locus-tag class description S101392_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) S101392_00002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) S101392_00003 ENOG410848D S4 domain protein YaaA S101392_00006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S101392_00007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S101392_00014 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) S101392_00016 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) S101392_00017 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) S101392_00018 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) S101392_00020 ENOG4105ZMH deoxynucleoside kinase S101392_00022 ENOG4105VRS hydrolase family 18 S101392_00023 ENOG4105GTG Isochorismatase S101392_00024 ENOG4108Z6B deaminase S101392_00025 ENOG4105C6E dna polymerase iii S101392_00026 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) S101392_00027 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) S101392_00029 ENOG41067KS pro-sigma K processing S101392_00037 ENOG4105CDW Resistance protein S101392_00038 ENOG4105CXN decarboxylase S101392_00039 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) S101392_00040 ENOG4105X0R protein from nitrogen regulatory protein P-II S101392_00041 ENOG4105XVJ Protein of unknown function (DUF327) S101392_00042 ENOG4105FA2 dna polymerase iii S101392_00043 ENOG4105MA4 psp1 domain protein S101392_00044 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) S101392_00045 ENOG41060K3 Methyltransferase S101392_00046 ENOG4105VC4 domain protein S101392_00047 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) S101392_00048 ENOG4105KRN Transcriptional regulator, abrb family S101392_00049 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) S101392_00050 ENOG4105F8V Hydrolase, tatD family S101392_00051 ENOG41069ER domain protein S101392_00053 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) S101392_00054 ENOG4105XFA sporulation peptidase YabG S101392_00055 ENOG4105W42 Veg protein S101392_00056 ENOG4105XEW small acid-soluble spore protein S101392_00057 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) S101392_00058 ENOG4105DFT pur operon repressor S101392_00059 ENOG4105KME endoribonuclease L-psp S101392_00060 ENOG4105K4W Could be involved in septation (By similarity) S101392_00061 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) S101392_00062 ENOG4105C5T Phosphoribosyl pyrophosphate synthase S101392_00063 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) S101392_00064 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) S101392_00066 ENOG4108JA2 transcriptioN-repair coupling factor S101392_00067 ENOG4108M14 stage v sporulation protein t S101392_00069 ENOG4108IY2 MazG family S101392_00070 ENOG41082I2 s4 domain protein S101392_00071 ENOG4105VYY sporulation protein yabp S101392_00074 ENOG41060GV RNA binding s1 domain protein S101392_00080 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) S101392_00081 ENOG4108UGV hypoxanthine phosphoribosyltransferase S101392_00082 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) S101392_00084 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) S101392_00085 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase S101392_00086 ENOG4105C6T cysteine synthase S101392_00087 ENOG4105CRQ synthase (Component I) S101392_00088 ENOG4105DDQ anthranilate synthase S101392_00089 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 S101392_00090 ENOG4105EEI dihydropteroate synthase S101392_00091 ENOG4105KRF dihydroneopterin aldolase S101392_00092 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase S101392_00094 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) S101392_00095 ENOG4105CRK lysyL-tRNA synthetase S101392_00112 ENOG4108Z0C Uvrb UvrC protein S101392_00113 ENOG41066A3 ATP guanido phosphotransferase S101392_00115 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) S101392_00116 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) S101392_00117 ENOG4105CTP PilT protein domain protein S101392_00118 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) S101392_00119 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) S101392_00120 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) S101392_00121 ENOG4105D7W serine acetyltransferase S101392_00122 ENOG4105C8N cysteinyl-tRNA synthetase S101392_00123 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) S101392_00124 ENOG4105C2N RNA methyltransferase TrmH family group 3 S101392_00125 ENOG4105M0M Tetracycline resistance protein S101392_00128 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) S101392_00129 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) S101392_00131 ENOG4108VZM 50s ribosomal protein L10 S101392_00132 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) S101392_00133 ENOG4107Y49 methyltransferase S101392_00134 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S101392_00135 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S101392_00136 ENOG4105XPM ribosomal protein S101392_00137 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) S101392_00138 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) S101392_00139 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) S101392_00140 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) S101392_00141 ENOG4107SKW Inherit from COG: Alpha beta hydrolase S101392_00142 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) S101392_00143 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) S101392_00144 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) S101392_00145 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) S101392_00146 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity S101392_00147 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) S101392_00148 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) S101392_00149 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) S101392_00150 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) S101392_00151 ENOG41082SA 50s ribosomal protein l29 S101392_00152 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal S101392_00153 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) S101392_00155 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits S101392_00157 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) S101392_00158 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) S101392_00159 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) S101392_00160 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) S101392_00161 ENOG4105VPB 50S ribosomal protein L30 S101392_00162 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) S101392_00163 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) S101392_00165 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) S101392_00166 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) S101392_00168 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits S101392_00169 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) S101392_00170 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S101392_00171 ENOG4108ZT0 50S ribosomal protein l17 S101392_00172 ENOG4108JJB ABC transporter S101392_00173 ENOG4108JJB ABC transporter S101392_00174 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) S101392_00175 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) S101392_00176 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) S101392_00177 ENOG4108UJD 30S ribosomal protein S9 S101392_00178 ENOG4108I0C methyltransferase S101392_00181 ENOG4105D1F ATP-binding protein S101392_00184 ENOG4108NMV polysaccharide deacetylase S101392_00194 ENOG41067QW Transcriptional regulator S101392_00209 ENOG4105NI8 Cytosine-specific methyltransferase S101392_00213 ENOG410906S phage-like element pbsx protein xkdt S101392_00229 ENOG4105CHH sulfate transporter S101392_00232 ENOG4108SA1 esterase S101392_00236 ENOG410874W AraC family transcriptional regulator S101392_00237 ENOG4105EHZ conserved protein UCP016719 S101392_00238 ENOG4105D17 glycoside hydrolase, family 3 domain protein S101392_00242 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate S101392_00244 ENOG4105EWC Purine nucleoside phosphorylase S101392_00250 ENOG4105EMN RNA polymerase sigma factor S101392_00252 ENOG4105C8B TIGR00159 family S101392_00253 ENOG4107U5W ybbr family S101392_00254 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) S101392_00255 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) S101392_00257 ENOG4105D03 DNA-3-methyladenine glycosylase II S101392_00259 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S101392_00260 ENOG4108TWJ NADH dehydrogenase subunit 5 S101392_00265 ENOG4105GPN Uncharacterized conserved protein (DUF2294) S101392_00267 ENOG4105WAB arsR family transcriptional regulator S101392_00268 ENOG4108RWP Major Facilitator Superfamily protein S101392_00270 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) S101392_00271 ENOG4105C4R Atp-dependent dna helicase S101392_00277 ENOG4105G0J serine threonine protein kinase S101392_00279 ENOG4106K80 S101392_00281 ENOG4106DDH Sporulation-specific SASP protein S101392_00283 ENOG4108HWY Beta-lactamase S101392_00284 ENOG4107E6A Cytochrome p-450 S101392_00286 ENOG4107QTZ amino acid S101392_00287 ENOG4107VXM glycerophosphoryl diester phosphodiesterase S101392_00288 ENOG4105CXY transporter S101392_00290 ENOG410645S MarR family Transcriptional regulator S101392_00291 ENOG4105DCM major facilitator superfamily S101392_00292 ENOG410631K Membrane S101392_00293 ENOG4106AXJ AraC family transcriptional regulator S101392_00294 ENOG41065RQ ADP-ribosylation crystallin J1 S101392_00295 ENOG4106BHF S101392_00296 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR S101392_00297 ENOG4108TCS Glutamyl endopeptidase S101392_00299 ENOG4108WC5 Alpha Beta Hydrolase Fold protein S101392_00300 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase S101392_00301 ENOG4107ZTW SNARE associated Golgi S101392_00305 ENOG4105C72 UPF0176 protein S101392_00307 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane S101392_00308 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) S101392_00309 ENOG4108X79 transcriptional regulator S101392_00311 ENOG4105CM2 brancheD-chain amino acid aminotransferase S101392_00312 ENOG4108IQI permease S101392_00313 ENOG4108J5H Homocysteine s-methyltransferase S101392_00315 ENOG4105CSV Glutaminase S101392_00318 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase S101392_00319 ENOG4105C26 Dehydrogenase S101392_00320 ENOG4105DJB Major Facilitator Superfamily S101392_00321 ENOG4105EQX glucarate dehydratase S101392_00322 ENOG41073TP transcriptional regulator S101392_00323 ENOG4105CTX dehydratase S101392_00326 ENOG4106UX7 integral membrane protein S101392_00327 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101392_00333 ENOG4105MUA Resistance protein S101392_00334 ENOG4105DGI Alkaline phosphatase S101392_00335 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S101392_00336 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S101392_00337 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) S101392_00338 ENOG4107EPV Aminotransferase class V S101392_00339 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101392_00340 ENOG4105J7D transcriptional regulator S101392_00341 ENOG4107RB3 L-asparaginase S101392_00342 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold S101392_00344 ENOG41060AI SEC-C motif S101392_00346 ENOG4107Y7X LytTR S101392_00347 ENOG4108IUW ABC transporter S101392_00348 ENOG4108SDH ABC, transporter S101392_00349 ENOG4107SET aldo keto reductase S101392_00355 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S101392_00357 ENOG4105DSE periplasmic solute binding protein S101392_00358 ENOG4105DIK (ABC) transporter S101392_00360 ENOG4105DEN Luciferase family S101392_00361 ENOG4108N0M stress protein S101392_00362 ENOG4106FN3 tellurium resistance protein S101392_00363 ENOG4106FN3 tellurium resistance protein S101392_00364 ENOG4107TS3 membrane protein, TerC S101392_00365 ENOG4108TTB tellurium resistance protein S101392_00367 ENOG41079KZ Major Facilitator Superfamily S101392_00368 ENOG4107XZQ multidrug resistance protein S101392_00369 ENOG4108A65 Transcriptional regulator S101392_00370 ENOG4108IJ7 Glycine betaine S101392_00371 ENOG4107SQ8 Glycine betaine S101392_00377 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) S101392_00384 ENOG4105EIG urea carboxylase-associated protein 1 S101392_00385 ENOG4107RA1 nh(3)-dependent nad( ) synthetase S101392_00386 ENOG4105I1F Resistance protein S101392_00387 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) S101392_00388 ENOG41089UC methyltransferase, type 11 S101392_00389 ENOG4105C5Q Transcriptional regulator S101392_00390 ENOG4105I82 acetyl xylan esterase S101392_00391 ENOG410756H nucleotidyltransferase S101392_00393 ENOG4105C26 Dehydrogenase S101392_00394 ENOG4105CK7 Sodium proline symporter S101392_00395 ENOG4107YHD transcriptional regulator S101392_00397 ENOG4108PJD permease S101392_00398 ENOG4105U6C Alpha beta hydrolase fold protein S101392_00400 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S101392_00401 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit S101392_00402 ENOG4108IFG nitrite reductase, (NAD(P)H) S101392_00403 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) S101392_00407 ENOG4105S7A ErfK ybiS ycfS ynhG family protein S101392_00408 ENOG4105CKI cobalamin synthesis protein S101392_00409 ENOG4105E5Q amino acid AbC transporter S101392_00410 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein S101392_00412 ENOG4105CS2 ec 3.2.1.21 S101392_00415 ENOG4105C8Q Methyl-accepting chemotaxis S101392_00416 ENOG41080HJ 6-phospho 3-hexuloisomerase S101392_00417 ENOG4108VA3 3-hexulose-6-phosphate synthase S101392_00418 ENOG4105KVH Transcriptional regulator S101392_00419 ENOG4105CEY Amp-dependent synthetase and ligase S101392_00425 ENOG4105SX7 Transporter S101392_00427 ENOG4105W8Z 4'-phosphopantetheinyl transferase S101392_00429 ENOG4105CDA abc transporter atp-binding protein S101392_00430 ENOG4105DRP amino acid AbC transporter S101392_00432 ENOG4106P55 Transcriptional regulator S101392_00433 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase S101392_00434 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) S101392_00435 ENOG41069ZX S101392_00436 ENOG41069ZX S101392_00438 ENOG4105DUX Transporter S101392_00441 ENOG4105E1K spore germination protein S101392_00445 ENOG4107WD8 ABC transporter, permease S101392_00446 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101392_00447 ENOG4105BZU Histidine kinase S101392_00451 ENOG4105CFH Aspartokinase S101392_00452 ENOG4105DHS permease protein S101392_00453 ENOG4105CM4 permease protein S101392_00454 ENOG4108IPW abc transporter atp-binding protein S101392_00457 ENOG4105R8C Transcriptional regulator S101392_00458 ENOG4108DBC nitroreductase S101392_00459 ENOG41067V3 Antibiotic biosynthesis monooxygenase S101392_00460 ENOG4105YVS arsR family transcriptional regulator S101392_00462 ENOG4108JPW Aminotransferase S101392_00463 ENOG4105C26 Dehydrogenase S101392_00465 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S101392_00466 ENOG4105KTB nuclear export factor GLE1 S101392_00467 ENOG4108T5E Copper resistance protein S101392_00468 ENOG4108ZYE Transcriptional regulator S101392_00473 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S101392_00475 ENOG4108ZX0 Signal peptidase I S101392_00480 ENOG4105E7W lamb ycsf family protein S101392_00481 ENOG4105C5A transporter S101392_00482 ENOG4105CFM UPF0317 protein S101392_00483 ENOG4105P4J Allophanate hydrolase, subunit 1 S101392_00485 ENOG4107258 Transcriptional regulator S101392_00486 ENOG4105XJB lipolytic protein G-D-S-L family S101392_00488 ENOG41061CK Antibiotic biosynthesis monooxygenase S101392_00489 ENOG4107RVG penicillin-binding protein S101392_00490 ENOG4107QM2 Aldo Keto reductase S101392_00491 ENOG4105ETD TRANSCRIPTIONal S101392_00493 ENOG4105HMZ Methyltransferase S101392_00494 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S101392_00497 ENOG410606W general stress protein S101392_00499 ENOG4105VCH membrane S101392_00501 ENOG4105C9U ATP-dependent DNA helicase RecQ S101392_00504 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) S101392_00505 ENOG4107R8N Glycosyl transferase, family 2 S101392_00507 ENOG4105C0X amino acid S101392_00512 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) S101392_00514 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) S101392_00515 ENOG4105EU9 S101392_00516 ENOG4105QVS general stress protein S101392_00517 ENOG41082W1 Cupin 2, conserved barrel domain protein S101392_00520 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit S101392_00521 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism S101392_00522 ENOG4108MRH transcriptional regulatory protein S101392_00523 ENOG4107QJT sodium dicarboxylate symporter S101392_00524 ENOG4106F5Q Membrane S101392_00526 ENOG4105CJ1 ABC, transporter S101392_00529 ENOG4105FDT acyl-CoA dehydrogenase S101392_00533 ENOG4105SZ6 Thioredoxin S101392_00534 ENOG4105CPF Cell wall formation (By similarity) S101392_00535 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) S101392_00536 ENOG4105C1J atp-dependent rna helicase S101392_00537 ENOG410905X membrane-flanked domain protein S101392_00538 ENOG4105CKV Membrane S101392_00540 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) S101392_00541 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein S101392_00542 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S101392_00544 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) S101392_00545 ENOG4107MMM Anti-sigma-factor antagonist S101392_00546 ENOG4105FUA antagonist S101392_00547 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase S101392_00548 ENOG4107SGM protein serine threonine phosphatase S101392_00549 ENOG4105WN5 stage II sporulation protein S101392_00550 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) S101392_00552 ENOG41064BQ Phosphatase S101392_00566 ENOG4105CJA serine threonine protein kinase S101392_00572 ENOG4105CJA serine threonine protein kinase S101392_00573 ENOG4105BZ1 (ABC) transporter S101392_00576 ENOG4105VZ8 Transcriptional regulator S101392_00578 ENOG4105ECK Fatty Acid Desaturase S101392_00579 ENOG4105VEQ Cold shock protein S101392_00580 ENOG4108VJ1 Transcriptional regulator (CarD family S101392_00582 ENOG4108MCI Transcriptional regulator, ARAC family S101392_00583 ENOG4108UZ3 Transporter S101392_00584 ENOG41086D8 Transcriptional regulator S101392_00585 ENOG4107U9B transcriptional regulator S101392_00586 ENOG4105DXI Major Facilitator superfamily S101392_00588 ENOG4105CZ9 Domain of unknown function (DU1801) S101392_00589 ENOG4105GIG S101392_00591 ENOG4105KRI phosphocarrier protein (HPr S101392_00592 ENOG4105ST3 Transcriptional regulator S101392_00593 ENOG4105T38 integral membrane protein S101392_00594 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101392_00595 ENOG4108ZMQ domain protein S101392_00596 ENOG4105MJ9 esterase S101392_00597 ENOG4107Z6X Transcriptional regulator S101392_00599 ENOG4105EQ0 Major Facilitator superfamily S101392_00600 ENOG4108JGH Tetr family transcriptional regulator S101392_00601 ENOG41082YX Transcriptional regulator, arsr family S101392_00602 ENOG4107R5R arsenical pump membrane protein S101392_00603 ENOG4105Z7P Acetyltransferase (GNAT) family S101392_00604 ENOG4107Y9U Membrane S101392_00606 ENOG4108SQ9 flavin reductase domain protein, FMN-binding S101392_00607 ENOG4108ZHR arsR family transcriptional regulator S101392_00608 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) S101392_00610 ENOG4105ENE Histidine kinase S101392_00611 ENOG4108VB1 regulatoR S101392_00612 ENOG4105EYF MMPL domain protein S101392_00614 ENOG4108WC5 Alpha Beta Hydrolase Fold protein S101392_00615 ENOG4108UQV Membrane S101392_00616 ENOG4108Z5V transcriptional regulator, merr family S101392_00617 ENOG41076HS cation diffusion facilitator family transporter S101392_00618 ENOG4108TVJ Nitroreductase S101392_00619 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase S101392_00620 ENOG4108VGI doxx family S101392_00621 ENOG4105XXY Thioredoxin S101392_00625 ENOG410900G Protein of unknown function (DUF421) S101392_00626 ENOG4108QY0 Membrane S101392_00630 ENOG4105PF9 Transcriptional regulator S101392_00632 ENOG4105WQG acetyltransferase S101392_00634 ENOG4105C85 amino acid S101392_00636 ENOG41062A4 Transcriptional regulator S101392_00637 ENOG4105EYF MMPL domain protein S101392_00638 ENOG4108TVJ Nitroreductase S101392_00639 ENOG4105FS7 Transcriptional regulator S101392_00640 ENOG4105C2C drug resistance transporter, Bcr CflA S101392_00642 ENOG4105DRR Transcriptional regulator, GntR family S101392_00643 ENOG4105VRS hydrolase family 18 S101392_00646 ENOG4105G6Z alkaline phosphatase S101392_00647 ENOG4108ZMX Domain of unknown function (DU1801) S101392_00649 ENOG4108YM7 Gcn5-related n-acetyltransferase S101392_00650 ENOG4107TVP HD domain protein S101392_00651 ENOG41090UD (LipO)protein S101392_00652 ENOG4105F27 Major Facilitator S101392_00653 ENOG4105VZJ PTS System S101392_00654 ENOG4105VCP PTS System S101392_00655 ENOG4105CK1 PTS System S101392_00656 ENOG4105CS2 ec 3.2.1.21 S101392_00657 ENOG4108TZY GntR Family Transcriptional Regulator S101392_00658 ENOG4105EVU fructokinase S101392_00659 ENOG4105DG6 mannose-6-phosphate isomerase S101392_00660 ENOG4105D3P Mannan endo-1,4-beta-mannosidase S101392_00669 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) S101392_00670 ENOG4105K8N protein family UPF0079, ATPase S101392_00671 ENOG41072GX Peptidase M22 Glycoprotease S101392_00672 ENOG410801F ribosomal-protein-alanine acetyltransferase S101392_00673 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S101392_00674 ENOG4105C5H ABC transporter S101392_00675 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) S101392_00676 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) S101392_00677 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S101392_00678 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S101392_00680 ENOG4108TYN CAAX amino terminal protease family protein S101392_00681 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) S101392_00682 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) S101392_00684 ENOG4105PGZ NB-ARC domain S101392_00685 ENOG4105CPQ Dehydrogenase S101392_00686 ENOG4105CT4 transporter S101392_00688 ENOG41087YS Phage shock protein A S101392_00689 ENOG4105DQX Zinc finger domain S101392_00690 ENOG4108WV1 Pfam:DUF477 S101392_00692 ENOG4108ZMR Ion transport 2 domain-containing protein S101392_00693 ENOG4107QNK )-transporter S101392_00699 ENOG4107YUH hydrolase S101392_00701 ENOG4107STQ Multicopper oxidase S101392_00702 ENOG4105C85 amino acid S101392_00704 ENOG4105C7R Atpase associated with various cellular activities aaa_3 S101392_00710 ENOG4105C7N Xanthine uracil vitamin C permease S101392_00715 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) S101392_00716 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit S101392_00717 ENOG4105C83 adenylosuccinate lyase S101392_00718 ENOG4105C8V SAICAR synthetase S101392_00719 ENOG4105VR9 phosphoribosylformylglycinamidine synthase S101392_00720 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I S101392_00721 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii S101392_00723 ENOG4105CXB phosphoribosylaminoimidazole synthetase S101392_00724 ENOG4108V3E phosphoribosylglycinamide formyltransferase S101392_00725 ENOG4105DC1 bifunctional purine biosynthesis protein purh S101392_00726 ENOG4105C12 Phosphoribosylglycinamide synthetase S101392_00728 ENOG4105DVH amino acid S101392_00731 ENOG4108R5T secreted protein S101392_00732 ENOG4105KGF protein, YerC YecD S101392_00733 ENOG4105CBC glutamate synthase S101392_00735 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) S101392_00736 ENOG4105C4R Atp-dependent dna helicase S101392_00737 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) S101392_00739 ENOG4105CRN Aminoglycoside phosphotransferase S101392_00740 ENOG4105KT7 mgtC SapB transporter S101392_00741 ENOG4105CK7 Sodium proline symporter S101392_00742 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S101392_00743 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) S101392_00744 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S101392_00745 ENOG4108IG5 Transcriptional regulator S101392_00747 ENOG4105CBD Diacylglycerol kinase S101392_00748 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S101392_00755 ENOG4108HFV S101392_00759 ENOG4105CDY transcriptional regulatory protein S101392_00761 ENOG4105M4P Tetr family transcriptional regulator S101392_00762 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein S101392_00763 ENOG4107S9F NmrA family S101392_00764 ENOG4107S9F NmrA family S101392_00767 ENOG4105WEF catalase S101392_00768 ENOG4105M18 -acetyltransferase S101392_00771 ENOG4105C2F Histidine kinase S101392_00772 ENOG4105EQD regulatoR S101392_00773 ENOG410769Z extracellular solute-binding protein family 1 S101392_00774 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component S101392_00775 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component S101392_00776 ENOG4105F5H Glycosyl Hydrolase Family 88 S101392_00777 ENOG41075H3 AraC family transcriptional regulator S101392_00778 ENOG4107TDE lipolytic protein G-D-S-L family S101392_00781 ENOG4105CX8 fg-gap repeat protein S101392_00782 ENOG4105CX8 fg-gap repeat protein S101392_00783 ENOG4107TDE lipolytic protein G-D-S-L family S101392_00785 ENOG4105EKC S101392_00786 ENOG4105E0S extracellular solute-binding protein family 1 S101392_00788 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component S101392_00789 ENOG4105F8D glycoside hydrolase family 4 S101392_00790 ENOG4105H67 Protein of unknown function (DUF421) S101392_00791 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) S101392_00792 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily S101392_00796 ENOG4106I4J membrane S101392_00797 ENOG41082F9 transcriptional regulator S101392_00798 ENOG41061H0 Monooxygenase S101392_00799 ENOG4108R1P S101392_00800 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S101392_00801 ENOG4105E0M Sulfatase S101392_00802 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase S101392_00804 ENOG41090R9 glycosyltransferase S101392_00805 ENOG4107R51 Glycosyl transferase, family 2 S101392_00806 ENOG41090R9 glycosyltransferase S101392_00807 ENOG4105EU0 Major facilitator Superfamily S101392_00809 ENOG4105CUB amino acid S101392_00810 ENOG4105C26 Dehydrogenase S101392_00811 ENOG4105FKZ Methyl-accepting chemotaxis S101392_00812 ENOG4105C5H ABC transporter S101392_00814 ENOG4107SWG transcriptional regulator MERR family S101392_00815 ENOG4105DXB Major Facilitator superfamily S101392_00816 ENOG4105C5H ABC transporter S101392_00817 ENOG4105FDU atp-dependent rna helicase S101392_00819 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein S101392_00821 ENOG4105E6M Sulphatase-modifying factor protein S101392_00822 ENOG4105E0A ABC, transporter S101392_00823 ENOG4108U1V ABC transporter, permease S101392_00824 ENOG4105DQ5 transport system permease protein S101392_00825 ENOG4108HUF Transporter S101392_00828 ENOG4108J20 pectate lyase S101392_00829 ENOG4107QPK )-transporter S101392_00831 ENOG4108MRH transcriptional regulatory protein S101392_00836 ENOG410855V Acylphosphatase S101392_00837 ENOG4108RPX mosc domain containing protein S101392_00841 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) S101392_00846 ENOG4105GEU Spore germination protein S101392_00848 ENOG4108Q5U germination protein, ger(x)c family S101392_00849 ENOG4105E1K spore germination protein S101392_00850 ENOG4105C5Y PTS System S101392_00851 ENOG4105CG3 alpha amylase, catalytic region S101392_00852 ENOG4107414 GntR family transcriptional regulator S101392_00853 ENOG4108RCM Nitroreductase S101392_00854 ENOG4105CGH 5'-nucleotidase S101392_00855 ENOG4107RKG DJ-1/PfpI family S101392_00858 ENOG4105KJF protein tyrosine phosphatase S101392_00860 ENOG4107U9T Pfam:Ribonuclease_BN S101392_00862 ENOG4108ISG Major Facilitator S101392_00863 ENOG4105UPD Calcium Proton S101392_00865 ENOG4105D8X mechanosensitive ion channel S101392_00869 ENOG4106KE4 Dehydrogenase S101392_00870 ENOG4105D7N magnesium and cobalt transport protein CorA S101392_00872 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S101392_00876 ENOG4107RUY (E1 component), alpha subunit S101392_00878 ENOG4107QKR Dehydrogenase S101392_00881 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family S101392_00882 ENOG41069DP small acid-soluble spore protein S101392_00883 ENOG4105KK4 UPF0060 membrane protein S101392_00888 ENOG4105F8D glycoside hydrolase family 4 S101392_00889 ENOG4108Q3X Transcriptional regulator S101392_00890 ENOG4105CI1 PTS System S101392_00891 ENOG4105BZ1 (ABC) transporter S101392_00892 ENOG4105BZ1 (ABC) transporter S101392_00894 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase S101392_00895 ENOG4105ID8 Transcriptional regulator, ARAC family S101392_00896 ENOG4107QNK )-transporter S101392_00897 ENOG4107QP6 Xylose isomerase domain protein TIM barrel S101392_00898 ENOG4105CIB oxidoreductase Domain protein S101392_00900 ENOG4105BZU Histidine kinase S101392_00901 ENOG4105WH1 Two component transcriptional regulator luxr family S101392_00902 ENOG4105CJ1 ABC, transporter S101392_00903 ENOG41090VJ ABC-2 type transporter S101392_00904 ENOG4108KYE ABC-2 type transporter S101392_00905 ENOG4105U3E Transcriptional regulator S101392_00906 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold S101392_00907 ENOG4105H93 Acyltransferase family S101392_00908 ENOG4105YA8 Transcriptional regulator S101392_00909 ENOG4107Y80 Major Facilitator superfamily S101392_00910 ENOG4108YYS metal-dependent hydrolase (By similarity) S101392_00911 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101392_00912 ENOG410834F Transcriptional regulator S101392_00914 ENOG4108MES Periplasmic binding protein S101392_00915 ENOG4105DQ5 transport system permease protein S101392_00916 ENOG4108IHU transport system permease protein S101392_00917 ENOG4105JAB phenazine biosynthesis protein, phzf family S101392_00918 ENOG4107Y03 Nitroreductase S101392_00921 ENOG4105ECP epimerase S101392_00925 ENOG4105F27 Major Facilitator S101392_00929 ENOG4106AKJ S101392_00930 ENOG4105D74 hydrolase S101392_00931 ENOG4105CKK Glycosyl transferase, family 2 S101392_00932 ENOG4105EJV Membrane S101392_00933 ENOG41067AE Membrane-bound metal-dependent hydrolase S101392_00934 ENOG4105CEN a g-specific adenine glycosylase S101392_00935 ENOG4106BXE S101392_00936 ENOG4105CAN Short-chain dehydrogenase reductase Sdr S101392_00939 ENOG4105EVI UPF0374 protein S101392_00940 ENOG4105BZ1 (ABC) transporter S101392_00941 ENOG4107NBY Membrane S101392_00943 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101392_00944 ENOG4105G5W regulator Fur family S101392_00966 ENOG4108N23 SpoOM-related protein S101392_00968 ENOG4105EC3 peptidase S51, dipeptidase E S101392_00969 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) S101392_00970 ENOG4105DNP FAD linked oxidase domain protein S101392_00973 ENOG4105E2Y ABC, transporter S101392_00974 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein S101392_00975 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component S101392_00976 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) S101392_00978 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S101392_00979 ENOG4107D63 S101392_00980 ENOG4105VZ8 Transcriptional regulator S101392_00983 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) S101392_00985 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) S101392_00989 ENOG4105CYN Serine protein kinase S101392_00990 ENOG4106AKX UPF0229 protein S101392_00991 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes S101392_00992 ENOG4105CW7 secretion protein, HlyD family S101392_00993 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101392_00994 ENOG4105CS1 NAD(P)H quinone oxidoreductase S101392_00998 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family S101392_00999 ENOG4105CZV ABC transporter S101392_01000 ENOG4105CJ1 ABC, transporter S101392_01001 ENOG4108TU7 Inherit from COG: (ABC) transporter S101392_01002 ENOG4105VEQ Cold shock protein S101392_01004 ENOG4105BZU Histidine kinase S101392_01012 ENOG4108YBP pseudouridine synthase S101392_01014 ENOG41080XP Cbs domain S101392_01015 ENOG4107YBY Hydrolase S101392_01016 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S101392_01017 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S101392_01018 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator S101392_01020 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) S101392_01021 ENOG4105C6V Glycerol-3-phosphate dehydrogenase S101392_01023 ENOG4105BZU Histidine kinase S101392_01024 ENOG4105WH1 Two component transcriptional regulator luxr family S101392_01031 ENOG4105ED1 spovr family S101392_01032 ENOG4105G6Z alkaline phosphatase S101392_01035 ENOG4105BZN citrate synthase S101392_01036 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S101392_01037 ENOG4105CUB amino acid S101392_01038 ENOG4105C8J )-transporter S101392_01039 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101392_01042 ENOG4105J37 S101392_01043 ENOG4108AEY RNA polymerase sigma factor S101392_01044 ENOG4108FN7 Aldo keto reductase S101392_01045 ENOG4105F6E Acyl-transferase S101392_01046 ENOG4105C37 (CBS) domain S101392_01048 ENOG4105CHM Aminotransferase S101392_01049 ENOG4105C37 (CBS) domain S101392_01051 ENOG4105WMR Protein CrcB homolog S101392_01052 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S101392_01054 ENOG4105D64 Mechanosensitive ion channel S101392_01055 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) S101392_01056 ENOG4107VMI polysaccharide deacetylase S101392_01057 ENOG4105F0I Aminotransferase S101392_01060 ENOG4105BZ1 (ABC) transporter S101392_01061 ENOG4105BZ1 (ABC) transporter S101392_01065 ENOG410839P S101392_01067 ENOG4106MP8 UPF0754 membrane protein S101392_01068 ENOG4105WZB UPF0342 protein S101392_01069 ENOG4105F1N DNA alkylation repair S101392_01071 ENOG4105D4P Coproporphyrinogen iii oxidase S101392_01072 ENOG4107S91 Sodium hydrogen exchanger S101392_01073 ENOG4105NCW Trka-c domain protein S101392_01075 ENOG4105CGU Enoyl-CoA hydratase S101392_01077 ENOG4108IUX (ABC) transporter S101392_01078 ENOG4105RHA ABC transporter, permease S101392_01079 ENOG4107VRP DNA repair exonuclease S101392_01080 ENOG4106D4I domain protein S101392_01081 ENOG4105EQI Metal Dependent Phosphohydrolase S101392_01083 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) S101392_01088 ENOG4105NBU tryptophan transport protein S101392_01089 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) S101392_01090 ENOG4105K59 histidine triad (HIT) protein S101392_01097 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation S101392_01098 ENOG4105BZ4 penicillin-binding protein S101392_01099 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) S101392_01100 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) S101392_01101 ENOG4105C1Q protoporphyrinogen oxidase S101392_01103 ENOG4105ECB domain protein S101392_01105 ENOG41090T1 Membrane S101392_01106 ENOG4105DER m42 family S101392_01109 ENOG4108RQ5 Beta-lactamase domain-containing protein S101392_01110 ENOG4105DF9 Lipoate-protein, ligase S101392_01112 ENOG4105CEY Amp-dependent synthetase and ligase S101392_01114 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 S101392_01116 ENOG4105KD7 acetyltransferase S101392_01118 ENOG4108HUF Transporter S101392_01119 ENOG4107TB6 phosphoglycerate mutase S101392_01121 ENOG4107F3J Amp-dependent synthetase and ligase S101392_01122 ENOG4107ZYJ bioY protein S101392_01123 ENOG4106YBV Methyl-accepting chemotaxis S101392_01127 ENOG4105XVF Competence transcription factor S101392_01128 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S101392_01129 ENOG4105X3H Excalibur domain protein S101392_01130 ENOG4105E1V na solute symporter S101392_01131 ENOG4106CAD Protein of unknown function (DUF3311) S101392_01132 ENOG41060YP S101392_01135 ENOG4107SCK Monooxygenase S101392_01136 ENOG4108INS Transcriptional regulator S101392_01139 ENOG4105TRI Hydrolase S101392_01142 ENOG4108KK1 membrane protein AbrB duplication S101392_01143 ENOG4106K7D Major facilitator family transporter S101392_01144 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) S101392_01147 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation S101392_01149 ENOG4105EYH Exonuclease S101392_01159 ENOG4105ERH Fumarylacetoacetate hydrolase S101392_01161 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101392_01163 ENOG4105CAQ asparagine synthetase S101392_01166 ENOG4105UQX Mate efflux family protein S101392_01167 ENOG4106HBX Transcriptional Regulator AraC Family S101392_01168 ENOG4105ETE Transcriptional regulator (LacI family S101392_01170 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S101392_01171 ENOG4105SF0 DinB family S101392_01172 ENOG4108ZUB Lysine exporter protein (Lyse ygga) S101392_01173 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101392_01174 ENOG4105MYW Pentapeptide repeat protein S101392_01175 ENOG4107S9D Alpha beta hydrolase S101392_01176 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) S101392_01177 ENOG4107RIQ Sulfate adenylate transferase S101392_01178 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) S101392_01179 ENOG4108N5B 2-phosphosulfolactate phosphatase S101392_01180 ENOG41061P3 phosphosulfolactate synthase S101392_01182 ENOG4105DIA mandelate racemase muconate lactonizing S101392_01183 ENOG4107RCC Major Facilitator Superfamily S101392_01184 ENOG4108SZE gCN5-related N-acetyltransferase S101392_01185 ENOG4105MA6 gCN5-related N-acetyltransferase S101392_01187 ENOG4108VPT UPF0234 protein S101392_01188 ENOG4105QNR S1 RNA binding domain protein S101392_01192 ENOG4105K7K Transcriptional regulator S101392_01194 ENOG410751J S101392_01195 ENOG4105D4Y metalloprotease S101392_01196 ENOG4105EPR degv family S101392_01197 ENOG4107AYK membrAne S101392_01199 ENOG41073B9 S101392_01201 ENOG4108KP7 hydrolase S101392_01202 ENOG4108MXZ Esterase S101392_01203 ENOG4105VG1 fes assembly suf system protein S101392_01205 ENOG4105IQ5 FAD linked oxidase domain protein S101392_01207 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase S101392_01210 ENOG4105C8Y Acetylornithine aminotransferase S101392_01211 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S101392_01213 ENOG4105DBV ornithine carbamoyltransferase S101392_01218 ENOG4107RMD Basic membrane lipoprotein S101392_01221 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) S101392_01222 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) S101392_01224 ENOG4105C3U ABC transporter S101392_01225 ENOG4108JQ7 (ABC) transporter S101392_01228 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101392_01230 ENOG4105C31 Tryptophanyl-tRNA synthetase S101392_01231 ENOG4108J59 Extracellular solute-binding protein, family 5 S101392_01232 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S101392_01233 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101392_01235 ENOG4108JQ7 (ABC) transporter S101392_01238 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) S101392_01239 ENOG4108ZCF integral membrane protein S101392_01240 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis S101392_01242 ENOG4105DPN Oligoendopeptidase f S101392_01245 ENOG4105T58 Dithiol-disulfide isomerase S101392_01246 ENOG4108Z18 K06886 hemoglobin S101392_01247 ENOG4105E4C Lytic transglycosylase catalytic S101392_01248 ENOG4105MIX Adenylate cyclase S101392_01251 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) S101392_01252 ENOG4105EMS pseudouridine synthase S101392_01255 ENOG4105ETU transcriptional activator (TenA S101392_01256 ENOG4108VEU Thiamine monophosphate synthase S101392_01259 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) S101392_01260 ENOG4105D06 uba thif-type nad fad binding protein S101392_01261 ENOG4105DWF phosphomethylpyrimidine kinase S101392_01262 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH S101392_01263 ENOG4107A88 S101392_01273 ENOG4105ENA helicase S101392_01276 ENOG4108ZMI UPF0477 protein S101392_01278 ENOG4105C28 cystathionine S101392_01279 ENOG4105C28 cystathionine S101392_01280 ENOG4105D9U N-acetyltransferase S101392_01281 ENOG4105JHY Membrane S101392_01284 ENOG4106BHF S101392_01289 ENOG4108PSK reductase S101392_01292 ENOG4105DM4 PTS System S101392_01293 ENOG4105DG6 mannose-6-phosphate isomerase S101392_01294 ENOG4105G7B Protein of unknown function (DUF2992) S101392_01295 ENOG4105VMI -acetyltransferase S101392_01296 ENOG4108Z66 YbaK ebsC protein S101392_01299 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) S101392_01301 ENOG4108ZJ4 polysaccharide deacetylase S101392_01302 ENOG4107CUJ Protein of unknown function (DUF2690) S101392_01307 ENOG4108IEG Formate dehydrogenase Alpha subunit S101392_01312 ENOG4106A3M Cytochrome p-450 S101392_01313 ENOG41087PP glycosyltransferase MGT family S101392_01315 ENOG4105EXQ uroporphyrinogen iii synthase hem4 S101392_01316 ENOG4105C4B ABC transporter, permease S101392_01317 ENOG4108IXI (ABC) transporter S101392_01319 ENOG4105Q95 Cupin 2, conserved barrel domain protein S101392_01322 ENOG4105D2H Uronic isomerase S101392_01323 ENOG4105CT4 transporter S101392_01324 ENOG4105DG4 malate L-lactate dehydrogenase S101392_01325 ENOG4105CPQ Dehydrogenase S101392_01326 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) S101392_01327 ENOG4105DMW Dehydrogenase reductase S101392_01328 ENOG4108I5G Major Facilitator superfamily S101392_01329 ENOG4107KJX Transcriptional regulator S101392_01330 ENOG4107QZW Altronate oxidoreductase S101392_01331 ENOG4105CTX dehydratase S101392_01332 ENOG4107TSN permease S101392_01334 ENOG4105JD4 ATPase yjob S101392_01337 ENOG41068K0 YCII-related domain S101392_01338 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101392_01339 ENOG4105KWG Pfam:DUF1696 S101392_01340 ENOG4105K7W phage-related replication protein S101392_01341 ENOG4105WEF catalase S101392_01342 ENOG410635T phage-like element pbsx protein S101392_01352 ENOG4108TFU terminase (Small subunit) S101392_01353 ENOG4105IG6 Phage terminase, large subunit S101392_01354 ENOG4108MDF Phage Portal Protein S101392_01359 ENOG41060SN S101392_01361 ENOG4105PQS phage protein S101392_01362 ENOG4105FR7 XkdM protein, phage-like element PBSX S101392_01363 ENOG4105MTC XkdN-like protein S101392_01364 ENOG4108FKH Transglycosylase SLT domain S101392_01365 ENOG4108WZM domain protein S101392_01366 ENOG4105X7F S101392_01368 ENOG4105MFU Protein of unknown function (DUF2634) S101392_01369 ENOG41066EA baseplate J family protein S101392_01370 ENOG410906S phage-like element pbsx protein xkdt S101392_01372 ENOG41068G1 S101392_01378 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S101392_01382 ENOG4105CJ3 phosphate transporter S101392_01383 ENOG4107GRR phosphate transport regulator S101392_01384 ENOG4107R7I amino acid S101392_01386 ENOG4105EDW glycosyl transferase, family 39 S101392_01387 ENOG4105CKK Glycosyl transferase, family 2 S101392_01389 ENOG4105C0H protease S101392_01391 ENOG4108ME1 Peptidase M55 D-aminopeptidase S101392_01392 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S101392_01393 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101392_01394 ENOG4105C3U ABC transporter S101392_01397 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A S101392_01398 ENOG4105DTQ mandelate racemase muconate lactonizing S101392_01399 ENOG4107SN7 NLP P60 protein S101392_01400 ENOG4108JQ7 (ABC) transporter S101392_01401 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) S101392_01402 ENOG4107TUM Amidinotransferase S101392_01403 ENOG4108S4H thioesterase Superfamily protein S101392_01404 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) S101392_01408 ENOG4108428 Inherit from COG: -acetyltransferase S101392_01410 ENOG41080TC multidrug resistance protein S101392_01411 ENOG4105CIY formyltetrahydrofolate deformylase S101392_01412 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S101392_01415 ENOG4105K56 Transcriptional regulator S101392_01416 ENOG4108ZHJ Organic hydroperoxide resistance protein S101392_01418 ENOG4107Y2X deaminase S101392_01419 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) S101392_01420 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101392_01422 ENOG4108W7F transporter, permease S101392_01423 ENOG4108JJB ABC transporter S101392_01424 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein S101392_01425 ENOG4108X43 YKOF domain protein S101392_01426 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101392_01427 ENOG41062D9 Histidine kinase S101392_01429 ENOG4106849 propeptide, pepSY amd peptidase M4 S101392_01432 ENOG4105CJW magnesium transporter S101392_01433 ENOG4105V75 Transcriptional regulator S101392_01442 ENOG4105DQE DNA ligase S101392_01443 ENOG4105FDF Could be involved in DNA repair (By similarity) S101392_01444 ENOG4105BZU Histidine kinase S101392_01445 ENOG4107T5V SNARE associated Golgi S101392_01446 ENOG4107TS3 membrane protein, TerC S101392_01447 ENOG4108WZW RNA polymerase sigma S101392_01449 ENOG410681C small acid-soluble spore protein S101392_01451 ENOG4105D0M Protease HtpX homolog S101392_01455 ENOG4108TGC Acyltransferase S101392_01456 ENOG4105BZU Histidine kinase S101392_01457 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S101392_01459 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) S101392_01460 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) S101392_01461 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S101392_01463 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit S101392_01464 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) S101392_01465 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) S101392_01466 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) S101392_01470 ENOG4105BZU Histidine kinase S101392_01471 ENOG41090MY MarR family Transcriptional regulator S101392_01472 ENOG4105ER2 Ompa motb domain protein S101392_01473 ENOG4105E14 MotA TolQ exbB proton channel S101392_01475 ENOG4108K88 Membrane S101392_01476 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) S101392_01477 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase S101392_01478 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) S101392_01479 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) S101392_01481 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr S101392_01482 ENOG4105FEA Spore maturation protein S101392_01488 ENOG4105F0V Cell wall hydrolase S101392_01491 ENOG4105C59 p-type ATPase S101392_01493 ENOG4105DC7 peptidase M24 S101392_01496 ENOG4105CID antiterminator S101392_01498 ENOG4105KRI phosphocarrier protein (HPr S101392_01499 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) S101392_01501 ENOG4105F6S Spore photoproduct lyase S101392_01503 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer S101392_01504 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase S101392_01505 ENOG4105K4I Scp-like extracellular S101392_01507 ENOG4105BZU Histidine kinase S101392_01508 ENOG4105CHM Aminotransferase S101392_01510 ENOG4107R88 Chemotaxis protein (CheV) S101392_01511 ENOG4105UIN S101392_01513 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein S101392_01515 ENOG4105K6S Short-chain dehydrogenase reductase Sdr S101392_01516 ENOG4105EPM Diguanylate phosphodiesterase S101392_01517 ENOG4107IN1 Protein of unknown function (DUF1797) S101392_01518 ENOG4108XRC Protein of unknown function (DUF458) S101392_01524 ENOG4105NQC Flavodoxin S101392_01526 ENOG4105CH2 amidohydrolase S101392_01528 ENOG4105D8X mechanosensitive ion channel S101392_01529 ENOG4105D3R alkyl hydroperoxide reductase S101392_01530 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101392_01533 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) S101392_01534 ENOG4105D06 uba thif-type nad fad binding protein S101392_01535 ENOG4105CVM Molybdenum cofactor synthesis domain protein S101392_01536 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein S101392_01537 ENOG4108ZAF Molybdopterin S101392_01538 ENOG41067WU Molybdopterin converting factor (Subunit 1) S101392_01539 ENOG4105BZ1 (ABC) transporter S101392_01540 ENOG4105BZ1 (ABC) transporter S101392_01542 ENOG4107X8C Efflux transporter RND family MFP subunit S101392_01543 ENOG4105C19 ABC transporter S101392_01544 ENOG4107RBB ABC transporter, permease S101392_01545 ENOG4105E98 transcriptional regulator DeoR family S101392_01546 ENOG4105DE4 1-phosphofructokinase S101392_01547 ENOG4105DM4 PTS System S101392_01548 ENOG4105C3F Signal peptidase i S101392_01550 ENOG4105C5H ABC transporter S101392_01551 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) S101392_01556 ENOG4105BZU Histidine kinase S101392_01558 ENOG4107ZYR domain protein S101392_01560 ENOG4105CN5 Metallo-Beta-Lactamase S101392_01562 ENOG4108X4Q Hydrolase S101392_01563 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S101392_01567 ENOG4105CPP Dehydrogenase, E1 component S101392_01568 ENOG4105C7S Dehydrogenase S101392_01569 ENOG4107QN2 dihydrolipoyl dehydrogenase S101392_01572 ENOG4105CXN decarboxylase S101392_01573 ENOG4105WBI UPF0223 protein S101392_01576 ENOG4105ECY inositol monophosphatase S101392_01578 ENOG4105JQZ Methyltransferase S101392_01586 ENOG4105CI3 gtp-binding protein typa S101392_01587 ENOG4105QA2 S101392_01590 ENOG4108IAB Phoh family S101392_01592 ENOG4105CSV Glutaminase S101392_01593 ENOG4105ZPI UPF0358 protein S101392_01594 ENOG4105CNI cell division protein FtsW S101392_01595 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) S101392_01597 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) S101392_01599 ENOG4105BZ9 Cytochrome C oxidase, subunit I S101392_01600 ENOG4105CCU oxidase (Subunit III) S101392_01601 ENOG41064X9 cytochrome C oxidase subunit IV S101392_01604 ENOG41080XQ Signal transduction protein with cbs domains S101392_01605 ENOG4106UY4 Inherit from COG: Scp-like extracellular S101392_01609 ENOG4105WUC UPF0298 protein S101392_01610 ENOG4106H78 methyltransferase S101392_01611 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) S101392_01612 ENOG4105H20 Sporulation integral membrane protein YlbJ S101392_01613 ENOG4105D78 K07001 NTE family protein S101392_01614 ENOG41063PX domain protein S101392_01615 ENOG4105CDE UPF0348 protein S101392_01617 ENOG4105KNH Nucleic acid-binding protein S101392_01618 ENOG41067VY 50S ribosomal protein L32 S101392_01623 ENOG4108V6E Cell division protein mraZ S101392_01624 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) S101392_01626 ENOG4105CJN penicillin-binding protein S101392_01627 ENOG4105CJN penicillin-binding protein S101392_01628 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) S101392_01629 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) S101392_01630 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) S101392_01631 ENOG4105CNI cell division protein FtsW S101392_01632 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) S101392_01633 ENOG4105D4A Cell wall formation (By similarity) S101392_01634 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) S101392_01635 ENOG4108R2U division initiation protein S101392_01637 ENOG4105K67 small basic protein S101392_01638 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) S101392_01639 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) S101392_01641 ENOG4105FFI sigma-e processing peptidase spoiiga S101392_01642 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101392_01644 ENOG4105DKW ABC transporter S101392_01646 ENOG4105WR5 sporulation protein, YlmC YmxH family S101392_01647 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase S101392_01648 ENOG4105DFA alanine racemase domain protein S101392_01649 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) S101392_01650 ENOG41067XK integral membrane protein S101392_01651 ENOG4105DBK s4 domain protein S101392_01653 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) S101392_01655 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) S101392_01656 ENOG4105C34 Pseudouridine synthase S101392_01657 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) S101392_01659 ENOG4105CXT aspartate transcarbamylase S101392_01661 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S101392_01662 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain S101392_01663 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) S101392_01664 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) S101392_01665 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) S101392_01666 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) S101392_01667 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) S101392_01669 ENOG4107S4M Sulfate adenylate transferase S101392_01670 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) S101392_01671 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S101392_01672 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein S101392_01673 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein S101392_01674 ENOG4105F23 Fibronectin-binding protein S101392_01676 ENOG4105DSJ YicC domain protein S101392_01677 ENOG4105KC4 UPF0296 protein S101392_01678 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) S101392_01680 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase S101392_01681 ENOG4105C25 Primosomal protein n' S101392_01682 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S101392_01683 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) S101392_01684 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B S101392_01685 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs S101392_01686 ENOG4108ZF3 Phosphatase S101392_01687 ENOG4105D9P serine threonine protein kinase S101392_01688 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) S101392_01689 ENOG4105DJV ribulose-phosphate 3-epimerase S101392_01690 ENOG4105FJ0 thiamine S101392_01691 ENOG4105VB9 50S ribosomal protein l28 S101392_01692 ENOG4108ZAA Alkaline-shock protein S101392_01693 ENOG4105DP4 dak2 domain fusion protein ylov S101392_01695 ENOG4105EJQ L-serine dehydratase S101392_01696 ENOG4105CB5 ATP-dependent DNA helicase recG S101392_01697 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) S101392_01699 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase S101392_01700 ENOG4105CHR reductase S101392_01701 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) S101392_01702 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) S101392_01703 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) S101392_01704 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) S101392_01706 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) S101392_01708 ENOG4105K5M 30s ribosomal protein S16 S101392_01709 ENOG4108BW8 UPF0109 protein S101392_01711 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) S101392_01712 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) S101392_01713 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) S101392_01714 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) S101392_01715 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S101392_01717 ENOG4105VM1 flagellar S101392_01718 ENOG4105CMV Succinyl-CoA synthetase subunit beta S101392_01719 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha S101392_01720 ENOG4105C79 DNA protecting protein DprA S101392_01721 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) S101392_01722 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) S101392_01723 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101392_01724 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) S101392_01725 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) S101392_01727 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) S101392_01728 ENOG4108ZC9 flagellar basal-body rod protein flgc S101392_01729 ENOG4105VQ0 flagellar hook-basal body complex protein fliE S101392_01730 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) S101392_01731 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S101392_01734 ENOG4106YF4 Flagellar biosynthesis chaperone S101392_01736 ENOG410696Y Flagellar hook-length control protein S101392_01737 ENOG410822I Flagellar hook capping protein S101392_01738 ENOG4108JQA flagellar S101392_01740 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S101392_01741 ENOG4105DD5 Flagellar motor switch protein S101392_01742 ENOG4107YTP response regulator receiver protein S101392_01744 ENOG4105CN7 Flagellar biosynthetic protein FliP S101392_01745 ENOG4105VS8 Flagellar biosynthetic protein fliq S101392_01746 ENOG4105D19 Role in flagellar biosynthesis (By similarity) S101392_01747 ENOG4105D00 flagellar biosynthetic protein flhB S101392_01748 ENOG4105D7B Flagellar biosynthesis protein flha S101392_01749 ENOG4105FZW flagellar biosynthesis regulator FlhF S101392_01751 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) S101392_01752 ENOG4105CBS Chea signal transduction histidine kinase S101392_01753 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis S101392_01756 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101392_01758 ENOG4105CE9 30S ribosomal protein S2 S101392_01759 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) S101392_01761 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) S101392_01762 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) S101392_01763 ENOG4105KNE Phosphatidate cytidylyltransferase S101392_01765 ENOG4105DZP Membrane-associated zinc metalloprotease S101392_01766 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) S101392_01767 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) S101392_01768 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) S101392_01769 ENOG4105CHV Transcription elongation factor NusA S101392_01770 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination S101392_01771 ENOG4105VHM ribosomal protein S101392_01772 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) S101392_01773 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) S101392_01774 ENOG4105W7A Protein of unknown function (DUF503) S101392_01775 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) S101392_01776 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) S101392_01777 ENOG4105DTN riboflavin biosynthesis protein ribF S101392_01778 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) S101392_01779 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) S101392_01781 ENOG4105C1V Peptidase, M16 S101392_01783 ENOG4105E35 Dipicolinate synthase subunit A S101392_01784 ENOG4108S0H Dipicolinic acid synthetase, b subunit S101392_01785 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) S101392_01787 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) S101392_01789 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit S101392_01791 ENOG4105CNU cell division protein FtsK S101392_01792 ENOG4105FDP GntR family transcriptional regulator S101392_01796 ENOG4108RKS Short-chain dehydrogenase reductase Sdr S101392_01797 ENOG4105XZV Protein of unknown function (DUF3243) S101392_01800 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase S101392_01801 ENOG4105CEV competence damage-inducible protein S101392_01803 ENOG4108A04 Beta-lactamase S101392_01804 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) S101392_01805 ENOG4105D48 metallophosphoesterase S101392_01806 ENOG4105MCT stage V sporulation protein S S101392_01808 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S101392_01809 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S101392_01812 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) S101392_01813 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) S101392_01816 ENOG4105IIP Membrane S101392_01817 ENOG4105W1N transcriptional regulator S101392_01818 ENOG4108151 Beta-lactamase domain protein S101392_01819 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase S101392_01822 ENOG4107QKG PfaD family S101392_01823 ENOG41062T2 Acyl carrier protein S101392_01824 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase S101392_01825 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase S101392_01826 ENOG4108MGH Enoyl-CoA hydratase S101392_01827 ENOG4108KQ6 Enoyl-CoA hydratase S101392_01828 ENOG4105C0W non-ribosomal peptide synthetase S101392_01829 ENOG4107SQU synthase S101392_01831 ENOG4105C0W non-ribosomal peptide synthetase S101392_01833 ENOG4106A3M Cytochrome p-450 S101392_01836 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101392_01838 ENOG4105K7W phage-related replication protein S101392_01839 ENOG4108X3M OsmC Ohr family protein S101392_01840 ENOG410814C multidrug resistance protein S101392_01844 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) S101392_01845 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) S101392_01848 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) S101392_01849 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101392_01850 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101392_01851 ENOG4105U6W MutT NUDIX family protein S101392_01852 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101392_01853 ENOG4106F1P AAA ATPase, central domain protein S101392_01854 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) S101392_01855 ENOG4105CXI aluminum resistance protein S101392_01856 ENOG4105KV4 Transcriptional regulator S101392_01857 ENOG4105C5F glutamine synthetase S101392_01864 ENOG4108ZUE Phage regulatory protein rha S101392_01869 ENOG4105CDU Replicative dna helicase S101392_01888 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S101392_01898 ENOG4108FKH Transglycosylase SLT domain S101392_01900 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S101392_01901 ENOG410651K Teichoic acid biosynthesis protein C S101392_01904 ENOG41068G1 S101392_01908 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101392_01910 ENOG4106BHF S101392_01911 ENOG410780I phosphoprotein phosphatase activity S101392_01915 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101392_01920 ENOG4107VRI Transcriptional regulator S101392_01956 ENOG4108FKH Transglycosylase SLT domain S101392_01959 ENOG410651K Teichoic acid biosynthesis protein C S101392_01960 ENOG41068G1 S101392_01964 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101392_01973 ENOG4106WTF Glycosyl transferase, family 2 S101392_01974 ENOG4107RGC Glycosyl transferase, family 2 S101392_01981 ENOG4107NTZ S101392_01984 ENOG410907G S101392_01985 ENOG4105CT4 transporter S101392_01986 ENOG4105DSG hydrolase family 43 S101392_01987 ENOG4105E2R ROK family S101392_01988 ENOG4105C93 Xylose Isomerase S101392_01989 ENOG4105CMG Carbohydrate kinase S101392_01990 ENOG4107Y9E nuclease S101392_01991 ENOG4105C54 Major Facilitator superfamily S101392_01992 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S101392_01994 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) S101392_02009 ENOG4108Q8B Spore germination protein S101392_02010 ENOG4108NHD germination protein S101392_02013 ENOG4105FVX S101392_02015 ENOG4105K7W phage-related replication protein S101392_02017 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) S101392_02018 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) S101392_02020 ENOG4108SVB resolvase S101392_02021 ENOG4105VPS UPF0291 protein S101392_02022 ENOG4105CV1 Transketolase (EC 2.2.1.1) S101392_02026 ENOG4107QIV Cytochrome c biogenesis protein S101392_02031 ENOG4107DZX Small, acid-soluble spore protein P S101392_02033 ENOG4108I0Z Aconitate hydratase S101392_02034 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101392_02037 ENOG41067CD Small, acid-soluble spore protein Tlp S101392_02039 ENOG4105MI2 S101392_02040 ENOG4105W8X HesB YadR YfhF-family protein S101392_02041 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) S101392_02042 ENOG4105K4P CoA-binding domain protein S101392_02043 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S101392_02048 ENOG4107QWR cellulase (EC 3.2.1.4) S101392_02050 ENOG4108MYR Secreted protein S101392_02051 ENOG4107SYN Glycosyl hydrolases family 43 S101392_02053 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S101392_02054 ENOG4107T5V SNARE associated Golgi S101392_02056 ENOG4107QX3 carboxylase S101392_02057 ENOG4105E39 Enoyl-CoA hydratase S101392_02058 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase S101392_02059 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit S101392_02060 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S101392_02061 ENOG4105CEY Amp-dependent synthetase and ligase S101392_02062 ENOG4105C1G acyl-Coa dehydrogenase S101392_02063 ENOG4105F32 YngK protein S101392_02064 ENOG4106U2H Protein of unknown function (DUF1360) S101392_02066 ENOG4105CEY Amp-dependent synthetase and ligase S101392_02067 ENOG4105C0W non-ribosomal peptide synthetase S101392_02069 ENOG4105C0W non-ribosomal peptide synthetase S101392_02070 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family S101392_02071 ENOG4108N2V aldose 1-epimerase S101392_02072 ENOG4107QJQ Mate efflux family protein S101392_02077 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S101392_02078 ENOG4105SKE transcriptional Regulator LysR family S101392_02079 ENOG4105CB2 alcohol dehydrogenase S101392_02080 ENOG4105BZ8 glutamate synthase S101392_02081 ENOG4105CBC glutamate synthase S101392_02082 ENOG4105C5Q Transcriptional regulator S101392_02083 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S101392_02084 ENOG4105II7 pyrroline-5-carboxylate reductase S101392_02088 ENOG4108UB7 S101392_02089 ENOG41068WN S101392_02090 ENOG4105IE8 Alpha-ketoglutarate permease S101392_02091 ENOG4107U6E carbohydrate kinase FGGY S101392_02092 ENOG4108M3J Dehydrogenase S101392_02093 ENOG4108J2R molybdopterin oxidoreductase S101392_02098 ENOG4105EC8 Methyl-accepting chemotaxis S101392_02100 ENOG4108YQE rare lipoprotein a S101392_02101 ENOG4105XPP Protein of unknown function (DUF1275) S101392_02102 ENOG4108NR7 pectate lyase S101392_02103 ENOG4108RAV Conserved protein S101392_02105 ENOG4105F0F Oxalate decarboxylase S101392_02107 ENOG4105EPI acetyltransferase, (GNAT) family S101392_02111 ENOG41073R8 VanW family S101392_02113 ENOG4105VMP Transcriptional regulator S101392_02114 ENOG4105NX3 Membrane S101392_02116 ENOG4108Q5Y Membrane S101392_02118 ENOG4108V4B ThiJ pfpI S101392_02119 ENOG4108J4B Beta-lactamase S101392_02123 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S101392_02124 ENOG4107T94 Endo-14-beta-xylanase S101392_02125 ENOG4105YB8 TM2 domain containing protein S101392_02126 ENOG4108IMY Transcriptional regulator S101392_02132 ENOG4108J9Q DNA ligase S101392_02145 ENOG410780I phosphoprotein phosphatase activity S101392_02147 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S101392_02148 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S101392_02153 ENOG4106BHF S101392_02156 ENOG4108Z7R Chaperone CsaA S101392_02157 ENOG4105FTV AraC Family Transcriptional Regulator S101392_02158 ENOG4108HJF gCN5-related N-acetyltransferase S101392_02160 ENOG4108W8B Beta-lactamase domain protein S101392_02162 ENOG4105D29 Helix-turn-helix type 11 domain protein S101392_02164 ENOG4105KTU Transcriptional regulator, arsr family S101392_02166 ENOG4108SJC Membrane S101392_02170 ENOG4105ECK Fatty Acid Desaturase S101392_02171 ENOG4108ZGX Histidine kinase S101392_02172 ENOG4108S01 response regulator S101392_02174 ENOG41069ER domain protein S101392_02175 ENOG4105C9U ATP-dependent DNA helicase RecQ S101392_02176 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) S101392_02177 ENOG4105SCY DNAK suppressor S101392_02185 ENOG4105C26 Dehydrogenase S101392_02186 ENOG4105EWU Squalene--hopene cyclase S101392_02187 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S101392_02188 ENOG4105C8J )-transporter S101392_02189 ENOG4105C09 Bile acid S101392_02190 ENOG4105C7S Dehydrogenase S101392_02192 ENOG4107T89 von Willebrand factor, type A S101392_02193 ENOG4105GMT ATPase associated with various cellular activities aaa_5 S101392_02195 ENOG4105K4H Nlp p60 protein S101392_02196 ENOG41087PP glycosyltransferase MGT family S101392_02199 ENOG4107QMU Mate efflux family protein S101392_02200 ENOG4106SCS STAS domain S101392_02204 ENOG4105FR1 rard protein S101392_02207 ENOG4105C6Z Gluconate S101392_02208 ENOG41090U3 tautomerase S101392_02211 ENOG4105FBA Phospholipase Carboxylesterase S101392_02214 ENOG4105E1V na solute symporter S101392_02218 ENOG4108VXD carboxy-peptidase S101392_02219 ENOG4105D3A purine nucleoside phosphorylase DeoD-type S101392_02221 ENOG4106Z5R S101392_02222 ENOG410841Q phosphoesterase PA-phosphatase related protein S101392_02228 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein S101392_02229 ENOG4108TSC N-acetyltransferase S101392_02230 ENOG4107S4Y M20 DapE family protein YgeY S101392_02233 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S101392_02240 ENOG4107T32 3-phytase (EC 3.1.3.8) S101392_02241 ENOG4105C5E polysaccharide biosynthesis protein S101392_02242 ENOG4105E0X reductase S101392_02243 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) S101392_02247 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) S101392_02248 ENOG41090WU lipolytic protein G-D-S-L family S101392_02249 ENOG4108KF3 Electron transport protein SCO1 SenC S101392_02251 ENOG4105C7B Threonine dehydratase S101392_02253 ENOG4108UT2 hemolysin iii S101392_02255 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) S101392_02256 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) S101392_02259 ENOG4107YX5 Pfam:DUF548 S101392_02260 ENOG4108Y6J UPF0403 protein S101392_02261 ENOG4105C01 Dihydroxy-acid dehydratase S101392_02264 ENOG4108V06 Glutathione peroxidase S101392_02265 ENOG4105CVG Homoserine O-transsuccinylase S101392_02274 ENOG41081VK Ribonuclease S101392_02279 ENOG410890F Dynamin family S101392_02282 ENOG41065KQ synthase S101392_02283 ENOG4105C2W permease S101392_02284 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) S101392_02285 ENOG4105CTD carboxy-peptidase S101392_02286 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) S101392_02287 ENOG4108UHU Aldolase S101392_02288 ENOG4105D7K pfkb domain protein S101392_02289 ENOG4108M60 Transcriptional regulator S101392_02291 ENOG4105CHR reductase S101392_02292 ENOG4105DVT helicase S101392_02294 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) S101392_02296 ENOG4108UKS UPF0398 protein S101392_02297 ENOG4107X2U Inherit from COG: Exonuclease-like protein S101392_02298 ENOG4108I5C dEAD DEAH box helicase S101392_02308 ENOG4105BZ4 penicillin-binding protein S101392_02310 ENOG4105CSM endonuclease III S101392_02312 ENOG4105C5S asparaginyl-tRNA synthetase S101392_02313 ENOG4105CHM Aminotransferase S101392_02315 ENOG4105YAC S101392_02316 ENOG4105DVT helicase S101392_02317 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) S101392_02318 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) S101392_02319 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) S101392_02320 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase S101392_02321 ENOG4105DJ0 Poly(A) Polymerase S101392_02322 ENOG4105CPK Glycosyl transferase (Group 1 S101392_02323 ENOG4105FJR Lmbe family S101392_02324 ENOG4108Z5K methylglyoxal synthase S101392_02325 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) S101392_02326 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase S101392_02327 ENOG4108JYZ YitT family S101392_02331 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) S101392_02335 ENOG41068YB TPR repeat-containing protein S101392_02336 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase S101392_02338 ENOG4105CIH Imidazole acetol-phosphate transaminase S101392_02340 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) S101392_02341 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase S101392_02343 ENOG4108I0Q anthranilate phosphoribosyltransferase S101392_02344 ENOG4105CRQ synthase (Component I) S101392_02345 ENOG4105KHN chorismate mutase S101392_02346 ENOG4105D49 3-dehydroquinate synthase S101392_02347 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase S101392_02348 ENOG4105BZU Histidine kinase S101392_02349 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) S101392_02350 ENOG4105EAH synthase S101392_02351 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) S101392_02352 ENOG4105XXQ heptaprenyl diphosphate synthase component I S101392_02354 ENOG4105EUJ GTP cyclohydrolase i S101392_02355 ENOG4105K70 DNA-binding protein S101392_02356 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) S101392_02359 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase S101392_02360 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) S101392_02361 ENOG41065D1 S101392_02362 ENOG4105S2F S101392_02365 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) S101392_02366 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) S101392_02367 ENOG4105CAT Cytidine monophosphate kinase S101392_02370 ENOG4105MSI germination protein ypeb S101392_02372 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) S101392_02373 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase S101392_02376 ENOG4107RGJ metallophosphoesterase S101392_02379 ENOG4105I7S Abortive infection protein S101392_02380 ENOG4105C9U ATP-dependent DNA helicase RecQ S101392_02381 ENOG4105T7X S101392_02383 ENOG4108SAX Membrane S101392_02384 ENOG4108JQ1 Dehydrogenase S101392_02385 ENOG4105FF2 Type I DHQase S101392_02388 ENOG4105BZU Histidine kinase S101392_02389 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101392_02390 ENOG4105CRE cytochrome C S101392_02391 ENOG4107TWT Cytochrome c biogenesis protein S101392_02393 ENOG4105FE9 pseudouridine synthase S101392_02395 ENOG4108JIC nucleoside recognition domain protein S101392_02396 ENOG4105DZ1 carboxypeptidase S101392_02398 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) S101392_02399 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) S101392_02402 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) S101392_02403 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) S101392_02404 ENOG4108R6K riboflavin synthase, subunit alpha S101392_02405 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) S101392_02407 ENOG4105C3F Signal peptidase i S101392_02408 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) S101392_02413 ENOG4107ZE5 PPIases accelerate the folding of proteins S101392_02414 ENOG4105PTM secreted protein S101392_02415 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) S101392_02417 ENOG4105G6R Stage v sporulation protein ae S101392_02419 ENOG4105CZ3 stage V sporulation protein ad S101392_02420 ENOG41090VF Stage v sporulation protein ac S101392_02423 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101392_02424 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) S101392_02425 ENOG41082AN stage II sporulation protein S101392_02426 ENOG4105DZ1 carboxypeptidase S101392_02427 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) S101392_02428 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) S101392_02429 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101392_02431 ENOG4105I3K Ferric uptake regulator, Fur family S101392_02432 ENOG4105MZ9 stage II sporulation protein m S101392_02435 ENOG4105DFD Na H antiporter S101392_02436 ENOG4108IJ0 Aspartate ammonia-lyase S101392_02437 ENOG4105HDK L-asparaginase S101392_02438 ENOG4108IMY Transcriptional regulator S101392_02440 ENOG4108YZ4 nudix hydrolase S101392_02442 ENOG4105CPC Aldo Keto reductase S101392_02446 ENOG4106HZJ S101392_02447 ENOG4105RHY Pfam:UPF0157 S101392_02448 ENOG4105KAC Antibiotic biosynthesis monooxygenase S101392_02449 ENOG4108XET gCN5-related N-acetyltransferase S101392_02451 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S101392_02453 ENOG4105E5W Transporter S101392_02455 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase S101392_02458 ENOG4108IXY short-chain dehydrogenase reductase S101392_02459 ENOG41069FQ Metallo-beta-lactamase superfamily S101392_02460 ENOG4105II7 pyrroline-5-carboxylate reductase S101392_02462 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S101392_02464 ENOG410861F 50S ribosomal protein L33 S101392_02465 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) S101392_02466 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase S101392_02467 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) S101392_02468 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S101392_02470 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) S101392_02475 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) S101392_02477 ENOG4105CHR reductase S101392_02478 ENOG4105C84 Histidine ammonia-lyase S101392_02481 ENOG4108NA0 Uncharacterized conserved protein (COG2071) S101392_02482 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S101392_02483 ENOG4108HNZ carboxyl transferase S101392_02484 ENOG4108ZVT methylmalonyl-coA epimerase S101392_02486 ENOG4108VZI ErfK ybiS ycfS ynhG family protein S101392_02487 ENOG4108QEG Membrane S101392_02488 ENOG4105CDA abc transporter atp-binding protein S101392_02489 ENOG4105E5Q amino acid AbC transporter S101392_02490 ENOG4108HW3 (ABC) transporter S101392_02491 ENOG4108Y6J UPF0403 protein S101392_02492 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) S101392_02495 ENOG4105C7S Dehydrogenase S101392_02496 ENOG4105CPP Dehydrogenase, E1 component S101392_02499 ENOG4105CKM Branched-chain carboxylic acid kinase S101392_02500 ENOG4107RDP Dehydrogenase S101392_02502 ENOG4108JUB Transcriptional regulator S101392_02503 ENOG4106CCJ Protein of unknown function (DUF2627) S101392_02504 ENOG4105CR4 methylisocitrate lyase S101392_02505 ENOG4105DXD 2-methylcitrate dehydratase S101392_02507 ENOG4105C1G acyl-Coa dehydrogenase S101392_02508 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase S101392_02510 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S101392_02511 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101392_02513 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S101392_02514 ENOG4107QQR Sporulation S101392_02515 ENOG4105S1Z Stage IV sporulation protein B S101392_02516 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) S101392_02517 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) S101392_02518 ENOG4105DX0 Hemolysin A S101392_02520 ENOG4105CTB Polyprenyl synthetase S101392_02521 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S101392_02522 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S101392_02523 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) S101392_02524 ENOG4105M7K Involved in the transcription termination process (By similarity) S101392_02525 ENOG4108ZSR alkaline shock protein S101392_02526 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S101392_02530 ENOG410644B Stage III sporulation protein af S101392_02532 ENOG4105KQ4 Stage iii sporulation protein ad S101392_02533 ENOG4108CQH stage III sporulation protein AC S101392_02534 ENOG4105KR5 Stage iii sporulation protein S101392_02535 ENOG4105CD2 stage iii sporulation protein aa S101392_02537 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) S101392_02538 ENOG4105DC7 peptidase M24 S101392_02539 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) S101392_02541 ENOG4105CBJ Metal-dependent enzyme S101392_02544 ENOG4105KST dependent repressor S101392_02545 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) S101392_02546 ENOG4105WZW rhodanese family S101392_02547 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor S101392_02548 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor S101392_02549 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) S101392_02550 ENOG4105C0D helicase S101392_02553 ENOG4108IMY Transcriptional regulator S101392_02555 ENOG4105VFR signal peptidase S101392_02569 ENOG4105C37 (CBS) domain S101392_02574 ENOG4105C5X domain protein S101392_02579 ENOG4105E0M Sulfatase S101392_02582 ENOG4107ZXI Rhomboid family S101392_02584 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase S101392_02585 ENOG4105WDJ 50S ribosomal protein L33 S101392_02589 ENOG41068DG YceG-like family S101392_02590 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S101392_02591 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S101392_02592 ENOG4105E2Z phosphate ABC transporter (Permease S101392_02593 ENOG4105C8U phosphate abc transporter S101392_02594 ENOG4105CVA phosphate S101392_02595 ENOG4107RF6 penicillin-binding protein S101392_02597 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S101392_02598 ENOG4105SXS Protein of unknown function (DUF456) S101392_02601 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) S101392_02602 ENOG41063Y9 S101392_02603 ENOG4108U5J '-nucleotidase S101392_02604 ENOG4105N80 Ferric uptake regulator, Fur family S101392_02605 ENOG4108JYZ YitT family S101392_02606 ENOG41069ZM Protein of unknown function (DUF2624) S101392_02607 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) S101392_02610 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) S101392_02611 ENOG4105EGD dinuclear metal center protein, YbgI family S101392_02614 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101392_02615 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) S101392_02616 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 S101392_02617 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) S101392_02619 ENOG4105C38 Glycyl-tRNA synthetase beta subunit S101392_02620 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit S101392_02621 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) S101392_02623 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) S101392_02624 ENOG4105KG3 cytidine deaminase S101392_02625 ENOG4107YR5 Diacylglycerol kinase S101392_02626 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) S101392_02627 ENOG4105CTJ Metal Dependent Phosphohydrolase S101392_02629 ENOG4105C9A Phoh family S101392_02630 ENOG4105EI1 sporulation protein yqfd S101392_02631 ENOG41068P3 sporulation protein YqfC S101392_02633 ENOG4105DI5 UPF0365 protein S101392_02634 ENOG4105F7J membrane-bound serine protease S101392_02635 ENOG4105KTH gatB Yqey S101392_02638 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S101392_02639 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) S101392_02640 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) S101392_02642 ENOG4105CFG Acts as a chaperone (By similarity) S101392_02643 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ S101392_02644 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) S101392_02645 ENOG4105CSA Coproporphyrinogen iii oxidase S101392_02646 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) S101392_02648 ENOG4108ZRV stage ii sporulation protein p S101392_02649 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) S101392_02650 ENOG41082YS Binds directly to 16S ribosomal RNA S101392_02651 ENOG4105TQK DNA polymerase iii, delta' subunit S101392_02652 ENOG4105TQK DNA polymerase iii, delta' subunit S101392_02654 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 S101392_02655 ENOG4108UK2 deaminase S101392_02656 ENOG4105KQC Competence protein S101392_02658 ENOG4108D32 Methyltransferase S101392_02659 ENOG4108D32 Methyltransferase S101392_02661 ENOG4108WF2 Metal Dependent Phosphohydrolase S101392_02662 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) S101392_02663 ENOG410812S Rna-binding protein S101392_02664 ENOG4105E2X shikimate dehydrogenase S101392_02665 ENOG4105CQW ribosome biogenesis GTPase YqeH S101392_02666 ENOG4105CQW ribosome biogenesis GTPase YqeH S101392_02667 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase S101392_02670 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S101392_02671 ENOG41080BT SNARE associated Golgi S101392_02674 ENOG4105WFK nuclease S101392_02675 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101392_02677 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101392_02678 ENOG4107Y5K Resolvase S101392_02679 ENOG4105D3P Mannan endo-1,4-beta-mannosidase S101392_02688 ENOG4106BHF S101392_02689 ENOG4106ANW SMI1_KNR4 S101392_02691 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101392_02692 ENOG4105IG6 Phage terminase, large subunit S101392_02701 ENOG4105QBX endodeoxyribonuclease RusA S101392_02707 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) S101392_02708 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101392_02711 ENOG4105D3P Mannan endo-1,4-beta-mannosidase S101392_02712 ENOG41087NI Sulfite exporter TauE/SafE S101392_02713 ENOG4105VFE sira family S101392_02714 ENOG4107TPS domain protein S101392_02715 ENOG4105VFE sira family S101392_02716 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase S101392_02717 ENOG4105XTG Pfam:DUF156 S101392_02718 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein S101392_02719 ENOG41090E6 transcriptional regulator MERR family S101392_02722 ENOG4105C37 (CBS) domain S101392_02725 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family S101392_02726 ENOG4105H3G oxidoreductase S101392_02727 ENOG4105PGM cation diffusion facilitator family transporter S101392_02728 ENOG41090U3 tautomerase S101392_02732 ENOG4105KMT branched-chain amino acid S101392_02733 ENOG4108UMN azlc family S101392_02734 ENOG4108ZRZ Transcriptional regulator (AsnC family) S101392_02735 ENOG41067XF inhibitor S101392_02738 ENOG41064BW Protein of unknown function (DUF2568) S101392_02740 ENOG41075D4 Aminoglycoside 6-adenylyltransferase S101392_02741 ENOG4105EA8 2-Nitropropane dioxygenase S101392_02742 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) S101392_02745 ENOG4108MEK Metal-binding protein YodA S101392_02746 ENOG410904A RNA polymerase S101392_02747 ENOG4105CPC Aldo Keto reductase S101392_02749 ENOG4108KAM Transcriptional regulator S101392_02750 ENOG4105C7F AcnD-accessory protein PrpF S101392_02752 ENOG41083Q9 chitosanase S101392_02753 ENOG4105X5K response regulator receiver protein S101392_02754 ENOG4108VQT Alpha beta hydrolase fold protein S101392_02755 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein S101392_02756 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein S101392_02758 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase S101392_02760 ENOG4105PGS Spore coat protein S101392_02761 ENOG4105E2A Dehydrogenase S101392_02764 ENOG4105VUF Transcriptional regulator S101392_02766 ENOG4105DQ4 alcohol dehydrogenase S101392_02767 ENOG4108Z0Z intracellular protease Pfpi family S101392_02768 ENOG4108HKT sucrose-6-phosphate hydrolase S101392_02769 ENOG4105F3R pts system mannose fructose sorbose family iid S101392_02770 ENOG4105ETZ PTS System S101392_02771 ENOG4108IQ3 PTS system S101392_02772 ENOG4105YHU PTS system S101392_02773 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family S101392_02774 ENOG4105C85 amino acid S101392_02775 ENOG4105N14 lysine exporter protein LysE YggA S101392_02776 ENOG4108NGU Transcriptional regulator S101392_02777 ENOG4105JVQ RNA Polymerase S101392_02778 ENOG4108P49 AntiSigma factor S101392_02779 ENOG4105EXC Acyl-transferase S101392_02780 ENOG4105WDR S101392_02781 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S101392_02782 ENOG41082JN Transcriptional regulator S101392_02786 ENOG4105TMB Formate nitrite transporter S101392_02788 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) S101392_02789 ENOG4108JB9 formate dehydrogenase S101392_02792 ENOG4105C28 cystathionine S101392_02795 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) S101392_02798 ENOG4107XRG penicillin-binding protein S101392_02799 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) S101392_02800 ENOG4105DBI uridine monophosphokinase S101392_02801 ENOG4105CFP Peptidase U32 S101392_02802 ENOG4105XYU peptidase (U32 family) S101392_02803 ENOG4108VQJ O-methyltransferase S101392_02804 ENOG4105HHA aminodeoxychorismate lyase S101392_02805 ENOG4105VPH UPF0473 protein S101392_02806 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) S101392_02807 ENOG4105VBH UPF0297 protein S101392_02808 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) S101392_02809 ENOG4105C02 permease S101392_02810 ENOG4105CDA abc transporter atp-binding protein S101392_02811 ENOG4105CT1 (ABC) transporter S101392_02812 ENOG4105EAD ABC transporter S101392_02813 ENOG4105DRP amino acid AbC transporter S101392_02815 ENOG41060CR S101392_02817 ENOG4105C7H Helicase, RecD TraA family S101392_02819 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) S101392_02820 ENOG4105C3J Cysteine desulfurase S101392_02822 ENOG4105D1H recombination factor protein RarA S101392_02823 ENOG4105CUZ uba thif-type nad fad binding protein S101392_02824 ENOG4105C9M aspartyl-trna synthetase S101392_02825 ENOG4105CUT histidyl-tRNA synthetase S101392_02827 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101392_02829 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) S101392_02830 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) S101392_02831 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) S101392_02832 ENOG41067VP Protein of unknown function (DUF1049) S101392_02833 ENOG4105NCW Trka-c domain protein S101392_02834 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) S101392_02836 ENOG4105CKP Polysaccharide Biosynthesis Protein S101392_02837 ENOG4108QG2 Membrane S101392_02838 ENOG4105NAP S101392_02839 ENOG4105VIE preprotein translocase, subunit YajC S101392_02840 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) S101392_02841 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) S101392_02842 ENOG41061AI Protein of unknown function (DUF2905) S101392_02843 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) S101392_02844 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) S101392_02846 ENOG4105IE8 Alpha-ketoglutarate permease S101392_02847 ENOG4105CK5 oxidoreductase S101392_02851 ENOG4105BZG amino acid carrier protein S101392_02852 ENOG4105CDY transcriptional regulatory protein S101392_02854 ENOG4106678 morphogenetic protein associated with SpoVID S101392_02855 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) S101392_02856 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase S101392_02857 ENOG4108IYU L-aspartate oxidase S101392_02860 ENOG4105CQC Prephenate dehydratase S101392_02861 ENOG41090I5 UPF0735 ACT domain-containing protein S101392_02862 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control S101392_02864 ENOG4105K46 50S ribosomal protein l27 S101392_02865 ENOG4105X36 (ribosomal) protein S101392_02866 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) S101392_02869 ENOG4107QMS site-determining protein S101392_02870 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) S101392_02871 ENOG4105YHC Rod shape-determining protein MreD S101392_02872 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) S101392_02873 ENOG4105DFF Rod shape-determining protein mreb S101392_02874 ENOG4105W5Q DNA repair protein (RadC S101392_02875 ENOG4108Z03 MAF-like protein S101392_02877 ENOG4106A3R peptidase S101392_02878 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase S101392_02879 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) S101392_02881 ENOG4106AR7 Spore coat protein S101392_02882 ENOG41068KH stage VI sporulation protein D S101392_02883 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase S101392_02884 ENOG4105D52 delta-aminolevulinic acid dehydratase S101392_02886 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) S101392_02888 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) S101392_02890 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) S101392_02891 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) S101392_02892 ENOG4108IUQ atp-dependent protease S101392_02893 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) S101392_02894 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation S101392_02896 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S101392_02897 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S101392_02898 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S101392_02899 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) S101392_02900 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase S101392_02901 ENOG4108ZP8 Acetolactate synthase small subunit S101392_02902 ENOG4105C7K acetolactate synthase S101392_02904 ENOG4105I4A GCN5-related N-acetyltransferase S101392_02905 ENOG4107KM7 Heat induced stress protein YflT S101392_02907 ENOG4105M59 Phosphodiesterase, mj0936 family S101392_02908 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) S101392_02909 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) S101392_02910 ENOG4108XJQ germination protein S101392_02911 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) S101392_02912 ENOG41067TZ transcriptional regulator, MarR family S101392_02913 ENOG4105PFC Transcriptional regulator S101392_02915 ENOG4105E33 succinate dehydrogenase S101392_02917 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit S101392_02919 ENOG4105CFH Aspartokinase S101392_02920 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) S101392_02921 ENOG4105K63 Thioredoxin S101392_02922 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) S101392_02923 ENOG4105C10 Electron transfer flavoprotein S101392_02924 ENOG4105BZJ Electron transfer flavoprotein S101392_02925 ENOG41060WC Enoyl-CoA hydratase S101392_02926 ENOG4107Z3H Transcriptional regulator, TetR family S101392_02927 ENOG4105CEY Amp-dependent synthetase and ligase S101392_02929 ENOG4105C98 muts2 protein S101392_02930 ENOG4105DCG PHP domain protein S101392_02933 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S101392_02934 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) S101392_02935 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) S101392_02936 ENOG4108RWN rrna methyltransferase S101392_02937 ENOG41067MF small acid-soluble spore protein S101392_02939 ENOG4105CQB FAD linked oxidase domain protein S101392_02940 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S101392_02943 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) S101392_02944 ENOG4105DRS transport system, permease S101392_02947 ENOG4108MDK Dehydrogenase S101392_02949 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase S101392_02950 ENOG4105EF1 ribulokinase S101392_02952 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase S101392_02953 ENOG4105CN9 Peptidase m42 family protein S101392_02955 ENOG410696E Membrane S101392_02956 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) S101392_02957 ENOG4105VJV 50s ribosomal protein L35 S101392_02958 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) S101392_02960 ENOG41067MG lrgb family S101392_02962 ENOG4105DY9 regulatoR S101392_02963 ENOG4108HRK Histidine kinase S101392_02964 ENOG4105U0R haloacid dehalogenase-like hydrolase S101392_02965 ENOG4105C22 threonyL-tRNA synthetase S101392_02966 ENOG4108TDW sporulation protein YtxC S101392_02970 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) S101392_02971 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) S101392_02972 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S101392_02973 ENOG4105KVH Transcriptional regulator S101392_02974 ENOG4105F27 Major Facilitator S101392_02975 ENOG4105CV8 reductase S101392_02976 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) S101392_02978 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) S101392_02979 ENOG4105C2M dna polymerase I S101392_02980 ENOG4105BZU Histidine kinase S101392_02981 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101392_02982 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) S101392_02983 ENOG4108HMX isocitrate dehydrogenase (NADP) S101392_02984 ENOG4105BZN citrate synthase S101392_02986 ENOG4108REF Sporulation integral membrane protein ytvi S101392_02987 ENOG4105FS0 cytoplasmic membrane protein S101392_02988 ENOG4105CA9 Pyruvate kinase S101392_02989 ENOG4105CTQ phosphohexokinase S101392_02991 ENOG4108IEY Carboxyl transferase domain S101392_02992 ENOG4105C6K Malic enzyme S101392_02993 ENOG4105C0B DNA polymerase III (alpha subunit) S101392_02994 ENOG4105VV2 S101392_02996 ENOG4106EVM S101392_02997 ENOG4105SFS phosphoesterase RecJ domain protein S101392_03000 ENOG410635A Membrane S101392_03001 ENOG4105CH2 amidohydrolase S101392_03005 ENOG4105DEN Luciferase family S101392_03006 ENOG4105CDA abc transporter atp-binding protein S101392_03011 ENOG4108XSB acetyltransferase, (GNAT) family S101392_03012 ENOG4108KSA LysR family transcriptional regulator S101392_03013 ENOG4105E8R UPF0173 metal-dependent hydrolase S101392_03016 ENOG4105CH7 arginosuccinase S101392_03017 ENOG4105CDH Citrulline--aspartate ligase S101392_03018 ENOG4105EPU Molybdenum cofactor synthesis domain protein S101392_03019 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) S101392_03021 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) S101392_03022 ENOG4105KBJ sporulation protein ytfj S101392_03024 ENOG4105VK3 rdd domain containing protein S101392_03025 ENOG4105D07 Signal peptide peptidase, SppA S101392_03026 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) S101392_03027 ENOG4105EFZ amidohydrolase S101392_03028 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) S101392_03035 ENOG4105U5Y Transcriptional regulator S101392_03037 ENOG4105BZU Histidine kinase S101392_03038 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) S101392_03040 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S101392_03042 ENOG4105F1V Acetoin utilization protein S101392_03043 ENOG4105W87 Cbs domain S101392_03044 ENOG4105DGU Histone deacetylase S101392_03045 ENOG4105ER2 Ompa motb domain protein S101392_03046 ENOG4107R0U MotA TolQ exbB proton channel S101392_03047 ENOG4105ETE Transcriptional regulator (LacI family S101392_03048 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase S101392_03052 ENOG4105DFU Cell wall formation (By similarity) S101392_03054 ENOG4108VDD TRNA binding domain protein S101392_03057 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ S101392_03060 ENOG4105C6K Malic enzyme S101392_03061 ENOG4105C8F Beta-lactamase domain protein S101392_03062 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) S101392_03064 ENOG4108V15 phosphotransferase enzyme family S101392_03065 ENOG4108IUM Glycogen debranching enzyme S101392_03068 ENOG4107F58 2'-5' rna ligase S101392_03069 ENOG4105C6T cysteine synthase S101392_03070 ENOG4107QSE Dipeptidase S101392_03071 ENOG4105C7N Xanthine uracil vitamin C permease S101392_03074 ENOG4105YW5 deoR family transcriptional regulator S101392_03077 ENOG4105CBX hi0933 family S101392_03078 ENOG4105C94 Transporter S101392_03080 ENOG4105MU9 integral membrane protein S101392_03081 ENOG4105DDC Oxidoreductase domain protein S101392_03083 ENOG4105F5H Glycosyl Hydrolase Family 88 S101392_03085 ENOG41075H3 AraC family transcriptional regulator S101392_03087 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component S101392_03089 ENOG4106A3M Cytochrome p-450 S101392_03090 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) S101392_03092 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S101392_03093 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S101392_03095 ENOG4105NTD Inherit from COG: Hydrolase S101392_03098 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component S101392_03099 ENOG4105I1K ABC transporter S101392_03101 ENOG41085GJ domain protein S101392_03102 ENOG4105C8T Leucyl-tRNA synthetase S101392_03104 ENOG4105BZU Histidine kinase S101392_03105 ENOG410605W Major Facilitator S101392_03106 ENOG4106UBQ S101392_03108 ENOG4105C19 ABC transporter S101392_03109 ENOG4105EWM Histidine kinase S101392_03111 ENOG4107R34 abc transporter permease protein S101392_03112 ENOG4105C19 ABC transporter S101392_03115 ENOG4105DVE abc transporter atp-binding protein S101392_03116 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family S101392_03119 ENOG4105N5T Radical SAM Protein S101392_03122 ENOG4105E8V Alpha Beta Hydrolase Fold protein S101392_03123 ENOG4108Z0R Transferase S101392_03124 ENOG4105C85 amino acid S101392_03125 ENOG4105CAQ asparagine synthetase S101392_03126 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP S101392_03127 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase S101392_03130 ENOG4105D2X ABC transporter substrate-binding protein S101392_03132 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component S101392_03135 ENOG4108RMU ferritin dps family protein S101392_03138 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) S101392_03139 ENOG4108V2W Carbonate dehydratase S101392_03144 ENOG4105CC5 ABC transporter S101392_03145 ENOG4105CC5 ABC transporter S101392_03146 ENOG4105DIK (ABC) transporter S101392_03147 ENOG4105DSE periplasmic solute binding protein S101392_03148 ENOG4105DTQ mandelate racemase muconate lactonizing S101392_03149 ENOG4105CEY Amp-dependent synthetase and ligase S101392_03150 ENOG4108IPT Naphthoate synthase S101392_03151 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) S101392_03152 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) S101392_03153 ENOG4105E4F Isochorismate synthase S101392_03157 ENOG4108IAJ Nad-dependent epimerase dehydratase S101392_03158 ENOG4107SBE Glycosyl transferase (Group 1 S101392_03161 ENOG4107SBE Glycosyl transferase (Group 1 S101392_03162 ENOG4108KS4 Spore coat protein S101392_03165 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) S101392_03167 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) S101392_03193 ENOG4105N67 Proton-coupled thiamine transporter YuaJ S101392_03194 ENOG4105VRR gCN5-related N-acetyltransferase S101392_03195 ENOG4105DZ6 Band 7 protein S101392_03197 ENOG4106DF1 S101392_03198 ENOG4108VNY MOSC domain protein S101392_03199 ENOG4108JB8 alcohol dehydrogenase S101392_03200 ENOG4105C26 Dehydrogenase S101392_03201 ENOG4105TRT Transcriptional regulator S101392_03204 ENOG4105CZN Potassium uptake protein S101392_03205 ENOG4107I77 yiaA/B two helix domain S101392_03206 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S101392_03210 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) S101392_03212 ENOG4105EE0 oxidoreductase S101392_03213 ENOG4105DKG l-rhamnose isomerase S101392_03214 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) S101392_03215 ENOG4105DET Rhamnulokinase S101392_03216 ENOG4105E98 transcriptional regulator DeoR family S101392_03218 ENOG4105C8Q Methyl-accepting chemotaxis S101392_03219 ENOG4105C8Q Methyl-accepting chemotaxis S101392_03220 ENOG4105C8Q Methyl-accepting chemotaxis S101392_03221 ENOG4105C8Q Methyl-accepting chemotaxis S101392_03224 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme S101392_03226 ENOG4105C37 (CBS) domain S101392_03229 ENOG4107PBV potassium channel S101392_03230 ENOG4107PBV potassium channel S101392_03233 ENOG4107QYV phosphohexose isomerase S101392_03235 ENOG4107QW4 alcohol dehydrogenase S101392_03236 ENOG4105WG9 Conserved Protein S101392_03238 ENOG4105CHM Aminotransferase S101392_03239 ENOG4108ZB6 transcriptional regulator AsnC family S101392_03240 ENOG4108MUZ hydrolase S101392_03242 ENOG4105C87 Aminotransferase class I and II S101392_03243 ENOG4108HGU Histidine kinase S101392_03244 ENOG4105Y38 Kinase-associated protein B S101392_03248 ENOG4105BZ4 penicillin-binding protein S101392_03249 ENOG4105KIR Thiol-disulfide oxidoreductase dcc S101392_03252 ENOG4108MRH transcriptional regulatory protein S101392_03253 ENOG4105DIH basic membrane S101392_03254 ENOG4108JQ9 ABC transporter S101392_03255 ENOG4105UIB (ABC) transporter S101392_03259 ENOG4105D65 subunit l S101392_03260 ENOG4105HC0 Na H antiporter S101392_03261 ENOG4108ZE9 Monovalent cation H antiporter subunit C S101392_03262 ENOG4108JPZ Monovalent cation H antiporter subunit D S101392_03263 ENOG4105SC1 monovalent cation H antiporter subunit E S101392_03265 ENOG4105KJM monovalent cation h antiporter subunit g S101392_03266 ENOG4105KA0 thioesterase Superfamily protein S101392_03268 ENOG4105BZU Histidine kinase S101392_03273 ENOG4105D58 Diguanylate phosphodiesterase S101392_03274 ENOG4105DAP Nicotinate phosphoribosyltransferase S101392_03279 ENOG4105C02 permease S101392_03283 ENOG410904N short-chain dehydrogenase reductase S101392_03290 ENOG4108K8K Transcriptional regulator S101392_03291 ENOG4105DCF alanine dehydrogenase S101392_03293 ENOG4105WQT MbtH domain protein S101392_03294 ENOG4105CEY Amp-dependent synthetase and ligase S101392_03295 ENOG4105WQI isochorismatase S101392_03296 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase S101392_03297 ENOG4105E4F Isochorismate synthase S101392_03298 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase S101392_03299 ENOG4105NIV Esterase S101392_03303 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) S101392_03305 ENOG41069ER domain protein S101392_03307 ENOG4105CEP NADH dehydrogenase S101392_03308 ENOG4105CAY ferredoxin--nadp reductase S101392_03312 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 S101392_03313 ENOG4108YX9 iron--sulfur cluster insertion protein erpA S101392_03316 ENOG4105ZKE UPF0349 protein S101392_03319 ENOG41083MR nifu domain-containing protein S101392_03320 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein S101392_03321 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) S101392_03322 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) S101392_03323 ENOG4105D6E homoserine dehydrogenase S101392_03325 ENOG4108W5N phosphatidylglycerophosphatase a S101392_03326 ENOG4105D4U had-superfamily hydrolase, subfamily iia S101392_03328 ENOG4105MMD transcriptional regulator S101392_03329 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) S101392_03330 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) S101392_03331 ENOG4105FAA peptidase M23 S101392_03332 ENOG4108YTE sporulation protein YunB S101392_03333 ENOG4105KZD Domain of unknown function (DUF1805) S101392_03334 ENOG4107R8B 5'-nucleotidase S101392_03336 ENOG4105I3N Conserved Protein S101392_03338 ENOG4105CD3 dihydroorotase S101392_03339 ENOG4105G9B Transcriptional regulator S101392_03342 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) S101392_03343 ENOG4105VT2 5-hydroxyisourate hydrolase S101392_03344 ENOG4107YV9 domain protein S101392_03345 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding S101392_03348 ENOG4105XRQ Xanthine dehydrogenase accessory factor S101392_03350 ENOG4105C5R Aminotransferase S101392_03352 ENOG4108K8S endonuclease I S101392_03353 ENOG4108IJ9 (ABC) transporter S101392_03354 ENOG4105FDP GntR family transcriptional regulator S101392_03355 ENOG4108KPW sugar kinase S101392_03356 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component S101392_03357 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component S101392_03358 ENOG4105XN3 extracellular solute-binding protein family 1 S101392_03359 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine S101392_03360 ENOG4105PKS Excinuclease abc c subunit domain protein S101392_03361 ENOG4107VFR oxidoreductase S101392_03364 ENOG4105DIW FeS assembly protein SUFB S101392_03365 ENOG4108UNV SUF system FeS assembly protein, NifU family S101392_03366 ENOG4105C9B Cysteine desulfurase S101392_03367 ENOG4105JRK feS assembly protein SufD S101392_03368 ENOG4105C3K feS assembly ATPase SufC S101392_03370 ENOG4105D01 (LipO)protein S101392_03371 ENOG4108UMI ABC transporter, permease S101392_03372 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) S101392_03377 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) S101392_03378 ENOG41080E8 Transcriptional regulator, Spx MgsR family S101392_03379 ENOG4105C1G acyl-Coa dehydrogenase S101392_03380 ENOG4105CHU acetyl-coa acetyltransferase S101392_03386 ENOG41067TZ transcriptional regulator, MarR family S101392_03387 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101392_03388 ENOG4105MDS 4-oxalocrotonate tautomerase S101392_03390 ENOG4105EGI Transcriptional regulator S101392_03392 ENOG4105E0A ABC, transporter S101392_03395 ENOG4105E1F short-chain dehydrogenase reductase S101392_03396 ENOG4105HUF DNA protection during starvation protein S101392_03397 ENOG4105C0H protease S101392_03399 ENOG4105F3H Histidine kinase S101392_03400 ENOG41067SE Tetr family transcriptional regulator S101392_03401 ENOG4105C9Q fumarate hydratase class II S101392_03406 ENOG4105WH1 Two component transcriptional regulator luxr family S101392_03407 ENOG4105ENE Histidine kinase S101392_03410 ENOG41087YS Phage shock protein A S101392_03413 ENOG4108WBT adenosyltransferase S101392_03414 ENOG4105E0A ABC, transporter S101392_03415 ENOG4105EHG Permease protein S101392_03416 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) S101392_03417 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S101392_03418 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein S101392_03420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101392_03422 ENOG4106DF4 Sigma-70, region 4 S101392_03424 ENOG4105F0F Oxalate decarboxylase S101392_03426 ENOG4107RBB ABC transporter, permease S101392_03427 ENOG4105C19 ABC transporter S101392_03428 ENOG4108WMK Efflux transporter RND family MFP subunit S101392_03429 ENOG4105E0A ABC, transporter S101392_03430 ENOG4105EHG Permease protein S101392_03431 ENOG4105DQ5 transport system permease protein S101392_03433 ENOG4105D5Q Arginine ornithine antiporter S101392_03435 ENOG4107K5X Membrane-bound metal-dependent hydrolase S101392_03436 ENOG4107QZ2 Sulfatase S101392_03437 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family S101392_03438 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein S101392_03439 ENOG4105E0C molybdate abc transporter S101392_03442 ENOG4105EEQ Na H antiporter S101392_03443 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) S101392_03444 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S101392_03445 ENOG4105EEM helicase S101392_03447 ENOG4105EN6 Membrane S101392_03449 ENOG4107ZQN disulfide bond S101392_03450 ENOG4105C59 p-type ATPase S101392_03451 ENOG4105C59 p-type ATPase S101392_03452 ENOG410681U heavy metal transport detoxification protein S101392_03453 ENOG4105VPX protein, conserved in bacteria S101392_03454 ENOG4105D9R oxidoreductase S101392_03455 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) S101392_03456 ENOG4105ME7 Membrane S101392_03457 ENOG4105RXJ S101392_03458 ENOG4105KPY Small multidrug resistance protein S101392_03459 ENOG4105KBX Transcriptional regulator, TetR family S101392_03460 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S101392_03461 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) S101392_03462 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) S101392_03464 ENOG4105XZU Preprotein translocase, subunit SecG S101392_03469 ENOG4105KVH Transcriptional regulator S101392_03470 ENOG4105C8Q Methyl-accepting chemotaxis S101392_03471 ENOG4105R40 Glycine betaine carnitine choline S101392_03472 ENOG4108HQR Glycine betaine S101392_03473 ENOG4105E90 ABC transporter S101392_03474 ENOG4108IJ8 ABC transporter S101392_03475 ENOG4107HG4 Transcriptional regulator S101392_03476 ENOG4105R40 Glycine betaine carnitine choline S101392_03477 ENOG4108HQR Glycine betaine S101392_03478 ENOG4105E90 ABC transporter S101392_03479 ENOG4108IJ8 ABC transporter S101392_03480 ENOG4107HG4 Transcriptional regulator S101392_03481 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein S101392_03482 ENOG4108QCI YvbH-like oligomerisation region S101392_03484 ENOG4105T65 Membrane-associated protein S101392_03485 ENOG4108W0I acetyltransferase S101392_03488 ENOG4105FJR Lmbe family S101392_03491 ENOG4105CHM Aminotransferase S101392_03492 ENOG4108IAJ Nad-dependent epimerase dehydratase S101392_03493 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S101392_03494 ENOG4107QQG Dehydrogenase S101392_03495 ENOG4105IIU Aminopeptidase S101392_03496 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) S101392_03497 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) S101392_03498 ENOG4105CP7 Triose-phosphate isomerase S101392_03499 ENOG4105BZA Phosphoglycerate kinase S101392_03500 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S101392_03503 ENOG4105CMD Transcriptional regulator, GntR family S101392_03504 ENOG4105DEN Luciferase family S101392_03505 ENOG4105GZI Transcriptional regulator S101392_03506 ENOG4107RT3 EamA-like transporter family S101392_03508 ENOG4105VRS hydrolase family 18 S101392_03509 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) S101392_03510 ENOG4107QR9 Iron-sulfur cluster binding protein S101392_03511 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S101392_03513 ENOG4105BZU Histidine kinase S101392_03514 ENOG4105KCT ABC transporter S101392_03515 ENOG4108M15 ABC transporter S101392_03516 ENOG4107R6F Alpha Beta Hydrolase Fold protein S101392_03517 ENOG4108MJI response regulator S101392_03520 ENOG4105EG2 ABC transporter, permease S101392_03522 ENOG4107FKK extracellular solute-binding protein family 1 S101392_03524 ENOG4105JXH GntR family transcriptional regulator S101392_03525 ENOG4105DAA L-lactate S101392_03526 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101392_03528 ENOG4108ZPC Polysaccharide pyruvyl transferase S101392_03529 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S101392_03530 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family S101392_03531 ENOG4105D3Q Sugar transferase S101392_03533 ENOG4105K64 Glycosyl transferase, family 2 S101392_03535 ENOG4107QRS glycosyltransferase group 2 family protein S101392_03536 ENOG41068W6 Capsular polysaccharide biosynthesis protein S101392_03537 ENOG4108KMV Glycosyl transferase (Group 1 S101392_03538 ENOG4105K64 Glycosyl transferase, family 2 S101392_03539 ENOG4108PQP glycosyl transferase group 1 S101392_03541 ENOG4108QV3 biosynthesis protein S101392_03542 ENOG4105HTX biosynthesis protein S101392_03544 ENOG4105EBR Carboxylesterase S101392_03546 ENOG4105PY6 Phenolic acid decarboxylase S101392_03547 ENOG4105NI3 Protein of unknown function (DUF3237) S101392_03549 ENOG4105FQP Beta-lactamase S101392_03550 ENOG4105EDQ levansucrase EC 2.4.1.10 S101392_03551 ENOG4108HKT sucrose-6-phosphate hydrolase S101392_03552 ENOG4107QTZ amino acid S101392_03557 ENOG4105DNP FAD linked oxidase domain protein S101392_03558 ENOG4105IRW patatin-like phospholipase family protein S101392_03560 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S101392_03561 ENOG4107URF beta-phospho-glucomutase S101392_03562 ENOG4105CG3 alpha amylase, catalytic region S101392_03565 ENOG4105EG2 ABC transporter, permease S101392_03566 ENOG4105D56 permease protein S101392_03567 ENOG4107FKK extracellular solute-binding protein family 1 S101392_03568 ENOG4108IUK alpha amylase, catalytic S101392_03569 ENOG4105FKQ transcriptional regulator S101392_03570 ENOG4108URH decarboxylase S101392_03571 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain S101392_03572 ENOG4105CHH sulfate transporter S101392_03573 ENOG4108V2W Carbonate dehydratase S101392_03574 ENOG4105C5I Dehydrogenase S101392_03576 ENOG4105C19 ABC transporter S101392_03577 ENOG4105EWM Histidine kinase S101392_03579 ENOG4107A6P S101392_03580 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase S101392_03581 ENOG4105KRI phosphocarrier protein (HPr S101392_03582 ENOG4105CIE May be required for sporulation (By similarity) S101392_03583 ENOG4105CHW UPF0052 protein S101392_03584 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) S101392_03585 ENOG4108Z4K mutator MutT protein S101392_03586 ENOG4105C3M thioredoxin reductase S101392_03589 ENOG4105BZ1 (ABC) transporter S101392_03591 ENOG4106FGC S101392_03593 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase S101392_03594 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) S101392_03595 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase S101392_03596 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) S101392_03597 ENOG4105ECC imidazole-glycerol-phosphate dehydratase S101392_03598 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) S101392_03599 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) S101392_03600 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) S101392_03602 ENOG4108E16 pectate lyase S101392_03603 ENOG4108S4C acetyltransferase S101392_03604 ENOG4107XGZ Hydrolase S101392_03605 ENOG4105HKU nucleoside recognition domain-containing protein S101392_03606 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) S101392_03607 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) S101392_03608 ENOG4105CE4 GlcNAc 6-P deacetylase S101392_03609 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) S101392_03610 ENOG4105FDP GntR family transcriptional regulator S101392_03611 ENOG41088CQ domain protein S101392_03612 ENOG41086DT Membrane protein of unknown function S101392_03613 ENOG41067S9 phage shock protein C, PspC S101392_03614 ENOG4108PY7 S101392_03617 ENOG4105I03 Flagellin S101392_03618 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) S101392_03619 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) S101392_03622 ENOG4105MKU Transcriptional regulator S101392_03626 ENOG4105CN1 protease S101392_03627 ENOG4105CRP Part of the ABC transporter FtsEX involved in S101392_03628 ENOG4105CAK Cell division ATP-binding protein ftsE S101392_03631 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) S101392_03633 ENOG4105MS2 ribosomal subunit Interface protein S101392_03636 ENOG4105MQ3 flagellar protein FliS S101392_03637 ENOG4107RT6 flagellar hook-associated S101392_03638 ENOG41083S7 flagellar protein FlaG S101392_03639 ENOG4105I03 Flagellin S101392_03640 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) S101392_03641 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) S101392_03642 ENOG4105MKD S101392_03643 ENOG4105DTJ flagellar hook-associated protein S101392_03644 ENOG4105E1Q flagellar hook-associated protein S101392_03647 ENOG4105RU3 S101392_03648 ENOG41081UC Inherit from COG: Competence protein S101392_03652 ENOG4105WH1 Two component transcriptional regulator luxr family S101392_03653 ENOG4105BZU Histidine kinase S101392_03654 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein S101392_03655 ENOG4108KGH TRANSCRIPTIONal S101392_03656 ENOG4105ESV Glycosyl transferase, family 4 S101392_03657 ENOG4107EF8 Glycosyl transferase (Group 1 S101392_03660 ENOG4105QZI O-Antigen Polymerase S101392_03661 ENOG4105C6Y Udp-glucose 6-dehydrogenase S101392_03662 ENOG4107RA4 Glycosyl transferase (Group 1 S101392_03663 ENOG4105PSV Polysaccharide Biosynthesis Protein S101392_03664 ENOG4105D3Q Sugar transferase S101392_03666 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101392_03667 ENOG4105JFG SpoIID LytB domain protein S101392_03670 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase S101392_03674 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S101392_03675 ENOG4105EY8 ABC transporter S101392_03677 ENOG4107VDP teichoic acid biosynthesis S101392_03678 ENOG41088M2 Glycosyl transferase family 2 S101392_03688 ENOG4105DG6 mannose-6-phosphate isomerase S101392_03691 ENOG4108NHD germination protein S101392_03692 ENOG4105C54 Major Facilitator superfamily S101392_03693 ENOG4108KGH TRANSCRIPTIONal S101392_03694 ENOG4105J7I hydrolase S101392_03695 ENOG4105K4H Nlp p60 protein S101392_03697 ENOG4105PNM synthesis protein S101392_03699 ENOG4105N98 Capsule biosynthesis protein capB S101392_03700 ENOG4105ETE Transcriptional regulator (LacI family S101392_03701 ENOG4108RVA ribokinase S101392_03702 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) S101392_03703 ENOG4105C2J ABC transporter S101392_03704 ENOG4105CNN ABC, transporter S101392_03705 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator S101392_03708 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein S101392_03709 ENOG4107FQX Alpha-acetolactate decarboxylase S101392_03711 ENOG4107RSM transcriptional regulator S101392_03714 ENOG4106UIA S101392_03717 ENOG4107XC4 flavin reductase domain protein, FMN-binding S101392_03719 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S101392_03721 ENOG4105CAH Chromate S101392_03722 ENOG4105FGV Chromate S101392_03724 ENOG4108WS4 fmn reductase S101392_03725 ENOG4107V2S Transcriptional regulator S101392_03726 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) S101392_03731 ENOG4108XI2 Domain of unknown function (DUF1963) S101392_03732 ENOG4105C6Y Udp-glucose 6-dehydrogenase S101392_03733 ENOG4108RB3 Capsular polysaccharide biosynthesis protein S101392_03734 ENOG4107YJ4 chain length determinant protein S101392_03735 ENOG4105HTX biosynthesis protein S101392_03737 ENOG4105KBK Zinc finger, swim domain protein S101392_03738 ENOG4105C0D helicase S101392_03739 ENOG410667J hydrolase S101392_03740 ENOG4105E98 transcriptional regulator DeoR family S101392_03741 ENOG4105Z8H single-stranded DNA-binding protein S101392_03746 ENOG4108VAC response regulator S101392_03748 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) S101392_03749 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) S101392_03751 ENOG4105CGA flagellar basal-body rod protein FlgG S101392_03753 ENOG4105DFF Rod shape-determining protein mreb S101392_03754 ENOG4105MT0 Sporulation transcriptional regulator spoiiid S101392_03755 ENOG4107MII Sugar-specific transcriptional regulator TrmB S101392_03756 ENOG4105CZM Major Facilitator S101392_03757 ENOG4108M26 parallel beta-helix repeat protein S101392_03758 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease S101392_03759 ENOG41080V3 Major Facilitator superfamily S101392_03760 ENOG4105D3W isochorismatase S101392_03761 ENOG4107P26 S101392_03762 ENOG4105BZU Histidine kinase S101392_03764 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase S101392_03766 ENOG4105FRN stage II sporulation protein S101392_03767 ENOG4107TCE N-acetyltransferase S101392_03770 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S101392_03771 ENOG4107TXC Transcriptional regulator S101392_03772 ENOG4106BRK S101392_03773 ENOG4108RYK Nad-dependent epimerase dehydratase S101392_03774 ENOG4108Z40 Transcriptional regulator S101392_03775 ENOG4105CQM Urea amidohydrolase subunit alpha S101392_03776 ENOG4105KI2 Urea amidohydrolase subunit beta S101392_03777 ENOG4108YZ9 Urea amidohydrolase subunit gamma S101392_03783 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) S101392_03785 ENOG4108TF4 von Willebrand factor, type A S101392_03787 ENOG4105JFG SpoIID LytB domain protein S101392_03788 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S101392_03790 ENOG4106778 Protein of unknown function (DUF1146) S101392_03792 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) S101392_03793 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) S101392_03794 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) S101392_03795 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) S101392_03799 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) S101392_03801 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) S101392_03802 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) S101392_03803 ENOG4108UIC UPF0340 protein S101392_03804 ENOG4108YZG isomerase S101392_03805 ENOG4107WAU Protein tyrosine phosphatase S101392_03806 ENOG410815N Probably functions as a manganese efflux pump (By similarity) S101392_03807 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S101392_03809 ENOG4108ZXQ stage ii sporulation protein r S101392_03812 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) S101392_03813 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) S101392_03814 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase S101392_03816 ENOG4107TT2 Auxin Efflux Carrier S101392_03817 ENOG4105C6K Malic enzyme S101392_03818 ENOG4107104 thymidine kinase S101392_03819 ENOG41082DI 50s ribosomal protein l31 S101392_03820 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) S101392_03821 ENOG4105CBT Fructose-1,6-bisphosphatase S101392_03822 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S101392_03823 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway S101392_03824 ENOG4105D2N Aldolase S101392_03825 ENOG410812K response regulator receiver protein S101392_03827 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) S101392_03829 ENOG4105C1G acyl-Coa dehydrogenase S101392_03830 ENOG4105DF6 Fe-S oxidoreductase S101392_03832 ENOG4105E5J UV damage endonuclease S101392_03834 ENOG4105NAE bifunctional deaminase-reductase domain protein S101392_03835 ENOG4105BZ1 (ABC) transporter S101392_03836 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S101392_03838 ENOG4105R3A Nitrate reductase S101392_03839 ENOG4108IUE nitrate reductase beta subunit S101392_03843 ENOG4107V6Q Cyclic nucleotide-binding domain S101392_03845 ENOG4105C75 arginyL-tRNA synthetase S101392_03846 ENOG410684U Domain of unknown function (DUF1934) S101392_03848 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E S101392_03857 ENOG4107JM4 Tetratricopeptide repeat S101392_03863 ENOG4108RDQ ABC transporter S101392_03865 ENOG4105CYW agmatinase S101392_03866 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) S101392_03867 ENOG4105BZ4 penicillin-binding protein S101392_03868 ENOG4108XFG YwhD family S101392_03869 ENOG4108Z4T Peptidase M50 S101392_03870 ENOG41069HH 4-oxalocrotonate tautomerase S101392_03871 ENOG41067TZ transcriptional regulator, MarR family S101392_03872 ENOG4105C22 threonyL-tRNA synthetase S101392_03874 ENOG4105C57 major facilitator superfamily S101392_03875 ENOG41062ES Transcriptional regulator S101392_03877 ENOG4105DCI Phosphohydrolase S101392_03879 ENOG4108VCI transcription factor, rsfa family S101392_03880 ENOG4108RNG Permease of the drug metabolite transporter S101392_03881 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) S101392_03882 ENOG4105DUM transcriptional regulator, lysR family S101392_03883 ENOG4108IJ2 phosphate acetyltransferase S101392_03886 ENOG4105CHM Aminotransferase S101392_03888 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase S101392_03889 ENOG4105CHR reductase S101392_03890 ENOG4106CHD Bacilysin biosynthesis protein bacB S101392_03891 ENOG41061WN bacilysin biosynthesis protein S101392_03892 ENOG4105FCW Major Facilitator superfamily S101392_03895 ENOG4105C26 Dehydrogenase S101392_03896 ENOG4105D82 Glutamate dehydrogenase S101392_03898 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase S101392_03899 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase S101392_03900 ENOG4105C1B dTDP-glucose 4-6-dehydratase S101392_03901 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) S101392_03902 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG S101392_03903 ENOG4107TY6 Acylneuraminate cytidylyltransferase S101392_03905 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD S101392_03906 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S101392_03913 ENOG4105C26 Dehydrogenase S101392_03914 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) S101392_03915 ENOG4108RJ9 Glycosyl transferase, family 2 S101392_03919 ENOG4105DWF phosphomethylpyrimidine kinase S101392_03922 ENOG4105C5Y PTS System S101392_03923 ENOG4108QTI )-transporter S101392_03926 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin S101392_03927 ENOG4105DEN Luciferase family S101392_03928 ENOG4108DBC nitroreductase S101392_03931 ENOG41060D1 Quinol oxidase S101392_03932 ENOG4105CCU oxidase (Subunit III) S101392_03933 ENOG4105BZ9 Cytochrome C oxidase, subunit I S101392_03934 ENOG4105E2S oxidase) subunit II S101392_03935 ENOG4107BMA Transglycosylase associated protein S101392_03937 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) S101392_03938 ENOG4105WH5 Teichoic acid glycosylation protein S101392_03943 ENOG4107ZXU DSBA oxidoreductase S101392_03944 ENOG4105DBE peroxidase S101392_03945 ENOG410650H (LipO)protein S101392_03946 ENOG4107SJW iron permease, FTR1 S101392_03947 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) S101392_03949 ENOG4105CMU LysR family (Transcriptional regulator S101392_03950 ENOG4105VAW lrga family S101392_03951 ENOG41067MG lrgb family S101392_03952 ENOG4105D8G Major Facilitator superfamily S101392_03954 ENOG4105DR4 Methyltransferase S101392_03956 ENOG4108YV3 Protein of unknown function (DUF2711) S101392_03957 ENOG4105CK1 PTS System S101392_03958 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin S101392_03961 ENOG4105X1N Glycosyl transferase family 8 S101392_03963 ENOG4105GVJ transcriptional regulator S101392_03964 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S101392_03965 ENOG4105IIU Aminopeptidase S101392_03970 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase S101392_03972 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) S101392_03973 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein S101392_03975 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD S101392_03976 ENOG4108VHC Short-chain dehydrogenase reductase Sdr S101392_03977 ENOG4105CM2 brancheD-chain amino acid aminotransferase S101392_03978 ENOG4105F8D glycoside hydrolase family 4 S101392_03979 ENOG4105VCP PTS System S101392_03980 ENOG4105CK1 PTS System S101392_03981 ENOG4105VZJ PTS System S101392_03982 ENOG4105EMD TRANSCRIPTIONal S101392_03984 ENOG4108VX5 3-methyladenine DNA glycosylase S101392_03985 ENOG4105CH6 catalase S101392_03988 ENOG4105DA5 (ABC) transporter S101392_03989 ENOG41069JR S101392_03993 ENOG4105ETS cytosine purines uracil thiamine allantoin S101392_03994 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) S101392_03995 ENOG4108JJ8 (ABC) transporter S101392_03996 ENOG4108JJ9 ABC, transporter S101392_03997 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii S101392_03998 ENOG4105C4M (Ubiquinol oxidase) subunit I S101392_03999 ENOG4105D2K citrate carrier protein S101392_04002 ENOG4107BJW polysaccharide deacetylase S101392_04006 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) S101392_04008 ENOG4105CMR udp-glucose 4-epimerase S101392_04009 ENOG4105KIS phospholipid-binding protein S101392_04010 ENOG4108WAV Transcriptional regulator S101392_04012 ENOG4105BZU Histidine kinase S101392_04013 ENOG4105WH1 Two component transcriptional regulator luxr family S101392_04014 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S101392_04020 ENOG4105DTD Dehydrogenase S101392_04021 ENOG4108IIH CoA-transferase subunit B S101392_04022 ENOG4105D6N CoA-transferase, subunit a S101392_04023 ENOG4105CY2 Citrate transporter S101392_04024 ENOG4105DHI Methyltransferase S101392_04028 ENOG4105CH6 catalase S101392_04029 ENOG4105D4T Citrate transporter S101392_04030 ENOG4108RZ2 Glycoside hydrolase family 16 S101392_04031 ENOG4105CID antiterminator S101392_04033 ENOG4105DEU major facilitator superfamily S101392_04034 ENOG4105C1J atp-dependent rna helicase S101392_04035 ENOG4107TDE lipolytic protein G-D-S-L family S101392_04041 ENOG4107EXU Short-chain dehydrogenase reductase Sdr S101392_04043 ENOG4107YZX Universal stress protein S101392_04044 ENOG4105CS2 ec 3.2.1.21 S101392_04045 ENOG4105C5Y PTS System S101392_04048 ENOG4107EV6 Inherit from COG: YD repeat protein S101392_04051 ENOG4106Z5D Glycoside Hydrolase Family 43 S101392_04053 ENOG4105C84 Histidine ammonia-lyase S101392_04054 ENOG4105CGP Urocanate hydratase S101392_04055 ENOG4105CI2 imidazolone-5-propionate hydrolase S101392_04056 ENOG4107W25 arginase agmatinase formiminoglutamase S101392_04058 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) S101392_04059 ENOG4105D9N nucleoside S101392_04061 ENOG4107RHR regulatoR S101392_04062 ENOG4108TM9 integral membrane protein S101392_04063 ENOG4105ENY Ethanolamine utilization protein eutH S101392_04064 ENOG4108PGP mmge prpd family protein S101392_04065 ENOG4105CH2 amidohydrolase S101392_04067 ENOG4108HW4 amino acid AbC transporter S101392_04068 ENOG4105EAB amino acid AbC transporter S101392_04069 ENOG4108XSB acetyltransferase, (GNAT) family S101392_04070 ENOG4105CPU Monooxygenase S101392_04071 ENOG4107QHE Choloylglycine hydrolase S101392_04072 ENOG410667J hydrolase S101392_04078 ENOG4108V5C ABC transporter S101392_04084 ENOG4105D2N Aldolase S101392_04085 ENOG4107TRN Xylose isomerase domain protein TIM barrel S101392_04086 ENOG4105F0H myo-inositol catabolism protein S101392_04087 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S101392_04089 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) S101392_04090 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) S101392_04091 ENOG4105D7K pfkb domain protein S101392_04093 ENOG4105C26 Dehydrogenase S101392_04095 ENOG4105CPC Aldo Keto reductase S101392_04098 ENOG4107QNK )-transporter S101392_04099 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) S101392_04101 ENOG41061TZ Short-chain dehydrogenase reductase Sdr S101392_04102 ENOG4105ST3 Transcriptional regulator S101392_04103 ENOG4105C26 Dehydrogenase S101392_04105 ENOG41085PJ rdd domain containing protein S101392_04106 ENOG4108ITS PQQ enzyme repeat S101392_04108 ENOG41085PJ rdd domain containing protein S101392_04111 ENOG4105J7D transcriptional regulator S101392_04112 ENOG4107JEE Short-chain dehydrogenase reductase Sdr S101392_04113 ENOG41061AU MarR family Transcriptional regulator S101392_04115 ENOG41067MG lrgb family S101392_04117 ENOG4105BZW Glycerate kinase S101392_04118 ENOG4105G3Z GntR family transcriptional regulator S101392_04119 ENOG4105CMG Carbohydrate kinase S101392_04120 ENOG4105C6Z Gluconate S101392_04121 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) S101392_04122 ENOG4105D3R alkyl hydroperoxide reductase S101392_04123 ENOG4108JU3 Alkyl hydroperoxide reductase S101392_04124 ENOG4105CS2 ec 3.2.1.21 S101392_04126 ENOG4108S3Y transcriptional regulator S101392_04127 ENOG4106KKU S101392_04128 ENOG4108Z15 abc transporter atp-binding protein S101392_04129 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 S101392_04131 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) S101392_04134 ENOG4105E2A Dehydrogenase S101392_04138 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) S101392_04139 ENOG4105WQG acetyltransferase S101392_04140 ENOG410780I phosphoprotein phosphatase activity S101392_04142 ENOG41066UZ arginase EC 3.5.3.1 S101392_04143 ENOG4108IQI permease S101392_04144 ENOG4105C8Y Acetylornithine aminotransferase S101392_04145 ENOG4108JUB Transcriptional regulator S101392_04146 ENOG4105BZU Histidine kinase S101392_04150 ENOG4105C0H protease S101392_04151 ENOG4105Q2H domain protein S101392_04154 ENOG4105BZU Histidine kinase S101392_04155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101392_04160 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis S101392_04161 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase S101392_04162 ENOG4105CDU Replicative dna helicase S101392_04166 ENOG4105DJ2 Major Facilitator Superfamily S101392_04167 ENOG4105EDW glycosyl transferase, family 39 S101392_04168 ENOG4105K9Q Binds to the 23S rRNA (By similarity) S101392_04169 ENOG4105BZR domain protein S101392_04170 ENOG4108XMW Membrane S101392_04173 ENOG4105KVH Transcriptional regulator S101392_04174 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase S101392_04178 ENOG41090E6 transcriptional regulator MERR family S101392_04180 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein S101392_04181 ENOG4105DDN Pentapeptide repeat-containing protein S101392_04182 ENOG4105D94 Major Facilitator Superfamily S101392_04183 ENOG4107RSM transcriptional regulator S101392_04184 ENOG41082BV acetyltransferase S101392_04185 ENOG41081I9 integral membrane protein S101392_04187 ENOG4108U05 Transcriptional regulator S101392_04188 ENOG41082BV acetyltransferase S101392_04190 ENOG4108U7W acetyltransferase S101392_04191 ENOG4105UNS Pfam:DUF419 S101392_04192 ENOG4105NAE bifunctional deaminase-reductase domain protein S101392_04194 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit S101392_04196 ENOG4105C7Z Conserved Protein S101392_04197 ENOG4107FCW Abortive infection protein S101392_04199 ENOG4108UW5 maltose o-acetyltransferase S101392_04200 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase S101392_04202 ENOG4105CGK Exodeoxyribonuclease III S101392_04203 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) S101392_04204 ENOG4108UUM single-stranded DNA-binding protein S101392_04205 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) S101392_04206 ENOG4105C3G gtp-binding protein S101392_04207 ENOG4108J2R molybdopterin oxidoreductase S101392_04208 ENOG4105VDK protein, conserved in bacteria S101392_04210 ENOG4108ZDA Sporulation protein YyaC S101392_04211 ENOG4105FA0 parb-like partition protein S101392_04212 ENOG4107QJE Chromosome Partitioning Protein S101392_04215 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) S101392_04216 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) S101392_04217 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) S101392_04220 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)