locus-tag class description D9C16_00010 ENOG4108P49 AntiSigma factor D9C16_00015 ENOG4105JVQ RNA Polymerase D9C16_00020 ENOG4108NGU Transcriptional regulator D9C16_00025 ENOG4105N14 lysine exporter protein LysE YggA D9C16_00030 ENOG4105C85 amino acid D9C16_00040 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D9C16_00045 ENOG4105YHU PTS system D9C16_00050 ENOG4108IQ3 PTS system D9C16_00055 ENOG4105ETZ PTS System D9C16_00060 ENOG4105F3R pts system mannose fructose sorbose family iid D9C16_00065 ENOG4108HKT sucrose-6-phosphate hydrolase D9C16_00070 ENOG4108Z0Z intracellular protease Pfpi family D9C16_00075 ENOG4105DQ4 alcohol dehydrogenase D9C16_00085 ENOG4105VUF Transcriptional regulator D9C16_00100 ENOG4105E2A Dehydrogenase D9C16_00105 ENOG4105PGS Spore coat protein D9C16_00115 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase D9C16_00125 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein D9C16_00130 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein D9C16_00140 ENOG4105X5K response regulator receiver protein D9C16_00145 ENOG41083Q9 chitosanase D9C16_00150 ENOG4105CPC Aldo Keto reductase D9C16_00155 ENOG410904A RNA polymerase D9C16_00160 ENOG4108MEK Metal-binding protein YodA D9C16_00180 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D9C16_00195 ENOG4105EA8 2-Nitropropane dioxygenase D9C16_00200 ENOG41075D4 Aminoglycoside 6-adenylyltransferase D9C16_00215 ENOG41064BW Protein of unknown function (DUF2568) D9C16_00235 ENOG41067XF inhibitor D9C16_00240 ENOG4108ZRZ Transcriptional regulator (AsnC family) D9C16_00250 ENOG4105KMT branched-chain amino acid D9C16_00265 ENOG4105PGM cation diffusion facilitator family transporter D9C16_00270 ENOG4105H3G oxidoreductase D9C16_00275 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family D9C16_00290 ENOG4105C37 (CBS) domain D9C16_00305 ENOG41090E6 transcriptional regulator MERR family D9C16_00365 ENOG4105EN2 IstB domain-containing protein ATP-binding protein D9C16_00370 ENOG4106QJ6 Integrase catalytic subunit D9C16_00445 ENOG4107RSM transcriptional regulator D9C16_00465 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9C16_00470 ENOG4105WFK nuclease D9C16_00485 ENOG41080BT SNARE associated Golgi D9C16_00490 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase D9C16_00505 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase D9C16_00510 ENOG4105CQW ribosome biogenesis GTPase YqeH D9C16_00515 ENOG4105E2X shikimate dehydrogenase D9C16_00520 ENOG410812S Rna-binding protein D9C16_00525 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) D9C16_00530 ENOG4108WF2 Metal Dependent Phosphohydrolase D9C16_00540 ENOG4108D32 Methyltransferase D9C16_00550 ENOG4105KQC Competence protein D9C16_00555 ENOG4108UK2 deaminase D9C16_00560 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 D9C16_00575 ENOG4105TQK DNA polymerase iii, delta' subunit D9C16_00580 ENOG41082YS Binds directly to 16S ribosomal RNA D9C16_00585 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) D9C16_00590 ENOG4108ZRV stage ii sporulation protein p D9C16_00600 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D9C16_00605 ENOG4105CSA Coproporphyrinogen iii oxidase D9C16_00610 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) D9C16_00615 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D9C16_00620 ENOG4105CFG Acts as a chaperone (By similarity) D9C16_00630 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D9C16_00635 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D9C16_00640 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D9C16_00655 ENOG4105KTH gatB Yqey D9C16_00660 ENOG4105F7J membrane-bound serine protease D9C16_00665 ENOG4105DI5 UPF0365 protein D9C16_00675 ENOG41068P3 sporulation protein YqfC D9C16_00680 ENOG4105EI1 sporulation protein yqfd D9C16_00685 ENOG4105C9A Phoh family D9C16_00695 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D9C16_00700 ENOG4107YR5 Diacylglycerol kinase D9C16_00705 ENOG4105KG3 cytidine deaminase D9C16_00710 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D9C16_00720 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) D9C16_00725 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit D9C16_00730 ENOG4105C38 Glycyl-tRNA synthetase beta subunit D9C16_00740 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D9C16_00745 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 D9C16_00750 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D9C16_00755 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9C16_00775 ENOG4105EGD dinuclear metal center protein, YbgI family D9C16_00780 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) D9C16_00795 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) D9C16_00800 ENOG41069ZM Protein of unknown function (DUF2624) D9C16_00805 ENOG4108JYZ YitT family D9C16_00810 ENOG4105N80 Ferric uptake regulator, Fur family D9C16_00815 ENOG4108U5J '-nucleotidase D9C16_00820 ENOG41063Y9 D9C16_00825 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D9C16_00840 ENOG4105SXS Protein of unknown function (DUF456) D9C16_00845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D9C16_00855 ENOG4107RF6 penicillin-binding protein D9C16_00860 ENOG4105CVA phosphate D9C16_00865 ENOG4105C8U phosphate abc transporter D9C16_00870 ENOG4105E2Z phosphate ABC transporter (Permease D9C16_00875 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D9C16_00880 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D9C16_00885 ENOG41068DG YceG-like family D9C16_00905 ENOG4105WDJ 50S ribosomal protein L33 D9C16_00910 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase D9C16_00920 ENOG4107ZXI Rhomboid family D9C16_00935 ENOG4105E0M Sulfatase D9C16_00960 ENOG4105C5X domain protein D9C16_00985 ENOG4105C37 (CBS) domain D9C16_00995 ENOG41080XP Cbs domain D9C16_01050 ENOG4105VFR signal peptidase D9C16_01060 ENOG4108IMY Transcriptional regulator D9C16_01075 ENOG4105C0D helicase D9C16_01080 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D9C16_01085 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D9C16_01090 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D9C16_01095 ENOG4105WZW rhodanese family D9C16_01100 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) D9C16_01105 ENOG4105KST dependent repressor D9C16_01120 ENOG4105CBJ Metal-dependent enzyme D9C16_01130 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) D9C16_01135 ENOG4105DC7 peptidase M24 D9C16_01140 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D9C16_01150 ENOG4105CD2 stage iii sporulation protein aa D9C16_01155 ENOG4105KR5 Stage iii sporulation protein D9C16_01160 ENOG4108CQH stage III sporulation protein AC D9C16_01165 ENOG4105KQ4 Stage iii sporulation protein ad D9C16_01175 ENOG410644B Stage III sporulation protein af D9C16_01200 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D9C16_01205 ENOG4108ZSR alkaline shock protein D9C16_01210 ENOG4105M7K Involved in the transcription termination process (By similarity) D9C16_01215 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D9C16_01220 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D9C16_01225 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D9C16_01230 ENOG4105CTB Polyprenyl synthetase D9C16_01240 ENOG4105DX0 Hemolysin A D9C16_01245 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) D9C16_01250 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D9C16_01255 ENOG4105S1Z Stage IV sporulation protein B D9C16_01265 ENOG4107QQR Sporulation D9C16_01270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D9C16_01285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D9C16_01290 ENOG4108QXE glycerophosphoryl diester phosphodiesterase D9C16_01300 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D9C16_01305 ENOG4105C1G acyl-Coa dehydrogenase D9C16_01315 ENOG4105DXD 2-methylcitrate dehydratase D9C16_01320 ENOG4105CR4 methylisocitrate lyase D9C16_01325 ENOG4106CCJ Protein of unknown function (DUF2627) D9C16_01330 ENOG4108JUB Transcriptional regulator D9C16_01340 ENOG4107RDP Dehydrogenase D9C16_01345 ENOG4105CKM Branched-chain carboxylic acid kinase D9C16_01360 ENOG4105CPP Dehydrogenase, E1 component D9C16_01365 ENOG4105C7S Dehydrogenase D9C16_01380 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) D9C16_01385 ENOG4108Y6J UPF0403 protein D9C16_01390 ENOG4108HW3 (ABC) transporter D9C16_01395 ENOG4105E5Q amino acid AbC transporter D9C16_01400 ENOG4105CDA abc transporter atp-binding protein D9C16_01405 ENOG4108QEG Membrane D9C16_01410 ENOG4108VZI ErfK ybiS ycfS ynhG family protein D9C16_01415 ENOG4108ZVT methylmalonyl-coA epimerase D9C16_01425 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) D9C16_01430 ENOG4108NA0 Uncharacterized conserved protein (COG2071) D9C16_01435 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) D9C16_01445 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D9C16_01450 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D9C16_01455 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase D9C16_01460 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) D9C16_01465 ENOG410861F 50S ribosomal protein L33 D9C16_01485 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D9C16_01495 ENOG4105II7 pyrroline-5-carboxylate reductase D9C16_01500 ENOG41069FQ Metallo-beta-lactamase superfamily D9C16_01505 ENOG4108IXY short-chain dehydrogenase reductase D9C16_01520 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase D9C16_01525 ENOG4105E5W Transporter D9C16_01535 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D9C16_01545 ENOG4108XET gCN5-related N-acetyltransferase D9C16_01550 ENOG4105KAC Antibiotic biosynthesis monooxygenase D9C16_01555 ENOG4105RHY Pfam:UPF0157 D9C16_01560 ENOG4106HZJ D9C16_01580 ENOG4105CPC Aldo Keto reductase D9C16_01590 ENOG4108YZ4 nudix hydrolase D9C16_01600 ENOG4108IMY Transcriptional regulator D9C16_01605 ENOG4105HDK L-asparaginase D9C16_01610 ENOG4108IJ0 Aspartate ammonia-lyase D9C16_01615 ENOG4105DFD Na H antiporter D9C16_01630 ENOG4105MZ9 stage II sporulation protein m D9C16_01635 ENOG4105I3K Ferric uptake regulator, Fur family D9C16_01645 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D9C16_01650 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) D9C16_01655 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) D9C16_01660 ENOG4105DZ1 carboxypeptidase D9C16_01665 ENOG41082AN stage II sporulation protein D9C16_01670 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) D9C16_01675 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9C16_01690 ENOG41090VF Stage v sporulation protein ac D9C16_01695 ENOG4105CZ3 stage V sporulation protein ad D9C16_01705 ENOG4105G6R Stage v sporulation protein ae D9C16_01715 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D9C16_01720 ENOG4105PTM secreted protein D9C16_01735 ENOG4107ZE5 PPIases accelerate the folding of proteins D9C16_01840 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) D9C16_01850 ENOG4105C3F Signal peptidase i D9C16_01860 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D9C16_01865 ENOG4108R6K riboflavin synthase, subunit alpha D9C16_01870 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D9C16_01875 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D9C16_01890 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) D9C16_01895 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) D9C16_01905 ENOG4105DZ1 carboxypeptidase D9C16_01910 ENOG4108JIC nucleoside recognition domain protein D9C16_01920 ENOG4105FE9 pseudouridine synthase D9C16_01930 ENOG4107TWT Cytochrome c biogenesis protein D9C16_01935 ENOG4105CRE cytochrome C D9C16_01940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D9C16_01945 ENOG4105BZU Histidine kinase D9C16_01960 ENOG4105FF2 Type I DHQase D9C16_01965 ENOG4108JQ1 Dehydrogenase D9C16_01970 ENOG4108SAX Membrane D9C16_01980 ENOG4105T7X D9C16_01985 ENOG4105C9U ATP-dependent DNA helicase RecQ D9C16_01990 ENOG4105I7S Abortive infection protein D9C16_02020 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase D9C16_02025 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) D9C16_02035 ENOG4105MSI germination protein ypeb D9C16_02050 ENOG4105CAT Cytidine monophosphate kinase D9C16_02055 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D9C16_02060 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) D9C16_02075 ENOG4105S2F D9C16_02080 ENOG41065D1 D9C16_02085 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D9C16_02090 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D9C16_02105 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) D9C16_02110 ENOG4105K70 DNA-binding protein D9C16_02115 ENOG4105EUJ GTP cyclohydrolase i D9C16_02125 ENOG4105XXQ heptaprenyl diphosphate synthase component I D9C16_02130 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D9C16_02135 ENOG4105EAH synthase D9C16_02140 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D9C16_02145 ENOG4105BZU Histidine kinase D9C16_02150 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D9C16_02155 ENOG4105D49 3-dehydroquinate synthase D9C16_02160 ENOG4105KHN chorismate mutase D9C16_02165 ENOG4105CRQ synthase (Component I) D9C16_02180 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase D9C16_02185 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D9C16_02205 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D9C16_02210 ENOG41068YB TPR repeat-containing protein D9C16_02230 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D9C16_02250 ENOG4108JYZ YitT family D9C16_02255 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase D9C16_02260 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D9C16_02265 ENOG4108Z5K methylglyoxal synthase D9C16_02270 ENOG4105FJR Lmbe family D9C16_02275 ENOG4105CPK Glycosyl transferase (Group 1 D9C16_02280 ENOG4105DJ0 Poly(A) Polymerase D9C16_02285 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase D9C16_02290 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D9C16_02295 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D9C16_02300 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) D9C16_02305 ENOG4105DVT helicase D9C16_02310 ENOG4105YAC D9C16_02320 ENOG4105CHM Aminotransferase D9C16_02325 ENOG4105C5S asparaginyl-tRNA synthetase D9C16_02335 ENOG4105CSM endonuclease III D9C16_02345 ENOG4105BZ4 penicillin-binding protein D9C16_02395 ENOG4108I5C dEAD DEAH box helicase D9C16_02400 ENOG4107X2U Inherit from COG: Exonuclease-like protein D9C16_02415 ENOG4108UKS UPF0398 protein D9C16_02430 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D9C16_02445 ENOG4105DVT helicase D9C16_02450 ENOG4105CHR reductase D9C16_02460 ENOG4108M60 Transcriptional regulator D9C16_02465 ENOG4105D7K pfkb domain protein D9C16_02470 ENOG4108UHU Aldolase D9C16_02475 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) D9C16_02480 ENOG4105CTD carboxy-peptidase D9C16_02485 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) D9C16_02490 ENOG4105C2W permease D9C16_02495 ENOG41065KQ synthase D9C16_02510 ENOG410890F Dynamin family D9C16_02535 ENOG41081VK Ribonuclease D9C16_02580 ENOG4105CVG Homoserine O-transsuccinylase D9C16_02585 ENOG4108V06 Glutathione peroxidase D9C16_02600 ENOG4105C01 Dihydroxy-acid dehydratase D9C16_02605 ENOG4108Y6J UPF0403 protein D9C16_02610 ENOG4107YX5 Pfam:DUF548 D9C16_02625 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D9C16_02635 ENOG4108UT2 hemolysin iii D9C16_02645 ENOG4105C7B Threonine dehydratase D9C16_02655 ENOG4108KF3 Electron transport protein SCO1 SenC D9C16_02660 ENOG41090WU lipolytic protein G-D-S-L family D9C16_02665 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) D9C16_02685 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D9C16_02690 ENOG4105E0X reductase D9C16_02695 ENOG4105C5E polysaccharide biosynthesis protein D9C16_02700 ENOG4107T32 3-phytase (EC 3.1.3.8) D9C16_02740 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D9C16_02755 ENOG4107S4Y M20 DapE family protein YgeY D9C16_02760 ENOG4108TSC N-acetyltransferase D9C16_02765 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D9C16_02800 ENOG410841Q phosphoesterase PA-phosphatase related protein D9C16_02805 ENOG4106Z5R D9C16_02815 ENOG4105D3A purine nucleoside phosphorylase DeoD-type D9C16_02820 ENOG4108VXD carboxy-peptidase D9C16_02840 ENOG4105E1V na solute symporter D9C16_02855 ENOG4105FBA Phospholipase Carboxylesterase D9C16_02875 ENOG41090U3 tautomerase D9C16_02895 ENOG4105FR1 rard protein D9C16_02915 ENOG4106SCS STAS domain D9C16_02920 ENOG4107QMU Mate efflux family protein D9C16_02930 ENOG41087PP glycosyltransferase MGT family D9C16_02935 ENOG4105K4H Nlp p60 protein D9C16_02945 ENOG4105GMT ATPase associated with various cellular activities aaa_5 D9C16_02950 ENOG4107T89 von Willebrand factor, type A D9C16_02960 ENOG4105C7S Dehydrogenase D9C16_02965 ENOG4105C09 Bile acid D9C16_02970 ENOG4105C8J )-transporter D9C16_02975 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D9C16_02980 ENOG4105EWU Squalene--hopene cyclase D9C16_02985 ENOG4105C26 Dehydrogenase D9C16_03025 ENOG4105SCY DNAK suppressor D9C16_03030 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D9C16_03045 ENOG4105C9U ATP-dependent DNA helicase RecQ D9C16_03050 ENOG41069ER domain protein D9C16_03055 ENOG4108S01 response regulator D9C16_03060 ENOG4108ZGX Histidine kinase D9C16_03065 ENOG4105ECK Fatty Acid Desaturase D9C16_03085 ENOG4108SJC Membrane D9C16_03095 ENOG4105KTU Transcriptional regulator, arsr family D9C16_03105 ENOG4105D29 Helix-turn-helix type 11 domain protein D9C16_03115 ENOG4108W8B Beta-lactamase domain protein D9C16_03125 ENOG4108HJF gCN5-related N-acetyltransferase D9C16_03130 ENOG4105FTV AraC Family Transcriptional Regulator D9C16_03135 ENOG4108Z7R Chaperone CsaA D9C16_03150 ENOG4106BHF D9C16_03155 ENOG4106ANW SMI1_KNR4 D9C16_03170 ENOG4105UA4 acetyltransferase D9C16_03210 ENOG4105IE8 Alpha-ketoglutarate permease D9C16_03220 ENOG4105CJ1 ABC, transporter D9C16_03235 ENOG41068WN D9C16_03240 ENOG4108UB7 D9C16_03280 ENOG4105C5Q Transcriptional regulator D9C16_03285 ENOG4105CBC glutamate synthase D9C16_03290 ENOG4105BZ8 glutamate synthase D9C16_03295 ENOG4105CB2 alcohol dehydrogenase D9C16_03300 ENOG4105SKE transcriptional Regulator LysR family D9C16_03305 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D9C16_03335 ENOG4107QJQ Mate efflux family protein D9C16_03340 ENOG4108N2V aldose 1-epimerase D9C16_03345 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family D9C16_03350 ENOG4105CEY Amp-dependent synthetase and ligase D9C16_03360 ENOG4106U2H Protein of unknown function (DUF1360) D9C16_03365 ENOG4105F32 YngK protein D9C16_03375 ENOG4105C1G acyl-Coa dehydrogenase D9C16_03380 ENOG4105CEY Amp-dependent synthetase and ligase D9C16_03385 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D9C16_03390 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit D9C16_03395 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D9C16_03400 ENOG4105E39 Enoyl-CoA hydratase D9C16_03405 ENOG4107QX3 carboxylase D9C16_03415 ENOG4107T5V SNARE associated Golgi D9C16_03420 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D9C16_03445 ENOG4107QWR cellulase (EC 3.2.1.4) D9C16_03465 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D9C16_03470 ENOG4105K4P CoA-binding domain protein D9C16_03475 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D9C16_03480 ENOG4105W8X HesB YadR YfhF-family protein D9C16_03485 ENOG4105MI2 D9C16_03495 ENOG41067CD Small, acid-soluble spore protein Tlp D9C16_03510 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D9C16_03515 ENOG4108I0Z Aconitate hydratase D9C16_03525 ENOG4107DZX Small, acid-soluble spore protein P D9C16_03550 ENOG4107QIV Cytochrome c biogenesis protein D9C16_03570 ENOG4105CV1 Transketolase (EC 2.2.1.1) D9C16_03575 ENOG4105VPS UPF0291 protein D9C16_03580 ENOG4108SVB resolvase D9C16_03590 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D9C16_03600 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) D9C16_03610 ENOG4105K7W phage-related replication protein D9C16_03620 ENOG4105FVX D9C16_03715 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D9C16_03730 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D9C16_03735 ENOG4105C54 Major Facilitator superfamily D9C16_03740 ENOG4107Y9E nuclease D9C16_03770 ENOG4105CMG Carbohydrate kinase D9C16_03775 ENOG4105C93 Xylose Isomerase D9C16_03780 ENOG4105E2R ROK family D9C16_03785 ENOG4105DSG hydrolase family 43 D9C16_03800 ENOG4105CT4 transporter D9C16_03805 ENOG410907G D9C16_03830 ENOG4107NTZ D9C16_03850 ENOG4106QJ6 Integrase catalytic subunit D9C16_03855 ENOG4105EN2 IstB domain-containing protein ATP-binding protein D9C16_03890 ENOG41079P0 D9C16_03910 ENOG4106BHF D9C16_03915 ENOG4106ANW SMI1_KNR4 D9C16_03920 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase D9C16_03945 ENOG41068G1 D9C16_03965 ENOG4108FKH Transglycosylase SLT domain D9C16_04110 ENOG4108ZUE Phage regulatory protein rha D9C16_04130 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D9C16_04135 ENOG4105C5F glutamine synthetase D9C16_04140 ENOG4105KV4 Transcriptional regulator D9C16_04145 ENOG4105CXI aluminum resistance protein D9C16_04150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D9C16_04155 ENOG4106F1P AAA ATPase, central domain protein D9C16_04165 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D9C16_04170 ENOG4105U6W MutT NUDIX family protein D9C16_04175 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D9C16_04180 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D9C16_04185 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) D9C16_04200 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) D9C16_04205 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D9C16_04225 ENOG410814C multidrug resistance protein D9C16_04230 ENOG4108X3M OsmC Ohr family protein D9C16_04235 ENOG4105K7W phage-related replication protein D9C16_04245 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin D9C16_04260 ENOG4105W1N transcriptional regulator D9C16_04265 ENOG4105IIP Membrane D9C16_04355 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D9C16_04360 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D9C16_04375 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D9C16_04380 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D9C16_04390 ENOG4105MCT stage V sporulation protein S D9C16_04395 ENOG4105D48 metallophosphoesterase D9C16_04400 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) D9C16_04405 ENOG4108A04 Beta-lactamase D9C16_04415 ENOG4105CEV competence damage-inducible protein D9C16_04420 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase D9C16_04435 ENOG4105XZV Protein of unknown function (DUF3243) D9C16_04440 ENOG4108RKS Short-chain dehydrogenase reductase Sdr D9C16_04460 ENOG4105FDP GntR family transcriptional regulator D9C16_04465 ENOG4105CNU cell division protein FtsK D9C16_04475 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit D9C16_04485 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D9C16_04495 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D9C16_04500 ENOG4108S0H Dipicolinic acid synthetase, b subunit D9C16_04505 ENOG4105E35 Dipicolinate synthase subunit A D9C16_04515 ENOG4105C1V Peptidase, M16 D9C16_04525 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) D9C16_04530 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D9C16_04535 ENOG4105DTN riboflavin biosynthesis protein ribF D9C16_04540 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D9C16_04545 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D9C16_04550 ENOG4105W7A Protein of unknown function (DUF503) D9C16_04555 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) D9C16_04560 ENOG4105VHM ribosomal protein D9C16_04565 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination D9C16_04570 ENOG4105CHV Transcription elongation factor NusA D9C16_04575 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) D9C16_04580 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) D9C16_04585 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D9C16_04590 ENOG4105DZP Membrane-associated zinc metalloprotease D9C16_04600 ENOG4105KNE Phosphatidate cytidylyltransferase D9C16_04605 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D9C16_04610 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) D9C16_04620 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D9C16_04625 ENOG4105CE9 30S ribosomal protein S2 D9C16_04635 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9C16_04650 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis D9C16_04655 ENOG4105CBS Chea signal transduction histidine kinase D9C16_04660 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D9C16_04670 ENOG4105FZW flagellar biosynthesis regulator FlhF D9C16_04675 ENOG4105D7B Flagellar biosynthesis protein flha D9C16_04680 ENOG4105D00 flagellar biosynthetic protein flhB D9C16_04685 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D9C16_04690 ENOG4105VS8 Flagellar biosynthetic protein fliq D9C16_04695 ENOG4105CN7 Flagellar biosynthetic protein FliP D9C16_04705 ENOG4107YTP response regulator receiver protein D9C16_04710 ENOG4105DD5 Flagellar motor switch protein D9C16_04715 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D9C16_04725 ENOG41068WV flagellar FlbD family protein D9C16_04730 ENOG4108JQA flagellar D9C16_04735 ENOG410822I Flagellar hook capping protein D9C16_04740 ENOG410696Y Flagellar hook-length control protein D9C16_04750 ENOG4106YF4 Flagellar biosynthesis chaperone D9C16_04765 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D9C16_04775 ENOG4105VQ0 flagellar hook-basal body complex protein fliE D9C16_04780 ENOG4108ZC9 flagellar basal-body rod protein flgc D9C16_04785 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D9C16_04795 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D9C16_04800 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) D9C16_04805 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D9C16_04810 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) D9C16_04815 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D9C16_04820 ENOG4105C79 DNA protecting protein DprA D9C16_04825 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D9C16_04830 ENOG4105CMV Succinyl-CoA synthetase subunit beta D9C16_04835 ENOG4105VM1 flagellar D9C16_04845 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D9C16_04850 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) D9C16_04855 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D9C16_04860 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D9C16_04865 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D9C16_04875 ENOG4108BW8 UPF0109 protein D9C16_04880 ENOG4105K5M 30s ribosomal protein S16 D9C16_04890 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) D9C16_04900 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D9C16_04905 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) D9C16_04910 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D9C16_04915 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D9C16_04920 ENOG4105CHR reductase D9C16_04925 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D9C16_04935 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) D9C16_04940 ENOG4105CB5 ATP-dependent DNA helicase recG D9C16_04945 ENOG4105EJQ L-serine dehydratase D9C16_04955 ENOG4105DP4 dak2 domain fusion protein ylov D9C16_04960 ENOG4108ZAA Alkaline-shock protein D9C16_04965 ENOG4105VB9 50S ribosomal protein l28 D9C16_04975 ENOG4105FJ0 thiamine D9C16_04980 ENOG4105DJV ribulose-phosphate 3-epimerase D9C16_04985 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D9C16_04990 ENOG4105D9P serine threonine protein kinase D9C16_04995 ENOG4108ZF3 Phosphatase D9C16_05000 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D9C16_05005 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D9C16_05010 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D9C16_05015 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D9C16_05020 ENOG4105C25 Primosomal protein n' D9C16_05025 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D9C16_05035 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D9C16_05040 ENOG4105KC4 UPF0296 protein D9C16_05045 ENOG4105DSJ YicC domain protein D9C16_05055 ENOG4105F23 Fibronectin-binding protein D9C16_05060 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein D9C16_05065 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein D9C16_05070 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D9C16_05075 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) D9C16_05080 ENOG4107S4M Sulfate adenylate transferase D9C16_05090 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) D9C16_05095 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D9C16_05100 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) D9C16_05105 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) D9C16_05110 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) D9C16_05115 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D9C16_05120 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D9C16_05130 ENOG4105CXT aspartate transcarbamylase D9C16_05140 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) D9C16_05145 ENOG4105C34 Pseudouridine synthase D9C16_05150 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D9C16_05160 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D9C16_05170 ENOG4105DBK s4 domain protein D9C16_05175 ENOG41067XK integral membrane protein D9C16_05180 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) D9C16_05185 ENOG4105DFA alanine racemase domain protein D9C16_05190 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D9C16_05195 ENOG4105WR5 sporulation protein, YlmC YmxH family D9C16_05205 ENOG4105DKW ABC transporter D9C16_05215 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9C16_05220 ENOG4105FFI sigma-e processing peptidase spoiiga D9C16_05230 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D9C16_05235 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D9C16_05240 ENOG4105K67 small basic protein D9C16_05250 ENOG4108R2U division initiation protein D9C16_05255 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) D9C16_05260 ENOG4105D4A Cell wall formation (By similarity) D9C16_05265 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D9C16_05270 ENOG4105CNI cell division protein FtsW D9C16_05275 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D9C16_05280 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D9C16_05285 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D9C16_05290 ENOG4105CJN penicillin-binding protein D9C16_05295 ENOG4105CJN penicillin-binding protein D9C16_05305 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D9C16_05310 ENOG4108V6E Cell division protein mraZ D9C16_05335 ENOG41067VY 50S ribosomal protein L32 D9C16_05340 ENOG4105KNH Nucleic acid-binding protein D9C16_05350 ENOG4105CDE UPF0348 protein D9C16_05355 ENOG41063PX domain protein D9C16_05360 ENOG4105D78 K07001 NTE family protein D9C16_05365 ENOG4105H20 Sporulation integral membrane protein YlbJ D9C16_05370 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D9C16_05375 ENOG4106H78 methyltransferase D9C16_05380 ENOG4105WUC UPF0298 protein D9C16_05400 ENOG4106UY4 Inherit from COG: Scp-like extracellular D9C16_05405 ENOG41080XQ Signal transduction protein with cbs domains D9C16_05420 ENOG41064X9 cytochrome C oxidase subunit IV D9C16_05425 ENOG4105CCU oxidase (Subunit III) D9C16_05430 ENOG4105BZ9 Cytochrome C oxidase, subunit I D9C16_05440 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D9C16_05450 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) D9C16_05455 ENOG4105CNI cell division protein FtsW D9C16_05460 ENOG4105ZPI UPF0358 protein D9C16_05465 ENOG4105CSV Glutaminase D9C16_05475 ENOG4108IAB Phoh family D9C16_05490 ENOG4105QA2 D9C16_05495 ENOG4105CI3 gtp-binding protein typa D9C16_05540 ENOG4105JQZ Methyltransferase D9C16_05555 ENOG4105ECY inositol monophosphatase D9C16_05570 ENOG4105WBI UPF0223 protein D9C16_05575 ENOG4105CXN decarboxylase D9C16_05590 ENOG4107QN2 dihydrolipoyl dehydrogenase D9C16_05595 ENOG4105C7S Dehydrogenase D9C16_05600 ENOG4105CPP Dehydrogenase, E1 component D9C16_05620 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D9C16_05625 ENOG4108X4Q Hydrolase D9C16_05635 ENOG4105CN5 Metallo-Beta-Lactamase D9C16_05645 ENOG4107ZYR domain protein D9C16_05655 ENOG4105BZU Histidine kinase D9C16_05680 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D9C16_05685 ENOG4105C5H ABC transporter D9C16_05695 ENOG4105C3F Signal peptidase i D9C16_05700 ENOG4105DM4 PTS System D9C16_05705 ENOG4105DE4 1-phosphofructokinase D9C16_05710 ENOG4105E98 transcriptional regulator DeoR family D9C16_05715 ENOG4107RBB ABC transporter, permease D9C16_05720 ENOG4105C19 ABC transporter D9C16_05725 ENOG4107X8C Efflux transporter RND family MFP subunit D9C16_05735 ENOG4105BZ1 (ABC) transporter D9C16_05745 ENOG41067WU Molybdopterin converting factor (Subunit 1) D9C16_05750 ENOG4108ZAF Molybdopterin D9C16_05755 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein D9C16_05760 ENOG4105CVM Molybdenum cofactor synthesis domain protein D9C16_05765 ENOG4105D06 uba thif-type nad fad binding protein D9C16_05770 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) D9C16_05790 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D9C16_05795 ENOG4105D3R alkyl hydroperoxide reductase D9C16_05800 ENOG4105D8X mechanosensitive ion channel D9C16_05810 ENOG4105CH2 amidohydrolase D9C16_05820 ENOG4105NQC Flavodoxin D9C16_05850 ENOG4108XRC Protein of unknown function (DUF458) D9C16_05855 ENOG4107IN1 Protein of unknown function (DUF1797) D9C16_05860 ENOG4105EPM Diguanylate phosphodiesterase D9C16_05865 ENOG4105K6S Short-chain dehydrogenase reductase Sdr D9C16_05875 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein D9C16_05885 ENOG4105UIN D9C16_05890 ENOG4107R88 Chemotaxis protein (CheV) D9C16_05900 ENOG4105CHM Aminotransferase D9C16_05905 ENOG4105BZU Histidine kinase D9C16_05915 ENOG4105K4I Scp-like extracellular D9C16_05930 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D9C16_05935 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer D9C16_05945 ENOG4105F6S Spore photoproduct lyase D9C16_05955 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D9C16_05960 ENOG4105KRI phosphocarrier protein (HPr D9C16_05970 ENOG4105CID antiterminator D9C16_05980 ENOG4105DC7 peptidase M24 D9C16_05990 ENOG4105C59 p-type ATPase D9C16_06005 ENOG4105F0V Cell wall hydrolase D9C16_06025 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D9C16_06030 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D9C16_06035 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase D9C16_06040 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D9C16_06045 ENOG4108K88 Membrane D9C16_06055 ENOG4105E14 MotA TolQ exbB proton channel D9C16_06060 ENOG4105ER2 Ompa motb domain protein D9C16_06065 ENOG41090MY MarR family Transcriptional regulator D9C16_06070 ENOG4105BZU Histidine kinase D9C16_06090 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) D9C16_06095 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) D9C16_06100 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) D9C16_06105 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit D9C16_06115 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D9C16_06120 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) D9C16_06125 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) D9C16_06135 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D9C16_06140 ENOG4105BZU Histidine kinase D9C16_06145 ENOG4108TGC Acyltransferase D9C16_06170 ENOG4105D0M Protease HtpX homolog D9C16_06180 ENOG410681C small acid-soluble spore protein D9C16_06190 ENOG4108WZW RNA polymerase sigma D9C16_06195 ENOG4107TS3 membrane protein, TerC D9C16_06200 ENOG4107T5V SNARE associated Golgi D9C16_06205 ENOG4105BZU Histidine kinase D9C16_06210 ENOG4105FDF Could be involved in DNA repair (By similarity) D9C16_06215 ENOG4105DQE DNA ligase D9C16_06260 ENOG4105V75 Transcriptional regulator D9C16_06265 ENOG4105CJW magnesium transporter D9C16_06280 ENOG4106849 propeptide, pepSY amd peptidase M4 D9C16_06290 ENOG41062D9 Histidine kinase D9C16_06295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D9C16_06300 ENOG4108X43 YKOF domain protein D9C16_06305 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein D9C16_06310 ENOG4108JJB ABC transporter D9C16_06315 ENOG4108W7F transporter, permease D9C16_06325 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin D9C16_06330 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D9C16_06335 ENOG4107Y2X deaminase D9C16_06345 ENOG4108ZHJ Organic hydroperoxide resistance protein D9C16_06350 ENOG4105K56 Transcriptional regulator D9C16_06365 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D9C16_06370 ENOG4105CIY formyltetrahydrofolate deformylase D9C16_06375 ENOG41080TC multidrug resistance protein D9C16_06385 ENOG4108428 Inherit from COG: -acetyltransferase D9C16_06405 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D9C16_06410 ENOG4108S4H thioesterase Superfamily protein D9C16_06420 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D9C16_06425 ENOG4108JQ7 (ABC) transporter D9C16_06430 ENOG4107SN7 NLP P60 protein D9C16_06435 ENOG4105DTQ mandelate racemase muconate lactonizing D9C16_06440 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A D9C16_06450 ENOG4105C3U ABC transporter D9C16_06455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D9C16_06460 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D9C16_06465 ENOG4108ME1 Peptidase M55 D-aminopeptidase D9C16_06475 ENOG4105C0H protease D9C16_06480 ENOG4105CKK Glycosyl transferase, family 2 D9C16_06485 ENOG4105EDW glycosyl transferase, family 39 D9C16_06495 ENOG4107R7I amino acid D9C16_06500 ENOG4107GRR phosphate transport regulator D9C16_06505 ENOG4105CJ3 phosphate transporter D9C16_06555 ENOG41068G1 D9C16_06565 ENOG410906S phage-like element pbsx protein xkdt D9C16_06570 ENOG41066EA baseplate J family protein D9C16_06575 ENOG4105MFU Protein of unknown function (DUF2634) D9C16_06585 ENOG4105X7F D9C16_06590 ENOG4108WZM domain protein D9C16_06605 ENOG4105MTC XkdN-like protein D9C16_06610 ENOG4105FR7 XkdM protein, phage-like element PBSX D9C16_06615 ENOG4105PQS phage protein D9C16_06630 ENOG41060SN D9C16_06655 ENOG4108MDF Phage Portal Protein D9C16_06660 ENOG4105IG6 Phage terminase, large subunit D9C16_06665 ENOG4108TFU terminase (Small subunit) D9C16_06710 ENOG410635T phage-like element pbsx protein D9C16_06715 ENOG4105WEF catalase D9C16_06720 ENOG4105K7W phage-related replication protein D9C16_06725 ENOG4105KWG Pfam:DUF1696 D9C16_06730 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase D9C16_06770 ENOG4107TSN permease D9C16_06775 ENOG4105CTX dehydratase D9C16_06785 ENOG4107KJX Transcriptional regulator D9C16_06790 ENOG4108I5G Major Facilitator superfamily D9C16_06795 ENOG4105DMW Dehydrogenase reductase D9C16_06800 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) D9C16_06805 ENOG4105CPQ Dehydrogenase D9C16_06810 ENOG4105DG4 malate L-lactate dehydrogenase D9C16_06815 ENOG4105CT4 transporter D9C16_06820 ENOG4105D2H Uronic isomerase D9C16_06845 ENOG4108IXI (ABC) transporter D9C16_06850 ENOG4105C4B ABC transporter, permease D9C16_06855 ENOG4105EXQ uroporphyrinogen iii synthase hem4 D9C16_06865 ENOG41087PP glycosyltransferase MGT family D9C16_06870 ENOG4106A3M Cytochrome p-450 D9C16_06920 ENOG4107CUJ Protein of unknown function (DUF2690) D9C16_06925 ENOG4108ZJ4 polysaccharide deacetylase D9C16_06935 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D9C16_06955 ENOG4108Z66 YbaK ebsC protein D9C16_06965 ENOG4105VMI -acetyltransferase D9C16_06980 ENOG4105G7B Protein of unknown function (DUF2992) D9C16_06985 ENOG4105DG6 mannose-6-phosphate isomerase D9C16_07075 ENOG4106ANW SMI1_KNR4 D9C16_07080 ENOG4106BHF D9C16_07085 ENOG410780I phosphoprotein phosphatase activity D9C16_07120 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) D9C16_07185 ENOG4105JHY Membrane D9C16_07190 ENOG4105D9U N-acetyltransferase D9C16_07195 ENOG4105C28 cystathionine D9C16_07200 ENOG4105C28 cystathionine D9C16_07210 ENOG4108ZMI UPF0477 protein D9C16_07225 ENOG4105ENA helicase D9C16_07275 ENOG4107A88 D9C16_07280 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D9C16_07285 ENOG4105DWF phosphomethylpyrimidine kinase D9C16_07290 ENOG4105D06 uba thif-type nad fad binding protein D9C16_07295 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D9C16_07310 ENOG4108VEU Thiamine monophosphate synthase D9C16_07315 ENOG4105ETU transcriptional activator (TenA D9C16_07330 ENOG4105EMS pseudouridine synthase D9C16_07335 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D9C16_07350 ENOG4105MIX Adenylate cyclase D9C16_07355 ENOG4105E4C Lytic transglycosylase catalytic D9C16_07360 ENOG4108Z18 K06886 hemoglobin D9C16_07365 ENOG4105T58 Dithiol-disulfide isomerase D9C16_07380 ENOG4105DPN Oligoendopeptidase f D9C16_07395 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis D9C16_07405 ENOG4108ZCF integral membrane protein D9C16_07410 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) D9C16_07425 ENOG4108JQ7 (ABC) transporter D9C16_07435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D9C16_07440 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D9C16_07445 ENOG4108J59 Extracellular solute-binding protein, family 5 D9C16_07450 ENOG4105C31 Tryptophanyl-tRNA synthetase D9C16_07460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D9C16_07475 ENOG4108JQ7 (ABC) transporter D9C16_07480 ENOG4105C3U ABC transporter D9C16_07490 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D9C16_07495 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D9C16_07510 ENOG4107RMD Basic membrane lipoprotein D9C16_07540 ENOG4105DBV ornithine carbamoyltransferase D9C16_07550 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D9C16_07555 ENOG4105C8Y Acetylornithine aminotransferase D9C16_07570 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D9C16_07590 ENOG4105VG1 fes assembly suf system protein D9C16_07595 ENOG4108MXZ Esterase D9C16_07600 ENOG4108KP7 hydrolase D9C16_07605 ENOG41073B9 D9C16_07615 ENOG4107AYK membrAne D9C16_07620 ENOG4105EPR degv family D9C16_07625 ENOG410751J D9C16_07630 ENOG4105QNR S1 RNA binding domain protein D9C16_07635 ENOG4108VPT UPF0234 protein D9C16_07645 ENOG4105MA6 gCN5-related N-acetyltransferase D9C16_07655 ENOG4107S9D Alpha beta hydrolase D9C16_07660 ENOG4105MYW Pentapeptide repeat protein D9C16_07665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D9C16_07670 ENOG4108ZUB Lysine exporter protein (Lyse ygga) D9C16_07675 ENOG4105SF0 DinB family D9C16_07680 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D9C16_07685 ENOG4105ETE Transcriptional regulator (LacI family D9C16_07690 ENOG4106HBX Transcriptional Regulator AraC Family D9C16_07695 ENOG4105UQX Mate efflux family protein D9C16_07705 ENOG4105CAQ asparagine synthetase D9C16_07715 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin D9C16_07725 ENOG4105ERH Fumarylacetoacetate hydrolase D9C16_07775 ENOG4105EYH Exonuclease D9C16_07785 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation D9C16_07800 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding D9C16_07815 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) D9C16_07820 ENOG4106K7D Major facilitator family transporter D9C16_07825 ENOG4108KK1 membrane protein AbrB duplication D9C16_07840 ENOG4105TRI Hydrolase D9C16_07865 ENOG4108INS Transcriptional regulator D9C16_07870 ENOG4107SCK Monooxygenase D9C16_07885 ENOG41060YP D9C16_07890 ENOG4106CAD Protein of unknown function (DUF3311) D9C16_07895 ENOG4105E1V na solute symporter D9C16_07900 ENOG4105X3H Excalibur domain protein D9C16_07905 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D9C16_07910 ENOG4105XVF Competence transcription factor D9C16_07930 ENOG4106YBV Methyl-accepting chemotaxis D9C16_07935 ENOG4107ZYJ bioY protein D9C16_07940 ENOG4107F3J Amp-dependent synthetase and ligase D9C16_07950 ENOG4107TB6 phosphoglycerate mutase D9C16_07955 ENOG4108HUF Transporter D9C16_07965 ENOG4105KD7 acetyltransferase D9C16_07975 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 D9C16_07985 ENOG4105CEY Amp-dependent synthetase and ligase D9C16_07995 ENOG4105DF9 Lipoate-protein, ligase D9C16_08000 ENOG4108RQ5 Beta-lactamase domain-containing protein D9C16_08005 ENOG4106AXD D9C16_08020 ENOG4105DER m42 family D9C16_08030 ENOG41090T1 Membrane D9C16_08040 ENOG4105ECB domain protein D9C16_08050 ENOG4105C1Q protoporphyrinogen oxidase D9C16_08055 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) D9C16_08060 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D9C16_08065 ENOG4105BZ4 penicillin-binding protein D9C16_08070 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation D9C16_08105 ENOG4105K59 histidine triad (HIT) protein D9C16_08110 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) D9C16_08115 ENOG4105NBU tryptophan transport protein D9C16_08160 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) D9C16_08170 ENOG4105EQI Metal Dependent Phosphohydrolase D9C16_08175 ENOG4106D4I domain protein D9C16_08180 ENOG4107VRP DNA repair exonuclease D9C16_08185 ENOG4105RHA ABC transporter, permease D9C16_08190 ENOG4108IUX (ABC) transporter D9C16_08200 ENOG4105CGU Enoyl-CoA hydratase D9C16_08210 ENOG4105NCW Trka-c domain protein D9C16_08215 ENOG4107S91 Sodium hydrogen exchanger D9C16_08220 ENOG4105D4P Coproporphyrinogen iii oxidase D9C16_08235 ENOG4105WZB UPF0342 protein D9C16_08240 ENOG4106MP8 UPF0754 membrane protein D9C16_08250 ENOG410839P D9C16_08280 ENOG4105BZ1 (ABC) transporter D9C16_08285 ENOG4105BZ1 (ABC) transporter D9C16_08305 ENOG4105F0I Aminotransferase D9C16_08310 ENOG4107VMI polysaccharide deacetylase D9C16_08315 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D9C16_08320 ENOG4105D64 Mechanosensitive ion channel D9C16_08330 ENOG4108QXE glycerophosphoryl diester phosphodiesterase D9C16_08335 ENOG4105WMR Protein CrcB homolog D9C16_08345 ENOG4105C37 (CBS) domain D9C16_08360 ENOG4105C37 (CBS) domain D9C16_08365 ENOG4105F6E Acyl-transferase D9C16_08370 ENOG4108FN7 Aldo keto reductase D9C16_08375 ENOG4108AEY RNA polymerase sigma factor D9C16_08380 ENOG4105J37 D9C16_08395 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D9C16_08400 ENOG4105C8J )-transporter D9C16_08405 ENOG4105CUB amino acid D9C16_08410 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D9C16_08415 ENOG4105BZN citrate synthase D9C16_08430 ENOG4105G6Z alkaline phosphatase D9C16_08435 ENOG4105ED1 spovr family D9C16_08470 ENOG4105WH1 Two component transcriptional regulator luxr family D9C16_08475 ENOG4105BZU Histidine kinase D9C16_08485 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D9C16_08490 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D9C16_08500 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator D9C16_08505 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D9C16_08510 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D9C16_08515 ENOG4107YBY Hydrolase D9C16_08520 ENOG41080XP Cbs domain D9C16_08530 ENOG4108YBP pseudouridine synthase D9C16_08585 ENOG4105K4H Nlp p60 protein D9C16_08595 ENOG4105P1M Domain of unknown function (DUF1874) D9C16_08640 ENOG4106128 DNA-binding helix-turn-helix protein D9C16_08645 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) D9C16_08680 ENOG4105BZU Histidine kinase D9C16_08695 ENOG4105VEQ Cold shock protein D9C16_08700 ENOG4108TU7 Inherit from COG: (ABC) transporter D9C16_08705 ENOG4105CJ1 ABC, transporter D9C16_08710 ENOG4105CZV ABC transporter D9C16_08715 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family D9C16_08735 ENOG4105CS1 NAD(P)H quinone oxidoreductase D9C16_08740 ENOG4105C0R drug resistance transporter emrb qaca subfamily D9C16_08745 ENOG4105CW7 secretion protein, HlyD family D9C16_08750 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes D9C16_08755 ENOG4106AKX UPF0229 protein D9C16_08760 ENOG4105CYN Serine protein kinase D9C16_08780 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) D9C16_08790 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D9C16_08805 ENOG4105VZ8 Transcriptional regulator D9C16_08810 ENOG4107D63 D9C16_08815 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D9C16_08825 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) D9C16_08830 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D9C16_08835 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein D9C16_08840 ENOG4105E2Y ABC, transporter D9C16_08860 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) D9C16_08880 ENOG4108N23 SpoOM-related protein D9C16_08990 ENOG4105G5W regulator Fur family D9C16_08995 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D9C16_09005 ENOG4107NBY Membrane D9C16_09010 ENOG4105BZ1 (ABC) transporter D9C16_09015 ENOG4105EVI UPF0374 protein D9C16_09030 ENOG4105CAN Short-chain dehydrogenase reductase Sdr D9C16_09035 ENOG4106BXE D9C16_09040 ENOG4105CEN a g-specific adenine glycosylase D9C16_09045 ENOG41067AE Membrane-bound metal-dependent hydrolase D9C16_09050 ENOG4105EJV Membrane D9C16_09055 ENOG4105CKK Glycosyl transferase, family 2 D9C16_09060 ENOG4105D74 hydrolase D9C16_09065 ENOG4106AKJ D9C16_09085 ENOG4105F27 Major Facilitator D9C16_09100 ENOG4105ECP epimerase D9C16_09115 ENOG4107Y03 Nitroreductase D9C16_09125 ENOG4108IHU transport system permease protein D9C16_09130 ENOG4105DQ5 transport system permease protein D9C16_09135 ENOG4108MES Periplasmic binding protein D9C16_09145 ENOG410834F Transcriptional regulator D9C16_09155 ENOG4108YYS metal-dependent hydrolase (By similarity) D9C16_09160 ENOG4107Y80 Major Facilitator superfamily D9C16_09165 ENOG4105YA8 Transcriptional regulator D9C16_09170 ENOG4105H93 Acyltransferase family D9C16_09175 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold D9C16_09180 ENOG4105U3E Transcriptional regulator D9C16_09185 ENOG4108KYE ABC-2 type transporter D9C16_09190 ENOG41090VJ ABC-2 type transporter D9C16_09195 ENOG4105CJ1 ABC, transporter D9C16_09200 ENOG4105WH1 Two component transcriptional regulator luxr family D9C16_09205 ENOG4105BZU Histidine kinase D9C16_09215 ENOG4107QP6 Xylose isomerase domain protein TIM barrel D9C16_09220 ENOG4107QNK )-transporter D9C16_09225 ENOG4105ID8 Transcriptional regulator, ARAC family D9C16_09230 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase D9C16_09240 ENOG4105BZ1 (ABC) transporter D9C16_09245 ENOG4105BZ1 (ABC) transporter D9C16_09255 ENOG4105CI1 PTS System D9C16_09260 ENOG4108Q3X Transcriptional regulator D9C16_09265 ENOG4105F8D glycoside hydrolase family 4 D9C16_09295 ENOG4105KK4 UPF0060 membrane protein D9C16_09300 ENOG41069DP small acid-soluble spore protein D9C16_09305 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family D9C16_09315 ENOG4107QKR Dehydrogenase D9C16_09325 ENOG4107RUY (E1 component), alpha subunit D9C16_09350 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D9C16_09360 ENOG4105D7N magnesium and cobalt transport protein CorA D9C16_09365 ENOG4106KE4 Dehydrogenase D9C16_09385 ENOG4105D8X mechanosensitive ion channel D9C16_09395 ENOG4105UPD Calcium Proton D9C16_09400 ENOG4108ISG Major Facilitator D9C16_09405 ENOG4107U9T Pfam:Ribonuclease_BN D9C16_09415 ENOG4105KJF protein tyrosine phosphatase D9C16_09435 ENOG4107RKG DJ-1/PfpI family D9C16_09440 ENOG4105CGH 5'-nucleotidase D9C16_09445 ENOG4108RCM Nitroreductase D9C16_09450 ENOG4107414 GntR family transcriptional regulator D9C16_09455 ENOG4105CG3 alpha amylase, catalytic region D9C16_09460 ENOG4105C5Y PTS System D9C16_09465 ENOG4105E1K spore germination protein D9C16_09505 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) D9C16_09525 ENOG4108RPX mosc domain containing protein D9C16_09530 ENOG410855V Acylphosphatase D9C16_09555 ENOG4108MRH transcriptional regulatory protein D9C16_09565 ENOG4107QPK )-transporter D9C16_09570 ENOG4108J20 pectate lyase D9C16_09580 ENOG4105FDU atp-dependent rna helicase D9C16_09585 ENOG4105C5H ABC transporter D9C16_09605 ENOG4105DXB Major Facilitator superfamily D9C16_09610 ENOG4107SWG transcriptional regulator MERR family D9C16_09620 ENOG4105C5H ABC transporter D9C16_09625 ENOG4105FKZ Methyl-accepting chemotaxis D9C16_09630 ENOG4105C26 Dehydrogenase D9C16_09635 ENOG4105CUB amino acid D9C16_09645 ENOG4105EU0 Major facilitator Superfamily D9C16_09650 ENOG41090R9 glycosyltransferase D9C16_09655 ENOG4107R51 Glycosyl transferase, family 2 D9C16_09660 ENOG41090R9 glycosyltransferase D9C16_09670 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase D9C16_09675 ENOG4105E0M Sulfatase D9C16_09685 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D9C16_09690 ENOG4108R1P D9C16_09710 ENOG41061H0 Monooxygenase D9C16_09715 ENOG4106I4J membrane D9C16_09735 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily D9C16_09740 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) D9C16_09745 ENOG4105H67 Protein of unknown function (DUF421) D9C16_09750 ENOG4105F8D glycoside hydrolase family 4 D9C16_09755 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component D9C16_09765 ENOG4105E0S extracellular solute-binding protein family 1 D9C16_09780 ENOG4107TDE lipolytic protein G-D-S-L family D9C16_09785 ENOG4105CX8 fg-gap repeat protein D9C16_09790 ENOG4105CX8 fg-gap repeat protein D9C16_09805 ENOG4107TDE lipolytic protein G-D-S-L family D9C16_09810 ENOG41075H3 AraC family transcriptional regulator D9C16_09815 ENOG4105F5H Glycosyl Hydrolase Family 88 D9C16_09820 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component D9C16_09825 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component D9C16_09830 ENOG410769Z extracellular solute-binding protein family 1 D9C16_09840 ENOG4105C2F Histidine kinase D9C16_09855 ENOG4105M18 -acetyltransferase D9C16_09860 ENOG4105WEF catalase D9C16_09875 ENOG4105M4P Tetr family transcriptional regulator D9C16_09885 ENOG4105CDY transcriptional regulatory protein D9C16_09940 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D9C16_09945 ENOG4105CBD Diacylglycerol kinase D9C16_09955 ENOG4108IG5 Transcriptional regulator D9C16_09960 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D9C16_09965 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D9C16_09970 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D9C16_09975 ENOG4105CK7 Sodium proline symporter D9C16_09980 ENOG4105KT7 mgtC SapB transporter D9C16_09985 ENOG4105CRN Aminoglycoside phosphotransferase D9C16_10005 ENOG4105C4R Atp-dependent dna helicase D9C16_10010 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) D9C16_10015 ENOG4105CBC glutamate synthase D9C16_10020 ENOG4105KGF protein, YerC YecD D9C16_10025 ENOG4108R5T secreted protein D9C16_10040 ENOG4105DVH amino acid D9C16_10050 ENOG4105C12 Phosphoribosylglycinamide synthetase D9C16_10055 ENOG4105DC1 bifunctional purine biosynthesis protein purh D9C16_10060 ENOG4108V3E phosphoribosylglycinamide formyltransferase D9C16_10065 ENOG4105CXB phosphoribosylaminoimidazole synthetase D9C16_10075 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii D9C16_10080 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I D9C16_10085 ENOG4105VR9 phosphoribosylformylglycinamidine synthase D9C16_10090 ENOG4105C8V SAICAR synthetase D9C16_10095 ENOG4105C83 adenylosuccinate lyase D9C16_10100 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D9C16_10105 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D9C16_10130 ENOG4105C7N Xanthine uracil vitamin C permease D9C16_10155 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D9C16_10170 ENOG4105C85 amino acid D9C16_10175 ENOG4107STQ Multicopper oxidase D9C16_10185 ENOG4107YUH hydrolase D9C16_10220 ENOG4107QNK )-transporter D9C16_10225 ENOG4108ZMR Ion transport 2 domain-containing protein D9C16_10235 ENOG4108WV1 Pfam:DUF477 D9C16_10240 ENOG4105DQX Zinc finger domain D9C16_10255 ENOG4105CT4 transporter D9C16_10260 ENOG4105CPQ Dehydrogenase D9C16_10265 ENOG4105PGZ NB-ARC domain D9C16_10280 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D9C16_10285 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D9C16_10290 ENOG4108TYN CAAX amino terminal protease family protein D9C16_10305 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D9C16_10310 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D9C16_10315 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) D9C16_10320 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D9C16_10325 ENOG4105C5H ABC transporter D9C16_10335 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D9C16_10340 ENOG410801F ribosomal-protein-alanine acetyltransferase D9C16_10345 ENOG41072GX Peptidase M22 Glycoprotease D9C16_10350 ENOG4105K8N protein family UPF0079, ATPase D9C16_10355 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D9C16_10400 ENOG4105D3P Mannan endo-1,4-beta-mannosidase D9C16_10410 ENOG4105EVU fructokinase D9C16_10415 ENOG4108TZY GntR Family Transcriptional Regulator D9C16_10420 ENOG4105CS2 ec 3.2.1.21 D9C16_10435 ENOG4105VZJ PTS System D9C16_10440 ENOG4105F27 Major Facilitator D9C16_10445 ENOG41090UD (LipO)protein D9C16_10450 ENOG4107TVP HD domain protein D9C16_10455 ENOG4108YM7 Gcn5-related n-acetyltransferase D9C16_10465 ENOG4108ZMX Domain of unknown function (DU1801) D9C16_10470 ENOG4105G6Z alkaline phosphatase D9C16_10485 ENOG4105VRS hydrolase family 18 D9C16_10490 ENOG4105DRR Transcriptional regulator, GntR family D9C16_10500 ENOG4105C2C drug resistance transporter, Bcr CflA D9C16_10505 ENOG4105FS7 Transcriptional regulator D9C16_10510 ENOG4108TVJ Nitroreductase D9C16_10515 ENOG4105EYF MMPL domain protein D9C16_10520 ENOG41062A4 Transcriptional regulator D9C16_10530 ENOG4105C85 amino acid D9C16_10540 ENOG4105WQG acetyltransferase D9C16_10550 ENOG4105PF9 Transcriptional regulator D9C16_10570 ENOG4108QY0 Membrane D9C16_10595 ENOG4105XXY Thioredoxin D9C16_10600 ENOG4108VGI doxx family D9C16_10605 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase D9C16_10610 ENOG4108TVJ Nitroreductase D9C16_10615 ENOG41076HS cation diffusion facilitator family transporter D9C16_10620 ENOG4108Z5V transcriptional regulator, merr family D9C16_10625 ENOG4108UQV Membrane D9C16_10630 ENOG4108WC5 Alpha Beta Hydrolase Fold protein D9C16_10635 ENOG4105EYF MMPL domain protein D9C16_10640 ENOG4108VB1 regulatoR D9C16_10645 ENOG4105ENE Histidine kinase D9C16_10660 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D9C16_10665 ENOG4108ZHR arsR family transcriptional regulator D9C16_10670 ENOG4108SQ9 flavin reductase domain protein, FMN-binding D9C16_10675 ENOG4105DY8 decarboxylase D9C16_10685 ENOG4107Y9U Membrane D9C16_10690 ENOG4105Z7P Acetyltransferase (GNAT) family D9C16_10700 ENOG4107R5R arsenical pump membrane protein D9C16_10705 ENOG41082YX Transcriptional regulator, arsr family D9C16_10720 ENOG4105MJ9 esterase D9C16_10725 ENOG4108ZMQ domain protein D9C16_10730 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D9C16_10735 ENOG4105T38 integral membrane protein D9C16_10740 ENOG4105ST3 Transcriptional regulator D9C16_10745 ENOG4105KRI phosphocarrier protein (HPr D9C16_10755 ENOG4105GIG D9C16_10760 ENOG4105CZ9 Domain of unknown function (DU1801) D9C16_10775 ENOG4107U9B transcriptional regulator D9C16_10780 ENOG41086D8 Transcriptional regulator D9C16_10790 ENOG4108MCI Transcriptional regulator, ARAC family D9C16_10805 ENOG4108VJ1 Transcriptional regulator (CarD family D9C16_10810 ENOG4105VEQ Cold shock protein D9C16_10815 ENOG4108V4B ThiJ pfpI D9C16_10840 ENOG4105VZ8 Transcriptional regulator D9C16_10850 ENOG4106BHF D9C16_10865 ENOG4107V2S Transcriptional regulator D9C16_10915 ENOG4105K4H Nlp p60 protein D9C16_10930 ENOG4105P1M Domain of unknown function (DUF1874) D9C16_10975 ENOG4106128 DNA-binding helix-turn-helix protein D9C16_10980 ENOG4106BHR ftsk SpoIIIE family protein D9C16_10985 ENOG4108RYM conjugative transposon protein D9C16_11010 ENOG4108IMY Transcriptional regulator D9C16_11015 ENOG41068WC Domain of unknown function (DUF955) D9C16_11020 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) D9C16_11075 ENOG4105RV9 Transcriptional regulator D9C16_11080 ENOG4105M5P UPF0310 protein D9C16_11095 ENOG41064BQ Phosphatase D9C16_11105 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) D9C16_11110 ENOG4105WN5 stage II sporulation protein D9C16_11115 ENOG4107SGM protein serine threonine phosphatase D9C16_11120 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase D9C16_11125 ENOG4105FUA antagonist D9C16_11130 ENOG4107MMM Anti-sigma-factor antagonist D9C16_11135 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) D9C16_11145 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D9C16_11150 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein D9C16_11155 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D9C16_11165 ENOG4105CKV Membrane D9C16_11170 ENOG410905X membrane-flanked domain protein D9C16_11175 ENOG4105C1J atp-dependent rna helicase D9C16_11185 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) D9C16_11190 ENOG4105CPF Cell wall formation (By similarity) D9C16_11195 ENOG4105SZ6 Thioredoxin D9C16_11215 ENOG4105FDT acyl-CoA dehydrogenase D9C16_11230 ENOG4105CJ1 ABC, transporter D9C16_11235 ENOG4106F5Q Membrane D9C16_11240 ENOG4107QJT sodium dicarboxylate symporter D9C16_11245 ENOG4108MRH transcriptional regulatory protein D9C16_11250 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D9C16_11255 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D9C16_11270 ENOG41082W1 Cupin 2, conserved barrel domain protein D9C16_11275 ENOG4105QVS general stress protein D9C16_11280 ENOG4105EU9 D9C16_11285 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) D9C16_11295 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) D9C16_11335 ENOG4105C9U ATP-dependent DNA helicase RecQ D9C16_11345 ENOG4105VCH membrane D9C16_11355 ENOG410606W general stress protein D9C16_11370 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D9C16_11375 ENOG4105HMZ Methyltransferase D9C16_11385 ENOG4105ETD TRANSCRIPTIONal D9C16_11390 ENOG4107QM2 Aldo Keto reductase D9C16_11395 ENOG4107RVG penicillin-binding protein D9C16_11400 ENOG41061CK Antibiotic biosynthesis monooxygenase D9C16_11410 ENOG4105XJB lipolytic protein G-D-S-L family D9C16_11415 ENOG4107258 Transcriptional regulator D9C16_11425 ENOG4105P4J Allophanate hydrolase, subunit 1 D9C16_11430 ENOG4105CFM UPF0317 protein D9C16_11435 ENOG4105C5A transporter D9C16_11440 ENOG4105E7W lamb ycsf family protein D9C16_11465 ENOG4108ZX0 Signal peptidase I D9C16_11470 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D9C16_11495 ENOG4108ZYE Transcriptional regulator D9C16_11500 ENOG4108T5E Copper resistance protein D9C16_11505 ENOG4105KTB nuclear export factor GLE1 D9C16_11510 ENOG4105H9W Short-chain dehydrogenase reductase Sdr D9C16_11520 ENOG4105C26 Dehydrogenase D9C16_11525 ENOG4108JPW Aminotransferase D9C16_11535 ENOG4105YVS arsR family transcriptional regulator D9C16_11540 ENOG41067V3 Antibiotic biosynthesis monooxygenase D9C16_11545 ENOG4108DBC nitroreductase D9C16_11550 ENOG4105R8C Transcriptional regulator D9C16_11570 ENOG4108IPW abc transporter atp-binding protein D9C16_11575 ENOG4105CM4 permease protein D9C16_11580 ENOG4105DHS permease protein D9C16_11585 ENOG4105CFH Aspartokinase D9C16_11610 ENOG4105BZU Histidine kinase D9C16_11615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D9C16_11620 ENOG4107WD8 ABC transporter, permease D9C16_11640 ENOG4105E1K spore germination protein D9C16_11655 ENOG4105DUX Transporter D9C16_11670 ENOG41069ZX D9C16_11675 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D9C16_11680 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D9C16_11685 ENOG4106P55 Transcriptional regulator D9C16_11695 ENOG4105DRP amino acid AbC transporter D9C16_11700 ENOG4105CDA abc transporter atp-binding protein D9C16_11710 ENOG4105W8Z 4'-phosphopantetheinyl transferase D9C16_11720 ENOG4105SX7 Transporter D9C16_11750 ENOG4105CEY Amp-dependent synthetase and ligase D9C16_11755 ENOG4105KVH Transcriptional regulator D9C16_11760 ENOG4108VA3 3-hexulose-6-phosphate synthase D9C16_11765 ENOG41080HJ 6-phospho 3-hexuloisomerase D9C16_11785 ENOG4105CS2 ec 3.2.1.21 D9C16_11800 ENOG4105K56 Transcriptional regulator D9C16_11810 ENOG4105HHM rdd domain containing protein D9C16_11820 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein D9C16_11825 ENOG4105E5Q amino acid AbC transporter D9C16_11840 ENOG4105S7A ErfK ybiS ycfS ynhG family protein D9C16_11860 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D9C16_11865 ENOG4108IFG nitrite reductase, (NAD(P)H) D9C16_11870 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit D9C16_11875 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D9C16_11885 ENOG4105U6C Alpha beta hydrolase fold protein D9C16_11890 ENOG4108PJD permease D9C16_11900 ENOG4107YHD transcriptional regulator D9C16_11905 ENOG4105CK7 Sodium proline symporter D9C16_11910 ENOG4105C26 Dehydrogenase D9C16_11920 ENOG410756H nucleotidyltransferase D9C16_11925 ENOG4105I82 acetyl xylan esterase D9C16_11930 ENOG4105C5Q Transcriptional regulator D9C16_11935 ENOG41089UC methyltransferase, type 11 D9C16_11945 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D9C16_11955 ENOG4105I1F Resistance protein D9C16_11960 ENOG4107RA1 nh(3)-dependent nad( ) synthetase D9C16_11990 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D9C16_12020 ENOG4107SQ8 Glycine betaine D9C16_12025 ENOG4108IJ7 Glycine betaine D9C16_12030 ENOG4108A65 Transcriptional regulator D9C16_12035 ENOG4107XZQ multidrug resistance protein D9C16_12040 ENOG41079KZ Major Facilitator Superfamily D9C16_12055 ENOG4108TTB tellurium resistance protein D9C16_12060 ENOG4107TS3 membrane protein, TerC D9C16_12065 ENOG4106FN3 tellurium resistance protein D9C16_12070 ENOG4106FN3 tellurium resistance protein D9C16_12075 ENOG4108N0M stress protein D9C16_12090 ENOG4105DIK (ABC) transporter D9C16_12095 ENOG4105DSE periplasmic solute binding protein D9C16_12105 ENOG4105H9W Short-chain dehydrogenase reductase Sdr D9C16_12140 ENOG4107SET aldo keto reductase D9C16_12145 ENOG4108SDH ABC, transporter D9C16_12155 ENOG4107Y7X LytTR D9C16_12165 ENOG41060AI SEC-C motif D9C16_12175 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold D9C16_12180 ENOG4107RB3 L-asparaginase D9C16_12185 ENOG4105J7D transcriptional regulator D9C16_12190 ENOG4105C0R drug resistance transporter emrb qaca subfamily D9C16_12195 ENOG4107EPV Aminotransferase class V D9C16_12200 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) D9C16_12205 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D9C16_12210 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D9C16_12215 ENOG4105DGI Alkaline phosphatase D9C16_12225 ENOG4105MUA Resistance protein D9C16_12260 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D9C16_12280 ENOG4105CTX dehydratase D9C16_12285 ENOG41073TP transcriptional regulator D9C16_12290 ENOG4105EQX glucarate dehydratase D9C16_12295 ENOG4105DJB Major Facilitator Superfamily D9C16_12300 ENOG4105C26 Dehydrogenase D9C16_12305 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase D9C16_12325 ENOG4105CSV Glutaminase D9C16_12340 ENOG4108J5H Homocysteine s-methyltransferase D9C16_12345 ENOG4108IQI permease D9C16_12350 ENOG4105CM2 brancheD-chain amino acid aminotransferase D9C16_12360 ENOG4108X79 transcriptional regulator D9C16_12365 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D9C16_12370 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane D9C16_12380 ENOG4105C72 UPF0176 protein D9C16_12405 ENOG4107ZTW SNARE associated Golgi D9C16_12410 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase D9C16_12415 ENOG4108WC5 Alpha Beta Hydrolase Fold protein D9C16_12425 ENOG4108TCS Glutamyl endopeptidase D9C16_12430 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR D9C16_12435 ENOG4105GIG D9C16_12455 ENOG4106AXJ AraC family transcriptional regulator D9C16_12460 ENOG410631K Membrane D9C16_12485 ENOG410645S MarR family Transcriptional regulator D9C16_12500 ENOG4105CXY transporter D9C16_12505 ENOG4107VXM glycerophosphoryl diester phosphodiesterase D9C16_12510 ENOG4107QTZ amino acid D9C16_12520 ENOG4107E6A Cytochrome p-450 D9C16_12525 ENOG4108HWY Beta-lactamase D9C16_12535 ENOG4106DDH Sporulation-specific SASP protein D9C16_12545 ENOG4106K80 D9C16_12555 ENOG4105G0J serine threonine protein kinase D9C16_12575 ENOG4105GPN Uncharacterized conserved protein (DUF2294) D9C16_12595 ENOG4108TWJ NADH dehydrogenase subunit 5 D9C16_12600 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D9C16_12620 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D9C16_12630 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) D9C16_12635 ENOG4107U5W ybbr family D9C16_12640 ENOG4105C8B TIGR00159 family D9C16_12650 ENOG4105EMN RNA polymerase sigma factor D9C16_12680 ENOG4105EWC Purine nucleoside phosphorylase D9C16_12690 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D9C16_12710 ENOG4105D17 glycoside hydrolase, family 3 domain protein D9C16_12715 ENOG4105EHZ conserved protein UCP016719 D9C16_12720 ENOG410874W AraC family transcriptional regulator D9C16_12740 ENOG4108SA1 esterase D9C16_12750 ENOG4105CHH sulfate transporter D9C16_12835 ENOG4108NMV polysaccharide deacetylase D9C16_12850 ENOG4105D1F ATP-binding protein D9C16_12865 ENOG4108I0C methyltransferase D9C16_12875 ENOG4108UJD 30S ribosomal protein S9 D9C16_12880 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D9C16_12885 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D9C16_12890 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) D9C16_12895 ENOG4108JJB ABC transporter D9C16_12900 ENOG4108JJB ABC transporter D9C16_12905 ENOG4108ZT0 50S ribosomal protein l17 D9C16_12910 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D9C16_12915 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D9C16_12920 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D9C16_12930 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D9C16_12940 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D9C16_12950 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D9C16_12960 ENOG4105VPB 50S ribosomal protein L30 D9C16_12965 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D9C16_12970 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) D9C16_12975 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D9C16_12980 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D9C16_12990 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D9C16_13000 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D9C16_13005 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D9C16_13010 ENOG41082SA 50s ribosomal protein l29 D9C16_13015 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D9C16_13020 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D9C16_13025 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D9C16_13030 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D9C16_13035 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D9C16_13040 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D9C16_13045 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D9C16_13050 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D9C16_13055 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) D9C16_13065 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D9C16_13070 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D9C16_13075 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D9C16_13080 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D9C16_13085 ENOG4105XPM ribosomal protein D9C16_13090 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D9C16_13095 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D9C16_13100 ENOG4107Y49 methyltransferase D9C16_13105 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D9C16_13110 ENOG4108VZM 50s ribosomal protein L10 D9C16_13120 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D9C16_13125 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) D9C16_13145 ENOG4105M0M Tetracycline resistance protein D9C16_13150 ENOG4105C2N RNA methyltransferase TrmH family group 3 D9C16_13155 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) D9C16_13165 ENOG4105D7W serine acetyltransferase D9C16_13175 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D9C16_13180 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) D9C16_13185 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) D9C16_13190 ENOG4105CTP PilT protein domain protein D9C16_13195 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) D9C16_13200 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D9C16_13210 ENOG41066A3 ATP guanido phosphotransferase D9C16_13215 ENOG4108Z0C Uvrb UvrC protein D9C16_13300 ENOG4105CRK lysyL-tRNA synthetase D9C16_13305 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D9C16_13315 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D9C16_13320 ENOG4105KRF dihydroneopterin aldolase D9C16_13325 ENOG4105EEI dihydropteroate synthase D9C16_13330 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 D9C16_13335 ENOG4105DDQ anthranilate synthase D9C16_13340 ENOG4105CRQ synthase (Component I) D9C16_13345 ENOG4105C6T cysteine synthase D9C16_13350 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase D9C16_13355 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) D9C16_13365 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D9C16_13370 ENOG4108UGV hypoxanthine phosphoribosyltransferase D9C16_13375 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D9C16_13405 ENOG41060GV RNA binding s1 domain protein D9C16_13420 ENOG4105VYY sporulation protein yabp D9C16_13425 ENOG41082I2 s4 domain protein D9C16_13430 ENOG4108IY2 MazG family D9C16_13440 ENOG4108M14 stage v sporulation protein t D9C16_13445 ENOG4108JA2 transcriptioN-repair coupling factor D9C16_13455 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D9C16_13460 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D9C16_13465 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D9C16_13470 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D9C16_13475 ENOG4105K4W Could be involved in septation (By similarity) D9C16_13480 ENOG4105KME endoribonuclease L-psp D9C16_13485 ENOG4105DFT pur operon repressor D9C16_13490 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) D9C16_13495 ENOG4105XEW small acid-soluble spore protein D9C16_13500 ENOG4105W42 Veg protein D9C16_13505 ENOG4105XFA sporulation peptidase YabG D9C16_13510 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D9C16_13520 ENOG41069ER domain protein D9C16_13525 ENOG4105F8V Hydrolase, tatD family D9C16_13530 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D9C16_13535 ENOG4105KRN Transcriptional regulator, abrb family D9C16_13540 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D9C16_13545 ENOG4105VC4 domain protein D9C16_13550 ENOG41060K3 Methyltransferase D9C16_13555 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) D9C16_13560 ENOG4105MA4 psp1 domain protein D9C16_13565 ENOG4105FA2 dna polymerase iii D9C16_13570 ENOG4105XVJ Protein of unknown function (DUF327) D9C16_13575 ENOG4105X0R protein from nitrogen regulatory protein P-II D9C16_13580 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) D9C16_13585 ENOG4105CXN decarboxylase D9C16_13590 ENOG4105CDW Resistance protein D9C16_13630 ENOG41067KS pro-sigma K processing D9C16_13640 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D9C16_13645 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) D9C16_13650 ENOG4105C6E dna polymerase iii D9C16_13660 ENOG4108Z6B deaminase D9C16_13665 ENOG4105GTG Isochorismatase D9C16_13670 ENOG4105VRS hydrolase family 18 D9C16_13680 ENOG4105ZMH deoxynucleoside kinase D9C16_13690 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D9C16_13695 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) D9C16_13700 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) D9C16_13710 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D9C16_13745 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D9C16_13750 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D9C16_13765 ENOG410848D S4 domain protein YaaA D9C16_13770 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D9C16_13775 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) D9C16_13785 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) D9C16_13800 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D9C16_13805 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D9C16_13810 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) D9C16_13825 ENOG4107QJE Chromosome Partitioning Protein D9C16_13830 ENOG4105FA0 parb-like partition protein D9C16_13835 ENOG4108ZDA Sporulation protein YyaC D9C16_13845 ENOG4105VDK protein, conserved in bacteria D9C16_13850 ENOG4108J2R molybdopterin oxidoreductase D9C16_13855 ENOG4105C3G gtp-binding protein D9C16_13860 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D9C16_13865 ENOG4108UUM single-stranded DNA-binding protein D9C16_13870 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D9C16_13875 ENOG4105CGK Exodeoxyribonuclease III D9C16_13890 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D9C16_13895 ENOG4105D06 uba thif-type nad fad binding protein D9C16_13900 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase D9C16_13910 ENOG4107FCW Abortive infection protein D9C16_13915 ENOG4105C7Z Conserved Protein D9C16_13920 ENOG4105FTQ Dna gyrase D9C16_13925 ENOG4105C7Z Conserved Protein D9C16_13930 ENOG4105NAE bifunctional deaminase-reductase domain protein D9C16_13935 ENOG4105UNS Pfam:DUF419 D9C16_13940 ENOG4108U7W acetyltransferase D9C16_13950 ENOG41082BV acetyltransferase D9C16_13960 ENOG4108U05 Transcriptional regulator D9C16_13975 ENOG4105DDN Pentapeptide repeat-containing protein D9C16_13980 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein D9C16_13990 ENOG41090E6 transcriptional regulator MERR family D9C16_14010 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase D9C16_14015 ENOG4105KVH Transcriptional regulator D9C16_14030 ENOG4108XMW Membrane D9C16_14035 ENOG4105BZR domain protein D9C16_14040 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D9C16_14045 ENOG4105EDW glycosyl transferase, family 39 D9C16_14050 ENOG4105DJ2 Major Facilitator Superfamily D9C16_14070 ENOG4105CDU Replicative dna helicase D9C16_14075 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase D9C16_14105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D9C16_14110 ENOG4105BZU Histidine kinase D9C16_14125 ENOG4105Q2H domain protein D9C16_14130 ENOG4105C0H protease D9C16_14145 ENOG4108JUB Transcriptional regulator D9C16_14150 ENOG41082BM Transcriptional regulator, arsr family D9C16_14175 ENOG4105C8Y Acetylornithine aminotransferase D9C16_14180 ENOG4108IQI permease D9C16_14185 ENOG41066UZ arginase EC 3.5.3.1 D9C16_14195 ENOG410780I phosphoprotein phosphatase activity D9C16_14200 ENOG4105WQG acetyltransferase D9C16_14205 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) D9C16_14225 ENOG4105E2A Dehydrogenase D9C16_14240 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D9C16_14310 ENOG4105ENA helicase D9C16_14325 ENOG4106QJ6 Integrase catalytic subunit D9C16_14330 ENOG4105EN2 IstB domain-containing protein ATP-binding protein D9C16_14345 ENOG4105VN1 Heat shock protein D9C16_14360 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 D9C16_14365 ENOG4108Z15 abc transporter atp-binding protein D9C16_14370 ENOG4106KKU D9C16_14375 ENOG4108S3Y transcriptional regulator D9C16_14390 ENOG4105CS2 ec 3.2.1.21 D9C16_14395 ENOG4108JU3 Alkyl hydroperoxide reductase D9C16_14400 ENOG4105D3R alkyl hydroperoxide reductase D9C16_14405 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D9C16_14410 ENOG4105C6Z Gluconate D9C16_14415 ENOG4105CMG Carbohydrate kinase D9C16_14420 ENOG4105G3Z GntR family transcriptional regulator D9C16_14425 ENOG4105BZW Glycerate kinase D9C16_14435 ENOG41067MG lrgb family D9C16_14445 ENOG41061AU MarR family Transcriptional regulator D9C16_14450 ENOG4107JEE Short-chain dehydrogenase reductase Sdr D9C16_14455 ENOG4105J7D transcriptional regulator D9C16_14525 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D9C16_14555 ENOG4105CPC Aldo Keto reductase D9C16_14580 ENOG4105D7K pfkb domain protein D9C16_14585 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) D9C16_14590 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) D9C16_14600 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D9C16_14605 ENOG4105F0H myo-inositol catabolism protein D9C16_14610 ENOG4107TRN Xylose isomerase domain protein TIM barrel D9C16_14615 ENOG4105D2N Aldolase D9C16_14645 ENOG4108V5C ABC transporter D9C16_14675 ENOG410667J hydrolase D9C16_14680 ENOG4107QHE Choloylglycine hydrolase D9C16_14685 ENOG4105CPU Monooxygenase D9C16_14690 ENOG4108XSB acetyltransferase, (GNAT) family D9C16_14695 ENOG4105EAB amino acid AbC transporter D9C16_14700 ENOG4108HW4 amino acid AbC transporter D9C16_14710 ENOG4105CH2 amidohydrolase D9C16_14720 ENOG4105ENY Ethanolamine utilization protein eutH D9C16_14725 ENOG4108TM9 integral membrane protein D9C16_14730 ENOG4107RHR regulatoR D9C16_14740 ENOG4105D9N nucleoside D9C16_14745 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) D9C16_14760 ENOG4106Z5D Glycoside Hydrolase Family 43 D9C16_14770 ENOG4105M6F mutator MutT protein D9C16_14775 ENOG4108F3G Type I restriction-modification system, R subunit D9C16_14790 ENOG4107EV6 Inherit from COG: YD repeat protein D9C16_14810 ENOG4105C5Y PTS System D9C16_14820 ENOG4107YZX Universal stress protein D9C16_14830 ENOG4107EXU Short-chain dehydrogenase reductase Sdr D9C16_14955 ENOG4107TDE lipolytic protein G-D-S-L family D9C16_14960 ENOG4105C1J atp-dependent rna helicase D9C16_14965 ENOG4105DEU major facilitator superfamily D9C16_14975 ENOG4105CID antiterminator D9C16_14980 ENOG4108RZ2 Glycoside hydrolase family 16 D9C16_14985 ENOG4105D4T Citrate transporter D9C16_14990 ENOG4105CH6 catalase D9C16_15010 ENOG4105DHI Methyltransferase D9C16_15015 ENOG4105CY2 Citrate transporter D9C16_15020 ENOG4105D6N CoA-transferase, subunit a D9C16_15025 ENOG4108IIH CoA-transferase subunit B D9C16_15030 ENOG4105DTD Dehydrogenase D9C16_15055 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) D9C16_15060 ENOG4105WH1 Two component transcriptional regulator luxr family D9C16_15065 ENOG4105BZU Histidine kinase D9C16_15075 ENOG4105CMR udp-glucose 4-epimerase D9C16_15085 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) D9C16_15105 ENOG4107BJW polysaccharide deacetylase D9C16_15120 ENOG4105D2K citrate carrier protein D9C16_15125 ENOG4105C4M (Ubiquinol oxidase) subunit I D9C16_15130 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D9C16_15135 ENOG4108JJ9 ABC, transporter D9C16_15140 ENOG4108JJ8 (ABC) transporter D9C16_15145 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D9C16_15150 ENOG4105ETS cytosine purines uracil thiamine allantoin D9C16_15170 ENOG41069JR D9C16_15175 ENOG4105DA5 (ABC) transporter D9C16_15190 ENOG4105CH6 catalase D9C16_15195 ENOG4108VX5 3-methyladenine DNA glycosylase D9C16_15205 ENOG4105EMD TRANSCRIPTIONal D9C16_15210 ENOG4105VZJ PTS System D9C16_15215 ENOG4105CK1 PTS System D9C16_15220 ENOG4105VCP PTS System D9C16_15225 ENOG4105F8D glycoside hydrolase family 4 D9C16_15230 ENOG4105CM2 brancheD-chain amino acid aminotransferase D9C16_15240 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD D9C16_15250 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein D9C16_15255 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) D9C16_15275 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase D9C16_15290 ENOG4105IIU Aminopeptidase D9C16_15295 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D9C16_15300 ENOG4105GVJ transcriptional regulator D9C16_15310 ENOG4105X1N Glycosyl transferase family 8 D9C16_15330 ENOG4105CK1 PTS System D9C16_15335 ENOG4108YV3 Protein of unknown function (DUF2711) D9C16_15345 ENOG4105DR4 Methyltransferase D9C16_15355 ENOG4105D8G Major Facilitator superfamily D9C16_15360 ENOG41067MG lrgb family D9C16_15365 ENOG4105VAW lrga family D9C16_15370 ENOG4105CMU LysR family (Transcriptional regulator D9C16_15380 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) D9C16_15385 ENOG4107SJW iron permease, FTR1 D9C16_15390 ENOG410650H (LipO)protein D9C16_15395 ENOG4105DBE peroxidase D9C16_15400 ENOG4107ZXU DSBA oxidoreductase D9C16_15425 ENOG4105WH5 Teichoic acid glycosylation protein D9C16_15430 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) D9C16_15440 ENOG4107BMA Transglycosylase associated protein D9C16_15445 ENOG4105E2S oxidase) subunit II D9C16_15450 ENOG4105BZ9 Cytochrome C oxidase, subunit I D9C16_15455 ENOG4105CCU oxidase (Subunit III) D9C16_15460 ENOG41060D1 Quinol oxidase D9C16_15480 ENOG4108DBC nitroreductase D9C16_15490 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin D9C16_15505 ENOG4108QTI )-transporter D9C16_15510 ENOG4105C5Y PTS System D9C16_15525 ENOG4105DWF phosphomethylpyrimidine kinase D9C16_15530 ENOG4108RJ9 Glycosyl transferase, family 2 D9C16_15535 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D9C16_15540 ENOG4105C26 Dehydrogenase D9C16_15580 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D9C16_15585 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD D9C16_15595 ENOG4107TY6 Acylneuraminate cytidylyltransferase D9C16_15600 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG D9C16_15605 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) D9C16_15610 ENOG4105C1B dTDP-glucose 4-6-dehydratase D9C16_15615 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase D9C16_15620 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase D9C16_15630 ENOG4105D82 Glutamate dehydrogenase D9C16_15635 ENOG4105C26 Dehydrogenase D9C16_15650 ENOG4105FCW Major Facilitator superfamily D9C16_15655 ENOG41061WN bacilysin biosynthesis protein D9C16_15660 ENOG4106CHD Bacilysin biosynthesis protein bacB D9C16_15665 ENOG4105CHR reductase D9C16_15670 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase D9C16_15680 ENOG4105CHM Aminotransferase D9C16_15695 ENOG4108IJ2 phosphate acetyltransferase D9C16_15700 ENOG4105DUM transcriptional regulator, lysR family D9C16_15705 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) D9C16_15710 ENOG4108RNG Permease of the drug metabolite transporter D9C16_15715 ENOG4108VCI transcription factor, rsfa family D9C16_15725 ENOG4105DCI Phosphohydrolase D9C16_15735 ENOG41062ES Transcriptional regulator D9C16_15740 ENOG4105C57 major facilitator superfamily D9C16_15750 ENOG4105C22 threonyL-tRNA synthetase D9C16_15755 ENOG41067TZ transcriptional regulator, MarR family D9C16_15760 ENOG41069HH 4-oxalocrotonate tautomerase D9C16_15765 ENOG4108Z4T Peptidase M50 D9C16_15770 ENOG4108XFG YwhD family D9C16_15780 ENOG4105BZ4 penicillin-binding protein D9C16_15785 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) D9C16_15790 ENOG4105CYW agmatinase D9C16_15795 ENOG4108UIN ybak prolyl-trna synthetase associated region D9C16_15805 ENOG4107JM4 Tetratricopeptide repeat D9C16_15855 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E D9C16_15870 ENOG410684U Domain of unknown function (DUF1934) D9C16_15875 ENOG4105C75 arginyL-tRNA synthetase D9C16_15885 ENOG4107V6Q Cyclic nucleotide-binding domain D9C16_15905 ENOG4108IUE nitrate reductase beta subunit D9C16_15910 ENOG4105R3A Nitrate reductase D9C16_15925 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D9C16_15935 ENOG4105NAE bifunctional deaminase-reductase domain protein D9C16_15945 ENOG4105E5J UV damage endonuclease D9C16_15955 ENOG4105DF6 Fe-S oxidoreductase D9C16_15960 ENOG4105C1G acyl-Coa dehydrogenase D9C16_15970 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D9C16_15980 ENOG410812K response regulator receiver protein D9C16_15985 ENOG4105D2N Aldolase D9C16_15990 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway D9C16_15995 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D9C16_16000 ENOG4105CBT Fructose-1,6-bisphosphatase D9C16_16010 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) D9C16_16015 ENOG41082DI 50s ribosomal protein l31 D9C16_16020 ENOG4107104 thymidine kinase D9C16_16025 ENOG4105C6K Malic enzyme D9C16_16030 ENOG4107TT2 Auxin Efflux Carrier D9C16_16040 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase D9C16_16045 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D9C16_16050 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D9C16_16065 ENOG4108ZXQ stage ii sporulation protein r D9C16_16075 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D9C16_16080 ENOG410815N Probably functions as a manganese efflux pump (By similarity) D9C16_16085 ENOG4107WAU Protein tyrosine phosphatase D9C16_16090 ENOG4108YZG isomerase D9C16_16095 ENOG4108UIC UPF0340 protein D9C16_16100 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D9C16_16105 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D9C16_16115 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) D9C16_16135 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D9C16_16140 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D9C16_16145 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D9C16_16150 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D9C16_16160 ENOG4106778 Protein of unknown function (DUF1146) D9C16_16170 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D9C16_16175 ENOG4105JFG SpoIID LytB domain protein D9C16_16190 ENOG4108TF4 von Willebrand factor, type A D9C16_16200 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D9C16_16240 ENOG4108YZ9 Urea amidohydrolase subunit gamma D9C16_16245 ENOG4105KI2 Urea amidohydrolase subunit beta D9C16_16250 ENOG4105CQM Urea amidohydrolase subunit alpha D9C16_16255 ENOG4108Z40 Transcriptional regulator D9C16_16260 ENOG4108RYK Nad-dependent epimerase dehydratase D9C16_16265 ENOG4106BRK D9C16_16270 ENOG4107TXC Transcriptional regulator D9C16_16275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D9C16_16295 ENOG4107TCE N-acetyltransferase D9C16_16300 ENOG4105FRN stage II sporulation protein D9C16_16310 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase D9C16_16320 ENOG4105BZU Histidine kinase D9C16_16325 ENOG4107P26 D9C16_16330 ENOG4105D3W isochorismatase D9C16_16335 ENOG41080V3 Major Facilitator superfamily D9C16_16340 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease D9C16_16345 ENOG4108M26 parallel beta-helix repeat protein D9C16_16350 ENOG4105CZM Major Facilitator D9C16_16355 ENOG4107MII Sugar-specific transcriptional regulator TrmB D9C16_16365 ENOG4105MT0 Sporulation transcriptional regulator spoiiid D9C16_16370 ENOG4105DFF Rod shape-determining protein mreb D9C16_16380 ENOG4105CGA flagellar basal-body rod protein FlgG D9C16_16390 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D9C16_16395 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) D9C16_16425 ENOG4105Z8H single-stranded DNA-binding protein D9C16_16430 ENOG4105E98 transcriptional regulator DeoR family D9C16_16435 ENOG410667J hydrolase D9C16_16445 ENOG4105C0D helicase D9C16_16450 ENOG4105KBK Zinc finger, swim domain protein D9C16_16460 ENOG4105HTX biosynthesis protein D9C16_16465 ENOG4107YJ4 chain length determinant protein D9C16_16470 ENOG4108RB3 Capsular polysaccharide biosynthesis protein D9C16_16475 ENOG4105C6Y Udp-glucose 6-dehydrogenase D9C16_16530 ENOG4107V2S Transcriptional regulator D9C16_16535 ENOG4108WS4 fmn reductase D9C16_16545 ENOG4105FGV Chromate D9C16_16550 ENOG4105CAH Chromate D9C16_16560 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D9C16_16570 ENOG4107XC4 flavin reductase domain protein, FMN-binding D9C16_16585 ENOG4106UIA D9C16_16600 ENOG4107RSM transcriptional regulator D9C16_16610 ENOG4107FQX Alpha-acetolactate decarboxylase D9C16_16615 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D9C16_16630 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D9C16_16635 ENOG4105CNN ABC, transporter D9C16_16640 ENOG4105C2J ABC transporter D9C16_16645 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) D9C16_16650 ENOG4108RVA ribokinase D9C16_16655 ENOG4105ETE Transcriptional regulator (LacI family D9C16_16665 ENOG4105N98 Capsule biosynthesis protein capB D9C16_16675 ENOG4105PNM synthesis protein D9C16_16685 ENOG4105K4H Nlp p60 protein D9C16_16690 ENOG4105J7I hydrolase D9C16_16695 ENOG4108KGH TRANSCRIPTIONal D9C16_16705 ENOG4108NHD germination protein D9C16_16720 ENOG4105DG6 mannose-6-phosphate isomerase D9C16_16730 ENOG4107RZX Teichoic acid biosynthesis protein D9C16_16740 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase D9C16_16745 ENOG4107SJB teichoic acid biosynthesis D9C16_16750 ENOG4107SJB teichoic acid biosynthesis D9C16_16770 ENOG4105EY8 ABC transporter D9C16_16780 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D9C16_16785 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase D9C16_16795 ENOG41086DT Membrane protein of unknown function D9C16_16800 ENOG41067S9 phage shock protein C, PspC D9C16_16805 ENOG4108PY7 D9C16_16820 ENOG4105I03 Flagellin D9C16_16825 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D9C16_16830 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D9C16_16845 ENOG4105MKU Transcriptional regulator D9C16_16865 ENOG4105CN1 protease D9C16_16870 ENOG4105CRP Part of the ABC transporter FtsEX involved in D9C16_16875 ENOG4105CAK Cell division ATP-binding protein ftsE D9C16_16900 ENOG4105MS2 ribosomal subunit Interface protein D9C16_16915 ENOG4105MQ3 flagellar protein FliS D9C16_16920 ENOG4107RT6 flagellar hook-associated D9C16_16925 ENOG41083S7 flagellar protein FlaG D9C16_16930 ENOG4105I03 Flagellin D9C16_16935 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) D9C16_16940 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) D9C16_16945 ENOG4105MKD D9C16_16950 ENOG4105DTJ flagellar hook-associated protein D9C16_16955 ENOG4105E1Q flagellar hook-associated protein D9C16_16970 ENOG4105RU3 D9C16_16975 ENOG41081UC Inherit from COG: Competence protein D9C16_16995 ENOG4105WH1 Two component transcriptional regulator luxr family D9C16_17000 ENOG4105BZU Histidine kinase D9C16_17005 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein D9C16_17010 ENOG4108KGH TRANSCRIPTIONal D9C16_17045 ENOG4108RDQ ABC transporter D9C16_17055 ENOG4105ESV Glycosyl transferase, family 4 D9C16_17060 ENOG4107EF8 Glycosyl transferase (Group 1 D9C16_17075 ENOG4105QZI O-Antigen Polymerase D9C16_17085 ENOG4105C6Y Udp-glucose 6-dehydrogenase D9C16_17090 ENOG4107RA4 Glycosyl transferase (Group 1 D9C16_17095 ENOG4105PSV Polysaccharide Biosynthesis Protein D9C16_17100 ENOG4105D3Q Sugar transferase D9C16_17110 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D9C16_17115 ENOG4105JFG SpoIID LytB domain protein D9C16_17150 ENOG41088CQ domain protein D9C16_17155 ENOG4105FDP GntR family transcriptional regulator D9C16_17160 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D9C16_17165 ENOG4105CE4 GlcNAc 6-P deacetylase D9C16_17170 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) D9C16_17175 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) D9C16_17180 ENOG4105HKU nucleoside recognition domain-containing protein D9C16_17185 ENOG4107XGZ Hydrolase D9C16_17200 ENOG4108E16 pectate lyase D9C16_17210 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) D9C16_17215 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D9C16_17220 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) D9C16_17225 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D9C16_17230 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D9C16_17235 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase D9C16_17240 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D9C16_17245 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D9C16_17255 ENOG4106FGC D9C16_17265 ENOG4105BZ1 (ABC) transporter D9C16_17280 ENOG4105C3M thioredoxin reductase D9C16_17285 ENOG4108Z4K mutator MutT protein D9C16_17290 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D9C16_17295 ENOG4105CHW UPF0052 protein D9C16_17300 ENOG4105CIE May be required for sporulation (By similarity) D9C16_17305 ENOG4105KRI phosphocarrier protein (HPr D9C16_17310 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase D9C16_17325 ENOG4105EWM Histidine kinase D9C16_17330 ENOG4105C19 ABC transporter D9C16_17345 ENOG4108V2W Carbonate dehydratase D9C16_17350 ENOG4105CHH sulfate transporter D9C16_17360 ENOG4108URH decarboxylase D9C16_17365 ENOG4105FKQ transcriptional regulator D9C16_17370 ENOG4108IUK alpha amylase, catalytic D9C16_17375 ENOG4107FKK extracellular solute-binding protein family 1 D9C16_17380 ENOG4105D56 permease protein D9C16_17385 ENOG4105EG2 ABC transporter, permease D9C16_17400 ENOG4105CG3 alpha amylase, catalytic region D9C16_17405 ENOG4107URF beta-phospho-glucomutase D9C16_17410 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D9C16_17420 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D9C16_17600 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D9C16_17635 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase D9C16_17655 ENOG4105EC2 ftsk spoIIIe D9C16_17690 ENOG4107QTZ amino acid D9C16_17695 ENOG4108HKT sucrose-6-phosphate hydrolase D9C16_17700 ENOG4105EDQ levansucrase EC 2.4.1.10 D9C16_17715 ENOG4105NI3 Protein of unknown function (DUF3237) D9C16_17720 ENOG4105NI3 Protein of unknown function (DUF3237) D9C16_17725 ENOG4105PY6 Phenolic acid decarboxylase D9C16_17735 ENOG4105EBR Carboxylesterase D9C16_17745 ENOG4105HTX biosynthesis protein D9C16_17750 ENOG4108QV3 biosynthesis protein D9C16_17760 ENOG4108PQP glycosyl transferase group 1 D9C16_17765 ENOG4105K64 Glycosyl transferase, family 2 D9C16_17770 ENOG4108KMV Glycosyl transferase (Group 1 D9C16_17775 ENOG41068W6 Capsular polysaccharide biosynthesis protein D9C16_17780 ENOG4107QRS glycosyltransferase group 2 family protein D9C16_17790 ENOG4105K64 Glycosyl transferase, family 2 D9C16_17800 ENOG4105D3Q Sugar transferase D9C16_17805 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family D9C16_17810 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D9C16_17815 ENOG4108ZPC Polysaccharide pyruvyl transferase D9C16_17825 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9C16_17830 ENOG4105DAA L-lactate D9C16_17835 ENOG4105JXH GntR family transcriptional regulator D9C16_17845 ENOG4107FKK extracellular solute-binding protein family 1 D9C16_17855 ENOG4105EG2 ABC transporter, permease D9C16_17870 ENOG4108MJI response regulator D9C16_17875 ENOG4107R6F Alpha Beta Hydrolase Fold protein D9C16_17895 ENOG4108M15 ABC transporter D9C16_17900 ENOG4105KCT ABC transporter D9C16_17905 ENOG4105BZU Histidine kinase D9C16_17915 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D9C16_17920 ENOG4107QR9 Iron-sulfur cluster binding protein D9C16_17925 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) D9C16_17940 ENOG4107RT3 EamA-like transporter family D9C16_17945 ENOG4105GZI Transcriptional regulator D9C16_17955 ENOG4105DEN Luciferase family D9C16_17960 ENOG4105CMD Transcriptional regulator, GntR family D9C16_17975 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D9C16_17980 ENOG4105BZA Phosphoglycerate kinase D9C16_17985 ENOG4105CP7 Triose-phosphate isomerase D9C16_17990 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D9C16_17995 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D9C16_18000 ENOG4108W0I acetyltransferase D9C16_18005 ENOG4105T65 Membrane-associated protein D9C16_18015 ENOG4108QCI YvbH-like oligomerisation region D9C16_18020 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein D9C16_18025 ENOG4107HG4 Transcriptional regulator D9C16_18030 ENOG4108IJ8 ABC transporter D9C16_18035 ENOG4105E90 ABC transporter D9C16_18040 ENOG4108HQR Glycine betaine D9C16_18045 ENOG4105R40 Glycine betaine carnitine choline D9C16_18050 ENOG4107HG4 Transcriptional regulator D9C16_18055 ENOG4108IJ8 ABC transporter D9C16_18060 ENOG4105E90 ABC transporter D9C16_18065 ENOG4108HQR Glycine betaine D9C16_18070 ENOG4105R40 Glycine betaine carnitine choline D9C16_18075 ENOG4105C8Q Methyl-accepting chemotaxis D9C16_18080 ENOG4105KVH Transcriptional regulator D9C16_18105 ENOG4105XZU Preprotein translocase, subunit SecG D9C16_18115 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D9C16_18120 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D9C16_18345 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase D9C16_18355 ENOG41068G1 D9C16_18375 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase D9C16_18400 ENOG4105EWI Short-chain dehydrogenase reductase Sdr D9C16_18405 ENOG4105KBX Transcriptional regulator, TetR family D9C16_18410 ENOG4105KPY Small multidrug resistance protein D9C16_18420 ENOG4105ME7 Membrane D9C16_18435 ENOG4105D9R oxidoreductase D9C16_18440 ENOG4105VPX protein, conserved in bacteria D9C16_18445 ENOG410681U heavy metal transport detoxification protein D9C16_18450 ENOG4105C59 p-type ATPase D9C16_18455 ENOG4105C59 p-type ATPase D9C16_18460 ENOG4107ZQN disulfide bond D9C16_18470 ENOG4105EN6 Membrane D9C16_18480 ENOG4105EEM helicase D9C16_18485 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D9C16_18490 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) D9C16_18495 ENOG4105EEQ Na H antiporter D9C16_18510 ENOG4105E0C molybdate abc transporter D9C16_18515 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D9C16_18520 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family D9C16_18525 ENOG4107QZ2 Sulfatase D9C16_18530 ENOG4107K5X Membrane-bound metal-dependent hydrolase D9C16_18545 ENOG4105D5Q Arginine ornithine antiporter D9C16_18560 ENOG4105DQ5 transport system permease protein D9C16_18570 ENOG4105E0A ABC, transporter D9C16_18575 ENOG4108WMK Efflux transporter RND family MFP subunit D9C16_18580 ENOG4105C19 ABC transporter D9C16_18585 ENOG4107RBB ABC transporter, permease D9C16_18595 ENOG4105F0F Oxalate decarboxylase D9C16_18615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D9C16_18625 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein D9C16_18630 ENOG4105EWI Short-chain dehydrogenase reductase Sdr D9C16_18635 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D9C16_18640 ENOG4105EHG Permease protein D9C16_18645 ENOG4105E0A ABC, transporter D9C16_18650 ENOG4108WBT adenosyltransferase D9C16_18665 ENOG41087YS Phage shock protein A D9C16_18680 ENOG4105ENE Histidine kinase D9C16_18685 ENOG4105WH1 Two component transcriptional regulator luxr family D9C16_18710 ENOG4105C9Q fumarate hydratase class II D9C16_18715 ENOG41067SE Tetr family transcriptional regulator D9C16_18725 ENOG4105F3H Histidine kinase D9C16_18735 ENOG4105C0H protease D9C16_18740 ENOG4105HUF DNA protection during starvation protein D9C16_18810 ENOG4105E0A ABC, transporter D9C16_18820 ENOG4105EGI Transcriptional regulator D9C16_18830 ENOG4105MDS 4-oxalocrotonate tautomerase D9C16_18835 ENOG4105C0R drug resistance transporter emrb qaca subfamily D9C16_18840 ENOG41067TZ transcriptional regulator, MarR family D9C16_18870 ENOG4105CHU acetyl-coa acetyltransferase D9C16_18875 ENOG4105C1G acyl-Coa dehydrogenase D9C16_18880 ENOG41080E8 Transcriptional regulator, Spx MgsR family D9C16_18885 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D9C16_18910 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D9C16_18915 ENOG4108UMI ABC transporter, permease D9C16_18920 ENOG4105D01 (LipO)protein D9C16_18940 ENOG4105C3K feS assembly ATPase SufC D9C16_18945 ENOG4105JRK feS assembly protein SufD D9C16_18950 ENOG4105C9B Cysteine desulfurase D9C16_18955 ENOG4108UNV SUF system FeS assembly protein, NifU family D9C16_18960 ENOG4105DIW FeS assembly protein SUFB D9C16_18965 ENOG4105NPE arsR family transcriptional regulator D9C16_18970 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase D9C16_18985 ENOG4107VFR oxidoreductase D9C16_18990 ENOG4105PKS Excinuclease abc c subunit domain protein D9C16_18995 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine D9C16_19005 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component D9C16_19015 ENOG4108KPW sugar kinase D9C16_19020 ENOG4105FDP GntR family transcriptional regulator D9C16_19025 ENOG4108IJ9 (ABC) transporter D9C16_19030 ENOG4108K8S endonuclease I D9C16_19045 ENOG4105C5R Aminotransferase D9C16_19050 ENOG4105XRQ Xanthine dehydrogenase accessory factor D9C16_19065 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding D9C16_19070 ENOG4107YV9 domain protein D9C16_19080 ENOG4105VT2 5-hydroxyisourate hydrolase D9C16_19085 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) D9C16_19100 ENOG4105G9B Transcriptional regulator D9C16_19105 ENOG4105CD3 dihydroorotase D9C16_19115 ENOG4105I3N Conserved Protein D9C16_19125 ENOG4107R8B 5'-nucleotidase D9C16_19130 ENOG4105KZD Domain of unknown function (DUF1805) D9C16_19135 ENOG4108YTE sporulation protein YunB D9C16_19140 ENOG4105FAA peptidase M23 D9C16_19145 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D9C16_19150 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) D9C16_19155 ENOG4105MMD transcriptional regulator D9C16_19165 ENOG4105D4U had-superfamily hydrolase, subfamily iia D9C16_19170 ENOG4108W5N phosphatidylglycerophosphatase a D9C16_19180 ENOG4105D6E homoserine dehydrogenase D9C16_19185 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) D9C16_19190 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) D9C16_19195 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein D9C16_19200 ENOG41083MR nifu domain-containing protein D9C16_19215 ENOG4105ZKE UPF0349 protein D9C16_19230 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D9C16_19235 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D9C16_19345 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 D9C16_19365 ENOG4105CAY ferredoxin--nadp reductase D9C16_19370 ENOG4105CEP NADH dehydrogenase D9C16_19385 ENOG41069ER domain protein D9C16_19395 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D9C16_19415 ENOG4105NIV Esterase D9C16_19420 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase D9C16_19425 ENOG4105E4F Isochorismate synthase D9C16_19430 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase D9C16_19435 ENOG4105WQI isochorismatase D9C16_19440 ENOG4105CEY Amp-dependent synthetase and ligase D9C16_19445 ENOG4105WQT MbtH domain protein D9C16_19455 ENOG4105DCF alanine dehydrogenase D9C16_19460 ENOG4108K8K Transcriptional regulator D9C16_19500 ENOG410904N short-chain dehydrogenase reductase D9C16_19520 ENOG4105C02 permease D9C16_19545 ENOG4105DAP Nicotinate phosphoribosyltransferase D9C16_19550 ENOG4105D58 Diguanylate phosphodiesterase D9C16_19580 ENOG4105BZU Histidine kinase D9C16_19590 ENOG4105KA0 thioesterase Superfamily protein D9C16_19595 ENOG4105KJM monovalent cation h antiporter subunit g D9C16_19605 ENOG4105SC1 monovalent cation H antiporter subunit E D9C16_19610 ENOG4108JPZ Monovalent cation H antiporter subunit D D9C16_19615 ENOG4108ZE9 Monovalent cation H antiporter subunit C D9C16_19620 ENOG4105HC0 Na H antiporter D9C16_19625 ENOG4105D65 subunit l D9C16_19645 ENOG4105UIB (ABC) transporter D9C16_19650 ENOG4108JQ9 ABC transporter D9C16_19655 ENOG4105DIH basic membrane D9C16_19660 ENOG4108MRH transcriptional regulatory protein D9C16_19675 ENOG4105KIR Thiol-disulfide oxidoreductase dcc D9C16_19680 ENOG4105BZ4 penicillin-binding protein D9C16_19700 ENOG4105Y38 Kinase-associated protein B D9C16_19705 ENOG4108HGU Histidine kinase D9C16_19710 ENOG4105C87 Aminotransferase class I and II D9C16_19720 ENOG4108MUZ hydrolase D9C16_19725 ENOG4108ZB6 transcriptional regulator AsnC family D9C16_19730 ENOG4105CHM Aminotransferase D9C16_19740 ENOG4105WG9 Conserved Protein D9C16_19745 ENOG4107QW4 alcohol dehydrogenase D9C16_19755 ENOG4107QYV phosphohexose isomerase D9C16_19770 ENOG4107PBV potassium channel D9C16_19775 ENOG4107PBV potassium channel D9C16_19790 ENOG4105C37 (CBS) domain D9C16_19805 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme D9C16_19830 ENOG4105C8Q Methyl-accepting chemotaxis D9C16_19850 ENOG4105E98 transcriptional regulator DeoR family D9C16_19855 ENOG4105DET Rhamnulokinase D9C16_19860 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) D9C16_19865 ENOG4105DKG l-rhamnose isomerase D9C16_19870 ENOG4105EE0 oxidoreductase D9C16_19880 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D9C16_19900 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D9C16_19905 ENOG4107I77 yiaA/B two helix domain D9C16_19910 ENOG4105CZN Potassium uptake protein D9C16_19925 ENOG4105TRT Transcriptional regulator D9C16_19930 ENOG4105C26 Dehydrogenase D9C16_19935 ENOG4108JB8 alcohol dehydrogenase D9C16_19940 ENOG4108VNY MOSC domain protein D9C16_19945 ENOG4106DF1 D9C16_19955 ENOG4105DZ6 Band 7 protein D9C16_19960 ENOG4105VRR gCN5-related N-acetyltransferase D9C16_19965 ENOG4105N67 Proton-coupled thiamine transporter YuaJ D9C16_20095 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) D9C16_20105 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) D9C16_20120 ENOG4108KS4 Spore coat protein D9C16_20125 ENOG4107SBE Glycosyl transferase (Group 1 D9C16_20140 ENOG4107SBE Glycosyl transferase (Group 1 D9C16_20145 ENOG4108IAJ Nad-dependent epimerase dehydratase D9C16_20170 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) D9C16_20175 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) D9C16_20180 ENOG4108IPT Naphthoate synthase D9C16_20185 ENOG4105CEY Amp-dependent synthetase and ligase D9C16_20190 ENOG4105DTQ mandelate racemase muconate lactonizing D9C16_20195 ENOG4105DSE periplasmic solute binding protein D9C16_20200 ENOG4105DIK (ABC) transporter D9C16_20205 ENOG4105CC5 ABC transporter D9C16_20210 ENOG4105CC5 ABC transporter D9C16_20235 ENOG4108V2W Carbonate dehydratase D9C16_20240 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D9C16_20245 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) D9C16_20260 ENOG4108RMU ferritin dps family protein D9C16_20275 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component D9C16_20285 ENOG4105D2X ABC transporter substrate-binding protein D9C16_20300 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase D9C16_20305 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D9C16_20310 ENOG4105CAQ asparagine synthetase D9C16_20315 ENOG4105C85 amino acid D9C16_20320 ENOG4108Z0R Transferase D9C16_20325 ENOG4105E8V Alpha Beta Hydrolase Fold protein D9C16_20340 ENOG4105N5T Radical SAM Protein D9C16_20355 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family D9C16_20360 ENOG4105DVE abc transporter atp-binding protein D9C16_20375 ENOG4105C19 ABC transporter D9C16_20380 ENOG4107R34 abc transporter permease protein D9C16_20390 ENOG4105EWM Histidine kinase D9C16_20395 ENOG4105C19 ABC transporter D9C16_20405 ENOG4106UBQ D9C16_20410 ENOG410605W Major Facilitator D9C16_20415 ENOG4105BZU Histidine kinase D9C16_20425 ENOG4105C8T Leucyl-tRNA synthetase D9C16_20430 ENOG41085GJ domain protein D9C16_20440 ENOG4105I1K ABC transporter D9C16_20445 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component D9C16_20460 ENOG4105NTD Inherit from COG: Hydrolase D9C16_20470 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D9C16_20490 ENOG4106A3M Cytochrome p-450 D9C16_20500 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component D9C16_20520 ENOG4105F5H Glycosyl Hydrolase Family 88 D9C16_20545 ENOG4105C94 Transporter D9C16_20550 ENOG4105CBX hi0933 family D9C16_20565 ENOG4105YW5 deoR family transcriptional regulator D9C16_20580 ENOG4105C7N Xanthine uracil vitamin C permease D9C16_20585 ENOG4107QSE Dipeptidase D9C16_20590 ENOG4105C6T cysteine synthase D9C16_20595 ENOG4107F58 2'-5' rna ligase D9C16_20610 ENOG4108IUM Glycogen debranching enzyme D9C16_20615 ENOG4108V15 phosphotransferase enzyme family D9C16_20625 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D9C16_20630 ENOG4105C8F Beta-lactamase domain protein D9C16_20635 ENOG4105C6K Malic enzyme D9C16_20650 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ D9C16_20670 ENOG4108VDD TRNA binding domain protein D9C16_20680 ENOG4105DFU Cell wall formation (By similarity) D9C16_20700 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase D9C16_20705 ENOG4105ETE Transcriptional regulator (LacI family D9C16_20710 ENOG4107R0U MotA TolQ exbB proton channel D9C16_20715 ENOG4105ER2 Ompa motb domain protein D9C16_20720 ENOG4105DGU Histone deacetylase D9C16_20725 ENOG4105W87 Cbs domain D9C16_20730 ENOG4105F1V Acetoin utilization protein D9C16_20740 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D9C16_20745 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D9C16_20755 ENOG4105BZU Histidine kinase D9C16_20765 ENOG4105U5Y Transcriptional regulator D9C16_20800 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D9C16_20805 ENOG4105EFZ amidohydrolase D9C16_20810 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D9C16_20815 ENOG4105D07 Signal peptide peptidase, SppA D9C16_20820 ENOG4105VK3 rdd domain containing protein D9C16_20830 ENOG4105KBJ sporulation protein ytfj D9C16_20835 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) D9C16_20850 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D9C16_20855 ENOG4105EPU Molybdenum cofactor synthesis domain protein D9C16_20860 ENOG4105CDH Citrulline--aspartate ligase D9C16_20865 ENOG4105CH7 arginosuccinase D9C16_20880 ENOG4105E8R UPF0173 metal-dependent hydrolase D9C16_20900 ENOG4105SFS phosphoesterase RecJ domain protein D9C16_20905 ENOG4106EVM D9C16_20915 ENOG4105VV2 D9C16_20920 ENOG4105C0B DNA polymerase III (alpha subunit) D9C16_20925 ENOG4105C6K Malic enzyme D9C16_20930 ENOG4108IEY Carboxyl transferase domain D9C16_20940 ENOG4105CTQ phosphohexokinase D9C16_20945 ENOG4105CA9 Pyruvate kinase D9C16_20950 ENOG4105FS0 cytoplasmic membrane protein D9C16_20965 ENOG4105BZN citrate synthase D9C16_20970 ENOG4108HMX isocitrate dehydrogenase (NADP) D9C16_20975 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D9C16_20980 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D9C16_20985 ENOG4105BZU Histidine kinase D9C16_20990 ENOG4105C2M dna polymerase I D9C16_20995 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D9C16_21005 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D9C16_21010 ENOG4105CV8 reductase D9C16_21015 ENOG4105F27 Major Facilitator D9C16_21020 ENOG4105KVH Transcriptional regulator D9C16_21025 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D9C16_21030 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) D9C16_21035 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) D9C16_21055 ENOG4108TDW sporulation protein YtxC D9C16_21060 ENOG4105C22 threonyL-tRNA synthetase D9C16_21065 ENOG4105U0R haloacid dehalogenase-like hydrolase D9C16_21070 ENOG4108HRK Histidine kinase D9C16_21075 ENOG4105DY9 regulatoR D9C16_21085 ENOG41067MG lrgb family D9C16_21095 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D9C16_21100 ENOG4105VJV 50s ribosomal protein L35 D9C16_21105 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D9C16_21110 ENOG410696E Membrane D9C16_21120 ENOG4105CN9 Peptidase m42 family protein D9C16_21135 ENOG4105EF1 ribulokinase D9C16_21140 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase D9C16_21150 ENOG4108MDK Dehydrogenase D9C16_21165 ENOG4105DRS transport system, permease D9C16_21170 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) D9C16_21185 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D9C16_21190 ENOG4105CQB FAD linked oxidase domain protein D9C16_21200 ENOG41067MF small acid-soluble spore protein D9C16_21205 ENOG4108RWN rrna methyltransferase D9C16_21215 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) D9C16_21220 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) D9C16_21225 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D9C16_21240 ENOG4105DCG PHP domain protein D9C16_21245 ENOG4105C98 muts2 protein D9C16_21255 ENOG4105CEY Amp-dependent synthetase and ligase D9C16_21260 ENOG4107Z3H Transcriptional regulator, TetR family D9C16_21265 ENOG41060WC Enoyl-CoA hydratase D9C16_21270 ENOG4105BZJ Electron transfer flavoprotein D9C16_21275 ENOG4105C10 Electron transfer flavoprotein D9C16_21280 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) D9C16_21285 ENOG4105K63 Thioredoxin D9C16_21290 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D9C16_21300 ENOG4105CFH Aspartokinase D9C16_21310 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit D9C16_21320 ENOG4105E33 succinate dehydrogenase D9C16_21330 ENOG4105PFC Transcriptional regulator D9C16_21335 ENOG41067TZ transcriptional regulator, MarR family D9C16_21340 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D9C16_21345 ENOG4108XJQ germination protein D9C16_21350 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) D9C16_21355 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D9C16_21360 ENOG4105M59 Phosphodiesterase, mj0936 family D9C16_21385 ENOG4107SCJ type I restriction enzyme EcoKI subunit R D9C16_21415 ENOG4107KM7 Heat induced stress protein YflT D9C16_21430 ENOG4105C7K acetolactate synthase D9C16_21435 ENOG4108ZP8 Acetolactate synthase small subunit D9C16_21440 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D9C16_21445 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D9C16_21450 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D9C16_21455 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D9C16_21460 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D9C16_21470 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D9C16_21475 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D9C16_21480 ENOG4108IUQ atp-dependent protease D9C16_21485 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D9C16_21490 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D9C16_21500 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D9C16_21510 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D9C16_21520 ENOG4105D52 delta-aminolevulinic acid dehydratase D9C16_21525 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D9C16_21530 ENOG41068KH stage VI sporulation protein D D9C16_21535 ENOG4106AR7 Spore coat protein D9C16_21545 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D9C16_21550 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D9C16_21555 ENOG4106A3R peptidase D9C16_21565 ENOG4108Z03 MAF-like protein D9C16_21570 ENOG4105W5Q DNA repair protein (RadC D9C16_21575 ENOG4105DFF Rod shape-determining protein mreb D9C16_21580 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D9C16_21585 ENOG4105YHC Rod shape-determining protein MreD D9C16_21590 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) D9C16_21595 ENOG4107QMS site-determining protein D9C16_21610 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D9C16_21615 ENOG4105X36 (ribosomal) protein D9C16_21620 ENOG4105K46 50S ribosomal protein l27 D9C16_21635 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D9C16_21640 ENOG41090I5 UPF0735 ACT domain-containing protein D9C16_21645 ENOG4105CQC Prephenate dehydratase D9C16_21660 ENOG4108IYU L-aspartate oxidase D9C16_21665 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D9C16_21670 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) D9C16_21675 ENOG4106678 morphogenetic protein associated with SpoVID D9C16_21685 ENOG4105CDY transcriptional regulatory protein D9C16_21690 ENOG4105BZG amino acid carrier protein D9C16_21715 ENOG4105CK5 oxidoreductase D9C16_21720 ENOG4105IE8 Alpha-ketoglutarate permease D9C16_21730 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D9C16_21735 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D9C16_21740 ENOG41061AI Protein of unknown function (DUF2905) D9C16_21745 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D9C16_21750 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D9C16_21755 ENOG4105VIE preprotein translocase, subunit YajC D9C16_21760 ENOG4105NAP D9C16_21765 ENOG4108QG2 Membrane D9C16_21770 ENOG4105CKP Polysaccharide Biosynthesis Protein D9C16_21780 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D9C16_21785 ENOG4105NCW Trka-c domain protein D9C16_21790 ENOG41067VP Protein of unknown function (DUF1049) D9C16_21795 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D9C16_21800 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) D9C16_21805 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D9C16_21815 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D9C16_21825 ENOG4105CUT histidyl-tRNA synthetase D9C16_21830 ENOG4105C9M aspartyl-trna synthetase D9C16_21840 ENOG4105CUZ uba thif-type nad fad binding protein D9C16_21845 ENOG4105D1H recombination factor protein RarA D9C16_21855 ENOG4105C3J Cysteine desulfurase D9C16_21860 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D9C16_21870 ENOG4105C7H Helicase, RecD TraA family D9C16_21880 ENOG41060CR D9C16_21890 ENOG4105DRP amino acid AbC transporter D9C16_21895 ENOG4105EAD ABC transporter D9C16_21900 ENOG4105CT1 (ABC) transporter D9C16_21905 ENOG4105CDA abc transporter atp-binding protein D9C16_21910 ENOG4105C02 permease D9C16_21915 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D9C16_21920 ENOG4105VBH UPF0297 protein D9C16_21925 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D9C16_21930 ENOG4105VPH UPF0473 protein D9C16_21935 ENOG4105HHA aminodeoxychorismate lyase D9C16_21940 ENOG4108VQJ O-methyltransferase D9C16_21945 ENOG4105XYU peptidase (U32 family) D9C16_21950 ENOG4105CFP Peptidase U32 D9C16_21955 ENOG4105DBI uridine monophosphokinase D9C16_21960 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D9C16_21965 ENOG4107XRG penicillin-binding protein D9C16_21980 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) D9C16_21995 ENOG4105C28 cystathionine D9C16_22015 ENOG4108JB9 formate dehydrogenase D9C16_22020 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) D9C16_22025 ENOG4105TMB Formate nitrite transporter D9C16_22045 ENOG41082JN Transcriptional regulator D9C16_22055 ENOG4105WDR D9C16_22295 ENOG4108UUM single-stranded DNA-binding protein D9C16_22340 ENOG4108J9Q DNA ligase D9C16_22465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)