locus-tag	class	description
H8S71_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8S71_00010	COG0592	DNA-directed DNA polymerase activity
H8S71_00015	COG2501	S4 domain
H8S71_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8S71_00030	COG0187	DNA topoisomerase II activity
H8S71_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8S71_00070	COG0517	IMP dehydrogenase activity
H8S71_00070	COG0516	GMP reductase activity
H8S71_00075	COG1686	Belongs to the peptidase S11 family
H8S71_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H8S71_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H8S71_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8S71_00100	COG1428	Deoxynucleoside kinase
H8S71_00105	COG1428	Deoxynucleoside kinase
H8S71_00110	COG3858	chitin binding
H8S71_00110	COG1388	LysM domain
H8S71_00115	COG1335	isochorismatase
H8S71_00120	COG0590	tRNA wobble adenosine to inosine editing
H8S71_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H8S71_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8S71_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8S71_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
H8S71_00190	COG3853	Toxic anion resistance protein (TelA)
H8S71_00195	COG1982	Orn Lys Arg decarboxylase major
H8S71_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8S71_00205	COG3870	Protein conserved in bacteria
H8S71_00210	COG1728	Protein conserved in bacteria
H8S71_00215	COG0470	DNA polymerase III
H8S71_00220	COG1774	PSP1 C-terminal conserved region
H8S71_00225	COG4467	Involved in initiation control of chromosome replication
H8S71_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H8S71_00235	COG2827	Endonuclease containing a URI domain
H8S71_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H8S71_00245	COG2002	toxin-antitoxin pair type II binding
H8S71_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_00255	COG0084	hydrolase, TatD family'
H8S71_00260	COG3583	domain protein
H8S71_00260	COG3584	3D domain protein
H8S71_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H8S71_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8S71_00280	COG4466	Protein conserved in bacteria
H8S71_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8S71_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8S71_00300	COG0251	oxidation-reduction process
H8S71_00305	COG2088	sporulation resulting in formation of a cellular spore
H8S71_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8S71_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8S71_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8S71_00325	COG0193	aminoacyl-tRNA hydrolase activity
H8S71_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8S71_00340	COG2002	toxin-antitoxin pair type II binding
H8S71_00345	COG2244	polysaccharide biosynthetic process
H8S71_00350	COG3956	TIGRFAM MazG family protein
H8S71_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H8S71_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8S71_00375	COG1098	S1 RNA binding domain
H8S71_00390	COG2208	phosphoserine phosphatase activity
H8S71_00395	COG2304	oxidoreductase activity
H8S71_00400	COG0515	serine threonine protein kinase
H8S71_00405	COG0037	tRNA processing
H8S71_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8S71_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8S71_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8S71_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8S71_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8S71_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8S71_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8S71_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
H8S71_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8S71_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8S71_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8S71_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8S71_00470	COG1396	sequence-specific DNA binding
H8S71_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8S71_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8S71_00560	COG4463	regulation of RNA biosynthetic process
H8S71_00565	COG3880	PFAM UvrB UvrC protein
H8S71_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
H8S71_00575	COG0542	response to heat
H8S71_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8S71_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H8S71_00590	COG4956	integral membrane protein (PIN domain superfamily)
H8S71_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8S71_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8S71_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8S71_00610	COG1045	serine acetyltransferase
H8S71_00615	COG0215	cysteine-tRNA ligase activity
H8S71_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H8S71_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8S71_00630	COG3688	RNA-binding protein containing a PIN domain
H8S71_00635	COG1595	DNA-templated transcription, initiation
H8S71_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8S71_00650	COG0250	Participates in transcription elongation, termination and antitermination
H8S71_00660	COG0081	regulation of translation
H8S71_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8S71_00675	COG2813	Specifically methylates the guanine in position
H8S71_00680	COG0085	RNA polymerase activity
H8S71_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8S71_00690	COG1358	cellular component organization or biogenesis
H8S71_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8S71_00700	COG0049	tRNA binding
H8S71_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8S71_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8S71_00715	COG0596	Alpha beta hydrolase
H8S71_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8S71_00730	COG0088	Forms part of the polypeptide exit tunnel
H8S71_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8S71_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8S71_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8S71_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H8S71_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8S71_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8S71_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8S71_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8S71_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H8S71_00820	COG0200	Binds to the 23S rRNA
H8S71_00825	COG0201	protein transport
H8S71_00830	COG0563	adenylate kinase activity
H8S71_00835	COG0024	Methionine aminopeptidase
H8S71_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8S71_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H8S71_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H8S71_00865	COG0202	RNA polymerase activity
H8S71_00870	COG0203	ribosomal protein L17
H8S71_00875	COG1122	ATPase activity
H8S71_00880	COG1122	ATPase activity
H8S71_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H8S71_00890	COG0101	tRNA pseudouridine synthase activity
H8S71_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H8S71_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8S71_00905	COG2226	methyltransferase
H8S71_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_00920	COG0489	protein tyrosine kinase activity
H8S71_00930	COG2194	sulfuric ester hydrolase activity
H8S71_00935	COG0726	polysaccharide deacetylase
H8S71_01020	COG0659	secondary active sulfate transmembrane transporter activity
H8S71_01025	COG0385	Bile acid
H8S71_01030	COG2819	hydrolase of the alpha beta superfamily
H8S71_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_01050	COG2207	Transcriptional regulator
H8S71_01055	COG3876	Protein conserved in bacteria
H8S71_01060	COG1472	Belongs to the glycosyl hydrolase 3 family
H8S71_01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8S71_01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_01070	COG1263	PTS System
H8S71_01075	COG1737	Transcriptional regulator
H8S71_01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H8S71_01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_01090	COG1683	Conserved Protein
H8S71_01120	COG1595	DNA-templated transcription, initiation
H8S71_01125	COG5662	AntiSigma factor
H8S71_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H8S71_01135	COG4856	YbbR-like protein
H8S71_01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8S71_01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8S71_01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8S71_01160	COG2169	Transcriptional regulator
H8S71_01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H8S71_01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8S71_01175	COG3002	Belongs to the UPF0753 family
H8S71_01180	COG0288	reversible hydration of carbon dioxide
H8S71_01190	COG5609	conserved protein (DUF2294)
H8S71_01195	COG0640	Transcriptional regulator
H8S71_01200	COG2814	Major facilitator Superfamily
H8S71_01210	COG1404	Belongs to the peptidase S8 family
H8S71_01230	COG1132	(ABC) transporter
H8S71_01235	COG0596	Alpha beta hydrolase
H8S71_01240	COG0745	RESPONSE REGULATOR receiver
H8S71_01245	COG0642	Histidine kinase
H8S71_01255	COG0515	serine threonine protein kinase
H8S71_01270	COG1113	amino acid transport
H8S71_01285	COG2602	Beta-lactamase
H8S71_01290	COG2124	cytochrome p450
H8S71_01300	COG0531	amino acid
H8S71_01310	COG0584	glycerophosphoryl diester phosphodiesterase
H8S71_01315	COG2271	Major facilitator Superfamily
H8S71_01325	COG1846	Transcriptional regulator
H8S71_01325	COG0456	acetyltransferase
H8S71_01330	COG2271	Major facilitator Superfamily
H8S71_01335	COG0697	spore germination
H8S71_01340	COG1917	Cupin 2, conserved barrel domain protein
H8S71_01340	COG2207	Transcriptional regulator
H8S71_01345	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8S71_01350	COG3591	Belongs to the peptidase S1B family
H8S71_01360	COG0596	Alpha beta hydrolase
H8S71_01365	COG1183	phosphatidylcholine synthase activity
H8S71_01370	COG0586	Pfam SNARE associated Golgi protein
H8S71_01375	COG0688	phosphatidylethanolamine metabolic process
H8S71_01385	COG2312	Erythromycin esterase
H8S71_01390	COG1054	Belongs to the UPF0176 family
H8S71_01395	COG1301	dicarboxylic acid transport
H8S71_01400	COG1263	PTS System
H8S71_01400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_01400	COG2190	(PTS) system
H8S71_01405	COG0363	glucosamine-6-phosphate deaminase activity
H8S71_01410	COG2188	Transcriptional regulator
H8S71_01420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8S71_01425	COG0833	amino acid
H8S71_01430	COG2040	homocysteine
H8S71_01435	COG1115	amino acid carrier protein
H8S71_01440	COG2066	Belongs to the glutaminase family
H8S71_01445	COG4191	Histidine kinase
H8S71_01450	COG0784	Response regulator, receiver
H8S71_01455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8S71_01460	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_01465	COG2271	Major facilitator Superfamily
H8S71_01470	COG4948	Mandelate Racemase Muconate Lactonizing
H8S71_01475	COG2186	Transcriptional regulator
H8S71_01480	COG2721	sulfolactate sulfo-lyase activity
H8S71_01485	COG3173	Aminoglycoside phosphotransferase
H8S71_01495	COG0697	spore germination
H8S71_01500	COG0745	RESPONSE REGULATOR receiver
H8S71_01505	COG2205	protein histidine kinase activity
H8S71_01510	COG1131	(ABC) transporter
H8S71_01530	COG3773	Cell wall hydrolase
H8S71_01535	COG2304	oxidoreductase activity
H8S71_01545	COG3540	Alkaline phosphatase
H8S71_01550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8S71_01555	COG0805	protein transport
H8S71_01560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H8S71_01565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8S71_01570	COG0477	Major facilitator Superfamily
H8S71_01575	COG1309	transcriptional regulator
H8S71_01580	COG0252	asparaginase activity
H8S71_01585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H8S71_01590	COG1714	RDD family
H8S71_01595	COG3012	SEC-C Motif Domain Protein
H8S71_01595	COG1405	negative regulation of cell septum assembly
H8S71_01600	COG3290	protein histidine kinase activity
H8S71_01605	COG3279	Response regulator of the LytR AlgR family
H8S71_01610	COG4555	ABC transporter
H8S71_01615	COG1668	transmembrane transport
H8S71_01620	COG0667	Aldo Keto reductase
H8S71_01635	COG1595	DNA-templated transcription, initiation
H8S71_01640	COG1595	DNA-templated transcription, initiation
H8S71_01645	COG1876	peptidase activity
H8S71_01650	COG0457	Tetratricopeptide repeat
H8S71_01655	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_01660	COG0366	Alpha amylase catalytic
H8S71_01665	COG0803	Belongs to the bacterial solute-binding protein 9 family
H8S71_01670	COG1121	(ABC) transporter
H8S71_01675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8S71_01680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_01685	COG2310	stress, protein
H8S71_01690	COG2310	stress, protein
H8S71_01695	COG2310	stress, protein
H8S71_01700	COG0861	Integral membrane protein TerC family
H8S71_01710	COG3853	Toxic anion resistance protein (TelA)
H8S71_01715	COG0477	Major facilitator Superfamily
H8S71_01720	COG2814	Major facilitator Superfamily
H8S71_01725	COG0640	Transcriptional regulator
H8S71_01730	COG4175	Glycine betaine
H8S71_01730	COG0517	IMP dehydrogenase activity
H8S71_01735	COG4176	ABC-type proline glycine betaine transport system permease component
H8S71_01740	COG2113	Glycine betaine
H8S71_01745	COG1473	amidohydrolase
H8S71_01750	COG1288	antiporter activity
H8S71_01760	COG0366	Alpha amylase catalytic
H8S71_01765	COG0039	L-malate dehydrogenase activity
H8S71_01770	COG1620	l-lactate permease
H8S71_01775	COG2814	Major facilitator Superfamily
H8S71_01780	COG1846	Transcriptional regulator
H8S71_01785	COG1280	lysine exporter protein (LysE YggA)
H8S71_01790	COG3403	YqcI/YcgG family
H8S71_01795	COG1113	amino acid transport
H8S71_01800	COG3665	Urea carboxylase-associated protein
H8S71_01805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8S71_01810	COG1660	Displays ATPase and GTPase activities
H8S71_01815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8S71_01820	COG2226	methyltransferase
H8S71_01825	COG0583	DNA-binding transcription factor activity
H8S71_01830	COG3458	cephalosporin-C deacetylase activity
H8S71_01835	COG3541	Predicted nucleotidyltransferase
H8S71_01840	COG0506	proline dehydrogenase activity
H8S71_01845	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_01850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_01855	COG2508	Transcriptional regulator
H8S71_01860	COG3689	TIGRFAM TIGR03943 family protein
H8S71_01865	COG0701	Predicted permease
H8S71_01870	COG2267	carboxylic ester hydrolase activity
H8S71_01875	COG0492	ferredoxin-NADP+ reductase activity
H8S71_01880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8S71_01880	COG1587	Uroporphyrinogen-III synthase
H8S71_01885	COG2146	nitrite reductase [NAD(P)H] activity
H8S71_01890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8S71_01895	COG0243	molybdopterin cofactor binding
H8S71_01900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8S71_01905	COG2223	nitrite transmembrane transporter activity
H8S71_01910	COG1469	GTP cyclohydrolase I activity
H8S71_01915	COG1376	ErfK ybiS ycfS ynhG family protein
H8S71_01925	COG0523	cobalamin synthesis protein
H8S71_01930	COG0765	amino acid transport
H8S71_01935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_01945	COG1714	RDD family
H8S71_01955	COG1846	Transcriptional regulator
H8S71_01965	COG3842	ATPase activity
H8S71_01970	COG2723	6-phospho-beta-galactosidase activity
H8S71_01980	COG3209	COG3209 Rhs family protein
H8S71_01985	COG0840	transmembrane signaling receptor activity
H8S71_01985	COG3290	protein histidine kinase activity
H8S71_01990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H8S71_01995	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H8S71_02000	COG1733	regulation of RNA biosynthetic process
H8S71_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_02020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H8S71_02025	COG2814	Major facilitator Superfamily
H8S71_02035	COG0697	spore germination
H8S71_02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_02050	COG2364	Membrane
H8S71_02055	COG1126	abc transporter atp-binding protein
H8S71_02060	COG0765	amino acid transport
H8S71_02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_02070	COG0583	DNA-binding transcription factor activity
H8S71_02075	COG0163	prenyltransferase activity
H8S71_02080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8S71_02095	COG0596	Alpha beta hydrolase
H8S71_02100	COG3104	oligopeptide transport
H8S71_02105	COG5434	Belongs to the glycosyl hydrolase 28 family
H8S71_02115	COG0697	spore germination
H8S71_02125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H8S71_02130	COG1136	(ABC) transporter
H8S71_02135	COG0577	efflux transmembrane transporter activity
H8S71_02140	COG0745	RESPONSE REGULATOR receiver
H8S71_02145	COG5002	protein histidine kinase activity
H8S71_02145	COG3850	Histidine kinase
H8S71_02150	COG0457	Tetratricopeptide repeat
H8S71_02170	COG0527	aspartate kinase activity
H8S71_02175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_02180	COG4605	iron ion homeostasis
H8S71_02185	COG4604	ABC transporter, ATP-binding protein
H8S71_02190	COG4607	ABC-type enterochelin transport system periplasmic component
H8S71_02195	COG2814	Major facilitator Superfamily
H8S71_02200	COG1309	transcriptional regulator
H8S71_02205	COG0778	Nitroreductase
H8S71_02210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H8S71_02215	COG0640	Transcriptional regulator
H8S71_02220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_02225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H8S71_02230	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_02235	COG4975	Glucose uptake
H8S71_02240	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_02245	COG4549	nuclear export factor GLE1
H8S71_02250	COG1276	copper resistance
H8S71_02250	COG2372	response to copper ion
H8S71_02255	COG1349	DNA-binding transcription factor activity
H8S71_02265	COG2213	PTS system mannitol-specific
H8S71_02270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_02275	COG0246	Mannitol dehydrogenase
H8S71_02280	COG0473	3-isopropylmalate dehydrogenase activity
H8S71_02285	COG0681	Belongs to the peptidase S26 family
H8S71_02290	COG0412	Dienelactone hydrolase
H8S71_02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8S71_02305	COG0561	phosphatase activity
H8S71_02310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H8S71_02315	COG1914	H( )-stimulated, divalent metal cation uptake system
H8S71_02320	COG4336	lyase activity
H8S71_02325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H8S71_02330	COG1984	allophanate hydrolase subunit 2
H8S71_02335	COG1414	Transcriptional regulator
H8S71_02340	COG2755	lipolytic protein G-D-S-L family
H8S71_02350	COG2329	Antibiotic biosynthesis monooxygenase
H8S71_02355	COG0768	penicillin binding
H8S71_02360	COG4989	oxidoreductase activity
H8S71_02365	COG3711	transcriptional antiterminator
H8S71_02370	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_02375	COG2226	methyltransferase
H8S71_02380	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_02385	COG1917	Cupin 2, conserved barrel domain protein
H8S71_02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_02395	COG3871	stress protein (general stress protein 26)
H8S71_02405	COG2814	Major facilitator Superfamily
H8S71_02410	COG1522	sequence-specific DNA binding
H8S71_02415	COG0551	DNA topoisomerase type I activity
H8S71_02415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8S71_02420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8S71_02425	COG3706	GGDEF domain
H8S71_02430	COG5298	Protein conserved in bacteria
H8S71_02435	COG1215	transferase activity, transferring glycosyl groups
H8S71_02445	COG0531	amino acid
H8S71_02450	COG0494	nUDIX hydrolase
H8S71_02455	COG0028	Belongs to the TPP enzyme family
H8S71_02465	COG1914	H( )-stimulated, divalent metal cation uptake system
H8S71_02470	COG2261	transglycosylase associated protein
H8S71_02475	COG4876	unkown
H8S71_02480	COG2217	Heavy metal translocating P-type atpase
H8S71_02485	COG3729	General stress protein
H8S71_02490	COG0662	Cupin 2, conserved barrel domain protein
H8S71_02500	COG3546	catalase activity
H8S71_02505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8S71_02510	COG3290	protein histidine kinase activity
H8S71_02515	COG4565	transcriptional regulatory protein
H8S71_02520	COG1301	dicarboxylic acid transport
H8S71_02525	COG0628	permease
H8S71_02530	COG1131	(ABC) transporter
H8S71_02535	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H8S71_02545	COG1960	acyl-CoA dehydrogenase activity
H8S71_02560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8S71_02565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_02570	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8S71_02575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8S71_02580	COG0513	Belongs to the DEAD box helicase family
H8S71_02585	COG3402	PFAM membrane-flanked domain
H8S71_02590	COG3428	Bacterial PH domain
H8S71_02595	COG0705	Rhomboid family
H8S71_02600	COG0736	holo-[acyl-carrier-protein] synthase activity
H8S71_02605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8S71_02610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8S71_02615	COG0864	Transcriptional regulator
H8S71_02620	COG2337	Toxic component of a toxin-antitoxin (TA) module
H8S71_02625	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_02630	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_02635	COG2172	sigma factor antagonist activity
H8S71_02640	COG2208	phosphoserine phosphatase activity
H8S71_02645	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_02650	COG2172	sigma factor antagonist activity
H8S71_02655	COG1191	sigma factor activity
H8S71_02660	COG2208	phosphoserine phosphatase activity
H8S71_02670	COG1673	EVE domain
H8S71_02675	COG1846	Transcriptional regulator
H8S71_02680	COG2183	response to ionizing radiation
H8S71_02690	COG3091	SprT-like family
H8S71_02750	COG1476	TRANSCRIPTIONal
H8S71_02775	COG0693	protein deglycase activity
H8S71_02780	COG1278	Cold shock
H8S71_02785	COG1329	Transcriptional regulator
H8S71_02790	COG0697	spore germination
H8S71_02795	COG2207	Transcriptional regulator
H8S71_02795	COG1917	Cupin 2, conserved barrel domain protein
H8S71_02800	COG0697	spore germination
H8S71_02805	COG3708	Transcriptional regulator
H8S71_02805	COG2207	Transcriptional regulator
H8S71_02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_02815	COG0477	Major facilitator Superfamily
H8S71_02825	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
H8S71_02835	COG0697	spore germination
H8S71_02840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_02845	COG2030	dehydratase
H8S71_02850	COG3545	Serine hydrolase
H8S71_02855	COG1733	regulation of RNA biosynthetic process
H8S71_02860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_02865	COG0640	Transcriptional regulator
H8S71_02870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H8S71_02880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_02885	COG1316	TRANSCRIPTIONal
H8S71_02900	COG5002	protein histidine kinase activity
H8S71_02905	COG0745	RESPONSE REGULATOR receiver
H8S71_02910	COG0697	spore germination
H8S71_02915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_02925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8S71_02930	COG0640	Transcriptional regulator
H8S71_02935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8S71_02950	COG4585	Histidine kinase
H8S71_02955	COG2197	response regulator
H8S71_02960	COG2409	Drug exporters of the RND superfamily
H8S71_02965	COG1811	Na channel or pump
H8S71_02970	COG0789	Transcriptional regulator
H8S71_02970	COG4978	Transcriptional regulator
H8S71_02975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8S71_02980	COG0778	Nitroreductase
H8S71_02985	COG0346	lactoylglutathione lyase activity
H8S71_02990	COG2259	Doxx family
H8S71_02995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_03025	COG0071	Belongs to the small heat shock protein (HSP20) family
H8S71_03040	COG1309	transcriptional regulator
H8S71_03050	COG0456	acetyltransferase
H8S71_03055	COG0488	(ABC) transporter
H8S71_03060	COG1113	amino acid transport
H8S71_03065	COG2318	DinB family
H8S71_03070	COG1846	Transcriptional regulator
H8S71_03075	COG2409	Drug exporters of the RND superfamily
H8S71_03075	COG1033	growth of symbiont in host cell
H8S71_03080	COG0778	Nitroreductase
H8S71_03085	COG1846	Transcriptional regulator
H8S71_03090	COG2814	Major facilitator Superfamily
H8S71_03095	COG0730	response to heat
H8S71_03100	COG1802	Transcriptional regulator
H8S71_03105	COG1388	LysM domain
H8S71_03105	COG3858	chitin binding
H8S71_03110	COG1819	glycosyl
H8S71_03120	COG1785	Belongs to the alkaline phosphatase family
H8S71_03125	COG5646	InterPro IPR014922
H8S71_03135	COG0454	-acetyltransferase
H8S71_03140	COG1078	dGTPase activity
H8S71_03145	COG1388	LysM domain
H8S71_03150	COG2814	Major facilitator Superfamily
H8S71_03155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_03160	COG1447	Phosphotransferase system cellobiose-specific component IIA
H8S71_03165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_03170	COG2723	6-phospho-beta-galactosidase activity
H8S71_03175	COG2188	Transcriptional regulator
H8S71_03180	COG1940	carbohydrate kinase activity
H8S71_03185	COG1482	cell wall glycoprotein biosynthetic process
H8S71_03190	COG4124	Belongs to the glycosyl hydrolase 26 family
H8S71_03235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8S71_03240	COG0802	atpase or kinase
H8S71_03245	COG1214	PFAM Peptidase M22, glycoprotease
H8S71_03250	COG0456	acetyltransferase
H8S71_03255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8S71_03260	COG0488	(ABC) transporter
H8S71_03265	COG0315	cyclic pyranopterin monophosphate synthase activity
H8S71_03270	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H8S71_03275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8S71_03280	COG0805	protein transport
H8S71_03290	COG1266	CAAX protease self-immunity
H8S71_03300	COG0459	protein refolding
H8S71_03305	COG1073	alpha beta
H8S71_03310	COG0457	Tetratricopeptide repeat
H8S71_03315	COG1063	alcohol dehydrogenase
H8S71_03320	COG2211	Major facilitator Superfamily
H8S71_03325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_03330	COG1842	Phage shock protein A
H8S71_03335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8S71_03340	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H8S71_03345	COG4260	virion core protein, lumpy skin disease virus
H8S71_03355	COG2814	Major facilitator Superfamily
H8S71_03360	COG1063	alcohol dehydrogenase
H8S71_03365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8S71_03370	COG0823	Involved in the tonB-independent uptake of proteins
H8S71_03385	COG2267	carboxylic ester hydrolase activity
H8S71_03395	COG2132	Multicopper oxidase
H8S71_03400	COG1113	amino acid transport
H8S71_03410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8S71_03415	COG0714	Associated with various cellular activities
H8S71_03420	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
H8S71_03425	COG1305	Transglutaminase-like
H8S71_03430	COG0519	Catalyzes the synthesis of GMP from XMP
H8S71_03430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8S71_03445	COG2252	PERMEase
H8S71_03450	COG3064	Membrane
H8S71_03460	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H8S71_03470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H8S71_03475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H8S71_03480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H8S71_03485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8S71_03490	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8S71_03495	COG0047	phosphoribosylformylglycinamidine synthase activity
H8S71_03500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8S71_03505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H8S71_03510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8S71_03515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8S71_03520	COG0138	bifunctional purine biosynthesis protein purh
H8S71_03525	COG0151	Belongs to the GarS family
H8S71_03530	COG1522	sequence-specific DNA binding
H8S71_03535	COG0531	amino acid
H8S71_03545	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H8S71_03550	COG1470	cell adhesion involved in biofilm formation
H8S71_03555	COG4496	protein, YerC YecD
H8S71_03560	COG0069	glutamate synthase activity
H8S71_03565	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H8S71_03570	COG0210	DNA helicase
H8S71_03575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8S71_03580	COG4851	CamS sex pheromone cAM373 precursor
H8S71_03585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_03590	COG1285	pathogenesis
H8S71_03595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_03600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8S71_03605	COG0154	amidase activity
H8S71_03610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8S71_03615	COG1309	transcriptional regulator
H8S71_03620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8S71_03625	COG1597	lipid kinase activity
H8S71_03630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8S71_03650	COG5444	nuclease activity
H8S71_03655	COG3391	amine dehydrogenase activity
H8S71_03660	COG0457	Tetratricopeptide repeat
H8S71_03670	COG0217	transcriptional regulatory protein
H8S71_03680	COG1309	transcriptional regulator
H8S71_03685	COG3631	Ketosteroid isomerase-related protein
H8S71_03690	COG0702	epimerase
H8S71_03705	COG3546	catalase activity
H8S71_03710	COG0454	-acetyltransferase
H8S71_03720	COG5578	integral membrane protein
H8S71_03725	COG2972	Histidine kinase
H8S71_03730	COG4753	response regulator
H8S71_03730	COG2207	Transcriptional regulator
H8S71_03735	COG1653	transport
H8S71_03740	COG1175	transmembrane transport
H8S71_03745	COG0395	ABC-type sugar transport system, permease component
H8S71_03750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H8S71_03755	COG2207	Transcriptional regulator
H8S71_03760	COG2755	lipolytic protein G-D-S-L family
H8S71_03770	COG5578	integral membrane protein
H8S71_03775	COG3401	FG-GAP repeat protein
H8S71_03780	COG3401	FG-GAP repeat protein
H8S71_03785	COG2755	lipolytic protein G-D-S-L family
H8S71_03790	COG1874	Beta-galactosidase
H8S71_03800	COG1653	transport
H8S71_03805	COG4209	transmembrane transport
H8S71_03810	COG0395	ABC-type sugar transport system, permease component
H8S71_03815	COG1486	melibiose metabolic process
H8S71_03820	COG2323	membrane
H8S71_03825	COG2329	Antibiotic biosynthesis monooxygenase
H8S71_03830	COG0346	lactoylglutathione lyase activity
H8S71_03845	COG5583	Uncharacterized small protein (DUF2292)
H8S71_03850	COG0670	Belongs to the BI1 family
H8S71_03855	COG0697	spore germination
H8S71_03860	COG1846	Transcriptional regulator
H8S71_03865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8S71_03880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8S71_03880	COG2124	cytochrome p450
H8S71_03885	COG1368	sulfuric ester hydrolase activity
H8S71_03890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8S71_03895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8S71_03900	COG1442	glycosyl transferase family 8
H8S71_03905	COG1216	Glycosyl transferase, family 2
H8S71_03910	COG1442	glycosyl transferase family 8
H8S71_03915	COG2223	nitrite transmembrane transporter activity
H8S71_03920	COG1011	Hydrolase
H8S71_03925	COG0531	amino acid
H8S71_03930	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_03935	COG0840	transmembrane signaling receptor activity
H8S71_03940	COG0488	(ABC) transporter
H8S71_03950	COG0789	Transcriptional regulator
H8S71_03955	COG2814	Major facilitator Superfamily
H8S71_03965	COG0488	(ABC) transporter
H8S71_03970	COG0513	Belongs to the DEAD box helicase family
H8S71_03975	COG0456	acetyltransferase
H8S71_03980	COG2130	NADP-dependent
H8S71_03985	COG2211	Major facilitator Superfamily
H8S71_03990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8S71_03995	COG1120	ATPase activity
H8S71_04000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_04010	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H8S71_04025	COG3866	Pectate lyase
H8S71_04030	COG0471	metal ion transport
H8S71_04035	COG3290	protein histidine kinase activity
H8S71_04040	COG4565	transcriptional regulatory protein
H8S71_04045	COG3181	Tripartite tricarboxylate transporter family receptor
H8S71_04050	COG2851	Citrate transporter
H8S71_04055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_04060	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H8S71_04065	COG1254	Belongs to the acylphosphatase family
H8S71_04070	COG2258	MOSC domain
H8S71_04090	COG0024	Methionine aminopeptidase
H8S71_04095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_04095	COG1263	PTS System
H8S71_04100	COG1368	sulfuric ester hydrolase activity
H8S71_04115	COG1115	amino acid carrier protein
H8S71_04120	COG0531	amino acid
H8S71_04135	COG0697	spore germination
H8S71_04140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_04140	COG1263	PTS System
H8S71_04145	COG0366	Alpha amylase catalytic
H8S71_04150	COG2188	Transcriptional regulator
H8S71_04155	COG0778	Nitroreductase
H8S71_04160	COG0737	Belongs to the 5'-nucleotidase family
H8S71_04165	COG0693	protein deglycase activity
H8S71_04170	COG2814	Major facilitator Superfamily
H8S71_04175	COG4840	Belongs to the UPF0435 family
H8S71_04180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8S71_04185	COG4980	gas vesicle protein
H8S71_04190	COG1295	ribonuclease BN
H8S71_04195	COG0477	Major facilitator Superfamily
H8S71_04200	COG0387	Pfam Sodium calcium exchanger
H8S71_04210	COG0668	transmembrane transport
H8S71_04215	COG0535	radical SAM domain protein
H8S71_04225	COG0726	polysaccharide deacetylase
H8S71_04230	COG2084	Dehydrogenase
H8S71_04235	COG0598	Magnesium transport protein CorA
H8S71_04240	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8S71_04245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8S71_04255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8S71_04260	COG4637	Psort location Cytoplasmic, score
H8S71_04270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8S71_04275	COG0022	dehydrogenase e1 component
H8S71_04280	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8S71_04285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8S71_04290	COG3284	Transcriptional regulator
H8S71_04300	COG1742	UPF0060 membrane protein
H8S71_04325	COG4842	Belongs to the WXG100 family
H8S71_04340	COG5444	nuclease activity
H8S71_04355	COG1486	melibiose metabolic process
H8S71_04360	COG1737	Transcriptional regulator
H8S71_04365	COG1263	PTS System
H8S71_04365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_04370	COG1132	(ABC) transporter
H8S71_04375	COG1132	(ABC) transporter
H8S71_04380	COG2259	Doxx family
H8S71_04385	COG2514	catechol 2,3-dioxygenase activity
H8S71_04390	COG4585	Histidine kinase
H8S71_04395	COG2197	response regulator
H8S71_04400	COG1131	(ABC) transporter
H8S71_04405	COG0842	Transport permease protein
H8S71_04405	COG1511	domain protein
H8S71_04410	COG0842	Transport permease protein
H8S71_04415	COG1695	Transcriptional regulator
H8S71_04420	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H8S71_04425	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
H8S71_04430	COG1309	transcriptional regulator
H8S71_04435	COG2814	Major facilitator Superfamily
H8S71_04440	COG2318	DinB family
H8S71_04445	COG2814	Major facilitator Superfamily
H8S71_04450	COG1846	Transcriptional regulator
H8S71_04455	COG0392	lysyltransferase activity
H8S71_04455	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8S71_04460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_04465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_04470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_04475	COG0384	phenazine biosynthesis protein PhzF
H8S71_04480	COG0778	Nitroreductase
H8S71_04495	COG1090	epimerase
H8S71_04500	COG2137	regulation of response to DNA damage stimulus
H8S71_04510	COG2814	Major facilitator Superfamily
H8S71_04525	COG3103	Sh3 type 3 domain protein
H8S71_04530	COG5658	integral membrane protein
H8S71_04535	COG0596	Alpha beta hydrolase
H8S71_04540	COG0463	Glycosyl transferase, family 2
H8S71_04545	COG4485	Bacterial membrane protein, YfhO
H8S71_04550	COG1988	membrane-bound metal-dependent
H8S71_04555	COG1194	a g-specific adenine glycosylase
H8S71_04565	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_04580	COG3557	Belongs to the UPF0374 family
H8S71_04585	COG1132	(ABC) transporter
H8S71_04590	COG4129	membrane
H8S71_04595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8S71_04600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8S71_04605	COG0735	belongs to the Fur family
H8S71_04715	COG4326	sporulation control protein
H8S71_04725	COG5577	PFAM Coat F domain
H8S71_04730	COG3340	Belongs to the peptidase S51 family
H8S71_04735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8S71_04745	COG0753	catalase activity
H8S71_04750	COG1116	anion transmembrane transporter activity
H8S71_04755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8S71_04760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8S71_04765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_04775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H8S71_04785	COG1476	TRANSCRIPTIONal
H8S71_04795	COG3382	B3 4 domain protein
H8S71_04800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8S71_04810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8S71_04815	COG0789	Transcriptional regulator
H8S71_04820	COG1664	Polymer-forming cytoskeletal
H8S71_04825	COG1664	Polymer-forming cytoskeletal
H8S71_04830	COG2766	serine protein kinase
H8S71_04835	COG2718	Belongs to the UPF0229 family
H8S71_04840	COG1846	Transcriptional regulator
H8S71_04845	COG1566	PFAM secretion protein HlyD family protein
H8S71_04850	COG2814	Major facilitator Superfamily
H8S71_04855	COG0655	NAD(P)H dehydrogenase (quinone) activity
H8S71_04875	COG1725	Transcriptional regulator
H8S71_04880	COG1131	(ABC) transporter
H8S71_04885	COG1131	(ABC) transporter
H8S71_04890	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H8S71_04895	COG1278	Cold shock
H8S71_04900	COG1464	Belongs to the NlpA lipoprotein family
H8S71_04905	COG3706	GGDEF domain
H8S71_04910	COG1823	symporter activity
H8S71_04930	COG5577	PFAM Coat F domain
H8S71_04935	COG1525	nuclease
H8S71_04935	COG0737	Belongs to the 5'-nucleotidase family
H8S71_04935	COG4085	toxin activity
H8S71_04940	COG3764	Sortase (surface protein transpeptidase)
H8S71_04945	COG0564	pseudouridine synthase activity
H8S71_04955	COG0517	IMP dehydrogenase activity
H8S71_04960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8S71_04965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8S71_04965	COG3153	acetyltransferase
H8S71_04970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8S71_04975	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H8S71_04980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8S71_04985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8S71_04990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H8S71_04995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8S71_05000	COG4585	Histidine kinase
H8S71_05000	COG2203	Gaf domain
H8S71_05005	COG2197	response regulator
H8S71_05010	COG0431	NADPH-dependent FMN reductase
H8S71_05025	COG0791	NLP P60 protein
H8S71_05025	COG1388	LysM domain
H8S71_05030	COG1959	2 iron, 2 sulfur cluster binding
H8S71_05035	COG0668	transmembrane transport
H8S71_05040	COG2719	SpoVR family
H8S71_05045	COG1785	Belongs to the alkaline phosphatase family
H8S71_05050	COG0791	NLP P60 protein
H8S71_05050	COG1388	LysM domain
H8S71_05055	COG0583	DNA-binding transcription factor activity
H8S71_05060	COG0372	Belongs to the citrate synthase family
H8S71_05065	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_05070	COG0531	amino acid
H8S71_05075	COG0733	neurotransmitter:sodium symporter activity
H8S71_05080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_05085	COG0456	acetyltransferase
H8S71_05100	COG1595	DNA-templated transcription, initiation
H8S71_05105	COG0667	Aldo Keto reductase
H8S71_05110	COG0204	Acyl-transferase
H8S71_05115	COG1253	flavin adenine dinucleotide binding
H8S71_05120	COG0789	Transcriptional regulator
H8S71_05125	COG0436	Aminotransferase
H8S71_05130	COG1253	flavin adenine dinucleotide binding
H8S71_05135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8S71_05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8S71_05145	COG0584	glycerophosphoryl diester phosphodiesterase
H8S71_05155	COG0668	transmembrane transport
H8S71_05160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8S71_05165	COG0726	polysaccharide deacetylase
H8S71_05170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8S71_05175	COG1757	Na H antiporter
H8S71_05180	COG0589	response to stress
H8S71_05190	COG1132	(ABC) transporter
H8S71_05195	COG1132	(ABC) transporter
H8S71_05200	COG0702	epimerase
H8S71_05220	COG0189	ligase activity
H8S71_05225	COG0189	ligase activity
H8S71_05230	COG4399	Belongs to the UPF0754 family
H8S71_05235	COG3679	Belongs to the UPF0342 family
H8S71_05240	COG4335	DNA alkylation repair
H8S71_05245	COG0561	phosphatase activity
H8S71_05250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8S71_05255	COG0475	glutathione-regulated potassium exporter activity
H8S71_05260	COG0490	domain, Protein
H8S71_05270	COG1024	Enoyl-CoA hydratase
H8S71_05280	COG4152	abc transporter atp-binding protein
H8S71_05285	COG1668	transmembrane transport
H8S71_05290	COG0420	3'-5' exonuclease activity
H8S71_05295	COG4717	serine-type aminopeptidase activity
H8S71_05300	COG3481	metal-dependent phosphohydrolase, HD sub domain
H8S71_05310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8S71_05340	COG1846	Transcriptional regulator
H8S71_05345	COG4980	gas vesicle protein
H8S71_05360	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8S71_05365	COG0537	adenosine 5'-monophosphoramidase activity
H8S71_05370	COG1131	(ABC) transporter
H8S71_05375	COG4473	ABC transporter
H8S71_05385	COG1473	amidohydrolase
H8S71_05390	COG3069	C4-dicarboxylate transmembrane transporter activity
H8S71_05400	COG2329	Antibiotic biosynthesis monooxygenase
H8S71_05405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8S71_05410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8S71_05415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8S71_05420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H8S71_05425	COG1309	transcriptional regulator
H8S71_05430	COG1511	domain protein
H8S71_05435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8S71_05440	COG4377	Putative membrane peptidase family (DUF2324)
H8S71_05450	COG1363	Peptidase, m42
H8S71_05455	COG4405	Protein conserved in bacteria
H8S71_05460	COG1301	dicarboxylic acid transport
H8S71_05470	COG1234	tRNA 3'-trailer cleavage
H8S71_05475	COG0095	Lipoate-protein ligase
H8S71_05480	COG0702	epimerase
H8S71_05485	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_05495	COG0501	Belongs to the peptidase M48B family
H8S71_05505	COG0456	acetyltransferase
H8S71_05510	COG0604	alcohol dehydrogenase
H8S71_05515	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H8S71_05520	COG0406	alpha-ribazole phosphatase activity
H8S71_05525	COG0183	Belongs to the thiolase family
H8S71_05530	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_05535	COG1268	BioY protein
H8S71_05540	COG0840	transmembrane signaling receptor activity
H8S71_05545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8S71_05545	COG0723	plastoquinol--plastocyanin reductase activity
H8S71_05550	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_05560	COG4903	ComK protein
H8S71_05565	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_05575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_05590	COG0398	Pfam SNARE associated Golgi protein
H8S71_05595	COG0681	Belongs to the peptidase S26 family
H8S71_05600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8S71_05605	COG1846	Transcriptional regulator
H8S71_05615	COG0738	Major facilitator superfamily
H8S71_05620	COG0673	inositol 2-dehydrogenase activity
H8S71_05625	COG0561	phosphatase activity
H8S71_05630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8S71_05635	COG1609	Transcriptional regulator
H8S71_05640	COG3180	Ammonia monooxygenase
H8S71_05645	COG0477	Major facilitator Superfamily
H8S71_05645	COG2814	Major facilitator Superfamily
H8S71_05650	COG4533	DNA binding
H8S71_05660	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8S71_05665	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H8S71_05670	COG1074	ATP-dependent DNA helicase activity
H8S71_05675	COG0420	3'-5' exonuclease activity
H8S71_05680	COG0419	ATPase involved in DNA repair
H8S71_05685	COG1403	HNH endonuclease
H8S71_05725	COG5337	Spore coat protein CotH
H8S71_05730	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8S71_05740	COG1404	Belongs to the peptidase S8 family
H8S71_05750	COG0367	asparagine synthase
H8S71_05755	COG2318	DinB family
H8S71_05760	COG1562	ergosterol biosynthetic process
H8S71_05765	COG0534	Mate efflux family protein
H8S71_05770	COG2207	Transcriptional regulator
H8S71_05770	COG1917	Cupin 2, conserved barrel domain protein
H8S71_05775	COG1609	Transcriptional regulator
H8S71_05780	COG0673	inositol 2-dehydrogenase activity
H8S71_05785	COG2318	DinB family
H8S71_05790	COG1279	arginine transmembrane transporter activity
H8S71_05795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_05800	COG1357	PFAM Pentapeptide repeats (8 copies)
H8S71_05805	COG2267	carboxylic ester hydrolase activity
H8S71_05810	COG0529	Catalyzes the synthesis of activated sulfate
H8S71_05815	COG2046	Belongs to the sulfate adenylyltransferase family
H8S71_05820	COG0175	sulfate reduction
H8S71_05825	COG2045	Belongs to the ComB family
H8S71_05830	COG1809	phosphosulfolactate synthase activity
H8S71_05835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_05840	COG4948	Mandelate Racemase Muconate Lactonizing
H8S71_05845	COG2814	Major facilitator Superfamily
H8S71_05850	COG0454	-acetyltransferase
H8S71_05855	COG2153	protein acetylation
H8S71_05860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8S71_05860	COG0646	methionine synthase
H8S71_05865	COG1666	GTP binding
H8S71_05870	COG2996	Protein conserved in bacteria
H8S71_05890	COG1695	Transcriptional regulator
H8S71_05905	COG3227	Zinc metalloprotease (Elastase)
H8S71_05910	COG1307	EDD domain protein, DegV family
H8S71_05915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_05935	COG0561	phosphatase activity
H8S71_05940	COG1073	alpha beta
H8S71_05945	COG2151	metal-sulfur cluster biosynthetic enzyme
H8S71_05955	COG0277	FAD linked oxidase domain protein
H8S71_05960	COG2271	Major facilitator Superfamily
H8S71_05965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8S71_05970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H8S71_05980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8S71_05985	COG0505	Belongs to the CarA family
H8S71_05990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8S71_05995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8S71_06010	COG2267	carboxylic ester hydrolase activity
H8S71_06020	COG1744	ABC transporter substrate-binding protein PnrA-like
H8S71_06035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8S71_06040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8S71_06045	COG5504	Zn-dependent protease
H8S71_06050	COG0444	Belongs to the ABC transporter superfamily
H8S71_06055	COG4608	Belongs to the ABC transporter superfamily
H8S71_06065	COG0601	transmembrane transport
H8S71_06070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8S71_06080	COG0180	Tryptophanyl-tRNA synthetase
H8S71_06085	COG4166	transmembrane transport
H8S71_06090	COG0601	transmembrane transport
H8S71_06095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8S71_06100	COG0444	Belongs to the ABC transporter superfamily
H8S71_06105	COG4608	Belongs to the ABC transporter superfamily
H8S71_06110	COG2814	Major facilitator Superfamily
H8S71_06115	COG0456	acetyltransferase
H8S71_06120	COG1393	Belongs to the ArsC family
H8S71_06125	COG0861	Integral membrane protein TerC family
H8S71_06135	COG4862	establishment of competence for transformation
H8S71_06145	COG4469	Competence protein
H8S71_06150	COG1164	Oligoendopeptidase f
H8S71_06160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8S71_06165	COG2346	COG2346, Truncated hemoglobins
H8S71_06170	COG0741	lytic transglycosylase activity
H8S71_06175	COG4116	CYTH
H8S71_06185	COG2357	RelA SpoT domain protein
H8S71_06190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8S71_06195	COG0564	pseudouridine synthase activity
H8S71_06200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8S71_06205	COG0569	domain protein
H8S71_06205	COG0475	glutathione-regulated potassium exporter activity
H8S71_06210	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H8S71_06215	COG0352	thiamine-phosphate diphosphorylase activity
H8S71_06220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8S71_06225	COG2104	thiamine diphosphate biosynthetic process
H8S71_06230	COG2022	thiamine diphosphate biosynthetic process
H8S71_06235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8S71_06240	COG0351	phosphomethylpyrimidine kinase
H8S71_06245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8S71_06300	COG0210	DNA helicase
H8S71_06310	COG2153	protein acetylation
H8S71_06315	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H8S71_06320	COG2382	esterase
H8S71_06325	COG0626	cystathionine gamma-synthase activity
H8S71_06330	COG0626	cystathionine gamma-synthase activity
H8S71_06335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_06340	COG5505	Protein of unknown function (DUF819)
H8S71_06420	COG5444	nuclease activity
H8S71_06450	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H8S71_06455	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_06465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_06465	COG3711	transcriptional antiterminator
H8S71_06470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8S71_06470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8S71_06470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_06475	COG1482	cell wall glycoprotein biosynthetic process
H8S71_06485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_06495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8S71_06510	COG0109	protoheme IX farnesyltransferase activity
H8S71_06520	COG0726	polysaccharide deacetylase
H8S71_06535	COG5504	Zn-dependent protease
H8S71_06540	COG2205	protein histidine kinase activity
H8S71_06550	COG3383	formate dehydrogenase (NAD+) activity
H8S71_06555	COG2427	Protein of unknown function (DUF1641)
H8S71_06565	COG1051	belongs to the nudix hydrolase family
H8S71_06575	COG2124	cytochrome p450
H8S71_06580	COG1819	glycosyl
H8S71_06590	COG1587	Uroporphyrinogen-III synthase
H8S71_06595	COG0390	transport system, permease component
H8S71_06600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8S71_06605	COG0697	spore germination
H8S71_06610	COG4297	protein containing double-stranded beta helix domain
H8S71_06620	COG1252	NADH dehydrogenase
H8S71_06625	COG1904	glucuronate isomerase
H8S71_06630	COG2211	Major facilitator Superfamily
H8S71_06635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H8S71_06640	COG1063	alcohol dehydrogenase
H8S71_06645	COG1312	Catalyzes the dehydration of D-mannonate
H8S71_06650	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_06655	COG2271	Major facilitator Superfamily
H8S71_06660	COG1609	Transcriptional regulator
H8S71_06665	COG0246	Mannitol dehydrogenase
H8S71_06670	COG2721	sulfolactate sulfo-lyase activity
H8S71_06675	COG0730	response to heat
H8S71_06680	COG2318	DinB family
H8S71_06690	COG0457	Tetratricopeptide repeat
H8S71_06700	COG2350	Protein conserved in bacteria
H8S71_06705	COG5632	N-Acetylmuramoyl-L-alanine amidase
H8S71_06705	COG1388	LysM domain
H8S71_06705	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_06715	COG4195	phage-related replication protein
H8S71_06720	COG3546	catalase activity
H8S71_06725	COG2856	Zn peptidase
H8S71_06730	COG1396	sequence-specific DNA binding
H8S71_06740	COG1522	sequence-specific DNA binding
H8S71_06745	COG1484	DNA-dependent DNA replication
H8S71_06765	COG1595	DNA-templated transcription, initiation
H8S71_06770	COG3728	DNA packaging
H8S71_06770	COG5484	DNA packaging
H8S71_06775	COG1783	phage Terminase large subunit
H8S71_06780	COG5518	Phage portal protein
H8S71_06785	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H8S71_06790	COG4653	Phage capsid family
H8S71_06840	COG3953	SLT domain
H8S71_06840	COG5412	phage tail tape measure protein
H8S71_06845	COG1652	LysM domain
H8S71_06850	COG4193	domain, Protein
H8S71_06860	COG3628	GPW Gp25 family protein
H8S71_06865	COG3299	homolog of phage Mu protein gp47
H8S71_06870	COG3778	Protein conserved in bacteria
H8S71_06910	COG5632	N-Acetylmuramoyl-L-alanine amidase
H8S71_06910	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_06930	COG0306	phosphate transporter
H8S71_06935	COG1392	Phosphate transport regulator
H8S71_06940	COG0531	amino acid
H8S71_06945	COG0346	lactoylglutathione lyase activity
H8S71_06950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H8S71_06955	COG0463	Glycosyl transferase, family 2
H8S71_06965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8S71_06970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8S71_06975	COG2362	D-Aminopeptidase
H8S71_06980	COG0601	transmembrane transport
H8S71_06985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8S71_06990	COG0444	Belongs to the ABC transporter superfamily
H8S71_06995	COG4166	transmembrane transport
H8S71_07000	COG1619	proteins homologs of microcin C7 resistance protein MccF
H8S71_07005	COG4948	Mandelate Racemase Muconate Lactonizing
H8S71_07010	COG0791	NLP P60 protein
H8S71_07015	COG4608	Belongs to the ABC transporter superfamily
H8S71_07020	COG2706	6-phosphogluconolactonase activity
H8S71_07025	COG1834	amidinotransferase
H8S71_07030	COG1607	acyl-coa hydrolase
H8S71_07035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8S71_07035	COG1017	nitric oxide dioxygenase activity
H8S71_07045	COG2323	membrane
H8S71_07050	COG2318	DinB family
H8S71_07055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_07060	COG2076	Multidrug Resistance protein
H8S71_07065	COG2076	Multidrug Resistance protein
H8S71_07070	COG0788	formyltetrahydrofolate deformylase activity
H8S71_07075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8S71_07080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8S71_07085	COG1764	response to oxidative stress
H8S71_07090	COG1846	Transcriptional regulator
H8S71_07095	COG1764	response to oxidative stress
H8S71_07105	COG0590	tRNA wobble adenosine to inosine editing
H8S71_07110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H8S71_07115	COG1404	Belongs to the peptidase S8 family
H8S71_07120	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_07125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H8S71_07130	COG1122	ATPase activity
H8S71_07135	COG4721	ABC-type cobalt transport system, permease component
H8S71_07145	COG0745	RESPONSE REGULATOR receiver
H8S71_07150	COG3850	Histidine kinase
H8S71_07150	COG5002	protein histidine kinase activity
H8S71_07155	COG3212	peptidase
H8S71_07160	COG3212	peptidase
H8S71_07170	COG2239	Acts as a magnesium transporter
H8S71_07175	COG0789	Transcriptional regulator
H8S71_07190	COG1846	Transcriptional regulator
H8S71_07195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8S71_07200	COG0726	polysaccharide deacetylase
H8S71_07205	COG1408	metallophosphoesterase
H8S71_07215	COG0463	Glycosyl transferase, family 2
H8S71_07220	COG3285	dna ligase
H8S71_07220	COG1793	dna ligase
H8S71_07225	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H8S71_07235	COG0586	Pfam SNARE associated Golgi protein
H8S71_07240	COG0861	Integral membrane protein TerC family
H8S71_07245	COG1191	sigma factor activity
H8S71_07265	COG0501	Belongs to the peptidase M48B family
H8S71_07270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8S71_07285	COG3594	Acyltransferase
H8S71_07290	COG5002	protein histidine kinase activity
H8S71_07295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H8S71_07305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8S71_07310	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H8S71_07315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8S71_07320	COG0436	Aminotransferase
H8S71_07325	COG1850	ribulose-bisphosphate carboxylase activity
H8S71_07330	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
H8S71_07335	COG0235	Class ii aldolase
H8S71_07340	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8S71_07345	COG3339	Conserved Protein
H8S71_07360	COG3852	Histidine kinase
H8S71_07365	COG1846	Transcriptional regulator
H8S71_07370	COG1360	Flagellar Motor Protein
H8S71_07375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8S71_07380	COG0542	response to heat
H8S71_07385	COG3949	Membrane
H8S71_07390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8S71_07395	COG0720	synthase
H8S71_07400	COG0602	queuosine metabolic process
H8S71_07405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8S71_07410	COG1733	regulation of RNA biosynthetic process
H8S71_07415	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_07420	COG1388	LysM domain
H8S71_07420	COG4641	Protein conserved in bacteria
H8S71_07425	COG1388	LysM domain
H8S71_07430	COG3858	chitin binding
H8S71_07440	COG4873	Protein conserved in bacteria
H8S71_07450	COG3773	Cell wall hydrolase
H8S71_07455	COG2244	polysaccharide biosynthetic process
H8S71_07460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_07465	COG2217	Heavy metal translocating P-type atpase
H8S71_07475	COG0006	proline dipeptidase activity
H8S71_07480	COG1609	Transcriptional regulator
H8S71_07485	COG3711	transcriptional antiterminator
H8S71_07490	COG1263	PTS System
H8S71_07490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_07490	COG2190	(PTS) system
H8S71_07495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_07500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8S71_07510	COG1533	DNA photolyase activity
H8S71_07515	COG0456	acetyltransferase
H8S71_07520	COG0840	transmembrane signaling receptor activity
H8S71_07525	COG2084	Dehydrogenase
H8S71_07530	COG4257	antibiotic catabolic process
H8S71_07535	COG2340	Cysteine-rich secretory protein family
H8S71_07540	COG0768	penicillin binding
H8S71_07545	COG4191	Histidine kinase
H8S71_07550	COG0436	Aminotransferase
H8S71_07560	COG0784	Response regulator, receiver
H8S71_07560	COG0835	chemotaxis
H8S71_07570	COG2814	Major facilitator Superfamily
H8S71_07575	COG1376	ErfK ybiS ycfS ynhG family protein
H8S71_07580	COG1408	metallophosphoesterase
H8S71_07585	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_07590	COG2200	EAL domain
H8S71_07595	COG4703	Protein of unknown function (DUF1797)
H8S71_07600	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H8S71_07610	COG0517	IMP dehydrogenase activity
H8S71_07615	COG0583	DNA-binding transcription factor activity
H8S71_07620	COG0716	FMN binding
H8S71_07630	COG0716	FMN binding
H8S71_07635	COG2171	N-acyltransferase activity
H8S71_07640	COG1473	amidohydrolase
H8S71_07650	COG0668	transmembrane transport
H8S71_07655	COG0450	alkyl hydroperoxide reductase
H8S71_07660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_07675	COG0746	molybdenum cofactor guanylyltransferase activity
H8S71_07680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8S71_07685	COG0303	'Molybdopterin
H8S71_07690	COG1763	Mo-molybdopterin cofactor biosynthetic process
H8S71_07695	COG0314	molybdopterin synthase activity
H8S71_07700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8S71_07705	COG1132	(ABC) transporter
H8S71_07710	COG1132	(ABC) transporter
H8S71_07720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8S71_07725	COG1136	(ABC) transporter
H8S71_07730	COG0577	efflux transmembrane transporter activity
H8S71_07735	COG1349	DNA-binding transcription factor activity
H8S71_07740	COG1105	Belongs to the carbohydrate kinase PfkB family
H8S71_07745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8S71_07745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8S71_07745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_07750	COG0681	Belongs to the peptidase S26 family
H8S71_07760	COG0488	(ABC) transporter
H8S71_07765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8S71_07770	COG2309	aminopeptidase activity
H8S71_07780	COG1077	Cell shape determining protein MreB Mrl
H8S71_07785	COG2002	toxin-antitoxin pair type II binding
H8S71_07790	COG3852	Histidine kinase
H8S71_07795	COG2105	PFAM AIG2 family protein
H8S71_07795	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H8S71_07800	COG0569	domain protein
H8S71_07805	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H8S71_07810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8S71_07815	COG5503	Protein of unknown function (DUF1447)
H8S71_07820	COG0561	phosphatase activity
H8S71_07825	COG0242	peptide deformylase activity
H8S71_07835	COG0497	DNA recombination
H8S71_07840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8S71_07845	COG0022	dehydrogenase e1 component
H8S71_07850	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8S71_07855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8S71_07860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_07870	COG1982	Orn Lys Arg decarboxylase major
H8S71_07875	COG4476	Belongs to the UPF0223 family
H8S71_07880	COG4493	Belongs to the UPF0637 family
H8S71_07890	COG0483	inositol monophosphate 1-phosphatase activity
H8S71_07900	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H8S71_07920	COG1595	DNA-templated transcription, initiation
H8S71_07940	COG1217	gtp-binding protein TYPA
H8S71_07950	COG4896	Protein conserved in bacteria
H8S71_07960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8S71_07965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8S71_07970	COG2066	Belongs to the glutaminase family
H8S71_07975	COG4838	Belongs to the UPF0358 family
H8S71_07980	COG0772	Belongs to the SEDS family
H8S71_07985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H8S71_07990	COG1612	heme a metabolic process
H8S71_07995	COG0109	protoheme IX farnesyltransferase activity
H8S71_08000	COG2010	Cytochrome c
H8S71_08000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8S71_08005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8S71_08010	COG1845	cytochrome c oxidase, subunit III
H8S71_08015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8S71_08020	COG3336	cytochrome c oxidase
H8S71_08030	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H8S71_08035	COG2340	Cysteine-rich secretory protein family
H8S71_08050	COG3679	Belongs to the UPF0342 family
H8S71_08055	COG4471	UPF0298 protein
H8S71_08060	COG0742	ribosomal rna small subunit methyltransferase
H8S71_08065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8S71_08070	COG3314	Sporulation integral membrane protein YlbJ
H8S71_08075	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8S71_08080	COG3480	Lon protease (S16) C-terminal proteolytic domain
H8S71_08085	COG1323	Belongs to the UPF0348 family
H8S71_08095	COG1399	metal-binding, possibly nucleic acid-binding protein
H8S71_08110	COG0454	-acetyltransferase
H8S71_08115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8S71_08120	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H8S71_08125	COG2001	Belongs to the MraZ family
H8S71_08130	COG0275	rRNA processing
H8S71_08135	COG4839	cell division protein FtsL
H8S71_08140	COG0768	penicillin binding
H8S71_08145	COG0768	penicillin binding
H8S71_08150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8S71_08155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8S71_08160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8S71_08165	COG0772	Belongs to the SEDS family
H8S71_08170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8S71_08175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8S71_08180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8S71_08185	COG3879	Bacterial protein of unknown function (DUF881)
H8S71_08190	COG3879	Bacterial protein of unknown function (DUF881)
H8S71_08195	COG3856	small basic protein
H8S71_08200	COG0849	cell division
H8S71_08205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H8S71_08210	COG4412	M6 family metalloprotease domain protein
H8S71_08210	COG1404	Belongs to the peptidase S8 family
H8S71_08220	COG1191	sigma factor activity
H8S71_08225	COG1191	sigma factor activity
H8S71_08230	COG1119	ATPase activity
H8S71_08235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8S71_08240	COG1873	PFAM PRC-barrel domain
H8S71_08245	COG1496	oxidoreductase activity
H8S71_08250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8S71_08255	COG1799	cell septum assembly
H8S71_08260	COG0762	integral membrane protein
H8S71_08265	COG2302	S4 RNA-binding domain
H8S71_08270	COG3599	regulation of cell shape
H8S71_08275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8S71_08280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8S71_08285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8S71_08290	COG0564	pseudouridine synthase activity
H8S71_08295	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H8S71_08300	COG2233	PERMEase
H8S71_08305	COG0540	Belongs to the ATCase OTCase family
H8S71_08310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8S71_08315	COG0505	Belongs to the CarA family
H8S71_08320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8S71_08325	COG0543	2 iron, 2 sulfur cluster binding
H8S71_08330	COG0167	dihydroorotate dehydrogenase activity
H8S71_08335	COG0284	orotidine-5'-phosphate decarboxylase activity
H8S71_08340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8S71_08345	COG0175	sulfate reduction
H8S71_08350	COG0306	phosphate transporter
H8S71_08355	COG2046	Belongs to the sulfate adenylyltransferase family
H8S71_08360	COG0529	Catalyzes the synthesis of activated sulfate
H8S71_08365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8S71_08370	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H8S71_08375	COG1648	precorrin-2 dehydrogenase activity
H8S71_08380	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H8S71_08385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8S71_08390	COG1561	YicC-like family, N-terminal region
H8S71_08400	COG0194	GDP metabolic process
H8S71_08405	COG1758	RNA polymerase activity
H8S71_08410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8S71_08415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8S71_08420	COG0242	peptide deformylase activity
H8S71_08425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8S71_08430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8S71_08430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8S71_08435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8S71_08440	COG0631	protein serine/threonine phosphatase activity
H8S71_08445	COG2815	serine threonine protein kinase
H8S71_08445	COG0515	serine threonine protein kinase
H8S71_08450	COG1162	GTPase activity
H8S71_08455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8S71_08460	COG1564	THIamine pyrophosphokinase
H8S71_08470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H8S71_08475	COG1302	Protein conserved in bacteria
H8S71_08480	COG1461	Dihydroxyacetone kinase
H8S71_08485	COG1760	l-serine dehydratase
H8S71_08490	COG1760	l-serine dehydratase
H8S71_08495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8S71_08500	COG1349	DNA-binding transcription factor activity
H8S71_08500	COG2050	protein possibly involved in aromatic compounds catabolism
H8S71_08505	COG0416	fatty acid biosynthetic process
H8S71_08510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8S71_08515	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_08525	COG0571	ribonuclease III activity
H8S71_08530	COG1196	nuclear chromosome segregation
H8S71_08535	COG0552	protein localization to endoplasmic reticulum
H8S71_08545	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H8S71_08550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8S71_08555	COG0228	four-way junction DNA binding
H8S71_08560	COG1837	Belongs to the UPF0109 family
H8S71_08570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8S71_08575	COG0336	Belongs to the RNA methyltransferase TrmD family
H8S71_08580	COG0335	large ribosomal subunit rRNA binding
H8S71_08585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H8S71_08590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8S71_08600	COG2257	FlhB HrpN YscU SpaS Family
H8S71_08605	COG0045	succinate-CoA ligase (ADP-forming) activity
H8S71_08610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8S71_08615	COG0758	DNA mediated transformation
H8S71_08620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8S71_08625	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H8S71_08630	COG4974	Belongs to the 'phage' integrase family
H8S71_08635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8S71_08640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8S71_08645	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H8S71_08650	COG1815	bacterial-type flagellum-dependent cell motility
H8S71_08655	COG1558	bacterial-type flagellum-dependent cell motility
H8S71_08660	COG1677	Flagellar hook-basal body complex protein FliE
H8S71_08665	COG1766	The M ring may be actively involved in energy transduction
H8S71_08670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H8S71_08675	COG1317	bacterial-type flagellum organization
H8S71_08680	COG1157	protein secretion by the type III secretion system
H8S71_08685	COG2882	bacterial-type flagellum organization
H8S71_08690	COG3334	PFAM MgtE intracellular
H8S71_08695	COG3144	bacterial-type flagellum assembly
H8S71_08700	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8S71_08705	COG4786	Flagellar basal body rod
H8S71_08710	COG1582	Flagellar protein (FlbD)
H8S71_08715	COG1580	Controls the rotational direction of flagella during chemotaxis
H8S71_08720	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H8S71_08725	COG1776	CheC inhibitor of MCP methylation
H8S71_08725	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H8S71_08730	COG2201	protein-glutamate methylesterase activity
H8S71_08735	COG3190	flagellar
H8S71_08740	COG1338	Plays a role in the flagellum-specific transport system
H8S71_08745	COG1987	bacterial-type flagellum assembly
H8S71_08750	COG1684	flagellar biosynthetic protein fliR
H8S71_08755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8S71_08760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8S71_08765	COG1419	protein localization to endoplasmic reticulum
H8S71_08770	COG0455	bacterial-type flagellum organization
H8S71_08775	COG2201	protein-glutamate methylesterase activity
H8S71_08780	COG0643	Histidine kinase
H8S71_08780	COG2198	Histidine kinase
H8S71_08785	COG0835	chemotaxis
H8S71_08790	COG1776	CheC inhibitor of MCP methylation
H8S71_08795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8S71_08800	COG1191	sigma factor activity
H8S71_08810	COG0052	Belongs to the universal ribosomal protein uS2 family
H8S71_08815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8S71_08820	COG0528	UMP kinase activity
H8S71_08825	COG0233	cytoplasmic translational termination
H8S71_08830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8S71_08835	COG4589	Belongs to the CDS family
H8S71_08840	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8S71_08845	COG0750	zinc metalloprotease
H8S71_08850	COG0442	prolyl-tRNA aminoacylation
H8S71_08855	COG2176	DNA-directed DNA polymerase activity
H8S71_08860	COG0779	Required for maturation of 30S ribosomal subunits
H8S71_08865	COG0195	Participates in both transcription termination and antitermination
H8S71_08870	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H8S71_08875	COG1358	cellular component organization or biogenesis
H8S71_08880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8S71_08885	COG1550	Protein conserved in bacteria
H8S71_08890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8S71_08895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8S71_08900	COG0196	riboflavin kinase activity
H8S71_08905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8S71_08910	COG1185	polyribonucleotide nucleotidyltransferase activity
H8S71_08915	COG0726	polysaccharide deacetylase
H8S71_08920	COG0612	Peptidase, M16
H8S71_08925	COG1873	PFAM PRC-barrel domain
H8S71_08930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8S71_08935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8S71_08940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8S71_08945	COG0527	aspartate kinase activity
H8S71_08950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8S71_08955	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8S71_08960	COG0740	serine-type endopeptidase activity
H8S71_08970	COG1674	ftsk spoiiie
H8S71_08970	COG4980	gas vesicle protein
H8S71_08975	COG2188	Transcriptional regulator
H8S71_08980	COG2814	Major facilitator Superfamily
H8S71_08985	COG0612	Peptidase, M16
H8S71_08990	COG0612	Peptidase, M16
H8S71_08995	COG0300	oxidoreductase activity
H8S71_09010	COG1426	Protein conserved in bacteria
H8S71_09015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8S71_09020	COG1546	Belongs to the CinA family
H8S71_09020	COG1058	Belongs to the CinA family
H8S71_09025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8S71_09030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8S71_09035	COG1418	mRNA catabolic process
H8S71_09040	COG1692	metallophosphoesterase
H8S71_09045	COG2359	stage V sporulation protein S
H8S71_09050	COG1063	alcohol dehydrogenase
H8S71_09055	COG0156	8-amino-7-oxononanoate synthase activity
H8S71_09060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8S71_09065	COG4550	Control of competence regulator ComK, YlbF/YmcA
H8S71_09075	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8S71_09080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8S71_09095	COG3226	Transcriptional regulator
H8S71_09100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_09110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8S71_09115	COG3321	synthase
H8S71_09120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8S71_09120	COG2070	2-Nitropropane dioxygenase
H8S71_09125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_09130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8S71_09135	COG3425	synthase
H8S71_09140	COG1024	Enoyl-CoA hydratase
H8S71_09145	COG1024	Enoyl-CoA hydratase
H8S71_09150	COG0300	oxidoreductase activity
H8S71_09150	COG3321	synthase
H8S71_09150	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_09150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_09150	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_09155	COG4221	oxidoreductase activity
H8S71_09155	COG3321	synthase
H8S71_09155	COG0300	oxidoreductase activity
H8S71_09155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_09160	COG3321	synthase
H8S71_09160	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_09160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_09160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8S71_09160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_09165	COG3321	synthase
H8S71_09165	COG4221	oxidoreductase activity
H8S71_09165	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_09165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_09170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8S71_09170	COG3321	synthase
H8S71_09170	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H8S71_09170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_09175	COG2124	cytochrome p450
H8S71_09185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_09190	COG1404	Belongs to the peptidase S8 family
H8S71_09200	COG4195	phage-related replication protein
H8S71_09205	COG1764	response to oxidative stress
H8S71_09210	COG2076	Multidrug Resistance protein
H8S71_09215	COG2076	Multidrug Resistance protein
H8S71_09230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8S71_09235	COG1923	regulation of RNA biosynthetic process
H8S71_09250	COG1780	Probably involved in ribonucleotide reductase function
H8S71_09255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8S71_09260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8S71_09265	COG4112	unkown
H8S71_09270	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_09275	COG0464	growth
H8S71_09280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8S71_09285	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H8S71_09290	COG0789	Transcriptional regulator
H8S71_09295	COG0174	glutamine synthetase
H8S71_09320	COG4282	regulation of fungal-type cell wall biogenesis
H8S71_09330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_09340	COG0135	phosphoribosylanthranilate isomerase activity
H8S71_09345	COG2211	Major facilitator Superfamily
H8S71_09350	COG3507	Belongs to the glycosyl hydrolase 43 family
H8S71_09355	COG1940	carbohydrate kinase activity
H8S71_09360	COG2115	Belongs to the xylose isomerase family
H8S71_09365	COG1070	Carbohydrate kinase
H8S71_09375	COG1525	nuclease
H8S71_09380	COG2814	Major facilitator Superfamily
H8S71_09385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8S71_09395	COG0756	dUTP diphosphatase activity
H8S71_09435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8S71_09450	COG3832	glyoxalase III activity
H8S71_09460	COG0697	spore germination
H8S71_09465	COG0531	amino acid
H8S71_09495	COG4195	phage-related replication protein
H8S71_09505	COG0346	lactoylglutathione lyase activity
H8S71_09510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8S71_09515	COG1388	LysM domain
H8S71_09520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8S71_09525	COG4224	UPF0291 protein
H8S71_09530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8S71_09540	COG3763	UPF0154 protein
H8S71_09550	COG0785	Cytochrome C biogenesis protein
H8S71_09555	COG2201	protein-glutamate methylesterase activity
H8S71_09560	COG4846	Membrane protein involved in cytochrome C biogenesis
H8S71_09570	COG0071	Belongs to the small heat shock protein (HSP20) family
H8S71_09585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H8S71_09590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_09610	COG0824	Thioesterase
H8S71_09620	COG4841	protein insertion into membrane
H8S71_09625	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H8S71_09630	COG1832	CoA-binding protein
H8S71_09635	COG0187	DNA topoisomerase II activity
H8S71_09640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8S71_09650	COG1115	amino acid carrier protein
H8S71_09655	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8S71_09665	COG5520	Belongs to the glycosyl hydrolase 30 family
H8S71_09670	COG3507	Belongs to the glycosyl hydrolase 43 family
H8S71_09675	COG2246	polysaccharide biosynthetic process
H8S71_09680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8S71_09685	COG0586	Pfam SNARE associated Golgi protein
H8S71_09690	COG2404	hydrolase activity, acting on ester bonds
H8S71_09695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8S71_09700	COG1024	Enoyl-CoA hydratase
H8S71_09705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8S71_09710	COG0511	ligase activity, forming carbon-carbon bonds
H8S71_09715	COG0439	Biotin carboxylase
H8S71_09720	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_09725	COG1960	acyl-CoA dehydrogenase activity
H8S71_09735	COG1649	PFAM Uncharacterised BCR, COG1649
H8S71_09745	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H8S71_09745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_09750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_09755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_09760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_09765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_09770	COG2027	D-alanyl-D-alanine carboxypeptidase
H8S71_09775	COG2017	converts alpha-aldose to the beta-anomer
H8S71_09780	COG0534	Mate efflux family protein
H8S71_09795	COG0582	viral genome integration into host DNA
H8S71_09800	COG0166	Belongs to the GPI family
H8S71_09805	COG0405	Gamma-glutamyltransferase
H8S71_09810	COG0583	DNA-binding transcription factor activity
H8S71_09815	COG0604	alcohol dehydrogenase
H8S71_09820	COG0493	'glutamate synthase
H8S71_09825	COG0070	glutamate synthase
H8S71_09825	COG0069	glutamate synthase activity
H8S71_09825	COG0067	glutamate synthase
H8S71_09830	COG0583	DNA-binding transcription factor activity
H8S71_09835	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8S71_09840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8S71_09850	COG0300	oxidoreductase activity
H8S71_09855	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H8S71_09865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_09870	COG2814	Major facilitator Superfamily
H8S71_09875	COG1070	Carbohydrate kinase
H8S71_09880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8S71_09885	COG0243	molybdopterin cofactor binding
H8S71_09915	COG0840	transmembrane signaling receptor activity
H8S71_09915	COG5278	phosphoserine phosphatase activity
H8S71_09920	COG2368	4-hydroxyphenylacetate
H8S71_09925	COG4305	rare lipoprotein A
H8S71_09930	COG3619	membrane
H8S71_09935	COG3866	Pectate lyase
H8S71_09940	COG2135	peptidase activity
H8S71_09950	COG2140	Oxalate decarboxylase
H8S71_09980	COG2720	vancomycin resistance protein
H8S71_09995	COG3739	integral membrane protein
H8S71_10000	COG0583	DNA-binding transcription factor activity
H8S71_10005	COG0697	spore germination
H8S71_10015	COG0693	protein deglycase activity
H8S71_10020	COG2367	Beta-lactamase
H8S71_10035	COG3848	Pyruvate phosphate dikinase
H8S71_10035	COG0574	Belongs to the PEP-utilizing enzyme family
H8S71_10040	COG0726	polysaccharide deacetylase
H8S71_10045	COG1793	dna ligase
H8S71_10080	COG5444	nuclease activity
H8S71_10085	COG4282	regulation of fungal-type cell wall biogenesis
H8S71_10090	COG1231	oxidoreductase activity
H8S71_10100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_10105	COG0662	Cupin 2, conserved barrel domain protein
H8S71_10105	COG2207	Transcriptional regulator
H8S71_10110	COG0456	acetyltransferase
H8S71_10115	COG1309	transcriptional regulator
H8S71_10120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_10125	COG3708	Transcriptional regulator
H8S71_10130	COG2378	regulation of single-species biofilm formation
H8S71_10140	COG0640	Transcriptional regulator
H8S71_10145	COG0741	lytic transglycosylase activity
H8S71_10150	COG2322	membrane
H8S71_10165	COG1619	proteins homologs of microcin C7 resistance protein MccF
H8S71_10170	COG3239	Fatty acid desaturase
H8S71_10175	COG4585	Histidine kinase
H8S71_10180	COG2197	response regulator
H8S71_10185	COG1388	LysM domain
H8S71_10185	COG3584	3D domain protein
H8S71_10190	COG0514	ATP-dependent DNA helicase (RecQ)
H8S71_10200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8S71_10205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8S71_10220	COG0071	Belongs to the small heat shock protein (HSP20) family
H8S71_10245	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_10250	COG1657	PFAM Prenyltransferase squalene oxidase
H8S71_10255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8S71_10260	COG0733	neurotransmitter:sodium symporter activity
H8S71_10265	COG0385	Bile acid
H8S71_10270	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8S71_10275	COG0567	Dehydrogenase, E1 component
H8S71_10280	COG4548	von Willebrand factor, type A
H8S71_10285	COG0714	Associated with various cellular activities
H8S71_10290	COG2032	superoxide dismutase activity
H8S71_10295	COG1388	LysM domain
H8S71_10295	COG0791	NLP P60 protein
H8S71_10300	COG1819	glycosyl
H8S71_10305	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H8S71_10310	COG0534	Mate efflux family protein
H8S71_10315	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_10320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H8S71_10325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H8S71_10335	COG2962	Rard protein
H8S71_10350	COG2610	gluconate transmembrane transporter activity
H8S71_10355	COG1942	4-Oxalocrotonate Tautomerase
H8S71_10360	COG1733	regulation of RNA biosynthetic process
H8S71_10365	COG0778	Nitroreductase
H8S71_10370	COG0400	carboxylic ester hydrolase activity
H8S71_10375	COG0346	lactoylglutathione lyase activity
H8S71_10385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_10390	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_10390	COG0793	Belongs to the peptidase S41A family
H8S71_10395	COG2226	methyltransferase
H8S71_10405	COG1876	peptidase activity
H8S71_10410	COG0813	purine-nucleoside phosphorylase activity
H8S71_10425	COG0671	phosphoesterase, PA-phosphatase related
H8S71_10445	COG4479	Belongs to the UPF0346 family
H8S71_10455	COG1509	lysine 2,3-aminomutase activity
H8S71_10460	COG0456	acetyltransferase
H8S71_10465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8S71_10470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8S71_10475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8S71_10480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8S71_10495	COG0456	acetyltransferase
H8S71_10500	COG0463	Glycosyl transferase, family 2
H8S71_10515	COG4641	Protein conserved in bacteria
H8S71_10520	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
H8S71_10525	COG1086	Polysaccharide biosynthesis protein
H8S71_10530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8S71_10535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8S71_10540	COG1846	Transcriptional regulator
H8S71_10545	COG0534	Mate efflux family protein
H8S71_10555	COG4698	Protein conserved in bacteria
H8S71_10560	COG2755	lipolytic protein G-D-S-L family
H8S71_10565	COG1999	signal sequence binding
H8S71_10575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8S71_10580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H8S71_10585	COG1272	protein, Hemolysin III
H8S71_10590	COG0204	Acyl-transferase
H8S71_10595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H8S71_10600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H8S71_10610	COG2521	methyltransferase
H8S71_10610	COG2136	Putative SAM-dependent methyltransferase
H8S71_10620	COG0129	dihydroxy-acid dehydratase activity
H8S71_10625	COG1413	lyase activity
H8S71_10630	COG1418	mRNA catabolic process
H8S71_10635	COG0386	Belongs to the glutathione peroxidase family
H8S71_10640	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H8S71_10645	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8S71_10655	COG1278	Cold shock
H8S71_10675	COG0328	RNA-DNA hybrid ribonuclease activity
H8S71_10680	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8S71_10685	COG0328	RNA-DNA hybrid ribonuclease activity
H8S71_10695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8S71_10710	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H8S71_10725	COG3424	synthase
H8S71_10730	COG2233	PERMEase
H8S71_10735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8S71_10740	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H8S71_10750	COG0800	Aldolase
H8S71_10755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_10760	COG1609	Transcriptional regulator
H8S71_10765	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8S71_10770	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_10775	COG1199	ATP-dependent helicase activity
H8S71_10790	COG0116	Belongs to the methyltransferase superfamily
H8S71_10805	COG4474	Belongs to the UPF0398 family
H8S71_10820	COG3359	exonuclease
H8S71_10825	COG1205	dead DEAH box helicase
H8S71_10825	COG1111	helicase
H8S71_10830	COG2190	(PTS) system
H8S71_10835	COG0071	Belongs to the small heat shock protein (HSP20) family
H8S71_10870	COG3331	DNA recombination
H8S71_10875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8S71_10875	COG4499	WXG100 protein secretion system (Wss), protein YukC
H8S71_10885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8S71_10890	COG3935	DnaD domain protein
H8S71_10895	COG0017	Asparaginyl-tRNA synthetase
H8S71_10900	COG0436	Aminotransferase
H8S71_10905	COG5353	protein conserved in bacteria
H8S71_10915	COG1199	ATP-dependent helicase activity
H8S71_10915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8S71_10920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8S71_10925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8S71_10930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8S71_10935	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H8S71_10935	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H8S71_10940	COG0617	tRNA 3'-terminal CCA addition
H8S71_10945	COG0438	transferase activity, transferring glycosyl groups
H8S71_10950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H8S71_10955	COG1803	Methylglyoxal synthase
H8S71_10960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8S71_10965	COG1694	Mazg nucleotide pyrophosphohydrolase
H8S71_10970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_10980	COG4347	Protein of unknown function (DUF1405)
H8S71_10985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8S71_10985	COG2010	Cytochrome c
H8S71_10990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8S71_10995	COG0723	plastoquinol--plastocyanin reductase activity
H8S71_11005	COG5582	Belongs to the UPF0302 family
H8S71_11010	COG0457	Tetratricopeptide repeat
H8S71_11015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8S71_11020	COG0287	Prephenate dehydrogenase
H8S71_11030	COG0159	tryptophan synthase activity
H8S71_11035	COG0133	tryptophan synthase activity
H8S71_11040	COG0135	phosphoribosylanthranilate isomerase activity
H8S71_11050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8S71_11055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8S71_11060	COG4401	Chorismate mutase type I
H8S71_11065	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8S71_11070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8S71_11075	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8S71_11080	COG0105	UTP biosynthetic process
H8S71_11085	COG0142	geranyltranstransferase activity
H8S71_11090	COG2226	methyltransferase
H8S71_11095	COG0142	geranyltranstransferase activity
H8S71_11105	COG0302	gtp cyclohydrolase
H8S71_11110	COG0776	regulation of translation
H8S71_11115	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H8S71_11130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8S71_11135	COG1160	GTP binding
H8S71_11160	COG1304	FMN binding
H8S71_11165	COG0539	negative regulation of cytoplasmic translation
H8S71_11170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8S71_11180	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H8S71_11185	COG2959	enzyme of heme biosynthesis
H8S71_11190	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_11190	COG3773	Cell wall hydrolase
H8S71_11195	COG2339	peptidase activity
H8S71_11200	COG0492	ferredoxin-NADP+ reductase activity
H8S71_11205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H8S71_11210	COG4862	establishment of competence for transformation
H8S71_11215	COG1408	metallophosphoesterase
H8S71_11225	COG1388	LysM domain
H8S71_11230	COG1266	CAAX protease self-immunity
H8S71_11235	COG0514	ATP-dependent DNA helicase (RecQ)
H8S71_11240	COG4955	Helix-turn-helix domain
H8S71_11245	COG1141	Ferredoxin
H8S71_11250	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H8S71_11255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8S71_11260	COG0710	3-dehydroquinate dehydratase activity
H8S71_11270	COG1595	DNA-templated transcription, initiation
H8S71_11275	COG5002	protein histidine kinase activity
H8S71_11280	COG0745	RESPONSE REGULATOR receiver
H8S71_11285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8S71_11290	COG1333	cytochrome c biogenesis protein
H8S71_11295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_11300	COG1187	pseudouridine synthase activity
H8S71_11305	COG0700	Nucleoside recognition
H8S71_11310	COG2715	membrane protein required for spore maturation
H8S71_11315	COG1686	Belongs to the peptidase S11 family
H8S71_11325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8S71_11330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8S71_11335	COG1547	Domain of unknown function (DUF309)
H8S71_11340	COG0456	acetyltransferase
H8S71_11345	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8S71_11350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8S71_11350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8S71_11355	COG0307	riboflavin synthase, alpha
H8S71_11360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8S71_11360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8S71_11370	COG0681	Belongs to the peptidase S26 family
H8S71_11380	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
H8S71_11410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8S71_11415	COG4086	secreted protein
H8S71_11420	COG0019	diaminopimelate decarboxylase activity
H8S71_11425	COG0697	spore germination
H8S71_11440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8S71_11460	COG1191	sigma factor activity
H8S71_11465	COG2172	sigma factor antagonist activity
H8S71_11470	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_11475	COG1686	Belongs to the peptidase S11 family
H8S71_11480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8S71_11485	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H8S71_11490	COG4974	Belongs to the 'phage' integrase family
H8S71_11500	COG0735	belongs to the Fur family
H8S71_11505	COG1300	Membrane
H8S71_11515	COG0281	malic enzyme
H8S71_11520	COG1757	Na H antiporter
H8S71_11525	COG1027	Aspartate ammonia-lyase
H8S71_11530	COG0252	asparaginase activity
H8S71_11535	COG1396	sequence-specific DNA binding
H8S71_11540	COG1379	DNA repair
H8S71_11545	COG0494	nUDIX hydrolase
H8S71_11555	COG0667	Aldo Keto reductase
H8S71_11565	COG1073	alpha beta
H8S71_11575	COG4918	Iron-sulphur cluster biosynthesis
H8S71_11580	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H8S71_11580	COG0456	acetyltransferase
H8S71_11585	COG2329	Antibiotic biosynthesis monooxygenase
H8S71_11590	COG0456	acetyltransferase
H8S71_11600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8S71_11610	COG2211	Major facilitator Superfamily
H8S71_11620	COG0346	lactoylglutathione lyase activity
H8S71_11625	COG1072	(Pantothenic acid kinase))
H8S71_11630	COG3048	D-serine ammonia-lyase activity
H8S71_11635	COG0300	oxidoreductase activity
H8S71_11640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_11645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8S71_11650	COG4187	Peptidase family M20/M25/M40
H8S71_11655	COG1902	pentaerythritol trinitrate reductase activity
H8S71_11660	COG0596	Alpha beta hydrolase
H8S71_11670	COG1234	tRNA 3'-trailer cleavage
H8S71_11675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8S71_11680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8S71_11685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8S71_11695	COG0706	membrane insertase activity
H8S71_11700	COG3361	conserved protein (COG2071)
H8S71_11705	COG2195	Cleaves the N-terminal amino acid of tripeptides
H8S71_11710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8S71_11715	COG0346	lactoylglutathione lyase activity
H8S71_11725	COG1376	ErfK ybiS ycfS ynhG family protein
H8S71_11730	COG4129	membrane
H8S71_11735	COG1126	abc transporter atp-binding protein
H8S71_11740	COG0765	amino acid transport
H8S71_11745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_11755	COG1597	lipid kinase activity
H8S71_11760	COG2814	Major facilitator Superfamily
H8S71_11765	COG0789	Transcriptional regulator
H8S71_11765	COG4978	Transcriptional regulator
H8S71_11770	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8S71_11775	COG0022	dehydrogenase e1 component
H8S71_11780	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8S71_11785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8S71_11790	COG3426	butyrate kinase activity
H8S71_11795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H8S71_11800	COG0280	phosphate acetyltransferase
H8S71_11805	COG3290	protein histidine kinase activity
H8S71_11805	COG3829	transcription factor binding
H8S71_11815	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H8S71_11820	COG2079	MmgE PrpD family protein
H8S71_11825	COG0372	Belongs to the citrate synthase family
H8S71_11830	COG1960	acyl-CoA dehydrogenase activity
H8S71_11835	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8S71_11840	COG0183	Belongs to the thiolase family
H8S71_11845	COG0584	glycerophosphoryl diester phosphodiesterase
H8S71_11850	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_11865	COG1902	pentaerythritol trinitrate reductase activity
H8S71_11870	COG0745	RESPONSE REGULATOR receiver
H8S71_11875	COG0750	zinc metalloprotease
H8S71_11880	COG0497	DNA recombination
H8S71_11885	COG1438	arginine binding
H8S71_11890	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H8S71_11895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8S71_11900	COG0142	geranyltranstransferase activity
H8S71_11905	COG1722	exodeoxyribonuclease VII activity
H8S71_11910	COG1570	exodeoxyribonuclease VII activity
H8S71_11915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8S71_11920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8S71_11925	COG1302	Protein conserved in bacteria
H8S71_11930	COG0439	Biotin carboxylase
H8S71_11935	COG0511	ligase activity, forming carbon-carbon bonds
H8S71_11975	COG3854	ATPases associated with a variety of cellular activities
H8S71_11985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8S71_11990	COG0006	proline dipeptidase activity
H8S71_11995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8S71_12005	COG3872	metal-dependent enzyme
H8S71_12015	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8S71_12020	COG1321	iron dependent repressor
H8S71_12025	COG0095	Lipoate-protein ligase
H8S71_12030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8S71_12035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8S71_12040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8S71_12045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8S71_12050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8S71_12065	COG1396	sequence-specific DNA binding
H8S71_12075	COG0681	Belongs to the peptidase S26 family
H8S71_12100	COG4940	Competence protein ComGF
H8S71_12110	COG4970	Tfp pilus assembly protein FimT
H8S71_12115	COG4537	Required for transformation and DNA binding
H8S71_12120	COG1459	type II secretion system
H8S71_12125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8S71_12130	COG0598	Magnesium transport protein CorA
H8S71_12135	COG1253	flavin adenine dinucleotide binding
H8S71_12140	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_12150	COG1393	Belongs to the ArsC family
H8S71_12160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_12170	COG0011	TIGRFAM Protein of
H8S71_12180	COG2866	Carboxypeptidase
H8S71_12185	COG1368	sulfuric ester hydrolase activity
H8S71_12190	COG1940	carbohydrate kinase activity
H8S71_12195	COG4483	Protein conserved in bacteria
H8S71_12200	COG0457	Tetratricopeptide repeat
H8S71_12200	COG0705	Rhomboid family
H8S71_12210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8S71_12220	COG0438	transferase activity, transferring glycosyl groups
H8S71_12235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8S71_12240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8S71_12245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8S71_12250	COG0581	inorganic phosphate transmembrane transporter activity
H8S71_12255	COG0573	inorganic phosphate transmembrane transporter activity
H8S71_12260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8S71_12265	COG0768	penicillin binding
H8S71_12270	COG0477	Major facilitator Superfamily
H8S71_12275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8S71_12280	COG2839	Protein conserved in bacteria
H8S71_12285	COG5521	maltodextrose utilization protein MalA
H8S71_12290	COG1388	LysM domain
H8S71_12295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8S71_12300	COG4709	membrane
H8S71_12305	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H8S71_12310	COG0735	belongs to the Fur family
H8S71_12315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_12325	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H8S71_12330	COG0513	Belongs to the DEAD box helicase family
H8S71_12340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8S71_12345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H8S71_12350	COG2384	SAM-dependent methyltransferase
H8S71_12355	COG2010	Cytochrome c
H8S71_12360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8S71_12365	COG0358	DNA primase activity
H8S71_12370	COG1671	Belongs to the UPF0178 family
H8S71_12375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8S71_12380	COG0517	IMP dehydrogenase activity
H8S71_12385	COG0751	glycine-tRNA ligase activity
H8S71_12390	COG0752	glycyl-tRNA synthetase alpha subunit
H8S71_12395	COG1381	Involved in DNA repair and RecF pathway recombination
H8S71_12405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8S71_12410	COG0295	cytidine deaminase activity
H8S71_12415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8S71_12420	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8S71_12425	COG1480	7TM receptor with intracellular HD hydrolase
H8S71_12430	COG1702	phosphate starvation-inducible protein PhoH
H8S71_12435	COG0561	phosphatase activity
H8S71_12450	COG4864	UPF0365 protein
H8S71_12455	COG1030	water channel activity
H8S71_12460	COG1610	YqeY-like protein
H8S71_12470	COG1283	sodium-dependent phosphate transmembrane transporter activity
H8S71_12475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8S71_12480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8S71_12485	COG2264	protein methyltransferase activity
H8S71_12490	COG0484	heat shock protein binding
H8S71_12495	COG0443	Heat shock 70 kDa protein
H8S71_12500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8S71_12505	COG1420	regulation of RNA biosynthetic process
H8S71_12510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8S71_12515	COG0481	GTPase activity
H8S71_12525	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_12530	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H8S71_12535	COG0268	Binds directly to 16S ribosomal RNA
H8S71_12540	COG1466	dna polymerase III delta subunit
H8S71_12555	COG0658	competence protein
H8S71_12555	COG2333	competence protein COMEC
H8S71_12560	COG2131	deaminase
H8S71_12565	COG1596	polysaccharide export
H8S71_12565	COG1555	photosystem II stabilization
H8S71_12570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8S71_12575	COG2226	methyltransferase
H8S71_12580	COG0799	negative regulation of ribosome biogenesis
H8S71_12585	COG1713	HD superfamily hydrolase involved in NAD metabolism
H8S71_12590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8S71_12595	COG1534	Rna-binding protein
H8S71_12600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8S71_12605	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H8S71_12610	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H8S71_12620	COG2755	lipolytic protein G-D-S-L family
H8S71_12625	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_12625	COG5632	N-Acetylmuramoyl-L-alanine amidase
H8S71_12630	COG0398	Pfam SNARE associated Golgi protein
H8S71_12635	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8S71_12645	COG3209	COG3209 Rhs family protein
H8S71_12660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8S71_12665	COG3223	Belongs to the PsiE family
H8S71_12670	COG0642	Histidine kinase
H8S71_12670	COG5002	protein histidine kinase activity
H8S71_12675	COG0745	RESPONSE REGULATOR receiver
H8S71_12680	COG2311	Membrane
H8S71_12690	COG0454	-acetyltransferase
H8S71_12695	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8S71_12705	COG0730	response to heat
H8S71_12710	COG0425	Belongs to the sulfur carrier protein TusA family
H8S71_12715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8S71_12715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_12725	COG0425	Belongs to the sulfur carrier protein TusA family
H8S71_12725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8S71_12730	COG2210	Belongs to the sulfur carrier protein TusA family
H8S71_12735	COG1937	Protein conserved in bacteria
H8S71_12740	COG0662	Cupin 2, conserved barrel domain protein
H8S71_12750	COG0789	Transcriptional regulator
H8S71_12750	COG4978	Transcriptional regulator
H8S71_12755	COG2814	Major facilitator Superfamily
H8S71_12760	COG0456	acetyltransferase
H8S71_12765	COG1253	flavin adenine dinucleotide binding
H8S71_12775	COG0697	spore germination
H8S71_12780	COG0583	DNA-binding transcription factor activity
H8S71_12785	COG2072	flavoprotein involved in K transport
H8S71_12790	COG1230	cation diffusion facilitator family transporter
H8S71_12795	COG1942	4-Oxalocrotonate Tautomerase
H8S71_12800	COG0583	DNA-binding transcription factor activity
H8S71_12810	COG1114	Component of the transport system for branched-chain amino acids
H8S71_12815	COG1687	branched-chain amino acid
H8S71_12820	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H8S71_12825	COG1522	sequence-specific DNA binding
H8S71_12835	COG2124	cytochrome p450
H8S71_12850	COG1335	isochorismatase
H8S71_12865	COG2318	DinB family
H8S71_12875	COG2070	2-Nitropropane dioxygenase
H8S71_12880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8S71_12890	COG2186	Transcriptional regulator
H8S71_12905	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_12910	COG3958	Transketolase
H8S71_12915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8S71_12920	COG0477	Major facilitator Superfamily
H8S71_12925	COG1846	Transcriptional regulator
H8S71_12930	COG3443	Belongs to the bacterial solute-binding protein 9 family
H8S71_12935	COG1595	DNA-templated transcription, initiation
H8S71_12940	COG0667	Aldo Keto reductase
H8S71_12945	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_12950	COG5566	PFAM Mor transcription activator
H8S71_12955	COG0596	Alpha beta hydrolase
H8S71_12960	COG4991	sh3 domain protein
H8S71_12965	COG4991	sh3 domain protein
H8S71_12975	COG0346	lactoylglutathione lyase activity
H8S71_12985	COG5577	PFAM Coat F domain
H8S71_12990	COG1063	alcohol dehydrogenase
H8S71_13000	COG5577	PFAM Coat F domain
H8S71_13005	COG0789	Transcriptional regulator
H8S71_13015	COG1064	alcohol dehydrogenase
H8S71_13020	COG0693	protein deglycase activity
H8S71_13025	COG1621	beta-fructofuranosidase activity
H8S71_13030	COG3716	PTS system mannose fructose sorbose family IID component
H8S71_13035	COG3715	PTS system
H8S71_13040	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_13045	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_13050	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H8S71_13050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H8S71_13060	COG1113	amino acid transport
H8S71_13065	COG1280	lysine exporter protein (LysE YggA)
H8S71_13070	COG1378	Sugar-specific transcriptional regulator TrmB
H8S71_13075	COG1595	DNA-templated transcription, initiation
H8S71_13085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8S71_13085	COG2755	lipolytic protein G-D-S-L family
H8S71_13095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8S71_13095	COG2124	cytochrome p450
H8S71_13100	COG1309	transcriptional regulator
H8S71_13105	COG2226	methyltransferase
H8S71_13120	COG2116	formate transmembrane transporter activity
H8S71_13125	COG5609	conserved protein (DUF2294)
H8S71_13130	COG3383	formate dehydrogenase (NAD+) activity
H8S71_13135	COG2427	Protein of unknown function (DUF1641)
H8S71_13145	COG0626	cystathionine gamma-synthase activity
H8S71_13150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8S71_13155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H8S71_13160	COG2226	methyltransferase
H8S71_13175	COG0768	penicillin binding
H8S71_13180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8S71_13185	COG0572	uridine kinase
H8S71_13190	COG0826	peptidase U32
H8S71_13195	COG0826	peptidase U32
H8S71_13200	COG4122	O-methyltransferase activity
H8S71_13205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8S71_13210	COG3906	Belongs to the UPF0473 family
H8S71_13215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8S71_13220	COG4472	Bacterial protein of unknown function (DUF965)
H8S71_13225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8S71_13230	COG0628	permease
H8S71_13235	COG1126	abc transporter atp-binding protein
H8S71_13240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_13245	COG0765	amino acid transport
H8S71_13250	COG0765	amino acid transport
H8S71_13265	COG3881	PFAM PRC-barrel domain
H8S71_13270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8S71_13275	COG0457	Tetratricopeptide repeat
H8S71_13280	COG0482	sulfurtransferase activity
H8S71_13285	COG1104	cysteine desulfurase activity
H8S71_13290	COG1959	2 iron, 2 sulfur cluster binding
H8S71_13295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8S71_13300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8S71_13310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8S71_13315	COG0124	histidyl-tRNA synthetase
H8S71_13325	COG3103	Sh3 type 3 domain protein
H8S71_13325	COG4991	sh3 domain protein
H8S71_13325	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_13330	COG1490	D-aminoacyl-tRNA deacylase activity
H8S71_13335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8S71_13340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8S71_13345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8S71_13345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H8S71_13350	COG5416	Lipopolysaccharide assembly protein A domain
H8S71_13355	COG0490	domain, Protein
H8S71_13360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8S71_13360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8S71_13370	COG2244	polysaccharide biosynthetic process
H8S71_13375	COG2323	membrane
H8S71_13385	COG1862	Preprotein translocase
H8S71_13390	COG0343	queuine tRNA-ribosyltransferase activity
H8S71_13395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8S71_13405	COG2255	four-way junction helicase activity
H8S71_13410	COG0632	four-way junction helicase activity
H8S71_13420	COG2814	Major facilitator Superfamily
H8S71_13425	COG0673	inositol 2-dehydrogenase activity
H8S71_13430	COG2112	serine threonine protein kinase
H8S71_13450	COG1115	amino acid carrier protein
H8S71_13455	COG0217	transcriptional regulatory protein
H8S71_13465	COG1388	LysM domain
H8S71_13470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H8S71_13475	COG0157	Belongs to the NadC ModD family
H8S71_13480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8S71_13485	COG1104	cysteine desulfurase activity
H8S71_13490	COG1827	regulation of RNA biosynthetic process
H8S71_13495	COG0077	Prephenate dehydratase
H8S71_13500	COG4492	Belongs to the UPF0735 family
H8S71_13505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8S71_13510	COG3290	protein histidine kinase activity
H8S71_13520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8S71_13525	COG2868	ribosomal protein
H8S71_13530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8S71_13535	COG1994	Peptidase M50
H8S71_13540	COG0739	heme binding
H8S71_13545	COG2894	cell division
H8S71_13550	COG0850	regulation of cytokinetic process
H8S71_13555	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H8S71_13565	COG1077	Cell shape determining protein MreB Mrl
H8S71_13570	COG2003	Belongs to the UPF0758 family
H8S71_13575	COG0424	maF-like protein
H8S71_13585	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8S71_13590	COG0285	dihydrofolate synthase activity
H8S71_13595	COG0525	valine-tRNA ligase activity
H8S71_13605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_13610	COG1388	LysM domain
H8S71_13615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8S71_13620	COG0113	porphobilinogen synthase activity
H8S71_13625	COG1587	Uroporphyrinogen-III synthase
H8S71_13630	COG0181	hydroxymethylbilane synthase activity
H8S71_13635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8S71_13640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8S71_13650	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8S71_13655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H8S71_13660	COG0470	DNA polymerase III
H8S71_13660	COG1067	ATP-dependent peptidase activity
H8S71_13665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8S71_13670	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8S71_13675	COG0457	Tetratricopeptide repeat
H8S71_13675	COG1477	protein flavinylation
H8S71_13680	COG0066	3-isopropylmalate dehydratase activity
H8S71_13685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8S71_13690	COG0473	3-isopropylmalate dehydrogenase activity
H8S71_13695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8S71_13700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8S71_13705	COG0440	acetolactate synthase activity
H8S71_13710	COG0028	Belongs to the TPP enzyme family
H8S71_13720	COG0454	-acetyltransferase
H8S71_13730	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
H8S71_13760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8S71_13780	COG0622	Phosphoesterase
H8S71_13785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8S71_13790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8S71_13795	COG5401	PFAM Sporulation and spore germination
H8S71_13800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8S71_13805	COG1846	Transcriptional regulator
H8S71_13810	COG2197	response regulator
H8S71_13815	COG0824	Thioesterase
H8S71_13820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8S71_13825	COG1053	succinate dehydrogenase
H8S71_13830	COG2009	succinate dehydrogenase
H8S71_13835	COG1719	4-vinyl reductase, 4VR
H8S71_13840	COG0527	aspartate kinase activity
H8S71_13845	COG0322	excinuclease ABC activity
H8S71_13850	COG3118	belongs to the thioredoxin family
H8S71_13860	COG3534	alpha-L-arabinofuranosidase
H8S71_13865	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H8S71_13870	COG2086	electron transfer activity
H8S71_13875	COG1024	Enoyl-CoA hydratase
H8S71_13880	COG1309	transcriptional regulator
H8S71_13885	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_13890	COG3766	membrane
H8S71_13895	COG1193	negative regulation of DNA recombination
H8S71_13900	COG1796	DNA polymerase
H8S71_13900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H8S71_13905	COG1286	toxin biosynthetic process
H8S71_13910	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H8S71_13915	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8S71_13920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_13920	COG0072	phenylalanine-tRNA ligase activity
H8S71_13925	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8S71_13935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8S71_13945	COG3835	regulator
H8S71_13950	COG0277	FAD linked oxidase domain protein
H8S71_13955	COG0247	lactate metabolic process
H8S71_13960	COG0346	lactoylglutathione lyase activity
H8S71_13965	COG1966	Carbon starvation protein
H8S71_13970	COG3534	alpha-L-arabinofuranosidase
H8S71_13975	COG0395	ABC-type sugar transport system, permease component
H8S71_13980	COG1175	transmembrane transport
H8S71_13985	COG1653	transport
H8S71_13990	COG0371	Dehydrogenase
H8S71_13995	COG0647	UMP catabolic process
H8S71_14000	COG0235	Class ii aldolase
H8S71_14005	COG1069	ribulokinase activity
H8S71_14010	COG2160	L-arabinose isomerase activity
H8S71_14015	COG3507	Belongs to the glycosyl hydrolase 43 family
H8S71_14020	COG1363	Peptidase, m42
H8S71_14030	COG3326	Membrane
H8S71_14035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H8S71_14040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H8S71_14045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8S71_14055	COG1346	cytolysis
H8S71_14060	COG1380	Effector of murein hydrolase LrgA
H8S71_14065	COG3279	Response regulator of the LytR AlgR family
H8S71_14070	COG3275	phosphorelay sensor kinase activity
H8S71_14075	COG1011	Hydrolase
H8S71_14080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8S71_14090	COG0398	Pfam SNARE associated Golgi protein
H8S71_14095	COG1484	DNA-dependent DNA replication
H8S71_14100	COG3611	Membrane attachment protein
H8S71_14105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8S71_14110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8S71_14115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8S71_14120	COG1733	regulation of RNA biosynthetic process
H8S71_14125	COG2814	Major facilitator Superfamily
H8S71_14130	COG0656	L-ascorbic acid biosynthetic process
H8S71_14135	COG0237	dephospho-CoA kinase activity
H8S71_14140	COG1971	Probably functions as a manganese efflux pump
H8S71_14145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8S71_14150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8S71_14150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8S71_14155	COG5002	protein histidine kinase activity
H8S71_14160	COG0745	RESPONSE REGULATOR receiver
H8S71_14165	COG0039	L-malate dehydrogenase activity
H8S71_14170	COG0538	isocitrate dehydrogenase activity
H8S71_14175	COG0372	Belongs to the citrate synthase family
H8S71_14180	COG2707	UPF0756 membrane protein
H8S71_14185	COG0628	permease
H8S71_14190	COG3030	protein affecting phage T7 exclusion by the F plasmid
H8S71_14195	COG0469	pyruvate kinase activity
H8S71_14200	COG0205	6-phosphofructokinase activity
H8S71_14205	COG0825	malonyl-CoA metabolic process
H8S71_14210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8S71_14215	COG0281	malic enzyme
H8S71_14220	COG0587	DNA-directed DNA polymerase activity
H8S71_14240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H8S71_14250	COG4109	DRTGG domain
H8S71_14255	COG0730	response to heat
H8S71_14260	COG1473	amidohydrolase
H8S71_14265	COG0196	riboflavin kinase activity
H8S71_14270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_14275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8S71_14280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_14285	COG1126	abc transporter atp-binding protein
H8S71_14290	COG0765	amino acid transport
H8S71_14295	COG0765	amino acid transport
H8S71_14300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_14305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_14310	COG0454	-acetyltransferase
H8S71_14315	COG0583	DNA-binding transcription factor activity
H8S71_14320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H8S71_14325	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_14330	COG0165	Argininosuccinate lyase
H8S71_14335	COG0137	argininosuccinate synthase activity
H8S71_14340	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8S71_14345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8S71_14355	COG0827	DNA restriction-modification system
H8S71_14360	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H8S71_14365	COG3874	Sporulation protein YtfJ
H8S71_14375	COG1714	RDD family
H8S71_14380	COG0616	signal peptide processing
H8S71_14385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8S71_14390	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H8S71_14395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8S71_14405	COG0301	tRNA thio-modification
H8S71_14410	COG1104	cysteine desulfurase activity
H8S71_14415	COG1114	Component of the transport system for branched-chain amino acids
H8S71_14420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H8S71_14425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H8S71_14430	COG1309	transcriptional regulator
H8S71_14435	COG1956	GAF domain-containing protein
H8S71_14440	COG2203	Gaf domain
H8S71_14440	COG2199	diguanylate cyclase activity
H8S71_14445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H8S71_14450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8S71_14455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8S71_14460	COG0454	-acetyltransferase
H8S71_14465	COG0517	IMP dehydrogenase activity
H8S71_14470	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8S71_14475	COG1360	Flagellar Motor Protein
H8S71_14480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8S71_14485	COG1609	Transcriptional regulator
H8S71_14490	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H8S71_14490	COG1605	Chorismate mutase
H8S71_14495	COG3118	belongs to the thioredoxin family
H8S71_14500	COG4980	gas vesicle protein
H8S71_14505	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H8S71_14510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8S71_14515	COG1674	ftsk spoiiie
H8S71_14520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_14525	COG4848	Belongs to the UPF0354 family
H8S71_14530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_14545	COG1363	Peptidase, m42
H8S71_14550	COG5584	Small secreted protein
H8S71_14555	COG0281	malic enzyme
H8S71_14560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_14565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8S71_14575	COG0510	thiamine kinase activity
H8S71_14580	COG1523	belongs to the glycosyl hydrolase 13 family
H8S71_14585	COG1597	lipid kinase activity
H8S71_14595	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H8S71_14600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8S71_14605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8S71_14610	COG2252	PERMEase
H8S71_14615	COG4473	ABC transporter
H8S71_14620	COG1131	(ABC) transporter
H8S71_14625	COG1349	DNA-binding transcription factor activity
H8S71_14630	COG1187	pseudouridine synthase activity
H8S71_14635	COG2244	polysaccharide biosynthetic process
H8S71_14640	COG2081	HI0933 family
H8S71_14645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8S71_14655	COG5578	integral membrane protein
H8S71_14660	COG0673	inositol 2-dehydrogenase activity
H8S71_14665	COG1653	transport
H8S71_14670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H8S71_14675	COG4209	transmembrane transport
H8S71_14680	COG2207	Transcriptional regulator
H8S71_14685	COG1653	transport
H8S71_14690	COG0395	ABC-type sugar transport system, permease component
H8S71_14695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8S71_14700	COG2124	cytochrome p450
H8S71_14705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8S71_14715	COG0156	8-amino-7-oxononanoate synthase activity
H8S71_14720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8S71_14730	COG1073	alpha beta
H8S71_14735	COG1609	Transcriptional regulator
H8S71_14740	COG1653	transport
H8S71_14745	COG1175	transmembrane transport
H8S71_14750	COG0395	ABC-type sugar transport system, permease component
H8S71_14755	COG1486	melibiose metabolic process
H8S71_14760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8S71_14765	COG0495	leucyl-tRNA aminoacylation
H8S71_14775	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_14775	COG2202	Pas domain
H8S71_14780	COG2814	Major facilitator Superfamily
H8S71_14785	COG2433	Pfam Transposase IS66
H8S71_14790	COG0577	efflux transmembrane transporter activity
H8S71_14795	COG1136	(ABC) transporter
H8S71_14800	COG2205	protein histidine kinase activity
H8S71_14805	COG0745	RESPONSE REGULATOR receiver
H8S71_14810	COG0577	efflux transmembrane transporter activity
H8S71_14815	COG1136	(ABC) transporter
H8S71_14830	COG1131	(ABC) transporter
H8S71_14835	COG1725	Transcriptional regulator
H8S71_14850	COG1242	4 iron, 4 sulfur cluster binding
H8S71_14855	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H8S71_14865	COG2267	carboxylic ester hydrolase activity
H8S71_14870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8S71_14875	COG1113	amino acid transport
H8S71_14880	COG0367	asparagine synthase
H8S71_14885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8S71_14890	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H8S71_14900	COG1506	peptidase
H8S71_14905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8S71_14910	COG1116	anion transmembrane transporter activity
H8S71_14915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8S71_14920	COG0494	nUDIX hydrolase
H8S71_14925	COG4824	toxin secretion phage lysis holin
H8S71_14930	COG0783	Belongs to the Dps family
H8S71_14945	COG1854	S-ribosylhomocysteine lyase activity
H8S71_14950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8S71_14955	COG0288	reversible hydration of carbon dioxide
H8S71_14960	COG0254	rRNA binding
H8S71_14965	COG1271	oxidase subunit
H8S71_14970	COG1294	oxidase, subunit
H8S71_14980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8S71_14985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8S71_14985	COG1321	iron dependent repressor
H8S71_14990	COG1121	(ABC) transporter
H8S71_14995	COG0803	Belongs to the bacterial solute-binding protein 9 family
H8S71_15000	COG4948	Mandelate Racemase Muconate Lactonizing
H8S71_15005	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_15010	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H8S71_15015	COG0596	Alpha beta hydrolase
H8S71_15020	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H8S71_15025	COG1169	isochorismate synthase
H8S71_15030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8S71_15035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8S71_15040	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8S71_15045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8S71_15050	COG0438	transferase activity, transferring glycosyl groups
H8S71_15060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_15065	COG0438	transferase activity, transferring glycosyl groups
H8S71_15070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_15075	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H8S71_15080	COG0058	SHG alpha-glucan phosphorylase activity
H8S71_15085	COG0297	glycogen (starch) synthase activity
H8S71_15090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8S71_15095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8S71_15100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8S71_15225	COG3859	Proton-coupled thiamine transporter YuaJ
H8S71_15230	COG1247	-acetyltransferase
H8S71_15235	COG2268	Band 7 protein
H8S71_15240	COG1585	Membrane protein implicated in regulation of membrane protease activity
H8S71_15245	COG2318	DinB family
H8S71_15255	COG1454	alcohol dehydrogenase
H8S71_15260	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_15265	COG1510	regulation of RNA biosynthetic process
H8S71_15275	COG0569	domain protein
H8S71_15280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8S71_15285	COG4682	membrane
H8S71_15290	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8S71_15295	COG0477	Major facilitator Superfamily
H8S71_15300	COG5553	Cysteine dioxygenase type I
H8S71_15310	COG1968	undecaprenyl-diphosphatase activity
H8S71_15315	COG0628	permease
H8S71_15320	COG0673	inositol 2-dehydrogenase activity
H8S71_15325	COG4806	L-rhamnose isomerase
H8S71_15330	COG3254	rhamnose metabolic process
H8S71_15335	COG1070	Carbohydrate kinase
H8S71_15340	COG1349	DNA-binding transcription factor activity
H8S71_15345	COG3347	Dehydrogenase
H8S71_15345	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_15350	COG0840	transmembrane signaling receptor activity
H8S71_15355	COG0840	transmembrane signaling receptor activity
H8S71_15360	COG0840	transmembrane signaling receptor activity
H8S71_15365	COG0840	transmembrane signaling receptor activity
H8S71_15380	COG0432	Pfam Uncharacterised protein family UPF0047
H8S71_15390	COG0366	Alpha amylase catalytic
H8S71_15395	COG1253	flavin adenine dinucleotide binding
H8S71_15400	COG2738	Putative neutral zinc metallopeptidase
H8S71_15415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8S71_15430	COG0166	Belongs to the GPI family
H8S71_15435	COG1979	alcohol dehydrogenase
H8S71_15440	COG1979	alcohol dehydrogenase
H8S71_15445	COG2155	Conserved Protein
H8S71_15450	COG1098	S1 RNA binding domain
H8S71_15455	COG0436	Aminotransferase
H8S71_15460	COG1522	sequence-specific DNA binding
H8S71_15465	COG2267	carboxylic ester hydrolase activity
H8S71_15475	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H8S71_15480	COG2205	protein histidine kinase activity
H8S71_15490	COG5018	Exonuclease
H8S71_15495	COG2814	Major facilitator Superfamily
H8S71_15500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8S71_15505	COG3011	Protein conserved in bacteria
H8S71_15515	COG3290	protein histidine kinase activity
H8S71_15520	COG4565	transcriptional regulatory protein
H8S71_15525	COG1744	ABC transporter substrate-binding protein PnrA-like
H8S71_15530	COG3845	ABC transporter
H8S71_15535	COG4603	Belongs to the binding-protein-dependent transport system permease family
H8S71_15540	COG1079	Belongs to the binding-protein-dependent transport system permease family
H8S71_15545	COG3493	citrate carrier protein
H8S71_15555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8S71_15555	COG2111	Na H antiporter
H8S71_15560	COG2111	Na H antiporter
H8S71_15565	COG1006	Multisubunit Na H antiporter MnhC subunit
H8S71_15570	COG0651	ATP synthesis coupled electron transport
H8S71_15575	COG1863	multisubunit Na H antiporter MnhE subunit
H8S71_15580	COG2212	antiporter activity
H8S71_15585	COG1320	monovalent cation:proton antiporter activity
H8S71_15590	COG2050	protein possibly involved in aromatic compounds catabolism
H8S71_15595	COG2197	response regulator
H8S71_15600	COG4585	Histidine kinase
H8S71_15610	COG0142	geranyltranstransferase activity
H8S71_15625	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H8S71_15630	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8S71_15635	COG1335	isochorismatase
H8S71_15640	COG5506	Protein of unknown function (DUF1694)
H8S71_15655	COG0628	permease
H8S71_15670	COG1418	mRNA catabolic process
H8S71_15675	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_15685	COG1511	domain protein
H8S71_15690	COG0433	COG0433 Predicted ATPase
H8S71_15690	COG1674	ftsk spoiiie
H8S71_15695	COG4499	WXG100 protein secretion system (Wss), protein YukC
H8S71_15700	COG5417	Belongs to the EsaB family
H8S71_15705	COG4842	Belongs to the WXG100 family
H8S71_15710	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H8S71_15710	COG2508	Transcriptional regulator
H8S71_15715	COG0686	Belongs to the AlaDH PNT family
H8S71_15720	COG5634	Uncharacterized conserved protein (DUF2278)
H8S71_15725	COG3251	PFAM MbtH domain protein
H8S71_15730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_15735	COG3433	isochorismatase activity
H8S71_15735	COG1535	isochorismatase
H8S71_15740	COG1021	2,3-dihydroxybenzoate-AMP ligase
H8S71_15745	COG1169	isochorismate synthase
H8S71_15750	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_15755	COG2819	hydrolase of the alpha beta superfamily
H8S71_15760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8S71_15765	COG1268	BioY protein
H8S71_15770	COG2056	Na+-H+ antiporter family
H8S71_15775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8S71_15780	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H8S71_15785	COG3584	3D domain protein
H8S71_15800	COG1252	NADH dehydrogenase
H8S71_15805	COG0492	ferredoxin-NADP+ reductase activity
H8S71_15815	COG0516	GMP reductase activity
H8S71_15820	COG2808	Putative FMN-binding domain
H8S71_15825	COG0456	acetyltransferase
H8S71_15830	COG0316	Belongs to the HesB IscA family
H8S71_15835	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8S71_15840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8S71_15845	COG4844	belongs to the
H8S71_15850	COG1252	NADH dehydrogenase
H8S71_15855	COG4837	Protein of unknown function (DUF1462)
H8S71_15860	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8S71_15865	COG0823	Involved in the tonB-independent uptake of proteins
H8S71_15865	COG1506	peptidase
H8S71_15865	COG4946	Tricorn protease homolog
H8S71_15870	COG0083	homoserine kinase activity
H8S71_15875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8S71_15880	COG0460	homoserine dehydrogenase
H8S71_15885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_15890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H8S71_15895	COG0647	UMP catabolic process
H8S71_15900	COG2445	Protein of unknown function DUF86
H8S71_15905	COG4470	Protein conserved in bacteria
H8S71_15915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8S71_15920	COG0739	heme binding
H8S71_15930	COG3377	Domain of unknown function (DUF1805)
H8S71_15935	COG0737	Belongs to the 5'-nucleotidase family
H8S71_15940	COG0730	response to heat
H8S71_15945	COG1801	Protein of unknown function DUF72
H8S71_15955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8S71_15960	COG2508	Transcriptional regulator
H8S71_15965	COG2233	PERMEase
H8S71_15970	COG2233	PERMEase
H8S71_15975	COG3648	Uricase
H8S71_15975	COG3195	allantoin biosynthetic process
H8S71_15980	COG2351	hydroxyisourate hydrolase activity
H8S71_15990	COG2080	2 iron, 2 sulfur cluster binding
H8S71_15995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8S71_16000	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8S71_16005	COG2068	MobA-Related Protein
H8S71_16010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8S71_16015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8S71_16020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8S71_16030	COG2356	endonuclease I
H8S71_16035	COG3842	ATPase activity
H8S71_16040	COG2188	Transcriptional regulator
H8S71_16045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_16050	COG0395	ABC-type sugar transport system, permease component
H8S71_16055	COG1175	transmembrane transport
H8S71_16060	COG1653	transport
H8S71_16065	COG2222	sugar isomerase
H8S71_16070	COG0322	excinuclease ABC activity
H8S71_16075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8S71_16090	COG0346	lactoylglutathione lyase activity
H8S71_16095	COG0640	Transcriptional regulator
H8S71_16100	COG0719	Fe-S assembly protein
H8S71_16105	COG0822	iron-sulfur transferase activity
H8S71_16110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8S71_16115	COG0719	Fe-S assembly protein
H8S71_16120	COG0396	ATPase activity
H8S71_16130	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8S71_16135	COG1464	Belongs to the NlpA lipoprotein family
H8S71_16140	COG2011	ABC-type metal ion transport system permease component
H8S71_16145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8S71_16155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_16160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H8S71_16170	COG0509	glycine decarboxylation via glycine cleavage system
H8S71_16175	COG1393	Belongs to the ArsC family
H8S71_16180	COG1960	acyl-CoA dehydrogenase activity
H8S71_16185	COG0183	Belongs to the thiolase family
H8S71_16190	COG1024	Enoyl-CoA hydratase
H8S71_16190	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8S71_16200	COG0506	proline dehydrogenase activity
H8S71_16210	COG5577	PFAM Coat F domain
H8S71_16215	COG1846	Transcriptional regulator
H8S71_16220	COG0477	Major facilitator Superfamily
H8S71_16225	COG1942	4-Oxalocrotonate Tautomerase
H8S71_16230	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_16235	COG0583	DNA-binding transcription factor activity
H8S71_16245	COG1120	ATPase activity
H8S71_16260	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_16265	COG0783	Belongs to the Dps family
H8S71_16270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8S71_16275	COG0745	RESPONSE REGULATOR receiver
H8S71_16280	COG2205	protein histidine kinase activity
H8S71_16280	COG2770	Histidine kinase
H8S71_16290	COG1309	transcriptional regulator
H8S71_16295	COG0114	fumarate hydratase activity
H8S71_16305	COG0697	spore germination
H8S71_16310	COG0814	amino acid
H8S71_16320	COG2197	response regulator
H8S71_16325	COG4585	Histidine kinase
H8S71_16330	COG4758	membrane
H8S71_16335	COG3595	metallopeptidase activity
H8S71_16340	COG1842	Phage shock protein A
H8S71_16345	COG4758	membrane
H8S71_16350	COG2814	Major facilitator Superfamily
H8S71_16355	COG2096	Adenosyltransferase
H8S71_16360	COG1120	ATPase activity
H8S71_16365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_16370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_16375	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_16380	COG3386	PFAM SMP-30 Gluconolaconase
H8S71_16385	COG2205	protein histidine kinase activity
H8S71_16390	COG0745	RESPONSE REGULATOR receiver
H8S71_16400	COG1191	sigma factor activity
H8S71_16410	COG2140	Oxalate decarboxylase
H8S71_16420	COG0577	efflux transmembrane transporter activity
H8S71_16425	COG1136	(ABC) transporter
H8S71_16430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8S71_16435	COG1120	ATPase activity
H8S71_16440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_16445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_16450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_16455	COG0531	amino acid
H8S71_16465	COG1988	membrane-bound metal-dependent
H8S71_16470	COG1368	sulfuric ester hydrolase activity
H8S71_16475	COG1910	domain protein
H8S71_16480	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8S71_16485	COG4149	molybdate abc transporter
H8S71_16490	COG0656	L-ascorbic acid biosynthetic process
H8S71_16500	COG0025	NhaP-type Na H and K H
H8S71_16505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8S71_16510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8S71_16515	COG3973	AAA domain
H8S71_16525	COG2860	membrane
H8S71_16530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8S71_16535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8S71_16540	COG2217	Heavy metal translocating P-type atpase
H8S71_16545	COG2217	Heavy metal translocating P-type atpase
H8S71_16550	COG2608	mercury ion transmembrane transporter activity
H8S71_16555	COG1937	Protein conserved in bacteria
H8S71_16560	COG0673	inositol 2-dehydrogenase activity
H8S71_16565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8S71_16570	COG1289	transmembrane transporter activity
H8S71_16580	COG2076	Multidrug Resistance protein
H8S71_16585	COG1309	transcriptional regulator
H8S71_16590	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_16600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8S71_16605	COG0557	exoribonuclease II activity
H8S71_16610	COG1647	Serine aminopeptidase, S33
H8S71_16615	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8S71_16620	COG0596	Alpha beta hydrolase
H8S71_16625	COG1476	TRANSCRIPTIONal
H8S71_16630	COG1396	sequence-specific DNA binding
H8S71_16635	COG1396	sequence-specific DNA binding
H8S71_16640	COG1733	regulation of RNA biosynthetic process
H8S71_16645	COG0840	transmembrane signaling receptor activity
H8S71_16650	COG1174	glycine betaine transport
H8S71_16655	COG1732	Glycine betaine
H8S71_16660	COG1174	glycine betaine transport
H8S71_16665	COG0517	IMP dehydrogenase activity
H8S71_16665	COG1125	glycine betaine transport
H8S71_16670	COG1510	regulation of RNA biosynthetic process
H8S71_16675	COG1174	glycine betaine transport
H8S71_16680	COG1732	Glycine betaine
H8S71_16685	COG1174	glycine betaine transport
H8S71_16690	COG0517	IMP dehydrogenase activity
H8S71_16690	COG1125	glycine betaine transport
H8S71_16695	COG1510	regulation of RNA biosynthetic process
H8S71_16700	COG2095	MarC family integral membrane protein
H8S71_16710	COG3064	Membrane
H8S71_16715	COG4640	response to antibiotic
H8S71_16720	COG0456	acetyltransferase
H8S71_16725	COG0148	phosphopyruvate hydratase activity
H8S71_16730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H8S71_16735	COG0149	triose-phosphate isomerase activity
H8S71_16740	COG0126	phosphoglycerate kinase activity
H8S71_16745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8S71_16750	COG2390	Transcriptional regulator
H8S71_16755	COG2814	Major facilitator Superfamily
H8S71_16760	COG1609	Transcriptional regulator
H8S71_16765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_16770	COG0583	DNA-binding transcription factor activity
H8S71_16775	COG0697	spore germination
H8S71_16780	COG1113	amino acid transport
H8S71_16785	COG3858	chitin binding
H8S71_16790	COG1556	Lactate utilization protein
H8S71_16795	COG1139	Iron-sulfur cluster binding protein
H8S71_16800	COG0247	lactate metabolic process
H8S71_16805	COG2197	response regulator
H8S71_16810	COG4585	Histidine kinase
H8S71_16815	COG0842	Transport permease protein
H8S71_16820	COG1131	(ABC) transporter
H8S71_16825	COG0596	Alpha beta hydrolase
H8S71_16830	COG2208	phosphoserine phosphatase activity
H8S71_16835	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H8S71_16840	COG1874	Beta-galactosidase
H8S71_16845	COG3833	ABC-type maltose transport systems, permease component
H8S71_16850	COG1175	transmembrane transport
H8S71_16855	COG2182	Extracellular solute-binding protein
H8S71_16860	COG1609	Transcriptional regulator
H8S71_16865	COG2186	Transcriptional regulator
H8S71_16870	COG1620	l-lactate permease
H8S71_16875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H8S71_16885	COG5039	Polysaccharide pyruvyl transferase
H8S71_16890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8S71_16895	COG0110	maltose O-acetyltransferase activity
H8S71_16900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8S71_16905	COG2244	polysaccharide biosynthetic process
H8S71_16910	COG1216	Glycosyl transferase, family 2
H8S71_16915	COG5039	Polysaccharide pyruvyl transferase
H8S71_16920	COG1216	Glycosyl transferase, family 2
H8S71_16930	COG0438	transferase activity, transferring glycosyl groups
H8S71_16935	COG1215	transferase activity, transferring glycosyl groups
H8S71_16940	COG0438	transferase activity, transferring glycosyl groups
H8S71_16945	COG1086	Polysaccharide biosynthesis protein
H8S71_16950	COG0489	protein tyrosine kinase activity
H8S71_16955	COG3944	biosynthesis protein
H8S71_16960	COG1396	sequence-specific DNA binding
H8S71_16965	COG2272	Belongs to the type-B carboxylesterase lipase family
H8S71_16975	COG3479	Phenolic acid decarboxylase
H8S71_16985	COG1794	racemase activity, acting on amino acids and derivatives
H8S71_16990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8S71_17000	COG1621	beta-fructofuranosidase activity
H8S71_17005	COG1621	beta-fructofuranosidase activity
H8S71_17010	COG0531	amino acid
H8S71_17015	COG1309	transcriptional regulator
H8S71_17020	COG2076	Multidrug Resistance protein
H8S71_17025	COG2076	Multidrug Resistance protein
H8S71_17040	COG0740	serine-type endopeptidase activity
H8S71_17045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8S71_17050	COG0366	Alpha amylase catalytic
H8S71_17055	COG1554	hydrolase, family 65, central catalytic
H8S71_17060	COG5521	maltodextrose utilization protein MalA
H8S71_17065	COG3833	ABC-type maltose transport systems, permease component
H8S71_17070	COG1175	transmembrane transport
H8S71_17075	COG2182	Extracellular solute-binding protein
H8S71_17080	COG0366	Alpha amylase catalytic
H8S71_17085	COG1609	Transcriptional regulator
H8S71_17090	COG1611	Belongs to the LOG family
H8S71_17095	COG1694	Mazg nucleotide pyrophosphohydrolase
H8S71_17100	COG0659	secondary active sulfate transmembrane transporter activity
H8S71_17105	COG0288	reversible hydration of carbon dioxide
H8S71_17110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8S71_17115	COG0577	efflux transmembrane transporter activity
H8S71_17120	COG1136	(ABC) transporter
H8S71_17125	COG5002	protein histidine kinase activity
H8S71_17130	COG0745	RESPONSE REGULATOR receiver
H8S71_17140	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H8S71_17145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_17150	COG1481	regulation of sporulation
H8S71_17155	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H8S71_17160	COG1660	Displays ATPase and GTPase activities
H8S71_17165	COG1051	belongs to the nudix hydrolase family
H8S71_17170	COG0492	ferredoxin-NADP+ reductase activity
H8S71_17175	COG0791	NLP P60 protein
H8S71_17175	COG3883	PFAM NLP P60 protein
H8S71_17180	COG0457	Tetratricopeptide repeat
H8S71_17185	COG1132	(ABC) transporter
H8S71_17220	COG0140	phosphoribosyl-ATP diphosphatase activity
H8S71_17220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8S71_17225	COG0107	imidazoleglycerol-phosphate synthase activity
H8S71_17230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8S71_17235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8S71_17240	COG0131	Imidazoleglycerol-phosphate dehydratase
H8S71_17245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8S71_17250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8S71_17255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H8S71_17260	COG4990	cell redox homeostasis
H8S71_17265	COG5297	Belongs to the glycosyl hydrolase family 6
H8S71_17270	COG0110	maltose O-acetyltransferase activity
H8S71_17275	COG0546	phosphoglycolate phosphatase activity
H8S71_17280	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H8S71_17285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8S71_17290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8S71_17295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8S71_17300	COG0363	glucosamine-6-phosphate deaminase activity
H8S71_17305	COG2188	Transcriptional regulator
H8S71_17310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H8S71_17315	COG1950	PFAM Membrane protein of
H8S71_17320	COG1983	PspC domain protein
H8S71_17325	COG3595	metallopeptidase activity
H8S71_17340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8S71_17345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8S71_17350	COG0556	nucleotide-excision repair
H8S71_17355	COG4897	Protein conserved in bacteria
H8S71_17360	COG0574	Belongs to the PEP-utilizing enzyme family
H8S71_17360	COG3848	Pyruvate phosphate dikinase
H8S71_17365	COG1309	transcriptional regulator
H8S71_17370	COG2814	Major facilitator Superfamily
H8S71_17375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8S71_17385	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_17385	COG0793	Belongs to the peptidase S41A family
H8S71_17390	COG2177	Part of the ABC transporter FtsEX involved in
H8S71_17395	COG2884	Cell division ATP-binding protein ftsE
H8S71_17400	COG2010	Cytochrome c
H8S71_17405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_17415	COG0653	protein targeting
H8S71_17420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8S71_17435	COG1516	flagellar protein fliS
H8S71_17440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8S71_17445	COG1334	flagellar protein FlaG
H8S71_17450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8S71_17455	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8S71_17460	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H8S71_17470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8S71_17475	COG1256	bacterial-type flagellum assembly
H8S71_17475	COG4786	Flagellar basal body rod
H8S71_17480	COG3418	PFAM FlgN family protein
H8S71_17485	COG2747	anti-sigma28 factor FlgM
H8S71_17495	COG1040	competence protein
H8S71_17505	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H8S71_17510	COG1307	EDD domain protein, DegV family
H8S71_17515	COG2197	response regulator
H8S71_17520	COG4585	Histidine kinase
H8S71_17525	COG1739	Uncharacterized protein family UPF0029
H8S71_17530	COG1316	TRANSCRIPTIONal
H8S71_17535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8S71_17540	COG0438	transferase activity, transferring glycosyl groups
H8S71_17545	COG1215	transferase activity, transferring glycosyl groups
H8S71_17550	COG3206	protein involved in exopolysaccharide biosynthesis
H8S71_17555	COG3307	-O-antigen
H8S71_17560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8S71_17565	COG0438	transferase activity, transferring glycosyl groups
H8S71_17565	COG0297	glycogen (starch) synthase activity
H8S71_17570	COG2244	polysaccharide biosynthetic process
H8S71_17580	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_17580	COG2247	cell wall binding repeat
H8S71_17585	COG2385	sporulation resulting in formation of a cellular spore
H8S71_17585	COG2247	cell wall binding repeat
H8S71_17595	COG1316	TRANSCRIPTIONal
H8S71_17600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H8S71_17605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8S71_17610	COG1134	teichoic acid transport
H8S71_17615	COG1682	transport, permease protein
H8S71_17620	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H8S71_17625	COG0438	transferase activity, transferring glycosyl groups
H8S71_17630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H8S71_17635	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8S71_17640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H8S71_17650	COG4193	domain, Protein
H8S71_17655	COG1482	cell wall glycoprotein biosynthetic process
H8S71_17660	COG0697	spore germination
H8S71_17665	COG0814	amino acid
H8S71_17675	COG2814	Major facilitator Superfamily
H8S71_17680	COG1316	TRANSCRIPTIONal
H8S71_17685	COG0561	phosphatase activity
H8S71_17690	COG0791	NLP P60 protein
H8S71_17700	COG2843	Capsule synthesis protein
H8S71_17710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8S71_17715	COG1609	Transcriptional regulator
H8S71_17720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_17725	COG1869	D-ribose catabolic process
H8S71_17730	COG1129	ABC transporter
H8S71_17735	COG1172	Belongs to the binding-protein-dependent transport system permease family
H8S71_17740	COG1879	ABC-type sugar transport system periplasmic component
H8S71_17745	COG3103	Sh3 type 3 domain protein
H8S71_17755	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8S71_17760	COG3527	Alpha-acetolactate decarboxylase
H8S71_17765	COG0028	Belongs to the TPP enzyme family
H8S71_17770	COG0583	DNA-binding transcription factor activity
H8S71_17775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H8S71_17790	COG5337	Spore coat protein CotH
H8S71_17800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8S71_17810	COG0405	Gamma-glutamyltransferase
H8S71_17815	COG1522	sequence-specific DNA binding
H8S71_17820	COG2059	Chromate
H8S71_17825	COG2059	Chromate
H8S71_17835	COG0655	NAD(P)H dehydrogenase (quinone) activity
H8S71_17840	COG0583	DNA-binding transcription factor activity
H8S71_17860	COG5444	nuclease activity
H8S71_17880	COG3878	Protein conserved in bacteria
H8S71_17885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8S71_17890	COG4464	protein tyrosine phosphatase activity
H8S71_17895	COG0489	protein tyrosine kinase activity
H8S71_17900	COG3944	biosynthesis protein
H8S71_17910	COG4715	Zinc finger, swim domain protein
H8S71_17915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8S71_17920	COG0561	phosphatase activity
H8S71_17925	COG1349	DNA-binding transcription factor activity
H8S71_17930	COG0629	single-stranded DNA binding
H8S71_17945	COG3764	Sortase (surface protein transpeptidase)
H8S71_17955	COG3279	Response regulator of the LytR AlgR family
H8S71_17960	COG0745	RESPONSE REGULATOR receiver
H8S71_17960	COG2972	Histidine kinase
H8S71_17965	COG1970	mechanosensitive ion channel activity
H8S71_17970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8S71_17975	COG0457	Tetratricopeptide repeat
H8S71_17980	COG4786	Flagellar basal body rod
H8S71_17985	COG4786	Flagellar basal body rod
H8S71_17990	COG1077	Cell shape determining protein MreB Mrl
H8S71_17995	COG1609	Transcriptional regulator
H8S71_18005	COG1846	Transcriptional regulator
H8S71_18010	COG2814	Major facilitator Superfamily
H8S71_18015	COG3420	alginic acid biosynthetic process
H8S71_18020	COG1953	Uracil, thiamine, allantoin
H8S71_18025	COG0477	Major facilitator Superfamily
H8S71_18030	COG1335	isochorismatase
H8S71_18040	COG0004	ammonium transporteR
H8S71_18045	COG0347	Belongs to the P(II) protein family
H8S71_18050	COG0671	phosphoesterase, PA-phosphatase related
H8S71_18060	COG0739	heme binding
H8S71_18065	COG1247	-acetyltransferase
H8S71_18085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8S71_18090	COG0789	Transcriptional regulator
H8S71_18100	COG2910	NAD(P)H-binding
H8S71_18105	COG1959	2 iron, 2 sulfur cluster binding
H8S71_18110	COG0804	urea catabolic process
H8S71_18115	COG0832	Belongs to the urease beta subunit family
H8S71_18120	COG0831	urea catabolic process
H8S71_18135	COG3237	CsbD-like
H8S71_18140	COG1994	Peptidase M50
H8S71_18145	COG0457	Tetratricopeptide repeat
H8S71_18150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8S71_18155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8S71_18165	COG2304	oxidoreductase activity
H8S71_18175	COG2304	oxidoreductase activity
H8S71_18180	COG2385	sporulation resulting in formation of a cellular spore
H8S71_18185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8S71_18195	COG4836	Membrane
H8S71_18205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8S71_18210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8S71_18215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8S71_18220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8S71_18225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8S71_18230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8S71_18240	COG0356	it plays a direct role in the translocation of protons across the membrane
H8S71_18250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8S71_18255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8S71_18260	COG4475	Protein of unknown function (DUF436)
H8S71_18265	COG0698	ribose 5-phosphate isomerase
H8S71_18270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8S71_18275	COG1971	Probably functions as a manganese efflux pump
H8S71_18280	COG0009	L-threonylcarbamoyladenylate synthase
H8S71_18285	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H8S71_18305	COG2890	protein-(glutamine-N5) methyltransferase activity
H8S71_18310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8S71_18315	COG0346	lactoylglutathione lyase activity
H8S71_18320	COG0789	Transcriptional regulator
H8S71_18325	COG0679	Auxin Efflux Carrier
H8S71_18330	COG0281	malic enzyme
H8S71_18335	COG1435	thymidine kinase activity
H8S71_18345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8S71_18355	COG1494	fructose-1,6-bisphosphatase
H8S71_18360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8S71_18365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8S71_18370	COG0191	fructose-bisphosphate aldolase activity
H8S71_18375	COG2204	response regulator
H8S71_18380	COG4821	SIS domain
H8S71_18385	COG0504	CTP synthase activity
H8S71_18390	COG3343	RNA polymerase activity
H8S71_18395	COG1960	acyl-CoA dehydrogenase activity
H8S71_18400	COG0247	lactate metabolic process
H8S71_18400	COG2181	nitrate reductase activity
H8S71_18405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8S71_18410	COG4294	response to UV
H8S71_18420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H8S71_18425	COG1132	(ABC) transporter
H8S71_18430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8S71_18440	COG2181	nitrate reductase activity
H8S71_18445	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H8S71_18450	COG1140	nitrate reductase beta subunit
H8S71_18455	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H8S71_18460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8S71_18470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8S71_18475	COG2223	nitrite transmembrane transporter activity
H8S71_18480	COG0018	arginyl-trna synthetase
H8S71_18485	COG4506	Protein conserved in bacteria
H8S71_18500	COG0535	radical SAM domain protein
H8S71_18510	COG1131	(ABC) transporter
H8S71_18515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8S71_18520	COG0612	Peptidase, M16
H8S71_18525	COG0612	Peptidase, M16
H8S71_18535	COG3391	amine dehydrogenase activity
H8S71_18540	COG3391	amine dehydrogenase activity
H8S71_18545	COG0457	Tetratricopeptide repeat
H8S71_18575	COG1131	(ABC) transporter
H8S71_18585	COG0010	Belongs to the arginase family
H8S71_18590	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8S71_18595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8S71_18610	COG1994	Peptidase M50
H8S71_18615	COG1942	4-Oxalocrotonate Tautomerase
H8S71_18620	COG1846	Transcriptional regulator
H8S71_18625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8S71_18630	COG0477	Major facilitator Superfamily
H8S71_18635	COG1959	2 iron, 2 sulfur cluster binding
H8S71_18640	COG3465	dGTPase activity
H8S71_18645	COG1078	dGTPase activity
H8S71_18650	COG4844	belongs to the
H8S71_18660	COG0697	spore germination
H8S71_18665	COG0095	Lipoate-protein ligase
H8S71_18670	COG0583	DNA-binding transcription factor activity
H8S71_18675	COG0280	phosphate acetyltransferase
H8S71_18680	COG3253	May function as heme-dependent peroxidase
H8S71_18685	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_18690	COG0436	Aminotransferase
H8S71_18695	COG2814	Major facilitator Superfamily
H8S71_18700	COG0151	Belongs to the GarS family
H8S71_18705	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_18710	COG1917	Cupin 2, conserved barrel domain protein
H8S71_18715	COG0077	Prephenate dehydratase
H8S71_18720	COG2814	Major facilitator Superfamily
H8S71_18725	COG0833	amino acid
H8S71_18730	COG4187	Peptidase family M20/M25/M40
H8S71_18735	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_18740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H8S71_18750	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H8S71_18755	COG1091	dTDP-4-dehydrorhamnose reductase activity
H8S71_18760	COG1088	dTDP-glucose 4,6-dehydratase activity
H8S71_18765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H8S71_18770	COG3980	spore coat polysaccharide biosynthesis protein
H8S71_18775	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
H8S71_18780	COG2089	acid synthase
H8S71_18785	COG0456	acetyltransferase
H8S71_18790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8S71_18795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H8S71_18800	COG0463	Glycosyl transferase, family 2
H8S71_18810	COG2363	Small membrane protein
H8S71_18815	COG2233	PERMEase
H8S71_18825	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_18830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8S71_18835	COG1216	Glycosyl transferase, family 2
H8S71_18850	COG1695	Transcriptional regulator
H8S71_18855	COG0351	phosphomethylpyrimidine kinase
H8S71_18865	COG1621	beta-fructofuranosidase activity
H8S71_18870	COG1263	PTS System
H8S71_18870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_18875	COG2116	formate transmembrane transporter activity
H8S71_18880	COG3711	transcriptional antiterminator
H8S71_18890	COG1404	Belongs to the peptidase S8 family
H8S71_18895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_18900	COG0778	Nitroreductase
H8S71_18905	COG0772	Belongs to the SEDS family
H8S71_18920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8S71_18925	COG1845	cytochrome c oxidase, subunit III
H8S71_18930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8S71_18935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8S71_18940	COG2261	transglycosylase associated protein
H8S71_18945	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H8S71_18950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H8S71_18955	COG2246	polysaccharide biosynthetic process
H8S71_18960	COG1309	transcriptional regulator
H8S71_18970	COG3162	membrane
H8S71_18975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_18980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8S71_18985	COG2837	iron assimilation
H8S71_18990	COG2822	iron ion transport
H8S71_18995	COG0672	)-iron permease
H8S71_19000	COG0352	thiamine-phosphate diphosphorylase activity
H8S71_19005	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H8S71_19010	COG0583	DNA-binding transcription factor activity
H8S71_19015	COG1380	Effector of murein hydrolase LrgA
H8S71_19020	COG1346	cytolysis
H8S71_19025	COG2814	Major facilitator Superfamily
H8S71_19030	COG4895	conserved protein (DUF2196)
H8S71_19035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8S71_19040	COG0346	lactoylglutathione lyase activity
H8S71_19050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_19055	COG1404	Belongs to the peptidase S8 family
H8S71_19060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_19060	COG1263	PTS System
H8S71_19065	COG3711	transcriptional antiterminator
H8S71_19070	COG1442	glycosyl transferase family 8
H8S71_19075	COG5522	Integral membrane protein (intg_mem_TP0381)
H8S71_19080	COG1846	Transcriptional regulator
H8S71_19085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8S71_19090	COG2234	aminopeptidase activity
H8S71_19105	COG2814	Major facilitator Superfamily
H8S71_19110	COG2357	RelA SpoT domain protein
H8S71_19115	COG1575	Belongs to the MenA family. Type 1 subfamily
H8S71_19130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_19135	COG1696	Membrane protein involved in D-alanine export
H8S71_19140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_19145	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H8S71_19150	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H8S71_19155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8S71_19160	COG1486	melibiose metabolic process
H8S71_19165	COG1447	Phosphotransferase system cellobiose-specific component IIA
H8S71_19170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_19175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_19180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_19180	COG3711	transcriptional antiterminator
H8S71_19190	COG2094	Belongs to the DNA glycosylase MPG family
H8S71_19195	COG0753	catalase activity
H8S71_19200	COG2814	Major facilitator Superfamily
H8S71_19205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H8S71_19210	COG1131	(ABC) transporter
H8S71_19230	COG1595	DNA-templated transcription, initiation
H8S71_19235	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H8S71_19240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8S71_19245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8S71_19250	COG4988	ABC transporter
H8S71_19255	COG1294	oxidase, subunit
H8S71_19260	COG1271	oxidase subunit
H8S71_19265	COG3493	citrate carrier protein
H8S71_19270	COG0501	Belongs to the peptidase M48B family
H8S71_19280	COG0726	polysaccharide deacetylase
H8S71_19295	COG3842	ATPase activity
H8S71_19300	COG2508	Transcriptional regulator
H8S71_19305	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_19310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_19320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8S71_19330	COG4585	Histidine kinase
H8S71_19335	COG2197	response regulator
H8S71_19340	COG2195	Cleaves the N-terminal amino acid of tripeptides
H8S71_19350	COG4894	glucomannan catabolic process
H8S71_19355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H8S71_19360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H8S71_19365	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_19370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8S71_19375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8S71_19380	COG2610	gluconate transmembrane transporter activity
H8S71_19385	COG0500	methyltransferase
H8S71_19390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8S71_19405	COG0753	catalase activity
H8S71_19405	COG0693	protein deglycase activity
H8S71_19410	COG2851	Citrate transporter
H8S71_19415	COG2273	Hydrolase Family 16
H8S71_19420	COG3711	transcriptional antiterminator
H8S71_19430	COG2270	Major facilitator Superfamily
H8S71_19435	COG0513	Belongs to the DEAD box helicase family
H8S71_19440	COG2755	lipolytic protein G-D-S-L family
H8S71_19440	COG3401	FG-GAP repeat protein
H8S71_19470	COG0697	spore germination
H8S71_19475	COG0589	response to stress
H8S71_19480	COG2723	6-phospho-beta-galactosidase activity
H8S71_19485	COG1263	PTS System
H8S71_19485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_19485	COG2190	(PTS) system
H8S71_19520	COG0494	nUDIX hydrolase
H8S71_19525	COG3507	Belongs to the glycosyl hydrolase 43 family
H8S71_19540	COG2986	histidine ammonia-lyase
H8S71_19545	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8S71_19550	COG1228	amidohydrolase
H8S71_19555	COG0010	Belongs to the arginase family
H8S71_19560	COG0833	amino acid
H8S71_19565	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H8S71_19570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8S71_19575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H8S71_19580	COG2390	Transcriptional regulator
H8S71_19590	COG3192	ethanolamine utilization protein
H8S71_19595	COG2079	MmgE PrpD family protein
H8S71_19600	COG1473	amidohydrolase
H8S71_19605	COG1126	abc transporter atp-binding protein
H8S71_19610	COG0765	amino acid transport
H8S71_19615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_19620	COG0456	acetyltransferase
H8S71_19625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_19630	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H8S71_19635	COG0561	phosphatase activity
H8S71_19665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_19670	COG5294	Protein conserved in bacteria
H8S71_19675	COG0577	efflux transmembrane transporter activity
H8S71_19680	COG1136	(ABC) transporter
H8S71_19685	COG2205	protein histidine kinase activity
H8S71_19690	COG0745	RESPONSE REGULATOR receiver
H8S71_19695	COG0191	fructose-bisphosphate aldolase activity
H8S71_19700	COG1082	Xylose isomerase domain protein TIM barrel
H8S71_19705	COG1082	Xylose isomerase domain protein TIM barrel
H8S71_19710	COG0673	inositol 2-dehydrogenase activity
H8S71_19715	COG2814	Major facilitator Superfamily
H8S71_19720	COG1082	Xylose isomerase domain protein TIM barrel
H8S71_19725	COG3962	Belongs to the TPP enzyme family
H8S71_19730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_19740	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_19745	COG1349	DNA-binding transcription factor activity
H8S71_19750	COG0667	Aldo Keto reductase
H8S71_19765	COG2814	Major facilitator Superfamily
H8S71_19770	COG0326	Molecular chaperone. Has ATPase activity
H8S71_19780	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_19785	COG1309	transcriptional regulator
H8S71_19790	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_19800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8S71_19810	COG1714	RDD family
H8S71_19815	COG2311	Membrane
H8S71_19820	COG1917	Cupin 2, conserved barrel domain protein
H8S71_19825	COG1309	transcriptional regulator
H8S71_19830	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_19835	COG1846	Transcriptional regulator
H8S71_19840	COG1380	Effector of murein hydrolase LrgA
H8S71_19845	COG1346	cytolysis
H8S71_19850	COG5039	Polysaccharide pyruvyl transferase
H8S71_19855	COG1929	Belongs to the glycerate kinase type-1 family
H8S71_19860	COG1802	Transcriptional regulator
H8S71_19865	COG1070	Carbohydrate kinase
H8S71_19870	COG2610	gluconate transmembrane transporter activity
H8S71_19875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8S71_19880	COG0450	alkyl hydroperoxide reductase
H8S71_19885	COG3634	alkyl hydroperoxide reductase activity
H8S71_19890	COG2723	6-phospho-beta-galactosidase activity
H8S71_19900	COG2188	Transcriptional regulator
H8S71_19915	COG1131	(ABC) transporter
H8S71_19920	COG1994	Peptidase M50
H8S71_19925	COG0535	radical SAM domain protein
H8S71_19935	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H8S71_19970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8S71_19985	COG1063	alcohol dehydrogenase
H8S71_20005	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
H8S71_20010	COG0456	acetyltransferase
H8S71_20015	COG0457	Tetratricopeptide repeat
H8S71_20025	COG0010	Belongs to the arginase family
H8S71_20030	COG0833	amino acid
H8S71_20035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8S71_20040	COG3829	transcription factor binding
H8S71_20055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8S71_20060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8S71_20065	COG4853	Protein conserved in bacteria
H8S71_20070	COG4863	YycH protein
H8S71_20075	COG5002	protein histidine kinase activity
H8S71_20080	COG0745	RESPONSE REGULATOR receiver
H8S71_20110	COG0346	lactoylglutathione lyase activity
H8S71_20115	COG0305	Participates in initiation and elongation during chromosome replication
H8S71_20130	COG3093	addiction module antidote protein HigA
H8S71_20135	COG2807	transmembrane transport
H8S71_20140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H8S71_20145	COG0359	binds to the 23S rRNA
H8S71_20150	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H8S71_20155	COG4241	membrane
H8S71_20165	COG5577	PFAM Coat F domain
H8S71_20170	COG1733	regulation of RNA biosynthetic process
H8S71_20175	COG1227	inorganic diphosphatase activity
H8S71_20185	COG2271	Major facilitator Superfamily
H8S71_20190	COG4978	Transcriptional regulator
H8S71_20190	COG0789	Transcriptional regulator
H8S71_20200	COG4319	ketosteroid isomerase
H8S71_20205	COG1357	PFAM Pentapeptide repeats (8 copies)
H8S71_20210	COG2814	Major facilitator Superfamily
H8S71_20215	COG0583	DNA-binding transcription factor activity
H8S71_20220	COG2153	protein acetylation
H8S71_20230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_20235	COG1846	Transcriptional regulator
H8S71_20240	COG2153	protein acetylation
H8S71_20245	COG2364	Membrane
H8S71_20250	COG0456	acetyltransferase
H8S71_20255	COG2315	Protein conserved in bacteria
H8S71_20260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H8S71_20270	COG2814	Major facilitator Superfamily
H8S71_20280	COG1331	Highly conserved protein containing a thioredoxin domain
H8S71_20285	COG1266	CAAX protease self-immunity
H8S71_20290	COG0477	Major facilitator Superfamily
H8S71_20290	COG2814	Major facilitator Superfamily
H8S71_20295	COG0110	maltose O-acetyltransferase activity
H8S71_20300	COG0346	lactoylglutathione lyase activity
H8S71_20305	COG1609	Transcriptional regulator
H8S71_20310	COG0708	Exodeoxyribonuclease III
H8S71_20315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8S71_20320	COG0629	single-stranded DNA binding
H8S71_20325	COG0360	Binds together with S18 to 16S ribosomal RNA
H8S71_20330	COG0012	GTP binding
H8S71_20335	COG0243	molybdopterin cofactor binding
H8S71_20340	COG4481	Protein conserved in bacteria
H8S71_20345	COG3949	Membrane
H8S71_20355	COG1475	DNA binding
H8S71_20360	COG1192	Involved in chromosome partitioning
H8S71_20370	COG1475	DNA binding
H8S71_20375	COG0357	Ribosomal RNA small subunit methyltransferase G
H8S71_20380	COG0445	tRNA wobble uridine modification
H8S71_20385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8S71_20390	COG1847	R3H domain protein
H8S71_20395	COG0706	membrane insertase activity
H8S71_20400	COG0594	ribonuclease P activity