locus-tag class description S100757_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) S100757_00002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) S100757_00003 ENOG410848D S4 domain protein YaaA S100757_00006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S100757_00007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S100757_00014 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) S100757_00016 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) S100757_00017 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) S100757_00018 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) S100757_00020 ENOG4105ZMH deoxynucleoside kinase S100757_00022 ENOG4105VRS hydrolase family 18 S100757_00023 ENOG4105GTG Isochorismatase S100757_00024 ENOG4108Z6B deaminase S100757_00025 ENOG4105C6E dna polymerase iii S100757_00026 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) S100757_00027 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) S100757_00029 ENOG41067KS pro-sigma K processing S100757_00037 ENOG4105CDW Resistance protein S100757_00038 ENOG4105CXN decarboxylase S100757_00039 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) S100757_00040 ENOG4105X0R protein from nitrogen regulatory protein P-II S100757_00041 ENOG4105XVJ Protein of unknown function (DUF327) S100757_00042 ENOG4105FA2 dna polymerase iii S100757_00043 ENOG4105MA4 psp1 domain protein S100757_00044 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) S100757_00045 ENOG41060K3 Methyltransferase S100757_00046 ENOG4105VC4 domain protein S100757_00047 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) S100757_00048 ENOG4105KRN Transcriptional regulator, abrb family S100757_00049 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) S100757_00050 ENOG4105F8V Hydrolase, tatD family S100757_00051 ENOG41069ER domain protein S100757_00053 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) S100757_00054 ENOG4105XFA sporulation peptidase YabG S100757_00055 ENOG4105W42 Veg protein S100757_00056 ENOG4105XEW small acid-soluble spore protein S100757_00057 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) S100757_00058 ENOG4105DFT pur operon repressor S100757_00059 ENOG4105KME endoribonuclease L-psp S100757_00060 ENOG4105K4W Could be involved in septation (By similarity) S100757_00061 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) S100757_00062 ENOG4105C5T Phosphoribosyl pyrophosphate synthase S100757_00063 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) S100757_00064 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) S100757_00066 ENOG4108JA2 transcriptioN-repair coupling factor S100757_00067 ENOG4108M14 stage v sporulation protein t S100757_00069 ENOG4108IY2 MazG family S100757_00070 ENOG41082I2 s4 domain protein S100757_00071 ENOG4105VYY sporulation protein yabp S100757_00074 ENOG41060GV RNA binding s1 domain protein S100757_00080 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) S100757_00081 ENOG4108UGV hypoxanthine phosphoribosyltransferase S100757_00082 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) S100757_00084 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) S100757_00085 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase S100757_00086 ENOG4105C6T cysteine synthase S100757_00087 ENOG4105CRQ synthase (Component I) S100757_00088 ENOG4105DDQ anthranilate synthase S100757_00089 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 S100757_00090 ENOG4105EEI dihydropteroate synthase S100757_00091 ENOG4105KRF dihydroneopterin aldolase S100757_00092 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase S100757_00094 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) S100757_00095 ENOG4105CRK lysyL-tRNA synthetase S100757_00112 ENOG4108Z0C Uvrb UvrC protein S100757_00113 ENOG41066A3 ATP guanido phosphotransferase S100757_00115 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) S100757_00116 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) S100757_00117 ENOG4105CTP PilT protein domain protein S100757_00118 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) S100757_00119 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) S100757_00120 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) S100757_00121 ENOG4105D7W serine acetyltransferase S100757_00122 ENOG4105C8N cysteinyl-tRNA synthetase S100757_00123 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) S100757_00124 ENOG4105C2N RNA methyltransferase TrmH family group 3 S100757_00125 ENOG4105M0M Tetracycline resistance protein S100757_00128 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) S100757_00129 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) S100757_00131 ENOG4108VZM 50s ribosomal protein L10 S100757_00132 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) S100757_00133 ENOG4107Y49 methyltransferase S100757_00134 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S100757_00135 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S100757_00136 ENOG4105XPM ribosomal protein S100757_00137 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) S100757_00138 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) S100757_00139 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) S100757_00140 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) S100757_00141 ENOG4107SKW Inherit from COG: Alpha beta hydrolase S100757_00142 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) S100757_00143 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) S100757_00144 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) S100757_00145 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) S100757_00146 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity S100757_00147 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) S100757_00148 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) S100757_00149 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) S100757_00150 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) S100757_00151 ENOG41082SA 50s ribosomal protein l29 S100757_00152 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal S100757_00153 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) S100757_00155 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits S100757_00157 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) S100757_00158 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) S100757_00159 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) S100757_00160 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) S100757_00161 ENOG4105VPB 50S ribosomal protein L30 S100757_00162 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) S100757_00163 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) S100757_00165 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) S100757_00166 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) S100757_00168 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits S100757_00169 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) S100757_00170 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S100757_00171 ENOG4108ZT0 50S ribosomal protein l17 S100757_00172 ENOG4108JJB ABC transporter S100757_00173 ENOG4108JJB ABC transporter S100757_00174 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) S100757_00175 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) S100757_00176 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) S100757_00177 ENOG4108UJD 30S ribosomal protein S9 S100757_00178 ENOG4108I0C methyltransferase S100757_00181 ENOG4105D1F ATP-binding protein S100757_00184 ENOG4108NMV polysaccharide deacetylase S100757_00200 ENOG4105CHH sulfate transporter S100757_00203 ENOG4108SA1 esterase S100757_00207 ENOG410874W AraC family transcriptional regulator S100757_00208 ENOG4105EHZ conserved protein UCP016719 S100757_00209 ENOG4105D17 glycoside hydrolase, family 3 domain protein S100757_00213 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate S100757_00215 ENOG4105EWC Purine nucleoside phosphorylase S100757_00221 ENOG4105EMN RNA polymerase sigma factor S100757_00223 ENOG4105C8B TIGR00159 family S100757_00224 ENOG4107U5W ybbr family S100757_00225 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) S100757_00226 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) S100757_00227 ENOG4105D03 DNA-3-methyladenine glycosylase II S100757_00229 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S100757_00230 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S100757_00231 ENOG4108TWJ NADH dehydrogenase subunit 5 S100757_00235 ENOG4105GPN Uncharacterized conserved protein (DUF2294) S100757_00236 ENOG4105WAB arsR family transcriptional regulator S100757_00237 ENOG4108RWP Major Facilitator Superfamily protein S100757_00238 ENOG4108RWP Major Facilitator Superfamily protein S100757_00244 ENOG4105G0J serine threonine protein kinase S100757_00246 ENOG4106K80 S100757_00248 ENOG4106DDH Sporulation-specific SASP protein S100757_00250 ENOG4108HWY Beta-lactamase S100757_00251 ENOG4107E6A Cytochrome p-450 S100757_00253 ENOG4107QTZ amino acid S100757_00254 ENOG4107VXM glycerophosphoryl diester phosphodiesterase S100757_00255 ENOG4105CXY transporter S100757_00257 ENOG410645S MarR family Transcriptional regulator S100757_00258 ENOG4105DCM major facilitator superfamily S100757_00259 ENOG410631K Membrane S100757_00260 ENOG4106AXJ AraC family transcriptional regulator S100757_00264 ENOG4105GIG S100757_00265 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR S100757_00266 ENOG4108TCS Glutamyl endopeptidase S100757_00268 ENOG4108WC5 Alpha Beta Hydrolase Fold protein S100757_00269 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase S100757_00270 ENOG4107ZTW SNARE associated Golgi S100757_00275 ENOG4105C72 UPF0176 protein S100757_00277 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane S100757_00278 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) S100757_00279 ENOG4108X79 transcriptional regulator S100757_00281 ENOG4105CM2 brancheD-chain amino acid aminotransferase S100757_00282 ENOG4108IQI permease S100757_00283 ENOG4108J5H Homocysteine s-methyltransferase S100757_00285 ENOG4105CSV Glutaminase S100757_00288 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase S100757_00289 ENOG4105C26 Dehydrogenase S100757_00290 ENOG4105DJB Major Facilitator Superfamily S100757_00291 ENOG4105EQX glucarate dehydratase S100757_00292 ENOG41073TP transcriptional regulator S100757_00293 ENOG4105CTX dehydratase S100757_00296 ENOG4106UX7 integral membrane protein S100757_00297 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S100757_00303 ENOG4105MUA Resistance protein S100757_00304 ENOG4105DGI Alkaline phosphatase S100757_00305 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S100757_00306 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S100757_00307 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) S100757_00308 ENOG4107EPV Aminotransferase class V S100757_00309 ENOG4105C0R drug resistance transporter emrb qaca subfamily S100757_00310 ENOG4105J7D transcriptional regulator S100757_00311 ENOG4107RB3 L-asparaginase S100757_00312 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold S100757_00314 ENOG41060AI SEC-C motif S100757_00316 ENOG4107Y7X LytTR S100757_00317 ENOG4108IUW ABC transporter S100757_00318 ENOG4108SDH ABC, transporter S100757_00319 ENOG4107SET aldo keto reductase S100757_00325 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S100757_00327 ENOG4105DSE periplasmic solute binding protein S100757_00328 ENOG4105DIK (ABC) transporter S100757_00330 ENOG4105DEN Luciferase family S100757_00331 ENOG4108N0M stress protein S100757_00332 ENOG4106FN3 tellurium resistance protein S100757_00333 ENOG4106FN3 tellurium resistance protein S100757_00334 ENOG4107TS3 membrane protein, TerC S100757_00335 ENOG4108TTB tellurium resistance protein S100757_00337 ENOG41079KZ Major Facilitator Superfamily S100757_00338 ENOG4107XZQ multidrug resistance protein S100757_00339 ENOG4108A65 Transcriptional regulator S100757_00340 ENOG4108IJ7 Glycine betaine S100757_00341 ENOG4107SQ8 Glycine betaine S100757_00347 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) S100757_00354 ENOG4105EIG urea carboxylase-associated protein 1 S100757_00355 ENOG4107RA1 nh(3)-dependent nad( ) synthetase S100757_00356 ENOG4105I1F Resistance protein S100757_00357 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) S100757_00358 ENOG41089UC methyltransferase, type 11 S100757_00359 ENOG4105C5Q Transcriptional regulator S100757_00360 ENOG4105I82 acetyl xylan esterase S100757_00361 ENOG410756H nucleotidyltransferase S100757_00363 ENOG4105C26 Dehydrogenase S100757_00364 ENOG4105CK7 Sodium proline symporter S100757_00365 ENOG4107YHD transcriptional regulator S100757_00367 ENOG4108PJD permease S100757_00368 ENOG4105U6C Alpha beta hydrolase fold protein S100757_00370 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S100757_00371 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit S100757_00372 ENOG4108IFG nitrite reductase, (NAD(P)H) S100757_00373 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) S100757_00377 ENOG4105S7A ErfK ybiS ycfS ynhG family protein S100757_00378 ENOG4105CKI cobalamin synthesis protein S100757_00379 ENOG4105E5Q amino acid AbC transporter S100757_00380 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein S100757_00382 ENOG4105HHM rdd domain containing protein S100757_00384 ENOG4105K56 Transcriptional regulator S100757_00386 ENOG4108VEN abc transporter atp-binding protein S100757_00387 ENOG4105CS2 ec 3.2.1.21 S100757_00390 ENOG4105C8Q Methyl-accepting chemotaxis S100757_00391 ENOG41080HJ 6-phospho 3-hexuloisomerase S100757_00392 ENOG4108VA3 3-hexulose-6-phosphate synthase S100757_00393 ENOG4105KVH Transcriptional regulator S100757_00394 ENOG4105CEY Amp-dependent synthetase and ligase S100757_00400 ENOG4105SX7 Transporter S100757_00402 ENOG4105W8Z 4'-phosphopantetheinyl transferase S100757_00404 ENOG4105CDA abc transporter atp-binding protein S100757_00405 ENOG4105DRP amino acid AbC transporter S100757_00407 ENOG4106P55 Transcriptional regulator S100757_00408 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase S100757_00409 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) S100757_00410 ENOG41069ZX S100757_00411 ENOG41069ZX S100757_00413 ENOG4105DUX Transporter S100757_00416 ENOG4105E1K spore germination protein S100757_00420 ENOG4107WD8 ABC transporter, permease S100757_00421 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S100757_00422 ENOG4105BZU Histidine kinase S100757_00426 ENOG4105CFH Aspartokinase S100757_00427 ENOG4105DHS permease protein S100757_00428 ENOG4105CM4 permease protein S100757_00429 ENOG4108IPW abc transporter atp-binding protein S100757_00433 ENOG4105R8C Transcriptional regulator S100757_00434 ENOG4108DBC nitroreductase S100757_00435 ENOG41067V3 Antibiotic biosynthesis monooxygenase S100757_00436 ENOG4105YVS arsR family transcriptional regulator S100757_00438 ENOG4108JPW Aminotransferase S100757_00439 ENOG4105C26 Dehydrogenase S100757_00441 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S100757_00442 ENOG4105KTB nuclear export factor GLE1 S100757_00443 ENOG4108T5E Copper resistance protein S100757_00444 ENOG4108ZYE Transcriptional regulator S100757_00449 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S100757_00451 ENOG4108ZX0 Signal peptidase I S100757_00456 ENOG4105E7W lamb ycsf family protein S100757_00457 ENOG4105C5A transporter S100757_00458 ENOG4105CFM UPF0317 protein S100757_00459 ENOG4105P4J Allophanate hydrolase, subunit 1 S100757_00461 ENOG4107258 Transcriptional regulator S100757_00462 ENOG4105XJB lipolytic protein G-D-S-L family S100757_00464 ENOG41061CK Antibiotic biosynthesis monooxygenase S100757_00465 ENOG4107RVG penicillin-binding protein S100757_00466 ENOG4107QM2 Aldo Keto reductase S100757_00467 ENOG4105ETD TRANSCRIPTIONal S100757_00469 ENOG4105HMZ Methyltransferase S100757_00470 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S100757_00473 ENOG410606W general stress protein S100757_00475 ENOG4105VCH membrane S100757_00477 ENOG4105C9U ATP-dependent DNA helicase RecQ S100757_00480 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) S100757_00481 ENOG4107R8N Glycosyl transferase, family 2 S100757_00483 ENOG4105C0X amino acid S100757_00491 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) S100757_00493 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) S100757_00494 ENOG4105EU9 S100757_00495 ENOG4105QVS general stress protein S100757_00496 ENOG41082W1 Cupin 2, conserved barrel domain protein S100757_00499 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit S100757_00500 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism S100757_00501 ENOG4108MRH transcriptional regulatory protein S100757_00502 ENOG4107QJT sodium dicarboxylate symporter S100757_00503 ENOG4106F5Q Membrane S100757_00505 ENOG4105CJ1 ABC, transporter S100757_00508 ENOG4105FDT acyl-CoA dehydrogenase S100757_00512 ENOG4105SZ6 Thioredoxin S100757_00513 ENOG4105CPF Cell wall formation (By similarity) S100757_00514 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) S100757_00515 ENOG4105C1J atp-dependent rna helicase S100757_00516 ENOG410905X membrane-flanked domain protein S100757_00517 ENOG4105CKV Membrane S100757_00519 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) S100757_00520 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein S100757_00521 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S100757_00523 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) S100757_00524 ENOG4107MMM Anti-sigma-factor antagonist S100757_00525 ENOG4105FUA antagonist S100757_00526 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase S100757_00527 ENOG4107SGM protein serine threonine phosphatase S100757_00528 ENOG4105WN5 stage II sporulation protein S100757_00529 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) S100757_00531 ENOG41064BQ Phosphatase S100757_00543 ENOG41085FC arsR family transcriptional regulator S100757_00544 ENOG41082YX Transcriptional regulator, arsr family S100757_00545 ENOG4107R5R arsenical pump membrane protein S100757_00546 ENOG4108UXE Protein tyrosine phosphatase S100757_00547 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) S100757_00548 ENOG41068WC Domain of unknown function (DUF955) S100757_00549 ENOG4108IMY Transcriptional regulator S100757_00553 ENOG4108RYM conjugative transposon protein S100757_00554 ENOG4106BHR ftsk SpoIIIE family protein S100757_00555 ENOG4106128 DNA-binding helix-turn-helix protein S100757_00563 ENOG4105P1M Domain of unknown function (DUF1874) S100757_00565 ENOG4105K4H Nlp p60 protein S100757_00572 ENOG4107V2S Transcriptional regulator S100757_00575 ENOG4106BHF S100757_00576 ENOG4105VZ8 Transcriptional regulator S100757_00581 ENOG4108V4B ThiJ pfpI S100757_00582 ENOG4105VEQ Cold shock protein S100757_00583 ENOG4108VJ1 Transcriptional regulator (CarD family S100757_00585 ENOG4108MCI Transcriptional regulator, ARAC family S100757_00586 ENOG4108UZ3 Transporter S100757_00587 ENOG41086D8 Transcriptional regulator S100757_00588 ENOG4107U9B transcriptional regulator S100757_00589 ENOG4105DXI Major Facilitator superfamily S100757_00590 ENOG4105DXI Major Facilitator superfamily S100757_00592 ENOG4105CZ9 Domain of unknown function (DU1801) S100757_00593 ENOG4105GIG S100757_00595 ENOG4105KRI phosphocarrier protein (HPr S100757_00596 ENOG4105ST3 Transcriptional regulator S100757_00597 ENOG4105T38 integral membrane protein S100757_00598 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S100757_00599 ENOG4108ZMQ domain protein S100757_00600 ENOG4105MJ9 esterase S100757_00601 ENOG4107Z6X Transcriptional regulator S100757_00603 ENOG4105KVH Transcriptional regulator S100757_00604 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein S100757_00605 ENOG4105EQ0 Major Facilitator superfamily S100757_00606 ENOG4108JGH Tetr family transcriptional regulator S100757_00607 ENOG41082YX Transcriptional regulator, arsr family S100757_00608 ENOG4107R5R arsenical pump membrane protein S100757_00609 ENOG4105Z7P Acetyltransferase (GNAT) family S100757_00610 ENOG4107Y9U Membrane S100757_00612 ENOG4105DY8 decarboxylase S100757_00613 ENOG4108SQ9 flavin reductase domain protein, FMN-binding S100757_00614 ENOG4108ZHR arsR family transcriptional regulator S100757_00615 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) S100757_00617 ENOG4105ENE Histidine kinase S100757_00618 ENOG4108VB1 regulatoR S100757_00619 ENOG4105EYF MMPL domain protein S100757_00620 ENOG4108UQV Membrane S100757_00621 ENOG4108Z5V transcriptional regulator, merr family S100757_00622 ENOG41076HS cation diffusion facilitator family transporter S100757_00623 ENOG4108TVJ Nitroreductase S100757_00624 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase S100757_00625 ENOG4108VGI doxx family S100757_00626 ENOG4105XXY Thioredoxin S100757_00630 ENOG410900G Protein of unknown function (DUF421) S100757_00631 ENOG4108QY0 Membrane S100757_00635 ENOG4105PF9 Transcriptional regulator S100757_00637 ENOG4105WQG acetyltransferase S100757_00639 ENOG4105C85 amino acid S100757_00641 ENOG41062A4 Transcriptional regulator S100757_00642 ENOG4105EYF MMPL domain protein S100757_00643 ENOG4108TVJ Nitroreductase S100757_00644 ENOG4105FS7 Transcriptional regulator S100757_00645 ENOG4105C2C drug resistance transporter, Bcr CflA S100757_00647 ENOG4105DRR Transcriptional regulator, GntR family S100757_00648 ENOG4105VRS hydrolase family 18 S100757_00651 ENOG4105G6Z alkaline phosphatase S100757_00652 ENOG4108ZMX Domain of unknown function (DU1801) S100757_00654 ENOG4108YM7 Gcn5-related n-acetyltransferase S100757_00655 ENOG4107TVP HD domain protein S100757_00656 ENOG41090UD (LipO)protein S100757_00657 ENOG4105F27 Major Facilitator S100757_00658 ENOG4105VZJ PTS System S100757_00659 ENOG4105VCP PTS System S100757_00660 ENOG4105CK1 PTS System S100757_00661 ENOG4105CS2 ec 3.2.1.21 S100757_00662 ENOG4108TZY GntR Family Transcriptional Regulator S100757_00663 ENOG4105EVU fructokinase S100757_00664 ENOG4105DG6 mannose-6-phosphate isomerase S100757_00665 ENOG4105D3P Mannan endo-1,4-beta-mannosidase S100757_00674 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) S100757_00675 ENOG4105K8N protein family UPF0079, ATPase S100757_00676 ENOG41072GX Peptidase M22 Glycoprotease S100757_00677 ENOG410801F ribosomal-protein-alanine acetyltransferase S100757_00678 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S100757_00679 ENOG4105C5H ABC transporter S100757_00680 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) S100757_00681 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) S100757_00682 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S100757_00683 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S100757_00685 ENOG4108TYN CAAX amino terminal protease family protein S100757_00686 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) S100757_00687 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) S100757_00689 ENOG4105PGZ NB-ARC domain S100757_00690 ENOG4105CPQ Dehydrogenase S100757_00691 ENOG4105CT4 transporter S100757_00693 ENOG41087YS Phage shock protein A S100757_00694 ENOG4105DQX Zinc finger domain S100757_00695 ENOG4108WV1 Pfam:DUF477 S100757_00697 ENOG4108ZMR Ion transport 2 domain-containing protein S100757_00698 ENOG4107QNK )-transporter S100757_00704 ENOG4107YUH hydrolase S100757_00706 ENOG4107STQ Multicopper oxidase S100757_00707 ENOG4105C85 amino acid S100757_00709 ENOG4105C7R Atpase associated with various cellular activities aaa_3 S100757_00715 ENOG4105C7N Xanthine uracil vitamin C permease S100757_00720 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) S100757_00721 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit S100757_00722 ENOG4105C83 adenylosuccinate lyase S100757_00723 ENOG4105C8V SAICAR synthetase S100757_00724 ENOG4105VR9 phosphoribosylformylglycinamidine synthase S100757_00725 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I S100757_00726 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii S100757_00728 ENOG4105CXB phosphoribosylaminoimidazole synthetase S100757_00729 ENOG4108V3E phosphoribosylglycinamide formyltransferase S100757_00730 ENOG4105DC1 bifunctional purine biosynthesis protein purh S100757_00731 ENOG4105C12 Phosphoribosylglycinamide synthetase S100757_00733 ENOG4105DVH amino acid S100757_00736 ENOG4108R5T secreted protein S100757_00737 ENOG4105KGF protein, YerC YecD S100757_00738 ENOG4105CBC glutamate synthase S100757_00739 ENOG4105CBC glutamate synthase S100757_00741 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) S100757_00742 ENOG4105C4R Atp-dependent dna helicase S100757_00743 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) S100757_00745 ENOG4105CRN Aminoglycoside phosphotransferase S100757_00746 ENOG4105KT7 mgtC SapB transporter S100757_00747 ENOG4105CK7 Sodium proline symporter S100757_00748 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S100757_00749 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) S100757_00750 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S100757_00751 ENOG4108IG5 Transcriptional regulator S100757_00753 ENOG4105CBD Diacylglycerol kinase S100757_00754 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S100757_00771 ENOG4108HFV S100757_00775 ENOG4105CDY transcriptional regulatory protein S100757_00777 ENOG4105M4P Tetr family transcriptional regulator S100757_00778 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein S100757_00779 ENOG4107S9F NmrA family S100757_00782 ENOG4105WEF catalase S100757_00783 ENOG4105M18 -acetyltransferase S100757_00786 ENOG4105C2F Histidine kinase S100757_00787 ENOG4105EQD regulatoR S100757_00788 ENOG410769Z extracellular solute-binding protein family 1 S100757_00789 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component S100757_00790 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component S100757_00791 ENOG4105F5H Glycosyl Hydrolase Family 88 S100757_00792 ENOG41075H3 AraC family transcriptional regulator S100757_00793 ENOG4107TDE lipolytic protein G-D-S-L family S100757_00796 ENOG4105CX8 fg-gap repeat protein S100757_00797 ENOG4105CX8 fg-gap repeat protein S100757_00798 ENOG4107TDE lipolytic protein G-D-S-L family S100757_00800 ENOG4105EKC S100757_00801 ENOG4105E0S extracellular solute-binding protein family 1 S100757_00803 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component S100757_00804 ENOG4105F8D glycoside hydrolase family 4 S100757_00805 ENOG4105H67 Protein of unknown function (DUF421) S100757_00806 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) S100757_00807 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily S100757_00810 ENOG4106I4J membrane S100757_00811 ENOG4108PCN EamA-like transporter family S100757_00812 ENOG41082F9 transcriptional regulator S100757_00813 ENOG41061H0 Monooxygenase S100757_00814 ENOG4108R1P S100757_00815 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S100757_00816 ENOG4105E0M Sulfatase S100757_00817 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase S100757_00819 ENOG41090R9 glycosyltransferase S100757_00820 ENOG4107R51 Glycosyl transferase, family 2 S100757_00821 ENOG41090R9 glycosyltransferase S100757_00822 ENOG4105EU0 Major facilitator Superfamily S100757_00824 ENOG4105CUB amino acid S100757_00825 ENOG4105C26 Dehydrogenase S100757_00826 ENOG4105FKZ Methyl-accepting chemotaxis S100757_00827 ENOG4105C5H ABC transporter S100757_00829 ENOG4107SWG transcriptional regulator MERR family S100757_00830 ENOG4105DXB Major Facilitator superfamily S100757_00832 ENOG4105C5H ABC transporter S100757_00833 ENOG4105FDU atp-dependent rna helicase S100757_00835 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein S100757_00836 ENOG4105E0A ABC, transporter S100757_00837 ENOG4108U1V ABC transporter, permease S100757_00838 ENOG4105DQ5 transport system permease protein S100757_00839 ENOG4108HUF Transporter S100757_00842 ENOG4108J20 pectate lyase S100757_00843 ENOG4107QPK )-transporter S100757_00845 ENOG4108MRH transcriptional regulatory protein S100757_00850 ENOG410855V Acylphosphatase S100757_00851 ENOG4108RPX mosc domain containing protein S100757_00855 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) S100757_00861 ENOG4105E1K spore germination protein S100757_00862 ENOG4105C5Y PTS System S100757_00863 ENOG4105CG3 alpha amylase, catalytic region S100757_00864 ENOG4107414 GntR family transcriptional regulator S100757_00865 ENOG4108RCM Nitroreductase S100757_00866 ENOG4105CGH 5'-nucleotidase S100757_00867 ENOG4107RKG DJ-1/PfpI family S100757_00870 ENOG4105KJF protein tyrosine phosphatase S100757_00872 ENOG4107U9T Pfam:Ribonuclease_BN S100757_00873 ENOG4108ISG Major Facilitator S100757_00874 ENOG4105UPD Calcium Proton S100757_00876 ENOG4105D8X mechanosensitive ion channel S100757_00880 ENOG4106KE4 Dehydrogenase S100757_00881 ENOG4105D7N magnesium and cobalt transport protein CorA S100757_00883 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S100757_00888 ENOG4107RUY (E1 component), alpha subunit S100757_00890 ENOG4107QKR Dehydrogenase S100757_00892 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family S100757_00893 ENOG41069DP small acid-soluble spore protein S100757_00894 ENOG4105KK4 UPF0060 membrane protein S100757_00900 ENOG4105F8D glycoside hydrolase family 4 S100757_00901 ENOG4108Q3X Transcriptional regulator S100757_00902 ENOG4105CI1 PTS System S100757_00904 ENOG4105BZ1 (ABC) transporter S100757_00905 ENOG4105BZ1 (ABC) transporter S100757_00907 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase S100757_00908 ENOG4105BZU Histidine kinase S100757_00909 ENOG4105WH1 Two component transcriptional regulator luxr family S100757_00910 ENOG4105CJ1 ABC, transporter S100757_00911 ENOG41090VJ ABC-2 type transporter S100757_00912 ENOG4108KYE ABC-2 type transporter S100757_00913 ENOG4105U3E Transcriptional regulator S100757_00914 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold S100757_00915 ENOG4105H93 Acyltransferase family S100757_00916 ENOG4105YA8 Transcriptional regulator S100757_00917 ENOG4107Y80 Major Facilitator superfamily S100757_00918 ENOG4108YYS metal-dependent hydrolase (By similarity) S100757_00919 ENOG4105C0R drug resistance transporter emrb qaca subfamily S100757_00920 ENOG410834F Transcriptional regulator S100757_00922 ENOG4108MES Periplasmic binding protein S100757_00923 ENOG4105DQ5 transport system permease protein S100757_00924 ENOG4108IHU transport system permease protein S100757_00925 ENOG4105JAB phenazine biosynthesis protein, phzf family S100757_00926 ENOG4107Y03 Nitroreductase S100757_00929 ENOG4105ECP epimerase S100757_00932 ENOG4105F27 Major Facilitator S100757_00936 ENOG4106AKJ S100757_00937 ENOG4105D74 hydrolase S100757_00938 ENOG4105CKK Glycosyl transferase, family 2 S100757_00939 ENOG4105EJV Membrane S100757_00940 ENOG41067AE Membrane-bound metal-dependent hydrolase S100757_00941 ENOG4105CEN a g-specific adenine glycosylase S100757_00942 ENOG4106BXE S100757_00943 ENOG4105CAN Short-chain dehydrogenase reductase Sdr S100757_00946 ENOG4105EVI UPF0374 protein S100757_00947 ENOG4105BZ1 (ABC) transporter S100757_00948 ENOG4107NBY Membrane S100757_00950 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S100757_00951 ENOG4105G5W regulator Fur family S100757_00973 ENOG4108N23 SpoOM-related protein S100757_00975 ENOG4105EC3 peptidase S51, dipeptidase E S100757_00976 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) S100757_00979 ENOG4105E2Y ABC, transporter S100757_00980 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein S100757_00981 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component S100757_00982 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) S100757_00984 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S100757_00985 ENOG4107D63 S100757_00986 ENOG4105VZ8 Transcriptional regulator S100757_00989 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) S100757_00991 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) S100757_00995 ENOG4105CYN Serine protein kinase S100757_00996 ENOG4106AKX UPF0229 protein S100757_00997 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes S100757_00998 ENOG4105CW7 secretion protein, HlyD family S100757_00999 ENOG4105C0R drug resistance transporter emrb qaca subfamily S100757_01000 ENOG4105CS1 NAD(P)H quinone oxidoreductase S100757_01003 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family S100757_01004 ENOG4105CZV ABC transporter S100757_01005 ENOG4105CJ1 ABC, transporter S100757_01006 ENOG4108TU7 Inherit from COG: (ABC) transporter S100757_01007 ENOG4105VEQ Cold shock protein S100757_01009 ENOG4105BZU Histidine kinase S100757_01016 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) S100757_01026 ENOG4105P1M Domain of unknown function (DUF1874) S100757_01028 ENOG4105K4H Nlp p60 protein S100757_01042 ENOG4108YBP pseudouridine synthase S100757_01044 ENOG41080XP Cbs domain S100757_01045 ENOG4107YBY Hydrolase S100757_01046 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S100757_01047 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S100757_01048 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator S100757_01050 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) S100757_01051 ENOG4105C6V Glycerol-3-phosphate dehydrogenase S100757_01053 ENOG4105BZU Histidine kinase S100757_01054 ENOG4105WH1 Two component transcriptional regulator luxr family S100757_01061 ENOG4105ED1 spovr family S100757_01062 ENOG4105G6Z alkaline phosphatase S100757_01065 ENOG4105BZN citrate synthase S100757_01066 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S100757_01067 ENOG4105CUB amino acid S100757_01068 ENOG4105C8J )-transporter S100757_01069 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S100757_01072 ENOG4105J37 S100757_01073 ENOG4108AEY RNA polymerase sigma factor S100757_01074 ENOG4108FN7 Aldo keto reductase S100757_01075 ENOG4105F6E Acyl-transferase S100757_01076 ENOG4105C37 (CBS) domain S100757_01078 ENOG4105CHM Aminotransferase S100757_01079 ENOG4105C37 (CBS) domain S100757_01081 ENOG4105WMR Protein CrcB homolog S100757_01082 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S100757_01084 ENOG4105D64 Mechanosensitive ion channel S100757_01085 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) S100757_01086 ENOG4107VMI polysaccharide deacetylase S100757_01087 ENOG4105F0I Aminotransferase S100757_01090 ENOG4105BZ1 (ABC) transporter S100757_01091 ENOG4105BZ1 (ABC) transporter S100757_01095 ENOG410839P S100757_01097 ENOG4106MP8 UPF0754 membrane protein S100757_01098 ENOG4105WZB UPF0342 protein S100757_01099 ENOG4105F1N DNA alkylation repair S100757_01101 ENOG4105D4P Coproporphyrinogen iii oxidase S100757_01102 ENOG4107S91 Sodium hydrogen exchanger S100757_01103 ENOG4105NCW Trka-c domain protein S100757_01105 ENOG4105CGU Enoyl-CoA hydratase S100757_01107 ENOG4108IUX (ABC) transporter S100757_01108 ENOG4105RHA ABC transporter, permease S100757_01109 ENOG4107VRP DNA repair exonuclease S100757_01110 ENOG4106D4I domain protein S100757_01111 ENOG4105EQI Metal Dependent Phosphohydrolase S100757_01113 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) S100757_01119 ENOG4105NBU tryptophan transport protein S100757_01120 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) S100757_01121 ENOG4105K59 histidine triad (HIT) protein S100757_01128 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation S100757_01129 ENOG4105BZ4 penicillin-binding protein S100757_01130 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) S100757_01131 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) S100757_01132 ENOG4105C1Q protoporphyrinogen oxidase S100757_01134 ENOG4105ECB domain protein S100757_01136 ENOG41090T1 Membrane S100757_01138 ENOG4105DER m42 family S100757_01141 ENOG4108RQ5 Beta-lactamase domain-containing protein S100757_01142 ENOG4105DF9 Lipoate-protein, ligase S100757_01144 ENOG4105CEY Amp-dependent synthetase and ligase S100757_01146 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 S100757_01148 ENOG4105KD7 acetyltransferase S100757_01150 ENOG4108HUF Transporter S100757_01151 ENOG4107TB6 phosphoglycerate mutase S100757_01153 ENOG4107F3J Amp-dependent synthetase and ligase S100757_01154 ENOG4107ZYJ bioY protein S100757_01155 ENOG4106YBV Methyl-accepting chemotaxis S100757_01159 ENOG4105XVF Competence transcription factor S100757_01160 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S100757_01161 ENOG4105X3H Excalibur domain protein S100757_01162 ENOG4105E1V na solute symporter S100757_01163 ENOG4106CAD Protein of unknown function (DUF3311) S100757_01164 ENOG41060YP S100757_01167 ENOG4107SCK Monooxygenase S100757_01168 ENOG4108INS Transcriptional regulator S100757_01173 ENOG4105TRI Hydrolase S100757_01176 ENOG4108KK1 membrane protein AbrB duplication S100757_01177 ENOG4106K7D Major facilitator family transporter S100757_01178 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) S100757_01181 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation S100757_01183 ENOG4105EYH Exonuclease S100757_01193 ENOG4105ERH Fumarylacetoacetate hydrolase S100757_01195 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S100757_01197 ENOG4105CAQ asparagine synthetase S100757_01200 ENOG4105UQX Mate efflux family protein S100757_01201 ENOG4106HBX Transcriptional Regulator AraC Family S100757_01202 ENOG4105ETE Transcriptional regulator (LacI family S100757_01203 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S100757_01204 ENOG4105SF0 DinB family S100757_01205 ENOG4108ZUB Lysine exporter protein (Lyse ygga) S100757_01206 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S100757_01207 ENOG4105MYW Pentapeptide repeat protein S100757_01208 ENOG4107S9D Alpha beta hydrolase S100757_01209 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) S100757_01210 ENOG4107RIQ Sulfate adenylate transferase S100757_01211 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) S100757_01212 ENOG4108N5B 2-phosphosulfolactate phosphatase S100757_01213 ENOG41061P3 phosphosulfolactate synthase S100757_01215 ENOG4105DIA mandelate racemase muconate lactonizing S100757_01216 ENOG4107RCC Major Facilitator Superfamily S100757_01217 ENOG4108SZE gCN5-related N-acetyltransferase S100757_01218 ENOG4105MA6 gCN5-related N-acetyltransferase S100757_01220 ENOG4108VPT UPF0234 protein S100757_01221 ENOG4105QNR S1 RNA binding domain protein S100757_01225 ENOG4105K7K Transcriptional regulator S100757_01227 ENOG410751J S100757_01228 ENOG4105D4Y metalloprotease S100757_01229 ENOG4105EPR degv family S100757_01230 ENOG4107AYK membrAne S100757_01232 ENOG41073B9 S100757_01234 ENOG4108KP7 hydrolase S100757_01235 ENOG4108MXZ Esterase S100757_01236 ENOG4105VG1 fes assembly suf system protein S100757_01238 ENOG4105IQ5 FAD linked oxidase domain protein S100757_01241 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase S100757_01244 ENOG4105C8Y Acetylornithine aminotransferase S100757_01245 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S100757_01247 ENOG4105DBV ornithine carbamoyltransferase S100757_01252 ENOG4107RMD Basic membrane lipoprotein S100757_01255 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) S100757_01256 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) S100757_01258 ENOG4105C3U ABC transporter S100757_01259 ENOG4108JQ7 (ABC) transporter S100757_01262 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100757_01264 ENOG4105C31 Tryptophanyl-tRNA synthetase S100757_01265 ENOG4108J59 Extracellular solute-binding protein, family 5 S100757_01266 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S100757_01267 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100757_01269 ENOG4108JQ7 (ABC) transporter S100757_01272 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) S100757_01273 ENOG4108ZCF integral membrane protein S100757_01274 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis S100757_01276 ENOG4105DPN Oligoendopeptidase f S100757_01278 ENOG4105T58 Dithiol-disulfide isomerase S100757_01279 ENOG4108Z18 K06886 hemoglobin S100757_01280 ENOG4105E4C Lytic transglycosylase catalytic S100757_01281 ENOG4105MIX Adenylate cyclase S100757_01284 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) S100757_01285 ENOG4105EMS pseudouridine synthase S100757_01288 ENOG4105ETU transcriptional activator (TenA S100757_01289 ENOG4108VEU Thiamine monophosphate synthase S100757_01292 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) S100757_01293 ENOG4105D06 uba thif-type nad fad binding protein S100757_01294 ENOG4105DWF phosphomethylpyrimidine kinase S100757_01295 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH S100757_01296 ENOG4107A88 S100757_01306 ENOG4105ENA helicase S100757_01309 ENOG4108ZMI UPF0477 protein S100757_01311 ENOG4105C28 cystathionine S100757_01312 ENOG4105C28 cystathionine S100757_01313 ENOG4105D9U N-acetyltransferase S100757_01314 ENOG4105JHY Membrane S100757_01318 ENOG410635T phage-like element pbsx protein S100757_01327 ENOG4105DQ6 Transposase S100757_01328 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) S100757_01338 ENOG410780I phosphoprotein phosphatase activity S100757_01339 ENOG4106BHF S100757_01340 ENOG4106ANW SMI1_KNR4 S100757_01358 ENOG4105DM4 PTS System S100757_01359 ENOG4105DG6 mannose-6-phosphate isomerase S100757_01360 ENOG4105G7B Protein of unknown function (DUF2992) S100757_01361 ENOG4105VMI -acetyltransferase S100757_01363 ENOG4108Z66 YbaK ebsC protein S100757_01366 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) S100757_01368 ENOG4108ZJ4 polysaccharide deacetylase S100757_01369 ENOG4107CUJ Protein of unknown function (DUF2690) S100757_01374 ENOG4108IEG Formate dehydrogenase Alpha subunit S100757_01379 ENOG4106A3M Cytochrome p-450 S100757_01380 ENOG41087PP glycosyltransferase MGT family S100757_01382 ENOG4105EXQ uroporphyrinogen iii synthase hem4 S100757_01383 ENOG4105C4B ABC transporter, permease S100757_01384 ENOG4108IXI (ABC) transporter S100757_01386 ENOG4105Q95 Cupin 2, conserved barrel domain protein S100757_01389 ENOG4105D2H Uronic isomerase S100757_01390 ENOG4105CT4 transporter S100757_01391 ENOG4105DG4 malate L-lactate dehydrogenase S100757_01392 ENOG4105CPQ Dehydrogenase S100757_01393 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) S100757_01394 ENOG4105DMW Dehydrogenase reductase S100757_01395 ENOG4108I5G Major Facilitator superfamily S100757_01396 ENOG4107KJX Transcriptional regulator S100757_01397 ENOG4107QZW Altronate oxidoreductase S100757_01398 ENOG4105CTX dehydratase S100757_01399 ENOG4107TSN permease S100757_01401 ENOG4105JD4 ATPase yjob S100757_01404 ENOG41068K0 YCII-related domain S100757_01405 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S100757_01406 ENOG4105KWG Pfam:DUF1696 S100757_01407 ENOG4105K7W phage-related replication protein S100757_01408 ENOG4105WEF catalase S100757_01409 ENOG410635T phage-like element pbsx protein S100757_01419 ENOG4108TFU terminase (Small subunit) S100757_01420 ENOG4105IG6 Phage terminase, large subunit S100757_01421 ENOG4108MDF Phage Portal Protein S100757_01426 ENOG41060SN S100757_01428 ENOG4105PQS phage protein S100757_01429 ENOG4105FR7 XkdM protein, phage-like element PBSX S100757_01430 ENOG4105MTC XkdN-like protein S100757_01431 ENOG4108FKH Transglycosylase SLT domain S100757_01431 ENOG4108FKH Transglycosylase SLT domain S100757_01431 ENOG4108FKH Transglycosylase SLT domain S100757_01432 ENOG4108WZM domain protein S100757_01433 ENOG4105X7F S100757_01435 ENOG4105MFU Protein of unknown function (DUF2634) S100757_01436 ENOG41066EA baseplate J family protein S100757_01437 ENOG410906S phage-like element pbsx protein xkdt S100757_01439 ENOG41068G1 S100757_01445 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S100757_01448 ENOG4105CJ3 phosphate transporter S100757_01449 ENOG4107GRR phosphate transport regulator S100757_01450 ENOG4107R7I amino acid S100757_01452 ENOG4105EDW glycosyl transferase, family 39 S100757_01453 ENOG4105CKK Glycosyl transferase, family 2 S100757_01455 ENOG4105C0H protease S100757_01457 ENOG4108ME1 Peptidase M55 D-aminopeptidase S100757_01458 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S100757_01459 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100757_01460 ENOG4105C3U ABC transporter S100757_01463 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A S100757_01464 ENOG4105DTQ mandelate racemase muconate lactonizing S100757_01465 ENOG4107SN7 NLP P60 protein S100757_01466 ENOG4108JQ7 (ABC) transporter S100757_01467 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) S100757_01468 ENOG4107TUM Amidinotransferase S100757_01469 ENOG4108S4H thioesterase Superfamily protein S100757_01470 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) S100757_01474 ENOG4108428 Inherit from COG: -acetyltransferase S100757_01476 ENOG41080TC multidrug resistance protein S100757_01477 ENOG4105CIY formyltetrahydrofolate deformylase S100757_01478 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S100757_01481 ENOG4105K56 Transcriptional regulator S100757_01482 ENOG4108ZHJ Organic hydroperoxide resistance protein S100757_01483 ENOG4107Y2X deaminase S100757_01484 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) S100757_01485 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S100757_01487 ENOG4108W7F transporter, permease S100757_01488 ENOG4108JJB ABC transporter S100757_01489 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein S100757_01490 ENOG4108X43 YKOF domain protein S100757_01491 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S100757_01492 ENOG41062D9 Histidine kinase S100757_01494 ENOG4106849 propeptide, pepSY amd peptidase M4 S100757_01497 ENOG4105CJW magnesium transporter S100757_01498 ENOG4105V75 Transcriptional regulator S100757_01507 ENOG4105DQE DNA ligase S100757_01508 ENOG4105FDF Could be involved in DNA repair (By similarity) S100757_01509 ENOG4105BZU Histidine kinase S100757_01510 ENOG4107T5V SNARE associated Golgi S100757_01511 ENOG4107TS3 membrane protein, TerC S100757_01512 ENOG4108WZW RNA polymerase sigma S100757_01514 ENOG410681C small acid-soluble spore protein S100757_01516 ENOG4105D0M Protease HtpX homolog S100757_01520 ENOG4108TGC Acyltransferase S100757_01521 ENOG4105BZU Histidine kinase S100757_01522 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S100757_01524 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) S100757_01525 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) S100757_01526 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S100757_01528 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit S100757_01529 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) S100757_01530 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) S100757_01531 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) S100757_01535 ENOG4105BZU Histidine kinase S100757_01536 ENOG41090MY MarR family Transcriptional regulator S100757_01537 ENOG4105ER2 Ompa motb domain protein S100757_01538 ENOG4105E14 MotA TolQ exbB proton channel S100757_01540 ENOG4108K88 Membrane S100757_01541 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) S100757_01542 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase S100757_01543 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) S100757_01544 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) S100757_01546 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr S100757_01547 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S100757_01555 ENOG4107RRE RNA-directed DNA polymerase S100757_01560 ENOG4105F0V Cell wall hydrolase S100757_01563 ENOG4105C59 p-type ATPase S100757_01565 ENOG4105DC7 peptidase M24 S100757_01568 ENOG4105CID antiterminator S100757_01570 ENOG4105KRI phosphocarrier protein (HPr S100757_01571 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) S100757_01573 ENOG4105F6S Spore photoproduct lyase S100757_01575 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer S100757_01576 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase S100757_01577 ENOG4105K4I Scp-like extracellular S100757_01579 ENOG4105BZU Histidine kinase S100757_01580 ENOG4105CHM Aminotransferase S100757_01582 ENOG4107R88 Chemotaxis protein (CheV) S100757_01583 ENOG4105UIN S100757_01585 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein S100757_01587 ENOG4105K6S Short-chain dehydrogenase reductase Sdr S100757_01588 ENOG4105EPM Diguanylate phosphodiesterase S100757_01589 ENOG4107IN1 Protein of unknown function (DUF1797) S100757_01590 ENOG4108XRC Protein of unknown function (DUF458) S100757_01596 ENOG4105NQC Flavodoxin S100757_01598 ENOG4105CH2 amidohydrolase S100757_01600 ENOG4105D8X mechanosensitive ion channel S100757_01601 ENOG4105D3R alkyl hydroperoxide reductase S100757_01602 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S100757_01605 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) S100757_01606 ENOG4105D06 uba thif-type nad fad binding protein S100757_01607 ENOG4105CVM Molybdenum cofactor synthesis domain protein S100757_01608 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein S100757_01609 ENOG4108ZAF Molybdopterin S100757_01610 ENOG41067WU Molybdopterin converting factor (Subunit 1) S100757_01611 ENOG4105BZ1 (ABC) transporter S100757_01612 ENOG4105BZ1 (ABC) transporter S100757_01614 ENOG4107X8C Efflux transporter RND family MFP subunit S100757_01615 ENOG4105C19 ABC transporter S100757_01616 ENOG4107RBB ABC transporter, permease S100757_01617 ENOG4105E98 transcriptional regulator DeoR family S100757_01618 ENOG4105DE4 1-phosphofructokinase S100757_01619 ENOG4105DM4 PTS System S100757_01620 ENOG4105C3F Signal peptidase i S100757_01622 ENOG4105C5H ABC transporter S100757_01623 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) S100757_01628 ENOG4105BZU Histidine kinase S100757_01630 ENOG4107ZYR domain protein S100757_01632 ENOG4105CN5 Metallo-Beta-Lactamase S100757_01634 ENOG4108X4Q Hydrolase S100757_01635 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S100757_01640 ENOG4105CPP Dehydrogenase, E1 component S100757_01641 ENOG4105C7S Dehydrogenase S100757_01642 ENOG4107QN2 dihydrolipoyl dehydrogenase S100757_01645 ENOG4105CXN decarboxylase S100757_01646 ENOG4105WBI UPF0223 protein S100757_01649 ENOG4105ECY inositol monophosphatase S100757_01651 ENOG4105JQZ Methyltransferase S100757_01659 ENOG4105CI3 gtp-binding protein typa S100757_01660 ENOG4105QA2 S100757_01663 ENOG4108IAB Phoh family S100757_01665 ENOG4105CSV Glutaminase S100757_01666 ENOG4105ZPI UPF0358 protein S100757_01667 ENOG4105CNI cell division protein FtsW S100757_01668 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) S100757_01670 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) S100757_01672 ENOG4105BZ9 Cytochrome C oxidase, subunit I S100757_01673 ENOG4105CCU oxidase (Subunit III) S100757_01674 ENOG41064X9 cytochrome C oxidase subunit IV S100757_01677 ENOG41080XQ Signal transduction protein with cbs domains S100757_01678 ENOG4106UY4 Inherit from COG: Scp-like extracellular S100757_01682 ENOG4105WUC UPF0298 protein S100757_01683 ENOG4106H78 methyltransferase S100757_01684 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) S100757_01685 ENOG4105H20 Sporulation integral membrane protein YlbJ S100757_01686 ENOG4105D78 K07001 NTE family protein S100757_01687 ENOG41063PX domain protein S100757_01688 ENOG4105CDE UPF0348 protein S100757_01690 ENOG4105KNH Nucleic acid-binding protein S100757_01691 ENOG41067VY 50S ribosomal protein L32 S100757_01696 ENOG4108V6E Cell division protein mraZ S100757_01697 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) S100757_01699 ENOG4105CJN penicillin-binding protein S100757_01700 ENOG4105CJN penicillin-binding protein S100757_01701 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) S100757_01702 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) S100757_01703 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) S100757_01704 ENOG4105CNI cell division protein FtsW S100757_01705 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) S100757_01706 ENOG4105D4A Cell wall formation (By similarity) S100757_01707 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) S100757_01708 ENOG4108R2U division initiation protein S100757_01710 ENOG4105K67 small basic protein S100757_01711 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) S100757_01712 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) S100757_01715 ENOG4105FFI sigma-e processing peptidase spoiiga S100757_01716 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100757_01718 ENOG4105DKW ABC transporter S100757_01721 ENOG4105WR5 sporulation protein, YlmC YmxH family S100757_01722 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase S100757_01723 ENOG4105DFA alanine racemase domain protein S100757_01724 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) S100757_01725 ENOG41067XK integral membrane protein S100757_01726 ENOG4105DBK s4 domain protein S100757_01728 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) S100757_01730 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) S100757_01731 ENOG4105C34 Pseudouridine synthase S100757_01732 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) S100757_01734 ENOG4105CXT aspartate transcarbamylase S100757_01736 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S100757_01737 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain S100757_01738 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) S100757_01739 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) S100757_01740 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) S100757_01741 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) S100757_01742 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) S100757_01744 ENOG4107S4M Sulfate adenylate transferase S100757_01745 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) S100757_01746 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S100757_01747 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein S100757_01748 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein S100757_01749 ENOG4105F23 Fibronectin-binding protein S100757_01751 ENOG4105DSJ YicC domain protein S100757_01752 ENOG4105KC4 UPF0296 protein S100757_01753 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) S100757_01755 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase S100757_01756 ENOG4105C25 Primosomal protein n' S100757_01757 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S100757_01758 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) S100757_01759 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B S100757_01760 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs S100757_01761 ENOG4108ZF3 Phosphatase S100757_01762 ENOG4105D9P serine threonine protein kinase S100757_01763 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) S100757_01764 ENOG4105DJV ribulose-phosphate 3-epimerase S100757_01765 ENOG4105FJ0 thiamine S100757_01766 ENOG4105VB9 50S ribosomal protein l28 S100757_01767 ENOG4108ZAA Alkaline-shock protein S100757_01768 ENOG4105DP4 dak2 domain fusion protein ylov S100757_01770 ENOG4105EJQ L-serine dehydratase S100757_01771 ENOG4105CB5 ATP-dependent DNA helicase recG S100757_01772 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) S100757_01774 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase S100757_01775 ENOG4105CHR reductase S100757_01776 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) S100757_01777 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) S100757_01778 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) S100757_01779 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) S100757_01781 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) S100757_01783 ENOG4105K5M 30s ribosomal protein S16 S100757_01784 ENOG4108BW8 UPF0109 protein S100757_01786 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) S100757_01787 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) S100757_01788 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) S100757_01789 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) S100757_01790 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S100757_01792 ENOG4105VM1 flagellar S100757_01793 ENOG4105CMV Succinyl-CoA synthetase subunit beta S100757_01794 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha S100757_01795 ENOG4105C79 DNA protecting protein DprA S100757_01796 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) S100757_01797 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) S100757_01798 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S100757_01799 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) S100757_01800 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) S100757_01802 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) S100757_01803 ENOG4108ZC9 flagellar basal-body rod protein flgc S100757_01804 ENOG4105VQ0 flagellar hook-basal body complex protein fliE S100757_01805 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) S100757_01806 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S100757_01809 ENOG4106YF4 Flagellar biosynthesis chaperone S100757_01811 ENOG410696Y Flagellar hook-length control protein S100757_01812 ENOG410822I Flagellar hook capping protein S100757_01813 ENOG4108JQA flagellar S100757_01815 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S100757_01816 ENOG4105DD5 Flagellar motor switch protein S100757_01817 ENOG4107YTP response regulator receiver protein S100757_01819 ENOG4105CN7 Flagellar biosynthetic protein FliP S100757_01820 ENOG4105VS8 Flagellar biosynthetic protein fliq S100757_01821 ENOG4105D19 Role in flagellar biosynthesis (By similarity) S100757_01822 ENOG4105D00 flagellar biosynthetic protein flhB S100757_01823 ENOG4105D7B Flagellar biosynthesis protein flha S100757_01824 ENOG4105FZW flagellar biosynthesis regulator FlhF S100757_01826 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) S100757_01827 ENOG4105CBS Chea signal transduction histidine kinase S100757_01828 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis S100757_01831 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100757_01833 ENOG4105CE9 30S ribosomal protein S2 S100757_01834 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) S100757_01836 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) S100757_01837 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) S100757_01838 ENOG4105KNE Phosphatidate cytidylyltransferase S100757_01840 ENOG4105DZP Membrane-associated zinc metalloprotease S100757_01841 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) S100757_01842 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) S100757_01843 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) S100757_01844 ENOG4105CHV Transcription elongation factor NusA S100757_01845 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination S100757_01846 ENOG4105VHM ribosomal protein S100757_01847 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) S100757_01848 ENOG4105W7A Protein of unknown function (DUF503) S100757_01849 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) S100757_01850 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) S100757_01851 ENOG4105DTN riboflavin biosynthesis protein ribF S100757_01852 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) S100757_01853 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) S100757_01855 ENOG4105C1V Peptidase, M16 S100757_01857 ENOG4105E35 Dipicolinate synthase subunit A S100757_01858 ENOG4108S0H Dipicolinic acid synthetase, b subunit S100757_01859 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) S100757_01861 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) S100757_01863 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit S100757_01865 ENOG4105CNU cell division protein FtsK S100757_01866 ENOG4105FDP GntR family transcriptional regulator S100757_01870 ENOG4108RKS Short-chain dehydrogenase reductase Sdr S100757_01871 ENOG4105XZV Protein of unknown function (DUF3243) S100757_01874 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase S100757_01875 ENOG4105CEV competence damage-inducible protein S100757_01877 ENOG4108A04 Beta-lactamase S100757_01878 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) S100757_01879 ENOG4105D48 metallophosphoesterase S100757_01880 ENOG4105MCT stage V sporulation protein S S100757_01882 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S100757_01883 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S100757_01886 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) S100757_01887 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) S100757_01902 ENOG4105IIP Membrane S100757_01903 ENOG4105W1N transcriptional regulator S100757_01906 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S100757_01907 ENOG4105K7W phage-related replication protein S100757_01908 ENOG4108X3M OsmC Ohr family protein S100757_01909 ENOG410814C multidrug resistance protein S100757_01913 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) S100757_01914 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) S100757_01917 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) S100757_01918 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100757_01919 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100757_01920 ENOG4105U6W MutT NUDIX family protein S100757_01921 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S100757_01922 ENOG4106F1P AAA ATPase, central domain protein S100757_01923 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) S100757_01924 ENOG4105CXI aluminum resistance protein S100757_01925 ENOG4105KV4 Transcriptional regulator S100757_01926 ENOG4105C5F glutamine synthetase S100757_01927 ENOG41079P0 S100757_01931 ENOG4107AUC S100757_01937 ENOG4107NTZ S100757_01941 ENOG410907G S100757_01942 ENOG4105CT4 transporter S100757_01943 ENOG4105DSG hydrolase family 43 S100757_01944 ENOG4105E2R ROK family S100757_01945 ENOG4105C93 Xylose Isomerase S100757_01946 ENOG4105CMG Carbohydrate kinase S100757_01947 ENOG4107Y9E nuclease S100757_01948 ENOG4105C54 Major Facilitator superfamily S100757_01949 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S100757_01951 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) S100757_01967 ENOG4108NHD germination protein S100757_01970 ENOG4105FVX S100757_01973 ENOG4105K7W phage-related replication protein S100757_01975 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) S100757_01976 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) S100757_01978 ENOG4108SVB resolvase S100757_01979 ENOG4105VPS UPF0291 protein S100757_01980 ENOG4105CV1 Transketolase (EC 2.2.1.1) S100757_01984 ENOG4107QIV Cytochrome c biogenesis protein S100757_01989 ENOG4107DZX Small, acid-soluble spore protein P S100757_01991 ENOG4108I0Z Aconitate hydratase S100757_01992 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S100757_01995 ENOG41067CD Small, acid-soluble spore protein Tlp S100757_01997 ENOG4105MI2 S100757_01998 ENOG4105W8X HesB YadR YfhF-family protein S100757_01999 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) S100757_02000 ENOG4105K4P CoA-binding domain protein S100757_02001 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S100757_02006 ENOG4107QWR cellulase (EC 3.2.1.4) S100757_02008 ENOG4108MYR Secreted protein S100757_02009 ENOG4107SYN Glycosyl hydrolases family 43 S100757_02010 ENOG4107SYN Glycosyl hydrolases family 43 S100757_02012 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S100757_02013 ENOG4107T5V SNARE associated Golgi S100757_02015 ENOG4107QX3 carboxylase S100757_02016 ENOG4105E39 Enoyl-CoA hydratase S100757_02017 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase S100757_02018 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit S100757_02019 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S100757_02020 ENOG4105CEY Amp-dependent synthetase and ligase S100757_02021 ENOG4105C1G acyl-Coa dehydrogenase S100757_02022 ENOG4105F32 YngK protein S100757_02023 ENOG4106U2H Protein of unknown function (DUF1360) S100757_02025 ENOG4105CEY Amp-dependent synthetase and ligase S100757_02026 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family S100757_02027 ENOG4108N2V aldose 1-epimerase S100757_02028 ENOG4107QJQ Mate efflux family protein S100757_02033 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S100757_02034 ENOG4105SKE transcriptional Regulator LysR family S100757_02035 ENOG4105CB2 alcohol dehydrogenase S100757_02036 ENOG4105BZ8 glutamate synthase S100757_02037 ENOG4105CBC glutamate synthase S100757_02038 ENOG4105C5Q Transcriptional regulator S100757_02039 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S100757_02040 ENOG4105II7 pyrroline-5-carboxylate reductase S100757_02044 ENOG4108UB7 S100757_02045 ENOG41068WN S100757_02046 ENOG4105IE8 Alpha-ketoglutarate permease S100757_02047 ENOG4107U6E carbohydrate kinase FGGY S100757_02048 ENOG4108M3J Dehydrogenase S100757_02049 ENOG4108J2R molybdopterin oxidoreductase S100757_02051 ENOG4107QNK )-transporter S100757_02052 ENOG4105CIB oxidoreductase Domain protein S100757_02053 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) S100757_02054 ENOG4105ETE Transcriptional regulator (LacI family S100757_02058 ENOG4105EC8 Methyl-accepting chemotaxis S100757_02060 ENOG4108YQE rare lipoprotein a S100757_02061 ENOG4108YQE rare lipoprotein a S100757_02062 ENOG4105XPP Protein of unknown function (DUF1275) S100757_02063 ENOG4108NR7 pectate lyase S100757_02064 ENOG4108RAV Conserved protein S100757_02067 ENOG4105F0F Oxalate decarboxylase S100757_02071 ENOG41073R8 VanW family S100757_02073 ENOG4105VMP Transcriptional regulator S100757_02074 ENOG4105NX3 Membrane S100757_02076 ENOG4108Q5Y Membrane S100757_02078 ENOG4108V4B ThiJ pfpI S100757_02079 ENOG4108J4B Beta-lactamase S100757_02082 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S100757_02083 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S100757_02084 ENOG4107T94 Endo-14-beta-xylanase S100757_02085 ENOG4105YB8 TM2 domain containing protein S100757_02098 ENOG4107NTZ S100757_02108 ENOG4105D9U N-acetyltransferase S100757_02110 ENOG4105D06 uba thif-type nad fad binding protein S100757_02111 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) S100757_02113 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S100757_02117 ENOG4105UA4 acetyltransferase S100757_02118 ENOG4105UA4 acetyltransferase S100757_02121 ENOG4106ANW SMI1_KNR4 S100757_02122 ENOG4106BHF S100757_02125 ENOG4108Z7R Chaperone CsaA S100757_02126 ENOG4105FTV AraC Family Transcriptional Regulator S100757_02127 ENOG4108HJF gCN5-related N-acetyltransferase S100757_02129 ENOG4108W8B Beta-lactamase domain protein S100757_02131 ENOG4105D29 Helix-turn-helix type 11 domain protein S100757_02133 ENOG4105KTU Transcriptional regulator, arsr family S100757_02135 ENOG4108SJC Membrane S100757_02139 ENOG4105ECK Fatty Acid Desaturase S100757_02140 ENOG4108ZGX Histidine kinase S100757_02141 ENOG4108S01 response regulator S100757_02143 ENOG41069ER domain protein S100757_02144 ENOG4105C9U ATP-dependent DNA helicase RecQ S100757_02145 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) S100757_02146 ENOG4105SCY DNAK suppressor S100757_02154 ENOG4105C26 Dehydrogenase S100757_02155 ENOG4105EWU Squalene--hopene cyclase S100757_02156 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S100757_02157 ENOG4105C8J )-transporter S100757_02158 ENOG4105C09 Bile acid S100757_02159 ENOG4105C7S Dehydrogenase S100757_02161 ENOG4107T89 von Willebrand factor, type A S100757_02162 ENOG4105GMT ATPase associated with various cellular activities aaa_5 S100757_02164 ENOG4105K4H Nlp p60 protein S100757_02165 ENOG41087PP glycosyltransferase MGT family S100757_02168 ENOG4107QMU Mate efflux family protein S100757_02169 ENOG4106SCS STAS domain S100757_02173 ENOG4105FR1 rard protein S100757_02176 ENOG4105C6Z Gluconate S100757_02177 ENOG4105C6Z Gluconate S100757_02178 ENOG41090U3 tautomerase S100757_02181 ENOG4105FBA Phospholipase Carboxylesterase S100757_02184 ENOG4105E1V na solute symporter S100757_02188 ENOG4108VXD carboxy-peptidase S100757_02189 ENOG4105D3A purine nucleoside phosphorylase DeoD-type S100757_02191 ENOG4106Z5R S100757_02192 ENOG410841Q phosphoesterase PA-phosphatase related protein S100757_02198 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein S100757_02199 ENOG4108TSC N-acetyltransferase S100757_02200 ENOG4107S4Y M20 DapE family protein YgeY S100757_02203 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S100757_02211 ENOG4107T32 3-phytase (EC 3.1.3.8) S100757_02212 ENOG4105C5E polysaccharide biosynthesis protein S100757_02213 ENOG4105E0X reductase S100757_02214 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) S100757_02218 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) S100757_02219 ENOG41090WU lipolytic protein G-D-S-L family S100757_02220 ENOG4108KF3 Electron transport protein SCO1 SenC S100757_02222 ENOG4105C7B Threonine dehydratase S100757_02224 ENOG4108UT2 hemolysin iii S100757_02226 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) S100757_02229 ENOG4107YX5 Pfam:DUF548 S100757_02230 ENOG4108Y6J UPF0403 protein S100757_02231 ENOG4105C01 Dihydroxy-acid dehydratase S100757_02234 ENOG4108V06 Glutathione peroxidase S100757_02235 ENOG4105CVG Homoserine O-transsuccinylase S100757_02243 ENOG41081VK Ribonuclease S100757_02248 ENOG410890F Dynamin family S100757_02251 ENOG41065KQ synthase S100757_02252 ENOG4105C2W permease S100757_02253 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) S100757_02254 ENOG4105CTD carboxy-peptidase S100757_02255 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) S100757_02256 ENOG4108UHU Aldolase S100757_02257 ENOG4105D7K pfkb domain protein S100757_02258 ENOG4108M60 Transcriptional regulator S100757_02260 ENOG4105CHR reductase S100757_02261 ENOG4105DVT helicase S100757_02263 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) S100757_02265 ENOG4108UKS UPF0398 protein S100757_02266 ENOG4107X2U Inherit from COG: Exonuclease-like protein S100757_02267 ENOG4108I5C dEAD DEAH box helicase S100757_02277 ENOG4105BZ4 penicillin-binding protein S100757_02279 ENOG4105CSM endonuclease III S100757_02281 ENOG4105C5S asparaginyl-tRNA synthetase S100757_02282 ENOG4105CHM Aminotransferase S100757_02284 ENOG4105YAC S100757_02285 ENOG4105DVT helicase S100757_02286 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) S100757_02287 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) S100757_02288 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) S100757_02289 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase S100757_02290 ENOG4105DJ0 Poly(A) Polymerase S100757_02291 ENOG4105CPK Glycosyl transferase (Group 1 S100757_02292 ENOG4105FJR Lmbe family S100757_02293 ENOG4108Z5K methylglyoxal synthase S100757_02294 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) S100757_02295 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase S100757_02296 ENOG4108JYZ YitT family S100757_02300 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) S100757_02304 ENOG41068YB TPR repeat-containing protein S100757_02305 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase S100757_02309 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) S100757_02310 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase S100757_02312 ENOG4108I0Q anthranilate phosphoribosyltransferase S100757_02313 ENOG4105CRQ synthase (Component I) S100757_02314 ENOG4105KHN chorismate mutase S100757_02315 ENOG4105D49 3-dehydroquinate synthase S100757_02316 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase S100757_02317 ENOG4105BZU Histidine kinase S100757_02318 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) S100757_02319 ENOG4105EAH synthase S100757_02320 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) S100757_02321 ENOG4105XXQ heptaprenyl diphosphate synthase component I S100757_02323 ENOG4105EUJ GTP cyclohydrolase i S100757_02324 ENOG4105K70 DNA-binding protein S100757_02325 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) S100757_02328 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase S100757_02329 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) S100757_02330 ENOG41065D1 S100757_02331 ENOG4105S2F S100757_02334 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) S100757_02335 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) S100757_02336 ENOG4105CAT Cytidine monophosphate kinase S100757_02339 ENOG4105MSI germination protein ypeb S100757_02341 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) S100757_02342 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase S100757_02345 ENOG4107RGJ metallophosphoesterase S100757_02348 ENOG4105I7S Abortive infection protein S100757_02349 ENOG4105C9U ATP-dependent DNA helicase RecQ S100757_02350 ENOG4105T7X S100757_02352 ENOG4108SAX Membrane S100757_02353 ENOG4108JQ1 Dehydrogenase S100757_02354 ENOG4105FF2 Type I DHQase S100757_02357 ENOG4105BZU Histidine kinase S100757_02358 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S100757_02359 ENOG4105CRE cytochrome C S100757_02360 ENOG4107TWT Cytochrome c biogenesis protein S100757_02362 ENOG4105FE9 pseudouridine synthase S100757_02364 ENOG4108JIC nucleoside recognition domain protein S100757_02365 ENOG4105DZ1 carboxypeptidase S100757_02367 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) S100757_02368 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) S100757_02371 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) S100757_02372 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) S100757_02373 ENOG4108R6K riboflavin synthase, subunit alpha S100757_02374 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) S100757_02376 ENOG4105C3F Signal peptidase i S100757_02377 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) S100757_02379 ENOG4107ZE5 PPIases accelerate the folding of proteins S100757_02386 ENOG4107ZE5 PPIases accelerate the folding of proteins S100757_02387 ENOG4105PTM secreted protein S100757_02388 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) S100757_02390 ENOG4105G6R Stage v sporulation protein ae S100757_02392 ENOG4105CZ3 stage V sporulation protein ad S100757_02393 ENOG41090VF Stage v sporulation protein ac S100757_02396 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100757_02397 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) S100757_02398 ENOG41082AN stage II sporulation protein S100757_02399 ENOG4105DZ1 carboxypeptidase S100757_02400 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) S100757_02401 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) S100757_02402 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S100757_02404 ENOG4105I3K Ferric uptake regulator, Fur family S100757_02405 ENOG4105MZ9 stage II sporulation protein m S100757_02408 ENOG4105DFD Na H antiporter S100757_02409 ENOG4108IJ0 Aspartate ammonia-lyase S100757_02410 ENOG4105HDK L-asparaginase S100757_02411 ENOG4108IMY Transcriptional regulator S100757_02413 ENOG4108YZ4 nudix hydrolase S100757_02415 ENOG4105CPC Aldo Keto reductase S100757_02419 ENOG4106HZJ S100757_02420 ENOG4105RHY Pfam:UPF0157 S100757_02421 ENOG4105KAC Antibiotic biosynthesis monooxygenase S100757_02422 ENOG4108XET gCN5-related N-acetyltransferase S100757_02424 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S100757_02426 ENOG4105E5W Transporter S100757_02428 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase S100757_02431 ENOG4108IXY short-chain dehydrogenase reductase S100757_02432 ENOG41069FQ Metallo-beta-lactamase superfamily S100757_02433 ENOG4105II7 pyrroline-5-carboxylate reductase S100757_02435 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S100757_02437 ENOG410861F 50S ribosomal protein L33 S100757_02438 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) S100757_02439 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase S100757_02440 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) S100757_02441 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S100757_02443 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) S100757_02444 ENOG4108NA0 Uncharacterized conserved protein (COG2071) S100757_02445 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S100757_02446 ENOG4108HNZ carboxyl transferase S100757_02447 ENOG4108ZVT methylmalonyl-coA epimerase S100757_02449 ENOG4108VZI ErfK ybiS ycfS ynhG family protein S100757_02450 ENOG4108QEG Membrane S100757_02451 ENOG4105CDA abc transporter atp-binding protein S100757_02452 ENOG4105E5Q amino acid AbC transporter S100757_02453 ENOG4108HW3 (ABC) transporter S100757_02454 ENOG4108Y6J UPF0403 protein S100757_02455 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) S100757_02458 ENOG4105C7S Dehydrogenase S100757_02459 ENOG4105CPP Dehydrogenase, E1 component S100757_02462 ENOG4105CKM Branched-chain carboxylic acid kinase S100757_02463 ENOG4107RDP Dehydrogenase S100757_02465 ENOG4108JUB Transcriptional regulator S100757_02466 ENOG4106CCJ Protein of unknown function (DUF2627) S100757_02467 ENOG4105CR4 methylisocitrate lyase S100757_02468 ENOG4105DXD 2-methylcitrate dehydratase S100757_02470 ENOG4105C1G acyl-Coa dehydrogenase S100757_02471 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase S100757_02473 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S100757_02474 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S100757_02477 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S100757_02479 ENOG4107QQR Sporulation S100757_02480 ENOG4105S1Z Stage IV sporulation protein B S100757_02481 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) S100757_02482 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) S100757_02483 ENOG4105DX0 Hemolysin A S100757_02485 ENOG4105CTB Polyprenyl synthetase S100757_02486 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S100757_02487 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S100757_02488 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) S100757_02489 ENOG4105M7K Involved in the transcription termination process (By similarity) S100757_02490 ENOG4108ZSR alkaline shock protein S100757_02491 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S100757_02495 ENOG410644B Stage III sporulation protein af S100757_02497 ENOG4105KQ4 Stage iii sporulation protein ad S100757_02498 ENOG4108CQH stage III sporulation protein AC S100757_02499 ENOG4105KR5 Stage iii sporulation protein S100757_02500 ENOG4105CD2 stage iii sporulation protein aa S100757_02502 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) S100757_02503 ENOG4105DC7 peptidase M24 S100757_02504 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) S100757_02506 ENOG4105CBJ Metal-dependent enzyme S100757_02509 ENOG4105KST dependent repressor S100757_02510 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) S100757_02511 ENOG4105WZW rhodanese family S100757_02512 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor S100757_02513 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor S100757_02514 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) S100757_02515 ENOG4105C0D helicase S100757_02518 ENOG4108IMY Transcriptional regulator S100757_02520 ENOG4105VFR signal peptidase S100757_02531 ENOG41080XP Cbs domain S100757_02533 ENOG4105C37 (CBS) domain S100757_02538 ENOG4105C5X domain protein S100757_02543 ENOG4105E0M Sulfatase S100757_02546 ENOG4107ZXI Rhomboid family S100757_02548 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase S100757_02549 ENOG4105WDJ 50S ribosomal protein L33 S100757_02553 ENOG41068DG YceG-like family S100757_02554 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S100757_02555 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S100757_02556 ENOG4105E2Z phosphate ABC transporter (Permease S100757_02557 ENOG4105C8U phosphate abc transporter S100757_02558 ENOG4105CVA phosphate S100757_02559 ENOG4107RF6 penicillin-binding protein S100757_02561 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S100757_02562 ENOG4105SXS Protein of unknown function (DUF456) S100757_02565 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) S100757_02566 ENOG41063Y9 S100757_02567 ENOG4108U5J '-nucleotidase S100757_02568 ENOG4105N80 Ferric uptake regulator, Fur family S100757_02569 ENOG4108JYZ YitT family S100757_02570 ENOG41069ZM Protein of unknown function (DUF2624) S100757_02571 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) S100757_02574 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) S100757_02575 ENOG4105EGD dinuclear metal center protein, YbgI family S100757_02578 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100757_02579 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) S100757_02580 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 S100757_02581 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) S100757_02583 ENOG4105C38 Glycyl-tRNA synthetase beta subunit S100757_02584 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit S100757_02585 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) S100757_02587 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) S100757_02588 ENOG4105KG3 cytidine deaminase S100757_02589 ENOG4107YR5 Diacylglycerol kinase S100757_02590 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) S100757_02591 ENOG4105CTJ Metal Dependent Phosphohydrolase S100757_02592 ENOG4105CTJ Metal Dependent Phosphohydrolase S100757_02594 ENOG4105C9A Phoh family S100757_02595 ENOG4105EI1 sporulation protein yqfd S100757_02596 ENOG41068P3 sporulation protein YqfC S100757_02598 ENOG4105DI5 UPF0365 protein S100757_02599 ENOG4105F7J membrane-bound serine protease S100757_02600 ENOG4105KTH gatB Yqey S100757_02603 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S100757_02604 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) S100757_02605 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) S100757_02607 ENOG4105CFG Acts as a chaperone (By similarity) S100757_02608 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ S100757_02609 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) S100757_02610 ENOG4105CSA Coproporphyrinogen iii oxidase S100757_02611 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) S100757_02613 ENOG4108ZRV stage ii sporulation protein p S100757_02614 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) S100757_02615 ENOG41082YS Binds directly to 16S ribosomal RNA S100757_02616 ENOG4105TQK DNA polymerase iii, delta' subunit S100757_02618 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 S100757_02619 ENOG4108UK2 deaminase S100757_02620 ENOG4105KQC Competence protein S100757_02622 ENOG4108D32 Methyltransferase S100757_02624 ENOG4108WF2 Metal Dependent Phosphohydrolase S100757_02625 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) S100757_02626 ENOG410812S Rna-binding protein S100757_02627 ENOG4105E2X shikimate dehydrogenase S100757_02628 ENOG4105CQW ribosome biogenesis GTPase YqeH S100757_02629 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase S100757_02632 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S100757_02633 ENOG41080BT SNARE associated Golgi S100757_02636 ENOG4105WFK nuclease S100757_02637 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100757_02638 ENOG4105C9Q fumarate hydratase class II S100757_02639 ENOG4107RSM transcriptional regulator S100757_02654 ENOG41064HX Suppressor of fused protein (SUFU) S100757_02657 ENOG4105FR7 XkdM protein, phage-like element PBSX S100757_02664 ENOG41090E6 transcriptional regulator MERR family S100757_02667 ENOG4105C37 (CBS) domain S100757_02670 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family S100757_02671 ENOG4105H3G oxidoreductase S100757_02672 ENOG4105PGM cation diffusion facilitator family transporter S100757_02675 ENOG4105KMT branched-chain amino acid S100757_02676 ENOG4108UMN azlc family S100757_02677 ENOG4108ZRZ Transcriptional regulator (AsnC family) S100757_02678 ENOG41067XF inhibitor S100757_02682 ENOG41064BW Protein of unknown function (DUF2568) S100757_02685 ENOG41075D4 Aminoglycoside 6-adenylyltransferase S100757_02686 ENOG4105EA8 2-Nitropropane dioxygenase S100757_02687 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) S100757_02690 ENOG4108MEK Metal-binding protein YodA S100757_02691 ENOG410904A RNA polymerase S100757_02692 ENOG4105CPC Aldo Keto reductase S100757_02694 ENOG4108KAM Transcriptional regulator S100757_02695 ENOG4105C7F AcnD-accessory protein PrpF S100757_02696 ENOG41083Q9 chitosanase S100757_02697 ENOG4105X5K response regulator receiver protein S100757_02698 ENOG4108VQT Alpha beta hydrolase fold protein S100757_02699 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein S100757_02700 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein S100757_02701 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase S100757_02703 ENOG4105PGS Spore coat protein S100757_02704 ENOG4105E2A Dehydrogenase S100757_02707 ENOG4105VUF Transcriptional regulator S100757_02709 ENOG4105DQ4 alcohol dehydrogenase S100757_02710 ENOG4108Z0Z intracellular protease Pfpi family S100757_02711 ENOG4108HKT sucrose-6-phosphate hydrolase S100757_02712 ENOG4105F3R pts system mannose fructose sorbose family iid S100757_02713 ENOG4105ETZ PTS System S100757_02714 ENOG4108IQ3 PTS system S100757_02715 ENOG4105YHU PTS system S100757_02716 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family S100757_02717 ENOG4105C85 amino acid S100757_02718 ENOG4105N14 lysine exporter protein LysE YggA S100757_02719 ENOG4108NGU Transcriptional regulator S100757_02720 ENOG4105JVQ RNA Polymerase S100757_02721 ENOG4108P49 AntiSigma factor S100757_02722 ENOG4105EXC Acyl-transferase S100757_02723 ENOG4105WDR S100757_02724 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S100757_02725 ENOG41082JN Transcriptional regulator S100757_02729 ENOG4105TMB Formate nitrite transporter S100757_02730 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) S100757_02731 ENOG4108JB9 formate dehydrogenase S100757_02734 ENOG4105C28 cystathionine S100757_02737 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) S100757_02740 ENOG4107XRG penicillin-binding protein S100757_02741 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) S100757_02742 ENOG4105DBI uridine monophosphokinase S100757_02743 ENOG4105CFP Peptidase U32 S100757_02744 ENOG4105XYU peptidase (U32 family) S100757_02745 ENOG4108VQJ O-methyltransferase S100757_02746 ENOG4105HHA aminodeoxychorismate lyase S100757_02747 ENOG4105VPH UPF0473 protein S100757_02748 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) S100757_02749 ENOG4105VBH UPF0297 protein S100757_02750 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) S100757_02751 ENOG4105C02 permease S100757_02752 ENOG4105CDA abc transporter atp-binding protein S100757_02753 ENOG4105CT1 (ABC) transporter S100757_02754 ENOG4105EAD ABC transporter S100757_02755 ENOG4105DRP amino acid AbC transporter S100757_02757 ENOG41060CR S100757_02759 ENOG4105C7H Helicase, RecD TraA family S100757_02761 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) S100757_02762 ENOG4105C3J Cysteine desulfurase S100757_02764 ENOG4105D1H recombination factor protein RarA S100757_02765 ENOG4105CUZ uba thif-type nad fad binding protein S100757_02766 ENOG4105C9M aspartyl-trna synthetase S100757_02767 ENOG4105CUT histidyl-tRNA synthetase S100757_02769 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S100757_02771 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) S100757_02772 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) S100757_02773 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) S100757_02774 ENOG41067VP Protein of unknown function (DUF1049) S100757_02775 ENOG4105NCW Trka-c domain protein S100757_02776 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) S100757_02778 ENOG4105CKP Polysaccharide Biosynthesis Protein S100757_02779 ENOG4108QG2 Membrane S100757_02780 ENOG4105NAP S100757_02781 ENOG4105VIE preprotein translocase, subunit YajC S100757_02782 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) S100757_02783 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) S100757_02784 ENOG41061AI Protein of unknown function (DUF2905) S100757_02785 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) S100757_02786 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) S100757_02788 ENOG4105IE8 Alpha-ketoglutarate permease S100757_02789 ENOG4105CK5 oxidoreductase S100757_02794 ENOG4105BZG amino acid carrier protein S100757_02795 ENOG4105CDY transcriptional regulatory protein S100757_02797 ENOG4106678 morphogenetic protein associated with SpoVID S100757_02798 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) S100757_02799 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase S100757_02800 ENOG4108IYU L-aspartate oxidase S100757_02803 ENOG4105CQC Prephenate dehydratase S100757_02804 ENOG41090I5 UPF0735 ACT domain-containing protein S100757_02805 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control S100757_02807 ENOG4105K46 50S ribosomal protein l27 S100757_02808 ENOG4105X36 (ribosomal) protein S100757_02809 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) S100757_02812 ENOG4107QMS site-determining protein S100757_02813 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) S100757_02814 ENOG4105YHC Rod shape-determining protein MreD S100757_02815 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) S100757_02816 ENOG4105DFF Rod shape-determining protein mreb S100757_02817 ENOG4105W5Q DNA repair protein (RadC S100757_02818 ENOG4108Z03 MAF-like protein S100757_02820 ENOG4106A3R peptidase S100757_02821 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase S100757_02822 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) S100757_02824 ENOG4106AR7 Spore coat protein S100757_02825 ENOG41068KH stage VI sporulation protein D S100757_02826 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase S100757_02827 ENOG4105D52 delta-aminolevulinic acid dehydratase S100757_02829 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) S100757_02831 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) S100757_02833 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) S100757_02834 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) S100757_02835 ENOG4108IUQ atp-dependent protease S100757_02836 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) S100757_02837 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation S100757_02839 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S100757_02840 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S100757_02841 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S100757_02842 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) S100757_02843 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase S100757_02844 ENOG4108ZP8 Acetolactate synthase small subunit S100757_02845 ENOG4105C7K acetolactate synthase S100757_02847 ENOG4105I4A GCN5-related N-acetyltransferase S100757_02848 ENOG4107KM7 Heat induced stress protein YflT S100757_02850 ENOG4105M59 Phosphodiesterase, mj0936 family S100757_02851 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) S100757_02852 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) S100757_02853 ENOG4108XJQ germination protein S100757_02854 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) S100757_02855 ENOG41067TZ transcriptional regulator, MarR family S100757_02856 ENOG4105PFC Transcriptional regulator S100757_02858 ENOG4105E33 succinate dehydrogenase S100757_02860 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit S100757_02862 ENOG4105CFH Aspartokinase S100757_02863 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) S100757_02864 ENOG4105K63 Thioredoxin S100757_02865 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) S100757_02867 ENOG4105C10 Electron transfer flavoprotein S100757_02868 ENOG4105BZJ Electron transfer flavoprotein S100757_02869 ENOG41060WC Enoyl-CoA hydratase S100757_02870 ENOG4107Z3H Transcriptional regulator, TetR family S100757_02871 ENOG4105CEY Amp-dependent synthetase and ligase S100757_02873 ENOG4105C98 muts2 protein S100757_02874 ENOG4105DCG PHP domain protein S100757_02877 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S100757_02878 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) S100757_02879 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) S100757_02880 ENOG4108RWN rrna methyltransferase S100757_02881 ENOG41067MF small acid-soluble spore protein S100757_02883 ENOG4105CQB FAD linked oxidase domain protein S100757_02884 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S100757_02887 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) S100757_02888 ENOG4105DRS transport system, permease S100757_02891 ENOG4108MDK Dehydrogenase S100757_02893 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase S100757_02894 ENOG4105EF1 ribulokinase S100757_02896 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase S100757_02897 ENOG4105CN9 Peptidase m42 family protein S100757_02899 ENOG410696E Membrane S100757_02900 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) S100757_02901 ENOG4105VJV 50s ribosomal protein L35 S100757_02902 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) S100757_02904 ENOG41067MG lrgb family S100757_02906 ENOG4105DY9 regulatoR S100757_02907 ENOG4108HRK Histidine kinase S100757_02908 ENOG4105U0R haloacid dehalogenase-like hydrolase S100757_02909 ENOG4105C22 threonyL-tRNA synthetase S100757_02911 ENOG4108TDW sporulation protein YtxC S100757_02915 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) S100757_02916 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) S100757_02917 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S100757_02918 ENOG4105KVH Transcriptional regulator S100757_02919 ENOG4105KVH Transcriptional regulator S100757_02920 ENOG4105F27 Major Facilitator S100757_02921 ENOG4105CV8 reductase S100757_02922 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) S100757_02924 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) S100757_02925 ENOG4105C2M dna polymerase I S100757_02926 ENOG4105BZU Histidine kinase S100757_02927 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S100757_02928 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) S100757_02929 ENOG4108HMX isocitrate dehydrogenase (NADP) S100757_02930 ENOG4105BZN citrate synthase S100757_02932 ENOG4108REF Sporulation integral membrane protein ytvi S100757_02933 ENOG4105FS0 cytoplasmic membrane protein S100757_02934 ENOG4105CA9 Pyruvate kinase S100757_02935 ENOG4105CTQ phosphohexokinase S100757_02937 ENOG4108IEY Carboxyl transferase domain S100757_02938 ENOG4105C6K Malic enzyme S100757_02939 ENOG4105C0B DNA polymerase III (alpha subunit) S100757_02940 ENOG4105VV2 S100757_02942 ENOG4106EVM S100757_02943 ENOG4105SFS phosphoesterase RecJ domain protein S100757_02946 ENOG4105E8R UPF0173 metal-dependent hydrolase S100757_02949 ENOG4105CH7 arginosuccinase S100757_02950 ENOG4105CDH Citrulline--aspartate ligase S100757_02951 ENOG4105EPU Molybdenum cofactor synthesis domain protein S100757_02952 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) S100757_02955 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) S100757_02956 ENOG4105KBJ sporulation protein ytfj S100757_02958 ENOG4105VK3 rdd domain containing protein S100757_02959 ENOG4105D07 Signal peptide peptidase, SppA S100757_02960 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) S100757_02961 ENOG4105EFZ amidohydrolase S100757_02962 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) S100757_02969 ENOG4105U5Y Transcriptional regulator S100757_02971 ENOG4105BZU Histidine kinase S100757_02972 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) S100757_02974 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S100757_02976 ENOG4105F1V Acetoin utilization protein S100757_02977 ENOG4105W87 Cbs domain S100757_02978 ENOG4105DGU Histone deacetylase S100757_02979 ENOG4105ER2 Ompa motb domain protein S100757_02980 ENOG4107R0U MotA TolQ exbB proton channel S100757_02981 ENOG4105ETE Transcriptional regulator (LacI family S100757_02982 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase S100757_02986 ENOG4105DFU Cell wall formation (By similarity) S100757_02988 ENOG4108VDD TRNA binding domain protein S100757_02991 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ S100757_02994 ENOG4105C6K Malic enzyme S100757_02995 ENOG4105C8F Beta-lactamase domain protein S100757_02996 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) S100757_02998 ENOG4108V15 phosphotransferase enzyme family S100757_02999 ENOG4108IUM Glycogen debranching enzyme S100757_03002 ENOG4107F58 2'-5' rna ligase S100757_03003 ENOG4105C6T cysteine synthase S100757_03004 ENOG4107QSE Dipeptidase S100757_03005 ENOG4105C7N Xanthine uracil vitamin C permease S100757_03008 ENOG4105YW5 deoR family transcriptional regulator S100757_03011 ENOG4105CBX hi0933 family S100757_03012 ENOG4105C94 Transporter S100757_03014 ENOG4105MU9 integral membrane protein S100757_03015 ENOG4105DDC Oxidoreductase domain protein S100757_03017 ENOG4105F5H Glycosyl Hydrolase Family 88 S100757_03019 ENOG41075H3 AraC family transcriptional regulator S100757_03021 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component S100757_03023 ENOG4106A3M Cytochrome p-450 S100757_03024 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) S100757_03026 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S100757_03027 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S100757_03029 ENOG4105NTD Inherit from COG: Hydrolase S100757_03032 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component S100757_03033 ENOG4105I1K ABC transporter S100757_03035 ENOG41085GJ domain protein S100757_03036 ENOG4105C8T Leucyl-tRNA synthetase S100757_03038 ENOG4105BZU Histidine kinase S100757_03039 ENOG410605W Major Facilitator S100757_03040 ENOG4106UBQ S100757_03042 ENOG4105C19 ABC transporter S100757_03043 ENOG4105EWM Histidine kinase S100757_03045 ENOG4107R34 abc transporter permease protein S100757_03046 ENOG4105C19 ABC transporter S100757_03049 ENOG4105DVE abc transporter atp-binding protein S100757_03050 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family S100757_03053 ENOG4105N5T Radical SAM Protein S100757_03056 ENOG4105E8V Alpha Beta Hydrolase Fold protein S100757_03057 ENOG4108Z0R Transferase S100757_03058 ENOG4105C85 amino acid S100757_03059 ENOG4105CAQ asparagine synthetase S100757_03060 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP S100757_03061 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase S100757_03064 ENOG4105D2X ABC transporter substrate-binding protein S100757_03066 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component S100757_03069 ENOG4108RMU ferritin dps family protein S100757_03072 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) S100757_03073 ENOG4108V2W Carbonate dehydratase S100757_03078 ENOG4105CC5 ABC transporter S100757_03079 ENOG4105CC5 ABC transporter S100757_03080 ENOG4105DIK (ABC) transporter S100757_03081 ENOG4105DSE periplasmic solute binding protein S100757_03082 ENOG4105DTQ mandelate racemase muconate lactonizing S100757_03083 ENOG4105CEY Amp-dependent synthetase and ligase S100757_03084 ENOG4108IPT Naphthoate synthase S100757_03085 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) S100757_03086 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) S100757_03087 ENOG4105E4F Isochorismate synthase S100757_03091 ENOG4108IAJ Nad-dependent epimerase dehydratase S100757_03092 ENOG4107SBE Glycosyl transferase (Group 1 S100757_03095 ENOG4107SBE Glycosyl transferase (Group 1 S100757_03096 ENOG4108KS4 Spore coat protein S100757_03099 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) S100757_03101 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) S100757_03127 ENOG4105N67 Proton-coupled thiamine transporter YuaJ S100757_03128 ENOG4105VRR gCN5-related N-acetyltransferase S100757_03129 ENOG4105DZ6 Band 7 protein S100757_03131 ENOG4106DF1 S100757_03132 ENOG4108VNY MOSC domain protein S100757_03133 ENOG4108JB8 alcohol dehydrogenase S100757_03134 ENOG4105C26 Dehydrogenase S100757_03135 ENOG4105TRT Transcriptional regulator S100757_03138 ENOG4105CZN Potassium uptake protein S100757_03139 ENOG4107I77 yiaA/B two helix domain S100757_03140 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S100757_03144 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) S100757_03146 ENOG4105EE0 oxidoreductase S100757_03147 ENOG4105DKG l-rhamnose isomerase S100757_03148 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) S100757_03149 ENOG4105DET Rhamnulokinase S100757_03150 ENOG4105E98 transcriptional regulator DeoR family S100757_03152 ENOG4105C8Q Methyl-accepting chemotaxis S100757_03153 ENOG4105C8Q Methyl-accepting chemotaxis S100757_03154 ENOG4105C8Q Methyl-accepting chemotaxis S100757_03155 ENOG4105C8Q Methyl-accepting chemotaxis S100757_03158 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme S100757_03160 ENOG4105C37 (CBS) domain S100757_03163 ENOG4107PBV potassium channel S100757_03164 ENOG4107PBV potassium channel S100757_03167 ENOG4107QYV phosphohexose isomerase S100757_03169 ENOG4107QW4 alcohol dehydrogenase S100757_03170 ENOG4105WG9 Conserved Protein S100757_03172 ENOG4105CHM Aminotransferase S100757_03173 ENOG4108ZB6 transcriptional regulator AsnC family S100757_03174 ENOG4108MUZ hydrolase S100757_03176 ENOG4105C87 Aminotransferase class I and II S100757_03177 ENOG4108HGU Histidine kinase S100757_03178 ENOG4105Y38 Kinase-associated protein B S100757_03182 ENOG4105BZ4 penicillin-binding protein S100757_03183 ENOG4105KIR Thiol-disulfide oxidoreductase dcc S100757_03186 ENOG4108MRH transcriptional regulatory protein S100757_03187 ENOG4105DIH basic membrane S100757_03188 ENOG4108JQ9 ABC transporter S100757_03189 ENOG4105UIB (ABC) transporter S100757_03193 ENOG4105D65 subunit l S100757_03194 ENOG4105HC0 Na H antiporter S100757_03195 ENOG4108ZE9 Monovalent cation H antiporter subunit C S100757_03196 ENOG4108JPZ Monovalent cation H antiporter subunit D S100757_03197 ENOG4105SC1 monovalent cation H antiporter subunit E S100757_03199 ENOG4105KJM monovalent cation h antiporter subunit g S100757_03200 ENOG4105KA0 thioesterase Superfamily protein S100757_03202 ENOG4105BZU Histidine kinase S100757_03208 ENOG4105D58 Diguanylate phosphodiesterase S100757_03209 ENOG4105DAP Nicotinate phosphoribosyltransferase S100757_03214 ENOG4105C02 permease S100757_03217 ENOG410904N short-chain dehydrogenase reductase S100757_03224 ENOG4108K8K Transcriptional regulator S100757_03225 ENOG4105DCF alanine dehydrogenase S100757_03227 ENOG4105WQT MbtH domain protein S100757_03228 ENOG4105CEY Amp-dependent synthetase and ligase S100757_03229 ENOG4105WQI isochorismatase S100757_03230 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase S100757_03231 ENOG4105E4F Isochorismate synthase S100757_03232 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase S100757_03233 ENOG4105NIV Esterase S100757_03237 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) S100757_03239 ENOG41069ER domain protein S100757_03241 ENOG4105CEP NADH dehydrogenase S100757_03242 ENOG4105CAY ferredoxin--nadp reductase S100757_03246 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 S100757_03248 ENOG4108YX9 iron--sulfur cluster insertion protein erpA S100757_03251 ENOG4105ZKE UPF0349 protein S100757_03254 ENOG41083MR nifu domain-containing protein S100757_03255 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein S100757_03256 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) S100757_03257 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) S100757_03258 ENOG4105D6E homoserine dehydrogenase S100757_03260 ENOG4108W5N phosphatidylglycerophosphatase a S100757_03261 ENOG4105D4U had-superfamily hydrolase, subfamily iia S100757_03263 ENOG4105MMD transcriptional regulator S100757_03264 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) S100757_03265 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) S100757_03266 ENOG4105FAA peptidase M23 S100757_03267 ENOG4108YTE sporulation protein YunB S100757_03268 ENOG4105KZD Domain of unknown function (DUF1805) S100757_03269 ENOG4107R8B 5'-nucleotidase S100757_03271 ENOG4105I3N Conserved Protein S100757_03273 ENOG4105CD3 dihydroorotase S100757_03274 ENOG4105G9B Transcriptional regulator S100757_03277 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) S100757_03278 ENOG4105VT2 5-hydroxyisourate hydrolase S100757_03280 ENOG4107YV9 domain protein S100757_03281 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding S100757_03284 ENOG4105XRQ Xanthine dehydrogenase accessory factor S100757_03285 ENOG4105C5R Aminotransferase S100757_03287 ENOG4108K8S endonuclease I S100757_03288 ENOG4108IJ9 (ABC) transporter S100757_03289 ENOG4105FDP GntR family transcriptional regulator S100757_03290 ENOG4108KPW sugar kinase S100757_03291 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component S100757_03292 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component S100757_03293 ENOG4105XN3 extracellular solute-binding protein family 1 S100757_03294 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine S100757_03295 ENOG4105PKS Excinuclease abc c subunit domain protein S100757_03296 ENOG4107VFR oxidoreductase S100757_03299 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase S100757_03300 ENOG4105NPE arsR family transcriptional regulator S100757_03301 ENOG4105DIW FeS assembly protein SUFB S100757_03302 ENOG4108UNV SUF system FeS assembly protein, NifU family S100757_03303 ENOG4105C9B Cysteine desulfurase S100757_03304 ENOG4105JRK feS assembly protein SufD S100757_03305 ENOG4105C3K feS assembly ATPase SufC S100757_03307 ENOG4105D01 (LipO)protein S100757_03308 ENOG4108UMI ABC transporter, permease S100757_03309 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) S100757_03314 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) S100757_03315 ENOG41080E8 Transcriptional regulator, Spx MgsR family S100757_03316 ENOG4105C1G acyl-Coa dehydrogenase S100757_03317 ENOG4105CHU acetyl-coa acetyltransferase S100757_03323 ENOG41067TZ transcriptional regulator, MarR family S100757_03324 ENOG4105C0R drug resistance transporter emrb qaca subfamily S100757_03325 ENOG4105MDS 4-oxalocrotonate tautomerase S100757_03327 ENOG4105EGI Transcriptional regulator S100757_03329 ENOG4105E0A ABC, transporter S100757_03342 ENOG4105E1F short-chain dehydrogenase reductase S100757_03343 ENOG4105HUF DNA protection during starvation protein S100757_03344 ENOG4105C0H protease S100757_03346 ENOG4105F3H Histidine kinase S100757_03347 ENOG41067SE Tetr family transcriptional regulator S100757_03348 ENOG4105C9Q fumarate hydratase class II S100757_03353 ENOG4105WH1 Two component transcriptional regulator luxr family S100757_03354 ENOG4105ENE Histidine kinase S100757_03357 ENOG41087YS Phage shock protein A S100757_03360 ENOG4108WBT adenosyltransferase S100757_03361 ENOG4105E0A ABC, transporter S100757_03362 ENOG4105EHG Permease protein S100757_03363 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) S100757_03364 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S100757_03365 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein S100757_03367 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S100757_03369 ENOG4106DF4 Sigma-70, region 4 S100757_03371 ENOG4105F0F Oxalate decarboxylase S100757_03373 ENOG4107RBB ABC transporter, permease S100757_03374 ENOG4105C19 ABC transporter S100757_03375 ENOG4108WMK Efflux transporter RND family MFP subunit S100757_03376 ENOG4105E0A ABC, transporter S100757_03377 ENOG4105EHG Permease protein S100757_03378 ENOG4105DQ5 transport system permease protein S100757_03381 ENOG4105D5Q Arginine ornithine antiporter S100757_03383 ENOG4107K5X Membrane-bound metal-dependent hydrolase S100757_03384 ENOG4107QZ2 Sulfatase S100757_03385 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family S100757_03386 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein S100757_03387 ENOG4105E0C molybdate abc transporter S100757_03390 ENOG4105EEQ Na H antiporter S100757_03391 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) S100757_03392 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S100757_03393 ENOG4105EEM helicase S100757_03395 ENOG4105EN6 Membrane S100757_03397 ENOG4107ZQN disulfide bond S100757_03398 ENOG4105C59 p-type ATPase S100757_03399 ENOG4105C59 p-type ATPase S100757_03400 ENOG410681U heavy metal transport detoxification protein S100757_03401 ENOG4105VPX protein, conserved in bacteria S100757_03402 ENOG4105D9R oxidoreductase S100757_03403 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) S100757_03404 ENOG4105ME7 Membrane S100757_03405 ENOG4105RXJ S100757_03406 ENOG4105KPY Small multidrug resistance protein S100757_03407 ENOG4105KBX Transcriptional regulator, TetR family S100757_03408 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S100757_03409 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) S100757_03410 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) S100757_03412 ENOG4105XZU Preprotein translocase, subunit SecG S100757_03417 ENOG4105KVH Transcriptional regulator S100757_03418 ENOG4105C8Q Methyl-accepting chemotaxis S100757_03419 ENOG4105R40 Glycine betaine carnitine choline S100757_03420 ENOG4108HQR Glycine betaine S100757_03421 ENOG4105E90 ABC transporter S100757_03422 ENOG4108IJ8 ABC transporter S100757_03423 ENOG4107HG4 Transcriptional regulator S100757_03424 ENOG4105R40 Glycine betaine carnitine choline S100757_03425 ENOG4108HQR Glycine betaine S100757_03426 ENOG4105E90 ABC transporter S100757_03427 ENOG4108IJ8 ABC transporter S100757_03428 ENOG4107HG4 Transcriptional regulator S100757_03429 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein S100757_03430 ENOG4108QCI YvbH-like oligomerisation region S100757_03432 ENOG4105T65 Membrane-associated protein S100757_03433 ENOG4108W0I acetyltransferase S100757_03434 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) S100757_03435 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) S100757_03436 ENOG4105CP7 Triose-phosphate isomerase S100757_03437 ENOG4105BZA Phosphoglycerate kinase S100757_03438 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S100757_03441 ENOG4105CMD Transcriptional regulator, GntR family S100757_03442 ENOG4105DEN Luciferase family S100757_03443 ENOG4105GZI Transcriptional regulator S100757_03444 ENOG4107RT3 EamA-like transporter family S100757_03446 ENOG4105VRS hydrolase family 18 S100757_03447 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) S100757_03448 ENOG4107QR9 Iron-sulfur cluster binding protein S100757_03449 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S100757_03453 ENOG4105BZU Histidine kinase S100757_03454 ENOG4105KCT ABC transporter S100757_03455 ENOG4108M15 ABC transporter S100757_03457 ENOG4107R6F Alpha Beta Hydrolase Fold protein S100757_03458 ENOG4108MJI response regulator S100757_03461 ENOG4105EG2 ABC transporter, permease S100757_03463 ENOG4107FKK extracellular solute-binding protein family 1 S100757_03465 ENOG4105JXH GntR family transcriptional regulator S100757_03466 ENOG4105DAA L-lactate S100757_03467 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100757_03469 ENOG4108ZPC Polysaccharide pyruvyl transferase S100757_03470 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S100757_03471 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family S100757_03472 ENOG4105D3Q Sugar transferase S100757_03474 ENOG4105K64 Glycosyl transferase, family 2 S100757_03476 ENOG4107QRS glycosyltransferase group 2 family protein S100757_03477 ENOG41068W6 Capsular polysaccharide biosynthesis protein S100757_03478 ENOG4108KMV Glycosyl transferase (Group 1 S100757_03479 ENOG4105K64 Glycosyl transferase, family 2 S100757_03480 ENOG4108PQP glycosyl transferase group 1 S100757_03482 ENOG4108QV3 biosynthesis protein S100757_03483 ENOG4105HTX biosynthesis protein S100757_03485 ENOG4105EBR Carboxylesterase S100757_03487 ENOG4105PY6 Phenolic acid decarboxylase S100757_03488 ENOG4105NI3 Protein of unknown function (DUF3237) S100757_03490 ENOG4105FQP Beta-lactamase S100757_03491 ENOG4105EDQ levansucrase EC 2.4.1.10 S100757_03492 ENOG4108HKT sucrose-6-phosphate hydrolase S100757_03493 ENOG4107QTZ amino acid S100757_03499 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S100757_03500 ENOG4107URF beta-phospho-glucomutase S100757_03501 ENOG4105CG3 alpha amylase, catalytic region S100757_03504 ENOG4105EG2 ABC transporter, permease S100757_03505 ENOG4105D56 permease protein S100757_03506 ENOG4107FKK extracellular solute-binding protein family 1 S100757_03507 ENOG4108IUK alpha amylase, catalytic S100757_03508 ENOG4105FKQ transcriptional regulator S100757_03509 ENOG4108URH decarboxylase S100757_03510 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain S100757_03511 ENOG4105CHH sulfate transporter S100757_03512 ENOG4108V2W Carbonate dehydratase S100757_03513 ENOG4105C5I Dehydrogenase S100757_03515 ENOG4105C19 ABC transporter S100757_03516 ENOG4105EWM Histidine kinase S100757_03518 ENOG4107A6P S100757_03519 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase S100757_03520 ENOG4105KRI phosphocarrier protein (HPr S100757_03521 ENOG4105CIE May be required for sporulation (By similarity) S100757_03522 ENOG4105CHW UPF0052 protein S100757_03523 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) S100757_03524 ENOG4108Z4K mutator MutT protein S100757_03525 ENOG4105C3M thioredoxin reductase S100757_03528 ENOG4105BZ1 (ABC) transporter S100757_03530 ENOG4106FGC S100757_03532 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase S100757_03533 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) S100757_03534 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase S100757_03535 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) S100757_03536 ENOG4105ECC imidazole-glycerol-phosphate dehydratase S100757_03537 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) S100757_03538 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) S100757_03539 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) S100757_03541 ENOG4108E16 pectate lyase S100757_03542 ENOG4108S4C acetyltransferase S100757_03543 ENOG4107XGZ Hydrolase S100757_03544 ENOG4105HKU nucleoside recognition domain-containing protein S100757_03545 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) S100757_03546 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) S100757_03547 ENOG4105CE4 GlcNAc 6-P deacetylase S100757_03548 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) S100757_03549 ENOG4105FDP GntR family transcriptional regulator S100757_03550 ENOG41088CQ domain protein S100757_03552 ENOG4106A3M Cytochrome p-450 S100757_03553 ENOG410625E S100757_03556 ENOG41086DT Membrane protein of unknown function S100757_03557 ENOG41067S9 phage shock protein C, PspC S100757_03558 ENOG4108PY7 S100757_03561 ENOG4105I03 Flagellin S100757_03562 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) S100757_03563 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) S100757_03566 ENOG4105MKU Transcriptional regulator S100757_03570 ENOG4105CN1 protease S100757_03571 ENOG4105CRP Part of the ABC transporter FtsEX involved in S100757_03572 ENOG4105CAK Cell division ATP-binding protein ftsE S100757_03575 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) S100757_03577 ENOG4105MS2 ribosomal subunit Interface protein S100757_03580 ENOG4105MQ3 flagellar protein FliS S100757_03581 ENOG4107RT6 flagellar hook-associated S100757_03582 ENOG41083S7 flagellar protein FlaG S100757_03583 ENOG4105I03 Flagellin S100757_03584 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) S100757_03585 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) S100757_03586 ENOG4105MKD S100757_03587 ENOG4105DTJ flagellar hook-associated protein S100757_03588 ENOG4105E1Q flagellar hook-associated protein S100757_03591 ENOG4105RU3 S100757_03592 ENOG41081UC Inherit from COG: Competence protein S100757_03596 ENOG4105WH1 Two component transcriptional regulator luxr family S100757_03597 ENOG4105BZU Histidine kinase S100757_03598 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein S100757_03599 ENOG4108KGH TRANSCRIPTIONal S100757_03606 ENOG4108RDQ ABC transporter S100757_03608 ENOG4105ESV Glycosyl transferase, family 4 S100757_03609 ENOG4107EF8 Glycosyl transferase (Group 1 S100757_03612 ENOG4105QZI O-Antigen Polymerase S100757_03614 ENOG4105C6Y Udp-glucose 6-dehydrogenase S100757_03615 ENOG4107RA4 Glycosyl transferase (Group 1 S100757_03616 ENOG4105PSV Polysaccharide Biosynthesis Protein S100757_03617 ENOG4105D3Q Sugar transferase S100757_03618 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S100757_03619 ENOG4105JFG SpoIID LytB domain protein S100757_03621 ENOG4108KGH TRANSCRIPTIONal S100757_03622 ENOG4108KGH TRANSCRIPTIONal S100757_03623 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase S100757_03624 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S100757_03626 ENOG4105EY8 ABC transporter S100757_03630 ENOG4107SJB teichoic acid biosynthesis S100757_03631 ENOG4107SJB teichoic acid biosynthesis S100757_03632 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase S100757_03634 ENOG4107RZX Teichoic acid biosynthesis protein S100757_03636 ENOG4105DG6 mannose-6-phosphate isomerase S100757_03639 ENOG4108NHD germination protein S100757_03640 ENOG4105C54 Major Facilitator superfamily S100757_03641 ENOG4108KGH TRANSCRIPTIONal S100757_03642 ENOG4105J7I hydrolase S100757_03643 ENOG4105DQ6 Transposase S100757_03645 ENOG4105K4H Nlp p60 protein S100757_03647 ENOG4105PNM synthesis protein S100757_03649 ENOG4105N98 Capsule biosynthesis protein capB S100757_03650 ENOG4105ETE Transcriptional regulator (LacI family S100757_03651 ENOG4108RVA ribokinase S100757_03652 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) S100757_03653 ENOG4105C2J ABC transporter S100757_03654 ENOG4105CNN ABC, transporter S100757_03655 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator S100757_03658 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein S100757_03659 ENOG4107FQX Alpha-acetolactate decarboxylase S100757_03661 ENOG4107RSM transcriptional regulator S100757_03664 ENOG4106UIA S100757_03664 ENOG4106UIA S100757_03667 ENOG4107XC4 flavin reductase domain protein, FMN-binding S100757_03669 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S100757_03671 ENOG4105CAH Chromate S100757_03672 ENOG4105FGV Chromate S100757_03674 ENOG4108WS4 fmn reductase S100757_03675 ENOG4107V2S Transcriptional regulator S100757_03676 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) S100757_03685 ENOG4108XI2 Domain of unknown function (DUF1963) S100757_03686 ENOG4105C6Y Udp-glucose 6-dehydrogenase S100757_03687 ENOG4108RB3 Capsular polysaccharide biosynthesis protein S100757_03688 ENOG4107YJ4 chain length determinant protein S100757_03689 ENOG4105HTX biosynthesis protein S100757_03691 ENOG4105KBK Zinc finger, swim domain protein S100757_03692 ENOG4105C0D helicase S100757_03693 ENOG410667J hydrolase S100757_03694 ENOG4105E98 transcriptional regulator DeoR family S100757_03695 ENOG4105Z8H single-stranded DNA-binding protein S100757_03701 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) S100757_03702 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) S100757_03704 ENOG4105CGA flagellar basal-body rod protein FlgG S100757_03706 ENOG4105DFF Rod shape-determining protein mreb S100757_03707 ENOG4105MT0 Sporulation transcriptional regulator spoiiid S100757_03708 ENOG4107MII Sugar-specific transcriptional regulator TrmB S100757_03709 ENOG4105CZM Major Facilitator S100757_03710 ENOG4108M26 parallel beta-helix repeat protein S100757_03711 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease S100757_03712 ENOG41080V3 Major Facilitator superfamily S100757_03713 ENOG4105D3W isochorismatase S100757_03714 ENOG4107P26 S100757_03715 ENOG4105BZU Histidine kinase S100757_03717 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase S100757_03719 ENOG4105FRN stage II sporulation protein S100757_03720 ENOG4107TCE N-acetyltransferase S100757_03724 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S100757_03725 ENOG4107TXC Transcriptional regulator S100757_03726 ENOG4106BRK S100757_03727 ENOG4108RYK Nad-dependent epimerase dehydratase S100757_03728 ENOG4108Z40 Transcriptional regulator S100757_03729 ENOG4105CQM Urea amidohydrolase subunit alpha S100757_03730 ENOG4105KI2 Urea amidohydrolase subunit beta S100757_03731 ENOG4108YZ9 Urea amidohydrolase subunit gamma S100757_03736 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) S100757_03738 ENOG4108TF4 von Willebrand factor, type A S100757_03740 ENOG4105JFG SpoIID LytB domain protein S100757_03741 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S100757_03743 ENOG4106778 Protein of unknown function (DUF1146) S100757_03745 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) S100757_03746 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) S100757_03747 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) S100757_03748 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) S100757_03752 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) S100757_03754 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) S100757_03755 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) S100757_03756 ENOG4108UIC UPF0340 protein S100757_03757 ENOG4108YZG isomerase S100757_03758 ENOG4107WAU Protein tyrosine phosphatase S100757_03759 ENOG410815N Probably functions as a manganese efflux pump (By similarity) S100757_03760 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S100757_03762 ENOG4108ZXQ stage ii sporulation protein r S100757_03765 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) S100757_03766 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) S100757_03767 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase S100757_03769 ENOG4107TT2 Auxin Efflux Carrier S100757_03770 ENOG4105C6K Malic enzyme S100757_03771 ENOG4107104 thymidine kinase S100757_03772 ENOG41082DI 50s ribosomal protein l31 S100757_03773 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) S100757_03774 ENOG4105CBT Fructose-1,6-bisphosphatase S100757_03775 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S100757_03776 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway S100757_03777 ENOG4105D2N Aldolase S100757_03778 ENOG410812K response regulator receiver protein S100757_03780 ENOG4105DQ6 Transposase S100757_03782 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) S100757_03784 ENOG4105C1G acyl-Coa dehydrogenase S100757_03785 ENOG4105DF6 Fe-S oxidoreductase S100757_03787 ENOG4105E5J UV damage endonuclease S100757_03789 ENOG4105NAE bifunctional deaminase-reductase domain protein S100757_03790 ENOG4105BZ1 (ABC) transporter S100757_03791 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S100757_03793 ENOG4105R3A Nitrate reductase S100757_03794 ENOG4108IUE nitrate reductase beta subunit S100757_03798 ENOG4107V6Q Cyclic nucleotide-binding domain S100757_03800 ENOG4105C75 arginyL-tRNA synthetase S100757_03801 ENOG410684U Domain of unknown function (DUF1934) S100757_03803 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E S100757_03812 ENOG4107JM4 Tetratricopeptide repeat S100757_03814 ENOG4108UIN ybak prolyl-trna synthetase associated region S100757_03815 ENOG4105CYW agmatinase S100757_03816 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) S100757_03817 ENOG4105BZ4 penicillin-binding protein S100757_03818 ENOG4108XFG YwhD family S100757_03819 ENOG4108Z4T Peptidase M50 S100757_03820 ENOG41069HH 4-oxalocrotonate tautomerase S100757_03821 ENOG41067TZ transcriptional regulator, MarR family S100757_03822 ENOG4105C22 threonyL-tRNA synthetase S100757_03824 ENOG4105C57 major facilitator superfamily S100757_03825 ENOG41062ES Transcriptional regulator S100757_03827 ENOG4105DCI Phosphohydrolase S100757_03829 ENOG4108VCI transcription factor, rsfa family S100757_03830 ENOG4108RNG Permease of the drug metabolite transporter S100757_03831 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) S100757_03832 ENOG4105DUM transcriptional regulator, lysR family S100757_03833 ENOG4108IJ2 phosphate acetyltransferase S100757_03836 ENOG4105CHM Aminotransferase S100757_03838 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase S100757_03839 ENOG4105CHR reductase S100757_03840 ENOG4106CHD Bacilysin biosynthesis protein bacB S100757_03841 ENOG41061WN bacilysin biosynthesis protein S100757_03842 ENOG4105FCW Major Facilitator superfamily S100757_03845 ENOG4105C26 Dehydrogenase S100757_03846 ENOG4105D82 Glutamate dehydrogenase S100757_03848 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase S100757_03849 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase S100757_03850 ENOG4105C1B dTDP-glucose 4-6-dehydratase S100757_03851 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) S100757_03852 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG S100757_03853 ENOG4107TY6 Acylneuraminate cytidylyltransferase S100757_03855 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD S100757_03856 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S100757_03863 ENOG4105C26 Dehydrogenase S100757_03864 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) S100757_03865 ENOG4108RJ9 Glycosyl transferase, family 2 S100757_03866 ENOG4105DWF phosphomethylpyrimidine kinase S100757_03869 ENOG4105C5Y PTS System S100757_03870 ENOG4108QTI )-transporter S100757_03873 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin S100757_03874 ENOG4105DEN Luciferase family S100757_03875 ENOG4108DBC nitroreductase S100757_03879 ENOG41060D1 Quinol oxidase S100757_03880 ENOG4105CCU oxidase (Subunit III) S100757_03881 ENOG4105BZ9 Cytochrome C oxidase, subunit I S100757_03882 ENOG4105E2S oxidase) subunit II S100757_03883 ENOG4107BMA Transglycosylase associated protein S100757_03885 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) S100757_03886 ENOG4105WH5 Teichoic acid glycosylation protein S100757_03891 ENOG4107ZXU DSBA oxidoreductase S100757_03892 ENOG4105DBE peroxidase S100757_03893 ENOG410650H (LipO)protein S100757_03894 ENOG4107SJW iron permease, FTR1 S100757_03895 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) S100757_03897 ENOG4105CMU LysR family (Transcriptional regulator S100757_03898 ENOG4105VAW lrga family S100757_03899 ENOG41067MG lrgb family S100757_03900 ENOG4105D8G Major Facilitator superfamily S100757_03902 ENOG4105DR4 Methyltransferase S100757_03904 ENOG4108YV3 Protein of unknown function (DUF2711) S100757_03905 ENOG4105CK1 PTS System S100757_03906 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin S100757_03909 ENOG4105X1N Glycosyl transferase family 8 S100757_03911 ENOG4105GVJ transcriptional regulator S100757_03912 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S100757_03913 ENOG4105IIU Aminopeptidase S100757_03915 ENOG4105DQ6 Transposase S100757_03917 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase S100757_03919 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) S100757_03920 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein S100757_03922 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD S100757_03923 ENOG4108VHC Short-chain dehydrogenase reductase Sdr S100757_03924 ENOG4105CM2 brancheD-chain amino acid aminotransferase S100757_03925 ENOG4105F8D glycoside hydrolase family 4 S100757_03926 ENOG4105VCP PTS System S100757_03927 ENOG4105CK1 PTS System S100757_03928 ENOG4105VZJ PTS System S100757_03929 ENOG4105EMD TRANSCRIPTIONal S100757_03931 ENOG4108VX5 3-methyladenine DNA glycosylase S100757_03932 ENOG4105CH6 catalase S100757_03935 ENOG4105DA5 (ABC) transporter S100757_03936 ENOG41069JR S100757_03940 ENOG4105ETS cytosine purines uracil thiamine allantoin S100757_03941 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) S100757_03942 ENOG4108JJ8 (ABC) transporter S100757_03943 ENOG4108JJ9 ABC, transporter S100757_03944 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii S100757_03945 ENOG4105C4M (Ubiquinol oxidase) subunit I S100757_03946 ENOG4105D2K citrate carrier protein S100757_03949 ENOG4107BJW polysaccharide deacetylase S100757_03953 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) S100757_03955 ENOG4105CMR udp-glucose 4-epimerase S100757_03957 ENOG4105BZU Histidine kinase S100757_03958 ENOG4105WH1 Two component transcriptional regulator luxr family S100757_03959 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S100757_03964 ENOG4105DTD Dehydrogenase S100757_03965 ENOG4108IIH CoA-transferase subunit B S100757_03966 ENOG4105D6N CoA-transferase, subunit a S100757_03967 ENOG4105CY2 Citrate transporter S100757_03968 ENOG4105DHI Methyltransferase S100757_03972 ENOG4105CH6 catalase S100757_03973 ENOG4105D4T Citrate transporter S100757_03974 ENOG4108RZ2 Glycoside hydrolase family 16 S100757_03975 ENOG4105CID antiterminator S100757_03977 ENOG4105DEU major facilitator superfamily S100757_03978 ENOG4105C1J atp-dependent rna helicase S100757_03979 ENOG4107TDE lipolytic protein G-D-S-L family S100757_04004 ENOG4107YZX Universal stress protein S100757_04005 ENOG4105CS2 ec 3.2.1.21 S100757_04006 ENOG4105C5Y PTS System S100757_04008 ENOG4107EV6 Inherit from COG: YD repeat protein S100757_04010 ENOG4107EV6 Inherit from COG: YD repeat protein S100757_04013 ENOG4106Z5D Glycoside Hydrolase Family 43 S100757_04015 ENOG4105C84 Histidine ammonia-lyase S100757_04016 ENOG4105CGP Urocanate hydratase S100757_04017 ENOG4105CI2 imidazolone-5-propionate hydrolase S100757_04018 ENOG4107W25 arginase agmatinase formiminoglutamase S100757_04020 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) S100757_04021 ENOG4105D9N nucleoside S100757_04023 ENOG4107RHR regulatoR S100757_04024 ENOG4108TM9 integral membrane protein S100757_04025 ENOG4105ENY Ethanolamine utilization protein eutH S100757_04026 ENOG4108PGP mmge prpd family protein S100757_04027 ENOG4105CH2 amidohydrolase S100757_04029 ENOG4108HW4 amino acid AbC transporter S100757_04030 ENOG4105EAB amino acid AbC transporter S100757_04031 ENOG4108XSB acetyltransferase, (GNAT) family S100757_04032 ENOG4105CPU Monooxygenase S100757_04033 ENOG4107QHE Choloylglycine hydrolase S100757_04034 ENOG410667J hydrolase S100757_04040 ENOG4108V5C ABC transporter S100757_04046 ENOG4105D2N Aldolase S100757_04047 ENOG4107TRN Xylose isomerase domain protein TIM barrel S100757_04048 ENOG4105F0H myo-inositol catabolism protein S100757_04049 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S100757_04051 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) S100757_04052 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) S100757_04053 ENOG4105D7K pfkb domain protein S100757_04055 ENOG4105C26 Dehydrogenase S100757_04057 ENOG4105CPC Aldo Keto reductase S100757_04060 ENOG4107QNK )-transporter S100757_04061 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) S100757_04063 ENOG41061TZ Short-chain dehydrogenase reductase Sdr S100757_04064 ENOG4105ST3 Transcriptional regulator S100757_04065 ENOG4105C26 Dehydrogenase S100757_04066 ENOG41085PJ rdd domain containing protein S100757_04068 ENOG41085PJ rdd domain containing protein S100757_04071 ENOG4105J7D transcriptional regulator S100757_04072 ENOG4107JEE Short-chain dehydrogenase reductase Sdr S100757_04073 ENOG41061AU MarR family Transcriptional regulator S100757_04075 ENOG41067MG lrgb family S100757_04077 ENOG4105BZW Glycerate kinase S100757_04078 ENOG4105G3Z GntR family transcriptional regulator S100757_04079 ENOG4105CMG Carbohydrate kinase S100757_04080 ENOG4105C6Z Gluconate S100757_04081 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) S100757_04082 ENOG4105D3R alkyl hydroperoxide reductase S100757_04083 ENOG4108JU3 Alkyl hydroperoxide reductase S100757_04084 ENOG4105CS2 ec 3.2.1.21 S100757_04085 ENOG4105C5Y PTS System S100757_04086 ENOG4108S3Y transcriptional regulator S100757_04087 ENOG4107QKA exodeoxyribonuclease V beta S100757_04088 ENOG4105D0M Protease HtpX homolog S100757_04092 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 S100757_04094 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) S100757_04097 ENOG4105E2A Dehydrogenase S100757_04101 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) S100757_04102 ENOG4105WQG acetyltransferase S100757_04103 ENOG410780I phosphoprotein phosphatase activity S100757_04104 ENOG410780I phosphoprotein phosphatase activity S100757_04106 ENOG41066UZ arginase EC 3.5.3.1 S100757_04107 ENOG4108IQI permease S100757_04108 ENOG4105C8Y Acetylornithine aminotransferase S100757_04113 ENOG41082BM Transcriptional regulator, arsr family S100757_04114 ENOG4108JUB Transcriptional regulator S100757_04115 ENOG4105C0H protease S100757_04116 ENOG4105Q2H domain protein S100757_04119 ENOG4105BZU Histidine kinase S100757_04120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S100757_04125 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis S100757_04126 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase S100757_04127 ENOG4105CDU Replicative dna helicase S100757_04131 ENOG4105DJ2 Major Facilitator Superfamily S100757_04132 ENOG4105EDW glycosyl transferase, family 39 S100757_04133 ENOG4105K9Q Binds to the 23S rRNA (By similarity) S100757_04134 ENOG4105BZR domain protein S100757_04135 ENOG4108XMW Membrane S100757_04138 ENOG4105KVH Transcriptional regulator S100757_04139 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase S100757_04143 ENOG41090E6 transcriptional regulator MERR family S100757_04145 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein S100757_04146 ENOG4105DDN Pentapeptide repeat-containing protein S100757_04147 ENOG4105D94 Major Facilitator Superfamily S100757_04148 ENOG4107RSM transcriptional regulator S100757_04149 ENOG41082BV acetyltransferase S100757_04150 ENOG41081I9 integral membrane protein S100757_04152 ENOG4108U05 Transcriptional regulator S100757_04153 ENOG41082BV acetyltransferase S100757_04155 ENOG4108U7W acetyltransferase S100757_04156 ENOG4105UNS Pfam:DUF419 S100757_04157 ENOG4105NAE bifunctional deaminase-reductase domain protein S100757_04158 ENOG4105C7Z Conserved Protein S100757_04159 ENOG4107FCW Abortive infection protein S100757_04161 ENOG4108UW5 maltose o-acetyltransferase S100757_04162 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase S100757_04164 ENOG4105CGK Exodeoxyribonuclease III S100757_04165 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) S100757_04166 ENOG4108UUM single-stranded DNA-binding protein S100757_04167 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) S100757_04168 ENOG4105C3G gtp-binding protein S100757_04169 ENOG4108J2R molybdopterin oxidoreductase S100757_04170 ENOG4105VDK protein, conserved in bacteria S100757_04172 ENOG4108ZDA Sporulation protein YyaC S100757_04173 ENOG4105FA0 parb-like partition protein S100757_04174 ENOG4107QJE Chromosome Partitioning Protein S100757_04177 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) S100757_04178 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) S100757_04179 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) S100757_04182 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)