locus-tag	class	description
DL538_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DL538_00010	COG0592	DNA-directed DNA polymerase activity
DL538_00015	COG2501	S4 domain
DL538_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DL538_00030	COG0187	DNA topoisomerase II activity
DL538_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DL538_00070	COG0517	IMP dehydrogenase activity
DL538_00070	COG0516	GMP reductase activity
DL538_00075	COG1686	Belongs to the peptidase S11 family
DL538_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DL538_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DL538_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DL538_00105	COG1428	Deoxynucleoside kinase
DL538_00110	COG1428	Deoxynucleoside kinase
DL538_00115	COG1388	LysM domain
DL538_00115	COG3858	chitin binding
DL538_00120	COG1335	isochorismatase
DL538_00125	COG0590	tRNA wobble adenosine to inosine editing
DL538_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DL538_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DL538_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DL538_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DL538_00195	COG3853	Toxic anion resistance protein (TelA)
DL538_00200	COG1982	Orn Lys Arg decarboxylase major
DL538_00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DL538_00210	COG3870	Protein conserved in bacteria
DL538_00215	COG1728	Protein conserved in bacteria
DL538_00220	COG0470	DNA polymerase III
DL538_00225	COG1774	PSP1 C-terminal conserved region
DL538_00230	COG4467	Involved in initiation control of chromosome replication
DL538_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DL538_00240	COG2827	Endonuclease containing a URI domain
DL538_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DL538_00250	COG2002	toxin-antitoxin pair type II binding
DL538_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DL538_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DL538_00260	COG0084	hydrolase, TatD family'
DL538_00265	COG3584	3D domain protein
DL538_00265	COG3583	domain protein
DL538_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DL538_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DL538_00285	COG4466	Protein conserved in bacteria
DL538_00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DL538_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DL538_00305	COG0251	oxidation-reduction process
DL538_00310	COG2088	sporulation resulting in formation of a cellular spore
DL538_00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DL538_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DL538_00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DL538_00330	COG0193	aminoacyl-tRNA hydrolase activity
DL538_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DL538_00345	COG2002	toxin-antitoxin pair type II binding
DL538_00350	COG2244	polysaccharide biosynthetic process
DL538_00355	COG3956	TIGRFAM MazG family protein
DL538_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DL538_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DL538_00380	COG1098	S1 RNA binding domain
DL538_00395	COG2208	phosphoserine phosphatase activity
DL538_00400	COG2304	oxidoreductase activity
DL538_00405	COG0515	serine threonine protein kinase
DL538_00410	COG0037	tRNA processing
DL538_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DL538_00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DL538_00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DL538_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DL538_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DL538_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DL538_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
DL538_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DL538_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DL538_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DL538_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DL538_00475	COG1396	sequence-specific DNA binding
DL538_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DL538_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DL538_00565	COG4463	regulation of RNA biosynthetic process
DL538_00570	COG3880	PFAM UvrB UvrC protein
DL538_00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DL538_00580	COG0542	response to heat
DL538_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DL538_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DL538_00595	COG4956	integral membrane protein (PIN domain superfamily)
DL538_00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DL538_00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DL538_00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DL538_00620	COG1045	serine acetyltransferase
DL538_00625	COG0215	cysteine-tRNA ligase activity
DL538_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DL538_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DL538_00640	COG3688	RNA-binding protein containing a PIN domain
DL538_00645	COG1595	DNA-templated transcription, initiation
DL538_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DL538_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DL538_00660	COG0250	Participates in transcription elongation, termination and antitermination
DL538_00665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DL538_00670	COG0081	regulation of translation
DL538_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DL538_00680	COG0222	ribosome binding
DL538_00685	COG2813	Specifically methylates the guanine in position
DL538_00690	COG0085	RNA polymerase activity
DL538_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DL538_00700	COG1358	cellular component organization or biogenesis
DL538_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DL538_00710	COG0049	tRNA binding
DL538_00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DL538_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DL538_00725	COG0596	Alpha beta hydrolase
DL538_00730	COG0051	transcription antitermination factor activity, RNA binding
DL538_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DL538_00740	COG0088	Forms part of the polypeptide exit tunnel
DL538_00745	COG0089	rRNA binding
DL538_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DL538_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DL538_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DL538_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DL538_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DL538_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
DL538_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DL538_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DL538_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DL538_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DL538_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DL538_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DL538_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DL538_00825	COG1841	ribosomal large subunit assembly
DL538_00830	COG0200	Binds to the 23S rRNA
DL538_00835	COG0201	protein transport
DL538_00840	COG0563	adenylate kinase activity
DL538_00845	COG0024	Methionine aminopeptidase
DL538_00850	COG2163	COG2163 Ribosomal protein L14E L6E L27E
DL538_00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DL538_00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DL538_00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DL538_00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DL538_00875	COG0202	RNA polymerase activity
DL538_00880	COG0203	ribosomal protein L17
DL538_00885	COG1122	ATPase activity
DL538_00890	COG1122	ATPase activity
DL538_00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DL538_00900	COG0101	tRNA pseudouridine synthase activity
DL538_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DL538_00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DL538_00915	COG2226	methyltransferase
DL538_00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
DL538_00930	COG0489	protein tyrosine kinase activity
DL538_00940	COG2194	sulfuric ester hydrolase activity
DL538_00945	COG0726	polysaccharide deacetylase
DL538_00980	COG2856	Zn peptidase
DL538_00990	COG1395	domain, Protein
DL538_01050	COG0305	Participates in initiation and elongation during chromosome replication
DL538_01155	COG1783	phage Terminase large subunit
DL538_01160	COG5518	Phage portal protein
DL538_01165	COG2369	cell adhesion
DL538_01175	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DL538_01180	COG4653	Phage capsid family
DL538_01240	COG3953	SLT domain
DL538_01240	COG5280	Phage tail tape measure protein TP901
DL538_01245	COG1652	LysM domain
DL538_01255	COG4193	domain, Protein
DL538_01265	COG3628	GPW Gp25 family protein
DL538_01270	COG3299	homolog of phage Mu protein gp47
DL538_01275	COG3778	Protein conserved in bacteria
DL538_01315	COG3409	Peptidoglycan-binding domain 1 protein
DL538_01315	COG1388	LysM domain
DL538_01315	COG5632	N-Acetylmuramoyl-L-alanine amidase
DL538_01325	COG5444	nuclease activity
DL538_01330	COG0457	Tetratricopeptide repeat
DL538_01345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DL538_01410	COG0659	secondary active sulfate transmembrane transporter activity
DL538_01415	COG0385	Bile acid
DL538_01420	COG2819	hydrolase of the alpha beta superfamily
DL538_01425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_01430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_01435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DL538_01440	COG2207	Transcriptional regulator
DL538_01440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DL538_01445	COG3876	Protein conserved in bacteria
DL538_01450	COG1472	Belongs to the glycosyl hydrolase 3 family
DL538_01455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DL538_01460	COG1263	PTS System
DL538_01460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_01465	COG1737	Transcriptional regulator
DL538_01470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DL538_01475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DL538_01480	COG1683	Conserved Protein
DL538_01510	COG1595	DNA-templated transcription, initiation
DL538_01515	COG5662	AntiSigma factor
DL538_01520	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DL538_01525	COG4856	YbbR-like protein
DL538_01530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DL538_01535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DL538_01545	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DL538_01550	COG2169	Transcriptional regulator
DL538_01555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DL538_01560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DL538_01565	COG3002	Belongs to the UPF0753 family
DL538_01570	COG0288	reversible hydration of carbon dioxide
DL538_01580	COG5609	conserved protein (DUF2294)
DL538_01585	COG0640	Transcriptional regulator
DL538_01590	COG2814	Major facilitator Superfamily
DL538_01605	COG0535	radical SAM domain protein
DL538_01610	COG1266	CAAX protease self-immunity
DL538_01615	COG1131	(ABC) transporter
DL538_01625	COG1413	lyase activity
DL538_01630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_01635	COG0596	Alpha beta hydrolase
DL538_01640	COG0745	RESPONSE REGULATOR receiver
DL538_01645	COG0642	Histidine kinase
DL538_01655	COG0515	serine threonine protein kinase
DL538_01670	COG1113	amino acid transport
DL538_01690	COG2124	cytochrome p450
DL538_01700	COG0531	amino acid
DL538_01705	COG0584	glycerophosphoryl diester phosphodiesterase
DL538_01710	COG2271	Major facilitator Superfamily
DL538_01725	COG1846	Transcriptional regulator
DL538_01725	COG0456	acetyltransferase
DL538_01730	COG2271	Major facilitator Superfamily
DL538_01740	COG3409	Peptidoglycan-binding domain 1 protein
DL538_01745	COG0697	spore germination
DL538_01750	COG2207	Transcriptional regulator
DL538_01750	COG1917	Cupin 2, conserved barrel domain protein
DL538_01755	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DL538_01760	COG3591	Belongs to the peptidase S1B family
DL538_01770	COG0596	Alpha beta hydrolase
DL538_01775	COG1183	phosphatidylcholine synthase activity
DL538_01780	COG0586	Pfam SNARE associated Golgi protein
DL538_01785	COG0688	phosphatidylethanolamine metabolic process
DL538_01795	COG2312	Erythromycin esterase
DL538_01800	COG2207	Transcriptional regulator
DL538_01810	COG1301	dicarboxylic acid transport
DL538_01815	COG1263	PTS System
DL538_01815	COG2190	(PTS) system
DL538_01815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_01820	COG0363	glucosamine-6-phosphate deaminase activity
DL538_01835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DL538_01840	COG0833	amino acid
DL538_01845	COG2040	homocysteine
DL538_01855	COG1115	amino acid carrier protein
DL538_01860	COG2066	Belongs to the glutaminase family
DL538_01865	COG4191	Histidine kinase
DL538_01870	COG0784	Response regulator, receiver
DL538_01880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DL538_01885	COG1012	belongs to the aldehyde dehydrogenase family
DL538_01890	COG2271	Major facilitator Superfamily
DL538_01895	COG4948	Mandelate Racemase Muconate Lactonizing
DL538_01900	COG2186	Transcriptional regulator
DL538_01905	COG2721	sulfolactate sulfo-lyase activity
DL538_01910	COG3173	Aminoglycoside phosphotransferase
DL538_01920	COG0697	spore germination
DL538_01925	COG0745	RESPONSE REGULATOR receiver
DL538_01930	COG2205	protein histidine kinase activity
DL538_01935	COG1131	(ABC) transporter
DL538_01950	COG3773	Cell wall hydrolase
DL538_01955	COG2304	oxidoreductase activity
DL538_01965	COG3540	Alkaline phosphatase
DL538_01970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DL538_01975	COG0805	protein transport
DL538_01980	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DL538_01985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DL538_01990	COG0477	Major facilitator Superfamily
DL538_01995	COG1309	transcriptional regulator
DL538_02000	COG0252	asparaginase activity
DL538_02005	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DL538_02010	COG1714	RDD family
DL538_02015	COG1405	negative regulation of cell septum assembly
DL538_02015	COG3012	SEC-C Motif Domain Protein
DL538_02020	COG3290	protein histidine kinase activity
DL538_02025	COG3279	Response regulator of the LytR AlgR family
DL538_02030	COG4555	ABC transporter
DL538_02035	COG1668	transmembrane transport
DL538_02040	COG0667	Aldo Keto reductase
DL538_02050	COG1595	DNA-templated transcription, initiation
DL538_02060	COG1595	DNA-templated transcription, initiation
DL538_02065	COG1876	peptidase activity
DL538_02070	COG0457	Tetratricopeptide repeat
DL538_02075	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_02080	COG0366	Alpha amylase catalytic
DL538_02085	COG0803	Belongs to the bacterial solute-binding protein 9 family
DL538_02090	COG1121	(ABC) transporter
DL538_02095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DL538_02100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DL538_02105	COG2310	stress, protein
DL538_02110	COG2310	stress, protein
DL538_02115	COG2310	stress, protein
DL538_02120	COG0861	Integral membrane protein TerC family
DL538_02130	COG3853	Toxic anion resistance protein (TelA)
DL538_02135	COG0477	Major facilitator Superfamily
DL538_02145	COG2814	Major facilitator Superfamily
DL538_02150	COG0640	Transcriptional regulator
DL538_02155	COG4175	Glycine betaine
DL538_02155	COG0517	IMP dehydrogenase activity
DL538_02160	COG4176	ABC-type proline glycine betaine transport system permease component
DL538_02165	COG2113	Glycine betaine
DL538_02170	COG1473	amidohydrolase
DL538_02175	COG1288	antiporter activity
DL538_02185	COG0366	Alpha amylase catalytic
DL538_02190	COG0039	L-malate dehydrogenase activity
DL538_02195	COG1620	l-lactate permease
DL538_02200	COG2814	Major facilitator Superfamily
DL538_02205	COG1846	Transcriptional regulator
DL538_02210	COG1280	lysine exporter protein (LysE YggA)
DL538_02215	COG3403	YqcI/YcgG family
DL538_02220	COG1113	amino acid transport
DL538_02225	COG3665	Urea carboxylase-associated protein
DL538_02230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DL538_02235	COG1660	Displays ATPase and GTPase activities
DL538_02240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DL538_02245	COG2226	methyltransferase
DL538_02250	COG0583	DNA-binding transcription factor activity
DL538_02255	COG3458	cephalosporin-C deacetylase activity
DL538_02260	COG3541	Predicted nucleotidyltransferase
DL538_02265	COG0506	proline dehydrogenase activity
DL538_02270	COG1012	belongs to the aldehyde dehydrogenase family
DL538_02275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DL538_02280	COG2508	Transcriptional regulator
DL538_02285	COG3689	TIGRFAM TIGR03943 family protein
DL538_02290	COG0701	Predicted permease
DL538_02295	COG2267	carboxylic ester hydrolase activity
DL538_02300	COG0492	ferredoxin-NADP+ reductase activity
DL538_02305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DL538_02305	COG1587	Uroporphyrinogen-III synthase
DL538_02310	COG2146	nitrite reductase [NAD(P)H] activity
DL538_02315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DL538_02320	COG0243	molybdopterin cofactor binding
DL538_02325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DL538_02330	COG2223	nitrite transmembrane transporter activity
DL538_02340	COG1376	ErfK ybiS ycfS ynhG family protein
DL538_02350	COG0523	cobalamin synthesis protein
DL538_02355	COG0765	amino acid transport
DL538_02360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DL538_02375	COG1846	Transcriptional regulator
DL538_02390	COG2723	6-phospho-beta-galactosidase activity
DL538_02400	COG3209	COG3209 Rhs family protein
DL538_02405	COG3290	protein histidine kinase activity
DL538_02405	COG0840	transmembrane signaling receptor activity
DL538_02410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DL538_02415	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DL538_02420	COG1733	regulation of RNA biosynthetic process
DL538_02425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_02430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_02435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_02440	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DL538_02445	COG2814	Major facilitator Superfamily
DL538_02455	COG0697	spore germination
DL538_02460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DL538_02470	COG2364	Membrane
DL538_02475	COG1126	abc transporter atp-binding protein
DL538_02480	COG0765	amino acid transport
DL538_02485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DL538_02490	COG0583	DNA-binding transcription factor activity
DL538_02495	COG0163	prenyltransferase activity
DL538_02500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DL538_02515	COG0596	Alpha beta hydrolase
DL538_02520	COG3104	oligopeptide transport
DL538_02525	COG5434	Belongs to the glycosyl hydrolase 28 family
DL538_02535	COG0697	spore germination
DL538_02545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DL538_02550	COG1136	(ABC) transporter
DL538_02555	COG0577	efflux transmembrane transporter activity
DL538_02560	COG0745	RESPONSE REGULATOR receiver
DL538_02565	COG5002	protein histidine kinase activity
DL538_02565	COG3850	Histidine kinase
DL538_02570	COG0457	Tetratricopeptide repeat
DL538_02590	COG0527	aspartate kinase activity
DL538_02595	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_02600	COG4605	iron ion homeostasis
DL538_02605	COG4604	ABC transporter, ATP-binding protein
DL538_02610	COG4607	ABC-type enterochelin transport system periplasmic component
DL538_02615	COG2814	Major facilitator Superfamily
DL538_02620	COG1309	transcriptional regulator
DL538_02625	COG0778	Nitroreductase
DL538_02630	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DL538_02635	COG0640	Transcriptional regulator
DL538_02640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DL538_02645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DL538_02650	COG1012	belongs to the aldehyde dehydrogenase family
DL538_02655	COG4975	Glucose uptake
DL538_02660	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_02665	COG4549	nuclear export factor GLE1
DL538_02670	COG1276	copper resistance
DL538_02670	COG2372	response to copper ion
DL538_02675	COG1349	DNA-binding transcription factor activity
DL538_02685	COG2213	PTS system mannitol-specific
DL538_02690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DL538_02695	COG0246	Mannitol dehydrogenase
DL538_02700	COG0473	3-isopropylmalate dehydrogenase activity
DL538_02705	COG0681	Belongs to the peptidase S26 family
DL538_02710	COG0412	Dienelactone hydrolase
DL538_02715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DL538_02725	COG0561	phosphatase activity
DL538_02730	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DL538_02735	COG1914	H( )-stimulated, divalent metal cation uptake system
DL538_02740	COG4336	lyase activity
DL538_02745	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DL538_02750	COG1984	allophanate hydrolase subunit 2
DL538_02755	COG1414	Transcriptional regulator
DL538_02760	COG2755	lipolytic protein G-D-S-L family
DL538_02770	COG2329	Antibiotic biosynthesis monooxygenase
DL538_02775	COG0768	penicillin binding
DL538_02780	COG4989	oxidoreductase activity
DL538_02785	COG3711	transcriptional antiterminator
DL538_02790	COG0318	PFAM AMP-dependent synthetase and ligase
DL538_02795	COG2226	methyltransferase
DL538_02800	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_02805	COG1917	Cupin 2, conserved barrel domain protein
DL538_02810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DL538_02815	COG3871	stress protein (general stress protein 26)
DL538_02825	COG2814	Major facilitator Superfamily
DL538_02830	COG1522	sequence-specific DNA binding
DL538_02835	COG0551	DNA topoisomerase type I activity
DL538_02835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DL538_02840	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DL538_02845	COG3706	GGDEF domain
DL538_02850	COG5298	Protein conserved in bacteria
DL538_02855	COG1215	transferase activity, transferring glycosyl groups
DL538_02865	COG0531	amino acid
DL538_02870	COG0494	nUDIX hydrolase
DL538_02875	COG0028	Belongs to the TPP enzyme family
DL538_02885	COG1914	H( )-stimulated, divalent metal cation uptake system
DL538_02890	COG2261	transglycosylase associated protein
DL538_02895	COG4876	unkown
DL538_02900	COG2217	Heavy metal translocating P-type atpase
DL538_02905	COG3729	General stress protein
DL538_02915	COG2329	Antibiotic biosynthesis monooxygenase
DL538_02920	COG3546	catalase activity
DL538_02925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DL538_02930	COG3290	protein histidine kinase activity
DL538_02935	COG4565	transcriptional regulatory protein
DL538_02940	COG1301	dicarboxylic acid transport
DL538_02945	COG0628	permease
DL538_02950	COG1131	(ABC) transporter
DL538_02955	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DL538_02965	COG1960	acyl-CoA dehydrogenase activity
DL538_02980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DL538_02985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_02990	COG1181	Belongs to the D-alanine--D-alanine ligase family
DL538_02995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DL538_03005	COG0513	Belongs to the DEAD box helicase family
DL538_03010	COG3402	PFAM membrane-flanked domain
DL538_03015	COG3428	Bacterial PH domain
DL538_03020	COG0705	Rhomboid family
DL538_03025	COG0736	holo-[acyl-carrier-protein] synthase activity
DL538_03030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DL538_03035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DL538_03040	COG0864	Transcriptional regulator
DL538_03045	COG2337	Toxic component of a toxin-antitoxin (TA) module
DL538_03050	COG1366	Belongs to the anti-sigma-factor antagonist family
DL538_03055	COG1366	Belongs to the anti-sigma-factor antagonist family
DL538_03060	COG2172	sigma factor antagonist activity
DL538_03065	COG2208	phosphoserine phosphatase activity
DL538_03070	COG1366	Belongs to the anti-sigma-factor antagonist family
DL538_03075	COG2172	sigma factor antagonist activity
DL538_03080	COG1191	sigma factor activity
DL538_03085	COG2208	phosphoserine phosphatase activity
DL538_03090	COG2183	response to ionizing radiation
DL538_03100	COG3091	SprT-like family
DL538_03165	COG1476	TRANSCRIPTIONal
DL538_03190	COG0693	protein deglycase activity
DL538_03195	COG1278	Cold shock
DL538_03200	COG1329	Transcriptional regulator
DL538_03210	COG0697	spore germination
DL538_03215	COG1917	Cupin 2, conserved barrel domain protein
DL538_03215	COG2207	Transcriptional regulator
DL538_03220	COG0697	spore germination
DL538_03225	COG2207	Transcriptional regulator
DL538_03225	COG3708	Transcriptional regulator
DL538_03230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DL538_03235	COG0477	Major facilitator Superfamily
DL538_03265	COG1309	transcriptional regulator
DL538_03270	COG0697	spore germination
DL538_03275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DL538_03280	COG2030	dehydratase
DL538_03285	COG3545	Serine hydrolase
DL538_03290	COG1733	regulation of RNA biosynthetic process
DL538_03295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DL538_03300	COG1733	regulation of RNA biosynthetic process
DL538_03305	COG2249	NAD(P)H dehydrogenase (quinone) activity
DL538_03310	COG2814	Major facilitator Superfamily
DL538_03315	COG1309	transcriptional regulator
DL538_03320	COG0640	Transcriptional regulator
DL538_03325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DL538_03335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DL538_03340	COG0697	spore germination
DL538_03345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DL538_03350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DL538_03355	COG0640	Transcriptional regulator
DL538_03360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DL538_03375	COG4585	Histidine kinase
DL538_03380	COG2197	response regulator
DL538_03385	COG2409	Drug exporters of the RND superfamily
DL538_03390	COG0596	Alpha beta hydrolase
DL538_03395	COG1811	Na channel or pump
DL538_03400	COG0789	Transcriptional regulator
DL538_03400	COG4978	Transcriptional regulator
DL538_03405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DL538_03410	COG0778	Nitroreductase
DL538_03415	COG0346	lactoylglutathione lyase activity
DL538_03420	COG2259	Doxx family
DL538_03425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_03440	COG2323	membrane
DL538_03445	COG2323	membrane
DL538_03450	COG0071	Belongs to the small heat shock protein (HSP20) family
DL538_03465	COG1309	transcriptional regulator
DL538_03475	COG0456	acetyltransferase
DL538_03485	COG1113	amino acid transport
DL538_03490	COG2318	DinB family
DL538_03495	COG1846	Transcriptional regulator
DL538_03500	COG1033	growth of symbiont in host cell
DL538_03500	COG2409	Drug exporters of the RND superfamily
DL538_03505	COG0778	Nitroreductase
DL538_03510	COG1846	Transcriptional regulator
DL538_03515	COG2814	Major facilitator Superfamily
DL538_03520	COG0730	response to heat
DL538_03525	COG1802	Transcriptional regulator
DL538_03530	COG1388	LysM domain
DL538_03530	COG3858	chitin binding
DL538_03535	COG1819	glycosyl
DL538_03545	COG1785	Belongs to the alkaline phosphatase family
DL538_03550	COG5646	InterPro IPR014922
DL538_03560	COG0454	-acetyltransferase
DL538_03565	COG1078	dGTPase activity
DL538_03570	COG1388	LysM domain
DL538_03575	COG2814	Major facilitator Superfamily
DL538_03580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DL538_03585	COG1447	Phosphotransferase system cellobiose-specific component IIA
DL538_03590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DL538_03595	COG2723	6-phospho-beta-galactosidase activity
DL538_03600	COG2188	Transcriptional regulator
DL538_03605	COG1940	carbohydrate kinase activity
DL538_03610	COG1482	cell wall glycoprotein biosynthetic process
DL538_03615	COG4124	Belongs to the glycosyl hydrolase 26 family
DL538_03660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DL538_03665	COG0802	atpase or kinase
DL538_03670	COG1214	PFAM Peptidase M22, glycoprotease
DL538_03675	COG0456	acetyltransferase
DL538_03680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DL538_03685	COG0488	(ABC) transporter
DL538_03690	COG0315	cyclic pyranopterin monophosphate synthase activity
DL538_03695	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DL538_03700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DL538_03705	COG0805	protein transport
DL538_03720	COG1266	CAAX protease self-immunity
DL538_03725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DL538_03730	COG0459	protein refolding
DL538_03740	COG1073	alpha beta
DL538_03745	COG0457	Tetratricopeptide repeat
DL538_03750	COG1063	alcohol dehydrogenase
DL538_03755	COG2211	Major facilitator Superfamily
DL538_03760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DL538_03765	COG1842	Phage shock protein A
DL538_03770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DL538_03775	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DL538_03780	COG4260	virion core protein, lumpy skin disease virus
DL538_03790	COG2814	Major facilitator Superfamily
DL538_03795	COG1063	alcohol dehydrogenase
DL538_03800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DL538_03805	COG0823	Involved in the tonB-independent uptake of proteins
DL538_03820	COG2267	carboxylic ester hydrolase activity
DL538_03830	COG2132	Multicopper oxidase
DL538_03835	COG1113	amino acid transport
DL538_03845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DL538_03850	COG0714	Associated with various cellular activities
DL538_03855	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DL538_03860	COG1305	Transglutaminase-like
DL538_03865	COG0519	Catalyzes the synthesis of GMP from XMP
DL538_03865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DL538_03885	COG2252	PERMEase
DL538_03890	COG3064	Membrane
DL538_03900	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DL538_03910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DL538_03915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DL538_03920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DL538_03925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DL538_03930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DL538_03935	COG0047	phosphoribosylformylglycinamidine synthase activity
DL538_03940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DL538_03945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DL538_03950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DL538_03955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DL538_03960	COG0138	bifunctional purine biosynthesis protein purh
DL538_03965	COG0151	Belongs to the GarS family
DL538_03970	COG1522	sequence-specific DNA binding
DL538_03975	COG0531	amino acid
DL538_03985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DL538_03990	COG1470	cell adhesion involved in biofilm formation
DL538_03995	COG4496	protein, YerC YecD
DL538_04000	COG0069	glutamate synthase activity
DL538_04005	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DL538_04010	COG0210	DNA helicase
DL538_04015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DL538_04020	COG4851	CamS sex pheromone cAM373 precursor
DL538_04025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DL538_04030	COG1285	pathogenesis
DL538_04035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DL538_04040	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DL538_04045	COG0154	amidase activity
DL538_04050	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DL538_04055	COG1309	transcriptional regulator
DL538_04060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DL538_04065	COG1597	lipid kinase activity
DL538_04070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DL538_04080	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DL538_04085	COG0732	type I restriction modification DNA specificity domain
DL538_04095	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DL538_04125	COG5444	nuclease activity
DL538_04135	COG3586	endonuclease activity
DL538_04145	COG2323	membrane
DL538_04150	COG0457	Tetratricopeptide repeat
DL538_04160	COG0217	transcriptional regulatory protein
DL538_04170	COG1309	transcriptional regulator
DL538_04175	COG3631	Ketosteroid isomerase-related protein
DL538_04180	COG0702	epimerase
DL538_04195	COG3546	catalase activity
DL538_04200	COG0454	-acetyltransferase
DL538_04210	COG5578	integral membrane protein
DL538_04215	COG2972	Histidine kinase
DL538_04220	COG2207	Transcriptional regulator
DL538_04220	COG4753	response regulator
DL538_04225	COG1653	transport
DL538_04230	COG1175	transmembrane transport
DL538_04235	COG0395	ABC-type sugar transport system, permease component
DL538_04240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DL538_04245	COG2207	Transcriptional regulator
DL538_04250	COG2755	lipolytic protein G-D-S-L family
DL538_04260	COG5578	integral membrane protein
DL538_04265	COG3401	FG-GAP repeat protein
DL538_04270	COG3401	FG-GAP repeat protein
DL538_04275	COG2755	lipolytic protein G-D-S-L family
DL538_04280	COG1874	Beta-galactosidase
DL538_04290	COG1653	transport
DL538_04295	COG4209	transmembrane transport
DL538_04300	COG0395	ABC-type sugar transport system, permease component
DL538_04305	COG1486	melibiose metabolic process
DL538_04310	COG2323	membrane
DL538_04315	COG2329	Antibiotic biosynthesis monooxygenase
DL538_04320	COG0346	lactoylglutathione lyase activity
DL538_04335	COG5583	Uncharacterized small protein (DUF2292)
DL538_04340	COG0670	Belongs to the BI1 family
DL538_04345	COG0697	spore germination
DL538_04350	COG1846	Transcriptional regulator
DL538_04355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DL538_04365	COG2124	cytochrome p450
DL538_04365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DL538_04375	COG1368	sulfuric ester hydrolase activity
DL538_04380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DL538_04385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DL538_04390	COG1442	glycosyl transferase family 8
DL538_04395	COG1216	Glycosyl transferase, family 2
DL538_04400	COG1442	glycosyl transferase family 8
DL538_04405	COG2223	nitrite transmembrane transporter activity
DL538_04410	COG1011	Hydrolase
DL538_04415	COG0531	amino acid
DL538_04420	COG1012	belongs to the aldehyde dehydrogenase family
DL538_04425	COG0840	transmembrane signaling receptor activity
DL538_04430	COG0488	(ABC) transporter
DL538_04440	COG0789	Transcriptional regulator
DL538_04445	COG2814	Major facilitator Superfamily
DL538_04460	COG0488	(ABC) transporter
DL538_04465	COG0513	Belongs to the DEAD box helicase family
DL538_04470	COG0456	acetyltransferase
DL538_04475	COG2130	NADP-dependent
DL538_04480	COG1120	ATPase activity
DL538_04485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_04490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_04495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DL538_04515	COG3866	Pectate lyase
DL538_04520	COG0471	metal ion transport
DL538_04525	COG3290	protein histidine kinase activity
DL538_04530	COG4565	transcriptional regulatory protein
DL538_04535	COG3181	Tripartite tricarboxylate transporter family receptor
DL538_04540	COG2851	Citrate transporter
DL538_04545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DL538_04550	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DL538_04555	COG1254	Belongs to the acylphosphatase family
DL538_04560	COG2258	MOSC domain
DL538_04580	COG0024	Methionine aminopeptidase
DL538_04585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_04585	COG1263	PTS System
DL538_04590	COG1368	sulfuric ester hydrolase activity
DL538_04605	COG1115	amino acid carrier protein
DL538_04610	COG0531	amino acid
DL538_04625	COG0697	spore germination
DL538_04630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_04630	COG1263	PTS System
DL538_04635	COG0366	Alpha amylase catalytic
DL538_04640	COG2188	Transcriptional regulator
DL538_04645	COG0778	Nitroreductase
DL538_04650	COG0737	Belongs to the 5'-nucleotidase family
DL538_04655	COG0693	protein deglycase activity
DL538_04660	COG2814	Major facilitator Superfamily
DL538_04665	COG4840	Belongs to the UPF0435 family
DL538_04670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DL538_04675	COG4980	gas vesicle protein
DL538_04680	COG1295	ribonuclease BN
DL538_04685	COG0477	Major facilitator Superfamily
DL538_04690	COG0387	Pfam Sodium calcium exchanger
DL538_04700	COG0668	transmembrane transport
DL538_04705	COG0535	radical SAM domain protein
DL538_04715	COG0726	polysaccharide deacetylase
DL538_04720	COG2084	Dehydrogenase
DL538_04725	COG0598	Magnesium transport protein CorA
DL538_04730	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DL538_04735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DL538_04745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DL538_04750	COG4637	Psort location Cytoplasmic, score
DL538_04760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DL538_04765	COG0022	dehydrogenase e1 component
DL538_04770	COG0508	dehydrogenase complex catalyzes the overall conversion of
DL538_04775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DL538_04780	COG3284	Transcriptional regulator
DL538_04790	COG1742	UPF0060 membrane protein
DL538_04815	COG4842	Belongs to the WXG100 family
DL538_04820	COG1486	melibiose metabolic process
DL538_04825	COG1737	Transcriptional regulator
DL538_04830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_04830	COG1263	PTS System
DL538_04835	COG1132	(ABC) transporter
DL538_04840	COG1132	(ABC) transporter
DL538_04845	COG2259	Doxx family
DL538_04850	COG2514	catechol 2,3-dioxygenase activity
DL538_04855	COG4585	Histidine kinase
DL538_04860	COG2197	response regulator
DL538_04865	COG1131	(ABC) transporter
DL538_04870	COG1511	domain protein
DL538_04870	COG0842	Transport permease protein
DL538_04875	COG0842	Transport permease protein
DL538_04880	COG1695	Transcriptional regulator
DL538_04885	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DL538_04890	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DL538_04895	COG2318	DinB family
DL538_04900	COG2814	Major facilitator Superfamily
DL538_04905	COG1846	Transcriptional regulator
DL538_04910	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DL538_04910	COG0392	lysyltransferase activity
DL538_04915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DL538_04920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_04925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_04930	COG0384	phenazine biosynthesis protein PhzF
DL538_04935	COG0778	Nitroreductase
DL538_04950	COG1090	epimerase
DL538_04955	COG2137	regulation of response to DNA damage stimulus
DL538_04965	COG2814	Major facilitator Superfamily
DL538_04980	COG3103	Sh3 type 3 domain protein
DL538_04985	COG5658	integral membrane protein
DL538_04990	COG0596	Alpha beta hydrolase
DL538_04995	COG0463	Glycosyl transferase, family 2
DL538_05000	COG4485	Bacterial membrane protein, YfhO
DL538_05005	COG1988	membrane-bound metal-dependent
DL538_05010	COG1194	a g-specific adenine glycosylase
DL538_05020	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_05035	COG3557	Belongs to the UPF0374 family
DL538_05040	COG1132	(ABC) transporter
DL538_05045	COG4129	membrane
DL538_05050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DL538_05055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DL538_05060	COG0735	belongs to the Fur family
DL538_05170	COG4326	sporulation control protein
DL538_05180	COG5577	PFAM Coat F domain
DL538_05185	COG3340	Belongs to the peptidase S51 family
DL538_05190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DL538_05195	COG0277	FAD linked oxidase domain protein
DL538_05205	COG0753	catalase activity
DL538_05210	COG1116	anion transmembrane transporter activity
DL538_05215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DL538_05220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DL538_05225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DL538_05235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DL538_05245	COG1476	TRANSCRIPTIONal
DL538_05255	COG3382	B3 4 domain protein
DL538_05260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DL538_05270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DL538_05275	COG0789	Transcriptional regulator
DL538_05280	COG1664	Polymer-forming cytoskeletal
DL538_05285	COG1664	Polymer-forming cytoskeletal
DL538_05290	COG2766	serine protein kinase
DL538_05295	COG2718	Belongs to the UPF0229 family
DL538_05300	COG1846	Transcriptional regulator
DL538_05305	COG1566	PFAM secretion protein HlyD family protein
DL538_05310	COG2814	Major facilitator Superfamily
DL538_05315	COG0655	NAD(P)H dehydrogenase (quinone) activity
DL538_05335	COG1725	Transcriptional regulator
DL538_05340	COG1131	(ABC) transporter
DL538_05345	COG1131	(ABC) transporter
DL538_05350	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DL538_05355	COG1278	Cold shock
DL538_05365	COG1464	Belongs to the NlpA lipoprotein family
DL538_05370	COG3706	GGDEF domain
DL538_05375	COG1823	symporter activity
DL538_05395	COG5577	PFAM Coat F domain
DL538_05400	COG4085	toxin activity
DL538_05400	COG1525	nuclease
DL538_05400	COG0737	Belongs to the 5'-nucleotidase family
DL538_05405	COG3764	Sortase (surface protein transpeptidase)
DL538_05410	COG0564	pseudouridine synthase activity
DL538_05420	COG0517	IMP dehydrogenase activity
DL538_05425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DL538_05430	COG3153	acetyltransferase
DL538_05430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DL538_05440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DL538_05445	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DL538_05450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DL538_05455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DL538_05460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DL538_05465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DL538_05470	COG4585	Histidine kinase
DL538_05470	COG2203	Gaf domain
DL538_05475	COG2197	response regulator
DL538_05480	COG0431	NADPH-dependent FMN reductase
DL538_05495	COG0791	NLP P60 protein
DL538_05495	COG1388	LysM domain
DL538_05500	COG1959	2 iron, 2 sulfur cluster binding
DL538_05505	COG0668	transmembrane transport
DL538_05510	COG2719	SpoVR family
DL538_05515	COG1785	Belongs to the alkaline phosphatase family
DL538_05520	COG0791	NLP P60 protein
DL538_05520	COG1388	LysM domain
DL538_05525	COG0583	DNA-binding transcription factor activity
DL538_05530	COG0372	Belongs to the citrate synthase family
DL538_05535	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_05540	COG0531	amino acid
DL538_05545	COG0733	neurotransmitter:sodium symporter activity
DL538_05550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DL538_05555	COG0456	acetyltransferase
DL538_05570	COG1595	DNA-templated transcription, initiation
DL538_05575	COG0667	Aldo Keto reductase
DL538_05580	COG0204	Acyl-transferase
DL538_05585	COG1253	flavin adenine dinucleotide binding
DL538_05590	COG0789	Transcriptional regulator
DL538_05595	COG0436	Aminotransferase
DL538_05600	COG1253	flavin adenine dinucleotide binding
DL538_05605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DL538_05610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DL538_05615	COG0584	glycerophosphoryl diester phosphodiesterase
DL538_05625	COG0668	transmembrane transport
DL538_05630	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DL538_05635	COG0726	polysaccharide deacetylase
DL538_05640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DL538_05645	COG1757	Na H antiporter
DL538_05650	COG0589	response to stress
DL538_05660	COG1132	(ABC) transporter
DL538_05665	COG1132	(ABC) transporter
DL538_05670	COG0702	epimerase
DL538_05690	COG0189	ligase activity
DL538_05695	COG0189	ligase activity
DL538_05700	COG4399	Belongs to the UPF0754 family
DL538_05705	COG3679	Belongs to the UPF0342 family
DL538_05710	COG4335	DNA alkylation repair
DL538_05715	COG0561	phosphatase activity
DL538_05720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DL538_05725	COG0475	glutathione-regulated potassium exporter activity
DL538_05730	COG0490	domain, Protein
DL538_05740	COG1024	Enoyl-CoA hydratase
DL538_05750	COG4152	abc transporter atp-binding protein
DL538_05755	COG1668	transmembrane transport
DL538_05760	COG0420	3'-5' exonuclease activity
DL538_05765	COG4717	serine-type aminopeptidase activity
DL538_05770	COG3481	metal-dependent phosphohydrolase, HD sub domain
DL538_05780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DL538_05810	COG1846	Transcriptional regulator
DL538_05815	COG4980	gas vesicle protein
DL538_05830	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DL538_05835	COG0537	adenosine 5'-monophosphoramidase activity
DL538_05840	COG1131	(ABC) transporter
DL538_05845	COG4473	ABC transporter
DL538_05855	COG1473	amidohydrolase
DL538_05860	COG3069	C4-dicarboxylate transmembrane transporter activity
DL538_05870	COG2329	Antibiotic biosynthesis monooxygenase
DL538_05875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DL538_05880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DL538_05895	COG1309	transcriptional regulator
DL538_05900	COG1511	domain protein
DL538_05905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DL538_05910	COG4377	Putative membrane peptidase family (DUF2324)
DL538_05920	COG1363	Peptidase, m42
DL538_05925	COG4405	Protein conserved in bacteria
DL538_05930	COG1301	dicarboxylic acid transport
DL538_05940	COG1234	tRNA 3'-trailer cleavage
DL538_05945	COG0095	Lipoate-protein ligase
DL538_05950	COG0702	epimerase
DL538_05955	COG0318	PFAM AMP-dependent synthetase and ligase
DL538_05965	COG0501	Belongs to the peptidase M48B family
DL538_05970	COG1404	Belongs to the peptidase S8 family
DL538_05975	COG0456	acetyltransferase
DL538_05980	COG0604	alcohol dehydrogenase
DL538_05985	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DL538_05990	COG0406	alpha-ribazole phosphatase activity
DL538_05995	COG0183	Belongs to the thiolase family
DL538_06000	COG0318	PFAM AMP-dependent synthetase and ligase
DL538_06005	COG1268	BioY protein
DL538_06010	COG0840	transmembrane signaling receptor activity
DL538_06015	COG0723	plastoquinol--plastocyanin reductase activity
DL538_06015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DL538_06020	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_06030	COG4903	ComK protein
DL538_06035	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_06045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DL538_06060	COG0398	Pfam SNARE associated Golgi protein
DL538_06065	COG0681	Belongs to the peptidase S26 family
DL538_06070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DL538_06075	COG1846	Transcriptional regulator
DL538_06080	COG0738	Major facilitator superfamily
DL538_06085	COG0673	inositol 2-dehydrogenase activity
DL538_06090	COG0561	phosphatase activity
DL538_06095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DL538_06100	COG1609	Transcriptional regulator
DL538_06105	COG3180	Ammonia monooxygenase
DL538_06110	COG2814	Major facilitator Superfamily
DL538_06110	COG0477	Major facilitator Superfamily
DL538_06115	COG4533	DNA binding
DL538_06125	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DL538_06130	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DL538_06135	COG1074	ATP-dependent DNA helicase activity
DL538_06140	COG0420	3'-5' exonuclease activity
DL538_06145	COG0419	ATPase involved in DNA repair
DL538_06150	COG1403	HNH endonuclease
DL538_06190	COG5337	Spore coat protein CotH
DL538_06195	COG0179	Fumarylacetoacetate (FAA) hydrolase
DL538_06205	COG1404	Belongs to the peptidase S8 family
DL538_06215	COG0367	asparagine synthase
DL538_06220	COG2318	DinB family
DL538_06225	COG1562	ergosterol biosynthetic process
DL538_06230	COG0534	Mate efflux family protein
DL538_06235	COG1917	Cupin 2, conserved barrel domain protein
DL538_06235	COG2207	Transcriptional regulator
DL538_06240	COG1609	Transcriptional regulator
DL538_06245	COG0673	inositol 2-dehydrogenase activity
DL538_06250	COG2318	DinB family
DL538_06255	COG1279	arginine transmembrane transporter activity
DL538_06260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DL538_06270	COG2267	carboxylic ester hydrolase activity
DL538_06275	COG0529	Catalyzes the synthesis of activated sulfate
DL538_06280	COG2046	Belongs to the sulfate adenylyltransferase family
DL538_06285	COG0175	sulfate reduction
DL538_06290	COG2045	Belongs to the ComB family
DL538_06295	COG1809	phosphosulfolactate synthase activity
DL538_06300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DL538_06305	COG4948	Mandelate Racemase Muconate Lactonizing
DL538_06310	COG2814	Major facilitator Superfamily
DL538_06315	COG0454	-acetyltransferase
DL538_06320	COG2153	protein acetylation
DL538_06325	COG0646	methionine synthase
DL538_06325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DL538_06330	COG1666	GTP binding
DL538_06335	COG2996	Protein conserved in bacteria
DL538_06355	COG1695	Transcriptional regulator
DL538_06370	COG3227	Zinc metalloprotease (Elastase)
DL538_06375	COG1307	EDD domain protein, DegV family
DL538_06380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DL538_06395	COG0561	phosphatase activity
DL538_06400	COG1073	alpha beta
DL538_06405	COG2151	metal-sulfur cluster biosynthetic enzyme
DL538_06415	COG0277	FAD linked oxidase domain protein
DL538_06420	COG2271	Major facilitator Superfamily
DL538_06425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DL538_06440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DL538_06445	COG0505	Belongs to the CarA family
DL538_06450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DL538_06455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DL538_06470	COG2267	carboxylic ester hydrolase activity
DL538_06480	COG1744	ABC transporter substrate-binding protein PnrA-like
DL538_06495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DL538_06500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DL538_06505	COG5504	Zn-dependent protease
DL538_06510	COG0444	Belongs to the ABC transporter superfamily
DL538_06515	COG4608	Belongs to the ABC transporter superfamily
DL538_06525	COG0601	transmembrane transport
DL538_06530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DL538_06540	COG0180	Tryptophanyl-tRNA synthetase
DL538_06545	COG4166	transmembrane transport
DL538_06550	COG0601	transmembrane transport
DL538_06555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DL538_06560	COG0444	Belongs to the ABC transporter superfamily
DL538_06565	COG4608	Belongs to the ABC transporter superfamily
DL538_06570	COG2814	Major facilitator Superfamily
DL538_06575	COG0456	acetyltransferase
DL538_06580	COG1393	Belongs to the ArsC family
DL538_06585	COG0861	Integral membrane protein TerC family
DL538_06590	COG4862	establishment of competence for transformation
DL538_06595	COG4469	Competence protein
DL538_06600	COG1164	Oligoendopeptidase f
DL538_06620	COG2346	COG2346, Truncated hemoglobins
DL538_06625	COG0741	lytic transglycosylase activity
DL538_06630	COG4116	CYTH
DL538_06640	COG2357	RelA SpoT domain protein
DL538_06645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DL538_06650	COG0564	pseudouridine synthase activity
DL538_06655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DL538_06660	COG0475	glutathione-regulated potassium exporter activity
DL538_06660	COG0569	domain protein
DL538_06665	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DL538_06670	COG0352	thiamine-phosphate diphosphorylase activity
DL538_06675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DL538_06680	COG2104	thiamine diphosphate biosynthetic process
DL538_06685	COG2022	thiamine diphosphate biosynthetic process
DL538_06690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DL538_06695	COG0351	phosphomethylpyrimidine kinase
DL538_06700	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DL538_06755	COG0210	DNA helicase
DL538_06765	COG2153	protein acetylation
DL538_06770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DL538_06775	COG2382	esterase
DL538_06780	COG0626	cystathionine gamma-synthase activity
DL538_06785	COG0626	cystathionine gamma-synthase activity
DL538_06790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DL538_06795	COG5505	Protein of unknown function (DUF819)
DL538_06825	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DL538_06830	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_06840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DL538_06840	COG3711	transcriptional antiterminator
DL538_06845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DL538_06845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DL538_06845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DL538_06850	COG1482	cell wall glycoprotein biosynthetic process
DL538_06860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DL538_06870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DL538_06890	COG0109	protoheme IX farnesyltransferase activity
DL538_06900	COG0726	polysaccharide deacetylase
DL538_06915	COG5504	Zn-dependent protease
DL538_06920	COG2205	protein histidine kinase activity
DL538_06930	COG3383	formate dehydrogenase (NAD+) activity
DL538_06935	COG2427	Protein of unknown function (DUF1641)
DL538_06945	COG1051	belongs to the nudix hydrolase family
DL538_06955	COG2124	cytochrome p450
DL538_06960	COG1819	glycosyl
DL538_06970	COG1587	Uroporphyrinogen-III synthase
DL538_06975	COG0390	transport system, permease component
DL538_06980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DL538_06985	COG0697	spore germination
DL538_06990	COG4297	protein containing double-stranded beta helix domain
DL538_07000	COG1252	NADH dehydrogenase
DL538_07005	COG1904	glucuronate isomerase
DL538_07010	COG2211	Major facilitator Superfamily
DL538_07015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DL538_07020	COG1063	alcohol dehydrogenase
DL538_07025	COG1312	Catalyzes the dehydration of D-mannonate
DL538_07030	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_07035	COG2271	Major facilitator Superfamily
DL538_07040	COG1609	Transcriptional regulator
DL538_07045	COG0246	Mannitol dehydrogenase
DL538_07050	COG2721	sulfolactate sulfo-lyase activity
DL538_07055	COG0730	response to heat
DL538_07060	COG2318	DinB family
DL538_07065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DL538_07070	COG0457	Tetratricopeptide repeat
DL538_07080	COG2350	Protein conserved in bacteria
DL538_07085	COG1388	LysM domain
DL538_07085	COG3409	Peptidoglycan-binding domain 1 protein
DL538_07085	COG5632	N-Acetylmuramoyl-L-alanine amidase
DL538_07095	COG4195	phage-related replication protein
DL538_07100	COG3546	catalase activity
DL538_07105	COG2856	Zn peptidase
DL538_07110	COG1396	sequence-specific DNA binding
DL538_07120	COG1522	sequence-specific DNA binding
DL538_07125	COG1484	DNA-dependent DNA replication
DL538_07145	COG1595	DNA-templated transcription, initiation
DL538_07150	COG3728	DNA packaging
DL538_07150	COG5484	DNA packaging
DL538_07155	COG1783	phage Terminase large subunit
DL538_07160	COG5518	Phage portal protein
DL538_07165	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DL538_07170	COG4653	Phage capsid family
DL538_07220	COG3953	SLT domain
DL538_07220	COG5412	phage tail tape measure protein
DL538_07225	COG1652	LysM domain
DL538_07230	COG4193	domain, Protein
DL538_07240	COG3628	GPW Gp25 family protein
DL538_07245	COG3299	homolog of phage Mu protein gp47
DL538_07250	COG3778	Protein conserved in bacteria
DL538_07290	COG5632	N-Acetylmuramoyl-L-alanine amidase
DL538_07290	COG3409	Peptidoglycan-binding domain 1 protein
DL538_07295	COG3594	Acyltransferase
DL538_07310	COG0306	phosphate transporter
DL538_07315	COG1392	Phosphate transport regulator
DL538_07320	COG0531	amino acid
DL538_07325	COG0346	lactoylglutathione lyase activity
DL538_07330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DL538_07335	COG0463	Glycosyl transferase, family 2
DL538_07345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DL538_07350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DL538_07355	COG2362	D-Aminopeptidase
DL538_07360	COG0601	transmembrane transport
DL538_07365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DL538_07370	COG0444	Belongs to the ABC transporter superfamily
DL538_07375	COG4166	transmembrane transport
DL538_07380	COG1619	proteins homologs of microcin C7 resistance protein MccF
DL538_07385	COG4948	Mandelate Racemase Muconate Lactonizing
DL538_07390	COG0791	NLP P60 protein
DL538_07395	COG4608	Belongs to the ABC transporter superfamily
DL538_07400	COG2706	6-phosphogluconolactonase activity
DL538_07405	COG1834	amidinotransferase
DL538_07410	COG1607	acyl-coa hydrolase
DL538_07415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DL538_07415	COG1017	nitric oxide dioxygenase activity
DL538_07425	COG2323	membrane
DL538_07430	COG2318	DinB family
DL538_07435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DL538_07440	COG2076	Multidrug Resistance protein
DL538_07445	COG2076	Multidrug Resistance protein
DL538_07450	COG0788	formyltetrahydrofolate deformylase activity
DL538_07455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DL538_07460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DL538_07465	COG1764	response to oxidative stress
DL538_07470	COG1846	Transcriptional regulator
DL538_07475	COG1764	response to oxidative stress
DL538_07480	COG0590	tRNA wobble adenosine to inosine editing
DL538_07485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DL538_07490	COG1404	Belongs to the peptidase S8 family
DL538_07495	COG1366	Belongs to the anti-sigma-factor antagonist family
DL538_07500	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DL538_07505	COG1122	ATPase activity
DL538_07510	COG4721	ABC-type cobalt transport system, permease component
DL538_07520	COG0745	RESPONSE REGULATOR receiver
DL538_07525	COG3850	Histidine kinase
DL538_07525	COG5002	protein histidine kinase activity
DL538_07530	COG3212	peptidase
DL538_07535	COG3212	peptidase
DL538_07550	COG2239	Acts as a magnesium transporter
DL538_07555	COG0789	Transcriptional regulator
DL538_07570	COG1846	Transcriptional regulator
DL538_07575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DL538_07580	COG0726	polysaccharide deacetylase
DL538_07585	COG1408	metallophosphoesterase
DL538_07595	COG0463	Glycosyl transferase, family 2
DL538_07600	COG3285	dna ligase
DL538_07600	COG1793	dna ligase
DL538_07605	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DL538_07610	COG3300	MHYT domain
DL538_07610	COG5001	Diguanylate cyclase
DL538_07615	COG0586	Pfam SNARE associated Golgi protein
DL538_07620	COG0861	Integral membrane protein TerC family
DL538_07625	COG1191	sigma factor activity
DL538_07645	COG0501	Belongs to the peptidase M48B family
DL538_07650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DL538_07665	COG3594	Acyltransferase
DL538_07670	COG5002	protein histidine kinase activity
DL538_07675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DL538_07680	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DL538_07685	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DL538_07690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DL538_07695	COG0436	Aminotransferase
DL538_07700	COG1850	ribulose-bisphosphate carboxylase activity
DL538_07705	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DL538_07710	COG0235	Class ii aldolase
DL538_07715	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DL538_07720	COG3339	Conserved Protein
DL538_07735	COG3852	Histidine kinase
DL538_07740	COG1846	Transcriptional regulator
DL538_07745	COG1360	Flagellar Motor Protein
DL538_07750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DL538_07755	COG0542	response to heat
DL538_07760	COG3949	Membrane
DL538_07765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DL538_07770	COG0720	synthase
DL538_07775	COG0602	queuosine metabolic process
DL538_07780	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DL538_07785	COG1733	regulation of RNA biosynthetic process
DL538_07790	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_07795	COG1388	LysM domain
DL538_07795	COG4641	Protein conserved in bacteria
DL538_07800	COG1388	LysM domain
DL538_07805	COG3858	chitin binding
DL538_07810	COG3858	chitin binding
DL538_07820	COG4873	Protein conserved in bacteria
DL538_07830	COG3773	Cell wall hydrolase
DL538_07835	COG2244	polysaccharide biosynthetic process
DL538_07840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_07845	COG2217	Heavy metal translocating P-type atpase
DL538_07855	COG0006	proline dipeptidase activity
DL538_07860	COG1609	Transcriptional regulator
DL538_07865	COG3711	transcriptional antiterminator
DL538_07870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_07870	COG2190	(PTS) system
DL538_07870	COG1263	PTS System
DL538_07875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DL538_07880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DL538_07890	COG1533	DNA photolyase activity
DL538_07895	COG0456	acetyltransferase
DL538_07900	COG0840	transmembrane signaling receptor activity
DL538_07905	COG2084	Dehydrogenase
DL538_07910	COG2340	Cysteine-rich secretory protein family
DL538_07915	COG0768	penicillin binding
DL538_07920	COG4191	Histidine kinase
DL538_07925	COG0436	Aminotransferase
DL538_07935	COG0835	chemotaxis
DL538_07935	COG0784	Response regulator, receiver
DL538_07945	COG2814	Major facilitator Superfamily
DL538_07950	COG1376	ErfK ybiS ycfS ynhG family protein
DL538_07955	COG1408	metallophosphoesterase
DL538_07960	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_07965	COG3409	Peptidoglycan-binding domain 1 protein
DL538_07975	COG2200	EAL domain
DL538_07980	COG4703	Protein of unknown function (DUF1797)
DL538_07985	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DL538_07995	COG0517	IMP dehydrogenase activity
DL538_08000	COG0583	DNA-binding transcription factor activity
DL538_08005	COG0716	FMN binding
DL538_08015	COG0716	FMN binding
DL538_08020	COG2171	N-acyltransferase activity
DL538_08025	COG1473	amidohydrolase
DL538_08035	COG0668	transmembrane transport
DL538_08040	COG0450	alkyl hydroperoxide reductase
DL538_08045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_08060	COG0746	molybdenum cofactor guanylyltransferase activity
DL538_08065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DL538_08070	COG0303	'Molybdopterin
DL538_08075	COG1763	Mo-molybdopterin cofactor biosynthetic process
DL538_08080	COG0314	molybdopterin synthase activity
DL538_08085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DL538_08090	COG1132	(ABC) transporter
DL538_08095	COG1132	(ABC) transporter
DL538_08105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DL538_08110	COG1136	(ABC) transporter
DL538_08115	COG0577	efflux transmembrane transporter activity
DL538_08120	COG1349	DNA-binding transcription factor activity
DL538_08125	COG1105	Belongs to the carbohydrate kinase PfkB family
DL538_08130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DL538_08130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DL538_08130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DL538_08135	COG0681	Belongs to the peptidase S26 family
DL538_08145	COG0488	(ABC) transporter
DL538_08150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DL538_08155	COG2309	aminopeptidase activity
DL538_08165	COG1077	Cell shape determining protein MreB Mrl
DL538_08170	COG2002	toxin-antitoxin pair type II binding
DL538_08175	COG3852	Histidine kinase
DL538_08180	COG2105	PFAM AIG2 family protein
DL538_08180	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DL538_08185	COG0569	domain protein
DL538_08190	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DL538_08195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DL538_08205	COG0561	phosphatase activity
DL538_08210	COG0242	peptide deformylase activity
DL538_08220	COG0497	DNA recombination
DL538_08225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DL538_08230	COG0022	dehydrogenase e1 component
DL538_08235	COG0508	dehydrogenase complex catalyzes the overall conversion of
DL538_08240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DL538_08245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_08255	COG1982	Orn Lys Arg decarboxylase major
DL538_08260	COG4476	Belongs to the UPF0223 family
DL538_08265	COG4493	Belongs to the UPF0637 family
DL538_08275	COG0483	inositol monophosphate 1-phosphatase activity
DL538_08285	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DL538_08305	COG1595	DNA-templated transcription, initiation
DL538_08335	COG4896	Protein conserved in bacteria
DL538_08345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DL538_08350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DL538_08355	COG2066	Belongs to the glutaminase family
DL538_08360	COG4838	Belongs to the UPF0358 family
DL538_08365	COG0772	Belongs to the SEDS family
DL538_08370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DL538_08375	COG1612	heme a metabolic process
DL538_08380	COG0109	protoheme IX farnesyltransferase activity
DL538_08385	COG2010	Cytochrome c
DL538_08385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DL538_08390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DL538_08395	COG1845	cytochrome c oxidase, subunit III
DL538_08400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DL538_08405	COG3336	cytochrome c oxidase
DL538_08415	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DL538_08420	COG2340	Cysteine-rich secretory protein family
DL538_08435	COG3679	Belongs to the UPF0342 family
DL538_08440	COG4471	UPF0298 protein
DL538_08445	COG0742	ribosomal rna small subunit methyltransferase
DL538_08450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DL538_08455	COG3314	Sporulation integral membrane protein YlbJ
DL538_08460	COG1752	Esterase of the alpha-beta hydrolase superfamily
DL538_08465	COG3480	Lon protease (S16) C-terminal proteolytic domain
DL538_08485	COG1399	metal-binding, possibly nucleic acid-binding protein
DL538_08490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DL538_08500	COG0454	-acetyltransferase
DL538_08505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DL538_08510	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DL538_08515	COG2001	Belongs to the MraZ family
DL538_08520	COG0275	rRNA processing
DL538_08525	COG4839	cell division protein FtsL
DL538_08535	COG0768	penicillin binding
DL538_08540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DL538_08545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DL538_08565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DL538_08570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DL538_08575	COG3879	Bacterial protein of unknown function (DUF881)
DL538_08580	COG3879	Bacterial protein of unknown function (DUF881)
DL538_08585	COG3856	small basic protein
DL538_08590	COG0849	cell division
DL538_08595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DL538_08615	COG1404	Belongs to the peptidase S8 family
DL538_08615	COG4412	M6 family metalloprotease domain protein
DL538_08625	COG1191	sigma factor activity
DL538_08630	COG1191	sigma factor activity
DL538_08635	COG1119	ATPase activity
DL538_08640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DL538_08645	COG1873	PFAM PRC-barrel domain
DL538_08655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DL538_08660	COG1799	cell septum assembly
DL538_08665	COG0762	integral membrane protein
DL538_08670	COG2302	S4 RNA-binding domain
DL538_08675	COG3599	regulation of cell shape
DL538_08680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DL538_08685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DL538_08690	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DL538_08695	COG0564	pseudouridine synthase activity
DL538_08700	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DL538_08705	COG2233	PERMEase
DL538_08710	COG0540	Belongs to the ATCase OTCase family
DL538_08715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DL538_08720	COG0505	Belongs to the CarA family
DL538_08725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DL538_08730	COG0543	2 iron, 2 sulfur cluster binding
DL538_08735	COG0167	dihydroorotate dehydrogenase activity
DL538_08740	COG0284	orotidine-5'-phosphate decarboxylase activity
DL538_08745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DL538_08750	COG0175	sulfate reduction
DL538_08755	COG0306	phosphate transporter
DL538_08760	COG2046	Belongs to the sulfate adenylyltransferase family
DL538_08765	COG0529	Catalyzes the synthesis of activated sulfate
DL538_08770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DL538_08775	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DL538_08780	COG1648	precorrin-2 dehydrogenase activity
DL538_08790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DL538_08795	COG1561	YicC-like family, N-terminal region
DL538_08800	COG2052	Domain of unknown function (DUF370)
DL538_08805	COG0194	GDP metabolic process
DL538_08810	COG1758	RNA polymerase activity
DL538_08815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DL538_08820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DL538_08825	COG0242	peptide deformylase activity
DL538_08830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DL538_08835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DL538_08835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DL538_08840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DL538_08845	COG0631	protein serine/threonine phosphatase activity
DL538_08850	COG2815	serine threonine protein kinase
DL538_08850	COG0515	serine threonine protein kinase
DL538_08855	COG1162	GTPase activity
DL538_08860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DL538_08865	COG1564	THIamine pyrophosphokinase
DL538_08875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DL538_08880	COG1302	Protein conserved in bacteria
DL538_08885	COG1461	Dihydroxyacetone kinase
DL538_08890	COG1760	l-serine dehydratase
DL538_08895	COG1760	l-serine dehydratase
DL538_08900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DL538_08905	COG1349	DNA-binding transcription factor activity
DL538_08905	COG2050	protein possibly involved in aromatic compounds catabolism
DL538_08910	COG0416	fatty acid biosynthetic process
DL538_08915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DL538_08920	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_08925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DL538_08930	COG0571	ribonuclease III activity
DL538_08935	COG1196	nuclear chromosome segregation
DL538_08940	COG0552	protein localization to endoplasmic reticulum
DL538_08950	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DL538_08955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DL538_08960	COG0228	four-way junction DNA binding
DL538_08965	COG1837	Belongs to the UPF0109 family
DL538_08975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DL538_08980	COG0336	Belongs to the RNA methyltransferase TrmD family
DL538_08985	COG0335	large ribosomal subunit rRNA binding
DL538_08990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DL538_08995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DL538_09005	COG2257	FlhB HrpN YscU SpaS Family
DL538_09010	COG0045	succinate-CoA ligase (ADP-forming) activity
DL538_09015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DL538_09020	COG0758	DNA mediated transformation
DL538_09025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DL538_09030	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DL538_09035	COG4974	Belongs to the 'phage' integrase family
DL538_09040	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DL538_09045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DL538_09050	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DL538_09055	COG1815	bacterial-type flagellum-dependent cell motility
DL538_09060	COG1558	bacterial-type flagellum-dependent cell motility
DL538_09065	COG1677	Flagellar hook-basal body complex protein FliE
DL538_09070	COG1766	The M ring may be actively involved in energy transduction
DL538_09075	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DL538_09080	COG1317	bacterial-type flagellum organization
DL538_09085	COG1157	protein secretion by the type III secretion system
DL538_09090	COG2882	bacterial-type flagellum organization
DL538_09095	COG3334	PFAM MgtE intracellular
DL538_09100	COG3144	bacterial-type flagellum assembly
DL538_09105	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DL538_09110	COG4786	Flagellar basal body rod
DL538_09115	COG1582	Flagellar protein (FlbD)
DL538_09120	COG1580	Controls the rotational direction of flagella during chemotaxis
DL538_09125	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DL538_09130	COG1776	CheC inhibitor of MCP methylation
DL538_09130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DL538_09135	COG2201	protein-glutamate methylesterase activity
DL538_09140	COG3190	flagellar
DL538_09145	COG1338	Plays a role in the flagellum-specific transport system
DL538_09150	COG1987	bacterial-type flagellum assembly
DL538_09155	COG1684	flagellar biosynthetic protein fliR
DL538_09160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DL538_09165	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DL538_09170	COG1419	protein localization to endoplasmic reticulum
DL538_09175	COG0455	bacterial-type flagellum organization
DL538_09180	COG2201	protein-glutamate methylesterase activity
DL538_09185	COG0643	Histidine kinase
DL538_09185	COG2198	Histidine kinase
DL538_09190	COG0835	chemotaxis
DL538_09195	COG1776	CheC inhibitor of MCP methylation
DL538_09200	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DL538_09205	COG1191	sigma factor activity
DL538_09215	COG0052	Belongs to the universal ribosomal protein uS2 family
DL538_09220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DL538_09225	COG0528	UMP kinase activity
DL538_09230	COG0233	cytoplasmic translational termination
DL538_09235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DL538_09240	COG4589	Belongs to the CDS family
DL538_09245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DL538_09250	COG0750	zinc metalloprotease
DL538_09255	COG0442	prolyl-tRNA aminoacylation
DL538_09260	COG2176	DNA-directed DNA polymerase activity
DL538_09265	COG0779	Required for maturation of 30S ribosomal subunits
DL538_09270	COG0195	Participates in both transcription termination and antitermination
DL538_09275	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DL538_09280	COG1358	cellular component organization or biogenesis
DL538_09285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DL538_09290	COG1550	Protein conserved in bacteria
DL538_09295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DL538_09300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DL538_09305	COG0196	riboflavin kinase activity
DL538_09310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DL538_09315	COG1185	polyribonucleotide nucleotidyltransferase activity
DL538_09320	COG0726	polysaccharide deacetylase
DL538_09325	COG0612	Peptidase, M16
DL538_09330	COG1873	PFAM PRC-barrel domain
DL538_09335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DL538_09340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DL538_09345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DL538_09350	COG0527	aspartate kinase activity
DL538_09355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DL538_09360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DL538_09365	COG0740	serine-type endopeptidase activity
DL538_09375	COG4980	gas vesicle protein
DL538_09375	COG1674	ftsk spoiiie
DL538_09380	COG2188	Transcriptional regulator
DL538_09385	COG2814	Major facilitator Superfamily
DL538_09390	COG0612	Peptidase, M16
DL538_09395	COG0612	Peptidase, M16
DL538_09400	COG0300	oxidoreductase activity
DL538_09415	COG1426	Protein conserved in bacteria
DL538_09420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DL538_09425	COG1058	Belongs to the CinA family
DL538_09425	COG1546	Belongs to the CinA family
DL538_09430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DL538_09435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DL538_09440	COG1418	mRNA catabolic process
DL538_09445	COG1692	metallophosphoesterase
DL538_09450	COG2359	stage V sporulation protein S
DL538_09455	COG1063	alcohol dehydrogenase
DL538_09460	COG0156	8-amino-7-oxononanoate synthase activity
DL538_09465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DL538_09470	COG4550	Control of competence regulator ComK, YlbF/YmcA
DL538_09480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DL538_09485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DL538_09500	COG3226	Transcriptional regulator
DL538_09505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DL538_09515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DL538_09520	COG3321	synthase
DL538_09525	COG2070	2-Nitropropane dioxygenase
DL538_09525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DL538_09530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DL538_09535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DL538_09540	COG3425	synthase
DL538_09545	COG1024	Enoyl-CoA hydratase
DL538_09550	COG1024	Enoyl-CoA hydratase
DL538_09555	COG3321	synthase
DL538_09555	COG0300	oxidoreductase activity
DL538_09555	COG0318	PFAM AMP-dependent synthetase and ligase
DL538_09555	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_09555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_09560	COG3321	synthase
DL538_09560	COG4221	oxidoreductase activity
DL538_09560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DL538_09560	COG0300	oxidoreductase activity
DL538_09565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DL538_09565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DL538_09565	COG3321	synthase
DL538_09565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_09565	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_09570	COG4221	oxidoreductase activity
DL538_09570	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_09570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_09570	COG3321	synthase
DL538_09575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DL538_09575	COG3321	synthase
DL538_09575	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DL538_09575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DL538_09580	COG2124	cytochrome p450
DL538_09590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DL538_09595	COG1404	Belongs to the peptidase S8 family
DL538_09605	COG4195	phage-related replication protein
DL538_09610	COG1764	response to oxidative stress
DL538_09615	COG2076	Multidrug Resistance protein
DL538_09620	COG2076	Multidrug Resistance protein
DL538_09635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DL538_09640	COG1923	regulation of RNA biosynthetic process
DL538_09655	COG1780	Probably involved in ribonucleotide reductase function
DL538_09660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DL538_09665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DL538_09670	COG4112	unkown
DL538_09675	COG0860	N-Acetylmuramoyl-L-alanine amidase
DL538_09685	COG0464	growth
DL538_09690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DL538_09695	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DL538_09700	COG0789	Transcriptional regulator
DL538_09705	COG0174	glutamine synthetase
DL538_09730	COG3409	Peptidoglycan-binding domain 1 protein
DL538_09730	COG5632	N-Acetylmuramoyl-L-alanine amidase
DL538_09740	COG5444	nuclease activity
DL538_09815	COG4282	regulation of fungal-type cell wall biogenesis
DL538_09830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DL538_09845	COG3655	Transcriptional regulator
DL538_09870	COG0135	phosphoribosylanthranilate isomerase activity
DL538_09875	COG2211	Major facilitator Superfamily
DL538_09880	COG3507	Belongs to the glycosyl hydrolase 43 family
DL538_09885	COG1940	carbohydrate kinase activity
DL538_09890	COG2115	Belongs to the xylose isomerase family
DL538_09895	COG1070	Carbohydrate kinase
DL538_09905	COG1525	nuclease
DL538_09910	COG2814	Major facilitator Superfamily
DL538_09915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DL538_09925	COG0756	dUTP diphosphatase activity
DL538_09960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DL538_09970	COG3832	glyoxalase III activity
DL538_09980	COG0697	spore germination
DL538_09985	COG0531	amino acid
DL538_10015	COG4195	phage-related replication protein
DL538_10025	COG0346	lactoylglutathione lyase activity
DL538_10035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DL538_10040	COG1388	LysM domain
DL538_10045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DL538_10050	COG4224	UPF0291 protein
DL538_10055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DL538_10065	COG3763	UPF0154 protein
DL538_10075	COG0785	Cytochrome C biogenesis protein
DL538_10080	COG2201	protein-glutamate methylesterase activity
DL538_10085	COG4846	Membrane protein involved in cytochrome C biogenesis
DL538_10095	COG0071	Belongs to the small heat shock protein (HSP20) family
DL538_10110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DL538_10115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_10135	COG0824	Thioesterase
DL538_10145	COG4841	protein insertion into membrane
DL538_10150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DL538_10155	COG1832	CoA-binding protein
DL538_10160	COG0187	DNA topoisomerase II activity
DL538_10165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DL538_10175	COG1115	amino acid carrier protein
DL538_10180	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DL538_10190	COG5520	Belongs to the glycosyl hydrolase 30 family
DL538_10195	COG3507	Belongs to the glycosyl hydrolase 43 family
DL538_10205	COG2246	polysaccharide biosynthetic process
DL538_10210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DL538_10215	COG0586	Pfam SNARE associated Golgi protein
DL538_10220	COG2404	hydrolase activity, acting on ester bonds
DL538_10225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DL538_10230	COG1024	Enoyl-CoA hydratase
DL538_10235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DL538_10240	COG0511	ligase activity, forming carbon-carbon bonds
DL538_10245	COG0439	Biotin carboxylase
DL538_10250	COG0318	PFAM AMP-dependent synthetase and ligase
DL538_10255	COG1960	acyl-CoA dehydrogenase activity
DL538_10260	COG1649	PFAM Uncharacterised BCR, COG1649
DL538_10270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_10270	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DL538_10275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_10280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_10285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_10290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_10295	COG2027	D-alanyl-D-alanine carboxypeptidase
DL538_10300	COG2017	converts alpha-aldose to the beta-anomer
DL538_10305	COG0534	Mate efflux family protein
DL538_10320	COG0582	viral genome integration into host DNA
DL538_10325	COG0166	Belongs to the GPI family
DL538_10330	COG0405	Gamma-glutamyltransferase
DL538_10335	COG0583	DNA-binding transcription factor activity
DL538_10340	COG0604	alcohol dehydrogenase
DL538_10345	COG0493	'glutamate synthase
DL538_10350	COG0070	glutamate synthase
DL538_10350	COG0069	glutamate synthase activity
DL538_10350	COG0067	glutamate synthase
DL538_10355	COG0583	DNA-binding transcription factor activity
DL538_10360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DL538_10365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DL538_10375	COG0300	oxidoreductase activity
DL538_10380	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DL538_10390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DL538_10395	COG2814	Major facilitator Superfamily
DL538_10400	COG1070	Carbohydrate kinase
DL538_10405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DL538_10410	COG0243	molybdopterin cofactor binding
DL538_10420	COG2814	Major facilitator Superfamily
DL538_10425	COG0673	inositol 2-dehydrogenase activity
DL538_10430	COG1082	Xylose isomerase domain protein TIM barrel
DL538_10435	COG1609	Transcriptional regulator
DL538_10455	COG0840	transmembrane signaling receptor activity
DL538_10455	COG5278	phosphoserine phosphatase activity
DL538_10460	COG2368	4-hydroxyphenylacetate
DL538_10465	COG4305	rare lipoprotein A
DL538_10470	COG3619	membrane
DL538_10475	COG3866	Pectate lyase
DL538_10480	COG2135	peptidase activity
DL538_10490	COG2140	Oxalate decarboxylase
DL538_10500	COG0456	acetyltransferase
DL538_10520	COG2720	vancomycin resistance protein
DL538_10530	COG3655	Transcriptional regulator
DL538_10535	COG3739	integral membrane protein
DL538_10540	COG0583	DNA-binding transcription factor activity
DL538_10545	COG0697	spore germination
DL538_10555	COG0693	protein deglycase activity
DL538_10560	COG2367	Beta-lactamase
DL538_10580	COG0574	Belongs to the PEP-utilizing enzyme family
DL538_10580	COG3848	Pyruvate phosphate dikinase
DL538_10585	COG0726	polysaccharide deacetylase
DL538_10655	COG1404	Belongs to the peptidase S8 family
DL538_10685	COG0457	Tetratricopeptide repeat
DL538_10700	COG4282	regulation of fungal-type cell wall biogenesis
DL538_10705	COG1231	oxidoreductase activity
DL538_10710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DL538_10715	COG2207	Transcriptional regulator
DL538_10715	COG0662	Cupin 2, conserved barrel domain protein
DL538_10720	COG0456	acetyltransferase
DL538_10725	COG1309	transcriptional regulator
DL538_10730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DL538_10735	COG3708	Transcriptional regulator
DL538_10740	COG2378	regulation of single-species biofilm formation
DL538_10750	COG0640	Transcriptional regulator
DL538_10755	COG0741	lytic transglycosylase activity
DL538_10760	COG2322	membrane
DL538_10775	COG1619	proteins homologs of microcin C7 resistance protein MccF
DL538_10780	COG3239	Fatty acid desaturase
DL538_10785	COG4585	Histidine kinase
DL538_10790	COG2197	response regulator
DL538_10795	COG1388	LysM domain
DL538_10795	COG3584	3D domain protein
DL538_10800	COG0514	ATP-dependent DNA helicase (RecQ)
DL538_10815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DL538_10820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DL538_10835	COG0071	Belongs to the small heat shock protein (HSP20) family
DL538_10860	COG1012	belongs to the aldehyde dehydrogenase family
DL538_10865	COG1657	PFAM Prenyltransferase squalene oxidase
DL538_10870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DL538_10875	COG0733	neurotransmitter:sodium symporter activity
DL538_10880	COG0385	Bile acid
DL538_10885	COG0508	dehydrogenase complex catalyzes the overall conversion of
DL538_10890	COG0567	Dehydrogenase, E1 component
DL538_10895	COG4548	von Willebrand factor, type A
DL538_10900	COG0714	Associated with various cellular activities
DL538_10905	COG2032	superoxide dismutase activity
DL538_10910	COG0791	NLP P60 protein
DL538_10910	COG1388	LysM domain
DL538_10915	COG1819	glycosyl
DL538_10920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DL538_10925	COG0534	Mate efflux family protein
DL538_10930	COG1366	Belongs to the anti-sigma-factor antagonist family
DL538_10935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DL538_10940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DL538_10950	COG2962	Rard protein
DL538_10965	COG2610	gluconate transmembrane transporter activity
DL538_10970	COG1942	4-Oxalocrotonate Tautomerase
DL538_10975	COG1733	regulation of RNA biosynthetic process
DL538_10980	COG0778	Nitroreductase
DL538_10985	COG0400	carboxylic ester hydrolase activity
DL538_10990	COG0346	lactoylglutathione lyase activity
DL538_11000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DL538_11005	COG3409	Peptidoglycan-binding domain 1 protein
DL538_11005	COG0793	Belongs to the peptidase S41A family
DL538_11010	COG2226	methyltransferase
DL538_11020	COG1876	peptidase activity
DL538_11025	COG0813	purine-nucleoside phosphorylase activity
DL538_11040	COG0671	phosphoesterase, PA-phosphatase related
DL538_11065	COG4479	Belongs to the UPF0346 family
DL538_11075	COG1509	lysine 2,3-aminomutase activity
DL538_11080	COG0456	acetyltransferase
DL538_11085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DL538_11090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DL538_11095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DL538_11100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DL538_11110	COG0456	acetyltransferase
DL538_11115	COG0463	Glycosyl transferase, family 2
DL538_11130	COG4641	Protein conserved in bacteria
DL538_11135	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
DL538_11140	COG1086	Polysaccharide biosynthesis protein
DL538_11145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DL538_11150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DL538_11155	COG1846	Transcriptional regulator
DL538_11160	COG0534	Mate efflux family protein
DL538_11170	COG4698	Protein conserved in bacteria
DL538_11175	COG2755	lipolytic protein G-D-S-L family
DL538_11180	COG1999	signal sequence binding
DL538_11190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DL538_11195	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DL538_11200	COG1272	protein, Hemolysin III
DL538_11205	COG0204	Acyl-transferase
DL538_11210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DL538_11215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DL538_11220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DL538_11230	COG2136	Putative SAM-dependent methyltransferase
DL538_11230	COG2521	methyltransferase
DL538_11240	COG0129	dihydroxy-acid dehydratase activity
DL538_11245	COG1413	lyase activity
DL538_11250	COG1418	mRNA catabolic process
DL538_11255	COG0386	Belongs to the glutathione peroxidase family
DL538_11260	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DL538_11265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DL538_11270	COG1278	Cold shock
DL538_11290	COG0328	RNA-DNA hybrid ribonuclease activity
DL538_11295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DL538_11300	COG0328	RNA-DNA hybrid ribonuclease activity
DL538_11310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DL538_11325	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DL538_11335	COG1755	Isoprenylcysteine carboxyl methyltransferase
DL538_11340	COG3424	synthase
DL538_11345	COG2233	PERMEase
DL538_11350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DL538_11355	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DL538_11365	COG0800	Aldolase
DL538_11370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DL538_11375	COG1609	Transcriptional regulator
DL538_11380	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DL538_11385	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_11390	COG1199	ATP-dependent helicase activity
DL538_11405	COG0116	Belongs to the methyltransferase superfamily
DL538_11420	COG4474	Belongs to the UPF0398 family
DL538_11430	COG3359	exonuclease
DL538_11435	COG1111	helicase
DL538_11435	COG1205	dead DEAH box helicase
DL538_11440	COG2190	(PTS) system
DL538_11445	COG0071	Belongs to the small heat shock protein (HSP20) family
DL538_11480	COG3331	DNA recombination
DL538_11485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DL538_11485	COG4499	WXG100 protein secretion system (Wss), protein YukC
DL538_11495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DL538_11500	COG3935	DnaD domain protein
DL538_11505	COG0017	Asparaginyl-tRNA synthetase
DL538_11510	COG0436	Aminotransferase
DL538_11515	COG5353	protein conserved in bacteria
DL538_11525	COG1199	ATP-dependent helicase activity
DL538_11525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DL538_11530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DL538_11535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DL538_11540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DL538_11545	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DL538_11545	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DL538_11550	COG0617	tRNA 3'-terminal CCA addition
DL538_11555	COG0438	transferase activity, transferring glycosyl groups
DL538_11560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DL538_11565	COG1803	Methylglyoxal synthase
DL538_11570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DL538_11575	COG1694	Mazg nucleotide pyrophosphohydrolase
DL538_11580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DL538_11590	COG4347	Protein of unknown function (DUF1405)
DL538_11595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DL538_11595	COG2010	Cytochrome c
DL538_11600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DL538_11605	COG0723	plastoquinol--plastocyanin reductase activity
DL538_11615	COG5582	Belongs to the UPF0302 family
DL538_11620	COG0457	Tetratricopeptide repeat
DL538_11625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DL538_11630	COG0287	Prephenate dehydrogenase
DL538_11640	COG0159	tryptophan synthase activity
DL538_11645	COG0133	tryptophan synthase activity
DL538_11650	COG0135	phosphoribosylanthranilate isomerase activity
DL538_11660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DL538_11665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DL538_11670	COG4401	Chorismate mutase type I
DL538_11675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DL538_11680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DL538_11685	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DL538_11690	COG0105	UTP biosynthetic process
DL538_11695	COG0142	geranyltranstransferase activity
DL538_11700	COG2226	methyltransferase
DL538_11705	COG0142	geranyltranstransferase activity
DL538_11715	COG0302	gtp cyclohydrolase
DL538_11720	COG0776	regulation of translation
DL538_11725	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DL538_11740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DL538_11745	COG1160	GTP binding
DL538_11770	COG1304	FMN binding
DL538_11775	COG0539	negative regulation of cytoplasmic translation
DL538_11780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DL538_11790	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DL538_11795	COG2959	enzyme of heme biosynthesis
DL538_11800	COG3773	Cell wall hydrolase
DL538_11800	COG3409	Peptidoglycan-binding domain 1 protein
DL538_11805	COG2339	peptidase activity
DL538_11810	COG0492	ferredoxin-NADP+ reductase activity
DL538_11815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DL538_11820	COG4862	establishment of competence for transformation
DL538_11825	COG1408	metallophosphoesterase
DL538_11835	COG1388	LysM domain
DL538_11840	COG1266	CAAX protease self-immunity
DL538_11845	COG0514	ATP-dependent DNA helicase (RecQ)
DL538_11850	COG4955	Helix-turn-helix domain
DL538_11855	COG1141	Ferredoxin
DL538_11860	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DL538_11865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DL538_11870	COG0710	3-dehydroquinate dehydratase activity
DL538_11880	COG1595	DNA-templated transcription, initiation
DL538_11885	COG5002	protein histidine kinase activity
DL538_11890	COG0745	RESPONSE REGULATOR receiver
DL538_11895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DL538_11900	COG1333	cytochrome c biogenesis protein
DL538_11905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_11910	COG1187	pseudouridine synthase activity
DL538_11915	COG0700	Nucleoside recognition
DL538_11920	COG2715	membrane protein required for spore maturation
DL538_11925	COG1686	Belongs to the peptidase S11 family
DL538_11935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DL538_11940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DL538_11945	COG1547	Domain of unknown function (DUF309)
DL538_11950	COG0456	acetyltransferase
DL538_11955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DL538_11960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DL538_11960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DL538_11965	COG0307	riboflavin synthase, alpha
DL538_11970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DL538_11970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DL538_11980	COG0681	Belongs to the peptidase S26 family
DL538_11990	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DL538_12045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DL538_12055	COG4086	secreted protein
DL538_12060	COG0019	diaminopimelate decarboxylase activity
DL538_12065	COG0697	spore germination
DL538_12080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DL538_12100	COG1191	sigma factor activity
DL538_12105	COG2172	sigma factor antagonist activity
DL538_12110	COG1366	Belongs to the anti-sigma-factor antagonist family
DL538_12115	COG1686	Belongs to the peptidase S11 family
DL538_12120	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DL538_12125	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DL538_12130	COG4974	Belongs to the 'phage' integrase family
DL538_12140	COG0735	belongs to the Fur family
DL538_12145	COG1300	Membrane
DL538_12155	COG0281	malic enzyme
DL538_12160	COG1757	Na H antiporter
DL538_12165	COG1027	Aspartate ammonia-lyase
DL538_12170	COG0252	asparaginase activity
DL538_12175	COG1396	sequence-specific DNA binding
DL538_12180	COG1379	DNA repair
DL538_12185	COG0494	nUDIX hydrolase
DL538_12195	COG0667	Aldo Keto reductase
DL538_12205	COG1073	alpha beta
DL538_12215	COG4918	Iron-sulphur cluster biosynthesis
DL538_12220	COG0456	acetyltransferase
DL538_12220	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DL538_12225	COG2329	Antibiotic biosynthesis monooxygenase
DL538_12230	COG0456	acetyltransferase
DL538_12240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DL538_12250	COG2211	Major facilitator Superfamily
DL538_12260	COG0346	lactoylglutathione lyase activity
DL538_12265	COG1072	(Pantothenic acid kinase))
DL538_12270	COG3048	D-serine ammonia-lyase activity
DL538_12275	COG0300	oxidoreductase activity
DL538_12280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DL538_12285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DL538_12290	COG4187	Peptidase family M20/M25/M40
DL538_12295	COG1902	pentaerythritol trinitrate reductase activity
DL538_12300	COG0596	Alpha beta hydrolase
DL538_12310	COG1234	tRNA 3'-trailer cleavage
DL538_12315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DL538_12320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DL538_12325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DL538_12335	COG0706	membrane insertase activity
DL538_12340	COG3361	conserved protein (COG2071)
DL538_12345	COG2195	Cleaves the N-terminal amino acid of tripeptides
DL538_12350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DL538_12355	COG0346	lactoylglutathione lyase activity
DL538_12360	COG1376	ErfK ybiS ycfS ynhG family protein
DL538_12365	COG4129	membrane
DL538_12370	COG1126	abc transporter atp-binding protein
DL538_12375	COG0765	amino acid transport
DL538_12380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DL538_12390	COG1597	lipid kinase activity
DL538_12395	COG2814	Major facilitator Superfamily
DL538_12400	COG0789	Transcriptional regulator
DL538_12400	COG4978	Transcriptional regulator
DL538_12405	COG0508	dehydrogenase complex catalyzes the overall conversion of
DL538_12410	COG0022	dehydrogenase e1 component
DL538_12415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DL538_12420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DL538_12425	COG3426	butyrate kinase activity
DL538_12430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DL538_12435	COG0280	phosphate acetyltransferase
DL538_12440	COG3290	protein histidine kinase activity
DL538_12440	COG3829	transcription factor binding
DL538_12450	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DL538_12455	COG2079	MmgE PrpD family protein
DL538_12460	COG0372	Belongs to the citrate synthase family
DL538_12465	COG1960	acyl-CoA dehydrogenase activity
DL538_12470	COG1250	3-hydroxyacyl-CoA dehydrogenase
DL538_12475	COG0183	Belongs to the thiolase family
DL538_12480	COG0584	glycerophosphoryl diester phosphodiesterase
DL538_12485	COG0860	N-Acetylmuramoyl-L-alanine amidase
DL538_12495	COG1902	pentaerythritol trinitrate reductase activity
DL538_12500	COG0745	RESPONSE REGULATOR receiver
DL538_12510	COG0750	zinc metalloprotease
DL538_12515	COG0497	DNA recombination
DL538_12520	COG1438	arginine binding
DL538_12525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DL538_12530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DL538_12535	COG0142	geranyltranstransferase activity
DL538_12540	COG1722	exodeoxyribonuclease VII activity
DL538_12545	COG1570	exodeoxyribonuclease VII activity
DL538_12550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DL538_12555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DL538_12560	COG1302	Protein conserved in bacteria
DL538_12565	COG0439	Biotin carboxylase
DL538_12570	COG0511	ligase activity, forming carbon-carbon bonds
DL538_12610	COG3854	ATPases associated with a variety of cellular activities
DL538_12620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DL538_12625	COG0006	proline dipeptidase activity
DL538_12630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DL538_12640	COG3872	metal-dependent enzyme
DL538_12650	COG1752	Esterase of the alpha-beta hydrolase superfamily
DL538_12655	COG1321	iron dependent repressor
DL538_12660	COG0095	Lipoate-protein ligase
DL538_12665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DL538_12670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DL538_12675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DL538_12680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DL538_12685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DL538_12700	COG1396	sequence-specific DNA binding
DL538_12710	COG0681	Belongs to the peptidase S26 family
DL538_12735	COG4940	Competence protein ComGF
DL538_12745	COG4970	Tfp pilus assembly protein FimT
DL538_12750	COG4537	Required for transformation and DNA binding
DL538_12755	COG1459	type II secretion system
DL538_12760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DL538_12765	COG0517	IMP dehydrogenase activity
DL538_12770	COG0598	Magnesium transport protein CorA
DL538_12775	COG1253	flavin adenine dinucleotide binding
DL538_12780	COG1366	Belongs to the anti-sigma-factor antagonist family
DL538_12790	COG1393	Belongs to the ArsC family
DL538_12800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DL538_12810	COG0011	TIGRFAM Protein of
DL538_12820	COG2866	Carboxypeptidase
DL538_12825	COG1368	sulfuric ester hydrolase activity
DL538_12830	COG1940	carbohydrate kinase activity
DL538_12835	COG4483	Protein conserved in bacteria
DL538_12840	COG0457	Tetratricopeptide repeat
DL538_12840	COG0705	Rhomboid family
DL538_12850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DL538_12855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DL538_12860	COG0438	transferase activity, transferring glycosyl groups
DL538_12875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DL538_12880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DL538_12885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DL538_12890	COG0581	inorganic phosphate transmembrane transporter activity
DL538_12895	COG0573	inorganic phosphate transmembrane transporter activity
DL538_12900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DL538_12910	COG0477	Major facilitator Superfamily
DL538_12915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DL538_12920	COG2839	Protein conserved in bacteria
DL538_12925	COG5521	maltodextrose utilization protein MalA
DL538_12930	COG1388	LysM domain
DL538_12935	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DL538_12940	COG4709	membrane
DL538_12945	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DL538_12950	COG0735	belongs to the Fur family
DL538_12955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DL538_12965	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DL538_12970	COG0513	Belongs to the DEAD box helicase family
DL538_12980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DL538_12985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DL538_12990	COG2384	SAM-dependent methyltransferase
DL538_12995	COG2010	Cytochrome c
DL538_13005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DL538_13010	COG0358	DNA primase activity
DL538_13015	COG1671	Belongs to the UPF0178 family
DL538_13020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DL538_13025	COG0517	IMP dehydrogenase activity
DL538_13030	COG0751	glycine-tRNA ligase activity
DL538_13035	COG0752	glycyl-tRNA synthetase alpha subunit
DL538_13040	COG1381	Involved in DNA repair and RecF pathway recombination
DL538_13050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DL538_13055	COG0295	cytidine deaminase activity
DL538_13060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DL538_13065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DL538_13070	COG1480	7TM receptor with intracellular HD hydrolase
DL538_13075	COG1702	phosphate starvation-inducible protein PhoH
DL538_13080	COG0561	phosphatase activity
DL538_13095	COG4864	UPF0365 protein
DL538_13100	COG1030	water channel activity
DL538_13105	COG1610	YqeY-like protein
DL538_13110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DL538_13115	COG1283	sodium-dependent phosphate transmembrane transporter activity
DL538_13120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DL538_13125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DL538_13130	COG2264	protein methyltransferase activity
DL538_13135	COG0484	heat shock protein binding
DL538_13140	COG0443	Heat shock 70 kDa protein
DL538_13145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DL538_13150	COG1420	regulation of RNA biosynthetic process
DL538_13155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DL538_13160	COG0481	GTPase activity
DL538_13170	COG0860	N-Acetylmuramoyl-L-alanine amidase
DL538_13175	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DL538_13180	COG0268	Binds directly to 16S ribosomal RNA
DL538_13185	COG1466	dna polymerase III delta subunit
DL538_13195	COG2333	competence protein COMEC
DL538_13195	COG0658	competence protein
DL538_13200	COG2131	deaminase
DL538_13205	COG1596	polysaccharide export
DL538_13205	COG1555	photosystem II stabilization
DL538_13210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DL538_13215	COG2226	methyltransferase
DL538_13220	COG0799	negative regulation of ribosome biogenesis
DL538_13225	COG1713	HD superfamily hydrolase involved in NAD metabolism
DL538_13230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DL538_13235	COG1534	Rna-binding protein
DL538_13240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DL538_13245	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DL538_13250	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DL538_13260	COG2755	lipolytic protein G-D-S-L family
DL538_13265	COG3409	Peptidoglycan-binding domain 1 protein
DL538_13265	COG5632	N-Acetylmuramoyl-L-alanine amidase
DL538_13270	COG0398	Pfam SNARE associated Golgi protein
DL538_13275	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DL538_13285	COG3209	COG3209 Rhs family protein
DL538_13310	COG0604	alcohol dehydrogenase
DL538_13320	COG0457	Tetratricopeptide repeat
DL538_13335	COG5444	nuclease activity
DL538_13345	COG4282	regulation of fungal-type cell wall biogenesis
DL538_13360	COG1388	LysM domain
DL538_13360	COG3409	Peptidoglycan-binding domain 1 protein
DL538_13360	COG5632	N-Acetylmuramoyl-L-alanine amidase
DL538_13445	COG0563	adenylate kinase activity
DL538_13450	COG2856	Zn peptidase
DL538_13470	COG3223	Belongs to the PsiE family
DL538_13475	COG5002	protein histidine kinase activity
DL538_13475	COG0642	Histidine kinase
DL538_13480	COG0745	RESPONSE REGULATOR receiver
DL538_13485	COG2311	Membrane
DL538_13490	COG0454	-acetyltransferase
DL538_13495	COG2249	NAD(P)H dehydrogenase (quinone) activity
DL538_13505	COG0730	response to heat
DL538_13510	COG0425	Belongs to the sulfur carrier protein TusA family
DL538_13515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DL538_13515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DL538_13525	COG0425	Belongs to the sulfur carrier protein TusA family
DL538_13525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DL538_13530	COG2210	Belongs to the sulfur carrier protein TusA family
DL538_13535	COG1937	Protein conserved in bacteria
DL538_13550	COG0662	Cupin 2, conserved barrel domain protein
DL538_13570	COG4978	Transcriptional regulator
DL538_13570	COG0789	Transcriptional regulator
DL538_13575	COG2814	Major facilitator Superfamily
DL538_13580	COG0456	acetyltransferase
DL538_13585	COG1253	flavin adenine dinucleotide binding
DL538_13595	COG0697	spore germination
DL538_13600	COG0583	DNA-binding transcription factor activity
DL538_13605	COG2072	flavoprotein involved in K transport
DL538_13610	COG1230	cation diffusion facilitator family transporter
DL538_13615	COG1942	4-Oxalocrotonate Tautomerase
DL538_13620	COG0583	DNA-binding transcription factor activity
DL538_13630	COG1114	Component of the transport system for branched-chain amino acids
DL538_13635	COG1687	branched-chain amino acid
DL538_13640	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DL538_13645	COG1522	sequence-specific DNA binding
DL538_13655	COG2124	cytochrome p450
DL538_13660	COG1335	isochorismatase
DL538_13675	COG2318	DinB family
DL538_13685	COG2070	2-Nitropropane dioxygenase
DL538_13695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DL538_13710	COG3443	Belongs to the bacterial solute-binding protein 9 family
DL538_13715	COG1595	DNA-templated transcription, initiation
DL538_13720	COG0667	Aldo Keto reductase
DL538_13725	COG2851	Citrate transporter
DL538_13730	COG0583	DNA-binding transcription factor activity
DL538_13735	COG2828	Protein conserved in bacteria
DL538_13740	COG3409	Peptidoglycan-binding domain 1 protein
DL538_13745	COG5566	PFAM Mor transcription activator
DL538_13750	COG0596	Alpha beta hydrolase
DL538_13755	COG4991	sh3 domain protein
DL538_13760	COG4991	sh3 domain protein
DL538_13765	COG0346	lactoylglutathione lyase activity
DL538_13775	COG5577	PFAM Coat F domain
DL538_13780	COG1063	alcohol dehydrogenase
DL538_13790	COG5577	PFAM Coat F domain
DL538_13795	COG0789	Transcriptional regulator
DL538_13805	COG1064	alcohol dehydrogenase
DL538_13810	COG0693	protein deglycase activity
DL538_13815	COG1621	beta-fructofuranosidase activity
DL538_13820	COG3716	PTS system mannose fructose sorbose family IID component
DL538_13825	COG3715	PTS system
DL538_13830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_13835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DL538_13840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DL538_13840	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DL538_13845	COG1113	amino acid transport
DL538_13850	COG1280	lysine exporter protein (LysE YggA)
DL538_13855	COG1378	Sugar-specific transcriptional regulator TrmB
DL538_13860	COG1595	DNA-templated transcription, initiation
DL538_13870	COG2755	lipolytic protein G-D-S-L family
DL538_13870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DL538_13880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DL538_13880	COG2124	cytochrome p450
DL538_13885	COG1309	transcriptional regulator
DL538_13890	COG2226	methyltransferase
DL538_13900	COG2116	formate transmembrane transporter activity
DL538_13905	COG5609	conserved protein (DUF2294)
DL538_13910	COG3383	formate dehydrogenase (NAD+) activity
DL538_13915	COG2427	Protein of unknown function (DUF1641)
DL538_13925	COG0626	cystathionine gamma-synthase activity
DL538_13930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DL538_13935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DL538_13940	COG2226	methyltransferase
DL538_13955	COG0768	penicillin binding
DL538_13960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DL538_13965	COG0572	uridine kinase
DL538_13985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DL538_13990	COG3906	Belongs to the UPF0473 family
DL538_13995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DL538_14000	COG4472	Bacterial protein of unknown function (DUF965)
DL538_14005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DL538_14010	COG0628	permease
DL538_14015	COG1126	abc transporter atp-binding protein
DL538_14020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DL538_14025	COG0765	amino acid transport
DL538_14030	COG0765	amino acid transport
DL538_14045	COG3881	PFAM PRC-barrel domain
DL538_14050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DL538_14055	COG0457	Tetratricopeptide repeat
DL538_14060	COG0482	sulfurtransferase activity
DL538_14065	COG1104	cysteine desulfurase activity
DL538_14070	COG1959	2 iron, 2 sulfur cluster binding
DL538_14075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DL538_14080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DL538_14090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DL538_14095	COG0124	histidyl-tRNA synthetase
DL538_14105	COG4991	sh3 domain protein
DL538_14105	COG3103	Sh3 type 3 domain protein
DL538_14105	COG0860	N-Acetylmuramoyl-L-alanine amidase
DL538_14110	COG1490	D-aminoacyl-tRNA deacylase activity
DL538_14115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DL538_14120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DL538_14125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DL538_14125	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DL538_14130	COG5416	Lipopolysaccharide assembly protein A domain
DL538_14135	COG0490	domain, Protein
DL538_14140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DL538_14140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DL538_14150	COG2244	polysaccharide biosynthetic process
DL538_14155	COG2323	membrane
DL538_14165	COG1862	Preprotein translocase
DL538_14170	COG0343	queuine tRNA-ribosyltransferase activity
DL538_14175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DL538_14185	COG2255	four-way junction helicase activity
DL538_14190	COG0632	four-way junction helicase activity
DL538_14200	COG2814	Major facilitator Superfamily
DL538_14205	COG0673	inositol 2-dehydrogenase activity
DL538_14210	COG2112	serine threonine protein kinase
DL538_14225	COG1115	amino acid carrier protein
DL538_14230	COG0217	transcriptional regulatory protein
DL538_14240	COG1388	LysM domain
DL538_14245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DL538_14250	COG0157	Belongs to the NadC ModD family
DL538_14255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DL538_14260	COG1104	cysteine desulfurase activity
DL538_14265	COG1827	regulation of RNA biosynthetic process
DL538_14270	COG0077	Prephenate dehydratase
DL538_14275	COG4492	Belongs to the UPF0735 family
DL538_14280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DL538_14285	COG3290	protein histidine kinase activity
DL538_14290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DL538_14295	COG2868	ribosomal protein
DL538_14300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DL538_14305	COG1994	Peptidase M50
DL538_14310	COG0739	heme binding
DL538_14315	COG2894	cell division
DL538_14320	COG0850	regulation of cytokinetic process
DL538_14325	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DL538_14330	COG1792	Involved in formation and maintenance of cell shape
DL538_14335	COG1077	Cell shape determining protein MreB Mrl
DL538_14365	COG0457	Tetratricopeptide repeat
DL538_14370	COG5444	nuclease activity
DL538_14380	COG5632	N-Acetylmuramoyl-L-alanine amidase
DL538_14380	COG1388	LysM domain
DL538_14380	COG3409	Peptidoglycan-binding domain 1 protein
DL538_14385	COG4824	toxin secretion phage lysis holin
DL538_14420	COG1705	Flagellar rod assembly protein muramidase FlgJ
DL538_14430	COG3953	SLT domain
DL538_14430	COG5280	Phage tail tape measure protein TP901
DL538_14525	COG1598	PFAM Uncharacterised protein family UPF0150
DL538_14585	COG1396	sequence-specific DNA binding
DL538_14600	COG2003	Belongs to the UPF0758 family
DL538_14605	COG0424	maF-like protein
DL538_14615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DL538_14620	COG0285	dihydrofolate synthase activity
DL538_14625	COG0525	valine-tRNA ligase activity
DL538_14635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DL538_14640	COG1388	LysM domain
DL538_14645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DL538_14650	COG0113	porphobilinogen synthase activity
DL538_14655	COG1587	Uroporphyrinogen-III synthase
DL538_14660	COG0181	hydroxymethylbilane synthase activity
DL538_14665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DL538_14670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DL538_14680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DL538_14685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DL538_14690	COG0470	DNA polymerase III
DL538_14690	COG1067	ATP-dependent peptidase activity
DL538_14695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DL538_14700	COG0544	peptidyl-prolyl cis-trans isomerase activity
DL538_14705	COG0457	Tetratricopeptide repeat
DL538_14705	COG1477	protein flavinylation
DL538_14710	COG0066	3-isopropylmalate dehydratase activity
DL538_14715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DL538_14720	COG0473	3-isopropylmalate dehydrogenase activity
DL538_14725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DL538_14730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DL538_14735	COG0440	acetolactate synthase activity
DL538_14740	COG0028	Belongs to the TPP enzyme family
DL538_14750	COG0454	-acetyltransferase
DL538_14755	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
DL538_14765	COG0622	Phosphoesterase
DL538_14770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DL538_14775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DL538_14780	COG5401	PFAM Sporulation and spore germination
DL538_14785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DL538_14790	COG1846	Transcriptional regulator
DL538_14795	COG2197	response regulator
DL538_14800	COG0824	Thioesterase
DL538_14805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DL538_14810	COG1053	succinate dehydrogenase
DL538_14815	COG2009	succinate dehydrogenase
DL538_14820	COG1719	4-vinyl reductase, 4VR
DL538_14825	COG0527	aspartate kinase activity
DL538_14835	COG0322	excinuclease ABC activity
DL538_14840	COG3118	belongs to the thioredoxin family
DL538_14850	COG3534	alpha-L-arabinofuranosidase
DL538_14855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DL538_14860	COG2086	electron transfer activity
DL538_14865	COG1024	Enoyl-CoA hydratase
DL538_14870	COG1309	transcriptional regulator
DL538_14875	COG0318	PFAM AMP-dependent synthetase and ligase
DL538_14880	COG3766	membrane
DL538_14885	COG1193	negative regulation of DNA recombination
DL538_14890	COG1796	DNA polymerase
DL538_14890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DL538_14895	COG1286	toxin biosynthetic process
DL538_14900	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DL538_14905	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DL538_14910	COG0072	phenylalanine-tRNA ligase activity
DL538_14910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DL538_14915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DL538_14925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DL538_14935	COG3835	regulator
DL538_14940	COG0277	FAD linked oxidase domain protein
DL538_14945	COG0247	lactate metabolic process
DL538_14950	COG0346	lactoylglutathione lyase activity
DL538_14960	COG1966	Carbon starvation protein
DL538_14965	COG3534	alpha-L-arabinofuranosidase
DL538_14970	COG0395	ABC-type sugar transport system, permease component
DL538_14975	COG1175	transmembrane transport
DL538_14980	COG1653	transport
DL538_14985	COG0371	Dehydrogenase
DL538_14990	COG0647	UMP catabolic process
DL538_14995	COG0235	Class ii aldolase
DL538_15000	COG1069	ribulokinase activity
DL538_15005	COG2160	L-arabinose isomerase activity
DL538_15010	COG3507	Belongs to the glycosyl hydrolase 43 family
DL538_15015	COG1363	Peptidase, m42
DL538_15025	COG3326	Membrane
DL538_15030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DL538_15035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DL538_15040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DL538_15050	COG1346	cytolysis
DL538_15055	COG1380	Effector of murein hydrolase LrgA
DL538_15060	COG3279	Response regulator of the LytR AlgR family
DL538_15065	COG3275	phosphorelay sensor kinase activity
DL538_15075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DL538_15085	COG0398	Pfam SNARE associated Golgi protein
DL538_15090	COG1484	DNA-dependent DNA replication
DL538_15095	COG3611	Membrane attachment protein
DL538_15100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DL538_15105	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DL538_15110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DL538_15115	COG1733	regulation of RNA biosynthetic process
DL538_15120	COG2814	Major facilitator Superfamily
DL538_15125	COG0656	L-ascorbic acid biosynthetic process
DL538_15130	COG0237	dephospho-CoA kinase activity
DL538_15135	COG1971	Probably functions as a manganese efflux pump
DL538_15140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DL538_15145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DL538_15145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DL538_15150	COG5002	protein histidine kinase activity
DL538_15155	COG0745	RESPONSE REGULATOR receiver
DL538_15165	COG0039	L-malate dehydrogenase activity
DL538_15170	COG0538	isocitrate dehydrogenase activity
DL538_15175	COG0372	Belongs to the citrate synthase family
DL538_15180	COG2707	UPF0756 membrane protein
DL538_15185	COG0628	permease
DL538_15190	COG3030	protein affecting phage T7 exclusion by the F plasmid
DL538_15195	COG0469	pyruvate kinase activity
DL538_15200	COG0205	6-phosphofructokinase activity
DL538_15205	COG0825	malonyl-CoA metabolic process
DL538_15210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DL538_15215	COG0281	malic enzyme
DL538_15220	COG0587	DNA-directed DNA polymerase activity
DL538_15240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DL538_15250	COG4109	DRTGG domain
DL538_15255	COG0730	response to heat
DL538_15260	COG1473	amidohydrolase
DL538_15265	COG0196	riboflavin kinase activity
DL538_15270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DL538_15275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DL538_15280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DL538_15285	COG1126	abc transporter atp-binding protein
DL538_15290	COG0765	amino acid transport
DL538_15295	COG0765	amino acid transport
DL538_15300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DL538_15305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DL538_15310	COG0454	-acetyltransferase
DL538_15315	COG0583	DNA-binding transcription factor activity
DL538_15320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DL538_15325	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_15335	COG0165	Argininosuccinate lyase
DL538_15340	COG0137	argininosuccinate synthase activity
DL538_15345	COG0521	Mo-molybdopterin cofactor biosynthetic process
DL538_15350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DL538_15360	COG0827	DNA restriction-modification system
DL538_15365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DL538_15370	COG3874	Sporulation protein YtfJ
DL538_15380	COG1714	RDD family
DL538_15385	COG0616	signal peptide processing
DL538_15390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DL538_15395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DL538_15400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DL538_15410	COG0301	tRNA thio-modification
DL538_15415	COG1104	cysteine desulfurase activity
DL538_15420	COG1114	Component of the transport system for branched-chain amino acids
DL538_15425	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DL538_15430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DL538_15435	COG1309	transcriptional regulator
DL538_15440	COG1956	GAF domain-containing protein
DL538_15445	COG2199	diguanylate cyclase activity
DL538_15445	COG2203	Gaf domain
DL538_15455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DL538_15460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DL538_15470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DL538_15475	COG0454	-acetyltransferase
DL538_15480	COG0517	IMP dehydrogenase activity
DL538_15485	COG0123	including yeast histone deacetylase and acetoin utilization protein
DL538_15490	COG1360	Flagellar Motor Protein
DL538_15495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DL538_15500	COG1609	Transcriptional regulator
DL538_15505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DL538_15505	COG1605	Chorismate mutase
DL538_15510	COG3118	belongs to the thioredoxin family
DL538_15515	COG4980	gas vesicle protein
DL538_15520	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DL538_15525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DL538_15530	COG1674	ftsk spoiiie
DL538_15535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DL538_15540	COG4848	Belongs to the UPF0354 family
DL538_15545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_15555	COG1363	Peptidase, m42
DL538_15560	COG5584	Small secreted protein
DL538_15565	COG0281	malic enzyme
DL538_15570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DL538_15575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DL538_15585	COG0510	thiamine kinase activity
DL538_15590	COG1523	belongs to the glycosyl hydrolase 13 family
DL538_15595	COG1597	lipid kinase activity
DL538_15605	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DL538_15610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DL538_15615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DL538_15620	COG2252	PERMEase
DL538_15625	COG4473	ABC transporter
DL538_15630	COG1131	(ABC) transporter
DL538_15635	COG1349	DNA-binding transcription factor activity
DL538_15640	COG1187	pseudouridine synthase activity
DL538_15645	COG2244	polysaccharide biosynthetic process
DL538_15650	COG2081	HI0933 family
DL538_15655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DL538_15665	COG5578	integral membrane protein
DL538_15670	COG0673	inositol 2-dehydrogenase activity
DL538_15675	COG1653	transport
DL538_15680	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DL538_15685	COG4209	transmembrane transport
DL538_15690	COG2207	Transcriptional regulator
DL538_15695	COG1653	transport
DL538_15700	COG0395	ABC-type sugar transport system, permease component
DL538_15705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DL538_15710	COG2124	cytochrome p450
DL538_15715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DL538_15725	COG0156	8-amino-7-oxononanoate synthase activity
DL538_15730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DL538_15740	COG1073	alpha beta
DL538_15765	COG1486	melibiose metabolic process
DL538_15770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DL538_15775	COG0495	leucyl-tRNA aminoacylation
DL538_15785	COG2202	Pas domain
DL538_15785	COG1366	Belongs to the anti-sigma-factor antagonist family
DL538_15790	COG2814	Major facilitator Superfamily
DL538_15795	COG2433	Pfam Transposase IS66
DL538_15800	COG0577	efflux transmembrane transporter activity
DL538_15805	COG1136	(ABC) transporter
DL538_15810	COG2205	protein histidine kinase activity
DL538_15815	COG0745	RESPONSE REGULATOR receiver
DL538_15820	COG0577	efflux transmembrane transporter activity
DL538_15825	COG1136	(ABC) transporter
DL538_15840	COG1131	(ABC) transporter
DL538_15845	COG1725	Transcriptional regulator
DL538_15855	COG1242	4 iron, 4 sulfur cluster binding
DL538_15860	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DL538_15870	COG2267	carboxylic ester hydrolase activity
DL538_15875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DL538_15880	COG1113	amino acid transport
DL538_15885	COG0367	asparagine synthase
DL538_15890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DL538_15895	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DL538_15905	COG1506	peptidase
DL538_15910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DL538_15915	COG1116	anion transmembrane transporter activity
DL538_15920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DL538_15925	COG0494	nUDIX hydrolase
DL538_15930	COG4824	toxin secretion phage lysis holin
DL538_15935	COG0783	Belongs to the Dps family
DL538_15950	COG1854	S-ribosylhomocysteine lyase activity
DL538_15955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DL538_15960	COG0288	reversible hydration of carbon dioxide
DL538_15965	COG0254	rRNA binding
DL538_15970	COG1271	oxidase subunit
DL538_15975	COG1294	oxidase, subunit
DL538_15985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DL538_15990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DL538_15990	COG1321	iron dependent repressor
DL538_15995	COG1121	(ABC) transporter
DL538_16000	COG0803	Belongs to the bacterial solute-binding protein 9 family
DL538_16010	COG4948	Mandelate Racemase Muconate Lactonizing
DL538_16015	COG0318	PFAM AMP-dependent synthetase and ligase
DL538_16020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DL538_16025	COG0596	Alpha beta hydrolase
DL538_16030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DL538_16035	COG1169	isochorismate synthase
DL538_16040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DL538_16045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DL538_16050	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DL538_16055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DL538_16060	COG0438	transferase activity, transferring glycosyl groups
DL538_16070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DL538_16075	COG0438	transferase activity, transferring glycosyl groups
DL538_16080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DL538_16090	COG0058	SHG alpha-glucan phosphorylase activity
DL538_16095	COG0297	glycogen (starch) synthase activity
DL538_16100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DL538_16105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DL538_16110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DL538_16235	COG3859	Proton-coupled thiamine transporter YuaJ
DL538_16240	COG1247	-acetyltransferase
DL538_16245	COG2268	Band 7 protein
DL538_16250	COG1585	Membrane protein implicated in regulation of membrane protease activity
DL538_16255	COG2318	DinB family
DL538_16265	COG1454	alcohol dehydrogenase
DL538_16275	COG1510	regulation of RNA biosynthetic process
DL538_16285	COG0569	domain protein
DL538_16290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DL538_16295	COG4682	membrane
DL538_16300	COG1705	Flagellar rod assembly protein muramidase FlgJ
DL538_16305	COG0477	Major facilitator Superfamily
DL538_16310	COG5553	Cysteine dioxygenase type I
DL538_16345	COG5632	N-Acetylmuramoyl-L-alanine amidase
DL538_16345	COG3409	Peptidoglycan-binding domain 1 protein
DL538_16475	COG1783	phage Terminase large subunit
DL538_16480	COG5484	DNA packaging
DL538_16490	COG3677	Transposase
DL538_16575	COG1484	DNA-dependent DNA replication
DL538_16580	COG3935	DnaD domain protein
DL538_16585	COG3723	Recombinational DNA repair protein, rece pathway
DL538_16590	COG5377	YqaJ viral recombinase family
DL538_16640	COG1396	sequence-specific DNA binding
DL538_16650	COG2856	Zn peptidase
DL538_16655	COG0582	viral genome integration into host DNA
DL538_16665	COG1968	undecaprenyl-diphosphatase activity
DL538_16670	COG0628	permease
DL538_16675	COG0673	inositol 2-dehydrogenase activity
DL538_16680	COG4806	L-rhamnose isomerase
DL538_16685	COG3254	rhamnose metabolic process
DL538_16690	COG1070	Carbohydrate kinase
DL538_16695	COG1349	DNA-binding transcription factor activity
DL538_16700	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_16700	COG3347	Dehydrogenase
DL538_16710	COG0840	transmembrane signaling receptor activity
DL538_16715	COG0840	transmembrane signaling receptor activity
DL538_16720	COG0840	transmembrane signaling receptor activity
DL538_16725	COG0840	transmembrane signaling receptor activity
DL538_16740	COG0432	Pfam Uncharacterised protein family UPF0047
DL538_16745	COG0366	Alpha amylase catalytic
DL538_16750	COG1253	flavin adenine dinucleotide binding
DL538_16755	COG2738	Putative neutral zinc metallopeptidase
DL538_16770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DL538_16785	COG0166	Belongs to the GPI family
DL538_16790	COG1979	alcohol dehydrogenase
DL538_16795	COG1979	alcohol dehydrogenase
DL538_16800	COG2155	Conserved Protein
DL538_16805	COG1098	S1 RNA binding domain
DL538_16810	COG0436	Aminotransferase
DL538_16815	COG1522	sequence-specific DNA binding
DL538_16820	COG2267	carboxylic ester hydrolase activity
DL538_16830	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DL538_16835	COG2205	protein histidine kinase activity
DL538_16845	COG5018	Exonuclease
DL538_16855	COG2814	Major facilitator Superfamily
DL538_16860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DL538_16865	COG3011	Protein conserved in bacteria
DL538_16875	COG3290	protein histidine kinase activity
DL538_16880	COG4565	transcriptional regulatory protein
DL538_16905	COG3493	citrate carrier protein
DL538_16915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DL538_16915	COG2111	Na H antiporter
DL538_16920	COG2111	Na H antiporter
DL538_16925	COG1006	Multisubunit Na H antiporter MnhC subunit
DL538_16930	COG0651	ATP synthesis coupled electron transport
DL538_16935	COG1863	multisubunit Na H antiporter MnhE subunit
DL538_16940	COG2212	antiporter activity
DL538_16945	COG1320	monovalent cation:proton antiporter activity
DL538_16950	COG2050	protein possibly involved in aromatic compounds catabolism
DL538_16955	COG2197	response regulator
DL538_16960	COG4585	Histidine kinase
DL538_16970	COG0142	geranyltranstransferase activity
DL538_16985	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DL538_16990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DL538_16995	COG1335	isochorismatase
DL538_17000	COG5506	Protein of unknown function (DUF1694)
DL538_17015	COG0628	permease
DL538_17030	COG1418	mRNA catabolic process
DL538_17035	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_17045	COG1511	domain protein
DL538_17050	COG1674	ftsk spoiiie
DL538_17050	COG0433	COG0433 Predicted ATPase
DL538_17055	COG4499	WXG100 protein secretion system (Wss), protein YukC
DL538_17060	COG5417	Belongs to the EsaB family
DL538_17065	COG4842	Belongs to the WXG100 family
DL538_17070	COG2508	Transcriptional regulator
DL538_17070	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DL538_17075	COG0686	Belongs to the AlaDH PNT family
DL538_17080	COG5634	Uncharacterized conserved protein (DUF2278)
DL538_17085	COG3251	PFAM MbtH domain protein
DL538_17090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_17095	COG1535	isochorismatase
DL538_17095	COG3433	isochorismatase activity
DL538_17100	COG1021	2,3-dihydroxybenzoate-AMP ligase
DL538_17105	COG1169	isochorismate synthase
DL538_17110	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_17115	COG2819	hydrolase of the alpha beta superfamily
DL538_17120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DL538_17125	COG1268	BioY protein
DL538_17130	COG2056	Na+-H+ antiporter family
DL538_17135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DL538_17140	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DL538_17145	COG3584	3D domain protein
DL538_17160	COG1252	NADH dehydrogenase
DL538_17165	COG0492	ferredoxin-NADP+ reductase activity
DL538_17175	COG0516	GMP reductase activity
DL538_17180	COG2808	Putative FMN-binding domain
DL538_17185	COG0456	acetyltransferase
DL538_17190	COG0316	Belongs to the HesB IscA family
DL538_17195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DL538_17200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DL538_17205	COG4844	belongs to the
DL538_17210	COG1252	NADH dehydrogenase
DL538_17215	COG4837	Protein of unknown function (DUF1462)
DL538_17220	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DL538_17225	COG4946	Tricorn protease homolog
DL538_17225	COG1506	peptidase
DL538_17225	COG0823	Involved in the tonB-independent uptake of proteins
DL538_17230	COG0083	homoserine kinase activity
DL538_17235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DL538_17240	COG0460	homoserine dehydrogenase
DL538_17245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DL538_17250	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DL538_17255	COG0647	UMP catabolic process
DL538_17260	COG2445	Protein of unknown function DUF86
DL538_17265	COG4470	Protein conserved in bacteria
DL538_17275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DL538_17280	COG0739	heme binding
DL538_17290	COG3377	Domain of unknown function (DUF1805)
DL538_17295	COG0737	Belongs to the 5'-nucleotidase family
DL538_17300	COG0730	response to heat
DL538_17305	COG1801	Protein of unknown function DUF72
DL538_17315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DL538_17320	COG2508	Transcriptional regulator
DL538_17325	COG2233	PERMEase
DL538_17330	COG2233	PERMEase
DL538_17335	COG3195	allantoin biosynthetic process
DL538_17335	COG3648	Uricase
DL538_17340	COG2351	hydroxyisourate hydrolase activity
DL538_17350	COG2080	2 iron, 2 sulfur cluster binding
DL538_17355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DL538_17360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DL538_17365	COG2068	MobA-Related Protein
DL538_17370	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DL538_17375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DL538_17380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DL538_17385	COG2356	endonuclease I
DL538_17390	COG3842	ATPase activity
DL538_17395	COG2188	Transcriptional regulator
DL538_17400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DL538_17405	COG0395	ABC-type sugar transport system, permease component
DL538_17410	COG1175	transmembrane transport
DL538_17415	COG1653	transport
DL538_17420	COG2222	sugar isomerase
DL538_17425	COG0322	excinuclease ABC activity
DL538_17430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DL538_17445	COG0346	lactoylglutathione lyase activity
DL538_17450	COG0640	Transcriptional regulator
DL538_17455	COG0719	Fe-S assembly protein
DL538_17460	COG0822	iron-sulfur transferase activity
DL538_17465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DL538_17470	COG0719	Fe-S assembly protein
DL538_17475	COG0396	ATPase activity
DL538_17490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DL538_17495	COG1464	Belongs to the NlpA lipoprotein family
DL538_17500	COG2011	ABC-type metal ion transport system permease component
DL538_17505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DL538_17515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DL538_17520	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DL538_17530	COG0509	glycine decarboxylation via glycine cleavage system
DL538_17535	COG1393	Belongs to the ArsC family
DL538_17540	COG1960	acyl-CoA dehydrogenase activity
DL538_17545	COG0183	Belongs to the thiolase family
DL538_17550	COG1024	Enoyl-CoA hydratase
DL538_17550	COG1250	3-hydroxyacyl-CoA dehydrogenase
DL538_17560	COG0506	proline dehydrogenase activity
DL538_17570	COG5577	PFAM Coat F domain
DL538_17575	COG1846	Transcriptional regulator
DL538_17580	COG0477	Major facilitator Superfamily
DL538_17585	COG1942	4-Oxalocrotonate Tautomerase
DL538_17590	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_17595	COG0583	DNA-binding transcription factor activity
DL538_17605	COG1120	ATPase activity
DL538_17620	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_17625	COG0783	Belongs to the Dps family
DL538_17630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DL538_17635	COG0745	RESPONSE REGULATOR receiver
DL538_17640	COG2205	protein histidine kinase activity
DL538_17640	COG2770	Histidine kinase
DL538_17650	COG1309	transcriptional regulator
DL538_17655	COG0114	fumarate hydratase activity
DL538_17665	COG0697	spore germination
DL538_17670	COG0814	amino acid
DL538_17680	COG2197	response regulator
DL538_17685	COG4585	Histidine kinase
DL538_17690	COG4758	membrane
DL538_17695	COG3595	metallopeptidase activity
DL538_17700	COG1842	Phage shock protein A
DL538_17705	COG4758	membrane
DL538_17710	COG2814	Major facilitator Superfamily
DL538_17715	COG2096	Adenosyltransferase
DL538_17720	COG1120	ATPase activity
DL538_17725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_17730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DL538_17735	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_17740	COG3386	PFAM SMP-30 Gluconolaconase
DL538_17745	COG2205	protein histidine kinase activity
DL538_17750	COG0745	RESPONSE REGULATOR receiver
DL538_17760	COG1191	sigma factor activity
DL538_17770	COG2140	Oxalate decarboxylase
DL538_17780	COG0577	efflux transmembrane transporter activity
DL538_17785	COG1136	(ABC) transporter
DL538_17790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DL538_17795	COG1120	ATPase activity
DL538_17800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_17805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DL538_17810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DL538_17815	COG0531	amino acid
DL538_17830	COG1988	membrane-bound metal-dependent
DL538_17835	COG1368	sulfuric ester hydrolase activity
DL538_17840	COG1910	domain protein
DL538_17845	COG0725	ABC transporter, periplasmic molybdate-binding protein
DL538_17850	COG4149	molybdate abc transporter
DL538_17855	COG0656	L-ascorbic acid biosynthetic process
DL538_17865	COG0025	NhaP-type Na H and K H
DL538_17870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DL538_17875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DL538_17880	COG3973	AAA domain
DL538_17890	COG2860	membrane
DL538_17895	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DL538_17900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DL538_17905	COG2217	Heavy metal translocating P-type atpase
DL538_17910	COG2217	Heavy metal translocating P-type atpase
DL538_17915	COG2608	mercury ion transmembrane transporter activity
DL538_17920	COG1937	Protein conserved in bacteria
DL538_17925	COG0673	inositol 2-dehydrogenase activity
DL538_17930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DL538_17935	COG1289	transmembrane transporter activity
DL538_17945	COG2076	Multidrug Resistance protein
DL538_17950	COG1309	transcriptional regulator
DL538_17955	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_17965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DL538_17970	COG0557	exoribonuclease II activity
DL538_17975	COG1647	Serine aminopeptidase, S33
DL538_17980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DL538_17985	COG0596	Alpha beta hydrolase
DL538_17990	COG1476	TRANSCRIPTIONal
DL538_17995	COG1396	sequence-specific DNA binding
DL538_18000	COG1396	sequence-specific DNA binding
DL538_18005	COG1733	regulation of RNA biosynthetic process
DL538_18010	COG0840	transmembrane signaling receptor activity
DL538_18015	COG1174	glycine betaine transport
DL538_18020	COG1732	Glycine betaine
DL538_18025	COG1174	glycine betaine transport
DL538_18030	COG1125	glycine betaine transport
DL538_18030	COG0517	IMP dehydrogenase activity
DL538_18035	COG1510	regulation of RNA biosynthetic process
DL538_18040	COG1174	glycine betaine transport
DL538_18045	COG1732	Glycine betaine
DL538_18050	COG1174	glycine betaine transport
DL538_18055	COG1125	glycine betaine transport
DL538_18055	COG0517	IMP dehydrogenase activity
DL538_18060	COG1510	regulation of RNA biosynthetic process
DL538_18065	COG2095	MarC family integral membrane protein
DL538_18075	COG3064	Membrane
DL538_18080	COG4640	response to antibiotic
DL538_18085	COG0456	acetyltransferase
DL538_18095	COG0148	phosphopyruvate hydratase activity
DL538_18100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DL538_18105	COG0149	triose-phosphate isomerase activity
DL538_18110	COG0126	phosphoglycerate kinase activity
DL538_18115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DL538_18120	COG2390	Transcriptional regulator
DL538_18125	COG2814	Major facilitator Superfamily
DL538_18130	COG1609	Transcriptional regulator
DL538_18135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DL538_18145	COG0583	DNA-binding transcription factor activity
DL538_18150	COG0697	spore germination
DL538_18155	COG1113	amino acid transport
DL538_18160	COG3858	chitin binding
DL538_18165	COG1556	Lactate utilization protein
DL538_18170	COG1139	Iron-sulfur cluster binding protein
DL538_18175	COG0247	lactate metabolic process
DL538_18180	COG2197	response regulator
DL538_18185	COG4585	Histidine kinase
DL538_18190	COG0842	Transport permease protein
DL538_18195	COG1131	(ABC) transporter
DL538_18200	COG0596	Alpha beta hydrolase
DL538_18205	COG2208	phosphoserine phosphatase activity
DL538_18210	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DL538_18215	COG1874	Beta-galactosidase
DL538_18220	COG3833	ABC-type maltose transport systems, permease component
DL538_18225	COG1175	transmembrane transport
DL538_18230	COG2182	Extracellular solute-binding protein
DL538_18235	COG1609	Transcriptional regulator
DL538_18240	COG2186	Transcriptional regulator
DL538_18245	COG1620	l-lactate permease
DL538_18250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DL538_18260	COG5039	Polysaccharide pyruvyl transferase
DL538_18265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DL538_18270	COG0110	maltose O-acetyltransferase activity
DL538_18275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DL538_18280	COG2244	polysaccharide biosynthetic process
DL538_18285	COG1216	Glycosyl transferase, family 2
DL538_18290	COG5039	Polysaccharide pyruvyl transferase
DL538_18295	COG1216	Glycosyl transferase, family 2
DL538_18305	COG0438	transferase activity, transferring glycosyl groups
DL538_18310	COG1215	transferase activity, transferring glycosyl groups
DL538_18315	COG0438	transferase activity, transferring glycosyl groups
DL538_18320	COG1086	Polysaccharide biosynthesis protein
DL538_18325	COG0489	protein tyrosine kinase activity
DL538_18330	COG3944	biosynthesis protein
DL538_18335	COG1396	sequence-specific DNA binding
DL538_18340	COG2272	Belongs to the type-B carboxylesterase lipase family
DL538_18350	COG3479	Phenolic acid decarboxylase
DL538_18360	COG1794	racemase activity, acting on amino acids and derivatives
DL538_18365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DL538_18370	COG1621	beta-fructofuranosidase activity
DL538_18375	COG1621	beta-fructofuranosidase activity
DL538_18380	COG0531	amino acid
DL538_18385	COG1309	transcriptional regulator
DL538_18390	COG2076	Multidrug Resistance protein
DL538_18395	COG2076	Multidrug Resistance protein
DL538_18405	COG0277	FAD linked oxidase domain protein
DL538_18410	COG3621	Patatin-like phospholipase
DL538_18420	COG0740	serine-type endopeptidase activity
DL538_18425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DL538_18430	COG0366	Alpha amylase catalytic
DL538_18435	COG1554	hydrolase, family 65, central catalytic
DL538_18440	COG5521	maltodextrose utilization protein MalA
DL538_18445	COG3833	ABC-type maltose transport systems, permease component
DL538_18450	COG1175	transmembrane transport
DL538_18455	COG2182	Extracellular solute-binding protein
DL538_18465	COG1609	Transcriptional regulator
DL538_18470	COG1611	Belongs to the LOG family
DL538_18475	COG1694	Mazg nucleotide pyrophosphohydrolase
DL538_18480	COG0659	secondary active sulfate transmembrane transporter activity
DL538_18485	COG0288	reversible hydration of carbon dioxide
DL538_18495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DL538_18500	COG0577	efflux transmembrane transporter activity
DL538_18505	COG1136	(ABC) transporter
DL538_18510	COG5002	protein histidine kinase activity
DL538_18515	COG0745	RESPONSE REGULATOR receiver
DL538_18525	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DL538_18530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DL538_18535	COG1481	regulation of sporulation
DL538_18540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DL538_18545	COG1660	Displays ATPase and GTPase activities
DL538_18550	COG1051	belongs to the nudix hydrolase family
DL538_18555	COG0492	ferredoxin-NADP+ reductase activity
DL538_18560	COG3883	PFAM NLP P60 protein
DL538_18560	COG0791	NLP P60 protein
DL538_18565	COG0457	Tetratricopeptide repeat
DL538_18570	COG1132	(ABC) transporter
DL538_18605	COG0140	phosphoribosyl-ATP diphosphatase activity
DL538_18605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DL538_18610	COG0107	imidazoleglycerol-phosphate synthase activity
DL538_18615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DL538_18620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DL538_18625	COG0131	Imidazoleglycerol-phosphate dehydratase
DL538_18630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DL538_18635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DL538_18640	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DL538_18645	COG4990	cell redox homeostasis
DL538_18650	COG5297	Belongs to the glycosyl hydrolase family 6
DL538_18655	COG0110	maltose O-acetyltransferase activity
DL538_18660	COG0546	phosphoglycolate phosphatase activity
DL538_18665	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DL538_18670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DL538_18675	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DL538_18680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DL538_18685	COG0363	glucosamine-6-phosphate deaminase activity
DL538_18695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DL538_18700	COG1846	Transcriptional regulator
DL538_18705	COG2124	cytochrome p450
DL538_18715	COG1846	Transcriptional regulator
DL538_18720	COG2814	Major facilitator Superfamily
DL538_18725	COG1950	PFAM Membrane protein of
DL538_18730	COG1983	PspC domain protein
DL538_18735	COG3595	metallopeptidase activity
DL538_18755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DL538_18760	COG0556	nucleotide-excision repair
DL538_18765	COG4897	Protein conserved in bacteria
DL538_18770	COG3848	Pyruvate phosphate dikinase
DL538_18770	COG0574	Belongs to the PEP-utilizing enzyme family
DL538_18775	COG1309	transcriptional regulator
DL538_18780	COG2814	Major facilitator Superfamily
DL538_18785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DL538_18795	COG0793	Belongs to the peptidase S41A family
DL538_18795	COG3409	Peptidoglycan-binding domain 1 protein
DL538_18800	COG2177	Part of the ABC transporter FtsEX involved in
DL538_18805	COG2884	Cell division ATP-binding protein ftsE
DL538_18810	COG2010	Cytochrome c
DL538_18815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DL538_18825	COG0653	protein targeting
DL538_18830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DL538_18845	COG1516	flagellar protein fliS
DL538_18850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DL538_18855	COG1334	flagellar protein FlaG
DL538_18860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DL538_18865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DL538_18870	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DL538_18880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DL538_18885	COG1256	bacterial-type flagellum assembly
DL538_18885	COG4786	Flagellar basal body rod
DL538_18890	COG3418	PFAM FlgN family protein
DL538_18895	COG2747	anti-sigma28 factor FlgM
DL538_18905	COG1040	competence protein
DL538_18920	COG1307	EDD domain protein, DegV family
DL538_18925	COG2197	response regulator
DL538_18930	COG4585	Histidine kinase
DL538_18935	COG1739	Uncharacterized protein family UPF0029
DL538_18940	COG1316	TRANSCRIPTIONal
DL538_18945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DL538_18950	COG0438	transferase activity, transferring glycosyl groups
DL538_18955	COG1215	transferase activity, transferring glycosyl groups
DL538_18960	COG3206	protein involved in exopolysaccharide biosynthesis
DL538_18965	COG3307	-O-antigen
DL538_18970	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DL538_18975	COG0438	transferase activity, transferring glycosyl groups
DL538_18975	COG0297	glycogen (starch) synthase activity
DL538_18980	COG2244	polysaccharide biosynthetic process
DL538_18995	COG2247	cell wall binding repeat
DL538_18995	COG0860	N-Acetylmuramoyl-L-alanine amidase
DL538_19000	COG2247	cell wall binding repeat
DL538_19000	COG2385	sporulation resulting in formation of a cellular spore
DL538_19010	COG1316	TRANSCRIPTIONal
DL538_19015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DL538_19035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DL538_19040	COG1134	teichoic acid transport
DL538_19045	COG1682	transport, permease protein
DL538_19050	COG1215	transferase activity, transferring glycosyl groups
DL538_19050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DL538_19055	COG0463	Glycosyl transferase, family 2
DL538_19100	COG4193	domain, Protein
DL538_19105	COG1482	cell wall glycoprotein biosynthetic process
DL538_19110	COG0697	spore germination
DL538_19115	COG0814	amino acid
DL538_19125	COG2814	Major facilitator Superfamily
DL538_19130	COG1316	TRANSCRIPTIONal
DL538_19135	COG0561	phosphatase activity
DL538_19140	COG0791	NLP P60 protein
DL538_19150	COG2843	Capsule synthesis protein
DL538_19160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DL538_19170	COG1609	Transcriptional regulator
DL538_19175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DL538_19180	COG1869	D-ribose catabolic process
DL538_19185	COG1129	ABC transporter
DL538_19190	COG1172	Belongs to the binding-protein-dependent transport system permease family
DL538_19195	COG1879	ABC-type sugar transport system periplasmic component
DL538_19200	COG3103	Sh3 type 3 domain protein
DL538_19210	COG2249	NAD(P)H dehydrogenase (quinone) activity
DL538_19215	COG3527	Alpha-acetolactate decarboxylase
DL538_19220	COG0028	Belongs to the TPP enzyme family
DL538_19225	COG0583	DNA-binding transcription factor activity
DL538_19230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DL538_19245	COG5337	Spore coat protein CotH
DL538_19255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DL538_19265	COG0405	Gamma-glutamyltransferase
DL538_19270	COG1522	sequence-specific DNA binding
DL538_19275	COG2059	Chromate
DL538_19280	COG2059	Chromate
DL538_19290	COG0655	NAD(P)H dehydrogenase (quinone) activity
DL538_19295	COG0583	DNA-binding transcription factor activity
DL538_19310	COG5444	nuclease activity
DL538_19330	COG3878	Protein conserved in bacteria
DL538_19335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DL538_19340	COG4464	protein tyrosine phosphatase activity
DL538_19345	COG0489	protein tyrosine kinase activity
DL538_19350	COG3944	biosynthesis protein
DL538_19360	COG4715	Zinc finger, swim domain protein
DL538_19365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DL538_19370	COG0561	phosphatase activity
DL538_19375	COG1349	DNA-binding transcription factor activity
DL538_19380	COG0629	single-stranded DNA binding
DL538_19395	COG3764	Sortase (surface protein transpeptidase)
DL538_19400	COG2972	Histidine kinase
DL538_19400	COG0745	RESPONSE REGULATOR receiver
DL538_19405	COG1970	mechanosensitive ion channel activity
DL538_19410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DL538_19415	COG0457	Tetratricopeptide repeat
DL538_19420	COG4786	Flagellar basal body rod
DL538_19425	COG4786	Flagellar basal body rod
DL538_19430	COG1077	Cell shape determining protein MreB Mrl
DL538_19435	COG1609	Transcriptional regulator
DL538_19445	COG1846	Transcriptional regulator
DL538_19450	COG2814	Major facilitator Superfamily
DL538_19455	COG3420	alginic acid biosynthetic process
DL538_19460	COG1953	Uracil, thiamine, allantoin
DL538_19465	COG0477	Major facilitator Superfamily
DL538_19470	COG1335	isochorismatase
DL538_19480	COG0004	ammonium transporteR
DL538_19485	COG0347	Belongs to the P(II) protein family
DL538_19490	COG0671	phosphoesterase, PA-phosphatase related
DL538_19500	COG0739	heme binding
DL538_19505	COG1247	-acetyltransferase
DL538_19520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DL538_19535	COG2910	NAD(P)H-binding
DL538_19540	COG1959	2 iron, 2 sulfur cluster binding
DL538_19545	COG0804	urea catabolic process
DL538_19550	COG0832	Belongs to the urease beta subunit family
DL538_19555	COG0831	urea catabolic process
DL538_19570	COG3237	CsbD-like
DL538_19575	COG1994	Peptidase M50
DL538_19580	COG0457	Tetratricopeptide repeat
DL538_19590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DL538_19595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DL538_19605	COG2304	oxidoreductase activity
DL538_19615	COG2304	oxidoreductase activity
DL538_19620	COG2385	sporulation resulting in formation of a cellular spore
DL538_19625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DL538_19635	COG4836	Membrane
DL538_19645	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DL538_19650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DL538_19655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DL538_19660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DL538_19665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DL538_19670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DL538_19675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DL538_19680	COG0356	it plays a direct role in the translocation of protons across the membrane
DL538_19690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DL538_19695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DL538_19700	COG4475	Protein of unknown function (DUF436)
DL538_19705	COG0698	ribose 5-phosphate isomerase
DL538_19710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DL538_19715	COG1971	Probably functions as a manganese efflux pump
DL538_19720	COG0009	L-threonylcarbamoyladenylate synthase
DL538_19725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DL538_19745	COG2890	protein-(glutamine-N5) methyltransferase activity
DL538_19750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DL538_19755	COG0346	lactoylglutathione lyase activity
DL538_19760	COG0789	Transcriptional regulator
DL538_19765	COG0679	Auxin Efflux Carrier
DL538_19770	COG0281	malic enzyme
DL538_19775	COG1435	thymidine kinase activity
DL538_19780	COG0254	rRNA binding
DL538_19785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DL538_19790	COG1494	fructose-1,6-bisphosphatase
DL538_19795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DL538_19800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DL538_19805	COG0191	fructose-bisphosphate aldolase activity
DL538_19810	COG2204	response regulator
DL538_19815	COG4821	SIS domain
DL538_19820	COG0504	CTP synthase activity
DL538_19825	COG3343	RNA polymerase activity
DL538_19830	COG1960	acyl-CoA dehydrogenase activity
DL538_19835	COG2181	nitrate reductase activity
DL538_19835	COG0247	lactate metabolic process
DL538_19840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DL538_19845	COG4294	response to UV
DL538_19855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DL538_19860	COG1132	(ABC) transporter
DL538_19865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DL538_19875	COG2181	nitrate reductase activity
DL538_19880	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DL538_19885	COG1140	nitrate reductase beta subunit
DL538_19890	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DL538_19895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DL538_19905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DL538_19910	COG2223	nitrite transmembrane transporter activity
DL538_19915	COG0018	arginyl-trna synthetase
DL538_19920	COG4506	Protein conserved in bacteria
DL538_19935	COG0535	radical SAM domain protein
DL538_19945	COG1131	(ABC) transporter
DL538_19950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DL538_19955	COG0612	Peptidase, M16
DL538_19960	COG0612	Peptidase, M16
DL538_19970	COG3391	amine dehydrogenase activity
DL538_19975	COG3391	amine dehydrogenase activity
DL538_19985	COG0457	Tetratricopeptide repeat
DL538_20015	COG1131	(ABC) transporter
DL538_20025	COG0010	Belongs to the arginase family
DL538_20030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DL538_20035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DL538_20050	COG1994	Peptidase M50
DL538_20055	COG1942	4-Oxalocrotonate Tautomerase
DL538_20060	COG1846	Transcriptional regulator
DL538_20065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DL538_20070	COG0477	Major facilitator Superfamily
DL538_20075	COG1959	2 iron, 2 sulfur cluster binding
DL538_20080	COG3465	dGTPase activity
DL538_20085	COG1078	dGTPase activity
DL538_20090	COG4844	belongs to the
DL538_20100	COG0697	spore germination
DL538_20105	COG0095	Lipoate-protein ligase
DL538_20110	COG0583	DNA-binding transcription factor activity
DL538_20115	COG0280	phosphate acetyltransferase
DL538_20125	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_20130	COG0436	Aminotransferase
DL538_20135	COG2814	Major facilitator Superfamily
DL538_20140	COG0151	Belongs to the GarS family
DL538_20145	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_20150	COG1917	Cupin 2, conserved barrel domain protein
DL538_20155	COG0077	Prephenate dehydratase
DL538_20160	COG2814	Major facilitator Superfamily
DL538_20165	COG0833	amino acid
DL538_20170	COG4187	Peptidase family M20/M25/M40
DL538_20175	COG1012	belongs to the aldehyde dehydrogenase family
DL538_20180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DL538_20190	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DL538_20195	COG1091	dTDP-4-dehydrorhamnose reductase activity
DL538_20200	COG1088	dTDP-glucose 4,6-dehydratase activity
DL538_20205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DL538_20210	COG3980	spore coat polysaccharide biosynthesis protein
DL538_20215	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DL538_20220	COG2089	acid synthase
DL538_20225	COG0456	acetyltransferase
DL538_20230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DL538_20235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DL538_20240	COG0463	Glycosyl transferase, family 2
DL538_20255	COG2363	Small membrane protein
DL538_20260	COG2233	PERMEase
DL538_20270	COG1012	belongs to the aldehyde dehydrogenase family
DL538_20275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DL538_20280	COG1216	Glycosyl transferase, family 2
DL538_20295	COG1695	Transcriptional regulator
DL538_20300	COG0351	phosphomethylpyrimidine kinase
DL538_20310	COG1621	beta-fructofuranosidase activity
DL538_20315	COG1263	PTS System
DL538_20315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_20320	COG2116	formate transmembrane transporter activity
DL538_20325	COG3711	transcriptional antiterminator
DL538_20335	COG1404	Belongs to the peptidase S8 family
DL538_20340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DL538_20345	COG0778	Nitroreductase
DL538_20350	COG0772	Belongs to the SEDS family
DL538_20360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DL538_20365	COG1845	cytochrome c oxidase, subunit III
DL538_20370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DL538_20375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DL538_20380	COG2261	transglycosylase associated protein
DL538_20385	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DL538_20390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DL538_20395	COG2246	polysaccharide biosynthetic process
DL538_20400	COG1309	transcriptional regulator
DL538_20410	COG3162	membrane
DL538_20415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DL538_20420	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DL538_20425	COG2837	iron assimilation
DL538_20430	COG2822	iron ion transport
DL538_20435	COG0672	)-iron permease
DL538_20440	COG0352	thiamine-phosphate diphosphorylase activity
DL538_20445	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DL538_20450	COG0583	DNA-binding transcription factor activity
DL538_20455	COG1380	Effector of murein hydrolase LrgA
DL538_20460	COG1346	cytolysis
DL538_20465	COG2814	Major facilitator Superfamily
DL538_20470	COG4895	conserved protein (DUF2196)
DL538_20475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DL538_20480	COG0346	lactoylglutathione lyase activity
DL538_20485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DL538_20490	COG1404	Belongs to the peptidase S8 family
DL538_20495	COG1263	PTS System
DL538_20495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_20500	COG3711	transcriptional antiterminator
DL538_20505	COG1442	glycosyl transferase family 8
DL538_20510	COG5522	Integral membrane protein (intg_mem_TP0381)
DL538_20515	COG1846	Transcriptional regulator
DL538_20520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DL538_20525	COG2234	aminopeptidase activity
DL538_20540	COG2814	Major facilitator Superfamily
DL538_20545	COG2357	RelA SpoT domain protein
DL538_20550	COG1575	Belongs to the MenA family. Type 1 subfamily
DL538_20565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DL538_20570	COG1696	Membrane protein involved in D-alanine export
DL538_20575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DL538_20580	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DL538_20585	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DL538_20590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DL538_20595	COG1486	melibiose metabolic process
DL538_20600	COG1447	Phosphotransferase system cellobiose-specific component IIA
DL538_20605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DL538_20610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DL538_20615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DL538_20615	COG3711	transcriptional antiterminator
DL538_20625	COG2094	Belongs to the DNA glycosylase MPG family
DL538_20630	COG0753	catalase activity
DL538_20635	COG2814	Major facilitator Superfamily
DL538_20640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DL538_20645	COG1131	(ABC) transporter
DL538_20665	COG1595	DNA-templated transcription, initiation
DL538_20670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DL538_20675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DL538_20680	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DL538_20685	COG4988	ABC transporter
DL538_20690	COG1294	oxidase, subunit
DL538_20695	COG1271	oxidase subunit
DL538_20700	COG3493	citrate carrier protein
DL538_20705	COG0501	Belongs to the peptidase M48B family
DL538_20715	COG0726	polysaccharide deacetylase
DL538_20720	COG3842	ATPase activity
DL538_20725	COG2508	Transcriptional regulator
DL538_20730	COG1012	belongs to the aldehyde dehydrogenase family
DL538_20735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DL538_20750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DL538_20760	COG4585	Histidine kinase
DL538_20765	COG2197	response regulator
DL538_20770	COG2195	Cleaves the N-terminal amino acid of tripeptides
DL538_20780	COG4894	glucomannan catabolic process
DL538_20785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DL538_20790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DL538_20795	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_20800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DL538_20805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DL538_20810	COG2610	gluconate transmembrane transporter activity
DL538_20815	COG0500	methyltransferase
DL538_20820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DL538_20835	COG0693	protein deglycase activity
DL538_20835	COG0753	catalase activity
DL538_20840	COG2851	Citrate transporter
DL538_20845	COG2273	Hydrolase Family 16
DL538_20850	COG3711	transcriptional antiterminator
DL538_20860	COG2270	Major facilitator Superfamily
DL538_20865	COG0513	Belongs to the DEAD box helicase family
DL538_20870	COG3401	FG-GAP repeat protein
DL538_20870	COG2755	lipolytic protein G-D-S-L family
DL538_20925	COG3209	COG3209 Rhs family protein
DL538_20930	COG0697	spore germination
DL538_20935	COG0589	response to stress
DL538_20940	COG2723	6-phospho-beta-galactosidase activity
DL538_20945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_20945	COG2190	(PTS) system
DL538_20945	COG1263	PTS System
DL538_21000	COG5444	nuclease activity
DL538_21015	COG3507	Belongs to the glycosyl hydrolase 43 family
DL538_21030	COG2986	histidine ammonia-lyase
DL538_21035	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DL538_21040	COG1228	amidohydrolase
DL538_21045	COG0010	Belongs to the arginase family
DL538_21050	COG0833	amino acid
DL538_21055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DL538_21060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DL538_21065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DL538_21070	COG2390	Transcriptional regulator
DL538_21080	COG3192	ethanolamine utilization protein
DL538_21085	COG2079	MmgE PrpD family protein
DL538_21095	COG1126	abc transporter atp-binding protein
DL538_21100	COG0765	amino acid transport
DL538_21105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DL538_21125	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DL538_21130	COG0561	phosphatase activity
DL538_21160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DL538_21165	COG5294	Protein conserved in bacteria
DL538_21170	COG0577	efflux transmembrane transporter activity
DL538_21175	COG1136	(ABC) transporter
DL538_21180	COG2205	protein histidine kinase activity
DL538_21185	COG0745	RESPONSE REGULATOR receiver
DL538_21190	COG0191	fructose-bisphosphate aldolase activity
DL538_21195	COG1082	Xylose isomerase domain protein TIM barrel
DL538_21200	COG1082	Xylose isomerase domain protein TIM barrel
DL538_21205	COG0673	inositol 2-dehydrogenase activity
DL538_21210	COG2814	Major facilitator Superfamily
DL538_21215	COG1082	Xylose isomerase domain protein TIM barrel
DL538_21220	COG3962	Belongs to the TPP enzyme family
DL538_21225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DL538_21235	COG1012	belongs to the aldehyde dehydrogenase family
DL538_21240	COG1349	DNA-binding transcription factor activity
DL538_21245	COG0667	Aldo Keto reductase
DL538_21260	COG2814	Major facilitator Superfamily
DL538_21265	COG0326	Molecular chaperone. Has ATPase activity
DL538_21275	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_21280	COG1309	transcriptional regulator
DL538_21285	COG1012	belongs to the aldehyde dehydrogenase family
DL538_21295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DL538_21305	COG1714	RDD family
DL538_21310	COG2311	Membrane
DL538_21315	COG1917	Cupin 2, conserved barrel domain protein
DL538_21320	COG1309	transcriptional regulator
DL538_21325	COG1028	Short-chain dehydrogenase reductase Sdr
DL538_21330	COG1846	Transcriptional regulator
DL538_21335	COG1380	Effector of murein hydrolase LrgA
DL538_21340	COG1346	cytolysis
DL538_21345	COG5039	Polysaccharide pyruvyl transferase
DL538_21350	COG1929	Belongs to the glycerate kinase type-1 family
DL538_21355	COG1802	Transcriptional regulator
DL538_21360	COG1070	Carbohydrate kinase
DL538_21365	COG2610	gluconate transmembrane transporter activity
DL538_21370	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DL538_21375	COG0450	alkyl hydroperoxide reductase
DL538_21380	COG3634	alkyl hydroperoxide reductase activity
DL538_21390	COG2723	6-phospho-beta-galactosidase activity
DL538_21395	COG2190	(PTS) system
DL538_21400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DL538_21400	COG2190	(PTS) system
DL538_21400	COG1263	PTS System
DL538_21405	COG2188	Transcriptional regulator
DL538_21420	COG1131	(ABC) transporter
DL538_21425	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DL538_21435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DL538_21440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DL538_21455	COG1063	alcohol dehydrogenase
DL538_21475	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
DL538_21480	COG0456	acetyltransferase
DL538_21485	COG0457	Tetratricopeptide repeat
DL538_21495	COG0010	Belongs to the arginase family
DL538_21500	COG0833	amino acid
DL538_21505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DL538_21525	COG5658	integral membrane protein
DL538_21530	COG0640	Transcriptional regulator
DL538_21535	COG3829	transcription factor binding
DL538_21540	COG5002	protein histidine kinase activity
DL538_21560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DL538_21565	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DL538_21570	COG4853	Protein conserved in bacteria
DL538_21575	COG4863	YycH protein
DL538_21580	COG5002	protein histidine kinase activity
DL538_21585	COG0745	RESPONSE REGULATOR receiver
DL538_21615	COG0346	lactoylglutathione lyase activity
DL538_21620	COG0305	Participates in initiation and elongation during chromosome replication
DL538_21635	COG3093	addiction module antidote protein HigA
DL538_21640	COG2807	transmembrane transport
DL538_21645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DL538_21650	COG0359	binds to the 23S rRNA
DL538_21655	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DL538_21660	COG4241	membrane
DL538_21670	COG5577	PFAM Coat F domain
DL538_21675	COG1733	regulation of RNA biosynthetic process
DL538_21680	COG1227	inorganic diphosphatase activity
DL538_21690	COG2271	Major facilitator Superfamily
DL538_21695	COG0789	Transcriptional regulator
DL538_21695	COG4978	Transcriptional regulator
DL538_21705	COG4319	ketosteroid isomerase
DL538_21710	COG1357	PFAM Pentapeptide repeats (8 copies)
DL538_21715	COG2814	Major facilitator Superfamily
DL538_21720	COG0583	DNA-binding transcription factor activity
DL538_21725	COG2153	protein acetylation
DL538_21740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DL538_21745	COG1846	Transcriptional regulator
DL538_21750	COG2153	protein acetylation
DL538_21755	COG2364	Membrane
DL538_21760	COG0456	acetyltransferase
DL538_21765	COG2315	Protein conserved in bacteria
DL538_21770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DL538_21780	COG2814	Major facilitator Superfamily
DL538_21790	COG1331	Highly conserved protein containing a thioredoxin domain
DL538_21795	COG1733	regulation of RNA biosynthetic process
DL538_21805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DL538_21810	COG0798	PFAM Bile acid sodium symporter
DL538_21815	COG0346	lactoylglutathione lyase activity
DL538_21820	COG0640	Transcriptional regulator
DL538_21830	COG1331	Highly conserved protein containing a thioredoxin domain
DL538_21835	COG1266	CAAX protease self-immunity
DL538_21840	COG0477	Major facilitator Superfamily
DL538_21840	COG2814	Major facilitator Superfamily
DL538_21845	COG0110	maltose O-acetyltransferase activity
DL538_21850	COG0346	lactoylglutathione lyase activity
DL538_21855	COG1609	Transcriptional regulator
DL538_21860	COG0708	Exodeoxyribonuclease III
DL538_21865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DL538_21870	COG0629	single-stranded DNA binding
DL538_21875	COG0360	Binds together with S18 to 16S ribosomal RNA
DL538_21880	COG0012	GTP binding
DL538_21885	COG0243	molybdopterin cofactor binding
DL538_21890	COG4481	Protein conserved in bacteria
DL538_21895	COG3949	Membrane
DL538_21905	COG1475	DNA binding
DL538_21910	COG1192	Involved in chromosome partitioning
DL538_21920	COG1475	DNA binding
DL538_21925	COG0357	Ribosomal RNA small subunit methyltransferase G
DL538_21930	COG0445	tRNA wobble uridine modification
DL538_21935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DL538_21940	COG1847	R3H domain protein
DL538_21945	COG0706	membrane insertase activity
DL538_21950	COG0594	ribonuclease P activity
DL538_21955	COG0230	Belongs to the bacterial ribosomal protein bL34 family