locus-tag class description HC658_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HC658_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HC658_00030 ENOG410848D S4 domain protein YaaA HC658_00060 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC658_00070 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC658_00140 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HC658_00160 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HC658_00170 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HC658_00180 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HC658_00200 ENOG4105ZMH deoxynucleoside kinase HC658_00220 ENOG4105VRS hydrolase family 18 HC658_00230 ENOG4105GTG Isochorismatase HC658_00240 ENOG4108Z6B deaminase HC658_00260 ENOG4105C6E dna polymerase iii HC658_00270 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HC658_00280 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HC658_00300 ENOG41067KS pro-sigma K processing HC658_00380 ENOG4105CDW Resistance protein HC658_00390 ENOG4105CXN decarboxylase HC658_00400 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HC658_00410 ENOG4105X0R protein from nitrogen regulatory protein P-II HC658_00420 ENOG4105XVJ Protein of unknown function (DUF327) HC658_00430 ENOG4105FA2 dna polymerase iii HC658_00440 ENOG4105MA4 psp1 domain protein HC658_00450 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) HC658_00460 ENOG41060K3 Methyltransferase HC658_00470 ENOG4105VC4 domain protein HC658_00480 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HC658_00490 ENOG4105KRN Transcriptional regulator, abrb family HC658_00500 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HC658_00510 ENOG4105F8V Hydrolase, tatD family HC658_00520 ENOG41069ER domain protein HC658_00540 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HC658_00550 ENOG4105XFA sporulation peptidase YabG HC658_00560 ENOG4105W42 Veg protein HC658_00570 ENOG4105XEW small acid-soluble spore protein HC658_00580 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HC658_00590 ENOG4105DFT pur operon repressor HC658_00600 ENOG4105KME endoribonuclease L-psp HC658_00610 ENOG4105K4W Could be involved in septation (By similarity) HC658_00620 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HC658_00630 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HC658_00640 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HC658_00650 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HC658_00670 ENOG4108JA2 transcriptioN-repair coupling factor HC658_00680 ENOG4108M14 stage v sporulation protein t HC658_00700 ENOG4108IY2 MazG family HC658_00710 ENOG41082I2 s4 domain protein HC658_00720 ENOG4105VYY sporulation protein yabp HC658_00750 ENOG41060GV RNA binding s1 domain protein HC658_00810 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HC658_00820 ENOG4108UGV hypoxanthine phosphoribosyltransferase HC658_00830 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HC658_00850 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HC658_00860 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HC658_00870 ENOG4105C6T cysteine synthase HC658_00880 ENOG4105CRQ synthase (Component I) HC658_00890 ENOG4105DDQ anthranilate synthase HC658_00900 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HC658_00910 ENOG4105EEI dihydropteroate synthase HC658_00920 ENOG4105KRF dihydroneopterin aldolase HC658_00930 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HC658_00950 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HC658_00960 ENOG4105CRK lysyL-tRNA synthetase HC658_01130 ENOG4108Z0C Uvrb UvrC protein HC658_01140 ENOG41066A3 ATP guanido phosphotransferase HC658_01160 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HC658_01170 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HC658_01180 ENOG4105CTP PilT protein domain protein HC658_01190 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HC658_01200 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HC658_01210 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HC658_01220 ENOG4105D7W serine acetyltransferase HC658_01230 ENOG4105C8N cysteinyl-tRNA synthetase HC658_01240 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HC658_01250 ENOG4105C2N RNA methyltransferase TrmH family group 3 HC658_01260 ENOG4105M0M Tetracycline resistance protein HC658_01300 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HC658_01330 ENOG4108VZM 50s ribosomal protein L10 HC658_01350 ENOG4107Y49 methyltransferase HC658_01360 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HC658_01370 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HC658_01380 ENOG4105XPM ribosomal protein HC658_01390 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HC658_01400 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HC658_01410 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HC658_01420 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HC658_01430 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HC658_01440 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HC658_01450 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HC658_01460 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HC658_01480 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HC658_01510 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HC658_01520 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HC658_01540 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HC658_01550 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HC658_01570 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HC658_01590 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HC658_01600 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HC658_01610 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HC658_01620 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HC658_01640 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HC658_01650 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HC658_01670 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HC658_01700 ENOG41067V7 50S ribosomal protein L36 HC658_01710 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HC658_01720 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HC658_01730 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HC658_01740 ENOG4108ZT0 50S ribosomal protein l17 HC658_01750 ENOG4108JJB ABC transporter HC658_01760 ENOG4108JJB ABC transporter HC658_01770 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HC658_01780 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HC658_01790 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HC658_01800 ENOG4108UJD 30S ribosomal protein S9 HC658_01810 ENOG4108I0C methyltransferase HC658_01840 ENOG4105D1F ATP-binding protein HC658_01870 ENOG4108NMV polysaccharide deacetylase HC658_02040 ENOG4105CHH sulfate transporter HC658_02060 ENOG4108SA1 esterase HC658_02100 ENOG410874W AraC family transcriptional regulator HC658_02110 ENOG4105EHZ conserved protein UCP016719 HC658_02120 ENOG4105D17 glycoside hydrolase, family 3 domain protein HC658_02160 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HC658_02180 ENOG4105EWC Purine nucleoside phosphorylase HC658_02240 ENOG4105EMN RNA polymerase sigma factor HC658_02260 ENOG4105C8B TIGR00159 family HC658_02270 ENOG4107U5W ybbr family HC658_02280 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HC658_02290 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HC658_02300 ENOG4105D03 DNA-3-methyladenine glycosylase II HC658_02320 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HC658_02330 ENOG4108TWJ NADH dehydrogenase subunit 5 HC658_02370 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HC658_02380 ENOG4105WAB arsR family transcriptional regulator HC658_02390 ENOG4108RWP Major Facilitator Superfamily protein HC658_02420 ENOG4107ZBH radical SAM domain protein HC658_02430 ENOG41066N6 Abortive infection protein HC658_02440 ENOG4108WUZ (ABC) transporter HC658_02510 ENOG4105G0J serine threonine protein kinase HC658_02530 ENOG4106K80 HC658_02550 ENOG4106DDH Sporulation-specific SASP protein HC658_02570 ENOG4108HWY Beta-lactamase HC658_02580 ENOG4107E6A Cytochrome p-450 HC658_02600 ENOG4107QTZ amino acid HC658_02610 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HC658_02620 ENOG4105CXY transporter HC658_02640 ENOG410645S MarR family Transcriptional regulator HC658_02650 ENOG4105DCM major facilitator superfamily HC658_02690 ENOG410631K Membrane HC658_02700 ENOG4106AXJ AraC family transcriptional regulator HC658_02710 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HC658_02720 ENOG4108TCS Glutamyl endopeptidase HC658_02740 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HC658_02750 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HC658_02760 ENOG4107ZTW SNARE associated Golgi HC658_02810 ENOG4105C72 UPF0176 protein HC658_02830 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane HC658_02840 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HC658_02870 ENOG4105CM2 brancheD-chain amino acid aminotransferase HC658_02880 ENOG4108IQI permease HC658_02890 ENOG4108J5H Homocysteine s-methyltransferase HC658_02910 ENOG4105CSV Glutaminase HC658_02940 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HC658_02950 ENOG4105C26 Dehydrogenase HC658_02960 ENOG4105DJB Major Facilitator Superfamily HC658_02970 ENOG4105EQX glucarate dehydratase HC658_02980 ENOG41073TP transcriptional regulator HC658_02990 ENOG4105CTX dehydratase HC658_03020 ENOG4106UX7 integral membrane protein HC658_03030 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HC658_03090 ENOG4105MUA Resistance protein HC658_03110 ENOG4105DGI Alkaline phosphatase HC658_03120 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HC658_03130 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HC658_03140 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HC658_03150 ENOG4107EPV Aminotransferase class V HC658_03160 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC658_03170 ENOG4105J7D transcriptional regulator HC658_03180 ENOG4107RB3 L-asparaginase HC658_03190 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HC658_03210 ENOG41060AI SEC-C motif HC658_03230 ENOG4107Y7X LytTR HC658_03240 ENOG4108IUW ABC transporter HC658_03250 ENOG4108SDH ABC, transporter HC658_03260 ENOG4107SET aldo keto reductase HC658_03320 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HC658_03340 ENOG4105DSE periplasmic solute binding protein HC658_03350 ENOG4105DIK (ABC) transporter HC658_03370 ENOG4105DEN Luciferase family HC658_03380 ENOG4108N0M stress protein HC658_03390 ENOG4106FN3 tellurium resistance protein HC658_03400 ENOG4106FN3 tellurium resistance protein HC658_03410 ENOG4107TS3 membrane protein, TerC HC658_03420 ENOG4108TTB tellurium resistance protein HC658_03440 ENOG41079KZ Major Facilitator Superfamily HC658_03450 ENOG4107XZQ multidrug resistance protein HC658_03460 ENOG4108A65 Transcriptional regulator HC658_03470 ENOG4108IJ7 Glycine betaine HC658_03480 ENOG4107SQ8 Glycine betaine HC658_03540 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HC658_03610 ENOG4105EIG urea carboxylase-associated protein 1 HC658_03620 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HC658_03630 ENOG4105I1F Resistance protein HC658_03640 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HC658_03650 ENOG41089UC methyltransferase, type 11 HC658_03660 ENOG4105C5Q Transcriptional regulator HC658_03670 ENOG4105I82 acetyl xylan esterase HC658_03680 ENOG410756H nucleotidyltransferase HC658_03700 ENOG4105C26 Dehydrogenase HC658_03710 ENOG4105CK7 Sodium proline symporter HC658_03720 ENOG4107YHD transcriptional regulator HC658_03740 ENOG4108PJD permease HC658_03750 ENOG4105U6C Alpha beta hydrolase fold protein HC658_03770 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HC658_03780 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HC658_03790 ENOG4108IFG nitrite reductase, (NAD(P)H) HC658_03800 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HC658_03840 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HC658_03860 ENOG4105CKI cobalamin synthesis protein HC658_03870 ENOG4105E5Q amino acid AbC transporter HC658_03880 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein HC658_03890 ENOG4105HHM rdd domain containing protein HC658_03910 ENOG4105CS2 ec 3.2.1.21 HC658_03940 ENOG4105C8Q Methyl-accepting chemotaxis HC658_03950 ENOG41080HJ 6-phospho 3-hexuloisomerase HC658_03960 ENOG4108VA3 3-hexulose-6-phosphate synthase HC658_03970 ENOG4105KVH Transcriptional regulator HC658_03980 ENOG4105CEY Amp-dependent synthetase and ligase HC658_04040 ENOG4105SX7 Transporter HC658_04060 ENOG4105W8Z 4'-phosphopantetheinyl transferase HC658_04080 ENOG4105CDA abc transporter atp-binding protein HC658_04090 ENOG4105DRP amino acid AbC transporter HC658_04110 ENOG4106P55 Transcriptional regulator HC658_04120 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HC658_04130 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HC658_04140 ENOG41069ZX HC658_04160 ENOG4105DUX Transporter HC658_04190 ENOG4105E1K spore germination protein HC658_04230 ENOG4107WD8 ABC transporter, permease HC658_04240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC658_04250 ENOG4105BZU Histidine kinase HC658_04280 ENOG4105CFH Aspartokinase HC658_04290 ENOG4105DHS permease protein HC658_04300 ENOG4105CM4 permease protein HC658_04310 ENOG4108IPW abc transporter atp-binding protein HC658_04340 ENOG4105R8C Transcriptional regulator HC658_04350 ENOG4108DBC nitroreductase HC658_04360 ENOG41067V3 Antibiotic biosynthesis monooxygenase HC658_04370 ENOG4105YVS arsR family transcriptional regulator HC658_04390 ENOG4108JPW Aminotransferase HC658_04400 ENOG4105C26 Dehydrogenase HC658_04420 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HC658_04430 ENOG4105KTB nuclear export factor GLE1 HC658_04440 ENOG4108T5E Copper resistance protein HC658_04450 ENOG4108ZYE Transcriptional regulator HC658_04500 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HC658_04520 ENOG4108ZX0 Signal peptidase I HC658_04570 ENOG4105E7W lamb ycsf family protein HC658_04580 ENOG4105C5A transporter HC658_04590 ENOG4105CFM UPF0317 protein HC658_04600 ENOG4105P4J Allophanate hydrolase, subunit 1 HC658_04620 ENOG4107258 Transcriptional regulator HC658_04630 ENOG4105XJB lipolytic protein G-D-S-L family HC658_04650 ENOG41061CK Antibiotic biosynthesis monooxygenase HC658_04660 ENOG4107RVG penicillin-binding protein HC658_04670 ENOG4107QM2 Aldo Keto reductase HC658_04680 ENOG4105ETD TRANSCRIPTIONal HC658_04700 ENOG4105HMZ Methyltransferase HC658_04710 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HC658_04740 ENOG410606W general stress protein HC658_04770 ENOG4105VCH membrane HC658_04790 ENOG4105C9U ATP-dependent DNA helicase RecQ HC658_04820 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HC658_04830 ENOG4107R8N Glycosyl transferase, family 2 HC658_04850 ENOG4105C0X amino acid HC658_04890 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HC658_04910 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HC658_04920 ENOG4105EU9 HC658_04930 ENOG4105QVS general stress protein HC658_04940 ENOG41082W1 Cupin 2, conserved barrel domain protein HC658_04970 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HC658_04980 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HC658_04990 ENOG4108MRH transcriptional regulatory protein HC658_05000 ENOG4107QJT sodium dicarboxylate symporter HC658_05010 ENOG4106F5Q Membrane HC658_05020 ENOG4105CJ1 ABC, transporter HC658_05050 ENOG4105FDT acyl-CoA dehydrogenase HC658_05090 ENOG4105SZ6 Thioredoxin HC658_05100 ENOG4105CPF Cell wall formation (By similarity) HC658_05110 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HC658_05120 ENOG4105C1J atp-dependent rna helicase HC658_05130 ENOG410905X membrane-flanked domain protein HC658_05140 ENOG4105CKV Membrane HC658_05160 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HC658_05170 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HC658_05180 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HC658_05200 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HC658_05210 ENOG4107MMM Anti-sigma-factor antagonist HC658_05220 ENOG4105FUA antagonist HC658_05230 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HC658_05240 ENOG4107SGM protein serine threonine phosphatase HC658_05250 ENOG4105WN5 stage II sporulation protein HC658_05260 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HC658_05280 ENOG41064BQ Phosphatase HC658_05410 ENOG4106BHF HC658_05420 ENOG4105VZ8 Transcriptional regulator HC658_05440 ENOG4105ECK Fatty Acid Desaturase HC658_05450 ENOG4105VEQ Cold shock protein HC658_05460 ENOG4108VJ1 Transcriptional regulator (CarD family HC658_05480 ENOG4108MCI Transcriptional regulator, ARAC family HC658_05490 ENOG4108UZ3 Transporter HC658_05500 ENOG41086D8 Transcriptional regulator HC658_05510 ENOG4107U9B transcriptional regulator HC658_05520 ENOG4105DXI Major Facilitator superfamily HC658_05540 ENOG4105CZ9 Domain of unknown function (DU1801) HC658_05550 ENOG4105GIG HC658_05570 ENOG4105KRI phosphocarrier protein (HPr HC658_05580 ENOG4105ST3 Transcriptional regulator HC658_05590 ENOG4105T38 integral membrane protein HC658_05600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC658_05610 ENOG4108ZMQ domain protein HC658_05620 ENOG4105MJ9 esterase HC658_05630 ENOG4107Z6X Transcriptional regulator HC658_05650 ENOG4105EQ0 Major Facilitator superfamily HC658_05660 ENOG4108JGH Tetr family transcriptional regulator HC658_05680 ENOG41082YX Transcriptional regulator, arsr family HC658_05690 ENOG4107R5R arsenical pump membrane protein HC658_05710 ENOG4105Z7P Acetyltransferase (GNAT) family HC658_05720 ENOG4107Y9U Membrane HC658_05740 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HC658_05750 ENOG4108ZHR arsR family transcriptional regulator HC658_05760 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HC658_05770 ENOG4105ENE Histidine kinase HC658_05780 ENOG4108VB1 regulatoR HC658_05790 ENOG4105EYF MMPL domain protein HC658_05800 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HC658_05810 ENOG4108UQV Membrane HC658_05820 ENOG4108Z5V transcriptional regulator, merr family HC658_05830 ENOG41076HS cation diffusion facilitator family transporter HC658_05840 ENOG4108TVJ Nitroreductase HC658_05850 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HC658_05860 ENOG4108VGI doxx family HC658_05870 ENOG4105XXY Thioredoxin HC658_05910 ENOG410900G Protein of unknown function (DUF421) HC658_05920 ENOG4108QY0 Membrane HC658_05960 ENOG4105PF9 Transcriptional regulator HC658_05980 ENOG4105WQG acetyltransferase HC658_06000 ENOG4105C85 amino acid HC658_06020 ENOG41062A4 Transcriptional regulator HC658_06030 ENOG4105EYF MMPL domain protein HC658_06040 ENOG4108TVJ Nitroreductase HC658_06050 ENOG4105FS7 Transcriptional regulator HC658_06060 ENOG4105C2C drug resistance transporter, Bcr CflA HC658_06080 ENOG4105DRR Transcriptional regulator, GntR family HC658_06090 ENOG4105VRS hydrolase family 18 HC658_06120 ENOG4105G6Z alkaline phosphatase HC658_06130 ENOG4108ZMX Domain of unknown function (DU1801) HC658_06150 ENOG4108YM7 Gcn5-related n-acetyltransferase HC658_06160 ENOG4107TVP HD domain protein HC658_06170 ENOG41090UD (LipO)protein HC658_06180 ENOG4105F27 Major Facilitator HC658_06190 ENOG4105VZJ PTS System HC658_06200 ENOG4105VCP PTS System HC658_06210 ENOG4105CK1 PTS System HC658_06220 ENOG4105CS2 ec 3.2.1.21 HC658_06230 ENOG4108TZY GntR Family Transcriptional Regulator HC658_06240 ENOG4105EVU fructokinase HC658_06250 ENOG4105DG6 mannose-6-phosphate isomerase HC658_06260 ENOG4105D3P Mannan endo-1,4-beta-mannosidase HC658_06350 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HC658_06360 ENOG4105K8N protein family UPF0079, ATPase HC658_06370 ENOG41072GX Peptidase M22 Glycoprotease HC658_06380 ENOG410801F ribosomal-protein-alanine acetyltransferase HC658_06390 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HC658_06400 ENOG4105C5H ABC transporter HC658_06410 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HC658_06420 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HC658_06430 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HC658_06440 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HC658_06460 ENOG4108TYN CAAX amino terminal protease family protein HC658_06480 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HC658_06510 ENOG4105DVF Cytosine-specific methyltransferase HC658_06520 ENOG4107RHI Cytosine-specific methyltransferase HC658_06570 ENOG4105PGZ NB-ARC domain HC658_06580 ENOG4105CPQ Dehydrogenase HC658_06590 ENOG4105CT4 transporter HC658_06610 ENOG41087YS Phage shock protein A HC658_06620 ENOG4105DQX Zinc finger domain HC658_06630 ENOG4108WV1 Pfam:DUF477 HC658_06650 ENOG4108ZMR Ion transport 2 domain-containing protein HC658_06660 ENOG4107QNK )-transporter HC658_06720 ENOG4107YUH hydrolase HC658_06740 ENOG4107STQ Multicopper oxidase HC658_06750 ENOG4105C85 amino acid HC658_06770 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HC658_06810 ENOG4105C7N Xanthine uracil vitamin C permease HC658_06860 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HC658_06870 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HC658_06880 ENOG4105C83 adenylosuccinate lyase HC658_06890 ENOG4105C8V SAICAR synthetase HC658_06900 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HC658_06910 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HC658_06920 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HC658_06940 ENOG4105CXB phosphoribosylaminoimidazole synthetase HC658_06950 ENOG4108V3E phosphoribosylglycinamide formyltransferase HC658_06960 ENOG4105DC1 bifunctional purine biosynthesis protein purh HC658_06970 ENOG4105C12 Phosphoribosylglycinamide synthetase HC658_06990 ENOG4105DVH amino acid HC658_07020 ENOG4108R5T secreted protein HC658_07030 ENOG4105KGF protein, YerC YecD HC658_07040 ENOG4105CBC glutamate synthase HC658_07050 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HC658_07060 ENOG4105C4R Atp-dependent dna helicase HC658_07070 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HC658_07090 ENOG4105CRN Aminoglycoside phosphotransferase HC658_07100 ENOG4105KT7 mgtC SapB transporter HC658_07110 ENOG4105CK7 Sodium proline symporter HC658_07120 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HC658_07130 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HC658_07140 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HC658_07150 ENOG4108IG5 Transcriptional regulator HC658_07170 ENOG4105CBD Diacylglycerol kinase HC658_07180 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HC658_07210 ENOG4105D85 methylase HC658_07220 ENOG4105F6A helicase HC658_07230 ENOG4105ECI YeeC-like protein HC658_07330 ENOG4105CDY transcriptional regulatory protein HC658_07350 ENOG4105M4P Tetr family transcriptional regulator HC658_07360 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HC658_07370 ENOG4107S9F NmrA family HC658_07400 ENOG4105WEF catalase HC658_07410 ENOG4105M18 -acetyltransferase HC658_07440 ENOG4105C2F Histidine kinase HC658_07450 ENOG4105EQD regulatoR HC658_07460 ENOG410769Z extracellular solute-binding protein family 1 HC658_07470 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HC658_07480 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HC658_07490 ENOG4105F5H Glycosyl Hydrolase Family 88 HC658_07500 ENOG41075H3 AraC family transcriptional regulator HC658_07510 ENOG4107TDE lipolytic protein G-D-S-L family HC658_07540 ENOG4105CX8 fg-gap repeat protein HC658_07550 ENOG4105CX8 fg-gap repeat protein HC658_07560 ENOG4107TDE lipolytic protein G-D-S-L family HC658_07580 ENOG4105EKC HC658_07590 ENOG4105E0S extracellular solute-binding protein family 1 HC658_07610 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HC658_07620 ENOG4105F8D glycoside hydrolase family 4 HC658_07630 ENOG4105H67 Protein of unknown function (DUF421) HC658_07640 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HC658_07650 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HC658_07690 ENOG4106I4J membrane HC658_07700 ENOG4108PCN EamA-like transporter family HC658_07710 ENOG41082F9 transcriptional regulator HC658_07720 ENOG41061H0 Monooxygenase HC658_07730 ENOG4108R1P HC658_07740 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HC658_07750 ENOG4105E0M Sulfatase HC658_07760 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HC658_07780 ENOG41090R9 glycosyltransferase HC658_07790 ENOG4107R51 Glycosyl transferase, family 2 HC658_07800 ENOG41090R9 glycosyltransferase HC658_07810 ENOG4105EU0 Major facilitator Superfamily HC658_07830 ENOG4105CUB amino acid HC658_07840 ENOG4105C26 Dehydrogenase HC658_07850 ENOG4105FKZ Methyl-accepting chemotaxis HC658_07860 ENOG4105C5H ABC transporter HC658_07880 ENOG4107SWG transcriptional regulator MERR family HC658_07890 ENOG4105DXB Major Facilitator superfamily HC658_07920 ENOG4105C5H ABC transporter HC658_07930 ENOG4105FDU atp-dependent rna helicase HC658_07950 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HC658_07980 ENOG4105E6M Sulphatase-modifying factor protein HC658_07990 ENOG4105E0A ABC, transporter HC658_08000 ENOG4108U1V ABC transporter, permease HC658_08010 ENOG4105DQ5 transport system permease protein HC658_08020 ENOG4108HUF Transporter HC658_08050 ENOG4108J20 pectate lyase HC658_08060 ENOG4107QPK )-transporter HC658_08080 ENOG4108MRH transcriptional regulatory protein HC658_08130 ENOG410855V Acylphosphatase HC658_08140 ENOG4108RPX mosc domain containing protein HC658_08180 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HC658_08230 ENOG4105GEU Spore germination protein HC658_08250 ENOG4108Q5U germination protein, ger(x)c family HC658_08260 ENOG4105E1K spore germination protein HC658_08270 ENOG4105C5Y PTS System HC658_08280 ENOG4105CG3 alpha amylase, catalytic region HC658_08290 ENOG4107414 GntR family transcriptional regulator HC658_08300 ENOG4108RCM Nitroreductase HC658_08310 ENOG4105CGH 5'-nucleotidase HC658_08320 ENOG4107RKG DJ-1/PfpI family HC658_08350 ENOG4105KJF protein tyrosine phosphatase HC658_08370 ENOG4107U9T Pfam:Ribonuclease_BN HC658_08380 ENOG4108ISG Major Facilitator HC658_08390 ENOG4105UPD Calcium Proton HC658_08410 ENOG4105D8X mechanosensitive ion channel HC658_08450 ENOG4106KE4 Dehydrogenase HC658_08460 ENOG4105D7N magnesium and cobalt transport protein CorA HC658_08480 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HC658_08530 ENOG4107RUY (E1 component), alpha subunit HC658_08550 ENOG4107QKR Dehydrogenase HC658_08570 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HC658_08580 ENOG41069DP small acid-soluble spore protein HC658_08590 ENOG4105KK4 UPF0060 membrane protein HC658_08650 ENOG4105F8D glycoside hydrolase family 4 HC658_08660 ENOG4108Q3X Transcriptional regulator HC658_08670 ENOG4105CI1 PTS System HC658_08680 ENOG4105BZ1 (ABC) transporter HC658_08690 ENOG4105BZ1 (ABC) transporter HC658_08710 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HC658_08720 ENOG4105ID8 Transcriptional regulator, ARAC family HC658_08730 ENOG4107QNK )-transporter HC658_08740 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HC658_08750 ENOG4105CIB oxidoreductase Domain protein HC658_08760 ENOG4105BZU Histidine kinase HC658_08770 ENOG4105WH1 Two component transcriptional regulator luxr family HC658_08780 ENOG4105CJ1 ABC, transporter HC658_08790 ENOG41090VJ ABC-2 type transporter HC658_08800 ENOG4108KYE ABC-2 type transporter HC658_08810 ENOG4105U3E Transcriptional regulator HC658_08820 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HC658_08830 ENOG4105H93 Acyltransferase family HC658_08840 ENOG4105YA8 Transcriptional regulator HC658_08850 ENOG4107Y80 Major Facilitator superfamily HC658_08860 ENOG4108YYS metal-dependent hydrolase (By similarity) HC658_08870 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC658_08880 ENOG410834F Transcriptional regulator HC658_08900 ENOG4108MES Periplasmic binding protein HC658_08910 ENOG4105DQ5 transport system permease protein HC658_08920 ENOG4108IHU transport system permease protein HC658_08930 ENOG4105JAB phenazine biosynthesis protein, phzf family HC658_08940 ENOG4107Y03 Nitroreductase HC658_08970 ENOG4105ECP epimerase HC658_09000 ENOG4105F27 Major Facilitator HC658_09040 ENOG4106AKJ HC658_09050 ENOG4105D74 hydrolase HC658_09060 ENOG4105CKK Glycosyl transferase, family 2 HC658_09070 ENOG4105EJV Membrane HC658_09080 ENOG41067AE Membrane-bound metal-dependent hydrolase HC658_09090 ENOG4105CEN a g-specific adenine glycosylase HC658_09100 ENOG4106BXE HC658_09110 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HC658_09140 ENOG4105EVI UPF0374 protein HC658_09150 ENOG4105BZ1 (ABC) transporter HC658_09160 ENOG4107NBY Membrane HC658_09180 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HC658_09190 ENOG4105G5W regulator Fur family HC658_09410 ENOG4108N23 SpoOM-related protein HC658_09440 ENOG4105EC3 peptidase S51, dipeptidase E HC658_09450 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HC658_09460 ENOG4105DNP FAD linked oxidase domain protein HC658_09490 ENOG4105E2Y ABC, transporter HC658_09500 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HC658_09510 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HC658_09520 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HC658_09540 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HC658_09550 ENOG4107D63 HC658_09560 ENOG4105VZ8 Transcriptional regulator HC658_09590 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HC658_09610 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HC658_09650 ENOG4105CYN Serine protein kinase HC658_09660 ENOG4106AKX UPF0229 protein HC658_09670 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HC658_09680 ENOG4105CW7 secretion protein, HlyD family HC658_09690 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC658_09700 ENOG4105CS1 NAD(P)H quinone oxidoreductase HC658_09740 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HC658_09750 ENOG4105CZV ABC transporter HC658_09760 ENOG4105CJ1 ABC, transporter HC658_09770 ENOG4108TU7 Inherit from COG: (ABC) transporter HC658_09780 ENOG4105VEQ Cold shock protein HC658_09800 ENOG4105BZU Histidine kinase HC658_09880 ENOG4108YBP pseudouridine synthase HC658_09900 ENOG41080XP Cbs domain HC658_09910 ENOG4107YBY Hydrolase HC658_09920 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HC658_09940 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HC658_09950 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HC658_09970 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HC658_09980 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HC658_10000 ENOG4105BZU Histidine kinase HC658_10010 ENOG4105WH1 Two component transcriptional regulator luxr family HC658_10080 ENOG4105ED1 spovr family HC658_10090 ENOG4105G6Z alkaline phosphatase HC658_10120 ENOG4105BZN citrate synthase HC658_10130 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HC658_10140 ENOG4105CUB amino acid HC658_10150 ENOG4105C8J )-transporter HC658_10160 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC658_10190 ENOG4105J37 HC658_10200 ENOG4108AEY RNA polymerase sigma factor HC658_10210 ENOG4108FN7 Aldo keto reductase HC658_10220 ENOG4105F6E Acyl-transferase HC658_10230 ENOG4105C37 (CBS) domain HC658_10250 ENOG4105CHM Aminotransferase HC658_10260 ENOG4105C37 (CBS) domain HC658_10280 ENOG4105WMR Protein CrcB homolog HC658_10290 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HC658_10310 ENOG4105D64 Mechanosensitive ion channel HC658_10320 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HC658_10330 ENOG4107VMI polysaccharide deacetylase HC658_10340 ENOG4105F0I Aminotransferase HC658_10380 ENOG4105BZ1 (ABC) transporter HC658_10390 ENOG4105BZ1 (ABC) transporter HC658_10440 ENOG410839P HC658_10460 ENOG4106MP8 UPF0754 membrane protein HC658_10470 ENOG4105WZB UPF0342 protein HC658_10480 ENOG4105F1N DNA alkylation repair HC658_10500 ENOG4105D4P Coproporphyrinogen iii oxidase HC658_10510 ENOG4107S91 Sodium hydrogen exchanger HC658_10520 ENOG4105NCW Trka-c domain protein HC658_10540 ENOG4105CGU Enoyl-CoA hydratase HC658_10560 ENOG4108IUX (ABC) transporter HC658_10570 ENOG4105RHA ABC transporter, permease HC658_10580 ENOG4107VRP DNA repair exonuclease HC658_10590 ENOG4106D4I domain protein HC658_10600 ENOG4105EQI Metal Dependent Phosphohydrolase HC658_10620 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HC658_10690 ENOG4105NBU tryptophan transport protein HC658_10700 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HC658_10710 ENOG4105K59 histidine triad (HIT) protein HC658_10770 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HC658_10780 ENOG4105BZ4 penicillin-binding protein HC658_10790 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HC658_10800 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HC658_10810 ENOG4105C1Q protoporphyrinogen oxidase HC658_10830 ENOG4105ECB domain protein HC658_10850 ENOG41090T1 Membrane HC658_10870 ENOG4105DER m42 family HC658_10900 ENOG4106AXD HC658_10910 ENOG4108RQ5 Beta-lactamase domain-containing protein HC658_10920 ENOG4105DF9 Lipoate-protein, ligase HC658_10940 ENOG4105CEY Amp-dependent synthetase and ligase HC658_10960 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HC658_10990 ENOG4105KD7 acetyltransferase HC658_11010 ENOG4108HUF Transporter HC658_11020 ENOG4107TB6 phosphoglycerate mutase HC658_11040 ENOG4107F3J Amp-dependent synthetase and ligase HC658_11050 ENOG4107ZYJ bioY protein HC658_11060 ENOG4106YBV Methyl-accepting chemotaxis HC658_11100 ENOG4105XVF Competence transcription factor HC658_11110 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HC658_11120 ENOG4105X3H Excalibur domain protein HC658_11130 ENOG4105E1V na solute symporter HC658_11140 ENOG4106CAD Protein of unknown function (DUF3311) HC658_11150 ENOG41060YP HC658_11180 ENOG4107SCK Monooxygenase HC658_11190 ENOG4108INS Transcriptional regulator HC658_11220 ENOG4105TRI Hydrolase HC658_11250 ENOG4108KK1 membrane protein AbrB duplication HC658_11260 ENOG4106K7D Major facilitator family transporter HC658_11270 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HC658_11310 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HC658_11330 ENOG4105EYH Exonuclease HC658_11430 ENOG4105ERH Fumarylacetoacetate hydrolase HC658_11450 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HC658_11470 ENOG4105CAQ asparagine synthetase HC658_11500 ENOG4105UQX Mate efflux family protein HC658_11510 ENOG4106HBX Transcriptional Regulator AraC Family HC658_11520 ENOG4105ETE Transcriptional regulator (LacI family HC658_11530 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HC658_11540 ENOG4105SF0 DinB family HC658_11550 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HC658_11560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC658_11570 ENOG4105MYW Pentapeptide repeat protein HC658_11580 ENOG4107S9D Alpha beta hydrolase HC658_11590 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HC658_11600 ENOG4107RIQ Sulfate adenylate transferase HC658_11610 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HC658_11620 ENOG4108N5B 2-phosphosulfolactate phosphatase HC658_11630 ENOG41061P3 phosphosulfolactate synthase HC658_11650 ENOG4105DIA mandelate racemase muconate lactonizing HC658_11660 ENOG4107RCC Major Facilitator Superfamily HC658_11670 ENOG4108SZE gCN5-related N-acetyltransferase HC658_11680 ENOG4105MA6 gCN5-related N-acetyltransferase HC658_11700 ENOG4108VPT UPF0234 protein HC658_11710 ENOG4105QNR S1 RNA binding domain protein HC658_11750 ENOG4105K7K Transcriptional regulator HC658_11770 ENOG410751J HC658_11780 ENOG4105D4Y metalloprotease HC658_11790 ENOG4105EPR degv family HC658_11800 ENOG4107AYK membrAne HC658_11820 ENOG41073B9 HC658_11830 ENOG4108KP7 hydrolase HC658_11840 ENOG4108MXZ Esterase HC658_11850 ENOG4105VG1 fes assembly suf system protein HC658_11870 ENOG4105IQ5 FAD linked oxidase domain protein HC658_11890 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HC658_11900 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HC658_11920 ENOG4105C8Y Acetylornithine aminotransferase HC658_11930 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HC658_11950 ENOG4105DBV ornithine carbamoyltransferase HC658_12000 ENOG4107RMD Basic membrane lipoprotein HC658_12030 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HC658_12040 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HC658_12060 ENOG4105C3U ABC transporter HC658_12070 ENOG4108JQ7 (ABC) transporter HC658_12100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC658_12120 ENOG4105C31 Tryptophanyl-tRNA synthetase HC658_12130 ENOG4108J59 Extracellular solute-binding protein, family 5 HC658_12140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC658_12150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC658_12170 ENOG4108JQ7 (ABC) transporter HC658_12200 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HC658_12210 ENOG4108ZCF integral membrane protein HC658_12220 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HC658_12240 ENOG4105DPN Oligoendopeptidase f HC658_12270 ENOG4105T58 Dithiol-disulfide isomerase HC658_12280 ENOG4108Z18 K06886 hemoglobin HC658_12290 ENOG4105E4C Lytic transglycosylase catalytic HC658_12300 ENOG4105MIX Adenylate cyclase HC658_12330 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HC658_12340 ENOG4105EMS pseudouridine synthase HC658_12370 ENOG4105ETU transcriptional activator (TenA HC658_12380 ENOG4108VEU Thiamine monophosphate synthase HC658_12410 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HC658_12420 ENOG4105D06 uba thif-type nad fad binding protein HC658_12430 ENOG4105DWF phosphomethylpyrimidine kinase HC658_12440 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HC658_12450 ENOG4107A88 HC658_12550 ENOG4105ENA helicase HC658_12580 ENOG4108ZMI UPF0477 protein HC658_12600 ENOG4105C28 cystathionine HC658_12610 ENOG4105C28 cystathionine HC658_12620 ENOG4105D9U N-acetyltransferase HC658_12630 ENOG4105JHY Membrane HC658_12670 ENOG4106BHF HC658_12730 ENOG4108PSK reductase HC658_12760 ENOG4105DM4 PTS System HC658_12770 ENOG4105DG6 mannose-6-phosphate isomerase HC658_12780 ENOG4105G7B Protein of unknown function (DUF2992) HC658_12790 ENOG4105VMI -acetyltransferase HC658_12810 ENOG4108Z66 YbaK ebsC protein HC658_12840 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HC658_12860 ENOG4108ZJ4 polysaccharide deacetylase HC658_12870 ENOG4107CUJ Protein of unknown function (DUF2690) HC658_12920 ENOG4108IEG Formate dehydrogenase Alpha subunit HC658_12970 ENOG4106A3M Cytochrome p-450 HC658_12980 ENOG41087PP glycosyltransferase MGT family HC658_13000 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HC658_13010 ENOG4105C4B ABC transporter, permease HC658_13020 ENOG4108IXI (ABC) transporter HC658_13040 ENOG4105Q95 Cupin 2, conserved barrel domain protein HC658_13070 ENOG4105D2H Uronic isomerase HC658_13080 ENOG4105CT4 transporter HC658_13090 ENOG4105DG4 malate L-lactate dehydrogenase HC658_13100 ENOG4105CPQ Dehydrogenase HC658_13110 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HC658_13120 ENOG4105DMW Dehydrogenase reductase HC658_13130 ENOG4108I5G Major Facilitator superfamily HC658_13140 ENOG4107KJX Transcriptional regulator HC658_13150 ENOG4107QZW Altronate oxidoreductase HC658_13160 ENOG4105CTX dehydratase HC658_13170 ENOG4107TSN permease HC658_13190 ENOG4105JD4 ATPase yjob HC658_13220 ENOG41068K0 YCII-related domain HC658_13230 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HC658_13240 ENOG4105KWG Pfam:DUF1696 HC658_13250 ENOG4105K7W phage-related replication protein HC658_13260 ENOG4105WEF catalase HC658_13270 ENOG410635T phage-like element pbsx protein HC658_13360 ENOG4108TFU terminase (Small subunit) HC658_13370 ENOG4105IG6 Phage terminase, large subunit HC658_13380 ENOG4108MDF Phage Portal Protein HC658_13430 ENOG41060SN HC658_13460 ENOG4105PQS phage protein HC658_13470 ENOG4105FR7 XkdM protein, phage-like element PBSX HC658_13480 ENOG4105MTC XkdN-like protein HC658_13490 ENOG4108FKH Transglycosylase SLT domain HC658_13500 ENOG4108WZM domain protein HC658_13510 ENOG4105X7F HC658_13530 ENOG4105MFU Protein of unknown function (DUF2634) HC658_13540 ENOG41066EA baseplate J family protein HC658_13550 ENOG410906S phage-like element pbsx protein xkdt HC658_13570 ENOG41068G1 HC658_13630 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HC658_13670 ENOG4105CJ3 phosphate transporter HC658_13680 ENOG4107GRR phosphate transport regulator HC658_13690 ENOG4107R7I amino acid HC658_13710 ENOG4105EDW glycosyl transferase, family 39 HC658_13720 ENOG4105CKK Glycosyl transferase, family 2 HC658_13730 ENOG4105C0H protease HC658_13750 ENOG4108ME1 Peptidase M55 D-aminopeptidase HC658_13760 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC658_13770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC658_13780 ENOG4105C3U ABC transporter HC658_13800 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HC658_13810 ENOG4105DTQ mandelate racemase muconate lactonizing HC658_13820 ENOG4107SN7 NLP P60 protein HC658_13830 ENOG4108JQ7 (ABC) transporter HC658_13840 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HC658_13850 ENOG4107TUM Amidinotransferase HC658_13860 ENOG4108S4H thioesterase Superfamily protein HC658_13870 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HC658_13910 ENOG4108428 Inherit from COG: -acetyltransferase HC658_13930 ENOG41080TC multidrug resistance protein HC658_13940 ENOG4105CIY formyltetrahydrofolate deformylase HC658_13950 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HC658_13980 ENOG4105K56 Transcriptional regulator HC658_13990 ENOG4108ZHJ Organic hydroperoxide resistance protein HC658_14010 ENOG4107Y2X deaminase HC658_14020 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HC658_14030 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HC658_14050 ENOG4108W7F transporter, permease HC658_14060 ENOG4108JJB ABC transporter HC658_14070 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HC658_14080 ENOG4108X43 YKOF domain protein HC658_14090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC658_14100 ENOG41062D9 Histidine kinase HC658_14120 ENOG4106849 propeptide, pepSY amd peptidase M4 HC658_14140 ENOG4105CJW magnesium transporter HC658_14150 ENOG4105V75 Transcriptional regulator HC658_14240 ENOG4105DQE DNA ligase HC658_14250 ENOG4105FDF Could be involved in DNA repair (By similarity) HC658_14260 ENOG4105BZU Histidine kinase HC658_14270 ENOG4107T5V SNARE associated Golgi HC658_14280 ENOG4107TS3 membrane protein, TerC HC658_14290 ENOG4108WZW RNA polymerase sigma HC658_14310 ENOG410681C small acid-soluble spore protein HC658_14330 ENOG4105D0M Protease HtpX homolog HC658_14370 ENOG4108TGC Acyltransferase HC658_14380 ENOG4105BZU Histidine kinase HC658_14390 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HC658_14400 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HC658_14410 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HC658_14420 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HC658_14440 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit HC658_14450 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HC658_14460 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HC658_14470 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HC658_14510 ENOG4105BZU Histidine kinase HC658_14520 ENOG41090MY MarR family Transcriptional regulator HC658_14530 ENOG4105ER2 Ompa motb domain protein HC658_14540 ENOG4105E14 MotA TolQ exbB proton channel HC658_14560 ENOG4108K88 Membrane HC658_14570 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HC658_14580 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HC658_14590 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HC658_14600 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HC658_14620 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HC658_14630 ENOG4105FEA Spore maturation protein HC658_14690 ENOG4105F0V Cell wall hydrolase HC658_14720 ENOG4105C59 p-type ATPase HC658_14740 ENOG4105DC7 peptidase M24 HC658_14760 ENOG4105CID antiterminator HC658_14780 ENOG4105KRI phosphocarrier protein (HPr HC658_14790 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HC658_14810 ENOG4105F6S Spore photoproduct lyase HC658_14830 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HC658_14840 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HC658_14850 ENOG4105K4I Scp-like extracellular HC658_14870 ENOG4105BZU Histidine kinase HC658_14880 ENOG4105CHM Aminotransferase HC658_14900 ENOG4107R88 Chemotaxis protein (CheV) HC658_14910 ENOG4105UIN HC658_14930 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HC658_14950 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HC658_14960 ENOG4105EPM Diguanylate phosphodiesterase HC658_14990 ENOG4107IN1 Protein of unknown function (DUF1797) HC658_15000 ENOG4108XRC Protein of unknown function (DUF458) HC658_15060 ENOG4105NQC Flavodoxin HC658_15080 ENOG4105CH2 amidohydrolase HC658_15100 ENOG4105D8X mechanosensitive ion channel HC658_15110 ENOG4105D3R alkyl hydroperoxide reductase HC658_15120 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HC658_15150 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HC658_15160 ENOG4105D06 uba thif-type nad fad binding protein HC658_15170 ENOG4105CVM Molybdenum cofactor synthesis domain protein HC658_15180 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HC658_15190 ENOG4108ZAF Molybdopterin HC658_15200 ENOG41067WU Molybdopterin converting factor (Subunit 1) HC658_15210 ENOG4105BZ1 (ABC) transporter HC658_15220 ENOG4105BZ1 (ABC) transporter HC658_15240 ENOG4107X8C Efflux transporter RND family MFP subunit HC658_15250 ENOG4105C19 ABC transporter HC658_15260 ENOG4107RBB ABC transporter, permease HC658_15270 ENOG4105E98 transcriptional regulator DeoR family HC658_15280 ENOG4105DE4 1-phosphofructokinase HC658_15290 ENOG4105DM4 PTS System HC658_15300 ENOG4105C3F Signal peptidase i HC658_15320 ENOG4105C5H ABC transporter HC658_15330 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HC658_15370 ENOG4105BZU Histidine kinase HC658_15390 ENOG4107ZYR domain protein HC658_15410 ENOG4105CN5 Metallo-Beta-Lactamase HC658_15430 ENOG4108X4Q Hydrolase HC658_15440 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HC658_15470 ENOG4105CPP Dehydrogenase, E1 component HC658_15480 ENOG4105C7S Dehydrogenase HC658_15490 ENOG4107QN2 dihydrolipoyl dehydrogenase HC658_15540 ENOG4105CXN decarboxylase HC658_15550 ENOG4105WBI UPF0223 protein HC658_15580 ENOG4105ECY inositol monophosphatase HC658_15600 ENOG4105JQZ Methyltransferase HC658_15680 ENOG4105CI3 gtp-binding protein typa HC658_15690 ENOG4105QA2 HC658_15720 ENOG4108IAB Phoh family HC658_15740 ENOG4105CSV Glutaminase HC658_15750 ENOG4105ZPI UPF0358 protein HC658_15760 ENOG4105CNI cell division protein FtsW HC658_15770 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HC658_15790 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HC658_15810 ENOG4105BZ9 Cytochrome C oxidase, subunit I HC658_15820 ENOG4105CCU oxidase (Subunit III) HC658_15830 ENOG41064X9 cytochrome C oxidase subunit IV HC658_15860 ENOG41080XQ Signal transduction protein with cbs domains HC658_15870 ENOG4106UY4 Inherit from COG: Scp-like extracellular HC658_15910 ENOG4105WUC UPF0298 protein HC658_15930 ENOG4106H78 methyltransferase HC658_15940 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HC658_15950 ENOG4105H20 Sporulation integral membrane protein YlbJ HC658_15960 ENOG4105D78 K07001 NTE family protein HC658_15970 ENOG41063PX domain protein HC658_15980 ENOG4105CDE UPF0348 protein HC658_16000 ENOG4105KNH Nucleic acid-binding protein HC658_16060 ENOG4108V6E Cell division protein mraZ HC658_16070 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HC658_16090 ENOG4105CJN penicillin-binding protein HC658_16100 ENOG4105CJN penicillin-binding protein HC658_16110 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HC658_16120 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HC658_16130 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HC658_16140 ENOG4105CNI cell division protein FtsW HC658_16150 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HC658_16160 ENOG4105D4A Cell wall formation (By similarity) HC658_16170 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HC658_16180 ENOG4108R2U division initiation protein HC658_16200 ENOG4105K67 small basic protein HC658_16210 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HC658_16220 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HC658_16240 ENOG4105FFI sigma-e processing peptidase spoiiga HC658_16250 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC658_16270 ENOG4105DKW ABC transporter HC658_16290 ENOG4105WR5 sporulation protein, YlmC YmxH family HC658_16300 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HC658_16310 ENOG4105DFA alanine racemase domain protein HC658_16320 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HC658_16330 ENOG41067XK integral membrane protein HC658_16340 ENOG4105DBK s4 domain protein HC658_16360 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HC658_16380 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HC658_16390 ENOG4105C34 Pseudouridine synthase HC658_16400 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HC658_16420 ENOG4105CXT aspartate transcarbamylase HC658_16440 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HC658_16450 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HC658_16460 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HC658_16470 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HC658_16480 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HC658_16490 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HC658_16500 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HC658_16520 ENOG4107S4M Sulfate adenylate transferase HC658_16530 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HC658_16540 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HC658_16550 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HC658_16560 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HC658_16590 ENOG4105DSJ YicC domain protein HC658_16600 ENOG4105KC4 UPF0296 protein HC658_16610 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HC658_16630 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HC658_16640 ENOG4105C25 Primosomal protein n' HC658_16650 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HC658_16660 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HC658_16670 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HC658_16680 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HC658_16690 ENOG4108ZF3 Phosphatase HC658_16700 ENOG4105D9P serine threonine protein kinase HC658_16710 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HC658_16720 ENOG4105DJV ribulose-phosphate 3-epimerase HC658_16730 ENOG4105FJ0 thiamine HC658_16740 ENOG4105VB9 50S ribosomal protein l28 HC658_16750 ENOG4108ZAA Alkaline-shock protein HC658_16760 ENOG4105DP4 dak2 domain fusion protein ylov HC658_16780 ENOG4105EJQ L-serine dehydratase HC658_16790 ENOG4105CB5 ATP-dependent DNA helicase recG HC658_16800 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HC658_16820 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HC658_16830 ENOG4105CHR reductase HC658_16850 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HC658_16860 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HC658_16870 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HC658_16890 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HC658_16910 ENOG4105K5M 30s ribosomal protein S16 HC658_16920 ENOG4108BW8 UPF0109 protein HC658_16940 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HC658_16950 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HC658_16960 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HC658_16970 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HC658_16980 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HC658_17000 ENOG4105VM1 flagellar HC658_17010 ENOG4105CMV Succinyl-CoA synthetase subunit beta HC658_17020 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HC658_17030 ENOG4105C79 DNA protecting protein DprA HC658_17040 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HC658_17050 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HC658_17060 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HC658_17070 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HC658_17080 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HC658_17100 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HC658_17110 ENOG4108ZC9 flagellar basal-body rod protein flgc HC658_17120 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HC658_17130 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HC658_17140 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HC658_17170 ENOG4106YF4 Flagellar biosynthesis chaperone HC658_17190 ENOG410696Y Flagellar hook-length control protein HC658_17200 ENOG410822I Flagellar hook capping protein HC658_17210 ENOG4108JQA flagellar HC658_17220 ENOG41068WV flagellar FlbD family protein HC658_17240 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HC658_17250 ENOG4105DD5 Flagellar motor switch protein HC658_17260 ENOG4107YTP response regulator receiver protein HC658_17280 ENOG4105CN7 Flagellar biosynthetic protein FliP HC658_17290 ENOG4105VS8 Flagellar biosynthetic protein fliq HC658_17300 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HC658_17310 ENOG4105D00 flagellar biosynthetic protein flhB HC658_17320 ENOG4105D7B Flagellar biosynthesis protein flha HC658_17330 ENOG4105FZW flagellar biosynthesis regulator FlhF HC658_17350 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HC658_17360 ENOG4105CBS Chea signal transduction histidine kinase HC658_17370 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HC658_17400 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC658_17420 ENOG4105CE9 30S ribosomal protein S2 HC658_17430 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HC658_17450 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HC658_17460 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HC658_17470 ENOG4105KNE Phosphatidate cytidylyltransferase HC658_17490 ENOG4105DZP Membrane-associated zinc metalloprotease HC658_17500 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HC658_17510 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HC658_17530 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HC658_17540 ENOG4105CHV Transcription elongation factor NusA HC658_17550 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HC658_17560 ENOG4105VHM ribosomal protein HC658_17570 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HC658_17580 ENOG4105W7A Protein of unknown function (DUF503) HC658_17590 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HC658_17600 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HC658_17610 ENOG4105DTN riboflavin biosynthesis protein ribF HC658_17620 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HC658_17630 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HC658_17650 ENOG4105C1V Peptidase, M16 HC658_17670 ENOG4105E35 Dipicolinate synthase subunit A HC658_17680 ENOG4108S0H Dipicolinic acid synthetase, b subunit HC658_17690 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HC658_17710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HC658_17730 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HC658_17750 ENOG4105CNU cell division protein FtsK HC658_17760 ENOG4105FDP GntR family transcriptional regulator HC658_17800 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HC658_17810 ENOG4105XZV Protein of unknown function (DUF3243) HC658_17840 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HC658_17850 ENOG4105CEV competence damage-inducible protein HC658_17870 ENOG4108A04 Beta-lactamase HC658_17880 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HC658_17890 ENOG4105D48 metallophosphoesterase HC658_17900 ENOG4105MCT stage V sporulation protein S HC658_17920 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HC658_17930 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HC658_17960 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HC658_17970 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HC658_17990 ENOG4105IIP Membrane HC658_18000 ENOG4105W1N transcriptional regulator HC658_18010 ENOG4108151 Beta-lactamase domain protein HC658_18020 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HC658_18040 ENOG4107QKG PfaD family HC658_18050 ENOG41062T2 Acyl carrier protein HC658_18060 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase HC658_18070 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HC658_18080 ENOG4108MGH Enoyl-CoA hydratase HC658_18090 ENOG4108KQ6 Enoyl-CoA hydratase HC658_18100 ENOG4105C0W non-ribosomal peptide synthetase HC658_18110 ENOG4107SQU synthase HC658_18130 ENOG4105C0W non-ribosomal peptide synthetase HC658_18150 ENOG4106A3M Cytochrome p-450 HC658_18180 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HC658_18200 ENOG4105K7W phage-related replication protein HC658_18210 ENOG4108X3M OsmC Ohr family protein HC658_18220 ENOG410814C multidrug resistance protein HC658_18260 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HC658_18270 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HC658_18300 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HC658_18310 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC658_18320 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC658_18330 ENOG4105U6W MutT NUDIX family protein HC658_18340 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC658_18360 ENOG4106F1P AAA ATPase, central domain protein HC658_18370 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HC658_18380 ENOG4105CXI aluminum resistance protein HC658_18390 ENOG4105KV4 Transcriptional regulator HC658_18400 ENOG4105C5F glutamine synthetase HC658_18440 ENOG4107AUC HC658_18500 ENOG410907G HC658_18510 ENOG4105CT4 transporter HC658_18520 ENOG4105DSG hydrolase family 43 HC658_18530 ENOG4105E2R ROK family HC658_18540 ENOG4105C93 Xylose Isomerase HC658_18550 ENOG4105CMG Carbohydrate kinase HC658_18570 ENOG4107Y9E nuclease HC658_18580 ENOG4105C54 Major Facilitator superfamily HC658_18590 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HC658_18610 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HC658_18730 ENOG4108Q8B Spore germination protein HC658_18740 ENOG4108NHD germination protein HC658_18770 ENOG4105FVX HC658_18800 ENOG4105K7W phage-related replication protein HC658_18820 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HC658_18850 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HC658_18870 ENOG4108SVB resolvase HC658_18880 ENOG4105VPS UPF0291 protein HC658_18890 ENOG4105CV1 Transketolase (EC 2.2.1.1) HC658_18930 ENOG4107QIV Cytochrome c biogenesis protein HC658_18980 ENOG4107DZX Small, acid-soluble spore protein P HC658_19000 ENOG4108I0Z Aconitate hydratase HC658_19010 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HC658_19040 ENOG41067CD Small, acid-soluble spore protein Tlp HC658_19060 ENOG4105MI2 HC658_19070 ENOG4105W8X HesB YadR YfhF-family protein HC658_19080 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HC658_19090 ENOG4105K4P CoA-binding domain protein HC658_19100 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC658_19150 ENOG4107QWR cellulase (EC 3.2.1.4) HC658_19170 ENOG4108MYR Secreted protein HC658_19180 ENOG4107SYN Glycosyl hydrolases family 43 HC658_19200 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HC658_19210 ENOG4107T5V SNARE associated Golgi HC658_19230 ENOG4107QX3 carboxylase HC658_19240 ENOG4105E39 Enoyl-CoA hydratase HC658_19250 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HC658_19260 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HC658_19270 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HC658_19280 ENOG4105CEY Amp-dependent synthetase and ligase HC658_19290 ENOG4105C1G acyl-Coa dehydrogenase HC658_19310 ENOG4105F32 YngK protein HC658_19320 ENOG4106U2H Protein of unknown function (DUF1360) HC658_19340 ENOG4105CEY Amp-dependent synthetase and ligase HC658_19350 ENOG4105C0W non-ribosomal peptide synthetase HC658_19370 ENOG4105C0W non-ribosomal peptide synthetase HC658_19380 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HC658_19390 ENOG4108N2V aldose 1-epimerase HC658_19400 ENOG4107QJQ Mate efflux family protein HC658_19450 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HC658_19460 ENOG4105SKE transcriptional Regulator LysR family HC658_19470 ENOG4105CB2 alcohol dehydrogenase HC658_19480 ENOG4105BZ8 glutamate synthase HC658_19490 ENOG4105CBC glutamate synthase HC658_19500 ENOG4105C5Q Transcriptional regulator HC658_19510 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HC658_19520 ENOG4105II7 pyrroline-5-carboxylate reductase HC658_19560 ENOG4108UB7 HC658_19570 ENOG41068WN HC658_19580 ENOG4105IE8 Alpha-ketoglutarate permease HC658_19590 ENOG4107U6E carbohydrate kinase FGGY HC658_19600 ENOG4108M3J Dehydrogenase HC658_19610 ENOG4108J2R molybdopterin oxidoreductase HC658_19660 ENOG4105EC8 Methyl-accepting chemotaxis HC658_19680 ENOG4108YQE rare lipoprotein a HC658_19690 ENOG4105XPP Protein of unknown function (DUF1275) HC658_19700 ENOG4108NR7 pectate lyase HC658_19710 ENOG4108RAV Conserved protein HC658_19730 ENOG4105F0F Oxalate decarboxylase HC658_19750 ENOG4105EPI acetyltransferase, (GNAT) family HC658_19770 ENOG41073R8 VanW family HC658_19790 ENOG4105VMP Transcriptional regulator HC658_19800 ENOG4105NX3 Membrane HC658_19820 ENOG4108Q5Y Membrane HC658_19840 ENOG4108V4B ThiJ pfpI HC658_19850 ENOG4108J4B Beta-lactamase HC658_19880 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HC658_19900 ENOG4107T94 Endo-14-beta-xylanase HC658_19910 ENOG4105YB8 TM2 domain containing protein HC658_19920 ENOG4108IMY Transcriptional regulator HC658_19950 ENOG4108RAV Conserved protein HC658_19960 ENOG41079CX HC658_20000 ENOG410780I phosphoprotein phosphatase activity HC658_20020 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC658_20030 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC658_20060 ENOG4105DB4 HC658_20100 ENOG4106ANW SMI1_KNR4 HC658_20110 ENOG4106BHF HC658_20160 ENOG4108Z7R Chaperone CsaA HC658_20170 ENOG4105FTV AraC Family Transcriptional Regulator HC658_20180 ENOG4108HJF gCN5-related N-acetyltransferase HC658_20200 ENOG4108W8B Beta-lactamase domain protein HC658_20220 ENOG4105D29 Helix-turn-helix type 11 domain protein HC658_20240 ENOG4105KTU Transcriptional regulator, arsr family HC658_20260 ENOG4108SJC Membrane HC658_20300 ENOG4105ECK Fatty Acid Desaturase HC658_20310 ENOG4108ZGX Histidine kinase HC658_20320 ENOG4108S01 response regulator HC658_20330 ENOG41069ER domain protein HC658_20340 ENOG4105C9U ATP-dependent DNA helicase RecQ HC658_20370 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HC658_20380 ENOG4105SCY DNAK suppressor HC658_20460 ENOG4105C26 Dehydrogenase HC658_20470 ENOG4105EWU Squalene--hopene cyclase HC658_20480 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HC658_20490 ENOG4105C8J )-transporter HC658_20500 ENOG4105C09 Bile acid HC658_20510 ENOG4105C7S Dehydrogenase HC658_20530 ENOG4107T89 von Willebrand factor, type A HC658_20540 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HC658_20560 ENOG4105K4H Nlp p60 protein HC658_20570 ENOG41087PP glycosyltransferase MGT family HC658_20590 ENOG4107QMU Mate efflux family protein HC658_20600 ENOG4106SCS STAS domain HC658_20640 ENOG4105FR1 rard protein HC658_20670 ENOG4105C6Z Gluconate HC658_20680 ENOG41090U3 tautomerase HC658_20720 ENOG4105FBA Phospholipase Carboxylesterase HC658_20750 ENOG4105E1V na solute symporter HC658_20790 ENOG4108VXD carboxy-peptidase HC658_20800 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HC658_20820 ENOG4106Z5R HC658_20830 ENOG410841Q phosphoesterase PA-phosphatase related protein HC658_20890 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HC658_20900 ENOG4108TSC N-acetyltransferase HC658_20910 ENOG4107S4Y M20 DapE family protein YgeY HC658_20940 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HC658_21010 ENOG4107T32 3-phytase (EC 3.1.3.8) HC658_21020 ENOG4105C5E polysaccharide biosynthesis protein HC658_21030 ENOG4105E0X reductase HC658_21040 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HC658_21080 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HC658_21090 ENOG41090WU lipolytic protein G-D-S-L family HC658_21100 ENOG4108KF3 Electron transport protein SCO1 SenC HC658_21120 ENOG4105C7B Threonine dehydratase HC658_21140 ENOG4108UT2 hemolysin iii HC658_21160 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HC658_21170 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HC658_21200 ENOG4107YX5 Pfam:DUF548 HC658_21210 ENOG4108Y6J UPF0403 protein HC658_21220 ENOG4105C01 Dihydroxy-acid dehydratase HC658_21250 ENOG4108V06 Glutathione peroxidase HC658_21260 ENOG4105CVG Homoserine O-transsuccinylase HC658_21340 ENOG41081VK Ribonuclease HC658_21390 ENOG410890F Dynamin family HC658_21410 ENOG41065KQ synthase HC658_21420 ENOG4105C2W permease HC658_21430 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HC658_21440 ENOG4105CTD carboxy-peptidase HC658_21450 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HC658_21460 ENOG4108UHU Aldolase HC658_21470 ENOG4105D7K pfkb domain protein HC658_21480 ENOG4108M60 Transcriptional regulator HC658_21500 ENOG4105CHR reductase HC658_21510 ENOG4105DVT helicase HC658_21530 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HC658_21550 ENOG4108UKS UPF0398 protein HC658_21560 ENOG4107X2U Inherit from COG: Exonuclease-like protein HC658_21570 ENOG4108I5C dEAD DEAH box helicase HC658_21670 ENOG4105BZ4 penicillin-binding protein HC658_21690 ENOG4105CSM endonuclease III HC658_21710 ENOG4105C5S asparaginyl-tRNA synthetase HC658_21720 ENOG4105CHM Aminotransferase HC658_21740 ENOG4105YAC HC658_21750 ENOG4105DVT helicase HC658_21760 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HC658_21770 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HC658_21780 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HC658_21790 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HC658_21800 ENOG4105DJ0 Poly(A) Polymerase HC658_21810 ENOG4105CPK Glycosyl transferase (Group 1 HC658_21820 ENOG4105FJR Lmbe family HC658_21830 ENOG4108Z5K methylglyoxal synthase HC658_21840 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HC658_21850 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HC658_21860 ENOG4108JYZ YitT family HC658_21900 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HC658_21940 ENOG41068YB TPR repeat-containing protein HC658_21950 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HC658_21970 ENOG4105CIH Imidazole acetol-phosphate transaminase HC658_21990 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HC658_22000 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HC658_22020 ENOG4108I0Q anthranilate phosphoribosyltransferase HC658_22030 ENOG4105CRQ synthase (Component I) HC658_22040 ENOG4105KHN chorismate mutase HC658_22050 ENOG4105D49 3-dehydroquinate synthase HC658_22060 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HC658_22070 ENOG4105BZU Histidine kinase HC658_22080 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HC658_22090 ENOG4105EAH synthase HC658_22100 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HC658_22110 ENOG4105XXQ heptaprenyl diphosphate synthase component I HC658_22130 ENOG4105EUJ GTP cyclohydrolase i HC658_22140 ENOG4105K70 DNA-binding protein HC658_22150 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HC658_22180 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HC658_22190 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HC658_22200 ENOG41065D1 HC658_22210 ENOG4105S2F HC658_22240 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HC658_22250 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HC658_22260 ENOG4105CAT Cytidine monophosphate kinase HC658_22290 ENOG4105MSI germination protein ypeb HC658_22310 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HC658_22320 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HC658_22350 ENOG4107RGJ metallophosphoesterase HC658_22380 ENOG4105I7S Abortive infection protein HC658_22390 ENOG4105C9U ATP-dependent DNA helicase RecQ HC658_22400 ENOG4105T7X HC658_22420 ENOG4108SAX Membrane HC658_22430 ENOG4108JQ1 Dehydrogenase HC658_22440 ENOG4105FF2 Type I DHQase HC658_22470 ENOG4105BZU Histidine kinase HC658_22480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC658_22490 ENOG4105CRE cytochrome C HC658_22500 ENOG4107TWT Cytochrome c biogenesis protein HC658_22520 ENOG4105FE9 pseudouridine synthase HC658_22540 ENOG4108JIC nucleoside recognition domain protein HC658_22550 ENOG4105DZ1 carboxypeptidase HC658_22570 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HC658_22580 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HC658_22610 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HC658_22620 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HC658_22630 ENOG4108R6K riboflavin synthase, subunit alpha HC658_22640 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HC658_22660 ENOG4105C3F Signal peptidase i HC658_22670 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) HC658_22710 ENOG4107ZE5 PPIases accelerate the folding of proteins HC658_22720 ENOG4105PTM secreted protein HC658_22730 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HC658_22750 ENOG4105G6R Stage v sporulation protein ae HC658_22770 ENOG4105CZ3 stage V sporulation protein ad HC658_22780 ENOG41090VF Stage v sporulation protein ac HC658_22810 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC658_22820 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HC658_22830 ENOG41082AN stage II sporulation protein HC658_22840 ENOG4105DZ1 carboxypeptidase HC658_22850 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HC658_22860 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HC658_22870 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HC658_22890 ENOG4105I3K Ferric uptake regulator, Fur family HC658_22900 ENOG4105MZ9 stage II sporulation protein m HC658_22930 ENOG4105DFD Na H antiporter HC658_22940 ENOG4108IJ0 Aspartate ammonia-lyase HC658_22950 ENOG4105HDK L-asparaginase HC658_22960 ENOG4108IMY Transcriptional regulator HC658_22980 ENOG4108YZ4 nudix hydrolase HC658_23000 ENOG4105CPC Aldo Keto reductase HC658_23040 ENOG4106HZJ HC658_23050 ENOG4105RHY Pfam:UPF0157 HC658_23060 ENOG4105KAC Antibiotic biosynthesis monooxygenase HC658_23070 ENOG4108XET gCN5-related N-acetyltransferase HC658_23090 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC658_23120 ENOG4105E5W Transporter HC658_23140 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HC658_23170 ENOG4108IXY short-chain dehydrogenase reductase HC658_23180 ENOG41069FQ Metallo-beta-lactamase superfamily HC658_23190 ENOG4105II7 pyrroline-5-carboxylate reductase HC658_23210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HC658_23230 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HC658_23240 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HC658_23250 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HC658_23260 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC658_23280 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HC658_23290 ENOG4108NA0 Uncharacterized conserved protein (COG2071) HC658_23300 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HC658_23310 ENOG4108HNZ carboxyl transferase HC658_23320 ENOG4108ZVT methylmalonyl-coA epimerase HC658_23330 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HC658_23340 ENOG4108QEG Membrane HC658_23350 ENOG4105CDA abc transporter atp-binding protein HC658_23360 ENOG4105E5Q amino acid AbC transporter HC658_23370 ENOG4108HW3 (ABC) transporter HC658_23380 ENOG4108Y6J UPF0403 protein HC658_23390 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HC658_23420 ENOG4105C7S Dehydrogenase HC658_23430 ENOG4105CPP Dehydrogenase, E1 component HC658_23460 ENOG4105CKM Branched-chain carboxylic acid kinase HC658_23470 ENOG4107RDP Dehydrogenase HC658_23490 ENOG4108JUB Transcriptional regulator HC658_23500 ENOG4106CCJ Protein of unknown function (DUF2627) HC658_23510 ENOG4105CR4 methylisocitrate lyase HC658_23520 ENOG4105DXD 2-methylcitrate dehydratase HC658_23540 ENOG4105C1G acyl-Coa dehydrogenase HC658_23550 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HC658_23570 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HC658_23580 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC658_23600 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HC658_23610 ENOG4107QQR Sporulation HC658_23630 ENOG4105S1Z Stage IV sporulation protein B HC658_23640 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HC658_23650 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HC658_23660 ENOG4105DX0 Hemolysin A HC658_23680 ENOG4105CTB Polyprenyl synthetase HC658_23690 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HC658_23700 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HC658_23710 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HC658_23720 ENOG4105M7K Involved in the transcription termination process (By similarity) HC658_23730 ENOG4108ZSR alkaline shock protein HC658_23740 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HC658_23780 ENOG410644B Stage III sporulation protein af HC658_23800 ENOG4105KQ4 Stage iii sporulation protein ad HC658_23810 ENOG4108CQH stage III sporulation protein AC HC658_23820 ENOG4105KR5 Stage iii sporulation protein HC658_23830 ENOG4105CD2 stage iii sporulation protein aa HC658_23850 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HC658_23860 ENOG4105DC7 peptidase M24 HC658_23870 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HC658_23890 ENOG4105CBJ Metal-dependent enzyme HC658_23920 ENOG4105KST dependent repressor HC658_23930 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HC658_23940 ENOG4105WZW rhodanese family HC658_23950 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HC658_23960 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HC658_23970 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HC658_23980 ENOG4105C0D helicase HC658_24010 ENOG4108IMY Transcriptional regulator HC658_24030 ENOG4105VFR signal peptidase HC658_24150 ENOG41080XP Cbs domain HC658_24170 ENOG4105C37 (CBS) domain HC658_24220 ENOG4105C5X domain protein HC658_24270 ENOG4105E0M Sulfatase HC658_24300 ENOG4107ZXI Rhomboid family HC658_24320 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HC658_24370 ENOG41068DG YceG-like family HC658_24380 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HC658_24390 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HC658_24400 ENOG4105E2Z phosphate ABC transporter (Permease HC658_24410 ENOG4105C8U phosphate abc transporter HC658_24420 ENOG4105CVA phosphate HC658_24430 ENOG4107RF6 penicillin-binding protein HC658_24450 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HC658_24460 ENOG4105SXS Protein of unknown function (DUF456) HC658_24500 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HC658_24510 ENOG41063Y9 HC658_24520 ENOG4108U5J '-nucleotidase HC658_24530 ENOG4105N80 Ferric uptake regulator, Fur family HC658_24540 ENOG4108JYZ YitT family HC658_24550 ENOG41069ZM Protein of unknown function (DUF2624) HC658_24560 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HC658_24590 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HC658_24600 ENOG4105EGD dinuclear metal center protein, YbgI family HC658_24640 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC658_24650 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HC658_24660 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 HC658_24670 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HC658_24690 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HC658_24700 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HC658_24710 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HC658_24730 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HC658_24740 ENOG4105KG3 cytidine deaminase HC658_24750 ENOG4107YR5 Diacylglycerol kinase HC658_24760 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HC658_24770 ENOG4105CTJ Metal Dependent Phosphohydrolase HC658_24780 ENOG4105C9A Phoh family HC658_24790 ENOG4105EI1 sporulation protein yqfd HC658_24800 ENOG41068P3 sporulation protein YqfC HC658_24820 ENOG4105DI5 UPF0365 protein HC658_24830 ENOG4105F7J membrane-bound serine protease HC658_24840 ENOG4105KTH gatB Yqey HC658_24870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HC658_24880 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HC658_24890 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HC658_24920 ENOG4105CFG Acts as a chaperone (By similarity) HC658_24930 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HC658_24940 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HC658_24950 ENOG4105CSA Coproporphyrinogen iii oxidase HC658_24960 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HC658_24980 ENOG4108ZRV stage ii sporulation protein p HC658_24990 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HC658_25000 ENOG41082YS Binds directly to 16S ribosomal RNA HC658_25010 ENOG4105TQK DNA polymerase iii, delta' subunit HC658_25020 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HC658_25030 ENOG4108UK2 deaminase HC658_25040 ENOG4105KQC Competence protein HC658_25060 ENOG4108D32 Methyltransferase HC658_25080 ENOG4108WF2 Metal Dependent Phosphohydrolase HC658_25090 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HC658_25100 ENOG410812S Rna-binding protein HC658_25110 ENOG4105E2X shikimate dehydrogenase HC658_25120 ENOG4105CQW ribosome biogenesis GTPase YqeH HC658_25130 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HC658_25160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HC658_25170 ENOG41080BT SNARE associated Golgi HC658_25200 ENOG4105WFK nuclease HC658_25210 ENOG4107Y5K Resolvase HC658_25220 ENOG4108UXE Protein tyrosine phosphatase HC658_25230 ENOG4105D6J arsenicaL-resistance protein HC658_25240 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HC658_25250 ENOG41085FC arsR family transcriptional regulator HC658_25310 ENOG41064HX Suppressor of fused protein (SUFU) HC658_25340 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HC658_25390 ENOG410906S phage-like element pbsx protein xkdt HC658_25400 ENOG41066EA baseplate J family protein HC658_25410 ENOG4105MFU Protein of unknown function (DUF2634) HC658_25430 ENOG4105X7F HC658_25440 ENOG4108WZM domain protein HC658_25450 ENOG4108FKH Transglycosylase SLT domain HC658_25460 ENOG4105MTC XkdN-like protein HC658_25510 ENOG4105FR7 XkdM protein, phage-like element PBSX HC658_25520 ENOG4105PQS phage protein HC658_25550 ENOG41060SN HC658_25620 ENOG4106CGH Phage Mu protein F like protein HC658_25630 ENOG4108MDF Phage Portal Protein HC658_25640 ENOG4105IG6 Phage terminase, large subunit HC658_25680 ENOG4106129 HC658_25700 ENOG4105QBX endodeoxyribonuclease RusA HC658_25740 ENOG4108PNI recT protein HC658_25750 ENOG4108NF7 phage-type endonuclease HC658_25800 ENOG4106A7E Transcriptional regulator HC658_25810 ENOG41067QW Transcriptional regulator HC658_25820 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HC658_25840 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC658_25860 ENOG4108SWU Histidine kinase HC658_25870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HC658_25880 ENOG4105DHF Membrane HC658_25890 ENOG4108UYN gCN5-related N-acetyltransferase HC658_25900 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HC658_25910 ENOG41068VA HC658_25920 ENOG41087NI Sulfite exporter TauE/SafE HC658_25930 ENOG4105VFE sira family HC658_25940 ENOG4107TPS domain protein HC658_25960 ENOG4105VFE sira family HC658_25970 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HC658_25980 ENOG4105XTG Pfam:DUF156 HC658_25990 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein HC658_26000 ENOG41090E6 transcriptional regulator MERR family HC658_26030 ENOG4105C37 (CBS) domain HC658_26060 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HC658_26070 ENOG4105H3G oxidoreductase HC658_26080 ENOG4105PGM cation diffusion facilitator family transporter HC658_26090 ENOG41090U3 tautomerase HC658_26130 ENOG4105KMT branched-chain amino acid HC658_26140 ENOG4108UMN azlc family HC658_26150 ENOG4108ZRZ Transcriptional regulator (AsnC family) HC658_26160 ENOG41067XF inhibitor HC658_26200 ENOG41064BW Protein of unknown function (DUF2568) HC658_26220 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HC658_26230 ENOG4105EA8 2-Nitropropane dioxygenase HC658_26240 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HC658_26270 ENOG4108MEK Metal-binding protein YodA HC658_26280 ENOG410904A RNA polymerase HC658_26290 ENOG4105CPC Aldo Keto reductase HC658_26310 ENOG4108KAM Transcriptional regulator HC658_26320 ENOG4105C7F AcnD-accessory protein PrpF HC658_26330 ENOG41083Q9 chitosanase HC658_26340 ENOG4105X5K response regulator receiver protein HC658_26350 ENOG4108VQT Alpha beta hydrolase fold protein HC658_26360 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HC658_26370 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HC658_26380 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase HC658_26400 ENOG4105PGS Spore coat protein HC658_26410 ENOG4105E2A Dehydrogenase HC658_26440 ENOG4105VUF Transcriptional regulator HC658_26460 ENOG4105DQ4 alcohol dehydrogenase HC658_26470 ENOG4108Z0Z intracellular protease Pfpi family HC658_26480 ENOG4108HKT sucrose-6-phosphate hydrolase HC658_26490 ENOG4105F3R pts system mannose fructose sorbose family iid HC658_26500 ENOG4105ETZ PTS System HC658_26510 ENOG4108IQ3 PTS system HC658_26520 ENOG4105YHU PTS system HC658_26530 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HC658_26540 ENOG4105C85 amino acid HC658_26550 ENOG4105N14 lysine exporter protein LysE YggA HC658_26560 ENOG4108NGU Transcriptional regulator HC658_26570 ENOG4105JVQ RNA Polymerase HC658_26580 ENOG4108P49 AntiSigma factor HC658_26590 ENOG4105EXC Acyl-transferase HC658_26600 ENOG4105WDR HC658_26610 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HC658_26620 ENOG41082JN Transcriptional regulator HC658_26660 ENOG4105TMB Formate nitrite transporter HC658_26670 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HC658_26680 ENOG4108JB9 formate dehydrogenase HC658_26710 ENOG4105C28 cystathionine HC658_26740 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HC658_26770 ENOG4107XRG penicillin-binding protein HC658_26780 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HC658_26790 ENOG4105DBI uridine monophosphokinase HC658_26800 ENOG4105CFP Peptidase U32 HC658_26810 ENOG4105XYU peptidase (U32 family) HC658_26830 ENOG4105HHA aminodeoxychorismate lyase HC658_26840 ENOG4105VPH UPF0473 protein HC658_26850 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HC658_26860 ENOG4105VBH UPF0297 protein HC658_26870 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HC658_26880 ENOG4105C02 permease HC658_26890 ENOG4105CDA abc transporter atp-binding protein HC658_26900 ENOG4105CT1 (ABC) transporter HC658_26910 ENOG4105EAD ABC transporter HC658_26920 ENOG4105DRP amino acid AbC transporter HC658_26940 ENOG41060CR HC658_26960 ENOG4105C7H Helicase, RecD TraA family HC658_26980 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HC658_26990 ENOG4105C3J Cysteine desulfurase HC658_27010 ENOG4105D1H recombination factor protein RarA HC658_27020 ENOG4105CUZ uba thif-type nad fad binding protein HC658_27050 ENOG4105C9M aspartyl-trna synthetase HC658_27060 ENOG4105CUT histidyl-tRNA synthetase HC658_27080 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC658_27100 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HC658_27110 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HC658_27120 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HC658_27130 ENOG41067VP Protein of unknown function (DUF1049) HC658_27140 ENOG4105NCW Trka-c domain protein HC658_27150 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HC658_27170 ENOG4105CKP Polysaccharide Biosynthesis Protein HC658_27180 ENOG4108QG2 Membrane HC658_27190 ENOG4105NAP HC658_27200 ENOG4105VIE preprotein translocase, subunit YajC HC658_27210 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HC658_27220 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HC658_27230 ENOG41061AI Protein of unknown function (DUF2905) HC658_27240 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HC658_27250 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HC658_27270 ENOG4105IE8 Alpha-ketoglutarate permease HC658_27280 ENOG4105CK5 oxidoreductase HC658_27320 ENOG4105BZG amino acid carrier protein HC658_27330 ENOG4105CDY transcriptional regulatory protein HC658_27350 ENOG4106678 morphogenetic protein associated with SpoVID HC658_27360 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HC658_27370 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HC658_27380 ENOG4108IYU L-aspartate oxidase HC658_27410 ENOG4105CQC Prephenate dehydratase HC658_27420 ENOG41090I5 UPF0735 ACT domain-containing protein HC658_27430 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HC658_27450 ENOG4105K46 50S ribosomal protein l27 HC658_27460 ENOG4105X36 (ribosomal) protein HC658_27470 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HC658_27500 ENOG4107QMS site-determining protein HC658_27510 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HC658_27520 ENOG4105YHC Rod shape-determining protein MreD HC658_27540 ENOG4105DFF Rod shape-determining protein mreb HC658_27550 ENOG4105W5Q DNA repair protein (RadC HC658_27560 ENOG4108Z03 MAF-like protein HC658_27580 ENOG4106A3R peptidase HC658_27590 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HC658_27600 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HC658_27620 ENOG4106AR7 Spore coat protein HC658_27630 ENOG41068KH stage VI sporulation protein D HC658_27640 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HC658_27650 ENOG4105D52 delta-aminolevulinic acid dehydratase HC658_27670 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HC658_27690 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HC658_27710 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HC658_27720 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HC658_27730 ENOG4108IUQ atp-dependent protease HC658_27740 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HC658_27750 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HC658_27770 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HC658_27780 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HC658_27790 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HC658_27800 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HC658_27810 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HC658_27820 ENOG4108ZP8 Acetolactate synthase small subunit HC658_27830 ENOG4105C7K acetolactate synthase HC658_27850 ENOG4105I4A GCN5-related N-acetyltransferase HC658_27870 ENOG4107KM7 Heat induced stress protein YflT HC658_27890 ENOG4105M59 Phosphodiesterase, mj0936 family HC658_27900 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HC658_27910 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HC658_27920 ENOG4108XJQ germination protein HC658_27930 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HC658_27940 ENOG41067TZ transcriptional regulator, MarR family HC658_27950 ENOG4105PFC Transcriptional regulator HC658_27970 ENOG4105E33 succinate dehydrogenase HC658_27990 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HC658_28010 ENOG4105CFH Aspartokinase HC658_28020 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HC658_28030 ENOG4105K63 Thioredoxin HC658_28050 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HC658_28060 ENOG4105C10 Electron transfer flavoprotein HC658_28070 ENOG4105BZJ Electron transfer flavoprotein HC658_28080 ENOG41060WC Enoyl-CoA hydratase HC658_28090 ENOG4107Z3H Transcriptional regulator, TetR family HC658_28100 ENOG4105CEY Amp-dependent synthetase and ligase HC658_28120 ENOG4105C98 muts2 protein HC658_28130 ENOG4105DCG PHP domain protein HC658_28160 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HC658_28170 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HC658_28180 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HC658_28190 ENOG4108RWN rrna methyltransferase HC658_28200 ENOG41067MF small acid-soluble spore protein HC658_28220 ENOG4105CQB FAD linked oxidase domain protein HC658_28230 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HC658_28260 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HC658_28270 ENOG4105DRS transport system, permease HC658_28300 ENOG4108MDK Dehydrogenase HC658_28320 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HC658_28330 ENOG4105EF1 ribulokinase HC658_28350 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HC658_28360 ENOG4105CN9 Peptidase m42 family protein HC658_28380 ENOG410696E Membrane HC658_28390 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HC658_28400 ENOG4105VJV 50s ribosomal protein L35 HC658_28410 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HC658_28430 ENOG41067MG lrgb family HC658_28450 ENOG4105DY9 regulatoR HC658_28460 ENOG4108HRK Histidine kinase HC658_28480 ENOG4105C22 threonyL-tRNA synthetase HC658_28490 ENOG4108TDW sporulation protein YtxC HC658_28530 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HC658_28540 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HC658_28550 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HC658_28560 ENOG4105KVH Transcriptional regulator HC658_28570 ENOG4105F27 Major Facilitator HC658_28580 ENOG4105CV8 reductase HC658_28590 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HC658_28610 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HC658_28620 ENOG4105C2M dna polymerase I HC658_28630 ENOG4105BZU Histidine kinase HC658_28640 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HC658_28650 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HC658_28660 ENOG4108HMX isocitrate dehydrogenase (NADP) HC658_28670 ENOG4105BZN citrate synthase HC658_28690 ENOG4108REF Sporulation integral membrane protein ytvi HC658_28700 ENOG4105FS0 cytoplasmic membrane protein HC658_28710 ENOG4105CA9 Pyruvate kinase HC658_28720 ENOG4105CTQ phosphohexokinase HC658_28740 ENOG4108IEY Carboxyl transferase domain HC658_28750 ENOG4105C6K Malic enzyme HC658_28760 ENOG4105C0B DNA polymerase III (alpha subunit) HC658_28770 ENOG4105VV2 HC658_28790 ENOG4106EVM HC658_28800 ENOG4105SFS phosphoesterase RecJ domain protein HC658_28830 ENOG410635A Membrane HC658_28840 ENOG4105CH2 amidohydrolase HC658_28880 ENOG4105DEN Luciferase family HC658_28890 ENOG4105CDA abc transporter atp-binding protein HC658_28940 ENOG4108XSB acetyltransferase, (GNAT) family HC658_28950 ENOG4108KSA LysR family transcriptional regulator HC658_28960 ENOG4105E8R UPF0173 metal-dependent hydrolase HC658_28990 ENOG4105CH7 arginosuccinase HC658_29000 ENOG4105CDH Citrulline--aspartate ligase HC658_29010 ENOG4105EPU Molybdenum cofactor synthesis domain protein HC658_29020 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HC658_29040 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HC658_29050 ENOG4105KBJ sporulation protein ytfj HC658_29070 ENOG4105VK3 rdd domain containing protein HC658_29080 ENOG4105D07 Signal peptide peptidase, SppA HC658_29090 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HC658_29100 ENOG4105EFZ amidohydrolase HC658_29110 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HC658_29180 ENOG4105U5Y Transcriptional regulator HC658_29200 ENOG4105BZU Histidine kinase HC658_29220 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HC658_29230 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HC658_29250 ENOG4105F1V Acetoin utilization protein HC658_29260 ENOG4105W87 Cbs domain HC658_29270 ENOG4105DGU Histone deacetylase HC658_29280 ENOG4105ER2 Ompa motb domain protein HC658_29290 ENOG4107R0U MotA TolQ exbB proton channel HC658_29300 ENOG4105ETE Transcriptional regulator (LacI family HC658_29310 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HC658_29350 ENOG4105DFU Cell wall formation (By similarity) HC658_29370 ENOG4108VDD TRNA binding domain protein HC658_29400 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HC658_29430 ENOG4105C6K Malic enzyme HC658_29440 ENOG4105C8F Beta-lactamase domain protein HC658_29450 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HC658_29470 ENOG4108V15 phosphotransferase enzyme family HC658_29480 ENOG4108IUM Glycogen debranching enzyme HC658_29510 ENOG4107F58 2'-5' rna ligase HC658_29520 ENOG4105C6T cysteine synthase HC658_29530 ENOG4107QSE Dipeptidase HC658_29540 ENOG4105C7N Xanthine uracil vitamin C permease HC658_29570 ENOG4105YW5 deoR family transcriptional regulator HC658_29600 ENOG4105CBX hi0933 family HC658_29610 ENOG4105C94 Transporter HC658_29630 ENOG4105MU9 integral membrane protein HC658_29640 ENOG4105DDC Oxidoreductase domain protein HC658_29660 ENOG4105F5H Glycosyl Hydrolase Family 88 HC658_29680 ENOG41075H3 AraC family transcriptional regulator HC658_29700 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HC658_29720 ENOG4106A3M Cytochrome p-450 HC658_29730 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HC658_29750 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HC658_29760 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HC658_29780 ENOG4105NTD Inherit from COG: Hydrolase HC658_29840 ENOG41085GJ domain protein HC658_29850 ENOG4105C8T Leucyl-tRNA synthetase HC658_29870 ENOG4105BZU Histidine kinase HC658_29880 ENOG410605W Major Facilitator HC658_29890 ENOG4106UBQ HC658_29910 ENOG4105C19 ABC transporter HC658_29920 ENOG4105EWM Histidine kinase HC658_29940 ENOG4107R34 abc transporter permease protein HC658_29950 ENOG4105C19 ABC transporter HC658_29980 ENOG4105DVE abc transporter atp-binding protein HC658_29990 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HC658_30010 ENOG4105N5T Radical SAM Protein HC658_30040 ENOG4105E8V Alpha Beta Hydrolase Fold protein HC658_30050 ENOG4108Z0R Transferase HC658_30060 ENOG4105C85 amino acid HC658_30070 ENOG4105CAQ asparagine synthetase HC658_30080 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HC658_30090 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HC658_30120 ENOG4105D2X ABC transporter substrate-binding protein HC658_30140 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HC658_30170 ENOG4108RMU ferritin dps family protein HC658_30190 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HC658_30200 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HC658_30210 ENOG4108V2W Carbonate dehydratase HC658_30260 ENOG4105CC5 ABC transporter HC658_30270 ENOG4105CC5 ABC transporter HC658_30280 ENOG4105DIK (ABC) transporter HC658_30290 ENOG4105DSE periplasmic solute binding protein HC658_30300 ENOG4105DTQ mandelate racemase muconate lactonizing HC658_30310 ENOG4105CEY Amp-dependent synthetase and ligase HC658_30320 ENOG4108IPT Naphthoate synthase HC658_30330 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HC658_30340 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HC658_30350 ENOG4105E4F Isochorismate synthase HC658_30390 ENOG4108IAJ Nad-dependent epimerase dehydratase HC658_30400 ENOG4107SBE Glycosyl transferase (Group 1 HC658_30430 ENOG4107SBE Glycosyl transferase (Group 1 HC658_30440 ENOG4108KS4 Spore coat protein HC658_30470 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HC658_30490 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HC658_30750 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HC658_30760 ENOG4105VRR gCN5-related N-acetyltransferase HC658_30770 ENOG4105DZ6 Band 7 protein HC658_30790 ENOG4106DF1 HC658_30800 ENOG4108VNY MOSC domain protein HC658_30810 ENOG4108JB8 alcohol dehydrogenase HC658_30830 ENOG4105TRT Transcriptional regulator HC658_30860 ENOG4105CZN Potassium uptake protein HC658_30870 ENOG4107I77 yiaA/B two helix domain HC658_30880 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HC658_30920 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HC658_30940 ENOG4105EE0 oxidoreductase HC658_30950 ENOG4105DKG l-rhamnose isomerase HC658_30960 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HC658_30970 ENOG4105DET Rhamnulokinase HC658_30980 ENOG4105E98 transcriptional regulator DeoR family HC658_31000 ENOG4105C8Q Methyl-accepting chemotaxis HC658_31010 ENOG4105C8Q Methyl-accepting chemotaxis HC658_31020 ENOG4105C8Q Methyl-accepting chemotaxis HC658_31030 ENOG4105C8Q Methyl-accepting chemotaxis HC658_31060 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HC658_31080 ENOG4105C37 (CBS) domain HC658_31110 ENOG4107PBV potassium channel HC658_31120 ENOG4107PBV potassium channel HC658_31150 ENOG4107QYV phosphohexose isomerase HC658_31170 ENOG4107QW4 alcohol dehydrogenase HC658_31180 ENOG4105WG9 Conserved Protein HC658_31210 ENOG4105CHM Aminotransferase HC658_31220 ENOG4108ZB6 transcriptional regulator AsnC family HC658_31230 ENOG4108MUZ hydrolase HC658_31250 ENOG4105C87 Aminotransferase class I and II HC658_31260 ENOG4108HGU Histidine kinase HC658_31270 ENOG4105Y38 Kinase-associated protein B HC658_31310 ENOG4105BZ4 penicillin-binding protein HC658_31320 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HC658_31350 ENOG4108MRH transcriptional regulatory protein HC658_31360 ENOG4105DIH basic membrane HC658_31370 ENOG4108JQ9 ABC transporter HC658_31380 ENOG4105UIB (ABC) transporter HC658_31420 ENOG4105D65 subunit l HC658_31430 ENOG4105HC0 Na H antiporter HC658_31440 ENOG4108ZE9 Monovalent cation H antiporter subunit C HC658_31450 ENOG4108JPZ Monovalent cation H antiporter subunit D HC658_31460 ENOG4105SC1 monovalent cation H antiporter subunit E HC658_31480 ENOG4105KJM monovalent cation h antiporter subunit g HC658_31490 ENOG4105KA0 thioesterase Superfamily protein HC658_31510 ENOG4105BZU Histidine kinase HC658_31560 ENOG4105D58 Diguanylate phosphodiesterase HC658_31570 ENOG4105DAP Nicotinate phosphoribosyltransferase HC658_31620 ENOG4105C02 permease HC658_31660 ENOG410904N short-chain dehydrogenase reductase HC658_31740 ENOG4108K8K Transcriptional regulator HC658_31750 ENOG4105DCF alanine dehydrogenase HC658_31770 ENOG4105WQT MbtH domain protein HC658_31780 ENOG4105CEY Amp-dependent synthetase and ligase HC658_31790 ENOG4105WQI isochorismatase HC658_31800 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HC658_31810 ENOG4105E4F Isochorismate synthase HC658_31820 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HC658_31830 ENOG4105NIV Esterase HC658_31870 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HC658_31890 ENOG41069ER domain protein HC658_31920 ENOG4105CEP NADH dehydrogenase HC658_31930 ENOG4105CAY ferredoxin--nadp reductase HC658_31970 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HC658_31980 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HC658_32010 ENOG4105ZKE UPF0349 protein HC658_32040 ENOG41083MR nifu domain-containing protein HC658_32050 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HC658_32060 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HC658_32070 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HC658_32080 ENOG4105D6E homoserine dehydrogenase HC658_32100 ENOG4108W5N phosphatidylglycerophosphatase a HC658_32110 ENOG4105D4U had-superfamily hydrolase, subfamily iia HC658_32130 ENOG4105MMD transcriptional regulator HC658_32140 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HC658_32150 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HC658_32160 ENOG4105FAA peptidase M23 HC658_32170 ENOG4108YTE sporulation protein YunB HC658_32180 ENOG4105KZD Domain of unknown function (DUF1805) HC658_32190 ENOG4107R8B 5'-nucleotidase HC658_32210 ENOG4105I3N Conserved Protein HC658_32230 ENOG4105CD3 dihydroorotase HC658_32240 ENOG4105G9B Transcriptional regulator HC658_32270 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HC658_32280 ENOG4105VT2 5-hydroxyisourate hydrolase HC658_32300 ENOG4107YV9 domain protein HC658_32310 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HC658_32340 ENOG4105XRQ Xanthine dehydrogenase accessory factor HC658_32350 ENOG4105C5R Aminotransferase HC658_32370 ENOG4108K8S endonuclease I HC658_32380 ENOG4108IJ9 (ABC) transporter HC658_32390 ENOG4105FDP GntR family transcriptional regulator HC658_32400 ENOG4108KPW sugar kinase HC658_32410 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HC658_32420 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HC658_32430 ENOG4105XN3 extracellular solute-binding protein family 1 HC658_32440 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HC658_32450 ENOG4105PKS Excinuclease abc c subunit domain protein HC658_32460 ENOG4107VFR oxidoreductase HC658_32480 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HC658_32490 ENOG4105DIW FeS assembly protein SUFB HC658_32500 ENOG4108UNV SUF system FeS assembly protein, NifU family HC658_32510 ENOG4105C9B Cysteine desulfurase HC658_32520 ENOG4105JRK feS assembly protein SufD HC658_32530 ENOG4105C3K feS assembly ATPase SufC HC658_32560 ENOG4105D01 (LipO)protein HC658_32570 ENOG4108UMI ABC transporter, permease HC658_32580 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HC658_32630 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HC658_32640 ENOG41080E8 Transcriptional regulator, Spx MgsR family HC658_32650 ENOG4105C1G acyl-Coa dehydrogenase HC658_32660 ENOG4105CHU acetyl-coa acetyltransferase HC658_32720 ENOG41067TZ transcriptional regulator, MarR family HC658_32730 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC658_32740 ENOG4105MDS 4-oxalocrotonate tautomerase HC658_32760 ENOG4105EGI Transcriptional regulator HC658_32780 ENOG4105E0A ABC, transporter HC658_32810 ENOG4105E1F short-chain dehydrogenase reductase HC658_32820 ENOG4105HUF DNA protection during starvation protein HC658_32830 ENOG4105C0H protease HC658_32850 ENOG4105F3H Histidine kinase HC658_32870 ENOG41067SE Tetr family transcriptional regulator HC658_32880 ENOG4105C9Q fumarate hydratase class II HC658_32930 ENOG4105WH1 Two component transcriptional regulator luxr family HC658_32940 ENOG4105ENE Histidine kinase HC658_32970 ENOG41087YS Phage shock protein A HC658_33000 ENOG4108WBT adenosyltransferase HC658_33010 ENOG4105E0A ABC, transporter HC658_33020 ENOG4105EHG Permease protein HC658_33030 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HC658_33040 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HC658_33050 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HC658_33070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HC658_33090 ENOG4106DF4 Sigma-70, region 4 HC658_33110 ENOG4105F0F Oxalate decarboxylase HC658_33130 ENOG4107RBB ABC transporter, permease HC658_33140 ENOG4105C19 ABC transporter HC658_33150 ENOG4108WMK Efflux transporter RND family MFP subunit HC658_33160 ENOG4105E0A ABC, transporter HC658_33170 ENOG4105EHG Permease protein HC658_33180 ENOG4105DQ5 transport system permease protein HC658_33210 ENOG4105D5Q Arginine ornithine antiporter HC658_33230 ENOG4107K5X Membrane-bound metal-dependent hydrolase HC658_33240 ENOG4107QZ2 Sulfatase HC658_33250 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HC658_33260 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HC658_33270 ENOG4105E0C molybdate abc transporter HC658_33300 ENOG4105EEQ Na H antiporter HC658_33310 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HC658_33320 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HC658_33330 ENOG4105EEM helicase HC658_33350 ENOG4105EN6 Membrane HC658_33370 ENOG4107ZQN disulfide bond HC658_33380 ENOG4105C59 p-type ATPase HC658_33390 ENOG4105C59 p-type ATPase HC658_33400 ENOG410681U heavy metal transport detoxification protein HC658_33410 ENOG4105VPX protein, conserved in bacteria HC658_33420 ENOG4105D9R oxidoreductase HC658_33430 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HC658_33440 ENOG4105ME7 Membrane HC658_33450 ENOG4105RXJ HC658_33460 ENOG4105KPY Small multidrug resistance protein HC658_33470 ENOG4105KBX Transcriptional regulator, TetR family HC658_33480 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HC658_33490 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HC658_33500 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HC658_33520 ENOG4105XZU Preprotein translocase, subunit SecG HC658_33560 ENOG4105KVH Transcriptional regulator HC658_33570 ENOG4105C8Q Methyl-accepting chemotaxis HC658_33580 ENOG4105R40 Glycine betaine carnitine choline HC658_33590 ENOG4108HQR Glycine betaine HC658_33600 ENOG4105E90 ABC transporter HC658_33610 ENOG4108IJ8 ABC transporter HC658_33620 ENOG4107HG4 Transcriptional regulator HC658_33630 ENOG4105H5S HC658_33660 ENOG41082BM Transcriptional regulator, arsr family HC658_33670 ENOG4105R40 Glycine betaine carnitine choline HC658_33680 ENOG4108HQR Glycine betaine HC658_33690 ENOG4105E90 ABC transporter HC658_33700 ENOG4108IJ8 ABC transporter HC658_33710 ENOG4107HG4 Transcriptional regulator HC658_33720 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HC658_33730 ENOG4108QCI YvbH-like oligomerisation region HC658_33750 ENOG4105T65 Membrane-associated protein HC658_33760 ENOG4108W0I acetyltransferase HC658_33770 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HC658_33780 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HC658_33790 ENOG4105CP7 Triose-phosphate isomerase HC658_33800 ENOG4105BZA Phosphoglycerate kinase HC658_33810 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HC658_33840 ENOG4105CMD Transcriptional regulator, GntR family HC658_33850 ENOG4105DEN Luciferase family HC658_33860 ENOG4105GZI Transcriptional regulator HC658_33870 ENOG4107RT3 EamA-like transporter family HC658_33890 ENOG4105VRS hydrolase family 18 HC658_33900 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HC658_33910 ENOG4107QR9 Iron-sulfur cluster binding protein HC658_33920 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HC658_33940 ENOG4105BZU Histidine kinase HC658_33950 ENOG4105KCT ABC transporter HC658_33960 ENOG4108M15 ABC transporter HC658_33970 ENOG4107R6F Alpha Beta Hydrolase Fold protein HC658_33980 ENOG4108MJI response regulator HC658_34010 ENOG4105EG2 ABC transporter, permease HC658_34030 ENOG4107FKK extracellular solute-binding protein family 1 HC658_34050 ENOG4105JXH GntR family transcriptional regulator HC658_34060 ENOG4105DAA L-lactate HC658_34070 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC658_34090 ENOG4108ZPC Polysaccharide pyruvyl transferase HC658_34100 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HC658_34110 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HC658_34120 ENOG4105D3Q Sugar transferase HC658_34140 ENOG4105K64 Glycosyl transferase, family 2 HC658_34160 ENOG4107QRS glycosyltransferase group 2 family protein HC658_34170 ENOG41068W6 Capsular polysaccharide biosynthesis protein HC658_34180 ENOG4108KMV Glycosyl transferase (Group 1 HC658_34190 ENOG4105K64 Glycosyl transferase, family 2 HC658_34200 ENOG4108PQP glycosyl transferase group 1 HC658_34220 ENOG4108QV3 biosynthesis protein HC658_34230 ENOG4105HTX biosynthesis protein HC658_34250 ENOG4105EBR Carboxylesterase HC658_34270 ENOG4105PY6 Phenolic acid decarboxylase HC658_34280 ENOG4105NI3 Protein of unknown function (DUF3237) HC658_34300 ENOG4105FQP Beta-lactamase HC658_34310 ENOG4105EDQ levansucrase EC 2.4.1.10 HC658_34320 ENOG4108HKT sucrose-6-phosphate hydrolase HC658_34330 ENOG4107QTZ amino acid HC658_34380 ENOG4105DNP FAD linked oxidase domain protein HC658_34390 ENOG4105IRW patatin-like phospholipase family protein HC658_34410 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HC658_34420 ENOG4107URF beta-phospho-glucomutase HC658_34430 ENOG4105CG3 alpha amylase, catalytic region HC658_34460 ENOG4105EG2 ABC transporter, permease HC658_34470 ENOG4105D56 permease protein HC658_34480 ENOG4107FKK extracellular solute-binding protein family 1 HC658_34490 ENOG4108IUK alpha amylase, catalytic HC658_34500 ENOG4105FKQ transcriptional regulator HC658_34510 ENOG4108URH decarboxylase HC658_34520 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HC658_34530 ENOG4105CHH sulfate transporter HC658_34540 ENOG4108V2W Carbonate dehydratase HC658_34550 ENOG4105C5I Dehydrogenase HC658_34570 ENOG4105C19 ABC transporter HC658_34580 ENOG4105EWM Histidine kinase HC658_34600 ENOG4107A6P HC658_34610 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HC658_34620 ENOG4105KRI phosphocarrier protein (HPr HC658_34630 ENOG4105CIE May be required for sporulation (By similarity) HC658_34640 ENOG4105CHW UPF0052 protein HC658_34650 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HC658_34660 ENOG4108Z4K mutator MutT protein HC658_34670 ENOG4105C3M thioredoxin reductase HC658_34700 ENOG4105BZ1 (ABC) transporter HC658_34720 ENOG4106FGC HC658_34740 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HC658_34750 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HC658_34760 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HC658_34770 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HC658_34780 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HC658_34790 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HC658_34800 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HC658_34810 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HC658_34830 ENOG4108E16 pectate lyase HC658_34840 ENOG4108S4C acetyltransferase HC658_34850 ENOG4107XGZ Hydrolase HC658_34860 ENOG4105HKU nucleoside recognition domain-containing protein HC658_34870 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HC658_34880 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HC658_34890 ENOG4105CE4 GlcNAc 6-P deacetylase HC658_34900 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HC658_34920 ENOG41088CQ domain protein HC658_34940 ENOG4106A3M Cytochrome p-450 HC658_34950 ENOG410625E HC658_34980 ENOG41086DT Membrane protein of unknown function HC658_34990 ENOG41067S9 phage shock protein C, PspC HC658_35000 ENOG4108PY7 HC658_35040 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HC658_35050 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HC658_35080 ENOG4105MKU Transcriptional regulator HC658_35120 ENOG4105CN1 protease HC658_35130 ENOG4105CRP Part of the ABC transporter FtsEX involved in HC658_35140 ENOG4105CAK Cell division ATP-binding protein ftsE HC658_35170 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HC658_35190 ENOG4105MS2 ribosomal subunit Interface protein HC658_35220 ENOG4105MQ3 flagellar protein FliS HC658_35230 ENOG4107RT6 flagellar hook-associated HC658_35240 ENOG41083S7 flagellar protein FlaG HC658_35250 ENOG4105I03 Flagellin HC658_35260 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HC658_35270 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HC658_35280 ENOG4105MKD HC658_35290 ENOG4105DTJ flagellar hook-associated protein HC658_35300 ENOG4105E1Q flagellar hook-associated protein HC658_35330 ENOG4105RU3 HC658_35340 ENOG41081UC Inherit from COG: Competence protein HC658_35380 ENOG4105WH1 Two component transcriptional regulator luxr family HC658_35390 ENOG4105BZU Histidine kinase HC658_35400 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HC658_35410 ENOG4108KGH TRANSCRIPTIONal HC658_35420 ENOG4105ESV Glycosyl transferase, family 4 HC658_35430 ENOG4107EF8 Glycosyl transferase (Group 1 HC658_35460 ENOG4105QZI O-Antigen Polymerase HC658_35470 ENOG4105C6Y Udp-glucose 6-dehydrogenase HC658_35480 ENOG4107RA4 Glycosyl transferase (Group 1 HC658_35490 ENOG4105PSV Polysaccharide Biosynthesis Protein HC658_35500 ENOG4105D3Q Sugar transferase HC658_35510 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC658_35520 ENOG4105JFG SpoIID LytB domain protein HC658_35550 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HC658_35560 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HC658_35580 ENOG4107VDP teichoic acid biosynthesis HC658_35590 ENOG41088M2 Glycosyl transferase family 2 HC658_35610 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HC658_35620 ENOG4105EY8 ABC transporter HC658_35640 ENOG4107SJB teichoic acid biosynthesis HC658_35650 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HC658_35660 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HC658_35680 ENOG4107RZX Teichoic acid biosynthesis protein HC658_35690 ENOG410651K Teichoic acid biosynthesis protein C HC658_35710 ENOG4105DG6 mannose-6-phosphate isomerase HC658_35740 ENOG4108NHD germination protein HC658_35750 ENOG4105C54 Major Facilitator superfamily HC658_35760 ENOG4108KGH TRANSCRIPTIONal HC658_35770 ENOG4105J7I hydrolase HC658_35780 ENOG4105K4H Nlp p60 protein HC658_35800 ENOG4105PNM synthesis protein HC658_35820 ENOG4105N98 Capsule biosynthesis protein capB HC658_35830 ENOG4105ETE Transcriptional regulator (LacI family HC658_35840 ENOG4108RVA ribokinase HC658_35850 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HC658_35860 ENOG4105C2J ABC transporter HC658_35870 ENOG4105CNN ABC, transporter HC658_35880 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HC658_35910 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HC658_35920 ENOG4107FQX Alpha-acetolactate decarboxylase HC658_35940 ENOG4107RSM transcriptional regulator HC658_35970 ENOG4106UIA HC658_36000 ENOG4107XC4 flavin reductase domain protein, FMN-binding HC658_36020 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HC658_36040 ENOG4105CAH Chromate HC658_36050 ENOG4105FGV Chromate HC658_36070 ENOG4108WS4 fmn reductase HC658_36080 ENOG4107V2S Transcriptional regulator HC658_36090 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HC658_36140 ENOG4108XI2 Domain of unknown function (DUF1963) HC658_36150 ENOG4105C6Y Udp-glucose 6-dehydrogenase HC658_36160 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HC658_36170 ENOG4107YJ4 chain length determinant protein HC658_36180 ENOG4105HTX biosynthesis protein HC658_36200 ENOG4105KBK Zinc finger, swim domain protein HC658_36210 ENOG4105C0D helicase HC658_36220 ENOG410667J hydrolase HC658_36230 ENOG4105E98 transcriptional regulator DeoR family HC658_36240 ENOG4105Z8H single-stranded DNA-binding protein HC658_36300 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HC658_36310 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HC658_36330 ENOG4105CGA flagellar basal-body rod protein FlgG HC658_36350 ENOG4105DFF Rod shape-determining protein mreb HC658_36360 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HC658_36370 ENOG4107MII Sugar-specific transcriptional regulator TrmB HC658_36380 ENOG4105CZM Major Facilitator HC658_36390 ENOG4108M26 parallel beta-helix repeat protein HC658_36400 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HC658_36410 ENOG41080V3 Major Facilitator superfamily HC658_36420 ENOG4105D3W isochorismatase HC658_36430 ENOG4107P26 HC658_36440 ENOG4105BZU Histidine kinase HC658_36460 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HC658_36480 ENOG4105FRN stage II sporulation protein HC658_36490 ENOG4107TCE N-acetyltransferase HC658_36520 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HC658_36530 ENOG4107TXC Transcriptional regulator HC658_36540 ENOG4106BRK HC658_36550 ENOG4108RYK Nad-dependent epimerase dehydratase HC658_36560 ENOG4108Z40 Transcriptional regulator HC658_36570 ENOG4105CQM Urea amidohydrolase subunit alpha HC658_36580 ENOG4105KI2 Urea amidohydrolase subunit beta HC658_36590 ENOG4108YZ9 Urea amidohydrolase subunit gamma HC658_36660 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HC658_36680 ENOG4108TF4 von Willebrand factor, type A HC658_36700 ENOG4105JFG SpoIID LytB domain protein HC658_36710 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HC658_36730 ENOG4106778 Protein of unknown function (DUF1146) HC658_36750 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HC658_36760 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HC658_36770 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HC658_36780 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HC658_36820 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) HC658_36840 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HC658_36850 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HC658_36860 ENOG4108UIC UPF0340 protein HC658_36870 ENOG4108YZG isomerase HC658_36880 ENOG4107WAU Protein tyrosine phosphatase HC658_36890 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HC658_36900 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HC658_36920 ENOG4108ZXQ stage ii sporulation protein r HC658_36950 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HC658_36960 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HC658_36970 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HC658_36990 ENOG4107TT2 Auxin Efflux Carrier HC658_37000 ENOG4105C6K Malic enzyme HC658_37010 ENOG4107104 thymidine kinase HC658_37030 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HC658_37050 ENOG4105CBT Fructose-1,6-bisphosphatase HC658_37060 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HC658_37070 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway HC658_37080 ENOG4105D2N Aldolase HC658_37090 ENOG410812K response regulator receiver protein HC658_37110 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HC658_37130 ENOG4105C1G acyl-Coa dehydrogenase HC658_37140 ENOG4105DF6 Fe-S oxidoreductase HC658_37160 ENOG4105E5J UV damage endonuclease HC658_37180 ENOG4105NAE bifunctional deaminase-reductase domain protein HC658_37190 ENOG4105BZ1 (ABC) transporter HC658_37200 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HC658_37220 ENOG4105R3A Nitrate reductase HC658_37230 ENOG4108IUE nitrate reductase beta subunit HC658_37270 ENOG4107V6Q Cyclic nucleotide-binding domain HC658_37290 ENOG4105C75 arginyL-tRNA synthetase HC658_37300 ENOG410684U Domain of unknown function (DUF1934) HC658_37320 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HC658_37410 ENOG4107JM4 Tetratricopeptide repeat HC658_37430 ENOG4105CYW agmatinase HC658_37440 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HC658_37450 ENOG4105BZ4 penicillin-binding protein HC658_37460 ENOG4108XFG YwhD family HC658_37470 ENOG4108Z4T Peptidase M50 HC658_37480 ENOG41069HH 4-oxalocrotonate tautomerase HC658_37490 ENOG41067TZ transcriptional regulator, MarR family HC658_37500 ENOG4105C22 threonyL-tRNA synthetase HC658_37520 ENOG4105C57 major facilitator superfamily HC658_37530 ENOG41062ES Transcriptional regulator HC658_37550 ENOG4105DCI Phosphohydrolase HC658_37570 ENOG4108VCI transcription factor, rsfa family HC658_37580 ENOG4108RNG Permease of the drug metabolite transporter HC658_37600 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HC658_37610 ENOG4105DUM transcriptional regulator, lysR family HC658_37620 ENOG4108IJ2 phosphate acetyltransferase HC658_37650 ENOG4105CHM Aminotransferase HC658_37670 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase HC658_37680 ENOG4105CHR reductase HC658_37690 ENOG4106CHD Bacilysin biosynthesis protein bacB HC658_37700 ENOG41061WN bacilysin biosynthesis protein HC658_37710 ENOG4105FCW Major Facilitator superfamily HC658_37740 ENOG4105C26 Dehydrogenase HC658_37750 ENOG4105D82 Glutamate dehydrogenase HC658_37770 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HC658_37780 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HC658_37790 ENOG4105C1B dTDP-glucose 4-6-dehydratase HC658_37800 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HC658_37810 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG HC658_37820 ENOG4107TY6 Acylneuraminate cytidylyltransferase HC658_37840 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HC658_37850 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HC658_37920 ENOG4105C26 Dehydrogenase HC658_37930 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HC658_37940 ENOG4108RJ9 Glycosyl transferase, family 2 HC658_37950 ENOG4105DWF phosphomethylpyrimidine kinase HC658_37980 ENOG4105C5Y PTS System HC658_37990 ENOG4108QTI )-transporter HC658_38020 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HC658_38030 ENOG4105DEN Luciferase family HC658_38040 ENOG4108DBC nitroreductase HC658_38070 ENOG41060D1 Quinol oxidase HC658_38080 ENOG4105CCU oxidase (Subunit III) HC658_38090 ENOG4105BZ9 Cytochrome C oxidase, subunit I HC658_38100 ENOG4105E2S oxidase) subunit II HC658_38110 ENOG4107BMA Transglycosylase associated protein HC658_38130 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HC658_38140 ENOG4105WH5 Teichoic acid glycosylation protein HC658_38190 ENOG4107ZXU DSBA oxidoreductase HC658_38200 ENOG4105DBE peroxidase HC658_38210 ENOG410650H (LipO)protein HC658_38220 ENOG4107SJW iron permease, FTR1 HC658_38230 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HC658_38250 ENOG4105CMU LysR family (Transcriptional regulator HC658_38260 ENOG4105VAW lrga family HC658_38270 ENOG41067MG lrgb family HC658_38280 ENOG4105D8G Major Facilitator superfamily HC658_38300 ENOG4105DR4 Methyltransferase HC658_38330 ENOG4108YV3 Protein of unknown function (DUF2711) HC658_38340 ENOG4105CK1 PTS System HC658_38350 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HC658_38380 ENOG4105X1N Glycosyl transferase family 8 HC658_38400 ENOG4105GVJ transcriptional regulator HC658_38410 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HC658_38420 ENOG4105IIU Aminopeptidase HC658_38470 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HC658_38490 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HC658_38500 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HC658_38520 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HC658_38530 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HC658_38540 ENOG4105CM2 brancheD-chain amino acid aminotransferase HC658_38550 ENOG4105F8D glycoside hydrolase family 4 HC658_38560 ENOG4105VCP PTS System HC658_38570 ENOG4105CK1 PTS System HC658_38580 ENOG4105VZJ PTS System HC658_38590 ENOG4105EMD TRANSCRIPTIONal HC658_38610 ENOG4108VX5 3-methyladenine DNA glycosylase HC658_38620 ENOG4105CH6 catalase HC658_38650 ENOG4105DA5 (ABC) transporter HC658_38660 ENOG41069JR HC658_38700 ENOG4105ETS cytosine purines uracil thiamine allantoin HC658_38710 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HC658_38720 ENOG4108JJ8 (ABC) transporter HC658_38730 ENOG4108JJ9 ABC, transporter HC658_38740 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HC658_38750 ENOG4105C4M (Ubiquinol oxidase) subunit I HC658_38760 ENOG4105D2K citrate carrier protein HC658_38780 ENOG4107BJW polysaccharide deacetylase HC658_38820 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HC658_38840 ENOG4105CMR udp-glucose 4-epimerase HC658_38860 ENOG4105BZU Histidine kinase HC658_38870 ENOG4105WH1 Two component transcriptional regulator luxr family HC658_38880 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HC658_38930 ENOG4105DTD Dehydrogenase HC658_38940 ENOG4108IIH CoA-transferase subunit B HC658_38950 ENOG4105D6N CoA-transferase, subunit a HC658_38960 ENOG4105CY2 Citrate transporter HC658_38970 ENOG4105DHI Methyltransferase HC658_39010 ENOG4105CH6 catalase HC658_39020 ENOG4105D4T Citrate transporter HC658_39030 ENOG4108RZ2 Glycoside hydrolase family 16 HC658_39040 ENOG4105CID antiterminator HC658_39060 ENOG4105DEU major facilitator superfamily HC658_39070 ENOG4105C1J atp-dependent rna helicase HC658_39080 ENOG4107TDE lipolytic protein G-D-S-L family HC658_39190 ENOG4105CNA YD repeat protein HC658_39210 ENOG4107YZX Universal stress protein HC658_39220 ENOG4105CS2 ec 3.2.1.21 HC658_39230 ENOG4105C5Y PTS System HC658_39260 ENOG4107EV6 Inherit from COG: YD repeat protein HC658_39290 ENOG4107EV6 Inherit from COG: YD repeat protein HC658_39320 ENOG4106Z5D Glycoside Hydrolase Family 43 HC658_39350 ENOG4105C84 Histidine ammonia-lyase HC658_39360 ENOG4105CGP Urocanate hydratase HC658_39370 ENOG4105CI2 imidazolone-5-propionate hydrolase HC658_39380 ENOG4107W25 arginase agmatinase formiminoglutamase HC658_39400 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HC658_39410 ENOG4105D9N nucleoside HC658_39430 ENOG4107RHR regulatoR HC658_39440 ENOG4108TM9 integral membrane protein HC658_39450 ENOG4105ENY Ethanolamine utilization protein eutH HC658_39460 ENOG4108PGP mmge prpd family protein HC658_39490 ENOG4108HW4 amino acid AbC transporter HC658_39500 ENOG4105EAB amino acid AbC transporter HC658_39530 ENOG4107QHE Choloylglycine hydrolase HC658_39540 ENOG410667J hydrolase HC658_39600 ENOG4108V5C ABC transporter HC658_39660 ENOG4105D2N Aldolase HC658_39670 ENOG4107TRN Xylose isomerase domain protein TIM barrel HC658_39680 ENOG4105F0H myo-inositol catabolism protein HC658_39690 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HC658_39710 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HC658_39720 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HC658_39730 ENOG4105D7K pfkb domain protein HC658_39740 ENOG4105DH8 myo-inositol catabolism HC658_39750 ENOG4105C26 Dehydrogenase HC658_39770 ENOG4105CPC Aldo Keto reductase HC658_39810 ENOG4107QNK )-transporter HC658_39820 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HC658_39840 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HC658_39850 ENOG4105ST3 Transcriptional regulator HC658_39860 ENOG4105C26 Dehydrogenase HC658_39880 ENOG4108ITS PQQ enzyme repeat HC658_39900 ENOG41085PJ rdd domain containing protein HC658_39930 ENOG4105J7D transcriptional regulator HC658_39940 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HC658_39950 ENOG41061AU MarR family Transcriptional regulator HC658_39970 ENOG41067MG lrgb family HC658_39990 ENOG4105BZW Glycerate kinase HC658_40000 ENOG4105G3Z GntR family transcriptional regulator HC658_40010 ENOG4105CMG Carbohydrate kinase HC658_40020 ENOG4105C6Z Gluconate HC658_40030 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HC658_40040 ENOG4105D3R alkyl hydroperoxide reductase HC658_40050 ENOG4108JU3 Alkyl hydroperoxide reductase HC658_40060 ENOG4105CS2 ec 3.2.1.21 HC658_40070 ENOG4105C5Y PTS System HC658_40080 ENOG4108S3Y transcriptional regulator HC658_40090 ENOG4106KKU HC658_40100 ENOG4108Z15 abc transporter atp-binding protein HC658_40110 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HC658_40130 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HC658_40160 ENOG4105E2A Dehydrogenase HC658_40200 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HC658_40210 ENOG4105WQG acetyltransferase HC658_40220 ENOG410780I phosphoprotein phosphatase activity HC658_40240 ENOG41066UZ arginase EC 3.5.3.1 HC658_40250 ENOG4108IQI permease HC658_40260 ENOG4105C8Y Acetylornithine aminotransferase HC658_40270 ENOG4108JUB Transcriptional regulator HC658_40280 ENOG4105BZU Histidine kinase HC658_40320 ENOG4105C0H protease HC658_40330 ENOG4105Q2H domain protein HC658_40360 ENOG4105BZU Histidine kinase HC658_40370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC658_40420 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HC658_40430 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HC658_40440 ENOG4105CDU Replicative dna helicase HC658_40480 ENOG4105DJ2 Major Facilitator Superfamily HC658_40490 ENOG4105EDW glycosyl transferase, family 39 HC658_40500 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HC658_40510 ENOG4105BZR domain protein HC658_40520 ENOG4108XMW Membrane HC658_40550 ENOG4105KVH Transcriptional regulator HC658_40560 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HC658_40610 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HC658_40640 ENOG41060CM Protein of unknown function (DUF2712) HC658_40650 ENOG4106NWU HC658_40660 ENOG41064J9 HC658_40670 ENOG41064SH Protein of unknown function (DUF2705) HC658_40680 ENOG4108RDQ ABC transporter HC658_40700 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HC658_40710 ENOG4105DDN Pentapeptide repeat-containing protein HC658_40720 ENOG4105D94 Major Facilitator Superfamily HC658_40730 ENOG4107RSM transcriptional regulator HC658_40740 ENOG41082BV acetyltransferase HC658_40750 ENOG41081I9 integral membrane protein HC658_40770 ENOG4108U05 Transcriptional regulator HC658_40780 ENOG41082BV acetyltransferase HC658_40800 ENOG4108U7W acetyltransferase HC658_40810 ENOG4105UNS Pfam:DUF419 HC658_40820 ENOG4105NAE bifunctional deaminase-reductase domain protein HC658_40830 ENOG4108J8C transporter major facilitator family protein HC658_40840 ENOG4105C7Z Conserved Protein HC658_40880 ENOG4108IPJ Membrane HC658_40890 ENOG4105C7Z Conserved Protein HC658_40900 ENOG4105N14 lysine exporter protein LysE YggA HC658_40920 ENOG4105C7Z Conserved Protein HC658_40930 ENOG4107FCW Abortive infection protein HC658_40950 ENOG4108UW5 maltose o-acetyltransferase HC658_40960 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HC658_40980 ENOG4105CGK Exodeoxyribonuclease III HC658_40990 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HC658_41000 ENOG4108UUM single-stranded DNA-binding protein HC658_41010 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HC658_41020 ENOG4105C3G gtp-binding protein HC658_41030 ENOG4108J2R molybdopterin oxidoreductase HC658_41040 ENOG4105VDK protein, conserved in bacteria HC658_41060 ENOG4108ZDA Sporulation protein YyaC HC658_41070 ENOG4105FA0 parb-like partition protein HC658_41080 ENOG4107QJE Chromosome Partitioning Protein HC658_41110 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HC658_41120 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HC658_41130 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HC658_41160 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)