locus-tag class description KHRBS_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) KHRBS_00015 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) KHRBS_00030 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) KHRBS_00035 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) KHRBS_00040 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) KHRBS_00055 ENOG4107QJE Chromosome Partitioning Protein KHRBS_00060 ENOG4105FA0 parb-like partition protein KHRBS_00065 ENOG4108ZDA Sporulation protein YyaC KHRBS_00075 ENOG4105VDK protein, conserved in bacteria KHRBS_00080 ENOG4108J2R molybdopterin oxidoreductase KHRBS_00085 ENOG4105C3G gtp-binding protein KHRBS_00090 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) KHRBS_00095 ENOG4108UUM single-stranded DNA-binding protein KHRBS_00100 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) KHRBS_00105 ENOG4105CGK Exodeoxyribonuclease III KHRBS_00115 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase KHRBS_00120 ENOG4108UW5 maltose o-acetyltransferase KHRBS_00130 ENOG4107FCW Abortive infection protein KHRBS_00135 ENOG4105C7Z Conserved Protein KHRBS_00140 ENOG4108IPJ Membrane KHRBS_00160 ENOG4105C7Z Conserved Protein KHRBS_00165 ENOG4108J8C transporter major facilitator family protein KHRBS_00170 ENOG4105NAE bifunctional deaminase-reductase domain protein KHRBS_00175 ENOG4105UNS Pfam:DUF419 KHRBS_00180 ENOG4108U7W acetyltransferase KHRBS_00190 ENOG41082BV acetyltransferase KHRBS_00195 ENOG4108U05 Transcriptional regulator KHRBS_00205 ENOG41081I9 integral membrane protein KHRBS_00210 ENOG41082BV acetyltransferase KHRBS_00215 ENOG4107RSM transcriptional regulator KHRBS_00220 ENOG4105D94 Major Facilitator Superfamily KHRBS_00225 ENOG4105DDN Pentapeptide repeat-containing protein KHRBS_00230 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein KHRBS_00255 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase KHRBS_00260 ENOG4105KVH Transcriptional regulator KHRBS_00275 ENOG4108XMW Membrane KHRBS_00285 ENOG4105K9Q Binds to the 23S rRNA (By similarity) KHRBS_00290 ENOG4105EDW glycosyl transferase, family 39 KHRBS_00295 ENOG4105DJ2 Major Facilitator Superfamily KHRBS_00320 ENOG4105CDU Replicative dna helicase KHRBS_00325 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase KHRBS_00330 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis KHRBS_00355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KHRBS_00360 ENOG4105BZU Histidine kinase KHRBS_00375 ENOG4105Q2H domain protein KHRBS_00380 ENOG4105C0H protease KHRBS_00410 ENOG4108JUB Transcriptional regulator KHRBS_00415 ENOG4105C8Y Acetylornithine aminotransferase KHRBS_00420 ENOG4108IQI permease KHRBS_00425 ENOG41066UZ arginase EC 3.5.3.1 KHRBS_00440 ENOG4105WQG acetyltransferase KHRBS_00445 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) KHRBS_00465 ENOG4105E2A Dehydrogenase KHRBS_00475 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) KHRBS_00515 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 KHRBS_00525 ENOG4108S3Y transcriptional regulator KHRBS_00535 ENOG4105CS2 ec 3.2.1.21 KHRBS_00545 ENOG4108JU3 Alkyl hydroperoxide reductase KHRBS_00550 ENOG4105D3R alkyl hydroperoxide reductase KHRBS_00555 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) KHRBS_00560 ENOG4105C6Z Gluconate KHRBS_00565 ENOG4105CMG Carbohydrate kinase KHRBS_00570 ENOG4105G3Z GntR family transcriptional regulator KHRBS_00575 ENOG4105BZW Glycerate kinase KHRBS_00585 ENOG41067MG lrgb family KHRBS_00595 ENOG41061AU MarR family Transcriptional regulator KHRBS_00600 ENOG4107JEE Short-chain dehydrogenase reductase Sdr KHRBS_00605 ENOG4105J7D transcriptional regulator KHRBS_00620 ENOG41085PJ rdd domain containing protein KHRBS_00630 ENOG4108ITS PQQ enzyme repeat KHRBS_00645 ENOG4105ST3 Transcriptional regulator KHRBS_00650 ENOG41061TZ Short-chain dehydrogenase reductase Sdr KHRBS_00660 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) KHRBS_00665 ENOG4107QNK )-transporter KHRBS_00680 ENOG4105CPC Aldo Keto reductase KHRBS_00690 ENOG4105C26 Dehydrogenase KHRBS_00700 ENOG4105D7K pfkb domain protein KHRBS_00710 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) KHRBS_00720 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KHRBS_00725 ENOG4105F0H myo-inositol catabolism protein KHRBS_00730 ENOG4107TRN Xylose isomerase domain protein TIM barrel KHRBS_00735 ENOG4105D2N Aldolase KHRBS_00765 ENOG4108V5C ABC transporter KHRBS_00795 ENOG410667J hydrolase KHRBS_00800 ENOG4107QHE Choloylglycine hydrolase KHRBS_00810 ENOG4105CPU Monooxygenase KHRBS_00815 ENOG4108XSB acetyltransferase, (GNAT) family KHRBS_00820 ENOG4105EAB amino acid AbC transporter KHRBS_00825 ENOG4108HW4 amino acid AbC transporter KHRBS_00835 ENOG4105CH2 amidohydrolase KHRBS_00840 ENOG4108PGP mmge prpd family protein KHRBS_00845 ENOG4105ENY Ethanolamine utilization protein eutH KHRBS_00850 ENOG4108TM9 integral membrane protein KHRBS_00855 ENOG4107RHR regulatoR KHRBS_00865 ENOG4105D9N nucleoside KHRBS_00870 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) KHRBS_00890 ENOG4105CGP Urocanate hydratase KHRBS_00895 ENOG4105C84 Histidine ammonia-lyase KHRBS_00905 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) KHRBS_00905 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) KHRBS_00925 ENOG4106Z5D Glycoside Hydrolase Family 43 KHRBS_00940 ENOG4107EV6 Inherit from COG: YD repeat protein KHRBS_00955 ENOG4105C5Y PTS System KHRBS_00960 ENOG4105CS2 ec 3.2.1.21 KHRBS_00965 ENOG4107YZX Universal stress protein KHRBS_01020 ENOG4107TDE lipolytic protein G-D-S-L family KHRBS_01030 ENOG4105DEU major facilitator superfamily KHRBS_01040 ENOG4105CID antiterminator KHRBS_01045 ENOG4108RZ2 Glycoside hydrolase family 16 KHRBS_01050 ENOG4105D4T Citrate transporter KHRBS_01055 ENOG4105CH6 catalase KHRBS_01075 ENOG4105DHI Methyltransferase KHRBS_01085 ENOG4105CY2 Citrate transporter KHRBS_01090 ENOG4105D6N CoA-transferase, subunit a KHRBS_01095 ENOG4108IIH CoA-transferase subunit B KHRBS_01100 ENOG4105DTD Dehydrogenase KHRBS_01130 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KHRBS_01135 ENOG4105WH1 Two component transcriptional regulator luxr family KHRBS_01140 ENOG4105BZU Histidine kinase KHRBS_01150 ENOG4108WAV Transcriptional regulator KHRBS_01155 ENOG4105KIS phospholipid-binding protein KHRBS_01160 ENOG4105CMR udp-glucose 4-epimerase KHRBS_01170 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) KHRBS_01205 ENOG4105D2K citrate carrier protein KHRBS_01215 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii KHRBS_01220 ENOG4108JJ9 ABC, transporter KHRBS_01235 ENOG4105ETS cytosine purines uracil thiamine allantoin KHRBS_01255 ENOG41069JR KHRBS_01260 ENOG4105DA5 (ABC) transporter KHRBS_01275 ENOG4105CH6 catalase KHRBS_01280 ENOG4108VX5 3-methyladenine DNA glycosylase KHRBS_01290 ENOG4105EMD TRANSCRIPTIONal KHRBS_01295 ENOG4105VZJ PTS System KHRBS_01300 ENOG4105CK1 PTS System KHRBS_01305 ENOG4105VCP PTS System KHRBS_01310 ENOG4105F8D glycoside hydrolase family 4 KHRBS_01315 ENOG4105CM2 brancheD-chain amino acid aminotransferase KHRBS_01320 ENOG4108VHC Short-chain dehydrogenase reductase Sdr KHRBS_01325 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD KHRBS_01335 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein KHRBS_01340 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) KHRBS_01355 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase KHRBS_01385 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KHRBS_01390 ENOG4105GVJ transcriptional regulator KHRBS_01420 ENOG4105CK1 PTS System KHRBS_01430 ENOG4105DR4 Methyltransferase KHRBS_01440 ENOG4105D8G Major Facilitator superfamily KHRBS_01445 ENOG41067MG lrgb family KHRBS_01450 ENOG4105VAW lrga family KHRBS_01455 ENOG4105CMU LysR family (Transcriptional regulator KHRBS_01465 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) KHRBS_01470 ENOG4107SJW iron permease, FTR1 KHRBS_01475 ENOG410650H (LipO)protein KHRBS_01480 ENOG4105DBE peroxidase KHRBS_01485 ENOG4107ZXU DSBA oxidoreductase KHRBS_01510 ENOG4105WH5 Teichoic acid glycosylation protein KHRBS_01525 ENOG4107BMA Transglycosylase associated protein KHRBS_01530 ENOG4105E2S oxidase) subunit II KHRBS_01535 ENOG4105BZ9 Cytochrome C oxidase, subunit I KHRBS_01545 ENOG41060D1 Quinol oxidase KHRBS_01560 ENOG4108DBC nitroreductase KHRBS_01565 ENOG4105DEN Luciferase family KHRBS_01585 ENOG4108QTI )-transporter KHRBS_01590 ENOG4105C5Y PTS System KHRBS_01605 ENOG4105DWF phosphomethylpyrimidine kinase KHRBS_01625 ENOG4108RJ9 Glycosyl transferase, family 2 KHRBS_01630 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) KHRBS_01635 ENOG4105C26 Dehydrogenase KHRBS_01680 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD KHRBS_01690 ENOG4107TY6 Acylneuraminate cytidylyltransferase KHRBS_01700 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) KHRBS_01705 ENOG4105C1B dTDP-glucose 4-6-dehydratase KHRBS_01710 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase KHRBS_01715 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase KHRBS_01725 ENOG4105D82 Glutamate dehydrogenase KHRBS_01730 ENOG4105C26 Dehydrogenase KHRBS_01745 ENOG4105FCW Major Facilitator superfamily KHRBS_01750 ENOG41061WN bacilysin biosynthesis protein KHRBS_01755 ENOG4106CHD Bacilysin biosynthesis protein bacB KHRBS_01760 ENOG4105CHR reductase KHRBS_01775 ENOG4105CHM Aminotransferase KHRBS_01790 ENOG4108IJ2 phosphate acetyltransferase KHRBS_01795 ENOG4105DUM transcriptional regulator, lysR family KHRBS_01800 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) KHRBS_01805 ENOG4108RNG Permease of the drug metabolite transporter KHRBS_01810 ENOG4108VCI transcription factor, rsfa family KHRBS_01820 ENOG4105DCI Phosphohydrolase KHRBS_01830 ENOG41062ES Transcriptional regulator KHRBS_01835 ENOG4105C57 major facilitator superfamily KHRBS_01845 ENOG4105C22 threonyL-tRNA synthetase KHRBS_01850 ENOG41067TZ transcriptional regulator, MarR family KHRBS_01855 ENOG41069HH 4-oxalocrotonate tautomerase KHRBS_01860 ENOG4108Z4T Peptidase M50 KHRBS_01865 ENOG4108XFG YwhD family KHRBS_01875 ENOG4105BZ4 penicillin-binding protein KHRBS_01885 ENOG4105CYW agmatinase KHRBS_01950 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E KHRBS_01960 ENOG410684U Domain of unknown function (DUF1934) KHRBS_01965 ENOG4105C75 arginyL-tRNA synthetase KHRBS_01975 ENOG4107V6Q Cyclic nucleotide-binding domain KHRBS_01995 ENOG4108IUE nitrate reductase beta subunit KHRBS_02000 ENOG4105R3A Nitrate reductase KHRBS_02015 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KHRBS_02020 ENOG4105BZ1 (ABC) transporter KHRBS_02025 ENOG4105NAE bifunctional deaminase-reductase domain protein KHRBS_02035 ENOG4105E5J UV damage endonuclease KHRBS_02045 ENOG4105DF6 Fe-S oxidoreductase KHRBS_02050 ENOG4105C1G acyl-Coa dehydrogenase KHRBS_02070 ENOG410812K response regulator receiver protein KHRBS_02075 ENOG4105D2N Aldolase KHRBS_02080 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway KHRBS_02085 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KHRBS_02115 ENOG4105C6K Malic enzyme KHRBS_02120 ENOG4107TT2 Auxin Efflux Carrier KHRBS_02130 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase KHRBS_02135 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) KHRBS_02140 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) KHRBS_02155 ENOG4108ZXQ stage ii sporulation protein r KHRBS_02165 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KHRBS_02170 ENOG410815N Probably functions as a manganese efflux pump (By similarity) KHRBS_02175 ENOG4107WAU Protein tyrosine phosphatase KHRBS_02180 ENOG4108YZG isomerase KHRBS_02185 ENOG4108UIC UPF0340 protein KHRBS_02190 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) KHRBS_02195 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) KHRBS_02205 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) KHRBS_02230 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) KHRBS_02235 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) KHRBS_02240 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) KHRBS_02245 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) KHRBS_02255 ENOG4106778 Protein of unknown function (DUF1146) KHRBS_02265 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KHRBS_02270 ENOG4105JFG SpoIID LytB domain protein KHRBS_02285 ENOG4108TF4 von Willebrand factor, type A KHRBS_02295 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) KHRBS_02330 ENOG4108YZ9 Urea amidohydrolase subunit gamma KHRBS_02335 ENOG4105KI2 Urea amidohydrolase subunit beta KHRBS_02345 ENOG4108Z40 Transcriptional regulator KHRBS_02350 ENOG4108RYK Nad-dependent epimerase dehydratase KHRBS_02355 ENOG4106BRK KHRBS_02360 ENOG4107TXC Transcriptional regulator KHRBS_02365 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KHRBS_02385 ENOG4107TCE N-acetyltransferase KHRBS_02390 ENOG4105FRN stage II sporulation protein KHRBS_02415 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase KHRBS_02425 ENOG4105BZU Histidine kinase KHRBS_02430 ENOG4107P26 KHRBS_02435 ENOG4105D3W isochorismatase KHRBS_02440 ENOG41080V3 Major Facilitator superfamily KHRBS_02445 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease KHRBS_02450 ENOG4108M26 parallel beta-helix repeat protein KHRBS_02455 ENOG4105CZM Major Facilitator KHRBS_02460 ENOG4107MII Sugar-specific transcriptional regulator TrmB KHRBS_02465 ENOG4105MT0 Sporulation transcriptional regulator spoiiid KHRBS_02470 ENOG4105DFF Rod shape-determining protein mreb KHRBS_02480 ENOG4105CGA flagellar basal-body rod protein FlgG KHRBS_02490 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) KHRBS_02495 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) KHRBS_02520 ENOG4105Z8H single-stranded DNA-binding protein KHRBS_02525 ENOG4105E98 transcriptional regulator DeoR family KHRBS_02530 ENOG410667J hydrolase KHRBS_02535 ENOG4105C0D helicase KHRBS_02550 ENOG4105HTX biosynthesis protein KHRBS_02560 ENOG4108RB3 Capsular polysaccharide biosynthesis protein KHRBS_02565 ENOG4105C6Y Udp-glucose 6-dehydrogenase KHRBS_02570 ENOG4108XI2 Domain of unknown function (DUF1963) KHRBS_02615 ENOG4107V2S Transcriptional regulator KHRBS_02620 ENOG4108WS4 fmn reductase KHRBS_02630 ENOG4105FGV Chromate KHRBS_02635 ENOG4105CAH Chromate KHRBS_02645 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KHRBS_02655 ENOG4107XC4 flavin reductase domain protein, FMN-binding KHRBS_02685 ENOG4107RSM transcriptional regulator KHRBS_02695 ENOG4107FQX Alpha-acetolactate decarboxylase KHRBS_02700 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein KHRBS_02715 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KHRBS_02720 ENOG4105CNN ABC, transporter KHRBS_02725 ENOG4105C2J ABC transporter KHRBS_02730 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) KHRBS_02735 ENOG4108RVA ribokinase KHRBS_02745 ENOG4105N98 Capsule biosynthesis protein capB KHRBS_02755 ENOG4105PNM synthesis protein KHRBS_02765 ENOG4105K4H Nlp p60 protein KHRBS_02770 ENOG4105J7I hydrolase KHRBS_02775 ENOG4108KGH TRANSCRIPTIONal KHRBS_02780 ENOG4105C54 Major Facilitator superfamily KHRBS_02785 ENOG4108NHD germination protein KHRBS_02805 ENOG4105DG6 mannose-6-phosphate isomerase KHRBS_02875 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KHRBS_02895 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase KHRBS_02925 ENOG4105D3Q Sugar transferase KHRBS_02930 ENOG4105PSV Polysaccharide Biosynthesis Protein KHRBS_02935 ENOG4107RA4 Glycosyl transferase (Group 1 KHRBS_02940 ENOG4105C6Y Udp-glucose 6-dehydrogenase KHRBS_02945 ENOG4105QZI O-Antigen Polymerase KHRBS_02960 ENOG4107EF8 Glycosyl transferase (Group 1 KHRBS_02975 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein KHRBS_02980 ENOG4105BZU Histidine kinase KHRBS_02985 ENOG4105WH1 Two component transcriptional regulator luxr family KHRBS_03005 ENOG41081UC Inherit from COG: Competence protein KHRBS_03010 ENOG4105RU3 KHRBS_03025 ENOG4105E1Q flagellar hook-associated protein KHRBS_03030 ENOG4105DTJ flagellar hook-associated protein KHRBS_03035 ENOG4105MKD KHRBS_03040 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) KHRBS_03045 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) KHRBS_03050 ENOG4105I03 Flagellin KHRBS_03055 ENOG41083S7 flagellar protein FlaG KHRBS_03060 ENOG4107RT6 flagellar hook-associated KHRBS_03065 ENOG4105MQ3 flagellar protein FliS KHRBS_03080 ENOG4105MS2 ribosomal subunit Interface protein KHRBS_03090 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) KHRBS_03105 ENOG4105CAK Cell division ATP-binding protein ftsE KHRBS_03110 ENOG4105CRP Part of the ABC transporter FtsEX involved in KHRBS_03115 ENOG4105CN1 protease KHRBS_03135 ENOG4105MKU Transcriptional regulator KHRBS_03150 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) KHRBS_03155 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) KHRBS_03175 ENOG4108PY7 KHRBS_03180 ENOG41067S9 phage shock protein C, PspC KHRBS_03185 ENOG41086DT Membrane protein of unknown function KHRBS_03200 ENOG410625E KHRBS_03205 ENOG4106A3M Cytochrome p-450 KHRBS_03215 ENOG41088CQ domain protein KHRBS_03220 ENOG4105FDP GntR family transcriptional regulator KHRBS_03225 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) KHRBS_03230 ENOG4105CE4 GlcNAc 6-P deacetylase KHRBS_03235 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) KHRBS_03240 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) KHRBS_03245 ENOG4105HKU nucleoside recognition domain-containing protein KHRBS_03250 ENOG4107XGZ Hydrolase KHRBS_03255 ENOG4108S4C acetyltransferase KHRBS_03260 ENOG4108E16 pectate lyase KHRBS_03270 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) KHRBS_03275 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) KHRBS_03280 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) KHRBS_03285 ENOG4105ECC imidazole-glycerol-phosphate dehydratase KHRBS_03290 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) KHRBS_03295 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase KHRBS_03300 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) KHRBS_03305 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase KHRBS_03320 ENOG4106FGC KHRBS_03330 ENOG4105BZ1 (ABC) transporter KHRBS_03345 ENOG4105C3M thioredoxin reductase KHRBS_03350 ENOG4108Z4K mutator MutT protein KHRBS_03360 ENOG4105CHW UPF0052 protein KHRBS_03370 ENOG4105KRI phosphocarrier protein (HPr KHRBS_03380 ENOG4107A6P KHRBS_03390 ENOG4105EWM Histidine kinase KHRBS_03395 ENOG4105C19 ABC transporter KHRBS_03405 ENOG4105C5I Dehydrogenase KHRBS_03410 ENOG4108V2W Carbonate dehydratase KHRBS_03415 ENOG4105CHH sulfate transporter KHRBS_03420 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain KHRBS_03425 ENOG4108URH decarboxylase KHRBS_03430 ENOG4105FKQ transcriptional regulator KHRBS_03435 ENOG4108IUK alpha amylase, catalytic KHRBS_03440 ENOG4107FKK extracellular solute-binding protein family 1 KHRBS_03445 ENOG4105D56 permease protein KHRBS_03450 ENOG4105EG2 ABC transporter, permease KHRBS_03465 ENOG4105CG3 alpha amylase, catalytic region KHRBS_03470 ENOG4107URF beta-phospho-glucomutase KHRBS_03475 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) KHRBS_03485 ENOG4105IRW patatin-like phospholipase family protein KHRBS_03490 ENOG4105DNP FAD linked oxidase domain protein KHRBS_03515 ENOG4107QTZ amino acid KHRBS_03520 ENOG4108HKT sucrose-6-phosphate hydrolase KHRBS_03525 ENOG4105EDQ levansucrase EC 2.4.1.10 KHRBS_03530 ENOG4105FQP Beta-lactamase KHRBS_03540 ENOG4105NI3 Protein of unknown function (DUF3237) KHRBS_03545 ENOG4105PY6 Phenolic acid decarboxylase KHRBS_03555 ENOG4105EBR Carboxylesterase KHRBS_03565 ENOG4105HTX biosynthesis protein KHRBS_03570 ENOG4108QV3 biosynthesis protein KHRBS_03580 ENOG4108PQP glycosyl transferase group 1 KHRBS_03585 ENOG4105K64 Glycosyl transferase, family 2 KHRBS_03590 ENOG4108KMV Glycosyl transferase (Group 1 KHRBS_03595 ENOG41068W6 Capsular polysaccharide biosynthesis protein KHRBS_03600 ENOG4107QRS glycosyltransferase group 2 family protein KHRBS_03620 ENOG4105D3Q Sugar transferase KHRBS_03625 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family KHRBS_03630 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KHRBS_03635 ENOG4108ZPC Polysaccharide pyruvyl transferase KHRBS_03645 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHRBS_03650 ENOG4105DAA L-lactate KHRBS_03665 ENOG4107FKK extracellular solute-binding protein family 1 KHRBS_03675 ENOG4105EG2 ABC transporter, permease KHRBS_03690 ENOG4108MJI response regulator KHRBS_03695 ENOG4107R6F Alpha Beta Hydrolase Fold protein KHRBS_03700 ENOG4108M15 ABC transporter KHRBS_03705 ENOG4105KCT ABC transporter KHRBS_03710 ENOG4105BZU Histidine kinase KHRBS_03720 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KHRBS_03725 ENOG4107QR9 Iron-sulfur cluster binding protein KHRBS_03730 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) KHRBS_03735 ENOG4105VRS hydrolase family 18 KHRBS_03745 ENOG4107RT3 EamA-like transporter family KHRBS_03750 ENOG4105GZI Transcriptional regulator KHRBS_03755 ENOG4105DEN Luciferase family KHRBS_03760 ENOG4105CMD Transcriptional regulator, GntR family KHRBS_03775 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KHRBS_03785 ENOG4105BZA Phosphoglycerate kinase KHRBS_03790 ENOG4105CP7 Triose-phosphate isomerase KHRBS_03795 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) KHRBS_03800 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) KHRBS_03805 ENOG4108W0I acetyltransferase KHRBS_03810 ENOG4105T65 Membrane-associated protein KHRBS_03820 ENOG4108QCI YvbH-like oligomerisation region KHRBS_03825 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein KHRBS_03830 ENOG4107HG4 Transcriptional regulator KHRBS_03835 ENOG4108IJ8 ABC transporter KHRBS_03840 ENOG4105E90 ABC transporter KHRBS_03845 ENOG4108HQR Glycine betaine KHRBS_03850 ENOG4105R40 Glycine betaine carnitine choline KHRBS_03855 ENOG41082BM Transcriptional regulator, arsr family KHRBS_03870 ENOG4105H5S KHRBS_03880 ENOG4107HG4 Transcriptional regulator KHRBS_03890 ENOG4105E90 ABC transporter KHRBS_03895 ENOG4108HQR Glycine betaine KHRBS_03900 ENOG4105R40 Glycine betaine carnitine choline KHRBS_03905 ENOG4105C8Q Methyl-accepting chemotaxis KHRBS_03910 ENOG4105KVH Transcriptional regulator KHRBS_03935 ENOG4105XZU Preprotein translocase, subunit SecG KHRBS_03945 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) KHRBS_03950 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) KHRBS_03965 ENOG4105KBX Transcriptional regulator, TetR family KHRBS_03970 ENOG4105KPY Small multidrug resistance protein KHRBS_03975 ENOG4105RXJ KHRBS_03980 ENOG4105ME7 Membrane KHRBS_03985 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KHRBS_03990 ENOG4105D9R oxidoreductase KHRBS_03995 ENOG4105VPX protein, conserved in bacteria KHRBS_04000 ENOG410681U heavy metal transport detoxification protein KHRBS_04005 ENOG4105C59 p-type ATPase KHRBS_04010 ENOG4105C59 p-type ATPase KHRBS_04015 ENOG4107ZQN disulfide bond KHRBS_04025 ENOG4105EN6 Membrane KHRBS_04035 ENOG4105EEM helicase KHRBS_04040 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KHRBS_04045 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) KHRBS_04050 ENOG4105EEQ Na H antiporter KHRBS_04065 ENOG4105E0C molybdate abc transporter KHRBS_04070 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein KHRBS_04075 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family KHRBS_04085 ENOG4107K5X Membrane-bound metal-dependent hydrolase KHRBS_04095 ENOG4105D5Q Arginine ornithine antiporter KHRBS_04105 ENOG4105DQ5 transport system permease protein KHRBS_04110 ENOG4105EHG Permease protein KHRBS_04115 ENOG4105E0A ABC, transporter KHRBS_04120 ENOG4108WMK Efflux transporter RND family MFP subunit KHRBS_04125 ENOG4105C19 ABC transporter KHRBS_04130 ENOG4107RBB ABC transporter, permease KHRBS_04140 ENOG4105F0F Oxalate decarboxylase KHRBS_04150 ENOG4106DF4 Sigma-70, region 4 KHRBS_04160 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KHRBS_04170 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein KHRBS_04175 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KHRBS_04180 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) KHRBS_04185 ENOG4105EHG Permease protein KHRBS_04190 ENOG4105E0A ABC, transporter KHRBS_04195 ENOG4108WBT adenosyltransferase KHRBS_04210 ENOG41087YS Phage shock protein A KHRBS_04225 ENOG4105ENE Histidine kinase KHRBS_04230 ENOG4105WH1 Two component transcriptional regulator luxr family KHRBS_04255 ENOG4105C9Q fumarate hydratase class II KHRBS_04260 ENOG41067SE Tetr family transcriptional regulator KHRBS_04270 ENOG4105F3H Histidine kinase KHRBS_04280 ENOG4105C0H protease KHRBS_04285 ENOG4105HUF DNA protection during starvation protein KHRBS_04290 ENOG4105E1F short-chain dehydrogenase reductase KHRBS_04305 ENOG4105E0A ABC, transporter KHRBS_04315 ENOG4105EGI Transcriptional regulator KHRBS_04330 ENOG4105C0R drug resistance transporter emrb qaca subfamily KHRBS_04365 ENOG4105CHU acetyl-coa acetyltransferase KHRBS_04370 ENOG4105C1G acyl-Coa dehydrogenase KHRBS_04375 ENOG41080E8 Transcriptional regulator, Spx MgsR family KHRBS_04380 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) KHRBS_04405 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) KHRBS_04410 ENOG4108UMI ABC transporter, permease KHRBS_04415 ENOG4105D01 (LipO)protein KHRBS_04430 ENOG4105C3K feS assembly ATPase SufC KHRBS_04435 ENOG4105JRK feS assembly protein SufD KHRBS_04440 ENOG4105C9B Cysteine desulfurase KHRBS_04445 ENOG4108UNV SUF system FeS assembly protein, NifU family KHRBS_04450 ENOG4105DIW FeS assembly protein SUFB KHRBS_04455 ENOG4105NPE arsR family transcriptional regulator KHRBS_04475 ENOG4107VFR oxidoreductase KHRBS_04480 ENOG4105PKS Excinuclease abc c subunit domain protein KHRBS_04485 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine KHRBS_04500 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component KHRBS_04505 ENOG4108KPW sugar kinase KHRBS_04510 ENOG4105FDP GntR family transcriptional regulator KHRBS_04515 ENOG4108IJ9 (ABC) transporter KHRBS_04520 ENOG4108K8S endonuclease I KHRBS_04535 ENOG4105C5R Aminotransferase KHRBS_04540 ENOG4105XRQ Xanthine dehydrogenase accessory factor KHRBS_04555 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding KHRBS_04560 ENOG4107YV9 domain protein KHRBS_04570 ENOG4105VT2 5-hydroxyisourate hydrolase KHRBS_04575 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) KHRBS_04590 ENOG4105G9B Transcriptional regulator KHRBS_04605 ENOG4105I3N Conserved Protein KHRBS_04615 ENOG4107R8B 5'-nucleotidase KHRBS_04620 ENOG4105KZD Domain of unknown function (DUF1805) KHRBS_04625 ENOG4108YTE sporulation protein YunB KHRBS_04630 ENOG4105FAA peptidase M23 KHRBS_04635 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) KHRBS_04640 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) KHRBS_04645 ENOG4105MMD transcriptional regulator KHRBS_04655 ENOG4105D4U had-superfamily hydrolase, subfamily iia KHRBS_04660 ENOG4108W5N phosphatidylglycerophosphatase a KHRBS_04670 ENOG4105D6E homoserine dehydrogenase KHRBS_04675 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) KHRBS_04680 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) KHRBS_04685 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein KHRBS_04690 ENOG41083MR nifu domain-containing protein KHRBS_04705 ENOG4105ZKE UPF0349 protein KHRBS_04720 ENOG4108YX9 iron--sulfur cluster insertion protein erpA KHRBS_04725 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 KHRBS_04745 ENOG4105CAY ferredoxin--nadp reductase KHRBS_04750 ENOG4105CEP NADH dehydrogenase KHRBS_04765 ENOG41069ER domain protein KHRBS_04775 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) KHRBS_04795 ENOG4105NIV Esterase KHRBS_04800 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase KHRBS_04805 ENOG4105E4F Isochorismate synthase KHRBS_04815 ENOG4105WQI isochorismatase KHRBS_04825 ENOG4105WQT MbtH domain protein KHRBS_04835 ENOG4105DCF alanine dehydrogenase KHRBS_04840 ENOG4108K8K Transcriptional regulator KHRBS_04875 ENOG410904N short-chain dehydrogenase reductase KHRBS_04895 ENOG4105C02 permease KHRBS_04920 ENOG4105DAP Nicotinate phosphoribosyltransferase KHRBS_04925 ENOG4105D58 Diguanylate phosphodiesterase KHRBS_04960 ENOG4105KA0 thioesterase Superfamily protein KHRBS_04965 ENOG4105KJM monovalent cation h antiporter subunit g KHRBS_04975 ENOG4105SC1 monovalent cation H antiporter subunit E KHRBS_04980 ENOG4108JPZ Monovalent cation H antiporter subunit D KHRBS_04985 ENOG4108ZE9 Monovalent cation H antiporter subunit C KHRBS_04990 ENOG4105HC0 Na H antiporter KHRBS_05015 ENOG4105UIB (ABC) transporter KHRBS_05020 ENOG4108JQ9 ABC transporter KHRBS_05025 ENOG4105DIH basic membrane KHRBS_05030 ENOG4108MRH transcriptional regulatory protein KHRBS_05045 ENOG4105KIR Thiol-disulfide oxidoreductase dcc KHRBS_05050 ENOG4105BZ4 penicillin-binding protein KHRBS_05070 ENOG4105Y38 Kinase-associated protein B KHRBS_05075 ENOG4108HGU Histidine kinase KHRBS_05080 ENOG4105C87 Aminotransferase class I and II KHRBS_05090 ENOG4108MUZ hydrolase KHRBS_05095 ENOG4108ZB6 transcriptional regulator AsnC family KHRBS_05100 ENOG4105CHM Aminotransferase KHRBS_05110 ENOG4105WG9 Conserved Protein KHRBS_05115 ENOG4107QW4 alcohol dehydrogenase KHRBS_05140 ENOG4107PBV potassium channel KHRBS_05145 ENOG4107PBV potassium channel KHRBS_05160 ENOG4105C37 (CBS) domain KHRBS_05170 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme KHRBS_05185 ENOG4105C8Q Methyl-accepting chemotaxis KHRBS_05190 ENOG4105C8Q Methyl-accepting chemotaxis KHRBS_05195 ENOG4105C8Q Methyl-accepting chemotaxis KHRBS_05200 ENOG4105C8Q Methyl-accepting chemotaxis KHRBS_05210 ENOG4105E98 transcriptional regulator DeoR family KHRBS_05215 ENOG4105DET Rhamnulokinase KHRBS_05220 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) KHRBS_05225 ENOG4105DKG l-rhamnose isomerase KHRBS_05230 ENOG4105EE0 oxidoreductase KHRBS_05240 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) KHRBS_05260 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj KHRBS_05265 ENOG4107I77 yiaA/B two helix domain KHRBS_05270 ENOG4105CZN Potassium uptake protein KHRBS_05285 ENOG4105TRT Transcriptional regulator KHRBS_05290 ENOG4105C26 Dehydrogenase KHRBS_05295 ENOG4108JB8 alcohol dehydrogenase KHRBS_05300 ENOG4108VNY MOSC domain protein KHRBS_05305 ENOG4106DF1 KHRBS_05315 ENOG4105DZ6 Band 7 protein KHRBS_05320 ENOG4105VRR gCN5-related N-acetyltransferase KHRBS_05325 ENOG4105N67 Proton-coupled thiamine transporter YuaJ KHRBS_05460 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) KHRBS_05470 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) KHRBS_05485 ENOG4108KS4 Spore coat protein KHRBS_05490 ENOG4107SBE Glycosyl transferase (Group 1 KHRBS_05505 ENOG4107SBE Glycosyl transferase (Group 1 KHRBS_05510 ENOG4108IAJ Nad-dependent epimerase dehydratase KHRBS_05530 ENOG4105E4F Isochorismate synthase KHRBS_05535 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) KHRBS_05540 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) KHRBS_05545 ENOG4108IPT Naphthoate synthase KHRBS_05550 ENOG4105CEY Amp-dependent synthetase and ligase KHRBS_05555 ENOG4105DTQ mandelate racemase muconate lactonizing KHRBS_05565 ENOG4105DIK (ABC) transporter KHRBS_05570 ENOG4105CC5 ABC transporter KHRBS_05575 ENOG4105CC5 ABC transporter KHRBS_05600 ENOG4108V2W Carbonate dehydratase KHRBS_05605 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) KHRBS_05610 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) KHRBS_05625 ENOG4108RMU ferritin dps family protein KHRBS_05640 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component KHRBS_05650 ENOG4105D2X ABC transporter substrate-binding protein KHRBS_05665 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase KHRBS_05670 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP KHRBS_05680 ENOG4105C85 amino acid KHRBS_05685 ENOG4108Z0R Transferase KHRBS_05690 ENOG4105E8V Alpha Beta Hydrolase Fold protein KHRBS_05705 ENOG4105N5T Radical SAM Protein KHRBS_05720 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family KHRBS_05725 ENOG4105DVE abc transporter atp-binding protein KHRBS_05740 ENOG4105C19 ABC transporter KHRBS_05745 ENOG4107R34 abc transporter permease protein KHRBS_05755 ENOG4105EWM Histidine kinase KHRBS_05760 ENOG4105C19 ABC transporter KHRBS_05775 ENOG410605W Major Facilitator KHRBS_05780 ENOG4105BZU Histidine kinase KHRBS_05795 ENOG41085GJ domain protein KHRBS_05805 ENOG4105I1K ABC transporter KHRBS_05810 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component KHRBS_05825 ENOG4105NTD Inherit from COG: Hydrolase KHRBS_05835 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KHRBS_05840 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KHRBS_05850 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) KHRBS_05855 ENOG4106A3M Cytochrome p-450 KHRBS_05865 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component KHRBS_05885 ENOG4105F5H Glycosyl Hydrolase Family 88 KHRBS_05900 ENOG4105MU9 integral membrane protein KHRBS_05910 ENOG4105C94 Transporter KHRBS_05915 ENOG4105CBX hi0933 family KHRBS_05930 ENOG4105YW5 deoR family transcriptional regulator KHRBS_05945 ENOG4105C7N Xanthine uracil vitamin C permease KHRBS_05950 ENOG4107QSE Dipeptidase KHRBS_05955 ENOG4105C6T cysteine synthase KHRBS_05960 ENOG4107F58 2'-5' rna ligase KHRBS_05975 ENOG4108IUM Glycogen debranching enzyme KHRBS_05980 ENOG4108V15 phosphotransferase enzyme family KHRBS_05990 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) KHRBS_05995 ENOG4105C8F Beta-lactamase domain protein KHRBS_06000 ENOG4105C6K Malic enzyme KHRBS_06015 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ KHRBS_06030 ENOG4108VDD TRNA binding domain protein KHRBS_06040 ENOG4105DFU Cell wall formation (By similarity) KHRBS_06060 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase KHRBS_06065 ENOG4105ETE Transcriptional regulator (LacI family KHRBS_06075 ENOG4105ER2 Ompa motb domain protein KHRBS_06090 ENOG4105F1V Acetoin utilization protein KHRBS_06100 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KHRBS_06110 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) KHRBS_06125 ENOG4105U5Y Transcriptional regulator KHRBS_06160 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) KHRBS_06165 ENOG4105EFZ amidohydrolase KHRBS_06175 ENOG4105D07 Signal peptide peptidase, SppA KHRBS_06180 ENOG4105VK3 rdd domain containing protein KHRBS_06190 ENOG4105KBJ sporulation protein ytfj KHRBS_06195 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) KHRBS_06205 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) KHRBS_06210 ENOG4105EPU Molybdenum cofactor synthesis domain protein KHRBS_06215 ENOG4105CDH Citrulline--aspartate ligase KHRBS_06220 ENOG4105CH7 arginosuccinase KHRBS_06235 ENOG4105E8R UPF0173 metal-dependent hydrolase KHRBS_06240 ENOG4108KSA LysR family transcriptional regulator KHRBS_06245 ENOG4108XSB acetyltransferase, (GNAT) family KHRBS_06270 ENOG4105CDA abc transporter atp-binding protein KHRBS_06275 ENOG4105DEN Luciferase family KHRBS_06295 ENOG4105CH2 amidohydrolase KHRBS_06300 ENOG410635A Membrane KHRBS_06320 ENOG4105SFS phosphoesterase RecJ domain protein KHRBS_06325 ENOG4106EVM KHRBS_06350 ENOG4108IEY Carboxyl transferase domain KHRBS_06360 ENOG4105CTQ phosphohexokinase KHRBS_06365 ENOG4105CA9 Pyruvate kinase KHRBS_06370 ENOG4105FS0 cytoplasmic membrane protein KHRBS_06375 ENOG4108REF Sporulation integral membrane protein ytvi KHRBS_06385 ENOG4105BZN citrate synthase KHRBS_06390 ENOG4108HMX isocitrate dehydrogenase (NADP) KHRBS_06395 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KHRBS_06400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KHRBS_06410 ENOG4105C2M dna polymerase I KHRBS_06415 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) KHRBS_06430 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) KHRBS_06435 ENOG4105CV8 reductase KHRBS_06440 ENOG4105F27 Major Facilitator KHRBS_06445 ENOG4105KVH Transcriptional regulator KHRBS_06450 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KHRBS_06455 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) KHRBS_06460 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) KHRBS_06480 ENOG4108TDW sporulation protein YtxC KHRBS_06490 ENOG4105U0R haloacid dehalogenase-like hydrolase KHRBS_06500 ENOG4105DY9 regulatoR KHRBS_06510 ENOG41067MG lrgb family KHRBS_06520 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) KHRBS_06525 ENOG4105VJV 50s ribosomal protein L35 KHRBS_06530 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) KHRBS_06535 ENOG410696E Membrane KHRBS_06545 ENOG4105CN9 Peptidase m42 family protein KHRBS_06550 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase KHRBS_06560 ENOG4105EF1 ribulokinase KHRBS_06565 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase KHRBS_06575 ENOG4108MDK Dehydrogenase KHRBS_06590 ENOG4105DRS transport system, permease KHRBS_06595 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KHRBS_06610 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KHRBS_06615 ENOG4105CQB FAD linked oxidase domain protein KHRBS_06625 ENOG41067MF small acid-soluble spore protein KHRBS_06630 ENOG4108RWN rrna methyltransferase KHRBS_06640 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) KHRBS_06650 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KHRBS_06665 ENOG4105DCG PHP domain protein KHRBS_06680 ENOG4105CEY Amp-dependent synthetase and ligase KHRBS_06685 ENOG4107Z3H Transcriptional regulator, TetR family KHRBS_06690 ENOG41060WC Enoyl-CoA hydratase KHRBS_06695 ENOG4105BZJ Electron transfer flavoprotein KHRBS_06700 ENOG4105C10 Electron transfer flavoprotein KHRBS_06705 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KHRBS_06710 ENOG4105K63 Thioredoxin KHRBS_06715 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) KHRBS_06720 ENOG4105CFH Aspartokinase KHRBS_06735 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit KHRBS_06745 ENOG4105E33 succinate dehydrogenase KHRBS_06755 ENOG4105PFC Transcriptional regulator KHRBS_06760 ENOG41067TZ transcriptional regulator, MarR family KHRBS_06765 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) KHRBS_06770 ENOG4108XJQ germination protein KHRBS_06775 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) KHRBS_06780 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) KHRBS_06785 ENOG4105M59 Phosphodiesterase, mj0936 family KHRBS_06795 ENOG4107KM7 Heat induced stress protein YflT KHRBS_06805 ENOG4105I4A GCN5-related N-acetyltransferase KHRBS_06815 ENOG4105C7K acetolactate synthase KHRBS_06820 ENOG4108ZP8 Acetolactate synthase small subunit KHRBS_06825 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase KHRBS_06830 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) KHRBS_06835 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KHRBS_06840 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KHRBS_06845 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KHRBS_06855 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation KHRBS_06860 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) KHRBS_06865 ENOG4108IUQ atp-dependent protease KHRBS_06870 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) KHRBS_06875 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) KHRBS_06885 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) KHRBS_06895 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) KHRBS_06905 ENOG4105D52 delta-aminolevulinic acid dehydratase KHRBS_06910 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase KHRBS_06935 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase KHRBS_06940 ENOG4106A3R peptidase KHRBS_06950 ENOG4108Z03 MAF-like protein KHRBS_06960 ENOG4105DFF Rod shape-determining protein mreb KHRBS_06965 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) KHRBS_06970 ENOG4105YHC Rod shape-determining protein MreD KHRBS_06975 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) KHRBS_06980 ENOG4107QMS site-determining protein KHRBS_06995 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) KHRBS_07000 ENOG4105X36 (ribosomal) protein KHRBS_07005 ENOG4105K46 50S ribosomal protein l27 KHRBS_07015 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control KHRBS_07020 ENOG41090I5 UPF0735 ACT domain-containing protein KHRBS_07025 ENOG4105CQC Prephenate dehydratase KHRBS_07040 ENOG4108IYU L-aspartate oxidase KHRBS_07050 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) KHRBS_07055 ENOG4106678 morphogenetic protein associated with SpoVID KHRBS_07065 ENOG4105CDY transcriptional regulatory protein KHRBS_07070 ENOG4105BZG amino acid carrier protein KHRBS_07095 ENOG4105CK5 oxidoreductase KHRBS_07110 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) KHRBS_07115 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) KHRBS_07120 ENOG41061AI Protein of unknown function (DUF2905) KHRBS_07125 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) KHRBS_07130 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) KHRBS_07135 ENOG4105VIE preprotein translocase, subunit YajC KHRBS_07140 ENOG4105NAP KHRBS_07145 ENOG4108QG2 Membrane KHRBS_07150 ENOG4105CKP Polysaccharide Biosynthesis Protein KHRBS_07160 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) KHRBS_07170 ENOG41067VP Protein of unknown function (DUF1049) KHRBS_07175 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) KHRBS_07180 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) KHRBS_07185 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) KHRBS_07195 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KHRBS_07205 ENOG4105CUT histidyl-tRNA synthetase KHRBS_07210 ENOG4105C9M aspartyl-trna synthetase KHRBS_07225 ENOG4105D1H recombination factor protein RarA KHRBS_07235 ENOG4105C3J Cysteine desulfurase KHRBS_07240 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) KHRBS_07250 ENOG4105C7H Helicase, RecD TraA family KHRBS_07260 ENOG41060CR KHRBS_07275 ENOG4105EAD ABC transporter KHRBS_07280 ENOG4105CT1 (ABC) transporter KHRBS_07285 ENOG4105CDA abc transporter atp-binding protein KHRBS_07290 ENOG4105C02 permease KHRBS_07295 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KHRBS_07300 ENOG4105VBH UPF0297 protein KHRBS_07305 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) KHRBS_07310 ENOG4105VPH UPF0473 protein KHRBS_07315 ENOG4105HHA aminodeoxychorismate lyase KHRBS_07320 ENOG4108VQJ O-methyltransferase KHRBS_07325 ENOG4105XYU peptidase (U32 family) KHRBS_07330 ENOG4105CFP Peptidase U32 KHRBS_07335 ENOG4105DBI uridine monophosphokinase KHRBS_07340 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) KHRBS_07360 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) KHRBS_07375 ENOG4105C28 cystathionine KHRBS_07390 ENOG4108JB9 formate dehydrogenase KHRBS_07395 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) KHRBS_07400 ENOG4105TMB Formate nitrite transporter KHRBS_07420 ENOG41082JN Transcriptional regulator KHRBS_07425 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KHRBS_07430 ENOG4105WDR KHRBS_07435 ENOG4105EXC Acyl-transferase KHRBS_07440 ENOG4108P49 AntiSigma factor KHRBS_07450 ENOG4108NGU Transcriptional regulator KHRBS_07455 ENOG4105N14 lysine exporter protein LysE YggA KHRBS_07460 ENOG4105C85 amino acid KHRBS_07465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family KHRBS_07470 ENOG4105YHU PTS system KHRBS_07475 ENOG4108IQ3 PTS system KHRBS_07490 ENOG4108HKT sucrose-6-phosphate hydrolase KHRBS_07495 ENOG4108Z0Z intracellular protease Pfpi family KHRBS_07500 ENOG4105DQ4 alcohol dehydrogenase KHRBS_07510 ENOG4105VUF Transcriptional regulator KHRBS_07525 ENOG4105E2A Dehydrogenase KHRBS_07530 ENOG4105PGS Spore coat protein KHRBS_07540 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase KHRBS_07545 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein KHRBS_07550 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein KHRBS_07555 ENOG4108VQT Alpha beta hydrolase fold protein KHRBS_07560 ENOG4105X5K response regulator receiver protein KHRBS_07565 ENOG41083Q9 chitosanase KHRBS_07570 ENOG4105C7F AcnD-accessory protein PrpF KHRBS_07575 ENOG4108KAM Transcriptional regulator KHRBS_07585 ENOG4105CPC Aldo Keto reductase KHRBS_07590 ENOG410904A RNA polymerase KHRBS_07595 ENOG4108MEK Metal-binding protein YodA KHRBS_07610 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) KHRBS_07620 ENOG4105EA8 2-Nitropropane dioxygenase KHRBS_07625 ENOG41075D4 Aminoglycoside 6-adenylyltransferase KHRBS_07660 ENOG41067XF inhibitor KHRBS_07665 ENOG4108ZRZ Transcriptional regulator (AsnC family) KHRBS_07700 ENOG4105PGM cation diffusion facilitator family transporter KHRBS_07705 ENOG4105H3G oxidoreductase KHRBS_07725 ENOG4105C37 (CBS) domain KHRBS_07755 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein KHRBS_07760 ENOG4105XTG Pfam:DUF156 KHRBS_07770 ENOG4105VFE sira family KHRBS_07780 ENOG4107TPS domain protein KHRBS_07790 ENOG41087NI Sulfite exporter TauE/SafE KHRBS_07795 ENOG4105D3P Mannan endo-1,4-beta-mannosidase KHRBS_07815 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHRBS_07820 ENOG4105WFK nuclease KHRBS_07835 ENOG41080BT SNARE associated Golgi KHRBS_07840 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KHRBS_07860 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase KHRBS_07870 ENOG4105E2X shikimate dehydrogenase KHRBS_07875 ENOG410812S Rna-binding protein KHRBS_07880 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) KHRBS_07885 ENOG4108WF2 Metal Dependent Phosphohydrolase KHRBS_07895 ENOG4108D32 Methyltransferase KHRBS_07910 ENOG4108UK2 deaminase KHRBS_07915 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 KHRBS_07925 ENOG4105TQK DNA polymerase iii, delta' subunit KHRBS_07930 ENOG41082YS Binds directly to 16S ribosomal RNA KHRBS_07940 ENOG4108ZRV stage ii sporulation protein p KHRBS_07955 ENOG4105CSA Coproporphyrinogen iii oxidase KHRBS_07960 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) KHRBS_07965 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ KHRBS_07970 ENOG4105CFG Acts as a chaperone (By similarity) KHRBS_07980 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) KHRBS_07985 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) KHRBS_07990 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KHRBS_08005 ENOG4105KTH gatB Yqey KHRBS_08025 ENOG41068P3 sporulation protein YqfC KHRBS_08035 ENOG4105C9A Phoh family KHRBS_08045 ENOG4105CTJ Metal Dependent Phosphohydrolase KHRBS_08050 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) KHRBS_08055 ENOG4107YR5 Diacylglycerol kinase KHRBS_08060 ENOG4105KG3 cytidine deaminase KHRBS_08065 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) KHRBS_08075 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) KHRBS_08080 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit KHRBS_08085 ENOG4105C38 Glycyl-tRNA synthetase beta subunit KHRBS_08095 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) KHRBS_08100 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 KHRBS_08105 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) KHRBS_08110 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHRBS_08125 ENOG4105EGD dinuclear metal center protein, YbgI family KHRBS_08130 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) KHRBS_08145 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) KHRBS_08150 ENOG41069ZM Protein of unknown function (DUF2624) KHRBS_08155 ENOG4108JYZ YitT family KHRBS_08160 ENOG4105N80 Ferric uptake regulator, Fur family KHRBS_08165 ENOG4108U5J '-nucleotidase KHRBS_08170 ENOG41063Y9 KHRBS_08175 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) KHRBS_08195 ENOG4105SXS Protein of unknown function (DUF456) KHRBS_08200 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KHRBS_08210 ENOG4107RF6 penicillin-binding protein KHRBS_08215 ENOG4105CVA phosphate KHRBS_08220 ENOG4105C8U phosphate abc transporter KHRBS_08225 ENOG4105E2Z phosphate ABC transporter (Permease KHRBS_08230 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KHRBS_08235 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KHRBS_08240 ENOG41068DG YceG-like family KHRBS_08260 ENOG4105WDJ 50S ribosomal protein L33 KHRBS_08265 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase KHRBS_08315 ENOG4105C5X domain protein KHRBS_08340 ENOG4105C37 (CBS) domain KHRBS_08350 ENOG41080XP Cbs domain KHRBS_08410 ENOG4105VFR signal peptidase KHRBS_08420 ENOG4108IMY Transcriptional regulator KHRBS_08440 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KHRBS_08445 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor KHRBS_08455 ENOG4105WZW rhodanese family KHRBS_08460 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) KHRBS_08465 ENOG4105KST dependent repressor KHRBS_08480 ENOG4105CBJ Metal-dependent enzyme KHRBS_08490 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) KHRBS_08495 ENOG4105DC7 peptidase M24 KHRBS_08500 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) KHRBS_08510 ENOG4105CD2 stage iii sporulation protein aa KHRBS_08515 ENOG4105KR5 Stage iii sporulation protein KHRBS_08520 ENOG4108CQH stage III sporulation protein AC KHRBS_08525 ENOG4105KQ4 Stage iii sporulation protein ad KHRBS_08535 ENOG410644B Stage III sporulation protein af KHRBS_08555 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KHRBS_08560 ENOG4108ZSR alkaline shock protein KHRBS_08565 ENOG4105M7K Involved in the transcription termination process (By similarity) KHRBS_08570 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) KHRBS_08575 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KHRBS_08580 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KHRBS_08585 ENOG4105CTB Polyprenyl synthetase KHRBS_08595 ENOG4105DX0 Hemolysin A KHRBS_08600 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) KHRBS_08605 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) KHRBS_08620 ENOG4107QQR Sporulation KHRBS_08630 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KHRBS_08645 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KHRBS_08660 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KHRBS_08665 ENOG4105C1G acyl-Coa dehydrogenase KHRBS_08675 ENOG4105DXD 2-methylcitrate dehydratase KHRBS_08680 ENOG4105CR4 methylisocitrate lyase KHRBS_08685 ENOG4106CCJ Protein of unknown function (DUF2627) KHRBS_08690 ENOG4108JUB Transcriptional regulator KHRBS_08700 ENOG4107RDP Dehydrogenase KHRBS_08705 ENOG4105CKM Branched-chain carboxylic acid kinase KHRBS_08720 ENOG4105CPP Dehydrogenase, E1 component KHRBS_08725 ENOG4105C7S Dehydrogenase KHRBS_08740 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) KHRBS_08745 ENOG4108Y6J UPF0403 protein KHRBS_08750 ENOG4108HW3 (ABC) transporter KHRBS_08755 ENOG4105E5Q amino acid AbC transporter KHRBS_08760 ENOG4105CDA abc transporter atp-binding protein KHRBS_08765 ENOG4108QEG Membrane KHRBS_08770 ENOG4108VZI ErfK ybiS ycfS ynhG family protein KHRBS_08780 ENOG4108ZVT methylmalonyl-coA epimerase KHRBS_08785 ENOG4108HNZ carboxyl transferase KHRBS_08790 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KHRBS_08795 ENOG4108NA0 Uncharacterized conserved protein (COG2071) KHRBS_08800 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) KHRBS_08810 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KHRBS_08820 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase KHRBS_08825 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) KHRBS_08830 ENOG410861F 50S ribosomal protein L33 KHRBS_08840 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KHRBS_08850 ENOG4105II7 pyrroline-5-carboxylate reductase KHRBS_08855 ENOG41069FQ Metallo-beta-lactamase superfamily KHRBS_08860 ENOG4108IXY short-chain dehydrogenase reductase KHRBS_08875 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase KHRBS_08905 ENOG4108XET gCN5-related N-acetyltransferase KHRBS_08910 ENOG4105KAC Antibiotic biosynthesis monooxygenase KHRBS_08920 ENOG4106HZJ KHRBS_08940 ENOG4105CPC Aldo Keto reductase KHRBS_08950 ENOG4108YZ4 nudix hydrolase KHRBS_08960 ENOG4108IMY Transcriptional regulator KHRBS_08970 ENOG4108IJ0 Aspartate ammonia-lyase KHRBS_08975 ENOG4105DFD Na H antiporter KHRBS_08990 ENOG4105MZ9 stage II sporulation protein m KHRBS_08995 ENOG4105I3K Ferric uptake regulator, Fur family KHRBS_09005 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KHRBS_09010 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) KHRBS_09015 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) KHRBS_09025 ENOG41082AN stage II sporulation protein KHRBS_09030 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KHRBS_09035 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHRBS_09050 ENOG41090VF Stage v sporulation protein ac KHRBS_09055 ENOG4105CZ3 stage V sporulation protein ad KHRBS_09065 ENOG4105G6R Stage v sporulation protein ae KHRBS_09075 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) KHRBS_09080 ENOG4105PTM secreted protein KHRBS_09085 ENOG4107ZE5 PPIases accelerate the folding of proteins KHRBS_09105 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) KHRBS_09110 ENOG4105C3F Signal peptidase i KHRBS_09120 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) KHRBS_09125 ENOG4108R6K riboflavin synthase, subunit alpha KHRBS_09130 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) KHRBS_09135 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) KHRBS_09150 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) KHRBS_09155 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) KHRBS_09165 ENOG4105DZ1 carboxypeptidase KHRBS_09170 ENOG4108JIC nucleoside recognition domain protein KHRBS_09180 ENOG4105FE9 pseudouridine synthase KHRBS_09190 ENOG4107TWT Cytochrome c biogenesis protein KHRBS_09195 ENOG4105CRE cytochrome C KHRBS_09200 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KHRBS_09205 ENOG4105BZU Histidine kinase KHRBS_09220 ENOG4105FF2 Type I DHQase KHRBS_09225 ENOG4108JQ1 Dehydrogenase KHRBS_09230 ENOG4108SAX Membrane KHRBS_09240 ENOG4105T7X KHRBS_09245 ENOG4105C9U ATP-dependent DNA helicase RecQ KHRBS_09250 ENOG4105I7S Abortive infection protein KHRBS_09265 ENOG4107RGJ metallophosphoesterase KHRBS_09280 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase KHRBS_09285 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) KHRBS_09295 ENOG4105MSI germination protein ypeb KHRBS_09310 ENOG4105CAT Cytidine monophosphate kinase KHRBS_09315 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) KHRBS_09335 ENOG4105S2F KHRBS_09340 ENOG41065D1 KHRBS_09345 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) KHRBS_09350 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase KHRBS_09365 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) KHRBS_09370 ENOG4105K70 DNA-binding protein KHRBS_09375 ENOG4105EUJ GTP cyclohydrolase i KHRBS_09390 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KHRBS_09395 ENOG4105EAH synthase KHRBS_09400 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) KHRBS_09410 ENOG4105BZU Histidine kinase KHRBS_09415 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase KHRBS_09420 ENOG4105D49 3-dehydroquinate synthase KHRBS_09425 ENOG4105KHN chorismate mutase KHRBS_09430 ENOG4105CRQ synthase (Component I) KHRBS_09435 ENOG4108I0Q anthranilate phosphoribosyltransferase KHRBS_09445 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase KHRBS_09450 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) KHRBS_09460 ENOG4105CIH Imidazole acetol-phosphate transaminase KHRBS_09470 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase KHRBS_09475 ENOG41068YB TPR repeat-containing protein KHRBS_09495 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) KHRBS_09520 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase KHRBS_09525 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) KHRBS_09530 ENOG4108Z5K methylglyoxal synthase KHRBS_09535 ENOG4105FJR Lmbe family KHRBS_09540 ENOG4105CPK Glycosyl transferase (Group 1 KHRBS_09545 ENOG4105DJ0 Poly(A) Polymerase KHRBS_09555 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) KHRBS_09560 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) KHRBS_09565 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) KHRBS_09575 ENOG4105YAC KHRBS_09585 ENOG4105CHM Aminotransferase KHRBS_09590 ENOG4105C5S asparaginyl-tRNA synthetase KHRBS_09600 ENOG4105CSM endonuclease III KHRBS_09610 ENOG4105BZ4 penicillin-binding protein KHRBS_09660 ENOG4108I5C dEAD DEAH box helicase KHRBS_09665 ENOG4107X2U Inherit from COG: Exonuclease-like protein KHRBS_09675 ENOG4108UKS UPF0398 protein KHRBS_09705 ENOG4105DVT helicase KHRBS_09710 ENOG4105CHR reductase KHRBS_09720 ENOG4108M60 Transcriptional regulator KHRBS_09725 ENOG4105D7K pfkb domain protein KHRBS_09730 ENOG4108UHU Aldolase KHRBS_09735 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) KHRBS_09740 ENOG4105CTD carboxy-peptidase KHRBS_09745 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) KHRBS_09755 ENOG41065KQ synthase KHRBS_09795 ENOG41081VK Ribonuclease KHRBS_09835 ENOG4105CVG Homoserine O-transsuccinylase KHRBS_09840 ENOG4108V06 Glutathione peroxidase KHRBS_09855 ENOG4105C01 Dihydroxy-acid dehydratase KHRBS_09860 ENOG4108Y6J UPF0403 protein KHRBS_09865 ENOG4107YX5 Pfam:DUF548 KHRBS_09880 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) KHRBS_09885 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) KHRBS_09895 ENOG4108UT2 hemolysin iii KHRBS_09905 ENOG4105C7B Threonine dehydratase KHRBS_09920 ENOG4108KF3 Electron transport protein SCO1 SenC KHRBS_09925 ENOG41090WU lipolytic protein G-D-S-L family KHRBS_09930 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) KHRBS_09950 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) KHRBS_09955 ENOG4105E0X reductase KHRBS_09960 ENOG4105C5E polysaccharide biosynthesis protein KHRBS_09965 ENOG4107T32 3-phytase (EC 3.1.3.8) KHRBS_10005 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KHRBS_10020 ENOG4107S4Y M20 DapE family protein YgeY KHRBS_10025 ENOG4108TSC N-acetyltransferase KHRBS_10065 ENOG4106BHF KHRBS_10215 ENOG41068G1 KHRBS_10325 ENOG4105K70 DNA-binding protein KHRBS_10330 ENOG4105ZUG KHRBS_10340 ENOG4105ZUG KHRBS_10365 ENOG4108NE4 KHRBS_10480 ENOG4107D0N KHRBS_10625 ENOG41079CX KHRBS_10630 ENOG4108J9Q DNA ligase KHRBS_10635 ENOG4108RAV Conserved protein KHRBS_10735 ENOG4106210 phosphatase activity KHRBS_10840 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) KHRBS_10855 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KHRBS_10885 ENOG4106ITI Glutaredoxin KHRBS_10900 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) KHRBS_10925 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) KHRBS_10930 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) KHRBS_11010 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) KHRBS_11015 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) KHRBS_11030 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein KHRBS_11065 ENOG410841Q phosphoesterase PA-phosphatase related protein KHRBS_11070 ENOG4106Z5R KHRBS_11080 ENOG4105D3A purine nucleoside phosphorylase DeoD-type KHRBS_11085 ENOG4108VXD carboxy-peptidase KHRBS_11120 ENOG4105FBA Phospholipase Carboxylesterase KHRBS_11135 ENOG41090U3 tautomerase KHRBS_11140 ENOG4105C6Z Gluconate KHRBS_11155 ENOG4105FR1 rard protein KHRBS_11175 ENOG4106SCS STAS domain KHRBS_11190 ENOG41087PP glycosyltransferase MGT family KHRBS_11195 ENOG4105K4H Nlp p60 protein KHRBS_11205 ENOG4105GMT ATPase associated with various cellular activities aaa_5 KHRBS_11210 ENOG4107T89 von Willebrand factor, type A KHRBS_11220 ENOG4105C7S Dehydrogenase KHRBS_11225 ENOG4105C09 Bile acid KHRBS_11230 ENOG4105C8J )-transporter KHRBS_11235 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KHRBS_11245 ENOG4105C26 Dehydrogenase KHRBS_11290 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KHRBS_11305 ENOG4105C9U ATP-dependent DNA helicase RecQ KHRBS_11310 ENOG41069ER domain protein KHRBS_11315 ENOG4108S01 response regulator KHRBS_11325 ENOG4105ECK Fatty Acid Desaturase KHRBS_11345 ENOG4108SJC Membrane KHRBS_11355 ENOG4105KTU Transcriptional regulator, arsr family KHRBS_11365 ENOG4105D29 Helix-turn-helix type 11 domain protein KHRBS_11375 ENOG4108W8B Beta-lactamase domain protein KHRBS_11385 ENOG4108HJF gCN5-related N-acetyltransferase KHRBS_11390 ENOG4105FTV AraC Family Transcriptional Regulator KHRBS_11395 ENOG4108Z7R Chaperone CsaA KHRBS_11415 ENOG4106ANW SMI1_KNR4 KHRBS_11430 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component KHRBS_11435 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component KHRBS_11455 ENOG4105ETE Transcriptional regulator (LacI family KHRBS_11460 ENOG4105D3P Mannan endo-1,4-beta-mannosidase KHRBS_11485 ENOG4108IMY Transcriptional regulator KHRBS_11490 ENOG4105YB8 TM2 domain containing protein KHRBS_11500 ENOG4107T94 Endo-14-beta-xylanase KHRBS_11505 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) KHRBS_11530 ENOG4108J4B Beta-lactamase KHRBS_11535 ENOG4108V4B ThiJ pfpI KHRBS_11545 ENOG4108Q5Y Membrane KHRBS_11555 ENOG4105NX3 Membrane KHRBS_11560 ENOG4105VMP Transcriptional regulator KHRBS_11570 ENOG41073R8 VanW family KHRBS_11590 ENOG4105F0F Oxalate decarboxylase KHRBS_11600 ENOG4108RAV Conserved protein KHRBS_11605 ENOG4108NR7 pectate lyase KHRBS_11610 ENOG4105XPP Protein of unknown function (DUF1275) KHRBS_11615 ENOG4108YQE rare lipoprotein a KHRBS_11625 ENOG4105EC8 Methyl-accepting chemotaxis KHRBS_11655 ENOG4108M3J Dehydrogenase KHRBS_11660 ENOG4107U6E carbohydrate kinase FGGY KHRBS_11665 ENOG4105IE8 Alpha-ketoglutarate permease KHRBS_11675 ENOG4105CJ1 ABC, transporter KHRBS_11690 ENOG41068WN KHRBS_11695 ENOG4108UB7 KHRBS_11715 ENOG4105II7 pyrroline-5-carboxylate reductase KHRBS_11720 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KHRBS_11725 ENOG4105C5Q Transcriptional regulator KHRBS_11735 ENOG4105BZ8 glutamate synthase KHRBS_11740 ENOG4105CB2 alcohol dehydrogenase KHRBS_11745 ENOG4105SKE transcriptional Regulator LysR family KHRBS_11750 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KHRBS_11775 ENOG4107QJQ Mate efflux family protein KHRBS_11780 ENOG4108N2V aldose 1-epimerase KHRBS_11785 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family KHRBS_11790 ENOG4105C0W non-ribosomal peptide synthetase KHRBS_11800 ENOG4105C0W non-ribosomal peptide synthetase KHRBS_11815 ENOG4106U2H Protein of unknown function (DUF1360) KHRBS_11820 ENOG4105F32 YngK protein KHRBS_11835 ENOG4105C1G acyl-Coa dehydrogenase KHRBS_11840 ENOG4105CEY Amp-dependent synthetase and ligase KHRBS_11845 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KHRBS_11850 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit KHRBS_11855 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase KHRBS_11860 ENOG4105E39 Enoyl-CoA hydratase KHRBS_11875 ENOG4107T5V SNARE associated Golgi KHRBS_11880 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KHRBS_11890 ENOG4107SYN Glycosyl hydrolases family 43 KHRBS_11895 ENOG4108MYR Secreted protein KHRBS_11930 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KHRBS_11935 ENOG4105K4P CoA-binding domain protein KHRBS_11940 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) KHRBS_11945 ENOG4105W8X HesB YadR YfhF-family protein KHRBS_11950 ENOG4105MI2 KHRBS_11960 ENOG41067CD Small, acid-soluble spore protein Tlp KHRBS_11975 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KHRBS_11990 ENOG4107DZX Small, acid-soluble spore protein P KHRBS_12035 ENOG4105CV1 Transketolase (EC 2.2.1.1) KHRBS_12040 ENOG4105VPS UPF0291 protein KHRBS_12055 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) KHRBS_12065 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) KHRBS_12075 ENOG4105K7W phage-related replication protein KHRBS_12100 ENOG4108NHD germination protein KHRBS_12105 ENOG4108Q8B Spore germination protein KHRBS_12180 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) KHRBS_12195 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KHRBS_12200 ENOG4105C54 Major Facilitator superfamily KHRBS_12205 ENOG4107Y9E nuclease KHRBS_12210 ENOG4105CMG Carbohydrate kinase KHRBS_12215 ENOG4105C93 Xylose Isomerase KHRBS_12220 ENOG4105E2R ROK family KHRBS_12225 ENOG4105DSG hydrolase family 43 KHRBS_12230 ENOG4105CT4 transporter KHRBS_12235 ENOG410907G KHRBS_12260 ENOG4107NTZ KHRBS_12310 ENOG4105C5F glutamine synthetase KHRBS_12315 ENOG4105KV4 Transcriptional regulator KHRBS_12320 ENOG4105CXI aluminum resistance protein KHRBS_12325 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) KHRBS_12335 ENOG4106F1P AAA ATPase, central domain protein KHRBS_12340 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KHRBS_12345 ENOG4105U6W MutT NUDIX family protein KHRBS_12350 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KHRBS_12360 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) KHRBS_12375 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) KHRBS_12380 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) KHRBS_12400 ENOG410814C multidrug resistance protein KHRBS_12405 ENOG4108X3M OsmC Ohr family protein KHRBS_12410 ENOG4105K7W phage-related replication protein KHRBS_12420 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KHRBS_12445 ENOG4105C0W non-ribosomal peptide synthetase KHRBS_12455 ENOG4107SQU synthase KHRBS_12465 ENOG4108KQ6 Enoyl-CoA hydratase KHRBS_12470 ENOG4108MGH Enoyl-CoA hydratase KHRBS_12475 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase KHRBS_12480 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase KHRBS_12485 ENOG41062T2 Acyl carrier protein KHRBS_12490 ENOG4107QKG PfaD family KHRBS_12505 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KHRBS_12515 ENOG4108151 Beta-lactamase domain protein KHRBS_12520 ENOG4105W1N transcriptional regulator KHRBS_12540 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) KHRBS_12545 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) KHRBS_12560 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KHRBS_12565 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KHRBS_12575 ENOG4105MCT stage V sporulation protein S KHRBS_12580 ENOG4105D48 metallophosphoesterase KHRBS_12585 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) KHRBS_12590 ENOG4108A04 Beta-lactamase KHRBS_12605 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase KHRBS_12620 ENOG4105XZV Protein of unknown function (DUF3243) KHRBS_12625 ENOG4108RKS Short-chain dehydrogenase reductase Sdr KHRBS_12645 ENOG4105FDP GntR family transcriptional regulator KHRBS_12660 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit KHRBS_12670 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KHRBS_12680 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) KHRBS_12690 ENOG4105E35 Dipicolinate synthase subunit A KHRBS_12715 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) KHRBS_12720 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) KHRBS_12725 ENOG4105DTN riboflavin biosynthesis protein ribF KHRBS_12730 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) KHRBS_12735 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) KHRBS_12740 ENOG4105W7A Protein of unknown function (DUF503) KHRBS_12745 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) KHRBS_12750 ENOG4105VHM ribosomal protein KHRBS_12755 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination KHRBS_12760 ENOG4105CHV Transcription elongation factor NusA KHRBS_12765 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) KHRBS_12770 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) KHRBS_12775 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) KHRBS_12780 ENOG4105DZP Membrane-associated zinc metalloprotease KHRBS_12790 ENOG4105KNE Phosphatidate cytidylyltransferase KHRBS_12795 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) KHRBS_12800 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) KHRBS_12810 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) KHRBS_12825 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHRBS_12840 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis KHRBS_12845 ENOG4105CBS Chea signal transduction histidine kinase KHRBS_12850 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) KHRBS_12860 ENOG4105FZW flagellar biosynthesis regulator FlhF KHRBS_12865 ENOG4105D7B Flagellar biosynthesis protein flha KHRBS_12870 ENOG4105D00 flagellar biosynthetic protein flhB KHRBS_12875 ENOG4105D19 Role in flagellar biosynthesis (By similarity) KHRBS_12880 ENOG4105VS8 Flagellar biosynthetic protein fliq KHRBS_12885 ENOG4105CN7 Flagellar biosynthetic protein FliP KHRBS_12895 ENOG4107YTP response regulator receiver protein KHRBS_12900 ENOG4105DD5 Flagellar motor switch protein KHRBS_12915 ENOG41068WV flagellar FlbD family protein KHRBS_12920 ENOG4108JQA flagellar KHRBS_12925 ENOG410822I Flagellar hook capping protein KHRBS_12930 ENOG410696Y Flagellar hook-length control protein KHRBS_12940 ENOG4106YF4 Flagellar biosynthesis chaperone KHRBS_12960 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) KHRBS_12965 ENOG4105VQ0 flagellar hook-basal body complex protein fliE KHRBS_12970 ENOG4108ZC9 flagellar basal-body rod protein flgc KHRBS_12975 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) KHRBS_12985 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) KHRBS_12990 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) KHRBS_12995 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KHRBS_13005 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) KHRBS_13010 ENOG4105C79 DNA protecting protein DprA KHRBS_13015 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha KHRBS_13020 ENOG4105CMV Succinyl-CoA synthetase subunit beta KHRBS_13025 ENOG4105VM1 flagellar KHRBS_13035 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KHRBS_13040 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) KHRBS_13045 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) KHRBS_13050 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) KHRBS_13055 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) KHRBS_13065 ENOG4108BW8 UPF0109 protein KHRBS_13070 ENOG4105K5M 30s ribosomal protein S16 KHRBS_13080 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) KHRBS_13090 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) KHRBS_13100 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) KHRBS_13105 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) KHRBS_13110 ENOG4105CHR reductase KHRBS_13125 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) KHRBS_13130 ENOG4105CB5 ATP-dependent DNA helicase recG KHRBS_13135 ENOG4105EJQ L-serine dehydratase KHRBS_13145 ENOG4105DP4 dak2 domain fusion protein ylov KHRBS_13150 ENOG4108ZAA Alkaline-shock protein KHRBS_13155 ENOG4105VB9 50S ribosomal protein l28 KHRBS_13165 ENOG4105FJ0 thiamine KHRBS_13170 ENOG4105DJV ribulose-phosphate 3-epimerase KHRBS_13175 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) KHRBS_13180 ENOG4105D9P serine threonine protein kinase KHRBS_13185 ENOG4108ZF3 Phosphatase KHRBS_13190 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs KHRBS_13195 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B KHRBS_13200 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) KHRBS_13205 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KHRBS_13225 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) KHRBS_13230 ENOG4105KC4 UPF0296 protein KHRBS_13235 ENOG4105DSJ YicC domain protein KHRBS_13245 ENOG4105F23 Fibronectin-binding protein KHRBS_13255 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein KHRBS_13260 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KHRBS_13265 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) KHRBS_13270 ENOG4107S4M Sulfate adenylate transferase KHRBS_13280 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) KHRBS_13285 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) KHRBS_13295 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) KHRBS_13300 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) KHRBS_13305 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain KHRBS_13310 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KHRBS_13320 ENOG4105CXT aspartate transcarbamylase KHRBS_13330 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) KHRBS_13335 ENOG4105C34 Pseudouridine synthase KHRBS_13340 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) KHRBS_13350 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) KHRBS_13365 ENOG41067XK integral membrane protein KHRBS_13370 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) KHRBS_13375 ENOG4105DFA alanine racemase domain protein KHRBS_13380 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase KHRBS_13385 ENOG4105WR5 sporulation protein, YlmC YmxH family KHRBS_13395 ENOG4105DKW ABC transporter KHRBS_13420 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) KHRBS_13425 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) KHRBS_13430 ENOG4105K67 small basic protein KHRBS_13440 ENOG4108R2U division initiation protein KHRBS_13445 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) KHRBS_13450 ENOG4105D4A Cell wall formation (By similarity) KHRBS_13455 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) KHRBS_13460 ENOG4105CNI cell division protein FtsW KHRBS_13465 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) KHRBS_13470 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) KHRBS_13480 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) KHRBS_13490 ENOG4105CJN penicillin-binding protein KHRBS_13500 ENOG4105CJN penicillin-binding protein KHRBS_13510 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) KHRBS_13515 ENOG4108V6E Cell division protein mraZ KHRBS_13540 ENOG41067VY 50S ribosomal protein L32 KHRBS_13545 ENOG4105KNH Nucleic acid-binding protein KHRBS_13555 ENOG4105CDE UPF0348 protein KHRBS_13560 ENOG41063PX domain protein KHRBS_13565 ENOG4105D78 K07001 NTE family protein KHRBS_13570 ENOG4105H20 Sporulation integral membrane protein YlbJ KHRBS_13575 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) KHRBS_13580 ENOG4106H78 methyltransferase KHRBS_13585 ENOG4105WUC UPF0298 protein KHRBS_13605 ENOG4106UY4 Inherit from COG: Scp-like extracellular KHRBS_13610 ENOG41080XQ Signal transduction protein with cbs domains KHRBS_13625 ENOG41064X9 cytochrome C oxidase subunit IV KHRBS_13630 ENOG4105CCU oxidase (Subunit III) KHRBS_13635 ENOG4105BZ9 Cytochrome C oxidase, subunit I KHRBS_13645 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KHRBS_13655 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) KHRBS_13665 ENOG4105ZPI UPF0358 protein KHRBS_13670 ENOG4105CSV Glutaminase KHRBS_13680 ENOG4108IAB Phoh family KHRBS_13695 ENOG4105QA2 KHRBS_13700 ENOG4105CI3 gtp-binding protein typa KHRBS_13740 ENOG4105JQZ Methyltransferase KHRBS_13750 ENOG4105ECY inositol monophosphatase KHRBS_13765 ENOG4105WBI UPF0223 protein KHRBS_13770 ENOG4105CXN decarboxylase KHRBS_13780 ENOG4107QN2 dihydrolipoyl dehydrogenase KHRBS_13785 ENOG4105C7S Dehydrogenase KHRBS_13790 ENOG4105CPP Dehydrogenase, E1 component KHRBS_13810 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KHRBS_13815 ENOG4108X4Q Hydrolase KHRBS_13825 ENOG4105CN5 Metallo-Beta-Lactamase KHRBS_13835 ENOG4107ZYR domain protein KHRBS_13845 ENOG4105BZU Histidine kinase KHRBS_13870 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) KHRBS_13875 ENOG4105C5H ABC transporter KHRBS_13885 ENOG4105C3F Signal peptidase i KHRBS_13890 ENOG4105DM4 PTS System KHRBS_13895 ENOG4105DE4 1-phosphofructokinase KHRBS_13900 ENOG4105E98 transcriptional regulator DeoR family KHRBS_13905 ENOG4107RBB ABC transporter, permease KHRBS_13910 ENOG4105C19 ABC transporter KHRBS_13915 ENOG4107X8C Efflux transporter RND family MFP subunit KHRBS_13925 ENOG4105BZ1 (ABC) transporter KHRBS_13930 ENOG4105BZ1 (ABC) transporter KHRBS_13935 ENOG41067WU Molybdopterin converting factor (Subunit 1) KHRBS_13940 ENOG4108ZAF Molybdopterin KHRBS_13945 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein KHRBS_13950 ENOG4105CVM Molybdenum cofactor synthesis domain protein KHRBS_13955 ENOG4105D06 uba thif-type nad fad binding protein KHRBS_13960 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) KHRBS_13980 ENOG4105D3R alkyl hydroperoxide reductase KHRBS_13985 ENOG4105D8X mechanosensitive ion channel KHRBS_14005 ENOG4105NQC Flavodoxin KHRBS_14035 ENOG4108XRC Protein of unknown function (DUF458) KHRBS_14040 ENOG4107IN1 Protein of unknown function (DUF1797) KHRBS_14050 ENOG4105EPM Diguanylate phosphodiesterase KHRBS_14075 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein KHRBS_14090 ENOG4107R88 Chemotaxis protein (CheV) KHRBS_14100 ENOG4105CHM Aminotransferase KHRBS_14120 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase KHRBS_14125 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer KHRBS_14130 ENOG4105F6S Spore photoproduct lyase KHRBS_14140 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) KHRBS_14145 ENOG4105KRI phosphocarrier protein (HPr KHRBS_14155 ENOG4105CID antiterminator KHRBS_14170 ENOG4105DC7 peptidase M24 KHRBS_14180 ENOG4105C59 p-type ATPase KHRBS_14195 ENOG4105F0V Cell wall hydrolase KHRBS_14230 ENOG4105FEA Spore maturation protein KHRBS_14235 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr KHRBS_14245 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) KHRBS_14250 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) KHRBS_14255 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase KHRBS_14260 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) KHRBS_14265 ENOG4108K88 Membrane KHRBS_14275 ENOG4105E14 MotA TolQ exbB proton channel KHRBS_14280 ENOG4105ER2 Ompa motb domain protein KHRBS_14285 ENOG41090MY MarR family Transcriptional regulator KHRBS_14290 ENOG4105BZU Histidine kinase KHRBS_14310 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) KHRBS_14315 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) KHRBS_14320 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) KHRBS_14325 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit KHRBS_14335 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KHRBS_14340 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) KHRBS_14345 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) KHRBS_14355 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KHRBS_14365 ENOG4108TGC Acyltransferase KHRBS_14385 ENOG4105D0M Protease HtpX homolog KHRBS_14395 ENOG410681C small acid-soluble spore protein KHRBS_14405 ENOG4108WZW RNA polymerase sigma KHRBS_14410 ENOG4107TS3 membrane protein, TerC KHRBS_14415 ENOG4107T5V SNARE associated Golgi KHRBS_14420 ENOG4105BZU Histidine kinase KHRBS_14425 ENOG4105FDF Could be involved in DNA repair (By similarity) KHRBS_14475 ENOG4105V75 Transcriptional regulator KHRBS_14480 ENOG4105CJW magnesium transporter KHRBS_14495 ENOG4106849 propeptide, pepSY amd peptidase M4 KHRBS_14505 ENOG41062D9 Histidine kinase KHRBS_14510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KHRBS_14515 ENOG4108X43 YKOF domain protein KHRBS_14520 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein KHRBS_14525 ENOG4108JJB ABC transporter KHRBS_14530 ENOG4108W7F transporter, permease KHRBS_14540 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KHRBS_14545 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) KHRBS_14550 ENOG4107Y2X deaminase KHRBS_14560 ENOG4108ZHJ Organic hydroperoxide resistance protein KHRBS_14565 ENOG4105K56 Transcriptional regulator KHRBS_14580 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KHRBS_14585 ENOG4105CIY formyltetrahydrofolate deformylase KHRBS_14590 ENOG41080TC multidrug resistance protein KHRBS_14600 ENOG4108428 Inherit from COG: -acetyltransferase KHRBS_14625 ENOG4108S4H thioesterase Superfamily protein KHRBS_14630 ENOG4107TUM Amidinotransferase KHRBS_14635 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) KHRBS_14640 ENOG4108JQ7 (ABC) transporter KHRBS_14645 ENOG4107SN7 NLP P60 protein KHRBS_14650 ENOG4105DTQ mandelate racemase muconate lactonizing KHRBS_14655 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A KHRBS_14665 ENOG4105C3U ABC transporter KHRBS_14690 ENOG4105C0H protease KHRBS_14700 ENOG4105CKK Glycosyl transferase, family 2 KHRBS_14705 ENOG4105EDW glycosyl transferase, family 39 KHRBS_14715 ENOG4107R7I amino acid KHRBS_14720 ENOG4107GRR phosphate transport regulator KHRBS_14725 ENOG4105CJ3 phosphate transporter KHRBS_14740 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KHRBS_14770 ENOG41068G1 KHRBS_14780 ENOG410906S phage-like element pbsx protein xkdt KHRBS_14785 ENOG41066EA baseplate J family protein KHRBS_14790 ENOG4105MFU Protein of unknown function (DUF2634) KHRBS_14800 ENOG4105X7F KHRBS_14805 ENOG4108WZM domain protein KHRBS_14810 ENOG4108FKH Transglycosylase SLT domain KHRBS_14810 ENOG4108FKH Transglycosylase SLT domain KHRBS_14820 ENOG4105MTC XkdN-like protein KHRBS_14825 ENOG4105FR7 XkdM protein, phage-like element PBSX KHRBS_14830 ENOG4105PQS phage protein KHRBS_14845 ENOG41060SN KHRBS_14870 ENOG4108MDF Phage Portal Protein KHRBS_14875 ENOG4105IG6 Phage terminase, large subunit KHRBS_14880 ENOG4108TFU terminase (Small subunit) KHRBS_14930 ENOG410635T phage-like element pbsx protein KHRBS_14935 ENOG4105WEF catalase KHRBS_14940 ENOG4105K7W phage-related replication protein KHRBS_14945 ENOG4105KWG Pfam:DUF1696 KHRBS_14950 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase KHRBS_14955 ENOG41068K0 YCII-related domain KHRBS_14970 ENOG4105JD4 ATPase yjob KHRBS_14980 ENOG4107TSN permease KHRBS_14985 ENOG4105CTX dehydratase KHRBS_14995 ENOG4107KJX Transcriptional regulator KHRBS_15000 ENOG4108I5G Major Facilitator superfamily KHRBS_15005 ENOG4105DMW Dehydrogenase reductase KHRBS_15010 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) KHRBS_15015 ENOG4105CPQ Dehydrogenase KHRBS_15020 ENOG4105DG4 malate L-lactate dehydrogenase KHRBS_15025 ENOG4105CT4 transporter KHRBS_15030 ENOG4105D2H Uronic isomerase KHRBS_15045 ENOG4105Q95 Cupin 2, conserved barrel domain protein KHRBS_15055 ENOG4108IXI (ABC) transporter KHRBS_15060 ENOG4105C4B ABC transporter, permease KHRBS_15065 ENOG4105EXQ uroporphyrinogen iii synthase hem4 KHRBS_15080 ENOG4106A3M Cytochrome p-450 KHRBS_15105 ENOG4108IEG Formate dehydrogenase Alpha subunit KHRBS_15135 ENOG4107CUJ Protein of unknown function (DUF2690) KHRBS_15140 ENOG4108ZJ4 polysaccharide deacetylase KHRBS_15150 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KHRBS_15165 ENOG4108Z66 YbaK ebsC protein KHRBS_15175 ENOG4105VMI -acetyltransferase KHRBS_15180 ENOG4105G7B Protein of unknown function (DUF2992) KHRBS_15185 ENOG4105DG6 mannose-6-phosphate isomerase KHRBS_15205 ENOG4108PSK reductase KHRBS_15225 ENOG4107KNS KHRBS_15245 ENOG41068SY KHRBS_15260 ENOG4105JHY Membrane KHRBS_15265 ENOG4105D9U N-acetyltransferase KHRBS_15270 ENOG4105C28 cystathionine KHRBS_15275 ENOG4105C28 cystathionine KHRBS_15310 ENOG4108ZMI UPF0477 protein KHRBS_15325 ENOG4105ENA helicase KHRBS_15380 ENOG4107A88 KHRBS_15385 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH KHRBS_15390 ENOG4105DWF phosphomethylpyrimidine kinase KHRBS_15395 ENOG4105D06 uba thif-type nad fad binding protein KHRBS_15400 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) KHRBS_15420 ENOG4105ETU transcriptional activator (TenA KHRBS_15435 ENOG4105EMS pseudouridine synthase KHRBS_15440 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KHRBS_15455 ENOG4105MIX Adenylate cyclase KHRBS_15460 ENOG4105E4C Lytic transglycosylase catalytic KHRBS_15465 ENOG4108Z18 K06886 hemoglobin KHRBS_15470 ENOG4105T58 Dithiol-disulfide isomerase KHRBS_15485 ENOG4105DPN Oligoendopeptidase f KHRBS_15495 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis KHRBS_15500 ENOG4108ZCF integral membrane protein KHRBS_15505 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) KHRBS_15520 ENOG4108JQ7 (ABC) transporter KHRBS_15530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KHRBS_15535 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KHRBS_15540 ENOG4108J59 Extracellular solute-binding protein, family 5 KHRBS_15545 ENOG4105C31 Tryptophanyl-tRNA synthetase KHRBS_15555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KHRBS_15570 ENOG4108JQ7 (ABC) transporter KHRBS_15575 ENOG4105C3U ABC transporter KHRBS_15585 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KHRBS_15590 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) KHRBS_15605 ENOG4107RMD Basic membrane lipoprotein KHRBS_15630 ENOG4105DBV ornithine carbamoyltransferase KHRBS_15645 ENOG4105C8Y Acetylornithine aminotransferase KHRBS_15660 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase KHRBS_15670 ENOG4105IQ5 FAD linked oxidase domain protein KHRBS_15680 ENOG4105VG1 fes assembly suf system protein KHRBS_15685 ENOG4108MXZ Esterase KHRBS_15690 ENOG4108KP7 hydrolase KHRBS_15700 ENOG41073B9 KHRBS_15710 ENOG4107AYK membrAne KHRBS_15715 ENOG4105EPR degv family KHRBS_15720 ENOG4105D4Y metalloprotease KHRBS_15725 ENOG410751J KHRBS_15735 ENOG4105K7K Transcriptional regulator KHRBS_15755 ENOG4105QNR S1 RNA binding domain protein KHRBS_15760 ENOG4108VPT UPF0234 protein KHRBS_15770 ENOG4105MA6 gCN5-related N-acetyltransferase KHRBS_15775 ENOG4108SZE gCN5-related N-acetyltransferase KHRBS_15780 ENOG4107RCC Major Facilitator Superfamily KHRBS_15785 ENOG4105DIA mandelate racemase muconate lactonizing KHRBS_15795 ENOG41061P3 phosphosulfolactate synthase KHRBS_15800 ENOG4108N5B 2-phosphosulfolactate phosphatase KHRBS_15805 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) KHRBS_15810 ENOG4107RIQ Sulfate adenylate transferase KHRBS_15815 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) KHRBS_15820 ENOG4107S9D Alpha beta hydrolase KHRBS_15825 ENOG4105MYW Pentapeptide repeat protein KHRBS_15830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KHRBS_15835 ENOG4108ZUB Lysine exporter protein (Lyse ygga) KHRBS_15840 ENOG4105SF0 DinB family KHRBS_15845 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KHRBS_15850 ENOG4105ETE Transcriptional regulator (LacI family KHRBS_15855 ENOG4106HBX Transcriptional Regulator AraC Family KHRBS_15860 ENOG4105UQX Mate efflux family protein KHRBS_15875 ENOG4105CAQ asparagine synthetase KHRBS_15885 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KHRBS_15895 ENOG4105ERH Fumarylacetoacetate hydrolase KHRBS_15960 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation KHRBS_15975 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding KHRBS_15980 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) KHRBS_15985 ENOG4106K7D Major facilitator family transporter KHRBS_15990 ENOG4108KK1 membrane protein AbrB duplication KHRBS_16005 ENOG4105TRI Hydrolase KHRBS_16025 ENOG4107SCK Monooxygenase KHRBS_16040 ENOG41060YP KHRBS_16045 ENOG4106CAD Protein of unknown function (DUF3311) KHRBS_16050 ENOG4105E1V na solute symporter KHRBS_16055 ENOG4105X3H Excalibur domain protein KHRBS_16060 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KHRBS_16065 ENOG4105XVF Competence transcription factor KHRBS_16085 ENOG4106YBV Methyl-accepting chemotaxis KHRBS_16090 ENOG4107ZYJ bioY protein KHRBS_16095 ENOG4107F3J Amp-dependent synthetase and ligase KHRBS_16105 ENOG4107TB6 phosphoglycerate mutase KHRBS_16110 ENOG4108HUF Transporter KHRBS_16120 ENOG4105KD7 acetyltransferase KHRBS_16125 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KHRBS_16130 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 KHRBS_16140 ENOG4105CEY Amp-dependent synthetase and ligase KHRBS_16150 ENOG4105DF9 Lipoate-protein, ligase KHRBS_16155 ENOG4108RQ5 Beta-lactamase domain-containing protein KHRBS_16165 ENOG4106AXD KHRBS_16180 ENOG4105DER m42 family KHRBS_16190 ENOG41090T1 Membrane KHRBS_16200 ENOG4105ECB domain protein KHRBS_16210 ENOG4105C1Q protoporphyrinogen oxidase KHRBS_16215 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) KHRBS_16220 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) KHRBS_16225 ENOG4105BZ4 penicillin-binding protein KHRBS_16230 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation KHRBS_16265 ENOG4105K59 histidine triad (HIT) protein KHRBS_16270 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) KHRBS_16275 ENOG4105NBU tryptophan transport protein KHRBS_16310 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) KHRBS_16320 ENOG4105EQI Metal Dependent Phosphohydrolase KHRBS_16325 ENOG4106D4I domain protein KHRBS_16330 ENOG4107VRP DNA repair exonuclease KHRBS_16335 ENOG4105RHA ABC transporter, permease KHRBS_16340 ENOG4108IUX (ABC) transporter KHRBS_16350 ENOG4105CGU Enoyl-CoA hydratase KHRBS_16360 ENOG4105NCW Trka-c domain protein KHRBS_16365 ENOG4107S91 Sodium hydrogen exchanger KHRBS_16370 ENOG4105D4P Coproporphyrinogen iii oxidase KHRBS_16380 ENOG4105F1N DNA alkylation repair KHRBS_16385 ENOG4105WZB UPF0342 protein KHRBS_16390 ENOG4106MP8 UPF0754 membrane protein KHRBS_16400 ENOG410839P KHRBS_16420 ENOG4105BZ1 (ABC) transporter KHRBS_16425 ENOG4105BZ1 (ABC) transporter KHRBS_16445 ENOG4105F0I Aminotransferase KHRBS_16450 ENOG4107VMI polysaccharide deacetylase KHRBS_16455 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) KHRBS_16460 ENOG4105D64 Mechanosensitive ion channel KHRBS_16470 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KHRBS_16475 ENOG4105WMR Protein CrcB homolog KHRBS_16485 ENOG4105C37 (CBS) domain KHRBS_16490 ENOG4105CHM Aminotransferase KHRBS_16500 ENOG4105C37 (CBS) domain KHRBS_16505 ENOG4105F6E Acyl-transferase KHRBS_16510 ENOG4108FN7 Aldo keto reductase KHRBS_16515 ENOG4108AEY RNA polymerase sigma factor KHRBS_16520 ENOG4105J37 KHRBS_16535 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KHRBS_16540 ENOG4105C8J )-transporter KHRBS_16550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KHRBS_16570 ENOG4105G6Z alkaline phosphatase KHRBS_16575 ENOG4105ED1 spovr family KHRBS_16610 ENOG4105WH1 Two component transcriptional regulator luxr family KHRBS_16630 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) KHRBS_16640 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator KHRBS_16645 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KHRBS_16650 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KHRBS_16655 ENOG4107YBY Hydrolase KHRBS_16660 ENOG41080XP Cbs domain KHRBS_16670 ENOG4108YBP pseudouridine synthase KHRBS_16725 ENOG4105VEQ Cold shock protein KHRBS_16730 ENOG4108TU7 Inherit from COG: (ABC) transporter KHRBS_16735 ENOG4105CJ1 ABC, transporter KHRBS_16740 ENOG4105CZV ABC transporter KHRBS_16745 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family KHRBS_16760 ENOG4105CS1 NAD(P)H quinone oxidoreductase KHRBS_16765 ENOG4105C0R drug resistance transporter emrb qaca subfamily KHRBS_16770 ENOG4105CW7 secretion protein, HlyD family KHRBS_16775 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes KHRBS_16785 ENOG4106AKX UPF0229 protein KHRBS_16790 ENOG4105CYN Serine protein kinase KHRBS_16810 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) KHRBS_16820 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) KHRBS_16835 ENOG4105VZ8 Transcriptional regulator KHRBS_16840 ENOG4107D63 KHRBS_16845 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) KHRBS_16855 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) KHRBS_16860 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component KHRBS_16865 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein KHRBS_16870 ENOG4105E2Y ABC, transporter KHRBS_16885 ENOG4105DNP FAD linked oxidase domain protein KHRBS_16890 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) KHRBS_16910 ENOG4108N23 SpoOM-related protein KHRBS_17025 ENOG4105G5W regulator Fur family KHRBS_17030 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KHRBS_17040 ENOG4107NBY Membrane KHRBS_17045 ENOG4105BZ1 (ABC) transporter KHRBS_17050 ENOG4105EVI UPF0374 protein KHRBS_17065 ENOG4105CAN Short-chain dehydrogenase reductase Sdr KHRBS_17070 ENOG4106BXE KHRBS_17075 ENOG4105CEN a g-specific adenine glycosylase KHRBS_17080 ENOG41067AE Membrane-bound metal-dependent hydrolase KHRBS_17085 ENOG4105EJV Membrane KHRBS_17090 ENOG4105CKK Glycosyl transferase, family 2 KHRBS_17095 ENOG4105D74 hydrolase KHRBS_17100 ENOG4106AKJ KHRBS_17120 ENOG4105F27 Major Facilitator KHRBS_17140 ENOG4105ECP epimerase KHRBS_17155 ENOG4107Y03 Nitroreductase KHRBS_17160 ENOG4105JAB phenazine biosynthesis protein, phzf family KHRBS_17165 ENOG4108IHU transport system permease protein KHRBS_17170 ENOG4105DQ5 transport system permease protein KHRBS_17175 ENOG4108MES Periplasmic binding protein KHRBS_17195 ENOG4108YYS metal-dependent hydrolase (By similarity) KHRBS_17200 ENOG4107Y80 Major Facilitator superfamily KHRBS_17205 ENOG4105YA8 Transcriptional regulator KHRBS_17210 ENOG4105H93 Acyltransferase family KHRBS_17215 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold KHRBS_17220 ENOG4105U3E Transcriptional regulator KHRBS_17225 ENOG4108KYE ABC-2 type transporter KHRBS_17230 ENOG41090VJ ABC-2 type transporter KHRBS_17235 ENOG4105CJ1 ABC, transporter KHRBS_17240 ENOG4105WH1 Two component transcriptional regulator luxr family KHRBS_17245 ENOG4105BZU Histidine kinase KHRBS_17250 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase KHRBS_17260 ENOG4105BZ1 (ABC) transporter KHRBS_17265 ENOG4105BZ1 (ABC) transporter KHRBS_17270 ENOG4105CI1 PTS System KHRBS_17275 ENOG4108Q3X Transcriptional regulator KHRBS_17280 ENOG4105F8D glycoside hydrolase family 4 KHRBS_17310 ENOG41069DP small acid-soluble spore protein KHRBS_17325 ENOG4107QKR Dehydrogenase KHRBS_17335 ENOG4107RUY (E1 component), alpha subunit KHRBS_17360 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KHRBS_17370 ENOG4105D7N magnesium and cobalt transport protein CorA KHRBS_17375 ENOG4106KE4 Dehydrogenase KHRBS_17395 ENOG4105D8X mechanosensitive ion channel KHRBS_17405 ENOG4105UPD Calcium Proton KHRBS_17415 ENOG4108ISG Major Facilitator KHRBS_17435 ENOG4105KJF protein tyrosine phosphatase KHRBS_17450 ENOG4107RKG DJ-1/PfpI family KHRBS_17455 ENOG4105CGH 5'-nucleotidase KHRBS_17460 ENOG4108RCM Nitroreductase KHRBS_17465 ENOG4107414 GntR family transcriptional regulator KHRBS_17470 ENOG4105CG3 alpha amylase, catalytic region KHRBS_17475 ENOG4105C5Y PTS System KHRBS_17480 ENOG4105E1K spore germination protein KHRBS_17485 ENOG4105GEU Spore germination protein KHRBS_17510 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) KHRBS_17530 ENOG4108RPX mosc domain containing protein KHRBS_17535 ENOG410855V Acylphosphatase KHRBS_17565 ENOG4108MRH transcriptional regulatory protein KHRBS_17575 ENOG4107QPK )-transporter KHRBS_17580 ENOG4108J20 pectate lyase KHRBS_17595 ENOG4108HUF Transporter KHRBS_17600 ENOG4105DQ5 transport system permease protein KHRBS_17605 ENOG4108U1V ABC transporter, permease KHRBS_17610 ENOG4105E0A ABC, transporter KHRBS_17635 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein KHRBS_17645 ENOG4105FDU atp-dependent rna helicase KHRBS_17650 ENOG4105C5H ABC transporter KHRBS_17665 ENOG4105DXB Major Facilitator superfamily KHRBS_17670 ENOG4107SWG transcriptional regulator MERR family KHRBS_17680 ENOG4105C5H ABC transporter KHRBS_17685 ENOG4105FKZ Methyl-accepting chemotaxis KHRBS_17690 ENOG4105C26 Dehydrogenase KHRBS_17705 ENOG4105EU0 Major facilitator Superfamily KHRBS_17710 ENOG41090R9 glycosyltransferase KHRBS_17715 ENOG4107R51 Glycosyl transferase, family 2 KHRBS_17730 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase KHRBS_17735 ENOG4105E0M Sulfatase KHRBS_17740 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KHRBS_17745 ENOG4108R1P KHRBS_17750 ENOG41061H0 Monooxygenase KHRBS_17755 ENOG41082F9 transcriptional regulator KHRBS_17760 ENOG4108PCN EamA-like transporter family KHRBS_17765 ENOG4106I4J membrane KHRBS_17785 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily KHRBS_17790 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) KHRBS_17795 ENOG4105H67 Protein of unknown function (DUF421) KHRBS_17800 ENOG4105F8D glycoside hydrolase family 4 KHRBS_17805 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component KHRBS_17815 ENOG4105E0S extracellular solute-binding protein family 1 KHRBS_17820 ENOG4105EKC KHRBS_17840 ENOG4105CX8 fg-gap repeat protein KHRBS_17855 ENOG4107TDE lipolytic protein G-D-S-L family KHRBS_17860 ENOG41075H3 AraC family transcriptional regulator KHRBS_17865 ENOG4105F5H Glycosyl Hydrolase Family 88 KHRBS_17870 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component KHRBS_17875 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component KHRBS_17880 ENOG410769Z extracellular solute-binding protein family 1 KHRBS_17885 ENOG4105EQD regulatoR KHRBS_17890 ENOG4105C2F Histidine kinase KHRBS_17905 ENOG4105M18 -acetyltransferase KHRBS_17910 ENOG4105WEF catalase KHRBS_17925 ENOG4107S9F NmrA family KHRBS_17930 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein KHRBS_17935 ENOG4105M4P Tetr family transcriptional regulator KHRBS_17945 ENOG4105CDY transcriptional regulatory protein KHRBS_17995 ENOG4105DZR Type I site-specific deoxyribonuclease KHRBS_18010 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KHRBS_18015 ENOG4105CBD Diacylglycerol kinase KHRBS_18025 ENOG4108IG5 Transcriptional regulator KHRBS_18030 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KHRBS_18040 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KHRBS_18045 ENOG4105CK7 Sodium proline symporter KHRBS_18050 ENOG4105KT7 mgtC SapB transporter KHRBS_18055 ENOG4105CRN Aminoglycoside phosphotransferase KHRBS_18065 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) KHRBS_18075 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) KHRBS_18085 ENOG4105CBC glutamate synthase KHRBS_18090 ENOG4105KGF protein, YerC YecD KHRBS_18095 ENOG4108R5T secreted protein KHRBS_18120 ENOG4105C12 Phosphoribosylglycinamide synthetase KHRBS_18125 ENOG4105DC1 bifunctional purine biosynthesis protein purh KHRBS_18130 ENOG4108V3E phosphoribosylglycinamide formyltransferase KHRBS_18135 ENOG4105CXB phosphoribosylaminoimidazole synthetase KHRBS_18145 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii KHRBS_18150 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I KHRBS_18155 ENOG4105VR9 phosphoribosylformylglycinamidine synthase KHRBS_18160 ENOG4105C8V SAICAR synthetase KHRBS_18165 ENOG4105C83 adenylosuccinate lyase KHRBS_18170 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit KHRBS_18175 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) KHRBS_18200 ENOG4105C7N Xanthine uracil vitamin C permease KHRBS_18230 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KHRBS_18245 ENOG4105C85 amino acid KHRBS_18250 ENOG4107STQ Multicopper oxidase KHRBS_18260 ENOG4107YUH hydrolase KHRBS_18290 ENOG4107QNK )-transporter KHRBS_18295 ENOG4108ZMR Ion transport 2 domain-containing protein KHRBS_18305 ENOG4108WV1 Pfam:DUF477 KHRBS_18310 ENOG4105DQX Zinc finger domain KHRBS_18315 ENOG41087YS Phage shock protein A KHRBS_18325 ENOG4105CT4 transporter KHRBS_18330 ENOG4105CPQ Dehydrogenase KHRBS_18335 ENOG4105PGZ NB-ARC domain KHRBS_18350 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) KHRBS_18355 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) KHRBS_18360 ENOG4108TYN CAAX amino terminal protease family protein KHRBS_18370 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KHRBS_18375 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KHRBS_18380 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) KHRBS_18385 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KHRBS_18390 ENOG4105C5H ABC transporter KHRBS_18395 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KHRBS_18400 ENOG410801F ribosomal-protein-alanine acetyltransferase KHRBS_18405 ENOG41072GX Peptidase M22 Glycoprotease KHRBS_18410 ENOG4105K8N protein family UPF0079, ATPase KHRBS_18415 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) KHRBS_18460 ENOG4105D3P Mannan endo-1,4-beta-mannosidase KHRBS_18465 ENOG4105DG6 mannose-6-phosphate isomerase KHRBS_18470 ENOG4105EVU fructokinase KHRBS_18475 ENOG4108TZY GntR Family Transcriptional Regulator KHRBS_18480 ENOG4105CS2 ec 3.2.1.21 KHRBS_18490 ENOG4105VCP PTS System KHRBS_18495 ENOG4105VZJ PTS System KHRBS_18500 ENOG4105F27 Major Facilitator KHRBS_18505 ENOG41090UD (LipO)protein KHRBS_18510 ENOG4107TVP HD domain protein KHRBS_18515 ENOG4108YM7 Gcn5-related n-acetyltransferase KHRBS_18525 ENOG4108ZMX Domain of unknown function (DU1801) KHRBS_18530 ENOG4105G6Z alkaline phosphatase KHRBS_18550 ENOG4105DRR Transcriptional regulator, GntR family KHRBS_18560 ENOG4105C2C drug resistance transporter, Bcr CflA KHRBS_18565 ENOG4105FS7 Transcriptional regulator KHRBS_18570 ENOG4108TVJ Nitroreductase KHRBS_18575 ENOG4105EYF MMPL domain protein KHRBS_18580 ENOG41062A4 Transcriptional regulator KHRBS_18590 ENOG4105C85 amino acid KHRBS_18600 ENOG4105WQG acetyltransferase KHRBS_18610 ENOG4105PF9 Transcriptional regulator KHRBS_18630 ENOG4108QY0 Membrane KHRBS_18655 ENOG4105XXY Thioredoxin KHRBS_18660 ENOG4108VGI doxx family KHRBS_18670 ENOG4108TVJ Nitroreductase KHRBS_18675 ENOG41076HS cation diffusion facilitator family transporter KHRBS_18680 ENOG4108Z5V transcriptional regulator, merr family KHRBS_18685 ENOG4108UQV Membrane KHRBS_18690 ENOG4108WC5 Alpha Beta Hydrolase Fold protein KHRBS_18700 ENOG4108VB1 regulatoR KHRBS_18705 ENOG4105ENE Histidine kinase KHRBS_18715 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) KHRBS_18725 ENOG4108SQ9 flavin reductase domain protein, FMN-binding KHRBS_18735 ENOG4107Y9U Membrane KHRBS_18740 ENOG4105Z7P Acetyltransferase (GNAT) family KHRBS_18750 ENOG4107R5R arsenical pump membrane protein KHRBS_18755 ENOG41082YX Transcriptional regulator, arsr family KHRBS_18760 ENOG4108JGH Tetr family transcriptional regulator KHRBS_18765 ENOG4105EQ0 Major Facilitator superfamily KHRBS_18770 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein KHRBS_18775 ENOG4105KVH Transcriptional regulator KHRBS_18785 ENOG4107Z6X Transcriptional regulator KHRBS_18790 ENOG4105MJ9 esterase KHRBS_18795 ENOG4108ZMQ domain protein KHRBS_18800 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KHRBS_18805 ENOG4105T38 integral membrane protein KHRBS_18815 ENOG4105KRI phosphocarrier protein (HPr KHRBS_18825 ENOG4105GIG KHRBS_18840 ENOG4105DXI Major Facilitator superfamily KHRBS_18845 ENOG4107U9B transcriptional regulator KHRBS_18850 ENOG41086D8 Transcriptional regulator KHRBS_18855 ENOG4108UZ3 Transporter KHRBS_18860 ENOG4108MCI Transcriptional regulator, ARAC family KHRBS_18870 ENOG4108VJ1 Transcriptional regulator (CarD family KHRBS_18875 ENOG4105VEQ Cold shock protein KHRBS_18880 ENOG4108V4B ThiJ pfpI KHRBS_18905 ENOG4105VZ8 Transcriptional regulator KHRBS_19005 ENOG41064BQ Phosphatase KHRBS_19015 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KHRBS_19020 ENOG4105WN5 stage II sporulation protein KHRBS_19025 ENOG4107SGM protein serine threonine phosphatase KHRBS_19030 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase KHRBS_19035 ENOG4105FUA antagonist KHRBS_19040 ENOG4107MMM Anti-sigma-factor antagonist KHRBS_19045 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) KHRBS_19065 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) KHRBS_19080 ENOG410905X membrane-flanked domain protein KHRBS_19085 ENOG4105C1J atp-dependent rna helicase KHRBS_19090 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) KHRBS_19095 ENOG4105CPF Cell wall formation (By similarity) KHRBS_19100 ENOG4105SZ6 Thioredoxin KHRBS_19120 ENOG4105FDT acyl-CoA dehydrogenase KHRBS_19135 ENOG4105CJ1 ABC, transporter KHRBS_19150 ENOG4107QJT sodium dicarboxylate symporter KHRBS_19155 ENOG4108MRH transcriptional regulatory protein KHRBS_19160 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism KHRBS_19180 ENOG41082W1 Cupin 2, conserved barrel domain protein KHRBS_19185 ENOG4105QVS general stress protein KHRBS_19190 ENOG4105EU9 KHRBS_19195 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) KHRBS_19205 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) KHRBS_19225 ENOG4105C0X amino acid KHRBS_19240 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) KHRBS_19255 ENOG4105C9U ATP-dependent DNA helicase RecQ KHRBS_19265 ENOG4105VCH membrane KHRBS_19275 ENOG410606W general stress protein KHRBS_19290 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KHRBS_19295 ENOG4105HMZ Methyltransferase KHRBS_19305 ENOG4105ETD TRANSCRIPTIONal KHRBS_19310 ENOG4107QM2 Aldo Keto reductase KHRBS_19315 ENOG4107RVG penicillin-binding protein KHRBS_19320 ENOG41061CK Antibiotic biosynthesis monooxygenase KHRBS_19330 ENOG4105XJB lipolytic protein G-D-S-L family KHRBS_19335 ENOG4107258 Transcriptional regulator KHRBS_19345 ENOG4105P4J Allophanate hydrolase, subunit 1 KHRBS_19350 ENOG4105CFM UPF0317 protein KHRBS_19355 ENOG4105C5A transporter KHRBS_19360 ENOG4105E7W lamb ycsf family protein KHRBS_19390 ENOG4108ZX0 Signal peptidase I KHRBS_19395 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KHRBS_19420 ENOG4108ZYE Transcriptional regulator KHRBS_19425 ENOG4108T5E Copper resistance protein KHRBS_19430 ENOG4105KTB nuclear export factor GLE1 KHRBS_19435 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KHRBS_19445 ENOG4105C26 Dehydrogenase KHRBS_19450 ENOG4108JPW Aminotransferase KHRBS_19460 ENOG4105YVS arsR family transcriptional regulator KHRBS_19465 ENOG41067V3 Antibiotic biosynthesis monooxygenase KHRBS_19470 ENOG4108DBC nitroreductase KHRBS_19475 ENOG4105R8C Transcriptional regulator KHRBS_19490 ENOG4108IPW abc transporter atp-binding protein KHRBS_19495 ENOG4105CM4 permease protein KHRBS_19500 ENOG4105DHS permease protein KHRBS_19505 ENOG4105CFH Aspartokinase KHRBS_19525 ENOG4105BZU Histidine kinase KHRBS_19535 ENOG4107WD8 ABC transporter, permease KHRBS_19555 ENOG4105E1K spore germination protein KHRBS_19570 ENOG4105DUX Transporter KHRBS_19580 ENOG41069ZX KHRBS_19585 ENOG41069ZX KHRBS_19590 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) KHRBS_19595 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase KHRBS_19600 ENOG4106P55 Transcriptional regulator KHRBS_19610 ENOG4105DRP amino acid AbC transporter KHRBS_19615 ENOG4105CDA abc transporter atp-binding protein KHRBS_19625 ENOG4105W8Z 4'-phosphopantetheinyl transferase KHRBS_19635 ENOG4105SX7 Transporter KHRBS_19665 ENOG4105CEY Amp-dependent synthetase and ligase KHRBS_19675 ENOG4105KVH Transcriptional regulator KHRBS_19680 ENOG4108VA3 3-hexulose-6-phosphate synthase KHRBS_19685 ENOG41080HJ 6-phospho 3-hexuloisomerase KHRBS_19690 ENOG4105C8Q Methyl-accepting chemotaxis KHRBS_19705 ENOG4105CS2 ec 3.2.1.21 KHRBS_19715 ENOG4105HHM rdd domain containing protein KHRBS_19730 ENOG4105E5Q amino acid AbC transporter KHRBS_19735 ENOG4105CKI cobalamin synthesis protein KHRBS_19745 ENOG4105S7A ErfK ybiS ycfS ynhG family protein KHRBS_19765 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) KHRBS_19770 ENOG4108IFG nitrite reductase, (NAD(P)H) KHRBS_19775 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit KHRBS_19780 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KHRBS_19790 ENOG4105U6C Alpha beta hydrolase fold protein KHRBS_19795 ENOG4108PJD permease KHRBS_19805 ENOG4107YHD transcriptional regulator KHRBS_19810 ENOG4105CK7 Sodium proline symporter KHRBS_19815 ENOG4105C26 Dehydrogenase KHRBS_19825 ENOG410756H nucleotidyltransferase KHRBS_19830 ENOG4105I82 acetyl xylan esterase KHRBS_19835 ENOG4105C5Q Transcriptional regulator KHRBS_19840 ENOG41089UC methyltransferase, type 11 KHRBS_19845 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) KHRBS_19850 ENOG4105I1F Resistance protein KHRBS_19855 ENOG4107RA1 nh(3)-dependent nad( ) synthetase KHRBS_19860 ENOG4105EIG urea carboxylase-associated protein 1 KHRBS_19895 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KHRBS_19930 ENOG4107SQ8 Glycine betaine KHRBS_19935 ENOG4108IJ7 Glycine betaine KHRBS_19940 ENOG4108A65 Transcriptional regulator KHRBS_19945 ENOG4107XZQ multidrug resistance protein KHRBS_19950 ENOG41079KZ Major Facilitator Superfamily KHRBS_19960 ENOG4108TTB tellurium resistance protein KHRBS_19965 ENOG4107TS3 membrane protein, TerC KHRBS_19970 ENOG4106FN3 tellurium resistance protein KHRBS_19975 ENOG4106FN3 tellurium resistance protein KHRBS_19980 ENOG4108N0M stress protein KHRBS_19985 ENOG4105DEN Luciferase family KHRBS_19995 ENOG4105DIK (ABC) transporter KHRBS_20000 ENOG4105DSE periplasmic solute binding protein KHRBS_20010 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KHRBS_20040 ENOG4107SET aldo keto reductase KHRBS_20045 ENOG4108SDH ABC, transporter KHRBS_20050 ENOG4108IUW ABC transporter KHRBS_20055 ENOG4107Y7X LytTR KHRBS_20065 ENOG41060AI SEC-C motif KHRBS_20075 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold KHRBS_20080 ENOG4107RB3 L-asparaginase KHRBS_20085 ENOG4105J7D transcriptional regulator KHRBS_20090 ENOG4105C0R drug resistance transporter emrb qaca subfamily KHRBS_20095 ENOG4107EPV Aminotransferase class V KHRBS_20100 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) KHRBS_20105 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KHRBS_20110 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KHRBS_20115 ENOG4105DGI Alkaline phosphatase KHRBS_20125 ENOG4105MUA Resistance protein KHRBS_20160 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KHRBS_20180 ENOG4105CTX dehydratase KHRBS_20190 ENOG4105EQX glucarate dehydratase KHRBS_20195 ENOG4105DJB Major Facilitator Superfamily KHRBS_20200 ENOG4105C26 Dehydrogenase KHRBS_20205 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase KHRBS_20220 ENOG4105CSV Glutaminase KHRBS_20235 ENOG4108J5H Homocysteine s-methyltransferase KHRBS_20260 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) KHRBS_20265 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane KHRBS_20275 ENOG4105C72 UPF0176 protein KHRBS_20295 ENOG4107ZTW SNARE associated Golgi KHRBS_20300 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase KHRBS_20305 ENOG4108WC5 Alpha Beta Hydrolase Fold protein KHRBS_20320 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR KHRBS_20325 ENOG4106AXJ AraC family transcriptional regulator KHRBS_20330 ENOG410631K Membrane KHRBS_20345 ENOG4105DCM major facilitator superfamily KHRBS_20350 ENOG410645S MarR family Transcriptional regulator KHRBS_20360 ENOG4105CXY transporter KHRBS_20365 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KHRBS_20370 ENOG4107QTZ amino acid KHRBS_20385 ENOG4108HWY Beta-lactamase KHRBS_20395 ENOG4106DDH Sporulation-specific SASP protein KHRBS_20405 ENOG4106K80 KHRBS_20415 ENOG4105G0J serine threonine protein kinase KHRBS_20455 ENOG4108WUZ (ABC) transporter KHRBS_20460 ENOG41066N6 Abortive infection protein KHRBS_20465 ENOG4107ZBH radical SAM domain protein KHRBS_20485 ENOG4105WAB arsR family transcriptional regulator KHRBS_20490 ENOG4105GPN Uncharacterized conserved protein (DUF2294) KHRBS_20525 ENOG4105D03 DNA-3-methyladenine glycosylase II KHRBS_20530 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) KHRBS_20535 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) KHRBS_20540 ENOG4107U5W ybbr family KHRBS_20545 ENOG4105C8B TIGR00159 family KHRBS_20555 ENOG4105EMN RNA polymerase sigma factor KHRBS_20585 ENOG4105EWC Purine nucleoside phosphorylase KHRBS_20595 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate KHRBS_20615 ENOG4105D17 glycoside hydrolase, family 3 domain protein KHRBS_20620 ENOG4105EHZ conserved protein UCP016719 KHRBS_20625 ENOG410874W AraC family transcriptional regulator KHRBS_20645 ENOG4108SA1 esterase KHRBS_20655 ENOG4105CHH sulfate transporter KHRBS_20740 ENOG4108NMV polysaccharide deacetylase KHRBS_20755 ENOG4105D1F ATP-binding protein KHRBS_20770 ENOG4108I0C methyltransferase KHRBS_20775 ENOG4108UJD 30S ribosomal protein S9 KHRBS_20780 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) KHRBS_20790 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) KHRBS_20800 ENOG4108JJB ABC transporter KHRBS_20805 ENOG4108ZT0 50S ribosomal protein l17 KHRBS_20815 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) KHRBS_20820 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits KHRBS_20830 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) KHRBS_20840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) KHRBS_20850 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) KHRBS_20855 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) KHRBS_20860 ENOG4105VPB 50S ribosomal protein L30 KHRBS_20865 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) KHRBS_20870 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) KHRBS_20875 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) KHRBS_20880 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) KHRBS_20890 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits KHRBS_20900 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) KHRBS_20905 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal KHRBS_20910 ENOG41082SA 50s ribosomal protein l29 KHRBS_20915 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) KHRBS_20920 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) KHRBS_20925 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) KHRBS_20930 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) KHRBS_20935 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity KHRBS_20940 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) KHRBS_20945 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) KHRBS_20950 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) KHRBS_20955 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) KHRBS_20965 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) KHRBS_20970 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) KHRBS_20980 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) KHRBS_20985 ENOG4105XPM ribosomal protein KHRBS_20990 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KHRBS_20995 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KHRBS_21000 ENOG4107Y49 methyltransferase KHRBS_21005 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) KHRBS_21010 ENOG4108VZM 50s ribosomal protein L10 KHRBS_21020 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) KHRBS_21025 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KHRBS_21045 ENOG4105M0M Tetracycline resistance protein KHRBS_21050 ENOG4105C2N RNA methyltransferase TrmH family group 3 KHRBS_21055 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) KHRBS_21060 ENOG4105C8N cysteinyl-tRNA synthetase KHRBS_21075 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) KHRBS_21080 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) KHRBS_21085 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) KHRBS_21090 ENOG4105CTP PilT protein domain protein KHRBS_21095 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) KHRBS_21100 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) KHRBS_21110 ENOG41066A3 ATP guanido phosphotransferase KHRBS_21115 ENOG4108Z0C Uvrb UvrC protein KHRBS_21200 ENOG4105CRK lysyL-tRNA synthetase KHRBS_21205 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) KHRBS_21215 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase KHRBS_21220 ENOG4105KRF dihydroneopterin aldolase KHRBS_21225 ENOG4105EEI dihydropteroate synthase KHRBS_21235 ENOG4105DDQ anthranilate synthase KHRBS_21240 ENOG4105CRQ synthase (Component I) KHRBS_21245 ENOG4105C6T cysteine synthase KHRBS_21250 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase KHRBS_21255 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) KHRBS_21265 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) KHRBS_21270 ENOG4108UGV hypoxanthine phosphoribosyltransferase KHRBS_21275 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) KHRBS_21305 ENOG41060GV RNA binding s1 domain protein KHRBS_21325 ENOG41082I2 s4 domain protein KHRBS_21340 ENOG4108M14 stage v sporulation protein t KHRBS_21345 ENOG4108JA2 transcriptioN-repair coupling factor KHRBS_21355 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) KHRBS_21360 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) KHRBS_21365 ENOG4105C5T Phosphoribosyl pyrophosphate synthase KHRBS_21370 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) KHRBS_21380 ENOG4105K4W Could be involved in septation (By similarity) KHRBS_21385 ENOG4105KME endoribonuclease L-psp KHRBS_21390 ENOG4105DFT pur operon repressor KHRBS_21395 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) KHRBS_21400 ENOG4105XEW small acid-soluble spore protein KHRBS_21405 ENOG4105W42 Veg protein KHRBS_21410 ENOG4105XFA sporulation peptidase YabG KHRBS_21415 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) KHRBS_21425 ENOG41069ER domain protein KHRBS_21435 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) KHRBS_21440 ENOG4105KRN Transcriptional regulator, abrb family KHRBS_21445 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) KHRBS_21450 ENOG4105VC4 domain protein KHRBS_21455 ENOG41060K3 Methyltransferase KHRBS_21460 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) KHRBS_21465 ENOG4105MA4 psp1 domain protein KHRBS_21470 ENOG4105FA2 dna polymerase iii KHRBS_21475 ENOG4105XVJ Protein of unknown function (DUF327) KHRBS_21480 ENOG4105X0R protein from nitrogen regulatory protein P-II KHRBS_21485 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) KHRBS_21490 ENOG4105CXN decarboxylase KHRBS_21550 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) KHRBS_21555 ENOG4105C6E dna polymerase iii KHRBS_21565 ENOG4108Z6B deaminase KHRBS_21575 ENOG4105VRS hydrolase family 18 KHRBS_21585 ENOG4105ZMH deoxynucleoside kinase KHRBS_21595 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) KHRBS_21605 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) KHRBS_21610 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) KHRBS_21620 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) KHRBS_21655 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KHRBS_21660 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KHRBS_21675 ENOG410848D S4 domain protein YaaA KHRBS_21680 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)