locus-tag	class	description
HC658_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC658_00020	COG0592	DNA-directed DNA polymerase activity
HC658_00030	COG2501	S4 domain
HC658_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC658_00060	COG0187	DNA topoisomerase II activity
HC658_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC658_00140	COG0517	IMP dehydrogenase activity
HC658_00140	COG0516	GMP reductase activity
HC658_00150	COG1686	Belongs to the peptidase S11 family
HC658_00160	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HC658_00170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HC658_00180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC658_00200	COG1428	Deoxynucleoside kinase
HC658_00210	COG1428	Deoxynucleoside kinase
HC658_00220	COG3858	chitin binding
HC658_00220	COG1388	LysM domain
HC658_00230	COG1335	isochorismatase
HC658_00240	COG0590	tRNA wobble adenosine to inosine editing
HC658_00260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HC658_00270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC658_00280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC658_00370	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HC658_00380	COG3853	Toxic anion resistance protein (TelA)
HC658_00390	COG1982	Orn Lys Arg decarboxylase major
HC658_00400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC658_00410	COG3870	Protein conserved in bacteria
HC658_00420	COG1728	Protein conserved in bacteria
HC658_00430	COG0470	DNA polymerase III
HC658_00440	COG1774	PSP1 C-terminal conserved region
HC658_00450	COG4467	Involved in initiation control of chromosome replication
HC658_00460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HC658_00470	COG2827	Endonuclease containing a URI domain
HC658_00480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC658_00490	COG2002	toxin-antitoxin pair type II binding
HC658_00500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_00500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_00510	COG0084	hydrolase, TatD family'
HC658_00520	COG3584	3D domain protein
HC658_00520	COG3583	domain protein
HC658_00530	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC658_00540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC658_00560	COG4466	Protein conserved in bacteria
HC658_00580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC658_00590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC658_00600	COG0251	oxidation-reduction process
HC658_00610	COG2088	sporulation resulting in formation of a cellular spore
HC658_00620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC658_00630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC658_00640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HC658_00650	COG0193	aminoacyl-tRNA hydrolase activity
HC658_00670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC658_00680	COG2002	toxin-antitoxin pair type II binding
HC658_00690	COG2244	polysaccharide biosynthetic process
HC658_00700	COG3956	TIGRFAM MazG family protein
HC658_00710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC658_00740	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HC658_00750	COG1098	S1 RNA binding domain
HC658_00780	COG2208	phosphoserine phosphatase activity
HC658_00790	COG2304	oxidoreductase activity
HC658_00800	COG0515	serine threonine protein kinase
HC658_00810	COG0037	tRNA processing
HC658_00830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC658_00840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HC658_00850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HC658_00860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC658_00870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC658_00880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC658_00890	COG0512	Glutamine amidotransferase of anthranilate synthase
HC658_00900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC658_00910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC658_00920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC658_00930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC658_00940	COG1396	sequence-specific DNA binding
HC658_00950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC658_00960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC658_01120	COG4463	regulation of RNA biosynthetic process
HC658_01130	COG3880	PFAM UvrB UvrC protein
HC658_01140	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HC658_01150	COG0542	response to heat
HC658_01160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC658_01170	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HC658_01180	COG4956	integral membrane protein (PIN domain superfamily)
HC658_01190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HC658_01200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HC658_01210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC658_01220	COG1045	serine acetyltransferase
HC658_01230	COG0215	cysteine-tRNA ligase activity
HC658_01240	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HC658_01250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC658_01260	COG3688	RNA-binding protein containing a PIN domain
HC658_01270	COG1595	DNA-templated transcription, initiation
HC658_01290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC658_01300	COG0250	Participates in transcription elongation, termination and antitermination
HC658_01320	COG0081	regulation of translation
HC658_01330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC658_01350	COG2813	Specifically methylates the guanine in position
HC658_01360	COG0085	RNA polymerase activity
HC658_01370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC658_01380	COG1358	cellular component organization or biogenesis
HC658_01390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HC658_01400	COG0049	tRNA binding
HC658_01410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC658_01420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC658_01430	COG0596	Alpha beta hydrolase
HC658_01450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC658_01460	COG0088	Forms part of the polypeptide exit tunnel
HC658_01480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC658_01510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HC658_01520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC658_01540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC658_01550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC658_01570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC658_01590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC658_01600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC658_01610	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HC658_01640	COG0200	Binds to the 23S rRNA
HC658_01650	COG0201	protein transport
HC658_01660	COG0563	adenylate kinase activity
HC658_01670	COG0024	Methionine aminopeptidase
HC658_01680	COG2163	COG2163 Ribosomal protein L14E L6E L27E
HC658_01700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC658_01710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HC658_01730	COG0202	RNA polymerase activity
HC658_01740	COG0203	ribosomal protein L17
HC658_01750	COG1122	ATPase activity
HC658_01760	COG1122	ATPase activity
HC658_01770	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC658_01780	COG0101	tRNA pseudouridine synthase activity
HC658_01790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC658_01800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HC658_01810	COG2226	methyltransferase
HC658_01830	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_01840	COG0489	protein tyrosine kinase activity
HC658_01860	COG2194	sulfuric ester hydrolase activity
HC658_01870	COG0726	polysaccharide deacetylase
HC658_02040	COG0659	secondary active sulfate transmembrane transporter activity
HC658_02050	COG0385	Bile acid
HC658_02060	COG2819	hydrolase of the alpha beta superfamily
HC658_02070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_02080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_02090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_02100	COG2207	Transcriptional regulator
HC658_02100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_02110	COG3876	Protein conserved in bacteria
HC658_02120	COG1472	Belongs to the glycosyl hydrolase 3 family
HC658_02130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC658_02140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_02140	COG1263	PTS System
HC658_02150	COG1737	Transcriptional regulator
HC658_02160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HC658_02170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_02180	COG1683	Conserved Protein
HC658_02240	COG1595	DNA-templated transcription, initiation
HC658_02250	COG5662	AntiSigma factor
HC658_02260	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC658_02270	COG4856	YbbR-like protein
HC658_02280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC658_02290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC658_02300	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC658_02310	COG2169	Transcriptional regulator
HC658_02320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC658_02330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC658_02340	COG3002	Belongs to the UPF0753 family
HC658_02350	COG0288	reversible hydration of carbon dioxide
HC658_02370	COG5609	conserved protein (DUF2294)
HC658_02380	COG0640	Transcriptional regulator
HC658_02390	COG2814	Major facilitator Superfamily
HC658_02400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC658_02420	COG0535	radical SAM domain protein
HC658_02430	COG1266	CAAX protease self-immunity
HC658_02440	COG1131	(ABC) transporter
HC658_02460	COG1413	lyase activity
HC658_02470	COG0596	Alpha beta hydrolase
HC658_02480	COG0745	RESPONSE REGULATOR receiver
HC658_02490	COG0642	Histidine kinase
HC658_02510	COG0515	serine threonine protein kinase
HC658_02540	COG1113	amino acid transport
HC658_02570	COG2602	Beta-lactamase
HC658_02580	COG2124	cytochrome p450
HC658_02600	COG0531	amino acid
HC658_02610	COG0584	glycerophosphoryl diester phosphodiesterase
HC658_02620	COG2271	Major facilitator Superfamily
HC658_02640	COG1846	Transcriptional regulator
HC658_02640	COG0456	acetyltransferase
HC658_02650	COG2271	Major facilitator Superfamily
HC658_02680	COG3409	Peptidoglycan-binding domain 1 protein
HC658_02690	COG0697	spore germination
HC658_02700	COG2207	Transcriptional regulator
HC658_02700	COG1917	Cupin 2, conserved barrel domain protein
HC658_02710	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HC658_02720	COG3591	Belongs to the peptidase S1B family
HC658_02740	COG0596	Alpha beta hydrolase
HC658_02750	COG1183	phosphatidylcholine synthase activity
HC658_02760	COG0586	Pfam SNARE associated Golgi protein
HC658_02770	COG0688	phosphatidylethanolamine metabolic process
HC658_02790	COG2312	Erythromycin esterase
HC658_02800	COG2207	Transcriptional regulator
HC658_02820	COG1301	dicarboxylic acid transport
HC658_02830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_02830	COG2190	(PTS) system
HC658_02830	COG1263	PTS System
HC658_02840	COG0363	glucosamine-6-phosphate deaminase activity
HC658_02850	COG2188	Transcriptional regulator
HC658_02870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC658_02880	COG0833	amino acid
HC658_02890	COG2040	homocysteine
HC658_02900	COG1115	amino acid carrier protein
HC658_02910	COG2066	Belongs to the glutaminase family
HC658_02920	COG4191	Histidine kinase
HC658_02930	COG0784	Response regulator, receiver
HC658_02940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC658_02950	COG1012	belongs to the aldehyde dehydrogenase family
HC658_02960	COG2271	Major facilitator Superfamily
HC658_02970	COG4948	Mandelate Racemase Muconate Lactonizing
HC658_02980	COG2186	Transcriptional regulator
HC658_02990	COG2721	sulfolactate sulfo-lyase activity
HC658_03000	COG3173	Aminoglycoside phosphotransferase
HC658_03020	COG0697	spore germination
HC658_03030	COG0745	RESPONSE REGULATOR receiver
HC658_03040	COG2205	protein histidine kinase activity
HC658_03050	COG1131	(ABC) transporter
HC658_03080	COG3773	Cell wall hydrolase
HC658_03090	COG2304	oxidoreductase activity
HC658_03110	COG3540	Alkaline phosphatase
HC658_03120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC658_03130	COG0805	protein transport
HC658_03140	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HC658_03150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC658_03160	COG0477	Major facilitator Superfamily
HC658_03170	COG1309	transcriptional regulator
HC658_03180	COG0252	asparaginase activity
HC658_03190	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC658_03200	COG1714	RDD family
HC658_03210	COG1405	negative regulation of cell septum assembly
HC658_03210	COG3012	SEC-C Motif Domain Protein
HC658_03220	COG3290	protein histidine kinase activity
HC658_03230	COG3279	Response regulator of the LytR AlgR family
HC658_03240	COG4555	ABC transporter
HC658_03250	COG1668	transmembrane transport
HC658_03260	COG0667	Aldo Keto reductase
HC658_03280	COG1595	DNA-templated transcription, initiation
HC658_03290	COG1595	DNA-templated transcription, initiation
HC658_03300	COG1876	peptidase activity
HC658_03310	COG0457	Tetratricopeptide repeat
HC658_03320	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_03330	COG0366	Alpha amylase catalytic
HC658_03340	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC658_03350	COG1121	(ABC) transporter
HC658_03360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC658_03370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_03380	COG2310	stress, protein
HC658_03390	COG2310	stress, protein
HC658_03400	COG2310	stress, protein
HC658_03410	COG0861	Integral membrane protein TerC family
HC658_03430	COG3853	Toxic anion resistance protein (TelA)
HC658_03440	COG0477	Major facilitator Superfamily
HC658_03450	COG2814	Major facilitator Superfamily
HC658_03460	COG0640	Transcriptional regulator
HC658_03470	COG4175	Glycine betaine
HC658_03470	COG0517	IMP dehydrogenase activity
HC658_03480	COG4176	ABC-type proline glycine betaine transport system permease component
HC658_03490	COG2113	Glycine betaine
HC658_03500	COG1473	amidohydrolase
HC658_03510	COG1288	antiporter activity
HC658_03530	COG0366	Alpha amylase catalytic
HC658_03540	COG0039	L-malate dehydrogenase activity
HC658_03550	COG1620	l-lactate permease
HC658_03560	COG2814	Major facilitator Superfamily
HC658_03570	COG1846	Transcriptional regulator
HC658_03580	COG1280	lysine exporter protein (LysE YggA)
HC658_03590	COG3403	YqcI/YcgG family
HC658_03600	COG1113	amino acid transport
HC658_03610	COG3665	Urea carboxylase-associated protein
HC658_03620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HC658_03630	COG1660	Displays ATPase and GTPase activities
HC658_03640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC658_03650	COG2226	methyltransferase
HC658_03660	COG0583	DNA-binding transcription factor activity
HC658_03670	COG3458	cephalosporin-C deacetylase activity
HC658_03680	COG3541	Predicted nucleotidyltransferase
HC658_03690	COG0506	proline dehydrogenase activity
HC658_03700	COG1012	belongs to the aldehyde dehydrogenase family
HC658_03710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_03720	COG2508	Transcriptional regulator
HC658_03730	COG3689	TIGRFAM TIGR03943 family protein
HC658_03740	COG0701	Predicted permease
HC658_03750	COG2267	carboxylic ester hydrolase activity
HC658_03760	COG0492	ferredoxin-NADP+ reductase activity
HC658_03770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC658_03770	COG1587	Uroporphyrinogen-III synthase
HC658_03780	COG2146	nitrite reductase [NAD(P)H] activity
HC658_03790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC658_03800	COG0243	molybdopterin cofactor binding
HC658_03810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC658_03820	COG2223	nitrite transmembrane transporter activity
HC658_03830	COG1469	GTP cyclohydrolase I activity
HC658_03840	COG1376	ErfK ybiS ycfS ynhG family protein
HC658_03860	COG0523	cobalamin synthesis protein
HC658_03870	COG0765	amino acid transport
HC658_03880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_03890	COG1714	RDD family
HC658_03910	COG2723	6-phospho-beta-galactosidase activity
HC658_03930	COG3209	COG3209 Rhs family protein
HC658_03940	COG3290	protein histidine kinase activity
HC658_03940	COG0840	transmembrane signaling receptor activity
HC658_03950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HC658_03960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HC658_03970	COG1733	regulation of RNA biosynthetic process
HC658_03980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_03990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_04000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_04010	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC658_04020	COG2814	Major facilitator Superfamily
HC658_04040	COG0697	spore germination
HC658_04050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_04070	COG2364	Membrane
HC658_04080	COG1126	abc transporter atp-binding protein
HC658_04090	COG0765	amino acid transport
HC658_04100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_04110	COG0583	DNA-binding transcription factor activity
HC658_04120	COG0163	prenyltransferase activity
HC658_04130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC658_04150	COG0596	Alpha beta hydrolase
HC658_04160	COG3104	oligopeptide transport
HC658_04170	COG5434	Belongs to the glycosyl hydrolase 28 family
HC658_04190	COG0697	spore germination
HC658_04210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC658_04220	COG1136	(ABC) transporter
HC658_04230	COG0577	efflux transmembrane transporter activity
HC658_04240	COG0745	RESPONSE REGULATOR receiver
HC658_04250	COG5002	protein histidine kinase activity
HC658_04250	COG3850	Histidine kinase
HC658_04260	COG0457	Tetratricopeptide repeat
HC658_04280	COG0527	aspartate kinase activity
HC658_04290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_04300	COG4605	iron ion homeostasis
HC658_04310	COG4604	ABC transporter, ATP-binding protein
HC658_04320	COG4607	ABC-type enterochelin transport system periplasmic component
HC658_04330	COG2814	Major facilitator Superfamily
HC658_04340	COG1309	transcriptional regulator
HC658_04350	COG0778	Nitroreductase
HC658_04360	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC658_04370	COG0640	Transcriptional regulator
HC658_04380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_04390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC658_04400	COG1012	belongs to the aldehyde dehydrogenase family
HC658_04410	COG4975	Glucose uptake
HC658_04420	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_04430	COG4549	nuclear export factor GLE1
HC658_04440	COG1276	copper resistance
HC658_04440	COG2372	response to copper ion
HC658_04450	COG1349	DNA-binding transcription factor activity
HC658_04470	COG2213	PTS system mannitol-specific
HC658_04480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_04490	COG0246	Mannitol dehydrogenase
HC658_04500	COG0473	3-isopropylmalate dehydrogenase activity
HC658_04520	COG0681	Belongs to the peptidase S26 family
HC658_04530	COG0412	Dienelactone hydrolase
HC658_04540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC658_04560	COG0561	phosphatase activity
HC658_04570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HC658_04580	COG1914	H( )-stimulated, divalent metal cation uptake system
HC658_04590	COG4336	lyase activity
HC658_04600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC658_04610	COG1984	allophanate hydrolase subunit 2
HC658_04620	COG1414	Transcriptional regulator
HC658_04630	COG2755	lipolytic protein G-D-S-L family
HC658_04650	COG2329	Antibiotic biosynthesis monooxygenase
HC658_04660	COG0768	penicillin binding
HC658_04670	COG4989	oxidoreductase activity
HC658_04680	COG3711	transcriptional antiterminator
HC658_04690	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_04700	COG2226	methyltransferase
HC658_04710	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_04720	COG1917	Cupin 2, conserved barrel domain protein
HC658_04730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_04740	COG3871	stress protein (general stress protein 26)
HC658_04770	COG2814	Major facilitator Superfamily
HC658_04780	COG1522	sequence-specific DNA binding
HC658_04790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC658_04790	COG0551	DNA topoisomerase type I activity
HC658_04800	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HC658_04810	COG3706	GGDEF domain
HC658_04820	COG5298	Protein conserved in bacteria
HC658_04830	COG1215	transferase activity, transferring glycosyl groups
HC658_04850	COG0531	amino acid
HC658_04860	COG0494	nUDIX hydrolase
HC658_04870	COG0028	Belongs to the TPP enzyme family
HC658_04890	COG1914	H( )-stimulated, divalent metal cation uptake system
HC658_04900	COG2261	transglycosylase associated protein
HC658_04910	COG4876	unkown
HC658_04920	COG2217	Heavy metal translocating P-type atpase
HC658_04930	COG3729	General stress protein
HC658_04940	COG0662	Cupin 2, conserved barrel domain protein
HC658_04950	COG2329	Antibiotic biosynthesis monooxygenase
HC658_04960	COG3546	catalase activity
HC658_04970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HC658_04980	COG3290	protein histidine kinase activity
HC658_04990	COG4565	transcriptional regulatory protein
HC658_05000	COG1301	dicarboxylic acid transport
HC658_05010	COG0628	permease
HC658_05020	COG1131	(ABC) transporter
HC658_05030	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC658_05050	COG1960	acyl-CoA dehydrogenase activity
HC658_05080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC658_05090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_05100	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC658_05110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC658_05120	COG0513	Belongs to the DEAD box helicase family
HC658_05130	COG3402	PFAM membrane-flanked domain
HC658_05140	COG3428	Bacterial PH domain
HC658_05150	COG0705	Rhomboid family
HC658_05160	COG0736	holo-[acyl-carrier-protein] synthase activity
HC658_05170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HC658_05180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC658_05190	COG0864	Transcriptional regulator
HC658_05200	COG2337	Toxic component of a toxin-antitoxin (TA) module
HC658_05210	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_05220	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_05230	COG2172	sigma factor antagonist activity
HC658_05240	COG2208	phosphoserine phosphatase activity
HC658_05250	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_05260	COG2172	sigma factor antagonist activity
HC658_05270	COG1191	sigma factor activity
HC658_05280	COG2208	phosphoserine phosphatase activity
HC658_05290	COG2183	response to ionizing radiation
HC658_05310	COG3091	SprT-like family
HC658_05390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_05410	COG5444	nuclease activity
HC658_05420	COG1476	TRANSCRIPTIONal
HC658_05440	COG3239	Fatty acid desaturase
HC658_05450	COG1278	Cold shock
HC658_05460	COG1329	Transcriptional regulator
HC658_05470	COG0697	spore germination
HC658_05480	COG1917	Cupin 2, conserved barrel domain protein
HC658_05480	COG2207	Transcriptional regulator
HC658_05490	COG0697	spore germination
HC658_05500	COG2207	Transcriptional regulator
HC658_05500	COG3708	Transcriptional regulator
HC658_05510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_05520	COG0477	Major facilitator Superfamily
HC658_05540	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HC658_05570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_05580	COG1309	transcriptional regulator
HC658_05590	COG0697	spore germination
HC658_05600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_05610	COG2030	dehydratase
HC658_05620	COG3545	Serine hydrolase
HC658_05630	COG1733	regulation of RNA biosynthetic process
HC658_05640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_05650	COG2814	Major facilitator Superfamily
HC658_05660	COG1309	transcriptional regulator
HC658_05680	COG0640	Transcriptional regulator
HC658_05690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC658_05710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_05720	COG0697	spore germination
HC658_05730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_05740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC658_05750	COG0640	Transcriptional regulator
HC658_05760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC658_05770	COG4585	Histidine kinase
HC658_05780	COG2197	response regulator
HC658_05790	COG2409	Drug exporters of the RND superfamily
HC658_05800	COG0596	Alpha beta hydrolase
HC658_05810	COG1811	Na channel or pump
HC658_05820	COG0789	Transcriptional regulator
HC658_05820	COG4978	Transcriptional regulator
HC658_05830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC658_05840	COG0778	Nitroreductase
HC658_05850	COG0346	lactoylglutathione lyase activity
HC658_05860	COG2259	Doxx family
HC658_05870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_05910	COG2323	membrane
HC658_05920	COG2323	membrane
HC658_05930	COG0071	Belongs to the small heat shock protein (HSP20) family
HC658_05960	COG1309	transcriptional regulator
HC658_05980	COG0456	acetyltransferase
HC658_06000	COG1113	amino acid transport
HC658_06010	COG2318	DinB family
HC658_06020	COG1846	Transcriptional regulator
HC658_06030	COG2409	Drug exporters of the RND superfamily
HC658_06030	COG1033	growth of symbiont in host cell
HC658_06040	COG0778	Nitroreductase
HC658_06050	COG1846	Transcriptional regulator
HC658_06060	COG2814	Major facilitator Superfamily
HC658_06070	COG0730	response to heat
HC658_06080	COG1802	Transcriptional regulator
HC658_06090	COG1388	LysM domain
HC658_06090	COG3858	chitin binding
HC658_06100	COG1819	glycosyl
HC658_06120	COG1785	Belongs to the alkaline phosphatase family
HC658_06130	COG5646	InterPro IPR014922
HC658_06150	COG0454	-acetyltransferase
HC658_06160	COG1078	dGTPase activity
HC658_06170	COG1388	LysM domain
HC658_06180	COG2814	Major facilitator Superfamily
HC658_06190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_06200	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC658_06210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_06220	COG2723	6-phospho-beta-galactosidase activity
HC658_06230	COG2188	Transcriptional regulator
HC658_06240	COG1940	carbohydrate kinase activity
HC658_06250	COG1482	cell wall glycoprotein biosynthetic process
HC658_06260	COG4124	Belongs to the glycosyl hydrolase 26 family
HC658_06350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HC658_06360	COG0802	atpase or kinase
HC658_06370	COG1214	PFAM Peptidase M22, glycoprotease
HC658_06380	COG0456	acetyltransferase
HC658_06390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC658_06400	COG0488	(ABC) transporter
HC658_06410	COG0315	cyclic pyranopterin monophosphate synthase activity
HC658_06420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HC658_06430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC658_06440	COG0805	protein transport
HC658_06460	COG1266	CAAX protease self-immunity
HC658_06480	COG0459	protein refolding
HC658_06490	COG3378	Phage plasmid primase P4 family
HC658_06510	COG0270	DNA (cytosine-5-)-methyltransferase activity
HC658_06520	COG0270	DNA (cytosine-5-)-methyltransferase activity
HC658_06540	COG1401	restriction endodeoxyribonuclease activity
HC658_06570	COG0457	Tetratricopeptide repeat
HC658_06580	COG1063	alcohol dehydrogenase
HC658_06590	COG2211	Major facilitator Superfamily
HC658_06600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_06610	COG1842	Phage shock protein A
HC658_06620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC658_06630	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HC658_06640	COG4260	virion core protein, lumpy skin disease virus
HC658_06660	COG2814	Major facilitator Superfamily
HC658_06670	COG1063	alcohol dehydrogenase
HC658_06680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC658_06690	COG0823	Involved in the tonB-independent uptake of proteins
HC658_06720	COG2267	carboxylic ester hydrolase activity
HC658_06740	COG2132	Multicopper oxidase
HC658_06750	COG1113	amino acid transport
HC658_06760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC658_06770	COG0714	Associated with various cellular activities
HC658_06780	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HC658_06790	COG1305	Transglutaminase-like
HC658_06800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC658_06800	COG0519	Catalyzes the synthesis of GMP from XMP
HC658_06810	COG2252	PERMEase
HC658_06820	COG3064	Membrane
HC658_06840	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HC658_06860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC658_06870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC658_06880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC658_06890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC658_06900	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC658_06910	COG0047	phosphoribosylformylglycinamidine synthase activity
HC658_06920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC658_06930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC658_06940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC658_06950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC658_06960	COG0138	bifunctional purine biosynthesis protein purh
HC658_06970	COG0151	Belongs to the GarS family
HC658_06980	COG1522	sequence-specific DNA binding
HC658_06990	COG0531	amino acid
HC658_07010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC658_07020	COG1470	cell adhesion involved in biofilm formation
HC658_07030	COG4496	protein, YerC YecD
HC658_07040	COG0069	glutamate synthase activity
HC658_07050	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HC658_07060	COG0210	DNA helicase
HC658_07070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC658_07080	COG4851	CamS sex pheromone cAM373 precursor
HC658_07090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_07100	COG1285	pathogenesis
HC658_07110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_07120	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC658_07130	COG0154	amidase activity
HC658_07140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC658_07150	COG1309	transcriptional regulator
HC658_07160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC658_07170	COG1597	lipid kinase activity
HC658_07180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC658_07190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC658_07200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC658_07210	COG1002	Type II restriction enzyme, methylase subunits
HC658_07220	COG1061	Type III restriction enzyme res subunit
HC658_07230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC658_07270	COG5444	nuclease activity
HC658_07280	COG3391	amine dehydrogenase activity
HC658_07310	COG0457	Tetratricopeptide repeat
HC658_07330	COG0217	transcriptional regulatory protein
HC658_07350	COG1309	transcriptional regulator
HC658_07360	COG3631	Ketosteroid isomerase-related protein
HC658_07370	COG0702	epimerase
HC658_07400	COG3546	catalase activity
HC658_07410	COG0454	-acetyltransferase
HC658_07430	COG5578	integral membrane protein
HC658_07440	COG2972	Histidine kinase
HC658_07450	COG4753	response regulator
HC658_07450	COG2207	Transcriptional regulator
HC658_07460	COG1653	transport
HC658_07470	COG1175	transmembrane transport
HC658_07480	COG0395	ABC-type sugar transport system, permease component
HC658_07490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC658_07500	COG2207	Transcriptional regulator
HC658_07510	COG2755	lipolytic protein G-D-S-L family
HC658_07530	COG5578	integral membrane protein
HC658_07540	COG3401	FG-GAP repeat protein
HC658_07550	COG3401	FG-GAP repeat protein
HC658_07560	COG2755	lipolytic protein G-D-S-L family
HC658_07570	COG1874	Beta-galactosidase
HC658_07590	COG1653	transport
HC658_07600	COG4209	transmembrane transport
HC658_07610	COG0395	ABC-type sugar transport system, permease component
HC658_07620	COG1486	melibiose metabolic process
HC658_07630	COG2323	membrane
HC658_07640	COG2329	Antibiotic biosynthesis monooxygenase
HC658_07650	COG0346	lactoylglutathione lyase activity
HC658_07680	COG5583	Uncharacterized small protein (DUF2292)
HC658_07690	COG0670	Belongs to the BI1 family
HC658_07700	COG0697	spore germination
HC658_07710	COG1846	Transcriptional regulator
HC658_07720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC658_07740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC658_07740	COG2124	cytochrome p450
HC658_07750	COG1368	sulfuric ester hydrolase activity
HC658_07760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC658_07770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC658_07780	COG1442	glycosyl transferase family 8
HC658_07790	COG1216	Glycosyl transferase, family 2
HC658_07800	COG1442	glycosyl transferase family 8
HC658_07810	COG2223	nitrite transmembrane transporter activity
HC658_07820	COG1011	Hydrolase
HC658_07830	COG0531	amino acid
HC658_07840	COG1012	belongs to the aldehyde dehydrogenase family
HC658_07850	COG0840	transmembrane signaling receptor activity
HC658_07860	COG0488	(ABC) transporter
HC658_07880	COG0789	Transcriptional regulator
HC658_07890	COG2814	Major facilitator Superfamily
HC658_07920	COG0488	(ABC) transporter
HC658_07930	COG0513	Belongs to the DEAD box helicase family
HC658_07940	COG0456	acetyltransferase
HC658_07950	COG2130	NADP-dependent
HC658_07970	COG2211	Major facilitator Superfamily
HC658_07980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HC658_07990	COG1120	ATPase activity
HC658_08000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_08010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_08020	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC658_08050	COG3866	Pectate lyase
HC658_08060	COG0471	metal ion transport
HC658_08070	COG3290	protein histidine kinase activity
HC658_08080	COG4565	transcriptional regulatory protein
HC658_08090	COG3181	Tripartite tricarboxylate transporter family receptor
HC658_08100	COG2851	Citrate transporter
HC658_08110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_08120	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HC658_08130	COG1254	Belongs to the acylphosphatase family
HC658_08140	COG2258	MOSC domain
HC658_08180	COG0024	Methionine aminopeptidase
HC658_08190	COG1263	PTS System
HC658_08190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_08200	COG1368	sulfuric ester hydrolase activity
HC658_08220	COG1115	amino acid carrier protein
HC658_08230	COG0531	amino acid
HC658_08260	COG0697	spore germination
HC658_08270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_08270	COG1263	PTS System
HC658_08280	COG0366	Alpha amylase catalytic
HC658_08290	COG2188	Transcriptional regulator
HC658_08300	COG0778	Nitroreductase
HC658_08310	COG0737	Belongs to the 5'-nucleotidase family
HC658_08320	COG0693	protein deglycase activity
HC658_08330	COG2814	Major facilitator Superfamily
HC658_08340	COG4840	Belongs to the UPF0435 family
HC658_08350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC658_08360	COG4980	gas vesicle protein
HC658_08370	COG1295	ribonuclease BN
HC658_08380	COG0477	Major facilitator Superfamily
HC658_08390	COG0387	Pfam Sodium calcium exchanger
HC658_08410	COG0668	transmembrane transport
HC658_08420	COG0535	radical SAM domain protein
HC658_08440	COG0726	polysaccharide deacetylase
HC658_08450	COG2084	Dehydrogenase
HC658_08460	COG0598	Magnesium transport protein CorA
HC658_08470	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC658_08480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC658_08500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC658_08510	COG4637	Psort location Cytoplasmic, score
HC658_08530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC658_08540	COG0022	dehydrogenase e1 component
HC658_08550	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC658_08560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC658_08570	COG3284	Transcriptional regulator
HC658_08590	COG1742	UPF0060 membrane protein
HC658_08640	COG4842	Belongs to the WXG100 family
HC658_08650	COG1486	melibiose metabolic process
HC658_08660	COG1737	Transcriptional regulator
HC658_08670	COG1263	PTS System
HC658_08670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_08680	COG1132	(ABC) transporter
HC658_08690	COG1132	(ABC) transporter
HC658_08700	COG2259	Doxx family
HC658_08710	COG2514	catechol 2,3-dioxygenase activity
HC658_08720	COG4977	sequence-specific DNA binding
HC658_08720	COG1917	Cupin 2, conserved barrel domain protein
HC658_08730	COG2814	Major facilitator Superfamily
HC658_08740	COG1082	Xylose isomerase domain protein TIM barrel
HC658_08750	COG0673	inositol 2-dehydrogenase activity
HC658_08760	COG4585	Histidine kinase
HC658_08770	COG2197	response regulator
HC658_08780	COG1131	(ABC) transporter
HC658_08790	COG0842	Transport permease protein
HC658_08790	COG1511	domain protein
HC658_08800	COG0842	Transport permease protein
HC658_08810	COG1695	Transcriptional regulator
HC658_08820	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC658_08830	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HC658_08840	COG1309	transcriptional regulator
HC658_08850	COG2814	Major facilitator Superfamily
HC658_08860	COG2318	DinB family
HC658_08870	COG2814	Major facilitator Superfamily
HC658_08880	COG1846	Transcriptional regulator
HC658_08890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC658_08890	COG0392	lysyltransferase activity
HC658_08900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_08910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_08920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_08930	COG0384	phenazine biosynthesis protein PhzF
HC658_08940	COG0778	Nitroreductase
HC658_08970	COG1090	epimerase
HC658_08980	COG2137	regulation of response to DNA damage stimulus
HC658_09000	COG2814	Major facilitator Superfamily
HC658_09030	COG3103	Sh3 type 3 domain protein
HC658_09040	COG5658	integral membrane protein
HC658_09050	COG0596	Alpha beta hydrolase
HC658_09060	COG0463	Glycosyl transferase, family 2
HC658_09070	COG4485	Bacterial membrane protein, YfhO
HC658_09080	COG1988	membrane-bound metal-dependent
HC658_09090	COG1194	a g-specific adenine glycosylase
HC658_09110	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_09140	COG3557	Belongs to the UPF0374 family
HC658_09150	COG1132	(ABC) transporter
HC658_09160	COG4129	membrane
HC658_09170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC658_09180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC658_09190	COG0735	belongs to the Fur family
HC658_09410	COG4326	sporulation control protein
HC658_09430	COG5577	PFAM Coat F domain
HC658_09440	COG3340	Belongs to the peptidase S51 family
HC658_09450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HC658_09460	COG0277	FAD linked oxidase domain protein
HC658_09480	COG0753	catalase activity
HC658_09490	COG1116	anion transmembrane transporter activity
HC658_09500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC658_09510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC658_09520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_09540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC658_09560	COG1476	TRANSCRIPTIONal
HC658_09580	COG3382	B3 4 domain protein
HC658_09590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC658_09610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC658_09620	COG0789	Transcriptional regulator
HC658_09630	COG1664	Polymer-forming cytoskeletal
HC658_09640	COG1664	Polymer-forming cytoskeletal
HC658_09650	COG2766	serine protein kinase
HC658_09660	COG2718	Belongs to the UPF0229 family
HC658_09670	COG1846	Transcriptional regulator
HC658_09680	COG1566	PFAM secretion protein HlyD family protein
HC658_09690	COG2814	Major facilitator Superfamily
HC658_09700	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC658_09740	COG1725	Transcriptional regulator
HC658_09750	COG1131	(ABC) transporter
HC658_09760	COG1131	(ABC) transporter
HC658_09770	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC658_09780	COG1278	Cold shock
HC658_09790	COG1464	Belongs to the NlpA lipoprotein family
HC658_09800	COG3706	GGDEF domain
HC658_09810	COG1823	symporter activity
HC658_09850	COG5577	PFAM Coat F domain
HC658_09860	COG0737	Belongs to the 5'-nucleotidase family
HC658_09860	COG1525	nuclease
HC658_09860	COG4085	toxin activity
HC658_09870	COG3764	Sortase (surface protein transpeptidase)
HC658_09880	COG0564	pseudouridine synthase activity
HC658_09900	COG0517	IMP dehydrogenase activity
HC658_09910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC658_09920	COG3153	acetyltransferase
HC658_09920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC658_09940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC658_09950	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HC658_09960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC658_09970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC658_09980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC658_09990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC658_10000	COG4585	Histidine kinase
HC658_10000	COG2203	Gaf domain
HC658_10010	COG2197	response regulator
HC658_10020	COG0431	NADPH-dependent FMN reductase
HC658_10050	COG1388	LysM domain
HC658_10050	COG0791	NLP P60 protein
HC658_10060	COG1959	2 iron, 2 sulfur cluster binding
HC658_10070	COG0668	transmembrane transport
HC658_10080	COG2719	SpoVR family
HC658_10090	COG1785	Belongs to the alkaline phosphatase family
HC658_10100	COG1388	LysM domain
HC658_10100	COG0791	NLP P60 protein
HC658_10110	COG0583	DNA-binding transcription factor activity
HC658_10120	COG0372	Belongs to the citrate synthase family
HC658_10130	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_10140	COG0531	amino acid
HC658_10150	COG0733	neurotransmitter:sodium symporter activity
HC658_10160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_10170	COG0456	acetyltransferase
HC658_10200	COG1595	DNA-templated transcription, initiation
HC658_10210	COG0667	Aldo Keto reductase
HC658_10220	COG0204	Acyl-transferase
HC658_10230	COG1253	flavin adenine dinucleotide binding
HC658_10240	COG0789	Transcriptional regulator
HC658_10250	COG0436	Aminotransferase
HC658_10260	COG1253	flavin adenine dinucleotide binding
HC658_10270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC658_10280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC658_10290	COG0584	glycerophosphoryl diester phosphodiesterase
HC658_10310	COG0668	transmembrane transport
HC658_10320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC658_10330	COG0726	polysaccharide deacetylase
HC658_10340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC658_10350	COG1757	Na H antiporter
HC658_10360	COG0589	response to stress
HC658_10380	COG1132	(ABC) transporter
HC658_10390	COG1132	(ABC) transporter
HC658_10400	COG0702	epimerase
HC658_10440	COG0189	ligase activity
HC658_10450	COG0189	ligase activity
HC658_10460	COG4399	Belongs to the UPF0754 family
HC658_10470	COG3679	Belongs to the UPF0342 family
HC658_10480	COG4335	DNA alkylation repair
HC658_10490	COG0561	phosphatase activity
HC658_10500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC658_10510	COG0475	glutathione-regulated potassium exporter activity
HC658_10520	COG0490	domain, Protein
HC658_10540	COG1024	Enoyl-CoA hydratase
HC658_10560	COG4152	abc transporter atp-binding protein
HC658_10570	COG1668	transmembrane transport
HC658_10580	COG0420	3'-5' exonuclease activity
HC658_10590	COG4717	serine-type aminopeptidase activity
HC658_10600	COG3481	metal-dependent phosphohydrolase, HD sub domain
HC658_10620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC658_10660	COG1846	Transcriptional regulator
HC658_10670	COG4980	gas vesicle protein
HC658_10700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HC658_10710	COG0537	adenosine 5'-monophosphoramidase activity
HC658_10720	COG1131	(ABC) transporter
HC658_10730	COG4473	ABC transporter
HC658_10750	COG1473	amidohydrolase
HC658_10760	COG3069	C4-dicarboxylate transmembrane transporter activity
HC658_10770	COG2329	Antibiotic biosynthesis monooxygenase
HC658_10780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC658_10790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HC658_10820	COG1309	transcriptional regulator
HC658_10830	COG1511	domain protein
HC658_10840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC658_10850	COG4377	Putative membrane peptidase family (DUF2324)
HC658_10870	COG1363	Peptidase, m42
HC658_10880	COG4405	Protein conserved in bacteria
HC658_10890	COG1301	dicarboxylic acid transport
HC658_10910	COG1234	tRNA 3'-trailer cleavage
HC658_10920	COG0095	Lipoate-protein ligase
HC658_10930	COG0702	epimerase
HC658_10940	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_10960	COG0501	Belongs to the peptidase M48B family
HC658_10990	COG0456	acetyltransferase
HC658_11000	COG0604	alcohol dehydrogenase
HC658_11010	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC658_11020	COG0406	alpha-ribazole phosphatase activity
HC658_11030	COG0183	Belongs to the thiolase family
HC658_11040	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_11050	COG1268	BioY protein
HC658_11060	COG0840	transmembrane signaling receptor activity
HC658_11070	COG0723	plastoquinol--plastocyanin reductase activity
HC658_11070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC658_11080	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_11100	COG4903	ComK protein
HC658_11110	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_11130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_11160	COG0398	Pfam SNARE associated Golgi protein
HC658_11170	COG0681	Belongs to the peptidase S26 family
HC658_11180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC658_11190	COG1846	Transcriptional regulator
HC658_11200	COG0738	Major facilitator superfamily
HC658_11210	COG0673	inositol 2-dehydrogenase activity
HC658_11220	COG0561	phosphatase activity
HC658_11230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC658_11240	COG1609	Transcriptional regulator
HC658_11250	COG3180	Ammonia monooxygenase
HC658_11260	COG2814	Major facilitator Superfamily
HC658_11260	COG0477	Major facilitator Superfamily
HC658_11270	COG4533	DNA binding
HC658_11290	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HC658_11300	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HC658_11310	COG1074	ATP-dependent DNA helicase activity
HC658_11320	COG0420	3'-5' exonuclease activity
HC658_11330	COG0419	ATPase involved in DNA repair
HC658_11340	COG1403	HNH endonuclease
HC658_11420	COG5337	Spore coat protein CotH
HC658_11430	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC658_11450	COG1404	Belongs to the peptidase S8 family
HC658_11470	COG0367	asparagine synthase
HC658_11480	COG2318	DinB family
HC658_11490	COG1562	ergosterol biosynthetic process
HC658_11500	COG0534	Mate efflux family protein
HC658_11510	COG1917	Cupin 2, conserved barrel domain protein
HC658_11510	COG2207	Transcriptional regulator
HC658_11520	COG1609	Transcriptional regulator
HC658_11530	COG0673	inositol 2-dehydrogenase activity
HC658_11540	COG2318	DinB family
HC658_11550	COG1279	arginine transmembrane transporter activity
HC658_11560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_11570	COG1357	PFAM Pentapeptide repeats (8 copies)
HC658_11580	COG2267	carboxylic ester hydrolase activity
HC658_11590	COG0529	Catalyzes the synthesis of activated sulfate
HC658_11600	COG2046	Belongs to the sulfate adenylyltransferase family
HC658_11610	COG0175	sulfate reduction
HC658_11620	COG2045	Belongs to the ComB family
HC658_11630	COG1809	phosphosulfolactate synthase activity
HC658_11640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_11650	COG4948	Mandelate Racemase Muconate Lactonizing
HC658_11660	COG2814	Major facilitator Superfamily
HC658_11670	COG0454	-acetyltransferase
HC658_11680	COG2153	protein acetylation
HC658_11690	COG0646	methionine synthase
HC658_11690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HC658_11700	COG1666	GTP binding
HC658_11710	COG2996	Protein conserved in bacteria
HC658_11750	COG1695	Transcriptional regulator
HC658_11780	COG3227	Zinc metalloprotease (Elastase)
HC658_11790	COG1307	EDD domain protein, DegV family
HC658_11800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_11830	COG0561	phosphatase activity
HC658_11840	COG1073	alpha beta
HC658_11850	COG2151	metal-sulfur cluster biosynthetic enzyme
HC658_11870	COG0277	FAD linked oxidase domain protein
HC658_11880	COG2271	Major facilitator Superfamily
HC658_11890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC658_11900	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HC658_11920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC658_11930	COG0505	Belongs to the CarA family
HC658_11940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC658_11950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HC658_11980	COG2267	carboxylic ester hydrolase activity
HC658_12000	COG1744	ABC transporter substrate-binding protein PnrA-like
HC658_12030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC658_12040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC658_12050	COG5504	Zn-dependent protease
HC658_12060	COG0444	Belongs to the ABC transporter superfamily
HC658_12070	COG4608	Belongs to the ABC transporter superfamily
HC658_12090	COG0601	transmembrane transport
HC658_12100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC658_12120	COG0180	Tryptophanyl-tRNA synthetase
HC658_12130	COG4166	transmembrane transport
HC658_12140	COG0601	transmembrane transport
HC658_12150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC658_12160	COG0444	Belongs to the ABC transporter superfamily
HC658_12170	COG4608	Belongs to the ABC transporter superfamily
HC658_12180	COG2814	Major facilitator Superfamily
HC658_12190	COG0456	acetyltransferase
HC658_12200	COG1393	Belongs to the ArsC family
HC658_12210	COG0861	Integral membrane protein TerC family
HC658_12220	COG4862	establishment of competence for transformation
HC658_12230	COG4469	Competence protein
HC658_12240	COG1164	Oligoendopeptidase f
HC658_12280	COG2346	COG2346, Truncated hemoglobins
HC658_12290	COG0741	lytic transglycosylase activity
HC658_12300	COG4116	CYTH
HC658_12320	COG2357	RelA SpoT domain protein
HC658_12330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC658_12340	COG0564	pseudouridine synthase activity
HC658_12350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC658_12360	COG0475	glutathione-regulated potassium exporter activity
HC658_12360	COG0569	domain protein
HC658_12370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HC658_12380	COG0352	thiamine-phosphate diphosphorylase activity
HC658_12390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC658_12400	COG2104	thiamine diphosphate biosynthetic process
HC658_12410	COG2022	thiamine diphosphate biosynthetic process
HC658_12420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC658_12430	COG0351	phosphomethylpyrimidine kinase
HC658_12440	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC658_12550	COG0210	DNA helicase
HC658_12570	COG2153	protein acetylation
HC658_12580	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC658_12590	COG2382	esterase
HC658_12600	COG0626	cystathionine gamma-synthase activity
HC658_12610	COG0626	cystathionine gamma-synthase activity
HC658_12620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_12630	COG5505	Protein of unknown function (DUF819)
HC658_12670	COG5444	nuclease activity
HC658_12720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC658_12730	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_12750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_12750	COG3711	transcriptional antiterminator
HC658_12760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_12760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC658_12760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC658_12770	COG1482	cell wall glycoprotein biosynthetic process
HC658_12790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_12810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC658_12840	COG0109	protoheme IX farnesyltransferase activity
HC658_12860	COG0726	polysaccharide deacetylase
HC658_12890	COG5504	Zn-dependent protease
HC658_12900	COG2205	protein histidine kinase activity
HC658_12920	COG3383	formate dehydrogenase (NAD+) activity
HC658_12930	COG2427	Protein of unknown function (DUF1641)
HC658_12950	COG1051	belongs to the nudix hydrolase family
HC658_12970	COG2124	cytochrome p450
HC658_12980	COG1819	glycosyl
HC658_13000	COG1587	Uroporphyrinogen-III synthase
HC658_13010	COG0390	transport system, permease component
HC658_13020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC658_13030	COG0697	spore germination
HC658_13040	COG4297	protein containing double-stranded beta helix domain
HC658_13060	COG1252	NADH dehydrogenase
HC658_13070	COG1904	glucuronate isomerase
HC658_13080	COG2211	Major facilitator Superfamily
HC658_13090	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HC658_13100	COG1063	alcohol dehydrogenase
HC658_13110	COG1312	Catalyzes the dehydration of D-mannonate
HC658_13120	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_13130	COG2271	Major facilitator Superfamily
HC658_13140	COG1609	Transcriptional regulator
HC658_13150	COG0246	Mannitol dehydrogenase
HC658_13160	COG2721	sulfolactate sulfo-lyase activity
HC658_13170	COG0730	response to heat
HC658_13180	COG2318	DinB family
HC658_13190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC658_13200	COG0457	Tetratricopeptide repeat
HC658_13220	COG2350	Protein conserved in bacteria
HC658_13230	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC658_13230	COG3409	Peptidoglycan-binding domain 1 protein
HC658_13230	COG1388	LysM domain
HC658_13250	COG4195	phage-related replication protein
HC658_13260	COG3546	catalase activity
HC658_13270	COG2856	Zn peptidase
HC658_13280	COG1396	sequence-specific DNA binding
HC658_13300	COG1522	sequence-specific DNA binding
HC658_13310	COG1484	DNA-dependent DNA replication
HC658_13350	COG1595	DNA-templated transcription, initiation
HC658_13360	COG3728	DNA packaging
HC658_13360	COG5484	DNA packaging
HC658_13370	COG1783	phage Terminase large subunit
HC658_13380	COG5518	Phage portal protein
HC658_13390	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC658_13400	COG4653	Phage capsid family
HC658_13490	COG5412	phage tail tape measure protein
HC658_13490	COG3953	SLT domain
HC658_13500	COG1652	LysM domain
HC658_13510	COG4193	domain, Protein
HC658_13530	COG3628	GPW Gp25 family protein
HC658_13540	COG3299	homolog of phage Mu protein gp47
HC658_13550	COG3778	Protein conserved in bacteria
HC658_13630	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC658_13630	COG3409	Peptidoglycan-binding domain 1 protein
HC658_13670	COG0306	phosphate transporter
HC658_13680	COG1392	Phosphate transport regulator
HC658_13690	COG0531	amino acid
HC658_13700	COG0346	lactoylglutathione lyase activity
HC658_13710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC658_13720	COG0463	Glycosyl transferase, family 2
HC658_13730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC658_13740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC658_13750	COG2362	D-Aminopeptidase
HC658_13760	COG0601	transmembrane transport
HC658_13770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC658_13780	COG0444	Belongs to the ABC transporter superfamily
HC658_13790	COG4166	transmembrane transport
HC658_13800	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC658_13810	COG4948	Mandelate Racemase Muconate Lactonizing
HC658_13820	COG0791	NLP P60 protein
HC658_13830	COG4608	Belongs to the ABC transporter superfamily
HC658_13840	COG2706	6-phosphogluconolactonase activity
HC658_13850	COG1834	amidinotransferase
HC658_13860	COG1607	acyl-coa hydrolase
HC658_13870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC658_13870	COG1017	nitric oxide dioxygenase activity
HC658_13890	COG2323	membrane
HC658_13900	COG2318	DinB family
HC658_13910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_13920	COG2076	Multidrug Resistance protein
HC658_13930	COG2076	Multidrug Resistance protein
HC658_13940	COG0788	formyltetrahydrofolate deformylase activity
HC658_13950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC658_13960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HC658_13970	COG1764	response to oxidative stress
HC658_13980	COG1846	Transcriptional regulator
HC658_13990	COG1764	response to oxidative stress
HC658_14010	COG0590	tRNA wobble adenosine to inosine editing
HC658_14020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC658_14030	COG1404	Belongs to the peptidase S8 family
HC658_14040	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_14050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC658_14060	COG1122	ATPase activity
HC658_14070	COG4721	ABC-type cobalt transport system, permease component
HC658_14090	COG0745	RESPONSE REGULATOR receiver
HC658_14100	COG3850	Histidine kinase
HC658_14100	COG5002	protein histidine kinase activity
HC658_14110	COG3212	peptidase
HC658_14120	COG3212	peptidase
HC658_14140	COG2239	Acts as a magnesium transporter
HC658_14150	COG0789	Transcriptional regulator
HC658_14180	COG1846	Transcriptional regulator
HC658_14190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC658_14200	COG0726	polysaccharide deacetylase
HC658_14210	COG1408	metallophosphoesterase
HC658_14230	COG0463	Glycosyl transferase, family 2
HC658_14240	COG3285	dna ligase
HC658_14240	COG1793	dna ligase
HC658_14250	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HC658_14260	COG3300	MHYT domain
HC658_14260	COG5001	Diguanylate cyclase
HC658_14270	COG0586	Pfam SNARE associated Golgi protein
HC658_14280	COG0861	Integral membrane protein TerC family
HC658_14290	COG1191	sigma factor activity
HC658_14330	COG0501	Belongs to the peptidase M48B family
HC658_14340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC658_14370	COG3594	Acyltransferase
HC658_14380	COG5002	protein histidine kinase activity
HC658_14390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC658_14400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HC658_14410	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HC658_14420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC658_14430	COG0436	Aminotransferase
HC658_14440	COG1850	ribulose-bisphosphate carboxylase activity
HC658_14450	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HC658_14460	COG0235	Class ii aldolase
HC658_14470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HC658_14480	COG3339	Conserved Protein
HC658_14510	COG3852	Histidine kinase
HC658_14520	COG1846	Transcriptional regulator
HC658_14530	COG1360	Flagellar Motor Protein
HC658_14540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC658_14550	COG0542	response to heat
HC658_14560	COG3949	Membrane
HC658_14570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HC658_14580	COG0720	synthase
HC658_14590	COG0602	queuosine metabolic process
HC658_14600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HC658_14610	COG1733	regulation of RNA biosynthetic process
HC658_14620	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_14630	COG4641	Protein conserved in bacteria
HC658_14630	COG1388	LysM domain
HC658_14640	COG1388	LysM domain
HC658_14650	COG3858	chitin binding
HC658_14670	COG4873	Protein conserved in bacteria
HC658_14690	COG3773	Cell wall hydrolase
HC658_14700	COG2244	polysaccharide biosynthetic process
HC658_14710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_14720	COG2217	Heavy metal translocating P-type atpase
HC658_14740	COG0006	proline dipeptidase activity
HC658_14750	COG1609	Transcriptional regulator
HC658_14760	COG3711	transcriptional antiterminator
HC658_14770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_14770	COG1263	PTS System
HC658_14770	COG2190	(PTS) system
HC658_14780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_14790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC658_14810	COG1533	DNA photolyase activity
HC658_14820	COG0456	acetyltransferase
HC658_14830	COG0840	transmembrane signaling receptor activity
HC658_14840	COG2084	Dehydrogenase
HC658_14850	COG2340	Cysteine-rich secretory protein family
HC658_14860	COG0768	penicillin binding
HC658_14870	COG4191	Histidine kinase
HC658_14880	COG0436	Aminotransferase
HC658_14900	COG0835	chemotaxis
HC658_14900	COG0784	Response regulator, receiver
HC658_14920	COG2814	Major facilitator Superfamily
HC658_14930	COG1376	ErfK ybiS ycfS ynhG family protein
HC658_14940	COG1408	metallophosphoesterase
HC658_14950	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_14960	COG2200	EAL domain
HC658_14990	COG4703	Protein of unknown function (DUF1797)
HC658_15000	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HC658_15020	COG0517	IMP dehydrogenase activity
HC658_15030	COG0583	DNA-binding transcription factor activity
HC658_15040	COG0716	FMN binding
HC658_15060	COG0716	FMN binding
HC658_15070	COG2171	N-acyltransferase activity
HC658_15080	COG1473	amidohydrolase
HC658_15100	COG0668	transmembrane transport
HC658_15110	COG0450	alkyl hydroperoxide reductase
HC658_15120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_15150	COG0746	molybdenum cofactor guanylyltransferase activity
HC658_15160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC658_15170	COG0303	'Molybdopterin
HC658_15180	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC658_15190	COG0314	molybdopterin synthase activity
HC658_15200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HC658_15210	COG1132	(ABC) transporter
HC658_15220	COG1132	(ABC) transporter
HC658_15240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC658_15250	COG1136	(ABC) transporter
HC658_15260	COG0577	efflux transmembrane transporter activity
HC658_15270	COG1349	DNA-binding transcription factor activity
HC658_15280	COG1105	Belongs to the carbohydrate kinase PfkB family
HC658_15290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_15290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC658_15290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC658_15300	COG0681	Belongs to the peptidase S26 family
HC658_15320	COG0488	(ABC) transporter
HC658_15330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC658_15340	COG2309	aminopeptidase activity
HC658_15350	COG1077	Cell shape determining protein MreB Mrl
HC658_15360	COG2002	toxin-antitoxin pair type II binding
HC658_15370	COG3852	Histidine kinase
HC658_15380	COG2105	PFAM AIG2 family protein
HC658_15380	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HC658_15390	COG0569	domain protein
HC658_15400	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC658_15410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC658_15430	COG0561	phosphatase activity
HC658_15440	COG0242	peptide deformylase activity
HC658_15450	COG0497	DNA recombination
HC658_15460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC658_15470	COG0022	dehydrogenase e1 component
HC658_15480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC658_15490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC658_15500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_15540	COG1982	Orn Lys Arg decarboxylase major
HC658_15550	COG4476	Belongs to the UPF0223 family
HC658_15560	COG4493	Belongs to the UPF0637 family
HC658_15580	COG0483	inositol monophosphate 1-phosphatase activity
HC658_15600	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HC658_15640	COG1595	DNA-templated transcription, initiation
HC658_15700	COG4896	Protein conserved in bacteria
HC658_15720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HC658_15730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC658_15740	COG2066	Belongs to the glutaminase family
HC658_15750	COG4838	Belongs to the UPF0358 family
HC658_15760	COG0772	Belongs to the SEDS family
HC658_15770	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HC658_15780	COG1612	heme a metabolic process
HC658_15790	COG0109	protoheme IX farnesyltransferase activity
HC658_15800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC658_15800	COG2010	Cytochrome c
HC658_15810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC658_15820	COG1845	cytochrome c oxidase, subunit III
HC658_15830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC658_15840	COG3336	cytochrome c oxidase
HC658_15860	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HC658_15870	COG2340	Cysteine-rich secretory protein family
HC658_15900	COG3679	Belongs to the UPF0342 family
HC658_15910	COG4471	UPF0298 protein
HC658_15930	COG0742	ribosomal rna small subunit methyltransferase
HC658_15940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC658_15950	COG3314	Sporulation integral membrane protein YlbJ
HC658_15960	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC658_15970	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC658_15980	COG1323	Belongs to the UPF0348 family
HC658_16000	COG1399	metal-binding, possibly nucleic acid-binding protein
HC658_16030	COG0454	-acetyltransferase
HC658_16040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC658_16050	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HC658_16060	COG2001	Belongs to the MraZ family
HC658_16070	COG0275	rRNA processing
HC658_16080	COG4839	cell division protein FtsL
HC658_16100	COG0768	penicillin binding
HC658_16110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC658_16120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC658_16130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC658_16140	COG0772	Belongs to the SEDS family
HC658_16150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC658_16160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC658_16170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HC658_16180	COG3879	Bacterial protein of unknown function (DUF881)
HC658_16190	COG3879	Bacterial protein of unknown function (DUF881)
HC658_16200	COG3856	small basic protein
HC658_16210	COG0849	cell division
HC658_16220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC658_16230	COG4412	M6 family metalloprotease domain protein
HC658_16230	COG1404	Belongs to the peptidase S8 family
HC658_16250	COG1191	sigma factor activity
HC658_16260	COG1191	sigma factor activity
HC658_16270	COG1119	ATPase activity
HC658_16280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC658_16290	COG1873	PFAM PRC-barrel domain
HC658_16310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC658_16320	COG1799	cell septum assembly
HC658_16330	COG0762	integral membrane protein
HC658_16340	COG2302	S4 RNA-binding domain
HC658_16350	COG3599	regulation of cell shape
HC658_16360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC658_16370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC658_16380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC658_16390	COG0564	pseudouridine synthase activity
HC658_16400	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HC658_16410	COG2233	PERMEase
HC658_16420	COG0540	Belongs to the ATCase OTCase family
HC658_16430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC658_16440	COG0505	Belongs to the CarA family
HC658_16450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC658_16460	COG0543	2 iron, 2 sulfur cluster binding
HC658_16470	COG0167	dihydroorotate dehydrogenase activity
HC658_16480	COG0284	orotidine-5'-phosphate decarboxylase activity
HC658_16490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC658_16500	COG0175	sulfate reduction
HC658_16510	COG0306	phosphate transporter
HC658_16520	COG2046	Belongs to the sulfate adenylyltransferase family
HC658_16530	COG0529	Catalyzes the synthesis of activated sulfate
HC658_16540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC658_16550	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HC658_16560	COG1648	precorrin-2 dehydrogenase activity
HC658_16570	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HC658_16580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC658_16590	COG1561	YicC-like family, N-terminal region
HC658_16610	COG0194	GDP metabolic process
HC658_16620	COG1758	RNA polymerase activity
HC658_16630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC658_16640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC658_16650	COG0242	peptide deformylase activity
HC658_16660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC658_16670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC658_16670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HC658_16680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC658_16690	COG0631	protein serine/threonine phosphatase activity
HC658_16700	COG0515	serine threonine protein kinase
HC658_16700	COG2815	serine threonine protein kinase
HC658_16710	COG1162	GTPase activity
HC658_16720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC658_16730	COG1564	THIamine pyrophosphokinase
HC658_16740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC658_16750	COG1302	Protein conserved in bacteria
HC658_16760	COG1461	Dihydroxyacetone kinase
HC658_16770	COG1760	l-serine dehydratase
HC658_16780	COG1760	l-serine dehydratase
HC658_16790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC658_16800	COG1349	DNA-binding transcription factor activity
HC658_16800	COG2050	protein possibly involved in aromatic compounds catabolism
HC658_16810	COG0416	fatty acid biosynthetic process
HC658_16820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC658_16830	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_16850	COG0571	ribonuclease III activity
HC658_16860	COG1196	nuclear chromosome segregation
HC658_16870	COG0552	protein localization to endoplasmic reticulum
HC658_16890	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HC658_16900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC658_16910	COG0228	four-way junction DNA binding
HC658_16920	COG1837	Belongs to the UPF0109 family
HC658_16940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC658_16950	COG0336	Belongs to the RNA methyltransferase TrmD family
HC658_16960	COG0335	large ribosomal subunit rRNA binding
HC658_16970	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC658_16980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC658_17000	COG2257	FlhB HrpN YscU SpaS Family
HC658_17010	COG0045	succinate-CoA ligase (ADP-forming) activity
HC658_17020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC658_17030	COG0758	DNA mediated transformation
HC658_17040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC658_17050	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HC658_17060	COG4974	Belongs to the 'phage' integrase family
HC658_17070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HC658_17080	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HC658_17090	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC658_17100	COG1815	bacterial-type flagellum-dependent cell motility
HC658_17110	COG1558	bacterial-type flagellum-dependent cell motility
HC658_17120	COG1677	Flagellar hook-basal body complex protein FliE
HC658_17130	COG1766	The M ring may be actively involved in energy transduction
HC658_17140	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC658_17150	COG1317	bacterial-type flagellum organization
HC658_17160	COG1157	protein secretion by the type III secretion system
HC658_17170	COG2882	bacterial-type flagellum organization
HC658_17180	COG3334	PFAM MgtE intracellular
HC658_17190	COG3144	bacterial-type flagellum assembly
HC658_17200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HC658_17210	COG4786	Flagellar basal body rod
HC658_17220	COG1582	Flagellar protein (FlbD)
HC658_17230	COG1580	Controls the rotational direction of flagella during chemotaxis
HC658_17240	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC658_17250	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC658_17250	COG1776	CheC inhibitor of MCP methylation
HC658_17260	COG2201	protein-glutamate methylesterase activity
HC658_17270	COG3190	flagellar
HC658_17280	COG1338	Plays a role in the flagellum-specific transport system
HC658_17290	COG1987	bacterial-type flagellum assembly
HC658_17300	COG1684	flagellar biosynthetic protein fliR
HC658_17310	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC658_17320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC658_17330	COG1419	protein localization to endoplasmic reticulum
HC658_17340	COG0455	bacterial-type flagellum organization
HC658_17350	COG2201	protein-glutamate methylesterase activity
HC658_17360	COG0643	Histidine kinase
HC658_17360	COG2198	Histidine kinase
HC658_17370	COG0835	chemotaxis
HC658_17380	COG1776	CheC inhibitor of MCP methylation
HC658_17390	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HC658_17400	COG1191	sigma factor activity
HC658_17420	COG0052	Belongs to the universal ribosomal protein uS2 family
HC658_17430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC658_17440	COG0528	UMP kinase activity
HC658_17450	COG0233	cytoplasmic translational termination
HC658_17460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC658_17470	COG4589	Belongs to the CDS family
HC658_17480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC658_17490	COG0750	zinc metalloprotease
HC658_17500	COG0442	prolyl-tRNA aminoacylation
HC658_17510	COG2176	DNA-directed DNA polymerase activity
HC658_17530	COG0779	Required for maturation of 30S ribosomal subunits
HC658_17540	COG0195	Participates in both transcription termination and antitermination
HC658_17550	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HC658_17560	COG1358	cellular component organization or biogenesis
HC658_17570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HC658_17580	COG1550	Protein conserved in bacteria
HC658_17590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC658_17600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC658_17610	COG0196	riboflavin kinase activity
HC658_17620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HC658_17630	COG1185	polyribonucleotide nucleotidyltransferase activity
HC658_17640	COG0726	polysaccharide deacetylase
HC658_17650	COG0612	Peptidase, M16
HC658_17660	COG1873	PFAM PRC-barrel domain
HC658_17670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC658_17680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC658_17690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC658_17700	COG0527	aspartate kinase activity
HC658_17710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC658_17720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC658_17730	COG0740	serine-type endopeptidase activity
HC658_17750	COG4980	gas vesicle protein
HC658_17750	COG1674	ftsk spoiiie
HC658_17760	COG2188	Transcriptional regulator
HC658_17770	COG2814	Major facilitator Superfamily
HC658_17780	COG0612	Peptidase, M16
HC658_17790	COG0612	Peptidase, M16
HC658_17800	COG0300	oxidoreductase activity
HC658_17830	COG1426	Protein conserved in bacteria
HC658_17840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC658_17850	COG1058	Belongs to the CinA family
HC658_17850	COG1546	Belongs to the CinA family
HC658_17860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HC658_17870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC658_17880	COG1418	mRNA catabolic process
HC658_17890	COG1692	metallophosphoesterase
HC658_17900	COG2359	stage V sporulation protein S
HC658_17910	COG1063	alcohol dehydrogenase
HC658_17920	COG0156	8-amino-7-oxononanoate synthase activity
HC658_17930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC658_17940	COG4550	Control of competence regulator ComK, YlbF/YmcA
HC658_17960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC658_17970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HC658_18000	COG3226	Transcriptional regulator
HC658_18010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_18020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC658_18030	COG3321	synthase
HC658_18040	COG2070	2-Nitropropane dioxygenase
HC658_18040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC658_18050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_18060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC658_18070	COG3425	synthase
HC658_18080	COG1024	Enoyl-CoA hydratase
HC658_18090	COG1024	Enoyl-CoA hydratase
HC658_18100	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_18100	COG0300	oxidoreductase activity
HC658_18100	COG3321	synthase
HC658_18100	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_18100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_18110	COG3321	synthase
HC658_18110	COG0300	oxidoreductase activity
HC658_18110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_18110	COG4221	oxidoreductase activity
HC658_18120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_18120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC658_18120	COG3321	synthase
HC658_18120	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_18120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_18130	COG4221	oxidoreductase activity
HC658_18130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_18130	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_18130	COG3321	synthase
HC658_18140	COG3321	synthase
HC658_18140	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC658_18140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC658_18140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_18150	COG2124	cytochrome p450
HC658_18170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_18180	COG1404	Belongs to the peptidase S8 family
HC658_18200	COG4195	phage-related replication protein
HC658_18210	COG1764	response to oxidative stress
HC658_18220	COG2076	Multidrug Resistance protein
HC658_18230	COG2076	Multidrug Resistance protein
HC658_18260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC658_18270	COG1923	regulation of RNA biosynthetic process
HC658_18300	COG1780	Probably involved in ribonucleotide reductase function
HC658_18310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC658_18320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC658_18330	COG4112	unkown
HC658_18340	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_18360	COG0464	growth
HC658_18370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC658_18380	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HC658_18390	COG0789	Transcriptional regulator
HC658_18400	COG0174	glutamine synthetase
HC658_18430	COG4282	regulation of fungal-type cell wall biogenesis
HC658_18450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_18500	COG0135	phosphoribosylanthranilate isomerase activity
HC658_18510	COG2211	Major facilitator Superfamily
HC658_18520	COG3507	Belongs to the glycosyl hydrolase 43 family
HC658_18530	COG1940	carbohydrate kinase activity
HC658_18540	COG2115	Belongs to the xylose isomerase family
HC658_18550	COG1070	Carbohydrate kinase
HC658_18570	COG1525	nuclease
HC658_18580	COG2814	Major facilitator Superfamily
HC658_18590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC658_18610	COG0756	dUTP diphosphatase activity
HC658_18680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC658_18700	COG3832	glyoxalase III activity
HC658_18720	COG0697	spore germination
HC658_18730	COG0531	amino acid
HC658_18800	COG4195	phage-related replication protein
HC658_18820	COG0346	lactoylglutathione lyase activity
HC658_18850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC658_18860	COG1388	LysM domain
HC658_18870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC658_18880	COG4224	UPF0291 protein
HC658_18890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC658_18910	COG3763	UPF0154 protein
HC658_18930	COG0785	Cytochrome C biogenesis protein
HC658_18940	COG2201	protein-glutamate methylesterase activity
HC658_18950	COG4846	Membrane protein involved in cytochrome C biogenesis
HC658_18970	COG0071	Belongs to the small heat shock protein (HSP20) family
HC658_19000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC658_19010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_19050	COG0824	Thioesterase
HC658_19070	COG4841	protein insertion into membrane
HC658_19080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HC658_19090	COG1832	CoA-binding protein
HC658_19100	COG0187	DNA topoisomerase II activity
HC658_19110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC658_19140	COG1115	amino acid carrier protein
HC658_19150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HC658_19170	COG5520	Belongs to the glycosyl hydrolase 30 family
HC658_19180	COG3507	Belongs to the glycosyl hydrolase 43 family
HC658_19190	COG2246	polysaccharide biosynthetic process
HC658_19200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC658_19210	COG0586	Pfam SNARE associated Golgi protein
HC658_19220	COG2404	hydrolase activity, acting on ester bonds
HC658_19230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC658_19240	COG1024	Enoyl-CoA hydratase
HC658_19250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC658_19260	COG0511	ligase activity, forming carbon-carbon bonds
HC658_19270	COG0439	Biotin carboxylase
HC658_19280	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_19290	COG1960	acyl-CoA dehydrogenase activity
HC658_19310	COG1649	PFAM Uncharacterised BCR, COG1649
HC658_19330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_19330	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC658_19340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_19350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_19360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_19370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_19380	COG2027	D-alanyl-D-alanine carboxypeptidase
HC658_19390	COG2017	converts alpha-aldose to the beta-anomer
HC658_19400	COG0534	Mate efflux family protein
HC658_19430	COG0582	viral genome integration into host DNA
HC658_19440	COG0166	Belongs to the GPI family
HC658_19450	COG0405	Gamma-glutamyltransferase
HC658_19460	COG0583	DNA-binding transcription factor activity
HC658_19470	COG0604	alcohol dehydrogenase
HC658_19480	COG0493	'glutamate synthase
HC658_19490	COG0069	glutamate synthase activity
HC658_19490	COG0067	glutamate synthase
HC658_19490	COG0070	glutamate synthase
HC658_19500	COG0583	DNA-binding transcription factor activity
HC658_19510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC658_19520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC658_19540	COG0300	oxidoreductase activity
HC658_19550	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC658_19570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_19580	COG2814	Major facilitator Superfamily
HC658_19590	COG1070	Carbohydrate kinase
HC658_19600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC658_19610	COG0243	molybdopterin cofactor binding
HC658_19660	COG0840	transmembrane signaling receptor activity
HC658_19660	COG5278	phosphoserine phosphatase activity
HC658_19670	COG2368	4-hydroxyphenylacetate
HC658_19680	COG4305	rare lipoprotein A
HC658_19690	COG3619	membrane
HC658_19700	COG3866	Pectate lyase
HC658_19710	COG2135	peptidase activity
HC658_19730	COG2140	Oxalate decarboxylase
HC658_19750	COG0456	acetyltransferase
HC658_19770	COG2720	vancomycin resistance protein
HC658_19790	COG3655	Transcriptional regulator
HC658_19800	COG3739	integral membrane protein
HC658_19810	COG0583	DNA-binding transcription factor activity
HC658_19820	COG0697	spore germination
HC658_19840	COG0693	protein deglycase activity
HC658_19850	COG2367	Beta-lactamase
HC658_19880	COG0574	Belongs to the PEP-utilizing enzyme family
HC658_19880	COG3848	Pyruvate phosphate dikinase
HC658_19900	COG0726	polysaccharide deacetylase
HC658_19910	COG2314	TM2 domain
HC658_19920	COG1396	sequence-specific DNA binding
HC658_19950	COG2135	peptidase activity
HC658_20000	COG0457	Tetratricopeptide repeat
HC658_20020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC658_20030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC658_20060	COG5290	Psort location Cytoplasmic, score
HC658_20110	COG5444	nuclease activity
HC658_20120	COG4282	regulation of fungal-type cell wall biogenesis
HC658_20130	COG1231	oxidoreductase activity
HC658_20140	COG5434	Belongs to the glycosyl hydrolase 28 family
HC658_20160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_20170	COG0662	Cupin 2, conserved barrel domain protein
HC658_20170	COG2207	Transcriptional regulator
HC658_20180	COG0456	acetyltransferase
HC658_20190	COG1309	transcriptional regulator
HC658_20200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_20210	COG3708	Transcriptional regulator
HC658_20220	COG2378	regulation of single-species biofilm formation
HC658_20240	COG0640	Transcriptional regulator
HC658_20250	COG0741	lytic transglycosylase activity
HC658_20260	COG2322	membrane
HC658_20290	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC658_20300	COG3239	Fatty acid desaturase
HC658_20310	COG4585	Histidine kinase
HC658_20320	COG2197	response regulator
HC658_20330	COG1388	LysM domain
HC658_20330	COG3584	3D domain protein
HC658_20340	COG0514	ATP-dependent DNA helicase (RecQ)
HC658_20370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC658_20380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC658_20410	COG0071	Belongs to the small heat shock protein (HSP20) family
HC658_20460	COG1012	belongs to the aldehyde dehydrogenase family
HC658_20470	COG1657	PFAM Prenyltransferase squalene oxidase
HC658_20480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC658_20490	COG0733	neurotransmitter:sodium symporter activity
HC658_20500	COG0385	Bile acid
HC658_20510	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC658_20520	COG0567	Dehydrogenase, E1 component
HC658_20530	COG4548	von Willebrand factor, type A
HC658_20540	COG0714	Associated with various cellular activities
HC658_20550	COG2032	superoxide dismutase activity
HC658_20560	COG0791	NLP P60 protein
HC658_20560	COG1388	LysM domain
HC658_20570	COG1819	glycosyl
HC658_20580	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC658_20590	COG0534	Mate efflux family protein
HC658_20600	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_20610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC658_20620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC658_20640	COG2962	Rard protein
HC658_20670	COG2610	gluconate transmembrane transporter activity
HC658_20680	COG1942	4-Oxalocrotonate Tautomerase
HC658_20700	COG1733	regulation of RNA biosynthetic process
HC658_20710	COG0778	Nitroreductase
HC658_20720	COG0400	carboxylic ester hydrolase activity
HC658_20730	COG0346	lactoylglutathione lyase activity
HC658_20750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_20760	COG3409	Peptidoglycan-binding domain 1 protein
HC658_20760	COG0793	Belongs to the peptidase S41A family
HC658_20770	COG2226	methyltransferase
HC658_20790	COG1876	peptidase activity
HC658_20800	COG0813	purine-nucleoside phosphorylase activity
HC658_20830	COG0671	phosphoesterase, PA-phosphatase related
HC658_20870	COG4479	Belongs to the UPF0346 family
HC658_20890	COG1509	lysine 2,3-aminomutase activity
HC658_20900	COG0456	acetyltransferase
HC658_20910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC658_20920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC658_20930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC658_20940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC658_20960	COG0456	acetyltransferase
HC658_20970	COG0463	Glycosyl transferase, family 2
HC658_21000	COG4641	Protein conserved in bacteria
HC658_21010	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HC658_21020	COG1086	Polysaccharide biosynthesis protein
HC658_21030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC658_21040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC658_21050	COG1846	Transcriptional regulator
HC658_21060	COG0534	Mate efflux family protein
HC658_21080	COG4698	Protein conserved in bacteria
HC658_21090	COG2755	lipolytic protein G-D-S-L family
HC658_21100	COG1999	signal sequence binding
HC658_21120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC658_21130	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC658_21140	COG1272	protein, Hemolysin III
HC658_21150	COG0204	Acyl-transferase
HC658_21160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC658_21170	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HC658_21180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC658_21200	COG2521	methyltransferase
HC658_21200	COG2136	Putative SAM-dependent methyltransferase
HC658_21220	COG0129	dihydroxy-acid dehydratase activity
HC658_21230	COG1413	lyase activity
HC658_21240	COG1418	mRNA catabolic process
HC658_21250	COG0386	Belongs to the glutathione peroxidase family
HC658_21260	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HC658_21270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC658_21280	COG1278	Cold shock
HC658_21320	COG0328	RNA-DNA hybrid ribonuclease activity
HC658_21330	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HC658_21340	COG0328	RNA-DNA hybrid ribonuclease activity
HC658_21360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC658_21390	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC658_21400	COG1755	Isoprenylcysteine carboxyl methyltransferase
HC658_21410	COG3424	synthase
HC658_21420	COG2233	PERMEase
HC658_21430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC658_21440	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC658_21460	COG0800	Aldolase
HC658_21470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_21480	COG1609	Transcriptional regulator
HC658_21490	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HC658_21500	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_21510	COG1199	ATP-dependent helicase activity
HC658_21530	COG0116	Belongs to the methyltransferase superfamily
HC658_21550	COG4474	Belongs to the UPF0398 family
HC658_21560	COG3359	exonuclease
HC658_21570	COG1205	dead DEAH box helicase
HC658_21570	COG1111	helicase
HC658_21580	COG2190	(PTS) system
HC658_21590	COG0071	Belongs to the small heat shock protein (HSP20) family
HC658_21660	COG3331	DNA recombination
HC658_21670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC658_21670	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC658_21690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC658_21700	COG3935	DnaD domain protein
HC658_21710	COG0017	Asparaginyl-tRNA synthetase
HC658_21720	COG0436	Aminotransferase
HC658_21730	COG5353	protein conserved in bacteria
HC658_21750	COG1199	ATP-dependent helicase activity
HC658_21750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC658_21760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HC658_21770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HC658_21780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HC658_21790	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HC658_21790	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HC658_21800	COG0617	tRNA 3'-terminal CCA addition
HC658_21810	COG0438	transferase activity, transferring glycosyl groups
HC658_21820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC658_21830	COG1803	Methylglyoxal synthase
HC658_21840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HC658_21850	COG1694	Mazg nucleotide pyrophosphohydrolase
HC658_21860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_21880	COG4347	Protein of unknown function (DUF1405)
HC658_21890	COG2010	Cytochrome c
HC658_21890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC658_21900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC658_21910	COG0723	plastoquinol--plastocyanin reductase activity
HC658_21930	COG5582	Belongs to the UPF0302 family
HC658_21940	COG0457	Tetratricopeptide repeat
HC658_21950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC658_21960	COG0287	Prephenate dehydrogenase
HC658_21970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC658_21980	COG0159	tryptophan synthase activity
HC658_21990	COG0133	tryptophan synthase activity
HC658_22000	COG0135	phosphoribosylanthranilate isomerase activity
HC658_22020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC658_22030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC658_22040	COG4401	Chorismate mutase type I
HC658_22050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HC658_22060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC658_22070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HC658_22080	COG0105	UTP biosynthetic process
HC658_22090	COG0142	geranyltranstransferase activity
HC658_22100	COG2226	methyltransferase
HC658_22110	COG0142	geranyltranstransferase activity
HC658_22130	COG0302	gtp cyclohydrolase
HC658_22140	COG0776	regulation of translation
HC658_22150	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC658_22180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC658_22190	COG1160	GTP binding
HC658_22240	COG1304	FMN binding
HC658_22250	COG0539	negative regulation of cytoplasmic translation
HC658_22260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC658_22280	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HC658_22290	COG2959	enzyme of heme biosynthesis
HC658_22300	COG3773	Cell wall hydrolase
HC658_22300	COG3409	Peptidoglycan-binding domain 1 protein
HC658_22310	COG2339	peptidase activity
HC658_22320	COG0492	ferredoxin-NADP+ reductase activity
HC658_22330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC658_22340	COG4862	establishment of competence for transformation
HC658_22350	COG1408	metallophosphoesterase
HC658_22370	COG1388	LysM domain
HC658_22380	COG1266	CAAX protease self-immunity
HC658_22390	COG0514	ATP-dependent DNA helicase (RecQ)
HC658_22400	COG4955	Helix-turn-helix domain
HC658_22410	COG1141	Ferredoxin
HC658_22420	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HC658_22430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC658_22440	COG0710	3-dehydroquinate dehydratase activity
HC658_22460	COG1595	DNA-templated transcription, initiation
HC658_22470	COG5002	protein histidine kinase activity
HC658_22480	COG0745	RESPONSE REGULATOR receiver
HC658_22490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC658_22500	COG1333	cytochrome c biogenesis protein
HC658_22510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_22520	COG1187	pseudouridine synthase activity
HC658_22530	COG0700	Nucleoside recognition
HC658_22540	COG2715	membrane protein required for spore maturation
HC658_22550	COG1686	Belongs to the peptidase S11 family
HC658_22570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HC658_22580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HC658_22590	COG1547	Domain of unknown function (DUF309)
HC658_22600	COG0456	acetyltransferase
HC658_22610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HC658_22620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC658_22620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC658_22630	COG0307	riboflavin synthase, alpha
HC658_22640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC658_22640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC658_22660	COG0681	Belongs to the peptidase S26 family
HC658_22670	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HC658_22710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC658_22720	COG4086	secreted protein
HC658_22730	COG0019	diaminopimelate decarboxylase activity
HC658_22740	COG0697	spore germination
HC658_22770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC658_22810	COG1191	sigma factor activity
HC658_22820	COG2172	sigma factor antagonist activity
HC658_22830	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_22840	COG1686	Belongs to the peptidase S11 family
HC658_22850	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HC658_22860	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HC658_22870	COG4974	Belongs to the 'phage' integrase family
HC658_22890	COG0735	belongs to the Fur family
HC658_22900	COG1300	Membrane
HC658_22920	COG0281	malic enzyme
HC658_22930	COG1757	Na H antiporter
HC658_22940	COG1027	Aspartate ammonia-lyase
HC658_22950	COG0252	asparaginase activity
HC658_22960	COG1396	sequence-specific DNA binding
HC658_22970	COG1379	DNA repair
HC658_22980	COG0494	nUDIX hydrolase
HC658_23000	COG0667	Aldo Keto reductase
HC658_23020	COG1073	alpha beta
HC658_23040	COG4918	Iron-sulphur cluster biosynthesis
HC658_23050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC658_23050	COG0456	acetyltransferase
HC658_23060	COG2329	Antibiotic biosynthesis monooxygenase
HC658_23070	COG0456	acetyltransferase
HC658_23090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC658_23120	COG2211	Major facilitator Superfamily
HC658_23140	COG0346	lactoylglutathione lyase activity
HC658_23150	COG1072	(Pantothenic acid kinase))
HC658_23160	COG3048	D-serine ammonia-lyase activity
HC658_23170	COG0300	oxidoreductase activity
HC658_23180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_23190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC658_23200	COG4187	Peptidase family M20/M25/M40
HC658_23210	COG1902	pentaerythritol trinitrate reductase activity
HC658_23220	COG0596	Alpha beta hydrolase
HC658_23230	COG1234	tRNA 3'-trailer cleavage
HC658_23240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HC658_23250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC658_23260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC658_23280	COG0706	membrane insertase activity
HC658_23290	COG3361	conserved protein (COG2071)
HC658_23300	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC658_23310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC658_23320	COG0346	lactoylglutathione lyase activity
HC658_23330	COG1376	ErfK ybiS ycfS ynhG family protein
HC658_23340	COG4129	membrane
HC658_23350	COG1126	abc transporter atp-binding protein
HC658_23360	COG0765	amino acid transport
HC658_23370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_23390	COG1597	lipid kinase activity
HC658_23400	COG2814	Major facilitator Superfamily
HC658_23410	COG0789	Transcriptional regulator
HC658_23410	COG4978	Transcriptional regulator
HC658_23420	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC658_23430	COG0022	dehydrogenase e1 component
HC658_23440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC658_23450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC658_23460	COG3426	butyrate kinase activity
HC658_23470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC658_23480	COG0280	phosphate acetyltransferase
HC658_23490	COG3829	transcription factor binding
HC658_23490	COG3290	protein histidine kinase activity
HC658_23510	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HC658_23520	COG2079	MmgE PrpD family protein
HC658_23530	COG0372	Belongs to the citrate synthase family
HC658_23540	COG1960	acyl-CoA dehydrogenase activity
HC658_23550	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC658_23560	COG0183	Belongs to the thiolase family
HC658_23570	COG0584	glycerophosphoryl diester phosphodiesterase
HC658_23580	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_23600	COG1902	pentaerythritol trinitrate reductase activity
HC658_23610	COG0745	RESPONSE REGULATOR receiver
HC658_23630	COG0750	zinc metalloprotease
HC658_23640	COG0497	DNA recombination
HC658_23650	COG1438	arginine binding
HC658_23660	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HC658_23670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HC658_23680	COG0142	geranyltranstransferase activity
HC658_23690	COG1722	exodeoxyribonuclease VII activity
HC658_23700	COG1570	exodeoxyribonuclease VII activity
HC658_23710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HC658_23720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC658_23730	COG1302	Protein conserved in bacteria
HC658_23740	COG0439	Biotin carboxylase
HC658_23750	COG0511	ligase activity, forming carbon-carbon bonds
HC658_23830	COG3854	ATPases associated with a variety of cellular activities
HC658_23850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC658_23860	COG0006	proline dipeptidase activity
HC658_23870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HC658_23890	COG3872	metal-dependent enzyme
HC658_23910	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC658_23920	COG1321	iron dependent repressor
HC658_23930	COG0095	Lipoate-protein ligase
HC658_23940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC658_23950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC658_23960	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC658_23970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC658_23980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC658_24010	COG1396	sequence-specific DNA binding
HC658_24030	COG0681	Belongs to the peptidase S26 family
HC658_24080	COG4940	Competence protein ComGF
HC658_24100	COG4970	Tfp pilus assembly protein FimT
HC658_24110	COG4537	Required for transformation and DNA binding
HC658_24120	COG1459	type II secretion system
HC658_24130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC658_24150	COG0517	IMP dehydrogenase activity
HC658_24160	COG0598	Magnesium transport protein CorA
HC658_24170	COG1253	flavin adenine dinucleotide binding
HC658_24180	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_24200	COG1393	Belongs to the ArsC family
HC658_24220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_24240	COG0011	TIGRFAM Protein of
HC658_24260	COG2866	Carboxypeptidase
HC658_24270	COG1368	sulfuric ester hydrolase activity
HC658_24280	COG1940	carbohydrate kinase activity
HC658_24290	COG4483	Protein conserved in bacteria
HC658_24300	COG0705	Rhomboid family
HC658_24300	COG0457	Tetratricopeptide repeat
HC658_24320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC658_24340	COG0438	transferase activity, transferring glycosyl groups
HC658_24370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC658_24380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC658_24390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC658_24400	COG0581	inorganic phosphate transmembrane transporter activity
HC658_24410	COG0573	inorganic phosphate transmembrane transporter activity
HC658_24420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC658_24440	COG0477	Major facilitator Superfamily
HC658_24450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC658_24460	COG2839	Protein conserved in bacteria
HC658_24470	COG5521	maltodextrose utilization protein MalA
HC658_24490	COG1388	LysM domain
HC658_24500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HC658_24510	COG4709	membrane
HC658_24520	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HC658_24530	COG0735	belongs to the Fur family
HC658_24540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_24560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HC658_24570	COG0513	Belongs to the DEAD box helicase family
HC658_24590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HC658_24600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC658_24610	COG2384	SAM-dependent methyltransferase
HC658_24620	COG2010	Cytochrome c
HC658_24640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC658_24650	COG0358	DNA primase activity
HC658_24660	COG1671	Belongs to the UPF0178 family
HC658_24670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HC658_24680	COG0517	IMP dehydrogenase activity
HC658_24690	COG0751	glycine-tRNA ligase activity
HC658_24700	COG0752	glycyl-tRNA synthetase alpha subunit
HC658_24710	COG1381	Involved in DNA repair and RecF pathway recombination
HC658_24730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC658_24740	COG0295	cytidine deaminase activity
HC658_24750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC658_24760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC658_24770	COG1480	7TM receptor with intracellular HD hydrolase
HC658_24780	COG1702	phosphate starvation-inducible protein PhoH
HC658_24790	COG0561	phosphatase activity
HC658_24820	COG4864	UPF0365 protein
HC658_24830	COG1030	water channel activity
HC658_24840	COG1610	YqeY-like protein
HC658_24860	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC658_24870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC658_24880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC658_24890	COG2264	protein methyltransferase activity
HC658_24900	COG0484	heat shock protein binding
HC658_24920	COG0443	Heat shock 70 kDa protein
HC658_24930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC658_24940	COG1420	regulation of RNA biosynthetic process
HC658_24950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC658_24960	COG0481	GTPase activity
HC658_24980	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_24990	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HC658_25000	COG0268	Binds directly to 16S ribosomal RNA
HC658_25010	COG1466	dna polymerase III delta subunit
HC658_25020	COG0658	competence protein
HC658_25020	COG2333	competence protein COMEC
HC658_25030	COG2131	deaminase
HC658_25040	COG1596	polysaccharide export
HC658_25040	COG1555	photosystem II stabilization
HC658_25050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC658_25060	COG2226	methyltransferase
HC658_25070	COG0799	negative regulation of ribosome biogenesis
HC658_25080	COG1713	HD superfamily hydrolase involved in NAD metabolism
HC658_25090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC658_25100	COG1534	Rna-binding protein
HC658_25110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC658_25120	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC658_25130	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HC658_25150	COG2755	lipolytic protein G-D-S-L family
HC658_25160	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC658_25160	COG3409	Peptidoglycan-binding domain 1 protein
HC658_25170	COG0398	Pfam SNARE associated Golgi protein
HC658_25180	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HC658_25200	COG3209	COG3209 Rhs family protein
HC658_25210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC658_25220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC658_25230	COG0798	PFAM Bile acid sodium symporter
HC658_25240	COG0346	lactoylglutathione lyase activity
HC658_25250	COG0640	Transcriptional regulator
HC658_25260	COG3403	YqcI/YcgG family
HC658_25270	COG0457	Tetratricopeptide repeat
HC658_25300	COG5444	nuclease activity
HC658_25340	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC658_25340	COG3409	Peptidoglycan-binding domain 1 protein
HC658_25350	COG4824	toxin secretion phage lysis holin
HC658_25390	COG3778	Protein conserved in bacteria
HC658_25400	COG3299	homolog of phage Mu protein gp47
HC658_25410	COG3628	GPW Gp25 family protein
HC658_25430	COG4193	domain, Protein
HC658_25440	COG1652	LysM domain
HC658_25450	COG3953	SLT domain
HC658_25450	COG5280	Phage tail tape measure protein TP901
HC658_25590	COG4653	Phage capsid family
HC658_25600	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC658_25620	COG2369	cell adhesion
HC658_25630	COG5518	Phage portal protein
HC658_25640	COG1783	phage Terminase large subunit
HC658_25650	COG5484	DNA packaging
HC658_25670	COG3677	Transposase
HC658_25700	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HC658_25720	COG1484	DNA-dependent DNA replication
HC658_25730	COG3935	DnaD domain protein
HC658_25740	COG3723	Recombinational DNA repair protein, rece pathway
HC658_25750	COG5377	YqaJ viral recombinase family
HC658_25800	COG1476	TRANSCRIPTIONal
HC658_25810	COG3620	sequence-specific DNA binding
HC658_25820	COG0563	adenylate kinase activity
HC658_25830	COG2856	Zn peptidase
HC658_25850	COG3223	Belongs to the PsiE family
HC658_25860	COG5002	protein histidine kinase activity
HC658_25860	COG0642	Histidine kinase
HC658_25870	COG0745	RESPONSE REGULATOR receiver
HC658_25880	COG2311	Membrane
HC658_25890	COG0454	-acetyltransferase
HC658_25900	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC658_25920	COG0730	response to heat
HC658_25930	COG0425	Belongs to the sulfur carrier protein TusA family
HC658_25940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC658_25940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_25960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC658_25960	COG0425	Belongs to the sulfur carrier protein TusA family
HC658_25970	COG2210	Belongs to the sulfur carrier protein TusA family
HC658_25980	COG1937	Protein conserved in bacteria
HC658_25990	COG0662	Cupin 2, conserved barrel domain protein
HC658_26000	COG0789	Transcriptional regulator
HC658_26000	COG4978	Transcriptional regulator
HC658_26010	COG2814	Major facilitator Superfamily
HC658_26020	COG0456	acetyltransferase
HC658_26030	COG1253	flavin adenine dinucleotide binding
HC658_26050	COG0697	spore germination
HC658_26060	COG0583	DNA-binding transcription factor activity
HC658_26070	COG2072	flavoprotein involved in K transport
HC658_26080	COG1230	cation diffusion facilitator family transporter
HC658_26090	COG1942	4-Oxalocrotonate Tautomerase
HC658_26100	COG0583	DNA-binding transcription factor activity
HC658_26120	COG1114	Component of the transport system for branched-chain amino acids
HC658_26130	COG1687	branched-chain amino acid
HC658_26140	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HC658_26150	COG1522	sequence-specific DNA binding
HC658_26160	COG2732	(Barnase) inhibitor
HC658_26170	COG2124	cytochrome p450
HC658_26190	COG1335	isochorismatase
HC658_26210	COG2318	DinB family
HC658_26230	COG2070	2-Nitropropane dioxygenase
HC658_26240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC658_26270	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC658_26280	COG1595	DNA-templated transcription, initiation
HC658_26290	COG0667	Aldo Keto reductase
HC658_26300	COG2851	Citrate transporter
HC658_26310	COG0583	DNA-binding transcription factor activity
HC658_26320	COG2828	Protein conserved in bacteria
HC658_26330	COG3409	Peptidoglycan-binding domain 1 protein
HC658_26340	COG5566	PFAM Mor transcription activator
HC658_26350	COG0596	Alpha beta hydrolase
HC658_26360	COG4991	sh3 domain protein
HC658_26370	COG4991	sh3 domain protein
HC658_26380	COG0346	lactoylglutathione lyase activity
HC658_26400	COG5577	PFAM Coat F domain
HC658_26410	COG1063	alcohol dehydrogenase
HC658_26430	COG5577	PFAM Coat F domain
HC658_26440	COG0789	Transcriptional regulator
HC658_26460	COG1064	alcohol dehydrogenase
HC658_26470	COG0693	protein deglycase activity
HC658_26480	COG1621	beta-fructofuranosidase activity
HC658_26490	COG3716	PTS system mannose fructose sorbose family IID component
HC658_26500	COG3715	PTS system
HC658_26510	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_26520	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_26530	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC658_26530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC658_26540	COG1113	amino acid transport
HC658_26550	COG1280	lysine exporter protein (LysE YggA)
HC658_26560	COG1378	Sugar-specific transcriptional regulator TrmB
HC658_26570	COG1595	DNA-templated transcription, initiation
HC658_26590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HC658_26590	COG2755	lipolytic protein G-D-S-L family
HC658_26610	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC658_26610	COG2124	cytochrome p450
HC658_26620	COG1309	transcriptional regulator
HC658_26630	COG2226	methyltransferase
HC658_26660	COG2116	formate transmembrane transporter activity
HC658_26670	COG5609	conserved protein (DUF2294)
HC658_26680	COG3383	formate dehydrogenase (NAD+) activity
HC658_26690	COG2427	Protein of unknown function (DUF1641)
HC658_26710	COG0626	cystathionine gamma-synthase activity
HC658_26720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC658_26730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC658_26740	COG2226	methyltransferase
HC658_26770	COG0768	penicillin binding
HC658_26780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC658_26790	COG0572	uridine kinase
HC658_26820	COG4122	O-methyltransferase activity
HC658_26830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC658_26840	COG3906	Belongs to the UPF0473 family
HC658_26850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC658_26860	COG4472	Bacterial protein of unknown function (DUF965)
HC658_26870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC658_26880	COG0628	permease
HC658_26890	COG1126	abc transporter atp-binding protein
HC658_26900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_26910	COG0765	amino acid transport
HC658_26920	COG0765	amino acid transport
HC658_26950	COG3881	PFAM PRC-barrel domain
HC658_26960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC658_26970	COG0457	Tetratricopeptide repeat
HC658_26980	COG0482	sulfurtransferase activity
HC658_26990	COG1104	cysteine desulfurase activity
HC658_27000	COG1959	2 iron, 2 sulfur cluster binding
HC658_27010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC658_27020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HC658_27050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC658_27060	COG0124	histidyl-tRNA synthetase
HC658_27080	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_27080	COG4991	sh3 domain protein
HC658_27080	COG3103	Sh3 type 3 domain protein
HC658_27090	COG1490	D-aminoacyl-tRNA deacylase activity
HC658_27100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC658_27110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC658_27120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC658_27120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HC658_27130	COG5416	Lipopolysaccharide assembly protein A domain
HC658_27140	COG0490	domain, Protein
HC658_27150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC658_27150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC658_27170	COG2244	polysaccharide biosynthetic process
HC658_27180	COG2323	membrane
HC658_27200	COG1862	Preprotein translocase
HC658_27210	COG0343	queuine tRNA-ribosyltransferase activity
HC658_27220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HC658_27240	COG2255	four-way junction helicase activity
HC658_27250	COG0632	four-way junction helicase activity
HC658_27270	COG2814	Major facilitator Superfamily
HC658_27280	COG0673	inositol 2-dehydrogenase activity
HC658_27290	COG2112	serine threonine protein kinase
HC658_27320	COG1115	amino acid carrier protein
HC658_27330	COG0217	transcriptional regulatory protein
HC658_27350	COG1388	LysM domain
HC658_27360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC658_27370	COG0157	Belongs to the NadC ModD family
HC658_27380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC658_27390	COG1104	cysteine desulfurase activity
HC658_27400	COG1827	regulation of RNA biosynthetic process
HC658_27410	COG0077	Prephenate dehydratase
HC658_27420	COG4492	Belongs to the UPF0735 family
HC658_27430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC658_27440	COG3290	protein histidine kinase activity
HC658_27450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC658_27460	COG2868	ribosomal protein
HC658_27470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC658_27480	COG1994	Peptidase M50
HC658_27490	COG0739	heme binding
HC658_27500	COG2894	cell division
HC658_27510	COG0850	regulation of cytokinetic process
HC658_27520	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC658_27540	COG1077	Cell shape determining protein MreB Mrl
HC658_27550	COG2003	Belongs to the UPF0758 family
HC658_27560	COG0424	maF-like protein
HC658_27580	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HC658_27590	COG0285	dihydrofolate synthase activity
HC658_27600	COG0525	valine-tRNA ligase activity
HC658_27620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_27630	COG1388	LysM domain
HC658_27640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC658_27650	COG0113	porphobilinogen synthase activity
HC658_27660	COG1587	Uroporphyrinogen-III synthase
HC658_27670	COG0181	hydroxymethylbilane synthase activity
HC658_27680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC658_27690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HC658_27710	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HC658_27720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC658_27730	COG0470	DNA polymerase III
HC658_27730	COG1067	ATP-dependent peptidase activity
HC658_27740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC658_27750	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC658_27760	COG0457	Tetratricopeptide repeat
HC658_27760	COG1477	protein flavinylation
HC658_27770	COG0066	3-isopropylmalate dehydratase activity
HC658_27780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HC658_27790	COG0473	3-isopropylmalate dehydrogenase activity
HC658_27800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC658_27810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HC658_27820	COG0440	acetolactate synthase activity
HC658_27830	COG0028	Belongs to the TPP enzyme family
HC658_27850	COG0454	-acetyltransferase
HC658_27870	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HC658_27890	COG0622	Phosphoesterase
HC658_27900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC658_27910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC658_27920	COG5401	PFAM Sporulation and spore germination
HC658_27930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC658_27940	COG1846	Transcriptional regulator
HC658_27950	COG2197	response regulator
HC658_27960	COG0824	Thioesterase
HC658_27970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC658_27980	COG1053	succinate dehydrogenase
HC658_27990	COG2009	succinate dehydrogenase
HC658_28000	COG1719	4-vinyl reductase, 4VR
HC658_28010	COG0527	aspartate kinase activity
HC658_28020	COG0322	excinuclease ABC activity
HC658_28030	COG3118	belongs to the thioredoxin family
HC658_28050	COG3534	alpha-L-arabinofuranosidase
HC658_28060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HC658_28070	COG2086	electron transfer activity
HC658_28080	COG1024	Enoyl-CoA hydratase
HC658_28090	COG1309	transcriptional regulator
HC658_28100	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_28110	COG3766	membrane
HC658_28120	COG1193	negative regulation of DNA recombination
HC658_28130	COG1796	DNA polymerase
HC658_28130	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC658_28140	COG1286	toxin biosynthetic process
HC658_28150	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HC658_28160	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC658_28170	COG0072	phenylalanine-tRNA ligase activity
HC658_28170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_28180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC658_28190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC658_28210	COG3835	regulator
HC658_28220	COG0277	FAD linked oxidase domain protein
HC658_28230	COG0247	lactate metabolic process
HC658_28240	COG0346	lactoylglutathione lyase activity
HC658_28250	COG1966	Carbon starvation protein
HC658_28260	COG3534	alpha-L-arabinofuranosidase
HC658_28270	COG0395	ABC-type sugar transport system, permease component
HC658_28280	COG1175	transmembrane transport
HC658_28290	COG1653	transport
HC658_28300	COG0371	Dehydrogenase
HC658_28310	COG0647	UMP catabolic process
HC658_28320	COG0235	Class ii aldolase
HC658_28330	COG1069	ribulokinase activity
HC658_28340	COG2160	L-arabinose isomerase activity
HC658_28350	COG3507	Belongs to the glycosyl hydrolase 43 family
HC658_28360	COG1363	Peptidase, m42
HC658_28380	COG3326	Membrane
HC658_28390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC658_28400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC658_28410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC658_28430	COG1346	cytolysis
HC658_28440	COG1380	Effector of murein hydrolase LrgA
HC658_28450	COG3279	Response regulator of the LytR AlgR family
HC658_28460	COG3275	phosphorelay sensor kinase activity
HC658_28470	COG1011	Hydrolase
HC658_28480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC658_28500	COG0398	Pfam SNARE associated Golgi protein
HC658_28510	COG1484	DNA-dependent DNA replication
HC658_28520	COG3611	Membrane attachment protein
HC658_28530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC658_28540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HC658_28550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC658_28560	COG1733	regulation of RNA biosynthetic process
HC658_28570	COG2814	Major facilitator Superfamily
HC658_28580	COG0656	L-ascorbic acid biosynthetic process
HC658_28590	COG0237	dephospho-CoA kinase activity
HC658_28600	COG1971	Probably functions as a manganese efflux pump
HC658_28610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC658_28620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC658_28620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC658_28630	COG5002	protein histidine kinase activity
HC658_28640	COG0745	RESPONSE REGULATOR receiver
HC658_28650	COG0039	L-malate dehydrogenase activity
HC658_28660	COG0538	isocitrate dehydrogenase activity
HC658_28670	COG0372	Belongs to the citrate synthase family
HC658_28680	COG2707	UPF0756 membrane protein
HC658_28690	COG0628	permease
HC658_28700	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC658_28710	COG0469	pyruvate kinase activity
HC658_28720	COG0205	6-phosphofructokinase activity
HC658_28730	COG0825	malonyl-CoA metabolic process
HC658_28740	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC658_28750	COG0281	malic enzyme
HC658_28760	COG0587	DNA-directed DNA polymerase activity
HC658_28800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HC658_28820	COG4109	DRTGG domain
HC658_28830	COG0730	response to heat
HC658_28840	COG1473	amidohydrolase
HC658_28850	COG0196	riboflavin kinase activity
HC658_28860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_28870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HC658_28880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_28890	COG1126	abc transporter atp-binding protein
HC658_28900	COG0765	amino acid transport
HC658_28910	COG0765	amino acid transport
HC658_28920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_28930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_28940	COG0454	-acetyltransferase
HC658_28950	COG0583	DNA-binding transcription factor activity
HC658_28960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC658_28970	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_28990	COG0165	Argininosuccinate lyase
HC658_29000	COG0137	argininosuccinate synthase activity
HC658_29010	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC658_29020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HC658_29030	COG0827	DNA restriction-modification system
HC658_29040	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HC658_29050	COG3874	Sporulation protein YtfJ
HC658_29070	COG1714	RDD family
HC658_29080	COG0616	signal peptide processing
HC658_29090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC658_29100	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HC658_29110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC658_29130	COG0301	tRNA thio-modification
HC658_29140	COG1104	cysteine desulfurase activity
HC658_29150	COG1114	Component of the transport system for branched-chain amino acids
HC658_29160	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HC658_29170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC658_29180	COG1309	transcriptional regulator
HC658_29190	COG1956	GAF domain-containing protein
HC658_29200	COG2199	diguanylate cyclase activity
HC658_29200	COG2203	Gaf domain
HC658_29220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC658_29230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC658_29240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC658_29250	COG0454	-acetyltransferase
HC658_29260	COG0517	IMP dehydrogenase activity
HC658_29270	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC658_29280	COG1360	Flagellar Motor Protein
HC658_29290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC658_29300	COG1609	Transcriptional regulator
HC658_29310	COG1605	Chorismate mutase
HC658_29310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HC658_29320	COG3118	belongs to the thioredoxin family
HC658_29330	COG4980	gas vesicle protein
HC658_29340	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC658_29350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC658_29360	COG1674	ftsk spoiiie
HC658_29370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_29380	COG4848	Belongs to the UPF0354 family
HC658_29390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_29410	COG1363	Peptidase, m42
HC658_29420	COG5584	Small secreted protein
HC658_29430	COG0281	malic enzyme
HC658_29440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_29450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC658_29470	COG0510	thiamine kinase activity
HC658_29480	COG1523	belongs to the glycosyl hydrolase 13 family
HC658_29490	COG1597	lipid kinase activity
HC658_29510	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC658_29520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC658_29530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC658_29540	COG2252	PERMEase
HC658_29550	COG4473	ABC transporter
HC658_29560	COG1131	(ABC) transporter
HC658_29570	COG1349	DNA-binding transcription factor activity
HC658_29580	COG1187	pseudouridine synthase activity
HC658_29590	COG2244	polysaccharide biosynthetic process
HC658_29600	COG2081	HI0933 family
HC658_29610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC658_29630	COG5578	integral membrane protein
HC658_29640	COG0673	inositol 2-dehydrogenase activity
HC658_29650	COG1653	transport
HC658_29660	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC658_29670	COG4209	transmembrane transport
HC658_29680	COG2207	Transcriptional regulator
HC658_29690	COG1653	transport
HC658_29700	COG0395	ABC-type sugar transport system, permease component
HC658_29710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC658_29720	COG2124	cytochrome p450
HC658_29730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HC658_29750	COG0156	8-amino-7-oxononanoate synthase activity
HC658_29760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC658_29780	COG1073	alpha beta
HC658_29790	COG1609	Transcriptional regulator
HC658_29800	COG1653	transport
HC658_29810	COG1175	transmembrane transport
HC658_29820	COG0395	ABC-type sugar transport system, permease component
HC658_29830	COG1486	melibiose metabolic process
HC658_29840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC658_29850	COG0495	leucyl-tRNA aminoacylation
HC658_29870	COG2202	Pas domain
HC658_29870	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_29880	COG2814	Major facilitator Superfamily
HC658_29890	COG2433	Pfam Transposase IS66
HC658_29900	COG0577	efflux transmembrane transporter activity
HC658_29910	COG1136	(ABC) transporter
HC658_29920	COG2205	protein histidine kinase activity
HC658_29930	COG0745	RESPONSE REGULATOR receiver
HC658_29940	COG0577	efflux transmembrane transporter activity
HC658_29950	COG1136	(ABC) transporter
HC658_29980	COG1131	(ABC) transporter
HC658_29990	COG1725	Transcriptional regulator
HC658_30010	COG1242	4 iron, 4 sulfur cluster binding
HC658_30020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC658_30040	COG2267	carboxylic ester hydrolase activity
HC658_30050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC658_30060	COG1113	amino acid transport
HC658_30070	COG0367	asparagine synthase
HC658_30080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC658_30090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HC658_30110	COG1506	peptidase
HC658_30120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC658_30130	COG1116	anion transmembrane transporter activity
HC658_30140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC658_30150	COG0494	nUDIX hydrolase
HC658_30160	COG4824	toxin secretion phage lysis holin
HC658_30170	COG0783	Belongs to the Dps family
HC658_30190	COG1854	S-ribosylhomocysteine lyase activity
HC658_30200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC658_30210	COG0288	reversible hydration of carbon dioxide
HC658_30220	COG0254	rRNA binding
HC658_30230	COG1271	oxidase subunit
HC658_30240	COG1294	oxidase, subunit
HC658_30260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC658_30270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC658_30270	COG1321	iron dependent repressor
HC658_30280	COG1121	(ABC) transporter
HC658_30290	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC658_30300	COG4948	Mandelate Racemase Muconate Lactonizing
HC658_30310	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_30320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HC658_30330	COG0596	Alpha beta hydrolase
HC658_30340	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HC658_30350	COG1169	isochorismate synthase
HC658_30360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC658_30370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC658_30380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC658_30390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC658_30400	COG0438	transferase activity, transferring glycosyl groups
HC658_30420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_30430	COG0438	transferase activity, transferring glycosyl groups
HC658_30440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_30450	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HC658_30460	COG0058	SHG alpha-glucan phosphorylase activity
HC658_30470	COG0297	glycogen (starch) synthase activity
HC658_30480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC658_30490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC658_30500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HC658_30750	COG3859	Proton-coupled thiamine transporter YuaJ
HC658_30760	COG1247	-acetyltransferase
HC658_30770	COG2268	Band 7 protein
HC658_30780	COG1585	Membrane protein implicated in regulation of membrane protease activity
HC658_30790	COG2318	DinB family
HC658_30810	COG1454	alcohol dehydrogenase
HC658_30820	COG1012	belongs to the aldehyde dehydrogenase family
HC658_30830	COG1510	regulation of RNA biosynthetic process
HC658_30850	COG0569	domain protein
HC658_30860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC658_30870	COG4682	membrane
HC658_30880	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC658_30890	COG0477	Major facilitator Superfamily
HC658_30900	COG5553	Cysteine dioxygenase type I
HC658_30920	COG1968	undecaprenyl-diphosphatase activity
HC658_30930	COG0628	permease
HC658_30940	COG0673	inositol 2-dehydrogenase activity
HC658_30950	COG4806	L-rhamnose isomerase
HC658_30960	COG3254	rhamnose metabolic process
HC658_30970	COG1070	Carbohydrate kinase
HC658_30980	COG1349	DNA-binding transcription factor activity
HC658_30990	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_30990	COG3347	Dehydrogenase
HC658_31000	COG0840	transmembrane signaling receptor activity
HC658_31010	COG0840	transmembrane signaling receptor activity
HC658_31020	COG0840	transmembrane signaling receptor activity
HC658_31030	COG0840	transmembrane signaling receptor activity
HC658_31060	COG0432	Pfam Uncharacterised protein family UPF0047
HC658_31070	COG0366	Alpha amylase catalytic
HC658_31080	COG1253	flavin adenine dinucleotide binding
HC658_31090	COG2738	Putative neutral zinc metallopeptidase
HC658_31120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC658_31150	COG0166	Belongs to the GPI family
HC658_31160	COG1979	alcohol dehydrogenase
HC658_31170	COG1979	alcohol dehydrogenase
HC658_31180	COG2155	Conserved Protein
HC658_31190	COG1098	S1 RNA binding domain
HC658_31210	COG0436	Aminotransferase
HC658_31220	COG1522	sequence-specific DNA binding
HC658_31230	COG2267	carboxylic ester hydrolase activity
HC658_31250	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC658_31260	COG2205	protein histidine kinase activity
HC658_31280	COG5018	Exonuclease
HC658_31300	COG2814	Major facilitator Superfamily
HC658_31310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC658_31320	COG3011	Protein conserved in bacteria
HC658_31340	COG3290	protein histidine kinase activity
HC658_31350	COG4565	transcriptional regulatory protein
HC658_31400	COG3493	citrate carrier protein
HC658_31420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC658_31420	COG2111	Na H antiporter
HC658_31430	COG2111	Na H antiporter
HC658_31440	COG1006	Multisubunit Na H antiporter MnhC subunit
HC658_31450	COG0651	ATP synthesis coupled electron transport
HC658_31460	COG1863	multisubunit Na H antiporter MnhE subunit
HC658_31470	COG2212	antiporter activity
HC658_31480	COG1320	monovalent cation:proton antiporter activity
HC658_31490	COG2050	protein possibly involved in aromatic compounds catabolism
HC658_31500	COG2197	response regulator
HC658_31510	COG4585	Histidine kinase
HC658_31530	COG0142	geranyltranstransferase activity
HC658_31560	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HC658_31570	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HC658_31580	COG1335	isochorismatase
HC658_31590	COG5506	Protein of unknown function (DUF1694)
HC658_31620	COG0628	permease
HC658_31650	COG1418	mRNA catabolic process
HC658_31660	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_31680	COG1511	domain protein
HC658_31690	COG1674	ftsk spoiiie
HC658_31690	COG0433	COG0433 Predicted ATPase
HC658_31700	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC658_31710	COG5417	Belongs to the EsaB family
HC658_31720	COG4842	Belongs to the WXG100 family
HC658_31740	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC658_31740	COG2508	Transcriptional regulator
HC658_31750	COG0686	Belongs to the AlaDH PNT family
HC658_31760	COG5634	Uncharacterized conserved protein (DUF2278)
HC658_31770	COG3251	PFAM MbtH domain protein
HC658_31780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_31790	COG1535	isochorismatase
HC658_31790	COG3433	isochorismatase activity
HC658_31800	COG1021	2,3-dihydroxybenzoate-AMP ligase
HC658_31810	COG1169	isochorismate synthase
HC658_31820	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_31830	COG2819	hydrolase of the alpha beta superfamily
HC658_31840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC658_31850	COG1268	BioY protein
HC658_31860	COG2056	Na+-H+ antiporter family
HC658_31870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HC658_31880	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HC658_31890	COG3584	3D domain protein
HC658_31920	COG1252	NADH dehydrogenase
HC658_31930	COG0492	ferredoxin-NADP+ reductase activity
HC658_31950	COG0516	GMP reductase activity
HC658_31960	COG2808	Putative FMN-binding domain
HC658_31970	COG0456	acetyltransferase
HC658_31980	COG0316	Belongs to the HesB IscA family
HC658_31990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HC658_32000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC658_32010	COG4844	belongs to the
HC658_32020	COG1252	NADH dehydrogenase
HC658_32030	COG4837	Protein of unknown function (DUF1462)
HC658_32040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HC658_32050	COG0823	Involved in the tonB-independent uptake of proteins
HC658_32050	COG1506	peptidase
HC658_32050	COG4946	Tricorn protease homolog
HC658_32060	COG0083	homoserine kinase activity
HC658_32070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC658_32080	COG0460	homoserine dehydrogenase
HC658_32090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_32100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC658_32110	COG0647	UMP catabolic process
HC658_32120	COG2445	Protein of unknown function DUF86
HC658_32130	COG4470	Protein conserved in bacteria
HC658_32150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HC658_32160	COG0739	heme binding
HC658_32180	COG3377	Domain of unknown function (DUF1805)
HC658_32190	COG0737	Belongs to the 5'-nucleotidase family
HC658_32200	COG0730	response to heat
HC658_32210	COG1801	Protein of unknown function DUF72
HC658_32230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC658_32240	COG2508	Transcriptional regulator
HC658_32250	COG2233	PERMEase
HC658_32260	COG2233	PERMEase
HC658_32270	COG3648	Uricase
HC658_32270	COG3195	allantoin biosynthetic process
HC658_32280	COG2351	hydroxyisourate hydrolase activity
HC658_32300	COG2080	2 iron, 2 sulfur cluster binding
HC658_32310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC658_32320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HC658_32330	COG2068	MobA-Related Protein
HC658_32340	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HC658_32350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC658_32360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC658_32370	COG2356	endonuclease I
HC658_32380	COG3842	ATPase activity
HC658_32390	COG2188	Transcriptional regulator
HC658_32400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_32410	COG0395	ABC-type sugar transport system, permease component
HC658_32420	COG1175	transmembrane transport
HC658_32430	COG1653	transport
HC658_32440	COG2222	sugar isomerase
HC658_32450	COG0322	excinuclease ABC activity
HC658_32460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC658_32480	COG0346	lactoylglutathione lyase activity
HC658_32490	COG0719	Fe-S assembly protein
HC658_32500	COG0822	iron-sulfur transferase activity
HC658_32510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC658_32520	COG0719	Fe-S assembly protein
HC658_32530	COG0396	ATPase activity
HC658_32550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC658_32560	COG1464	Belongs to the NlpA lipoprotein family
HC658_32570	COG2011	ABC-type metal ion transport system permease component
HC658_32580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC658_32600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_32610	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC658_32630	COG0509	glycine decarboxylation via glycine cleavage system
HC658_32640	COG1393	Belongs to the ArsC family
HC658_32650	COG1960	acyl-CoA dehydrogenase activity
HC658_32660	COG0183	Belongs to the thiolase family
HC658_32670	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC658_32670	COG1024	Enoyl-CoA hydratase
HC658_32690	COG0506	proline dehydrogenase activity
HC658_32710	COG5577	PFAM Coat F domain
HC658_32720	COG1846	Transcriptional regulator
HC658_32730	COG0477	Major facilitator Superfamily
HC658_32740	COG1942	4-Oxalocrotonate Tautomerase
HC658_32750	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_32760	COG0583	DNA-binding transcription factor activity
HC658_32780	COG1120	ATPase activity
HC658_32810	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_32820	COG0783	Belongs to the Dps family
HC658_32830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC658_32840	COG0745	RESPONSE REGULATOR receiver
HC658_32850	COG2770	Histidine kinase
HC658_32850	COG2205	protein histidine kinase activity
HC658_32870	COG1309	transcriptional regulator
HC658_32880	COG0114	fumarate hydratase activity
HC658_32900	COG0697	spore germination
HC658_32910	COG0814	amino acid
HC658_32930	COG2197	response regulator
HC658_32940	COG4585	Histidine kinase
HC658_32950	COG4758	membrane
HC658_32960	COG3595	metallopeptidase activity
HC658_32970	COG1842	Phage shock protein A
HC658_32980	COG4758	membrane
HC658_32990	COG2814	Major facilitator Superfamily
HC658_33000	COG2096	Adenosyltransferase
HC658_33010	COG1120	ATPase activity
HC658_33020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_33030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_33040	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_33050	COG3386	PFAM SMP-30 Gluconolaconase
HC658_33060	COG2205	protein histidine kinase activity
HC658_33070	COG0745	RESPONSE REGULATOR receiver
HC658_33090	COG1191	sigma factor activity
HC658_33110	COG2140	Oxalate decarboxylase
HC658_33130	COG0577	efflux transmembrane transporter activity
HC658_33140	COG1136	(ABC) transporter
HC658_33150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC658_33160	COG1120	ATPase activity
HC658_33170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_33180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_33190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_33210	COG0531	amino acid
HC658_33230	COG1988	membrane-bound metal-dependent
HC658_33240	COG1368	sulfuric ester hydrolase activity
HC658_33250	COG1910	domain protein
HC658_33260	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC658_33270	COG4149	molybdate abc transporter
HC658_33280	COG0656	L-ascorbic acid biosynthetic process
HC658_33300	COG0025	NhaP-type Na H and K H
HC658_33310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC658_33320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC658_33330	COG3973	AAA domain
HC658_33350	COG2860	membrane
HC658_33360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HC658_33370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC658_33380	COG2217	Heavy metal translocating P-type atpase
HC658_33390	COG2217	Heavy metal translocating P-type atpase
HC658_33400	COG2608	mercury ion transmembrane transporter activity
HC658_33410	COG1937	Protein conserved in bacteria
HC658_33420	COG0673	inositol 2-dehydrogenase activity
HC658_33430	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC658_33440	COG1289	transmembrane transporter activity
HC658_33460	COG2076	Multidrug Resistance protein
HC658_33470	COG1309	transcriptional regulator
HC658_33480	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_33490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HC658_33500	COG0557	exoribonuclease II activity
HC658_33510	COG1647	Serine aminopeptidase, S33
HC658_33520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC658_33530	COG0596	Alpha beta hydrolase
HC658_33540	COG1396	sequence-specific DNA binding
HC658_33550	COG1396	sequence-specific DNA binding
HC658_33560	COG1733	regulation of RNA biosynthetic process
HC658_33570	COG0840	transmembrane signaling receptor activity
HC658_33580	COG1174	glycine betaine transport
HC658_33590	COG1732	Glycine betaine
HC658_33600	COG1174	glycine betaine transport
HC658_33610	COG1125	glycine betaine transport
HC658_33610	COG0517	IMP dehydrogenase activity
HC658_33620	COG1510	regulation of RNA biosynthetic process
HC658_33650	COG5658	integral membrane protein
HC658_33660	COG0640	Transcriptional regulator
HC658_33670	COG1174	glycine betaine transport
HC658_33680	COG1732	Glycine betaine
HC658_33690	COG1174	glycine betaine transport
HC658_33700	COG0517	IMP dehydrogenase activity
HC658_33700	COG1125	glycine betaine transport
HC658_33710	COG1510	regulation of RNA biosynthetic process
HC658_33720	COG2095	MarC family integral membrane protein
HC658_33740	COG3064	Membrane
HC658_33750	COG4640	response to antibiotic
HC658_33760	COG0456	acetyltransferase
HC658_33770	COG0148	phosphopyruvate hydratase activity
HC658_33780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HC658_33790	COG0149	triose-phosphate isomerase activity
HC658_33800	COG0126	phosphoglycerate kinase activity
HC658_33810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC658_33820	COG2390	Transcriptional regulator
HC658_33830	COG2814	Major facilitator Superfamily
HC658_33840	COG1609	Transcriptional regulator
HC658_33850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_33860	COG0583	DNA-binding transcription factor activity
HC658_33870	COG0697	spore germination
HC658_33880	COG1113	amino acid transport
HC658_33890	COG3858	chitin binding
HC658_33900	COG1556	Lactate utilization protein
HC658_33910	COG1139	Iron-sulfur cluster binding protein
HC658_33920	COG0247	lactate metabolic process
HC658_33930	COG2197	response regulator
HC658_33940	COG4585	Histidine kinase
HC658_33950	COG0842	Transport permease protein
HC658_33960	COG1131	(ABC) transporter
HC658_33970	COG0596	Alpha beta hydrolase
HC658_33980	COG2208	phosphoserine phosphatase activity
HC658_33990	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HC658_34000	COG1874	Beta-galactosidase
HC658_34010	COG3833	ABC-type maltose transport systems, permease component
HC658_34020	COG1175	transmembrane transport
HC658_34030	COG2182	Extracellular solute-binding protein
HC658_34040	COG1609	Transcriptional regulator
HC658_34050	COG2186	Transcriptional regulator
HC658_34060	COG1620	l-lactate permease
HC658_34070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC658_34090	COG5039	Polysaccharide pyruvyl transferase
HC658_34100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC658_34110	COG0110	maltose O-acetyltransferase activity
HC658_34120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC658_34130	COG2244	polysaccharide biosynthetic process
HC658_34140	COG1216	Glycosyl transferase, family 2
HC658_34150	COG5039	Polysaccharide pyruvyl transferase
HC658_34160	COG1216	Glycosyl transferase, family 2
HC658_34180	COG0438	transferase activity, transferring glycosyl groups
HC658_34190	COG1215	transferase activity, transferring glycosyl groups
HC658_34200	COG0438	transferase activity, transferring glycosyl groups
HC658_34210	COG1086	Polysaccharide biosynthesis protein
HC658_34220	COG0489	protein tyrosine kinase activity
HC658_34230	COG3944	biosynthesis protein
HC658_34240	COG1396	sequence-specific DNA binding
HC658_34250	COG2272	Belongs to the type-B carboxylesterase lipase family
HC658_34270	COG3479	Phenolic acid decarboxylase
HC658_34290	COG1794	racemase activity, acting on amino acids and derivatives
HC658_34300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC658_34310	COG1621	beta-fructofuranosidase activity
HC658_34320	COG1621	beta-fructofuranosidase activity
HC658_34330	COG0531	amino acid
HC658_34340	COG1309	transcriptional regulator
HC658_34350	COG2076	Multidrug Resistance protein
HC658_34360	COG2076	Multidrug Resistance protein
HC658_34380	COG0277	FAD linked oxidase domain protein
HC658_34390	COG3621	Patatin-like phospholipase
HC658_34410	COG0740	serine-type endopeptidase activity
HC658_34420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC658_34430	COG0366	Alpha amylase catalytic
HC658_34440	COG1554	hydrolase, family 65, central catalytic
HC658_34450	COG5521	maltodextrose utilization protein MalA
HC658_34460	COG3833	ABC-type maltose transport systems, permease component
HC658_34470	COG1175	transmembrane transport
HC658_34480	COG2182	Extracellular solute-binding protein
HC658_34490	COG0366	Alpha amylase catalytic
HC658_34500	COG1609	Transcriptional regulator
HC658_34510	COG1611	Belongs to the LOG family
HC658_34520	COG1694	Mazg nucleotide pyrophosphohydrolase
HC658_34530	COG0659	secondary active sulfate transmembrane transporter activity
HC658_34540	COG0288	reversible hydration of carbon dioxide
HC658_34550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC658_34560	COG0577	efflux transmembrane transporter activity
HC658_34570	COG1136	(ABC) transporter
HC658_34580	COG5002	protein histidine kinase activity
HC658_34590	COG0745	RESPONSE REGULATOR receiver
HC658_34610	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HC658_34620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_34630	COG1481	regulation of sporulation
HC658_34640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC658_34650	COG1660	Displays ATPase and GTPase activities
HC658_34660	COG1051	belongs to the nudix hydrolase family
HC658_34670	COG0492	ferredoxin-NADP+ reductase activity
HC658_34680	COG0791	NLP P60 protein
HC658_34680	COG3883	PFAM NLP P60 protein
HC658_34690	COG0457	Tetratricopeptide repeat
HC658_34700	COG1132	(ABC) transporter
HC658_34740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HC658_34740	COG0140	phosphoribosyl-ATP diphosphatase activity
HC658_34750	COG0107	imidazoleglycerol-phosphate synthase activity
HC658_34760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HC658_34770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC658_34780	COG0131	Imidazoleglycerol-phosphate dehydratase
HC658_34790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HC658_34800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HC658_34810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HC658_34820	COG4990	cell redox homeostasis
HC658_34830	COG5297	Belongs to the glycosyl hydrolase family 6
HC658_34840	COG0110	maltose O-acetyltransferase activity
HC658_34850	COG0546	phosphoglycolate phosphatase activity
HC658_34860	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HC658_34870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC658_34880	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HC658_34890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC658_34900	COG0363	glucosamine-6-phosphate deaminase activity
HC658_34910	COG2188	Transcriptional regulator
HC658_34920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC658_34930	COG1846	Transcriptional regulator
HC658_34940	COG2124	cytochrome p450
HC658_34960	COG1846	Transcriptional regulator
HC658_34970	COG2814	Major facilitator Superfamily
HC658_34980	COG1950	PFAM Membrane protein of
HC658_34990	COG1983	PspC domain protein
HC658_35000	COG3595	metallopeptidase activity
HC658_35030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC658_35040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC658_35050	COG0556	nucleotide-excision repair
HC658_35060	COG4897	Protein conserved in bacteria
HC658_35070	COG0574	Belongs to the PEP-utilizing enzyme family
HC658_35070	COG3848	Pyruvate phosphate dikinase
HC658_35080	COG1309	transcriptional regulator
HC658_35090	COG2814	Major facilitator Superfamily
HC658_35100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC658_35120	COG0793	Belongs to the peptidase S41A family
HC658_35120	COG3409	Peptidoglycan-binding domain 1 protein
HC658_35130	COG2177	Part of the ABC transporter FtsEX involved in
HC658_35140	COG2884	Cell division ATP-binding protein ftsE
HC658_35150	COG2010	Cytochrome c
HC658_35160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_35170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HC658_35180	COG0653	protein targeting
HC658_35190	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC658_35220	COG1516	flagellar protein fliS
HC658_35230	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HC658_35240	COG1334	flagellar protein FlaG
HC658_35250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC658_35260	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC658_35270	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HC658_35290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC658_35300	COG4786	Flagellar basal body rod
HC658_35300	COG1256	bacterial-type flagellum assembly
HC658_35310	COG3418	PFAM FlgN family protein
HC658_35320	COG2747	anti-sigma28 factor FlgM
HC658_35340	COG1040	competence protein
HC658_35360	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HC658_35370	COG1307	EDD domain protein, DegV family
HC658_35380	COG2197	response regulator
HC658_35390	COG4585	Histidine kinase
HC658_35400	COG1739	Uncharacterized protein family UPF0029
HC658_35410	COG1316	TRANSCRIPTIONal
HC658_35420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC658_35430	COG0438	transferase activity, transferring glycosyl groups
HC658_35440	COG1215	transferase activity, transferring glycosyl groups
HC658_35450	COG3206	protein involved in exopolysaccharide biosynthesis
HC658_35460	COG3307	-O-antigen
HC658_35470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC658_35480	COG0438	transferase activity, transferring glycosyl groups
HC658_35480	COG0297	glycogen (starch) synthase activity
HC658_35490	COG2244	polysaccharide biosynthetic process
HC658_35510	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_35510	COG2247	cell wall binding repeat
HC658_35520	COG2247	cell wall binding repeat
HC658_35520	COG2385	sporulation resulting in formation of a cellular spore
HC658_35540	COG1316	TRANSCRIPTIONal
HC658_35550	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HC658_35560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC658_35570	COG1682	transport, permease protein
HC658_35580	COG1215	transferase activity, transferring glycosyl groups
HC658_35580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC658_35590	COG0463	Glycosyl transferase, family 2
HC658_35610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC658_35620	COG1134	teichoic acid transport
HC658_35630	COG1682	transport, permease protein
HC658_35640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC658_35650	COG0438	transferase activity, transferring glycosyl groups
HC658_35660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HC658_35670	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HC658_35680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC658_35700	COG4193	domain, Protein
HC658_35710	COG1482	cell wall glycoprotein biosynthetic process
HC658_35720	COG0697	spore germination
HC658_35730	COG0814	amino acid
HC658_35750	COG2814	Major facilitator Superfamily
HC658_35760	COG1316	TRANSCRIPTIONal
HC658_35770	COG0561	phosphatase activity
HC658_35780	COG0791	NLP P60 protein
HC658_35800	COG2843	Capsule synthesis protein
HC658_35820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC658_35830	COG1609	Transcriptional regulator
HC658_35840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_35850	COG1869	D-ribose catabolic process
HC658_35860	COG1129	ABC transporter
HC658_35870	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC658_35880	COG1879	ABC-type sugar transport system periplasmic component
HC658_35890	COG3103	Sh3 type 3 domain protein
HC658_35910	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC658_35920	COG3527	Alpha-acetolactate decarboxylase
HC658_35930	COG0028	Belongs to the TPP enzyme family
HC658_35940	COG0583	DNA-binding transcription factor activity
HC658_35950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC658_35980	COG5337	Spore coat protein CotH
HC658_36000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC658_36020	COG0405	Gamma-glutamyltransferase
HC658_36030	COG1522	sequence-specific DNA binding
HC658_36040	COG2059	Chromate
HC658_36050	COG2059	Chromate
HC658_36070	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC658_36080	COG0583	DNA-binding transcription factor activity
HC658_36090	COG1515	deoxyribonuclease V activity
HC658_36100	COG5444	nuclease activity
HC658_36140	COG3878	Protein conserved in bacteria
HC658_36150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC658_36160	COG4464	protein tyrosine phosphatase activity
HC658_36170	COG0489	protein tyrosine kinase activity
HC658_36180	COG3944	biosynthesis protein
HC658_36200	COG4715	Zinc finger, swim domain protein
HC658_36210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC658_36220	COG0561	phosphatase activity
HC658_36230	COG1349	DNA-binding transcription factor activity
HC658_36240	COG0629	single-stranded DNA binding
HC658_36270	COG3764	Sortase (surface protein transpeptidase)
HC658_36290	COG0745	RESPONSE REGULATOR receiver
HC658_36290	COG2972	Histidine kinase
HC658_36300	COG1970	mechanosensitive ion channel activity
HC658_36310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC658_36320	COG0457	Tetratricopeptide repeat
HC658_36330	COG4786	Flagellar basal body rod
HC658_36340	COG4786	Flagellar basal body rod
HC658_36350	COG1077	Cell shape determining protein MreB Mrl
HC658_36360	COG1609	Transcriptional regulator
HC658_36370	COG1846	Transcriptional regulator
HC658_36380	COG2814	Major facilitator Superfamily
HC658_36390	COG3420	alginic acid biosynthetic process
HC658_36400	COG1953	Uracil, thiamine, allantoin
HC658_36410	COG0477	Major facilitator Superfamily
HC658_36420	COG1335	isochorismatase
HC658_36440	COG0004	ammonium transporteR
HC658_36450	COG0347	Belongs to the P(II) protein family
HC658_36460	COG0671	phosphoesterase, PA-phosphatase related
HC658_36480	COG0739	heme binding
HC658_36490	COG1247	-acetyltransferase
HC658_36520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC658_36530	COG0789	Transcriptional regulator
HC658_36550	COG2910	NAD(P)H-binding
HC658_36560	COG1959	2 iron, 2 sulfur cluster binding
HC658_36570	COG0804	urea catabolic process
HC658_36580	COG0832	Belongs to the urease beta subunit family
HC658_36590	COG0831	urea catabolic process
HC658_36620	COG3237	CsbD-like
HC658_36630	COG1994	Peptidase M50
HC658_36640	COG0457	Tetratricopeptide repeat
HC658_36650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC658_36660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HC658_36680	COG2304	oxidoreductase activity
HC658_36690	COG2304	oxidoreductase activity
HC658_36700	COG2385	sporulation resulting in formation of a cellular spore
HC658_36710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC658_36730	COG4836	Membrane
HC658_36750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HC658_36760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC658_36770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HC658_36780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HC658_36790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC658_36800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC658_36820	COG0356	it plays a direct role in the translocation of protons across the membrane
HC658_36840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HC658_36850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC658_36860	COG4475	Protein of unknown function (DUF436)
HC658_36870	COG0698	ribose 5-phosphate isomerase
HC658_36880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC658_36890	COG1971	Probably functions as a manganese efflux pump
HC658_36900	COG0009	L-threonylcarbamoyladenylate synthase
HC658_36910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC658_36950	COG2890	protein-(glutamine-N5) methyltransferase activity
HC658_36960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC658_36970	COG0346	lactoylglutathione lyase activity
HC658_36980	COG0789	Transcriptional regulator
HC658_36990	COG0679	Auxin Efflux Carrier
HC658_37000	COG0281	malic enzyme
HC658_37010	COG1435	thymidine kinase activity
HC658_37030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC658_37050	COG1494	fructose-1,6-bisphosphatase
HC658_37060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC658_37070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC658_37080	COG0191	fructose-bisphosphate aldolase activity
HC658_37090	COG2204	response regulator
HC658_37100	COG4821	SIS domain
HC658_37110	COG0504	CTP synthase activity
HC658_37120	COG3343	RNA polymerase activity
HC658_37130	COG1960	acyl-CoA dehydrogenase activity
HC658_37140	COG0247	lactate metabolic process
HC658_37140	COG2181	nitrate reductase activity
HC658_37150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC658_37160	COG4294	response to UV
HC658_37180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC658_37190	COG1132	(ABC) transporter
HC658_37200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC658_37210	COG2181	nitrate reductase activity
HC658_37220	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC658_37230	COG1140	nitrate reductase beta subunit
HC658_37240	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC658_37250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC658_37270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC658_37280	COG2223	nitrite transmembrane transporter activity
HC658_37290	COG0018	arginyl-trna synthetase
HC658_37300	COG4506	Protein conserved in bacteria
HC658_37320	COG0535	radical SAM domain protein
HC658_37340	COG1131	(ABC) transporter
HC658_37350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC658_37360	COG0612	Peptidase, M16
HC658_37370	COG0612	Peptidase, M16
HC658_37390	COG3391	amine dehydrogenase activity
HC658_37400	COG3391	amine dehydrogenase activity
HC658_37410	COG0457	Tetratricopeptide repeat
HC658_37430	COG0010	Belongs to the arginase family
HC658_37440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC658_37450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC658_37470	COG1994	Peptidase M50
HC658_37480	COG1942	4-Oxalocrotonate Tautomerase
HC658_37490	COG1846	Transcriptional regulator
HC658_37500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC658_37520	COG0477	Major facilitator Superfamily
HC658_37530	COG1959	2 iron, 2 sulfur cluster binding
HC658_37540	COG3465	dGTPase activity
HC658_37550	COG1078	dGTPase activity
HC658_37560	COG4844	belongs to the
HC658_37580	COG0697	spore germination
HC658_37600	COG0095	Lipoate-protein ligase
HC658_37610	COG0583	DNA-binding transcription factor activity
HC658_37620	COG0280	phosphate acetyltransferase
HC658_37640	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_37650	COG0436	Aminotransferase
HC658_37660	COG2814	Major facilitator Superfamily
HC658_37670	COG0151	Belongs to the GarS family
HC658_37680	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_37690	COG1917	Cupin 2, conserved barrel domain protein
HC658_37700	COG0077	Prephenate dehydratase
HC658_37710	COG2814	Major facilitator Superfamily
HC658_37720	COG0833	amino acid
HC658_37730	COG4187	Peptidase family M20/M25/M40
HC658_37740	COG1012	belongs to the aldehyde dehydrogenase family
HC658_37750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC658_37770	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC658_37780	COG1091	dTDP-4-dehydrorhamnose reductase activity
HC658_37790	COG1088	dTDP-glucose 4,6-dehydratase activity
HC658_37800	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC658_37810	COG3980	spore coat polysaccharide biosynthesis protein
HC658_37820	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HC658_37830	COG2089	acid synthase
HC658_37840	COG0456	acetyltransferase
HC658_37850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC658_37860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC658_37870	COG0463	Glycosyl transferase, family 2
HC658_37890	COG2363	Small membrane protein
HC658_37900	COG2233	PERMEase
HC658_37920	COG1012	belongs to the aldehyde dehydrogenase family
HC658_37930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC658_37940	COG1216	Glycosyl transferase, family 2
HC658_37950	COG0351	phosphomethylpyrimidine kinase
HC658_37970	COG1621	beta-fructofuranosidase activity
HC658_37980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_37980	COG1263	PTS System
HC658_37990	COG2116	formate transmembrane transporter activity
HC658_38000	COG3711	transcriptional antiterminator
HC658_38020	COG1404	Belongs to the peptidase S8 family
HC658_38030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_38040	COG0778	Nitroreductase
HC658_38050	COG0772	Belongs to the SEDS family
HC658_38070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC658_38080	COG1845	cytochrome c oxidase, subunit III
HC658_38090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC658_38100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC658_38110	COG2261	transglycosylase associated protein
HC658_38120	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HC658_38130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC658_38140	COG2246	polysaccharide biosynthetic process
HC658_38150	COG1309	transcriptional regulator
HC658_38170	COG3162	membrane
HC658_38180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_38190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HC658_38200	COG2837	iron assimilation
HC658_38210	COG2822	iron ion transport
HC658_38220	COG0672	)-iron permease
HC658_38230	COG0352	thiamine-phosphate diphosphorylase activity
HC658_38240	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HC658_38250	COG0583	DNA-binding transcription factor activity
HC658_38260	COG1380	Effector of murein hydrolase LrgA
HC658_38270	COG1346	cytolysis
HC658_38280	COG2814	Major facilitator Superfamily
HC658_38290	COG4895	conserved protein (DUF2196)
HC658_38300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HC658_38310	COG0346	lactoylglutathione lyase activity
HC658_38340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_38350	COG1404	Belongs to the peptidase S8 family
HC658_38360	COG1263	PTS System
HC658_38360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_38370	COG3711	transcriptional antiterminator
HC658_38380	COG1442	glycosyl transferase family 8
HC658_38390	COG5522	Integral membrane protein (intg_mem_TP0381)
HC658_38400	COG1846	Transcriptional regulator
HC658_38410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC658_38420	COG2234	aminopeptidase activity
HC658_38450	COG2814	Major facilitator Superfamily
HC658_38460	COG2357	RelA SpoT domain protein
HC658_38470	COG1575	Belongs to the MenA family. Type 1 subfamily
HC658_38490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_38500	COG1696	Membrane protein involved in D-alanine export
HC658_38510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_38520	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HC658_38530	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HC658_38540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC658_38550	COG1486	melibiose metabolic process
HC658_38560	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC658_38570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_38580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_38590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_38590	COG3711	transcriptional antiterminator
HC658_38610	COG2094	Belongs to the DNA glycosylase MPG family
HC658_38620	COG0753	catalase activity
HC658_38630	COG2814	Major facilitator Superfamily
HC658_38640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC658_38650	COG1131	(ABC) transporter
HC658_38690	COG1595	DNA-templated transcription, initiation
HC658_38700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC658_38710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC658_38720	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC658_38730	COG4988	ABC transporter
HC658_38740	COG1294	oxidase, subunit
HC658_38750	COG1271	oxidase subunit
HC658_38760	COG3493	citrate carrier protein
HC658_38770	COG0501	Belongs to the peptidase M48B family
HC658_38780	COG0726	polysaccharide deacetylase
HC658_38790	COG3842	ATPase activity
HC658_38800	COG2508	Transcriptional regulator
HC658_38810	COG1012	belongs to the aldehyde dehydrogenase family
HC658_38820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_38840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HC658_38860	COG4585	Histidine kinase
HC658_38870	COG2197	response regulator
HC658_38880	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC658_38900	COG4894	glucomannan catabolic process
HC658_38910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC658_38920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC658_38930	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_38940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC658_38950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC658_38960	COG2610	gluconate transmembrane transporter activity
HC658_38970	COG0500	methyltransferase
HC658_38980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC658_39010	COG0693	protein deglycase activity
HC658_39010	COG0753	catalase activity
HC658_39020	COG2851	Citrate transporter
HC658_39030	COG2273	Hydrolase Family 16
HC658_39040	COG3711	transcriptional antiterminator
HC658_39060	COG2270	Major facilitator Superfamily
HC658_39070	COG0513	Belongs to the DEAD box helicase family
HC658_39080	COG3401	FG-GAP repeat protein
HC658_39080	COG2755	lipolytic protein G-D-S-L family
HC658_39190	COG3209	COG3209 Rhs family protein
HC658_39200	COG0697	spore germination
HC658_39210	COG0589	response to stress
HC658_39220	COG2723	6-phospho-beta-galactosidase activity
HC658_39230	COG1263	PTS System
HC658_39230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_39230	COG2190	(PTS) system
HC658_39260	COG5444	nuclease activity
HC658_39290	COG5444	nuclease activity
HC658_39320	COG3507	Belongs to the glycosyl hydrolase 43 family
HC658_39350	COG2986	histidine ammonia-lyase
HC658_39360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HC658_39370	COG1228	amidohydrolase
HC658_39380	COG0010	Belongs to the arginase family
HC658_39390	COG0833	amino acid
HC658_39400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HC658_39410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC658_39420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HC658_39430	COG2390	Transcriptional regulator
HC658_39450	COG3192	ethanolamine utilization protein
HC658_39460	COG2079	MmgE PrpD family protein
HC658_39470	COG1473	amidohydrolase
HC658_39480	COG1126	abc transporter atp-binding protein
HC658_39490	COG0765	amino acid transport
HC658_39500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_39510	COG0456	acetyltransferase
HC658_39520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_39530	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC658_39540	COG0561	phosphatase activity
HC658_39600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_39610	COG5294	Protein conserved in bacteria
HC658_39620	COG0577	efflux transmembrane transporter activity
HC658_39630	COG1136	(ABC) transporter
HC658_39640	COG2205	protein histidine kinase activity
HC658_39650	COG0745	RESPONSE REGULATOR receiver
HC658_39660	COG0191	fructose-bisphosphate aldolase activity
HC658_39670	COG1082	Xylose isomerase domain protein TIM barrel
HC658_39680	COG1082	Xylose isomerase domain protein TIM barrel
HC658_39690	COG0673	inositol 2-dehydrogenase activity
HC658_39700	COG2814	Major facilitator Superfamily
HC658_39710	COG1082	Xylose isomerase domain protein TIM barrel
HC658_39720	COG3962	Belongs to the TPP enzyme family
HC658_39730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_39740	COG3718	enzyme involved in inositol metabolism
HC658_39750	COG1012	belongs to the aldehyde dehydrogenase family
HC658_39760	COG1349	DNA-binding transcription factor activity
HC658_39770	COG0667	Aldo Keto reductase
HC658_39810	COG2814	Major facilitator Superfamily
HC658_39820	COG0326	Molecular chaperone. Has ATPase activity
HC658_39840	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_39850	COG1309	transcriptional regulator
HC658_39860	COG1012	belongs to the aldehyde dehydrogenase family
HC658_39880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC658_39900	COG1714	RDD family
HC658_39910	COG2311	Membrane
HC658_39920	COG1917	Cupin 2, conserved barrel domain protein
HC658_39930	COG1309	transcriptional regulator
HC658_39940	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_39950	COG1846	Transcriptional regulator
HC658_39960	COG1380	Effector of murein hydrolase LrgA
HC658_39970	COG1346	cytolysis
HC658_39980	COG5039	Polysaccharide pyruvyl transferase
HC658_39990	COG1929	Belongs to the glycerate kinase type-1 family
HC658_40000	COG1802	Transcriptional regulator
HC658_40010	COG1070	Carbohydrate kinase
HC658_40020	COG2610	gluconate transmembrane transporter activity
HC658_40030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC658_40040	COG0450	alkyl hydroperoxide reductase
HC658_40050	COG3634	alkyl hydroperoxide reductase activity
HC658_40060	COG2723	6-phospho-beta-galactosidase activity
HC658_40070	COG1263	PTS System
HC658_40070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_40070	COG2190	(PTS) system
HC658_40080	COG2188	Transcriptional regulator
HC658_40100	COG1131	(ABC) transporter
HC658_40110	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HC658_40130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HC658_40160	COG1063	alcohol dehydrogenase
HC658_40200	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HC658_40210	COG0456	acetyltransferase
HC658_40220	COG0457	Tetratricopeptide repeat
HC658_40240	COG0010	Belongs to the arginase family
HC658_40250	COG0833	amino acid
HC658_40260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC658_40270	COG3829	transcription factor binding
HC658_40280	COG5002	protein histidine kinase activity
HC658_40320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC658_40330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC658_40340	COG4853	Protein conserved in bacteria
HC658_40350	COG4863	YycH protein
HC658_40360	COG5002	protein histidine kinase activity
HC658_40370	COG0745	RESPONSE REGULATOR receiver
HC658_40430	COG0346	lactoylglutathione lyase activity
HC658_40440	COG0305	Participates in initiation and elongation during chromosome replication
HC658_40470	COG3093	addiction module antidote protein HigA
HC658_40480	COG2807	transmembrane transport
HC658_40490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC658_40500	COG0359	binds to the 23S rRNA
HC658_40510	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HC658_40520	COG4241	membrane
HC658_40540	COG5577	PFAM Coat F domain
HC658_40550	COG1733	regulation of RNA biosynthetic process
HC658_40560	COG1227	inorganic diphosphatase activity
HC658_40590	COG2271	Major facilitator Superfamily
HC658_40610	COG4319	ketosteroid isomerase
HC658_40620	COG2271	Major facilitator Superfamily
HC658_40680	COG1131	(ABC) transporter
HC658_40700	COG4319	ketosteroid isomerase
HC658_40710	COG1357	PFAM Pentapeptide repeats (8 copies)
HC658_40720	COG2814	Major facilitator Superfamily
HC658_40730	COG0583	DNA-binding transcription factor activity
HC658_40740	COG2153	protein acetylation
HC658_40760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_40770	COG1846	Transcriptional regulator
HC658_40780	COG2153	protein acetylation
HC658_40790	COG2364	Membrane
HC658_40800	COG0456	acetyltransferase
HC658_40810	COG2315	Protein conserved in bacteria
HC658_40820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC658_40830	COG2814	Major facilitator Superfamily
HC658_40840	COG1331	Highly conserved protein containing a thioredoxin domain
HC658_40870	COG0789	Transcriptional regulator
HC658_40880	COG0697	spore germination
HC658_40890	COG1331	Highly conserved protein containing a thioredoxin domain
HC658_40900	COG1280	lysine exporter protein (LysE YggA)
HC658_40910	COG1331	Highly conserved protein containing a thioredoxin domain
HC658_40920	COG1331	Highly conserved protein containing a thioredoxin domain
HC658_40930	COG1266	CAAX protease self-immunity
HC658_40940	COG2814	Major facilitator Superfamily
HC658_40940	COG0477	Major facilitator Superfamily
HC658_40950	COG0110	maltose O-acetyltransferase activity
HC658_40960	COG0346	lactoylglutathione lyase activity
HC658_40970	COG1609	Transcriptional regulator
HC658_40980	COG0708	Exodeoxyribonuclease III
HC658_40990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC658_41000	COG0629	single-stranded DNA binding
HC658_41010	COG0360	Binds together with S18 to 16S ribosomal RNA
HC658_41020	COG0012	GTP binding
HC658_41030	COG0243	molybdopterin cofactor binding
HC658_41040	COG4481	Protein conserved in bacteria
HC658_41050	COG3949	Membrane
HC658_41070	COG1475	DNA binding
HC658_41080	COG1192	Involved in chromosome partitioning
HC658_41100	COG1475	DNA binding
HC658_41110	COG0357	Ribosomal RNA small subunit methyltransferase G
HC658_41120	COG0445	tRNA wobble uridine modification
HC658_41130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HC658_41140	COG1847	R3H domain protein
HC658_41150	COG0706	membrane insertase activity
HC658_41160	COG0594	ribonuclease P activity