locus-tag class description GYO_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GYO_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GYO_0003 ENOG410848D S4 domain protein YaaA GYO_0006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GYO_0008 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GYO_0013 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GYO_0015 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GYO_0016 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GYO_0017 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GYO_0019 ENOG4105ZMH deoxynucleoside kinase GYO_0022 ENOG4105GTG Isochorismatase GYO_0023 ENOG4108Z6B deaminase GYO_0024 ENOG4105C6E dna polymerase iii GYO_0025 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GYO_0026 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GYO_0028 ENOG41067KS pro-sigma K processing GYO_0035 ENOG4105CDW Resistance protein GYO_0036 ENOG4105CXN decarboxylase GYO_0037 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GYO_0038 ENOG4105X0R protein from nitrogen regulatory protein P-II GYO_0039 ENOG4105XVJ Protein of unknown function (DUF327) GYO_0040 ENOG4105FA2 dna polymerase iii GYO_0041 ENOG4105MA4 psp1 domain protein GYO_0042 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) GYO_0043 ENOG41060K3 Methyltransferase GYO_0044 ENOG4105VC4 domain protein GYO_0045 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GYO_0046 ENOG4105KRN Transcriptional regulator, abrb family GYO_0047 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GYO_0048 ENOG4105F8V Hydrolase, tatD family GYO_0049 ENOG41069ER domain protein GYO_0051 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GYO_0052 ENOG4105XFA sporulation peptidase YabG GYO_0053 ENOG4105W42 Veg protein GYO_0054 ENOG4105XEW small acid-soluble spore protein GYO_0055 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GYO_0056 ENOG4105DFT pur operon repressor GYO_0057 ENOG4105KME endoribonuclease L-psp GYO_0058 ENOG4105K4W Could be involved in septation (By similarity) GYO_0062 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GYO_0063 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GYO_0064 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GYO_0066 ENOG4108JA2 transcriptioN-repair coupling factor GYO_0067 ENOG4108M14 stage v sporulation protein t GYO_0069 ENOG4108IY2 MazG family GYO_0070 ENOG41082I2 s4 domain protein GYO_0071 ENOG4105VYY sporulation protein yabp GYO_0074 ENOG41060GV RNA binding s1 domain protein GYO_0080 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GYO_0081 ENOG4108UGV hypoxanthine phosphoribosyltransferase GYO_0082 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GYO_0084 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GYO_0085 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase GYO_0086 ENOG4105C6T cysteine synthase GYO_0089 ENOG4105DDQ anthranilate synthase GYO_0090 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GYO_0091 ENOG4105EEI dihydropteroate synthase GYO_0092 ENOG4105KRF dihydroneopterin aldolase GYO_0093 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GYO_0095 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GYO_0096 ENOG4105CRK lysyL-tRNA synthetase GYO_0110 ENOG4108Z0C Uvrb UvrC protein GYO_0111 ENOG41066A3 ATP guanido phosphotransferase GYO_0113 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GYO_0114 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GYO_0115 ENOG4105CTP PilT protein domain protein GYO_0116 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GYO_0117 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GYO_0118 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GYO_0121 ENOG4105D7W serine acetyltransferase GYO_0122 ENOG4105C8N cysteinyl-tRNA synthetase GYO_0123 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) GYO_0124 ENOG4105C2N RNA methyltransferase TrmH family group 3 GYO_0125 ENOG4105M0M Tetracycline resistance protein GYO_0128 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GYO_0129 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GYO_0131 ENOG4108VZM 50s ribosomal protein L10 GYO_0132 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GYO_0133 ENOG4107Y49 methyltransferase GYO_0134 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GYO_0135 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GYO_0136 ENOG4105XPM ribosomal protein GYO_0137 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GYO_0138 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GYO_0139 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GYO_0140 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GYO_0141 ENOG4107SKW Inherit from COG: Alpha beta hydrolase GYO_0142 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GYO_0143 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GYO_0144 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GYO_0145 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GYO_0146 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GYO_0147 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GYO_0148 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GYO_0149 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GYO_0150 ENOG41082SA 50s ribosomal protein l29 GYO_0151 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GYO_0152 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GYO_0154 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GYO_0156 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GYO_0157 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GYO_0158 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GYO_0159 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GYO_0160 ENOG4105VPB 50S ribosomal protein L30 GYO_0161 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GYO_0162 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GYO_0164 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GYO_0167 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GYO_0168 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GYO_0169 ENOG4108ZT0 50S ribosomal protein l17 GYO_0170 ENOG4108JJB ABC transporter GYO_0173 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GYO_0174 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GYO_0175 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GYO_0176 ENOG4108UJD 30S ribosomal protein S9 GYO_0178 ENOG4108I0C methyltransferase GYO_0181 ENOG4105D1F ATP-binding protein GYO_0184 ENOG4108NMV polysaccharide deacetylase GYO_0190 ENOG410635T phage-like element pbsx protein GYO_0192 ENOG41067QW Transcriptional regulator GYO_0202 ENOG4105CDU Replicative dna helicase GYO_0203 ENOG4105QBX endodeoxyribonuclease RusA GYO_0210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYO_0223 ENOG4105IG6 Phage terminase, large subunit GYO_0224 ENOG4108MDF Phage Portal Protein GYO_0225 ENOG4106CGH Phage Mu protein F like protein GYO_0232 ENOG41060SN GYO_0235 ENOG4105PQS phage protein GYO_0236 ENOG4105FR7 XkdM protein, phage-like element PBSX GYO_0237 ENOG4105MTC XkdN-like protein GYO_0239 ENOG4108FKH Transglycosylase SLT domain GYO_0240 ENOG4108WZM domain protein GYO_0241 ENOG4105X7F GYO_0243 ENOG4105MFU Protein of unknown function (DUF2634) GYO_0244 ENOG41066EA baseplate J family protein GYO_0245 ENOG410906S phage-like element pbsx protein xkdt GYO_0247 ENOG41068G1 GYO_0252 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GYO_0269 ENOG410635T phage-like element pbsx protein GYO_0271 ENOG41067QW Transcriptional regulator GYO_0281 ENOG4105CDU Replicative dna helicase GYO_0282 ENOG4105QBX endodeoxyribonuclease RusA GYO_0289 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYO_0302 ENOG4105IG6 Phage terminase, large subunit GYO_0303 ENOG4108MDF Phage Portal Protein GYO_0304 ENOG4106CGH Phage Mu protein F like protein GYO_0311 ENOG41060SN GYO_0314 ENOG4105PQS phage protein GYO_0315 ENOG4105FR7 XkdM protein, phage-like element PBSX GYO_0316 ENOG4105MTC XkdN-like protein GYO_0318 ENOG4108FKH Transglycosylase SLT domain GYO_0319 ENOG4108WZM domain protein GYO_0320 ENOG4105X7F GYO_0322 ENOG4105MFU Protein of unknown function (DUF2634) GYO_0323 ENOG41066EA baseplate J family protein GYO_0324 ENOG410906S phage-like element pbsx protein xkdt GYO_0326 ENOG41068G1 GYO_0331 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GYO_0346 ENOG4108JPW Aminotransferase GYO_0348 ENOG4105CPQ Dehydrogenase GYO_0349 ENOG4105CHH sulfate transporter GYO_0351 ENOG4108SA1 esterase GYO_0355 ENOG410874W AraC family transcriptional regulator GYO_0357 ENOG4105EHZ conserved protein UCP016719 GYO_0358 ENOG4105D17 glycoside hydrolase, family 3 domain protein GYO_0362 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GYO_0364 ENOG4105EWC Purine nucleoside phosphorylase GYO_0370 ENOG4105EMN RNA polymerase sigma factor GYO_0372 ENOG4105C8B TIGR00159 family GYO_0373 ENOG4107U5W ybbr family GYO_0374 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GYO_0376 ENOG4108TWJ NADH dehydrogenase subunit 5 GYO_0380 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GYO_0382 ENOG4105WAB arsR family transcriptional regulator GYO_0383 ENOG4108RWP Major Facilitator Superfamily protein GYO_0386 ENOG4108Z6Z Transcriptional regulator GYO_0392 ENOG4105G0J serine threonine protein kinase GYO_0394 ENOG4106K80 GYO_0396 ENOG4106DDH Sporulation-specific SASP protein GYO_0398 ENOG4108HWY Beta-lactamase GYO_0400 ENOG4107E6A Cytochrome p-450 GYO_0403 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GYO_0404 ENOG4105CXY transporter GYO_0407 ENOG410645S MarR family Transcriptional regulator GYO_0408 ENOG4105DCM major facilitator superfamily GYO_0413 ENOG4106AXJ AraC family transcriptional regulator GYO_0417 ENOG4105NVB glycoside hydrolase, family 19 GYO_0418 ENOG4105GIG GYO_0422 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GYO_0423 ENOG4108TCS Glutamyl endopeptidase GYO_0425 ENOG4108WC5 Alpha Beta Hydrolase Fold protein GYO_0426 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GYO_0431 ENOG4105C72 UPF0176 protein GYO_0433 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane GYO_0434 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GYO_0435 ENOG4108X79 transcriptional regulator GYO_0437 ENOG4105CM2 brancheD-chain amino acid aminotransferase GYO_0438 ENOG4108IQI permease GYO_0439 ENOG4108J5H Homocysteine s-methyltransferase GYO_0441 ENOG4105CSV Glutaminase GYO_0445 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GYO_0446 ENOG4105C26 Dehydrogenase GYO_0447 ENOG4105DJB Major Facilitator Superfamily GYO_0448 ENOG4105EQX glucarate dehydratase GYO_0449 ENOG41073TP transcriptional regulator GYO_0450 ENOG4105CTX dehydratase GYO_0453 ENOG4106UX7 integral membrane protein GYO_0454 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GYO_0461 ENOG4105MUA Resistance protein GYO_0463 ENOG4105DGI Alkaline phosphatase GYO_0464 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GYO_0465 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GYO_0466 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GYO_0467 ENOG4107EPV Aminotransferase class V GYO_0468 ENOG4105C0R drug resistance transporter emrb qaca subfamily GYO_0469 ENOG4105J7D transcriptional regulator GYO_0470 ENOG4107RB3 L-asparaginase GYO_0471 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold GYO_0473 ENOG41060AI SEC-C motif GYO_0475 ENOG4107Y7X LytTR GYO_0476 ENOG4108IUW ABC transporter GYO_0477 ENOG4108SDH ABC, transporter GYO_0478 ENOG4107SET aldo keto reductase GYO_0485 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GYO_0488 ENOG4105DSE periplasmic solute binding protein GYO_0489 ENOG4105DIK (ABC) transporter GYO_0492 ENOG4105DEN Luciferase family GYO_0493 ENOG4108N0M stress protein GYO_0494 ENOG4106FN3 tellurium resistance protein GYO_0495 ENOG4106FN3 tellurium resistance protein GYO_0496 ENOG4107TS3 membrane protein, TerC GYO_0497 ENOG4108TTB tellurium resistance protein GYO_0499 ENOG41079KZ Major Facilitator Superfamily GYO_0500 ENOG4107XZQ multidrug resistance protein GYO_0501 ENOG4108A65 Transcriptional regulator GYO_0502 ENOG4108IJ7 Glycine betaine GYO_0503 ENOG4107SQ8 Glycine betaine GYO_0516 ENOG4105EIG urea carboxylase-associated protein 1 GYO_0517 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GYO_0518 ENOG4105I1F Resistance protein GYO_0520 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GYO_0521 ENOG41089UC methyltransferase, type 11 GYO_0522 ENOG4105C5Q Transcriptional regulator GYO_0523 ENOG4105I82 acetyl xylan esterase GYO_0524 ENOG410756H nucleotidyltransferase GYO_0528 ENOG4105CK7 Sodium proline symporter GYO_0529 ENOG4107YHD transcriptional regulator GYO_0531 ENOG4108PJD permease GYO_0532 ENOG4105U6C Alpha beta hydrolase fold protein GYO_0535 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GYO_0536 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GYO_0537 ENOG4108IFG nitrite reductase, (NAD(P)H) GYO_0538 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GYO_0542 ENOG4105S7A ErfK ybiS ycfS ynhG family protein GYO_0544 ENOG4105CKI cobalamin synthesis protein GYO_0545 ENOG4105E5Q amino acid AbC transporter GYO_0546 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein GYO_0549 ENOG4105HHM rdd domain containing protein GYO_0551 ENOG4105K56 Transcriptional regulator GYO_0553 ENOG4108VEN abc transporter atp-binding protein GYO_0554 ENOG4105CS2 ec 3.2.1.21 GYO_0557 ENOG4105C8Q Methyl-accepting chemotaxis GYO_0558 ENOG41080HJ 6-phospho 3-hexuloisomerase GYO_0559 ENOG4108VA3 3-hexulose-6-phosphate synthase GYO_0560 ENOG4105KVH Transcriptional regulator GYO_0568 ENOG4105SX7 Transporter GYO_0570 ENOG4105W8Z 4'-phosphopantetheinyl transferase GYO_0574 ENOG4105CDA abc transporter atp-binding protein GYO_0575 ENOG4105DRP amino acid AbC transporter GYO_0577 ENOG4106P55 Transcriptional regulator GYO_0578 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GYO_0579 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GYO_0580 ENOG41069ZX GYO_0581 ENOG41069ZX GYO_0583 ENOG4105DUX Transporter GYO_0586 ENOG4105E1K spore germination protein GYO_0590 ENOG4107WD8 ABC transporter, permease GYO_0591 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYO_0592 ENOG4105BZU Histidine kinase GYO_0595 ENOG4105CFH Aspartokinase GYO_0596 ENOG4105DHS permease protein GYO_0597 ENOG4105CM4 permease protein GYO_0598 ENOG4108IPW abc transporter atp-binding protein GYO_0601 ENOG4105R8C Transcriptional regulator GYO_0602 ENOG4108DBC nitroreductase GYO_0603 ENOG41067V3 Antibiotic biosynthesis monooxygenase GYO_0604 ENOG4105YVS arsR family transcriptional regulator GYO_0606 ENOG4108JPW Aminotransferase GYO_0607 ENOG4105C26 Dehydrogenase GYO_0610 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GYO_0611 ENOG4105KTB nuclear export factor GLE1 GYO_0612 ENOG4108T5E Copper resistance protein GYO_0613 ENOG4108ZYE Transcriptional regulator GYO_0618 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GYO_0623 ENOG4105E7W lamb ycsf family protein GYO_0624 ENOG4105C5A transporter GYO_0625 ENOG4105CFM UPF0317 protein GYO_0626 ENOG4105P4J Allophanate hydrolase, subunit 1 GYO_0628 ENOG4107258 Transcriptional regulator GYO_0629 ENOG4105XJB lipolytic protein G-D-S-L family GYO_0631 ENOG41061CK Antibiotic biosynthesis monooxygenase GYO_0632 ENOG4107RVG penicillin-binding protein GYO_0633 ENOG4107QM2 Aldo Keto reductase GYO_0634 ENOG4105ETD TRANSCRIPTIONal GYO_0636 ENOG4105HMZ Methyltransferase GYO_0637 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GYO_0640 ENOG410606W general stress protein GYO_0642 ENOG4105VCH membrane GYO_0644 ENOG4105C9U ATP-dependent DNA helicase RecQ GYO_0647 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GYO_0648 ENOG4107R8N Glycosyl transferase, family 2 GYO_0650 ENOG4105C0X amino acid GYO_0655 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GYO_0657 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) GYO_0658 ENOG4105EU9 GYO_0659 ENOG4105QVS general stress protein GYO_0660 ENOG41082W1 Cupin 2, conserved barrel domain protein GYO_0663 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GYO_0664 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GYO_0665 ENOG4108MRH transcriptional regulatory protein GYO_0666 ENOG4107QJT sodium dicarboxylate symporter GYO_0667 ENOG4106F5Q Membrane GYO_0669 ENOG4105CJ1 ABC, transporter GYO_0672 ENOG4105FDT acyl-CoA dehydrogenase GYO_0676 ENOG4105SZ6 Thioredoxin GYO_0677 ENOG4105CPF Cell wall formation (By similarity) GYO_0678 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GYO_0679 ENOG4105C1J atp-dependent rna helicase GYO_0680 ENOG410905X membrane-flanked domain protein GYO_0681 ENOG4105CKV Membrane GYO_0683 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GYO_0685 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GYO_0687 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GYO_0688 ENOG4107MMM Anti-sigma-factor antagonist GYO_0689 ENOG4105FUA antagonist GYO_0690 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GYO_0691 ENOG4107SGM protein serine threonine phosphatase GYO_0692 ENOG4105WN5 stage II sporulation protein GYO_0693 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GYO_0695 ENOG41064BQ Phosphatase GYO_0707 ENOG4108RWP Major Facilitator Superfamily protein GYO_0708 ENOG4105EMU Dehydrogenase GYO_0710 ENOG4105ENX hydrolase GYO_0711 ENOG4105ST3 Transcriptional regulator GYO_0712 ENOG4106ANW SMI1_KNR4 GYO_0716 ENOG4105M4P Tetr family transcriptional regulator GYO_0718 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GYO_0719 ENOG4105DEN Luciferase family GYO_0721 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GYO_0722 ENOG4108HH4 Major Facilitator Superfamily GYO_0723 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GYO_0724 ENOG4105DJ2 Major Facilitator Superfamily GYO_0725 ENOG4107RSM transcriptional regulator GYO_0726 ENOG4108RPX mosc domain containing protein GYO_0727 ENOG4105N14 lysine exporter protein LysE YggA GYO_0730 ENOG4105ECK Fatty Acid Desaturase GYO_0732 ENOG4105VEQ Cold shock protein GYO_0733 ENOG4108VJ1 Transcriptional regulator (CarD family GYO_0738 ENOG4105DJ2 Major Facilitator Superfamily GYO_0739 ENOG4108IMY Transcriptional regulator GYO_0740 ENOG41086D8 Transcriptional regulator GYO_0742 ENOG4105CZ9 Domain of unknown function (DU1801) GYO_0745 ENOG4105GIG GYO_0746 ENOG4105DTD Dehydrogenase GYO_0747 ENOG4105KRI phosphocarrier protein (HPr GYO_0748 ENOG4105ST3 Transcriptional regulator GYO_0750 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GYO_0752 ENOG4105T38 integral membrane protein GYO_0753 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GYO_0754 ENOG4108ZMQ domain protein GYO_0755 ENOG4105MJ9 esterase GYO_0757 ENOG4105KVH Transcriptional regulator GYO_0758 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GYO_0760 ENOG41082YX Transcriptional regulator, arsr family GYO_0761 ENOG4107R5R arsenical pump membrane protein GYO_0762 ENOG4108UXE Protein tyrosine phosphatase GYO_0763 ENOG4105Z7P Acetyltransferase (GNAT) family GYO_0764 ENOG4108KGH TRANSCRIPTIONal GYO_0765 ENOG4108ZJ4 polysaccharide deacetylase GYO_0767 ENOG4105BZU Histidine kinase GYO_0768 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYO_0769 ENOG4107Y9U Membrane GYO_0771 ENOG4108SQ9 flavin reductase domain protein, FMN-binding GYO_0772 ENOG4108ZHR arsR family transcriptional regulator GYO_0773 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GYO_0776 ENOG4105ENE Histidine kinase GYO_0777 ENOG4108VB1 regulatoR GYO_0778 ENOG4105EYF MMPL domain protein GYO_0784 ENOG4108UQV Membrane GYO_0785 ENOG4108Z5V transcriptional regulator, merr family GYO_0786 ENOG41076HS cation diffusion facilitator family transporter GYO_0787 ENOG4108TVJ Nitroreductase GYO_0788 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GYO_0789 ENOG4108VGI doxx family GYO_0790 ENOG4105XXY Thioredoxin GYO_0802 ENOG4105PF9 Transcriptional regulator GYO_0804 ENOG4105WQG acetyltransferase GYO_0807 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GYO_0808 ENOG4105ETE Transcriptional regulator (LacI family GYO_0809 ENOG4105C54 Major Facilitator superfamily GYO_0810 ENOG4107TRE AP endonuclease, family 2 GYO_0811 ENOG4105F27 Major Facilitator GYO_0814 ENOG4105C85 amino acid GYO_0816 ENOG41062A4 Transcriptional regulator GYO_0817 ENOG4105EYF MMPL domain protein GYO_0818 ENOG4108TVJ Nitroreductase GYO_0819 ENOG4105FS7 Transcriptional regulator GYO_0820 ENOG4108JCI Transcriptional regulator GYO_0824 ENOG4105C2C drug resistance transporter, Bcr CflA GYO_0826 ENOG4105DQ6 Transposase GYO_0828 ENOG4105DRR Transcriptional regulator, GntR family GYO_0829 ENOG4105VRS hydrolase family 18 GYO_0832 ENOG4105G6Z alkaline phosphatase GYO_0835 ENOG4108YM7 Gcn5-related n-acetyltransferase GYO_0836 ENOG4107TVP HD domain protein GYO_0837 ENOG41090UD (LipO)protein GYO_0838 ENOG4105F27 Major Facilitator GYO_0839 ENOG4105VZJ PTS System GYO_0840 ENOG4105VCP PTS System GYO_0841 ENOG4105CK1 PTS System GYO_0842 ENOG4105CS2 ec 3.2.1.21 GYO_0843 ENOG4108TZY GntR Family Transcriptional Regulator GYO_0844 ENOG4105EVU fructokinase GYO_0845 ENOG4105DG6 mannose-6-phosphate isomerase GYO_0846 ENOG4105D3P Mannan endo-1,4-beta-mannosidase GYO_0853 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GYO_0854 ENOG4105K8N protein family UPF0079, ATPase GYO_0855 ENOG41072GX Peptidase M22 Glycoprotease GYO_0856 ENOG410801F ribosomal-protein-alanine acetyltransferase GYO_0857 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GYO_0859 ENOG4105C5H ABC transporter GYO_0860 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GYO_0861 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GYO_0862 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GYO_0863 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GYO_0865 ENOG4108TYN CAAX amino terminal protease family protein GYO_0866 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GYO_0867 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GYO_0870 ENOG4105PGZ NB-ARC domain GYO_0871 ENOG4105CPQ Dehydrogenase GYO_0872 ENOG4105CT4 transporter GYO_0874 ENOG41087YS Phage shock protein A GYO_0875 ENOG4105DQX Zinc finger domain GYO_0876 ENOG4108WV1 Pfam:DUF477 GYO_0878 ENOG4108ZMR Ion transport 2 domain-containing protein GYO_0879 ENOG4107QNK )-transporter GYO_0885 ENOG4107YUH hydrolase GYO_0890 ENOG4105C85 amino acid GYO_0892 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GYO_0897 ENOG4105C7N Xanthine uracil vitamin C permease GYO_0902 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GYO_0903 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GYO_0904 ENOG4105C83 adenylosuccinate lyase GYO_0905 ENOG4105C8V SAICAR synthetase GYO_0906 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GYO_0907 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GYO_0908 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GYO_0910 ENOG4105CXB phosphoribosylaminoimidazole synthetase GYO_0911 ENOG4108V3E phosphoribosylglycinamide formyltransferase GYO_0912 ENOG4105DC1 bifunctional purine biosynthesis protein purh GYO_0913 ENOG4105C12 Phosphoribosylglycinamide synthetase GYO_0915 ENOG4105DVH amino acid GYO_0918 ENOG4108R5T secreted protein GYO_0919 ENOG4105KGF protein, YerC YecD GYO_0920 ENOG4105CBC glutamate synthase GYO_0922 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) GYO_0923 ENOG4105C4R Atp-dependent dna helicase GYO_0924 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GYO_0926 ENOG4105CRN Aminoglycoside phosphotransferase GYO_0927 ENOG4105KT7 mgtC SapB transporter GYO_0928 ENOG4105CK7 Sodium proline symporter GYO_0930 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GYO_0931 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GYO_0932 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GYO_0933 ENOG4108IG5 Transcriptional regulator GYO_0935 ENOG4105CBD Diacylglycerol kinase GYO_0936 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GYO_0941 ENOG4108HFV GYO_0945 ENOG4105CDY transcriptional regulatory protein GYO_0947 ENOG4105M4P Tetr family transcriptional regulator GYO_0948 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein GYO_0949 ENOG4107S9F NmrA family GYO_0952 ENOG4105WEF catalase GYO_0953 ENOG4105M18 -acetyltransferase GYO_0955 ENOG4105C2F Histidine kinase GYO_0956 ENOG4105EQD regulatoR GYO_0957 ENOG410769Z extracellular solute-binding protein family 1 GYO_0958 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GYO_0959 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GYO_0960 ENOG4105F5H Glycosyl Hydrolase Family 88 GYO_0961 ENOG41075H3 AraC family transcriptional regulator GYO_0962 ENOG4107TDE lipolytic protein G-D-S-L family GYO_0965 ENOG4105CX8 fg-gap repeat protein GYO_0966 ENOG4105CX8 fg-gap repeat protein GYO_0967 ENOG4107TDE lipolytic protein G-D-S-L family GYO_0969 ENOG4105EKC GYO_0970 ENOG4105E0S extracellular solute-binding protein family 1 GYO_0972 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GYO_0973 ENOG4105F8D glycoside hydrolase family 4 GYO_0974 ENOG4105H67 Protein of unknown function (DUF421) GYO_0975 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GYO_0976 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GYO_0980 ENOG4106I4J membrane GYO_0981 ENOG4108PCN EamA-like transporter family GYO_0982 ENOG41082F9 transcriptional regulator GYO_0983 ENOG41061H0 Monooxygenase GYO_0984 ENOG4106H3A restriction GYO_0985 ENOG4108R1P GYO_0986 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GYO_0987 ENOG4105E0M Sulfatase GYO_0989 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GYO_0991 ENOG41090R9 glycosyltransferase GYO_0993 ENOG41090R9 glycosyltransferase GYO_0994 ENOG4105EU0 Major facilitator Superfamily GYO_0997 ENOG4105CUB amino acid GYO_0998 ENOG4105C26 Dehydrogenase GYO_1000 ENOG4105C5H ABC transporter GYO_1002 ENOG4107SWG transcriptional regulator MERR family GYO_1003 ENOG4105DXB Major Facilitator superfamily GYO_1007 ENOG4105C5H ABC transporter GYO_1008 ENOG4105FDU atp-dependent rna helicase GYO_1010 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GYO_1013 ENOG4105E6M Sulphatase-modifying factor protein GYO_1014 ENOG4105E0A ABC, transporter GYO_1015 ENOG4108U1V ABC transporter, permease GYO_1016 ENOG4105DQ5 transport system permease protein GYO_1017 ENOG4108HUF Transporter GYO_1020 ENOG4108J20 pectate lyase GYO_1021 ENOG4107QPK )-transporter GYO_1024 ENOG4108MRH transcriptional regulatory protein GYO_1030 ENOG410855V Acylphosphatase GYO_1031 ENOG4108RPX mosc domain containing protein GYO_1036 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) GYO_1041 ENOG4105GEU Spore germination protein GYO_1044 ENOG4105E1K spore germination protein GYO_1045 ENOG4105C5Y PTS System GYO_1046 ENOG4105CG3 alpha amylase, catalytic region GYO_1047 ENOG4107414 GntR family transcriptional regulator GYO_1048 ENOG4108RCM Nitroreductase GYO_1049 ENOG4105CGH 5'-nucleotidase GYO_1051 ENOG4107RKG DJ-1/PfpI family GYO_1055 ENOG4105KJF protein tyrosine phosphatase GYO_1057 ENOG4107U9T Pfam:Ribonuclease_BN GYO_1058 ENOG4108ISG Major Facilitator GYO_1059 ENOG4105UPD Calcium Proton GYO_1061 ENOG4105D8X mechanosensitive ion channel GYO_1065 ENOG4106KE4 Dehydrogenase GYO_1066 ENOG4105D7N magnesium and cobalt transport protein CorA GYO_1068 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GYO_1070 ENOG4105KNA -acetyltransferase GYO_1075 ENOG4107RUY (E1 component), alpha subunit GYO_1077 ENOG4107QKR Dehydrogenase GYO_1079 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GYO_1080 ENOG41069DP small acid-soluble spore protein GYO_1081 ENOG4105KK4 UPF0060 membrane protein GYO_1086 ENOG4105F8D glycoside hydrolase family 4 GYO_1087 ENOG4108Q3X Transcriptional regulator GYO_1088 ENOG4105CI1 PTS System GYO_1089 ENOG4105BZ1 (ABC) transporter GYO_1090 ENOG4105BZ1 (ABC) transporter GYO_1092 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GYO_1093 ENOG4105ID8 Transcriptional regulator, ARAC family GYO_1094 ENOG4107QNK )-transporter GYO_1095 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GYO_1096 ENOG4105CIB oxidoreductase Domain protein GYO_1097 ENOG4105BZU Histidine kinase GYO_1098 ENOG4105WH1 Two component transcriptional regulator luxr family GYO_1100 ENOG4105CJ1 ABC, transporter GYO_1101 ENOG41090VJ ABC-2 type transporter GYO_1102 ENOG4108KYE ABC-2 type transporter GYO_1104 ENOG4105U3E Transcriptional regulator GYO_1105 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold GYO_1106 ENOG4105H93 Acyltransferase family GYO_1108 ENOG4108YYS metal-dependent hydrolase (By similarity) GYO_1109 ENOG4105C0R drug resistance transporter emrb qaca subfamily GYO_1110 ENOG410834F Transcriptional regulator GYO_1112 ENOG4108MES Periplasmic binding protein GYO_1113 ENOG4105DQ5 transport system permease protein GYO_1114 ENOG4108IHU transport system permease protein GYO_1116 ENOG4105JAB phenazine biosynthesis protein, phzf family GYO_1117 ENOG4107Y03 Nitroreductase GYO_1119 ENOG4105ECP epimerase GYO_1122 ENOG4105F27 Major Facilitator GYO_1126 ENOG4106AKJ GYO_1127 ENOG4105D74 hydrolase GYO_1128 ENOG4105CKK Glycosyl transferase, family 2 GYO_1129 ENOG4105EJV Membrane GYO_1130 ENOG41067AE Membrane-bound metal-dependent hydrolase GYO_1131 ENOG4105CEN a g-specific adenine glycosylase GYO_1132 ENOG4106BXE GYO_1133 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GYO_1136 ENOG4105EVI UPF0374 protein GYO_1137 ENOG4105BZ1 (ABC) transporter GYO_1138 ENOG4107NBY Membrane GYO_1140 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GYO_1141 ENOG4105G5W regulator Fur family GYO_1161 ENOG4108N23 SpoOM-related protein GYO_1164 ENOG4105EC3 peptidase S51, dipeptidase E GYO_1166 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GYO_1169 ENOG4105E2Y ABC, transporter GYO_1170 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein GYO_1171 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GYO_1172 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GYO_1174 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GYO_1175 ENOG4107D63 GYO_1176 ENOG4105VZ8 Transcriptional regulator GYO_1179 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GYO_1181 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GYO_1186 ENOG4105CYN Serine protein kinase GYO_1187 ENOG4106AKX UPF0229 protein GYO_1188 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GYO_1189 ENOG4105CW7 secretion protein, HlyD family GYO_1190 ENOG4105C0R drug resistance transporter emrb qaca subfamily GYO_1191 ENOG4105CS1 NAD(P)H quinone oxidoreductase GYO_1194 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GYO_1195 ENOG4105CZV ABC transporter GYO_1196 ENOG4105CJ1 ABC, transporter GYO_1197 ENOG4108TU7 Inherit from COG: (ABC) transporter GYO_1198 ENOG4105VEQ Cold shock protein GYO_1200 ENOG4105BZU Histidine kinase GYO_1208 ENOG4108YBP pseudouridine synthase GYO_1210 ENOG41080XP Cbs domain GYO_1211 ENOG4107YBY Hydrolase GYO_1212 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GYO_1214 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GYO_1215 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GYO_1217 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GYO_1218 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GYO_1220 ENOG4105BZU Histidine kinase GYO_1221 ENOG4105WH1 Two component transcriptional regulator luxr family GYO_1229 ENOG4105G6Z alkaline phosphatase GYO_1232 ENOG4105BZN citrate synthase GYO_1233 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GYO_1234 ENOG4105CUB amino acid GYO_1236 ENOG4105C8J )-transporter GYO_1237 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GYO_1240 ENOG4105J37 GYO_1241 ENOG4108AEY RNA polymerase sigma factor GYO_1242 ENOG4108FN7 Aldo keto reductase GYO_1243 ENOG4105F6E Acyl-transferase GYO_1244 ENOG4107VFR oxidoreductase GYO_1246 ENOG4105C37 (CBS) domain GYO_1248 ENOG4105CHM Aminotransferase GYO_1250 ENOG4105C37 (CBS) domain GYO_1252 ENOG4105WMR Protein CrcB homolog GYO_1253 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GYO_1255 ENOG4105D64 Mechanosensitive ion channel GYO_1256 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GYO_1257 ENOG4107VMI polysaccharide deacetylase GYO_1258 ENOG4105F0I Aminotransferase GYO_1262 ENOG4105BZ1 (ABC) transporter GYO_1263 ENOG4105BZ1 (ABC) transporter GYO_1269 ENOG410839P GYO_1271 ENOG4106MP8 UPF0754 membrane protein GYO_1272 ENOG4105WZB UPF0342 protein GYO_1273 ENOG4105F1N DNA alkylation repair GYO_1275 ENOG4105D4P Coproporphyrinogen iii oxidase GYO_1276 ENOG4107S91 Sodium hydrogen exchanger GYO_1277 ENOG4105NCW Trka-c domain protein GYO_1279 ENOG4105CGU Enoyl-CoA hydratase GYO_1281 ENOG4108IUX (ABC) transporter GYO_1282 ENOG4105RHA ABC transporter, permease GYO_1283 ENOG4107VRP DNA repair exonuclease GYO_1284 ENOG4106D4I domain protein GYO_1285 ENOG4105EQI Metal Dependent Phosphohydrolase GYO_1287 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GYO_1295 ENOG4105NBU tryptophan transport protein GYO_1296 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GYO_1297 ENOG4105K59 histidine triad (HIT) protein GYO_1305 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GYO_1306 ENOG4105BZ4 penicillin-binding protein GYO_1307 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GYO_1309 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GYO_1310 ENOG4105C1Q protoporphyrinogen oxidase GYO_1312 ENOG4105ECB domain protein GYO_1314 ENOG41090T1 Membrane GYO_1318 ENOG4105DER m42 family GYO_1321 ENOG4106AXD GYO_1322 ENOG4108RQ5 Beta-lactamase domain-containing protein GYO_1323 ENOG4105DF9 Lipoate-protein, ligase GYO_1325 ENOG4105CEY Amp-dependent synthetase and ligase GYO_1327 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GYO_1328 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GYO_1331 ENOG4105KD7 acetyltransferase GYO_1335 ENOG4108HUF Transporter GYO_1336 ENOG4107TB6 phosphoglycerate mutase GYO_1338 ENOG4107F3J Amp-dependent synthetase and ligase GYO_1339 ENOG4107ZYJ bioY protein GYO_1340 ENOG4106YBV Methyl-accepting chemotaxis GYO_1344 ENOG4105XVF Competence transcription factor GYO_1345 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GYO_1347 ENOG4105X3H Excalibur domain protein GYO_1348 ENOG4105E1V na solute symporter GYO_1349 ENOG4106CAD Protein of unknown function (DUF3311) GYO_1350 ENOG41060YP GYO_1353 ENOG4107SCK Monooxygenase GYO_1354 ENOG4108INS Transcriptional regulator GYO_1358 ENOG4105TRI Hydrolase GYO_1361 ENOG4108KK1 membrane protein AbrB duplication GYO_1362 ENOG4106K7D Major facilitator family transporter GYO_1363 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GYO_1367 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GYO_1369 ENOG4105EYH Exonuclease GYO_1380 ENOG4105ERH Fumarylacetoacetate hydrolase GYO_1382 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GYO_1384 ENOG4105CAQ asparagine synthetase GYO_1388 ENOG4105UQX Mate efflux family protein GYO_1389 ENOG4106HBX Transcriptional Regulator AraC Family GYO_1390 ENOG4105ETE Transcriptional regulator (LacI family GYO_1391 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GYO_1392 ENOG4105SF0 DinB family GYO_1393 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GYO_1394 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GYO_1395 ENOG4105MYW Pentapeptide repeat protein GYO_1396 ENOG4107S9D Alpha beta hydrolase GYO_1397 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GYO_1398 ENOG4107RIQ Sulfate adenylate transferase GYO_1399 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GYO_1400 ENOG4108N5B 2-phosphosulfolactate phosphatase GYO_1401 ENOG41061P3 phosphosulfolactate synthase GYO_1403 ENOG4105DIA mandelate racemase muconate lactonizing GYO_1404 ENOG4107RCC Major Facilitator Superfamily GYO_1405 ENOG4108SZE gCN5-related N-acetyltransferase GYO_1406 ENOG4105MA6 gCN5-related N-acetyltransferase GYO_1408 ENOG4108VPT UPF0234 protein GYO_1409 ENOG4105QNR S1 RNA binding domain protein GYO_1410 ENOG410751J GYO_1411 ENOG4105EPR degv family GYO_1412 ENOG4107AYK membrAne GYO_1414 ENOG41073B9 GYO_1416 ENOG4108KP7 hydrolase GYO_1417 ENOG4108MXZ Esterase GYO_1418 ENOG4105VG1 fes assembly suf system protein GYO_1423 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GYO_1426 ENOG4105C8Y Acetylornithine aminotransferase GYO_1427 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GYO_1429 ENOG4105DBV ornithine carbamoyltransferase GYO_1434 ENOG4107RMD Basic membrane lipoprotein GYO_1437 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GYO_1438 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GYO_1440 ENOG4105C3U ABC transporter GYO_1441 ENOG4108JQ7 (ABC) transporter GYO_1444 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYO_1446 ENOG4105C31 Tryptophanyl-tRNA synthetase GYO_1447 ENOG4108J59 Extracellular solute-binding protein, family 5 GYO_1448 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GYO_1449 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYO_1451 ENOG4108JQ7 (ABC) transporter GYO_1454 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GYO_1455 ENOG4108ZCF integral membrane protein GYO_1456 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis GYO_1458 ENOG4105DPN Oligoendopeptidase f GYO_1460 ENOG4105T58 Dithiol-disulfide isomerase GYO_1461 ENOG4108Z18 K06886 hemoglobin GYO_1462 ENOG4105E4C Lytic transglycosylase catalytic GYO_1463 ENOG4105MIX Adenylate cyclase GYO_1466 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GYO_1467 ENOG4105EMS pseudouridine synthase GYO_1470 ENOG4105ETU transcriptional activator (TenA GYO_1471 ENOG4108VEU Thiamine monophosphate synthase GYO_1474 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GYO_1475 ENOG4105D06 uba thif-type nad fad binding protein GYO_1476 ENOG4105DWF phosphomethylpyrimidine kinase GYO_1477 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GYO_1478 ENOG4107A88 GYO_1489 ENOG4105ENA helicase GYO_1492 ENOG4108ZMI UPF0477 protein GYO_1494 ENOG4105C28 cystathionine GYO_1495 ENOG4105C28 cystathionine GYO_1496 ENOG4105D9U N-acetyltransferase GYO_1504 ENOG4105DM4 PTS System GYO_1505 ENOG4105DG6 mannose-6-phosphate isomerase GYO_1507 ENOG4105VMI -acetyltransferase GYO_1509 ENOG4108Z66 YbaK ebsC protein GYO_1513 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GYO_1515 ENOG4108ZJ4 polysaccharide deacetylase GYO_1516 ENOG4107CUJ Protein of unknown function (DUF2690) GYO_1523 ENOG4108IEG Formate dehydrogenase Alpha subunit GYO_1528 ENOG4106A3M Cytochrome p-450 GYO_1529 ENOG41087PP glycosyltransferase MGT family GYO_1531 ENOG4105EXQ uroporphyrinogen iii synthase hem4 GYO_1532 ENOG4105C4B ABC transporter, permease GYO_1533 ENOG4108IXI (ABC) transporter GYO_1535 ENOG4105Q95 Cupin 2, conserved barrel domain protein GYO_1539 ENOG4105D2H Uronic isomerase GYO_1540 ENOG4105CT4 transporter GYO_1541 ENOG4105DG4 malate L-lactate dehydrogenase GYO_1542 ENOG4105CPQ Dehydrogenase GYO_1543 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GYO_1544 ENOG4105DMW Dehydrogenase reductase GYO_1545 ENOG4108I5G Major Facilitator superfamily GYO_1546 ENOG4107KJX Transcriptional regulator GYO_1547 ENOG4107QZW Altronate oxidoreductase GYO_1548 ENOG4105CTX dehydratase GYO_1549 ENOG4107TSN permease GYO_1551 ENOG4105JD4 ATPase yjob GYO_1554 ENOG41068K0 YCII-related domain GYO_1556 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GYO_1557 ENOG4105KWG Pfam:DUF1696 GYO_1558 ENOG4105K7W phage-related replication protein GYO_1559 ENOG4105WEF catalase GYO_1560 ENOG410635T phage-like element pbsx protein GYO_1569 ENOG4108TFU terminase (Small subunit) GYO_1570 ENOG4105IG6 Phage terminase, large subunit GYO_1571 ENOG4108MDF Phage Portal Protein GYO_1576 ENOG41060SN GYO_1579 ENOG4105PQS phage protein GYO_1580 ENOG4105FR7 XkdM protein, phage-like element PBSX GYO_1581 ENOG4105MTC XkdN-like protein GYO_1583 ENOG4108FKH Transglycosylase SLT domain GYO_1583 ENOG4108FKH Transglycosylase SLT domain GYO_1583 ENOG4108FKH Transglycosylase SLT domain GYO_1584 ENOG4108WZM domain protein GYO_1585 ENOG4105X7F GYO_1587 ENOG4105MFU Protein of unknown function (DUF2634) GYO_1588 ENOG41066EA baseplate J family protein GYO_1589 ENOG410906S phage-like element pbsx protein xkdt GYO_1591 ENOG41068G1 GYO_1597 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GYO_1601 ENOG4105CJ3 phosphate transporter GYO_1602 ENOG4107GRR phosphate transport regulator GYO_1603 ENOG4107R7I amino acid GYO_1606 ENOG4105EDW glycosyl transferase, family 39 GYO_1607 ENOG4105CKK Glycosyl transferase, family 2 GYO_1609 ENOG4105C0H protease GYO_1611 ENOG4108ME1 Peptidase M55 D-aminopeptidase GYO_1612 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GYO_1613 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYO_1614 ENOG4105C3U ABC transporter GYO_1616 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GYO_1617 ENOG4105DTQ mandelate racemase muconate lactonizing GYO_1618 ENOG4107SN7 NLP P60 protein GYO_1619 ENOG4108JQ7 (ABC) transporter GYO_1620 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GYO_1621 ENOG4107TUM Amidinotransferase GYO_1622 ENOG4108S4H thioesterase Superfamily protein GYO_1623 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GYO_1627 ENOG4108428 Inherit from COG: -acetyltransferase GYO_1629 ENOG41080TC multidrug resistance protein GYO_1630 ENOG4105CIY formyltetrahydrofolate deformylase GYO_1631 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GYO_1634 ENOG4105K56 Transcriptional regulator GYO_1635 ENOG4108ZHJ Organic hydroperoxide resistance protein GYO_1636 ENOG4107TVC Glycosyl transferase, family 2 GYO_1637 ENOG4107Y2X deaminase GYO_1639 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GYO_1641 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GYO_1644 ENOG4108W7F transporter, permease GYO_1645 ENOG4108JJB ABC transporter GYO_1646 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein GYO_1647 ENOG4108X43 YKOF domain protein GYO_1648 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYO_1651 ENOG4106849 propeptide, pepSY amd peptidase M4 GYO_1654 ENOG4105CJW magnesium transporter GYO_1655 ENOG4105V75 Transcriptional regulator GYO_1664 ENOG4105DQE DNA ligase GYO_1665 ENOG4105FDF Could be involved in DNA repair (By similarity) GYO_1666 ENOG4105BZU Histidine kinase GYO_1668 ENOG4107T5V SNARE associated Golgi GYO_1669 ENOG4107TS3 membrane protein, TerC GYO_1670 ENOG4108WZW RNA polymerase sigma GYO_1672 ENOG410681C small acid-soluble spore protein GYO_1674 ENOG4105D0M Protease HtpX homolog GYO_1678 ENOG4108TGC Acyltransferase GYO_1679 ENOG4105BZU Histidine kinase GYO_1680 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GYO_1682 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GYO_1683 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GYO_1684 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GYO_1686 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit GYO_1687 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) GYO_1688 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GYO_1689 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GYO_1694 ENOG4105BZU Histidine kinase GYO_1695 ENOG41090MY MarR family Transcriptional regulator GYO_1696 ENOG4105ER2 Ompa motb domain protein GYO_1697 ENOG4105E14 MotA TolQ exbB proton channel GYO_1700 ENOG4108K88 Membrane GYO_1701 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GYO_1702 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase GYO_1703 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GYO_1704 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GYO_1713 ENOG4105F0V Cell wall hydrolase GYO_1717 ENOG4105C59 p-type ATPase GYO_1719 ENOG4105DC7 peptidase M24 GYO_1722 ENOG4105CID antiterminator GYO_1724 ENOG4105KRI phosphocarrier protein (HPr GYO_1725 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GYO_1727 ENOG4105F6S Spore photoproduct lyase GYO_1729 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GYO_1730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GYO_1731 ENOG4105K4I Scp-like extracellular GYO_1733 ENOG4105BZU Histidine kinase GYO_1734 ENOG4105CHM Aminotransferase GYO_1737 ENOG4107R88 Chemotaxis protein (CheV) GYO_1738 ENOG4105UIN GYO_1740 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GYO_1742 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GYO_1743 ENOG4105EPM Diguanylate phosphodiesterase GYO_1745 ENOG4107IN1 Protein of unknown function (DUF1797) GYO_1746 ENOG4108XRC Protein of unknown function (DUF458) GYO_1752 ENOG4105NQC Flavodoxin GYO_1754 ENOG4105CH2 amidohydrolase GYO_1756 ENOG4105D8X mechanosensitive ion channel GYO_1757 ENOG4105D3R alkyl hydroperoxide reductase GYO_1758 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GYO_1762 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GYO_1763 ENOG4105D06 uba thif-type nad fad binding protein GYO_1764 ENOG4105CVM Molybdenum cofactor synthesis domain protein GYO_1765 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GYO_1766 ENOG4108ZAF Molybdopterin GYO_1767 ENOG41067WU Molybdopterin converting factor (Subunit 1) GYO_1768 ENOG4105BZ1 (ABC) transporter GYO_1769 ENOG4105BZ1 (ABC) transporter GYO_1771 ENOG4107X8C Efflux transporter RND family MFP subunit GYO_1772 ENOG4105C19 ABC transporter GYO_1773 ENOG4107RBB ABC transporter, permease GYO_1774 ENOG4105E98 transcriptional regulator DeoR family GYO_1775 ENOG4105DE4 1-phosphofructokinase GYO_1776 ENOG4105DM4 PTS System GYO_1777 ENOG4105C3F Signal peptidase i GYO_1779 ENOG4105C5H ABC transporter GYO_1780 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GYO_1785 ENOG4105BZU Histidine kinase GYO_1787 ENOG4107ZYR domain protein GYO_1789 ENOG4105CN5 Metallo-Beta-Lactamase GYO_1792 ENOG4108X4Q Hydrolase GYO_1793 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GYO_1798 ENOG4105CPP Dehydrogenase, E1 component GYO_1799 ENOG4105C7S Dehydrogenase GYO_1800 ENOG4107QN2 dihydrolipoyl dehydrogenase GYO_1804 ENOG4105CXN decarboxylase GYO_1805 ENOG4105WBI UPF0223 protein GYO_1808 ENOG4105ECY inositol monophosphatase GYO_1810 ENOG4105JQZ Methyltransferase GYO_1819 ENOG4105CI3 gtp-binding protein typa GYO_1820 ENOG4105QA2 GYO_1823 ENOG4108IAB Phoh family GYO_1825 ENOG4105CSV Glutaminase GYO_1826 ENOG4105ZPI UPF0358 protein GYO_1827 ENOG4105CNI cell division protein FtsW GYO_1828 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GYO_1831 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GYO_1834 ENOG4105BZ9 Cytochrome C oxidase, subunit I GYO_1835 ENOG4105CCU oxidase (Subunit III) GYO_1836 ENOG41064X9 cytochrome C oxidase subunit IV GYO_1839 ENOG41080XQ Signal transduction protein with cbs domains GYO_1840 ENOG4106UY4 Inherit from COG: Scp-like extracellular GYO_1845 ENOG4105WUC UPF0298 protein GYO_1846 ENOG4106H78 methyltransferase GYO_1847 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GYO_1848 ENOG4105H20 Sporulation integral membrane protein YlbJ GYO_1849 ENOG4105D78 K07001 NTE family protein GYO_1850 ENOG41063PX domain protein GYO_1851 ENOG4105CDE UPF0348 protein GYO_1853 ENOG4105KNH Nucleic acid-binding protein GYO_1859 ENOG4108V6E Cell division protein mraZ GYO_1860 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GYO_1862 ENOG4105CJN penicillin-binding protein GYO_1863 ENOG4105CJN penicillin-binding protein GYO_1864 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GYO_1865 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GYO_1866 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GYO_1867 ENOG4105CNI cell division protein FtsW GYO_1868 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GYO_1869 ENOG4105D4A Cell wall formation (By similarity) GYO_1870 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GYO_1871 ENOG4108R2U division initiation protein GYO_1873 ENOG4105K67 small basic protein GYO_1874 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GYO_1875 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GYO_1878 ENOG4105FFI sigma-e processing peptidase spoiiga GYO_1879 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYO_1881 ENOG4105DKW ABC transporter GYO_1883 ENOG4105WR5 sporulation protein, YlmC YmxH family GYO_1885 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GYO_1886 ENOG4105DFA alanine racemase domain protein GYO_1887 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GYO_1888 ENOG41067XK integral membrane protein GYO_1889 ENOG4105DBK s4 domain protein GYO_1892 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GYO_1894 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GYO_1895 ENOG4105C34 Pseudouridine synthase GYO_1896 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GYO_1898 ENOG4105CXT aspartate transcarbamylase GYO_1900 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GYO_1901 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GYO_1902 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GYO_1903 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GYO_1904 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GYO_1905 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GYO_1906 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GYO_1908 ENOG4107S4M Sulfate adenylate transferase GYO_1909 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GYO_1910 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GYO_1911 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GYO_1912 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GYO_1913 ENOG4105F23 Fibronectin-binding protein GYO_1915 ENOG4105DSJ YicC domain protein GYO_1916 ENOG4105KC4 UPF0296 protein GYO_1917 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GYO_1919 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GYO_1921 ENOG4105C25 Primosomal protein n' GYO_1922 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GYO_1923 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GYO_1925 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GYO_1926 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GYO_1927 ENOG4108ZF3 Phosphatase GYO_1928 ENOG4105D9P serine threonine protein kinase GYO_1929 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GYO_1930 ENOG4105DJV ribulose-phosphate 3-epimerase GYO_1931 ENOG4105FJ0 thiamine GYO_1932 ENOG4105VB9 50S ribosomal protein l28 GYO_1933 ENOG4108ZAA Alkaline-shock protein GYO_1934 ENOG4105DP4 dak2 domain fusion protein ylov GYO_1936 ENOG4105EJQ L-serine dehydratase GYO_1937 ENOG4105CB5 ATP-dependent DNA helicase recG GYO_1938 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GYO_1940 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GYO_1941 ENOG4105CHR reductase GYO_1942 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GYO_1943 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GYO_1944 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GYO_1945 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GYO_1947 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GYO_1949 ENOG4105K5M 30s ribosomal protein S16 GYO_1950 ENOG4108BW8 UPF0109 protein GYO_1952 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GYO_1953 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GYO_1954 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GYO_1956 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GYO_1960 ENOG4105VM1 flagellar GYO_1961 ENOG4105CMV Succinyl-CoA synthetase subunit beta GYO_1962 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GYO_1964 ENOG4105C79 DNA protecting protein DprA GYO_1966 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GYO_1967 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GYO_1968 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GYO_1969 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GYO_1970 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GYO_1972 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GYO_1973 ENOG4108ZC9 flagellar basal-body rod protein flgc GYO_1974 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GYO_1975 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GYO_1976 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GYO_1979 ENOG4106YF4 Flagellar biosynthesis chaperone GYO_1981 ENOG410696Y Flagellar hook-length control protein GYO_1982 ENOG410822I Flagellar hook capping protein GYO_1983 ENOG4108JQA flagellar GYO_1984 ENOG41068WV flagellar FlbD family protein GYO_1986 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GYO_1987 ENOG4105DD5 Flagellar motor switch protein GYO_1988 ENOG4107YTP response regulator receiver protein GYO_1990 ENOG4105CN7 Flagellar biosynthetic protein FliP GYO_1991 ENOG4105VS8 Flagellar biosynthetic protein fliq GYO_1992 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GYO_1993 ENOG4105D00 flagellar biosynthetic protein flhB GYO_1994 ENOG4105D7B Flagellar biosynthesis protein flha GYO_1995 ENOG4105FZW flagellar biosynthesis regulator FlhF GYO_1997 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GYO_1998 ENOG4105CBS Chea signal transduction histidine kinase GYO_1999 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis GYO_2002 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYO_2004 ENOG4105CE9 30S ribosomal protein S2 GYO_2005 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GYO_2007 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GYO_2008 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GYO_2009 ENOG4105KNE Phosphatidate cytidylyltransferase GYO_2011 ENOG4105DZP Membrane-associated zinc metalloprotease GYO_2012 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GYO_2013 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GYO_2014 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GYO_2015 ENOG4105CHV Transcription elongation factor NusA GYO_2016 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GYO_2017 ENOG4105VHM ribosomal protein GYO_2019 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GYO_2020 ENOG4105W7A Protein of unknown function (DUF503) GYO_2021 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GYO_2023 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GYO_2024 ENOG4105DTN riboflavin biosynthesis protein ribF GYO_2025 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GYO_2027 ENOG4105C1V Peptidase, M16 GYO_2029 ENOG4105E35 Dipicolinate synthase subunit A GYO_2030 ENOG4108S0H Dipicolinic acid synthetase, b subunit GYO_2031 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GYO_2033 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GYO_2035 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GYO_2037 ENOG4105CNU cell division protein FtsK GYO_2038 ENOG4105FDP GntR family transcriptional regulator GYO_2042 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GYO_2043 ENOG4105XZV Protein of unknown function (DUF3243) GYO_2046 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GYO_2047 ENOG4105CEV competence damage-inducible protein GYO_2049 ENOG4108A04 Beta-lactamase GYO_2050 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GYO_2051 ENOG4105D48 metallophosphoesterase GYO_2052 ENOG4105MCT stage V sporulation protein S GYO_2055 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GYO_2056 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GYO_2060 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GYO_2062 ENOG4105IIP Membrane GYO_2063 ENOG4105W1N transcriptional regulator GYO_2064 ENOG4108151 Beta-lactamase domain protein GYO_2065 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GYO_2067 ENOG4107QKG PfaD family GYO_2068 ENOG41062T2 Acyl carrier protein GYO_2069 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase GYO_2070 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GYO_2071 ENOG4108MGH Enoyl-CoA hydratase GYO_2072 ENOG4108KQ6 Enoyl-CoA hydratase GYO_2073 ENOG4105C0W non-ribosomal peptide synthetase GYO_2074 ENOG4107SQU synthase GYO_2076 ENOG4105C0W non-ribosomal peptide synthetase GYO_2078 ENOG4106A3M Cytochrome p-450 GYO_2082 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GYO_2085 ENOG4105K7W phage-related replication protein GYO_2086 ENOG4108X3M OsmC Ohr family protein GYO_2091 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GYO_2092 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GYO_2096 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GYO_2097 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GYO_2098 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GYO_2099 ENOG4105U6W MutT NUDIX family protein GYO_2100 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GYO_2102 ENOG4106F1P AAA ATPase, central domain protein GYO_2103 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GYO_2104 ENOG4105CXI aluminum resistance protein GYO_2105 ENOG4105KV4 Transcriptional regulator GYO_2106 ENOG4105C5F glutamine synthetase GYO_2111 ENOG4105CT4 transporter GYO_2112 ENOG4105DSG hydrolase family 43 GYO_2115 ENOG4105CMG Carbohydrate kinase GYO_2117 ENOG4107Y9E nuclease GYO_2119 ENOG4105C54 Major Facilitator superfamily GYO_2120 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GYO_2124 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GYO_2138 ENOG4105CAH Chromate GYO_2140 ENOG4108Q8B Spore germination protein GYO_2141 ENOG4108NHD germination protein GYO_2144 ENOG4105FVX GYO_2147 ENOG4105K7W phage-related replication protein GYO_2150 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GYO_2152 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GYO_2154 ENOG4108SVB resolvase GYO_2155 ENOG4105VPS UPF0291 protein GYO_2156 ENOG4105CV1 Transketolase (EC 2.2.1.1) GYO_2161 ENOG4107QIV Cytochrome c biogenesis protein GYO_2168 ENOG4108I0Z Aconitate hydratase GYO_2169 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GYO_2172 ENOG41067CD Small, acid-soluble spore protein Tlp GYO_2174 ENOG4105MI2 GYO_2175 ENOG4105W8X HesB YadR YfhF-family protein GYO_2176 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GYO_2177 ENOG4105K4P CoA-binding domain protein GYO_2178 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GYO_2183 ENOG4107QWR cellulase (EC 3.2.1.4) GYO_2186 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GYO_2187 ENOG4107T5V SNARE associated Golgi GYO_2189 ENOG4107QX3 carboxylase GYO_2190 ENOG4105E39 Enoyl-CoA hydratase GYO_2191 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GYO_2192 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GYO_2193 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GYO_2194 ENOG4105CEY Amp-dependent synthetase and ligase GYO_2195 ENOG4105C1G acyl-Coa dehydrogenase GYO_2198 ENOG4105F32 YngK protein GYO_2199 ENOG4106U2H Protein of unknown function (DUF1360) GYO_2204 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family GYO_2205 ENOG4108N2V aldose 1-epimerase GYO_2206 ENOG4107QJQ Mate efflux family protein GYO_2212 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GYO_2213 ENOG4105SKE transcriptional Regulator LysR family GYO_2214 ENOG4105CB2 alcohol dehydrogenase GYO_2215 ENOG4105BZ8 glutamate synthase GYO_2216 ENOG4105CBC glutamate synthase GYO_2217 ENOG4105C5Q Transcriptional regulator GYO_2218 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GYO_2225 ENOG4108UB7 GYO_2230 ENOG4105CJ1 ABC, transporter GYO_2232 ENOG4105IE8 Alpha-ketoglutarate permease GYO_2233 ENOG4107U6E carbohydrate kinase FGGY GYO_2234 ENOG4108M3J Dehydrogenase GYO_2235 ENOG4108J2R molybdopterin oxidoreductase GYO_2241 ENOG4105EC8 Methyl-accepting chemotaxis GYO_2243 ENOG4108YQE rare lipoprotein a GYO_2244 ENOG4105XPP Protein of unknown function (DUF1275) GYO_2245 ENOG4108NR7 pectate lyase GYO_2246 ENOG4105CHR reductase GYO_2249 ENOG4108RAV Conserved protein GYO_2251 ENOG4105F0F Oxalate decarboxylase GYO_2256 ENOG41073R8 VanW family GYO_2258 ENOG4105VMP Transcriptional regulator GYO_2259 ENOG4105NX3 Membrane GYO_2261 ENOG4108Q5Y Membrane GYO_2267 ENOG4108V4B ThiJ pfpI GYO_2268 ENOG4108J4B Beta-lactamase GYO_2271 ENOG4108M1A Chitin-binding protein GYO_2275 ENOG4107T94 Endo-14-beta-xylanase GYO_2279 ENOG4108RZ2 Glycoside hydrolase family 16 GYO_2286 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GYO_2287 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GYO_2288 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GYO_2294 ENOG4108UW5 maltose o-acetyltransferase GYO_2298 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GYO_2302 ENOG4108Z7R Chaperone CsaA GYO_2303 ENOG4105FTV AraC Family Transcriptional Regulator GYO_2307 ENOG4108W8B Beta-lactamase domain protein GYO_2309 ENOG4105D29 Helix-turn-helix type 11 domain protein GYO_2311 ENOG4105KTU Transcriptional regulator, arsr family GYO_2313 ENOG4108SJC Membrane GYO_2318 ENOG4105ECK Fatty Acid Desaturase GYO_2320 ENOG4108ZGX Histidine kinase GYO_2321 ENOG4108S01 response regulator GYO_2322 ENOG4107RUZ Sss sodium solute transporter superfamily GYO_2325 ENOG41069ER domain protein GYO_2326 ENOG4105C9U ATP-dependent DNA helicase RecQ GYO_2327 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GYO_2328 ENOG4105SCY DNAK suppressor GYO_2333 ENOG4105C26 Dehydrogenase GYO_2334 ENOG4105EWU Squalene--hopene cyclase GYO_2335 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GYO_2336 ENOG4105C8J )-transporter GYO_2337 ENOG4105C09 Bile acid GYO_2338 ENOG4105C7S Dehydrogenase GYO_2340 ENOG4107T89 von Willebrand factor, type A GYO_2341 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GYO_2343 ENOG4105K4H Nlp p60 protein GYO_2344 ENOG41087PP glycosyltransferase MGT family GYO_2346 ENOG4107QMU Mate efflux family protein GYO_2347 ENOG4106SCS STAS domain GYO_2351 ENOG4105FR1 rard protein GYO_2354 ENOG4105C6Z Gluconate GYO_2356 ENOG41090U3 tautomerase GYO_2360 ENOG4105FBA Phospholipase Carboxylesterase GYO_2363 ENOG4105E1V na solute symporter GYO_2367 ENOG4108VXD carboxy-peptidase GYO_2368 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GYO_2370 ENOG4106Z5R GYO_2371 ENOG410841Q phosphoesterase PA-phosphatase related protein GYO_2377 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GYO_2378 ENOG4108TSC N-acetyltransferase GYO_2379 ENOG4107S4Y M20 DapE family protein YgeY GYO_2382 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GYO_2389 ENOG4107T32 3-phytase (EC 3.1.3.8) GYO_2390 ENOG4105C5E polysaccharide biosynthesis protein GYO_2391 ENOG4105E0X reductase GYO_2392 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GYO_2396 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) GYO_2397 ENOG41090WU lipolytic protein G-D-S-L family GYO_2398 ENOG4108KF3 Electron transport protein SCO1 SenC GYO_2400 ENOG4105C7B Threonine dehydratase GYO_2402 ENOG4108UT2 hemolysin iii GYO_2404 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GYO_2408 ENOG4107YX5 Pfam:DUF548 GYO_2409 ENOG4108Y6J UPF0403 protein GYO_2410 ENOG4105C01 Dihydroxy-acid dehydratase GYO_2413 ENOG4108V06 Glutathione peroxidase GYO_2414 ENOG4105CVG Homoserine O-transsuccinylase GYO_2423 ENOG41081VK Ribonuclease GYO_2428 ENOG410890F Dynamin family GYO_2430 ENOG41065KQ synthase GYO_2431 ENOG4105C2W permease GYO_2432 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GYO_2433 ENOG4105CTD carboxy-peptidase GYO_2434 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GYO_2435 ENOG4108UHU Aldolase GYO_2436 ENOG4105D7K pfkb domain protein GYO_2437 ENOG4108M60 Transcriptional regulator GYO_2440 ENOG4105CHR reductase GYO_2441 ENOG4105DVT helicase GYO_2443 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GYO_2445 ENOG4108UKS UPF0398 protein GYO_2447 ENOG4107X2U Inherit from COG: Exonuclease-like protein GYO_2448 ENOG4108I5C dEAD DEAH box helicase GYO_2458 ENOG4105BZ4 penicillin-binding protein GYO_2460 ENOG4105CSM endonuclease III GYO_2462 ENOG4105C5S asparaginyl-tRNA synthetase GYO_2463 ENOG4105CHM Aminotransferase GYO_2465 ENOG4105YAC GYO_2466 ENOG4105DVT helicase GYO_2467 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GYO_2468 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GYO_2469 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GYO_2472 ENOG4105DJ0 Poly(A) Polymerase GYO_2473 ENOG4105CPK Glycosyl transferase (Group 1 GYO_2474 ENOG4105FJR Lmbe family GYO_2475 ENOG4108Z5K methylglyoxal synthase GYO_2476 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GYO_2477 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GYO_2478 ENOG4108JYZ YitT family GYO_2482 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GYO_2486 ENOG41068YB TPR repeat-containing protein GYO_2487 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GYO_2489 ENOG4105CIH Imidazole acetol-phosphate transaminase GYO_2491 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GYO_2492 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GYO_2494 ENOG4108I0Q anthranilate phosphoribosyltransferase GYO_2495 ENOG4105CRQ synthase (Component I) GYO_2496 ENOG4105KHN chorismate mutase GYO_2497 ENOG4105D49 3-dehydroquinate synthase GYO_2498 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GYO_2499 ENOG4105BZU Histidine kinase GYO_2501 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GYO_2502 ENOG4105EAH synthase GYO_2503 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GYO_2504 ENOG4105XXQ heptaprenyl diphosphate synthase component I GYO_2506 ENOG4105EUJ GTP cyclohydrolase i GYO_2507 ENOG4105K70 DNA-binding protein GYO_2512 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GYO_2513 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GYO_2514 ENOG41065D1 GYO_2515 ENOG4105S2F GYO_2518 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GYO_2519 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GYO_2520 ENOG4105CAT Cytidine monophosphate kinase GYO_2523 ENOG4105MSI germination protein ypeb GYO_2526 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) GYO_2527 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GYO_2530 ENOG4107RGJ metallophosphoesterase GYO_2533 ENOG4105I7S Abortive infection protein GYO_2534 ENOG4105C9U ATP-dependent DNA helicase RecQ GYO_2535 ENOG4105T7X GYO_2537 ENOG4108SAX Membrane GYO_2539 ENOG4108JQ1 Dehydrogenase GYO_2540 ENOG4105FF2 Type I DHQase GYO_2543 ENOG4105BZU Histidine kinase GYO_2544 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYO_2545 ENOG4105CRE cytochrome C GYO_2546 ENOG4107TWT Cytochrome c biogenesis protein GYO_2549 ENOG4105FE9 pseudouridine synthase GYO_2551 ENOG4108JIC nucleoside recognition domain protein GYO_2552 ENOG4105DZ1 carboxypeptidase GYO_2554 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GYO_2555 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GYO_2558 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GYO_2559 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GYO_2560 ENOG4108R6K riboflavin synthase, subunit alpha GYO_2561 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GYO_2564 ENOG4105C3F Signal peptidase i GYO_2567 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) GYO_2569 ENOG4107ZE5 PPIases accelerate the folding of proteins GYO_2570 ENOG4105PTM secreted protein GYO_2571 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GYO_2575 ENOG4105CZ3 stage V sporulation protein ad GYO_2576 ENOG41090VF Stage v sporulation protein ac GYO_2579 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYO_2580 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GYO_2581 ENOG41082AN stage II sporulation protein GYO_2584 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) GYO_2585 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GYO_2586 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GYO_2588 ENOG4105I3K Ferric uptake regulator, Fur family GYO_2589 ENOG4105MZ9 stage II sporulation protein m GYO_2592 ENOG4105DFD Na H antiporter GYO_2593 ENOG4108IJ0 Aspartate ammonia-lyase GYO_2594 ENOG4105HDK L-asparaginase GYO_2595 ENOG4108IMY Transcriptional regulator GYO_2597 ENOG4108YZ4 nudix hydrolase GYO_2599 ENOG4105CPC Aldo Keto reductase GYO_2602 ENOG4105CNI cell division protein FtsW GYO_2603 ENOG4105CNI cell division protein FtsW GYO_2606 ENOG4106HZJ GYO_2607 ENOG4105RHY Pfam:UPF0157 GYO_2608 ENOG4105KAC Antibiotic biosynthesis monooxygenase GYO_2609 ENOG4108XET gCN5-related N-acetyltransferase GYO_2611 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GYO_2616 ENOG4105E5W Transporter GYO_2618 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase GYO_2621 ENOG4108IXY short-chain dehydrogenase reductase GYO_2622 ENOG41069FQ Metallo-beta-lactamase superfamily GYO_2623 ENOG4105II7 pyrroline-5-carboxylate reductase GYO_2625 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYO_2627 ENOG410861F 50S ribosomal protein L33 GYO_2628 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GYO_2630 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GYO_2631 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GYO_2632 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GYO_2634 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) GYO_2635 ENOG4108NA0 Uncharacterized conserved protein (COG2071) GYO_2636 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GYO_2637 ENOG4108HNZ carboxyl transferase GYO_2638 ENOG4108ZVT methylmalonyl-coA epimerase GYO_2639 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GYO_2640 ENOG4108QEG Membrane GYO_2641 ENOG4105CDA abc transporter atp-binding protein GYO_2642 ENOG4105E5Q amino acid AbC transporter GYO_2643 ENOG4108HW3 (ABC) transporter GYO_2644 ENOG4108Y6J UPF0403 protein GYO_2645 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GYO_2648 ENOG4105C7S Dehydrogenase GYO_2649 ENOG4105CPP Dehydrogenase, E1 component GYO_2652 ENOG4105CKM Branched-chain carboxylic acid kinase GYO_2653 ENOG4107RDP Dehydrogenase GYO_2655 ENOG4108JUB Transcriptional regulator GYO_2656 ENOG4106CCJ Protein of unknown function (DUF2627) GYO_2657 ENOG4105CR4 methylisocitrate lyase GYO_2658 ENOG4105DXD 2-methylcitrate dehydratase GYO_2660 ENOG4105C1G acyl-Coa dehydrogenase GYO_2661 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GYO_2664 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GYO_2665 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GYO_2668 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYO_2673 ENOG4105DZR Type I site-specific deoxyribonuclease GYO_2678 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GYO_2679 ENOG4107QQR Sporulation GYO_2681 ENOG4105S1Z Stage IV sporulation protein B GYO_2682 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GYO_2684 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GYO_2685 ENOG4105DX0 Hemolysin A GYO_2688 ENOG4105CTB Polyprenyl synthetase GYO_2689 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GYO_2690 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GYO_2691 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GYO_2692 ENOG4105M7K Involved in the transcription termination process (By similarity) GYO_2693 ENOG4108ZSR alkaline shock protein GYO_2694 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GYO_2698 ENOG410644B Stage III sporulation protein af GYO_2700 ENOG4105KQ4 Stage iii sporulation protein ad GYO_2701 ENOG4108CQH stage III sporulation protein AC GYO_2702 ENOG4105KR5 Stage iii sporulation protein GYO_2703 ENOG4105CD2 stage iii sporulation protein aa GYO_2705 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GYO_2706 ENOG4105DC7 peptidase M24 GYO_2707 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GYO_2709 ENOG4105CBJ Metal-dependent enzyme GYO_2712 ENOG4105KST dependent repressor GYO_2713 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GYO_2714 ENOG4105WZW rhodanese family GYO_2715 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GYO_2716 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GYO_2717 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GYO_2718 ENOG4105C0D helicase GYO_2721 ENOG4108IMY Transcriptional regulator GYO_2723 ENOG4105VFR signal peptidase GYO_2736 ENOG41080XP Cbs domain GYO_2738 ENOG4105C37 (CBS) domain GYO_2743 ENOG4105C5X domain protein GYO_2748 ENOG4105E0M Sulfatase GYO_2752 ENOG4107ZXI Rhomboid family GYO_2755 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GYO_2759 ENOG41068DG YceG-like family GYO_2760 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GYO_2761 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GYO_2762 ENOG4105E2Z phosphate ABC transporter (Permease GYO_2763 ENOG4105C8U phosphate abc transporter GYO_2764 ENOG4105CVA phosphate GYO_2765 ENOG4107RF6 penicillin-binding protein GYO_2767 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GYO_2768 ENOG4105SXS Protein of unknown function (DUF456) GYO_2771 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GYO_2772 ENOG41063Y9 GYO_2773 ENOG4108U5J '-nucleotidase GYO_2774 ENOG4105N80 Ferric uptake regulator, Fur family GYO_2775 ENOG4108JYZ YitT family GYO_2776 ENOG41069ZM Protein of unknown function (DUF2624) GYO_2777 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GYO_2780 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GYO_2781 ENOG4105EGD dinuclear metal center protein, YbgI family GYO_2785 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYO_2786 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GYO_2787 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 GYO_2788 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GYO_2790 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GYO_2791 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GYO_2792 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GYO_2794 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GYO_2795 ENOG4105KG3 cytidine deaminase GYO_2797 ENOG4107YR5 Diacylglycerol kinase GYO_2798 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GYO_2799 ENOG4105CTJ Metal Dependent Phosphohydrolase GYO_2801 ENOG4105C9A Phoh family GYO_2804 ENOG41068P3 sporulation protein YqfC GYO_2806 ENOG4105DI5 UPF0365 protein GYO_2807 ENOG4105F7J membrane-bound serine protease GYO_2808 ENOG4105KTH gatB Yqey GYO_2811 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GYO_2812 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GYO_2813 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GYO_2815 ENOG4105CFG Acts as a chaperone (By similarity) GYO_2816 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GYO_2817 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GYO_2818 ENOG4105CSA Coproporphyrinogen iii oxidase GYO_2819 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GYO_2821 ENOG4108ZRV stage ii sporulation protein p GYO_2822 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) GYO_2823 ENOG41082YS Binds directly to 16S ribosomal RNA GYO_2824 ENOG4105TQK DNA polymerase iii, delta' subunit GYO_2827 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GYO_2828 ENOG4108UK2 deaminase GYO_2829 ENOG4105KQC Competence protein GYO_2831 ENOG4108D32 Methyltransferase GYO_2833 ENOG4108WF2 Metal Dependent Phosphohydrolase GYO_2834 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GYO_2835 ENOG410812S Rna-binding protein GYO_2836 ENOG4105E2X shikimate dehydrogenase GYO_2837 ENOG4105CQW ribosome biogenesis GTPase YqeH GYO_2838 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GYO_2841 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GYO_2842 ENOG41080BT SNARE associated Golgi GYO_2845 ENOG4105WFK nuclease GYO_2846 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYO_2848 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GYO_2850 ENOG4105KME endoribonuclease L-psp GYO_2851 ENOG4105HDK L-asparaginase GYO_2852 ENOG4105C7B Threonine dehydratase GYO_2866 ENOG41087NI Sulfite exporter TauE/SafE GYO_2867 ENOG4105VFE sira family GYO_2868 ENOG4107TPS domain protein GYO_2870 ENOG4105VFE sira family GYO_2871 ENOG4105C72 UPF0176 protein GYO_2872 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GYO_2877 ENOG4105WH1 Two component transcriptional regulator luxr family GYO_2878 ENOG4105BZU Histidine kinase GYO_2879 ENOG41087NI Sulfite exporter TauE/SafE GYO_2881 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GYO_2884 ENOG4105CID antiterminator GYO_2885 ENOG4105CS2 ec 3.2.1.21 GYO_2886 ENOG4105C5Y PTS System GYO_2887 ENOG4105C59 p-type ATPase GYO_2888 ENOG410681U heavy metal transport detoxification protein GYO_2889 ENOG4105VPX protein, conserved in bacteria GYO_2896 ENOG4105KVH Transcriptional regulator GYO_2898 ENOG4108DBC nitroreductase GYO_2900 ENOG41067XF inhibitor GYO_2903 ENOG41090E6 transcriptional regulator MERR family GYO_2906 ENOG4105C37 (CBS) domain GYO_2909 ENOG4105X7F GYO_2915 ENOG4105UNS Pfam:DUF419 GYO_2918 ENOG4108MEK Metal-binding protein YodA GYO_2919 ENOG410904A RNA polymerase GYO_2920 ENOG4105CPC Aldo Keto reductase GYO_2921 ENOG41083Q9 chitosanase GYO_2922 ENOG4105X5K response regulator receiver protein GYO_2923 ENOG4108VQT Alpha beta hydrolase fold protein GYO_2924 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein GYO_2925 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein GYO_2927 ENOG4105PGS Spore coat protein GYO_2928 ENOG4105E2A Dehydrogenase GYO_2931 ENOG4105CF7 AraC family transcriptional regulator GYO_2933 ENOG4105VUF Transcriptional regulator GYO_2934 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GYO_2935 ENOG4105DQ4 alcohol dehydrogenase GYO_2936 ENOG4108Z0Z intracellular protease Pfpi family GYO_2937 ENOG4108HKT sucrose-6-phosphate hydrolase GYO_2938 ENOG4105F3R pts system mannose fructose sorbose family iid GYO_2939 ENOG4105ETZ PTS System GYO_2940 ENOG4108IQ3 PTS system GYO_2941 ENOG4105YHU PTS system GYO_2942 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GYO_2946 ENOG4105C85 amino acid GYO_2947 ENOG4105N14 lysine exporter protein LysE YggA GYO_2948 ENOG4108NGU Transcriptional regulator GYO_2949 ENOG4105JVQ RNA Polymerase GYO_2950 ENOG4108P49 AntiSigma factor GYO_2951 ENOG4105EXC Acyl-transferase GYO_2952 ENOG4105WDR GYO_2953 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GYO_2954 ENOG41082JN Transcriptional regulator GYO_2959 ENOG4105TMB Formate nitrite transporter GYO_2961 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) GYO_2962 ENOG4108JB9 formate dehydrogenase GYO_2965 ENOG4105C28 cystathionine GYO_2968 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GYO_2971 ENOG4107XRG penicillin-binding protein GYO_2972 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GYO_2973 ENOG4105DBI uridine monophosphokinase GYO_2974 ENOG4105CFP Peptidase U32 GYO_2975 ENOG4105XYU peptidase (U32 family) GYO_2976 ENOG4108VQJ O-methyltransferase GYO_2977 ENOG4105HHA aminodeoxychorismate lyase GYO_2979 ENOG4105VPH UPF0473 protein GYO_2980 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GYO_2981 ENOG4105VBH UPF0297 protein GYO_2982 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GYO_2983 ENOG4105C02 permease GYO_2985 ENOG41060CR GYO_2987 ENOG4105C7H Helicase, RecD TraA family GYO_2989 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GYO_2990 ENOG4105C3J Cysteine desulfurase GYO_2992 ENOG4105D1H recombination factor protein RarA GYO_2993 ENOG4105CUZ uba thif-type nad fad binding protein GYO_2995 ENOG4105C9M aspartyl-trna synthetase GYO_2996 ENOG4105CUT histidyl-tRNA synthetase GYO_2998 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GYO_3000 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GYO_3001 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GYO_3002 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GYO_3003 ENOG41067VP Protein of unknown function (DUF1049) GYO_3004 ENOG4105NCW Trka-c domain protein GYO_3005 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GYO_3007 ENOG4105CKP Polysaccharide Biosynthesis Protein GYO_3008 ENOG4108QG2 Membrane GYO_3009 ENOG4105NAP GYO_3010 ENOG4105VIE preprotein translocase, subunit YajC GYO_3011 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GYO_3012 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GYO_3013 ENOG41061AI Protein of unknown function (DUF2905) GYO_3014 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GYO_3015 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GYO_3017 ENOG4105IE8 Alpha-ketoglutarate permease GYO_3018 ENOG4105CK5 oxidoreductase GYO_3021 ENOG4105BZG amino acid carrier protein GYO_3022 ENOG4105CDY transcriptional regulatory protein GYO_3024 ENOG4106678 morphogenetic protein associated with SpoVID GYO_3025 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GYO_3026 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GYO_3027 ENOG4108IYU L-aspartate oxidase GYO_3030 ENOG4105CQC Prephenate dehydratase GYO_3031 ENOG41090I5 UPF0735 ACT domain-containing protein GYO_3032 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GYO_3035 ENOG4105K46 50S ribosomal protein l27 GYO_3036 ENOG4105X36 (ribosomal) protein GYO_3037 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GYO_3041 ENOG4107QMS site-determining protein GYO_3042 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GYO_3043 ENOG4105YHC Rod shape-determining protein MreD GYO_3044 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GYO_3045 ENOG4105DFF Rod shape-determining protein mreb GYO_3046 ENOG4105W5Q DNA repair protein (RadC GYO_3047 ENOG4108Z03 MAF-like protein GYO_3049 ENOG4106A3R peptidase GYO_3051 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GYO_3052 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GYO_3054 ENOG4106AR7 Spore coat protein GYO_3055 ENOG41068KH stage VI sporulation protein D GYO_3056 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GYO_3057 ENOG4105D52 delta-aminolevulinic acid dehydratase GYO_3059 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GYO_3061 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GYO_3063 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GYO_3064 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GYO_3065 ENOG4108IUQ atp-dependent protease GYO_3066 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GYO_3067 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GYO_3070 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GYO_3071 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GYO_3072 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GYO_3073 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GYO_3074 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GYO_3075 ENOG4108ZP8 Acetolactate synthase small subunit GYO_3076 ENOG4105C7K acetolactate synthase GYO_3078 ENOG4105I4A GCN5-related N-acetyltransferase GYO_3079 ENOG4107KM7 Heat induced stress protein YflT GYO_3081 ENOG4105M59 Phosphodiesterase, mj0936 family GYO_3082 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GYO_3083 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GYO_3084 ENOG4108XJQ germination protein GYO_3085 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GYO_3086 ENOG41067TZ transcriptional regulator, MarR family GYO_3087 ENOG4105PFC Transcriptional regulator GYO_3089 ENOG4105E33 succinate dehydrogenase GYO_3091 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GYO_3093 ENOG4105CFH Aspartokinase GYO_3096 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GYO_3097 ENOG4105K63 Thioredoxin GYO_3098 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) GYO_3099 ENOG4105C10 Electron transfer flavoprotein GYO_3100 ENOG4105BZJ Electron transfer flavoprotein GYO_3101 ENOG41060WC Enoyl-CoA hydratase GYO_3102 ENOG4107Z3H Transcriptional regulator, TetR family GYO_3103 ENOG4105CEY Amp-dependent synthetase and ligase GYO_3105 ENOG4105C98 muts2 protein GYO_3106 ENOG4105DCG PHP domain protein GYO_3109 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GYO_3110 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GYO_3111 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GYO_3112 ENOG4108RWN rrna methyltransferase GYO_3113 ENOG41067MF small acid-soluble spore protein GYO_3115 ENOG4105CQB FAD linked oxidase domain protein GYO_3116 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GYO_3121 ENOG4105K7K Transcriptional regulator GYO_3122 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) GYO_3123 ENOG4105DRS transport system, permease GYO_3126 ENOG4108MDK Dehydrogenase GYO_3128 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GYO_3129 ENOG4105EF1 ribulokinase GYO_3132 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase GYO_3133 ENOG4105CN9 Peptidase m42 family protein GYO_3135 ENOG410696E Membrane GYO_3136 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GYO_3137 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GYO_3140 ENOG41067MG lrgb family GYO_3142 ENOG4105DY9 regulatoR GYO_3143 ENOG4108HRK Histidine kinase GYO_3144 ENOG4105U0R haloacid dehalogenase-like hydrolase GYO_3145 ENOG4105C22 threonyL-tRNA synthetase GYO_3150 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GYO_3151 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GYO_3152 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GYO_3153 ENOG4105KVH Transcriptional regulator GYO_3154 ENOG4105F27 Major Facilitator GYO_3155 ENOG4105CV8 reductase GYO_3156 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GYO_3158 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GYO_3159 ENOG4105C2M dna polymerase I GYO_3161 ENOG4105BZU Histidine kinase GYO_3162 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GYO_3164 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GYO_3165 ENOG4108HMX isocitrate dehydrogenase (NADP) GYO_3166 ENOG4105BZN citrate synthase GYO_3168 ENOG4108REF Sporulation integral membrane protein ytvi GYO_3170 ENOG4105FS0 cytoplasmic membrane protein GYO_3171 ENOG4105CA9 Pyruvate kinase GYO_3172 ENOG4105CTQ phosphohexokinase GYO_3174 ENOG4108IEY Carboxyl transferase domain GYO_3175 ENOG4105C6K Malic enzyme GYO_3176 ENOG4105C0B DNA polymerase III (alpha subunit) GYO_3177 ENOG4105VV2 GYO_3179 ENOG4106EVM GYO_3180 ENOG4105SFS phosphoesterase RecJ domain protein GYO_3184 ENOG4105E8R UPF0173 metal-dependent hydrolase GYO_3188 ENOG4105CH7 arginosuccinase GYO_3189 ENOG4105CDH Citrulline--aspartate ligase GYO_3190 ENOG4105EPU Molybdenum cofactor synthesis domain protein GYO_3191 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GYO_3194 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GYO_3195 ENOG4105KBJ sporulation protein ytfj GYO_3197 ENOG4105VK3 rdd domain containing protein GYO_3198 ENOG4105D07 Signal peptide peptidase, SppA GYO_3200 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GYO_3201 ENOG4105EFZ amidohydrolase GYO_3202 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GYO_3209 ENOG4105U5Y Transcriptional regulator GYO_3211 ENOG4105BZU Histidine kinase GYO_3213 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GYO_3215 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GYO_3217 ENOG4105F1V Acetoin utilization protein GYO_3218 ENOG4105W87 Cbs domain GYO_3219 ENOG4105DGU Histone deacetylase GYO_3220 ENOG4105ER2 Ompa motb domain protein GYO_3221 ENOG4107R0U MotA TolQ exbB proton channel GYO_3222 ENOG4105ETE Transcriptional regulator (LacI family GYO_3223 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GYO_3227 ENOG4105DFU Cell wall formation (By similarity) GYO_3229 ENOG4108VDD TRNA binding domain protein GYO_3233 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ GYO_3236 ENOG4105C6K Malic enzyme GYO_3237 ENOG4105C8F Beta-lactamase domain protein GYO_3238 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GYO_3240 ENOG4108V15 phosphotransferase enzyme family GYO_3241 ENOG4108IUM Glycogen debranching enzyme GYO_3244 ENOG4107F58 2'-5' rna ligase GYO_3245 ENOG4105C6T cysteine synthase GYO_3246 ENOG4107QSE Dipeptidase GYO_3250 ENOG4105YW5 deoR family transcriptional regulator GYO_3253 ENOG4105CBX hi0933 family GYO_3255 ENOG4105C94 Transporter GYO_3257 ENOG4105MU9 integral membrane protein GYO_3258 ENOG4105DDC Oxidoreductase domain protein GYO_3260 ENOG4105F5H Glycosyl Hydrolase Family 88 GYO_3262 ENOG41075H3 AraC family transcriptional regulator GYO_3264 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GYO_3267 ENOG4106A3M Cytochrome p-450 GYO_3268 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GYO_3270 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GYO_3271 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GYO_3274 ENOG4105NTD Inherit from COG: Hydrolase GYO_3277 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GYO_3278 ENOG4105I1K ABC transporter GYO_3281 ENOG4105DQ6 Transposase GYO_3282 ENOG41085GJ domain protein GYO_3283 ENOG4105C8T Leucyl-tRNA synthetase GYO_3285 ENOG4105BZU Histidine kinase GYO_3286 ENOG410605W Major Facilitator GYO_3287 ENOG4106UBQ GYO_3289 ENOG4105C19 ABC transporter GYO_3290 ENOG4105EWM Histidine kinase GYO_3292 ENOG4107R34 abc transporter permease protein GYO_3293 ENOG4105C19 ABC transporter GYO_3296 ENOG4105DVE abc transporter atp-binding protein GYO_3297 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GYO_3300 ENOG4105N5T Radical SAM Protein GYO_3303 ENOG4105E8V Alpha Beta Hydrolase Fold protein GYO_3304 ENOG4108Z0R Transferase GYO_3305 ENOG4105C85 amino acid GYO_3306 ENOG4105CAQ asparagine synthetase GYO_3307 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GYO_3308 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GYO_3311 ENOG4105D2X ABC transporter substrate-binding protein GYO_3313 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GYO_3317 ENOG4108RMU ferritin dps family protein GYO_3320 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GYO_3321 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GYO_3322 ENOG4108V2W Carbonate dehydratase GYO_3328 ENOG4105CC5 ABC transporter GYO_3329 ENOG4105CC5 ABC transporter GYO_3330 ENOG4105DIK (ABC) transporter GYO_3331 ENOG4105DSE periplasmic solute binding protein GYO_3332 ENOG4105DTQ mandelate racemase muconate lactonizing GYO_3333 ENOG4105CEY Amp-dependent synthetase and ligase GYO_3334 ENOG4108IPT Naphthoate synthase GYO_3335 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GYO_3336 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GYO_3337 ENOG4105E4F Isochorismate synthase GYO_3342 ENOG4108IAJ Nad-dependent epimerase dehydratase GYO_3343 ENOG4107SBE Glycosyl transferase (Group 1 GYO_3346 ENOG4107SBE Glycosyl transferase (Group 1 GYO_3347 ENOG4108KS4 Spore coat protein GYO_3350 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GYO_3352 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GYO_3377 ENOG4105N67 Proton-coupled thiamine transporter YuaJ GYO_3378 ENOG4105VRR gCN5-related N-acetyltransferase GYO_3379 ENOG4105DZ6 Band 7 protein GYO_3381 ENOG4106DF1 GYO_3382 ENOG4108VNY MOSC domain protein GYO_3383 ENOG4108JB8 alcohol dehydrogenase GYO_3384 ENOG4105C26 Dehydrogenase GYO_3385 ENOG4105TRT Transcriptional regulator GYO_3388 ENOG4105CZN Potassium uptake protein GYO_3389 ENOG4107I77 yiaA/B two helix domain GYO_3390 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GYO_3398 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GYO_3400 ENOG4105EE0 oxidoreductase GYO_3401 ENOG4105DKG l-rhamnose isomerase GYO_3402 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) GYO_3403 ENOG4105DET Rhamnulokinase GYO_3404 ENOG4105E98 transcriptional regulator DeoR family GYO_3406 ENOG4105C8Q Methyl-accepting chemotaxis GYO_3407 ENOG4105C8Q Methyl-accepting chemotaxis GYO_3408 ENOG4105C8Q Methyl-accepting chemotaxis GYO_3409 ENOG4105C8Q Methyl-accepting chemotaxis GYO_3413 ENOG4105EA8 2-Nitropropane dioxygenase GYO_3414 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GYO_3416 ENOG4105C37 (CBS) domain GYO_3419 ENOG4107PBV potassium channel GYO_3420 ENOG4107PBV potassium channel GYO_3423 ENOG4107QYV phosphohexose isomerase GYO_3425 ENOG4107QW4 alcohol dehydrogenase GYO_3426 ENOG4105WG9 Conserved Protein GYO_3428 ENOG4105CHM Aminotransferase GYO_3429 ENOG4108ZB6 transcriptional regulator AsnC family GYO_3430 ENOG4108MUZ hydrolase GYO_3432 ENOG4105C87 Aminotransferase class I and II GYO_3433 ENOG4108HGU Histidine kinase GYO_3434 ENOG4105Y38 Kinase-associated protein B GYO_3438 ENOG4105BZ4 penicillin-binding protein GYO_3439 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GYO_3442 ENOG4108MRH transcriptional regulatory protein GYO_3443 ENOG4105DIH basic membrane GYO_3444 ENOG4108JQ9 ABC transporter GYO_3445 ENOG4105UIB (ABC) transporter GYO_3450 ENOG4105D65 subunit l GYO_3451 ENOG4105HC0 Na H antiporter GYO_3452 ENOG4108ZE9 Monovalent cation H antiporter subunit C GYO_3453 ENOG4108JPZ Monovalent cation H antiporter subunit D GYO_3454 ENOG4105SC1 monovalent cation H antiporter subunit E GYO_3456 ENOG4105KJM monovalent cation h antiporter subunit g GYO_3457 ENOG4105KA0 thioesterase Superfamily protein GYO_3459 ENOG4105BZU Histidine kinase GYO_3465 ENOG4105D58 Diguanylate phosphodiesterase GYO_3466 ENOG4105DAP Nicotinate phosphoribosyltransferase GYO_3471 ENOG4105C02 permease GYO_3475 ENOG410904N short-chain dehydrogenase reductase GYO_3482 ENOG4108K8K Transcriptional regulator GYO_3483 ENOG4105DCF alanine dehydrogenase GYO_3486 ENOG4105WQT MbtH domain protein GYO_3487 ENOG4105CEY Amp-dependent synthetase and ligase GYO_3488 ENOG4105WQI isochorismatase GYO_3489 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GYO_3490 ENOG4105E4F Isochorismate synthase GYO_3491 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GYO_3493 ENOG4105NIV Esterase GYO_3497 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GYO_3499 ENOG41069ER domain protein GYO_3502 ENOG4105CEP NADH dehydrogenase GYO_3503 ENOG4105CAY ferredoxin--nadp reductase GYO_3507 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GYO_3509 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GYO_3512 ENOG4105ZKE UPF0349 protein GYO_3515 ENOG41083MR nifu domain-containing protein GYO_3516 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GYO_3517 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GYO_3518 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GYO_3519 ENOG4105D6E homoserine dehydrogenase GYO_3521 ENOG4108W5N phosphatidylglycerophosphatase a GYO_3522 ENOG4105D4U had-superfamily hydrolase, subfamily iia GYO_3524 ENOG4105MMD transcriptional regulator GYO_3525 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GYO_3526 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GYO_3527 ENOG4105FAA peptidase M23 GYO_3528 ENOG4108YTE sporulation protein YunB GYO_3529 ENOG4105KZD Domain of unknown function (DUF1805) GYO_3530 ENOG4107R8B 5'-nucleotidase GYO_3532 ENOG4105I3N Conserved Protein GYO_3534 ENOG4105CD3 dihydroorotase GYO_3535 ENOG4105G9B Transcriptional regulator GYO_3538 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) GYO_3539 ENOG4105VT2 5-hydroxyisourate hydrolase GYO_3544 ENOG4107QIV Cytochrome c biogenesis protein GYO_3545 ENOG4107YV9 domain protein GYO_3546 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GYO_3549 ENOG4105XRQ Xanthine dehydrogenase accessory factor GYO_3550 ENOG4105C5R Aminotransferase GYO_3552 ENOG4107QYG anthranilate phosphoribosyltransferase GYO_3554 ENOG4108K8S endonuclease I GYO_3555 ENOG4108IJ9 (ABC) transporter GYO_3556 ENOG4105FDP GntR family transcriptional regulator GYO_3557 ENOG4108KPW sugar kinase GYO_3558 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GYO_3559 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYO_3560 ENOG4105XN3 extracellular solute-binding protein family 1 GYO_3561 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine GYO_3562 ENOG4105PKS Excinuclease abc c subunit domain protein GYO_3563 ENOG4107VFR oxidoreductase GYO_3566 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GYO_3567 ENOG4105DIW FeS assembly protein SUFB GYO_3568 ENOG4108UNV SUF system FeS assembly protein, NifU family GYO_3569 ENOG4105C9B Cysteine desulfurase GYO_3570 ENOG4105JRK feS assembly protein SufD GYO_3571 ENOG4105C3K feS assembly ATPase SufC GYO_3574 ENOG4105D01 (LipO)protein GYO_3575 ENOG4108UMI ABC transporter, permease GYO_3576 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GYO_3582 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GYO_3583 ENOG41080E8 Transcriptional regulator, Spx MgsR family GYO_3584 ENOG4105C1G acyl-Coa dehydrogenase GYO_3585 ENOG4105CHU acetyl-coa acetyltransferase GYO_3591 ENOG41067TZ transcriptional regulator, MarR family GYO_3592 ENOG4105C0R drug resistance transporter emrb qaca subfamily GYO_3593 ENOG4105MDS 4-oxalocrotonate tautomerase GYO_3595 ENOG4105EGI Transcriptional regulator GYO_3597 ENOG4105E0A ABC, transporter GYO_3601 ENOG4105E1F short-chain dehydrogenase reductase GYO_3602 ENOG4105HUF DNA protection during starvation protein GYO_3603 ENOG4105C0H protease GYO_3606 ENOG4105F3H Histidine kinase GYO_3608 ENOG41067SE Tetr family transcriptional regulator GYO_3609 ENOG4105C9Q fumarate hydratase class II GYO_3614 ENOG4105WH1 Two component transcriptional regulator luxr family GYO_3615 ENOG4105ENE Histidine kinase GYO_3618 ENOG41087YS Phage shock protein A GYO_3622 ENOG4108WBT adenosyltransferase GYO_3623 ENOG4105E0A ABC, transporter GYO_3624 ENOG4105EHG Permease protein GYO_3625 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GYO_3626 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GYO_3627 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GYO_3629 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GYO_3631 ENOG4106DF4 Sigma-70, region 4 GYO_3633 ENOG4105F0F Oxalate decarboxylase GYO_3635 ENOG4107RBB ABC transporter, permease GYO_3636 ENOG4105C19 ABC transporter GYO_3637 ENOG4108WMK Efflux transporter RND family MFP subunit GYO_3638 ENOG4105E0A ABC, transporter GYO_3639 ENOG4105EHG Permease protein GYO_3640 ENOG4105DQ5 transport system permease protein GYO_3644 ENOG4105D5Q Arginine ornithine antiporter GYO_3646 ENOG4107K5X Membrane-bound metal-dependent hydrolase GYO_3647 ENOG4107QZ2 Sulfatase GYO_3648 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GYO_3649 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GYO_3650 ENOG4105E0C molybdate abc transporter GYO_3654 ENOG4105EEQ Na H antiporter GYO_3655 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GYO_3656 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GYO_3657 ENOG4105EEM helicase GYO_3659 ENOG4105EN6 Membrane GYO_3661 ENOG4107ZQN disulfide bond GYO_3662 ENOG4105C59 p-type ATPase GYO_3663 ENOG4105C59 p-type ATPase GYO_3664 ENOG410681U heavy metal transport detoxification protein GYO_3665 ENOG4105VPX protein, conserved in bacteria GYO_3666 ENOG4105D9R oxidoreductase GYO_3667 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GYO_3668 ENOG4105ME7 Membrane GYO_3669 ENOG4105DRR Transcriptional regulator, GntR family GYO_3670 ENOG4108UZ3 Transporter GYO_3672 ENOG4105RXJ GYO_3673 ENOG4105KPY Small multidrug resistance protein GYO_3674 ENOG4105KBX Transcriptional regulator, TetR family GYO_3675 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GYO_3677 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GYO_3678 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GYO_3680 ENOG4105XZU Preprotein translocase, subunit SecG GYO_3685 ENOG4105KVH Transcriptional regulator GYO_3686 ENOG4105C8Q Methyl-accepting chemotaxis GYO_3691 ENOG4105DA5 (ABC) transporter GYO_3697 ENOG4105R40 Glycine betaine carnitine choline GYO_3698 ENOG4108HQR Glycine betaine GYO_3699 ENOG4105E90 ABC transporter GYO_3700 ENOG4108IJ8 ABC transporter GYO_3702 ENOG4107HG4 Transcriptional regulator GYO_3703 ENOG4105R40 Glycine betaine carnitine choline GYO_3704 ENOG4108HQR Glycine betaine GYO_3705 ENOG4105E90 ABC transporter GYO_3706 ENOG4108IJ8 ABC transporter GYO_3707 ENOG4107HG4 Transcriptional regulator GYO_3708 ENOG4108QCI YvbH-like oligomerisation region GYO_3710 ENOG4105T65 Membrane-associated protein GYO_3712 ENOG4108W0I acetyltransferase GYO_3713 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GYO_3714 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GYO_3715 ENOG4105CP7 Triose-phosphate isomerase GYO_3716 ENOG4105BZA Phosphoglycerate kinase GYO_3718 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GYO_3722 ENOG4105CMD Transcriptional regulator, GntR family GYO_3723 ENOG4105DEN Luciferase family GYO_3725 ENOG4105GZI Transcriptional regulator GYO_3726 ENOG4107RT3 EamA-like transporter family GYO_3728 ENOG4105VRS hydrolase family 18 GYO_3729 ENOG4105DQ6 Transposase GYO_3731 ENOG4105VRS hydrolase family 18 GYO_3732 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) GYO_3733 ENOG4107QR9 Iron-sulfur cluster binding protein GYO_3734 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GYO_3739 ENOG4105BZU Histidine kinase GYO_3740 ENOG4105KCT ABC transporter GYO_3741 ENOG4108M15 ABC transporter GYO_3742 ENOG4107R6F Alpha Beta Hydrolase Fold protein GYO_3743 ENOG4108MJI response regulator GYO_3746 ENOG4105EG2 ABC transporter, permease GYO_3748 ENOG4107FKK extracellular solute-binding protein family 1 GYO_3753 ENOG4105DAA L-lactate GYO_3754 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYO_3757 ENOG4108ZPC Polysaccharide pyruvyl transferase GYO_3758 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GYO_3759 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family GYO_3760 ENOG4105D3Q Sugar transferase GYO_3762 ENOG4105K64 Glycosyl transferase, family 2 GYO_3764 ENOG4107QRS glycosyltransferase group 2 family protein GYO_3765 ENOG41068W6 Capsular polysaccharide biosynthesis protein GYO_3766 ENOG4108KMV Glycosyl transferase (Group 1 GYO_3767 ENOG4105K64 Glycosyl transferase, family 2 GYO_3768 ENOG4108PQP glycosyl transferase group 1 GYO_3770 ENOG4108QV3 biosynthesis protein GYO_3771 ENOG4105HTX biosynthesis protein GYO_3773 ENOG4105EBR Carboxylesterase GYO_3775 ENOG4105PY6 Phenolic acid decarboxylase GYO_3776 ENOG4105NI3 Protein of unknown function (DUF3237) GYO_3778 ENOG4105FQP Beta-lactamase GYO_3780 ENOG4105EDQ levansucrase EC 2.4.1.10 GYO_3781 ENOG4108HKT sucrose-6-phosphate hydrolase GYO_3782 ENOG4107QTZ amino acid GYO_3788 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GYO_3789 ENOG4107URF beta-phospho-glucomutase GYO_3790 ENOG4105CG3 alpha amylase, catalytic region GYO_3793 ENOG4105EG2 ABC transporter, permease GYO_3794 ENOG4105D56 permease protein GYO_3795 ENOG4107FKK extracellular solute-binding protein family 1 GYO_3796 ENOG4108IUK alpha amylase, catalytic GYO_3797 ENOG4105FKQ transcriptional regulator GYO_3798 ENOG4108URH decarboxylase GYO_3799 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain GYO_3800 ENOG4105CHH sulfate transporter GYO_3801 ENOG4108V2W Carbonate dehydratase GYO_3802 ENOG4105C5I Dehydrogenase GYO_3804 ENOG4105C19 ABC transporter GYO_3805 ENOG4105EWM Histidine kinase GYO_3807 ENOG4107A6P GYO_3808 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GYO_3809 ENOG4105KRI phosphocarrier protein (HPr GYO_3810 ENOG4105CIE May be required for sporulation (By similarity) GYO_3811 ENOG4105CHW UPF0052 protein GYO_3812 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GYO_3813 ENOG4108Z4K mutator MutT protein GYO_3815 ENOG4105C3M thioredoxin reductase GYO_3818 ENOG4105BZ1 (ABC) transporter GYO_3821 ENOG4106FGC GYO_3823 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GYO_3824 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GYO_3825 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GYO_3826 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GYO_3827 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GYO_3828 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GYO_3829 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GYO_3830 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GYO_3832 ENOG4108E16 pectate lyase GYO_3833 ENOG4108S4C acetyltransferase GYO_3834 ENOG4107XGZ Hydrolase GYO_3835 ENOG4105HKU nucleoside recognition domain-containing protein GYO_3836 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GYO_3837 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GYO_3838 ENOG4105CE4 GlcNAc 6-P deacetylase GYO_3839 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GYO_3840 ENOG4105FDP GntR family transcriptional regulator GYO_3841 ENOG41088CQ domain protein GYO_3843 ENOG4106A3M Cytochrome p-450 GYO_3844 ENOG410625E GYO_3848 ENOG41086DT Membrane protein of unknown function GYO_3849 ENOG41067S9 phage shock protein C, PspC GYO_3850 ENOG4108PY7 GYO_3853 ENOG4105I03 Flagellin GYO_3854 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GYO_3855 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GYO_3860 ENOG4105MKU Transcriptional regulator GYO_3864 ENOG4105CN1 protease GYO_3865 ENOG4105CRP Part of the ABC transporter FtsEX involved in GYO_3866 ENOG4105CAK Cell division ATP-binding protein ftsE GYO_3869 ENOG4105DQ6 Transposase GYO_3871 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GYO_3873 ENOG4105MS2 ribosomal subunit Interface protein GYO_3877 ENOG4105MQ3 flagellar protein FliS GYO_3878 ENOG4107RT6 flagellar hook-associated GYO_3879 ENOG41083S7 flagellar protein FlaG GYO_3880 ENOG4105I03 Flagellin GYO_3881 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GYO_3882 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GYO_3883 ENOG4105MKD GYO_3884 ENOG4105DTJ flagellar hook-associated protein GYO_3885 ENOG4105E1Q flagellar hook-associated protein GYO_3888 ENOG4105RU3 GYO_3889 ENOG41081UC Inherit from COG: Competence protein GYO_3893 ENOG4105WH1 Two component transcriptional regulator luxr family GYO_3894 ENOG4105BZU Histidine kinase GYO_3895 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GYO_3896 ENOG4108KGH TRANSCRIPTIONal GYO_3903 ENOG4108RDQ ABC transporter GYO_3905 ENOG4105ESV Glycosyl transferase, family 4 GYO_3906 ENOG4107EF8 Glycosyl transferase (Group 1 GYO_3909 ENOG4105QZI O-Antigen Polymerase GYO_3910 ENOG4105C6Y Udp-glucose 6-dehydrogenase GYO_3911 ENOG4107RA4 Glycosyl transferase (Group 1 GYO_3912 ENOG4105PSV Polysaccharide Biosynthesis Protein GYO_3913 ENOG4105D3Q Sugar transferase GYO_3915 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GYO_3916 ENOG4105JFG SpoIID LytB domain protein GYO_3919 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GYO_3923 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GYO_3924 ENOG4105EY8 ABC transporter GYO_3927 ENOG4107SJB teichoic acid biosynthesis GYO_3929 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase GYO_3938 ENOG4105DG6 mannose-6-phosphate isomerase GYO_3941 ENOG4108NHD germination protein GYO_3942 ENOG4105C54 Major Facilitator superfamily GYO_3943 ENOG4108KGH TRANSCRIPTIONal GYO_3944 ENOG4105J7I hydrolase GYO_3945 ENOG4105K4H Nlp p60 protein GYO_3947 ENOG4105PNM synthesis protein GYO_3949 ENOG4105N98 Capsule biosynthesis protein capB GYO_3950 ENOG4105ETE Transcriptional regulator (LacI family GYO_3951 ENOG4108RVA ribokinase GYO_3952 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GYO_3953 ENOG4105C2J ABC transporter GYO_3954 ENOG4105CNN ABC, transporter GYO_3955 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GYO_3958 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GYO_3959 ENOG4107FQX Alpha-acetolactate decarboxylase GYO_3961 ENOG4107RSM transcriptional regulator GYO_3964 ENOG4107XC4 flavin reductase domain protein, FMN-binding GYO_3966 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GYO_3968 ENOG4105CAH Chromate GYO_3969 ENOG4105FGV Chromate GYO_3971 ENOG4108WS4 fmn reductase GYO_3972 ENOG4107V2S Transcriptional regulator GYO_3974 ENOG410874W AraC family transcriptional regulator GYO_3975 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GYO_3984 ENOG4105C6Y Udp-glucose 6-dehydrogenase GYO_3985 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GYO_3986 ENOG4107YJ4 chain length determinant protein GYO_3987 ENOG4105HTX biosynthesis protein GYO_3989 ENOG4105KBK Zinc finger, swim domain protein GYO_3990 ENOG4105C0D helicase GYO_3992 ENOG410667J hydrolase GYO_3993 ENOG4105E98 transcriptional regulator DeoR family GYO_3994 ENOG4105Z8H single-stranded DNA-binding protein GYO_3997 ENOG4108Z6X (sortase) family GYO_3999 ENOG4108VAC response regulator GYO_4001 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GYO_4002 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GYO_4004 ENOG4105CGA flagellar basal-body rod protein FlgG GYO_4006 ENOG4105DFF Rod shape-determining protein mreb GYO_4007 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GYO_4008 ENOG4107MII Sugar-specific transcriptional regulator TrmB GYO_4009 ENOG4105CZM Major Facilitator GYO_4010 ENOG4108M26 parallel beta-helix repeat protein GYO_4011 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GYO_4012 ENOG41080V3 Major Facilitator superfamily GYO_4013 ENOG4105D3W isochorismatase GYO_4014 ENOG4107P26 GYO_4015 ENOG4105BZU Histidine kinase GYO_4017 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GYO_4019 ENOG4105FRN stage II sporulation protein GYO_4020 ENOG4107TCE N-acetyltransferase GYO_4024 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GYO_4025 ENOG4107TXC Transcriptional regulator GYO_4026 ENOG4106BRK GYO_4027 ENOG4108RYK Nad-dependent epimerase dehydratase GYO_4028 ENOG4108Z40 Transcriptional regulator GYO_4029 ENOG4105CQM Urea amidohydrolase subunit alpha GYO_4030 ENOG4105KI2 Urea amidohydrolase subunit beta GYO_4031 ENOG4108YZ9 Urea amidohydrolase subunit gamma GYO_4032 ENOG4108IV0 ABC, transporter GYO_4033 ENOG4105C0Z ABC transporter GYO_4035 ENOG4105C32 Amino acid ABC transporter (Permease) GYO_4036 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein GYO_4042 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GYO_4044 ENOG4108TF4 von Willebrand factor, type A GYO_4047 ENOG4105JFG SpoIID LytB domain protein GYO_4049 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GYO_4051 ENOG4106778 Protein of unknown function (DUF1146) GYO_4054 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GYO_4055 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GYO_4056 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GYO_4057 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GYO_4062 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) GYO_4064 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GYO_4065 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GYO_4066 ENOG4108UIC UPF0340 protein GYO_4067 ENOG4108YZG isomerase GYO_4069 ENOG4107WAU Protein tyrosine phosphatase GYO_4070 ENOG410815N Probably functions as a manganese efflux pump (By similarity) GYO_4071 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GYO_4076 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GYO_4077 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GYO_4078 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GYO_4080 ENOG4107TT2 Auxin Efflux Carrier GYO_4081 ENOG4105C6K Malic enzyme GYO_4082 ENOG4107104 thymidine kinase GYO_4083 ENOG41082DI 50s ribosomal protein l31 GYO_4084 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GYO_4086 ENOG4105CBT Fructose-1,6-bisphosphatase GYO_4087 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GYO_4089 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway GYO_4090 ENOG4105D2N Aldolase GYO_4091 ENOG410812K response regulator receiver protein GYO_4093 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GYO_4096 ENOG4105C1G acyl-Coa dehydrogenase GYO_4097 ENOG4105DF6 Fe-S oxidoreductase GYO_4099 ENOG4105E5J UV damage endonuclease GYO_4101 ENOG4105NAE bifunctional deaminase-reductase domain protein GYO_4102 ENOG4105BZ1 (ABC) transporter GYO_4103 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GYO_4106 ENOG4105R3A Nitrate reductase GYO_4107 ENOG4108IUE nitrate reductase beta subunit GYO_4112 ENOG4107V6Q Cyclic nucleotide-binding domain GYO_4114 ENOG4105C75 arginyL-tRNA synthetase GYO_4115 ENOG410684U Domain of unknown function (DUF1934) GYO_4117 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E GYO_4126 ENOG4107JM4 Tetratricopeptide repeat GYO_4131 ENOG4108RDQ ABC transporter GYO_4133 ENOG4105CYW agmatinase GYO_4134 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GYO_4135 ENOG4105BZ4 penicillin-binding protein GYO_4137 ENOG4108XFG YwhD family GYO_4138 ENOG4108Z4T Peptidase M50 GYO_4139 ENOG41069HH 4-oxalocrotonate tautomerase GYO_4140 ENOG41067TZ transcriptional regulator, MarR family GYO_4141 ENOG4105C22 threonyL-tRNA synthetase GYO_4146 ENOG4105DCI Phosphohydrolase GYO_4148 ENOG4108VCI transcription factor, rsfa family GYO_4149 ENOG4108RNG Permease of the drug metabolite transporter GYO_4150 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GYO_4151 ENOG4105DUM transcriptional regulator, lysR family GYO_4152 ENOG4108IJ2 phosphate acetyltransferase GYO_4155 ENOG4105CHM Aminotransferase GYO_4157 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase GYO_4158 ENOG4105CHR reductase GYO_4159 ENOG4106CHD Bacilysin biosynthesis protein bacB GYO_4160 ENOG41061WN bacilysin biosynthesis protein GYO_4161 ENOG4105FCW Major Facilitator superfamily GYO_4164 ENOG4105C26 Dehydrogenase GYO_4166 ENOG4105D82 Glutamate dehydrogenase GYO_4170 ENOG4105C1B dTDP-glucose 4-6-dehydratase GYO_4171 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GYO_4173 ENOG4107TY6 Acylneuraminate cytidylyltransferase GYO_4175 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD GYO_4176 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GYO_4185 ENOG4105C26 Dehydrogenase GYO_4186 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GYO_4187 ENOG4108RJ9 Glycosyl transferase, family 2 GYO_4192 ENOG4105DWF phosphomethylpyrimidine kinase GYO_4195 ENOG4105C5Y PTS System GYO_4196 ENOG4108QTI )-transporter GYO_4199 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GYO_4200 ENOG4105DEN Luciferase family GYO_4201 ENOG4108DBC nitroreductase GYO_4211 ENOG4107BMA Transglycosylase associated protein GYO_4213 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GYO_4214 ENOG4105WH5 Teichoic acid glycosylation protein GYO_4219 ENOG4107ZXU DSBA oxidoreductase GYO_4220 ENOG4105DBE peroxidase GYO_4221 ENOG410650H (LipO)protein GYO_4222 ENOG4107SJW iron permease, FTR1 GYO_4224 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GYO_4226 ENOG4105CMU LysR family (Transcriptional regulator GYO_4227 ENOG4105VAW lrga family GYO_4228 ENOG41067MG lrgb family GYO_4232 ENOG4105DR4 Methyltransferase GYO_4234 ENOG4108YV3 Protein of unknown function (DUF2711) GYO_4235 ENOG4105CK1 PTS System GYO_4237 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin GYO_4240 ENOG4105X1N Glycosyl transferase family 8 GYO_4242 ENOG4105GVJ transcriptional regulator GYO_4243 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GYO_4245 ENOG4105IIU Aminopeptidase GYO_4247 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GYO_4251 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) GYO_4252 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GYO_4254 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GYO_4255 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GYO_4256 ENOG4105CM2 brancheD-chain amino acid aminotransferase GYO_4257 ENOG4105F8D glycoside hydrolase family 4 GYO_4258 ENOG4105VCP PTS System GYO_4259 ENOG4105CK1 PTS System GYO_4260 ENOG4105VZJ PTS System GYO_4261 ENOG4105EMD TRANSCRIPTIONal GYO_4263 ENOG4108VX5 3-methyladenine DNA glycosylase GYO_4264 ENOG4105CH6 catalase GYO_4267 ENOG4105DA5 (ABC) transporter GYO_4268 ENOG41069JR GYO_4272 ENOG4105ETS cytosine purines uracil thiamine allantoin GYO_4273 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GYO_4274 ENOG4108JJ8 (ABC) transporter GYO_4275 ENOG4108JJ9 ABC, transporter GYO_4276 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GYO_4277 ENOG4105C4M (Ubiquinol oxidase) subunit I GYO_4278 ENOG4105D2K citrate carrier protein GYO_4281 ENOG4107BJW polysaccharide deacetylase GYO_4288 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GYO_4290 ENOG4105CMR udp-glucose 4-epimerase GYO_4293 ENOG4105BZU Histidine kinase GYO_4294 ENOG4105WH1 Two component transcriptional regulator luxr family GYO_4295 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GYO_4302 ENOG4105DTD Dehydrogenase GYO_4303 ENOG4108IIH CoA-transferase subunit B GYO_4304 ENOG4105D6N CoA-transferase, subunit a GYO_4305 ENOG4105CY2 Citrate transporter GYO_4306 ENOG4105DHI Methyltransferase GYO_4310 ENOG4105CH6 catalase GYO_4311 ENOG4105D4T Citrate transporter GYO_4312 ENOG410900G Protein of unknown function (DUF421) GYO_4314 ENOG4105CS2 ec 3.2.1.21 GYO_4315 ENOG4105C5Y PTS System GYO_4317 ENOG4105CID antiterminator GYO_4320 ENOG4105DEU major facilitator superfamily GYO_4321 ENOG4105C1J atp-dependent rna helicase GYO_4322 ENOG4107TDE lipolytic protein G-D-S-L family GYO_4332 ENOG4107YZX Universal stress protein GYO_4333 ENOG4105CS2 ec 3.2.1.21 GYO_4334 ENOG4105C5Y PTS System GYO_4336 ENOG4107EV6 Inherit from COG: YD repeat protein GYO_4339 ENOG4106Z5D Glycoside Hydrolase Family 43 GYO_4342 ENOG4105C84 Histidine ammonia-lyase GYO_4343 ENOG4105CGP Urocanate hydratase GYO_4344 ENOG4105CI2 imidazolone-5-propionate hydrolase GYO_4345 ENOG4107W25 arginase agmatinase formiminoglutamase GYO_4347 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GYO_4348 ENOG4105D9N nucleoside GYO_4351 ENOG4107RHR regulatoR GYO_4352 ENOG4108TM9 integral membrane protein GYO_4353 ENOG4105ENY Ethanolamine utilization protein eutH GYO_4354 ENOG4108PGP mmge prpd family protein GYO_4355 ENOG4105CH2 amidohydrolase GYO_4357 ENOG4108HW4 amino acid AbC transporter GYO_4358 ENOG4105EAB amino acid AbC transporter GYO_4359 ENOG4108XSB acetyltransferase, (GNAT) family GYO_4360 ENOG4105CPU Monooxygenase GYO_4361 ENOG4107QHE Choloylglycine hydrolase GYO_4362 ENOG410667J hydrolase GYO_4368 ENOG4108V5C ABC transporter GYO_4374 ENOG4105D2N Aldolase GYO_4375 ENOG4105WZ4 isomerase GYO_4376 ENOG4105F0H myo-inositol catabolism protein GYO_4377 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GYO_4379 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GYO_4380 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GYO_4381 ENOG4105D7K pfkb domain protein GYO_4383 ENOG4105C26 Dehydrogenase GYO_4385 ENOG4105CPC Aldo Keto reductase GYO_4388 ENOG4107QNK )-transporter GYO_4389 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GYO_4391 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GYO_4392 ENOG4105ST3 Transcriptional regulator GYO_4393 ENOG4105C26 Dehydrogenase GYO_4394 ENOG41085PJ rdd domain containing protein GYO_4396 ENOG41085PJ rdd domain containing protein GYO_4399 ENOG4105J7D transcriptional regulator GYO_4400 ENOG4107JEE Short-chain dehydrogenase reductase Sdr GYO_4401 ENOG41061AU MarR family Transcriptional regulator GYO_4403 ENOG41067MG lrgb family GYO_4407 ENOG4105BZW Glycerate kinase GYO_4408 ENOG4105G3Z GntR family transcriptional regulator GYO_4409 ENOG4105CMG Carbohydrate kinase GYO_4410 ENOG4105C6Z Gluconate GYO_4411 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GYO_4413 ENOG4105D3R alkyl hydroperoxide reductase GYO_4414 ENOG4108JU3 Alkyl hydroperoxide reductase GYO_4415 ENOG4107R3N Filamentation induced by cAMP protein fic GYO_4418 ENOG4105CS2 ec 3.2.1.21 GYO_4420 ENOG4108S3Y transcriptional regulator GYO_4422 ENOG4106KKU GYO_4423 ENOG4108Z15 abc transporter atp-binding protein GYO_4425 ENOG4105Y2Z radical SAM domain protein GYO_4427 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 GYO_4431 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GYO_4433 ENOG4105E2A Dehydrogenase GYO_4437 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) GYO_4438 ENOG4105WQG acetyltransferase GYO_4439 ENOG410780I phosphoprotein phosphatase activity GYO_4441 ENOG41066UZ arginase EC 3.5.3.1 GYO_4442 ENOG4108IQI permease GYO_4443 ENOG4105C8Y Acetylornithine aminotransferase GYO_4444 ENOG4108JUB Transcriptional regulator GYO_4445 ENOG4105BZU Histidine kinase GYO_4449 ENOG4105C0H protease GYO_4450 ENOG4105Q2H domain protein GYO_4453 ENOG4105BZU Histidine kinase GYO_4454 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYO_4459 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GYO_4460 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GYO_4462 ENOG4105CDU Replicative dna helicase GYO_4466 ENOG4105DJ2 Major Facilitator Superfamily GYO_4467 ENOG4105EDW glycosyl transferase, family 39 GYO_4468 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GYO_4469 ENOG4105BZR domain protein GYO_4470 ENOG4108XMW Membrane GYO_4473 ENOG4105KVH Transcriptional regulator GYO_4474 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GYO_4478 ENOG41090E6 transcriptional regulator MERR family GYO_4480 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein GYO_4481 ENOG4105DDN Pentapeptide repeat-containing protein GYO_4482 ENOG4105D94 Major Facilitator Superfamily GYO_4483 ENOG4107RSM transcriptional regulator GYO_4484 ENOG41082BV acetyltransferase GYO_4485 ENOG41081I9 integral membrane protein GYO_4488 ENOG4105KVH Transcriptional regulator GYO_4490 ENOG4108U05 Transcriptional regulator GYO_4491 ENOG41082BV acetyltransferase GYO_4495 ENOG4105WAB arsR family transcriptional regulator GYO_4496 ENOG4105C7Z Conserved Protein GYO_4497 ENOG4107FCW Abortive infection protein GYO_4499 ENOG4108UW5 maltose o-acetyltransferase GYO_4500 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GYO_4502 ENOG4105CGK Exodeoxyribonuclease III GYO_4503 ENOG4108UUM single-stranded DNA-binding protein GYO_4504 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GYO_4505 ENOG4105C3G gtp-binding protein GYO_4506 ENOG4105C3G gtp-binding protein GYO_4507 ENOG4108J2R molybdopterin oxidoreductase GYO_4508 ENOG4105VDK protein, conserved in bacteria GYO_4510 ENOG4108ZDA Sporulation protein YyaC GYO_4511 ENOG4105FA0 parb-like partition protein GYO_4512 ENOG4107QJE Chromosome Partitioning Protein GYO_4515 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GYO_4516 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GYO_4517 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GYO_4520 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GYO_4551 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GYO_4555 ENOG4105FKZ Methyl-accepting chemotaxis GYO_4556 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GYO_4557 ENOG4107DZX Small, acid-soluble spore protein P GYO_4558 ENOG4105C7N Xanthine uracil vitamin C permease