ENOG4105ENE Histidine kinase EO946_16595 ENOG41087YS Phage shock protein A EO946_16610 ENOG4108WBT adenosyltransferase EO946_16615 ENOG4105E0A ABC, transporter EO946_16620 ENOG4105EHG Permease protein EO946_16625 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EO946_16630 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EO946_16635 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EO946_16645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EO946_16655 ENOG4106DF4 Sigma-70, region 4 EO946_16665 ENOG4105F0F Oxalate decarboxylase EO946_16675 ENOG4107RBB ABC transporter, permease EO946_16680 ENOG4105C19 ABC transporter EO946_16685 ENOG4108WMK Efflux transporter RND family MFP subunit EO946_16690 ENOG4105E0A ABC, transporter EO946_16695 ENOG4105EHG Permease protein EO946_16700 ENOG4105DQ5 transport system permease protein EO946_16715 ENOG4105D5Q Arginine ornithine antiporter EO946_16730 ENOG4107K5X Membrane-bound metal-dependent hydrolase EO946_16735 ENOG4107QZ2 Sulfatase EO946_16740 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family EO946_16745 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EO946_16750 ENOG4105E0C molybdate abc transporter EO946_16765 ENOG4105EEQ Na H antiporter EO946_16770 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EO946_16775 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EO946_16780 ENOG4105EEM helicase EO946_16785 ENOG4105EN6 Membrane EO946_16795 ENOG4107ZQN disulfide bond EO946_16800 ENOG4105C59 p-type ATPase EO946_16805 ENOG4105C59 p-type ATPase EO946_16810 ENOG410681U heavy metal transport detoxification protein EO946_16815 ENOG4105VPX protein, conserved in bacteria EO946_16820 ENOG4105D9R oxidoreductase EO946_16825 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EO946_16830 ENOG4105ME7 Membrane EO946_16835 ENOG4105DRR Transcriptional regulator, GntR family EO946_16840 ENOG4108UZ3 Transporter EO946_16845 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EO946_16870 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EO946_16875 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EO946_16885 ENOG4105XZU Preprotein translocase, subunit SecG EO946_16910 ENOG4105KVH Transcriptional regulator EO946_16935 ENOG4105DA5 (ABC) transporter EO946_16965 ENOG4105R40 Glycine betaine carnitine choline EO946_16970 ENOG4108HQR Glycine betaine EO946_16975 ENOG4105E90 ABC transporter EO946_16980 ENOG4108IJ8 ABC transporter EO946_16985 ENOG4107HG4 Transcriptional regulator EO946_16995 ENOG4105R40 Glycine betaine carnitine choline EO946_17000 ENOG4108HQR Glycine betaine EO946_17005 ENOG4105E90 ABC transporter EO946_17010 ENOG4108IJ8 ABC transporter EO946_17015 ENOG4107HG4 Transcriptional regulator EO946_17020 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EO946_17035 ENOG4105T65 Membrane-associated protein EO946_17040 ENOG4108W0I acetyltransferase EO946_17045 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EO946_17050 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EO946_17055 ENOG4105CP7 Triose-phosphate isomerase EO946_17060 ENOG4105BZA Phosphoglycerate kinase EO946_17070 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EO946_17085 ENOG4105CMD Transcriptional regulator, GntR family EO946_17090 ENOG4105DEN Luciferase family EO946_17095 ENOG4107RT3 EamA-like transporter family EO946_17105 ENOG4105VRS hydrolase family 18 EO946_17110 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) EO946_17115 ENOG4107QR9 Iron-sulfur cluster binding protein EO946_17120 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EO946_17140 ENOG4105BZU Histidine kinase EO946_17145 ENOG4105KCT ABC transporter EO946_17150 ENOG4108M15 ABC transporter EO946_17155 ENOG4107R6F Alpha Beta Hydrolase Fold protein EO946_17160 ENOG4108MJI response regulator EO946_17175 ENOG4105EG2 ABC transporter, permease EO946_17185 ENOG4107FKK extracellular solute-binding protein family 1 EO946_17195 ENOG4105JXH GntR family transcriptional regulator EO946_17200 ENOG4105DAA L-lactate EO946_17205 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EO946_17215 ENOG4108ZPC Polysaccharide pyruvyl transferase EO946_17220 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EO946_17225 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family EO946_17230 ENOG4105D3Q Sugar transferase EO946_17240 ENOG4105K64 Glycosyl transferase, family 2 EO946_17250 ENOG4107QRS glycosyltransferase group 2 family protein EO946_17255 ENOG41068W6 Capsular polysaccharide biosynthesis protein EO946_17260 ENOG4108KMV Glycosyl transferase (Group 1 EO946_17265 ENOG4105K64 Glycosyl transferase, family 2 EO946_17270 ENOG4108PQP glycosyl transferase group 1 EO946_17280 ENOG4108QV3 biosynthesis protein EO946_17285 ENOG4105HTX biosynthesis protein EO946_17295 ENOG4105EBR Carboxylesterase EO946_17305 ENOG4105PY6 Phenolic acid decarboxylase EO946_17310 ENOG4105NI3 Protein of unknown function (DUF3237) EO946_17320 ENOG4105FQP Beta-lactamase EO946_17325 ENOG4105EDQ levansucrase EC 2.4.1.10 EO946_17330 ENOG4108HKT sucrose-6-phosphate hydrolase EO946_17335 ENOG4107QTZ amino acid EO946_17365 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EO946_17370 ENOG4108URH decarboxylase EO946_17375 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain EO946_17380 ENOG4105CHH sulfate transporter EO946_17385 ENOG4108V2W Carbonate dehydratase EO946_17390 ENOG4105C5I Dehydrogenase EO946_17400 ENOG4105C19 ABC transporter EO946_17405 ENOG4105EWM Histidine kinase EO946_17415 ENOG4107A6P EO946_17420 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EO946_17425 ENOG4105KRI phosphocarrier protein (HPr EO946_17430 ENOG4105CIE May be required for sporulation (By similarity) EO946_17435 ENOG4105CHW UPF0052 protein EO946_17440 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EO946_17445 ENOG4108Z4K mutator MutT protein EO946_17450 ENOG4105C3M thioredoxin reductase EO946_17465 ENOG4105BZ1 (ABC) transporter EO946_17475 ENOG4106FGC EO946_17485 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EO946_17490 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EO946_17495 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EO946_17500 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EO946_17505 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EO946_17510 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EO946_17515 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EO946_17520 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EO946_17530 ENOG4108E16 pectate lyase EO946_17535 ENOG4108S4C acetyltransferase EO946_17540 ENOG4107XGZ Hydrolase EO946_17545 ENOG4105HKU nucleoside recognition domain-containing protein EO946_17550 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EO946_17555 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EO946_17560 ENOG4105CE4 GlcNAc 6-P deacetylase EO946_17565 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EO946_17570 ENOG4105FDP GntR family transcriptional regulator EO946_17575 ENOG41088CQ domain protein EO946_17585 ENOG4106A3M Cytochrome p-450 EO946_17590 ENOG410625E EO946_17605 ENOG41086DT Membrane protein of unknown function EO946_17610 ENOG41067S9 phage shock protein C, PspC EO946_17615 ENOG4108PY7 EO946_17630 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EO946_17635 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EO946_17655 ENOG4105MKU Transcriptional regulator EO946_17675 ENOG4105CN1 protease EO946_17680 ENOG4105CRP Part of the ABC transporter FtsEX involved in EO946_17685 ENOG4105CAK Cell division ATP-binding protein ftsE EO946_17710 ENOG4105MS2 ribosomal subunit Interface protein EO946_17725 ENOG4105MQ3 flagellar protein FliS EO946_17730 ENOG4107RT6 flagellar hook-associated EO946_17735 ENOG41083S7 flagellar protein FlaG EO946_17740 ENOG4105I03 Flagellin EO946_17745 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EO946_17750 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) EO946_17755 ENOG4105MKD EO946_17760 ENOG4105DTJ flagellar hook-associated protein EO946_17765 ENOG4105E1Q flagellar hook-associated protein EO946_17780 ENOG4105RU3 EO946_17785 ENOG41081UC Inherit from COG: Competence protein EO946_17805 ENOG4105WH1 Two component transcriptional regulator luxr family EO946_17810 ENOG4105BZU Histidine kinase EO946_17815 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EO946_17820 ENOG4108KGH TRANSCRIPTIONal EO946_17825 ENOG4105ESV Glycosyl transferase, family 4 EO946_17830 ENOG4107EF8 Glycosyl transferase (Group 1 EO946_17845 ENOG4105QZI O-Antigen Polymerase EO946_17850 ENOG4105C6Y Udp-glucose 6-dehydrogenase EO946_17855 ENOG4107RA4 Glycosyl transferase (Group 1 EO946_17860 ENOG4105PSV Polysaccharide Biosynthesis Protein EO946_17865 ENOG4105D3Q Sugar transferase EO946_17875 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EO946_17880 ENOG4105JFG SpoIID LytB domain protein EO946_17895 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EO946_17915 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EO946_17920 ENOG4105EY8 ABC transporter EO946_17940 ENOG4107VDP teichoic acid biosynthesis EO946_17945 ENOG41088M2 Glycosyl transferase family 2 EO946_17995 ENOG4105DG6 mannose-6-phosphate isomerase EO946_18010 ENOG4108NHD germination protein EO946_18015 ENOG4105C54 Major Facilitator superfamily EO946_18020 ENOG4108KGH TRANSCRIPTIONal EO946_18025 ENOG4105J7I hydrolase EO946_18030 ENOG4105K4H Nlp p60 protein EO946_18040 ENOG4105PNM synthesis protein EO946_18050 ENOG4105N98 Capsule biosynthesis protein capB EO946_18055 ENOG4105ETE Transcriptional regulator (LacI family EO946_18060 ENOG4108RVA ribokinase EO946_18065 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EO946_18070 ENOG4105C2J ABC transporter EO946_18075 ENOG4105CNN ABC, transporter EO946_18080 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EO946_18095 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EO946_18100 ENOG4107FQX Alpha-acetolactate decarboxylase EO946_18110 ENOG4107RSM transcriptional regulator EO946_18125 ENOG4107XC4 flavin reductase domain protein, FMN-binding EO946_18135 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EO946_18145 ENOG4105CAH Chromate EO946_18150 ENOG4105FGV Chromate EO946_18160 ENOG4108WS4 fmn reductase EO946_18165 ENOG4107V2S Transcriptional regulator EO946_18175 ENOG410874W AraC family transcriptional regulator EO946_18180 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) EO946_18225 ENOG4105C6Y Udp-glucose 6-dehydrogenase EO946_18230 ENOG4108RB3 Capsular polysaccharide biosynthesis protein EO946_18235 ENOG4107YJ4 chain length determinant protein EO946_18240 ENOG4105HTX biosynthesis protein EO946_18250 ENOG4105KBK Zinc finger, swim domain protein EO946_18255 ENOG4105C0D helicase EO946_18260 ENOG410667J hydrolase EO946_18265 ENOG4105E98 transcriptional regulator DeoR family EO946_18270 ENOG4105Z8H single-stranded DNA-binding protein EO946_18295 ENOG4108VAC response regulator EO946_18305 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EO946_18310 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EO946_18320 ENOG4105CGA flagellar basal-body rod protein FlgG EO946_18330 ENOG4105DFF Rod shape-determining protein mreb EO946_18335 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EO946_18345 ENOG4107MII Sugar-specific transcriptional regulator TrmB EO946_18350 ENOG4105CZM Major Facilitator EO946_18355 ENOG4108M26 parallel beta-helix repeat protein EO946_18360 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EO946_18365 ENOG41080V3 Major Facilitator superfamily EO946_18370 ENOG4105D3W isochorismatase EO946_18375 ENOG4107P26 EO946_18380 ENOG4105BZU Histidine kinase EO946_18390 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EO946_18400 ENOG4105FRN stage II sporulation protein EO946_18405 ENOG4107TCE N-acetyltransferase EO946_18425 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EO946_18430 ENOG4107TXC Transcriptional regulator EO946_18435 ENOG4106BRK EO946_18440 ENOG4108RYK Nad-dependent epimerase dehydratase EO946_18445 ENOG4108Z40 Transcriptional regulator EO946_18450 ENOG4105CQM Urea amidohydrolase subunit alpha EO946_18455 ENOG4105KI2 Urea amidohydrolase subunit beta EO946_18460 ENOG4108YZ9 Urea amidohydrolase subunit gamma EO946_18465 ENOG4108IV0 ABC, transporter EO946_18470 ENOG4105C0Z ABC transporter EO946_18480 ENOG4105C32 Amino acid ABC transporter (Permease) EO946_18485 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein EO946_18510 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EO946_18520 ENOG4108TF4 von Willebrand factor, type A EO946_18530 ENOG4105JFG SpoIID LytB domain protein EO946_18535 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EO946_18545 ENOG4106778 Protein of unknown function (DUF1146) EO946_18560 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EO946_18565 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EO946_18570 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EO946_18575 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EO946_18595 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) EO946_18605 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EO946_18610 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EO946_18615 ENOG4108UIC UPF0340 protein EO946_18620 ENOG4108YZG isomerase EO946_18625 ENOG4107WAU Protein tyrosine phosphatase EO946_18630 ENOG410815N Probably functions as a manganese efflux pump (By similarity) EO946_18635 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EO946_18645 ENOG4108ZXQ stage ii sporulation protein r EO946_18660 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EO946_18665 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EO946_18670 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EO946_18680 ENOG4107TT2 Auxin Efflux Carrier EO946_18685 ENOG4105C6K Malic enzyme EO946_18690 ENOG4107104 thymidine kinase EO946_18695 ENOG41082DI 50s ribosomal protein l31 EO946_18700 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EO946_18710 ENOG4105CBT Fructose-1,6-bisphosphatase EO946_18715 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EO946_18720 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway EO946_18725 ENOG4105D2N Aldolase EO946_18730 ENOG410812K response regulator receiver protein EO946_18740 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EO946_18750 ENOG4105C1G acyl-Coa dehydrogenase EO946_18755 ENOG4105DF6 Fe-S oxidoreductase EO946_18765 ENOG4105E5J UV damage endonuclease EO946_18775 ENOG4105NAE bifunctional deaminase-reductase domain protein EO946_18780 ENOG4105BZ1 (ABC) transporter EO946_18785 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EO946_18800 ENOG4105R3A Nitrate reductase EO946_18805 ENOG4108IUE nitrate reductase beta subunit EO946_18825 ENOG4107V6Q Cyclic nucleotide-binding domain EO946_18835 ENOG4105C75 arginyL-tRNA synthetase EO946_18840 ENOG410684U Domain of unknown function (DUF1934) EO946_18850 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E EO946_18895 ENOG4107JM4 Tetratricopeptide repeat EO946_18905 ENOG4105CYW agmatinase EO946_18910 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EO946_18915 ENOG4105BZ4 penicillin-binding protein EO946_18925 ENOG4108XFG YwhD family EO946_18930 ENOG4108Z4T Peptidase M50 EO946_18935 ENOG41069HH 4-oxalocrotonate tautomerase EO946_18940 ENOG41067TZ transcriptional regulator, MarR family EO946_18945 ENOG4105C22 threonyL-tRNA synthetase EO946_18960 ENOG4105DCI Phosphohydrolase EO946_18970 ENOG4108VCI transcription factor, rsfa family EO946_18975 ENOG4108RNG Permease of the drug metabolite transporter EO946_18980 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) EO946_18985 ENOG4105DUM transcriptional regulator, lysR family EO946_18990 ENOG4108IJ2 phosphate acetyltransferase EO946_19005 ENOG4105CHM Aminotransferase EO946_19015 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase EO946_19020 ENOG4105CHR reductase EO946_19025 ENOG4106CHD Bacilysin biosynthesis protein bacB EO946_19030 ENOG41061WN bacilysin biosynthesis protein EO946_19035 ENOG4105FCW Major Facilitator superfamily EO946_19050 ENOG4105C26 Dehydrogenase EO946_19055 ENOG4105D82 Glutamate dehydrogenase EO946_19065 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase EO946_19070 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EO946_19075 ENOG4105C1B dTDP-glucose 4-6-dehydratase EO946_19080 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EO946_19085 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG EO946_19090 ENOG4107TY6 Acylneuraminate cytidylyltransferase EO946_19100 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD EO946_19105 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EO946_19145 ENOG4105C26 Dehydrogenase EO946_19150 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EO946_19155 ENOG4108RJ9 Glycosyl transferase, family 2 EO946_19175 ENOG4105DWF phosphomethylpyrimidine kinase EO946_19190 ENOG4105C5Y PTS System EO946_19195 ENOG4108QTI )-transporter EO946_19210 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EO946_19215 ENOG4105DEN Luciferase family EO946_19220 ENOG4108DBC nitroreductase EO946_19260 ENOG4107BMA Transglycosylase associated protein EO946_19270 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) EO946_19275 ENOG4105WH5 Teichoic acid glycosylation protein EO946_19300 ENOG4107ZXU DSBA oxidoreductase EO946_19305 ENOG4105DBE peroxidase EO946_19310 ENOG410650H (LipO)protein EO946_19315 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EO946_19325 ENOG4105CMU LysR family (Transcriptional regulator EO946_19330 ENOG4105VAW lrga family EO946_19335 ENOG41067MG lrgb family EO946_19340 ENOG4108RDQ ABC transporter EO946_19365 ENOG41067MG lrgb family EO946_19370 ENOG4105D8G Major Facilitator superfamily EO946_19380 ENOG4105DR4 Methyltransferase EO946_19390 ENOG4108YV3 Protein of unknown function (DUF2711) EO946_19395 ENOG4105CK1 PTS System EO946_19405 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin EO946_19425 ENOG4105X1N Glycosyl transferase family 8 EO946_19435 ENOG4105GVJ transcriptional regulator EO946_19440 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EO946_19445 ENOG4105IIU Aminopeptidase EO946_19460 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EO946_19470 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) EO946_19475 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EO946_19485 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EO946_19490 ENOG4108VHC Short-chain dehydrogenase reductase Sdr EO946_19495 ENOG4105CM2 brancheD-chain amino acid aminotransferase EO946_19500 ENOG4105F8D glycoside hydrolase family 4 EO946_19505 ENOG4105VCP PTS System EO946_19510 ENOG4105CK1 PTS System EO946_19515 ENOG4105VZJ PTS System EO946_19520 ENOG4105EMD TRANSCRIPTIONal EO946_19530 ENOG4108VX5 3-methyladenine DNA glycosylase EO946_19535 ENOG4105CH6 catalase EO946_19550 ENOG4105DA5 (ABC) transporter EO946_19555 ENOG41069JR EO946_19575 ENOG4105ETS cytosine purines uracil thiamine allantoin EO946_19580 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EO946_19585 ENOG4108JJ8 (ABC) transporter EO946_19590 ENOG4108JJ9 ABC, transporter EO946_19595 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EO946_19600 ENOG4105C4M (Ubiquinol oxidase) subunit I EO946_19605 ENOG4105D2K citrate carrier protein EO946_19620 ENOG4107BJW polysaccharide deacetylase EO946_19650 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EO946_19660 ENOG4105CMR udp-glucose 4-epimerase EO946_19670 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EO946_19695 ENOG4105DTD Dehydrogenase EO946_19700 ENOG4108IIH CoA-transferase subunit B EO946_19705 ENOG4105D6N CoA-transferase, subunit a EO946_19710 ENOG4105CY2 Citrate transporter EO946_19715 ENOG4105DHI Methyltransferase EO946_19735 ENOG4105CH6 catalase EO946_19740 ENOG4105D4T Citrate transporter EO946_19745 ENOG410900G Protein of unknown function (DUF421) EO946_19755 ENOG4105CS2 ec 3.2.1.21 EO946_19760 ENOG4105C5Y PTS System EO946_19765 ENOG4105CID antiterminator EO946_19775 ENOG4105DEU major facilitator superfamily EO946_19780 ENOG4105C1J atp-dependent rna helicase EO946_19785 ENOG4107TDE lipolytic protein G-D-S-L family EO946_19910 ENOG4107TS3 membrane protein, TerC EO946_19915 ENOG4107YZX Universal stress protein EO946_19920 ENOG4105CS2 ec 3.2.1.21 EO946_19925 ENOG4105C5Y PTS System EO946_19960 ENOG4107EV6 Inherit from COG: YD repeat protein EO946_19975 ENOG4106Z5D Glycoside Hydrolase Family 43 EO946_19980 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EO946_19990 ENOG4105C84 Histidine ammonia-lyase EO946_19995 ENOG4105CGP Urocanate hydratase EO946_20000 ENOG4105CI2 imidazolone-5-propionate hydrolase EO946_20005 ENOG4107W25 arginase agmatinase formiminoglutamase EO946_20015 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EO946_20020 ENOG4105D9N nucleoside EO946_20030 ENOG4107RHR regulatoR EO946_20035 ENOG4108TM9 integral membrane protein EO946_20040 ENOG4105ENY Ethanolamine utilization protein eutH EO946_20045 ENOG4108PGP mmge prpd family protein EO946_20050 ENOG4105CH2 amidohydrolase EO946_20060 ENOG4108HW4 amino acid AbC transporter EO946_20065 ENOG4105EAB amino acid AbC transporter EO946_20070 ENOG4108XSB acetyltransferase, (GNAT) family EO946_20075 ENOG4105CPU Monooxygenase EO946_20080 ENOG4107QHE Choloylglycine hydrolase EO946_20085 ENOG410667J hydrolase EO946_20115 ENOG4108V5C ABC transporter EO946_20145 ENOG4105D2N Aldolase EO946_20150 ENOG4107TRN Xylose isomerase domain protein TIM barrel EO946_20155 ENOG4105F0H myo-inositol catabolism protein EO946_20160 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EO946_20170 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EO946_20175 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EO946_20180 ENOG4105D7K pfkb domain protein EO946_20190 ENOG4105C26 Dehydrogenase EO946_20200 ENOG4105CPC Aldo Keto reductase EO946_20215 ENOG4107QNK )-transporter EO946_20220 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EO946_20230 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EO946_20240 ENOG4105ST3 Transcriptional regulator EO946_20245 ENOG4105C26 Dehydrogenase EO946_20260 ENOG41085PJ rdd domain containing protein EO946_20275 ENOG4105J7D transcriptional regulator EO946_20280 ENOG4107JEE Short-chain dehydrogenase reductase Sdr EO946_20285 ENOG41061AU MarR family Transcriptional regulator EO946_20295 ENOG41067MG lrgb family EO946_20310 ENOG4105BZW Glycerate kinase EO946_20315 ENOG4105G3Z GntR family transcriptional regulator EO946_20320 ENOG4105CMG Carbohydrate kinase EO946_20325 ENOG4105C6Z Gluconate EO946_20330 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EO946_20335 ENOG4105D3R alkyl hydroperoxide reductase EO946_20340 ENOG4108JU3 Alkyl hydroperoxide reductase EO946_20350 ENOG4105CS2 ec 3.2.1.21 EO946_20360 ENOG4108S3Y transcriptional regulator EO946_20370 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 EO946_20375 ENOG4105DVF Cytosine-specific methyltransferase EO946_20400 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EO946_20425 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) EO946_20430 ENOG4105WQG acetyltransferase EO946_20435 ENOG410780I phosphoprotein phosphatase activity EO946_20445 ENOG41066UZ arginase EC 3.5.3.1 EO946_20450 ENOG4108IQI permease EO946_20455 ENOG4105C8Y Acetylornithine aminotransferase EO946_20460 ENOG4108JUB Transcriptional regulator EO946_20470 ENOG4105C0H protease EO946_20475 ENOG4105Q2H domain protein EO946_20490 ENOG4105BZU Histidine kinase EO946_20495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EO946_20520 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EO946_20525 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EO946_20530 ENOG4105CDU Replicative dna helicase EO946_20550 ENOG4105DJ2 Major Facilitator Superfamily EO946_20555 ENOG4105EDW glycosyl transferase, family 39 EO946_20560 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EO946_20565 ENOG4105BZR domain protein EO946_20570 ENOG4108XMW Membrane EO946_20585 ENOG4105KVH Transcriptional regulator EO946_20590 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase EO946_20620 ENOG4105D94 Major Facilitator Superfamily EO946_20625 ENOG4107RSM transcriptional regulator EO946_20630 ENOG41082BV acetyltransferase EO946_20635 ENOG41081I9 integral membrane protein EO946_20650 ENOG41079CX EO946_20655 ENOG4108U05 Transcriptional regulator EO946_20660 ENOG41082BV acetyltransferase EO946_20670 ENOG4105C7Z Conserved Protein EO946_20675 ENOG4107FCW Abortive infection protein EO946_20685 ENOG4108UW5 maltose o-acetyltransferase EO946_20690 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase EO946_20700 ENOG4105CGK Exodeoxyribonuclease III EO946_20705 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EO946_20710 ENOG4108UUM single-stranded DNA-binding protein EO946_20715 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EO946_20720 ENOG4105C3G gtp-binding protein EO946_20725 ENOG4108J2R molybdopterin oxidoreductase EO946_20730 ENOG4105VDK protein, conserved in bacteria EO946_20740 ENOG4108ZDA Sporulation protein YyaC EO946_20745 ENOG4105FA0 parb-like partition protein EO946_20750 ENOG4107QJE Chromosome Partitioning Protein EO946_20765 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EO946_20770 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EO946_20775 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EO946_20790 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)