locus-tag class description CXF51_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CXF51_00015 ENOG410848D S4 domain protein YaaA CXF51_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CXF51_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CXF51_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CXF51_00110 ENOG4105VRS hydrolase family 18 CXF51_00120 ENOG4108Z6B deaminase CXF51_00205 ENOG4105X0R protein from nitrogen regulatory protein P-II CXF51_00210 ENOG4105XVJ Protein of unknown function (DUF327) CXF51_00215 ENOG4105FA2 dna polymerase iii CXF51_00220 ENOG4105MA4 psp1 domain protein CXF51_00225 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) CXF51_00235 ENOG4105VC4 domain protein CXF51_00275 ENOG4105XFA sporulation peptidase YabG CXF51_00280 ENOG4105W42 Veg protein CXF51_00285 ENOG4105XEW small acid-soluble spore protein CXF51_00290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CXF51_00300 ENOG4105KME endoribonuclease L-psp CXF51_00305 ENOG4105K4W Could be involved in septation (By similarity) CXF51_00315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CXF51_00320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CXF51_00325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CXF51_00340 ENOG4108M14 stage v sporulation protein t CXF51_00355 ENOG41082I2 s4 domain protein CXF51_00375 ENOG41060GV RNA binding s1 domain protein CXF51_00405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CXF51_00410 ENOG4108UGV hypoxanthine phosphoribosyltransferase CXF51_00425 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CXF51_00430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase CXF51_00435 ENOG4105C6T cysteine synthase CXF51_00440 ENOG4105CRQ synthase (Component I) CXF51_00445 ENOG4105DDQ anthranilate synthase CXF51_00450 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CXF51_00455 ENOG4105EEI dihydropteroate synthase CXF51_00460 ENOG4105KRF dihydroneopterin aldolase CXF51_00465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CXF51_00565 ENOG4108Z0C Uvrb UvrC protein CXF51_00570 ENOG41066A3 ATP guanido phosphotransferase CXF51_00585 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CXF51_00590 ENOG4105CTP PilT protein domain protein CXF51_00595 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CXF51_00605 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CXF51_00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CXF51_00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CXF51_00670 ENOG4108VZM 50s ribosomal protein L10 CXF51_00695 ENOG4105XPM ribosomal protein CXF51_00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CXF51_00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CXF51_00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CXF51_00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CXF51_00740 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CXF51_00750 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CXF51_00755 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CXF51_00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CXF51_00765 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CXF51_00770 ENOG41082SA 50s ribosomal protein l29 CXF51_00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CXF51_00780 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CXF51_00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CXF51_00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CXF51_00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CXF51_00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CXF51_00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CXF51_00820 ENOG4105VPB 50S ribosomal protein L30 CXF51_00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CXF51_00850 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CXF51_00860 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CXF51_00865 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CXF51_00870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CXF51_00875 ENOG4108ZT0 50S ribosomal protein l17 CXF51_00885 ENOG4108JJB ABC transporter CXF51_00895 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CXF51_00900 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CXF51_00905 ENOG4108UJD 30S ribosomal protein S9 CXF51_00925 ENOG4105D1F ATP-binding protein CXF51_00975 ENOG410635T phage-like element pbsx protein CXF51_00985 ENOG41067QW Transcriptional regulator CXF51_01040 ENOG4105CDU Replicative dna helicase CXF51_01050 ENOG4105QBX endodeoxyribonuclease RusA CXF51_01150 ENOG4105IG6 Phage terminase, large subunit CXF51_01160 ENOG4106CGH Phage Mu protein F like protein CXF51_01200 ENOG41060SN CXF51_01220 ENOG4105FR7 XkdM protein, phage-like element PBSX CXF51_01230 ENOG4105MTC XkdN-like protein CXF51_01260 ENOG4105MFU Protein of unknown function (DUF2634) CXF51_01270 ENOG410906S phage-like element pbsx protein xkdt CXF51_01310 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CXF51_01350 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CXF51_01370 ENOG41067QW Transcriptional regulator CXF51_01535 ENOG4105CHH sulfate transporter CXF51_01545 ENOG4108SA1 esterase CXF51_01595 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CXF51_01605 ENOG4105EWC Purine nucleoside phosphorylase CXF51_01635 ENOG4105EMN RNA polymerase sigma factor CXF51_01645 ENOG4105C8B TIGR00159 family CXF51_01650 ENOG4107U5W ybbr family CXF51_01655 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CXF51_01665 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CXF51_01685 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CXF51_01690 ENOG4108TWJ NADH dehydrogenase subunit 5 CXF51_01710 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CXF51_01715 ENOG4105WAB arsR family transcriptional regulator CXF51_01775 ENOG4106DDH Sporulation-specific SASP protein CXF51_01785 ENOG4108HWY Beta-lactamase CXF51_01790 ENOG4107E6A Cytochrome p-450 CXF51_01800 ENOG4107QTZ amino acid CXF51_01805 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CXF51_01810 ENOG4105CXY transporter CXF51_01830 ENOG4105DCM major facilitator superfamily CXF51_01840 ENOG4106AXJ AraC family transcriptional regulator CXF51_01845 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CXF51_01865 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CXF51_01915 ENOG4108X79 transcriptional regulator CXF51_01935 ENOG4108J5H Homocysteine s-methyltransferase CXF51_01950 ENOG4105CSV Glutaminase CXF51_01970 ENOG4105C26 Dehydrogenase CXF51_01980 ENOG4105EQX glucarate dehydratase CXF51_02055 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CXF51_02060 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CXF51_02065 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CXF51_02070 ENOG4107EPV Aminotransferase class V CXF51_02075 ENOG4105C0R drug resistance transporter emrb qaca subfamily CXF51_02100 ENOG41060AI SEC-C motif CXF51_02110 ENOG4107Y7X LytTR CXF51_02115 ENOG4108IUW ABC transporter CXF51_02155 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CXF51_02165 ENOG4105DSE periplasmic solute binding protein CXF51_02170 ENOG4105DIK (ABC) transporter CXF51_02185 ENOG4108N0M stress protein CXF51_02190 ENOG4106FN3 tellurium resistance protein CXF51_02215 ENOG41079KZ Major Facilitator Superfamily CXF51_02230 ENOG4108A65 Transcriptional regulator CXF51_02235 ENOG4108IJ7 Glycine betaine CXF51_02240 ENOG4107SQ8 Glycine betaine CXF51_02270 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CXF51_02305 ENOG4105EIG urea carboxylase-associated protein 1 CXF51_02310 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CXF51_02315 ENOG4105I1F Resistance protein CXF51_02325 ENOG41089UC methyltransferase, type 11 CXF51_02330 ENOG4105C5Q Transcriptional regulator CXF51_02335 ENOG4105I82 acetyl xylan esterase CXF51_02350 ENOG4105C26 Dehydrogenase CXF51_02360 ENOG4107YHD transcriptional regulator CXF51_02370 ENOG4108PJD permease CXF51_02390 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CXF51_02420 ENOG4105S7A ErfK ybiS ycfS ynhG family protein CXF51_02430 ENOG4105CKI cobalamin synthesis protein CXF51_02440 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein CXF51_02470 ENOG4105C8Q Methyl-accepting chemotaxis CXF51_02475 ENOG41080HJ 6-phospho 3-hexuloisomerase CXF51_02480 ENOG4108VA3 3-hexulose-6-phosphate synthase CXF51_02520 ENOG4105SX7 Transporter CXF51_02535 ENOG4105W8Z 4'-phosphopantetheinyl transferase CXF51_02550 ENOG4105CDA abc transporter atp-binding protein CXF51_02565 ENOG4106P55 Transcriptional regulator CXF51_02575 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CXF51_02580 ENOG41069ZX CXF51_02585 ENOG41069ZX CXF51_02630 ENOG4107WD8 ABC transporter, permease CXF51_02670 ENOG4105DHS permease protein CXF51_02680 ENOG4108IPW abc transporter atp-binding protein CXF51_02695 ENOG4105R8C Transcriptional regulator CXF51_02700 ENOG4108DBC nitroreductase CXF51_02705 ENOG41067V3 Antibiotic biosynthesis monooxygenase CXF51_02710 ENOG4105YVS arsR family transcriptional regulator CXF51_02740 ENOG4105KTB nuclear export factor GLE1 CXF51_02805 ENOG4105E7W lamb ycsf family protein CXF51_02815 ENOG4105CFM UPF0317 protein CXF51_02835 ENOG4105XJB lipolytic protein G-D-S-L family CXF51_02845 ENOG41061CK Antibiotic biosynthesis monooxygenase CXF51_02850 ENOG4107RVG penicillin-binding protein CXF51_02870 ENOG4105HMZ Methyltransferase CXF51_02875 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CXF51_02900 ENOG4105VCH membrane CXF51_02940 ENOG4105C0X amino acid CXF51_02965 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CXF51_02975 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) CXF51_02980 ENOG4105EU9 CXF51_02985 ENOG4105QVS general stress protein CXF51_02990 ENOG41082W1 Cupin 2, conserved barrel domain protein CXF51_03005 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CXF51_03010 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CXF51_03015 ENOG4108MRH transcriptional regulatory protein CXF51_03020 ENOG4107QJT sodium dicarboxylate symporter CXF51_03065 ENOG4105SZ6 Thioredoxin CXF51_03070 ENOG4105CPF Cell wall formation (By similarity) CXF51_03085 ENOG4105C1J atp-dependent rna helicase CXF51_03095 ENOG4105CKV Membrane CXF51_03105 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CXF51_03115 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CXF51_03125 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CXF51_03135 ENOG4105FUA antagonist CXF51_03140 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CXF51_03145 ENOG4107SGM protein serine threonine phosphatase CXF51_03150 ENOG4105WN5 stage II sporulation protein CXF51_03155 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CXF51_03165 ENOG41064BQ Phosphatase CXF51_03235 ENOG4105VZ8 Transcriptional regulator CXF51_03250 ENOG4105VEQ Cold shock protein CXF51_03255 ENOG4108VJ1 Transcriptional regulator (CarD family CXF51_03285 ENOG4107U9B transcriptional regulator CXF51_03290 ENOG4105DXI Major Facilitator superfamily CXF51_03305 ENOG4105GIG CXF51_03315 ENOG4105KRI phosphocarrier protein (HPr CXF51_03330 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CXF51_03335 ENOG4108ZMQ domain protein CXF51_03340 ENOG4105MJ9 esterase CXF51_03355 ENOG4105KVH Transcriptional regulator CXF51_03360 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CXF51_03365 ENOG4105EQ0 Major Facilitator superfamily CXF51_03370 ENOG4108JGH Tetr family transcriptional regulator CXF51_03375 ENOG41082YX Transcriptional regulator, arsr family CXF51_03380 ENOG4107R5R arsenical pump membrane protein CXF51_03390 ENOG4105Z7P Acetyltransferase (GNAT) family CXF51_03395 ENOG4107Y9U Membrane CXF51_03405 ENOG4108SQ9 flavin reductase domain protein, FMN-binding CXF51_03410 ENOG4108ZHR arsR family transcriptional regulator CXF51_03430 ENOG4105ENE Histidine kinase CXF51_03445 ENOG4108WC5 Alpha Beta Hydrolase Fold protein CXF51_03455 ENOG4108Z5V transcriptional regulator, merr family CXF51_03460 ENOG41076HS cation diffusion facilitator family transporter CXF51_03470 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CXF51_03475 ENOG4108VGI doxx family CXF51_03480 ENOG4105XXY Thioredoxin CXF51_03530 ENOG4105WQG acetyltransferase CXF51_03540 ENOG4105C85 amino acid CXF51_03550 ENOG41062A4 Transcriptional regulator CXF51_03560 ENOG4108TVJ Nitroreductase CXF51_03565 ENOG4105FS7 Transcriptional regulator CXF51_03580 ENOG4105DRR Transcriptional regulator, GntR family CXF51_03585 ENOG4105VRS hydrolase family 18 CXF51_03605 ENOG4108ZMX Domain of unknown function (DU1801) CXF51_03615 ENOG4108YM7 Gcn5-related n-acetyltransferase CXF51_03620 ENOG4107TVP HD domain protein CXF51_03625 ENOG41090UD (LipO)protein CXF51_03630 ENOG4105F27 Major Facilitator CXF51_03635 ENOG4105VZJ PTS System CXF51_03640 ENOG4105VCP PTS System CXF51_03650 ENOG4105CS2 ec 3.2.1.21 CXF51_03655 ENOG4108TZY GntR Family Transcriptional Regulator CXF51_03660 ENOG4105EVU fructokinase CXF51_03665 ENOG4105DG6 mannose-6-phosphate isomerase CXF51_03670 ENOG4105D3P Mannan endo-1,4-beta-mannosidase CXF51_03715 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CXF51_03720 ENOG4105K8N protein family UPF0079, ATPase CXF51_03730 ENOG410801F ribosomal-protein-alanine acetyltransferase CXF51_03735 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CXF51_03745 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CXF51_03755 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CXF51_03775 ENOG4108TYN CAAX amino terminal protease family protein CXF51_03780 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CXF51_03785 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CXF51_03795 ENOG410635T phage-like element pbsx protein CXF51_03850 ENOG4108NF7 phage-type endonuclease CXF51_03855 ENOG4108PNI recT protein CXF51_03945 ENOG4107KNS CXF51_04090 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CXF51_04125 ENOG4105CPQ Dehydrogenase CXF51_04140 ENOG41087YS Phage shock protein A CXF51_04150 ENOG4108WV1 Pfam:DUF477 CXF51_04195 ENOG4107YUH hydrolase CXF51_04225 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CXF51_04255 ENOG4105C7N Xanthine uracil vitamin C permease CXF51_04280 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CXF51_04285 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CXF51_04290 ENOG4105C83 adenylosuccinate lyase CXF51_04295 ENOG4105C8V SAICAR synthetase CXF51_04300 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CXF51_04305 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CXF51_04320 ENOG4105CXB phosphoribosylaminoimidazole synthetase CXF51_04325 ENOG4108V3E phosphoribosylglycinamide formyltransferase CXF51_04330 ENOG4105DC1 bifunctional purine biosynthesis protein purh CXF51_04335 ENOG4105C12 Phosphoribosylglycinamide synthetase CXF51_04365 ENOG4105KGF protein, YerC YecD CXF51_04395 ENOG4105CRN Aminoglycoside phosphotransferase CXF51_04410 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CXF51_04420 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CXF51_04425 ENOG4108IG5 Transcriptional regulator CXF51_04435 ENOG4105CBD Diacylglycerol kinase CXF51_04440 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CXF51_04510 ENOG4108HFV CXF51_04535 ENOG4105CDY transcriptional regulatory protein CXF51_04550 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein CXF51_04555 ENOG4107S9F NmrA family CXF51_04570 ENOG4105WEF catalase CXF51_04575 ENOG4105M18 -acetyltransferase CXF51_04590 ENOG4105C2F Histidine kinase CXF51_04640 ENOG4105CX8 fg-gap repeat protein CXF51_04645 ENOG4105CX8 fg-gap repeat protein CXF51_04665 ENOG4105E0S extracellular solute-binding protein family 1 CXF51_04675 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CXF51_04690 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CXF51_04695 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CXF51_04715 ENOG4106I4J membrane CXF51_04720 ENOG4108PCN EamA-like transporter family CXF51_04730 ENOG41061H0 Monooxygenase CXF51_04750 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CXF51_04785 ENOG41090R9 glycosyltransferase CXF51_04810 ENOG4105FKZ Methyl-accepting chemotaxis CXF51_04825 ENOG4107SWG transcriptional regulator MERR family CXF51_04865 ENOG4105E0A ABC, transporter CXF51_04870 ENOG4108U1V ABC transporter, permease CXF51_04880 ENOG4108HUF Transporter CXF51_04900 ENOG4108J20 pectate lyase CXF51_04940 ENOG410855V Acylphosphatase CXF51_04995 ENOG4105GEU Spore germination protein CXF51_05005 ENOG4108Q5U germination protein, ger(x)c family CXF51_05020 ENOG4105CG3 alpha amylase, catalytic region CXF51_05025 ENOG4107414 GntR family transcriptional regulator CXF51_05040 ENOG4107RKG DJ-1/PfpI family CXF51_05070 ENOG4108ISG Major Facilitator CXF51_05075 ENOG4105UPD Calcium Proton CXF51_05085 ENOG4105D8X mechanosensitive ion channel CXF51_05105 ENOG4106KE4 Dehydrogenase CXF51_05110 ENOG4105D7N magnesium and cobalt transport protein CorA CXF51_05120 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CXF51_05150 ENOG4107RUY (E1 component), alpha subunit CXF51_05175 ENOG41069DP small acid-soluble spore protein CXF51_05180 ENOG4105KK4 UPF0060 membrane protein CXF51_05210 ENOG4105F8D glycoside hydrolase family 4 CXF51_05215 ENOG4108Q3X Transcriptional regulator CXF51_05230 ENOG4105BZ1 (ABC) transporter CXF51_05240 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CXF51_05245 ENOG4105BZU Histidine kinase CXF51_05250 ENOG4105WH1 Two component transcriptional regulator luxr family CXF51_05255 ENOG4105CJ1 ABC, transporter CXF51_05265 ENOG4108KYE ABC-2 type transporter CXF51_05270 ENOG4105U3E Transcriptional regulator CXF51_05285 ENOG4105YA8 Transcriptional regulator CXF51_05295 ENOG4108YYS metal-dependent hydrolase (By similarity) CXF51_05305 ENOG410834F Transcriptional regulator CXF51_05315 ENOG4108MES Periplasmic binding protein CXF51_05320 ENOG4105DQ5 transport system permease protein CXF51_05325 ENOG4108IHU transport system permease protein CXF51_05335 ENOG4107Y03 Nitroreductase CXF51_05385 ENOG4106AKJ CXF51_05390 ENOG4105D74 hydrolase CXF51_05395 ENOG4105CKK Glycosyl transferase, family 2 CXF51_05410 ENOG4105CEN a g-specific adenine glycosylase CXF51_05415 ENOG4106BXE CXF51_05435 ENOG4105EVI UPF0374 protein CXF51_05455 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CXF51_05460 ENOG4105G5W regulator Fur family CXF51_05570 ENOG4108N23 SpoOM-related protein CXF51_05585 ENOG4105EC3 peptidase S51, dipeptidase E CXF51_05590 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CXF51_05620 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CXF51_05635 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CXF51_05645 ENOG4105VZ8 Transcriptional regulator CXF51_05670 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CXF51_05690 ENOG4105CYN Serine protein kinase CXF51_05705 ENOG4105CW7 secretion protein, HlyD family CXF51_05710 ENOG4105C0R drug resistance transporter emrb qaca subfamily CXF51_05715 ENOG4105CS1 NAD(P)H quinone oxidoreductase CXF51_05735 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CXF51_05740 ENOG4105CZV ABC transporter CXF51_05745 ENOG4105CJ1 ABC, transporter CXF51_05750 ENOG4108TU7 Inherit from COG: (ABC) transporter CXF51_05755 ENOG4105VEQ Cold shock protein CXF51_05815 ENOG4108YBP pseudouridine synthase CXF51_05825 ENOG41080XP Cbs domain CXF51_05830 ENOG4107YBY Hydrolase CXF51_05850 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CXF51_05860 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CXF51_05875 ENOG4105BZU Histidine kinase CXF51_05880 ENOG4105WH1 Two component transcriptional regulator luxr family CXF51_05915 ENOG4105ED1 spovr family CXF51_05920 ENOG4105G6Z alkaline phosphatase CXF51_05935 ENOG4105BZN citrate synthase CXF51_05940 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CXF51_05950 ENOG4105C8J )-transporter CXF51_05970 ENOG4105J37 CXF51_05975 ENOG4108AEY RNA polymerase sigma factor CXF51_05990 ENOG4105C37 (CBS) domain CXF51_06000 ENOG4105CHM Aminotransferase CXF51_06005 ENOG4105C37 (CBS) domain CXF51_06015 ENOG4105WMR Protein CrcB homolog CXF51_06020 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CXF51_06035 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CXF51_06040 ENOG4107VMI polysaccharide deacetylase CXF51_06045 ENOG4105F0I Aminotransferase CXF51_06065 ENOG4105BZ1 (ABC) transporter CXF51_06110 ENOG4105WZB UPF0342 protein CXF51_06130 ENOG4107S91 Sodium hydrogen exchanger CXF51_06135 ENOG4105NCW Trka-c domain protein CXF51_06160 ENOG4105RHA ABC transporter, permease CXF51_06175 ENOG4105EQI Metal Dependent Phosphohydrolase CXF51_06230 ENOG4105NBU tryptophan transport protein CXF51_06235 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CXF51_06240 ENOG4105K59 histidine triad (HIT) protein CXF51_06275 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CXF51_06290 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CXF51_06295 ENOG4105C1Q protoporphyrinogen oxidase CXF51_06325 ENOG4105DER m42 family CXF51_06340 ENOG4106AXD CXF51_06345 ENOG4108RQ5 Beta-lactamase domain-containing protein CXF51_06380 ENOG4105KD7 acetyltransferase CXF51_06390 ENOG4108HUF Transporter CXF51_06395 ENOG4107TB6 phosphoglycerate mutase CXF51_06405 ENOG4107F3J Amp-dependent synthetase and ligase CXF51_06415 ENOG4106YBV Methyl-accepting chemotaxis CXF51_06435 ENOG4105XVF Competence transcription factor CXF51_06440 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CXF51_06445 ENOG4105X3H Excalibur domain protein CXF51_06450 ENOG4105E1V na solute symporter CXF51_06460 ENOG41060YP CXF51_06480 ENOG4108INS Transcriptional regulator CXF51_06515 ENOG4106K7D Major facilitator family transporter CXF51_06525 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding CXF51_06635 ENOG4105UQX Mate efflux family protein CXF51_06640 ENOG4106HBX Transcriptional Regulator AraC Family CXF51_06655 ENOG4105SF0 DinB family CXF51_06660 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CXF51_06670 ENOG4105MYW Pentapeptide repeat protein CXF51_06680 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CXF51_06690 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CXF51_06695 ENOG4108N5B 2-phosphosulfolactate phosphatase CXF51_06710 ENOG4105DIA mandelate racemase muconate lactonizing CXF51_06740 ENOG4105QNR S1 RNA binding domain protein CXF51_06760 ENOG4105K7K Transcriptional regulator CXF51_06775 ENOG4105D4Y metalloprotease CXF51_06785 ENOG4107AYK membrAne CXF51_06795 ENOG41073B9 CXF51_06800 ENOG4108KP7 hydrolase CXF51_06805 ENOG4108MXZ Esterase CXF51_06810 ENOG4105VG1 fes assembly suf system protein CXF51_06860 ENOG4105DBV ornithine carbamoyltransferase CXF51_06900 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CXF51_06915 ENOG4105C3U ABC transporter CXF51_06920 ENOG4108JQ7 (ABC) transporter CXF51_06935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CXF51_06960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CXF51_06970 ENOG4108JQ7 (ABC) transporter CXF51_06985 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CXF51_06990 ENOG4108ZCF integral membrane protein CXF51_07005 ENOG4105DPN Oligoendopeptidase f CXF51_07030 ENOG4108Z18 K06886 hemoglobin CXF51_07040 ENOG4105MIX Adenylate cyclase CXF51_07055 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CXF51_07075 ENOG4105ETU transcriptional activator (TenA CXF51_07080 ENOG4108VEU Thiamine monophosphate synthase CXF51_07095 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CXF51_07100 ENOG4105D06 uba thif-type nad fad binding protein CXF51_07105 ENOG4105DWF phosphomethylpyrimidine kinase CXF51_07110 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CXF51_07115 ENOG4107A88 CXF51_07180 ENOG4108ZMI UPF0477 protein CXF51_07190 ENOG4105C28 cystathionine CXF51_07195 ENOG4105C28 cystathionine CXF51_07200 ENOG4105D9U N-acetyltransferase CXF51_07280 ENOG4106ANW SMI1_KNR4 CXF51_07350 ENOG4105DG6 mannose-6-phosphate isomerase CXF51_07355 ENOG4105G7B Protein of unknown function (DUF2992) CXF51_07370 ENOG4108Z66 YbaK ebsC protein CXF51_07405 ENOG4107CUJ Protein of unknown function (DUF2690) CXF51_07430 ENOG4108IEG Formate dehydrogenase Alpha subunit CXF51_07475 ENOG4105C4B ABC transporter, permease CXF51_07480 ENOG4108IXI (ABC) transporter CXF51_07490 ENOG4105Q95 Cupin 2, conserved barrel domain protein CXF51_07505 ENOG4105D2H Uronic isomerase CXF51_07525 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CXF51_07530 ENOG4105DMW Dehydrogenase reductase CXF51_07555 ENOG4107TSN permease CXF51_07580 ENOG41068K0 YCII-related domain CXF51_07585 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CXF51_07590 ENOG4105KWG Pfam:DUF1696 CXF51_07595 ENOG4105K7W phage-related replication protein CXF51_07605 ENOG410635T phage-like element pbsx protein CXF51_07680 ENOG41060SN CXF51_07700 ENOG4105FR7 XkdM protein, phage-like element PBSX CXF51_07705 ENOG4105MTC XkdN-like protein CXF51_07740 ENOG41066EA baseplate J family protein CXF51_07745 ENOG410906S phage-like element pbsx protein xkdt CXF51_07800 ENOG4105CJ3 phosphate transporter CXF51_07805 ENOG4107GRR phosphate transport regulator CXF51_07845 ENOG4108ME1 Peptidase M55 D-aminopeptidase CXF51_07870 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CXF51_07885 ENOG4108JQ7 (ABC) transporter CXF51_07900 ENOG4108S4H thioesterase Superfamily protein CXF51_07905 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CXF51_07925 ENOG4108428 Inherit from COG: -acetyltransferase CXF51_07935 ENOG41080TC multidrug resistance protein CXF51_07940 ENOG4105CIY formyltetrahydrofolate deformylase CXF51_07945 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CXF51_07960 ENOG4105K56 Transcriptional regulator CXF51_07965 ENOG4108ZHJ Organic hydroperoxide resistance protein CXF51_07970 ENOG4107Y2X deaminase CXF51_07980 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CXF51_07990 ENOG4108W7F transporter, permease CXF51_08000 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CXF51_08015 ENOG41062D9 Histidine kinase CXF51_08025 ENOG4106849 propeptide, pepSY amd peptidase M4 CXF51_08040 ENOG4105CJW magnesium transporter CXF51_08105 ENOG4107T5V SNARE associated Golgi CXF51_08115 ENOG4108WZW RNA polymerase sigma CXF51_08125 ENOG410681C small acid-soluble spore protein CXF51_08135 ENOG4105D0M Protease HtpX homolog CXF51_08155 ENOG4108TGC Acyltransferase CXF51_08165 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CXF51_08170 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CXF51_08175 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CXF51_08200 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CXF51_08230 ENOG41090MY MarR family Transcriptional regulator CXF51_08235 ENOG4105E14 MotA TolQ exbB proton channel CXF51_08255 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase CXF51_08265 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CXF51_08275 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CXF51_08330 ENOG4105C59 p-type ATPase CXF51_08350 ENOG4105CID antiterminator CXF51_08360 ENOG4105KRI phosphocarrier protein (HPr CXF51_08365 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CXF51_08390 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CXF51_08395 ENOG4105K4I Scp-like extracellular CXF51_08420 ENOG4107R88 Chemotaxis protein (CheV) CXF51_08435 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CXF51_08455 ENOG4107IN1 Protein of unknown function (DUF1797) CXF51_08490 ENOG4105NQC Flavodoxin CXF51_08500 ENOG4105CH2 amidohydrolase CXF51_08515 ENOG4105D3R alkyl hydroperoxide reductase CXF51_08520 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CXF51_08535 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CXF51_08545 ENOG4105CVM Molybdenum cofactor synthesis domain protein CXF51_08550 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CXF51_08555 ENOG4108ZAF Molybdopterin CXF51_08560 ENOG41067WU Molybdopterin converting factor (Subunit 1) CXF51_08580 ENOG4107X8C Efflux transporter RND family MFP subunit CXF51_08585 ENOG4105C19 ABC transporter CXF51_08595 ENOG4105E98 transcriptional regulator DeoR family CXF51_08625 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CXF51_08660 ENOG4107ZYR domain protein CXF51_08670 ENOG4105CN5 Metallo-Beta-Lactamase CXF51_08685 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CXF51_08705 ENOG4105CPP Dehydrogenase, E1 component CXF51_08735 ENOG4105WBI UPF0223 protein CXF51_08800 ENOG4105CI3 gtp-binding protein typa CXF51_08805 ENOG4105QA2 CXF51_08835 ENOG4105ZPI UPF0358 protein CXF51_08855 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CXF51_08870 ENOG4105CCU oxidase (Subunit III) CXF51_08890 ENOG41080XQ Signal transduction protein with cbs domains CXF51_08920 ENOG4105WUC UPF0298 protein CXF51_08925 ENOG4106H78 methyltransferase CXF51_08940 ENOG4105D78 K07001 NTE family protein CXF51_08945 ENOG41063PX domain protein CXF51_08960 ENOG4105KNH Nucleic acid-binding protein CXF51_08965 ENOG41067VY 50S ribosomal protein L32 CXF51_08990 ENOG4108V6E Cell division protein mraZ CXF51_08995 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CXF51_09005 ENOG4105CJN penicillin-binding protein CXF51_09015 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CXF51_09025 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CXF51_09050 ENOG4108R2U division initiation protein CXF51_09060 ENOG4105K67 small basic protein CXF51_09070 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CXF51_09105 ENOG4105WR5 sporulation protein, YlmC YmxH family CXF51_09110 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CXF51_09115 ENOG4105DFA alanine racemase domain protein CXF51_09125 ENOG41067XK integral membrane protein CXF51_09140 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CXF51_09150 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CXF51_09155 ENOG4105C34 Pseudouridine synthase CXF51_09160 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CXF51_09170 ENOG4105CXT aspartate transcarbamylase CXF51_09180 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CXF51_09190 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CXF51_09200 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CXF51_09205 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CXF51_09210 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CXF51_09225 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CXF51_09235 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CXF51_09255 ENOG4105DSJ YicC domain protein CXF51_09260 ENOG4105KC4 UPF0296 protein CXF51_09265 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CXF51_09275 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CXF51_09280 ENOG4105C25 Primosomal protein n' CXF51_09285 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CXF51_09290 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CXF51_09300 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CXF51_09315 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CXF51_09320 ENOG4105DJV ribulose-phosphate 3-epimerase CXF51_09325 ENOG4105FJ0 thiamine CXF51_09335 ENOG4105VB9 50S ribosomal protein l28 CXF51_09340 ENOG4108ZAA Alkaline-shock protein CXF51_09345 ENOG4105DP4 dak2 domain fusion protein ylov CXF51_09355 ENOG4105EJQ L-serine dehydratase CXF51_09360 ENOG4105CB5 ATP-dependent DNA helicase recG CXF51_09365 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CXF51_09375 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CXF51_09380 ENOG4105CHR reductase CXF51_09385 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CXF51_09400 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CXF51_09410 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CXF51_09425 ENOG4108BW8 UPF0109 protein CXF51_09435 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CXF51_09440 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CXF51_09445 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CXF51_09450 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CXF51_09470 ENOG4105CMV Succinyl-CoA synthetase subunit beta CXF51_09480 ENOG4105C79 DNA protecting protein DprA CXF51_09500 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CXF51_09505 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CXF51_09515 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CXF51_09520 ENOG4108ZC9 flagellar basal-body rod protein flgc CXF51_09525 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CXF51_09530 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CXF51_09535 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CXF51_09550 ENOG4106YF4 Flagellar biosynthesis chaperone CXF51_09560 ENOG410696Y Flagellar hook-length control protein CXF51_09565 ENOG410822I Flagellar hook capping protein CXF51_09570 ENOG4108JQA flagellar CXF51_09575 ENOG41068WV flagellar FlbD family protein CXF51_09585 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CXF51_09590 ENOG4105DD5 Flagellar motor switch protein CXF51_09595 ENOG4107YTP response regulator receiver protein CXF51_09610 ENOG4105VS8 Flagellar biosynthetic protein fliq CXF51_09615 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CXF51_09640 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CXF51_09645 ENOG4105CBS Chea signal transduction histidine kinase CXF51_09650 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis CXF51_09665 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CXF51_09675 ENOG4105CE9 30S ribosomal protein S2 CXF51_09695 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CXF51_09715 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CXF51_09730 ENOG4105CHV Transcription elongation factor NusA CXF51_09735 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CXF51_09740 ENOG4105VHM ribosomal protein CXF51_09750 ENOG4105W7A Protein of unknown function (DUF503) CXF51_09755 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CXF51_09770 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CXF51_09825 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CXF51_09835 ENOG4105CNU cell division protein FtsK CXF51_09860 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CXF51_09865 ENOG4105XZV Protein of unknown function (DUF3243) CXF51_09880 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CXF51_09895 ENOG4108A04 Beta-lactamase CXF51_09910 ENOG4105MCT stage V sporulation protein S CXF51_09945 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CXF51_09955 ENOG4105IIP Membrane CXF51_09960 ENOG4105W1N transcriptional regulator CXF51_09965 ENOG4108151 Beta-lactamase domain protein CXF51_09975 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CXF51_09985 ENOG4107QKG PfaD family CXF51_09990 ENOG41062T2 Acyl carrier protein CXF51_09995 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase CXF51_10005 ENOG4108MGH Enoyl-CoA hydratase CXF51_10040 ENOG4106A3M Cytochrome p-450 CXF51_10075 ENOG410814C multidrug resistance protein CXF51_10095 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CXF51_10100 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CXF51_10115 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CXF51_10125 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CXF51_10130 ENOG4105U6W MutT NUDIX family protein CXF51_10135 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CXF51_10335 ENOG41068G1 CXF51_10475 ENOG4108NE4 CXF51_10495 ENOG4107NTZ CXF51_10625 ENOG4108ZUE Phage regulatory protein rha CXF51_10705 ENOG4108J9Q DNA ligase CXF51_10710 ENOG4108RAV Conserved protein CXF51_10765 ENOG41088HM CXF51_10945 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CXF51_10950 ENOG4106ITI Glutaredoxin CXF51_10960 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CXF51_10990 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CXF51_11050 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CXF51_11070 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CXF51_11075 ENOG4105CXI aluminum resistance protein CXF51_11080 ENOG4105KV4 Transcriptional regulator CXF51_11085 ENOG4105C5F glutamine synthetase CXF51_11090 ENOG41079P0 CXF51_11160 ENOG4107NTZ CXF51_11185 ENOG4105DSG hydrolase family 43 CXF51_11195 ENOG4105C93 Xylose Isomerase CXF51_11210 ENOG4107Y9E nuclease CXF51_11215 ENOG4105C54 Major Facilitator superfamily CXF51_11230 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CXF51_11305 ENOG4108Q8B Spore germination protein CXF51_11325 ENOG4105FVX CXF51_11340 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) CXF51_11360 ENOG4105VPS UPF0291 protein CXF51_11375 ENOG4105VXM UPF0154 protein CXF51_11385 ENOG4107QIV Cytochrome c biogenesis protein CXF51_11410 ENOG4107DZX Small, acid-soluble spore protein P CXF51_11425 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CXF51_11450 ENOG4105MI2 CXF51_11455 ENOG4105W8X HesB YadR YfhF-family protein CXF51_11460 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CXF51_11465 ENOG4105K4P CoA-binding domain protein CXF51_11500 ENOG4108MYR Secreted protein CXF51_11515 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CXF51_11530 ENOG4107QX3 carboxylase CXF51_11555 ENOG4105CEY Amp-dependent synthetase and ligase CXF51_11575 ENOG4106U2H Protein of unknown function (DUF1360) CXF51_11640 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CXF51_11645 ENOG4105SKE transcriptional Regulator LysR family CXF51_11655 ENOG4105BZ8 glutamate synthase CXF51_11665 ENOG4105C5Q Transcriptional regulator CXF51_11675 ENOG4105II7 pyrroline-5-carboxylate reductase CXF51_11700 ENOG41068WN CXF51_11715 ENOG4105IE8 Alpha-ketoglutarate permease CXF51_11755 ENOG4105EC8 Methyl-accepting chemotaxis CXF51_11765 ENOG4108YQE rare lipoprotein a CXF51_11770 ENOG4105XPP Protein of unknown function (DUF1275) CXF51_11780 ENOG4108RAV Conserved protein CXF51_11800 ENOG4105EPI acetyltransferase, (GNAT) family CXF51_11820 ENOG41073R8 VanW family CXF51_11830 ENOG4105VMP Transcriptional regulator CXF51_11855 ENOG4108V4B ThiJ pfpI CXF51_11860 ENOG4108J4B Beta-lactamase CXF51_11895 ENOG4105YB8 TM2 domain containing protein CXF51_11900 ENOG4108IMY Transcriptional regulator CXF51_11975 ENOG4108J9Q DNA ligase CXF51_12040 ENOG410780I phosphoprotein phosphatase activity CXF51_12050 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CXF51_12055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CXF51_12095 ENOG4108Z7R Chaperone CsaA CXF51_12100 ENOG4105FTV AraC Family Transcriptional Regulator CXF51_12105 ENOG4108HJF gCN5-related N-acetyltransferase CXF51_12125 ENOG4105D29 Helix-turn-helix type 11 domain protein CXF51_12135 ENOG4105KTU Transcriptional regulator, arsr family CXF51_12165 ENOG4105ECK Fatty Acid Desaturase CXF51_12175 ENOG4108S01 response regulator CXF51_12185 ENOG41069ER domain protein CXF51_12190 ENOG4105C9U ATP-dependent DNA helicase RecQ CXF51_12210 ENOG4105SCY DNAK suppressor CXF51_12265 ENOG4105C8J )-transporter CXF51_12270 ENOG4105C09 Bile acid CXF51_12275 ENOG4105C7S Dehydrogenase CXF51_12290 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CXF51_12300 ENOG4105K4H Nlp p60 protein CXF51_12360 ENOG41090U3 tautomerase CXF51_12375 ENOG4105FBA Phospholipase Carboxylesterase CXF51_12390 ENOG4105E1V na solute symporter CXF51_12410 ENOG4108VXD carboxy-peptidase CXF51_12425 ENOG4106Z5R CXF51_12430 ENOG410841Q phosphoesterase PA-phosphatase related protein CXF51_12465 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CXF51_12470 ENOG4108TSC N-acetyltransferase CXF51_12490 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CXF51_12525 ENOG4107T32 3-phytase (EC 3.1.3.8) CXF51_12535 ENOG4105E0X reductase CXF51_12540 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CXF51_12565 ENOG41090WU lipolytic protein G-D-S-L family CXF51_12570 ENOG4108KF3 Electron transport protein SCO1 SenC CXF51_12590 ENOG4108UT2 hemolysin iii CXF51_12600 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CXF51_12605 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CXF51_12620 ENOG4107YX5 Pfam:DUF548 CXF51_12625 ENOG4108Y6J UPF0403 protein CXF51_12645 ENOG4108V06 Glutathione peroxidase CXF51_12650 ENOG4105CVG Homoserine O-transsuccinylase CXF51_12730 ENOG41065KQ synthase CXF51_12735 ENOG4105C2W permease CXF51_12750 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) CXF51_12760 ENOG4105D7K pfkb domain protein CXF51_12775 ENOG4105CHR reductase CXF51_12780 ENOG4105DVT helicase CXF51_12895 ENOG4105C5S asparaginyl-tRNA synthetase CXF51_12900 ENOG4105CHM Aminotransferase CXF51_12910 ENOG4105YAC CXF51_12920 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CXF51_12925 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CXF51_12930 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CXF51_12935 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CXF51_12940 ENOG4105DJ0 Poly(A) Polymerase CXF51_12955 ENOG4108Z5K methylglyoxal synthase CXF51_12960 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CXF51_12965 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CXF51_12990 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CXF51_13010 ENOG41068YB TPR repeat-containing protein CXF51_13015 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CXF51_13060 ENOG4105KHN chorismate mutase CXF51_13070 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CXF51_13080 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CXF51_13085 ENOG4105EAH synthase CXF51_13090 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CXF51_13095 ENOG4105XXQ heptaprenyl diphosphate synthase component I CXF51_13105 ENOG4105EUJ GTP cyclohydrolase i CXF51_13110 ENOG4105K70 DNA-binding protein CXF51_13115 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CXF51_13165 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CXF51_13170 ENOG4105CAT Cytidine monophosphate kinase CXF51_13185 ENOG4105MSI germination protein ypeb CXF51_13195 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) CXF51_13235 ENOG4105C9U ATP-dependent DNA helicase RecQ CXF51_13240 ENOG4105T7X CXF51_13260 ENOG4105FF2 Type I DHQase CXF51_13300 ENOG4105FE9 pseudouridine synthase CXF51_13330 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CXF51_13345 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CXF51_13355 ENOG4108R6K riboflavin synthase, subunit alpha CXF51_13370 ENOG4105C3F Signal peptidase i CXF51_13380 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) CXF51_13405 ENOG4107ZE5 PPIases accelerate the folding of proteins CXF51_13410 ENOG4105PTM secreted protein CXF51_13415 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CXF51_13425 ENOG4105G6R Stage v sporulation protein ae CXF51_13440 ENOG41090VF Stage v sporulation protein ac CXF51_13455 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CXF51_13460 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CXF51_13465 ENOG41082AN stage II sporulation protein CXF51_13475 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CXF51_13480 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CXF51_13495 ENOG4105I3K Ferric uptake regulator, Fur family CXF51_13500 ENOG4105MZ9 stage II sporulation protein m CXF51_13515 ENOG4105DFD Na H antiporter CXF51_13520 ENOG4108IJ0 Aspartate ammonia-lyase CXF51_13530 ENOG4108IMY Transcriptional regulator CXF51_13570 ENOG4105RHY Pfam:UPF0157 CXF51_13575 ENOG4105KAC Antibiotic biosynthesis monooxygenase CXF51_13590 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CXF51_13610 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase CXF51_13630 ENOG41069FQ Metallo-beta-lactamase superfamily CXF51_13635 ENOG4105II7 pyrroline-5-carboxylate reductase CXF51_13645 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CXF51_13655 ENOG410861F 50S ribosomal protein L33 CXF51_13660 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CXF51_13665 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CXF51_13670 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CXF51_13685 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) CXF51_13715 ENOG4105C0W non-ribosomal peptide synthetase CXF51_13725 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CXF51_13735 ENOG4105CHR reductase CXF51_13755 ENOG4108NA0 Uncharacterized conserved protein (COG2071) CXF51_13760 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CXF51_13770 ENOG4108ZVT methylmalonyl-coA epimerase CXF51_13775 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CXF51_13780 ENOG4108QEG Membrane CXF51_13790 ENOG4105E5Q amino acid AbC transporter CXF51_13800 ENOG4108Y6J UPF0403 protein CXF51_13805 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CXF51_13820 ENOG4105C7S Dehydrogenase CXF51_13845 ENOG4107RDP Dehydrogenase CXF51_13860 ENOG4106CCJ Protein of unknown function (DUF2627) CXF51_13865 ENOG4105CR4 methylisocitrate lyase CXF51_13885 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CXF51_13900 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CXF51_13910 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CXF51_13915 ENOG4107QQR Sporulation CXF51_13930 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CXF51_13945 ENOG4105CTB Polyprenyl synthetase CXF51_13950 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CXF51_13960 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CXF51_13965 ENOG4105M7K Involved in the transcription termination process (By similarity) CXF51_13970 ENOG4108ZSR alkaline shock protein CXF51_14010 ENOG4108CQH stage III sporulation protein AC CXF51_14015 ENOG4105KR5 Stage iii sporulation protein CXF51_14030 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CXF51_14035 ENOG4105DC7 peptidase M24 CXF51_14040 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CXF51_14050 ENOG4105CBJ Metal-dependent enzyme CXF51_14070 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CXF51_14075 ENOG4105WZW rhodanese family CXF51_14080 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CXF51_14110 ENOG4108IMY Transcriptional regulator CXF51_14175 ENOG41080XP Cbs domain CXF51_14185 ENOG4105C37 (CBS) domain CXF51_14250 ENOG4107ZXI Rhomboid family CXF51_14260 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CXF51_14265 ENOG4105WDJ 50S ribosomal protein L33 CXF51_14285 ENOG41068DG YceG-like family CXF51_14295 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CXF51_14300 ENOG4105E2Z phosphate ABC transporter (Permease CXF51_14305 ENOG4105C8U phosphate abc transporter CXF51_14325 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CXF51_14345 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CXF51_14350 ENOG41063Y9 CXF51_14355 ENOG4108U5J '-nucleotidase CXF51_14360 ENOG4105N80 Ferric uptake regulator, Fur family CXF51_14365 ENOG4108JYZ YitT family CXF51_14370 ENOG41069ZM Protein of unknown function (DUF2624) CXF51_14390 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CXF51_14415 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CXF51_14425 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 CXF51_14440 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CXF51_14460 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CXF51_14465 ENOG4105KG3 cytidine deaminase CXF51_14470 ENOG4107YR5 Diacylglycerol kinase CXF51_14475 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CXF51_14485 ENOG4105C9A Phoh family CXF51_14505 ENOG4105DI5 UPF0365 protein CXF51_14510 ENOG4105F7J membrane-bound serine protease CXF51_14530 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CXF51_14535 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CXF51_14550 ENOG4105CFG Acts as a chaperone (By similarity) CXF51_14555 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CXF51_14565 ENOG4105CSA Coproporphyrinogen iii oxidase CXF51_14610 ENOG4108UK2 deaminase CXF51_14625 ENOG4108D32 Methyltransferase CXF51_14635 ENOG4108WF2 Metal Dependent Phosphohydrolase CXF51_14640 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CXF51_14645 ENOG410812S Rna-binding protein CXF51_14660 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CXF51_14675 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CXF51_14680 ENOG41080BT SNARE associated Golgi CXF51_14695 ENOG4105WFK nuclease CXF51_14715 ENOG4108UXE Protein tyrosine phosphatase CXF51_14725 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CXF51_14730 ENOG41085FC arsR family transcriptional regulator CXF51_14760 ENOG41064HX Suppressor of fused protein (SUFU) CXF51_14775 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CXF51_14810 ENOG410906S phage-like element pbsx protein xkdt CXF51_14815 ENOG41066EA baseplate J family protein CXF51_14820 ENOG4105MFU Protein of unknown function (DUF2634) CXF51_14830 ENOG4105X7F CXF51_14835 ENOG4108WZM domain protein CXF51_14850 ENOG4105MTC XkdN-like protein CXF51_14865 ENOG4105FR7 XkdM protein, phage-like element PBSX CXF51_14885 ENOG41060SN CXF51_14930 ENOG4105IG6 Phage terminase, large subunit CXF51_14950 ENOG4106129 CXF51_14985 ENOG4108NF7 phage-type endonuclease CXF51_15015 ENOG41067QW Transcriptional regulator CXF51_15025 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CXF51_15045 ENOG4105C3S Mate efflux family protein CXF51_15055 ENOG41087NI Sulfite exporter TauE/SafE CXF51_15060 ENOG4105VFE sira family CXF51_15065 ENOG4107TPS domain protein CXF51_15085 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CXF51_15105 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein CXF51_15120 ENOG41090E6 transcriptional regulator MERR family CXF51_15150 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family CXF51_15160 ENOG4105PGM cation diffusion facilitator family transporter CXF51_15165 ENOG41090U3 tautomerase CXF51_15185 ENOG4105KMT branched-chain amino acid CXF51_15190 ENOG4108UMN azlc family CXF51_15195 ENOG4108ZRZ Transcriptional regulator (AsnC family) CXF51_15250 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CXF51_15265 ENOG4108MEK Metal-binding protein YodA CXF51_15270 ENOG410904A RNA polymerase CXF51_15290 ENOG4105C7F AcnD-accessory protein PrpF CXF51_15295 ENOG41083Q9 chitosanase CXF51_15305 ENOG4108VQT Alpha beta hydrolase fold protein CXF51_15315 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein CXF51_15330 ENOG4105PGS Spore coat protein CXF51_15385 ENOG4108IQ3 PTS system CXF51_15410 ENOG4108NGU Transcriptional regulator CXF51_15465 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CXF51_15485 ENOG4105C28 cystathionine CXF51_15500 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CXF51_15520 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CXF51_15525 ENOG4105DBI uridine monophosphokinase CXF51_15535 ENOG4105XYU peptidase (U32 family) CXF51_15550 ENOG4105VPH UPF0473 protein CXF51_15555 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CXF51_15560 ENOG4105VBH UPF0297 protein CXF51_15565 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CXF51_15575 ENOG4105C02 permease CXF51_15580 ENOG4105CDA abc transporter atp-binding protein CXF51_15585 ENOG4105CT1 (ABC) transporter CXF51_15595 ENOG4105DRP amino acid AbC transporter CXF51_15605 ENOG41060CR CXF51_15640 ENOG4105D1H recombination factor protein RarA CXF51_15645 ENOG4105CUZ uba thif-type nad fad binding protein CXF51_15655 ENOG4105C9M aspartyl-trna synthetase CXF51_15660 ENOG4105CUT histidyl-tRNA synthetase CXF51_15670 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CXF51_15680 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CXF51_15685 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CXF51_15690 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CXF51_15695 ENOG41067VP Protein of unknown function (DUF1049) CXF51_15700 ENOG4105NCW Trka-c domain protein CXF51_15720 ENOG4108QG2 Membrane CXF51_15725 ENOG4105NAP CXF51_15730 ENOG4105VIE preprotein translocase, subunit YajC CXF51_15735 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CXF51_15740 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CXF51_15745 ENOG41061AI Protein of unknown function (DUF2905) CXF51_15750 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CXF51_15755 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CXF51_15770 ENOG4105CK5 oxidoreductase CXF51_15800 ENOG4105CDY transcriptional regulatory protein CXF51_15815 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CXF51_15825 ENOG4108IYU L-aspartate oxidase CXF51_15840 ENOG4105CQC Prephenate dehydratase CXF51_15865 ENOG4105X36 (ribosomal) protein CXF51_15870 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CXF51_15885 ENOG4107QMS site-determining protein CXF51_15895 ENOG4105YHC Rod shape-determining protein MreD CXF51_15900 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CXF51_15910 ENOG4105W5Q DNA repair protein (RadC CXF51_15960 ENOG4105D52 delta-aminolevulinic acid dehydratase CXF51_15970 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CXF51_15990 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CXF51_16000 ENOG4108IUQ atp-dependent protease CXF51_16005 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CXF51_16010 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CXF51_16020 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CXF51_16030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CXF51_16045 ENOG4108ZP8 Acetolactate synthase small subunit CXF51_16060 ENOG4105I4A GCN5-related N-acetyltransferase CXF51_16075 ENOG4105M59 Phosphodiesterase, mj0936 family CXF51_16080 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CXF51_16085 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CXF51_16090 ENOG4108XJQ germination protein CXF51_16095 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CXF51_16100 ENOG41067TZ transcriptional regulator, MarR family CXF51_16105 ENOG4105PFC Transcriptional regulator CXF51_16115 ENOG4105E33 succinate dehydrogenase CXF51_16125 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CXF51_16135 ENOG4105CFH Aspartokinase CXF51_16150 ENOG4105K63 Thioredoxin CXF51_16165 ENOG4105C10 Electron transfer flavoprotein CXF51_16170 ENOG4105BZJ Electron transfer flavoprotein CXF51_16180 ENOG4107Z3H Transcriptional regulator, TetR family CXF51_16215 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CXF51_16235 ENOG4108RWN rrna methyltransferase CXF51_16240 ENOG41067MF small acid-soluble spore protein CXF51_16295 ENOG4108MDK Dehydrogenase CXF51_16310 ENOG4105EF1 ribulokinase CXF51_16320 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase CXF51_16335 ENOG410696E Membrane CXF51_16340 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CXF51_16345 ENOG4105VJV 50s ribosomal protein L35 CXF51_16350 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CXF51_16380 ENOG4105U0R haloacid dehalogenase-like hydrolase CXF51_16385 ENOG4105C22 threonyL-tRNA synthetase CXF51_16390 ENOG4108TDW sporulation protein YtxC CXF51_16415 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CXF51_16430 ENOG4105F27 Major Facilitator CXF51_16435 ENOG4105CV8 reductase CXF51_16440 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CXF51_16455 ENOG4105C2M dna polymerase I CXF51_16460 ENOG4105BZU Histidine kinase CXF51_16465 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CXF51_16475 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CXF51_16480 ENOG4108HMX isocitrate dehydrogenase (NADP) CXF51_16500 ENOG4105FS0 cytoplasmic membrane protein CXF51_16505 ENOG4105CA9 Pyruvate kinase CXF51_16510 ENOG4105CTQ phosphohexokinase CXF51_16525 ENOG4105C6K Malic enzyme CXF51_16535 ENOG4105VV2 CXF51_16545 ENOG4106EVM CXF51_16550 ENOG4105SFS phosphoesterase RecJ domain protein CXF51_16565 ENOG410635A Membrane CXF51_16625 ENOG4108KSA LysR family transcriptional regulator CXF51_16630 ENOG4105E8R UPF0173 metal-dependent hydrolase CXF51_16645 ENOG4105CH7 arginosuccinase CXF51_16655 ENOG4105EPU Molybdenum cofactor synthesis domain protein CXF51_16675 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CXF51_16690 ENOG4105VK3 rdd domain containing protein CXF51_16700 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CXF51_16705 ENOG4105EFZ amidohydrolase CXF51_16710 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CXF51_16745 ENOG4105U5Y Transcriptional regulator CXF51_16770 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CXF51_16785 ENOG4105F1V Acetoin utilization protein CXF51_16815 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CXF51_16835 ENOG4105DFU Cell wall formation (By similarity) CXF51_16845 ENOG4108VDD TRNA binding domain protein CXF51_16860 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ CXF51_16875 ENOG4105C6K Malic enzyme CXF51_16895 ENOG4108V15 phosphotransferase enzyme family CXF51_16900 ENOG4108IUM Glycogen debranching enzyme CXF51_16915 ENOG4107F58 2'-5' rna ligase CXF51_16920 ENOG4105C6T cysteine synthase CXF51_16945 ENOG4105YW5 deoR family transcriptional regulator CXF51_16975 ENOG4105MU9 integral membrane protein CXF51_16990 ENOG4105F5H Glycosyl Hydrolase Family 88 CXF51_17025 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CXF51_17035 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CXF51_17050 ENOG4105NTD Inherit from COG: Hydrolase CXF51_17065 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CXF51_17070 ENOG4105I1K ABC transporter CXF51_17085 ENOG4105C8T Leucyl-tRNA synthetase CXF51_17095 ENOG4105BZU Histidine kinase CXF51_17100 ENOG410605W Major Facilitator CXF51_17105 ENOG4106UBQ CXF51_17115 ENOG4105C19 ABC transporter CXF51_17120 ENOG4105EWM Histidine kinase CXF51_17135 ENOG4105C19 ABC transporter CXF51_17150 ENOG4105DVE abc transporter atp-binding protein CXF51_17160 ENOG4105N5T Radical SAM Protein CXF51_17180 ENOG4108Z0R Transferase CXF51_17195 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CXF51_17255 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CXF51_17260 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CXF51_17265 ENOG4108V2W Carbonate dehydratase CXF51_17295 ENOG4105CC5 ABC transporter CXF51_17300 ENOG4105DIK (ABC) transporter CXF51_17315 ENOG4105CEY Amp-dependent synthetase and ligase CXF51_17325 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CXF51_17375 ENOG4107SBE Glycosyl transferase (Group 1 CXF51_17380 ENOG4108KS4 Spore coat protein CXF51_17395 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CXF51_17405 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CXF51_17535 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CXF51_17540 ENOG4105VRR gCN5-related N-acetyltransferase CXF51_17545 ENOG4105DZ6 Band 7 protein CXF51_17555 ENOG4106DF1 CXF51_17565 ENOG4108JB8 alcohol dehydrogenase CXF51_17570 ENOG4105C26 Dehydrogenase CXF51_17590 ENOG4105CZN Potassium uptake protein CXF51_17630 ENOG4105EE0 oxidoreductase CXF51_17640 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) CXF51_17645 ENOG4105DET Rhamnulokinase CXF51_17650 ENOG4105E98 transcriptional regulator DeoR family CXF51_17675 ENOG4105C8Q Methyl-accepting chemotaxis CXF51_17695 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme CXF51_17720 ENOG4107PBV potassium channel CXF51_17750 ENOG4107QW4 alcohol dehydrogenase CXF51_17755 ENOG4105WG9 Conserved Protein CXF51_17770 ENOG4108ZB6 transcriptional regulator AsnC family CXF51_17775 ENOG4108MUZ hydrolase CXF51_17785 ENOG4105C87 Aminotransferase class I and II CXF51_17795 ENOG4105Y38 Kinase-associated protein B CXF51_17875 ENOG4105HC0 Na H antiporter CXF51_17900 ENOG4105KJM monovalent cation h antiporter subunit g CXF51_17905 ENOG4105KA0 thioesterase Superfamily protein CXF51_17940 ENOG4105D58 Diguanylate phosphodiesterase CXF51_17990 ENOG410904N short-chain dehydrogenase reductase CXF51_18040 ENOG4105DCF alanine dehydrogenase CXF51_18050 ENOG4105WQT MbtH domain protein CXF51_18060 ENOG4105WQI isochorismatase CXF51_18065 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CXF51_18070 ENOG4105E4F Isochorismate synthase CXF51_18075 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CXF51_18080 ENOG4105NIV Esterase CXF51_18100 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CXF51_18110 ENOG41069ER domain protein CXF51_18125 ENOG4105CEP NADH dehydrogenase CXF51_18155 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CXF51_18170 ENOG4105ZKE UPF0349 protein CXF51_18185 ENOG41083MR nifu domain-containing protein CXF51_18190 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein CXF51_18195 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CXF51_18205 ENOG4105D6E homoserine dehydrogenase CXF51_18215 ENOG4108W5N phosphatidylglycerophosphatase a CXF51_18220 ENOG4105D4U had-superfamily hydrolase, subfamily iia CXF51_18230 ENOG4105MMD transcriptional regulator CXF51_18235 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CXF51_18240 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CXF51_18245 ENOG4105FAA peptidase M23 CXF51_18250 ENOG4108YTE sporulation protein YunB CXF51_18255 ENOG4105KZD Domain of unknown function (DUF1805) CXF51_18260 ENOG4107R8B 5'-nucleotidase CXF51_18270 ENOG4105I3N Conserved Protein CXF51_18280 ENOG4105CD3 dihydroorotase CXF51_18285 ENOG4105G9B Transcriptional regulator CXF51_18300 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) CXF51_18305 ENOG4105VT2 5-hydroxyisourate hydrolase CXF51_18315 ENOG4107YV9 domain protein CXF51_18320 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding CXF51_18340 ENOG4105C5R Aminotransferase CXF51_18390 ENOG4105PKS Excinuclease abc c subunit domain protein CXF51_18410 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase CXF51_18415 ENOG4105NPE arsR family transcriptional regulator CXF51_18420 ENOG4105DIW FeS assembly protein SUFB CXF51_18425 ENOG4108UNV SUF system FeS assembly protein, NifU family CXF51_18430 ENOG4105C9B Cysteine desulfurase CXF51_18435 ENOG4105JRK feS assembly protein SufD CXF51_18440 ENOG4105C3K feS assembly ATPase SufC CXF51_18465 ENOG4108UMI ABC transporter, permease CXF51_18490 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CXF51_18495 ENOG41080E8 Transcriptional regulator, Spx MgsR family CXF51_18535 ENOG41067TZ transcriptional regulator, MarR family CXF51_18555 ENOG4105EGI Transcriptional regulator CXF51_18565 ENOG4105E0A ABC, transporter CXF51_18580 ENOG4105E1F short-chain dehydrogenase reductase CXF51_18585 ENOG4105HUF DNA protection during starvation protein CXF51_18590 ENOG4105C0H protease CXF51_18600 ENOG4105F3H Histidine kinase CXF51_18610 ENOG41067SE Tetr family transcriptional regulator CXF51_18615 ENOG4105C9Q fumarate hydratase class II CXF51_18645 ENOG4105ENE Histidine kinase CXF51_18675 ENOG4108WBT adenosyltransferase CXF51_18695 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CXF51_18740 ENOG4107RBB ABC transporter, permease CXF51_18745 ENOG4105C19 ABC transporter CXF51_18750 ENOG4108WMK Efflux transporter RND family MFP subunit CXF51_18755 ENOG4105E0A ABC, transporter CXF51_18780 ENOG4105D5Q Arginine ornithine antiporter CXF51_18795 ENOG4107K5X Membrane-bound metal-dependent hydrolase CXF51_18800 ENOG4107QZ2 Sulfatase CXF51_18805 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CXF51_18815 ENOG4105E0C molybdate abc transporter CXF51_18830 ENOG4105EEQ Na H antiporter CXF51_18860 ENOG4107ZQN disulfide bond CXF51_18875 ENOG410681U heavy metal transport detoxification protein CXF51_18880 ENOG4105VPX protein, conserved in bacteria CXF51_18885 ENOG4105D9R oxidoreductase CXF51_18900 ENOG4105RXJ CXF51_18905 ENOG4105KPY Small multidrug resistance protein CXF51_18910 ENOG4105KBX Transcriptional regulator, TetR family CXF51_18915 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CXF51_18925 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CXF51_18940 ENOG4105XZU Preprotein translocase, subunit SecG CXF51_18965 ENOG4105KVH Transcriptional regulator CXF51_18980 ENOG4108HQR Glycine betaine CXF51_18985 ENOG4105E90 ABC transporter CXF51_19005 ENOG4108HQR Glycine betaine CXF51_19010 ENOG4105E90 ABC transporter CXF51_19015 ENOG4108IJ8 ABC transporter CXF51_19020 ENOG4107HG4 Transcriptional regulator CXF51_19025 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CXF51_19030 ENOG4108QCI YvbH-like oligomerisation region CXF51_19040 ENOG4105T65 Membrane-associated protein CXF51_19045 ENOG4108W0I acetyltransferase CXF51_19050 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CXF51_19055 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CXF51_19060 ENOG4105CP7 Triose-phosphate isomerase CXF51_19065 ENOG4105BZA Phosphoglycerate kinase CXF51_19070 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CXF51_19090 ENOG4105DEN Luciferase family CXF51_19100 ENOG4105GZI Transcriptional regulator CXF51_19105 ENOG4107RT3 EamA-like transporter family CXF51_19110 ENOG4107RT3 EamA-like transporter family CXF51_19115 ENOG4107RT3 EamA-like transporter family CXF51_19135 ENOG4107QR9 Iron-sulfur cluster binding protein CXF51_19140 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CXF51_19155 ENOG4105KCT ABC transporter CXF51_19160 ENOG4108M15 ABC transporter CXF51_19165 ENOG4107R6F Alpha Beta Hydrolase Fold protein CXF51_19170 ENOG4108MJI response regulator CXF51_19185 ENOG4105EG2 ABC transporter, permease CXF51_19205 ENOG4105JXH GntR family transcriptional regulator CXF51_19225 ENOG4108ZPC Polysaccharide pyruvyl transferase CXF51_19250 ENOG4105K64 Glycosyl transferase, family 2 CXF51_19260 ENOG4107QRS glycosyltransferase group 2 family protein CXF51_19270 ENOG4108KMV Glycosyl transferase (Group 1 CXF51_19275 ENOG4105K64 Glycosyl transferase, family 2 CXF51_19280 ENOG4108PQP glycosyl transferase group 1 CXF51_19295 ENOG4105HTX biosynthesis protein CXF51_19315 ENOG4105PY6 Phenolic acid decarboxylase CXF51_19320 ENOG4105NI3 Protein of unknown function (DUF3237) CXF51_19345 ENOG4107QTZ amino acid CXF51_19375 ENOG4105IRW patatin-like phospholipase family protein CXF51_19385 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CXF51_19395 ENOG4105CG3 alpha amylase, catalytic region CXF51_19415 ENOG4105D56 permease protein CXF51_19420 ENOG4107FKK extracellular solute-binding protein family 1 CXF51_19435 ENOG4108URH decarboxylase CXF51_19440 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain CXF51_19445 ENOG4105CHH sulfate transporter CXF51_19450 ENOG4108V2W Carbonate dehydratase CXF51_19460 ENOG4105C5I Dehydrogenase CXF51_19470 ENOG4105C19 ABC transporter CXF51_19485 ENOG4107A6P CXF51_19495 ENOG4105KRI phosphocarrier protein (HPr CXF51_19510 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CXF51_19515 ENOG4108Z4K mutator MutT protein CXF51_19520 ENOG4105C3M thioredoxin reductase CXF51_19550 ENOG4106FGC CXF51_19560 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CXF51_19565 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CXF51_19575 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CXF51_19580 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CXF51_19590 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CXF51_19595 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CXF51_19610 ENOG4108S4C acetyltransferase CXF51_19615 ENOG4107XGZ Hydrolase CXF51_19635 ENOG4105CE4 GlcNAc 6-P deacetylase CXF51_19640 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CXF51_19645 ENOG4105FDP GntR family transcriptional regulator CXF51_19660 ENOG4106A3M Cytochrome p-450 CXF51_19680 ENOG41086DT Membrane protein of unknown function CXF51_19685 ENOG41067S9 phage shock protein C, PspC CXF51_19705 ENOG4105I03 Flagellin CXF51_19715 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CXF51_19730 ENOG4105MKU Transcriptional regulator CXF51_19755 ENOG4105CRP Part of the ABC transporter FtsEX involved in CXF51_19760 ENOG4105CAK Cell division ATP-binding protein ftsE CXF51_19775 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CXF51_19785 ENOG4105MS2 ribosomal subunit Interface protein CXF51_19800 ENOG4105MQ3 flagellar protein FliS CXF51_19810 ENOG41083S7 flagellar protein FlaG CXF51_19815 ENOG4105I03 Flagellin CXF51_19820 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CXF51_19835 ENOG4105DTJ flagellar hook-associated protein CXF51_19860 ENOG41081UC Inherit from COG: Competence protein CXF51_19890 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CXF51_19925 ENOG4105QZI O-Antigen Polymerase CXF51_19935 ENOG4107RA4 Glycosyl transferase (Group 1 CXF51_19940 ENOG4105PSV Polysaccharide Biosynthesis Protein CXF51_19945 ENOG4105D3Q Sugar transferase CXF51_19950 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CXF51_19955 ENOG4105JFG SpoIID LytB domain protein CXF51_19975 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CXF51_20010 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CXF51_20030 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) CXF51_20035 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase CXF51_20075 ENOG4108NHD germination protein CXF51_20080 ENOG4105C54 Major Facilitator superfamily CXF51_20095 ENOG4105K4H Nlp p60 protein CXF51_20125 ENOG4108RVA ribokinase CXF51_20130 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CXF51_20140 ENOG4105CNN ABC, transporter CXF51_20160 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CXF51_20165 ENOG4107FQX Alpha-acetolactate decarboxylase CXF51_20175 ENOG4107RSM transcriptional regulator CXF51_20205 ENOG4107XC4 flavin reductase domain protein, FMN-binding CXF51_20215 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CXF51_20225 ENOG4105CAH Chromate CXF51_20230 ENOG4105FGV Chromate CXF51_20240 ENOG4108WS4 fmn reductase CXF51_20245 ENOG4107V2S Transcriptional regulator CXF51_20315 ENOG4105C6Y Udp-glucose 6-dehydrogenase CXF51_20330 ENOG4105HTX biosynthesis protein CXF51_20360 ENOG4105Z8H single-stranded DNA-binding protein CXF51_20385 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CXF51_20390 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CXF51_20410 ENOG4105DFF Rod shape-determining protein mreb CXF51_20415 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CXF51_20425 ENOG4107MII Sugar-specific transcriptional regulator TrmB CXF51_20430 ENOG4105CZM Major Facilitator CXF51_20445 ENOG41080V3 Major Facilitator superfamily CXF51_20455 ENOG4107P26 CXF51_20485 ENOG4107TCE N-acetyltransferase CXF51_20500 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CXF51_20505 ENOG4107TXC Transcriptional regulator CXF51_20510 ENOG4106BRK CXF51_20515 ENOG4108RYK Nad-dependent epimerase dehydratase CXF51_20520 ENOG4108Z40 Transcriptional regulator CXF51_20530 ENOG4105KI2 Urea amidohydrolase subunit beta CXF51_20535 ENOG4108YZ9 Urea amidohydrolase subunit gamma CXF51_20575 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CXF51_20585 ENOG4108TF4 von Willebrand factor, type A CXF51_20595 ENOG4105JFG SpoIID LytB domain protein CXF51_20600 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CXF51_20620 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CXF51_20625 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CXF51_20630 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CXF51_20635 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CXF51_20655 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) CXF51_20665 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CXF51_20670 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CXF51_20675 ENOG4108UIC UPF0340 protein CXF51_20680 ENOG4108YZG isomerase CXF51_20685 ENOG4107WAU Protein tyrosine phosphatase CXF51_20690 ENOG410815N Probably functions as a manganese efflux pump (By similarity) CXF51_20720 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CXF51_20725 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CXF51_20730 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CXF51_20750 ENOG4107104 thymidine kinase CXF51_20755 ENOG41082DI 50s ribosomal protein l31 CXF51_20775 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway CXF51_20780 ENOG4105D2N Aldolase CXF51_20785 ENOG410812K response regulator receiver protein CXF51_20805 ENOG4105C1G acyl-Coa dehydrogenase CXF51_20810 ENOG4105DF6 Fe-S oxidoreductase CXF51_20820 ENOG4105E5J UV damage endonuclease CXF51_20840 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CXF51_20850 ENOG4105R3A Nitrate reductase CXF51_20855 ENOG4108IUE nitrate reductase beta subunit CXF51_20890 ENOG410684U Domain of unknown function (DUF1934) CXF51_20905 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E CXF51_20995 ENOG4105CYW agmatinase CXF51_21000 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CXF51_21010 ENOG4108XFG YwhD family CXF51_21015 ENOG4108Z4T Peptidase M50 CXF51_21020 ENOG41069HH 4-oxalocrotonate tautomerase CXF51_21025 ENOG41067TZ transcriptional regulator, MarR family CXF51_21030 ENOG4105C22 threonyL-tRNA synthetase CXF51_21040 ENOG41062ES Transcriptional regulator CXF51_21050 ENOG4105DCI Phosphohydrolase CXF51_21060 ENOG4108VCI transcription factor, rsfa family CXF51_21070 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CXF51_21075 ENOG4105DUM transcriptional regulator, lysR family CXF51_21080 ENOG4108IJ2 phosphate acetyltransferase CXF51_21115 ENOG4106CHD Bacilysin biosynthesis protein bacB CXF51_21125 ENOG4105FCW Major Facilitator superfamily CXF51_21140 ENOG4105C26 Dehydrogenase CXF51_21155 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase CXF51_21170 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CXF51_21175 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG CXF51_21180 ENOG4107TY6 Acylneuraminate cytidylyltransferase CXF51_21240 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CXF51_21245 ENOG4108RJ9 Glycosyl transferase, family 2 CXF51_21265 ENOG4105DWF phosphomethylpyrimidine kinase CXF51_21285 ENOG4108QTI )-transporter CXF51_21305 ENOG4105DEN Luciferase family CXF51_21310 ENOG4108DBC nitroreductase CXF51_21325 ENOG41060D1 Quinol oxidase CXF51_21330 ENOG4105CCU oxidase (Subunit III) CXF51_21335 ENOG4105BZ9 Cytochrome C oxidase, subunit I CXF51_21385 ENOG4107ZXU DSBA oxidoreductase CXF51_21395 ENOG410650H (LipO)protein CXF51_21400 ENOG4107SJW iron permease, FTR1 CXF51_21405 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CXF51_21415 ENOG4105CMU LysR family (Transcriptional regulator CXF51_21425 ENOG41067MG lrgb family CXF51_21430 ENOG4105D8G Major Facilitator superfamily CXF51_21440 ENOG4105DR4 Methyltransferase CXF51_21515 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CXF51_21530 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) CXF51_21560 ENOG4105F8D glycoside hydrolase family 4 CXF51_21565 ENOG4105VCP PTS System CXF51_21570 ENOG4105CK1 PTS System CXF51_21590 ENOG4108VX5 3-methyladenine DNA glycosylase CXF51_21615 ENOG41069JR CXF51_21645 ENOG4108JJ8 (ABC) transporter CXF51_21655 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CXF51_21660 ENOG4105C4M (Ubiquinol oxidase) subunit I CXF51_21680 ENOG4107BJW polysaccharide deacetylase CXF51_21710 ENOG4105CMR udp-glucose 4-epimerase CXF51_21725 ENOG4105WH1 Two component transcriptional regulator luxr family CXF51_21730 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CXF51_21755 ENOG4105DTD Dehydrogenase CXF51_21765 ENOG4105D6N CoA-transferase, subunit a CXF51_21775 ENOG4105DHI Methyltransferase CXF51_21795 ENOG4105CH6 catalase CXF51_21800 ENOG4105D4T Citrate transporter CXF51_21810 ENOG4105CID antiterminator CXF51_21820 ENOG4105DEU major facilitator superfamily CXF51_21825 ENOG4105C1J atp-dependent rna helicase CXF51_21830 ENOG4107TDE lipolytic protein G-D-S-L family CXF51_21905 ENOG4108Z6Z Transcriptional regulator CXF51_21960 ENOG4106Z5D Glycoside Hydrolase Family 43 CXF51_21975 ENOG4105C84 Histidine ammonia-lyase CXF51_21985 ENOG4105CI2 imidazolone-5-propionate hydrolase CXF51_22000 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CXF51_22005 ENOG4105D9N nucleoside CXF51_22015 ENOG4107RHR regulatoR CXF51_22020 ENOG4108TM9 integral membrane protein CXF51_22025 ENOG4105ENY Ethanolamine utilization protein eutH CXF51_22030 ENOG4108PGP mmge prpd family protein CXF51_22035 ENOG4105CH2 amidohydrolase CXF51_22070 ENOG4107QHE Choloylglycine hydrolase CXF51_22075 ENOG410667J hydrolase CXF51_22105 ENOG4108V5C ABC transporter CXF51_22135 ENOG4105D2N Aldolase CXF51_22140 ENOG4107TRN Xylose isomerase domain protein TIM barrel CXF51_22145 ENOG4105F0H myo-inositol catabolism protein CXF51_22150 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CXF51_22160 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CXF51_22170 ENOG4105D7K pfkb domain protein CXF51_22175 ENOG4105DH8 myo-inositol catabolism CXF51_22180 ENOG4105C26 Dehydrogenase CXF51_22205 ENOG4107QNK )-transporter CXF51_22210 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CXF51_22235 ENOG4108YM7 Gcn5-related n-acetyltransferase CXF51_22265 ENOG4105F22 Major Facilitator Superfamily CXF51_22270 ENOG4108ITS PQQ enzyme repeat CXF51_22280 ENOG41085PJ rdd domain containing protein CXF51_22295 ENOG4105J7D transcriptional regulator CXF51_22305 ENOG41061AU MarR family Transcriptional regulator CXF51_22315 ENOG41067MG lrgb family CXF51_22330 ENOG4105G3Z GntR family transcriptional regulator CXF51_22345 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CXF51_22350 ENOG4105D3R alkyl hydroperoxide reductase CXF51_22355 ENOG4108JU3 Alkyl hydroperoxide reductase CXF51_22360 ENOG4105CS2 ec 3.2.1.21 CXF51_22410 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CXF51_22445 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) CXF51_22450 ENOG4105WQG acetyltransferase CXF51_22465 ENOG41066UZ arginase EC 3.5.3.1 CXF51_22470 ENOG4108IQI permease CXF51_22475 ENOG4105C8Y Acetylornithine aminotransferase CXF51_22480 ENOG4108JUB Transcriptional regulator CXF51_22485 ENOG4105BZU Histidine kinase CXF51_22505 ENOG4105C0H protease CXF51_22510 ENOG4105Q2H domain protein CXF51_22525 ENOG4105BZU Histidine kinase CXF51_22530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CXF51_22565 ENOG4105CDU Replicative dna helicase CXF51_22585 ENOG4105DJ2 Major Facilitator Superfamily CXF51_22605 ENOG4108XMW Membrane CXF51_22620 ENOG4105KVH Transcriptional regulator CXF51_22625 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase CXF51_22655 ENOG4105DDN Pentapeptide repeat-containing protein CXF51_22670 ENOG41082BV acetyltransferase CXF51_22675 ENOG41081I9 integral membrane protein CXF51_22695 ENOG41082BV acetyltransferase CXF51_22705 ENOG4108U7W acetyltransferase CXF51_22715 ENOG4105NAE bifunctional deaminase-reductase domain protein CXF51_22735 ENOG4105C7Z Conserved Protein CXF51_22740 ENOG4108Z5V transcriptional regulator, merr family CXF51_22745 ENOG4108UQV Membrane CXF51_22750 ENOG4105C7Z Conserved Protein CXF51_22770 ENOG4108UW5 maltose o-acetyltransferase CXF51_22775 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CXF51_22785 ENOG4105CGK Exodeoxyribonuclease III CXF51_22790 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CXF51_22800 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CXF51_22805 ENOG4105C3G gtp-binding protein CXF51_22810 ENOG4108J2R molybdopterin oxidoreductase CXF51_22815 ENOG4105VDK protein, conserved in bacteria CXF51_22825 ENOG4108ZDA Sporulation protein YyaC CXF51_22835 ENOG4107QJE Chromosome Partitioning Protein CXF51_22850 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CXF51_22875 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)