locus-tag	class	description
NP434_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NP434_00010	COG0592	DNA-directed DNA polymerase activity
NP434_00015	COG2501	S4 domain
NP434_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NP434_00030	COG0187	DNA topoisomerase II activity
NP434_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP434_00070	COG0516	GMP reductase activity
NP434_00070	COG0517	IMP dehydrogenase activity
NP434_00075	COG1686	Belongs to the peptidase S11 family
NP434_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NP434_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NP434_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NP434_00100	COG1428	Deoxynucleoside kinase
NP434_00105	COG1428	Deoxynucleoside kinase
NP434_00110	COG1388	LysM domain
NP434_00110	COG3858	chitin binding
NP434_00115	COG1335	isochorismatase
NP434_00120	COG0590	tRNA wobble adenosine to inosine editing
NP434_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NP434_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NP434_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NP434_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NP434_00190	COG3853	Toxic anion resistance protein (TelA)
NP434_00195	COG1982	Orn Lys Arg decarboxylase major
NP434_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NP434_00205	COG3870	Protein conserved in bacteria
NP434_00210	COG1728	Protein conserved in bacteria
NP434_00215	COG0470	DNA polymerase III
NP434_00220	COG1774	PSP1 C-terminal conserved region
NP434_00225	COG4467	Involved in initiation control of chromosome replication
NP434_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NP434_00235	COG2827	Endonuclease containing a URI domain
NP434_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NP434_00245	COG2002	toxin-antitoxin pair type II binding
NP434_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP434_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP434_00255	COG0084	hydrolase, TatD family'
NP434_00260	COG3583	domain protein
NP434_00260	COG3584	3D domain protein
NP434_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP434_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NP434_00280	COG4466	Protein conserved in bacteria
NP434_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NP434_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP434_00300	COG0251	oxidation-reduction process
NP434_00305	COG2088	sporulation resulting in formation of a cellular spore
NP434_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NP434_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NP434_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NP434_00325	COG0193	aminoacyl-tRNA hydrolase activity
NP434_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NP434_00340	COG2002	toxin-antitoxin pair type II binding
NP434_00345	COG2244	polysaccharide biosynthetic process
NP434_00350	COG3956	TIGRFAM MazG family protein
NP434_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NP434_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NP434_00375	COG1098	S1 RNA binding domain
NP434_00390	COG2208	phosphoserine phosphatase activity
NP434_00395	COG2304	oxidoreductase activity
NP434_00400	COG0515	serine threonine protein kinase
NP434_00405	COG0037	tRNA processing
NP434_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NP434_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP434_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NP434_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NP434_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP434_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP434_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP434_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
NP434_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP434_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NP434_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NP434_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP434_00470	COG1396	sequence-specific DNA binding
NP434_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP434_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NP434_00560	COG4463	regulation of RNA biosynthetic process
NP434_00565	COG3880	PFAM UvrB UvrC protein
NP434_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
NP434_00575	COG0542	response to heat
NP434_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NP434_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NP434_00590	COG4956	integral membrane protein (PIN domain superfamily)
NP434_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NP434_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NP434_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP434_00610	COG1045	serine acetyltransferase
NP434_00615	COG0215	cysteine-tRNA ligase activity
NP434_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NP434_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP434_00630	COG3688	RNA-binding protein containing a PIN domain
NP434_00635	COG1595	DNA-templated transcription, initiation
NP434_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP434_00650	COG0250	Participates in transcription elongation, termination and antitermination
NP434_00660	COG0081	regulation of translation
NP434_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NP434_00675	COG2813	Specifically methylates the guanine in position
NP434_00680	COG0085	RNA polymerase activity
NP434_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NP434_00690	COG1358	cellular component organization or biogenesis
NP434_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NP434_00700	COG0049	tRNA binding
NP434_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP434_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NP434_00715	COG0596	Alpha beta hydrolase
NP434_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NP434_00730	COG0088	Forms part of the polypeptide exit tunnel
NP434_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NP434_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NP434_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NP434_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NP434_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NP434_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NP434_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NP434_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NP434_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NP434_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NP434_00820	COG0200	Binds to the 23S rRNA
NP434_00825	COG0201	protein transport
NP434_00830	COG0563	adenylate kinase activity
NP434_00835	COG0024	Methionine aminopeptidase
NP434_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
NP434_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NP434_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NP434_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NP434_00865	COG0202	RNA polymerase activity
NP434_00870	COG0203	ribosomal protein L17
NP434_00875	COG1122	ATPase activity
NP434_00880	COG1122	ATPase activity
NP434_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP434_00890	COG0101	tRNA pseudouridine synthase activity
NP434_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NP434_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NP434_00905	COG2226	methyltransferase
NP434_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP434_00920	COG0489	protein tyrosine kinase activity
NP434_00930	COG2194	sulfuric ester hydrolase activity
NP434_00935	COG0726	polysaccharide deacetylase
NP434_00985	COG1395	domain, Protein
NP434_01070	COG5444	nuclease activity
NP434_01140	COG0659	secondary active sulfate transmembrane transporter activity
NP434_01145	COG0385	Bile acid
NP434_01150	COG2819	hydrolase of the alpha beta superfamily
NP434_01155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_01160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_01165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP434_01170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP434_01170	COG2207	Transcriptional regulator
NP434_01175	COG3876	Protein conserved in bacteria
NP434_01180	COG1472	Belongs to the glycosyl hydrolase 3 family
NP434_01185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP434_01190	COG1263	PTS System
NP434_01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_01195	COG1737	Transcriptional regulator
NP434_01200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NP434_01205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP434_01210	COG1683	Conserved Protein
NP434_01240	COG1595	DNA-templated transcription, initiation
NP434_01245	COG5662	AntiSigma factor
NP434_01250	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP434_01255	COG4856	YbbR-like protein
NP434_01260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP434_01265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NP434_01275	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NP434_01280	COG2169	Transcriptional regulator
NP434_01285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP434_01290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP434_01295	COG3002	Belongs to the UPF0753 family
NP434_01300	COG0288	reversible hydration of carbon dioxide
NP434_01310	COG5609	conserved protein (DUF2294)
NP434_01315	COG0640	Transcriptional regulator
NP434_01320	COG2814	Major facilitator Superfamily
NP434_01335	COG0596	Alpha beta hydrolase
NP434_01340	COG0745	RESPONSE REGULATOR receiver
NP434_01345	COG0642	Histidine kinase
NP434_01355	COG0515	serine threonine protein kinase
NP434_01370	COG1113	amino acid transport
NP434_01385	COG2602	Beta-lactamase
NP434_01390	COG2124	cytochrome p450
NP434_01400	COG0531	amino acid
NP434_01405	COG0584	glycerophosphoryl diester phosphodiesterase
NP434_01410	COG2271	Major facilitator Superfamily
NP434_01420	COG0456	acetyltransferase
NP434_01420	COG1846	Transcriptional regulator
NP434_01425	COG2271	Major facilitator Superfamily
NP434_01435	COG3409	Peptidoglycan-binding domain 1 protein
NP434_01440	COG0697	spore germination
NP434_01445	COG1917	Cupin 2, conserved barrel domain protein
NP434_01445	COG2207	Transcriptional regulator
NP434_01450	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NP434_01455	COG3591	Belongs to the peptidase S1B family
NP434_01465	COG0596	Alpha beta hydrolase
NP434_01470	COG1183	phosphatidylcholine synthase activity
NP434_01475	COG0586	Pfam SNARE associated Golgi protein
NP434_01480	COG0688	phosphatidylethanolamine metabolic process
NP434_01490	COG2312	Erythromycin esterase
NP434_01495	COG1054	Belongs to the UPF0176 family
NP434_01500	COG1301	dicarboxylic acid transport
NP434_01505	COG2190	(PTS) system
NP434_01505	COG1263	PTS System
NP434_01505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_01510	COG0363	glucosamine-6-phosphate deaminase activity
NP434_01515	COG2188	Transcriptional regulator
NP434_01525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP434_01530	COG0833	amino acid
NP434_01535	COG2040	homocysteine
NP434_01540	COG1115	amino acid carrier protein
NP434_01545	COG2066	Belongs to the glutaminase family
NP434_01550	COG4191	Histidine kinase
NP434_01555	COG0784	Response regulator, receiver
NP434_01560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP434_01565	COG1012	belongs to the aldehyde dehydrogenase family
NP434_01570	COG2271	Major facilitator Superfamily
NP434_01575	COG4948	Mandelate Racemase Muconate Lactonizing
NP434_01580	COG2186	Transcriptional regulator
NP434_01585	COG2721	sulfolactate sulfo-lyase activity
NP434_01590	COG3173	Aminoglycoside phosphotransferase
NP434_01600	COG0697	spore germination
NP434_01605	COG0745	RESPONSE REGULATOR receiver
NP434_01610	COG2205	protein histidine kinase activity
NP434_01615	COG1131	(ABC) transporter
NP434_01635	COG3773	Cell wall hydrolase
NP434_01640	COG2304	oxidoreductase activity
NP434_01650	COG3540	Alkaline phosphatase
NP434_01655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP434_01660	COG0805	protein transport
NP434_01665	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NP434_01670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP434_01675	COG0477	Major facilitator Superfamily
NP434_01680	COG1309	transcriptional regulator
NP434_01685	COG0252	asparaginase activity
NP434_01690	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NP434_01695	COG1714	RDD family
NP434_01700	COG1405	negative regulation of cell septum assembly
NP434_01700	COG3012	SEC-C Motif Domain Protein
NP434_01705	COG3290	protein histidine kinase activity
NP434_01710	COG3279	Response regulator of the LytR AlgR family
NP434_01715	COG4555	ABC transporter
NP434_01720	COG1668	transmembrane transport
NP434_01725	COG0667	Aldo Keto reductase
NP434_01740	COG1595	DNA-templated transcription, initiation
NP434_01745	COG1595	DNA-templated transcription, initiation
NP434_01750	COG1876	peptidase activity
NP434_01755	COG0457	Tetratricopeptide repeat
NP434_01760	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_01765	COG0366	Alpha amylase catalytic
NP434_01770	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP434_01775	COG1121	(ABC) transporter
NP434_01780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP434_01785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP434_01790	COG2310	stress, protein
NP434_01795	COG2310	stress, protein
NP434_01800	COG2310	stress, protein
NP434_01805	COG0861	Integral membrane protein TerC family
NP434_01815	COG3853	Toxic anion resistance protein (TelA)
NP434_01820	COG0477	Major facilitator Superfamily
NP434_01825	COG2814	Major facilitator Superfamily
NP434_01830	COG0640	Transcriptional regulator
NP434_01835	COG0517	IMP dehydrogenase activity
NP434_01835	COG4175	Glycine betaine
NP434_01840	COG4176	ABC-type proline glycine betaine transport system permease component
NP434_01845	COG2113	Glycine betaine
NP434_01850	COG1473	amidohydrolase
NP434_01855	COG1288	antiporter activity
NP434_01865	COG0366	Alpha amylase catalytic
NP434_01870	COG0039	L-malate dehydrogenase activity
NP434_01875	COG1620	l-lactate permease
NP434_01880	COG2814	Major facilitator Superfamily
NP434_01885	COG1846	Transcriptional regulator
NP434_01890	COG1280	lysine exporter protein (LysE YggA)
NP434_01895	COG3403	YqcI/YcgG family
NP434_01900	COG1113	amino acid transport
NP434_01905	COG3665	Urea carboxylase-associated protein
NP434_01910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NP434_01915	COG1660	Displays ATPase and GTPase activities
NP434_01920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NP434_01925	COG2226	methyltransferase
NP434_01930	COG0583	DNA-binding transcription factor activity
NP434_01935	COG3458	cephalosporin-C deacetylase activity
NP434_01940	COG3541	Predicted nucleotidyltransferase
NP434_01945	COG0506	proline dehydrogenase activity
NP434_01950	COG1012	belongs to the aldehyde dehydrogenase family
NP434_01955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP434_01960	COG2508	Transcriptional regulator
NP434_01965	COG3689	TIGRFAM TIGR03943 family protein
NP434_01970	COG0701	Predicted permease
NP434_01975	COG2267	carboxylic ester hydrolase activity
NP434_01980	COG0492	ferredoxin-NADP+ reductase activity
NP434_01985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP434_01985	COG1587	Uroporphyrinogen-III synthase
NP434_01990	COG2146	nitrite reductase [NAD(P)H] activity
NP434_01995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP434_02000	COG0243	molybdopterin cofactor binding
NP434_02005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP434_02010	COG2223	nitrite transmembrane transporter activity
NP434_02015	COG1469	GTP cyclohydrolase I activity
NP434_02035	COG0523	cobalamin synthesis protein
NP434_02040	COG0765	amino acid transport
NP434_02045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP434_02065	COG1846	Transcriptional regulator
NP434_02075	COG3842	ATPase activity
NP434_02080	COG2723	6-phospho-beta-galactosidase activity
NP434_02090	COG3209	COG3209 Rhs family protein
NP434_02095	COG0840	transmembrane signaling receptor activity
NP434_02095	COG3290	protein histidine kinase activity
NP434_02100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NP434_02105	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NP434_02110	COG1733	regulation of RNA biosynthetic process
NP434_02115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_02135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_02140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_02145	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NP434_02150	COG2814	Major facilitator Superfamily
NP434_02160	COG0697	spore germination
NP434_02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP434_02175	COG2364	Membrane
NP434_02180	COG1126	abc transporter atp-binding protein
NP434_02185	COG0765	amino acid transport
NP434_02190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP434_02195	COG0583	DNA-binding transcription factor activity
NP434_02200	COG0163	prenyltransferase activity
NP434_02205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NP434_02220	COG0596	Alpha beta hydrolase
NP434_02225	COG3104	oligopeptide transport
NP434_02230	COG5434	Belongs to the glycosyl hydrolase 28 family
NP434_02240	COG0697	spore germination
NP434_02250	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NP434_02255	COG1136	(ABC) transporter
NP434_02260	COG0577	efflux transmembrane transporter activity
NP434_02265	COG0745	RESPONSE REGULATOR receiver
NP434_02270	COG3850	Histidine kinase
NP434_02270	COG5002	protein histidine kinase activity
NP434_02275	COG0457	Tetratricopeptide repeat
NP434_02295	COG0527	aspartate kinase activity
NP434_02300	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_02305	COG4605	iron ion homeostasis
NP434_02310	COG4604	ABC transporter, ATP-binding protein
NP434_02315	COG4607	ABC-type enterochelin transport system periplasmic component
NP434_02320	COG2814	Major facilitator Superfamily
NP434_02325	COG1309	transcriptional regulator
NP434_02330	COG0778	Nitroreductase
NP434_02335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NP434_02340	COG0640	Transcriptional regulator
NP434_02345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP434_02350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP434_02355	COG1012	belongs to the aldehyde dehydrogenase family
NP434_02360	COG4975	Glucose uptake
NP434_02365	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_02370	COG4549	nuclear export factor GLE1
NP434_02375	COG1276	copper resistance
NP434_02375	COG2372	response to copper ion
NP434_02380	COG1349	DNA-binding transcription factor activity
NP434_02390	COG2213	PTS system mannitol-specific
NP434_02395	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP434_02400	COG0246	Mannitol dehydrogenase
NP434_02405	COG0473	3-isopropylmalate dehydrogenase activity
NP434_02410	COG0681	Belongs to the peptidase S26 family
NP434_02415	COG0412	Dienelactone hydrolase
NP434_02420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP434_02430	COG0561	phosphatase activity
NP434_02435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NP434_02440	COG1914	H( )-stimulated, divalent metal cation uptake system
NP434_02445	COG4336	lyase activity
NP434_02450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NP434_02455	COG1984	allophanate hydrolase subunit 2
NP434_02460	COG1414	Transcriptional regulator
NP434_02465	COG2755	lipolytic protein G-D-S-L family
NP434_02475	COG2329	Antibiotic biosynthesis monooxygenase
NP434_02480	COG0768	penicillin binding
NP434_02485	COG4989	oxidoreductase activity
NP434_02490	COG3711	transcriptional antiterminator
NP434_02495	COG0318	PFAM AMP-dependent synthetase and ligase
NP434_02500	COG2226	methyltransferase
NP434_02505	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_02510	COG1917	Cupin 2, conserved barrel domain protein
NP434_02515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP434_02520	COG3871	stress protein (general stress protein 26)
NP434_02530	COG2814	Major facilitator Superfamily
NP434_02535	COG1522	sequence-specific DNA binding
NP434_02540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP434_02540	COG0551	DNA topoisomerase type I activity
NP434_02545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NP434_02550	COG3706	GGDEF domain
NP434_02555	COG5298	Protein conserved in bacteria
NP434_02560	COG1215	transferase activity, transferring glycosyl groups
NP434_02570	COG0531	amino acid
NP434_02580	COG0028	Belongs to the TPP enzyme family
NP434_02595	COG1914	H( )-stimulated, divalent metal cation uptake system
NP434_02600	COG2261	transglycosylase associated protein
NP434_02605	COG4876	unkown
NP434_02610	COG2217	Heavy metal translocating P-type atpase
NP434_02615	COG3729	General stress protein
NP434_02620	COG0662	Cupin 2, conserved barrel domain protein
NP434_02625	COG2329	Antibiotic biosynthesis monooxygenase
NP434_02630	COG3546	catalase activity
NP434_02635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP434_02640	COG3290	protein histidine kinase activity
NP434_02645	COG4565	transcriptional regulatory protein
NP434_02650	COG1301	dicarboxylic acid transport
NP434_02655	COG0628	permease
NP434_02660	COG1131	(ABC) transporter
NP434_02665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP434_02675	COG1960	acyl-CoA dehydrogenase activity
NP434_02690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP434_02695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP434_02700	COG1181	Belongs to the D-alanine--D-alanine ligase family
NP434_02705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NP434_02710	COG0513	Belongs to the DEAD box helicase family
NP434_02715	COG3402	PFAM membrane-flanked domain
NP434_02720	COG3428	Bacterial PH domain
NP434_02725	COG0705	Rhomboid family
NP434_02730	COG0736	holo-[acyl-carrier-protein] synthase activity
NP434_02735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NP434_02740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP434_02745	COG0864	Transcriptional regulator
NP434_02750	COG2337	Toxic component of a toxin-antitoxin (TA) module
NP434_02755	COG1366	Belongs to the anti-sigma-factor antagonist family
NP434_02760	COG1366	Belongs to the anti-sigma-factor antagonist family
NP434_02765	COG2172	sigma factor antagonist activity
NP434_02770	COG2208	phosphoserine phosphatase activity
NP434_02775	COG1366	Belongs to the anti-sigma-factor antagonist family
NP434_02780	COG2172	sigma factor antagonist activity
NP434_02785	COG1191	sigma factor activity
NP434_02790	COG2208	phosphoserine phosphatase activity
NP434_02795	COG2183	response to ionizing radiation
NP434_02805	COG3091	SprT-like family
NP434_02845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP434_02855	COG5444	nuclease activity
NP434_02860	COG1476	TRANSCRIPTIONal
NP434_02870	COG3239	Fatty acid desaturase
NP434_02875	COG1278	Cold shock
NP434_02880	COG1329	Transcriptional regulator
NP434_02885	COG0697	spore germination
NP434_02890	COG2207	Transcriptional regulator
NP434_02890	COG1917	Cupin 2, conserved barrel domain protein
NP434_02895	COG0697	spore germination
NP434_02905	COG1309	transcriptional regulator
NP434_02915	COG2814	Major facilitator Superfamily
NP434_02925	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
NP434_02930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP434_02935	COG1309	transcriptional regulator
NP434_02940	COG2207	Transcriptional regulator
NP434_02940	COG3708	Transcriptional regulator
NP434_02945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NP434_02950	COG1522	sequence-specific DNA binding
NP434_02955	COG0697	spore germination
NP434_02960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP434_02965	COG2030	dehydratase
NP434_02970	COG3545	Serine hydrolase
NP434_02975	COG1733	regulation of RNA biosynthetic process
NP434_02980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP434_02985	COG1733	regulation of RNA biosynthetic process
NP434_02990	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP434_02995	COG2814	Major facilitator Superfamily
NP434_03000	COG1309	transcriptional regulator
NP434_03005	COG0640	Transcriptional regulator
NP434_03010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP434_03020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP434_03025	COG0697	spore germination
NP434_03030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP434_03035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP434_03040	COG0640	Transcriptional regulator
NP434_03045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NP434_03060	COG4585	Histidine kinase
NP434_03065	COG2197	response regulator
NP434_03070	COG2409	Drug exporters of the RND superfamily
NP434_03075	COG0596	Alpha beta hydrolase
NP434_03080	COG1811	Na channel or pump
NP434_03085	COG4978	Transcriptional regulator
NP434_03085	COG0789	Transcriptional regulator
NP434_03090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP434_03095	COG0778	Nitroreductase
NP434_03100	COG0346	lactoylglutathione lyase activity
NP434_03105	COG2259	Doxx family
NP434_03110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP434_03130	COG2323	membrane
NP434_03135	COG2323	membrane
NP434_03140	COG0071	Belongs to the small heat shock protein (HSP20) family
NP434_03155	COG1309	transcriptional regulator
NP434_03165	COG0456	acetyltransferase
NP434_03170	COG0488	(ABC) transporter
NP434_03175	COG1113	amino acid transport
NP434_03180	COG2318	DinB family
NP434_03185	COG1846	Transcriptional regulator
NP434_03190	COG1033	growth of symbiont in host cell
NP434_03190	COG2409	Drug exporters of the RND superfamily
NP434_03195	COG0778	Nitroreductase
NP434_03200	COG1846	Transcriptional regulator
NP434_03205	COG2814	Major facilitator Superfamily
NP434_03210	COG0730	response to heat
NP434_03215	COG1802	Transcriptional regulator
NP434_03220	COG3858	chitin binding
NP434_03220	COG1388	LysM domain
NP434_03225	COG1819	glycosyl
NP434_03235	COG1785	Belongs to the alkaline phosphatase family
NP434_03240	COG5646	InterPro IPR014922
NP434_03250	COG0454	-acetyltransferase
NP434_03255	COG1078	dGTPase activity
NP434_03260	COG1388	LysM domain
NP434_03265	COG2814	Major facilitator Superfamily
NP434_03270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP434_03275	COG1447	Phosphotransferase system cellobiose-specific component IIA
NP434_03280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP434_03285	COG2723	6-phospho-beta-galactosidase activity
NP434_03290	COG2188	Transcriptional regulator
NP434_03295	COG1940	carbohydrate kinase activity
NP434_03300	COG1482	cell wall glycoprotein biosynthetic process
NP434_03305	COG4124	Belongs to the glycosyl hydrolase 26 family
NP434_03350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NP434_03355	COG0802	atpase or kinase
NP434_03360	COG1214	PFAM Peptidase M22, glycoprotease
NP434_03365	COG0456	acetyltransferase
NP434_03370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NP434_03375	COG0488	(ABC) transporter
NP434_03380	COG0315	cyclic pyranopterin monophosphate synthase activity
NP434_03385	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NP434_03390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP434_03395	COG0805	protein transport
NP434_03405	COG1266	CAAX protease self-immunity
NP434_03415	COG0459	protein refolding
NP434_03420	COG1073	alpha beta
NP434_03425	COG0457	Tetratricopeptide repeat
NP434_03430	COG1063	alcohol dehydrogenase
NP434_03435	COG2211	Major facilitator Superfamily
NP434_03440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP434_03445	COG1842	Phage shock protein A
NP434_03450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP434_03455	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NP434_03460	COG4260	virion core protein, lumpy skin disease virus
NP434_03470	COG2814	Major facilitator Superfamily
NP434_03475	COG1063	alcohol dehydrogenase
NP434_03480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NP434_03485	COG0823	Involved in the tonB-independent uptake of proteins
NP434_03500	COG2267	carboxylic ester hydrolase activity
NP434_03510	COG2132	Multicopper oxidase
NP434_03515	COG1113	amino acid transport
NP434_03530	COG0714	Associated with various cellular activities
NP434_03535	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NP434_03540	COG1305	Transglutaminase-like
NP434_03545	COG0519	Catalyzes the synthesis of GMP from XMP
NP434_03545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NP434_03565	COG2252	PERMEase
NP434_03570	COG3064	Membrane
NP434_03580	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
NP434_03590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NP434_03595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NP434_03600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NP434_03605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NP434_03610	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP434_03615	COG0047	phosphoribosylformylglycinamidine synthase activity
NP434_03620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP434_03625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NP434_03630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NP434_03635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NP434_03640	COG0138	bifunctional purine biosynthesis protein purh
NP434_03645	COG0151	Belongs to the GarS family
NP434_03650	COG1522	sequence-specific DNA binding
NP434_03655	COG0531	amino acid
NP434_03665	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP434_03670	COG1470	cell adhesion involved in biofilm formation
NP434_03675	COG4496	protein, YerC YecD
NP434_03680	COG0069	glutamate synthase activity
NP434_03685	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NP434_03690	COG0210	DNA helicase
NP434_03695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NP434_03700	COG4851	CamS sex pheromone cAM373 precursor
NP434_03705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP434_03710	COG1285	pathogenesis
NP434_03715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP434_03720	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP434_03725	COG0154	amidase activity
NP434_03730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP434_03740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP434_03745	COG1597	lipid kinase activity
NP434_03750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP434_03800	COG5444	nuclease activity
NP434_03805	COG3391	amine dehydrogenase activity
NP434_03810	COG0457	Tetratricopeptide repeat
NP434_03820	COG0217	transcriptional regulatory protein
NP434_03830	COG1309	transcriptional regulator
NP434_03835	COG3631	Ketosteroid isomerase-related protein
NP434_03855	COG3546	catalase activity
NP434_03860	COG0454	-acetyltransferase
NP434_03870	COG5578	integral membrane protein
NP434_03875	COG2972	Histidine kinase
NP434_03880	COG2207	Transcriptional regulator
NP434_03880	COG4753	response regulator
NP434_03885	COG1653	transport
NP434_03890	COG1175	transmembrane transport
NP434_03895	COG0395	ABC-type sugar transport system, permease component
NP434_03900	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NP434_03905	COG2207	Transcriptional regulator
NP434_03910	COG2755	lipolytic protein G-D-S-L family
NP434_03920	COG5578	integral membrane protein
NP434_03925	COG3401	FG-GAP repeat protein
NP434_03930	COG3401	FG-GAP repeat protein
NP434_03935	COG2755	lipolytic protein G-D-S-L family
NP434_03940	COG1874	Beta-galactosidase
NP434_03950	COG1653	transport
NP434_03955	COG4209	transmembrane transport
NP434_03960	COG0395	ABC-type sugar transport system, permease component
NP434_03965	COG1486	melibiose metabolic process
NP434_03970	COG2323	membrane
NP434_03975	COG2329	Antibiotic biosynthesis monooxygenase
NP434_03980	COG0346	lactoylglutathione lyase activity
NP434_03995	COG5583	Uncharacterized small protein (DUF2292)
NP434_04000	COG0670	Belongs to the BI1 family
NP434_04020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP434_04020	COG2124	cytochrome p450
NP434_04025	COG1368	sulfuric ester hydrolase activity
NP434_04030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NP434_04035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP434_04040	COG1442	glycosyl transferase family 8
NP434_04045	COG1216	Glycosyl transferase, family 2
NP434_04050	COG1442	glycosyl transferase family 8
NP434_04055	COG2223	nitrite transmembrane transporter activity
NP434_04060	COG1011	Hydrolase
NP434_04065	COG0531	amino acid
NP434_04070	COG1012	belongs to the aldehyde dehydrogenase family
NP434_04075	COG0840	transmembrane signaling receptor activity
NP434_04080	COG0488	(ABC) transporter
NP434_04090	COG0789	Transcriptional regulator
NP434_04095	COG2814	Major facilitator Superfamily
NP434_04110	COG0488	(ABC) transporter
NP434_04115	COG0513	Belongs to the DEAD box helicase family
NP434_04120	COG0456	acetyltransferase
NP434_04125	COG2130	NADP-dependent
NP434_04130	COG1120	ATPase activity
NP434_04135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_04140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_04145	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP434_04160	COG3866	Pectate lyase
NP434_04165	COG0471	metal ion transport
NP434_04170	COG3290	protein histidine kinase activity
NP434_04175	COG4565	transcriptional regulatory protein
NP434_04180	COG3181	Tripartite tricarboxylate transporter family receptor
NP434_04190	COG2851	Citrate transporter
NP434_04195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP434_04200	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NP434_04205	COG1254	Belongs to the acylphosphatase family
NP434_04210	COG2258	MOSC domain
NP434_04230	COG0024	Methionine aminopeptidase
NP434_04235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_04235	COG1263	PTS System
NP434_04240	COG1368	sulfuric ester hydrolase activity
NP434_04255	COG1115	amino acid carrier protein
NP434_04270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_04270	COG1263	PTS System
NP434_04275	COG0366	Alpha amylase catalytic
NP434_04280	COG2188	Transcriptional regulator
NP434_04285	COG0778	Nitroreductase
NP434_04290	COG0737	Belongs to the 5'-nucleotidase family
NP434_04295	COG0693	protein deglycase activity
NP434_04300	COG2814	Major facilitator Superfamily
NP434_04305	COG4840	Belongs to the UPF0435 family
NP434_04310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP434_04315	COG4980	gas vesicle protein
NP434_04320	COG1295	ribonuclease BN
NP434_04325	COG0477	Major facilitator Superfamily
NP434_04330	COG0387	Pfam Sodium calcium exchanger
NP434_04340	COG0668	transmembrane transport
NP434_04345	COG0535	radical SAM domain protein
NP434_04355	COG0726	polysaccharide deacetylase
NP434_04360	COG2084	Dehydrogenase
NP434_04365	COG0598	Magnesium transport protein CorA
NP434_04370	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NP434_04375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP434_04385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP434_04390	COG4637	Psort location Cytoplasmic, score
NP434_04400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP434_04405	COG0022	dehydrogenase e1 component
NP434_04410	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP434_04415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP434_04420	COG3284	Transcriptional regulator
NP434_04430	COG1742	UPF0060 membrane protein
NP434_04450	COG4842	Belongs to the WXG100 family
NP434_04455	COG1486	melibiose metabolic process
NP434_04460	COG1737	Transcriptional regulator
NP434_04465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_04465	COG1263	PTS System
NP434_04470	COG1132	(ABC) transporter
NP434_04475	COG1132	(ABC) transporter
NP434_04480	COG2259	Doxx family
NP434_04485	COG2514	catechol 2,3-dioxygenase activity
NP434_04490	COG4585	Histidine kinase
NP434_04495	COG2197	response regulator
NP434_04500	COG1131	(ABC) transporter
NP434_04505	COG0842	Transport permease protein
NP434_04505	COG1511	domain protein
NP434_04510	COG0842	Transport permease protein
NP434_04515	COG1695	Transcriptional regulator
NP434_04525	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
NP434_04530	COG2318	DinB family
NP434_04535	COG2814	Major facilitator Superfamily
NP434_04540	COG1846	Transcriptional regulator
NP434_04545	COG0392	lysyltransferase activity
NP434_04545	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NP434_04550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP434_04555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_04560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_04565	COG0384	phenazine biosynthesis protein PhzF
NP434_04570	COG0778	Nitroreductase
NP434_04585	COG1090	epimerase
NP434_04590	COG2137	regulation of response to DNA damage stimulus
NP434_04600	COG2814	Major facilitator Superfamily
NP434_04615	COG3103	Sh3 type 3 domain protein
NP434_04620	COG5658	integral membrane protein
NP434_04625	COG0596	Alpha beta hydrolase
NP434_04630	COG0463	Glycosyl transferase, family 2
NP434_04635	COG4485	Bacterial membrane protein, YfhO
NP434_04640	COG1988	membrane-bound metal-dependent
NP434_04645	COG1194	a g-specific adenine glycosylase
NP434_04655	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_04670	COG3557	Belongs to the UPF0374 family
NP434_04675	COG1132	(ABC) transporter
NP434_04680	COG4129	membrane
NP434_04685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP434_04690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NP434_04695	COG0735	belongs to the Fur family
NP434_04820	COG4326	sporulation control protein
NP434_04830	COG5577	PFAM Coat F domain
NP434_04840	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NP434_04845	COG0277	FAD linked oxidase domain protein
NP434_04855	COG0753	catalase activity
NP434_04860	COG1116	anion transmembrane transporter activity
NP434_04865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP434_04870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP434_04875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP434_04885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NP434_04895	COG1476	TRANSCRIPTIONal
NP434_04905	COG3382	B3 4 domain protein
NP434_04910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NP434_04920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NP434_04925	COG0789	Transcriptional regulator
NP434_04930	COG1664	Polymer-forming cytoskeletal
NP434_04935	COG1664	Polymer-forming cytoskeletal
NP434_04940	COG2766	serine protein kinase
NP434_04945	COG2718	Belongs to the UPF0229 family
NP434_04950	COG1846	Transcriptional regulator
NP434_04955	COG1566	PFAM secretion protein HlyD family protein
NP434_04960	COG2814	Major facilitator Superfamily
NP434_04965	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP434_04985	COG1725	Transcriptional regulator
NP434_04990	COG1131	(ABC) transporter
NP434_04995	COG1131	(ABC) transporter
NP434_05000	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP434_05005	COG1278	Cold shock
NP434_05010	COG1464	Belongs to the NlpA lipoprotein family
NP434_05015	COG3706	GGDEF domain
NP434_05020	COG1823	symporter activity
NP434_05040	COG5577	PFAM Coat F domain
NP434_05050	COG3764	Sortase (surface protein transpeptidase)
NP434_05055	COG0564	pseudouridine synthase activity
NP434_05065	COG0517	IMP dehydrogenase activity
NP434_05070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP434_05075	COG3153	acetyltransferase
NP434_05075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP434_05080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP434_05085	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NP434_05090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NP434_05095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NP434_05100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NP434_05105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP434_05110	COG2203	Gaf domain
NP434_05110	COG4585	Histidine kinase
NP434_05115	COG2197	response regulator
NP434_05120	COG0431	NADPH-dependent FMN reductase
NP434_05135	COG1388	LysM domain
NP434_05135	COG0791	NLP P60 protein
NP434_05140	COG1959	2 iron, 2 sulfur cluster binding
NP434_05145	COG0668	transmembrane transport
NP434_05150	COG2719	SpoVR family
NP434_05155	COG1785	Belongs to the alkaline phosphatase family
NP434_05160	COG0791	NLP P60 protein
NP434_05160	COG1388	LysM domain
NP434_05165	COG0583	DNA-binding transcription factor activity
NP434_05170	COG0372	Belongs to the citrate synthase family
NP434_05180	COG0531	amino acid
NP434_05185	COG0733	neurotransmitter:sodium symporter activity
NP434_05190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP434_05195	COG0456	acetyltransferase
NP434_05210	COG1595	DNA-templated transcription, initiation
NP434_05215	COG0667	Aldo Keto reductase
NP434_05220	COG0204	Acyl-transferase
NP434_05225	COG1253	flavin adenine dinucleotide binding
NP434_05230	COG0789	Transcriptional regulator
NP434_05235	COG0436	Aminotransferase
NP434_05240	COG1253	flavin adenine dinucleotide binding
NP434_05245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP434_05250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP434_05255	COG0584	glycerophosphoryl diester phosphodiesterase
NP434_05265	COG0668	transmembrane transport
NP434_05270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NP434_05275	COG0726	polysaccharide deacetylase
NP434_05280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP434_05285	COG1757	Na H antiporter
NP434_05290	COG0589	response to stress
NP434_05300	COG1132	(ABC) transporter
NP434_05305	COG1132	(ABC) transporter
NP434_05310	COG0702	epimerase
NP434_05330	COG0189	ligase activity
NP434_05335	COG0189	ligase activity
NP434_05340	COG4399	Belongs to the UPF0754 family
NP434_05345	COG3679	Belongs to the UPF0342 family
NP434_05350	COG4335	DNA alkylation repair
NP434_05355	COG0561	phosphatase activity
NP434_05360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP434_05365	COG0475	glutathione-regulated potassium exporter activity
NP434_05370	COG0490	domain, Protein
NP434_05380	COG1024	Enoyl-CoA hydratase
NP434_05390	COG4152	abc transporter atp-binding protein
NP434_05395	COG1668	transmembrane transport
NP434_05400	COG0420	3'-5' exonuclease activity
NP434_05405	COG4717	serine-type aminopeptidase activity
NP434_05410	COG3481	metal-dependent phosphohydrolase, HD sub domain
NP434_05420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP434_05450	COG1846	Transcriptional regulator
NP434_05455	COG4980	gas vesicle protein
NP434_05470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NP434_05475	COG0537	adenosine 5'-monophosphoramidase activity
NP434_05480	COG1131	(ABC) transporter
NP434_05485	COG4473	ABC transporter
NP434_05495	COG1473	amidohydrolase
NP434_05500	COG3069	C4-dicarboxylate transmembrane transporter activity
NP434_05510	COG2329	Antibiotic biosynthesis monooxygenase
NP434_05515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP434_05520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NP434_05525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NP434_05530	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NP434_05535	COG1309	transcriptional regulator
NP434_05540	COG1511	domain protein
NP434_05545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP434_05550	COG4377	Putative membrane peptidase family (DUF2324)
NP434_05560	COG1363	Peptidase, m42
NP434_05565	COG4405	Protein conserved in bacteria
NP434_05570	COG1301	dicarboxylic acid transport
NP434_05580	COG1234	tRNA 3'-trailer cleavage
NP434_05585	COG0095	Lipoate-protein ligase
NP434_05590	COG0702	epimerase
NP434_05595	COG0318	PFAM AMP-dependent synthetase and ligase
NP434_05605	COG0501	Belongs to the peptidase M48B family
NP434_05615	COG0456	acetyltransferase
NP434_05620	COG0604	alcohol dehydrogenase
NP434_05625	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP434_05630	COG0406	alpha-ribazole phosphatase activity
NP434_05635	COG0183	Belongs to the thiolase family
NP434_05640	COG0318	PFAM AMP-dependent synthetase and ligase
NP434_05645	COG1268	BioY protein
NP434_05650	COG0840	transmembrane signaling receptor activity
NP434_05655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP434_05655	COG0723	plastoquinol--plastocyanin reductase activity
NP434_05660	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_05670	COG4903	ComK protein
NP434_05675	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_05685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP434_05700	COG0398	Pfam SNARE associated Golgi protein
NP434_05705	COG0681	Belongs to the peptidase S26 family
NP434_05710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP434_05715	COG1846	Transcriptional regulator
NP434_05720	COG0738	Major facilitator superfamily
NP434_05725	COG0673	inositol 2-dehydrogenase activity
NP434_05730	COG0561	phosphatase activity
NP434_05735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP434_05740	COG1609	Transcriptional regulator
NP434_05745	COG3180	Ammonia monooxygenase
NP434_05750	COG2814	Major facilitator Superfamily
NP434_05750	COG0477	Major facilitator Superfamily
NP434_05755	COG4533	DNA binding
NP434_05765	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NP434_05770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NP434_05775	COG1074	ATP-dependent DNA helicase activity
NP434_05780	COG0420	3'-5' exonuclease activity
NP434_05785	COG0419	ATPase involved in DNA repair
NP434_05790	COG1403	HNH endonuclease
NP434_05830	COG5337	Spore coat protein CotH
NP434_05835	COG0179	Fumarylacetoacetate (FAA) hydrolase
NP434_05845	COG1404	Belongs to the peptidase S8 family
NP434_05855	COG0367	asparagine synthase
NP434_05860	COG2318	DinB family
NP434_05865	COG1562	ergosterol biosynthetic process
NP434_05870	COG0534	Mate efflux family protein
NP434_05875	COG1917	Cupin 2, conserved barrel domain protein
NP434_05875	COG2207	Transcriptional regulator
NP434_05880	COG1609	Transcriptional regulator
NP434_05885	COG0673	inositol 2-dehydrogenase activity
NP434_05890	COG2318	DinB family
NP434_05895	COG1279	arginine transmembrane transporter activity
NP434_05900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP434_05905	COG1357	PFAM Pentapeptide repeats (8 copies)
NP434_05910	COG2267	carboxylic ester hydrolase activity
NP434_05915	COG0529	Catalyzes the synthesis of activated sulfate
NP434_05920	COG2046	Belongs to the sulfate adenylyltransferase family
NP434_05925	COG0175	sulfate reduction
NP434_05930	COG2045	Belongs to the ComB family
NP434_05935	COG1809	phosphosulfolactate synthase activity
NP434_05940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP434_05945	COG4948	Mandelate Racemase Muconate Lactonizing
NP434_05950	COG2814	Major facilitator Superfamily
NP434_05955	COG0454	-acetyltransferase
NP434_05960	COG2153	protein acetylation
NP434_05965	COG0646	methionine synthase
NP434_05965	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NP434_05970	COG1666	GTP binding
NP434_05995	COG1695	Transcriptional regulator
NP434_06010	COG3227	Zinc metalloprotease (Elastase)
NP434_06015	COG1307	EDD domain protein, DegV family
NP434_06020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP434_06040	COG0561	phosphatase activity
NP434_06045	COG1073	alpha beta
NP434_06050	COG2151	metal-sulfur cluster biosynthetic enzyme
NP434_06060	COG0277	FAD linked oxidase domain protein
NP434_06065	COG2271	Major facilitator Superfamily
NP434_06070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NP434_06075	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NP434_06085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP434_06090	COG0505	Belongs to the CarA family
NP434_06095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP434_06100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NP434_06115	COG2267	carboxylic ester hydrolase activity
NP434_06125	COG1744	ABC transporter substrate-binding protein PnrA-like
NP434_06140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP434_06145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP434_06150	COG5504	Zn-dependent protease
NP434_06155	COG0444	Belongs to the ABC transporter superfamily
NP434_06160	COG4608	Belongs to the ABC transporter superfamily
NP434_06170	COG0601	transmembrane transport
NP434_06175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP434_06185	COG0180	Tryptophanyl-tRNA synthetase
NP434_06190	COG4166	transmembrane transport
NP434_06195	COG0601	transmembrane transport
NP434_06200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP434_06205	COG0444	Belongs to the ABC transporter superfamily
NP434_06210	COG4608	Belongs to the ABC transporter superfamily
NP434_06215	COG2814	Major facilitator Superfamily
NP434_06220	COG0456	acetyltransferase
NP434_06225	COG1393	Belongs to the ArsC family
NP434_06230	COG0861	Integral membrane protein TerC family
NP434_06240	COG4862	establishment of competence for transformation
NP434_06250	COG4469	Competence protein
NP434_06255	COG1164	Oligoendopeptidase f
NP434_06265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP434_06270	COG2346	COG2346, Truncated hemoglobins
NP434_06275	COG0741	lytic transglycosylase activity
NP434_06280	COG4116	CYTH
NP434_06290	COG2357	RelA SpoT domain protein
NP434_06295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP434_06300	COG0564	pseudouridine synthase activity
NP434_06305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NP434_06310	COG0475	glutathione-regulated potassium exporter activity
NP434_06310	COG0569	domain protein
NP434_06315	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NP434_06320	COG0352	thiamine-phosphate diphosphorylase activity
NP434_06325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP434_06330	COG2104	thiamine diphosphate biosynthetic process
NP434_06335	COG2022	thiamine diphosphate biosynthetic process
NP434_06340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP434_06345	COG0351	phosphomethylpyrimidine kinase
NP434_06350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NP434_06405	COG0210	DNA helicase
NP434_06415	COG2153	protein acetylation
NP434_06420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP434_06425	COG2382	esterase
NP434_06430	COG0626	cystathionine gamma-synthase activity
NP434_06435	COG0626	cystathionine gamma-synthase activity
NP434_06440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP434_06445	COG5505	Protein of unknown function (DUF819)
NP434_06480	COG5444	nuclease activity
NP434_06500	COG0457	Tetratricopeptide repeat
NP434_06505	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NP434_06510	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_06520	COG3711	transcriptional antiterminator
NP434_06520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP434_06525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP434_06525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP434_06525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP434_06530	COG1482	cell wall glycoprotein biosynthetic process
NP434_06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP434_06550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NP434_06565	COG0109	protoheme IX farnesyltransferase activity
NP434_06575	COG0726	polysaccharide deacetylase
NP434_06590	COG5504	Zn-dependent protease
NP434_06595	COG2205	protein histidine kinase activity
NP434_06605	COG3383	formate dehydrogenase (NAD+) activity
NP434_06610	COG2427	Protein of unknown function (DUF1641)
NP434_06620	COG1051	belongs to the nudix hydrolase family
NP434_06630	COG2124	cytochrome p450
NP434_06635	COG1819	glycosyl
NP434_06645	COG1587	Uroporphyrinogen-III synthase
NP434_06650	COG0390	transport system, permease component
NP434_06655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP434_06660	COG0697	spore germination
NP434_06665	COG4297	protein containing double-stranded beta helix domain
NP434_06675	COG1252	NADH dehydrogenase
NP434_06680	COG1904	glucuronate isomerase
NP434_06685	COG2211	Major facilitator Superfamily
NP434_06690	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NP434_06695	COG1063	alcohol dehydrogenase
NP434_06700	COG1312	Catalyzes the dehydration of D-mannonate
NP434_06705	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_06710	COG2271	Major facilitator Superfamily
NP434_06715	COG1609	Transcriptional regulator
NP434_06720	COG0246	Mannitol dehydrogenase
NP434_06725	COG2721	sulfolactate sulfo-lyase activity
NP434_06730	COG0730	response to heat
NP434_06735	COG2318	DinB family
NP434_06740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP434_06745	COG0457	Tetratricopeptide repeat
NP434_06755	COG2350	Protein conserved in bacteria
NP434_06760	COG3409	Peptidoglycan-binding domain 1 protein
NP434_06760	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP434_06760	COG1388	LysM domain
NP434_06770	COG4195	phage-related replication protein
NP434_06780	COG2856	Zn peptidase
NP434_06785	COG1396	sequence-specific DNA binding
NP434_06795	COG1522	sequence-specific DNA binding
NP434_06800	COG1484	DNA-dependent DNA replication
NP434_06820	COG1595	DNA-templated transcription, initiation
NP434_06825	COG3728	DNA packaging
NP434_06825	COG5484	DNA packaging
NP434_06830	COG1783	phage Terminase large subunit
NP434_06835	COG5518	Phage portal protein
NP434_06840	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NP434_06845	COG4653	Phage capsid family
NP434_06895	COG5412	phage tail tape measure protein
NP434_06895	COG3953	SLT domain
NP434_06900	COG1652	LysM domain
NP434_06905	COG4193	domain, Protein
NP434_06915	COG3628	GPW Gp25 family protein
NP434_06920	COG3299	homolog of phage Mu protein gp47
NP434_06925	COG3778	Protein conserved in bacteria
NP434_06965	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP434_06965	COG3409	Peptidoglycan-binding domain 1 protein
NP434_06970	COG3594	Acyltransferase
NP434_06990	COG0306	phosphate transporter
NP434_06995	COG1392	Phosphate transport regulator
NP434_07000	COG0531	amino acid
NP434_07005	COG0346	lactoylglutathione lyase activity
NP434_07015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP434_07020	COG0463	Glycosyl transferase, family 2
NP434_07030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP434_07035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP434_07040	COG2362	D-Aminopeptidase
NP434_07045	COG0601	transmembrane transport
NP434_07050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP434_07055	COG0444	Belongs to the ABC transporter superfamily
NP434_07060	COG4166	transmembrane transport
NP434_07065	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP434_07070	COG4948	Mandelate Racemase Muconate Lactonizing
NP434_07075	COG0791	NLP P60 protein
NP434_07080	COG4608	Belongs to the ABC transporter superfamily
NP434_07085	COG2706	6-phosphogluconolactonase activity
NP434_07090	COG1834	amidinotransferase
NP434_07095	COG1607	acyl-coa hydrolase
NP434_07100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP434_07100	COG1017	nitric oxide dioxygenase activity
NP434_07110	COG2323	membrane
NP434_07115	COG2318	DinB family
NP434_07120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP434_07125	COG2076	Multidrug Resistance protein
NP434_07130	COG2076	Multidrug Resistance protein
NP434_07135	COG0788	formyltetrahydrofolate deformylase activity
NP434_07140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP434_07145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NP434_07150	COG1764	response to oxidative stress
NP434_07155	COG1846	Transcriptional regulator
NP434_07160	COG1764	response to oxidative stress
NP434_07170	COG0590	tRNA wobble adenosine to inosine editing
NP434_07175	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP434_07180	COG1404	Belongs to the peptidase S8 family
NP434_07185	COG1366	Belongs to the anti-sigma-factor antagonist family
NP434_07190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP434_07195	COG1122	ATPase activity
NP434_07200	COG4721	ABC-type cobalt transport system, permease component
NP434_07210	COG0745	RESPONSE REGULATOR receiver
NP434_07215	COG3850	Histidine kinase
NP434_07215	COG5002	protein histidine kinase activity
NP434_07220	COG3212	peptidase
NP434_07225	COG3212	peptidase
NP434_07240	COG2239	Acts as a magnesium transporter
NP434_07245	COG0789	Transcriptional regulator
NP434_07260	COG1846	Transcriptional regulator
NP434_07265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP434_07270	COG0726	polysaccharide deacetylase
NP434_07275	COG1408	metallophosphoesterase
NP434_07285	COG0463	Glycosyl transferase, family 2
NP434_07290	COG3285	dna ligase
NP434_07290	COG1793	dna ligase
NP434_07295	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NP434_07300	COG5001	Diguanylate cyclase
NP434_07300	COG3300	MHYT domain
NP434_07305	COG0586	Pfam SNARE associated Golgi protein
NP434_07310	COG0861	Integral membrane protein TerC family
NP434_07315	COG1191	sigma factor activity
NP434_07335	COG0501	Belongs to the peptidase M48B family
NP434_07340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP434_07355	COG3594	Acyltransferase
NP434_07360	COG5002	protein histidine kinase activity
NP434_07365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP434_07375	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NP434_07380	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NP434_07385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP434_07390	COG0436	Aminotransferase
NP434_07395	COG1850	ribulose-bisphosphate carboxylase activity
NP434_07400	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NP434_07405	COG0235	Class ii aldolase
NP434_07410	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NP434_07415	COG3339	Conserved Protein
NP434_07430	COG3852	Histidine kinase
NP434_07435	COG1846	Transcriptional regulator
NP434_07440	COG1360	Flagellar Motor Protein
NP434_07445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP434_07450	COG0542	response to heat
NP434_07455	COG3949	Membrane
NP434_07460	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NP434_07465	COG0720	synthase
NP434_07470	COG0602	queuosine metabolic process
NP434_07475	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NP434_07480	COG1733	regulation of RNA biosynthetic process
NP434_07485	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_07490	COG4641	Protein conserved in bacteria
NP434_07490	COG1388	LysM domain
NP434_07495	COG1388	LysM domain
NP434_07500	COG3858	chitin binding
NP434_07510	COG4873	Protein conserved in bacteria
NP434_07520	COG3773	Cell wall hydrolase
NP434_07525	COG2244	polysaccharide biosynthetic process
NP434_07530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP434_07535	COG2217	Heavy metal translocating P-type atpase
NP434_07545	COG0006	proline dipeptidase activity
NP434_07550	COG1609	Transcriptional regulator
NP434_07555	COG3711	transcriptional antiterminator
NP434_07560	COG1263	PTS System
NP434_07560	COG2190	(PTS) system
NP434_07560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_07565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP434_07570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP434_07580	COG1533	DNA photolyase activity
NP434_07585	COG0456	acetyltransferase
NP434_07590	COG0840	transmembrane signaling receptor activity
NP434_07595	COG2084	Dehydrogenase
NP434_07600	COG2340	Cysteine-rich secretory protein family
NP434_07605	COG0768	penicillin binding
NP434_07610	COG4191	Histidine kinase
NP434_07615	COG0436	Aminotransferase
NP434_07625	COG0784	Response regulator, receiver
NP434_07625	COG0835	chemotaxis
NP434_07635	COG2814	Major facilitator Superfamily
NP434_07640	COG1376	ErfK ybiS ycfS ynhG family protein
NP434_07645	COG1408	metallophosphoesterase
NP434_07650	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_07655	COG2200	EAL domain
NP434_07660	COG4703	Protein of unknown function (DUF1797)
NP434_07665	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NP434_07675	COG0517	IMP dehydrogenase activity
NP434_07680	COG0583	DNA-binding transcription factor activity
NP434_07685	COG0716	FMN binding
NP434_07695	COG0716	FMN binding
NP434_07700	COG2171	N-acyltransferase activity
NP434_07705	COG1473	amidohydrolase
NP434_07715	COG0668	transmembrane transport
NP434_07720	COG0450	alkyl hydroperoxide reductase
NP434_07725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP434_07740	COG0746	molybdenum cofactor guanylyltransferase activity
NP434_07745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP434_07750	COG0303	'Molybdopterin
NP434_07755	COG1763	Mo-molybdopterin cofactor biosynthetic process
NP434_07760	COG0314	molybdopterin synthase activity
NP434_07765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NP434_07770	COG1132	(ABC) transporter
NP434_07775	COG1132	(ABC) transporter
NP434_07785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP434_07790	COG1136	(ABC) transporter
NP434_07795	COG0577	efflux transmembrane transporter activity
NP434_07800	COG1349	DNA-binding transcription factor activity
NP434_07805	COG1105	Belongs to the carbohydrate kinase PfkB family
NP434_07810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP434_07810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP434_07810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP434_07815	COG0681	Belongs to the peptidase S26 family
NP434_07825	COG0488	(ABC) transporter
NP434_07830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP434_07835	COG2309	aminopeptidase activity
NP434_07845	COG1077	Cell shape determining protein MreB Mrl
NP434_07850	COG2002	toxin-antitoxin pair type II binding
NP434_07855	COG3852	Histidine kinase
NP434_07860	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NP434_07860	COG2105	PFAM AIG2 family protein
NP434_07865	COG0569	domain protein
NP434_07870	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP434_07875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP434_07880	COG5503	Protein of unknown function (DUF1447)
NP434_07885	COG0561	phosphatase activity
NP434_07890	COG0242	peptide deformylase activity
NP434_07900	COG0497	DNA recombination
NP434_07905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP434_07910	COG0022	dehydrogenase e1 component
NP434_07915	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP434_07920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP434_07925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP434_07935	COG1982	Orn Lys Arg decarboxylase major
NP434_07940	COG4476	Belongs to the UPF0223 family
NP434_07945	COG4493	Belongs to the UPF0637 family
NP434_07955	COG0483	inositol monophosphate 1-phosphatase activity
NP434_07965	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NP434_08005	COG1217	gtp-binding protein TYPA
NP434_08015	COG4896	Protein conserved in bacteria
NP434_08025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NP434_08030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP434_08035	COG2066	Belongs to the glutaminase family
NP434_08040	COG4838	Belongs to the UPF0358 family
NP434_08045	COG0772	Belongs to the SEDS family
NP434_08050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NP434_08055	COG1612	heme a metabolic process
NP434_08060	COG0109	protoheme IX farnesyltransferase activity
NP434_08065	COG2010	Cytochrome c
NP434_08065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP434_08070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP434_08075	COG1845	cytochrome c oxidase, subunit III
NP434_08080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP434_08085	COG3336	cytochrome c oxidase
NP434_08095	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NP434_08100	COG2340	Cysteine-rich secretory protein family
NP434_08115	COG3679	Belongs to the UPF0342 family
NP434_08120	COG4471	UPF0298 protein
NP434_08125	COG0742	ribosomal rna small subunit methyltransferase
NP434_08130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NP434_08135	COG3314	Sporulation integral membrane protein YlbJ
NP434_08140	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP434_08145	COG3480	Lon protease (S16) C-terminal proteolytic domain
NP434_08165	COG1399	metal-binding, possibly nucleic acid-binding protein
NP434_08180	COG0454	-acetyltransferase
NP434_08185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP434_08190	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NP434_08195	COG2001	Belongs to the MraZ family
NP434_08200	COG0275	rRNA processing
NP434_08205	COG4839	cell division protein FtsL
NP434_08210	COG0768	penicillin binding
NP434_08215	COG0768	penicillin binding
NP434_08220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NP434_08225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP434_08230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP434_08235	COG0772	Belongs to the SEDS family
NP434_08240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP434_08245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NP434_08250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NP434_08255	COG3879	Bacterial protein of unknown function (DUF881)
NP434_08260	COG3879	Bacterial protein of unknown function (DUF881)
NP434_08265	COG3856	small basic protein
NP434_08270	COG0849	cell division
NP434_08275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NP434_08295	COG4412	M6 family metalloprotease domain protein
NP434_08295	COG1404	Belongs to the peptidase S8 family
NP434_08305	COG1191	sigma factor activity
NP434_08310	COG1191	sigma factor activity
NP434_08315	COG1119	ATPase activity
NP434_08320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP434_08325	COG1873	PFAM PRC-barrel domain
NP434_08330	COG1496	oxidoreductase activity
NP434_08335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NP434_08340	COG1799	cell septum assembly
NP434_08345	COG0762	integral membrane protein
NP434_08350	COG2302	S4 RNA-binding domain
NP434_08355	COG3599	regulation of cell shape
NP434_08360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NP434_08365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP434_08370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NP434_08375	COG0564	pseudouridine synthase activity
NP434_08380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NP434_08385	COG2233	PERMEase
NP434_08390	COG0540	Belongs to the ATCase OTCase family
NP434_08395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP434_08400	COG0505	Belongs to the CarA family
NP434_08405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP434_08410	COG0543	2 iron, 2 sulfur cluster binding
NP434_08415	COG0167	dihydroorotate dehydrogenase activity
NP434_08420	COG0284	orotidine-5'-phosphate decarboxylase activity
NP434_08425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NP434_08430	COG0175	sulfate reduction
NP434_08435	COG0306	phosphate transporter
NP434_08440	COG2046	Belongs to the sulfate adenylyltransferase family
NP434_08445	COG0529	Catalyzes the synthesis of activated sulfate
NP434_08450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP434_08455	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NP434_08460	COG1648	precorrin-2 dehydrogenase activity
NP434_08465	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NP434_08470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP434_08475	COG1561	YicC-like family, N-terminal region
NP434_08485	COG0194	GDP metabolic process
NP434_08490	COG1758	RNA polymerase activity
NP434_08495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP434_08500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP434_08505	COG0242	peptide deformylase activity
NP434_08510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NP434_08515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NP434_08515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP434_08520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NP434_08525	COG0631	protein serine/threonine phosphatase activity
NP434_08530	COG0515	serine threonine protein kinase
NP434_08530	COG2815	serine threonine protein kinase
NP434_08535	COG1162	GTPase activity
NP434_08540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NP434_08545	COG1564	THIamine pyrophosphokinase
NP434_08555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NP434_08560	COG1302	Protein conserved in bacteria
NP434_08565	COG1461	Dihydroxyacetone kinase
NP434_08570	COG1760	l-serine dehydratase
NP434_08575	COG1760	l-serine dehydratase
NP434_08580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NP434_08585	COG1349	DNA-binding transcription factor activity
NP434_08585	COG2050	protein possibly involved in aromatic compounds catabolism
NP434_08590	COG0416	fatty acid biosynthetic process
NP434_08595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP434_08600	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_08610	COG0571	ribonuclease III activity
NP434_08615	COG1196	nuclear chromosome segregation
NP434_08620	COG0552	protein localization to endoplasmic reticulum
NP434_08630	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NP434_08635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NP434_08640	COG0228	four-way junction DNA binding
NP434_08645	COG1837	Belongs to the UPF0109 family
NP434_08655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NP434_08660	COG0336	Belongs to the RNA methyltransferase TrmD family
NP434_08665	COG0335	large ribosomal subunit rRNA binding
NP434_08670	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP434_08675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP434_08685	COG2257	FlhB HrpN YscU SpaS Family
NP434_08690	COG0045	succinate-CoA ligase (ADP-forming) activity
NP434_08695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NP434_08700	COG0758	DNA mediated transformation
NP434_08705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP434_08710	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NP434_08715	COG4974	Belongs to the 'phage' integrase family
NP434_08720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NP434_08725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NP434_08730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP434_08735	COG1815	bacterial-type flagellum-dependent cell motility
NP434_08740	COG1558	bacterial-type flagellum-dependent cell motility
NP434_08745	COG1677	Flagellar hook-basal body complex protein FliE
NP434_08750	COG1766	The M ring may be actively involved in energy transduction
NP434_08755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP434_08760	COG1317	bacterial-type flagellum organization
NP434_08765	COG1157	protein secretion by the type III secretion system
NP434_08770	COG2882	bacterial-type flagellum organization
NP434_08775	COG3334	PFAM MgtE intracellular
NP434_08780	COG3144	bacterial-type flagellum assembly
NP434_08785	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NP434_08790	COG4786	Flagellar basal body rod
NP434_08795	COG1582	Flagellar protein (FlbD)
NP434_08800	COG1580	Controls the rotational direction of flagella during chemotaxis
NP434_08805	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP434_08810	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP434_08810	COG1776	CheC inhibitor of MCP methylation
NP434_08815	COG2201	protein-glutamate methylesterase activity
NP434_08820	COG3190	flagellar
NP434_08825	COG1338	Plays a role in the flagellum-specific transport system
NP434_08830	COG1987	bacterial-type flagellum assembly
NP434_08835	COG1684	flagellar biosynthetic protein fliR
NP434_08840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP434_08845	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP434_08850	COG1419	protein localization to endoplasmic reticulum
NP434_08855	COG0455	bacterial-type flagellum organization
NP434_08860	COG2201	protein-glutamate methylesterase activity
NP434_08865	COG2198	Histidine kinase
NP434_08865	COG0643	Histidine kinase
NP434_08870	COG0835	chemotaxis
NP434_08875	COG1776	CheC inhibitor of MCP methylation
NP434_08880	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NP434_08885	COG1191	sigma factor activity
NP434_08895	COG0052	Belongs to the universal ribosomal protein uS2 family
NP434_08900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NP434_08905	COG0528	UMP kinase activity
NP434_08910	COG0233	cytoplasmic translational termination
NP434_08915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NP434_08920	COG4589	Belongs to the CDS family
NP434_08925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NP434_08930	COG0750	zinc metalloprotease
NP434_08935	COG0442	prolyl-tRNA aminoacylation
NP434_08940	COG2176	DNA-directed DNA polymerase activity
NP434_08945	COG0779	Required for maturation of 30S ribosomal subunits
NP434_08950	COG0195	Participates in both transcription termination and antitermination
NP434_08955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NP434_08960	COG1358	cellular component organization or biogenesis
NP434_08965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NP434_08970	COG1550	Protein conserved in bacteria
NP434_08975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NP434_08980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NP434_08985	COG0196	riboflavin kinase activity
NP434_08990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NP434_08995	COG1185	polyribonucleotide nucleotidyltransferase activity
NP434_09000	COG0726	polysaccharide deacetylase
NP434_09005	COG0612	Peptidase, M16
NP434_09010	COG1873	PFAM PRC-barrel domain
NP434_09015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP434_09020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP434_09025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NP434_09030	COG0527	aspartate kinase activity
NP434_09035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP434_09040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP434_09045	COG0740	serine-type endopeptidase activity
NP434_09055	COG1674	ftsk spoiiie
NP434_09055	COG4980	gas vesicle protein
NP434_09060	COG2188	Transcriptional regulator
NP434_09065	COG2814	Major facilitator Superfamily
NP434_09070	COG0612	Peptidase, M16
NP434_09075	COG0612	Peptidase, M16
NP434_09080	COG0300	oxidoreductase activity
NP434_09095	COG1426	Protein conserved in bacteria
NP434_09100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NP434_09105	COG1546	Belongs to the CinA family
NP434_09105	COG1058	Belongs to the CinA family
NP434_09110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NP434_09115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP434_09120	COG1418	mRNA catabolic process
NP434_09125	COG1692	metallophosphoesterase
NP434_09130	COG2359	stage V sporulation protein S
NP434_09135	COG1063	alcohol dehydrogenase
NP434_09140	COG0156	8-amino-7-oxononanoate synthase activity
NP434_09145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP434_09150	COG4550	Control of competence regulator ComK, YlbF/YmcA
NP434_09160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NP434_09165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NP434_09180	COG3226	Transcriptional regulator
NP434_09185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP434_09195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP434_09200	COG3321	synthase
NP434_09205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP434_09205	COG2070	2-Nitropropane dioxygenase
NP434_09210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP434_09215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP434_09220	COG3425	synthase
NP434_09225	COG1024	Enoyl-CoA hydratase
NP434_09230	COG1024	Enoyl-CoA hydratase
NP434_09235	COG0300	oxidoreductase activity
NP434_09235	COG0318	PFAM AMP-dependent synthetase and ligase
NP434_09235	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_09235	COG3321	synthase
NP434_09235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_09240	COG4221	oxidoreductase activity
NP434_09240	COG3321	synthase
NP434_09240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP434_09240	COG0300	oxidoreductase activity
NP434_09245	COG3321	synthase
NP434_09245	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_09245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_09245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP434_09245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP434_09250	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_09250	COG3321	synthase
NP434_09250	COG4221	oxidoreductase activity
NP434_09250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_09255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP434_09255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP434_09255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NP434_09255	COG3321	synthase
NP434_09260	COG2124	cytochrome p450
NP434_09270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP434_09275	COG1404	Belongs to the peptidase S8 family
NP434_09285	COG4195	phage-related replication protein
NP434_09290	COG1764	response to oxidative stress
NP434_09295	COG2076	Multidrug Resistance protein
NP434_09300	COG2076	Multidrug Resistance protein
NP434_09315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NP434_09320	COG1923	regulation of RNA biosynthetic process
NP434_09335	COG1780	Probably involved in ribonucleotide reductase function
NP434_09340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP434_09345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP434_09350	COG4112	unkown
NP434_09355	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP434_09360	COG0464	growth
NP434_09365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NP434_09370	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NP434_09375	COG0789	Transcriptional regulator
NP434_09380	COG0174	glutamine synthetase
NP434_09400	COG4282	regulation of fungal-type cell wall biogenesis
NP434_09415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP434_09430	COG3655	Transcriptional regulator
NP434_09455	COG0135	phosphoribosylanthranilate isomerase activity
NP434_09460	COG2211	Major facilitator Superfamily
NP434_09465	COG3507	Belongs to the glycosyl hydrolase 43 family
NP434_09470	COG1940	carbohydrate kinase activity
NP434_09475	COG2115	Belongs to the xylose isomerase family
NP434_09480	COG1070	Carbohydrate kinase
NP434_09490	COG1525	nuclease
NP434_09500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP434_09510	COG0756	dUTP diphosphatase activity
NP434_09545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP434_09560	COG3832	glyoxalase III activity
NP434_09575	COG0697	spore germination
NP434_09580	COG0531	amino acid
NP434_09610	COG4195	phage-related replication protein
NP434_09630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NP434_09635	COG1388	LysM domain
NP434_09640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP434_09645	COG4224	UPF0291 protein
NP434_09650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NP434_09660	COG3763	UPF0154 protein
NP434_09670	COG0785	Cytochrome C biogenesis protein
NP434_09675	COG2201	protein-glutamate methylesterase activity
NP434_09680	COG4846	Membrane protein involved in cytochrome C biogenesis
NP434_09690	COG0071	Belongs to the small heat shock protein (HSP20) family
NP434_09705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NP434_09710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP434_09730	COG0824	Thioesterase
NP434_09740	COG4841	protein insertion into membrane
NP434_09745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NP434_09750	COG1832	CoA-binding protein
NP434_09755	COG0187	DNA topoisomerase II activity
NP434_09760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP434_09775	COG1115	amino acid carrier protein
NP434_09790	COG5520	Belongs to the glycosyl hydrolase 30 family
NP434_09795	COG3507	Belongs to the glycosyl hydrolase 43 family
NP434_09800	COG2246	polysaccharide biosynthetic process
NP434_09805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP434_09810	COG0586	Pfam SNARE associated Golgi protein
NP434_09815	COG2404	hydrolase activity, acting on ester bonds
NP434_09820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP434_09825	COG1024	Enoyl-CoA hydratase
NP434_09830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP434_09835	COG0511	ligase activity, forming carbon-carbon bonds
NP434_09840	COG0439	Biotin carboxylase
NP434_09845	COG0318	PFAM AMP-dependent synthetase and ligase
NP434_09850	COG1960	acyl-CoA dehydrogenase activity
NP434_09865	COG1649	PFAM Uncharacterised BCR, COG1649
NP434_09875	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NP434_09875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_09880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_09885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_09890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_09895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_09900	COG2027	D-alanyl-D-alanine carboxypeptidase
NP434_09905	COG2017	converts alpha-aldose to the beta-anomer
NP434_09910	COG0534	Mate efflux family protein
NP434_09925	COG0582	viral genome integration into host DNA
NP434_09930	COG0166	Belongs to the GPI family
NP434_09935	COG0405	Gamma-glutamyltransferase
NP434_09940	COG0583	DNA-binding transcription factor activity
NP434_09945	COG0604	alcohol dehydrogenase
NP434_09950	COG0493	'glutamate synthase
NP434_09955	COG0069	glutamate synthase activity
NP434_09955	COG0070	glutamate synthase
NP434_09955	COG0067	glutamate synthase
NP434_09960	COG0583	DNA-binding transcription factor activity
NP434_09965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP434_09970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP434_09980	COG0300	oxidoreductase activity
NP434_09985	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NP434_09995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP434_10015	COG2814	Major facilitator Superfamily
NP434_10020	COG1070	Carbohydrate kinase
NP434_10025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP434_10030	COG0243	molybdopterin cofactor binding
NP434_10060	COG0840	transmembrane signaling receptor activity
NP434_10060	COG5278	phosphoserine phosphatase activity
NP434_10065	COG2368	4-hydroxyphenylacetate
NP434_10070	COG4305	rare lipoprotein A
NP434_10075	COG3619	membrane
NP434_10080	COG3866	Pectate lyase
NP434_10085	COG2135	peptidase activity
NP434_10095	COG2140	Oxalate decarboxylase
NP434_10110	COG0456	acetyltransferase
NP434_10130	COG2720	vancomycin resistance protein
NP434_10145	COG3739	integral membrane protein
NP434_10150	COG0583	DNA-binding transcription factor activity
NP434_10155	COG0697	spore germination
NP434_10165	COG0693	protein deglycase activity
NP434_10170	COG2367	Beta-lactamase
NP434_10190	COG3848	Pyruvate phosphate dikinase
NP434_10190	COG0574	Belongs to the PEP-utilizing enzyme family
NP434_10195	COG0726	polysaccharide deacetylase
NP434_10200	COG2314	TM2 domain
NP434_10250	COG2723	6-phospho-beta-galactosidase activity
NP434_10265	COG0395	ABC-type sugar transport system, permease component
NP434_10270	COG1175	transmembrane transport
NP434_10280	COG1940	carbohydrate kinase activity
NP434_10295	COG5444	nuclease activity
NP434_10300	COG4282	regulation of fungal-type cell wall biogenesis
NP434_10305	COG1231	oxidoreductase activity
NP434_10310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP434_10315	COG2207	Transcriptional regulator
NP434_10315	COG0662	Cupin 2, conserved barrel domain protein
NP434_10320	COG0456	acetyltransferase
NP434_10325	COG1309	transcriptional regulator
NP434_10330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP434_10335	COG3708	Transcriptional regulator
NP434_10340	COG2378	regulation of single-species biofilm formation
NP434_10350	COG0640	Transcriptional regulator
NP434_10355	COG0741	lytic transglycosylase activity
NP434_10360	COG2322	membrane
NP434_10375	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP434_10380	COG3239	Fatty acid desaturase
NP434_10385	COG4585	Histidine kinase
NP434_10390	COG2197	response regulator
NP434_10395	COG3584	3D domain protein
NP434_10395	COG1388	LysM domain
NP434_10400	COG0514	ATP-dependent DNA helicase (RecQ)
NP434_10410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP434_10415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP434_10430	COG0071	Belongs to the small heat shock protein (HSP20) family
NP434_10455	COG1012	belongs to the aldehyde dehydrogenase family
NP434_10460	COG1657	PFAM Prenyltransferase squalene oxidase
NP434_10465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP434_10470	COG0733	neurotransmitter:sodium symporter activity
NP434_10475	COG0385	Bile acid
NP434_10480	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP434_10485	COG0567	Dehydrogenase, E1 component
NP434_10490	COG4548	von Willebrand factor, type A
NP434_10495	COG0714	Associated with various cellular activities
NP434_10500	COG2032	superoxide dismutase activity
NP434_10505	COG1388	LysM domain
NP434_10505	COG0791	NLP P60 protein
NP434_10510	COG1819	glycosyl
NP434_10515	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP434_10520	COG0534	Mate efflux family protein
NP434_10525	COG1366	Belongs to the anti-sigma-factor antagonist family
NP434_10530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP434_10535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP434_10545	COG2962	Rard protein
NP434_10560	COG2610	gluconate transmembrane transporter activity
NP434_10565	COG1942	4-Oxalocrotonate Tautomerase
NP434_10570	COG1733	regulation of RNA biosynthetic process
NP434_10575	COG0778	Nitroreductase
NP434_10580	COG0400	carboxylic ester hydrolase activity
NP434_10585	COG0346	lactoylglutathione lyase activity
NP434_10595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP434_10600	COG0793	Belongs to the peptidase S41A family
NP434_10600	COG3409	Peptidoglycan-binding domain 1 protein
NP434_10605	COG2226	methyltransferase
NP434_10615	COG1876	peptidase activity
NP434_10620	COG0813	purine-nucleoside phosphorylase activity
NP434_10635	COG0671	phosphoesterase, PA-phosphatase related
NP434_10655	COG4479	Belongs to the UPF0346 family
NP434_10665	COG1509	lysine 2,3-aminomutase activity
NP434_10670	COG0456	acetyltransferase
NP434_10675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP434_10680	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP434_10685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP434_10690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP434_10705	COG0456	acetyltransferase
NP434_10710	COG0463	Glycosyl transferase, family 2
NP434_10725	COG4641	Protein conserved in bacteria
NP434_10730	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
NP434_10735	COG1086	Polysaccharide biosynthesis protein
NP434_10740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP434_10745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP434_10750	COG1846	Transcriptional regulator
NP434_10755	COG0534	Mate efflux family protein
NP434_10765	COG4698	Protein conserved in bacteria
NP434_10770	COG2755	lipolytic protein G-D-S-L family
NP434_10775	COG1999	signal sequence binding
NP434_10785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NP434_10790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP434_10795	COG1272	protein, Hemolysin III
NP434_10800	COG0204	Acyl-transferase
NP434_10805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP434_10810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NP434_10815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP434_10825	COG2521	methyltransferase
NP434_10825	COG2136	Putative SAM-dependent methyltransferase
NP434_10835	COG0129	dihydroxy-acid dehydratase activity
NP434_10840	COG1413	lyase activity
NP434_10845	COG1418	mRNA catabolic process
NP434_10850	COG0386	Belongs to the glutathione peroxidase family
NP434_10855	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NP434_10860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP434_10870	COG1278	Cold shock
NP434_10890	COG0328	RNA-DNA hybrid ribonuclease activity
NP434_10895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NP434_10900	COG0328	RNA-DNA hybrid ribonuclease activity
NP434_10910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP434_10925	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP434_10935	COG1755	Isoprenylcysteine carboxyl methyltransferase
NP434_10940	COG3424	synthase
NP434_10945	COG2233	PERMEase
NP434_10950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP434_10955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NP434_10965	COG0800	Aldolase
NP434_10970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP434_10975	COG1609	Transcriptional regulator
NP434_10980	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NP434_10985	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_10990	COG1199	ATP-dependent helicase activity
NP434_11005	COG0116	Belongs to the methyltransferase superfamily
NP434_11020	COG4474	Belongs to the UPF0398 family
NP434_11035	COG3359	exonuclease
NP434_11040	COG1205	dead DEAH box helicase
NP434_11040	COG1111	helicase
NP434_11045	COG2190	(PTS) system
NP434_11050	COG0071	Belongs to the small heat shock protein (HSP20) family
NP434_11085	COG3331	DNA recombination
NP434_11090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP434_11090	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP434_11100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NP434_11105	COG3935	DnaD domain protein
NP434_11110	COG0017	Asparaginyl-tRNA synthetase
NP434_11115	COG0436	Aminotransferase
NP434_11120	COG5353	protein conserved in bacteria
NP434_11130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NP434_11130	COG1199	ATP-dependent helicase activity
NP434_11135	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NP434_11140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NP434_11145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NP434_11150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NP434_11150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NP434_11155	COG0617	tRNA 3'-terminal CCA addition
NP434_11160	COG0438	transferase activity, transferring glycosyl groups
NP434_11165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP434_11170	COG1803	Methylglyoxal synthase
NP434_11175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NP434_11180	COG1694	Mazg nucleotide pyrophosphohydrolase
NP434_11185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP434_11195	COG4347	Protein of unknown function (DUF1405)
NP434_11200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP434_11200	COG2010	Cytochrome c
NP434_11205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP434_11210	COG0723	plastoquinol--plastocyanin reductase activity
NP434_11220	COG5582	Belongs to the UPF0302 family
NP434_11225	COG0457	Tetratricopeptide repeat
NP434_11230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NP434_11235	COG0287	Prephenate dehydrogenase
NP434_11240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NP434_11245	COG0159	tryptophan synthase activity
NP434_11250	COG0133	tryptophan synthase activity
NP434_11255	COG0135	phosphoribosylanthranilate isomerase activity
NP434_11265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NP434_11270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP434_11275	COG4401	Chorismate mutase type I
NP434_11280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NP434_11285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NP434_11290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NP434_11295	COG0105	UTP biosynthetic process
NP434_11300	COG0142	geranyltranstransferase activity
NP434_11305	COG2226	methyltransferase
NP434_11310	COG0142	geranyltranstransferase activity
NP434_11320	COG0302	gtp cyclohydrolase
NP434_11325	COG0776	regulation of translation
NP434_11330	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP434_11345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NP434_11350	COG1160	GTP binding
NP434_11375	COG1304	FMN binding
NP434_11380	COG0539	negative regulation of cytoplasmic translation
NP434_11385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NP434_11395	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NP434_11400	COG2959	enzyme of heme biosynthesis
NP434_11405	COG3773	Cell wall hydrolase
NP434_11405	COG3409	Peptidoglycan-binding domain 1 protein
NP434_11410	COG2339	peptidase activity
NP434_11415	COG0492	ferredoxin-NADP+ reductase activity
NP434_11420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP434_11425	COG4862	establishment of competence for transformation
NP434_11430	COG1408	metallophosphoesterase
NP434_11440	COG1388	LysM domain
NP434_11445	COG1266	CAAX protease self-immunity
NP434_11450	COG0514	ATP-dependent DNA helicase (RecQ)
NP434_11455	COG4955	Helix-turn-helix domain
NP434_11460	COG1141	Ferredoxin
NP434_11465	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NP434_11470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP434_11475	COG0710	3-dehydroquinate dehydratase activity
NP434_11485	COG1595	DNA-templated transcription, initiation
NP434_11490	COG5002	protein histidine kinase activity
NP434_11495	COG0745	RESPONSE REGULATOR receiver
NP434_11500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP434_11505	COG1333	cytochrome c biogenesis protein
NP434_11510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP434_11515	COG1187	pseudouridine synthase activity
NP434_11520	COG0700	Nucleoside recognition
NP434_11525	COG2715	membrane protein required for spore maturation
NP434_11530	COG1686	Belongs to the peptidase S11 family
NP434_11540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NP434_11545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NP434_11550	COG1547	Domain of unknown function (DUF309)
NP434_11555	COG0456	acetyltransferase
NP434_11560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NP434_11565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP434_11565	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP434_11570	COG0307	riboflavin synthase, alpha
NP434_11575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP434_11575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP434_11585	COG0681	Belongs to the peptidase S26 family
NP434_11595	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
NP434_11615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP434_11620	COG4086	secreted protein
NP434_11625	COG0019	diaminopimelate decarboxylase activity
NP434_11630	COG0697	spore germination
NP434_11645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP434_11665	COG1191	sigma factor activity
NP434_11670	COG2172	sigma factor antagonist activity
NP434_11675	COG1366	Belongs to the anti-sigma-factor antagonist family
NP434_11680	COG1686	Belongs to the peptidase S11 family
NP434_11685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NP434_11690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NP434_11695	COG4974	Belongs to the 'phage' integrase family
NP434_11705	COG0735	belongs to the Fur family
NP434_11710	COG1300	Membrane
NP434_11720	COG0281	malic enzyme
NP434_11725	COG1757	Na H antiporter
NP434_11730	COG1027	Aspartate ammonia-lyase
NP434_11735	COG0252	asparaginase activity
NP434_11740	COG1396	sequence-specific DNA binding
NP434_11745	COG1379	DNA repair
NP434_11750	COG0494	nUDIX hydrolase
NP434_11760	COG0667	Aldo Keto reductase
NP434_11770	COG1073	alpha beta
NP434_11780	COG4918	Iron-sulphur cluster biosynthesis
NP434_11785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NP434_11785	COG0456	acetyltransferase
NP434_11790	COG2329	Antibiotic biosynthesis monooxygenase
NP434_11795	COG0456	acetyltransferase
NP434_11805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP434_11815	COG2211	Major facilitator Superfamily
NP434_11825	COG0346	lactoylglutathione lyase activity
NP434_11830	COG1072	(Pantothenic acid kinase))
NP434_11835	COG3048	D-serine ammonia-lyase activity
NP434_11840	COG0300	oxidoreductase activity
NP434_11845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP434_11850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP434_11855	COG4187	Peptidase family M20/M25/M40
NP434_11860	COG1902	pentaerythritol trinitrate reductase activity
NP434_11865	COG0596	Alpha beta hydrolase
NP434_11875	COG1234	tRNA 3'-trailer cleavage
NP434_11880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NP434_11885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP434_11890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP434_11900	COG0706	membrane insertase activity
NP434_11905	COG3361	conserved protein (COG2071)
NP434_11910	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP434_11915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP434_11920	COG0346	lactoylglutathione lyase activity
NP434_11930	COG1376	ErfK ybiS ycfS ynhG family protein
NP434_11935	COG4129	membrane
NP434_11940	COG1126	abc transporter atp-binding protein
NP434_11945	COG0765	amino acid transport
NP434_11950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP434_11960	COG1597	lipid kinase activity
NP434_11965	COG2814	Major facilitator Superfamily
NP434_11970	COG0789	Transcriptional regulator
NP434_11970	COG4978	Transcriptional regulator
NP434_11975	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP434_11980	COG0022	dehydrogenase e1 component
NP434_11985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP434_11990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP434_11995	COG3426	butyrate kinase activity
NP434_12000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP434_12005	COG0280	phosphate acetyltransferase
NP434_12010	COG3290	protein histidine kinase activity
NP434_12010	COG3829	transcription factor binding
NP434_12020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NP434_12025	COG2079	MmgE PrpD family protein
NP434_12030	COG0372	Belongs to the citrate synthase family
NP434_12035	COG1960	acyl-CoA dehydrogenase activity
NP434_12040	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP434_12045	COG0183	Belongs to the thiolase family
NP434_12050	COG0584	glycerophosphoryl diester phosphodiesterase
NP434_12055	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP434_12070	COG1902	pentaerythritol trinitrate reductase activity
NP434_12075	COG0745	RESPONSE REGULATOR receiver
NP434_12080	COG0750	zinc metalloprotease
NP434_12085	COG0497	DNA recombination
NP434_12090	COG1438	arginine binding
NP434_12095	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NP434_12100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NP434_12105	COG0142	geranyltranstransferase activity
NP434_12110	COG1722	exodeoxyribonuclease VII activity
NP434_12115	COG1570	exodeoxyribonuclease VII activity
NP434_12120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NP434_12125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP434_12130	COG1302	Protein conserved in bacteria
NP434_12135	COG0439	Biotin carboxylase
NP434_12140	COG0511	ligase activity, forming carbon-carbon bonds
NP434_12180	COG3854	ATPases associated with a variety of cellular activities
NP434_12190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NP434_12195	COG0006	proline dipeptidase activity
NP434_12200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NP434_12210	COG3872	metal-dependent enzyme
NP434_12220	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP434_12225	COG1321	iron dependent repressor
NP434_12230	COG0095	Lipoate-protein ligase
NP434_12235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP434_12240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP434_12245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP434_12250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NP434_12255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP434_12270	COG1396	sequence-specific DNA binding
NP434_12280	COG0681	Belongs to the peptidase S26 family
NP434_12305	COG4940	Competence protein ComGF
NP434_12315	COG4970	Tfp pilus assembly protein FimT
NP434_12320	COG4537	Required for transformation and DNA binding
NP434_12325	COG1459	type II secretion system
NP434_12330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP434_12335	COG0598	Magnesium transport protein CorA
NP434_12340	COG1253	flavin adenine dinucleotide binding
NP434_12345	COG1366	Belongs to the anti-sigma-factor antagonist family
NP434_12355	COG1393	Belongs to the ArsC family
NP434_12365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP434_12375	COG0011	TIGRFAM Protein of
NP434_12385	COG2866	Carboxypeptidase
NP434_12390	COG1368	sulfuric ester hydrolase activity
NP434_12395	COG1940	carbohydrate kinase activity
NP434_12400	COG4483	Protein conserved in bacteria
NP434_12405	COG0705	Rhomboid family
NP434_12405	COG0457	Tetratricopeptide repeat
NP434_12415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NP434_12425	COG0438	transferase activity, transferring glycosyl groups
NP434_12440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP434_12445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP434_12450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP434_12455	COG0581	inorganic phosphate transmembrane transporter activity
NP434_12460	COG0573	inorganic phosphate transmembrane transporter activity
NP434_12465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NP434_12470	COG0768	penicillin binding
NP434_12475	COG0477	Major facilitator Superfamily
NP434_12480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP434_12485	COG2839	Protein conserved in bacteria
NP434_12490	COG5521	maltodextrose utilization protein MalA
NP434_12495	COG1388	LysM domain
NP434_12500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NP434_12505	COG4709	membrane
NP434_12510	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NP434_12515	COG0735	belongs to the Fur family
NP434_12520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP434_12530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NP434_12535	COG0513	Belongs to the DEAD box helicase family
NP434_12545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NP434_12550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NP434_12555	COG2384	SAM-dependent methyltransferase
NP434_12560	COG2010	Cytochrome c
NP434_12565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NP434_12570	COG0358	DNA primase activity
NP434_12575	COG1671	Belongs to the UPF0178 family
NP434_12580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NP434_12585	COG0517	IMP dehydrogenase activity
NP434_12590	COG0751	glycine-tRNA ligase activity
NP434_12595	COG0752	glycyl-tRNA synthetase alpha subunit
NP434_12600	COG1381	Involved in DNA repair and RecF pathway recombination
NP434_12610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NP434_12615	COG0295	cytidine deaminase activity
NP434_12620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NP434_12625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NP434_12630	COG1480	7TM receptor with intracellular HD hydrolase
NP434_12635	COG1702	phosphate starvation-inducible protein PhoH
NP434_12640	COG0561	phosphatase activity
NP434_12655	COG4864	UPF0365 protein
NP434_12660	COG1030	water channel activity
NP434_12665	COG1610	YqeY-like protein
NP434_12675	COG1283	sodium-dependent phosphate transmembrane transporter activity
NP434_12680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP434_12685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NP434_12690	COG2264	protein methyltransferase activity
NP434_12695	COG0484	heat shock protein binding
NP434_12700	COG0443	Heat shock 70 kDa protein
NP434_12705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NP434_12710	COG1420	regulation of RNA biosynthetic process
NP434_12715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP434_12720	COG0481	GTPase activity
NP434_12730	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP434_12735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NP434_12740	COG0268	Binds directly to 16S ribosomal RNA
NP434_12745	COG1466	dna polymerase III delta subunit
NP434_12760	COG2333	competence protein COMEC
NP434_12760	COG0658	competence protein
NP434_12765	COG2131	deaminase
NP434_12770	COG1555	photosystem II stabilization
NP434_12770	COG1596	polysaccharide export
NP434_12775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP434_12780	COG2226	methyltransferase
NP434_12785	COG0799	negative regulation of ribosome biogenesis
NP434_12790	COG1713	HD superfamily hydrolase involved in NAD metabolism
NP434_12795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NP434_12800	COG1534	Rna-binding protein
NP434_12805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP434_12810	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP434_12815	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NP434_12825	COG2755	lipolytic protein G-D-S-L family
NP434_12830	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP434_12830	COG3409	Peptidoglycan-binding domain 1 protein
NP434_12835	COG0398	Pfam SNARE associated Golgi protein
NP434_12840	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NP434_12850	COG3209	COG3209 Rhs family protein
NP434_12875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP434_12880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP434_12885	COG0640	Transcriptional regulator
NP434_12890	COG0640	Transcriptional regulator
NP434_12925	COG0300	oxidoreductase activity
NP434_12930	COG1902	pentaerythritol trinitrate reductase activity
NP434_12935	COG0596	Alpha beta hydrolase
NP434_12935	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP434_12940	COG1309	transcriptional regulator
NP434_12950	COG1063	alcohol dehydrogenase
NP434_12965	COG0457	Tetratricopeptide repeat
NP434_12970	COG5444	nuclease activity
NP434_13000	COG5484	DNA packaging
NP434_13045	COG3677	Transposase
NP434_13055	COG3209	COG3209 Rhs family protein
NP434_13095	COG0563	adenylate kinase activity
NP434_13125	COG3223	Belongs to the PsiE family
NP434_13130	COG0642	Histidine kinase
NP434_13130	COG5002	protein histidine kinase activity
NP434_13135	COG0745	RESPONSE REGULATOR receiver
NP434_13140	COG2311	Membrane
NP434_13150	COG0454	-acetyltransferase
NP434_13155	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP434_13165	COG0730	response to heat
NP434_13170	COG0425	Belongs to the sulfur carrier protein TusA family
NP434_13185	COG0425	Belongs to the sulfur carrier protein TusA family
NP434_13185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP434_13190	COG2210	Belongs to the sulfur carrier protein TusA family
NP434_13195	COG1937	Protein conserved in bacteria
NP434_13205	COG0662	Cupin 2, conserved barrel domain protein
NP434_13220	COG0789	Transcriptional regulator
NP434_13220	COG4978	Transcriptional regulator
NP434_13225	COG2814	Major facilitator Superfamily
NP434_13230	COG0456	acetyltransferase
NP434_13235	COG1253	flavin adenine dinucleotide binding
NP434_13245	COG0697	spore germination
NP434_13250	COG0583	DNA-binding transcription factor activity
NP434_13255	COG2072	flavoprotein involved in K transport
NP434_13260	COG1230	cation diffusion facilitator family transporter
NP434_13265	COG1942	4-Oxalocrotonate Tautomerase
NP434_13270	COG0583	DNA-binding transcription factor activity
NP434_13280	COG1114	Component of the transport system for branched-chain amino acids
NP434_13285	COG1687	branched-chain amino acid
NP434_13290	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NP434_13295	COG1522	sequence-specific DNA binding
NP434_13300	COG2732	(Barnase) inhibitor
NP434_13305	COG2124	cytochrome p450
NP434_13310	COG1335	isochorismatase
NP434_13325	COG2318	DinB family
NP434_13335	COG2070	2-Nitropropane dioxygenase
NP434_13340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP434_13360	COG3443	Belongs to the bacterial solute-binding protein 9 family
NP434_13365	COG1595	DNA-templated transcription, initiation
NP434_13370	COG0667	Aldo Keto reductase
NP434_13375	COG2851	Citrate transporter
NP434_13380	COG0583	DNA-binding transcription factor activity
NP434_13385	COG2828	Protein conserved in bacteria
NP434_13390	COG3409	Peptidoglycan-binding domain 1 protein
NP434_13395	COG5566	PFAM Mor transcription activator
NP434_13400	COG0596	Alpha beta hydrolase
NP434_13405	COG4991	sh3 domain protein
NP434_13410	COG4991	sh3 domain protein
NP434_13420	COG0346	lactoylglutathione lyase activity
NP434_13430	COG5577	PFAM Coat F domain
NP434_13435	COG1063	alcohol dehydrogenase
NP434_13445	COG5577	PFAM Coat F domain
NP434_13450	COG0789	Transcriptional regulator
NP434_13460	COG1064	alcohol dehydrogenase
NP434_13465	COG0693	protein deglycase activity
NP434_13470	COG1621	beta-fructofuranosidase activity
NP434_13480	COG3716	PTS system mannose fructose sorbose family IID component
NP434_13485	COG3715	PTS system
NP434_13490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_13495	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP434_13500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP434_13500	COG3933	PFAM sigma-54 factor interaction domain-containing protein
NP434_13510	COG1113	amino acid transport
NP434_13515	COG1280	lysine exporter protein (LysE YggA)
NP434_13520	COG1378	Sugar-specific transcriptional regulator TrmB
NP434_13525	COG1595	DNA-templated transcription, initiation
NP434_13535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NP434_13535	COG2755	lipolytic protein G-D-S-L family
NP434_13545	COG2124	cytochrome p450
NP434_13545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP434_13550	COG1309	transcriptional regulator
NP434_13555	COG2226	methyltransferase
NP434_13570	COG2116	formate transmembrane transporter activity
NP434_13575	COG5609	conserved protein (DUF2294)
NP434_13580	COG3383	formate dehydrogenase (NAD+) activity
NP434_13585	COG2427	Protein of unknown function (DUF1641)
NP434_13595	COG0626	cystathionine gamma-synthase activity
NP434_13600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP434_13605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NP434_13610	COG2226	methyltransferase
NP434_13625	COG0768	penicillin binding
NP434_13630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP434_13635	COG0572	uridine kinase
NP434_13640	COG0826	peptidase U32
NP434_13645	COG0826	peptidase U32
NP434_13650	COG4122	O-methyltransferase activity
NP434_13655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP434_13660	COG3906	Belongs to the UPF0473 family
NP434_13665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NP434_13670	COG4472	Bacterial protein of unknown function (DUF965)
NP434_13675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NP434_13680	COG0628	permease
NP434_13685	COG1126	abc transporter atp-binding protein
NP434_13690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP434_13695	COG0765	amino acid transport
NP434_13700	COG0765	amino acid transport
NP434_13715	COG3881	PFAM PRC-barrel domain
NP434_13720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NP434_13725	COG0457	Tetratricopeptide repeat
NP434_13730	COG0482	sulfurtransferase activity
NP434_13735	COG1104	cysteine desulfurase activity
NP434_13740	COG1959	2 iron, 2 sulfur cluster binding
NP434_13745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NP434_13750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NP434_13760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NP434_13765	COG0124	histidyl-tRNA synthetase
NP434_13775	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP434_13775	COG3103	Sh3 type 3 domain protein
NP434_13775	COG4991	sh3 domain protein
NP434_13780	COG1490	D-aminoacyl-tRNA deacylase activity
NP434_13785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP434_13790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP434_13795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NP434_13795	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NP434_13800	COG5416	Lipopolysaccharide assembly protein A domain
NP434_13805	COG0490	domain, Protein
NP434_13810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP434_13810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP434_13820	COG2244	polysaccharide biosynthetic process
NP434_13825	COG2323	membrane
NP434_13835	COG1862	Preprotein translocase
NP434_13840	COG0343	queuine tRNA-ribosyltransferase activity
NP434_13845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NP434_13855	COG2255	four-way junction helicase activity
NP434_13860	COG0632	four-way junction helicase activity
NP434_13870	COG2814	Major facilitator Superfamily
NP434_13875	COG0673	inositol 2-dehydrogenase activity
NP434_13880	COG2112	serine threonine protein kinase
NP434_13905	COG1115	amino acid carrier protein
NP434_13910	COG0217	transcriptional regulatory protein
NP434_13920	COG1388	LysM domain
NP434_13925	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NP434_13930	COG0157	Belongs to the NadC ModD family
NP434_13935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NP434_13940	COG1104	cysteine desulfurase activity
NP434_13945	COG1827	regulation of RNA biosynthetic process
NP434_13950	COG0077	Prephenate dehydratase
NP434_13955	COG4492	Belongs to the UPF0735 family
NP434_13960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NP434_13965	COG3290	protein histidine kinase activity
NP434_13975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NP434_13980	COG2868	ribosomal protein
NP434_13985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NP434_13990	COG1994	Peptidase M50
NP434_13995	COG0739	heme binding
NP434_14000	COG2894	cell division
NP434_14005	COG0850	regulation of cytokinetic process
NP434_14010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NP434_14020	COG1077	Cell shape determining protein MreB Mrl
NP434_14025	COG2003	Belongs to the UPF0758 family
NP434_14030	COG0424	maF-like protein
NP434_14040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NP434_14045	COG0285	dihydrofolate synthase activity
NP434_14050	COG0525	valine-tRNA ligase activity
NP434_14060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP434_14065	COG1388	LysM domain
NP434_14070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP434_14075	COG0113	porphobilinogen synthase activity
NP434_14080	COG1587	Uroporphyrinogen-III synthase
NP434_14085	COG0181	hydroxymethylbilane synthase activity
NP434_14090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP434_14095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NP434_14105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NP434_14110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NP434_14115	COG0470	DNA polymerase III
NP434_14115	COG1067	ATP-dependent peptidase activity
NP434_14120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NP434_14125	COG0544	peptidyl-prolyl cis-trans isomerase activity
NP434_14130	COG1477	protein flavinylation
NP434_14130	COG0457	Tetratricopeptide repeat
NP434_14135	COG0066	3-isopropylmalate dehydratase activity
NP434_14140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NP434_14145	COG0473	3-isopropylmalate dehydrogenase activity
NP434_14150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP434_14155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NP434_14160	COG0440	acetolactate synthase activity
NP434_14165	COG0028	Belongs to the TPP enzyme family
NP434_14180	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NP434_14190	COG0622	Phosphoesterase
NP434_14195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NP434_14200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NP434_14205	COG5401	PFAM Sporulation and spore germination
NP434_14210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP434_14215	COG1846	Transcriptional regulator
NP434_14220	COG2197	response regulator
NP434_14225	COG0824	Thioesterase
NP434_14230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NP434_14235	COG1053	succinate dehydrogenase
NP434_14240	COG2009	succinate dehydrogenase
NP434_14245	COG1719	4-vinyl reductase, 4VR
NP434_14250	COG0527	aspartate kinase activity
NP434_14255	COG0322	excinuclease ABC activity
NP434_14260	COG3118	belongs to the thioredoxin family
NP434_14265	COG3534	alpha-L-arabinofuranosidase
NP434_14270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NP434_14275	COG2086	electron transfer activity
NP434_14280	COG1024	Enoyl-CoA hydratase
NP434_14285	COG1309	transcriptional regulator
NP434_14290	COG0318	PFAM AMP-dependent synthetase and ligase
NP434_14295	COG3766	membrane
NP434_14300	COG1193	negative regulation of DNA recombination
NP434_14305	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP434_14305	COG1796	DNA polymerase
NP434_14310	COG1286	toxin biosynthetic process
NP434_14315	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NP434_14320	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP434_14325	COG0072	phenylalanine-tRNA ligase activity
NP434_14325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP434_14330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NP434_14340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP434_14350	COG3835	regulator
NP434_14355	COG0277	FAD linked oxidase domain protein
NP434_14360	COG0247	lactate metabolic process
NP434_14365	COG0346	lactoylglutathione lyase activity
NP434_14375	COG1966	Carbon starvation protein
NP434_14380	COG3534	alpha-L-arabinofuranosidase
NP434_14385	COG0395	ABC-type sugar transport system, permease component
NP434_14390	COG1175	transmembrane transport
NP434_14395	COG1653	transport
NP434_14400	COG0371	Dehydrogenase
NP434_14405	COG0647	UMP catabolic process
NP434_14410	COG0235	Class ii aldolase
NP434_14415	COG1069	ribulokinase activity
NP434_14420	COG2160	L-arabinose isomerase activity
NP434_14425	COG3507	Belongs to the glycosyl hydrolase 43 family
NP434_14430	COG1363	Peptidase, m42
NP434_14440	COG3326	Membrane
NP434_14445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NP434_14450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NP434_14455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NP434_14465	COG1346	cytolysis
NP434_14470	COG1380	Effector of murein hydrolase LrgA
NP434_14475	COG3279	Response regulator of the LytR AlgR family
NP434_14480	COG3275	phosphorelay sensor kinase activity
NP434_14485	COG1011	Hydrolase
NP434_14490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP434_14500	COG0398	Pfam SNARE associated Golgi protein
NP434_14505	COG1484	DNA-dependent DNA replication
NP434_14510	COG3611	Membrane attachment protein
NP434_14515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NP434_14520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NP434_14525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP434_14530	COG1733	regulation of RNA biosynthetic process
NP434_14535	COG2814	Major facilitator Superfamily
NP434_14540	COG0656	L-ascorbic acid biosynthetic process
NP434_14545	COG0237	dephospho-CoA kinase activity
NP434_14555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NP434_14560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP434_14560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP434_14565	COG5002	protein histidine kinase activity
NP434_14570	COG0745	RESPONSE REGULATOR receiver
NP434_14575	COG0039	L-malate dehydrogenase activity
NP434_14580	COG0538	isocitrate dehydrogenase activity
NP434_14585	COG0372	Belongs to the citrate synthase family
NP434_14590	COG2707	UPF0756 membrane protein
NP434_14595	COG0628	permease
NP434_14600	COG3030	protein affecting phage T7 exclusion by the F plasmid
NP434_14605	COG0469	pyruvate kinase activity
NP434_14610	COG0205	6-phosphofructokinase activity
NP434_14615	COG0825	malonyl-CoA metabolic process
NP434_14620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NP434_14625	COG0281	malic enzyme
NP434_14630	COG0587	DNA-directed DNA polymerase activity
NP434_14650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NP434_14660	COG4109	DRTGG domain
NP434_14665	COG0730	response to heat
NP434_14670	COG1473	amidohydrolase
NP434_14675	COG0196	riboflavin kinase activity
NP434_14680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP434_14685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NP434_14690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP434_14695	COG1126	abc transporter atp-binding protein
NP434_14700	COG0765	amino acid transport
NP434_14705	COG0765	amino acid transport
NP434_14710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP434_14720	COG0454	-acetyltransferase
NP434_14725	COG0583	DNA-binding transcription factor activity
NP434_14730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NP434_14735	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_14745	COG0165	Argininosuccinate lyase
NP434_14750	COG0137	argininosuccinate synthase activity
NP434_14755	COG0521	Mo-molybdopterin cofactor biosynthetic process
NP434_14760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NP434_14770	COG0827	DNA restriction-modification system
NP434_14775	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NP434_14780	COG3874	Sporulation protein YtfJ
NP434_14790	COG1714	RDD family
NP434_14795	COG0616	signal peptide processing
NP434_14800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP434_14805	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NP434_14810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP434_14820	COG0301	tRNA thio-modification
NP434_14825	COG1104	cysteine desulfurase activity
NP434_14830	COG1114	Component of the transport system for branched-chain amino acids
NP434_14835	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NP434_14840	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP434_14845	COG1309	transcriptional regulator
NP434_14850	COG1956	GAF domain-containing protein
NP434_14855	COG2199	diguanylate cyclase activity
NP434_14855	COG2203	Gaf domain
NP434_14860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NP434_14870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP434_14875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP434_14880	COG0454	-acetyltransferase
NP434_14885	COG0517	IMP dehydrogenase activity
NP434_14890	COG0123	including yeast histone deacetylase and acetoin utilization protein
NP434_14895	COG1360	Flagellar Motor Protein
NP434_14900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP434_14905	COG1609	Transcriptional regulator
NP434_14910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NP434_14910	COG1605	Chorismate mutase
NP434_14915	COG3118	belongs to the thioredoxin family
NP434_14920	COG4980	gas vesicle protein
NP434_14925	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NP434_14930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP434_14935	COG1674	ftsk spoiiie
NP434_14940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP434_14945	COG4848	Belongs to the UPF0354 family
NP434_14950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP434_14965	COG1363	Peptidase, m42
NP434_14970	COG5584	Small secreted protein
NP434_14975	COG0281	malic enzyme
NP434_14980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP434_14985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NP434_14995	COG0510	thiamine kinase activity
NP434_15000	COG1523	belongs to the glycosyl hydrolase 13 family
NP434_15005	COG1597	lipid kinase activity
NP434_15015	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP434_15020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP434_15025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP434_15030	COG2252	PERMEase
NP434_15035	COG4473	ABC transporter
NP434_15040	COG1131	(ABC) transporter
NP434_15045	COG1349	DNA-binding transcription factor activity
NP434_15050	COG1187	pseudouridine synthase activity
NP434_15055	COG2244	polysaccharide biosynthetic process
NP434_15060	COG2081	HI0933 family
NP434_15065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP434_15075	COG5578	integral membrane protein
NP434_15080	COG0673	inositol 2-dehydrogenase activity
NP434_15085	COG1653	transport
NP434_15090	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NP434_15095	COG4209	transmembrane transport
NP434_15100	COG2207	Transcriptional regulator
NP434_15105	COG1653	transport
NP434_15110	COG0395	ABC-type sugar transport system, permease component
NP434_15115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP434_15120	COG2124	cytochrome p450
NP434_15125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NP434_15135	COG0156	8-amino-7-oxononanoate synthase activity
NP434_15140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP434_15150	COG1073	alpha beta
NP434_15155	COG1609	Transcriptional regulator
NP434_15160	COG1653	transport
NP434_15165	COG1175	transmembrane transport
NP434_15170	COG0395	ABC-type sugar transport system, permease component
NP434_15175	COG1486	melibiose metabolic process
NP434_15180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP434_15185	COG0495	leucyl-tRNA aminoacylation
NP434_15195	COG2202	Pas domain
NP434_15195	COG1366	Belongs to the anti-sigma-factor antagonist family
NP434_15200	COG2814	Major facilitator Superfamily
NP434_15205	COG2433	Pfam Transposase IS66
NP434_15210	COG0577	efflux transmembrane transporter activity
NP434_15215	COG1136	(ABC) transporter
NP434_15220	COG2205	protein histidine kinase activity
NP434_15225	COG0745	RESPONSE REGULATOR receiver
NP434_15230	COG0577	efflux transmembrane transporter activity
NP434_15235	COG1136	(ABC) transporter
NP434_15250	COG1131	(ABC) transporter
NP434_15255	COG1725	Transcriptional regulator
NP434_15270	COG1242	4 iron, 4 sulfur cluster binding
NP434_15275	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NP434_15285	COG2267	carboxylic ester hydrolase activity
NP434_15290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NP434_15295	COG1113	amino acid transport
NP434_15300	COG0367	asparagine synthase
NP434_15305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NP434_15310	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NP434_15320	COG1506	peptidase
NP434_15325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP434_15330	COG1116	anion transmembrane transporter activity
NP434_15335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP434_15340	COG0494	nUDIX hydrolase
NP434_15345	COG4824	toxin secretion phage lysis holin
NP434_15350	COG0783	Belongs to the Dps family
NP434_15365	COG1854	S-ribosylhomocysteine lyase activity
NP434_15370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NP434_15375	COG0288	reversible hydration of carbon dioxide
NP434_15380	COG0254	rRNA binding
NP434_15385	COG1271	oxidase subunit
NP434_15390	COG1294	oxidase, subunit
NP434_15400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP434_15405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP434_15405	COG1321	iron dependent repressor
NP434_15410	COG1121	(ABC) transporter
NP434_15415	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP434_15420	COG4948	Mandelate Racemase Muconate Lactonizing
NP434_15425	COG0318	PFAM AMP-dependent synthetase and ligase
NP434_15430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NP434_15435	COG0596	Alpha beta hydrolase
NP434_15440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NP434_15445	COG1169	isochorismate synthase
NP434_15450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP434_15455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP434_15460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP434_15465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP434_15470	COG0438	transferase activity, transferring glycosyl groups
NP434_15480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP434_15485	COG0438	transferase activity, transferring glycosyl groups
NP434_15490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP434_15500	COG0058	SHG alpha-glucan phosphorylase activity
NP434_15505	COG0297	glycogen (starch) synthase activity
NP434_15510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP434_15515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP434_15520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NP434_15645	COG3859	Proton-coupled thiamine transporter YuaJ
NP434_15650	COG1247	-acetyltransferase
NP434_15655	COG2268	Band 7 protein
NP434_15660	COG1585	Membrane protein implicated in regulation of membrane protease activity
NP434_15665	COG2318	DinB family
NP434_15675	COG1454	alcohol dehydrogenase
NP434_15680	COG1012	belongs to the aldehyde dehydrogenase family
NP434_15685	COG1510	regulation of RNA biosynthetic process
NP434_15695	COG0569	domain protein
NP434_15700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP434_15705	COG4682	membrane
NP434_15710	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP434_15715	COG0477	Major facilitator Superfamily
NP434_15720	COG5553	Cysteine dioxygenase type I
NP434_15730	COG1968	undecaprenyl-diphosphatase activity
NP434_15735	COG0628	permease
NP434_15740	COG0673	inositol 2-dehydrogenase activity
NP434_15745	COG4806	L-rhamnose isomerase
NP434_15750	COG3254	rhamnose metabolic process
NP434_15755	COG1070	Carbohydrate kinase
NP434_15760	COG1349	DNA-binding transcription factor activity
NP434_15765	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_15765	COG3347	Dehydrogenase
NP434_15770	COG0840	transmembrane signaling receptor activity
NP434_15775	COG0840	transmembrane signaling receptor activity
NP434_15780	COG0840	transmembrane signaling receptor activity
NP434_15785	COG0840	transmembrane signaling receptor activity
NP434_15800	COG0432	Pfam Uncharacterised protein family UPF0047
NP434_15810	COG0366	Alpha amylase catalytic
NP434_15815	COG1253	flavin adenine dinucleotide binding
NP434_15820	COG2738	Putative neutral zinc metallopeptidase
NP434_15835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NP434_15850	COG0166	Belongs to the GPI family
NP434_15855	COG1979	alcohol dehydrogenase
NP434_15860	COG1979	alcohol dehydrogenase
NP434_15865	COG2155	Conserved Protein
NP434_15870	COG1098	S1 RNA binding domain
NP434_15875	COG0436	Aminotransferase
NP434_15880	COG1522	sequence-specific DNA binding
NP434_15885	COG2267	carboxylic ester hydrolase activity
NP434_15895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NP434_15900	COG2205	protein histidine kinase activity
NP434_15910	COG5018	Exonuclease
NP434_15920	COG2814	Major facilitator Superfamily
NP434_15925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP434_15930	COG3011	Protein conserved in bacteria
NP434_15940	COG3290	protein histidine kinase activity
NP434_15945	COG4565	transcriptional regulatory protein
NP434_15950	COG1744	ABC transporter substrate-binding protein PnrA-like
NP434_15955	COG3845	ABC transporter
NP434_15960	COG4603	Belongs to the binding-protein-dependent transport system permease family
NP434_15965	COG1079	Belongs to the binding-protein-dependent transport system permease family
NP434_15970	COG3493	citrate carrier protein
NP434_15980	COG2111	Na H antiporter
NP434_15980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP434_15985	COG2111	Na H antiporter
NP434_15990	COG1006	Multisubunit Na H antiporter MnhC subunit
NP434_15995	COG0651	ATP synthesis coupled electron transport
NP434_16000	COG1863	multisubunit Na H antiporter MnhE subunit
NP434_16005	COG2212	antiporter activity
NP434_16010	COG1320	monovalent cation:proton antiporter activity
NP434_16015	COG2050	protein possibly involved in aromatic compounds catabolism
NP434_16020	COG2197	response regulator
NP434_16025	COG4585	Histidine kinase
NP434_16035	COG0142	geranyltranstransferase activity
NP434_16055	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NP434_16060	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NP434_16065	COG1335	isochorismatase
NP434_16070	COG5506	Protein of unknown function (DUF1694)
NP434_16085	COG0628	permease
NP434_16100	COG1418	mRNA catabolic process
NP434_16105	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_16115	COG1511	domain protein
NP434_16120	COG0433	COG0433 Predicted ATPase
NP434_16120	COG1674	ftsk spoiiie
NP434_16125	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP434_16130	COG5417	Belongs to the EsaB family
NP434_16135	COG4842	Belongs to the WXG100 family
NP434_16140	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP434_16140	COG2508	Transcriptional regulator
NP434_16145	COG0686	Belongs to the AlaDH PNT family
NP434_16150	COG5634	Uncharacterized conserved protein (DUF2278)
NP434_16155	COG3251	PFAM MbtH domain protein
NP434_16160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_16165	COG3433	isochorismatase activity
NP434_16165	COG1535	isochorismatase
NP434_16170	COG1021	2,3-dihydroxybenzoate-AMP ligase
NP434_16175	COG1169	isochorismate synthase
NP434_16180	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_16185	COG2819	hydrolase of the alpha beta superfamily
NP434_16190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP434_16195	COG1268	BioY protein
NP434_16200	COG2056	Na+-H+ antiporter family
NP434_16205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NP434_16210	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NP434_16215	COG3584	3D domain protein
NP434_16230	COG1252	NADH dehydrogenase
NP434_16235	COG0492	ferredoxin-NADP+ reductase activity
NP434_16245	COG0516	GMP reductase activity
NP434_16250	COG2808	Putative FMN-binding domain
NP434_16255	COG0456	acetyltransferase
NP434_16260	COG0316	Belongs to the HesB IscA family
NP434_16265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NP434_16270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP434_16275	COG4844	belongs to the
NP434_16280	COG1252	NADH dehydrogenase
NP434_16285	COG4837	Protein of unknown function (DUF1462)
NP434_16290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NP434_16295	COG4946	Tricorn protease homolog
NP434_16295	COG1506	peptidase
NP434_16295	COG0823	Involved in the tonB-independent uptake of proteins
NP434_16300	COG0083	homoserine kinase activity
NP434_16305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NP434_16310	COG0460	homoserine dehydrogenase
NP434_16315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP434_16320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP434_16325	COG0647	UMP catabolic process
NP434_16330	COG2445	Protein of unknown function DUF86
NP434_16335	COG4470	Protein conserved in bacteria
NP434_16345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NP434_16350	COG0739	heme binding
NP434_16360	COG3377	Domain of unknown function (DUF1805)
NP434_16365	COG0737	Belongs to the 5'-nucleotidase family
NP434_16370	COG0730	response to heat
NP434_16375	COG1801	Protein of unknown function DUF72
NP434_16385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP434_16390	COG2508	Transcriptional regulator
NP434_16395	COG2233	PERMEase
NP434_16400	COG2233	PERMEase
NP434_16405	COG3195	allantoin biosynthetic process
NP434_16405	COG3648	Uricase
NP434_16410	COG2351	hydroxyisourate hydrolase activity
NP434_16420	COG2080	2 iron, 2 sulfur cluster binding
NP434_16425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NP434_16430	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NP434_16435	COG2068	MobA-Related Protein
NP434_16440	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NP434_16445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NP434_16450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP434_16460	COG2356	endonuclease I
NP434_16465	COG3842	ATPase activity
NP434_16470	COG2188	Transcriptional regulator
NP434_16475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP434_16480	COG0395	ABC-type sugar transport system, permease component
NP434_16485	COG1175	transmembrane transport
NP434_16490	COG1653	transport
NP434_16495	COG2222	sugar isomerase
NP434_16500	COG0322	excinuclease ABC activity
NP434_16505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP434_16530	COG0719	Fe-S assembly protein
NP434_16535	COG0822	iron-sulfur transferase activity
NP434_16540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP434_16545	COG0719	Fe-S assembly protein
NP434_16550	COG0396	ATPase activity
NP434_16560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NP434_16565	COG1464	Belongs to the NlpA lipoprotein family
NP434_16570	COG2011	ABC-type metal ion transport system permease component
NP434_16575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NP434_16585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP434_16590	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP434_16600	COG0509	glycine decarboxylation via glycine cleavage system
NP434_16605	COG1393	Belongs to the ArsC family
NP434_16610	COG1960	acyl-CoA dehydrogenase activity
NP434_16615	COG0183	Belongs to the thiolase family
NP434_16620	COG1024	Enoyl-CoA hydratase
NP434_16620	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP434_16630	COG0506	proline dehydrogenase activity
NP434_16640	COG5577	PFAM Coat F domain
NP434_16645	COG1846	Transcriptional regulator
NP434_16650	COG0477	Major facilitator Superfamily
NP434_16655	COG1942	4-Oxalocrotonate Tautomerase
NP434_16660	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_16665	COG0583	DNA-binding transcription factor activity
NP434_16675	COG1120	ATPase activity
NP434_16690	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_16695	COG0783	Belongs to the Dps family
NP434_16700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP434_16705	COG0745	RESPONSE REGULATOR receiver
NP434_16710	COG2770	Histidine kinase
NP434_16710	COG2205	protein histidine kinase activity
NP434_16720	COG1309	transcriptional regulator
NP434_16725	COG0114	fumarate hydratase activity
NP434_16735	COG0697	spore germination
NP434_16740	COG0814	amino acid
NP434_16750	COG2197	response regulator
NP434_16755	COG4585	Histidine kinase
NP434_16760	COG4758	membrane
NP434_16765	COG3595	metallopeptidase activity
NP434_16770	COG1842	Phage shock protein A
NP434_16775	COG4758	membrane
NP434_16780	COG2814	Major facilitator Superfamily
NP434_16785	COG2096	Adenosyltransferase
NP434_16790	COG1120	ATPase activity
NP434_16795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_16800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP434_16805	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_16810	COG3386	PFAM SMP-30 Gluconolaconase
NP434_16815	COG2205	protein histidine kinase activity
NP434_16820	COG0745	RESPONSE REGULATOR receiver
NP434_16830	COG1191	sigma factor activity
NP434_16840	COG2140	Oxalate decarboxylase
NP434_16850	COG0577	efflux transmembrane transporter activity
NP434_16855	COG1136	(ABC) transporter
NP434_16860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP434_16865	COG1120	ATPase activity
NP434_16870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_16875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP434_16880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP434_16885	COG0531	amino acid
NP434_16895	COG1988	membrane-bound metal-dependent
NP434_16900	COG1368	sulfuric ester hydrolase activity
NP434_16905	COG1910	domain protein
NP434_16910	COG0725	ABC transporter, periplasmic molybdate-binding protein
NP434_16915	COG4149	molybdate abc transporter
NP434_16920	COG0656	L-ascorbic acid biosynthetic process
NP434_16930	COG0025	NhaP-type Na H and K H
NP434_16935	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP434_16940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP434_16945	COG3973	AAA domain
NP434_16950	COG2860	membrane
NP434_16955	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NP434_16960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP434_16965	COG2217	Heavy metal translocating P-type atpase
NP434_16970	COG2217	Heavy metal translocating P-type atpase
NP434_16975	COG2608	mercury ion transmembrane transporter activity
NP434_16980	COG1937	Protein conserved in bacteria
NP434_16985	COG0673	inositol 2-dehydrogenase activity
NP434_16990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP434_16995	COG1289	transmembrane transporter activity
NP434_17005	COG2076	Multidrug Resistance protein
NP434_17010	COG1309	transcriptional regulator
NP434_17015	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_17025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NP434_17030	COG0557	exoribonuclease II activity
NP434_17035	COG1647	Serine aminopeptidase, S33
NP434_17040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP434_17045	COG0596	Alpha beta hydrolase
NP434_17050	COG1476	TRANSCRIPTIONal
NP434_17055	COG1396	sequence-specific DNA binding
NP434_17060	COG1396	sequence-specific DNA binding
NP434_17065	COG1733	regulation of RNA biosynthetic process
NP434_17070	COG0840	transmembrane signaling receptor activity
NP434_17075	COG1174	glycine betaine transport
NP434_17080	COG1732	Glycine betaine
NP434_17085	COG1174	glycine betaine transport
NP434_17090	COG0517	IMP dehydrogenase activity
NP434_17090	COG1125	glycine betaine transport
NP434_17095	COG1510	regulation of RNA biosynthetic process
NP434_17100	COG1174	glycine betaine transport
NP434_17105	COG1732	Glycine betaine
NP434_17110	COG1174	glycine betaine transport
NP434_17115	COG1125	glycine betaine transport
NP434_17115	COG0517	IMP dehydrogenase activity
NP434_17120	COG1510	regulation of RNA biosynthetic process
NP434_17125	COG2095	MarC family integral membrane protein
NP434_17135	COG3064	Membrane
NP434_17140	COG4640	response to antibiotic
NP434_17145	COG0456	acetyltransferase
NP434_17150	COG0148	phosphopyruvate hydratase activity
NP434_17155	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NP434_17160	COG0149	triose-phosphate isomerase activity
NP434_17165	COG0126	phosphoglycerate kinase activity
NP434_17170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP434_17175	COG2390	Transcriptional regulator
NP434_17180	COG2814	Major facilitator Superfamily
NP434_17185	COG1609	Transcriptional regulator
NP434_17190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP434_17195	COG0583	DNA-binding transcription factor activity
NP434_17200	COG0697	spore germination
NP434_17205	COG1113	amino acid transport
NP434_17210	COG3858	chitin binding
NP434_17215	COG1556	Lactate utilization protein
NP434_17220	COG1139	Iron-sulfur cluster binding protein
NP434_17225	COG0247	lactate metabolic process
NP434_17230	COG2197	response regulator
NP434_17235	COG4585	Histidine kinase
NP434_17240	COG0842	Transport permease protein
NP434_17245	COG1131	(ABC) transporter
NP434_17250	COG0596	Alpha beta hydrolase
NP434_17255	COG2208	phosphoserine phosphatase activity
NP434_17260	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NP434_17265	COG1874	Beta-galactosidase
NP434_17270	COG3833	ABC-type maltose transport systems, permease component
NP434_17275	COG1175	transmembrane transport
NP434_17280	COG2182	Extracellular solute-binding protein
NP434_17285	COG1609	Transcriptional regulator
NP434_17290	COG2186	Transcriptional regulator
NP434_17295	COG1620	l-lactate permease
NP434_17300	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NP434_17310	COG5039	Polysaccharide pyruvyl transferase
NP434_17315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP434_17320	COG0110	maltose O-acetyltransferase activity
NP434_17325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP434_17330	COG2244	polysaccharide biosynthetic process
NP434_17335	COG1216	Glycosyl transferase, family 2
NP434_17340	COG5039	Polysaccharide pyruvyl transferase
NP434_17345	COG1216	Glycosyl transferase, family 2
NP434_17355	COG0438	transferase activity, transferring glycosyl groups
NP434_17360	COG1215	transferase activity, transferring glycosyl groups
NP434_17365	COG0438	transferase activity, transferring glycosyl groups
NP434_17370	COG1086	Polysaccharide biosynthesis protein
NP434_17375	COG0489	protein tyrosine kinase activity
NP434_17380	COG3944	biosynthesis protein
NP434_17385	COG1396	sequence-specific DNA binding
NP434_17390	COG2272	Belongs to the type-B carboxylesterase lipase family
NP434_17400	COG3479	Phenolic acid decarboxylase
NP434_17410	COG1794	racemase activity, acting on amino acids and derivatives
NP434_17415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP434_17420	COG1621	beta-fructofuranosidase activity
NP434_17425	COG1621	beta-fructofuranosidase activity
NP434_17430	COG0531	amino acid
NP434_17435	COG1309	transcriptional regulator
NP434_17440	COG2076	Multidrug Resistance protein
NP434_17445	COG2076	Multidrug Resistance protein
NP434_17455	COG0277	FAD linked oxidase domain protein
NP434_17460	COG3621	Patatin-like phospholipase
NP434_17470	COG0740	serine-type endopeptidase activity
NP434_17480	COG0366	Alpha amylase catalytic
NP434_17485	COG1554	hydrolase, family 65, central catalytic
NP434_17490	COG5521	maltodextrose utilization protein MalA
NP434_17495	COG3833	ABC-type maltose transport systems, permease component
NP434_17500	COG1175	transmembrane transport
NP434_17505	COG2182	Extracellular solute-binding protein
NP434_17515	COG1609	Transcriptional regulator
NP434_17520	COG1611	Belongs to the LOG family
NP434_17525	COG1694	Mazg nucleotide pyrophosphohydrolase
NP434_17530	COG0659	secondary active sulfate transmembrane transporter activity
NP434_17535	COG0288	reversible hydration of carbon dioxide
NP434_17540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP434_17545	COG0577	efflux transmembrane transporter activity
NP434_17550	COG1136	(ABC) transporter
NP434_17555	COG5002	protein histidine kinase activity
NP434_17560	COG0745	RESPONSE REGULATOR receiver
NP434_17570	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NP434_17575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP434_17580	COG1481	regulation of sporulation
NP434_17585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NP434_17590	COG1660	Displays ATPase and GTPase activities
NP434_17595	COG1051	belongs to the nudix hydrolase family
NP434_17600	COG0492	ferredoxin-NADP+ reductase activity
NP434_17605	COG3883	PFAM NLP P60 protein
NP434_17605	COG0791	NLP P60 protein
NP434_17610	COG0457	Tetratricopeptide repeat
NP434_17615	COG1132	(ABC) transporter
NP434_17640	COG0140	phosphoribosyl-ATP diphosphatase activity
NP434_17640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NP434_17645	COG0107	imidazoleglycerol-phosphate synthase activity
NP434_17650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NP434_17655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NP434_17660	COG0131	Imidazoleglycerol-phosphate dehydratase
NP434_17665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NP434_17670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NP434_17675	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NP434_17680	COG4990	cell redox homeostasis
NP434_17685	COG5297	Belongs to the glycosyl hydrolase family 6
NP434_17690	COG0110	maltose O-acetyltransferase activity
NP434_17695	COG0546	phosphoglycolate phosphatase activity
NP434_17700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NP434_17705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NP434_17710	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NP434_17715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NP434_17720	COG0363	glucosamine-6-phosphate deaminase activity
NP434_17725	COG2188	Transcriptional regulator
NP434_17730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NP434_17735	COG1846	Transcriptional regulator
NP434_17740	COG2124	cytochrome p450
NP434_17750	COG1846	Transcriptional regulator
NP434_17755	COG2814	Major facilitator Superfamily
NP434_17760	COG1950	PFAM Membrane protein of
NP434_17765	COG1983	PspC domain protein
NP434_17770	COG3595	metallopeptidase activity
NP434_17785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP434_17790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NP434_17795	COG0556	nucleotide-excision repair
NP434_17800	COG4897	Protein conserved in bacteria
NP434_17805	COG3848	Pyruvate phosphate dikinase
NP434_17805	COG0574	Belongs to the PEP-utilizing enzyme family
NP434_17810	COG1309	transcriptional regulator
NP434_17815	COG2814	Major facilitator Superfamily
NP434_17820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP434_17830	COG3409	Peptidoglycan-binding domain 1 protein
NP434_17830	COG0793	Belongs to the peptidase S41A family
NP434_17835	COG2177	Part of the ABC transporter FtsEX involved in
NP434_17840	COG2884	Cell division ATP-binding protein ftsE
NP434_17845	COG2010	Cytochrome c
NP434_17850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP434_17860	COG0653	protein targeting
NP434_17865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP434_17880	COG1516	flagellar protein fliS
NP434_17885	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NP434_17890	COG1334	flagellar protein FlaG
NP434_17895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP434_17900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NP434_17905	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NP434_17915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP434_17920	COG4786	Flagellar basal body rod
NP434_17920	COG1256	bacterial-type flagellum assembly
NP434_17925	COG3418	PFAM FlgN family protein
NP434_17930	COG2747	anti-sigma28 factor FlgM
NP434_17940	COG1040	competence protein
NP434_17950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NP434_17955	COG1307	EDD domain protein, DegV family
NP434_17960	COG2197	response regulator
NP434_17965	COG4585	Histidine kinase
NP434_17970	COG1739	Uncharacterized protein family UPF0029
NP434_17975	COG1316	TRANSCRIPTIONal
NP434_17980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP434_17985	COG0438	transferase activity, transferring glycosyl groups
NP434_17990	COG1215	transferase activity, transferring glycosyl groups
NP434_17995	COG3206	protein involved in exopolysaccharide biosynthesis
NP434_18000	COG3307	-O-antigen
NP434_18005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP434_18010	COG0438	transferase activity, transferring glycosyl groups
NP434_18010	COG0297	glycogen (starch) synthase activity
NP434_18015	COG2244	polysaccharide biosynthetic process
NP434_18030	COG2247	cell wall binding repeat
NP434_18030	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP434_18035	COG2247	cell wall binding repeat
NP434_18035	COG2385	sporulation resulting in formation of a cellular spore
NP434_18045	COG1316	TRANSCRIPTIONal
NP434_18050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NP434_18070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP434_18075	COG1134	teichoic acid transport
NP434_18080	COG1682	transport, permease protein
NP434_18085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP434_18085	COG1215	transferase activity, transferring glycosyl groups
NP434_18090	COG0463	Glycosyl transferase, family 2
NP434_18135	COG4193	domain, Protein
NP434_18140	COG1482	cell wall glycoprotein biosynthetic process
NP434_18145	COG0697	spore germination
NP434_18150	COG0814	amino acid
NP434_18160	COG2814	Major facilitator Superfamily
NP434_18165	COG1316	TRANSCRIPTIONal
NP434_18170	COG0561	phosphatase activity
NP434_18175	COG0791	NLP P60 protein
NP434_18185	COG2843	Capsule synthesis protein
NP434_18195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP434_18200	COG1609	Transcriptional regulator
NP434_18205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP434_18210	COG1869	D-ribose catabolic process
NP434_18215	COG1129	ABC transporter
NP434_18220	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP434_18225	COG1879	ABC-type sugar transport system periplasmic component
NP434_18230	COG3103	Sh3 type 3 domain protein
NP434_18240	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP434_18245	COG3527	Alpha-acetolactate decarboxylase
NP434_18250	COG0028	Belongs to the TPP enzyme family
NP434_18255	COG0583	DNA-binding transcription factor activity
NP434_18260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP434_18275	COG5337	Spore coat protein CotH
NP434_18285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP434_18295	COG0405	Gamma-glutamyltransferase
NP434_18300	COG1522	sequence-specific DNA binding
NP434_18305	COG2059	Chromate
NP434_18310	COG2059	Chromate
NP434_18320	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP434_18325	COG0583	DNA-binding transcription factor activity
NP434_18340	COG5444	nuclease activity
NP434_18360	COG3878	Protein conserved in bacteria
NP434_18365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP434_18370	COG4464	protein tyrosine phosphatase activity
NP434_18375	COG0489	protein tyrosine kinase activity
NP434_18380	COG3944	biosynthesis protein
NP434_18390	COG4715	Zinc finger, swim domain protein
NP434_18395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP434_18400	COG0561	phosphatase activity
NP434_18405	COG1349	DNA-binding transcription factor activity
NP434_18410	COG0629	single-stranded DNA binding
NP434_18425	COG3764	Sortase (surface protein transpeptidase)
NP434_18435	COG3279	Response regulator of the LytR AlgR family
NP434_18445	COG0745	RESPONSE REGULATOR receiver
NP434_18445	COG2972	Histidine kinase
NP434_18450	COG1970	mechanosensitive ion channel activity
NP434_18455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP434_18460	COG0457	Tetratricopeptide repeat
NP434_18465	COG4786	Flagellar basal body rod
NP434_18470	COG4786	Flagellar basal body rod
NP434_18475	COG1077	Cell shape determining protein MreB Mrl
NP434_18480	COG1609	Transcriptional regulator
NP434_18490	COG1846	Transcriptional regulator
NP434_18495	COG2814	Major facilitator Superfamily
NP434_18505	COG3420	alginic acid biosynthetic process
NP434_18510	COG1953	Uracil, thiamine, allantoin
NP434_18515	COG0477	Major facilitator Superfamily
NP434_18520	COG1335	isochorismatase
NP434_18530	COG0004	ammonium transporteR
NP434_18535	COG0347	Belongs to the P(II) protein family
NP434_18540	COG0671	phosphoesterase, PA-phosphatase related
NP434_18550	COG0739	heme binding
NP434_18555	COG1247	-acetyltransferase
NP434_18575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP434_18590	COG2910	NAD(P)H-binding
NP434_18595	COG1959	2 iron, 2 sulfur cluster binding
NP434_18600	COG0804	urea catabolic process
NP434_18605	COG0832	Belongs to the urease beta subunit family
NP434_18610	COG0831	urea catabolic process
NP434_18625	COG3237	CsbD-like
NP434_18630	COG1994	Peptidase M50
NP434_18635	COG0457	Tetratricopeptide repeat
NP434_18640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NP434_18645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NP434_18655	COG2304	oxidoreductase activity
NP434_18665	COG2304	oxidoreductase activity
NP434_18670	COG2385	sporulation resulting in formation of a cellular spore
NP434_18675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP434_18685	COG4836	Membrane
NP434_18695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NP434_18700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NP434_18705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NP434_18710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NP434_18715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP434_18720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NP434_18730	COG0356	it plays a direct role in the translocation of protons across the membrane
NP434_18740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NP434_18745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP434_18750	COG4475	Protein of unknown function (DUF436)
NP434_18755	COG0698	ribose 5-phosphate isomerase
NP434_18760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP434_18765	COG1971	Probably functions as a manganese efflux pump
NP434_18770	COG0009	L-threonylcarbamoyladenylate synthase
NP434_18775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NP434_18795	COG2890	protein-(glutamine-N5) methyltransferase activity
NP434_18800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NP434_18805	COG0346	lactoylglutathione lyase activity
NP434_18810	COG0789	Transcriptional regulator
NP434_18815	COG0679	Auxin Efflux Carrier
NP434_18820	COG0281	malic enzyme
NP434_18825	COG1435	thymidine kinase activity
NP434_18835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NP434_18845	COG1494	fructose-1,6-bisphosphatase
NP434_18850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP434_18855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NP434_18860	COG0191	fructose-bisphosphate aldolase activity
NP434_18865	COG2204	response regulator
NP434_18870	COG4821	SIS domain
NP434_18875	COG0504	CTP synthase activity
NP434_18880	COG3343	RNA polymerase activity
NP434_18885	COG1960	acyl-CoA dehydrogenase activity
NP434_18890	COG0247	lactate metabolic process
NP434_18890	COG2181	nitrate reductase activity
NP434_18895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP434_18900	COG4294	response to UV
NP434_18910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP434_18915	COG1132	(ABC) transporter
NP434_18920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP434_18930	COG2181	nitrate reductase activity
NP434_18935	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NP434_18940	COG1140	nitrate reductase beta subunit
NP434_18945	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NP434_18950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP434_18960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP434_18965	COG2223	nitrite transmembrane transporter activity
NP434_18970	COG0018	arginyl-trna synthetase
NP434_18975	COG4506	Protein conserved in bacteria
NP434_18990	COG0535	radical SAM domain protein
NP434_19000	COG1131	(ABC) transporter
NP434_19005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP434_19010	COG0612	Peptidase, M16
NP434_19015	COG0612	Peptidase, M16
NP434_19025	COG3391	amine dehydrogenase activity
NP434_19030	COG3391	amine dehydrogenase activity
NP434_19035	COG0457	Tetratricopeptide repeat
NP434_19050	COG0010	Belongs to the arginase family
NP434_19055	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NP434_19060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP434_19070	COG1994	Peptidase M50
NP434_19075	COG1942	4-Oxalocrotonate Tautomerase
NP434_19080	COG1846	Transcriptional regulator
NP434_19085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP434_19095	COG0477	Major facilitator Superfamily
NP434_19100	COG1959	2 iron, 2 sulfur cluster binding
NP434_19105	COG3465	dGTPase activity
NP434_19110	COG1078	dGTPase activity
NP434_19115	COG4844	belongs to the
NP434_19125	COG0697	spore germination
NP434_19130	COG0095	Lipoate-protein ligase
NP434_19135	COG0583	DNA-binding transcription factor activity
NP434_19140	COG0280	phosphate acetyltransferase
NP434_19145	COG3253	May function as heme-dependent peroxidase
NP434_19150	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_19155	COG0436	Aminotransferase
NP434_19160	COG2814	Major facilitator Superfamily
NP434_19165	COG0151	Belongs to the GarS family
NP434_19170	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_19175	COG1917	Cupin 2, conserved barrel domain protein
NP434_19180	COG0077	Prephenate dehydratase
NP434_19185	COG2814	Major facilitator Superfamily
NP434_19190	COG0833	amino acid
NP434_19195	COG4187	Peptidase family M20/M25/M40
NP434_19200	COG1012	belongs to the aldehyde dehydrogenase family
NP434_19205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP434_19215	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NP434_19220	COG1091	dTDP-4-dehydrorhamnose reductase activity
NP434_19225	COG1088	dTDP-glucose 4,6-dehydratase activity
NP434_19230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NP434_19235	COG3980	spore coat polysaccharide biosynthesis protein
NP434_19240	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NP434_19245	COG2089	acid synthase
NP434_19250	COG0456	acetyltransferase
NP434_19255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP434_19260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP434_19265	COG0463	Glycosyl transferase, family 2
NP434_19275	COG2363	Small membrane protein
NP434_19280	COG2233	PERMEase
NP434_19290	COG1012	belongs to the aldehyde dehydrogenase family
NP434_19295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NP434_19300	COG1216	Glycosyl transferase, family 2
NP434_19315	COG1695	Transcriptional regulator
NP434_19320	COG0351	phosphomethylpyrimidine kinase
NP434_19330	COG1621	beta-fructofuranosidase activity
NP434_19335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_19335	COG1263	PTS System
NP434_19340	COG2116	formate transmembrane transporter activity
NP434_19345	COG3711	transcriptional antiterminator
NP434_19355	COG1404	Belongs to the peptidase S8 family
NP434_19360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP434_19365	COG0778	Nitroreductase
NP434_19370	COG0772	Belongs to the SEDS family
NP434_19380	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP434_19385	COG1845	cytochrome c oxidase, subunit III
NP434_19390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP434_19395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP434_19400	COG2261	transglycosylase associated protein
NP434_19405	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NP434_19410	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NP434_19415	COG2246	polysaccharide biosynthetic process
NP434_19420	COG1309	transcriptional regulator
NP434_19430	COG3162	membrane
NP434_19435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP434_19440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP434_19445	COG2837	iron assimilation
NP434_19450	COG2822	iron ion transport
NP434_19455	COG0672	)-iron permease
NP434_19460	COG0352	thiamine-phosphate diphosphorylase activity
NP434_19465	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NP434_19470	COG0583	DNA-binding transcription factor activity
NP434_19475	COG1380	Effector of murein hydrolase LrgA
NP434_19480	COG1346	cytolysis
NP434_19490	COG4895	conserved protein (DUF2196)
NP434_19495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NP434_19500	COG0346	lactoylglutathione lyase activity
NP434_19505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP434_19510	COG1404	Belongs to the peptidase S8 family
NP434_19515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_19515	COG1263	PTS System
NP434_19520	COG3711	transcriptional antiterminator
NP434_19525	COG1442	glycosyl transferase family 8
NP434_19530	COG5522	Integral membrane protein (intg_mem_TP0381)
NP434_19535	COG1846	Transcriptional regulator
NP434_19540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP434_19545	COG2234	aminopeptidase activity
NP434_19560	COG2814	Major facilitator Superfamily
NP434_19565	COG2357	RelA SpoT domain protein
NP434_19570	COG1575	Belongs to the MenA family. Type 1 subfamily
NP434_19585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP434_19590	COG1696	Membrane protein involved in D-alanine export
NP434_19595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP434_19600	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NP434_19605	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NP434_19610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP434_19615	COG1486	melibiose metabolic process
NP434_19620	COG1447	Phosphotransferase system cellobiose-specific component IIA
NP434_19625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP434_19630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP434_19635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP434_19635	COG3711	transcriptional antiterminator
NP434_19645	COG2094	Belongs to the DNA glycosylase MPG family
NP434_19650	COG0753	catalase activity
NP434_19655	COG2814	Major facilitator Superfamily
NP434_19660	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP434_19665	COG1131	(ABC) transporter
NP434_19685	COG1595	DNA-templated transcription, initiation
NP434_19690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NP434_19695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NP434_19700	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NP434_19705	COG4988	ABC transporter
NP434_19710	COG1294	oxidase, subunit
NP434_19715	COG1271	oxidase subunit
NP434_19720	COG3493	citrate carrier protein
NP434_19725	COG0501	Belongs to the peptidase M48B family
NP434_19735	COG0726	polysaccharide deacetylase
NP434_19740	COG3842	ATPase activity
NP434_19745	COG2508	Transcriptional regulator
NP434_19750	COG1012	belongs to the aldehyde dehydrogenase family
NP434_19755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP434_19765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NP434_19775	COG4585	Histidine kinase
NP434_19780	COG2197	response regulator
NP434_19785	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP434_19800	COG4894	glucomannan catabolic process
NP434_19805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP434_19810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP434_19815	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_19820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP434_19825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP434_19830	COG2610	gluconate transmembrane transporter activity
NP434_19835	COG0500	methyltransferase
NP434_19840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP434_19855	COG0693	protein deglycase activity
NP434_19855	COG0753	catalase activity
NP434_19860	COG2851	Citrate transporter
NP434_19865	COG2273	Hydrolase Family 16
NP434_19870	COG3711	transcriptional antiterminator
NP434_19880	COG2270	Major facilitator Superfamily
NP434_19885	COG0513	Belongs to the DEAD box helicase family
NP434_19890	COG3401	FG-GAP repeat protein
NP434_19890	COG2755	lipolytic protein G-D-S-L family
NP434_19960	COG3209	COG3209 Rhs family protein
NP434_19965	COG0697	spore germination
NP434_19975	COG2723	6-phospho-beta-galactosidase activity
NP434_19980	COG1263	PTS System
NP434_19980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP434_19980	COG2190	(PTS) system
NP434_20030	COG5444	nuclease activity
NP434_20055	COG0494	nUDIX hydrolase
NP434_20060	COG3507	Belongs to the glycosyl hydrolase 43 family
NP434_20075	COG2986	histidine ammonia-lyase
NP434_20080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NP434_20085	COG1228	amidohydrolase
NP434_20090	COG0010	Belongs to the arginase family
NP434_20095	COG0833	amino acid
NP434_20100	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NP434_20105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP434_20110	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NP434_20115	COG2390	Transcriptional regulator
NP434_20125	COG3192	ethanolamine utilization protein
NP434_20130	COG2079	MmgE PrpD family protein
NP434_20135	COG1473	amidohydrolase
NP434_20140	COG1126	abc transporter atp-binding protein
NP434_20145	COG0765	amino acid transport
NP434_20150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP434_20155	COG0456	acetyltransferase
NP434_20160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP434_20170	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
NP434_20175	COG0561	phosphatase activity
NP434_20205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP434_20210	COG5294	Protein conserved in bacteria
NP434_20215	COG0577	efflux transmembrane transporter activity
NP434_20220	COG1136	(ABC) transporter
NP434_20225	COG2205	protein histidine kinase activity
NP434_20230	COG0745	RESPONSE REGULATOR receiver
NP434_20235	COG0191	fructose-bisphosphate aldolase activity
NP434_20240	COG1082	Xylose isomerase domain protein TIM barrel
NP434_20245	COG1082	Xylose isomerase domain protein TIM barrel
NP434_20250	COG0673	inositol 2-dehydrogenase activity
NP434_20255	COG2814	Major facilitator Superfamily
NP434_20260	COG1082	Xylose isomerase domain protein TIM barrel
NP434_20265	COG3962	Belongs to the TPP enzyme family
NP434_20270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP434_20280	COG1012	belongs to the aldehyde dehydrogenase family
NP434_20285	COG1349	DNA-binding transcription factor activity
NP434_20290	COG0667	Aldo Keto reductase
NP434_20305	COG2814	Major facilitator Superfamily
NP434_20310	COG0326	Molecular chaperone. Has ATPase activity
NP434_20320	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_20325	COG1309	transcriptional regulator
NP434_20330	COG1012	belongs to the aldehyde dehydrogenase family
NP434_20335	COG1714	RDD family
NP434_20340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP434_20350	COG1714	RDD family
NP434_20355	COG2311	Membrane
NP434_20360	COG1917	Cupin 2, conserved barrel domain protein
NP434_20365	COG1309	transcriptional regulator
NP434_20370	COG1028	Short-chain dehydrogenase reductase Sdr
NP434_20375	COG1846	Transcriptional regulator
NP434_20380	COG1380	Effector of murein hydrolase LrgA
NP434_20385	COG1346	cytolysis
NP434_20390	COG5039	Polysaccharide pyruvyl transferase
NP434_20395	COG1929	Belongs to the glycerate kinase type-1 family
NP434_20400	COG1802	Transcriptional regulator
NP434_20405	COG1070	Carbohydrate kinase
NP434_20410	COG2610	gluconate transmembrane transporter activity
NP434_20415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP434_20420	COG0450	alkyl hydroperoxide reductase
NP434_20425	COG3634	alkyl hydroperoxide reductase activity
NP434_20435	COG2723	6-phospho-beta-galactosidase activity
NP434_20440	COG2190	(PTS) system
NP434_20450	COG2188	Transcriptional regulator
NP434_20465	COG1131	(ABC) transporter
NP434_20470	COG1994	Peptidase M50
NP434_20475	COG0535	radical SAM domain protein
NP434_20485	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NP434_20500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NP434_20515	COG1063	alcohol dehydrogenase
NP434_20535	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NP434_20540	COG0456	acetyltransferase
NP434_20545	COG0457	Tetratricopeptide repeat
NP434_20555	COG0010	Belongs to the arginase family
NP434_20560	COG0833	amino acid
NP434_20565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP434_20570	COG3829	transcription factor binding
NP434_20575	COG5002	protein histidine kinase activity
NP434_20580	COG0745	RESPONSE REGULATOR receiver
NP434_20600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP434_20605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NP434_20610	COG4853	Protein conserved in bacteria
NP434_20615	COG4863	YycH protein
NP434_20620	COG5002	protein histidine kinase activity
NP434_20625	COG0745	RESPONSE REGULATOR receiver
NP434_20655	COG0346	lactoylglutathione lyase activity
NP434_20660	COG0305	Participates in initiation and elongation during chromosome replication
NP434_20675	COG3093	addiction module antidote protein HigA
NP434_20680	COG2807	transmembrane transport
NP434_20685	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP434_20690	COG0359	binds to the 23S rRNA
NP434_20695	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NP434_20700	COG4241	membrane
NP434_20710	COG5577	PFAM Coat F domain
NP434_20715	COG1733	regulation of RNA biosynthetic process
NP434_20720	COG1227	inorganic diphosphatase activity
NP434_20730	COG2271	Major facilitator Superfamily
NP434_20735	COG4978	Transcriptional regulator
NP434_20735	COG0789	Transcriptional regulator
NP434_20745	COG4319	ketosteroid isomerase
NP434_20750	COG1357	PFAM Pentapeptide repeats (8 copies)
NP434_20755	COG2814	Major facilitator Superfamily
NP434_20760	COG0583	DNA-binding transcription factor activity
NP434_20765	COG2153	protein acetylation
NP434_20780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP434_20785	COG1846	Transcriptional regulator
NP434_20790	COG2153	protein acetylation
NP434_20795	COG2364	Membrane
NP434_20800	COG0456	acetyltransferase
NP434_20805	COG2315	Protein conserved in bacteria
NP434_20810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP434_20820	COG2814	Major facilitator Superfamily
NP434_20825	COG1331	Highly conserved protein containing a thioredoxin domain
NP434_20830	COG0789	Transcriptional regulator
NP434_20835	COG0697	spore germination
NP434_20840	COG1331	Highly conserved protein containing a thioredoxin domain
NP434_20845	COG1266	CAAX protease self-immunity
NP434_20850	COG2814	Major facilitator Superfamily
NP434_20850	COG0477	Major facilitator Superfamily
NP434_20855	COG0110	maltose O-acetyltransferase activity
NP434_20860	COG0346	lactoylglutathione lyase activity
NP434_20865	COG1609	Transcriptional regulator
NP434_20870	COG0708	Exodeoxyribonuclease III
NP434_20875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NP434_20880	COG0629	single-stranded DNA binding
NP434_20885	COG0360	Binds together with S18 to 16S ribosomal RNA
NP434_20890	COG0012	GTP binding
NP434_20895	COG0243	molybdopterin cofactor binding
NP434_20900	COG4481	Protein conserved in bacteria
NP434_20905	COG3949	Membrane
NP434_20915	COG1475	DNA binding
NP434_20920	COG1192	Involved in chromosome partitioning
NP434_20930	COG1475	DNA binding
NP434_20935	COG0357	Ribosomal RNA small subunit methyltransferase G
NP434_20940	COG0445	tRNA wobble uridine modification
NP434_20945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NP434_20950	COG1847	R3H domain protein
NP434_20955	COG0706	membrane insertase activity
NP434_20960	COG0594	ribonuclease P activity