locus-tag	class	description
S100761_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S100761_00002	COG0592	DNA-directed DNA polymerase activity
S100761_00003	COG2501	S4 domain
S100761_00004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S100761_00006	COG0187	DNA topoisomerase II activity
S100761_00007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100761_00014	COG0517	IMP dehydrogenase activity
S100761_00014	COG0516	GMP reductase activity
S100761_00015	COG1686	Belongs to the peptidase S11 family
S100761_00016	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
S100761_00017	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
S100761_00018	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S100761_00020	COG1428	Deoxynucleoside kinase
S100761_00021	COG1428	Deoxynucleoside kinase
S100761_00022	COG3858	chitin binding
S100761_00022	COG1388	LysM domain
S100761_00023	COG1335	isochorismatase
S100761_00024	COG0590	tRNA wobble adenosine to inosine editing
S100761_00025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S100761_00026	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S100761_00027	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S100761_00036	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
S100761_00037	COG3853	Toxic anion resistance protein (TelA)
S100761_00038	COG1982	Orn Lys Arg decarboxylase major
S100761_00039	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S100761_00040	COG3870	Protein conserved in bacteria
S100761_00041	COG1728	Protein conserved in bacteria
S100761_00042	COG0470	DNA polymerase III
S100761_00043	COG1774	PSP1 C-terminal conserved region
S100761_00044	COG4467	Involved in initiation control of chromosome replication
S100761_00045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S100761_00046	COG2827	Endonuclease containing a URI domain
S100761_00047	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S100761_00048	COG2002	toxin-antitoxin pair type II binding
S100761_00049	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100761_00049	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100761_00050	COG0084	hydrolase, TatD family'
S100761_00051	COG3584	3D domain protein
S100761_00051	COG3583	domain protein
S100761_00052	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100761_00053	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S100761_00055	COG4466	Protein conserved in bacteria
S100761_00057	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S100761_00058	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100761_00059	COG0251	oxidation-reduction process
S100761_00060	COG2088	sporulation resulting in formation of a cellular spore
S100761_00061	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S100761_00062	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S100761_00063	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S100761_00064	COG0193	aminoacyl-tRNA hydrolase activity
S100761_00066	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S100761_00067	COG2002	toxin-antitoxin pair type II binding
S100761_00068	COG2244	polysaccharide biosynthetic process
S100761_00069	COG3956	TIGRFAM MazG family protein
S100761_00070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S100761_00073	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S100761_00074	COG1098	S1 RNA binding domain
S100761_00077	COG2208	phosphoserine phosphatase activity
S100761_00078	COG2304	oxidoreductase activity
S100761_00079	COG0515	serine threonine protein kinase
S100761_00080	COG0037	tRNA processing
S100761_00082	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100761_00083	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S100761_00084	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S100761_00085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100761_00086	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100761_00087	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100761_00088	COG0512	Glutamine amidotransferase of anthranilate synthase
S100761_00089	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100761_00090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S100761_00091	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S100761_00092	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S100761_00093	COG1396	sequence-specific DNA binding
S100761_00094	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100761_00095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S100761_00111	COG4463	regulation of RNA biosynthetic process
S100761_00112	COG3880	PFAM UvrB UvrC protein
S100761_00113	COG3869	Catalyzes the specific phosphorylation of arginine residues in
S100761_00114	COG0542	response to heat
S100761_00115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S100761_00116	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S100761_00117	COG4956	integral membrane protein (PIN domain superfamily)
S100761_00118	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S100761_00119	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S100761_00120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S100761_00121	COG1045	serine acetyltransferase
S100761_00122	COG0215	cysteine-tRNA ligase activity
S100761_00123	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S100761_00124	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100761_00125	COG3688	RNA-binding protein containing a PIN domain
S100761_00126	COG1595	DNA-templated transcription, initiation
S100761_00127	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100761_00128	COG0250	Participates in transcription elongation, termination and antitermination
S100761_00129	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S100761_00130	COG0081	regulation of translation
S100761_00131	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S100761_00132	COG0222	ribosome binding
S100761_00133	COG2813	Specifically methylates the guanine in position
S100761_00134	COG0085	RNA polymerase activity
S100761_00135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S100761_00136	COG1358	cellular component organization or biogenesis
S100761_00137	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S100761_00138	COG0049	tRNA binding
S100761_00139	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S100761_00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S100761_00141	COG0596	Alpha beta hydrolase
S100761_00142	COG0051	transcription antitermination factor activity, RNA binding
S100761_00143	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S100761_00144	COG0088	Forms part of the polypeptide exit tunnel
S100761_00145	COG0089	rRNA binding
S100761_00146	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S100761_00147	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S100761_00148	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S100761_00149	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S100761_00150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S100761_00151	COG0255	Belongs to the universal ribosomal protein uL29 family
S100761_00152	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S100761_00153	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S100761_00155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S100761_00157	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S100761_00158	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S100761_00159	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S100761_00161	COG1841	ribosomal large subunit assembly
S100761_00162	COG0200	Binds to the 23S rRNA
S100761_00163	COG0201	protein transport
S100761_00164	COG0563	adenylate kinase activity
S100761_00165	COG0024	Methionine aminopeptidase
S100761_00166	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S100761_00167	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S100761_00168	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S100761_00169	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S100761_00170	COG0202	RNA polymerase activity
S100761_00171	COG0203	ribosomal protein L17
S100761_00172	COG1122	ATPase activity
S100761_00173	COG1122	ATPase activity
S100761_00174	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100761_00175	COG0101	tRNA pseudouridine synthase activity
S100761_00176	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S100761_00177	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S100761_00178	COG2226	methyltransferase
S100761_00180	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100761_00181	COG0489	protein tyrosine kinase activity
S100761_00183	COG2194	sulfuric ester hydrolase activity
S100761_00184	COG0726	polysaccharide deacetylase
S100761_00200	COG0659	secondary active sulfate transmembrane transporter activity
S100761_00202	COG0385	Bile acid
S100761_00203	COG2819	hydrolase of the alpha beta superfamily
S100761_00204	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_00205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_00206	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100761_00207	COG2207	Transcriptional regulator
S100761_00207	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100761_00208	COG3876	Protein conserved in bacteria
S100761_00209	COG1472	Belongs to the glycosyl hydrolase 3 family
S100761_00210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100761_00211	COG1263	PTS System
S100761_00211	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_00212	COG1737	Transcriptional regulator
S100761_00213	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S100761_00214	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_00215	COG1683	Conserved Protein
S100761_00221	COG1595	DNA-templated transcription, initiation
S100761_00222	COG5662	AntiSigma factor
S100761_00223	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S100761_00224	COG4856	YbbR-like protein
S100761_00225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100761_00226	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S100761_00227	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S100761_00228	COG2169	Transcriptional regulator
S100761_00229	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100761_00230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100761_00231	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100761_00232	COG3002	Belongs to the UPF0753 family
S100761_00233	COG0288	reversible hydration of carbon dioxide
S100761_00235	COG5609	conserved protein (DUF2294)
S100761_00236	COG0640	Transcriptional regulator
S100761_00237	COG2814	Major facilitator Superfamily
S100761_00239	COG0596	Alpha beta hydrolase
S100761_00240	COG0745	RESPONSE REGULATOR receiver
S100761_00241	COG0642	Histidine kinase
S100761_00243	COG0515	serine threonine protein kinase
S100761_00246	COG1113	amino acid transport
S100761_00249	COG2602	Beta-lactamase
S100761_00250	COG2124	cytochrome p450
S100761_00252	COG0531	amino acid
S100761_00253	COG0584	glycerophosphoryl diester phosphodiesterase
S100761_00254	COG2271	Major facilitator Superfamily
S100761_00256	COG0456	acetyltransferase
S100761_00256	COG1846	Transcriptional regulator
S100761_00257	COG2271	Major facilitator Superfamily
S100761_00258	COG0697	spore germination
S100761_00259	COG1917	Cupin 2, conserved barrel domain protein
S100761_00259	COG2207	Transcriptional regulator
S100761_00264	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
S100761_00265	COG3591	Belongs to the peptidase S1B family
S100761_00267	COG0596	Alpha beta hydrolase
S100761_00268	COG1183	phosphatidylcholine synthase activity
S100761_00269	COG0586	Pfam SNARE associated Golgi protein
S100761_00270	COG0688	phosphatidylethanolamine metabolic process
S100761_00272	COG2312	Erythromycin esterase
S100761_00273	COG2207	Transcriptional regulator
S100761_00275	COG1301	dicarboxylic acid transport
S100761_00276	COG2190	(PTS) system
S100761_00276	COG1263	PTS System
S100761_00276	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_00277	COG0363	glucosamine-6-phosphate deaminase activity
S100761_00280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100761_00281	COG0833	amino acid
S100761_00282	COG2040	homocysteine
S100761_00284	COG1115	amino acid carrier protein
S100761_00285	COG2066	Belongs to the glutaminase family
S100761_00286	COG4191	Histidine kinase
S100761_00287	COG0784	Response regulator, receiver
S100761_00288	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100761_00289	COG1012	belongs to the aldehyde dehydrogenase family
S100761_00290	COG2271	Major facilitator Superfamily
S100761_00291	COG4948	Mandelate Racemase Muconate Lactonizing
S100761_00292	COG2186	Transcriptional regulator
S100761_00293	COG2721	sulfolactate sulfo-lyase activity
S100761_00294	COG3173	Aminoglycoside phosphotransferase
S100761_00296	COG0697	spore germination
S100761_00297	COG0745	RESPONSE REGULATOR receiver
S100761_00298	COG2205	protein histidine kinase activity
S100761_00299	COG1131	(ABC) transporter
S100761_00302	COG3773	Cell wall hydrolase
S100761_00303	COG2304	oxidoreductase activity
S100761_00304	COG3540	Alkaline phosphatase
S100761_00305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100761_00306	COG0805	protein transport
S100761_00307	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
S100761_00308	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100761_00309	COG0477	Major facilitator Superfamily
S100761_00310	COG1309	transcriptional regulator
S100761_00311	COG0252	asparaginase activity
S100761_00312	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S100761_00313	COG1714	RDD family
S100761_00314	COG1405	negative regulation of cell septum assembly
S100761_00314	COG3012	SEC-C Motif Domain Protein
S100761_00315	COG3290	protein histidine kinase activity
S100761_00316	COG3279	Response regulator of the LytR AlgR family
S100761_00317	COG4555	ABC transporter
S100761_00318	COG1668	transmembrane transport
S100761_00319	COG0667	Aldo Keto reductase
S100761_00321	COG1595	DNA-templated transcription, initiation
S100761_00322	COG1595	DNA-templated transcription, initiation
S100761_00323	COG1876	peptidase activity
S100761_00324	COG0457	Tetratricopeptide repeat
S100761_00325	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_00326	COG0366	Alpha amylase catalytic
S100761_00327	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100761_00328	COG1121	(ABC) transporter
S100761_00329	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100761_00330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100761_00331	COG2310	stress, protein
S100761_00332	COG2310	stress, protein
S100761_00333	COG2310	stress, protein
S100761_00334	COG0861	Integral membrane protein TerC family
S100761_00336	COG3853	Toxic anion resistance protein (TelA)
S100761_00337	COG0477	Major facilitator Superfamily
S100761_00338	COG2814	Major facilitator Superfamily
S100761_00339	COG0640	Transcriptional regulator
S100761_00340	COG0517	IMP dehydrogenase activity
S100761_00340	COG4175	Glycine betaine
S100761_00341	COG4176	ABC-type proline glycine betaine transport system permease component
S100761_00342	COG2113	Glycine betaine
S100761_00343	COG1473	amidohydrolase
S100761_00344	COG1288	antiporter activity
S100761_00346	COG0366	Alpha amylase catalytic
S100761_00347	COG0039	L-malate dehydrogenase activity
S100761_00348	COG1620	l-lactate permease
S100761_00349	COG2814	Major facilitator Superfamily
S100761_00350	COG1846	Transcriptional regulator
S100761_00351	COG1280	lysine exporter protein (LysE YggA)
S100761_00352	COG3403	YqcI/YcgG family
S100761_00353	COG1113	amino acid transport
S100761_00354	COG3665	Urea carboxylase-associated protein
S100761_00355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S100761_00356	COG1660	Displays ATPase and GTPase activities
S100761_00357	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S100761_00358	COG2226	methyltransferase
S100761_00359	COG0583	DNA-binding transcription factor activity
S100761_00360	COG3458	cephalosporin-C deacetylase activity
S100761_00361	COG3541	Predicted nucleotidyltransferase
S100761_00362	COG0506	proline dehydrogenase activity
S100761_00363	COG1012	belongs to the aldehyde dehydrogenase family
S100761_00364	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100761_00365	COG2508	Transcriptional regulator
S100761_00366	COG3689	TIGRFAM TIGR03943 family protein
S100761_00367	COG0701	Predicted permease
S100761_00368	COG2267	carboxylic ester hydrolase activity
S100761_00369	COG0492	ferredoxin-NADP+ reductase activity
S100761_00370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100761_00370	COG1587	Uroporphyrinogen-III synthase
S100761_00371	COG2146	nitrite reductase [NAD(P)H] activity
S100761_00372	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100761_00373	COG0243	molybdopterin cofactor binding
S100761_00374	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100761_00375	COG2223	nitrite transmembrane transporter activity
S100761_00376	COG1469	GTP cyclohydrolase I activity
S100761_00377	COG1376	ErfK ybiS ycfS ynhG family protein
S100761_00378	COG0523	cobalamin synthesis protein
S100761_00379	COG0765	amino acid transport
S100761_00380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100761_00382	COG1714	RDD family
S100761_00384	COG1846	Transcriptional regulator
S100761_00386	COG3842	ATPase activity
S100761_00387	COG2723	6-phospho-beta-galactosidase activity
S100761_00389	COG3209	COG3209 Rhs family protein
S100761_00390	COG3290	protein histidine kinase activity
S100761_00390	COG0840	transmembrane signaling receptor activity
S100761_00391	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S100761_00392	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
S100761_00393	COG1733	regulation of RNA biosynthetic process
S100761_00394	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100761_00395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100761_00396	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100761_00397	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S100761_00398	COG2814	Major facilitator Superfamily
S100761_00400	COG0697	spore germination
S100761_00401	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100761_00403	COG2364	Membrane
S100761_00404	COG1126	abc transporter atp-binding protein
S100761_00405	COG0765	amino acid transport
S100761_00406	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100761_00407	COG0583	DNA-binding transcription factor activity
S100761_00408	COG0163	prenyltransferase activity
S100761_00409	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S100761_00412	COG0596	Alpha beta hydrolase
S100761_00413	COG3104	oligopeptide transport
S100761_00414	COG5434	Belongs to the glycosyl hydrolase 28 family
S100761_00416	COG0697	spore germination
S100761_00418	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S100761_00419	COG1136	(ABC) transporter
S100761_00420	COG0577	efflux transmembrane transporter activity
S100761_00421	COG0745	RESPONSE REGULATOR receiver
S100761_00422	COG5002	protein histidine kinase activity
S100761_00422	COG3850	Histidine kinase
S100761_00423	COG0457	Tetratricopeptide repeat
S100761_00426	COG0527	aspartate kinase activity
S100761_00427	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_00428	COG4605	iron ion homeostasis
S100761_00429	COG4604	ABC transporter, ATP-binding protein
S100761_00430	COG4607	ABC-type enterochelin transport system periplasmic component
S100761_00432	COG2814	Major facilitator Superfamily
S100761_00433	COG1309	transcriptional regulator
S100761_00434	COG0778	Nitroreductase
S100761_00435	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100761_00436	COG0640	Transcriptional regulator
S100761_00437	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100761_00438	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S100761_00439	COG1012	belongs to the aldehyde dehydrogenase family
S100761_00440	COG4975	Glucose uptake
S100761_00441	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_00442	COG4549	nuclear export factor GLE1
S100761_00443	COG2372	response to copper ion
S100761_00443	COG1276	copper resistance
S100761_00444	COG1349	DNA-binding transcription factor activity
S100761_00446	COG2213	PTS system mannitol-specific
S100761_00447	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_00448	COG0246	Mannitol dehydrogenase
S100761_00449	COG0473	3-isopropylmalate dehydrogenase activity
S100761_00451	COG0681	Belongs to the peptidase S26 family
S100761_00452	COG0412	Dienelactone hydrolase
S100761_00453	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100761_00455	COG0561	phosphatase activity
S100761_00456	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S100761_00457	COG1914	H( )-stimulated, divalent metal cation uptake system
S100761_00458	COG4336	lyase activity
S100761_00459	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S100761_00460	COG1984	allophanate hydrolase subunit 2
S100761_00461	COG1414	Transcriptional regulator
S100761_00462	COG2755	lipolytic protein G-D-S-L family
S100761_00464	COG2329	Antibiotic biosynthesis monooxygenase
S100761_00465	COG0768	penicillin binding
S100761_00466	COG4989	oxidoreductase activity
S100761_00467	COG3711	transcriptional antiterminator
S100761_00468	COG0318	PFAM AMP-dependent synthetase and ligase
S100761_00469	COG2226	methyltransferase
S100761_00470	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_00471	COG1917	Cupin 2, conserved barrel domain protein
S100761_00472	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_00473	COG3871	stress protein (general stress protein 26)
S100761_00475	COG2814	Major facilitator Superfamily
S100761_00476	COG1522	sequence-specific DNA binding
S100761_00477	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100761_00477	COG0551	DNA topoisomerase type I activity
S100761_00478	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
S100761_00479	COG3706	GGDEF domain
S100761_00480	COG5298	Protein conserved in bacteria
S100761_00481	COG1215	transferase activity, transferring glycosyl groups
S100761_00484	COG0531	amino acid
S100761_00485	COG0494	nUDIX hydrolase
S100761_00486	COG0028	Belongs to the TPP enzyme family
S100761_00492	COG1914	H( )-stimulated, divalent metal cation uptake system
S100761_00493	COG2261	transglycosylase associated protein
S100761_00494	COG4876	unkown
S100761_00495	COG2217	Heavy metal translocating P-type atpase
S100761_00496	COG3729	General stress protein
S100761_00497	COG0662	Cupin 2, conserved barrel domain protein
S100761_00498	COG2329	Antibiotic biosynthesis monooxygenase
S100761_00499	COG3546	catalase activity
S100761_00500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S100761_00501	COG3290	protein histidine kinase activity
S100761_00502	COG4565	transcriptional regulatory protein
S100761_00503	COG1301	dicarboxylic acid transport
S100761_00504	COG0628	permease
S100761_00506	COG1131	(ABC) transporter
S100761_00507	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100761_00509	COG1960	acyl-CoA dehydrogenase activity
S100761_00512	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100761_00513	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100761_00514	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100761_00515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S100761_00516	COG0513	Belongs to the DEAD box helicase family
S100761_00517	COG3402	PFAM membrane-flanked domain
S100761_00518	COG3428	Bacterial PH domain
S100761_00519	COG0705	Rhomboid family
S100761_00520	COG0736	holo-[acyl-carrier-protein] synthase activity
S100761_00521	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S100761_00522	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100761_00523	COG0864	Transcriptional regulator
S100761_00524	COG2337	Toxic component of a toxin-antitoxin (TA) module
S100761_00525	COG1366	Belongs to the anti-sigma-factor antagonist family
S100761_00526	COG1366	Belongs to the anti-sigma-factor antagonist family
S100761_00527	COG2172	sigma factor antagonist activity
S100761_00528	COG2208	phosphoserine phosphatase activity
S100761_00529	COG1366	Belongs to the anti-sigma-factor antagonist family
S100761_00530	COG2172	sigma factor antagonist activity
S100761_00531	COG1191	sigma factor activity
S100761_00532	COG2208	phosphoserine phosphatase activity
S100761_00533	COG2183	response to ionizing radiation
S100761_00534	COG3091	SprT-like family
S100761_00544	COG0640	Transcriptional regulator
S100761_00545	COG0640	Transcriptional regulator
S100761_00546	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S100761_00547	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100761_00548	COG0582	viral genome integration into host DNA
S100761_00549	COG2856	Zn peptidase
S100761_00550	COG1396	sequence-specific DNA binding
S100761_00555	COG1674	ftsk spoiiie
S100761_00556	COG2946	Replication initiation factor
S100761_00563	COG0433	COG0433 Predicted ATPase
S100761_00565	COG5644	endopeptidase inhibitor activity
S100761_00566	COG0791	NLP P60 protein
S100761_00566	COG0741	lytic transglycosylase activity
S100761_00569	COG0457	Tetratricopeptide repeat
S100761_00573	COG0583	DNA-binding transcription factor activity
S100761_00574	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_00576	COG5444	nuclease activity
S100761_00577	COG1476	TRANSCRIPTIONal
S100761_00582	COG0693	protein deglycase activity
S100761_00583	COG1278	Cold shock
S100761_00584	COG1329	Transcriptional regulator
S100761_00585	COG0697	spore germination
S100761_00586	COG2207	Transcriptional regulator
S100761_00586	COG1917	Cupin 2, conserved barrel domain protein
S100761_00587	COG0697	spore germination
S100761_00588	COG2207	Transcriptional regulator
S100761_00588	COG3708	Transcriptional regulator
S100761_00589	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100761_00590	COG0477	Major facilitator Superfamily
S100761_00591	COG0477	Major facilitator Superfamily
S100761_00593	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
S100761_00596	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_00597	COG1309	transcriptional regulator
S100761_00598	COG0697	spore germination
S100761_00599	COG0697	spore germination
S100761_00600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100761_00601	COG2030	dehydratase
S100761_00602	COG3545	Serine hydrolase
S100761_00603	COG1733	regulation of RNA biosynthetic process
S100761_00604	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100761_00605	COG1733	regulation of RNA biosynthetic process
S100761_00606	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100761_00607	COG2814	Major facilitator Superfamily
S100761_00608	COG1309	transcriptional regulator
S100761_00609	COG0640	Transcriptional regulator
S100761_00610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S100761_00611	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_00612	COG0697	spore germination
S100761_00613	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100761_00614	COG0076	glutamate decarboxylase activity
S100761_00615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100761_00616	COG0640	Transcriptional regulator
S100761_00617	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S100761_00619	COG4585	Histidine kinase
S100761_00620	COG2197	response regulator
S100761_00621	COG2409	Drug exporters of the RND superfamily
S100761_00622	COG1811	Na channel or pump
S100761_00623	COG4978	Transcriptional regulator
S100761_00623	COG0789	Transcriptional regulator
S100761_00624	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100761_00625	COG0778	Nitroreductase
S100761_00626	COG0346	lactoylglutathione lyase activity
S100761_00627	COG2259	Doxx family
S100761_00628	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100761_00632	COG2323	membrane
S100761_00633	COG2323	membrane
S100761_00634	COG0071	Belongs to the small heat shock protein (HSP20) family
S100761_00637	COG1309	transcriptional regulator
S100761_00639	COG0456	acetyltransferase
S100761_00641	COG1113	amino acid transport
S100761_00642	COG2318	DinB family
S100761_00643	COG1846	Transcriptional regulator
S100761_00644	COG1033	growth of symbiont in host cell
S100761_00644	COG2409	Drug exporters of the RND superfamily
S100761_00645	COG0778	Nitroreductase
S100761_00646	COG1846	Transcriptional regulator
S100761_00647	COG2814	Major facilitator Superfamily
S100761_00648	COG0730	response to heat
S100761_00649	COG1802	Transcriptional regulator
S100761_00650	COG1388	LysM domain
S100761_00650	COG3858	chitin binding
S100761_00651	COG1819	glycosyl
S100761_00653	COG1785	Belongs to the alkaline phosphatase family
S100761_00654	COG5646	InterPro IPR014922
S100761_00656	COG0454	-acetyltransferase
S100761_00657	COG1078	dGTPase activity
S100761_00658	COG1388	LysM domain
S100761_00659	COG2814	Major facilitator Superfamily
S100761_00660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100761_00661	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100761_00662	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100761_00663	COG2723	6-phospho-beta-galactosidase activity
S100761_00664	COG2188	Transcriptional regulator
S100761_00665	COG1940	carbohydrate kinase activity
S100761_00666	COG1482	cell wall glycoprotein biosynthetic process
S100761_00667	COG4124	Belongs to the glycosyl hydrolase 26 family
S100761_00676	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S100761_00677	COG0802	atpase or kinase
S100761_00678	COG1214	PFAM Peptidase M22, glycoprotease
S100761_00679	COG0456	acetyltransferase
S100761_00680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S100761_00681	COG0488	(ABC) transporter
S100761_00682	COG0315	cyclic pyranopterin monophosphate synthase activity
S100761_00683	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S100761_00684	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100761_00685	COG0805	protein transport
S100761_00687	COG1266	CAAX protease self-immunity
S100761_00688	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S100761_00689	COG0459	protein refolding
S100761_00690	COG1073	alpha beta
S100761_00691	COG0457	Tetratricopeptide repeat
S100761_00692	COG1063	alcohol dehydrogenase
S100761_00693	COG2211	Major facilitator Superfamily
S100761_00694	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100761_00695	COG1842	Phage shock protein A
S100761_00696	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100761_00697	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S100761_00698	COG4260	virion core protein, lumpy skin disease virus
S100761_00700	COG2814	Major facilitator Superfamily
S100761_00701	COG1063	alcohol dehydrogenase
S100761_00702	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S100761_00703	COG0823	Involved in the tonB-independent uptake of proteins
S100761_00706	COG2267	carboxylic ester hydrolase activity
S100761_00708	COG2132	Multicopper oxidase
S100761_00709	COG1113	amino acid transport
S100761_00710	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100761_00711	COG0714	Associated with various cellular activities
S100761_00712	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S100761_00713	COG1305	Transglutaminase-like
S100761_00714	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S100761_00714	COG0519	Catalyzes the synthesis of GMP from XMP
S100761_00717	COG2252	PERMEase
S100761_00718	COG3064	Membrane
S100761_00720	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S100761_00722	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S100761_00723	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S100761_00724	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S100761_00725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S100761_00726	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100761_00727	COG0047	phosphoribosylformylglycinamidine synthase activity
S100761_00728	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100761_00729	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S100761_00730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S100761_00731	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S100761_00732	COG0138	bifunctional purine biosynthesis protein purh
S100761_00733	COG0151	Belongs to the GarS family
S100761_00734	COG1522	sequence-specific DNA binding
S100761_00735	COG0531	amino acid
S100761_00737	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100761_00738	COG1470	cell adhesion involved in biofilm formation
S100761_00739	COG4496	protein, YerC YecD
S100761_00740	COG0069	glutamate synthase activity
S100761_00741	COG0069	glutamate synthase activity
S100761_00743	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
S100761_00744	COG0210	DNA helicase
S100761_00745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S100761_00746	COG4851	CamS sex pheromone cAM373 precursor
S100761_00747	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100761_00748	COG1285	pathogenesis
S100761_00749	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100761_00750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100761_00751	COG0154	amidase activity
S100761_00752	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100761_00753	COG1309	transcriptional regulator
S100761_00754	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S100761_00755	COG1597	lipid kinase activity
S100761_00756	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100761_00765	COG0457	Tetratricopeptide repeat
S100761_00767	COG0457	Tetratricopeptide repeat
S100761_00771	COG5444	nuclease activity
S100761_00773	COG3586	endonuclease activity
S100761_00775	COG0457	Tetratricopeptide repeat
S100761_00777	COG0217	transcriptional regulatory protein
S100761_00779	COG1309	transcriptional regulator
S100761_00780	COG3631	Ketosteroid isomerase-related protein
S100761_00781	COG0702	epimerase
S100761_00784	COG3546	catalase activity
S100761_00785	COG0454	-acetyltransferase
S100761_00787	COG5578	integral membrane protein
S100761_00788	COG2972	Histidine kinase
S100761_00789	COG4753	response regulator
S100761_00789	COG2207	Transcriptional regulator
S100761_00790	COG1653	transport
S100761_00791	COG1175	transmembrane transport
S100761_00792	COG0395	ABC-type sugar transport system, permease component
S100761_00793	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S100761_00794	COG2207	Transcriptional regulator
S100761_00795	COG2755	lipolytic protein G-D-S-L family
S100761_00797	COG5578	integral membrane protein
S100761_00798	COG3401	FG-GAP repeat protein
S100761_00799	COG3401	FG-GAP repeat protein
S100761_00800	COG2755	lipolytic protein G-D-S-L family
S100761_00801	COG1874	Beta-galactosidase
S100761_00803	COG1653	transport
S100761_00804	COG4209	transmembrane transport
S100761_00805	COG0395	ABC-type sugar transport system, permease component
S100761_00806	COG1486	melibiose metabolic process
S100761_00807	COG2323	membrane
S100761_00808	COG2329	Antibiotic biosynthesis monooxygenase
S100761_00809	COG0346	lactoylglutathione lyase activity
S100761_00811	COG5583	Uncharacterized small protein (DUF2292)
S100761_00812	COG0670	Belongs to the BI1 family
S100761_00813	COG0697	spore germination
S100761_00814	COG1846	Transcriptional regulator
S100761_00815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S100761_00817	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100761_00817	COG2124	cytochrome p450
S100761_00818	COG1368	sulfuric ester hydrolase activity
S100761_00819	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S100761_00820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100761_00821	COG1442	glycosyl transferase family 8
S100761_00822	COG1216	Glycosyl transferase, family 2
S100761_00823	COG1442	glycosyl transferase family 8
S100761_00824	COG2223	nitrite transmembrane transporter activity
S100761_00825	COG1011	Hydrolase
S100761_00826	COG0531	amino acid
S100761_00827	COG1012	belongs to the aldehyde dehydrogenase family
S100761_00828	COG0840	transmembrane signaling receptor activity
S100761_00829	COG0488	(ABC) transporter
S100761_00831	COG0789	Transcriptional regulator
S100761_00832	COG2814	Major facilitator Superfamily
S100761_00834	COG0488	(ABC) transporter
S100761_00835	COG0513	Belongs to the DEAD box helicase family
S100761_00836	COG0456	acetyltransferase
S100761_00837	COG2130	NADP-dependent
S100761_00838	COG1120	ATPase activity
S100761_00839	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_00840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_00841	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S100761_00844	COG3866	Pectate lyase
S100761_00845	COG0471	metal ion transport
S100761_00846	COG3290	protein histidine kinase activity
S100761_00847	COG4565	transcriptional regulatory protein
S100761_00848	COG3181	Tripartite tricarboxylate transporter family receptor
S100761_00849	COG2851	Citrate transporter
S100761_00850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100761_00851	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
S100761_00852	COG1254	Belongs to the acylphosphatase family
S100761_00853	COG2258	MOSC domain
S100761_00857	COG0024	Methionine aminopeptidase
S100761_00858	COG1263	PTS System
S100761_00858	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_00859	COG1263	PTS System
S100761_00859	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_00860	COG1368	sulfuric ester hydrolase activity
S100761_00862	COG1115	amino acid carrier protein
S100761_00863	COG0697	spore germination
S100761_00864	COG1263	PTS System
S100761_00864	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_00865	COG0366	Alpha amylase catalytic
S100761_00866	COG2188	Transcriptional regulator
S100761_00867	COG0778	Nitroreductase
S100761_00868	COG0737	Belongs to the 5'-nucleotidase family
S100761_00869	COG0693	protein deglycase activity
S100761_00870	COG2814	Major facilitator Superfamily
S100761_00871	COG4840	Belongs to the UPF0435 family
S100761_00872	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100761_00873	COG4980	gas vesicle protein
S100761_00874	COG1295	ribonuclease BN
S100761_00876	COG0477	Major facilitator Superfamily
S100761_00877	COG0387	Pfam Sodium calcium exchanger
S100761_00879	COG0668	transmembrane transport
S100761_00880	COG0535	radical SAM domain protein
S100761_00882	COG0726	polysaccharide deacetylase
S100761_00883	COG2084	Dehydrogenase
S100761_00884	COG0598	Magnesium transport protein CorA
S100761_00885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S100761_00886	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100761_00888	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100761_00889	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100761_00890	COG4637	Psort location Cytoplasmic, score
S100761_00892	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100761_00893	COG0022	dehydrogenase e1 component
S100761_00894	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100761_00895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100761_00896	COG3284	Transcriptional regulator
S100761_00898	COG1742	UPF0060 membrane protein
S100761_00903	COG4842	Belongs to the WXG100 family
S100761_00904	COG1486	melibiose metabolic process
S100761_00905	COG1737	Transcriptional regulator
S100761_00906	COG1263	PTS System
S100761_00906	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_00907	COG5434	Belongs to the glycosyl hydrolase 28 family
S100761_00908	COG1132	(ABC) transporter
S100761_00909	COG1132	(ABC) transporter
S100761_00910	COG2259	Doxx family
S100761_00911	COG2514	catechol 2,3-dioxygenase activity
S100761_00912	COG4585	Histidine kinase
S100761_00913	COG2197	response regulator
S100761_00914	COG1131	(ABC) transporter
S100761_00915	COG0842	Transport permease protein
S100761_00915	COG1511	domain protein
S100761_00916	COG0842	Transport permease protein
S100761_00917	COG1695	Transcriptional regulator
S100761_00918	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S100761_00919	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
S100761_00920	COG1309	transcriptional regulator
S100761_00921	COG2814	Major facilitator Superfamily
S100761_00922	COG2318	DinB family
S100761_00923	COG2814	Major facilitator Superfamily
S100761_00924	COG1846	Transcriptional regulator
S100761_00925	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S100761_00925	COG0392	lysyltransferase activity
S100761_00926	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100761_00927	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_00928	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_00929	COG0384	phenazine biosynthesis protein PhzF
S100761_00930	COG0778	Nitroreductase
S100761_00933	COG1090	epimerase
S100761_00934	COG2137	regulation of response to DNA damage stimulus
S100761_00936	COG2814	Major facilitator Superfamily
S100761_00939	COG3103	Sh3 type 3 domain protein
S100761_00940	COG5658	integral membrane protein
S100761_00941	COG0596	Alpha beta hydrolase
S100761_00942	COG0463	Glycosyl transferase, family 2
S100761_00943	COG4485	Bacterial membrane protein, YfhO
S100761_00944	COG1988	membrane-bound metal-dependent
S100761_00945	COG1194	a g-specific adenine glycosylase
S100761_00947	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_00950	COG3557	Belongs to the UPF0374 family
S100761_00951	COG1132	(ABC) transporter
S100761_00952	COG4129	membrane
S100761_00953	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100761_00954	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S100761_00955	COG0735	belongs to the Fur family
S100761_00977	COG4326	sporulation control protein
S100761_00979	COG3340	Belongs to the peptidase S51 family
S100761_00980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S100761_00982	COG0753	catalase activity
S100761_00983	COG1116	anion transmembrane transporter activity
S100761_00984	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100761_00985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100761_00986	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100761_00988	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100761_00990	COG1476	TRANSCRIPTIONal
S100761_00992	COG3382	B3 4 domain protein
S100761_00993	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S100761_00995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S100761_00996	COG0789	Transcriptional regulator
S100761_00997	COG1664	Polymer-forming cytoskeletal
S100761_00998	COG1664	Polymer-forming cytoskeletal
S100761_00999	COG2766	serine protein kinase
S100761_01000	COG2718	Belongs to the UPF0229 family
S100761_01001	COG1846	Transcriptional regulator
S100761_01002	COG1566	PFAM secretion protein HlyD family protein
S100761_01003	COG2814	Major facilitator Superfamily
S100761_01004	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100761_01007	COG1725	Transcriptional regulator
S100761_01008	COG1131	(ABC) transporter
S100761_01009	COG1131	(ABC) transporter
S100761_01010	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100761_01011	COG1278	Cold shock
S100761_01012	COG1464	Belongs to the NlpA lipoprotein family
S100761_01013	COG3706	GGDEF domain
S100761_01014	COG1823	symporter activity
S100761_01015	COG5444	nuclease activity
S100761_01020	COG0582	viral genome integration into host DNA
S100761_01030	COG0433	COG0433 Predicted ATPase
S100761_01032	COG5644	endopeptidase inhibitor activity
S100761_01033	COG0741	lytic transglycosylase activity
S100761_01033	COG0791	NLP P60 protein
S100761_01039	COG0457	Tetratricopeptide repeat
S100761_01044	COG5577	PFAM Coat F domain
S100761_01045	COG4085	toxin activity
S100761_01045	COG1525	nuclease
S100761_01045	COG0737	Belongs to the 5'-nucleotidase family
S100761_01046	COG3764	Sortase (surface protein transpeptidase)
S100761_01047	COG0564	pseudouridine synthase activity
S100761_01049	COG0517	IMP dehydrogenase activity
S100761_01050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100761_01051	COG3153	acetyltransferase
S100761_01051	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100761_01052	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100761_01053	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
S100761_01054	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100761_01055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S100761_01056	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S100761_01057	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100761_01058	COG2203	Gaf domain
S100761_01058	COG4585	Histidine kinase
S100761_01059	COG2197	response regulator
S100761_01060	COG0431	NADPH-dependent FMN reductase
S100761_01063	COG1388	LysM domain
S100761_01063	COG0791	NLP P60 protein
S100761_01064	COG1959	2 iron, 2 sulfur cluster binding
S100761_01065	COG0668	transmembrane transport
S100761_01066	COG2719	SpoVR family
S100761_01067	COG1785	Belongs to the alkaline phosphatase family
S100761_01068	COG0791	NLP P60 protein
S100761_01068	COG1388	LysM domain
S100761_01069	COG0583	DNA-binding transcription factor activity
S100761_01070	COG0372	Belongs to the citrate synthase family
S100761_01071	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_01072	COG0531	amino acid
S100761_01073	COG0733	neurotransmitter:sodium symporter activity
S100761_01074	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100761_01075	COG0456	acetyltransferase
S100761_01078	COG1595	DNA-templated transcription, initiation
S100761_01079	COG0667	Aldo Keto reductase
S100761_01080	COG0204	Acyl-transferase
S100761_01081	COG1253	flavin adenine dinucleotide binding
S100761_01082	COG0789	Transcriptional regulator
S100761_01083	COG0436	Aminotransferase
S100761_01084	COG1253	flavin adenine dinucleotide binding
S100761_01085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100761_01086	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100761_01087	COG0584	glycerophosphoryl diester phosphodiesterase
S100761_01089	COG0668	transmembrane transport
S100761_01090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S100761_01091	COG0726	polysaccharide deacetylase
S100761_01092	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100761_01093	COG1757	Na H antiporter
S100761_01094	COG0589	response to stress
S100761_01095	COG1132	(ABC) transporter
S100761_01096	COG1132	(ABC) transporter
S100761_01097	COG0702	epimerase
S100761_01100	COG0189	ligase activity
S100761_01101	COG0189	ligase activity
S100761_01102	COG4399	Belongs to the UPF0754 family
S100761_01103	COG3679	Belongs to the UPF0342 family
S100761_01104	COG4335	DNA alkylation repair
S100761_01105	COG0561	phosphatase activity
S100761_01106	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100761_01107	COG0475	glutathione-regulated potassium exporter activity
S100761_01108	COG0490	domain, Protein
S100761_01110	COG1024	Enoyl-CoA hydratase
S100761_01112	COG4152	abc transporter atp-binding protein
S100761_01113	COG1668	transmembrane transport
S100761_01114	COG0420	3'-5' exonuclease activity
S100761_01115	COG4717	serine-type aminopeptidase activity
S100761_01116	COG3481	metal-dependent phosphohydrolase, HD sub domain
S100761_01118	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100761_01121	COG1846	Transcriptional regulator
S100761_01122	COG4980	gas vesicle protein
S100761_01125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S100761_01126	COG0537	adenosine 5'-monophosphoramidase activity
S100761_01127	COG1131	(ABC) transporter
S100761_01128	COG4473	ABC transporter
S100761_01130	COG1473	amidohydrolase
S100761_01131	COG3069	C4-dicarboxylate transmembrane transporter activity
S100761_01133	COG2329	Antibiotic biosynthesis monooxygenase
S100761_01134	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100761_01135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S100761_01138	COG1309	transcriptional regulator
S100761_01139	COG1511	domain protein
S100761_01140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100761_01141	COG4377	Putative membrane peptidase family (DUF2324)
S100761_01143	COG1363	Peptidase, m42
S100761_01144	COG4405	Protein conserved in bacteria
S100761_01145	COG1301	dicarboxylic acid transport
S100761_01146	COG1234	tRNA 3'-trailer cleavage
S100761_01147	COG0095	Lipoate-protein ligase
S100761_01148	COG0702	epimerase
S100761_01149	COG0318	PFAM AMP-dependent synthetase and ligase
S100761_01151	COG0501	Belongs to the peptidase M48B family
S100761_01153	COG0456	acetyltransferase
S100761_01154	COG0604	alcohol dehydrogenase
S100761_01155	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S100761_01156	COG0406	alpha-ribazole phosphatase activity
S100761_01157	COG0183	Belongs to the thiolase family
S100761_01158	COG0318	PFAM AMP-dependent synthetase and ligase
S100761_01159	COG1268	BioY protein
S100761_01160	COG0840	transmembrane signaling receptor activity
S100761_01161	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100761_01161	COG0723	plastoquinol--plastocyanin reductase activity
S100761_01162	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_01164	COG4903	ComK protein
S100761_01165	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_01167	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100761_01170	COG0398	Pfam SNARE associated Golgi protein
S100761_01171	COG0681	Belongs to the peptidase S26 family
S100761_01172	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S100761_01173	COG1846	Transcriptional regulator
S100761_01176	COG0738	Major facilitator superfamily
S100761_01177	COG0673	inositol 2-dehydrogenase activity
S100761_01178	COG0561	phosphatase activity
S100761_01179	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100761_01180	COG1609	Transcriptional regulator
S100761_01181	COG3180	Ammonia monooxygenase
S100761_01182	COG0477	Major facilitator Superfamily
S100761_01182	COG2814	Major facilitator Superfamily
S100761_01183	COG4533	DNA binding
S100761_01184	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S100761_01185	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S100761_01186	COG1074	ATP-dependent DNA helicase activity
S100761_01187	COG0420	3'-5' exonuclease activity
S100761_01188	COG0419	ATPase involved in DNA repair
S100761_01189	COG1403	HNH endonuclease
S100761_01197	COG5337	Spore coat protein CotH
S100761_01198	COG0179	Fumarylacetoacetate (FAA) hydrolase
S100761_01200	COG1404	Belongs to the peptidase S8 family
S100761_01202	COG0367	asparagine synthase
S100761_01203	COG2318	DinB family
S100761_01204	COG1562	ergosterol biosynthetic process
S100761_01205	COG0534	Mate efflux family protein
S100761_01206	COG2207	Transcriptional regulator
S100761_01206	COG1917	Cupin 2, conserved barrel domain protein
S100761_01207	COG1609	Transcriptional regulator
S100761_01208	COG0673	inositol 2-dehydrogenase activity
S100761_01209	COG2318	DinB family
S100761_01210	COG1279	arginine transmembrane transporter activity
S100761_01211	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100761_01212	COG1357	PFAM Pentapeptide repeats (8 copies)
S100761_01213	COG2267	carboxylic ester hydrolase activity
S100761_01214	COG0529	Catalyzes the synthesis of activated sulfate
S100761_01215	COG2046	Belongs to the sulfate adenylyltransferase family
S100761_01216	COG0175	sulfate reduction
S100761_01217	COG2045	Belongs to the ComB family
S100761_01218	COG1809	phosphosulfolactate synthase activity
S100761_01219	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100761_01220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100761_01221	COG4948	Mandelate Racemase Muconate Lactonizing
S100761_01222	COG2814	Major facilitator Superfamily
S100761_01223	COG0454	-acetyltransferase
S100761_01224	COG2153	protein acetylation
S100761_01225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S100761_01225	COG0646	methionine synthase
S100761_01226	COG1666	GTP binding
S100761_01227	COG2996	Protein conserved in bacteria
S100761_01231	COG1695	Transcriptional regulator
S100761_01234	COG3227	Zinc metalloprotease (Elastase)
S100761_01235	COG1307	EDD domain protein, DegV family
S100761_01236	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100761_01240	COG0561	phosphatase activity
S100761_01241	COG1073	alpha beta
S100761_01242	COG2151	metal-sulfur cluster biosynthetic enzyme
S100761_01244	COG0277	FAD linked oxidase domain protein
S100761_01245	COG2271	Major facilitator Superfamily
S100761_01246	COG2271	Major facilitator Superfamily
S100761_01247	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S100761_01250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100761_01251	COG0505	Belongs to the CarA family
S100761_01252	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100761_01253	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100761_01256	COG2267	carboxylic ester hydrolase activity
S100761_01257	COG2267	carboxylic ester hydrolase activity
S100761_01259	COG1744	ABC transporter substrate-binding protein PnrA-like
S100761_01262	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100761_01263	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S100761_01264	COG5504	Zn-dependent protease
S100761_01265	COG0444	Belongs to the ABC transporter superfamily
S100761_01266	COG4608	Belongs to the ABC transporter superfamily
S100761_01268	COG0601	transmembrane transport
S100761_01269	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100761_01271	COG0180	Tryptophanyl-tRNA synthetase
S100761_01272	COG4166	transmembrane transport
S100761_01273	COG0601	transmembrane transport
S100761_01274	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100761_01275	COG0444	Belongs to the ABC transporter superfamily
S100761_01276	COG4608	Belongs to the ABC transporter superfamily
S100761_01277	COG2814	Major facilitator Superfamily
S100761_01278	COG0456	acetyltransferase
S100761_01279	COG1393	Belongs to the ArsC family
S100761_01280	COG0861	Integral membrane protein TerC family
S100761_01281	COG4862	establishment of competence for transformation
S100761_01282	COG4469	Competence protein
S100761_01283	COG1164	Oligoendopeptidase f
S100761_01286	COG2346	COG2346, Truncated hemoglobins
S100761_01287	COG0741	lytic transglycosylase activity
S100761_01288	COG4116	CYTH
S100761_01290	COG2357	RelA SpoT domain protein
S100761_01291	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100761_01292	COG0564	pseudouridine synthase activity
S100761_01293	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S100761_01294	COG0569	domain protein
S100761_01294	COG0475	glutathione-regulated potassium exporter activity
S100761_01295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S100761_01296	COG0352	thiamine-phosphate diphosphorylase activity
S100761_01297	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100761_01298	COG2104	thiamine diphosphate biosynthetic process
S100761_01299	COG2022	thiamine diphosphate biosynthetic process
S100761_01300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100761_01301	COG0351	phosphomethylpyrimidine kinase
S100761_01302	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S100761_01313	COG0210	DNA helicase
S100761_01315	COG2153	protein acetylation
S100761_01316	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100761_01317	COG2382	esterase
S100761_01318	COG0626	cystathionine gamma-synthase activity
S100761_01319	COG0626	cystathionine gamma-synthase activity
S100761_01320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_01321	COG5505	Protein of unknown function (DUF819)
S100761_01325	COG2856	Zn peptidase
S100761_01329	COG1396	sequence-specific DNA binding
S100761_01334	COG2801	Transposase and inactivated derivatives
S100761_01345	COG0457	Tetratricopeptide repeat
S100761_01346	COG5444	nuclease activity
S100761_01361	COG0457	Tetratricopeptide repeat
S100761_01362	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100761_01364	COG3711	transcriptional antiterminator
S100761_01364	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_01365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100761_01365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_01365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100761_01366	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_01366	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100761_01366	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100761_01367	COG1482	cell wall glycoprotein biosynthetic process
S100761_01369	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_01371	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S100761_01374	COG0109	protoheme IX farnesyltransferase activity
S100761_01376	COG0726	polysaccharide deacetylase
S100761_01379	COG5504	Zn-dependent protease
S100761_01380	COG2205	protein histidine kinase activity
S100761_01382	COG3383	formate dehydrogenase (NAD+) activity
S100761_01383	COG2427	Protein of unknown function (DUF1641)
S100761_01385	COG1051	belongs to the nudix hydrolase family
S100761_01387	COG2124	cytochrome p450
S100761_01388	COG1819	glycosyl
S100761_01390	COG1587	Uroporphyrinogen-III synthase
S100761_01391	COG0390	transport system, permease component
S100761_01392	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100761_01393	COG0697	spore germination
S100761_01394	COG4297	protein containing double-stranded beta helix domain
S100761_01396	COG1252	NADH dehydrogenase
S100761_01397	COG1904	glucuronate isomerase
S100761_01398	COG2211	Major facilitator Superfamily
S100761_01399	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S100761_01400	COG1063	alcohol dehydrogenase
S100761_01401	COG1312	Catalyzes the dehydration of D-mannonate
S100761_01402	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_01403	COG2271	Major facilitator Superfamily
S100761_01404	COG1609	Transcriptional regulator
S100761_01405	COG0246	Mannitol dehydrogenase
S100761_01406	COG2721	sulfolactate sulfo-lyase activity
S100761_01407	COG0730	response to heat
S100761_01408	COG2318	DinB family
S100761_01409	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100761_01410	COG0457	Tetratricopeptide repeat
S100761_01412	COG2350	Protein conserved in bacteria
S100761_01413	COG3409	Peptidoglycan-binding domain 1 protein
S100761_01413	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100761_01413	COG1388	LysM domain
S100761_01415	COG4195	phage-related replication protein
S100761_01416	COG3546	catalase activity
S100761_01417	COG2856	Zn peptidase
S100761_01418	COG1396	sequence-specific DNA binding
S100761_01420	COG1522	sequence-specific DNA binding
S100761_01421	COG1484	DNA-dependent DNA replication
S100761_01426	COG1595	DNA-templated transcription, initiation
S100761_01427	COG5484	DNA packaging
S100761_01427	COG3728	DNA packaging
S100761_01428	COG1783	phage Terminase large subunit
S100761_01429	COG5518	Phage portal protein
S100761_01430	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S100761_01431	COG4653	Phage capsid family
S100761_01439	COG3953	SLT domain
S100761_01439	COG3953	SLT domain
S100761_01439	COG5412	phage tail tape measure protein
S100761_01439	COG3953	SLT domain
S100761_01439	COG5412	phage tail tape measure protein
S100761_01439	COG5412	phage tail tape measure protein
S100761_01440	COG1652	LysM domain
S100761_01441	COG4193	domain, Protein
S100761_01443	COG3628	GPW Gp25 family protein
S100761_01444	COG3299	homolog of phage Mu protein gp47
S100761_01445	COG3778	Protein conserved in bacteria
S100761_01453	COG3409	Peptidoglycan-binding domain 1 protein
S100761_01453	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100761_01456	COG0306	phosphate transporter
S100761_01457	COG1392	Phosphate transport regulator
S100761_01458	COG0531	amino acid
S100761_01459	COG0346	lactoylglutathione lyase activity
S100761_01460	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100761_01461	COG0463	Glycosyl transferase, family 2
S100761_01463	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100761_01464	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100761_01465	COG2362	D-Aminopeptidase
S100761_01466	COG0601	transmembrane transport
S100761_01467	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100761_01468	COG0444	Belongs to the ABC transporter superfamily
S100761_01469	COG4166	transmembrane transport
S100761_01471	COG1619	proteins homologs of microcin C7 resistance protein MccF
S100761_01472	COG4948	Mandelate Racemase Muconate Lactonizing
S100761_01473	COG0791	NLP P60 protein
S100761_01474	COG4608	Belongs to the ABC transporter superfamily
S100761_01475	COG2706	6-phosphogluconolactonase activity
S100761_01476	COG1834	amidinotransferase
S100761_01477	COG1607	acyl-coa hydrolase
S100761_01478	COG1017	nitric oxide dioxygenase activity
S100761_01478	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S100761_01480	COG2323	membrane
S100761_01481	COG2318	DinB family
S100761_01482	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_01483	COG2076	Multidrug Resistance protein
S100761_01484	COG2076	Multidrug Resistance protein
S100761_01485	COG0788	formyltetrahydrofolate deformylase activity
S100761_01486	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100761_01487	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S100761_01488	COG1764	response to oxidative stress
S100761_01489	COG1846	Transcriptional regulator
S100761_01490	COG1764	response to oxidative stress
S100761_01491	COG0590	tRNA wobble adenosine to inosine editing
S100761_01492	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100761_01493	COG1404	Belongs to the peptidase S8 family
S100761_01494	COG1366	Belongs to the anti-sigma-factor antagonist family
S100761_01495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100761_01496	COG1122	ATPase activity
S100761_01497	COG4721	ABC-type cobalt transport system, permease component
S100761_01499	COG0745	RESPONSE REGULATOR receiver
S100761_01500	COG5002	protein histidine kinase activity
S100761_01500	COG3850	Histidine kinase
S100761_01501	COG3212	peptidase
S100761_01502	COG3212	peptidase
S100761_01505	COG2239	Acts as a magnesium transporter
S100761_01506	COG0789	Transcriptional regulator
S100761_01509	COG1846	Transcriptional regulator
S100761_01510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100761_01511	COG0726	polysaccharide deacetylase
S100761_01512	COG1408	metallophosphoesterase
S100761_01514	COG0463	Glycosyl transferase, family 2
S100761_01515	COG1793	dna ligase
S100761_01515	COG3285	dna ligase
S100761_01516	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S100761_01517	COG5001	Diguanylate cyclase
S100761_01517	COG3300	MHYT domain
S100761_01518	COG0586	Pfam SNARE associated Golgi protein
S100761_01519	COG0861	Integral membrane protein TerC family
S100761_01520	COG1191	sigma factor activity
S100761_01524	COG0501	Belongs to the peptidase M48B family
S100761_01525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100761_01528	COG3594	Acyltransferase
S100761_01529	COG5002	protein histidine kinase activity
S100761_01530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100761_01532	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S100761_01533	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S100761_01534	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100761_01535	COG0436	Aminotransferase
S100761_01536	COG1850	ribulose-bisphosphate carboxylase activity
S100761_01537	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
S100761_01538	COG0235	Class ii aldolase
S100761_01539	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S100761_01540	COG3339	Conserved Protein
S100761_01543	COG3852	Histidine kinase
S100761_01544	COG1846	Transcriptional regulator
S100761_01545	COG1360	Flagellar Motor Protein
S100761_01546	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100761_01547	COG0542	response to heat
S100761_01548	COG3949	Membrane
S100761_01549	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S100761_01550	COG0720	synthase
S100761_01551	COG0602	queuosine metabolic process
S100761_01552	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S100761_01553	COG1733	regulation of RNA biosynthetic process
S100761_01554	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_01555	COG4974	Belongs to the 'phage' integrase family
S100761_01564	COG3858	chitin binding
S100761_01566	COG4873	Protein conserved in bacteria
S100761_01568	COG3773	Cell wall hydrolase
S100761_01569	COG2244	polysaccharide biosynthetic process
S100761_01570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100761_01571	COG2217	Heavy metal translocating P-type atpase
S100761_01573	COG0006	proline dipeptidase activity
S100761_01574	COG1609	Transcriptional regulator
S100761_01576	COG3711	transcriptional antiterminator
S100761_01577	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_01577	COG1263	PTS System
S100761_01577	COG2190	(PTS) system
S100761_01578	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_01579	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S100761_01581	COG1533	DNA photolyase activity
S100761_01582	COG0456	acetyltransferase
S100761_01583	COG0840	transmembrane signaling receptor activity
S100761_01584	COG2084	Dehydrogenase
S100761_01585	COG2340	Cysteine-rich secretory protein family
S100761_01586	COG0768	penicillin binding
S100761_01587	COG4191	Histidine kinase
S100761_01588	COG0436	Aminotransferase
S100761_01590	COG0784	Response regulator, receiver
S100761_01590	COG0835	chemotaxis
S100761_01592	COG2814	Major facilitator Superfamily
S100761_01593	COG1376	ErfK ybiS ycfS ynhG family protein
S100761_01594	COG1408	metallophosphoesterase
S100761_01595	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_01596	COG2200	EAL domain
S100761_01597	COG4703	Protein of unknown function (DUF1797)
S100761_01598	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
S100761_01600	COG0517	IMP dehydrogenase activity
S100761_01601	COG0583	DNA-binding transcription factor activity
S100761_01602	COG0716	FMN binding
S100761_01604	COG0716	FMN binding
S100761_01605	COG2171	N-acyltransferase activity
S100761_01606	COG1473	amidohydrolase
S100761_01608	COG0668	transmembrane transport
S100761_01609	COG0450	alkyl hydroperoxide reductase
S100761_01610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100761_01613	COG0746	molybdenum cofactor guanylyltransferase activity
S100761_01614	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100761_01615	COG0303	'Molybdopterin
S100761_01616	COG1763	Mo-molybdopterin cofactor biosynthetic process
S100761_01617	COG0314	molybdopterin synthase activity
S100761_01618	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S100761_01619	COG1132	(ABC) transporter
S100761_01620	COG1132	(ABC) transporter
S100761_01622	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S100761_01623	COG1136	(ABC) transporter
S100761_01624	COG0577	efflux transmembrane transporter activity
S100761_01625	COG1349	DNA-binding transcription factor activity
S100761_01626	COG1105	Belongs to the carbohydrate kinase PfkB family
S100761_01627	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_01627	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100761_01627	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100761_01628	COG0681	Belongs to the peptidase S26 family
S100761_01630	COG0488	(ABC) transporter
S100761_01631	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100761_01632	COG2309	aminopeptidase activity
S100761_01634	COG1077	Cell shape determining protein MreB Mrl
S100761_01635	COG2002	toxin-antitoxin pair type II binding
S100761_01636	COG3852	Histidine kinase
S100761_01637	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
S100761_01637	COG2105	PFAM AIG2 family protein
S100761_01638	COG0569	domain protein
S100761_01639	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100761_01640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100761_01642	COG0561	phosphatase activity
S100761_01643	COG0242	peptide deformylase activity
S100761_01645	COG0497	DNA recombination
S100761_01646	COG0497	DNA recombination
S100761_01647	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100761_01648	COG0022	dehydrogenase e1 component
S100761_01649	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100761_01650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100761_01651	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100761_01653	COG1982	Orn Lys Arg decarboxylase major
S100761_01654	COG4476	Belongs to the UPF0223 family
S100761_01655	COG4493	Belongs to the UPF0637 family
S100761_01657	COG0483	inositol monophosphate 1-phosphatase activity
S100761_01659	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S100761_01663	COG1595	DNA-templated transcription, initiation
S100761_01669	COG4896	Protein conserved in bacteria
S100761_01671	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S100761_01672	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100761_01673	COG2066	Belongs to the glutaminase family
S100761_01674	COG4838	Belongs to the UPF0358 family
S100761_01675	COG0772	Belongs to the SEDS family
S100761_01676	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S100761_01677	COG1612	heme a metabolic process
S100761_01678	COG0109	protoheme IX farnesyltransferase activity
S100761_01679	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S100761_01679	COG2010	Cytochrome c
S100761_01680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S100761_01681	COG1845	cytochrome c oxidase, subunit III
S100761_01682	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100761_01683	COG3336	cytochrome c oxidase
S100761_01685	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S100761_01686	COG2340	Cysteine-rich secretory protein family
S100761_01689	COG3679	Belongs to the UPF0342 family
S100761_01690	COG4471	UPF0298 protein
S100761_01691	COG0742	ribosomal rna small subunit methyltransferase
S100761_01692	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S100761_01693	COG3314	Sporulation integral membrane protein YlbJ
S100761_01694	COG1752	Esterase of the alpha-beta hydrolase superfamily
S100761_01695	COG3480	Lon protease (S16) C-terminal proteolytic domain
S100761_01696	COG1323	Belongs to the UPF0348 family
S100761_01698	COG1399	metal-binding, possibly nucleic acid-binding protein
S100761_01699	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S100761_01701	COG0454	-acetyltransferase
S100761_01702	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100761_01703	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
S100761_01704	COG2001	Belongs to the MraZ family
S100761_01705	COG0275	rRNA processing
S100761_01706	COG4839	cell division protein FtsL
S100761_01708	COG0768	penicillin binding
S100761_01709	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S100761_01710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100761_01711	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100761_01712	COG0772	Belongs to the SEDS family
S100761_01713	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100761_01714	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S100761_01715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S100761_01716	COG3879	Bacterial protein of unknown function (DUF881)
S100761_01717	COG3879	Bacterial protein of unknown function (DUF881)
S100761_01718	COG3856	small basic protein
S100761_01719	COG0849	cell division
S100761_01720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S100761_01721	COG4412	M6 family metalloprotease domain protein
S100761_01721	COG1404	Belongs to the peptidase S8 family
S100761_01724	COG1191	sigma factor activity
S100761_01725	COG1191	sigma factor activity
S100761_01726	COG1119	ATPase activity
S100761_01727	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100761_01728	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100761_01729	COG1873	PFAM PRC-barrel domain
S100761_01731	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S100761_01732	COG1799	cell septum assembly
S100761_01733	COG0762	integral membrane protein
S100761_01734	COG2302	S4 RNA-binding domain
S100761_01735	COG3599	regulation of cell shape
S100761_01736	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S100761_01737	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100761_01738	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S100761_01739	COG0564	pseudouridine synthase activity
S100761_01740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S100761_01741	COG2233	PERMEase
S100761_01742	COG0540	Belongs to the ATCase OTCase family
S100761_01743	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100761_01744	COG0505	Belongs to the CarA family
S100761_01745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100761_01746	COG0543	2 iron, 2 sulfur cluster binding
S100761_01747	COG0167	dihydroorotate dehydrogenase activity
S100761_01748	COG0284	orotidine-5'-phosphate decarboxylase activity
S100761_01749	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S100761_01750	COG0175	sulfate reduction
S100761_01751	COG0306	phosphate transporter
S100761_01752	COG2046	Belongs to the sulfate adenylyltransferase family
S100761_01753	COG0529	Catalyzes the synthesis of activated sulfate
S100761_01754	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100761_01755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100761_01756	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S100761_01757	COG1648	precorrin-2 dehydrogenase activity
S100761_01759	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100761_01760	COG1561	YicC-like family, N-terminal region
S100761_01761	COG2052	Domain of unknown function (DUF370)
S100761_01762	COG0194	GDP metabolic process
S100761_01763	COG1758	RNA polymerase activity
S100761_01764	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100761_01765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100761_01766	COG0242	peptide deformylase activity
S100761_01767	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S100761_01768	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100761_01768	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S100761_01769	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S100761_01770	COG0631	protein serine/threonine phosphatase activity
S100761_01771	COG0515	serine threonine protein kinase
S100761_01771	COG2815	serine threonine protein kinase
S100761_01772	COG1162	GTPase activity
S100761_01773	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S100761_01774	COG1564	THIamine pyrophosphokinase
S100761_01775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S100761_01776	COG1302	Protein conserved in bacteria
S100761_01777	COG1461	Dihydroxyacetone kinase
S100761_01778	COG1760	l-serine dehydratase
S100761_01779	COG1760	l-serine dehydratase
S100761_01780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S100761_01781	COG1349	DNA-binding transcription factor activity
S100761_01781	COG2050	protein possibly involved in aromatic compounds catabolism
S100761_01782	COG0416	fatty acid biosynthetic process
S100761_01783	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S100761_01784	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_01785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100761_01786	COG0571	ribonuclease III activity
S100761_01787	COG1196	nuclear chromosome segregation
S100761_01788	COG0552	protein localization to endoplasmic reticulum
S100761_01790	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S100761_01791	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S100761_01792	COG0228	four-way junction DNA binding
S100761_01793	COG1837	Belongs to the UPF0109 family
S100761_01795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S100761_01796	COG0336	Belongs to the RNA methyltransferase TrmD family
S100761_01797	COG0335	large ribosomal subunit rRNA binding
S100761_01798	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100761_01799	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100761_01801	COG2257	FlhB HrpN YscU SpaS Family
S100761_01802	COG0045	succinate-CoA ligase (ADP-forming) activity
S100761_01803	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S100761_01804	COG0758	DNA mediated transformation
S100761_01805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100761_01806	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S100761_01807	COG4974	Belongs to the 'phage' integrase family
S100761_01808	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S100761_01809	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S100761_01810	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100761_01811	COG1815	bacterial-type flagellum-dependent cell motility
S100761_01812	COG1558	bacterial-type flagellum-dependent cell motility
S100761_01813	COG1677	Flagellar hook-basal body complex protein FliE
S100761_01814	COG1766	The M ring may be actively involved in energy transduction
S100761_01815	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100761_01816	COG1317	bacterial-type flagellum organization
S100761_01817	COG1157	protein secretion by the type III secretion system
S100761_01818	COG2882	bacterial-type flagellum organization
S100761_01819	COG3334	PFAM MgtE intracellular
S100761_01820	COG3334	PFAM MgtE intracellular
S100761_01821	COG3144	bacterial-type flagellum assembly
S100761_01822	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S100761_01823	COG4786	Flagellar basal body rod
S100761_01824	COG1580	Controls the rotational direction of flagella during chemotaxis
S100761_01825	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100761_01826	COG1776	CheC inhibitor of MCP methylation
S100761_01826	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100761_01827	COG2201	protein-glutamate methylesterase activity
S100761_01828	COG3190	flagellar
S100761_01829	COG1338	Plays a role in the flagellum-specific transport system
S100761_01830	COG1987	bacterial-type flagellum assembly
S100761_01831	COG1684	flagellar biosynthetic protein fliR
S100761_01832	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100761_01833	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100761_01834	COG1419	protein localization to endoplasmic reticulum
S100761_01835	COG0455	bacterial-type flagellum organization
S100761_01836	COG2201	protein-glutamate methylesterase activity
S100761_01837	COG0643	Histidine kinase
S100761_01837	COG2198	Histidine kinase
S100761_01838	COG0835	chemotaxis
S100761_01839	COG1776	CheC inhibitor of MCP methylation
S100761_01840	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S100761_01841	COG1191	sigma factor activity
S100761_01843	COG0052	Belongs to the universal ribosomal protein uS2 family
S100761_01844	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S100761_01845	COG0528	UMP kinase activity
S100761_01846	COG0233	cytoplasmic translational termination
S100761_01847	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S100761_01848	COG4589	Belongs to the CDS family
S100761_01849	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S100761_01850	COG0750	zinc metalloprotease
S100761_01851	COG0442	prolyl-tRNA aminoacylation
S100761_01852	COG2176	DNA-directed DNA polymerase activity
S100761_01853	COG0779	Required for maturation of 30S ribosomal subunits
S100761_01854	COG0195	Participates in both transcription termination and antitermination
S100761_01855	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S100761_01856	COG1358	cellular component organization or biogenesis
S100761_01857	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S100761_01858	COG1550	Protein conserved in bacteria
S100761_01859	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S100761_01860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S100761_01861	COG0196	riboflavin kinase activity
S100761_01862	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S100761_01863	COG1185	polyribonucleotide nucleotidyltransferase activity
S100761_01864	COG0726	polysaccharide deacetylase
S100761_01865	COG0612	Peptidase, M16
S100761_01866	COG1873	PFAM PRC-barrel domain
S100761_01867	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100761_01868	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100761_01869	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S100761_01870	COG0527	aspartate kinase activity
S100761_01871	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100761_01872	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100761_01873	COG0740	serine-type endopeptidase activity
S100761_01875	COG1674	ftsk spoiiie
S100761_01875	COG4980	gas vesicle protein
S100761_01876	COG2188	Transcriptional regulator
S100761_01877	COG2814	Major facilitator Superfamily
S100761_01878	COG0612	Peptidase, M16
S100761_01879	COG0612	Peptidase, M16
S100761_01880	COG0300	oxidoreductase activity
S100761_01883	COG1426	Protein conserved in bacteria
S100761_01884	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S100761_01885	COG1058	Belongs to the CinA family
S100761_01885	COG1546	Belongs to the CinA family
S100761_01886	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S100761_01887	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100761_01888	COG1418	mRNA catabolic process
S100761_01889	COG1692	metallophosphoesterase
S100761_01890	COG2359	stage V sporulation protein S
S100761_01891	COG1063	alcohol dehydrogenase
S100761_01892	COG0156	8-amino-7-oxononanoate synthase activity
S100761_01893	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100761_01894	COG4550	Control of competence regulator ComK, YlbF/YmcA
S100761_01896	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S100761_01897	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S100761_01903	COG0582	viral genome integration into host DNA
S100761_01913	COG3226	Transcriptional regulator
S100761_01915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100761_01916	COG1404	Belongs to the peptidase S8 family
S100761_01917	COG4195	phage-related replication protein
S100761_01918	COG1764	response to oxidative stress
S100761_01919	COG2076	Multidrug Resistance protein
S100761_01920	COG2076	Multidrug Resistance protein
S100761_01923	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S100761_01924	COG1923	regulation of RNA biosynthetic process
S100761_01927	COG1780	Probably involved in ribonucleotide reductase function
S100761_01928	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100761_01929	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100761_01930	COG4112	unkown
S100761_01931	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100761_01932	COG0464	growth
S100761_01933	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S100761_01934	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S100761_01935	COG0789	Transcriptional regulator
S100761_01936	COG0174	glutamine synthetase
S100761_01940	COG4282	regulation of fungal-type cell wall biogenesis
S100761_01943	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_01947	COG3655	Transcriptional regulator
S100761_01951	COG0135	phosphoribosylanthranilate isomerase activity
S100761_01952	COG2211	Major facilitator Superfamily
S100761_01953	COG3507	Belongs to the glycosyl hydrolase 43 family
S100761_01954	COG1940	carbohydrate kinase activity
S100761_01955	COG2115	Belongs to the xylose isomerase family
S100761_01956	COG1070	Carbohydrate kinase
S100761_01957	COG1525	nuclease
S100761_01958	COG2814	Major facilitator Superfamily
S100761_01959	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100761_01961	COG0756	dUTP diphosphatase activity
S100761_01970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100761_01972	COG3832	glyoxalase III activity
S100761_01975	COG0697	spore germination
S100761_01976	COG0697	spore germination
S100761_01983	COG4195	phage-related replication protein
S100761_01985	COG0346	lactoylglutathione lyase activity
S100761_01986	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S100761_01987	COG1388	LysM domain
S100761_01988	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S100761_01989	COG4224	UPF0291 protein
S100761_01990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S100761_01992	COG3763	UPF0154 protein
S100761_01994	COG0785	Cytochrome C biogenesis protein
S100761_01995	COG2201	protein-glutamate methylesterase activity
S100761_01996	COG4846	Membrane protein involved in cytochrome C biogenesis
S100761_01998	COG0071	Belongs to the small heat shock protein (HSP20) family
S100761_02001	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S100761_02002	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100761_02006	COG0824	Thioesterase
S100761_02008	COG4841	protein insertion into membrane
S100761_02009	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S100761_02010	COG1832	CoA-binding protein
S100761_02011	COG0187	DNA topoisomerase II activity
S100761_02012	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100761_02015	COG1115	amino acid carrier protein
S100761_02016	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
S100761_02018	COG5520	Belongs to the glycosyl hydrolase 30 family
S100761_02019	COG3507	Belongs to the glycosyl hydrolase 43 family
S100761_02020	COG3507	Belongs to the glycosyl hydrolase 43 family
S100761_02021	COG2246	polysaccharide biosynthetic process
S100761_02022	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100761_02023	COG0586	Pfam SNARE associated Golgi protein
S100761_02024	COG2404	hydrolase activity, acting on ester bonds
S100761_02025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100761_02026	COG1024	Enoyl-CoA hydratase
S100761_02027	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100761_02028	COG0511	ligase activity, forming carbon-carbon bonds
S100761_02029	COG0439	Biotin carboxylase
S100761_02030	COG0318	PFAM AMP-dependent synthetase and ligase
S100761_02031	COG1960	acyl-CoA dehydrogenase activity
S100761_02032	COG1649	PFAM Uncharacterised BCR, COG1649
S100761_02034	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100761_02034	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
S100761_02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100761_02036	COG2027	D-alanyl-D-alanine carboxypeptidase
S100761_02037	COG2017	converts alpha-aldose to the beta-anomer
S100761_02038	COG0534	Mate efflux family protein
S100761_02041	COG0582	viral genome integration into host DNA
S100761_02042	COG0166	Belongs to the GPI family
S100761_02043	COG0405	Gamma-glutamyltransferase
S100761_02044	COG0583	DNA-binding transcription factor activity
S100761_02045	COG0604	alcohol dehydrogenase
S100761_02046	COG0493	'glutamate synthase
S100761_02047	COG0069	glutamate synthase activity
S100761_02047	COG0067	glutamate synthase
S100761_02047	COG0070	glutamate synthase
S100761_02048	COG0583	DNA-binding transcription factor activity
S100761_02049	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100761_02050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100761_02052	COG0300	oxidoreductase activity
S100761_02053	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S100761_02055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_02056	COG2814	Major facilitator Superfamily
S100761_02057	COG1070	Carbohydrate kinase
S100761_02058	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S100761_02059	COG0243	molybdopterin cofactor binding
S100761_02061	COG2814	Major facilitator Superfamily
S100761_02062	COG0673	inositol 2-dehydrogenase activity
S100761_02063	COG1082	Xylose isomerase domain protein TIM barrel
S100761_02064	COG1609	Transcriptional regulator
S100761_02068	COG0840	transmembrane signaling receptor activity
S100761_02068	COG5278	phosphoserine phosphatase activity
S100761_02069	COG2368	4-hydroxyphenylacetate
S100761_02070	COG4305	rare lipoprotein A
S100761_02071	COG4305	rare lipoprotein A
S100761_02072	COG3619	membrane
S100761_02073	COG3866	Pectate lyase
S100761_02074	COG2135	peptidase activity
S100761_02077	COG2140	Oxalate decarboxylase
S100761_02081	COG2720	vancomycin resistance protein
S100761_02083	COG3655	Transcriptional regulator
S100761_02084	COG3739	integral membrane protein
S100761_02085	COG0583	DNA-binding transcription factor activity
S100761_02086	COG0697	spore germination
S100761_02088	COG0693	protein deglycase activity
S100761_02089	COG2367	Beta-lactamase
S100761_02092	COG0574	Belongs to the PEP-utilizing enzyme family
S100761_02092	COG3848	Pyruvate phosphate dikinase
S100761_02093	COG0574	Belongs to the PEP-utilizing enzyme family
S100761_02093	COG3848	Pyruvate phosphate dikinase
S100761_02094	COG0726	polysaccharide deacetylase
S100761_02095	COG2314	TM2 domain
S100761_02108	COG3655	Transcriptional regulator
S100761_02116	COG0457	Tetratricopeptide repeat
S100761_02118	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_02120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100761_02121	COG2226	methyltransferase
S100761_02122	COG2211	Major facilitator Superfamily
S100761_02123	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100761_02127	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_02128	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100761_02132	COG5444	nuclease activity
S100761_02133	COG4282	regulation of fungal-type cell wall biogenesis
S100761_02134	COG1231	oxidoreductase activity
S100761_02135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100761_02136	COG2207	Transcriptional regulator
S100761_02136	COG0662	Cupin 2, conserved barrel domain protein
S100761_02137	COG0456	acetyltransferase
S100761_02138	COG1309	transcriptional regulator
S100761_02139	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100761_02140	COG3708	Transcriptional regulator
S100761_02141	COG2378	regulation of single-species biofilm formation
S100761_02143	COG0640	Transcriptional regulator
S100761_02144	COG0741	lytic transglycosylase activity
S100761_02145	COG2322	membrane
S100761_02148	COG1619	proteins homologs of microcin C7 resistance protein MccF
S100761_02149	COG3239	Fatty acid desaturase
S100761_02150	COG4585	Histidine kinase
S100761_02151	COG2197	response regulator
S100761_02153	COG3584	3D domain protein
S100761_02153	COG1388	LysM domain
S100761_02154	COG0514	ATP-dependent DNA helicase (RecQ)
S100761_02155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100761_02156	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100761_02159	COG0071	Belongs to the small heat shock protein (HSP20) family
S100761_02164	COG1012	belongs to the aldehyde dehydrogenase family
S100761_02165	COG1657	PFAM Prenyltransferase squalene oxidase
S100761_02166	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100761_02167	COG0733	neurotransmitter:sodium symporter activity
S100761_02168	COG0385	Bile acid
S100761_02169	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100761_02170	COG0567	Dehydrogenase, E1 component
S100761_02171	COG4548	von Willebrand factor, type A
S100761_02172	COG0714	Associated with various cellular activities
S100761_02173	COG2032	superoxide dismutase activity
S100761_02174	COG0791	NLP P60 protein
S100761_02174	COG1388	LysM domain
S100761_02175	COG1819	glycosyl
S100761_02176	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S100761_02178	COG0534	Mate efflux family protein
S100761_02179	COG1366	Belongs to the anti-sigma-factor antagonist family
S100761_02180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100761_02181	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100761_02183	COG2962	Rard protein
S100761_02186	COG2610	gluconate transmembrane transporter activity
S100761_02187	COG2610	gluconate transmembrane transporter activity
S100761_02188	COG1942	4-Oxalocrotonate Tautomerase
S100761_02189	COG1733	regulation of RNA biosynthetic process
S100761_02190	COG0778	Nitroreductase
S100761_02191	COG0400	carboxylic ester hydrolase activity
S100761_02192	COG0346	lactoylglutathione lyase activity
S100761_02194	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100761_02195	COG3409	Peptidoglycan-binding domain 1 protein
S100761_02195	COG0793	Belongs to the peptidase S41A family
S100761_02196	COG2226	methyltransferase
S100761_02198	COG1876	peptidase activity
S100761_02199	COG0813	purine-nucleoside phosphorylase activity
S100761_02202	COG0671	phosphoesterase, PA-phosphatase related
S100761_02206	COG4479	Belongs to the UPF0346 family
S100761_02208	COG1509	lysine 2,3-aminomutase activity
S100761_02209	COG0456	acetyltransferase
S100761_02210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100761_02211	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S100761_02212	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S100761_02213	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100761_02216	COG0456	acetyltransferase
S100761_02217	COG0463	Glycosyl transferase, family 2
S100761_02220	COG4641	Protein conserved in bacteria
S100761_02221	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
S100761_02222	COG1086	Polysaccharide biosynthesis protein
S100761_02223	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100761_02224	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100761_02225	COG1846	Transcriptional regulator
S100761_02226	COG0534	Mate efflux family protein
S100761_02228	COG4698	Protein conserved in bacteria
S100761_02229	COG2755	lipolytic protein G-D-S-L family
S100761_02230	COG1999	signal sequence binding
S100761_02232	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S100761_02233	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100761_02234	COG1272	protein, Hemolysin III
S100761_02235	COG0204	Acyl-transferase
S100761_02236	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100761_02237	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100761_02239	COG2521	methyltransferase
S100761_02239	COG2136	Putative SAM-dependent methyltransferase
S100761_02241	COG0129	dihydroxy-acid dehydratase activity
S100761_02242	COG1413	lyase activity
S100761_02243	COG1418	mRNA catabolic process
S100761_02244	COG0386	Belongs to the glutathione peroxidase family
S100761_02245	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S100761_02246	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100761_02247	COG1278	Cold shock
S100761_02251	COG0328	RNA-DNA hybrid ribonuclease activity
S100761_02252	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
S100761_02253	COG0328	RNA-DNA hybrid ribonuclease activity
S100761_02255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100761_02258	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100761_02260	COG1755	Isoprenylcysteine carboxyl methyltransferase
S100761_02261	COG3424	synthase
S100761_02262	COG2233	PERMEase
S100761_02263	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100761_02264	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S100761_02266	COG0800	Aldolase
S100761_02267	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100761_02268	COG1609	Transcriptional regulator
S100761_02269	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S100761_02270	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_02271	COG1199	ATP-dependent helicase activity
S100761_02273	COG0116	Belongs to the methyltransferase superfamily
S100761_02275	COG4474	Belongs to the UPF0398 family
S100761_02276	COG3359	exonuclease
S100761_02277	COG1205	dead DEAH box helicase
S100761_02277	COG1111	helicase
S100761_02278	COG2190	(PTS) system
S100761_02279	COG0071	Belongs to the small heat shock protein (HSP20) family
S100761_02286	COG3331	DNA recombination
S100761_02287	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100761_02287	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100761_02289	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S100761_02290	COG3935	DnaD domain protein
S100761_02291	COG0017	Asparaginyl-tRNA synthetase
S100761_02292	COG0436	Aminotransferase
S100761_02293	COG5353	protein conserved in bacteria
S100761_02295	COG1199	ATP-dependent helicase activity
S100761_02295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S100761_02296	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S100761_02297	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S100761_02298	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S100761_02299	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
S100761_02299	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
S100761_02300	COG0617	tRNA 3'-terminal CCA addition
S100761_02301	COG0438	transferase activity, transferring glycosyl groups
S100761_02302	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100761_02303	COG1803	Methylglyoxal synthase
S100761_02304	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S100761_02305	COG1694	Mazg nucleotide pyrophosphohydrolase
S100761_02306	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100761_02308	COG4347	Protein of unknown function (DUF1405)
S100761_02309	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100761_02309	COG2010	Cytochrome c
S100761_02310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100761_02311	COG0723	plastoquinol--plastocyanin reductase activity
S100761_02313	COG5582	Belongs to the UPF0302 family
S100761_02314	COG0457	Tetratricopeptide repeat
S100761_02315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S100761_02316	COG0287	Prephenate dehydrogenase
S100761_02318	COG0159	tryptophan synthase activity
S100761_02319	COG0133	tryptophan synthase activity
S100761_02320	COG0135	phosphoribosylanthranilate isomerase activity
S100761_02322	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100761_02323	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100761_02324	COG4401	Chorismate mutase type I
S100761_02325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S100761_02326	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S100761_02327	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S100761_02328	COG0105	UTP biosynthetic process
S100761_02329	COG0142	geranyltranstransferase activity
S100761_02330	COG2226	methyltransferase
S100761_02331	COG0142	geranyltranstransferase activity
S100761_02333	COG0302	gtp cyclohydrolase
S100761_02334	COG0776	regulation of translation
S100761_02335	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100761_02338	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S100761_02339	COG1160	GTP binding
S100761_02344	COG1304	FMN binding
S100761_02345	COG0539	negative regulation of cytoplasmic translation
S100761_02346	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S100761_02348	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
S100761_02349	COG2959	enzyme of heme biosynthesis
S100761_02350	COG3773	Cell wall hydrolase
S100761_02350	COG3409	Peptidoglycan-binding domain 1 protein
S100761_02351	COG2339	peptidase activity
S100761_02352	COG0492	ferredoxin-NADP+ reductase activity
S100761_02353	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100761_02354	COG4862	establishment of competence for transformation
S100761_02355	COG1408	metallophosphoesterase
S100761_02357	COG1388	LysM domain
S100761_02358	COG1266	CAAX protease self-immunity
S100761_02359	COG0514	ATP-dependent DNA helicase (RecQ)
S100761_02360	COG4955	Helix-turn-helix domain
S100761_02361	COG1141	Ferredoxin
S100761_02362	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S100761_02363	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S100761_02364	COG0710	3-dehydroquinate dehydratase activity
S100761_02366	COG1595	DNA-templated transcription, initiation
S100761_02367	COG5002	protein histidine kinase activity
S100761_02368	COG0745	RESPONSE REGULATOR receiver
S100761_02369	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100761_02370	COG1333	cytochrome c biogenesis protein
S100761_02371	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100761_02372	COG1187	pseudouridine synthase activity
S100761_02373	COG0700	Nucleoside recognition
S100761_02374	COG2715	membrane protein required for spore maturation
S100761_02375	COG1686	Belongs to the peptidase S11 family
S100761_02377	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S100761_02378	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S100761_02379	COG1547	Domain of unknown function (DUF309)
S100761_02380	COG0456	acetyltransferase
S100761_02381	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S100761_02382	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100761_02382	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100761_02383	COG0307	riboflavin synthase, alpha
S100761_02384	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100761_02384	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100761_02386	COG0681	Belongs to the peptidase S26 family
S100761_02387	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
S100761_02389	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100761_02390	COG2433	Pfam Transposase IS66
S100761_02396	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100761_02397	COG4086	secreted protein
S100761_02398	COG0019	diaminopimelate decarboxylase activity
S100761_02399	COG0697	spore germination
S100761_02402	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100761_02406	COG1191	sigma factor activity
S100761_02407	COG2172	sigma factor antagonist activity
S100761_02408	COG1366	Belongs to the anti-sigma-factor antagonist family
S100761_02409	COG1686	Belongs to the peptidase S11 family
S100761_02410	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S100761_02411	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S100761_02412	COG4974	Belongs to the 'phage' integrase family
S100761_02414	COG0735	belongs to the Fur family
S100761_02415	COG1300	Membrane
S100761_02417	COG0281	malic enzyme
S100761_02418	COG1757	Na H antiporter
S100761_02419	COG1027	Aspartate ammonia-lyase
S100761_02420	COG0252	asparaginase activity
S100761_02421	COG1396	sequence-specific DNA binding
S100761_02422	COG1379	DNA repair
S100761_02423	COG0494	nUDIX hydrolase
S100761_02425	COG0667	Aldo Keto reductase
S100761_02427	COG1073	alpha beta
S100761_02429	COG4918	Iron-sulphur cluster biosynthesis
S100761_02430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S100761_02430	COG0456	acetyltransferase
S100761_02431	COG2329	Antibiotic biosynthesis monooxygenase
S100761_02432	COG0456	acetyltransferase
S100761_02434	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100761_02436	COG2211	Major facilitator Superfamily
S100761_02438	COG0346	lactoylglutathione lyase activity
S100761_02439	COG1072	(Pantothenic acid kinase))
S100761_02440	COG3048	D-serine ammonia-lyase activity
S100761_02441	COG0300	oxidoreductase activity
S100761_02442	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100761_02443	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100761_02444	COG4187	Peptidase family M20/M25/M40
S100761_02445	COG1902	pentaerythritol trinitrate reductase activity
S100761_02446	COG0596	Alpha beta hydrolase
S100761_02448	COG1234	tRNA 3'-trailer cleavage
S100761_02449	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S100761_02450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100761_02451	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100761_02453	COG0706	membrane insertase activity
S100761_02454	COG3361	conserved protein (COG2071)
S100761_02455	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100761_02456	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100761_02457	COG0346	lactoylglutathione lyase activity
S100761_02459	COG1376	ErfK ybiS ycfS ynhG family protein
S100761_02460	COG4129	membrane
S100761_02461	COG1126	abc transporter atp-binding protein
S100761_02462	COG0765	amino acid transport
S100761_02463	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100761_02465	COG1597	lipid kinase activity
S100761_02466	COG2814	Major facilitator Superfamily
S100761_02467	COG0789	Transcriptional regulator
S100761_02467	COG4978	Transcriptional regulator
S100761_02468	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100761_02469	COG0022	dehydrogenase e1 component
S100761_02470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100761_02471	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100761_02472	COG3426	butyrate kinase activity
S100761_02473	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100761_02474	COG0280	phosphate acetyltransferase
S100761_02475	COG3290	protein histidine kinase activity
S100761_02475	COG3829	transcription factor binding
S100761_02477	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S100761_02478	COG2079	MmgE PrpD family protein
S100761_02479	COG0372	Belongs to the citrate synthase family
S100761_02480	COG1960	acyl-CoA dehydrogenase activity
S100761_02481	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100761_02482	COG0183	Belongs to the thiolase family
S100761_02483	COG0584	glycerophosphoryl diester phosphodiesterase
S100761_02484	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100761_02487	COG1902	pentaerythritol trinitrate reductase activity
S100761_02489	COG0745	RESPONSE REGULATOR receiver
S100761_02490	COG0750	zinc metalloprotease
S100761_02491	COG0497	DNA recombination
S100761_02492	COG1438	arginine binding
S100761_02493	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S100761_02494	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S100761_02495	COG0142	geranyltranstransferase activity
S100761_02496	COG1722	exodeoxyribonuclease VII activity
S100761_02497	COG1570	exodeoxyribonuclease VII activity
S100761_02498	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S100761_02499	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100761_02500	COG1302	Protein conserved in bacteria
S100761_02501	COG0439	Biotin carboxylase
S100761_02502	COG0511	ligase activity, forming carbon-carbon bonds
S100761_02510	COG3854	ATPases associated with a variety of cellular activities
S100761_02512	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S100761_02513	COG0006	proline dipeptidase activity
S100761_02514	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S100761_02516	COG3872	metal-dependent enzyme
S100761_02518	COG1752	Esterase of the alpha-beta hydrolase superfamily
S100761_02519	COG1321	iron dependent repressor
S100761_02520	COG0095	Lipoate-protein ligase
S100761_02521	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100761_02522	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100761_02523	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100761_02524	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S100761_02525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100761_02528	COG1396	sequence-specific DNA binding
S100761_02530	COG0681	Belongs to the peptidase S26 family
S100761_02535	COG4940	Competence protein ComGF
S100761_02537	COG4970	Tfp pilus assembly protein FimT
S100761_02538	COG4537	Required for transformation and DNA binding
S100761_02539	COG1459	type II secretion system
S100761_02540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S100761_02541	COG0517	IMP dehydrogenase activity
S100761_02542	COG0598	Magnesium transport protein CorA
S100761_02543	COG1253	flavin adenine dinucleotide binding
S100761_02544	COG1366	Belongs to the anti-sigma-factor antagonist family
S100761_02546	COG1393	Belongs to the ArsC family
S100761_02548	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100761_02550	COG0011	TIGRFAM Protein of
S100761_02552	COG2866	Carboxypeptidase
S100761_02553	COG1368	sulfuric ester hydrolase activity
S100761_02554	COG1940	carbohydrate kinase activity
S100761_02555	COG4483	Protein conserved in bacteria
S100761_02556	COG0705	Rhomboid family
S100761_02556	COG0457	Tetratricopeptide repeat
S100761_02558	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S100761_02559	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100761_02560	COG0438	transferase activity, transferring glycosyl groups
S100761_02563	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100761_02564	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100761_02565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100761_02566	COG0581	inorganic phosphate transmembrane transporter activity
S100761_02567	COG0573	inorganic phosphate transmembrane transporter activity
S100761_02568	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S100761_02570	COG0477	Major facilitator Superfamily
S100761_02571	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100761_02572	COG2839	Protein conserved in bacteria
S100761_02573	COG5521	maltodextrose utilization protein MalA
S100761_02574	COG1388	LysM domain
S100761_02575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S100761_02576	COG4709	membrane
S100761_02577	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
S100761_02578	COG0735	belongs to the Fur family
S100761_02579	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100761_02581	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S100761_02582	COG0513	Belongs to the DEAD box helicase family
S100761_02584	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S100761_02585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S100761_02586	COG2384	SAM-dependent methyltransferase
S100761_02587	COG2010	Cytochrome c
S100761_02588	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S100761_02589	COG0358	DNA primase activity
S100761_02590	COG1671	Belongs to the UPF0178 family
S100761_02591	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S100761_02592	COG0517	IMP dehydrogenase activity
S100761_02593	COG0751	glycine-tRNA ligase activity
S100761_02594	COG0752	glycyl-tRNA synthetase alpha subunit
S100761_02595	COG1381	Involved in DNA repair and RecF pathway recombination
S100761_02597	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S100761_02598	COG0295	cytidine deaminase activity
S100761_02599	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S100761_02600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S100761_02601	COG1480	7TM receptor with intracellular HD hydrolase
S100761_02603	COG1702	phosphate starvation-inducible protein PhoH
S100761_02604	COG0561	phosphatase activity
S100761_02607	COG4864	UPF0365 protein
S100761_02608	COG1030	water channel activity
S100761_02609	COG1030	water channel activity
S100761_02610	COG1610	YqeY-like protein
S100761_02611	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S100761_02612	COG1283	sodium-dependent phosphate transmembrane transporter activity
S100761_02613	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100761_02614	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S100761_02615	COG2264	protein methyltransferase activity
S100761_02616	COG0484	heat shock protein binding
S100761_02617	COG0443	Heat shock 70 kDa protein
S100761_02618	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S100761_02619	COG1420	regulation of RNA biosynthetic process
S100761_02620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100761_02621	COG0481	GTPase activity
S100761_02623	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100761_02624	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S100761_02625	COG0268	Binds directly to 16S ribosomal RNA
S100761_02626	COG1466	dna polymerase III delta subunit
S100761_02628	COG2333	competence protein COMEC
S100761_02628	COG0658	competence protein
S100761_02629	COG2131	deaminase
S100761_02630	COG1596	polysaccharide export
S100761_02630	COG1555	photosystem II stabilization
S100761_02631	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100761_02632	COG2226	methyltransferase
S100761_02633	COG0799	negative regulation of ribosome biogenesis
S100761_02634	COG1713	HD superfamily hydrolase involved in NAD metabolism
S100761_02635	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S100761_02636	COG1534	Rna-binding protein
S100761_02637	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S100761_02638	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100761_02639	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S100761_02641	COG2755	lipolytic protein G-D-S-L family
S100761_02642	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100761_02642	COG3409	Peptidoglycan-binding domain 1 protein
S100761_02643	COG0398	Pfam SNARE associated Golgi protein
S100761_02644	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S100761_02646	COG3209	COG3209 Rhs family protein
S100761_02648	COG0114	fumarate hydratase activity
S100761_02649	COG0583	DNA-binding transcription factor activity
S100761_02652	COG0457	Tetratricopeptide repeat
S100761_02653	COG5444	nuclease activity
S100761_02654	COG5444	nuclease activity
S100761_02674	COG4978	Transcriptional regulator
S100761_02674	COG0789	Transcriptional regulator
S100761_02675	COG2814	Major facilitator Superfamily
S100761_02676	COG0456	acetyltransferase
S100761_02677	COG1253	flavin adenine dinucleotide binding
S100761_02679	COG0697	spore germination
S100761_02680	COG0583	DNA-binding transcription factor activity
S100761_02681	COG2072	flavoprotein involved in K transport
S100761_02682	COG1230	cation diffusion facilitator family transporter
S100761_02684	COG1114	Component of the transport system for branched-chain amino acids
S100761_02685	COG1687	branched-chain amino acid
S100761_02686	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
S100761_02687	COG1522	sequence-specific DNA binding
S100761_02688	COG2732	(Barnase) inhibitor
S100761_02689	COG2124	cytochrome p450
S100761_02691	COG1335	isochorismatase
S100761_02694	COG2318	DinB family
S100761_02696	COG2070	2-Nitropropane dioxygenase
S100761_02697	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100761_02700	COG3443	Belongs to the bacterial solute-binding protein 9 family
S100761_02701	COG1595	DNA-templated transcription, initiation
S100761_02702	COG0667	Aldo Keto reductase
S100761_02703	COG2851	Citrate transporter
S100761_02704	COG0583	DNA-binding transcription factor activity
S100761_02705	COG2828	Protein conserved in bacteria
S100761_02706	COG3409	Peptidoglycan-binding domain 1 protein
S100761_02707	COG5566	PFAM Mor transcription activator
S100761_02708	COG0596	Alpha beta hydrolase
S100761_02709	COG4991	sh3 domain protein
S100761_02710	COG4991	sh3 domain protein
S100761_02711	COG0346	lactoylglutathione lyase activity
S100761_02713	COG5577	PFAM Coat F domain
S100761_02714	COG1063	alcohol dehydrogenase
S100761_02716	COG5577	PFAM Coat F domain
S100761_02717	COG0789	Transcriptional regulator
S100761_02719	COG1064	alcohol dehydrogenase
S100761_02720	COG0693	protein deglycase activity
S100761_02721	COG1621	beta-fructofuranosidase activity
S100761_02722	COG3716	PTS system mannose fructose sorbose family IID component
S100761_02723	COG3715	PTS system
S100761_02724	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_02725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_02726	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S100761_02726	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100761_02727	COG1113	amino acid transport
S100761_02728	COG1280	lysine exporter protein (LysE YggA)
S100761_02729	COG1378	Sugar-specific transcriptional regulator TrmB
S100761_02730	COG1595	DNA-templated transcription, initiation
S100761_02732	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S100761_02732	COG2755	lipolytic protein G-D-S-L family
S100761_02734	COG2124	cytochrome p450
S100761_02734	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100761_02735	COG1309	transcriptional regulator
S100761_02736	COG2226	methyltransferase
S100761_02739	COG2116	formate transmembrane transporter activity
S100761_02740	COG5609	conserved protein (DUF2294)
S100761_02741	COG3383	formate dehydrogenase (NAD+) activity
S100761_02742	COG2427	Protein of unknown function (DUF1641)
S100761_02744	COG0626	cystathionine gamma-synthase activity
S100761_02745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100761_02746	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S100761_02747	COG2226	methyltransferase
S100761_02750	COG0768	penicillin binding
S100761_02751	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S100761_02752	COG0572	uridine kinase
S100761_02756	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100761_02757	COG3906	Belongs to the UPF0473 family
S100761_02758	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S100761_02759	COG4472	Bacterial protein of unknown function (DUF965)
S100761_02760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S100761_02761	COG0628	permease
S100761_02762	COG1126	abc transporter atp-binding protein
S100761_02763	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100761_02764	COG0765	amino acid transport
S100761_02765	COG0765	amino acid transport
S100761_02768	COG3881	PFAM PRC-barrel domain
S100761_02769	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S100761_02770	COG0457	Tetratricopeptide repeat
S100761_02771	COG0482	sulfurtransferase activity
S100761_02772	COG1104	cysteine desulfurase activity
S100761_02773	COG1959	2 iron, 2 sulfur cluster binding
S100761_02774	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S100761_02775	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S100761_02776	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S100761_02777	COG0124	histidyl-tRNA synthetase
S100761_02779	COG3103	Sh3 type 3 domain protein
S100761_02779	COG4991	sh3 domain protein
S100761_02779	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100761_02780	COG1490	D-aminoacyl-tRNA deacylase activity
S100761_02781	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S100761_02782	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100761_02783	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S100761_02783	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S100761_02784	COG5416	Lipopolysaccharide assembly protein A domain
S100761_02785	COG0490	domain, Protein
S100761_02786	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100761_02786	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100761_02788	COG2244	polysaccharide biosynthetic process
S100761_02789	COG2323	membrane
S100761_02791	COG1862	Preprotein translocase
S100761_02792	COG0343	queuine tRNA-ribosyltransferase activity
S100761_02793	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S100761_02795	COG2255	four-way junction helicase activity
S100761_02796	COG0632	four-way junction helicase activity
S100761_02798	COG2814	Major facilitator Superfamily
S100761_02799	COG0673	inositol 2-dehydrogenase activity
S100761_02800	COG2112	serine threonine protein kinase
S100761_02804	COG1115	amino acid carrier protein
S100761_02805	COG0217	transcriptional regulatory protein
S100761_02807	COG1388	LysM domain
S100761_02808	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S100761_02809	COG0157	Belongs to the NadC ModD family
S100761_02810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S100761_02811	COG1104	cysteine desulfurase activity
S100761_02812	COG1827	regulation of RNA biosynthetic process
S100761_02813	COG0077	Prephenate dehydratase
S100761_02814	COG4492	Belongs to the UPF0735 family
S100761_02815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S100761_02816	COG3290	protein histidine kinase activity
S100761_02817	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S100761_02818	COG2868	ribosomal protein
S100761_02819	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S100761_02820	COG1994	Peptidase M50
S100761_02821	COG0739	heme binding
S100761_02822	COG2894	cell division
S100761_02823	COG0850	regulation of cytokinetic process
S100761_02824	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S100761_02825	COG1792	Involved in formation and maintenance of cell shape
S100761_02826	COG1077	Cell shape determining protein MreB Mrl
S100761_02827	COG2003	Belongs to the UPF0758 family
S100761_02828	COG0424	maF-like protein
S100761_02830	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S100761_02831	COG0285	dihydrofolate synthase activity
S100761_02832	COG0525	valine-tRNA ligase activity
S100761_02834	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100761_02835	COG1388	LysM domain
S100761_02836	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100761_02837	COG0113	porphobilinogen synthase activity
S100761_02838	COG1587	Uroporphyrinogen-III synthase
S100761_02839	COG0181	hydroxymethylbilane synthase activity
S100761_02840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100761_02841	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S100761_02843	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S100761_02844	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S100761_02845	COG1067	ATP-dependent peptidase activity
S100761_02845	COG0470	DNA polymerase III
S100761_02846	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S100761_02847	COG0544	peptidyl-prolyl cis-trans isomerase activity
S100761_02848	COG1477	protein flavinylation
S100761_02848	COG0457	Tetratricopeptide repeat
S100761_02849	COG0066	3-isopropylmalate dehydratase activity
S100761_02850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S100761_02851	COG0473	3-isopropylmalate dehydrogenase activity
S100761_02852	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100761_02853	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S100761_02854	COG0440	acetolactate synthase activity
S100761_02855	COG0028	Belongs to the TPP enzyme family
S100761_02857	COG0454	-acetyltransferase
S100761_02858	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
S100761_02860	COG0622	Phosphoesterase
S100761_02861	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S100761_02862	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S100761_02863	COG5401	PFAM Sporulation and spore germination
S100761_02864	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100761_02865	COG1846	Transcriptional regulator
S100761_02866	COG2197	response regulator
S100761_02867	COG0824	Thioesterase
S100761_02868	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S100761_02869	COG1053	succinate dehydrogenase
S100761_02870	COG2009	succinate dehydrogenase
S100761_02871	COG1719	4-vinyl reductase, 4VR
S100761_02872	COG0527	aspartate kinase activity
S100761_02873	COG0322	excinuclease ABC activity
S100761_02874	COG3118	belongs to the thioredoxin family
S100761_02875	COG3534	alpha-L-arabinofuranosidase
S100761_02877	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S100761_02878	COG2086	electron transfer activity
S100761_02879	COG1024	Enoyl-CoA hydratase
S100761_02880	COG1309	transcriptional regulator
S100761_02881	COG0318	PFAM AMP-dependent synthetase and ligase
S100761_02882	COG3766	membrane
S100761_02883	COG1193	negative regulation of DNA recombination
S100761_02884	COG1796	DNA polymerase
S100761_02884	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100761_02885	COG1286	toxin biosynthetic process
S100761_02886	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S100761_02887	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100761_02888	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100761_02888	COG0072	phenylalanine-tRNA ligase activity
S100761_02889	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S100761_02890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100761_02892	COG3835	regulator
S100761_02893	COG0277	FAD linked oxidase domain protein
S100761_02894	COG0247	lactate metabolic process
S100761_02895	COG0346	lactoylglutathione lyase activity
S100761_02896	COG1966	Carbon starvation protein
S100761_02897	COG3534	alpha-L-arabinofuranosidase
S100761_02898	COG0395	ABC-type sugar transport system, permease component
S100761_02899	COG1175	transmembrane transport
S100761_02900	COG1653	transport
S100761_02901	COG0371	Dehydrogenase
S100761_02902	COG0647	UMP catabolic process
S100761_02903	COG0235	Class ii aldolase
S100761_02904	COG1069	ribulokinase activity
S100761_02905	COG2160	L-arabinose isomerase activity
S100761_02906	COG3507	Belongs to the glycosyl hydrolase 43 family
S100761_02907	COG1363	Peptidase, m42
S100761_02909	COG3326	Membrane
S100761_02910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S100761_02911	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S100761_02912	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S100761_02914	COG1346	cytolysis
S100761_02915	COG1380	Effector of murein hydrolase LrgA
S100761_02916	COG3279	Response regulator of the LytR AlgR family
S100761_02917	COG3275	phosphorelay sensor kinase activity
S100761_02919	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100761_02922	COG0398	Pfam SNARE associated Golgi protein
S100761_02923	COG1484	DNA-dependent DNA replication
S100761_02924	COG3611	Membrane attachment protein
S100761_02925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S100761_02926	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S100761_02927	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100761_02928	COG1733	regulation of RNA biosynthetic process
S100761_02929	COG1733	regulation of RNA biosynthetic process
S100761_02930	COG2814	Major facilitator Superfamily
S100761_02931	COG0656	L-ascorbic acid biosynthetic process
S100761_02932	COG0237	dephospho-CoA kinase activity
S100761_02933	COG1971	Probably functions as a manganese efflux pump
S100761_02934	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S100761_02935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100761_02935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100761_02936	COG5002	protein histidine kinase activity
S100761_02937	COG0745	RESPONSE REGULATOR receiver
S100761_02938	COG0039	L-malate dehydrogenase activity
S100761_02939	COG0538	isocitrate dehydrogenase activity
S100761_02940	COG0372	Belongs to the citrate synthase family
S100761_02941	COG2707	UPF0756 membrane protein
S100761_02942	COG0628	permease
S100761_02943	COG0628	permease
S100761_02944	COG3030	protein affecting phage T7 exclusion by the F plasmid
S100761_02945	COG0469	pyruvate kinase activity
S100761_02946	COG0205	6-phosphofructokinase activity
S100761_02947	COG0825	malonyl-CoA metabolic process
S100761_02948	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S100761_02949	COG0281	malic enzyme
S100761_02950	COG0587	DNA-directed DNA polymerase activity
S100761_02954	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S100761_02956	COG4109	DRTGG domain
S100761_02957	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S100761_02958	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_02960	COG0165	Argininosuccinate lyase
S100761_02961	COG0137	argininosuccinate synthase activity
S100761_02962	COG0521	Mo-molybdopterin cofactor biosynthetic process
S100761_02963	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100761_02965	COG0827	DNA restriction-modification system
S100761_02966	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S100761_02967	COG3874	Sporulation protein YtfJ
S100761_02969	COG1714	RDD family
S100761_02970	COG0616	signal peptide processing
S100761_02971	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100761_02972	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S100761_02973	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100761_02975	COG0301	tRNA thio-modification
S100761_02976	COG1104	cysteine desulfurase activity
S100761_02977	COG1114	Component of the transport system for branched-chain amino acids
S100761_02978	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S100761_02979	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100761_02980	COG1309	transcriptional regulator
S100761_02981	COG1956	GAF domain-containing protein
S100761_02982	COG2199	diguanylate cyclase activity
S100761_02982	COG2203	Gaf domain
S100761_02983	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S100761_02985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100761_02986	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100761_02987	COG0454	-acetyltransferase
S100761_02988	COG0517	IMP dehydrogenase activity
S100761_02989	COG0123	including yeast histone deacetylase and acetoin utilization protein
S100761_02990	COG1360	Flagellar Motor Protein
S100761_02991	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100761_02992	COG1609	Transcriptional regulator
S100761_02993	COG1605	Chorismate mutase
S100761_02993	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S100761_02994	COG3118	belongs to the thioredoxin family
S100761_02995	COG4980	gas vesicle protein
S100761_02996	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S100761_02997	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S100761_02998	COG1674	ftsk spoiiie
S100761_02999	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100761_03000	COG4848	Belongs to the UPF0354 family
S100761_03001	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100761_03003	COG1363	Peptidase, m42
S100761_03004	COG5584	Small secreted protein
S100761_03005	COG0281	malic enzyme
S100761_03006	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100761_03007	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S100761_03009	COG0510	thiamine kinase activity
S100761_03010	COG1523	belongs to the glycosyl hydrolase 13 family
S100761_03011	COG1597	lipid kinase activity
S100761_03013	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100761_03014	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100761_03015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100761_03016	COG2252	PERMEase
S100761_03017	COG4473	ABC transporter
S100761_03018	COG1131	(ABC) transporter
S100761_03019	COG1349	DNA-binding transcription factor activity
S100761_03020	COG1187	pseudouridine synthase activity
S100761_03021	COG2244	polysaccharide biosynthetic process
S100761_03022	COG2081	HI0933 family
S100761_03023	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S100761_03025	COG5578	integral membrane protein
S100761_03026	COG0673	inositol 2-dehydrogenase activity
S100761_03027	COG1653	transport
S100761_03028	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S100761_03029	COG4209	transmembrane transport
S100761_03030	COG2207	Transcriptional regulator
S100761_03031	COG1653	transport
S100761_03032	COG0395	ABC-type sugar transport system, permease component
S100761_03033	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100761_03034	COG2124	cytochrome p450
S100761_03035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S100761_03037	COG0156	8-amino-7-oxononanoate synthase activity
S100761_03038	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100761_03040	COG1073	alpha beta
S100761_03045	COG1486	melibiose metabolic process
S100761_03046	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100761_03047	COG0495	leucyl-tRNA aminoacylation
S100761_03049	COG2202	Pas domain
S100761_03049	COG1366	Belongs to the anti-sigma-factor antagonist family
S100761_03050	COG2814	Major facilitator Superfamily
S100761_03051	COG2433	Pfam Transposase IS66
S100761_03052	COG0577	efflux transmembrane transporter activity
S100761_03053	COG1136	(ABC) transporter
S100761_03054	COG2205	protein histidine kinase activity
S100761_03055	COG0745	RESPONSE REGULATOR receiver
S100761_03056	COG0577	efflux transmembrane transporter activity
S100761_03057	COG1136	(ABC) transporter
S100761_03060	COG1131	(ABC) transporter
S100761_03061	COG1725	Transcriptional regulator
S100761_03064	COG1242	4 iron, 4 sulfur cluster binding
S100761_03065	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S100761_03067	COG2267	carboxylic ester hydrolase activity
S100761_03068	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S100761_03069	COG1113	amino acid transport
S100761_03070	COG0367	asparagine synthase
S100761_03071	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S100761_03072	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S100761_03074	COG1506	peptidase
S100761_03075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100761_03076	COG1116	anion transmembrane transporter activity
S100761_03077	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100761_03078	COG0494	nUDIX hydrolase
S100761_03079	COG4824	toxin secretion phage lysis holin
S100761_03080	COG0783	Belongs to the Dps family
S100761_03083	COG1854	S-ribosylhomocysteine lyase activity
S100761_03084	COG0288	reversible hydration of carbon dioxide
S100761_03085	COG0254	rRNA binding
S100761_03086	COG1271	oxidase subunit
S100761_03087	COG1294	oxidase, subunit
S100761_03089	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100761_03090	COG1321	iron dependent repressor
S100761_03090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100761_03091	COG1121	(ABC) transporter
S100761_03092	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100761_03093	COG4948	Mandelate Racemase Muconate Lactonizing
S100761_03094	COG0318	PFAM AMP-dependent synthetase and ligase
S100761_03095	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S100761_03096	COG0596	Alpha beta hydrolase
S100761_03097	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
S100761_03098	COG1169	isochorismate synthase
S100761_03099	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100761_03100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100761_03101	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100761_03102	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100761_03103	COG0438	transferase activity, transferring glycosyl groups
S100761_03105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100761_03106	COG0438	transferase activity, transferring glycosyl groups
S100761_03107	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100761_03108	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S100761_03109	COG0058	SHG alpha-glucan phosphorylase activity
S100761_03110	COG0297	glycogen (starch) synthase activity
S100761_03111	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100761_03112	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100761_03113	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S100761_03138	COG3859	Proton-coupled thiamine transporter YuaJ
S100761_03139	COG1247	-acetyltransferase
S100761_03140	COG2268	Band 7 protein
S100761_03141	COG1585	Membrane protein implicated in regulation of membrane protease activity
S100761_03142	COG2318	DinB family
S100761_03144	COG1454	alcohol dehydrogenase
S100761_03146	COG1510	regulation of RNA biosynthetic process
S100761_03148	COG0569	domain protein
S100761_03149	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100761_03150	COG4682	membrane
S100761_03151	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100761_03152	COG0477	Major facilitator Superfamily
S100761_03153	COG5553	Cysteine dioxygenase type I
S100761_03155	COG1968	undecaprenyl-diphosphatase activity
S100761_03156	COG0628	permease
S100761_03157	COG0673	inositol 2-dehydrogenase activity
S100761_03158	COG4806	L-rhamnose isomerase
S100761_03159	COG3254	rhamnose metabolic process
S100761_03160	COG1070	Carbohydrate kinase
S100761_03161	COG1349	DNA-binding transcription factor activity
S100761_03162	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03162	COG3347	Dehydrogenase
S100761_03163	COG0840	transmembrane signaling receptor activity
S100761_03164	COG0840	transmembrane signaling receptor activity
S100761_03165	COG0840	transmembrane signaling receptor activity
S100761_03166	COG0840	transmembrane signaling receptor activity
S100761_03169	COG0432	Pfam Uncharacterised protein family UPF0047
S100761_03170	COG0366	Alpha amylase catalytic
S100761_03171	COG1253	flavin adenine dinucleotide binding
S100761_03172	COG2738	Putative neutral zinc metallopeptidase
S100761_03175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S100761_03178	COG0166	Belongs to the GPI family
S100761_03179	COG1979	alcohol dehydrogenase
S100761_03180	COG1979	alcohol dehydrogenase
S100761_03181	COG2155	Conserved Protein
S100761_03182	COG1098	S1 RNA binding domain
S100761_03183	COG0436	Aminotransferase
S100761_03184	COG1522	sequence-specific DNA binding
S100761_03185	COG2267	carboxylic ester hydrolase activity
S100761_03187	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100761_03188	COG2205	protein histidine kinase activity
S100761_03190	COG5018	Exonuclease
S100761_03192	COG2814	Major facilitator Superfamily
S100761_03193	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100761_03194	COG3011	Protein conserved in bacteria
S100761_03196	COG3290	protein histidine kinase activity
S100761_03197	COG4565	transcriptional regulatory protein
S100761_03202	COG3493	citrate carrier protein
S100761_03204	COG2111	Na H antiporter
S100761_03204	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100761_03205	COG2111	Na H antiporter
S100761_03206	COG1006	Multisubunit Na H antiporter MnhC subunit
S100761_03207	COG0651	ATP synthesis coupled electron transport
S100761_03208	COG1863	multisubunit Na H antiporter MnhE subunit
S100761_03209	COG2212	antiporter activity
S100761_03210	COG1320	monovalent cation:proton antiporter activity
S100761_03211	COG2050	protein possibly involved in aromatic compounds catabolism
S100761_03212	COG2197	response regulator
S100761_03213	COG4585	Histidine kinase
S100761_03215	COG0142	geranyltranstransferase activity
S100761_03219	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S100761_03220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S100761_03221	COG1335	isochorismatase
S100761_03222	COG5506	Protein of unknown function (DUF1694)
S100761_03225	COG0628	permease
S100761_03227	COG1418	mRNA catabolic process
S100761_03228	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03230	COG1511	domain protein
S100761_03231	COG0433	COG0433 Predicted ATPase
S100761_03231	COG1674	ftsk spoiiie
S100761_03232	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100761_03233	COG5417	Belongs to the EsaB family
S100761_03234	COG4842	Belongs to the WXG100 family
S100761_03235	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100761_03235	COG2508	Transcriptional regulator
S100761_03236	COG0686	Belongs to the AlaDH PNT family
S100761_03237	COG5634	Uncharacterized conserved protein (DUF2278)
S100761_03238	COG3251	PFAM MbtH domain protein
S100761_03239	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100761_03240	COG3433	isochorismatase activity
S100761_03240	COG1535	isochorismatase
S100761_03241	COG1021	2,3-dihydroxybenzoate-AMP ligase
S100761_03242	COG1169	isochorismate synthase
S100761_03243	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03244	COG2819	hydrolase of the alpha beta superfamily
S100761_03245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100761_03246	COG1268	BioY protein
S100761_03247	COG2056	Na+-H+ antiporter family
S100761_03248	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S100761_03249	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S100761_03250	COG3584	3D domain protein
S100761_03252	COG1252	NADH dehydrogenase
S100761_03253	COG0492	ferredoxin-NADP+ reductase activity
S100761_03255	COG0516	GMP reductase activity
S100761_03256	COG2808	Putative FMN-binding domain
S100761_03257	COG0456	acetyltransferase
S100761_03259	COG0316	Belongs to the HesB IscA family
S100761_03260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S100761_03261	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100761_03262	COG4844	belongs to the
S100761_03263	COG1252	NADH dehydrogenase
S100761_03264	COG4837	Protein of unknown function (DUF1462)
S100761_03265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S100761_03266	COG0823	Involved in the tonB-independent uptake of proteins
S100761_03266	COG1506	peptidase
S100761_03266	COG4946	Tricorn protease homolog
S100761_03267	COG0083	homoserine kinase activity
S100761_03268	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S100761_03269	COG0460	homoserine dehydrogenase
S100761_03270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100761_03271	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100761_03272	COG0647	UMP catabolic process
S100761_03273	COG2445	Protein of unknown function DUF86
S100761_03274	COG4470	Protein conserved in bacteria
S100761_03276	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S100761_03277	COG0739	heme binding
S100761_03279	COG3377	Domain of unknown function (DUF1805)
S100761_03280	COG0737	Belongs to the 5'-nucleotidase family
S100761_03281	COG0730	response to heat
S100761_03282	COG1801	Protein of unknown function DUF72
S100761_03284	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100761_03285	COG2508	Transcriptional regulator
S100761_03286	COG2233	PERMEase
S100761_03287	COG2233	PERMEase
S100761_03288	COG3195	allantoin biosynthetic process
S100761_03288	COG3648	Uricase
S100761_03289	COG2351	hydroxyisourate hydrolase activity
S100761_03291	COG2080	2 iron, 2 sulfur cluster binding
S100761_03292	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S100761_03293	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S100761_03294	COG2068	MobA-Related Protein
S100761_03295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S100761_03296	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S100761_03297	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100761_03298	COG2356	endonuclease I
S100761_03299	COG3842	ATPase activity
S100761_03300	COG2188	Transcriptional regulator
S100761_03301	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100761_03302	COG0395	ABC-type sugar transport system, permease component
S100761_03303	COG1175	transmembrane transport
S100761_03304	COG1653	transport
S100761_03305	COG2222	sugar isomerase
S100761_03306	COG0322	excinuclease ABC activity
S100761_03307	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100761_03310	COG0346	lactoylglutathione lyase activity
S100761_03311	COG0640	Transcriptional regulator
S100761_03312	COG0719	Fe-S assembly protein
S100761_03313	COG0822	iron-sulfur transferase activity
S100761_03314	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100761_03315	COG0719	Fe-S assembly protein
S100761_03316	COG0396	ATPase activity
S100761_03317	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S100761_03318	COG1464	Belongs to the NlpA lipoprotein family
S100761_03319	COG2011	ABC-type metal ion transport system permease component
S100761_03320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100761_03322	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100761_03323	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100761_03325	COG0509	glycine decarboxylation via glycine cleavage system
S100761_03326	COG1393	Belongs to the ArsC family
S100761_03327	COG1960	acyl-CoA dehydrogenase activity
S100761_03328	COG0183	Belongs to the thiolase family
S100761_03329	COG1024	Enoyl-CoA hydratase
S100761_03329	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100761_03331	COG0506	proline dehydrogenase activity
S100761_03333	COG5577	PFAM Coat F domain
S100761_03334	COG1846	Transcriptional regulator
S100761_03335	COG0477	Major facilitator Superfamily
S100761_03336	COG1942	4-Oxalocrotonate Tautomerase
S100761_03337	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03338	COG0583	DNA-binding transcription factor activity
S100761_03340	COG1120	ATPase activity
S100761_03345	COG1131	(ABC) transporter
S100761_03353	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03354	COG0783	Belongs to the Dps family
S100761_03355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100761_03356	COG0745	RESPONSE REGULATOR receiver
S100761_03357	COG2205	protein histidine kinase activity
S100761_03357	COG2770	Histidine kinase
S100761_03358	COG1309	transcriptional regulator
S100761_03359	COG0114	fumarate hydratase activity
S100761_03361	COG0697	spore germination
S100761_03362	COG0814	amino acid
S100761_03364	COG2197	response regulator
S100761_03365	COG4585	Histidine kinase
S100761_03366	COG4758	membrane
S100761_03367	COG3595	metallopeptidase activity
S100761_03368	COG1842	Phage shock protein A
S100761_03369	COG4758	membrane
S100761_03370	COG2814	Major facilitator Superfamily
S100761_03371	COG2096	Adenosyltransferase
S100761_03372	COG1120	ATPase activity
S100761_03373	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_03374	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100761_03375	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03376	COG3386	PFAM SMP-30 Gluconolaconase
S100761_03377	COG2205	protein histidine kinase activity
S100761_03378	COG0745	RESPONSE REGULATOR receiver
S100761_03380	COG1191	sigma factor activity
S100761_03382	COG2140	Oxalate decarboxylase
S100761_03384	COG0577	efflux transmembrane transporter activity
S100761_03385	COG1136	(ABC) transporter
S100761_03386	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S100761_03387	COG1120	ATPase activity
S100761_03388	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_03389	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100761_03390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100761_03392	COG0531	amino acid
S100761_03394	COG1988	membrane-bound metal-dependent
S100761_03395	COG1368	sulfuric ester hydrolase activity
S100761_03396	COG1910	domain protein
S100761_03397	COG0725	ABC transporter, periplasmic molybdate-binding protein
S100761_03398	COG4149	molybdate abc transporter
S100761_03399	COG0656	L-ascorbic acid biosynthetic process
S100761_03401	COG0025	NhaP-type Na H and K H
S100761_03402	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100761_03403	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100761_03404	COG3973	AAA domain
S100761_03406	COG2860	membrane
S100761_03407	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S100761_03408	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S100761_03409	COG2217	Heavy metal translocating P-type atpase
S100761_03410	COG2217	Heavy metal translocating P-type atpase
S100761_03411	COG2608	mercury ion transmembrane transporter activity
S100761_03412	COG1937	Protein conserved in bacteria
S100761_03413	COG0673	inositol 2-dehydrogenase activity
S100761_03414	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100761_03415	COG1289	transmembrane transporter activity
S100761_03417	COG2076	Multidrug Resistance protein
S100761_03418	COG1309	transcriptional regulator
S100761_03419	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S100761_03421	COG0557	exoribonuclease II activity
S100761_03422	COG1647	Serine aminopeptidase, S33
S100761_03423	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100761_03424	COG0596	Alpha beta hydrolase
S100761_03425	COG1476	TRANSCRIPTIONal
S100761_03426	COG1396	sequence-specific DNA binding
S100761_03427	COG1396	sequence-specific DNA binding
S100761_03428	COG1733	regulation of RNA biosynthetic process
S100761_03429	COG0840	transmembrane signaling receptor activity
S100761_03430	COG1174	glycine betaine transport
S100761_03431	COG1732	Glycine betaine
S100761_03432	COG1174	glycine betaine transport
S100761_03433	COG1125	glycine betaine transport
S100761_03433	COG0517	IMP dehydrogenase activity
S100761_03434	COG1510	regulation of RNA biosynthetic process
S100761_03435	COG1174	glycine betaine transport
S100761_03436	COG1732	Glycine betaine
S100761_03437	COG1174	glycine betaine transport
S100761_03438	COG0517	IMP dehydrogenase activity
S100761_03438	COG1125	glycine betaine transport
S100761_03439	COG1510	regulation of RNA biosynthetic process
S100761_03440	COG2095	MarC family integral membrane protein
S100761_03442	COG3064	Membrane
S100761_03443	COG4640	response to antibiotic
S100761_03444	COG0456	acetyltransferase
S100761_03445	COG0148	phosphopyruvate hydratase activity
S100761_03446	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S100761_03447	COG0149	triose-phosphate isomerase activity
S100761_03448	COG0126	phosphoglycerate kinase activity
S100761_03449	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100761_03450	COG2390	Transcriptional regulator
S100761_03451	COG2814	Major facilitator Superfamily
S100761_03452	COG1609	Transcriptional regulator
S100761_03453	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100761_03454	COG0583	DNA-binding transcription factor activity
S100761_03455	COG0697	spore germination
S100761_03456	COG1113	amino acid transport
S100761_03457	COG3858	chitin binding
S100761_03458	COG1556	Lactate utilization protein
S100761_03459	COG1139	Iron-sulfur cluster binding protein
S100761_03460	COG0247	lactate metabolic process
S100761_03463	COG2197	response regulator
S100761_03464	COG4585	Histidine kinase
S100761_03465	COG0842	Transport permease protein
S100761_03466	COG1131	(ABC) transporter
S100761_03468	COG0596	Alpha beta hydrolase
S100761_03469	COG2208	phosphoserine phosphatase activity
S100761_03470	COG3867	Arabinogalactan endo-beta-1,4-galactanase
S100761_03471	COG1874	Beta-galactosidase
S100761_03472	COG3833	ABC-type maltose transport systems, permease component
S100761_03473	COG1175	transmembrane transport
S100761_03474	COG2182	Extracellular solute-binding protein
S100761_03475	COG1609	Transcriptional regulator
S100761_03476	COG2186	Transcriptional regulator
S100761_03477	COG1620	l-lactate permease
S100761_03478	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S100761_03480	COG5039	Polysaccharide pyruvyl transferase
S100761_03481	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100761_03482	COG0110	maltose O-acetyltransferase activity
S100761_03483	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100761_03484	COG2244	polysaccharide biosynthetic process
S100761_03485	COG1216	Glycosyl transferase, family 2
S100761_03486	COG5039	Polysaccharide pyruvyl transferase
S100761_03487	COG1216	Glycosyl transferase, family 2
S100761_03489	COG0438	transferase activity, transferring glycosyl groups
S100761_03490	COG1215	transferase activity, transferring glycosyl groups
S100761_03491	COG0438	transferase activity, transferring glycosyl groups
S100761_03492	COG1086	Polysaccharide biosynthesis protein
S100761_03493	COG0489	protein tyrosine kinase activity
S100761_03494	COG3944	biosynthesis protein
S100761_03495	COG1396	sequence-specific DNA binding
S100761_03496	COG2272	Belongs to the type-B carboxylesterase lipase family
S100761_03498	COG3479	Phenolic acid decarboxylase
S100761_03500	COG1794	racemase activity, acting on amino acids and derivatives
S100761_03501	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100761_03502	COG1621	beta-fructofuranosidase activity
S100761_03503	COG1621	beta-fructofuranosidase activity
S100761_03504	COG0531	amino acid
S100761_03505	COG1309	transcriptional regulator
S100761_03506	COG2076	Multidrug Resistance protein
S100761_03507	COG2076	Multidrug Resistance protein
S100761_03510	COG0740	serine-type endopeptidase activity
S100761_03511	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100761_03512	COG0366	Alpha amylase catalytic
S100761_03513	COG1554	hydrolase, family 65, central catalytic
S100761_03514	COG5521	maltodextrose utilization protein MalA
S100761_03515	COG3833	ABC-type maltose transport systems, permease component
S100761_03516	COG1175	transmembrane transport
S100761_03517	COG2182	Extracellular solute-binding protein
S100761_03518	COG0366	Alpha amylase catalytic
S100761_03519	COG1609	Transcriptional regulator
S100761_03520	COG1611	Belongs to the LOG family
S100761_03521	COG1694	Mazg nucleotide pyrophosphohydrolase
S100761_03522	COG0659	secondary active sulfate transmembrane transporter activity
S100761_03523	COG0288	reversible hydration of carbon dioxide
S100761_03524	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100761_03525	COG0577	efflux transmembrane transporter activity
S100761_03526	COG1136	(ABC) transporter
S100761_03527	COG5002	protein histidine kinase activity
S100761_03528	COG0745	RESPONSE REGULATOR receiver
S100761_03530	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S100761_03531	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_03532	COG1481	regulation of sporulation
S100761_03533	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S100761_03534	COG1660	Displays ATPase and GTPase activities
S100761_03535	COG1051	belongs to the nudix hydrolase family
S100761_03536	COG0492	ferredoxin-NADP+ reductase activity
S100761_03537	COG3883	PFAM NLP P60 protein
S100761_03537	COG0791	NLP P60 protein
S100761_03538	COG0457	Tetratricopeptide repeat
S100761_03539	COG1132	(ABC) transporter
S100761_03543	COG0140	phosphoribosyl-ATP diphosphatase activity
S100761_03543	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S100761_03544	COG0107	imidazoleglycerol-phosphate synthase activity
S100761_03545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S100761_03546	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S100761_03547	COG0131	Imidazoleglycerol-phosphate dehydratase
S100761_03548	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S100761_03549	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S100761_03550	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S100761_03551	COG4990	cell redox homeostasis
S100761_03552	COG5297	Belongs to the glycosyl hydrolase family 6
S100761_03553	COG0110	maltose O-acetyltransferase activity
S100761_03554	COG0546	phosphoglycolate phosphatase activity
S100761_03555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S100761_03556	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S100761_03557	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S100761_03558	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S100761_03559	COG0363	glucosamine-6-phosphate deaminase activity
S100761_03561	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S100761_03562	COG1846	Transcriptional regulator
S100761_03563	COG2124	cytochrome p450
S100761_03565	COG1846	Transcriptional regulator
S100761_03566	COG2814	Major facilitator Superfamily
S100761_03567	COG1950	PFAM Membrane protein of
S100761_03568	COG1983	PspC domain protein
S100761_03569	COG3595	metallopeptidase activity
S100761_03572	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100761_03573	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100761_03574	COG0556	nucleotide-excision repair
S100761_03575	COG0556	nucleotide-excision repair
S100761_03576	COG4897	Protein conserved in bacteria
S100761_03577	COG0574	Belongs to the PEP-utilizing enzyme family
S100761_03577	COG3848	Pyruvate phosphate dikinase
S100761_03578	COG1309	transcriptional regulator
S100761_03579	COG2814	Major facilitator Superfamily
S100761_03580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100761_03582	COG0793	Belongs to the peptidase S41A family
S100761_03582	COG3409	Peptidoglycan-binding domain 1 protein
S100761_03583	COG2177	Part of the ABC transporter FtsEX involved in
S100761_03584	COG2884	Cell division ATP-binding protein ftsE
S100761_03585	COG2010	Cytochrome c
S100761_03586	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100761_03587	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S100761_03588	COG0653	protein targeting
S100761_03589	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S100761_03592	COG1516	flagellar protein fliS
S100761_03593	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S100761_03594	COG1334	flagellar protein FlaG
S100761_03595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100761_03596	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S100761_03597	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
S100761_03599	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100761_03600	COG4786	Flagellar basal body rod
S100761_03600	COG1256	bacterial-type flagellum assembly
S100761_03601	COG3418	PFAM FlgN family protein
S100761_03602	COG2747	anti-sigma28 factor FlgM
S100761_03604	COG1040	competence protein
S100761_03606	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S100761_03607	COG1307	EDD domain protein, DegV family
S100761_03608	COG2197	response regulator
S100761_03609	COG4585	Histidine kinase
S100761_03610	COG1739	Uncharacterized protein family UPF0029
S100761_03611	COG1316	TRANSCRIPTIONal
S100761_03618	COG1131	(ABC) transporter
S100761_03620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100761_03621	COG0438	transferase activity, transferring glycosyl groups
S100761_03622	COG1215	transferase activity, transferring glycosyl groups
S100761_03623	COG3206	protein involved in exopolysaccharide biosynthesis
S100761_03624	COG3307	-O-antigen
S100761_03626	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100761_03627	COG0297	glycogen (starch) synthase activity
S100761_03627	COG0438	transferase activity, transferring glycosyl groups
S100761_03628	COG2244	polysaccharide biosynthetic process
S100761_03630	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100761_03630	COG2247	cell wall binding repeat
S100761_03631	COG2247	cell wall binding repeat
S100761_03631	COG2385	sporulation resulting in formation of a cellular spore
S100761_03633	COG1316	TRANSCRIPTIONal
S100761_03634	COG1316	TRANSCRIPTIONal
S100761_03635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S100761_03636	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100761_03638	COG1134	teichoic acid transport
S100761_03639	COG1682	transport, permease protein
S100761_03642	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100761_03642	COG0463	Glycosyl transferase, family 2
S100761_03643	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100761_03644	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S100761_03645	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S100761_03646	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100761_03647	COG4193	domain, Protein
S100761_03648	COG1482	cell wall glycoprotein biosynthetic process
S100761_03649	COG0697	spore germination
S100761_03650	COG0814	amino acid
S100761_03652	COG2814	Major facilitator Superfamily
S100761_03653	COG1316	TRANSCRIPTIONal
S100761_03654	COG0561	phosphatase activity
S100761_03655	COG2801	Transposase and inactivated derivatives
S100761_03657	COG0791	NLP P60 protein
S100761_03659	COG2843	Capsule synthesis protein
S100761_03661	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100761_03662	COG1609	Transcriptional regulator
S100761_03663	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100761_03664	COG1869	D-ribose catabolic process
S100761_03665	COG1129	ABC transporter
S100761_03666	COG1172	Belongs to the binding-protein-dependent transport system permease family
S100761_03667	COG1879	ABC-type sugar transport system periplasmic component
S100761_03668	COG3103	Sh3 type 3 domain protein
S100761_03670	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100761_03671	COG3527	Alpha-acetolactate decarboxylase
S100761_03672	COG0028	Belongs to the TPP enzyme family
S100761_03673	COG0583	DNA-binding transcription factor activity
S100761_03674	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S100761_03677	COG5337	Spore coat protein CotH
S100761_03679	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100761_03681	COG0405	Gamma-glutamyltransferase
S100761_03682	COG1522	sequence-specific DNA binding
S100761_03683	COG2059	Chromate
S100761_03684	COG2059	Chromate
S100761_03686	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100761_03687	COG0583	DNA-binding transcription factor activity
S100761_03691	COG5444	nuclease activity
S100761_03694	COG5444	nuclease activity
S100761_03697	COG3878	Protein conserved in bacteria
S100761_03698	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100761_03699	COG4464	protein tyrosine phosphatase activity
S100761_03700	COG0489	protein tyrosine kinase activity
S100761_03701	COG3944	biosynthesis protein
S100761_03703	COG4715	Zinc finger, swim domain protein
S100761_03704	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100761_03705	COG0561	phosphatase activity
S100761_03706	COG1349	DNA-binding transcription factor activity
S100761_03707	COG0629	single-stranded DNA binding
S100761_03710	COG3764	Sortase (surface protein transpeptidase)
S100761_03712	COG2972	Histidine kinase
S100761_03712	COG0745	RESPONSE REGULATOR receiver
S100761_03713	COG1970	mechanosensitive ion channel activity
S100761_03714	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100761_03715	COG0457	Tetratricopeptide repeat
S100761_03716	COG4786	Flagellar basal body rod
S100761_03717	COG4786	Flagellar basal body rod
S100761_03718	COG1077	Cell shape determining protein MreB Mrl
S100761_03719	COG1609	Transcriptional regulator
S100761_03720	COG1846	Transcriptional regulator
S100761_03721	COG2814	Major facilitator Superfamily
S100761_03722	COG3420	alginic acid biosynthetic process
S100761_03723	COG1953	Uracil, thiamine, allantoin
S100761_03724	COG0477	Major facilitator Superfamily
S100761_03725	COG1335	isochorismatase
S100761_03727	COG0004	ammonium transporteR
S100761_03728	COG0347	Belongs to the P(II) protein family
S100761_03729	COG0671	phosphoesterase, PA-phosphatase related
S100761_03731	COG0739	heme binding
S100761_03732	COG1247	-acetyltransferase
S100761_03734	COG2089	acid synthase
S100761_03736	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100761_03737	COG0789	Transcriptional regulator
S100761_03739	COG2910	NAD(P)H-binding
S100761_03740	COG1959	2 iron, 2 sulfur cluster binding
S100761_03741	COG0804	urea catabolic process
S100761_03742	COG0832	Belongs to the urease beta subunit family
S100761_03743	COG0831	urea catabolic process
S100761_03744	COG3237	CsbD-like
S100761_03745	COG1994	Peptidase M50
S100761_03746	COG0457	Tetratricopeptide repeat
S100761_03747	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S100761_03748	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S100761_03750	COG2304	oxidoreductase activity
S100761_03751	COG2304	oxidoreductase activity
S100761_03752	COG2385	sporulation resulting in formation of a cellular spore
S100761_03753	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100761_03755	COG4836	Membrane
S100761_03757	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S100761_03758	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S100761_03759	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S100761_03760	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S100761_03761	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100761_03762	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S100761_03763	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100761_03764	COG0356	it plays a direct role in the translocation of protons across the membrane
S100761_03766	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S100761_03767	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S100761_03768	COG4475	Protein of unknown function (DUF436)
S100761_03769	COG0698	ribose 5-phosphate isomerase
S100761_03770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100761_03771	COG1971	Probably functions as a manganese efflux pump
S100761_03772	COG0009	L-threonylcarbamoyladenylate synthase
S100761_03773	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S100761_03777	COG2890	protein-(glutamine-N5) methyltransferase activity
S100761_03778	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S100761_03779	COG0346	lactoylglutathione lyase activity
S100761_03780	COG0789	Transcriptional regulator
S100761_03781	COG0679	Auxin Efflux Carrier
S100761_03782	COG0281	malic enzyme
S100761_03783	COG1435	thymidine kinase activity
S100761_03784	COG0254	rRNA binding
S100761_03785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S100761_03786	COG1494	fructose-1,6-bisphosphatase
S100761_03787	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100761_03788	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S100761_03789	COG0191	fructose-bisphosphate aldolase activity
S100761_03790	COG2204	response regulator
S100761_03791	COG4821	SIS domain
S100761_03792	COG2801	Transposase and inactivated derivatives
S100761_03794	COG0504	CTP synthase activity
S100761_03795	COG3343	RNA polymerase activity
S100761_03796	COG1960	acyl-CoA dehydrogenase activity
S100761_03797	COG2181	nitrate reductase activity
S100761_03797	COG0247	lactate metabolic process
S100761_03798	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100761_03799	COG4294	response to UV
S100761_03801	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100761_03802	COG1132	(ABC) transporter
S100761_03803	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100761_03804	COG2181	nitrate reductase activity
S100761_03805	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
S100761_03806	COG1140	nitrate reductase beta subunit
S100761_03807	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
S100761_03808	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100761_03810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100761_03811	COG2223	nitrite transmembrane transporter activity
S100761_03812	COG0018	arginyl-trna synthetase
S100761_03813	COG4506	Protein conserved in bacteria
S100761_03815	COG0535	radical SAM domain protein
S100761_03817	COG1131	(ABC) transporter
S100761_03818	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100761_03819	COG0612	Peptidase, M16
S100761_03820	COG0612	Peptidase, M16
S100761_03822	COG3391	amine dehydrogenase activity
S100761_03823	COG3391	amine dehydrogenase activity
S100761_03824	COG0457	Tetratricopeptide repeat
S100761_03826	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S100761_03827	COG0010	Belongs to the arginase family
S100761_03828	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S100761_03829	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100761_03831	COG1994	Peptidase M50
S100761_03832	COG1942	4-Oxalocrotonate Tautomerase
S100761_03833	COG1846	Transcriptional regulator
S100761_03834	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100761_03836	COG0477	Major facilitator Superfamily
S100761_03837	COG1959	2 iron, 2 sulfur cluster binding
S100761_03838	COG3465	dGTPase activity
S100761_03839	COG1078	dGTPase activity
S100761_03840	COG4844	belongs to the
S100761_03842	COG0697	spore germination
S100761_03843	COG0095	Lipoate-protein ligase
S100761_03844	COG0583	DNA-binding transcription factor activity
S100761_03845	COG0280	phosphate acetyltransferase
S100761_03847	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03848	COG0436	Aminotransferase
S100761_03849	COG2814	Major facilitator Superfamily
S100761_03850	COG0151	Belongs to the GarS family
S100761_03851	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03852	COG1917	Cupin 2, conserved barrel domain protein
S100761_03853	COG0077	Prephenate dehydratase
S100761_03854	COG2814	Major facilitator Superfamily
S100761_03855	COG0833	amino acid
S100761_03856	COG4187	Peptidase family M20/M25/M40
S100761_03857	COG1012	belongs to the aldehyde dehydrogenase family
S100761_03858	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100761_03860	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
S100761_03861	COG1091	dTDP-4-dehydrorhamnose reductase activity
S100761_03862	COG1088	dTDP-glucose 4,6-dehydratase activity
S100761_03863	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
S100761_03864	COG3980	spore coat polysaccharide biosynthesis protein
S100761_03865	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
S100761_03866	COG2089	acid synthase
S100761_03867	COG0456	acetyltransferase
S100761_03868	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100761_03869	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100761_03870	COG0463	Glycosyl transferase, family 2
S100761_03872	COG2363	Small membrane protein
S100761_03873	COG2233	PERMEase
S100761_03875	COG1012	belongs to the aldehyde dehydrogenase family
S100761_03876	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S100761_03877	COG1216	Glycosyl transferase, family 2
S100761_03878	COG0351	phosphomethylpyrimidine kinase
S100761_03880	COG1621	beta-fructofuranosidase activity
S100761_03881	COG1263	PTS System
S100761_03881	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_03882	COG2116	formate transmembrane transporter activity
S100761_03883	COG3711	transcriptional antiterminator
S100761_03885	COG1404	Belongs to the peptidase S8 family
S100761_03886	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100761_03887	COG0778	Nitroreductase
S100761_03888	COG0772	Belongs to the SEDS family
S100761_03891	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100761_03892	COG1845	cytochrome c oxidase, subunit III
S100761_03893	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S100761_03894	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S100761_03895	COG2261	transglycosylase associated protein
S100761_03896	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S100761_03897	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S100761_03898	COG2246	polysaccharide biosynthetic process
S100761_03899	COG1309	transcriptional regulator
S100761_03901	COG3162	membrane
S100761_03902	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100761_03903	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S100761_03904	COG2837	iron assimilation
S100761_03905	COG2822	iron ion transport
S100761_03906	COG0672	)-iron permease
S100761_03907	COG0352	thiamine-phosphate diphosphorylase activity
S100761_03908	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S100761_03909	COG0583	DNA-binding transcription factor activity
S100761_03910	COG1380	Effector of murein hydrolase LrgA
S100761_03911	COG1346	cytolysis
S100761_03912	COG2814	Major facilitator Superfamily
S100761_03913	COG4895	conserved protein (DUF2196)
S100761_03914	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S100761_03915	COG0346	lactoylglutathione lyase activity
S100761_03917	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100761_03918	COG1404	Belongs to the peptidase S8 family
S100761_03919	COG1404	Belongs to the peptidase S8 family
S100761_03920	COG1263	PTS System
S100761_03920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_03921	COG3711	transcriptional antiterminator
S100761_03922	COG1442	glycosyl transferase family 8
S100761_03923	COG5522	Integral membrane protein (intg_mem_TP0381)
S100761_03924	COG1846	Transcriptional regulator
S100761_03925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100761_03926	COG2234	aminopeptidase activity
S100761_03927	COG2357	RelA SpoT domain protein
S100761_03928	COG2801	Transposase and inactivated derivatives
S100761_03930	COG1575	Belongs to the MenA family. Type 1 subfamily
S100761_03932	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100761_03933	COG1696	Membrane protein involved in D-alanine export
S100761_03934	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100761_03935	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S100761_03936	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
S100761_03937	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100761_03938	COG1486	melibiose metabolic process
S100761_03939	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100761_03940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100761_03941	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100761_03942	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100761_03942	COG3711	transcriptional antiterminator
S100761_03944	COG2094	Belongs to the DNA glycosylase MPG family
S100761_03945	COG0753	catalase activity
S100761_03946	COG2814	Major facilitator Superfamily
S100761_03947	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100761_03948	COG1131	(ABC) transporter
S100761_03952	COG1595	DNA-templated transcription, initiation
S100761_03953	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S100761_03954	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S100761_03955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S100761_03956	COG4988	ABC transporter
S100761_03957	COG1294	oxidase, subunit
S100761_03958	COG1271	oxidase subunit
S100761_03959	COG3493	citrate carrier protein
S100761_03960	COG0501	Belongs to the peptidase M48B family
S100761_03962	COG0726	polysaccharide deacetylase
S100761_03963	COG3842	ATPase activity
S100761_03964	COG2508	Transcriptional regulator
S100761_03965	COG1012	belongs to the aldehyde dehydrogenase family
S100761_03966	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100761_03968	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100761_03970	COG4585	Histidine kinase
S100761_03971	COG2197	response regulator
S100761_03972	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100761_03974	COG4894	glucomannan catabolic process
S100761_03975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100761_03976	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100761_03977	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_03978	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S100761_03979	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S100761_03980	COG2610	gluconate transmembrane transporter activity
S100761_03981	COG0500	methyltransferase
S100761_03982	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100761_03985	COG0693	protein deglycase activity
S100761_03985	COG0753	catalase activity
S100761_03986	COG2851	Citrate transporter
S100761_03987	COG2273	Hydrolase Family 16
S100761_03988	COG3711	transcriptional antiterminator
S100761_03990	COG2270	Major facilitator Superfamily
S100761_03991	COG0513	Belongs to the DEAD box helicase family
S100761_03992	COG3401	FG-GAP repeat protein
S100761_03992	COG2755	lipolytic protein G-D-S-L family
S100761_04016	COG0697	spore germination
S100761_04017	COG0589	response to stress
S100761_04018	COG2723	6-phospho-beta-galactosidase activity
S100761_04019	COG1263	PTS System
S100761_04019	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_04019	COG2190	(PTS) system
S100761_04021	COG5444	nuclease activity
S100761_04023	COG5444	nuclease activity
S100761_04026	COG3507	Belongs to the glycosyl hydrolase 43 family
S100761_04028	COG2986	histidine ammonia-lyase
S100761_04029	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S100761_04030	COG1228	amidohydrolase
S100761_04031	COG0010	Belongs to the arginase family
S100761_04032	COG0833	amino acid
S100761_04033	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S100761_04034	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100761_04035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S100761_04036	COG2390	Transcriptional regulator
S100761_04038	COG3192	ethanolamine utilization protein
S100761_04039	COG2079	MmgE PrpD family protein
S100761_04041	COG1126	abc transporter atp-binding protein
S100761_04042	COG0765	amino acid transport
S100761_04043	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100761_04046	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S100761_04047	COG0561	phosphatase activity
S100761_04053	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100761_04054	COG5294	Protein conserved in bacteria
S100761_04055	COG0577	efflux transmembrane transporter activity
S100761_04056	COG1136	(ABC) transporter
S100761_04057	COG2205	protein histidine kinase activity
S100761_04058	COG0745	RESPONSE REGULATOR receiver
S100761_04059	COG0191	fructose-bisphosphate aldolase activity
S100761_04060	COG1082	Xylose isomerase domain protein TIM barrel
S100761_04061	COG1082	Xylose isomerase domain protein TIM barrel
S100761_04062	COG0673	inositol 2-dehydrogenase activity
S100761_04063	COG2814	Major facilitator Superfamily
S100761_04064	COG1082	Xylose isomerase domain protein TIM barrel
S100761_04065	COG3962	Belongs to the TPP enzyme family
S100761_04066	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100761_04068	COG1012	belongs to the aldehyde dehydrogenase family
S100761_04069	COG1349	DNA-binding transcription factor activity
S100761_04070	COG0667	Aldo Keto reductase
S100761_04073	COG2814	Major facilitator Superfamily
S100761_04074	COG0326	Molecular chaperone. Has ATPase activity
S100761_04076	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_04077	COG1309	transcriptional regulator
S100761_04078	COG1012	belongs to the aldehyde dehydrogenase family
S100761_04079	COG1714	RDD family
S100761_04081	COG1714	RDD family
S100761_04082	COG2311	Membrane
S100761_04083	COG1917	Cupin 2, conserved barrel domain protein
S100761_04084	COG1309	transcriptional regulator
S100761_04085	COG1028	Short-chain dehydrogenase reductase Sdr
S100761_04086	COG1846	Transcriptional regulator
S100761_04087	COG1380	Effector of murein hydrolase LrgA
S100761_04088	COG1346	cytolysis
S100761_04089	COG5039	Polysaccharide pyruvyl transferase
S100761_04090	COG1929	Belongs to the glycerate kinase type-1 family
S100761_04091	COG1802	Transcriptional regulator
S100761_04092	COG1070	Carbohydrate kinase
S100761_04093	COG2610	gluconate transmembrane transporter activity
S100761_04094	COG2610	gluconate transmembrane transporter activity
S100761_04095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100761_04096	COG0450	alkyl hydroperoxide reductase
S100761_04097	COG3634	alkyl hydroperoxide reductase activity
S100761_04098	COG2723	6-phospho-beta-galactosidase activity
S100761_04099	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100761_04099	COG2190	(PTS) system
S100761_04099	COG1263	PTS System
S100761_04100	COG2188	Transcriptional regulator
S100761_04101	COG1074	ATP-dependent DNA helicase activity
S100761_04102	COG0501	Belongs to the peptidase M48B family
S100761_04106	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
S100761_04108	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S100761_04111	COG1063	alcohol dehydrogenase
S100761_04115	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
S100761_04116	COG0456	acetyltransferase
S100761_04117	COG0457	Tetratricopeptide repeat
S100761_04118	COG0457	Tetratricopeptide repeat
S100761_04120	COG0010	Belongs to the arginase family
S100761_04121	COG0833	amino acid
S100761_04122	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100761_04126	COG5658	integral membrane protein
S100761_04127	COG0640	Transcriptional regulator
S100761_04128	COG3829	transcription factor binding
S100761_04129	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100761_04130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S100761_04131	COG4853	Protein conserved in bacteria
S100761_04132	COG4863	YycH protein
S100761_04133	COG5002	protein histidine kinase activity
S100761_04134	COG0745	RESPONSE REGULATOR receiver
S100761_04140	COG0346	lactoylglutathione lyase activity
S100761_04141	COG0305	Participates in initiation and elongation during chromosome replication
S100761_04144	COG3093	addiction module antidote protein HigA
S100761_04145	COG2807	transmembrane transport
S100761_04146	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100761_04147	COG0359	binds to the 23S rRNA
S100761_04148	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
S100761_04149	COG4241	membrane
S100761_04151	COG5577	PFAM Coat F domain
S100761_04152	COG1733	regulation of RNA biosynthetic process
S100761_04153	COG1227	inorganic diphosphatase activity
S100761_04156	COG2271	Major facilitator Superfamily
S100761_04157	COG4978	Transcriptional regulator
S100761_04157	COG0789	Transcriptional regulator
S100761_04159	COG4319	ketosteroid isomerase
S100761_04160	COG1357	PFAM Pentapeptide repeats (8 copies)
S100761_04161	COG2814	Major facilitator Superfamily
S100761_04162	COG0583	DNA-binding transcription factor activity
S100761_04163	COG2153	protein acetylation
S100761_04165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100761_04166	COG1846	Transcriptional regulator
S100761_04167	COG2153	protein acetylation
S100761_04168	COG2364	Membrane
S100761_04169	COG0456	acetyltransferase
S100761_04170	COG2315	Protein conserved in bacteria
S100761_04171	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100761_04172	COG1331	Highly conserved protein containing a thioredoxin domain
S100761_04173	COG1266	CAAX protease self-immunity
S100761_04174	COG2814	Major facilitator Superfamily
S100761_04174	COG0477	Major facilitator Superfamily
S100761_04175	COG0110	maltose O-acetyltransferase activity
S100761_04176	COG0346	lactoylglutathione lyase activity
S100761_04177	COG1609	Transcriptional regulator
S100761_04178	COG0708	Exodeoxyribonuclease III
S100761_04179	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S100761_04180	COG0629	single-stranded DNA binding
S100761_04181	COG0360	Binds together with S18 to 16S ribosomal RNA
S100761_04182	COG0012	GTP binding
S100761_04183	COG0243	molybdopterin cofactor binding
S100761_04184	COG4481	Protein conserved in bacteria
S100761_04185	COG3949	Membrane
S100761_04187	COG1475	DNA binding
S100761_04188	COG1192	Involved in chromosome partitioning
S100761_04190	COG1475	DNA binding
S100761_04191	COG0357	Ribosomal RNA small subunit methyltransferase G
S100761_04192	COG0445	tRNA wobble uridine modification
S100761_04193	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S100761_04194	COG1847	R3H domain protein
S100761_04195	COG0706	membrane insertase activity
S100761_04196	COG0594	ribonuclease P activity