locus-tag	class	description
S100333_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S100333_00002	COG0592	DNA-directed DNA polymerase activity
S100333_00003	COG2501	S4 domain
S100333_00004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S100333_00006	COG0187	DNA topoisomerase II activity
S100333_00007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100333_00014	COG0516	GMP reductase activity
S100333_00014	COG0517	IMP dehydrogenase activity
S100333_00015	COG1686	Belongs to the peptidase S11 family
S100333_00016	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
S100333_00017	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
S100333_00018	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S100333_00020	COG1428	Deoxynucleoside kinase
S100333_00021	COG1428	Deoxynucleoside kinase
S100333_00022	COG3858	chitin binding
S100333_00022	COG1388	LysM domain
S100333_00023	COG1335	isochorismatase
S100333_00024	COG0590	tRNA wobble adenosine to inosine editing
S100333_00025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S100333_00026	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S100333_00027	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S100333_00036	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
S100333_00037	COG3853	Toxic anion resistance protein (TelA)
S100333_00038	COG1982	Orn Lys Arg decarboxylase major
S100333_00039	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S100333_00040	COG3870	Protein conserved in bacteria
S100333_00041	COG1728	Protein conserved in bacteria
S100333_00042	COG0470	DNA polymerase III
S100333_00043	COG1774	PSP1 C-terminal conserved region
S100333_00044	COG4467	Involved in initiation control of chromosome replication
S100333_00045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S100333_00046	COG2827	Endonuclease containing a URI domain
S100333_00047	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S100333_00048	COG2801	Transposase and inactivated derivatives
S100333_00050	COG2002	toxin-antitoxin pair type II binding
S100333_00051	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_00051	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_00052	COG0084	hydrolase, TatD family'
S100333_00053	COG3584	3D domain protein
S100333_00053	COG3583	domain protein
S100333_00054	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100333_00055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S100333_00057	COG4466	Protein conserved in bacteria
S100333_00059	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S100333_00060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100333_00061	COG0251	oxidation-reduction process
S100333_00062	COG2088	sporulation resulting in formation of a cellular spore
S100333_00063	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S100333_00064	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S100333_00065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S100333_00066	COG0193	aminoacyl-tRNA hydrolase activity
S100333_00068	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S100333_00069	COG2002	toxin-antitoxin pair type II binding
S100333_00070	COG2244	polysaccharide biosynthetic process
S100333_00071	COG3956	TIGRFAM MazG family protein
S100333_00072	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S100333_00075	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S100333_00076	COG1098	S1 RNA binding domain
S100333_00079	COG2208	phosphoserine phosphatase activity
S100333_00080	COG2304	oxidoreductase activity
S100333_00081	COG0515	serine threonine protein kinase
S100333_00082	COG0037	tRNA processing
S100333_00084	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100333_00085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S100333_00086	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S100333_00087	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100333_00088	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100333_00089	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100333_00090	COG0512	Glutamine amidotransferase of anthranilate synthase
S100333_00091	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100333_00092	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S100333_00093	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S100333_00094	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S100333_00095	COG1396	sequence-specific DNA binding
S100333_00096	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100333_00097	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S100333_00113	COG4463	regulation of RNA biosynthetic process
S100333_00114	COG3880	PFAM UvrB UvrC protein
S100333_00115	COG3869	Catalyzes the specific phosphorylation of arginine residues in
S100333_00116	COG0542	response to heat
S100333_00117	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S100333_00118	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S100333_00119	COG4956	integral membrane protein (PIN domain superfamily)
S100333_00120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S100333_00121	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S100333_00122	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S100333_00123	COG1045	serine acetyltransferase
S100333_00124	COG0215	cysteine-tRNA ligase activity
S100333_00125	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S100333_00126	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100333_00127	COG3688	RNA-binding protein containing a PIN domain
S100333_00128	COG1595	DNA-templated transcription, initiation
S100333_00129	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100333_00130	COG0250	Participates in transcription elongation, termination and antitermination
S100333_00131	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S100333_00132	COG0081	regulation of translation
S100333_00133	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S100333_00134	COG0222	ribosome binding
S100333_00135	COG2813	Specifically methylates the guanine in position
S100333_00136	COG0085	RNA polymerase activity
S100333_00137	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S100333_00138	COG1358	cellular component organization or biogenesis
S100333_00139	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S100333_00140	COG0049	tRNA binding
S100333_00141	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S100333_00142	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S100333_00143	COG0596	Alpha beta hydrolase
S100333_00144	COG0051	transcription antitermination factor activity, RNA binding
S100333_00145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S100333_00146	COG0088	Forms part of the polypeptide exit tunnel
S100333_00147	COG0089	rRNA binding
S100333_00148	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S100333_00149	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S100333_00150	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S100333_00151	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S100333_00152	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S100333_00153	COG0255	Belongs to the universal ribosomal protein uL29 family
S100333_00154	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S100333_00155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S100333_00157	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S100333_00159	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S100333_00160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S100333_00161	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S100333_00163	COG1841	ribosomal large subunit assembly
S100333_00164	COG0200	Binds to the 23S rRNA
S100333_00165	COG0201	protein transport
S100333_00166	COG0563	adenylate kinase activity
S100333_00167	COG0024	Methionine aminopeptidase
S100333_00168	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S100333_00169	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S100333_00170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S100333_00171	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S100333_00172	COG0202	RNA polymerase activity
S100333_00173	COG0203	ribosomal protein L17
S100333_00174	COG1122	ATPase activity
S100333_00175	COG1122	ATPase activity
S100333_00176	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100333_00177	COG0101	tRNA pseudouridine synthase activity
S100333_00178	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S100333_00179	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S100333_00180	COG2226	methyltransferase
S100333_00182	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_00183	COG0489	protein tyrosine kinase activity
S100333_00185	COG2194	sulfuric ester hydrolase activity
S100333_00186	COG0726	polysaccharide deacetylase
S100333_00202	COG0659	secondary active sulfate transmembrane transporter activity
S100333_00203	COG2801	Transposase and inactivated derivatives
S100333_00205	COG0385	Bile acid
S100333_00206	COG2819	hydrolase of the alpha beta superfamily
S100333_00207	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_00208	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_00209	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_00210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_00210	COG2207	Transcriptional regulator
S100333_00211	COG3876	Protein conserved in bacteria
S100333_00212	COG1472	Belongs to the glycosyl hydrolase 3 family
S100333_00213	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100333_00214	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_00214	COG1263	PTS System
S100333_00215	COG1737	Transcriptional regulator
S100333_00216	COG1737	Transcriptional regulator
S100333_00217	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S100333_00218	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_00219	COG1683	Conserved Protein
S100333_00225	COG1595	DNA-templated transcription, initiation
S100333_00226	COG5662	AntiSigma factor
S100333_00227	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S100333_00228	COG4856	YbbR-like protein
S100333_00229	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100333_00230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S100333_00231	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S100333_00232	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S100333_00233	COG2169	Transcriptional regulator
S100333_00234	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100333_00235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100333_00236	COG3002	Belongs to the UPF0753 family
S100333_00237	COG0288	reversible hydration of carbon dioxide
S100333_00240	COG5609	conserved protein (DUF2294)
S100333_00241	COG0745	RESPONSE REGULATOR receiver
S100333_00242	COG0642	Histidine kinase
S100333_00244	COG0515	serine threonine protein kinase
S100333_00247	COG1113	amino acid transport
S100333_00252	COG2602	Beta-lactamase
S100333_00253	COG2124	cytochrome p450
S100333_00255	COG0531	amino acid
S100333_00256	COG0584	glycerophosphoryl diester phosphodiesterase
S100333_00257	COG2271	Major facilitator Superfamily
S100333_00259	COG1846	Transcriptional regulator
S100333_00259	COG0456	acetyltransferase
S100333_00260	COG2271	Major facilitator Superfamily
S100333_00261	COG2271	Major facilitator Superfamily
S100333_00264	COG3409	Peptidoglycan-binding domain 1 protein
S100333_00265	COG0697	spore germination
S100333_00266	COG1917	Cupin 2, conserved barrel domain protein
S100333_00266	COG2207	Transcriptional regulator
S100333_00269	COG1388	LysM domain
S100333_00269	COG3942	CHAP domain
S100333_00271	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
S100333_00272	COG3591	Belongs to the peptidase S1B family
S100333_00274	COG0596	Alpha beta hydrolase
S100333_00275	COG1183	phosphatidylcholine synthase activity
S100333_00276	COG0586	Pfam SNARE associated Golgi protein
S100333_00277	COG0688	phosphatidylethanolamine metabolic process
S100333_00281	COG1301	dicarboxylic acid transport
S100333_00282	COG1263	PTS System
S100333_00282	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_00282	COG2190	(PTS) system
S100333_00283	COG0363	glucosamine-6-phosphate deaminase activity
S100333_00286	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100333_00287	COG0833	amino acid
S100333_00288	COG2040	homocysteine
S100333_00290	COG1115	amino acid carrier protein
S100333_00291	COG1115	amino acid carrier protein
S100333_00292	COG2066	Belongs to the glutaminase family
S100333_00293	COG4191	Histidine kinase
S100333_00294	COG0784	Response regulator, receiver
S100333_00295	COG0784	Response regulator, receiver
S100333_00296	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100333_00297	COG1012	belongs to the aldehyde dehydrogenase family
S100333_00298	COG2271	Major facilitator Superfamily
S100333_00299	COG4948	Mandelate Racemase Muconate Lactonizing
S100333_00300	COG2186	Transcriptional regulator
S100333_00301	COG2721	sulfolactate sulfo-lyase activity
S100333_00302	COG3173	Aminoglycoside phosphotransferase
S100333_00304	COG0697	spore germination
S100333_00305	COG0745	RESPONSE REGULATOR receiver
S100333_00306	COG2205	protein histidine kinase activity
S100333_00307	COG1131	(ABC) transporter
S100333_00310	COG3773	Cell wall hydrolase
S100333_00311	COG2304	oxidoreductase activity
S100333_00312	COG3540	Alkaline phosphatase
S100333_00313	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100333_00314	COG0805	protein transport
S100333_00315	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
S100333_00316	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100333_00317	COG0477	Major facilitator Superfamily
S100333_00318	COG1309	transcriptional regulator
S100333_00319	COG0252	asparaginase activity
S100333_00320	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S100333_00321	COG1714	RDD family
S100333_00322	COG3012	SEC-C Motif Domain Protein
S100333_00322	COG1405	negative regulation of cell septum assembly
S100333_00323	COG3290	protein histidine kinase activity
S100333_00324	COG3279	Response regulator of the LytR AlgR family
S100333_00325	COG4555	ABC transporter
S100333_00326	COG1668	transmembrane transport
S100333_00327	COG0667	Aldo Keto reductase
S100333_00329	COG1595	DNA-templated transcription, initiation
S100333_00330	COG1595	DNA-templated transcription, initiation
S100333_00331	COG1876	peptidase activity
S100333_00332	COG0457	Tetratricopeptide repeat
S100333_00333	COG0457	Tetratricopeptide repeat
S100333_00334	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_00335	COG0366	Alpha amylase catalytic
S100333_00336	COG0366	Alpha amylase catalytic
S100333_00337	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100333_00338	COG1121	(ABC) transporter
S100333_00339	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100333_00340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100333_00341	COG2310	stress, protein
S100333_00342	COG2310	stress, protein
S100333_00343	COG2310	stress, protein
S100333_00344	COG0861	Integral membrane protein TerC family
S100333_00346	COG3853	Toxic anion resistance protein (TelA)
S100333_00348	COG2801	Transposase and inactivated derivatives
S100333_00349	COG0477	Major facilitator Superfamily
S100333_00350	COG2814	Major facilitator Superfamily
S100333_00351	COG0640	Transcriptional regulator
S100333_00352	COG0517	IMP dehydrogenase activity
S100333_00352	COG4175	Glycine betaine
S100333_00353	COG4176	ABC-type proline glycine betaine transport system permease component
S100333_00354	COG2113	Glycine betaine
S100333_00355	COG1473	amidohydrolase
S100333_00356	COG1288	antiporter activity
S100333_00358	COG0366	Alpha amylase catalytic
S100333_00359	COG0366	Alpha amylase catalytic
S100333_00360	COG0039	L-malate dehydrogenase activity
S100333_00361	COG1620	l-lactate permease
S100333_00362	COG1620	l-lactate permease
S100333_00363	COG3403	YqcI/YcgG family
S100333_00364	COG1113	amino acid transport
S100333_00365	COG3665	Urea carboxylase-associated protein
S100333_00366	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S100333_00367	COG1660	Displays ATPase and GTPase activities
S100333_00368	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S100333_00369	COG2801	Transposase and inactivated derivatives
S100333_00371	COG2226	methyltransferase
S100333_00372	COG0583	DNA-binding transcription factor activity
S100333_00373	COG3458	cephalosporin-C deacetylase activity
S100333_00374	COG3541	Predicted nucleotidyltransferase
S100333_00375	COG0506	proline dehydrogenase activity
S100333_00376	COG1012	belongs to the aldehyde dehydrogenase family
S100333_00377	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_00378	COG2508	Transcriptional regulator
S100333_00379	COG3689	TIGRFAM TIGR03943 family protein
S100333_00380	COG0701	Predicted permease
S100333_00381	COG2267	carboxylic ester hydrolase activity
S100333_00382	COG0492	ferredoxin-NADP+ reductase activity
S100333_00383	COG1587	Uroporphyrinogen-III synthase
S100333_00383	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100333_00384	COG2146	nitrite reductase [NAD(P)H] activity
S100333_00385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100333_00386	COG0243	molybdopterin cofactor binding
S100333_00387	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100333_00388	COG2223	nitrite transmembrane transporter activity
S100333_00389	COG1469	GTP cyclohydrolase I activity
S100333_00390	COG1376	ErfK ybiS ycfS ynhG family protein
S100333_00391	COG0523	cobalamin synthesis protein
S100333_00392	COG0523	cobalamin synthesis protein
S100333_00393	COG0765	amino acid transport
S100333_00394	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_00397	COG1714	RDD family
S100333_00399	COG1846	Transcriptional regulator
S100333_00403	COG2723	6-phospho-beta-galactosidase activity
S100333_00404	COG2723	6-phospho-beta-galactosidase activity
S100333_00405	COG2723	6-phospho-beta-galactosidase activity
S100333_00407	COG3209	COG3209 Rhs family protein
S100333_00408	COG3290	protein histidine kinase activity
S100333_00408	COG0840	transmembrane signaling receptor activity
S100333_00409	COG0840	transmembrane signaling receptor activity
S100333_00409	COG3290	protein histidine kinase activity
S100333_00410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S100333_00411	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
S100333_00412	COG1733	regulation of RNA biosynthetic process
S100333_00413	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_00414	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_00415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_00416	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S100333_00417	COG2814	Major facilitator Superfamily
S100333_00419	COG0697	spore germination
S100333_00420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_00422	COG2364	Membrane
S100333_00423	COG1126	abc transporter atp-binding protein
S100333_00424	COG0765	amino acid transport
S100333_00425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_00426	COG0583	DNA-binding transcription factor activity
S100333_00427	COG0163	prenyltransferase activity
S100333_00428	COG0596	Alpha beta hydrolase
S100333_00429	COG3104	oligopeptide transport
S100333_00430	COG5434	Belongs to the glycosyl hydrolase 28 family
S100333_00432	COG0697	spore germination
S100333_00434	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S100333_00435	COG1136	(ABC) transporter
S100333_00436	COG0577	efflux transmembrane transporter activity
S100333_00437	COG0577	efflux transmembrane transporter activity
S100333_00438	COG0745	RESPONSE REGULATOR receiver
S100333_00439	COG0745	RESPONSE REGULATOR receiver
S100333_00440	COG5002	protein histidine kinase activity
S100333_00440	COG3850	Histidine kinase
S100333_00441	COG0457	Tetratricopeptide repeat
S100333_00445	COG0527	aspartate kinase activity
S100333_00447	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_00448	COG4605	iron ion homeostasis
S100333_00449	COG4604	ABC transporter, ATP-binding protein
S100333_00450	COG4607	ABC-type enterochelin transport system periplasmic component
S100333_00453	COG2814	Major facilitator Superfamily
S100333_00454	COG1309	transcriptional regulator
S100333_00455	COG0778	Nitroreductase
S100333_00456	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100333_00457	COG0640	Transcriptional regulator
S100333_00458	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_00459	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S100333_00460	COG1012	belongs to the aldehyde dehydrogenase family
S100333_00461	COG4975	Glucose uptake
S100333_00462	COG4975	Glucose uptake
S100333_00463	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_00464	COG4549	nuclear export factor GLE1
S100333_00465	COG1276	copper resistance
S100333_00465	COG2372	response to copper ion
S100333_00466	COG1349	DNA-binding transcription factor activity
S100333_00468	COG2213	PTS system mannitol-specific
S100333_00469	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_00470	COG0246	Mannitol dehydrogenase
S100333_00471	COG0473	3-isopropylmalate dehydrogenase activity
S100333_00473	COG0681	Belongs to the peptidase S26 family
S100333_00474	COG0412	Dienelactone hydrolase
S100333_00475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100333_00477	COG0561	phosphatase activity
S100333_00478	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S100333_00479	COG1914	H( )-stimulated, divalent metal cation uptake system
S100333_00480	COG4336	lyase activity
S100333_00481	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S100333_00482	COG1984	allophanate hydrolase subunit 2
S100333_00483	COG1414	Transcriptional regulator
S100333_00484	COG2755	lipolytic protein G-D-S-L family
S100333_00486	COG2329	Antibiotic biosynthesis monooxygenase
S100333_00487	COG0768	penicillin binding
S100333_00488	COG4989	oxidoreductase activity
S100333_00489	COG3711	transcriptional antiterminator
S100333_00490	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_00491	COG2226	methyltransferase
S100333_00492	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_00493	COG1917	Cupin 2, conserved barrel domain protein
S100333_00494	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_00495	COG3871	stress protein (general stress protein 26)
S100333_00497	COG2814	Major facilitator Superfamily
S100333_00498	COG1522	sequence-specific DNA binding
S100333_00499	COG0551	DNA topoisomerase type I activity
S100333_00499	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100333_00500	COG0494	nUDIX hydrolase
S100333_00501	COG0028	Belongs to the TPP enzyme family
S100333_00506	COG1914	H( )-stimulated, divalent metal cation uptake system
S100333_00507	COG2261	transglycosylase associated protein
S100333_00508	COG4876	unkown
S100333_00509	COG2217	Heavy metal translocating P-type atpase
S100333_00510	COG3729	General stress protein
S100333_00511	COG0662	Cupin 2, conserved barrel domain protein
S100333_00512	COG2329	Antibiotic biosynthesis monooxygenase
S100333_00513	COG3546	catalase activity
S100333_00514	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S100333_00515	COG3290	protein histidine kinase activity
S100333_00516	COG4565	transcriptional regulatory protein
S100333_00517	COG1301	dicarboxylic acid transport
S100333_00518	COG0628	permease
S100333_00520	COG1131	(ABC) transporter
S100333_00521	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100333_00523	COG1960	acyl-CoA dehydrogenase activity
S100333_00527	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100333_00528	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_00529	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100333_00530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S100333_00531	COG0513	Belongs to the DEAD box helicase family
S100333_00532	COG3402	PFAM membrane-flanked domain
S100333_00533	COG3428	Bacterial PH domain
S100333_00534	COG0705	Rhomboid family
S100333_00535	COG0736	holo-[acyl-carrier-protein] synthase activity
S100333_00536	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S100333_00537	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100333_00538	COG0864	Transcriptional regulator
S100333_00539	COG2337	Toxic component of a toxin-antitoxin (TA) module
S100333_00540	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_00541	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_00542	COG2172	sigma factor antagonist activity
S100333_00543	COG2208	phosphoserine phosphatase activity
S100333_00544	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_00545	COG2172	sigma factor antagonist activity
S100333_00546	COG1191	sigma factor activity
S100333_00547	COG2208	phosphoserine phosphatase activity
S100333_00548	COG2183	response to ionizing radiation
S100333_00549	COG3091	SprT-like family
S100333_00558	COG0583	DNA-binding transcription factor activity
S100333_00559	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_00561	COG5444	nuclease activity
S100333_00564	COG5444	nuclease activity
S100333_00565	COG1476	TRANSCRIPTIONal
S100333_00570	COG0693	protein deglycase activity
S100333_00571	COG1278	Cold shock
S100333_00572	COG1329	Transcriptional regulator
S100333_00574	COG0697	spore germination
S100333_00575	COG2207	Transcriptional regulator
S100333_00575	COG1917	Cupin 2, conserved barrel domain protein
S100333_00576	COG0697	spore germination
S100333_00577	COG2207	Transcriptional regulator
S100333_00577	COG3708	Transcriptional regulator
S100333_00578	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_00579	COG0477	Major facilitator Superfamily
S100333_00580	COG0477	Major facilitator Superfamily
S100333_00582	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
S100333_00585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_00586	COG1309	transcriptional regulator
S100333_00587	COG0697	spore germination
S100333_00588	COG0697	spore germination
S100333_00589	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_00590	COG2030	dehydratase
S100333_00591	COG3545	Serine hydrolase
S100333_00592	COG1733	regulation of RNA biosynthetic process
S100333_00593	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_00594	COG0640	Transcriptional regulator
S100333_00595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S100333_00596	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_00597	COG0697	spore germination
S100333_00598	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_00599	COG0076	glutamate decarboxylase activity
S100333_00600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100333_00601	COG0640	Transcriptional regulator
S100333_00602	COG4585	Histidine kinase
S100333_00603	COG2197	response regulator
S100333_00604	COG2409	Drug exporters of the RND superfamily
S100333_00605	COG0596	Alpha beta hydrolase
S100333_00606	COG1811	Na channel or pump
S100333_00607	COG0789	Transcriptional regulator
S100333_00607	COG4978	Transcriptional regulator
S100333_00608	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100333_00609	COG0778	Nitroreductase
S100333_00610	COG0346	lactoylglutathione lyase activity
S100333_00611	COG2259	Doxx family
S100333_00612	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_00616	COG2323	membrane
S100333_00617	COG2323	membrane
S100333_00618	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_00621	COG1309	transcriptional regulator
S100333_00623	COG0456	acetyltransferase
S100333_00625	COG1113	amino acid transport
S100333_00626	COG2318	DinB family
S100333_00627	COG1846	Transcriptional regulator
S100333_00628	COG1033	growth of symbiont in host cell
S100333_00628	COG2409	Drug exporters of the RND superfamily
S100333_00629	COG0778	Nitroreductase
S100333_00630	COG1846	Transcriptional regulator
S100333_00631	COG2814	Major facilitator Superfamily
S100333_00632	COG0730	response to heat
S100333_00633	COG1802	Transcriptional regulator
S100333_00634	COG1388	LysM domain
S100333_00634	COG3858	chitin binding
S100333_00635	COG1819	glycosyl
S100333_00637	COG1785	Belongs to the alkaline phosphatase family
S100333_00638	COG5646	InterPro IPR014922
S100333_00640	COG0454	-acetyltransferase
S100333_00641	COG1078	dGTPase activity
S100333_00642	COG1388	LysM domain
S100333_00643	COG2814	Major facilitator Superfamily
S100333_00644	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_00645	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100333_00646	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_00647	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_00648	COG2723	6-phospho-beta-galactosidase activity
S100333_00649	COG2188	Transcriptional regulator
S100333_00650	COG1940	carbohydrate kinase activity
S100333_00651	COG1482	cell wall glycoprotein biosynthetic process
S100333_00652	COG4124	Belongs to the glycosyl hydrolase 26 family
S100333_00661	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S100333_00662	COG0802	atpase or kinase
S100333_00663	COG1214	PFAM Peptidase M22, glycoprotease
S100333_00664	COG0456	acetyltransferase
S100333_00665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S100333_00667	COG0488	(ABC) transporter
S100333_00668	COG0315	cyclic pyranopterin monophosphate synthase activity
S100333_00669	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S100333_00670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100333_00671	COG0805	protein transport
S100333_00673	COG1266	CAAX protease self-immunity
S100333_00674	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S100333_00675	COG0459	protein refolding
S100333_00676	COG0745	RESPONSE REGULATOR receiver
S100333_00678	COG3290	protein histidine kinase activity
S100333_00693	COG0457	Tetratricopeptide repeat
S100333_00694	COG0457	Tetratricopeptide repeat
S100333_00695	COG1063	alcohol dehydrogenase
S100333_00696	COG2211	Major facilitator Superfamily
S100333_00697	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_00698	COG1842	Phage shock protein A
S100333_00699	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100333_00700	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S100333_00701	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S100333_00702	COG4260	virion core protein, lumpy skin disease virus
S100333_00705	COG2814	Major facilitator Superfamily
S100333_00706	COG1063	alcohol dehydrogenase
S100333_00707	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S100333_00708	COG0823	Involved in the tonB-independent uptake of proteins
S100333_00709	COG2801	Transposase and inactivated derivatives
S100333_00712	COG2267	carboxylic ester hydrolase activity
S100333_00714	COG2132	Multicopper oxidase
S100333_00715	COG1113	amino acid transport
S100333_00716	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100333_00717	COG0714	Associated with various cellular activities
S100333_00718	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S100333_00719	COG1305	Transglutaminase-like
S100333_00720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S100333_00720	COG0519	Catalyzes the synthesis of GMP from XMP
S100333_00723	COG2252	PERMEase
S100333_00724	COG3064	Membrane
S100333_00726	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S100333_00728	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S100333_00729	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S100333_00730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S100333_00731	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S100333_00732	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100333_00733	COG0047	phosphoribosylformylglycinamidine synthase activity
S100333_00734	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100333_00735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S100333_00736	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S100333_00737	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S100333_00738	COG0138	bifunctional purine biosynthesis protein purh
S100333_00739	COG0151	Belongs to the GarS family
S100333_00740	COG1522	sequence-specific DNA binding
S100333_00741	COG0531	amino acid
S100333_00743	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100333_00744	COG1470	cell adhesion involved in biofilm formation
S100333_00745	COG4496	protein, YerC YecD
S100333_00746	COG0069	glutamate synthase activity
S100333_00748	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
S100333_00749	COG0210	DNA helicase
S100333_00750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S100333_00751	COG4851	CamS sex pheromone cAM373 precursor
S100333_00753	COG2801	Transposase and inactivated derivatives
S100333_00754	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_00755	COG1285	pathogenesis
S100333_00756	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_00757	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100333_00758	COG0154	amidase activity
S100333_00759	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100333_00760	COG1309	transcriptional regulator
S100333_00761	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S100333_00762	COG1597	lipid kinase activity
S100333_00763	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100333_00773	COG0457	Tetratricopeptide repeat
S100333_00775	COG0457	Tetratricopeptide repeat
S100333_00779	COG5444	nuclease activity
S100333_00780	COG3391	amine dehydrogenase activity
S100333_00781	COG0457	Tetratricopeptide repeat
S100333_00783	COG0217	transcriptional regulatory protein
S100333_00785	COG1309	transcriptional regulator
S100333_00788	COG3546	catalase activity
S100333_00789	COG0454	-acetyltransferase
S100333_00790	COG5578	integral membrane protein
S100333_00791	COG2972	Histidine kinase
S100333_00792	COG2207	Transcriptional regulator
S100333_00792	COG4753	response regulator
S100333_00793	COG1653	transport
S100333_00794	COG1175	transmembrane transport
S100333_00795	COG0395	ABC-type sugar transport system, permease component
S100333_00796	COG3401	FG-GAP repeat protein
S100333_00797	COG3401	FG-GAP repeat protein
S100333_00798	COG2755	lipolytic protein G-D-S-L family
S100333_00799	COG1874	Beta-galactosidase
S100333_00800	COG1874	Beta-galactosidase
S100333_00801	COG1874	Beta-galactosidase
S100333_00805	COG1653	transport
S100333_00806	COG4209	transmembrane transport
S100333_00807	COG0395	ABC-type sugar transport system, permease component
S100333_00808	COG1486	melibiose metabolic process
S100333_00809	COG2323	membrane
S100333_00811	COG2801	Transposase and inactivated derivatives
S100333_00812	COG3328	transposase activity
S100333_00813	COG2329	Antibiotic biosynthesis monooxygenase
S100333_00814	COG0346	lactoylglutathione lyase activity
S100333_00815	COG0346	lactoylglutathione lyase activity
S100333_00817	COG5583	Uncharacterized small protein (DUF2292)
S100333_00818	COG0670	Belongs to the BI1 family
S100333_00819	COG0697	spore germination
S100333_00820	COG1846	Transcriptional regulator
S100333_00822	COG2801	Transposase and inactivated derivatives
S100333_00824	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100333_00824	COG2124	cytochrome p450
S100333_00825	COG1368	sulfuric ester hydrolase activity
S100333_00826	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S100333_00827	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100333_00828	COG1442	glycosyl transferase family 8
S100333_00829	COG1216	Glycosyl transferase, family 2
S100333_00830	COG1442	glycosyl transferase family 8
S100333_00831	COG2223	nitrite transmembrane transporter activity
S100333_00832	COG1011	Hydrolase
S100333_00833	COG0531	amino acid
S100333_00834	COG1012	belongs to the aldehyde dehydrogenase family
S100333_00835	COG0840	transmembrane signaling receptor activity
S100333_00836	COG0488	(ABC) transporter
S100333_00838	COG0789	Transcriptional regulator
S100333_00839	COG2814	Major facilitator Superfamily
S100333_00842	COG2801	Transposase and inactivated derivatives
S100333_00843	COG0488	(ABC) transporter
S100333_00844	COG0513	Belongs to the DEAD box helicase family
S100333_00845	COG0456	acetyltransferase
S100333_00846	COG3328	transposase activity
S100333_00847	COG2130	NADP-dependent
S100333_00848	COG1120	ATPase activity
S100333_00849	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_00850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_00851	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S100333_00854	COG3866	Pectate lyase
S100333_00855	COG0471	metal ion transport
S100333_00856	COG3290	protein histidine kinase activity
S100333_00857	COG4565	transcriptional regulatory protein
S100333_00858	COG3181	Tripartite tricarboxylate transporter family receptor
S100333_00859	COG2851	Citrate transporter
S100333_00860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_00861	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
S100333_00862	COG1254	Belongs to the acylphosphatase family
S100333_00863	COG2258	MOSC domain
S100333_00867	COG0024	Methionine aminopeptidase
S100333_00868	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_00868	COG1263	PTS System
S100333_00869	COG1368	sulfuric ester hydrolase activity
S100333_00871	COG1115	amino acid carrier protein
S100333_00872	COG0697	spore germination
S100333_00873	COG1263	PTS System
S100333_00873	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_00874	COG0366	Alpha amylase catalytic
S100333_00875	COG2188	Transcriptional regulator
S100333_00876	COG0778	Nitroreductase
S100333_00877	COG0737	Belongs to the 5'-nucleotidase family
S100333_00878	COG0693	protein deglycase activity
S100333_00879	COG2814	Major facilitator Superfamily
S100333_00880	COG4840	Belongs to the UPF0435 family
S100333_00881	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100333_00882	COG4980	gas vesicle protein
S100333_00883	COG1295	ribonuclease BN
S100333_00884	COG0477	Major facilitator Superfamily
S100333_00885	COG0387	Pfam Sodium calcium exchanger
S100333_00887	COG0668	transmembrane transport
S100333_00888	COG0535	radical SAM domain protein
S100333_00890	COG0726	polysaccharide deacetylase
S100333_00891	COG2084	Dehydrogenase
S100333_00892	COG0598	Magnesium transport protein CorA
S100333_00893	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S100333_00894	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100333_00896	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100333_00897	COG4637	Psort location Cytoplasmic, score
S100333_00899	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100333_00900	COG0022	dehydrogenase e1 component
S100333_00901	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100333_00902	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100333_00903	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100333_00904	COG3284	Transcriptional regulator
S100333_00906	COG1742	UPF0060 membrane protein
S100333_00911	COG4842	Belongs to the WXG100 family
S100333_00912	COG1486	melibiose metabolic process
S100333_00913	COG1737	Transcriptional regulator
S100333_00914	COG1263	PTS System
S100333_00914	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_00915	COG1263	PTS System
S100333_00915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_00916	COG5434	Belongs to the glycosyl hydrolase 28 family
S100333_00917	COG1132	(ABC) transporter
S100333_00918	COG1132	(ABC) transporter
S100333_00919	COG2259	Doxx family
S100333_00920	COG2514	catechol 2,3-dioxygenase activity
S100333_00921	COG1917	Cupin 2, conserved barrel domain protein
S100333_00921	COG4977	sequence-specific DNA binding
S100333_00922	COG2814	Major facilitator Superfamily
S100333_00923	COG1082	Xylose isomerase domain protein TIM barrel
S100333_00924	COG0673	inositol 2-dehydrogenase activity
S100333_00925	COG0673	inositol 2-dehydrogenase activity
S100333_00927	COG4585	Histidine kinase
S100333_00928	COG2197	response regulator
S100333_00929	COG1131	(ABC) transporter
S100333_00930	COG1511	domain protein
S100333_00930	COG0842	Transport permease protein
S100333_00931	COG0842	Transport permease protein
S100333_00933	COG1695	Transcriptional regulator
S100333_00934	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S100333_00935	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
S100333_00936	COG1309	transcriptional regulator
S100333_00937	COG2814	Major facilitator Superfamily
S100333_00938	COG2318	DinB family
S100333_00939	COG2814	Major facilitator Superfamily
S100333_00940	COG1846	Transcriptional regulator
S100333_00941	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S100333_00941	COG0392	lysyltransferase activity
S100333_00942	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_00943	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_00944	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_00945	COG0384	phenazine biosynthesis protein PhzF
S100333_00946	COG0778	Nitroreductase
S100333_00949	COG1090	epimerase
S100333_00950	COG2137	regulation of response to DNA damage stimulus
S100333_00953	COG2814	Major facilitator Superfamily
S100333_00957	COG2801	Transposase and inactivated derivatives
S100333_00958	COG3103	Sh3 type 3 domain protein
S100333_00959	COG5658	integral membrane protein
S100333_00960	COG0596	Alpha beta hydrolase
S100333_00961	COG0463	Glycosyl transferase, family 2
S100333_00962	COG4485	Bacterial membrane protein, YfhO
S100333_00963	COG1988	membrane-bound metal-dependent
S100333_00964	COG1194	a g-specific adenine glycosylase
S100333_00966	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_00969	COG3557	Belongs to the UPF0374 family
S100333_00970	COG1132	(ABC) transporter
S100333_00971	COG4129	membrane
S100333_00972	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100333_00973	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S100333_00974	COG0735	belongs to the Fur family
S100333_00996	COG4326	sporulation control protein
S100333_00998	COG3340	Belongs to the peptidase S51 family
S100333_00999	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S100333_01002	COG0753	catalase activity
S100333_01003	COG1116	anion transmembrane transporter activity
S100333_01004	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100333_01005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100333_01006	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100333_01009	COG1476	TRANSCRIPTIONal
S100333_01011	COG3382	B3 4 domain protein
S100333_01012	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S100333_01014	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S100333_01015	COG0789	Transcriptional regulator
S100333_01016	COG1664	Polymer-forming cytoskeletal
S100333_01017	COG1664	Polymer-forming cytoskeletal
S100333_01018	COG2766	serine protein kinase
S100333_01019	COG2718	Belongs to the UPF0229 family
S100333_01020	COG1846	Transcriptional regulator
S100333_01021	COG1566	PFAM secretion protein HlyD family protein
S100333_01022	COG2814	Major facilitator Superfamily
S100333_01023	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100333_01026	COG1725	Transcriptional regulator
S100333_01027	COG1131	(ABC) transporter
S100333_01028	COG1131	(ABC) transporter
S100333_01029	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100333_01030	COG1278	Cold shock
S100333_01031	COG1464	Belongs to the NlpA lipoprotein family
S100333_01032	COG3706	GGDEF domain
S100333_01033	COG1823	symporter activity
S100333_01034	COG5444	nuclease activity
S100333_01039	COG0582	viral genome integration into host DNA
S100333_01049	COG0433	COG0433 Predicted ATPase
S100333_01050	COG0433	COG0433 Predicted ATPase
S100333_01052	COG5644	endopeptidase inhibitor activity
S100333_01053	COG0791	NLP P60 protein
S100333_01053	COG0741	lytic transglycosylase activity
S100333_01057	COG0457	Tetratricopeptide repeat
S100333_01062	COG5577	PFAM Coat F domain
S100333_01063	COG4085	toxin activity
S100333_01063	COG1525	nuclease
S100333_01063	COG0737	Belongs to the 5'-nucleotidase family
S100333_01064	COG3764	Sortase (surface protein transpeptidase)
S100333_01065	COG0564	pseudouridine synthase activity
S100333_01067	COG0517	IMP dehydrogenase activity
S100333_01068	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100333_01069	COG3153	acetyltransferase
S100333_01069	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100333_01070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100333_01071	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
S100333_01072	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100333_01073	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S100333_01074	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S100333_01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100333_01076	COG2203	Gaf domain
S100333_01076	COG4585	Histidine kinase
S100333_01077	COG2197	response regulator
S100333_01078	COG0431	NADPH-dependent FMN reductase
S100333_01081	COG0791	NLP P60 protein
S100333_01081	COG1388	LysM domain
S100333_01082	COG1959	2 iron, 2 sulfur cluster binding
S100333_01083	COG0668	transmembrane transport
S100333_01084	COG2719	SpoVR family
S100333_01085	COG1785	Belongs to the alkaline phosphatase family
S100333_01086	COG1388	LysM domain
S100333_01086	COG0791	NLP P60 protein
S100333_01087	COG0583	DNA-binding transcription factor activity
S100333_01088	COG0372	Belongs to the citrate synthase family
S100333_01089	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_01090	COG0531	amino acid
S100333_01091	COG0733	neurotransmitter:sodium symporter activity
S100333_01092	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_01093	COG0456	acetyltransferase
S100333_01096	COG1595	DNA-templated transcription, initiation
S100333_01097	COG0667	Aldo Keto reductase
S100333_01098	COG0204	Acyl-transferase
S100333_01099	COG1253	flavin adenine dinucleotide binding
S100333_01100	COG0789	Transcriptional regulator
S100333_01101	COG0436	Aminotransferase
S100333_01102	COG0436	Aminotransferase
S100333_01103	COG1253	flavin adenine dinucleotide binding
S100333_01104	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100333_01105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100333_01106	COG0584	glycerophosphoryl diester phosphodiesterase
S100333_01108	COG0668	transmembrane transport
S100333_01109	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S100333_01110	COG0726	polysaccharide deacetylase
S100333_01111	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100333_01112	COG1757	Na H antiporter
S100333_01113	COG0589	response to stress
S100333_01114	COG1132	(ABC) transporter
S100333_01115	COG1132	(ABC) transporter
S100333_01116	COG0702	epimerase
S100333_01119	COG0189	ligase activity
S100333_01120	COG0189	ligase activity
S100333_01121	COG4399	Belongs to the UPF0754 family
S100333_01122	COG3679	Belongs to the UPF0342 family
S100333_01123	COG4335	DNA alkylation repair
S100333_01124	COG0561	phosphatase activity
S100333_01125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100333_01126	COG0475	glutathione-regulated potassium exporter activity
S100333_01127	COG0490	domain, Protein
S100333_01129	COG1024	Enoyl-CoA hydratase
S100333_01131	COG4152	abc transporter atp-binding protein
S100333_01132	COG1668	transmembrane transport
S100333_01133	COG0420	3'-5' exonuclease activity
S100333_01134	COG4717	serine-type aminopeptidase activity
S100333_01135	COG3481	metal-dependent phosphohydrolase, HD sub domain
S100333_01137	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100333_01140	COG1846	Transcriptional regulator
S100333_01141	COG4980	gas vesicle protein
S100333_01144	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S100333_01145	COG0537	adenosine 5'-monophosphoramidase activity
S100333_01146	COG1131	(ABC) transporter
S100333_01147	COG4473	ABC transporter
S100333_01149	COG1473	amidohydrolase
S100333_01150	COG3069	C4-dicarboxylate transmembrane transporter activity
S100333_01152	COG2329	Antibiotic biosynthesis monooxygenase
S100333_01153	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100333_01154	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S100333_01157	COG1309	transcriptional regulator
S100333_01158	COG1511	domain protein
S100333_01159	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100333_01160	COG4377	Putative membrane peptidase family (DUF2324)
S100333_01161	COG1363	Peptidase, m42
S100333_01162	COG4405	Protein conserved in bacteria
S100333_01163	COG1301	dicarboxylic acid transport
S100333_01164	COG1234	tRNA 3'-trailer cleavage
S100333_01165	COG0095	Lipoate-protein ligase
S100333_01166	COG0702	epimerase
S100333_01167	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_01169	COG0501	Belongs to the peptidase M48B family
S100333_01171	COG0456	acetyltransferase
S100333_01172	COG0604	alcohol dehydrogenase
S100333_01173	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S100333_01174	COG0406	alpha-ribazole phosphatase activity
S100333_01175	COG0183	Belongs to the thiolase family
S100333_01176	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_01177	COG1268	BioY protein
S100333_01178	COG0840	transmembrane signaling receptor activity
S100333_01179	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100333_01179	COG0723	plastoquinol--plastocyanin reductase activity
S100333_01180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100333_01180	COG0723	plastoquinol--plastocyanin reductase activity
S100333_01181	COG0723	plastoquinol--plastocyanin reductase activity
S100333_01181	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100333_01182	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_01184	COG4903	ComK protein
S100333_01185	COG4903	ComK protein
S100333_01186	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_01188	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_01191	COG0398	Pfam SNARE associated Golgi protein
S100333_01192	COG0681	Belongs to the peptidase S26 family
S100333_01193	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S100333_01194	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S100333_01195	COG1846	Transcriptional regulator
S100333_01196	COG0738	Major facilitator superfamily
S100333_01197	COG0673	inositol 2-dehydrogenase activity
S100333_01198	COG0561	phosphatase activity
S100333_01199	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100333_01200	COG1609	Transcriptional regulator
S100333_01201	COG3180	Ammonia monooxygenase
S100333_01202	COG0477	Major facilitator Superfamily
S100333_01202	COG2814	Major facilitator Superfamily
S100333_01203	COG4533	DNA binding
S100333_01204	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S100333_01205	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S100333_01206	COG1074	ATP-dependent DNA helicase activity
S100333_01207	COG0420	3'-5' exonuclease activity
S100333_01208	COG0419	ATPase involved in DNA repair
S100333_01209	COG1403	HNH endonuclease
S100333_01217	COG5337	Spore coat protein CotH
S100333_01218	COG0179	Fumarylacetoacetate (FAA) hydrolase
S100333_01220	COG1404	Belongs to the peptidase S8 family
S100333_01222	COG0367	asparagine synthase
S100333_01223	COG1562	ergosterol biosynthetic process
S100333_01224	COG0534	Mate efflux family protein
S100333_01225	COG1917	Cupin 2, conserved barrel domain protein
S100333_01225	COG2207	Transcriptional regulator
S100333_01226	COG1609	Transcriptional regulator
S100333_01227	COG0673	inositol 2-dehydrogenase activity
S100333_01228	COG2318	DinB family
S100333_01229	COG1279	arginine transmembrane transporter activity
S100333_01230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_01231	COG1357	PFAM Pentapeptide repeats (8 copies)
S100333_01232	COG2267	carboxylic ester hydrolase activity
S100333_01233	COG0454	-acetyltransferase
S100333_01234	COG2153	protein acetylation
S100333_01235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S100333_01235	COG0646	methionine synthase
S100333_01236	COG1666	GTP binding
S100333_01237	COG2996	Protein conserved in bacteria
S100333_01241	COG1695	Transcriptional regulator
S100333_01244	COG3227	Zinc metalloprotease (Elastase)
S100333_01245	COG1307	EDD domain protein, DegV family
S100333_01246	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_01250	COG0561	phosphatase activity
S100333_01251	COG1073	alpha beta
S100333_01252	COG2151	metal-sulfur cluster biosynthetic enzyme
S100333_01254	COG0277	FAD linked oxidase domain protein
S100333_01255	COG2271	Major facilitator Superfamily
S100333_01256	COG2271	Major facilitator Superfamily
S100333_01257	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S100333_01260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100333_01261	COG0505	Belongs to the CarA family
S100333_01262	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100333_01263	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100333_01264	COG2801	Transposase and inactivated derivatives
S100333_01268	COG2267	carboxylic ester hydrolase activity
S100333_01270	COG1744	ABC transporter substrate-binding protein PnrA-like
S100333_01273	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100333_01274	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S100333_01275	COG5504	Zn-dependent protease
S100333_01276	COG0444	Belongs to the ABC transporter superfamily
S100333_01277	COG4608	Belongs to the ABC transporter superfamily
S100333_01279	COG0601	transmembrane transport
S100333_01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100333_01282	COG0180	Tryptophanyl-tRNA synthetase
S100333_01283	COG4166	transmembrane transport
S100333_01284	COG0601	transmembrane transport
S100333_01285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100333_01286	COG0444	Belongs to the ABC transporter superfamily
S100333_01287	COG4608	Belongs to the ABC transporter superfamily
S100333_01288	COG2814	Major facilitator Superfamily
S100333_01289	COG0456	acetyltransferase
S100333_01290	COG1393	Belongs to the ArsC family
S100333_01291	COG0861	Integral membrane protein TerC family
S100333_01292	COG4862	establishment of competence for transformation
S100333_01293	COG4469	Competence protein
S100333_01294	COG1164	Oligoendopeptidase f
S100333_01297	COG2346	COG2346, Truncated hemoglobins
S100333_01298	COG0741	lytic transglycosylase activity
S100333_01299	COG4116	CYTH
S100333_01301	COG2357	RelA SpoT domain protein
S100333_01302	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100333_01303	COG0564	pseudouridine synthase activity
S100333_01304	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S100333_01305	COG0569	domain protein
S100333_01305	COG0475	glutathione-regulated potassium exporter activity
S100333_01306	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S100333_01307	COG0352	thiamine-phosphate diphosphorylase activity
S100333_01308	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100333_01309	COG2104	thiamine diphosphate biosynthetic process
S100333_01310	COG2022	thiamine diphosphate biosynthetic process
S100333_01311	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100333_01312	COG0351	phosphomethylpyrimidine kinase
S100333_01313	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S100333_01325	COG0210	DNA helicase
S100333_01328	COG2801	Transposase and inactivated derivatives
S100333_01329	COG2153	protein acetylation
S100333_01330	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100333_01331	COG2382	esterase
S100333_01332	COG0626	cystathionine gamma-synthase activity
S100333_01333	COG0626	cystathionine gamma-synthase activity
S100333_01334	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_01335	COG5505	Protein of unknown function (DUF819)
S100333_01339	COG2856	Zn peptidase
S100333_01343	COG1396	sequence-specific DNA binding
S100333_01349	COG2801	Transposase and inactivated derivatives
S100333_01360	COG0457	Tetratricopeptide repeat
S100333_01361	COG0457	Tetratricopeptide repeat
S100333_01362	COG5444	nuclease activity
S100333_01364	COG3328	transposase activity
S100333_01378	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100333_01379	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_01381	COG3711	transcriptional antiterminator
S100333_01381	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_01382	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_01382	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100333_01382	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100333_01383	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100333_01383	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_01383	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100333_01384	COG1482	cell wall glycoprotein biosynthetic process
S100333_01386	COG3328	transposase activity
S100333_01387	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_01389	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S100333_01392	COG0109	protoheme IX farnesyltransferase activity
S100333_01394	COG0726	polysaccharide deacetylase
S100333_01397	COG5504	Zn-dependent protease
S100333_01398	COG2205	protein histidine kinase activity
S100333_01400	COG3383	formate dehydrogenase (NAD+) activity
S100333_01401	COG3383	formate dehydrogenase (NAD+) activity
S100333_01402	COG2427	Protein of unknown function (DUF1641)
S100333_01404	COG1051	belongs to the nudix hydrolase family
S100333_01406	COG2124	cytochrome p450
S100333_01407	COG1819	glycosyl
S100333_01409	COG1587	Uroporphyrinogen-III synthase
S100333_01410	COG0390	transport system, permease component
S100333_01411	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100333_01412	COG0697	spore germination
S100333_01413	COG4297	protein containing double-stranded beta helix domain
S100333_01414	COG4297	protein containing double-stranded beta helix domain
S100333_01416	COG1252	NADH dehydrogenase
S100333_01417	COG1904	glucuronate isomerase
S100333_01418	COG2211	Major facilitator Superfamily
S100333_01419	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S100333_01420	COG1063	alcohol dehydrogenase
S100333_01421	COG1312	Catalyzes the dehydration of D-mannonate
S100333_01422	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_01423	COG2271	Major facilitator Superfamily
S100333_01424	COG1609	Transcriptional regulator
S100333_01425	COG0246	Mannitol dehydrogenase
S100333_01426	COG2721	sulfolactate sulfo-lyase activity
S100333_01427	COG0730	response to heat
S100333_01430	COG2318	DinB family
S100333_01431	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100333_01432	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100333_01433	COG2801	Transposase and inactivated derivatives
S100333_01435	COG0457	Tetratricopeptide repeat
S100333_01437	COG2350	Protein conserved in bacteria
S100333_01438	COG1388	LysM domain
S100333_01438	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_01438	COG3409	Peptidoglycan-binding domain 1 protein
S100333_01440	COG4195	phage-related replication protein
S100333_01441	COG3546	catalase activity
S100333_01442	COG2856	Zn peptidase
S100333_01443	COG1396	sequence-specific DNA binding
S100333_01445	COG1522	sequence-specific DNA binding
S100333_01446	COG1484	DNA-dependent DNA replication
S100333_01451	COG1595	DNA-templated transcription, initiation
S100333_01452	COG5484	DNA packaging
S100333_01452	COG3728	DNA packaging
S100333_01453	COG1783	phage Terminase large subunit
S100333_01454	COG5518	Phage portal protein
S100333_01455	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S100333_01456	COG4653	Phage capsid family
S100333_01464	COG5412	phage tail tape measure protein
S100333_01464	COG5412	phage tail tape measure protein
S100333_01464	COG3953	SLT domain
S100333_01464	COG5412	phage tail tape measure protein
S100333_01464	COG3953	SLT domain
S100333_01464	COG3953	SLT domain
S100333_01465	COG1652	LysM domain
S100333_01466	COG4193	domain, Protein
S100333_01468	COG3628	GPW Gp25 family protein
S100333_01469	COG3299	homolog of phage Mu protein gp47
S100333_01470	COG3778	Protein conserved in bacteria
S100333_01478	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_01478	COG3409	Peptidoglycan-binding domain 1 protein
S100333_01481	COG0306	phosphate transporter
S100333_01482	COG1392	Phosphate transport regulator
S100333_01483	COG0531	amino acid
S100333_01484	COG0346	lactoylglutathione lyase activity
S100333_01485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100333_01486	COG0463	Glycosyl transferase, family 2
S100333_01488	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100333_01489	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100333_01490	COG2362	D-Aminopeptidase
S100333_01491	COG0601	transmembrane transport
S100333_01492	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100333_01493	COG0444	Belongs to the ABC transporter superfamily
S100333_01494	COG4166	transmembrane transport
S100333_01496	COG1619	proteins homologs of microcin C7 resistance protein MccF
S100333_01497	COG4948	Mandelate Racemase Muconate Lactonizing
S100333_01498	COG0791	NLP P60 protein
S100333_01499	COG4608	Belongs to the ABC transporter superfamily
S100333_01500	COG2706	6-phosphogluconolactonase activity
S100333_01501	COG1834	amidinotransferase
S100333_01502	COG1607	acyl-coa hydrolase
S100333_01503	COG1017	nitric oxide dioxygenase activity
S100333_01503	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S100333_01505	COG2323	membrane
S100333_01506	COG2318	DinB family
S100333_01507	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_01508	COG2076	Multidrug Resistance protein
S100333_01509	COG2076	Multidrug Resistance protein
S100333_01510	COG0788	formyltetrahydrofolate deformylase activity
S100333_01511	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100333_01512	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S100333_01513	COG1764	response to oxidative stress
S100333_01514	COG1846	Transcriptional regulator
S100333_01515	COG1764	response to oxidative stress
S100333_01516	COG0590	tRNA wobble adenosine to inosine editing
S100333_01517	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100333_01518	COG1404	Belongs to the peptidase S8 family
S100333_01519	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_01520	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100333_01521	COG1122	ATPase activity
S100333_01522	COG4721	ABC-type cobalt transport system, permease component
S100333_01524	COG0745	RESPONSE REGULATOR receiver
S100333_01525	COG5002	protein histidine kinase activity
S100333_01525	COG3850	Histidine kinase
S100333_01526	COG3850	Histidine kinase
S100333_01526	COG5002	protein histidine kinase activity
S100333_01527	COG3212	peptidase
S100333_01528	COG3212	peptidase
S100333_01531	COG2239	Acts as a magnesium transporter
S100333_01532	COG0789	Transcriptional regulator
S100333_01535	COG1846	Transcriptional regulator
S100333_01536	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100333_01537	COG0726	polysaccharide deacetylase
S100333_01538	COG1408	metallophosphoesterase
S100333_01540	COG0463	Glycosyl transferase, family 2
S100333_01541	COG3285	dna ligase
S100333_01541	COG1793	dna ligase
S100333_01542	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S100333_01543	COG3300	MHYT domain
S100333_01543	COG5001	Diguanylate cyclase
S100333_01544	COG0586	Pfam SNARE associated Golgi protein
S100333_01545	COG0861	Integral membrane protein TerC family
S100333_01546	COG1191	sigma factor activity
S100333_01550	COG0501	Belongs to the peptidase M48B family
S100333_01551	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100333_01554	COG3594	Acyltransferase
S100333_01555	COG5002	protein histidine kinase activity
S100333_01556	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100333_01558	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S100333_01559	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S100333_01560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100333_01561	COG0436	Aminotransferase
S100333_01562	COG1850	ribulose-bisphosphate carboxylase activity
S100333_01563	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
S100333_01564	COG0235	Class ii aldolase
S100333_01565	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S100333_01566	COG3339	Conserved Protein
S100333_01569	COG3852	Histidine kinase
S100333_01570	COG1846	Transcriptional regulator
S100333_01571	COG1360	Flagellar Motor Protein
S100333_01572	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100333_01573	COG0542	response to heat
S100333_01574	COG3949	Membrane
S100333_01575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S100333_01576	COG0720	synthase
S100333_01577	COG0602	queuosine metabolic process
S100333_01578	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S100333_01580	COG4873	Protein conserved in bacteria
S100333_01582	COG3773	Cell wall hydrolase
S100333_01583	COG2244	polysaccharide biosynthetic process
S100333_01584	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_01585	COG2217	Heavy metal translocating P-type atpase
S100333_01587	COG0006	proline dipeptidase activity
S100333_01588	COG1609	Transcriptional regulator
S100333_01590	COG3711	transcriptional antiterminator
S100333_01591	COG1263	PTS System
S100333_01591	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_01591	COG2190	(PTS) system
S100333_01592	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_01593	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S100333_01595	COG1533	DNA photolyase activity
S100333_01596	COG0456	acetyltransferase
S100333_01597	COG0840	transmembrane signaling receptor activity
S100333_01598	COG2084	Dehydrogenase
S100333_01599	COG3328	transposase activity
S100333_01600	COG2340	Cysteine-rich secretory protein family
S100333_01601	COG0768	penicillin binding
S100333_01602	COG4191	Histidine kinase
S100333_01603	COG0436	Aminotransferase
S100333_01605	COG0784	Response regulator, receiver
S100333_01605	COG0835	chemotaxis
S100333_01607	COG2814	Major facilitator Superfamily
S100333_01608	COG1376	ErfK ybiS ycfS ynhG family protein
S100333_01609	COG1408	metallophosphoesterase
S100333_01610	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_01611	COG2200	EAL domain
S100333_01612	COG4703	Protein of unknown function (DUF1797)
S100333_01613	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
S100333_01615	COG0517	IMP dehydrogenase activity
S100333_01616	COG0583	DNA-binding transcription factor activity
S100333_01617	COG0716	FMN binding
S100333_01618	COG0716	FMN binding
S100333_01620	COG0716	FMN binding
S100333_01621	COG2171	N-acyltransferase activity
S100333_01622	COG1473	amidohydrolase
S100333_01624	COG0668	transmembrane transport
S100333_01625	COG0450	alkyl hydroperoxide reductase
S100333_01626	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_01628	COG2801	Transposase and inactivated derivatives
S100333_01631	COG0746	molybdenum cofactor guanylyltransferase activity
S100333_01632	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100333_01633	COG0303	'Molybdopterin
S100333_01634	COG1763	Mo-molybdopterin cofactor biosynthetic process
S100333_01635	COG0314	molybdopterin synthase activity
S100333_01636	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S100333_01637	COG1132	(ABC) transporter
S100333_01638	COG1132	(ABC) transporter
S100333_01639	COG1132	(ABC) transporter
S100333_01641	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S100333_01642	COG1136	(ABC) transporter
S100333_01643	COG0577	efflux transmembrane transporter activity
S100333_01644	COG1349	DNA-binding transcription factor activity
S100333_01645	COG1105	Belongs to the carbohydrate kinase PfkB family
S100333_01646	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_01646	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100333_01646	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100333_01647	COG0681	Belongs to the peptidase S26 family
S100333_01649	COG0488	(ABC) transporter
S100333_01650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100333_01651	COG2309	aminopeptidase activity
S100333_01653	COG1077	Cell shape determining protein MreB Mrl
S100333_01654	COG2002	toxin-antitoxin pair type II binding
S100333_01655	COG3852	Histidine kinase
S100333_01656	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
S100333_01656	COG2105	PFAM AIG2 family protein
S100333_01657	COG0569	domain protein
S100333_01658	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100333_01659	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100333_01661	COG0561	phosphatase activity
S100333_01662	COG0242	peptide deformylase activity
S100333_01664	COG0497	DNA recombination
S100333_01665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100333_01666	COG0022	dehydrogenase e1 component
S100333_01667	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100333_01668	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100333_01669	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_01671	COG1982	Orn Lys Arg decarboxylase major
S100333_01672	COG4476	Belongs to the UPF0223 family
S100333_01673	COG4493	Belongs to the UPF0637 family
S100333_01675	COG0483	inositol monophosphate 1-phosphatase activity
S100333_01677	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S100333_01681	COG1595	DNA-templated transcription, initiation
S100333_01682	COG1595	DNA-templated transcription, initiation
S100333_01688	COG4896	Protein conserved in bacteria
S100333_01690	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S100333_01691	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100333_01692	COG2066	Belongs to the glutaminase family
S100333_01693	COG4838	Belongs to the UPF0358 family
S100333_01694	COG0772	Belongs to the SEDS family
S100333_01695	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S100333_01696	COG1612	heme a metabolic process
S100333_01697	COG0109	protoheme IX farnesyltransferase activity
S100333_01698	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S100333_01698	COG2010	Cytochrome c
S100333_01699	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S100333_01700	COG1845	cytochrome c oxidase, subunit III
S100333_01701	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100333_01702	COG3336	cytochrome c oxidase
S100333_01704	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S100333_01705	COG2340	Cysteine-rich secretory protein family
S100333_01708	COG3679	Belongs to the UPF0342 family
S100333_01709	COG4471	UPF0298 protein
S100333_01710	COG0742	ribosomal rna small subunit methyltransferase
S100333_01711	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S100333_01712	COG3314	Sporulation integral membrane protein YlbJ
S100333_01713	COG1752	Esterase of the alpha-beta hydrolase superfamily
S100333_01714	COG3480	Lon protease (S16) C-terminal proteolytic domain
S100333_01715	COG1323	Belongs to the UPF0348 family
S100333_01717	COG1399	metal-binding, possibly nucleic acid-binding protein
S100333_01718	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S100333_01720	COG0454	-acetyltransferase
S100333_01721	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100333_01722	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
S100333_01723	COG2001	Belongs to the MraZ family
S100333_01724	COG0275	rRNA processing
S100333_01725	COG4839	cell division protein FtsL
S100333_01727	COG0768	penicillin binding
S100333_01728	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S100333_01729	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100333_01730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100333_01731	COG0772	Belongs to the SEDS family
S100333_01732	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100333_01733	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S100333_01734	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S100333_01735	COG3879	Bacterial protein of unknown function (DUF881)
S100333_01736	COG3879	Bacterial protein of unknown function (DUF881)
S100333_01737	COG3856	small basic protein
S100333_01738	COG0849	cell division
S100333_01739	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S100333_01740	COG4412	M6 family metalloprotease domain protein
S100333_01740	COG1404	Belongs to the peptidase S8 family
S100333_01743	COG1191	sigma factor activity
S100333_01744	COG1191	sigma factor activity
S100333_01745	COG1119	ATPase activity
S100333_01746	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100333_01747	COG1873	PFAM PRC-barrel domain
S100333_01749	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S100333_01750	COG1799	cell septum assembly
S100333_01751	COG0762	integral membrane protein
S100333_01752	COG2302	S4 RNA-binding domain
S100333_01753	COG3599	regulation of cell shape
S100333_01754	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S100333_01755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100333_01756	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S100333_01757	COG0564	pseudouridine synthase activity
S100333_01758	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S100333_01759	COG2233	PERMEase
S100333_01760	COG0540	Belongs to the ATCase OTCase family
S100333_01761	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100333_01762	COG0505	Belongs to the CarA family
S100333_01763	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100333_01764	COG0543	2 iron, 2 sulfur cluster binding
S100333_01765	COG0167	dihydroorotate dehydrogenase activity
S100333_01766	COG0284	orotidine-5'-phosphate decarboxylase activity
S100333_01767	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S100333_01768	COG0175	sulfate reduction
S100333_01769	COG0306	phosphate transporter
S100333_01770	COG2046	Belongs to the sulfate adenylyltransferase family
S100333_01771	COG0529	Catalyzes the synthesis of activated sulfate
S100333_01772	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100333_01773	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100333_01774	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S100333_01775	COG1648	precorrin-2 dehydrogenase activity
S100333_01777	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100333_01778	COG1561	YicC-like family, N-terminal region
S100333_01779	COG2052	Domain of unknown function (DUF370)
S100333_01780	COG0194	GDP metabolic process
S100333_01781	COG1758	RNA polymerase activity
S100333_01782	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100333_01783	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100333_01784	COG0242	peptide deformylase activity
S100333_01785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S100333_01786	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S100333_01786	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100333_01787	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S100333_01788	COG0631	protein serine/threonine phosphatase activity
S100333_01789	COG2815	serine threonine protein kinase
S100333_01789	COG0515	serine threonine protein kinase
S100333_01790	COG1162	GTPase activity
S100333_01791	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S100333_01792	COG1564	THIamine pyrophosphokinase
S100333_01793	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S100333_01794	COG1302	Protein conserved in bacteria
S100333_01795	COG1461	Dihydroxyacetone kinase
S100333_01796	COG1760	l-serine dehydratase
S100333_01797	COG1760	l-serine dehydratase
S100333_01798	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S100333_01799	COG2050	protein possibly involved in aromatic compounds catabolism
S100333_01799	COG1349	DNA-binding transcription factor activity
S100333_01800	COG0416	fatty acid biosynthetic process
S100333_01801	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S100333_01802	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_01803	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100333_01804	COG0571	ribonuclease III activity
S100333_01805	COG1196	nuclear chromosome segregation
S100333_01806	COG0552	protein localization to endoplasmic reticulum
S100333_01809	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S100333_01810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S100333_01811	COG0228	four-way junction DNA binding
S100333_01812	COG1837	Belongs to the UPF0109 family
S100333_01814	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S100333_01815	COG0336	Belongs to the RNA methyltransferase TrmD family
S100333_01816	COG0335	large ribosomal subunit rRNA binding
S100333_01817	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100333_01818	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100333_01820	COG2257	FlhB HrpN YscU SpaS Family
S100333_01821	COG0045	succinate-CoA ligase (ADP-forming) activity
S100333_01822	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S100333_01823	COG0758	DNA mediated transformation
S100333_01824	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100333_01825	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S100333_01826	COG4974	Belongs to the 'phage' integrase family
S100333_01827	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S100333_01828	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S100333_01829	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100333_01830	COG1815	bacterial-type flagellum-dependent cell motility
S100333_01831	COG1558	bacterial-type flagellum-dependent cell motility
S100333_01832	COG1677	Flagellar hook-basal body complex protein FliE
S100333_01833	COG1766	The M ring may be actively involved in energy transduction
S100333_01834	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100333_01835	COG1317	bacterial-type flagellum organization
S100333_01836	COG1157	protein secretion by the type III secretion system
S100333_01837	COG2882	bacterial-type flagellum organization
S100333_01838	COG3334	PFAM MgtE intracellular
S100333_01839	COG3144	bacterial-type flagellum assembly
S100333_01840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S100333_01841	COG4786	Flagellar basal body rod
S100333_01842	COG1580	Controls the rotational direction of flagella during chemotaxis
S100333_01843	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100333_01844	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100333_01844	COG1776	CheC inhibitor of MCP methylation
S100333_01845	COG2201	protein-glutamate methylesterase activity
S100333_01846	COG3190	flagellar
S100333_01847	COG1338	Plays a role in the flagellum-specific transport system
S100333_01848	COG1987	bacterial-type flagellum assembly
S100333_01849	COG1684	flagellar biosynthetic protein fliR
S100333_01850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100333_01851	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100333_01852	COG1419	protein localization to endoplasmic reticulum
S100333_01853	COG0455	bacterial-type flagellum organization
S100333_01854	COG2201	protein-glutamate methylesterase activity
S100333_01855	COG2198	Histidine kinase
S100333_01855	COG0643	Histidine kinase
S100333_01856	COG0835	chemotaxis
S100333_01857	COG1776	CheC inhibitor of MCP methylation
S100333_01858	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S100333_01859	COG1191	sigma factor activity
S100333_01861	COG0052	Belongs to the universal ribosomal protein uS2 family
S100333_01862	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S100333_01863	COG0528	UMP kinase activity
S100333_01864	COG0233	cytoplasmic translational termination
S100333_01865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S100333_01866	COG4589	Belongs to the CDS family
S100333_01867	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S100333_01868	COG0750	zinc metalloprotease
S100333_01869	COG0442	prolyl-tRNA aminoacylation
S100333_01870	COG2176	DNA-directed DNA polymerase activity
S100333_01871	COG0779	Required for maturation of 30S ribosomal subunits
S100333_01872	COG0195	Participates in both transcription termination and antitermination
S100333_01873	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S100333_01874	COG1358	cellular component organization or biogenesis
S100333_01875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S100333_01876	COG1550	Protein conserved in bacteria
S100333_01877	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S100333_01878	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S100333_01879	COG0196	riboflavin kinase activity
S100333_01880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S100333_01881	COG1185	polyribonucleotide nucleotidyltransferase activity
S100333_01882	COG0726	polysaccharide deacetylase
S100333_01883	COG0612	Peptidase, M16
S100333_01884	COG1873	PFAM PRC-barrel domain
S100333_01885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100333_01886	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100333_01887	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S100333_01888	COG0527	aspartate kinase activity
S100333_01889	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100333_01890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100333_01891	COG0740	serine-type endopeptidase activity
S100333_01892	COG0740	serine-type endopeptidase activity
S100333_01894	COG1674	ftsk spoiiie
S100333_01894	COG4980	gas vesicle protein
S100333_01895	COG2188	Transcriptional regulator
S100333_01896	COG2814	Major facilitator Superfamily
S100333_01897	COG2814	Major facilitator Superfamily
S100333_01898	COG0612	Peptidase, M16
S100333_01899	COG0612	Peptidase, M16
S100333_01900	COG0300	oxidoreductase activity
S100333_01903	COG1426	Protein conserved in bacteria
S100333_01904	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S100333_01905	COG1546	Belongs to the CinA family
S100333_01905	COG1058	Belongs to the CinA family
S100333_01906	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S100333_01907	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100333_01908	COG1418	mRNA catabolic process
S100333_01909	COG1692	metallophosphoesterase
S100333_01910	COG2359	stage V sporulation protein S
S100333_01911	COG1063	alcohol dehydrogenase
S100333_01912	COG0156	8-amino-7-oxononanoate synthase activity
S100333_01913	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100333_01914	COG4550	Control of competence regulator ComK, YlbF/YmcA
S100333_01916	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S100333_01917	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S100333_01920	COG3226	Transcriptional regulator
S100333_01922	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_01923	COG1404	Belongs to the peptidase S8 family
S100333_01925	COG4195	phage-related replication protein
S100333_01926	COG1764	response to oxidative stress
S100333_01927	COG2076	Multidrug Resistance protein
S100333_01928	COG2076	Multidrug Resistance protein
S100333_01931	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S100333_01932	COG1923	regulation of RNA biosynthetic process
S100333_01935	COG1780	Probably involved in ribonucleotide reductase function
S100333_01936	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100333_01937	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100333_01938	COG4112	unkown
S100333_01939	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_01940	COG0464	growth
S100333_01941	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S100333_01942	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S100333_01943	COG0789	Transcriptional regulator
S100333_01944	COG0174	glutamine synthetase
S100333_01945	COG4974	Belongs to the 'phage' integrase family
S100333_01949	COG3645	SOS response
S100333_01949	COG3646	Phage regulatory protein
S100333_01985	COG5280	Phage tail tape measure protein TP901
S100333_01985	COG3953	SLT domain
S100333_01987	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100333_01994	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_01994	COG3409	Peptidoglycan-binding domain 1 protein
S100333_01994	COG1388	LysM domain
S100333_01996	COG5444	nuclease activity
S100333_02003	COG4282	regulation of fungal-type cell wall biogenesis
S100333_02006	COG3328	transposase activity
S100333_02008	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_02012	COG3655	Transcriptional regulator
S100333_02016	COG0135	phosphoribosylanthranilate isomerase activity
S100333_02017	COG2211	Major facilitator Superfamily
S100333_02018	COG3507	Belongs to the glycosyl hydrolase 43 family
S100333_02019	COG1940	carbohydrate kinase activity
S100333_02020	COG2115	Belongs to the xylose isomerase family
S100333_02021	COG1070	Carbohydrate kinase
S100333_02022	COG3328	transposase activity
S100333_02023	COG1525	nuclease
S100333_02024	COG2814	Major facilitator Superfamily
S100333_02025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100333_02028	COG0756	dUTP diphosphatase activity
S100333_02037	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100333_02039	COG3832	glyoxalase III activity
S100333_02042	COG0697	spore germination
S100333_02043	COG0697	spore germination
S100333_02050	COG4195	phage-related replication protein
S100333_02052	COG0346	lactoylglutathione lyase activity
S100333_02053	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S100333_02054	COG1388	LysM domain
S100333_02055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S100333_02056	COG4224	UPF0291 protein
S100333_02057	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S100333_02059	COG3763	UPF0154 protein
S100333_02061	COG0785	Cytochrome C biogenesis protein
S100333_02062	COG2201	protein-glutamate methylesterase activity
S100333_02063	COG4846	Membrane protein involved in cytochrome C biogenesis
S100333_02065	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_02068	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S100333_02069	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_02073	COG0824	Thioesterase
S100333_02075	COG4841	protein insertion into membrane
S100333_02076	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S100333_02077	COG1832	CoA-binding protein
S100333_02078	COG0187	DNA topoisomerase II activity
S100333_02079	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100333_02082	COG1115	amino acid carrier protein
S100333_02083	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
S100333_02085	COG5520	Belongs to the glycosyl hydrolase 30 family
S100333_02086	COG3507	Belongs to the glycosyl hydrolase 43 family
S100333_02087	COG3507	Belongs to the glycosyl hydrolase 43 family
S100333_02088	COG2246	polysaccharide biosynthetic process
S100333_02089	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100333_02090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100333_02091	COG0586	Pfam SNARE associated Golgi protein
S100333_02092	COG2404	hydrolase activity, acting on ester bonds
S100333_02093	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100333_02094	COG1024	Enoyl-CoA hydratase
S100333_02095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100333_02096	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100333_02097	COG0511	ligase activity, forming carbon-carbon bonds
S100333_02098	COG0439	Biotin carboxylase
S100333_02099	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_02100	COG1960	acyl-CoA dehydrogenase activity
S100333_02101	COG1649	PFAM Uncharacterised BCR, COG1649
S100333_02103	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
S100333_02103	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_02104	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
S100333_02104	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_02105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
S100333_02105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_02106	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_02107	COG2027	D-alanyl-D-alanine carboxypeptidase
S100333_02108	COG2017	converts alpha-aldose to the beta-anomer
S100333_02109	COG0534	Mate efflux family protein
S100333_02112	COG0582	viral genome integration into host DNA
S100333_02113	COG0166	Belongs to the GPI family
S100333_02114	COG0405	Gamma-glutamyltransferase
S100333_02115	COG0583	DNA-binding transcription factor activity
S100333_02116	COG0604	alcohol dehydrogenase
S100333_02117	COG0493	'glutamate synthase
S100333_02118	COG0069	glutamate synthase activity
S100333_02118	COG0070	glutamate synthase
S100333_02118	COG0067	glutamate synthase
S100333_02119	COG0583	DNA-binding transcription factor activity
S100333_02120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100333_02121	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100333_02123	COG0300	oxidoreductase activity
S100333_02124	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S100333_02126	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_02129	COG1131	(ABC) transporter
S100333_02131	COG2814	Major facilitator Superfamily
S100333_02132	COG1070	Carbohydrate kinase
S100333_02133	COG2323	membrane
S100333_02134	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100333_02137	COG2323	membrane
S100333_02140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100333_02145	COG3546	catalase activity
S100333_02149	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_02153	COG0840	transmembrane signaling receptor activity
S100333_02153	COG5278	phosphoserine phosphatase activity
S100333_02154	COG2368	4-hydroxyphenylacetate
S100333_02155	COG4305	rare lipoprotein A
S100333_02156	COG4305	rare lipoprotein A
S100333_02157	COG3619	membrane
S100333_02158	COG3866	Pectate lyase
S100333_02159	COG3866	Pectate lyase
S100333_02160	COG2135	peptidase activity
S100333_02163	COG2140	Oxalate decarboxylase
S100333_02164	COG2140	Oxalate decarboxylase
S100333_02168	COG2720	vancomycin resistance protein
S100333_02170	COG3655	Transcriptional regulator
S100333_02171	COG3739	integral membrane protein
S100333_02172	COG0583	DNA-binding transcription factor activity
S100333_02173	COG0697	spore germination
S100333_02175	COG0693	protein deglycase activity
S100333_02176	COG2367	Beta-lactamase
S100333_02179	COG0574	Belongs to the PEP-utilizing enzyme family
S100333_02179	COG3848	Pyruvate phosphate dikinase
S100333_02180	COG0726	polysaccharide deacetylase
S100333_02181	COG2314	TM2 domain
S100333_02182	COG1396	sequence-specific DNA binding
S100333_02183	COG3328	transposase activity
S100333_02196	COG3655	Transcriptional regulator
S100333_02204	COG0457	Tetratricopeptide repeat
S100333_02206	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_02208	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100333_02209	COG2226	methyltransferase
S100333_02210	COG2211	Major facilitator Superfamily
S100333_02211	COG3328	transposase activity
S100333_02212	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100333_02213	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100333_02214	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100333_02217	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_02221	COG5444	nuclease activity
S100333_02222	COG5444	nuclease activity
S100333_02223	COG5444	nuclease activity
S100333_02224	COG4282	regulation of fungal-type cell wall biogenesis
S100333_02225	COG1231	oxidoreductase activity
S100333_02226	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_02227	COG0662	Cupin 2, conserved barrel domain protein
S100333_02227	COG2207	Transcriptional regulator
S100333_02228	COG0456	acetyltransferase
S100333_02229	COG0456	acetyltransferase
S100333_02230	COG1309	transcriptional regulator
S100333_02231	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_02232	COG3708	Transcriptional regulator
S100333_02233	COG2378	regulation of single-species biofilm formation
S100333_02235	COG0640	Transcriptional regulator
S100333_02236	COG0741	lytic transglycosylase activity
S100333_02237	COG2322	membrane
S100333_02241	COG1619	proteins homologs of microcin C7 resistance protein MccF
S100333_02242	COG3239	Fatty acid desaturase
S100333_02243	COG4585	Histidine kinase
S100333_02244	COG2197	response regulator
S100333_02246	COG3584	3D domain protein
S100333_02246	COG1388	LysM domain
S100333_02247	COG0514	ATP-dependent DNA helicase (RecQ)
S100333_02249	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100333_02250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100333_02251	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100333_02254	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_02259	COG1012	belongs to the aldehyde dehydrogenase family
S100333_02260	COG1657	PFAM Prenyltransferase squalene oxidase
S100333_02261	COG1657	PFAM Prenyltransferase squalene oxidase
S100333_02262	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100333_02263	COG0733	neurotransmitter:sodium symporter activity
S100333_02264	COG0385	Bile acid
S100333_02265	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100333_02266	COG0567	Dehydrogenase, E1 component
S100333_02267	COG4548	von Willebrand factor, type A
S100333_02268	COG0714	Associated with various cellular activities
S100333_02269	COG2032	superoxide dismutase activity
S100333_02270	COG1388	LysM domain
S100333_02270	COG0791	NLP P60 protein
S100333_02271	COG1819	glycosyl
S100333_02272	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S100333_02274	COG0534	Mate efflux family protein
S100333_02275	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_02276	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100333_02277	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100333_02279	COG2962	Rard protein
S100333_02282	COG2610	gluconate transmembrane transporter activity
S100333_02283	COG2610	gluconate transmembrane transporter activity
S100333_02284	COG1942	4-Oxalocrotonate Tautomerase
S100333_02285	COG1733	regulation of RNA biosynthetic process
S100333_02286	COG0778	Nitroreductase
S100333_02287	COG0400	carboxylic ester hydrolase activity
S100333_02288	COG0346	lactoylglutathione lyase activity
S100333_02290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_02291	COG3409	Peptidoglycan-binding domain 1 protein
S100333_02291	COG0793	Belongs to the peptidase S41A family
S100333_02292	COG2226	methyltransferase
S100333_02294	COG1876	peptidase activity
S100333_02295	COG0813	purine-nucleoside phosphorylase activity
S100333_02298	COG0671	phosphoesterase, PA-phosphatase related
S100333_02302	COG4479	Belongs to the UPF0346 family
S100333_02304	COG1509	lysine 2,3-aminomutase activity
S100333_02305	COG0456	acetyltransferase
S100333_02306	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100333_02307	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S100333_02308	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S100333_02309	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100333_02311	COG0456	acetyltransferase
S100333_02312	COG0463	Glycosyl transferase, family 2
S100333_02315	COG4641	Protein conserved in bacteria
S100333_02316	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
S100333_02317	COG1086	Polysaccharide biosynthesis protein
S100333_02318	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100333_02319	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100333_02320	COG1846	Transcriptional regulator
S100333_02321	COG0534	Mate efflux family protein
S100333_02323	COG4698	Protein conserved in bacteria
S100333_02324	COG2755	lipolytic protein G-D-S-L family
S100333_02325	COG1999	signal sequence binding
S100333_02327	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S100333_02328	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100333_02329	COG1272	protein, Hemolysin III
S100333_02330	COG0204	Acyl-transferase
S100333_02331	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100333_02332	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100333_02334	COG2521	methyltransferase
S100333_02334	COG2136	Putative SAM-dependent methyltransferase
S100333_02336	COG0129	dihydroxy-acid dehydratase activity
S100333_02337	COG1413	lyase activity
S100333_02338	COG1418	mRNA catabolic process
S100333_02339	COG0386	Belongs to the glutathione peroxidase family
S100333_02340	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S100333_02341	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100333_02342	COG1278	Cold shock
S100333_02346	COG0328	RNA-DNA hybrid ribonuclease activity
S100333_02347	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
S100333_02348	COG0328	RNA-DNA hybrid ribonuclease activity
S100333_02350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100333_02353	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100333_02354	COG1755	Isoprenylcysteine carboxyl methyltransferase
S100333_02355	COG3424	synthase
S100333_02356	COG3424	synthase
S100333_02357	COG2233	PERMEase
S100333_02358	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100333_02359	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S100333_02361	COG0800	Aldolase
S100333_02362	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_02363	COG1609	Transcriptional regulator
S100333_02364	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S100333_02365	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_02366	COG1199	ATP-dependent helicase activity
S100333_02368	COG0116	Belongs to the methyltransferase superfamily
S100333_02370	COG4474	Belongs to the UPF0398 family
S100333_02371	COG3359	exonuclease
S100333_02372	COG1205	dead DEAH box helicase
S100333_02372	COG1111	helicase
S100333_02373	COG2190	(PTS) system
S100333_02374	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_02381	COG3331	DNA recombination
S100333_02382	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100333_02382	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100333_02384	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S100333_02385	COG3935	DnaD domain protein
S100333_02386	COG0017	Asparaginyl-tRNA synthetase
S100333_02387	COG0436	Aminotransferase
S100333_02388	COG5353	protein conserved in bacteria
S100333_02390	COG1199	ATP-dependent helicase activity
S100333_02390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S100333_02391	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S100333_02392	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S100333_02393	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S100333_02394	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
S100333_02394	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
S100333_02395	COG0617	tRNA 3'-terminal CCA addition
S100333_02396	COG0438	transferase activity, transferring glycosyl groups
S100333_02397	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100333_02398	COG1803	Methylglyoxal synthase
S100333_02399	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S100333_02400	COG1694	Mazg nucleotide pyrophosphohydrolase
S100333_02401	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_02403	COG4347	Protein of unknown function (DUF1405)
S100333_02404	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100333_02404	COG2010	Cytochrome c
S100333_02405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100333_02406	COG0723	plastoquinol--plastocyanin reductase activity
S100333_02408	COG5582	Belongs to the UPF0302 family
S100333_02409	COG0457	Tetratricopeptide repeat
S100333_02410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S100333_02411	COG0287	Prephenate dehydrogenase
S100333_02414	COG0133	tryptophan synthase activity
S100333_02415	COG0135	phosphoribosylanthranilate isomerase activity
S100333_02417	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100333_02418	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100333_02419	COG4401	Chorismate mutase type I
S100333_02420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S100333_02421	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S100333_02422	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S100333_02423	COG0105	UTP biosynthetic process
S100333_02424	COG0142	geranyltranstransferase activity
S100333_02425	COG2226	methyltransferase
S100333_02426	COG0142	geranyltranstransferase activity
S100333_02428	COG0302	gtp cyclohydrolase
S100333_02429	COG0776	regulation of translation
S100333_02430	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100333_02433	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S100333_02434	COG1160	GTP binding
S100333_02439	COG2801	Transposase and inactivated derivatives
S100333_02441	COG1304	FMN binding
S100333_02442	COG0539	negative regulation of cytoplasmic translation
S100333_02443	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S100333_02445	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
S100333_02446	COG2959	enzyme of heme biosynthesis
S100333_02447	COG3773	Cell wall hydrolase
S100333_02447	COG3409	Peptidoglycan-binding domain 1 protein
S100333_02448	COG2339	peptidase activity
S100333_02449	COG0492	ferredoxin-NADP+ reductase activity
S100333_02450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100333_02451	COG4862	establishment of competence for transformation
S100333_02452	COG1408	metallophosphoesterase
S100333_02453	COG1408	metallophosphoesterase
S100333_02455	COG1388	LysM domain
S100333_02456	COG1266	CAAX protease self-immunity
S100333_02457	COG0514	ATP-dependent DNA helicase (RecQ)
S100333_02458	COG4955	Helix-turn-helix domain
S100333_02459	COG1141	Ferredoxin
S100333_02460	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S100333_02461	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S100333_02462	COG0710	3-dehydroquinate dehydratase activity
S100333_02464	COG1595	DNA-templated transcription, initiation
S100333_02465	COG5002	protein histidine kinase activity
S100333_02466	COG0745	RESPONSE REGULATOR receiver
S100333_02467	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100333_02468	COG1333	cytochrome c biogenesis protein
S100333_02469	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_02470	COG1187	pseudouridine synthase activity
S100333_02471	COG0700	Nucleoside recognition
S100333_02472	COG2715	membrane protein required for spore maturation
S100333_02473	COG1686	Belongs to the peptidase S11 family
S100333_02475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S100333_02476	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S100333_02477	COG1547	Domain of unknown function (DUF309)
S100333_02478	COG0456	acetyltransferase
S100333_02479	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S100333_02480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100333_02480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100333_02481	COG0307	riboflavin synthase, alpha
S100333_02482	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100333_02482	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100333_02484	COG0681	Belongs to the peptidase S26 family
S100333_02485	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
S100333_02487	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100333_02488	COG2433	Pfam Transposase IS66
S100333_02494	COG3328	transposase activity
S100333_02495	COG3012	SEC-C Motif Domain Protein
S100333_02499	COG0457	Tetratricopeptide repeat
S100333_02500	COG5444	nuclease activity
S100333_02502	COG3328	transposase activity
S100333_02512	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100333_02513	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100333_02514	COG4086	secreted protein
S100333_02515	COG0019	diaminopimelate decarboxylase activity
S100333_02516	COG0697	spore germination
S100333_02519	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100333_02523	COG1191	sigma factor activity
S100333_02524	COG2172	sigma factor antagonist activity
S100333_02525	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_02526	COG1686	Belongs to the peptidase S11 family
S100333_02527	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S100333_02528	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S100333_02529	COG4974	Belongs to the 'phage' integrase family
S100333_02531	COG0735	belongs to the Fur family
S100333_02532	COG1300	Membrane
S100333_02534	COG0281	malic enzyme
S100333_02535	COG1757	Na H antiporter
S100333_02536	COG1027	Aspartate ammonia-lyase
S100333_02537	COG0252	asparaginase activity
S100333_02538	COG1396	sequence-specific DNA binding
S100333_02539	COG1379	DNA repair
S100333_02540	COG0494	nUDIX hydrolase
S100333_02542	COG0667	Aldo Keto reductase
S100333_02544	COG1073	alpha beta
S100333_02546	COG4918	Iron-sulphur cluster biosynthesis
S100333_02547	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S100333_02547	COG0456	acetyltransferase
S100333_02548	COG2329	Antibiotic biosynthesis monooxygenase
S100333_02549	COG0456	acetyltransferase
S100333_02551	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100333_02553	COG2211	Major facilitator Superfamily
S100333_02555	COG0346	lactoylglutathione lyase activity
S100333_02556	COG1072	(Pantothenic acid kinase))
S100333_02557	COG3048	D-serine ammonia-lyase activity
S100333_02558	COG0300	oxidoreductase activity
S100333_02559	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_02560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100333_02561	COG4187	Peptidase family M20/M25/M40
S100333_02562	COG1902	pentaerythritol trinitrate reductase activity
S100333_02563	COG0596	Alpha beta hydrolase
S100333_02565	COG1234	tRNA 3'-trailer cleavage
S100333_02566	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S100333_02567	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100333_02568	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100333_02570	COG0706	membrane insertase activity
S100333_02571	COG3361	conserved protein (COG2071)
S100333_02572	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100333_02573	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100333_02574	COG0346	lactoylglutathione lyase activity
S100333_02576	COG1376	ErfK ybiS ycfS ynhG family protein
S100333_02577	COG4129	membrane
S100333_02578	COG1126	abc transporter atp-binding protein
S100333_02579	COG0765	amino acid transport
S100333_02580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_02582	COG1597	lipid kinase activity
S100333_02583	COG2814	Major facilitator Superfamily
S100333_02584	COG0789	Transcriptional regulator
S100333_02584	COG4978	Transcriptional regulator
S100333_02585	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100333_02586	COG0022	dehydrogenase e1 component
S100333_02587	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100333_02588	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100333_02589	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100333_02590	COG3426	butyrate kinase activity
S100333_02591	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100333_02592	COG0280	phosphate acetyltransferase
S100333_02593	COG3290	protein histidine kinase activity
S100333_02593	COG3829	transcription factor binding
S100333_02595	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S100333_02596	COG2079	MmgE PrpD family protein
S100333_02597	COG0372	Belongs to the citrate synthase family
S100333_02598	COG1960	acyl-CoA dehydrogenase activity
S100333_02599	COG1960	acyl-CoA dehydrogenase activity
S100333_02600	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100333_02601	COG0183	Belongs to the thiolase family
S100333_02602	COG0584	glycerophosphoryl diester phosphodiesterase
S100333_02603	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_02605	COG1902	pentaerythritol trinitrate reductase activity
S100333_02607	COG0745	RESPONSE REGULATOR receiver
S100333_02608	COG0750	zinc metalloprotease
S100333_02609	COG0497	DNA recombination
S100333_02610	COG1438	arginine binding
S100333_02611	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S100333_02612	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S100333_02613	COG0142	geranyltranstransferase activity
S100333_02614	COG1722	exodeoxyribonuclease VII activity
S100333_02615	COG1570	exodeoxyribonuclease VII activity
S100333_02616	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S100333_02617	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100333_02618	COG1302	Protein conserved in bacteria
S100333_02619	COG0439	Biotin carboxylase
S100333_02620	COG0511	ligase activity, forming carbon-carbon bonds
S100333_02629	COG3854	ATPases associated with a variety of cellular activities
S100333_02631	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S100333_02632	COG0006	proline dipeptidase activity
S100333_02633	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S100333_02635	COG3872	metal-dependent enzyme
S100333_02637	COG1752	Esterase of the alpha-beta hydrolase superfamily
S100333_02638	COG1321	iron dependent repressor
S100333_02639	COG0095	Lipoate-protein ligase
S100333_02640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100333_02641	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100333_02642	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100333_02643	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S100333_02644	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100333_02647	COG1396	sequence-specific DNA binding
S100333_02649	COG0681	Belongs to the peptidase S26 family
S100333_02654	COG4940	Competence protein ComGF
S100333_02656	COG4970	Tfp pilus assembly protein FimT
S100333_02657	COG4537	Required for transformation and DNA binding
S100333_02658	COG1459	type II secretion system
S100333_02659	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S100333_02660	COG0517	IMP dehydrogenase activity
S100333_02661	COG0598	Magnesium transport protein CorA
S100333_02662	COG1253	flavin adenine dinucleotide binding
S100333_02663	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_02665	COG1393	Belongs to the ArsC family
S100333_02667	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_02669	COG0011	TIGRFAM Protein of
S100333_02671	COG2866	Carboxypeptidase
S100333_02672	COG1368	sulfuric ester hydrolase activity
S100333_02673	COG1940	carbohydrate kinase activity
S100333_02674	COG4483	Protein conserved in bacteria
S100333_02675	COG0457	Tetratricopeptide repeat
S100333_02675	COG0705	Rhomboid family
S100333_02677	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S100333_02678	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100333_02679	COG0438	transferase activity, transferring glycosyl groups
S100333_02682	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100333_02683	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100333_02684	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100333_02685	COG0581	inorganic phosphate transmembrane transporter activity
S100333_02686	COG0573	inorganic phosphate transmembrane transporter activity
S100333_02687	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S100333_02689	COG0477	Major facilitator Superfamily
S100333_02690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100333_02691	COG2839	Protein conserved in bacteria
S100333_02692	COG5521	maltodextrose utilization protein MalA
S100333_02693	COG1388	LysM domain
S100333_02694	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S100333_02695	COG4709	membrane
S100333_02696	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
S100333_02697	COG0735	belongs to the Fur family
S100333_02698	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_02700	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S100333_02701	COG0513	Belongs to the DEAD box helicase family
S100333_02703	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S100333_02704	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S100333_02705	COG2384	SAM-dependent methyltransferase
S100333_02706	COG2010	Cytochrome c
S100333_02707	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S100333_02708	COG0358	DNA primase activity
S100333_02709	COG1671	Belongs to the UPF0178 family
S100333_02710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S100333_02711	COG0517	IMP dehydrogenase activity
S100333_02712	COG0751	glycine-tRNA ligase activity
S100333_02713	COG0752	glycyl-tRNA synthetase alpha subunit
S100333_02714	COG1381	Involved in DNA repair and RecF pathway recombination
S100333_02716	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S100333_02717	COG0295	cytidine deaminase activity
S100333_02718	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S100333_02719	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S100333_02720	COG1480	7TM receptor with intracellular HD hydrolase
S100333_02722	COG1702	phosphate starvation-inducible protein PhoH
S100333_02723	COG0561	phosphatase activity
S100333_02726	COG4864	UPF0365 protein
S100333_02727	COG1030	water channel activity
S100333_02728	COG1610	YqeY-like protein
S100333_02729	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S100333_02730	COG1283	sodium-dependent phosphate transmembrane transporter activity
S100333_02731	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100333_02732	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S100333_02733	COG2264	protein methyltransferase activity
S100333_02734	COG0484	heat shock protein binding
S100333_02735	COG0443	Heat shock 70 kDa protein
S100333_02736	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S100333_02737	COG1420	regulation of RNA biosynthetic process
S100333_02738	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100333_02739	COG0481	GTPase activity
S100333_02741	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_02742	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S100333_02743	COG0268	Binds directly to 16S ribosomal RNA
S100333_02744	COG1466	dna polymerase III delta subunit
S100333_02746	COG0658	competence protein
S100333_02746	COG2333	competence protein COMEC
S100333_02747	COG2131	deaminase
S100333_02748	COG1555	photosystem II stabilization
S100333_02748	COG1596	polysaccharide export
S100333_02749	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100333_02750	COG2226	methyltransferase
S100333_02751	COG0799	negative regulation of ribosome biogenesis
S100333_02752	COG1713	HD superfamily hydrolase involved in NAD metabolism
S100333_02753	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S100333_02754	COG1534	Rna-binding protein
S100333_02755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S100333_02756	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100333_02757	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S100333_02759	COG2755	lipolytic protein G-D-S-L family
S100333_02760	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_02760	COG3409	Peptidoglycan-binding domain 1 protein
S100333_02761	COG0398	Pfam SNARE associated Golgi protein
S100333_02762	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S100333_02764	COG3209	COG3209 Rhs family protein
S100333_02766	COG0114	fumarate hydratase activity
S100333_02767	COG0583	DNA-binding transcription factor activity
S100333_02770	COG0457	Tetratricopeptide repeat
S100333_02771	COG5444	nuclease activity
S100333_02772	COG5444	nuclease activity
S100333_02794	COG4978	Transcriptional regulator
S100333_02794	COG0789	Transcriptional regulator
S100333_02795	COG2814	Major facilitator Superfamily
S100333_02796	COG0456	acetyltransferase
S100333_02797	COG3328	transposase activity
S100333_02798	COG1253	flavin adenine dinucleotide binding
S100333_02800	COG0697	spore germination
S100333_02801	COG0697	spore germination
S100333_02802	COG0583	DNA-binding transcription factor activity
S100333_02803	COG2072	flavoprotein involved in K transport
S100333_02804	COG1230	cation diffusion facilitator family transporter
S100333_02806	COG1114	Component of the transport system for branched-chain amino acids
S100333_02807	COG1687	branched-chain amino acid
S100333_02808	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
S100333_02809	COG1522	sequence-specific DNA binding
S100333_02810	COG2732	(Barnase) inhibitor
S100333_02811	COG2124	cytochrome p450
S100333_02813	COG1335	isochorismatase
S100333_02816	COG2318	DinB family
S100333_02818	COG2070	2-Nitropropane dioxygenase
S100333_02819	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100333_02822	COG3443	Belongs to the bacterial solute-binding protein 9 family
S100333_02823	COG1595	DNA-templated transcription, initiation
S100333_02824	COG0667	Aldo Keto reductase
S100333_02825	COG3409	Peptidoglycan-binding domain 1 protein
S100333_02826	COG5566	PFAM Mor transcription activator
S100333_02827	COG0596	Alpha beta hydrolase
S100333_02828	COG4991	sh3 domain protein
S100333_02829	COG4991	sh3 domain protein
S100333_02830	COG0346	lactoylglutathione lyase activity
S100333_02832	COG5577	PFAM Coat F domain
S100333_02833	COG1063	alcohol dehydrogenase
S100333_02835	COG5577	PFAM Coat F domain
S100333_02836	COG0789	Transcriptional regulator
S100333_02838	COG1064	alcohol dehydrogenase
S100333_02839	COG0693	protein deglycase activity
S100333_02840	COG1621	beta-fructofuranosidase activity
S100333_02841	COG3716	PTS system mannose fructose sorbose family IID component
S100333_02842	COG3715	PTS system
S100333_02843	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_02844	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_02845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100333_02845	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S100333_02846	COG1113	amino acid transport
S100333_02847	COG1280	lysine exporter protein (LysE YggA)
S100333_02848	COG1378	Sugar-specific transcriptional regulator TrmB
S100333_02849	COG1595	DNA-templated transcription, initiation
S100333_02850	COG1595	DNA-templated transcription, initiation
S100333_02852	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S100333_02852	COG2755	lipolytic protein G-D-S-L family
S100333_02853	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S100333_02853	COG2755	lipolytic protein G-D-S-L family
S100333_02855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100333_02855	COG2124	cytochrome p450
S100333_02856	COG1309	transcriptional regulator
S100333_02857	COG2226	methyltransferase
S100333_02860	COG2116	formate transmembrane transporter activity
S100333_02861	COG5609	conserved protein (DUF2294)
S100333_02862	COG3383	formate dehydrogenase (NAD+) activity
S100333_02863	COG2427	Protein of unknown function (DUF1641)
S100333_02865	COG0626	cystathionine gamma-synthase activity
S100333_02866	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100333_02867	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S100333_02868	COG2226	methyltransferase
S100333_02871	COG0768	penicillin binding
S100333_02872	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S100333_02873	COG0572	uridine kinase
S100333_02877	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100333_02878	COG3906	Belongs to the UPF0473 family
S100333_02879	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S100333_02880	COG4472	Bacterial protein of unknown function (DUF965)
S100333_02881	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S100333_02882	COG0628	permease
S100333_02883	COG1126	abc transporter atp-binding protein
S100333_02884	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_02885	COG0765	amino acid transport
S100333_02886	COG0765	amino acid transport
S100333_02889	COG3881	PFAM PRC-barrel domain
S100333_02890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S100333_02891	COG0457	Tetratricopeptide repeat
S100333_02892	COG0482	sulfurtransferase activity
S100333_02893	COG1104	cysteine desulfurase activity
S100333_02894	COG1959	2 iron, 2 sulfur cluster binding
S100333_02895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S100333_02896	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S100333_02897	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S100333_02898	COG0124	histidyl-tRNA synthetase
S100333_02900	COG4991	sh3 domain protein
S100333_02900	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_02900	COG3103	Sh3 type 3 domain protein
S100333_02901	COG1490	D-aminoacyl-tRNA deacylase activity
S100333_02902	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S100333_02903	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100333_02904	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S100333_02904	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S100333_02905	COG5416	Lipopolysaccharide assembly protein A domain
S100333_02906	COG0490	domain, Protein
S100333_02907	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100333_02907	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100333_02909	COG2244	polysaccharide biosynthetic process
S100333_02910	COG2323	membrane
S100333_02912	COG1862	Preprotein translocase
S100333_02913	COG0343	queuine tRNA-ribosyltransferase activity
S100333_02914	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S100333_02916	COG2255	four-way junction helicase activity
S100333_02917	COG0632	four-way junction helicase activity
S100333_02919	COG2814	Major facilitator Superfamily
S100333_02920	COG0673	inositol 2-dehydrogenase activity
S100333_02921	COG2112	serine threonine protein kinase
S100333_02922	COG2112	serine threonine protein kinase
S100333_02925	COG1115	amino acid carrier protein
S100333_02926	COG0217	transcriptional regulatory protein
S100333_02928	COG1388	LysM domain
S100333_02929	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S100333_02930	COG0157	Belongs to the NadC ModD family
S100333_02931	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S100333_02932	COG1104	cysteine desulfurase activity
S100333_02933	COG1827	regulation of RNA biosynthetic process
S100333_02934	COG0077	Prephenate dehydratase
S100333_02935	COG4492	Belongs to the UPF0735 family
S100333_02936	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S100333_02937	COG3290	protein histidine kinase activity
S100333_02938	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S100333_02939	COG2868	ribosomal protein
S100333_02940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S100333_02941	COG1994	Peptidase M50
S100333_02942	COG0739	heme binding
S100333_02943	COG2894	cell division
S100333_02944	COG0850	regulation of cytokinetic process
S100333_02945	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S100333_02946	COG1792	Involved in formation and maintenance of cell shape
S100333_02947	COG1077	Cell shape determining protein MreB Mrl
S100333_02948	COG2003	Belongs to the UPF0758 family
S100333_02949	COG0424	maF-like protein
S100333_02951	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S100333_02952	COG0285	dihydrofolate synthase activity
S100333_02953	COG0525	valine-tRNA ligase activity
S100333_02955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_02956	COG1388	LysM domain
S100333_02957	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100333_02958	COG0113	porphobilinogen synthase activity
S100333_02959	COG1587	Uroporphyrinogen-III synthase
S100333_02960	COG0181	hydroxymethylbilane synthase activity
S100333_02961	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100333_02962	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S100333_02964	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S100333_02965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S100333_02966	COG1067	ATP-dependent peptidase activity
S100333_02966	COG0470	DNA polymerase III
S100333_02967	COG1067	ATP-dependent peptidase activity
S100333_02967	COG0470	DNA polymerase III
S100333_02968	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S100333_02969	COG0544	peptidyl-prolyl cis-trans isomerase activity
S100333_02970	COG1477	protein flavinylation
S100333_02970	COG0457	Tetratricopeptide repeat
S100333_02971	COG0066	3-isopropylmalate dehydratase activity
S100333_02972	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S100333_02973	COG0473	3-isopropylmalate dehydrogenase activity
S100333_02974	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100333_02975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S100333_02976	COG0440	acetolactate synthase activity
S100333_02977	COG0028	Belongs to the TPP enzyme family
S100333_02979	COG0454	-acetyltransferase
S100333_02980	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
S100333_02982	COG2801	Transposase and inactivated derivatives
S100333_02987	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
S100333_02992	COG0622	Phosphoesterase
S100333_02993	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S100333_02994	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S100333_02995	COG5401	PFAM Sporulation and spore germination
S100333_02996	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100333_02997	COG1846	Transcriptional regulator
S100333_02998	COG2197	response regulator
S100333_02999	COG0824	Thioesterase
S100333_03000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S100333_03001	COG1053	succinate dehydrogenase
S100333_03002	COG2009	succinate dehydrogenase
S100333_03003	COG1719	4-vinyl reductase, 4VR
S100333_03004	COG0527	aspartate kinase activity
S100333_03005	COG0322	excinuclease ABC activity
S100333_03006	COG3118	belongs to the thioredoxin family
S100333_03007	COG3534	alpha-L-arabinofuranosidase
S100333_03009	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S100333_03010	COG2086	electron transfer activity
S100333_03011	COG1024	Enoyl-CoA hydratase
S100333_03012	COG1309	transcriptional regulator
S100333_03013	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_03014	COG3766	membrane
S100333_03015	COG1193	negative regulation of DNA recombination
S100333_03016	COG1796	DNA polymerase
S100333_03016	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100333_03017	COG1286	toxin biosynthetic process
S100333_03018	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S100333_03019	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100333_03020	COG0072	phenylalanine-tRNA ligase activity
S100333_03020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_03021	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S100333_03022	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100333_03024	COG3835	regulator
S100333_03025	COG0277	FAD linked oxidase domain protein
S100333_03026	COG0247	lactate metabolic process
S100333_03027	COG0346	lactoylglutathione lyase activity
S100333_03028	COG1966	Carbon starvation protein
S100333_03029	COG3534	alpha-L-arabinofuranosidase
S100333_03030	COG0395	ABC-type sugar transport system, permease component
S100333_03031	COG1175	transmembrane transport
S100333_03032	COG1653	transport
S100333_03033	COG0371	Dehydrogenase
S100333_03034	COG0647	UMP catabolic process
S100333_03035	COG0235	Class ii aldolase
S100333_03036	COG1069	ribulokinase activity
S100333_03037	COG2160	L-arabinose isomerase activity
S100333_03038	COG3507	Belongs to the glycosyl hydrolase 43 family
S100333_03039	COG1363	Peptidase, m42
S100333_03041	COG3326	Membrane
S100333_03042	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S100333_03043	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S100333_03044	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S100333_03046	COG1346	cytolysis
S100333_03047	COG1380	Effector of murein hydrolase LrgA
S100333_03048	COG3279	Response regulator of the LytR AlgR family
S100333_03049	COG3275	phosphorelay sensor kinase activity
S100333_03051	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100333_03054	COG0398	Pfam SNARE associated Golgi protein
S100333_03055	COG1484	DNA-dependent DNA replication
S100333_03056	COG3611	Membrane attachment protein
S100333_03057	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S100333_03058	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S100333_03059	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100333_03060	COG1733	regulation of RNA biosynthetic process
S100333_03061	COG2814	Major facilitator Superfamily
S100333_03062	COG0656	L-ascorbic acid biosynthetic process
S100333_03063	COG0237	dephospho-CoA kinase activity
S100333_03064	COG1971	Probably functions as a manganese efflux pump
S100333_03065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S100333_03066	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100333_03066	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100333_03067	COG5002	protein histidine kinase activity
S100333_03068	COG5002	protein histidine kinase activity
S100333_03069	COG0745	RESPONSE REGULATOR receiver
S100333_03070	COG0039	L-malate dehydrogenase activity
S100333_03071	COG0538	isocitrate dehydrogenase activity
S100333_03072	COG0372	Belongs to the citrate synthase family
S100333_03073	COG2707	UPF0756 membrane protein
S100333_03074	COG0628	permease
S100333_03075	COG3030	protein affecting phage T7 exclusion by the F plasmid
S100333_03076	COG0469	pyruvate kinase activity
S100333_03077	COG0205	6-phosphofructokinase activity
S100333_03078	COG0825	malonyl-CoA metabolic process
S100333_03079	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S100333_03080	COG0281	malic enzyme
S100333_03081	COG0587	DNA-directed DNA polymerase activity
S100333_03085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S100333_03087	COG4109	DRTGG domain
S100333_03088	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S100333_03089	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_03091	COG0165	Argininosuccinate lyase
S100333_03092	COG0137	argininosuccinate synthase activity
S100333_03093	COG0521	Mo-molybdopterin cofactor biosynthetic process
S100333_03094	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100333_03095	COG0827	DNA restriction-modification system
S100333_03096	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S100333_03097	COG3874	Sporulation protein YtfJ
S100333_03099	COG1714	RDD family
S100333_03100	COG0616	signal peptide processing
S100333_03101	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100333_03102	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S100333_03103	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100333_03105	COG0301	tRNA thio-modification
S100333_03106	COG1104	cysteine desulfurase activity
S100333_03107	COG1114	Component of the transport system for branched-chain amino acids
S100333_03108	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S100333_03109	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100333_03110	COG1309	transcriptional regulator
S100333_03111	COG1956	GAF domain-containing protein
S100333_03112	COG2801	Transposase and inactivated derivatives
S100333_03114	COG2203	Gaf domain
S100333_03114	COG2199	diguanylate cyclase activity
S100333_03115	COG2203	Gaf domain
S100333_03115	COG2199	diguanylate cyclase activity
S100333_03116	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S100333_03118	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100333_03119	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100333_03120	COG0454	-acetyltransferase
S100333_03121	COG0517	IMP dehydrogenase activity
S100333_03122	COG0123	including yeast histone deacetylase and acetoin utilization protein
S100333_03123	COG1360	Flagellar Motor Protein
S100333_03124	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100333_03125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100333_03126	COG1609	Transcriptional regulator
S100333_03127	COG1605	Chorismate mutase
S100333_03127	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S100333_03128	COG3118	belongs to the thioredoxin family
S100333_03129	COG4980	gas vesicle protein
S100333_03130	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S100333_03131	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S100333_03132	COG1674	ftsk spoiiie
S100333_03133	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_03134	COG4848	Belongs to the UPF0354 family
S100333_03135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_03137	COG1363	Peptidase, m42
S100333_03138	COG5584	Small secreted protein
S100333_03139	COG0281	malic enzyme
S100333_03140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_03141	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S100333_03143	COG0510	thiamine kinase activity
S100333_03144	COG1523	belongs to the glycosyl hydrolase 13 family
S100333_03145	COG1597	lipid kinase activity
S100333_03146	COG1597	lipid kinase activity
S100333_03148	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100333_03149	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100333_03150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100333_03151	COG2252	PERMEase
S100333_03152	COG4473	ABC transporter
S100333_03153	COG1131	(ABC) transporter
S100333_03154	COG1349	DNA-binding transcription factor activity
S100333_03155	COG1187	pseudouridine synthase activity
S100333_03156	COG2244	polysaccharide biosynthetic process
S100333_03157	COG2244	polysaccharide biosynthetic process
S100333_03158	COG2081	HI0933 family
S100333_03159	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S100333_03161	COG5578	integral membrane protein
S100333_03162	COG0673	inositol 2-dehydrogenase activity
S100333_03163	COG0673	inositol 2-dehydrogenase activity
S100333_03164	COG1653	transport
S100333_03165	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S100333_03166	COG4209	transmembrane transport
S100333_03167	COG2207	Transcriptional regulator
S100333_03168	COG1653	transport
S100333_03169	COG0395	ABC-type sugar transport system, permease component
S100333_03170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100333_03171	COG2124	cytochrome p450
S100333_03172	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S100333_03174	COG0156	8-amino-7-oxononanoate synthase activity
S100333_03175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100333_03176	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
S100333_03177	COG1073	alpha beta
S100333_03182	COG1486	melibiose metabolic process
S100333_03183	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100333_03184	COG0495	leucyl-tRNA aminoacylation
S100333_03186	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_03186	COG2202	Pas domain
S100333_03187	COG2814	Major facilitator Superfamily
S100333_03188	COG2433	Pfam Transposase IS66
S100333_03189	COG0577	efflux transmembrane transporter activity
S100333_03190	COG1136	(ABC) transporter
S100333_03191	COG2205	protein histidine kinase activity
S100333_03192	COG0745	RESPONSE REGULATOR receiver
S100333_03193	COG0577	efflux transmembrane transporter activity
S100333_03194	COG1136	(ABC) transporter
S100333_03197	COG1131	(ABC) transporter
S100333_03198	COG1725	Transcriptional regulator
S100333_03201	COG1242	4 iron, 4 sulfur cluster binding
S100333_03202	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S100333_03204	COG2267	carboxylic ester hydrolase activity
S100333_03205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S100333_03206	COG1113	amino acid transport
S100333_03207	COG0367	asparagine synthase
S100333_03208	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S100333_03209	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S100333_03211	COG1506	peptidase
S100333_03212	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100333_03213	COG1116	anion transmembrane transporter activity
S100333_03214	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100333_03215	COG0494	nUDIX hydrolase
S100333_03216	COG4824	toxin secretion phage lysis holin
S100333_03217	COG0783	Belongs to the Dps family
S100333_03220	COG1854	S-ribosylhomocysteine lyase activity
S100333_03221	COG0288	reversible hydration of carbon dioxide
S100333_03222	COG0254	rRNA binding
S100333_03223	COG1271	oxidase subunit
S100333_03224	COG1294	oxidase, subunit
S100333_03226	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100333_03227	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100333_03227	COG1321	iron dependent repressor
S100333_03228	COG1121	(ABC) transporter
S100333_03229	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100333_03230	COG4948	Mandelate Racemase Muconate Lactonizing
S100333_03231	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_03232	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S100333_03233	COG0596	Alpha beta hydrolase
S100333_03234	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
S100333_03235	COG1169	isochorismate synthase
S100333_03236	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100333_03237	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100333_03238	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100333_03239	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100333_03240	COG0438	transferase activity, transferring glycosyl groups
S100333_03242	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_03243	COG0438	transferase activity, transferring glycosyl groups
S100333_03244	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_03245	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S100333_03246	COG0058	SHG alpha-glucan phosphorylase activity
S100333_03247	COG0297	glycogen (starch) synthase activity
S100333_03248	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100333_03249	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100333_03250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S100333_03275	COG3859	Proton-coupled thiamine transporter YuaJ
S100333_03276	COG1247	-acetyltransferase
S100333_03277	COG2268	Band 7 protein
S100333_03278	COG1585	Membrane protein implicated in regulation of membrane protease activity
S100333_03280	COG2318	DinB family
S100333_03282	COG1454	alcohol dehydrogenase
S100333_03284	COG1510	regulation of RNA biosynthetic process
S100333_03287	COG2801	Transposase and inactivated derivatives
S100333_03288	COG0569	domain protein
S100333_03289	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100333_03290	COG4682	membrane
S100333_03291	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100333_03292	COG0477	Major facilitator Superfamily
S100333_03293	COG5553	Cysteine dioxygenase type I
S100333_03295	COG1968	undecaprenyl-diphosphatase activity
S100333_03296	COG0628	permease
S100333_03297	COG0673	inositol 2-dehydrogenase activity
S100333_03298	COG4806	L-rhamnose isomerase
S100333_03299	COG3254	rhamnose metabolic process
S100333_03300	COG1070	Carbohydrate kinase
S100333_03301	COG1349	DNA-binding transcription factor activity
S100333_03302	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_03302	COG3347	Dehydrogenase
S100333_03303	COG0840	transmembrane signaling receptor activity
S100333_03304	COG0840	transmembrane signaling receptor activity
S100333_03305	COG0840	transmembrane signaling receptor activity
S100333_03306	COG0840	transmembrane signaling receptor activity
S100333_03307	COG0840	transmembrane signaling receptor activity
S100333_03308	COG0840	transmembrane signaling receptor activity
S100333_03311	COG0366	Alpha amylase catalytic
S100333_03312	COG1253	flavin adenine dinucleotide binding
S100333_03313	COG2738	Putative neutral zinc metallopeptidase
S100333_03316	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S100333_03319	COG0166	Belongs to the GPI family
S100333_03320	COG1979	alcohol dehydrogenase
S100333_03321	COG1979	alcohol dehydrogenase
S100333_03322	COG2155	Conserved Protein
S100333_03323	COG1098	S1 RNA binding domain
S100333_03324	COG0436	Aminotransferase
S100333_03325	COG1522	sequence-specific DNA binding
S100333_03326	COG2267	carboxylic ester hydrolase activity
S100333_03328	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100333_03329	COG2205	protein histidine kinase activity
S100333_03331	COG5018	Exonuclease
S100333_03333	COG2814	Major facilitator Superfamily
S100333_03334	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100333_03335	COG3011	Protein conserved in bacteria
S100333_03337	COG3290	protein histidine kinase activity
S100333_03338	COG4565	transcriptional regulatory protein
S100333_03343	COG3493	citrate carrier protein
S100333_03345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100333_03345	COG2111	Na H antiporter
S100333_03346	COG2111	Na H antiporter
S100333_03347	COG1006	Multisubunit Na H antiporter MnhC subunit
S100333_03348	COG0651	ATP synthesis coupled electron transport
S100333_03349	COG1863	multisubunit Na H antiporter MnhE subunit
S100333_03350	COG2212	antiporter activity
S100333_03351	COG1320	monovalent cation:proton antiporter activity
S100333_03352	COG2050	protein possibly involved in aromatic compounds catabolism
S100333_03353	COG2197	response regulator
S100333_03354	COG4585	Histidine kinase
S100333_03356	COG0142	geranyltranstransferase activity
S100333_03360	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S100333_03361	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S100333_03362	COG1335	isochorismatase
S100333_03363	COG5506	Protein of unknown function (DUF1694)
S100333_03366	COG0628	permease
S100333_03369	COG1418	mRNA catabolic process
S100333_03370	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_03372	COG1511	domain protein
S100333_03373	COG0433	COG0433 Predicted ATPase
S100333_03373	COG1674	ftsk spoiiie
S100333_03374	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100333_03375	COG5417	Belongs to the EsaB family
S100333_03376	COG4842	Belongs to the WXG100 family
S100333_03377	COG2508	Transcriptional regulator
S100333_03377	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100333_03378	COG0686	Belongs to the AlaDH PNT family
S100333_03379	COG5634	Uncharacterized conserved protein (DUF2278)
S100333_03380	COG3251	PFAM MbtH domain protein
S100333_03381	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_03382	COG3433	isochorismatase activity
S100333_03382	COG1535	isochorismatase
S100333_03383	COG1021	2,3-dihydroxybenzoate-AMP ligase
S100333_03384	COG1169	isochorismate synthase
S100333_03385	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_03386	COG2819	hydrolase of the alpha beta superfamily
S100333_03387	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100333_03388	COG1268	BioY protein
S100333_03389	COG2056	Na+-H+ antiporter family
S100333_03390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S100333_03391	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S100333_03392	COG3584	3D domain protein
S100333_03394	COG1252	NADH dehydrogenase
S100333_03395	COG0492	ferredoxin-NADP+ reductase activity
S100333_03397	COG0516	GMP reductase activity
S100333_03398	COG2808	Putative FMN-binding domain
S100333_03399	COG0316	Belongs to the HesB IscA family
S100333_03400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S100333_03401	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100333_03402	COG4844	belongs to the
S100333_03403	COG1252	NADH dehydrogenase
S100333_03404	COG4837	Protein of unknown function (DUF1462)
S100333_03405	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S100333_03406	COG4946	Tricorn protease homolog
S100333_03406	COG1506	peptidase
S100333_03406	COG0823	Involved in the tonB-independent uptake of proteins
S100333_03407	COG0083	homoserine kinase activity
S100333_03408	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S100333_03409	COG0460	homoserine dehydrogenase
S100333_03410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_03411	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_03412	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100333_03413	COG0647	UMP catabolic process
S100333_03414	COG2445	Protein of unknown function DUF86
S100333_03415	COG4470	Protein conserved in bacteria
S100333_03417	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S100333_03418	COG0739	heme binding
S100333_03420	COG3377	Domain of unknown function (DUF1805)
S100333_03421	COG0737	Belongs to the 5'-nucleotidase family
S100333_03422	COG0730	response to heat
S100333_03423	COG1801	Protein of unknown function DUF72
S100333_03425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100333_03426	COG2508	Transcriptional regulator
S100333_03427	COG2233	PERMEase
S100333_03428	COG2233	PERMEase
S100333_03429	COG3648	Uricase
S100333_03429	COG3195	allantoin biosynthetic process
S100333_03430	COG2351	hydroxyisourate hydrolase activity
S100333_03433	COG2080	2 iron, 2 sulfur cluster binding
S100333_03434	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S100333_03435	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S100333_03436	COG2068	MobA-Related Protein
S100333_03437	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S100333_03438	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S100333_03439	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100333_03440	COG2356	endonuclease I
S100333_03441	COG3842	ATPase activity
S100333_03442	COG2188	Transcriptional regulator
S100333_03443	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_03444	COG0395	ABC-type sugar transport system, permease component
S100333_03445	COG0395	ABC-type sugar transport system, permease component
S100333_03446	COG1175	transmembrane transport
S100333_03447	COG1653	transport
S100333_03448	COG1653	transport
S100333_03449	COG2222	sugar isomerase
S100333_03450	COG0322	excinuclease ABC activity
S100333_03451	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100333_03454	COG2801	Transposase and inactivated derivatives
S100333_03456	COG0346	lactoylglutathione lyase activity
S100333_03457	COG0640	Transcriptional regulator
S100333_03458	COG0719	Fe-S assembly protein
S100333_03459	COG0822	iron-sulfur transferase activity
S100333_03460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100333_03461	COG0719	Fe-S assembly protein
S100333_03462	COG0396	ATPase activity
S100333_03463	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S100333_03464	COG1464	Belongs to the NlpA lipoprotein family
S100333_03465	COG2011	ABC-type metal ion transport system permease component
S100333_03466	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100333_03468	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_03469	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100333_03471	COG0509	glycine decarboxylation via glycine cleavage system
S100333_03472	COG1393	Belongs to the ArsC family
S100333_03473	COG1960	acyl-CoA dehydrogenase activity
S100333_03474	COG0183	Belongs to the thiolase family
S100333_03475	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100333_03475	COG1024	Enoyl-CoA hydratase
S100333_03479	COG5577	PFAM Coat F domain
S100333_03480	COG1846	Transcriptional regulator
S100333_03481	COG0477	Major facilitator Superfamily
S100333_03482	COG1942	4-Oxalocrotonate Tautomerase
S100333_03483	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_03484	COG0583	DNA-binding transcription factor activity
S100333_03486	COG1120	ATPase activity
S100333_03490	COG3328	transposase activity
S100333_03493	COG3328	transposase activity
S100333_03496	COG1131	(ABC) transporter
S100333_03504	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_03505	COG0783	Belongs to the Dps family
S100333_03506	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100333_03507	COG0745	RESPONSE REGULATOR receiver
S100333_03508	COG2770	Histidine kinase
S100333_03508	COG2205	protein histidine kinase activity
S100333_03509	COG1309	transcriptional regulator
S100333_03510	COG0114	fumarate hydratase activity
S100333_03512	COG0697	spore germination
S100333_03513	COG0814	amino acid
S100333_03515	COG2197	response regulator
S100333_03516	COG4585	Histidine kinase
S100333_03517	COG4758	membrane
S100333_03518	COG3595	metallopeptidase activity
S100333_03519	COG1842	Phage shock protein A
S100333_03520	COG4758	membrane
S100333_03521	COG2814	Major facilitator Superfamily
S100333_03522	COG2096	Adenosyltransferase
S100333_03523	COG1120	ATPase activity
S100333_03524	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_03525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_03526	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_03529	COG3386	PFAM SMP-30 Gluconolaconase
S100333_03530	COG2205	protein histidine kinase activity
S100333_03531	COG0745	RESPONSE REGULATOR receiver
S100333_03532	COG1191	sigma factor activity
S100333_03534	COG2140	Oxalate decarboxylase
S100333_03536	COG0577	efflux transmembrane transporter activity
S100333_03537	COG1136	(ABC) transporter
S100333_03538	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S100333_03539	COG1120	ATPase activity
S100333_03540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_03541	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_03542	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_03544	COG0531	amino acid
S100333_03546	COG1988	membrane-bound metal-dependent
S100333_03547	COG1368	sulfuric ester hydrolase activity
S100333_03548	COG1910	domain protein
S100333_03549	COG0725	ABC transporter, periplasmic molybdate-binding protein
S100333_03550	COG4149	molybdate abc transporter
S100333_03551	COG0656	L-ascorbic acid biosynthetic process
S100333_03553	COG0025	NhaP-type Na H and K H
S100333_03554	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100333_03555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100333_03556	COG3973	AAA domain
S100333_03557	COG2860	membrane
S100333_03558	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S100333_03559	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S100333_03560	COG2217	Heavy metal translocating P-type atpase
S100333_03561	COG2217	Heavy metal translocating P-type atpase
S100333_03562	COG2608	mercury ion transmembrane transporter activity
S100333_03563	COG1937	Protein conserved in bacteria
S100333_03564	COG0673	inositol 2-dehydrogenase activity
S100333_03565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100333_03566	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100333_03567	COG1289	transmembrane transporter activity
S100333_03568	COG1289	transmembrane transporter activity
S100333_03570	COG2076	Multidrug Resistance protein
S100333_03571	COG1309	transcriptional regulator
S100333_03572	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_03575	COG5444	nuclease activity
S100333_03578	COG3409	Peptidoglycan-binding domain 1 protein
S100333_03578	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_03579	COG4824	toxin secretion phage lysis holin
S100333_03584	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100333_03584	COG3942	CHAP domain
S100333_03607	COG0582	viral genome integration into host DNA
S100333_03634	COG0582	viral genome integration into host DNA
S100333_03635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S100333_03636	COG0557	exoribonuclease II activity
S100333_03637	COG1647	Serine aminopeptidase, S33
S100333_03638	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100333_03639	COG0596	Alpha beta hydrolase
S100333_03640	COG1476	TRANSCRIPTIONal
S100333_03641	COG1396	sequence-specific DNA binding
S100333_03642	COG1396	sequence-specific DNA binding
S100333_03643	COG1733	regulation of RNA biosynthetic process
S100333_03644	COG0840	transmembrane signaling receptor activity
S100333_03645	COG0840	transmembrane signaling receptor activity
S100333_03646	COG1174	glycine betaine transport
S100333_03647	COG1732	Glycine betaine
S100333_03648	COG1174	glycine betaine transport
S100333_03649	COG1125	glycine betaine transport
S100333_03649	COG0517	IMP dehydrogenase activity
S100333_03650	COG1125	glycine betaine transport
S100333_03650	COG0517	IMP dehydrogenase activity
S100333_03651	COG1510	regulation of RNA biosynthetic process
S100333_03652	COG1174	glycine betaine transport
S100333_03653	COG1732	Glycine betaine
S100333_03654	COG1174	glycine betaine transport
S100333_03655	COG1125	glycine betaine transport
S100333_03655	COG0517	IMP dehydrogenase activity
S100333_03656	COG1510	regulation of RNA biosynthetic process
S100333_03657	COG2095	MarC family integral membrane protein
S100333_03659	COG3064	Membrane
S100333_03660	COG4640	response to antibiotic
S100333_03661	COG0456	acetyltransferase
S100333_03662	COG0148	phosphopyruvate hydratase activity
S100333_03663	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S100333_03664	COG0149	triose-phosphate isomerase activity
S100333_03665	COG0126	phosphoglycerate kinase activity
S100333_03666	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100333_03667	COG2390	Transcriptional regulator
S100333_03668	COG2814	Major facilitator Superfamily
S100333_03669	COG1609	Transcriptional regulator
S100333_03670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100333_03671	COG0583	DNA-binding transcription factor activity
S100333_03672	COG0697	spore germination
S100333_03673	COG1113	amino acid transport
S100333_03674	COG3858	chitin binding
S100333_03675	COG1556	Lactate utilization protein
S100333_03676	COG1139	Iron-sulfur cluster binding protein
S100333_03677	COG0247	lactate metabolic process
S100333_03678	COG2197	response regulator
S100333_03679	COG4585	Histidine kinase
S100333_03680	COG0842	Transport permease protein
S100333_03681	COG1131	(ABC) transporter
S100333_03685	COG0596	Alpha beta hydrolase
S100333_03686	COG2208	phosphoserine phosphatase activity
S100333_03687	COG3867	Arabinogalactan endo-beta-1,4-galactanase
S100333_03688	COG1874	Beta-galactosidase
S100333_03689	COG3833	ABC-type maltose transport systems, permease component
S100333_03690	COG1175	transmembrane transport
S100333_03691	COG2182	Extracellular solute-binding protein
S100333_03692	COG1609	Transcriptional regulator
S100333_03693	COG2186	Transcriptional regulator
S100333_03694	COG1620	l-lactate permease
S100333_03695	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S100333_03697	COG5039	Polysaccharide pyruvyl transferase
S100333_03698	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100333_03699	COG0110	maltose O-acetyltransferase activity
S100333_03700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100333_03701	COG2244	polysaccharide biosynthetic process
S100333_03702	COG1216	Glycosyl transferase, family 2
S100333_03703	COG5039	Polysaccharide pyruvyl transferase
S100333_03704	COG1216	Glycosyl transferase, family 2
S100333_03706	COG0438	transferase activity, transferring glycosyl groups
S100333_03707	COG1215	transferase activity, transferring glycosyl groups
S100333_03708	COG0438	transferase activity, transferring glycosyl groups
S100333_03709	COG1086	Polysaccharide biosynthesis protein
S100333_03710	COG0489	protein tyrosine kinase activity
S100333_03711	COG3944	biosynthesis protein
S100333_03712	COG1396	sequence-specific DNA binding
S100333_03713	COG2272	Belongs to the type-B carboxylesterase lipase family
S100333_03715	COG3479	Phenolic acid decarboxylase
S100333_03718	COG1794	racemase activity, acting on amino acids and derivatives
S100333_03719	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100333_03720	COG1621	beta-fructofuranosidase activity
S100333_03721	COG1621	beta-fructofuranosidase activity
S100333_03722	COG0531	amino acid
S100333_03723	COG1309	transcriptional regulator
S100333_03724	COG2076	Multidrug Resistance protein
S100333_03725	COG2076	Multidrug Resistance protein
S100333_03728	COG0740	serine-type endopeptidase activity
S100333_03729	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100333_03730	COG0366	Alpha amylase catalytic
S100333_03731	COG1554	hydrolase, family 65, central catalytic
S100333_03732	COG3833	ABC-type maltose transport systems, permease component
S100333_03733	COG1175	transmembrane transport
S100333_03734	COG2182	Extracellular solute-binding protein
S100333_03735	COG0366	Alpha amylase catalytic
S100333_03736	COG1609	Transcriptional regulator
S100333_03737	COG1611	Belongs to the LOG family
S100333_03738	COG1694	Mazg nucleotide pyrophosphohydrolase
S100333_03739	COG0659	secondary active sulfate transmembrane transporter activity
S100333_03740	COG0288	reversible hydration of carbon dioxide
S100333_03741	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100333_03742	COG0577	efflux transmembrane transporter activity
S100333_03743	COG1136	(ABC) transporter
S100333_03744	COG5002	protein histidine kinase activity
S100333_03745	COG0745	RESPONSE REGULATOR receiver
S100333_03747	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S100333_03748	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_03749	COG1481	regulation of sporulation
S100333_03750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S100333_03751	COG1660	Displays ATPase and GTPase activities
S100333_03752	COG1051	belongs to the nudix hydrolase family
S100333_03753	COG1051	belongs to the nudix hydrolase family
S100333_03754	COG0492	ferredoxin-NADP+ reductase activity
S100333_03755	COG3883	PFAM NLP P60 protein
S100333_03755	COG0791	NLP P60 protein
S100333_03756	COG0457	Tetratricopeptide repeat
S100333_03757	COG1132	(ABC) transporter
S100333_03761	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S100333_03761	COG0140	phosphoribosyl-ATP diphosphatase activity
S100333_03762	COG0107	imidazoleglycerol-phosphate synthase activity
S100333_03763	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S100333_03764	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S100333_03765	COG0131	Imidazoleglycerol-phosphate dehydratase
S100333_03766	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S100333_03767	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S100333_03768	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S100333_03769	COG4990	cell redox homeostasis
S100333_03770	COG5297	Belongs to the glycosyl hydrolase family 6
S100333_03772	COG2801	Transposase and inactivated derivatives
S100333_03773	COG0110	maltose O-acetyltransferase activity
S100333_03774	COG0546	phosphoglycolate phosphatase activity
S100333_03775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S100333_03776	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S100333_03777	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S100333_03778	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S100333_03779	COG0363	glucosamine-6-phosphate deaminase activity
S100333_03781	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S100333_03782	COG1950	PFAM Membrane protein of
S100333_03783	COG1983	PspC domain protein
S100333_03784	COG3595	metallopeptidase activity
S100333_03787	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100333_03788	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100333_03789	COG0556	nucleotide-excision repair
S100333_03790	COG4897	Protein conserved in bacteria
S100333_03791	COG3848	Pyruvate phosphate dikinase
S100333_03791	COG0574	Belongs to the PEP-utilizing enzyme family
S100333_03793	COG1309	transcriptional regulator
S100333_03794	COG2814	Major facilitator Superfamily
S100333_03795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100333_03797	COG0793	Belongs to the peptidase S41A family
S100333_03797	COG3409	Peptidoglycan-binding domain 1 protein
S100333_03798	COG2177	Part of the ABC transporter FtsEX involved in
S100333_03799	COG2884	Cell division ATP-binding protein ftsE
S100333_03800	COG2010	Cytochrome c
S100333_03801	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_03802	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S100333_03803	COG0653	protein targeting
S100333_03805	COG2801	Transposase and inactivated derivatives
S100333_03806	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S100333_03809	COG1516	flagellar protein fliS
S100333_03810	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S100333_03811	COG1334	flagellar protein FlaG
S100333_03812	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100333_03813	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S100333_03814	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
S100333_03816	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100333_03817	COG4786	Flagellar basal body rod
S100333_03817	COG1256	bacterial-type flagellum assembly
S100333_03818	COG3418	PFAM FlgN family protein
S100333_03819	COG2747	anti-sigma28 factor FlgM
S100333_03821	COG1040	competence protein
S100333_03823	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S100333_03824	COG1307	EDD domain protein, DegV family
S100333_03825	COG2197	response regulator
S100333_03826	COG4585	Histidine kinase
S100333_03827	COG1739	Uncharacterized protein family UPF0029
S100333_03828	COG1316	TRANSCRIPTIONal
S100333_03835	COG1131	(ABC) transporter
S100333_03837	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100333_03838	COG0438	transferase activity, transferring glycosyl groups
S100333_03839	COG1215	transferase activity, transferring glycosyl groups
S100333_03840	COG3206	protein involved in exopolysaccharide biosynthesis
S100333_03841	COG3307	-O-antigen
S100333_03843	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100333_03844	COG0297	glycogen (starch) synthase activity
S100333_03844	COG0438	transferase activity, transferring glycosyl groups
S100333_03845	COG2244	polysaccharide biosynthetic process
S100333_03847	COG2247	cell wall binding repeat
S100333_03847	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_03848	COG2247	cell wall binding repeat
S100333_03848	COG2385	sporulation resulting in formation of a cellular spore
S100333_03850	COG1316	TRANSCRIPTIONal
S100333_03851	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S100333_03852	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100333_03854	COG1134	teichoic acid transport
S100333_03855	COG1682	transport, permease protein
S100333_03857	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100333_03857	COG0463	Glycosyl transferase, family 2
S100333_03858	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100333_03859	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S100333_03860	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S100333_03861	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100333_03862	COG4193	domain, Protein
S100333_03863	COG1482	cell wall glycoprotein biosynthetic process
S100333_03864	COG0697	spore germination
S100333_03865	COG0814	amino acid
S100333_03866	COG0814	amino acid
S100333_03868	COG2814	Major facilitator Superfamily
S100333_03869	COG1316	TRANSCRIPTIONal
S100333_03870	COG0561	phosphatase activity
S100333_03871	COG0791	NLP P60 protein
S100333_03873	COG2843	Capsule synthesis protein
S100333_03875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100333_03876	COG1609	Transcriptional regulator
S100333_03877	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_03878	COG1869	D-ribose catabolic process
S100333_03879	COG1129	ABC transporter
S100333_03880	COG1172	Belongs to the binding-protein-dependent transport system permease family
S100333_03881	COG1879	ABC-type sugar transport system periplasmic component
S100333_03882	COG3103	Sh3 type 3 domain protein
S100333_03884	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100333_03885	COG3527	Alpha-acetolactate decarboxylase
S100333_03886	COG0028	Belongs to the TPP enzyme family
S100333_03887	COG0583	DNA-binding transcription factor activity
S100333_03888	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S100333_03891	COG5337	Spore coat protein CotH
S100333_03893	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100333_03895	COG0405	Gamma-glutamyltransferase
S100333_03896	COG1522	sequence-specific DNA binding
S100333_03897	COG2059	Chromate
S100333_03898	COG2059	Chromate
S100333_03900	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100333_03901	COG0583	DNA-binding transcription factor activity
S100333_03905	COG5444	nuclease activity
S100333_03908	COG5444	nuclease activity
S100333_03911	COG3878	Protein conserved in bacteria
S100333_03912	COG3878	Protein conserved in bacteria
S100333_03913	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100333_03914	COG4464	protein tyrosine phosphatase activity
S100333_03915	COG0489	protein tyrosine kinase activity
S100333_03916	COG3944	biosynthesis protein
S100333_03918	COG4715	Zinc finger, swim domain protein
S100333_03919	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100333_03920	COG0561	phosphatase activity
S100333_03921	COG1349	DNA-binding transcription factor activity
S100333_03922	COG0629	single-stranded DNA binding
S100333_03925	COG3764	Sortase (surface protein transpeptidase)
S100333_03926	COG2972	Histidine kinase
S100333_03926	COG0745	RESPONSE REGULATOR receiver
S100333_03927	COG1970	mechanosensitive ion channel activity
S100333_03928	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100333_03929	COG0457	Tetratricopeptide repeat
S100333_03930	COG4786	Flagellar basal body rod
S100333_03931	COG4786	Flagellar basal body rod
S100333_03932	COG1077	Cell shape determining protein MreB Mrl
S100333_03933	COG1609	Transcriptional regulator
S100333_03934	COG1846	Transcriptional regulator
S100333_03935	COG2814	Major facilitator Superfamily
S100333_03936	COG3420	alginic acid biosynthetic process
S100333_03937	COG1953	Uracil, thiamine, allantoin
S100333_03938	COG0477	Major facilitator Superfamily
S100333_03939	COG1335	isochorismatase
S100333_03941	COG0004	ammonium transporteR
S100333_03942	COG0347	Belongs to the P(II) protein family
S100333_03943	COG0671	phosphoesterase, PA-phosphatase related
S100333_03945	COG0739	heme binding
S100333_03946	COG1247	-acetyltransferase
S100333_03948	COG2089	acid synthase
S100333_03950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100333_03951	COG0789	Transcriptional regulator
S100333_03953	COG2910	NAD(P)H-binding
S100333_03954	COG2910	NAD(P)H-binding
S100333_03955	COG1959	2 iron, 2 sulfur cluster binding
S100333_03956	COG0804	urea catabolic process
S100333_03957	COG0832	Belongs to the urease beta subunit family
S100333_03958	COG0831	urea catabolic process
S100333_03960	COG3237	CsbD-like
S100333_03961	COG1994	Peptidase M50
S100333_03962	COG0457	Tetratricopeptide repeat
S100333_03963	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S100333_03964	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S100333_03966	COG2304	oxidoreductase activity
S100333_03967	COG2304	oxidoreductase activity
S100333_03968	COG2385	sporulation resulting in formation of a cellular spore
S100333_03969	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100333_03971	COG4836	Membrane
S100333_03973	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S100333_03974	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S100333_03975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S100333_03976	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S100333_03977	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100333_03978	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S100333_03979	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100333_03980	COG0356	it plays a direct role in the translocation of protons across the membrane
S100333_03982	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S100333_03983	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S100333_03984	COG4475	Protein of unknown function (DUF436)
S100333_03985	COG0698	ribose 5-phosphate isomerase
S100333_03986	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100333_03987	COG1971	Probably functions as a manganese efflux pump
S100333_03988	COG0009	L-threonylcarbamoyladenylate synthase
S100333_03989	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S100333_03993	COG2890	protein-(glutamine-N5) methyltransferase activity
S100333_03994	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S100333_03995	COG0346	lactoylglutathione lyase activity
S100333_03996	COG0789	Transcriptional regulator
S100333_03997	COG0679	Auxin Efflux Carrier
S100333_03998	COG0281	malic enzyme
S100333_03999	COG1435	thymidine kinase activity
S100333_04000	COG0254	rRNA binding
S100333_04001	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S100333_04002	COG1494	fructose-1,6-bisphosphatase
S100333_04003	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100333_04005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S100333_04006	COG0191	fructose-bisphosphate aldolase activity
S100333_04007	COG2204	response regulator
S100333_04008	COG4821	SIS domain
S100333_04009	COG2801	Transposase and inactivated derivatives
S100333_04011	COG0504	CTP synthase activity
S100333_04012	COG3343	RNA polymerase activity
S100333_04013	COG1960	acyl-CoA dehydrogenase activity
S100333_04014	COG0247	lactate metabolic process
S100333_04014	COG2181	nitrate reductase activity
S100333_04015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100333_04016	COG4294	response to UV
S100333_04020	COG0018	arginyl-trna synthetase
S100333_04021	COG4506	Protein conserved in bacteria
S100333_04023	COG0535	radical SAM domain protein
S100333_04025	COG1131	(ABC) transporter
S100333_04026	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100333_04027	COG0612	Peptidase, M16
S100333_04028	COG0612	Peptidase, M16
S100333_04030	COG3391	amine dehydrogenase activity
S100333_04031	COG3391	amine dehydrogenase activity
S100333_04032	COG3391	amine dehydrogenase activity
S100333_04033	COG0457	Tetratricopeptide repeat
S100333_04035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S100333_04036	COG0010	Belongs to the arginase family
S100333_04037	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S100333_04038	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100333_04040	COG1994	Peptidase M50
S100333_04041	COG1942	4-Oxalocrotonate Tautomerase
S100333_04042	COG1846	Transcriptional regulator
S100333_04043	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100333_04045	COG0477	Major facilitator Superfamily
S100333_04046	COG1959	2 iron, 2 sulfur cluster binding
S100333_04047	COG3465	dGTPase activity
S100333_04048	COG1078	dGTPase activity
S100333_04049	COG4844	belongs to the
S100333_04051	COG0697	spore germination
S100333_04052	COG0095	Lipoate-protein ligase
S100333_04053	COG0583	DNA-binding transcription factor activity
S100333_04054	COG0280	phosphate acetyltransferase
S100333_04056	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_04057	COG0436	Aminotransferase
S100333_04058	COG2814	Major facilitator Superfamily
S100333_04059	COG0833	amino acid
S100333_04060	COG4187	Peptidase family M20/M25/M40
S100333_04061	COG1012	belongs to the aldehyde dehydrogenase family
S100333_04062	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100333_04064	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
S100333_04065	COG1091	dTDP-4-dehydrorhamnose reductase activity
S100333_04066	COG1088	dTDP-glucose 4,6-dehydratase activity
S100333_04067	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
S100333_04068	COG3980	spore coat polysaccharide biosynthesis protein
S100333_04069	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
S100333_04070	COG2089	acid synthase
S100333_04071	COG0456	acetyltransferase
S100333_04072	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100333_04073	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100333_04074	COG0463	Glycosyl transferase, family 2
S100333_04076	COG2363	Small membrane protein
S100333_04077	COG2233	PERMEase
S100333_04079	COG1012	belongs to the aldehyde dehydrogenase family
S100333_04080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S100333_04081	COG1216	Glycosyl transferase, family 2
S100333_04082	COG0351	phosphomethylpyrimidine kinase
S100333_04084	COG1621	beta-fructofuranosidase activity
S100333_04085	COG1263	PTS System
S100333_04085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_04086	COG2116	formate transmembrane transporter activity
S100333_04087	COG3711	transcriptional antiterminator
S100333_04089	COG1404	Belongs to the peptidase S8 family
S100333_04090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100333_04091	COG0778	Nitroreductase
S100333_04092	COG0772	Belongs to the SEDS family
S100333_04095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100333_04096	COG1845	cytochrome c oxidase, subunit III
S100333_04097	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S100333_04098	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S100333_04099	COG2261	transglycosylase associated protein
S100333_04100	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S100333_04101	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S100333_04102	COG2246	polysaccharide biosynthetic process
S100333_04103	COG1309	transcriptional regulator
S100333_04105	COG3162	membrane
S100333_04106	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_04107	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S100333_04108	COG2837	iron assimilation
S100333_04109	COG2822	iron ion transport
S100333_04110	COG0672	)-iron permease
S100333_04111	COG0352	thiamine-phosphate diphosphorylase activity
S100333_04112	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S100333_04113	COG0583	DNA-binding transcription factor activity
S100333_04114	COG1380	Effector of murein hydrolase LrgA
S100333_04115	COG1346	cytolysis
S100333_04116	COG2814	Major facilitator Superfamily
S100333_04117	COG4895	conserved protein (DUF2196)
S100333_04118	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S100333_04119	COG0346	lactoylglutathione lyase activity
S100333_04121	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_04122	COG1404	Belongs to the peptidase S8 family
S100333_04124	COG1263	PTS System
S100333_04124	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_04125	COG3711	transcriptional antiterminator
S100333_04126	COG1442	glycosyl transferase family 8
S100333_04127	COG5522	Integral membrane protein (intg_mem_TP0381)
S100333_04128	COG1846	Transcriptional regulator
S100333_04129	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100333_04130	COG2234	aminopeptidase activity
S100333_04131	COG2357	RelA SpoT domain protein
S100333_04133	COG2801	Transposase and inactivated derivatives
S100333_04134	COG1575	Belongs to the MenA family. Type 1 subfamily
S100333_04137	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_04138	COG1696	Membrane protein involved in D-alanine export
S100333_04139	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100333_04140	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S100333_04141	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
S100333_04142	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
S100333_04143	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100333_04144	COG1486	melibiose metabolic process
S100333_04145	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100333_04146	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_04147	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_04148	COG3711	transcriptional antiterminator
S100333_04148	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_04150	COG2094	Belongs to the DNA glycosylase MPG family
S100333_04151	COG0753	catalase activity
S100333_04152	COG2814	Major facilitator Superfamily
S100333_04153	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100333_04154	COG1131	(ABC) transporter
S100333_04158	COG1595	DNA-templated transcription, initiation
S100333_04159	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S100333_04160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S100333_04161	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S100333_04162	COG4988	ABC transporter
S100333_04163	COG1294	oxidase, subunit
S100333_04164	COG1271	oxidase subunit
S100333_04165	COG3493	citrate carrier protein
S100333_04166	COG0501	Belongs to the peptidase M48B family
S100333_04168	COG0726	polysaccharide deacetylase
S100333_04169	COG3842	ATPase activity
S100333_04170	COG2508	Transcriptional regulator
S100333_04171	COG1012	belongs to the aldehyde dehydrogenase family
S100333_04172	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_04173	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100333_04175	COG4585	Histidine kinase
S100333_04176	COG2197	response regulator
S100333_04177	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100333_04180	COG4894	glucomannan catabolic process
S100333_04181	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100333_04182	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100333_04183	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_04184	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S100333_04185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S100333_04186	COG2610	gluconate transmembrane transporter activity
S100333_04187	COG0500	methyltransferase
S100333_04188	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100333_04191	COG0693	protein deglycase activity
S100333_04191	COG0753	catalase activity
S100333_04192	COG2851	Citrate transporter
S100333_04193	COG2273	Hydrolase Family 16
S100333_04194	COG3711	transcriptional antiterminator
S100333_04196	COG2270	Major facilitator Superfamily
S100333_04197	COG0513	Belongs to the DEAD box helicase family
S100333_04198	COG3401	FG-GAP repeat protein
S100333_04198	COG2755	lipolytic protein G-D-S-L family
S100333_04215	COG3209	COG3209 Rhs family protein
S100333_04218	COG0697	spore germination
S100333_04223	COG0589	response to stress
S100333_04224	COG2723	6-phospho-beta-galactosidase activity
S100333_04225	COG2723	6-phospho-beta-galactosidase activity
S100333_04228	COG5444	nuclease activity
S100333_04230	COG5444	nuclease activity
S100333_04233	COG3507	Belongs to the glycosyl hydrolase 43 family
S100333_04234	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S100333_04235	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S100333_04236	COG0833	amino acid
S100333_04237	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S100333_04238	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100333_04239	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S100333_04240	COG2390	Transcriptional regulator
S100333_04242	COG3192	ethanolamine utilization protein
S100333_04243	COG2079	MmgE PrpD family protein
S100333_04245	COG1126	abc transporter atp-binding protein
S100333_04246	COG0765	amino acid transport
S100333_04247	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_04250	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S100333_04251	COG0561	phosphatase activity
S100333_04257	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_04258	COG5294	Protein conserved in bacteria
S100333_04259	COG0577	efflux transmembrane transporter activity
S100333_04260	COG1136	(ABC) transporter
S100333_04261	COG2205	protein histidine kinase activity
S100333_04262	COG0745	RESPONSE REGULATOR receiver
S100333_04263	COG0191	fructose-bisphosphate aldolase activity
S100333_04264	COG1082	Xylose isomerase domain protein TIM barrel
S100333_04265	COG1082	Xylose isomerase domain protein TIM barrel
S100333_04266	COG0673	inositol 2-dehydrogenase activity
S100333_04267	COG2814	Major facilitator Superfamily
S100333_04268	COG1082	Xylose isomerase domain protein TIM barrel
S100333_04269	COG3962	Belongs to the TPP enzyme family
S100333_04270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_04272	COG1012	belongs to the aldehyde dehydrogenase family
S100333_04273	COG1349	DNA-binding transcription factor activity
S100333_04274	COG0667	Aldo Keto reductase
S100333_04277	COG2814	Major facilitator Superfamily
S100333_04278	COG2814	Major facilitator Superfamily
S100333_04279	COG0326	Molecular chaperone. Has ATPase activity
S100333_04281	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_04282	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_04291	COG3328	transposase activity
S100333_04292	COG1917	Cupin 2, conserved barrel domain protein
S100333_04293	COG1309	transcriptional regulator
S100333_04294	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_04296	COG2801	Transposase and inactivated derivatives
S100333_04297	COG1846	Transcriptional regulator
S100333_04298	COG1380	Effector of murein hydrolase LrgA
S100333_04299	COG1346	cytolysis
S100333_04300	COG5039	Polysaccharide pyruvyl transferase
S100333_04301	COG1929	Belongs to the glycerate kinase type-1 family
S100333_04302	COG1802	Transcriptional regulator
S100333_04303	COG1070	Carbohydrate kinase
S100333_04304	COG2610	gluconate transmembrane transporter activity
S100333_04305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100333_04306	COG0450	alkyl hydroperoxide reductase
S100333_04307	COG3634	alkyl hydroperoxide reductase activity
S100333_04308	COG2723	6-phospho-beta-galactosidase activity
S100333_04309	COG2190	(PTS) system
S100333_04310	COG2188	Transcriptional regulator
S100333_04312	COG1131	(ABC) transporter
S100333_04313	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
S100333_04315	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_04316	COG3773	Cell wall hydrolase
S100333_04321	COG0210	DNA helicase
S100333_04324	COG2963	transposase activity
S100333_04331	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S100333_04334	COG1063	alcohol dehydrogenase
S100333_04338	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
S100333_04339	COG0456	acetyltransferase
S100333_04340	COG0457	Tetratricopeptide repeat
S100333_04341	COG0457	Tetratricopeptide repeat
S100333_04343	COG0010	Belongs to the arginase family
S100333_04344	COG0833	amino acid
S100333_04345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100333_04349	COG5658	integral membrane protein
S100333_04350	COG0640	Transcriptional regulator
S100333_04351	COG3829	transcription factor binding
S100333_04352	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100333_04353	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S100333_04354	COG4853	Protein conserved in bacteria
S100333_04355	COG4863	YycH protein
S100333_04356	COG5002	protein histidine kinase activity
S100333_04357	COG0745	RESPONSE REGULATOR receiver
S100333_04363	COG0346	lactoylglutathione lyase activity
S100333_04364	COG0305	Participates in initiation and elongation during chromosome replication
S100333_04367	COG3093	addiction module antidote protein HigA
S100333_04368	COG2807	transmembrane transport
S100333_04369	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100333_04370	COG0359	binds to the 23S rRNA
S100333_04371	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
S100333_04372	COG4241	membrane
S100333_04373	COG4241	membrane
S100333_04375	COG5577	PFAM Coat F domain
S100333_04376	COG5577	PFAM Coat F domain
S100333_04377	COG1733	regulation of RNA biosynthetic process
S100333_04378	COG1227	inorganic diphosphatase activity
S100333_04381	COG2271	Major facilitator Superfamily
S100333_04382	COG4978	Transcriptional regulator
S100333_04382	COG0789	Transcriptional regulator
S100333_04384	COG4319	ketosteroid isomerase
S100333_04385	COG1357	PFAM Pentapeptide repeats (8 copies)
S100333_04386	COG2814	Major facilitator Superfamily
S100333_04387	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_04388	COG1846	Transcriptional regulator
S100333_04389	COG2153	protein acetylation
S100333_04390	COG2364	Membrane
S100333_04391	COG0456	acetyltransferase
S100333_04392	COG2315	Protein conserved in bacteria
S100333_04393	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100333_04394	COG1331	Highly conserved protein containing a thioredoxin domain
S100333_04395	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
S100333_04396	COG1331	Highly conserved protein containing a thioredoxin domain
S100333_04397	COG1266	CAAX protease self-immunity
S100333_04398	COG0477	Major facilitator Superfamily
S100333_04398	COG2814	Major facilitator Superfamily
S100333_04399	COG0346	lactoylglutathione lyase activity
S100333_04400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100333_04401	COG0542	response to heat
S100333_04403	COG1609	Transcriptional regulator
S100333_04404	COG0708	Exodeoxyribonuclease III
S100333_04405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S100333_04406	COG0629	single-stranded DNA binding
S100333_04407	COG0360	Binds together with S18 to 16S ribosomal RNA
S100333_04408	COG0012	GTP binding
S100333_04409	COG0243	molybdopterin cofactor binding
S100333_04410	COG4481	Protein conserved in bacteria
S100333_04411	COG3949	Membrane
S100333_04413	COG1475	DNA binding
S100333_04414	COG1192	Involved in chromosome partitioning
S100333_04416	COG1475	DNA binding
S100333_04417	COG0357	Ribosomal RNA small subunit methyltransferase G
S100333_04418	COG0445	tRNA wobble uridine modification
S100333_04419	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S100333_04420	COG1847	R3H domain protein
S100333_04421	COG0706	membrane insertase activity
S100333_04422	COG0594	ribonuclease P activity
S100333_04428	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100333_04429	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100333_04438	COG0457	Tetratricopeptide repeat
S100333_04440	COG2801	Transposase and inactivated derivatives
S100333_04470	COG0791	NLP P60 protein
S100333_04470	COG3883	PFAM NLP P60 protein
S100333_04482	COG0629	single-stranded DNA binding
S100333_04485	COG0582	viral genome integration into host DNA
S100333_04491	COG1793	dna ligase
S100333_04494	COG1525	nuclease
S100333_04518	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII