locus-tag	class	description
HC659_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC659_00020	COG0592	DNA-directed DNA polymerase activity
HC659_00030	COG2501	S4 domain
HC659_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC659_00060	COG0187	DNA topoisomerase II activity
HC659_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC659_00140	COG0516	GMP reductase activity
HC659_00140	COG0517	IMP dehydrogenase activity
HC659_00150	COG1686	Belongs to the peptidase S11 family
HC659_00160	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HC659_00170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HC659_00180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC659_00200	COG1428	Deoxynucleoside kinase
HC659_00210	COG1428	Deoxynucleoside kinase
HC659_00220	COG1388	LysM domain
HC659_00220	COG3858	chitin binding
HC659_00230	COG1335	isochorismatase
HC659_00240	COG0590	tRNA wobble adenosine to inosine editing
HC659_00260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HC659_00270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC659_00280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC659_00370	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HC659_00380	COG3853	Toxic anion resistance protein (TelA)
HC659_00390	COG1982	Orn Lys Arg decarboxylase major
HC659_00400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC659_00410	COG3870	Protein conserved in bacteria
HC659_00420	COG1728	Protein conserved in bacteria
HC659_00430	COG0470	DNA polymerase III
HC659_00440	COG1774	PSP1 C-terminal conserved region
HC659_00450	COG4467	Involved in initiation control of chromosome replication
HC659_00460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HC659_00470	COG2827	Endonuclease containing a URI domain
HC659_00480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC659_00490	COG2002	toxin-antitoxin pair type II binding
HC659_00500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC659_00500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC659_00510	COG0084	hydrolase, TatD family'
HC659_00520	COG3583	domain protein
HC659_00520	COG3584	3D domain protein
HC659_00530	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC659_00540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC659_00560	COG4466	Protein conserved in bacteria
HC659_00580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC659_00590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC659_00600	COG0251	oxidation-reduction process
HC659_00610	COG2088	sporulation resulting in formation of a cellular spore
HC659_00620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC659_00630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC659_00640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HC659_00650	COG0193	aminoacyl-tRNA hydrolase activity
HC659_00670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC659_00680	COG2002	toxin-antitoxin pair type II binding
HC659_00690	COG2244	polysaccharide biosynthetic process
HC659_00700	COG3956	TIGRFAM MazG family protein
HC659_00710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC659_00740	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HC659_00750	COG1098	S1 RNA binding domain
HC659_00780	COG2208	phosphoserine phosphatase activity
HC659_00790	COG2304	oxidoreductase activity
HC659_00800	COG0515	serine threonine protein kinase
HC659_00810	COG0037	tRNA processing
HC659_00830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC659_00840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HC659_00850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HC659_00860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC659_00870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC659_00880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC659_00890	COG0512	Glutamine amidotransferase of anthranilate synthase
HC659_00900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC659_00910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC659_00920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC659_00930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC659_00940	COG1396	sequence-specific DNA binding
HC659_00950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC659_00960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC659_01090	COG4463	regulation of RNA biosynthetic process
HC659_01100	COG3880	PFAM UvrB UvrC protein
HC659_01110	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HC659_01120	COG0542	response to heat
HC659_01130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC659_01140	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HC659_01150	COG4956	integral membrane protein (PIN domain superfamily)
HC659_01160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HC659_01170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HC659_01180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC659_01190	COG1045	serine acetyltransferase
HC659_01200	COG0215	cysteine-tRNA ligase activity
HC659_01210	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HC659_01220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC659_01230	COG3688	RNA-binding protein containing a PIN domain
HC659_01240	COG1595	DNA-templated transcription, initiation
HC659_01260	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC659_01270	COG0250	Participates in transcription elongation, termination and antitermination
HC659_01290	COG0081	regulation of translation
HC659_01300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC659_01320	COG2813	Specifically methylates the guanine in position
HC659_01330	COG0085	RNA polymerase activity
HC659_01340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC659_01350	COG1358	cellular component organization or biogenesis
HC659_01360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HC659_01370	COG0049	tRNA binding
HC659_01380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC659_01390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC659_01400	COG0596	Alpha beta hydrolase
HC659_01420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC659_01430	COG0088	Forms part of the polypeptide exit tunnel
HC659_01450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC659_01480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HC659_01490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC659_01510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC659_01520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC659_01540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC659_01560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC659_01570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC659_01580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HC659_01610	COG0200	Binds to the 23S rRNA
HC659_01620	COG0201	protein transport
HC659_01630	COG0563	adenylate kinase activity
HC659_01640	COG0024	Methionine aminopeptidase
HC659_01650	COG2163	COG2163 Ribosomal protein L14E L6E L27E
HC659_01670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC659_01680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HC659_01690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HC659_01700	COG0202	RNA polymerase activity
HC659_01710	COG0203	ribosomal protein L17
HC659_01720	COG1122	ATPase activity
HC659_01730	COG1122	ATPase activity
HC659_01740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC659_01750	COG0101	tRNA pseudouridine synthase activity
HC659_01760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC659_01770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HC659_01780	COG2226	methyltransferase
HC659_01800	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC659_01810	COG0489	protein tyrosine kinase activity
HC659_01830	COG2194	sulfuric ester hydrolase activity
HC659_01840	COG0726	polysaccharide deacetylase
HC659_02000	COG0659	secondary active sulfate transmembrane transporter activity
HC659_02010	COG0385	Bile acid
HC659_02020	COG2819	hydrolase of the alpha beta superfamily
HC659_02030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_02040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_02050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC659_02060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC659_02060	COG2207	Transcriptional regulator
HC659_02070	COG3876	Protein conserved in bacteria
HC659_02080	COG1472	Belongs to the glycosyl hydrolase 3 family
HC659_02090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC659_02100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_02100	COG1263	PTS System
HC659_02110	COG1737	Transcriptional regulator
HC659_02120	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HC659_02130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC659_02140	COG1683	Conserved Protein
HC659_02200	COG1595	DNA-templated transcription, initiation
HC659_02210	COG5662	AntiSigma factor
HC659_02220	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC659_02230	COG4856	YbbR-like protein
HC659_02240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC659_02250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC659_02260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC659_02270	COG2169	Transcriptional regulator
HC659_02280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC659_02290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC659_02300	COG3002	Belongs to the UPF0753 family
HC659_02310	COG0288	reversible hydration of carbon dioxide
HC659_02330	COG5609	conserved protein (DUF2294)
HC659_02340	COG0640	Transcriptional regulator
HC659_02350	COG2814	Major facilitator Superfamily
HC659_02360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC659_02380	COG0535	radical SAM domain protein
HC659_02390	COG1266	CAAX protease self-immunity
HC659_02400	COG1131	(ABC) transporter
HC659_02420	COG1413	lyase activity
HC659_02430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_02440	COG0596	Alpha beta hydrolase
HC659_02450	COG0745	RESPONSE REGULATOR receiver
HC659_02460	COG0642	Histidine kinase
HC659_02480	COG0515	serine threonine protein kinase
HC659_02510	COG1113	amino acid transport
HC659_02540	COG2602	Beta-lactamase
HC659_02550	COG2124	cytochrome p450
HC659_02570	COG0531	amino acid
HC659_02580	COG0584	glycerophosphoryl diester phosphodiesterase
HC659_02590	COG2271	Major facilitator Superfamily
HC659_02610	COG1846	Transcriptional regulator
HC659_02610	COG0456	acetyltransferase
HC659_02620	COG2271	Major facilitator Superfamily
HC659_02650	COG3409	Peptidoglycan-binding domain 1 protein
HC659_02660	COG0697	spore germination
HC659_02670	COG2207	Transcriptional regulator
HC659_02670	COG1917	Cupin 2, conserved barrel domain protein
HC659_02680	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HC659_02690	COG3591	Belongs to the peptidase S1B family
HC659_02710	COG0596	Alpha beta hydrolase
HC659_02720	COG1183	phosphatidylcholine synthase activity
HC659_02730	COG0586	Pfam SNARE associated Golgi protein
HC659_02740	COG0688	phosphatidylethanolamine metabolic process
HC659_02760	COG2312	Erythromycin esterase
HC659_02770	COG2207	Transcriptional regulator
HC659_02790	COG1301	dicarboxylic acid transport
HC659_02800	COG1263	PTS System
HC659_02800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_02800	COG2190	(PTS) system
HC659_02810	COG0363	glucosamine-6-phosphate deaminase activity
HC659_02820	COG2188	Transcriptional regulator
HC659_02840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC659_02850	COG0833	amino acid
HC659_02860	COG2040	homocysteine
HC659_02870	COG1115	amino acid carrier protein
HC659_02880	COG2066	Belongs to the glutaminase family
HC659_02890	COG4191	Histidine kinase
HC659_02900	COG0784	Response regulator, receiver
HC659_02910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC659_02920	COG1012	belongs to the aldehyde dehydrogenase family
HC659_02930	COG2271	Major facilitator Superfamily
HC659_02940	COG4948	Mandelate Racemase Muconate Lactonizing
HC659_02950	COG2186	Transcriptional regulator
HC659_02960	COG2721	sulfolactate sulfo-lyase activity
HC659_02970	COG3173	Aminoglycoside phosphotransferase
HC659_02990	COG0697	spore germination
HC659_03000	COG0745	RESPONSE REGULATOR receiver
HC659_03010	COG2205	protein histidine kinase activity
HC659_03020	COG1131	(ABC) transporter
HC659_03050	COG3773	Cell wall hydrolase
HC659_03060	COG2304	oxidoreductase activity
HC659_03080	COG3540	Alkaline phosphatase
HC659_03090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC659_03100	COG0805	protein transport
HC659_03110	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HC659_03120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC659_03130	COG0477	Major facilitator Superfamily
HC659_03140	COG1309	transcriptional regulator
HC659_03150	COG0252	asparaginase activity
HC659_03160	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC659_03170	COG1714	RDD family
HC659_03180	COG1405	negative regulation of cell septum assembly
HC659_03180	COG3012	SEC-C Motif Domain Protein
HC659_03190	COG3290	protein histidine kinase activity
HC659_03200	COG3279	Response regulator of the LytR AlgR family
HC659_03210	COG4555	ABC transporter
HC659_03220	COG1668	transmembrane transport
HC659_03230	COG0667	Aldo Keto reductase
HC659_03250	COG1595	DNA-templated transcription, initiation
HC659_03260	COG1595	DNA-templated transcription, initiation
HC659_03270	COG1876	peptidase activity
HC659_03280	COG0457	Tetratricopeptide repeat
HC659_03290	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_03300	COG0366	Alpha amylase catalytic
HC659_03310	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC659_03320	COG1121	(ABC) transporter
HC659_03330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC659_03340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC659_03350	COG2310	stress, protein
HC659_03360	COG2310	stress, protein
HC659_03370	COG2310	stress, protein
HC659_03380	COG0861	Integral membrane protein TerC family
HC659_03400	COG3853	Toxic anion resistance protein (TelA)
HC659_03410	COG0477	Major facilitator Superfamily
HC659_03420	COG2814	Major facilitator Superfamily
HC659_03430	COG0640	Transcriptional regulator
HC659_03440	COG0517	IMP dehydrogenase activity
HC659_03440	COG4175	Glycine betaine
HC659_03450	COG4176	ABC-type proline glycine betaine transport system permease component
HC659_03460	COG2113	Glycine betaine
HC659_03470	COG1473	amidohydrolase
HC659_03480	COG1288	antiporter activity
HC659_03500	COG0366	Alpha amylase catalytic
HC659_03510	COG0039	L-malate dehydrogenase activity
HC659_03520	COG1620	l-lactate permease
HC659_03530	COG2814	Major facilitator Superfamily
HC659_03540	COG1846	Transcriptional regulator
HC659_03550	COG1280	lysine exporter protein (LysE YggA)
HC659_03560	COG3403	YqcI/YcgG family
HC659_03570	COG1113	amino acid transport
HC659_03580	COG3665	Urea carboxylase-associated protein
HC659_03590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HC659_03600	COG1660	Displays ATPase and GTPase activities
HC659_03610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC659_03620	COG2226	methyltransferase
HC659_03630	COG0583	DNA-binding transcription factor activity
HC659_03640	COG3458	cephalosporin-C deacetylase activity
HC659_03650	COG3541	Predicted nucleotidyltransferase
HC659_03660	COG0506	proline dehydrogenase activity
HC659_03670	COG1012	belongs to the aldehyde dehydrogenase family
HC659_03680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC659_03690	COG2508	Transcriptional regulator
HC659_03700	COG3689	TIGRFAM TIGR03943 family protein
HC659_03710	COG0701	Predicted permease
HC659_03720	COG2267	carboxylic ester hydrolase activity
HC659_03730	COG0492	ferredoxin-NADP+ reductase activity
HC659_03740	COG1587	Uroporphyrinogen-III synthase
HC659_03740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC659_03750	COG2146	nitrite reductase [NAD(P)H] activity
HC659_03760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC659_03770	COG0243	molybdopterin cofactor binding
HC659_03780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC659_03790	COG2223	nitrite transmembrane transporter activity
HC659_03800	COG1469	GTP cyclohydrolase I activity
HC659_03810	COG1376	ErfK ybiS ycfS ynhG family protein
HC659_03830	COG0523	cobalamin synthesis protein
HC659_03840	COG0765	amino acid transport
HC659_03850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC659_03860	COG1714	RDD family
HC659_03880	COG2723	6-phospho-beta-galactosidase activity
HC659_03900	COG3209	COG3209 Rhs family protein
HC659_03910	COG0840	transmembrane signaling receptor activity
HC659_03910	COG3290	protein histidine kinase activity
HC659_03920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HC659_03930	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HC659_03940	COG1733	regulation of RNA biosynthetic process
HC659_03950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_03960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_03970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_03980	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC659_03990	COG2814	Major facilitator Superfamily
HC659_04010	COG0697	spore germination
HC659_04020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC659_04040	COG2364	Membrane
HC659_04050	COG1126	abc transporter atp-binding protein
HC659_04060	COG0765	amino acid transport
HC659_04070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC659_04080	COG0583	DNA-binding transcription factor activity
HC659_04090	COG0163	prenyltransferase activity
HC659_04100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC659_04120	COG0596	Alpha beta hydrolase
HC659_04130	COG3104	oligopeptide transport
HC659_04140	COG5434	Belongs to the glycosyl hydrolase 28 family
HC659_04160	COG0697	spore germination
HC659_04180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC659_04190	COG1136	(ABC) transporter
HC659_04200	COG0577	efflux transmembrane transporter activity
HC659_04210	COG0745	RESPONSE REGULATOR receiver
HC659_04220	COG5002	protein histidine kinase activity
HC659_04220	COG3850	Histidine kinase
HC659_04230	COG0457	Tetratricopeptide repeat
HC659_04250	COG0527	aspartate kinase activity
HC659_04260	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_04270	COG4605	iron ion homeostasis
HC659_04280	COG4604	ABC transporter, ATP-binding protein
HC659_04290	COG4607	ABC-type enterochelin transport system periplasmic component
HC659_04300	COG2814	Major facilitator Superfamily
HC659_04310	COG1309	transcriptional regulator
HC659_04320	COG0778	Nitroreductase
HC659_04330	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC659_04340	COG0640	Transcriptional regulator
HC659_04350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC659_04360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC659_04370	COG1012	belongs to the aldehyde dehydrogenase family
HC659_04380	COG4975	Glucose uptake
HC659_04390	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_04400	COG4549	nuclear export factor GLE1
HC659_04410	COG1276	copper resistance
HC659_04410	COG2372	response to copper ion
HC659_04420	COG1349	DNA-binding transcription factor activity
HC659_04440	COG2213	PTS system mannitol-specific
HC659_04450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC659_04460	COG0246	Mannitol dehydrogenase
HC659_04470	COG0473	3-isopropylmalate dehydrogenase activity
HC659_04490	COG0681	Belongs to the peptidase S26 family
HC659_04500	COG0412	Dienelactone hydrolase
HC659_04510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC659_04530	COG0561	phosphatase activity
HC659_04540	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HC659_04550	COG1914	H( )-stimulated, divalent metal cation uptake system
HC659_04560	COG4336	lyase activity
HC659_04570	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC659_04580	COG1984	allophanate hydrolase subunit 2
HC659_04590	COG1414	Transcriptional regulator
HC659_04600	COG2755	lipolytic protein G-D-S-L family
HC659_04620	COG2329	Antibiotic biosynthesis monooxygenase
HC659_04630	COG0768	penicillin binding
HC659_04640	COG4989	oxidoreductase activity
HC659_04650	COG3711	transcriptional antiterminator
HC659_04660	COG0318	PFAM AMP-dependent synthetase and ligase
HC659_04670	COG2226	methyltransferase
HC659_04680	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_04690	COG1917	Cupin 2, conserved barrel domain protein
HC659_04700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC659_04710	COG3871	stress protein (general stress protein 26)
HC659_04740	COG2814	Major facilitator Superfamily
HC659_04750	COG1522	sequence-specific DNA binding
HC659_04760	COG0551	DNA topoisomerase type I activity
HC659_04760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC659_04770	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HC659_04780	COG3706	GGDEF domain
HC659_04790	COG5298	Protein conserved in bacteria
HC659_04800	COG1215	transferase activity, transferring glycosyl groups
HC659_04820	COG0531	amino acid
HC659_04830	COG0494	nUDIX hydrolase
HC659_04840	COG0028	Belongs to the TPP enzyme family
HC659_04860	COG1914	H( )-stimulated, divalent metal cation uptake system
HC659_04870	COG2261	transglycosylase associated protein
HC659_04880	COG4876	unkown
HC659_04890	COG2217	Heavy metal translocating P-type atpase
HC659_04900	COG3729	General stress protein
HC659_04910	COG0662	Cupin 2, conserved barrel domain protein
HC659_04920	COG2329	Antibiotic biosynthesis monooxygenase
HC659_04930	COG3546	catalase activity
HC659_04940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HC659_04950	COG3290	protein histidine kinase activity
HC659_04960	COG4565	transcriptional regulatory protein
HC659_04970	COG1301	dicarboxylic acid transport
HC659_04980	COG0628	permease
HC659_04990	COG1131	(ABC) transporter
HC659_05000	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC659_05020	COG1960	acyl-CoA dehydrogenase activity
HC659_05050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC659_05060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_05070	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC659_05080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC659_05090	COG0513	Belongs to the DEAD box helicase family
HC659_05100	COG3402	PFAM membrane-flanked domain
HC659_05110	COG3428	Bacterial PH domain
HC659_05120	COG0705	Rhomboid family
HC659_05130	COG0736	holo-[acyl-carrier-protein] synthase activity
HC659_05140	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HC659_05150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC659_05160	COG0864	Transcriptional regulator
HC659_05170	COG2337	Toxic component of a toxin-antitoxin (TA) module
HC659_05180	COG1366	Belongs to the anti-sigma-factor antagonist family
HC659_05190	COG1366	Belongs to the anti-sigma-factor antagonist family
HC659_05200	COG2172	sigma factor antagonist activity
HC659_05210	COG2208	phosphoserine phosphatase activity
HC659_05220	COG1366	Belongs to the anti-sigma-factor antagonist family
HC659_05230	COG2172	sigma factor antagonist activity
HC659_05240	COG1191	sigma factor activity
HC659_05250	COG2208	phosphoserine phosphatase activity
HC659_05260	COG2183	response to ionizing radiation
HC659_05280	COG3091	SprT-like family
HC659_05360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC659_05380	COG5444	nuclease activity
HC659_05390	COG1476	TRANSCRIPTIONal
HC659_05410	COG3239	Fatty acid desaturase
HC659_05420	COG1278	Cold shock
HC659_05430	COG1329	Transcriptional regulator
HC659_05440	COG0697	spore germination
HC659_05450	COG2207	Transcriptional regulator
HC659_05450	COG1917	Cupin 2, conserved barrel domain protein
HC659_05460	COG0697	spore germination
HC659_05470	COG3708	Transcriptional regulator
HC659_05470	COG2207	Transcriptional regulator
HC659_05480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC659_05490	COG0477	Major facilitator Superfamily
HC659_05510	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HC659_05540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC659_05550	COG1309	transcriptional regulator
HC659_05560	COG0697	spore germination
HC659_05570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC659_05580	COG2030	dehydratase
HC659_05590	COG3545	Serine hydrolase
HC659_05600	COG1733	regulation of RNA biosynthetic process
HC659_05610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC659_05620	COG2814	Major facilitator Superfamily
HC659_05630	COG1309	transcriptional regulator
HC659_05650	COG0640	Transcriptional regulator
HC659_05660	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC659_05680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC659_05690	COG0697	spore germination
HC659_05700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC659_05710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC659_05720	COG0640	Transcriptional regulator
HC659_05730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC659_05740	COG4585	Histidine kinase
HC659_05750	COG2197	response regulator
HC659_05760	COG2409	Drug exporters of the RND superfamily
HC659_05770	COG0596	Alpha beta hydrolase
HC659_05780	COG1811	Na channel or pump
HC659_05790	COG4978	Transcriptional regulator
HC659_05790	COG0789	Transcriptional regulator
HC659_05800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC659_05810	COG0778	Nitroreductase
HC659_05820	COG0346	lactoylglutathione lyase activity
HC659_05830	COG2259	Doxx family
HC659_05840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_05880	COG2323	membrane
HC659_05890	COG2323	membrane
HC659_05900	COG0071	Belongs to the small heat shock protein (HSP20) family
HC659_05930	COG1309	transcriptional regulator
HC659_05950	COG0456	acetyltransferase
HC659_05970	COG1113	amino acid transport
HC659_05980	COG2318	DinB family
HC659_05990	COG1846	Transcriptional regulator
HC659_06000	COG2409	Drug exporters of the RND superfamily
HC659_06000	COG1033	growth of symbiont in host cell
HC659_06010	COG0778	Nitroreductase
HC659_06020	COG1846	Transcriptional regulator
HC659_06030	COG2814	Major facilitator Superfamily
HC659_06040	COG0730	response to heat
HC659_06050	COG1802	Transcriptional regulator
HC659_06060	COG1388	LysM domain
HC659_06060	COG3858	chitin binding
HC659_06070	COG1819	glycosyl
HC659_06090	COG1785	Belongs to the alkaline phosphatase family
HC659_06100	COG5646	InterPro IPR014922
HC659_06120	COG0454	-acetyltransferase
HC659_06130	COG1078	dGTPase activity
HC659_06140	COG1388	LysM domain
HC659_06150	COG2814	Major facilitator Superfamily
HC659_06160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC659_06170	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC659_06180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC659_06190	COG2723	6-phospho-beta-galactosidase activity
HC659_06200	COG2188	Transcriptional regulator
HC659_06210	COG1940	carbohydrate kinase activity
HC659_06220	COG1482	cell wall glycoprotein biosynthetic process
HC659_06230	COG4124	Belongs to the glycosyl hydrolase 26 family
HC659_06320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HC659_06330	COG0802	atpase or kinase
HC659_06340	COG1214	PFAM Peptidase M22, glycoprotease
HC659_06350	COG0456	acetyltransferase
HC659_06360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC659_06370	COG0488	(ABC) transporter
HC659_06380	COG0315	cyclic pyranopterin monophosphate synthase activity
HC659_06390	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HC659_06400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC659_06410	COG0805	protein transport
HC659_06430	COG1266	CAAX protease self-immunity
HC659_06450	COG0459	protein refolding
HC659_06460	COG3378	Phage plasmid primase P4 family
HC659_06480	COG0270	DNA (cytosine-5-)-methyltransferase activity
HC659_06490	COG0270	DNA (cytosine-5-)-methyltransferase activity
HC659_06510	COG1401	restriction endodeoxyribonuclease activity
HC659_06540	COG0457	Tetratricopeptide repeat
HC659_06550	COG1063	alcohol dehydrogenase
HC659_06560	COG2211	Major facilitator Superfamily
HC659_06570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC659_06580	COG1842	Phage shock protein A
HC659_06590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC659_06600	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HC659_06610	COG4260	virion core protein, lumpy skin disease virus
HC659_06630	COG2814	Major facilitator Superfamily
HC659_06640	COG1063	alcohol dehydrogenase
HC659_06650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC659_06660	COG0823	Involved in the tonB-independent uptake of proteins
HC659_06690	COG2267	carboxylic ester hydrolase activity
HC659_06710	COG2132	Multicopper oxidase
HC659_06720	COG1113	amino acid transport
HC659_06730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC659_06740	COG0714	Associated with various cellular activities
HC659_06750	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HC659_06760	COG1305	Transglutaminase-like
HC659_06770	COG0519	Catalyzes the synthesis of GMP from XMP
HC659_06770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC659_06780	COG2252	PERMEase
HC659_06790	COG3064	Membrane
HC659_06810	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HC659_06830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC659_06840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC659_06850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC659_06860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC659_06870	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC659_06880	COG0047	phosphoribosylformylglycinamidine synthase activity
HC659_06890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC659_06900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC659_06910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC659_06920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC659_06930	COG0138	bifunctional purine biosynthesis protein purh
HC659_06940	COG0151	Belongs to the GarS family
HC659_06950	COG1522	sequence-specific DNA binding
HC659_06960	COG0531	amino acid
HC659_06980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC659_06990	COG1470	cell adhesion involved in biofilm formation
HC659_07000	COG4496	protein, YerC YecD
HC659_07010	COG0069	glutamate synthase activity
HC659_07020	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HC659_07030	COG0210	DNA helicase
HC659_07040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC659_07050	COG4851	CamS sex pheromone cAM373 precursor
HC659_07060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC659_07070	COG1285	pathogenesis
HC659_07080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC659_07090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC659_07100	COG0154	amidase activity
HC659_07110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC659_07120	COG1309	transcriptional regulator
HC659_07130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC659_07140	COG1597	lipid kinase activity
HC659_07150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC659_07160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC659_07170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC659_07180	COG1002	Type II restriction enzyme, methylase subunits
HC659_07190	COG1061	Type III restriction enzyme res subunit
HC659_07200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC659_07240	COG5444	nuclease activity
HC659_07250	COG3391	amine dehydrogenase activity
HC659_07280	COG0457	Tetratricopeptide repeat
HC659_07300	COG0217	transcriptional regulatory protein
HC659_07320	COG1309	transcriptional regulator
HC659_07330	COG3631	Ketosteroid isomerase-related protein
HC659_07340	COG0702	epimerase
HC659_07370	COG3546	catalase activity
HC659_07380	COG0454	-acetyltransferase
HC659_07400	COG5578	integral membrane protein
HC659_07410	COG2972	Histidine kinase
HC659_07420	COG4753	response regulator
HC659_07420	COG2207	Transcriptional regulator
HC659_07430	COG1653	transport
HC659_07440	COG1175	transmembrane transport
HC659_07450	COG0395	ABC-type sugar transport system, permease component
HC659_07460	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC659_07470	COG2207	Transcriptional regulator
HC659_07480	COG2755	lipolytic protein G-D-S-L family
HC659_07500	COG5578	integral membrane protein
HC659_07510	COG3401	FG-GAP repeat protein
HC659_07520	COG3401	FG-GAP repeat protein
HC659_07530	COG2755	lipolytic protein G-D-S-L family
HC659_07540	COG1874	Beta-galactosidase
HC659_07560	COG1653	transport
HC659_07570	COG4209	transmembrane transport
HC659_07580	COG0395	ABC-type sugar transport system, permease component
HC659_07590	COG1486	melibiose metabolic process
HC659_07600	COG2323	membrane
HC659_07610	COG2329	Antibiotic biosynthesis monooxygenase
HC659_07620	COG0346	lactoylglutathione lyase activity
HC659_07650	COG5583	Uncharacterized small protein (DUF2292)
HC659_07660	COG0670	Belongs to the BI1 family
HC659_07670	COG0697	spore germination
HC659_07680	COG1846	Transcriptional regulator
HC659_07690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC659_07710	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC659_07710	COG2124	cytochrome p450
HC659_07720	COG1368	sulfuric ester hydrolase activity
HC659_07730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC659_07740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC659_07750	COG1442	glycosyl transferase family 8
HC659_07760	COG1216	Glycosyl transferase, family 2
HC659_07770	COG1442	glycosyl transferase family 8
HC659_07780	COG2223	nitrite transmembrane transporter activity
HC659_07790	COG1011	Hydrolase
HC659_07800	COG0531	amino acid
HC659_07810	COG1012	belongs to the aldehyde dehydrogenase family
HC659_07820	COG0840	transmembrane signaling receptor activity
HC659_07830	COG0488	(ABC) transporter
HC659_07850	COG0789	Transcriptional regulator
HC659_07860	COG2814	Major facilitator Superfamily
HC659_07890	COG0488	(ABC) transporter
HC659_07900	COG0513	Belongs to the DEAD box helicase family
HC659_07910	COG0456	acetyltransferase
HC659_07920	COG2130	NADP-dependent
HC659_07940	COG2211	Major facilitator Superfamily
HC659_07950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HC659_07960	COG1120	ATPase activity
HC659_07970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_07980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_07990	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC659_08020	COG3866	Pectate lyase
HC659_08030	COG0471	metal ion transport
HC659_08040	COG3290	protein histidine kinase activity
HC659_08050	COG4565	transcriptional regulatory protein
HC659_08060	COG3181	Tripartite tricarboxylate transporter family receptor
HC659_08070	COG2851	Citrate transporter
HC659_08080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC659_08090	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HC659_08100	COG1254	Belongs to the acylphosphatase family
HC659_08110	COG2258	MOSC domain
HC659_08150	COG0024	Methionine aminopeptidase
HC659_08160	COG1263	PTS System
HC659_08160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_08170	COG1368	sulfuric ester hydrolase activity
HC659_08190	COG1115	amino acid carrier protein
HC659_08200	COG0531	amino acid
HC659_08230	COG0697	spore germination
HC659_08240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_08240	COG1263	PTS System
HC659_08250	COG0366	Alpha amylase catalytic
HC659_08260	COG2188	Transcriptional regulator
HC659_08270	COG0778	Nitroreductase
HC659_08280	COG0737	Belongs to the 5'-nucleotidase family
HC659_08290	COG0693	protein deglycase activity
HC659_08300	COG2814	Major facilitator Superfamily
HC659_08310	COG4840	Belongs to the UPF0435 family
HC659_08320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC659_08330	COG4980	gas vesicle protein
HC659_08340	COG1295	ribonuclease BN
HC659_08350	COG0477	Major facilitator Superfamily
HC659_08360	COG0387	Pfam Sodium calcium exchanger
HC659_08380	COG0668	transmembrane transport
HC659_08390	COG0535	radical SAM domain protein
HC659_08410	COG0726	polysaccharide deacetylase
HC659_08420	COG2084	Dehydrogenase
HC659_08430	COG0598	Magnesium transport protein CorA
HC659_08440	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC659_08450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC659_08470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC659_08480	COG4637	Psort location Cytoplasmic, score
HC659_08500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC659_08510	COG0022	dehydrogenase e1 component
HC659_08520	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC659_08530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC659_08540	COG3284	Transcriptional regulator
HC659_08560	COG1742	UPF0060 membrane protein
HC659_08610	COG4842	Belongs to the WXG100 family
HC659_08620	COG1486	melibiose metabolic process
HC659_08630	COG1737	Transcriptional regulator
HC659_08640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_08640	COG1263	PTS System
HC659_08650	COG1132	(ABC) transporter
HC659_08660	COG1132	(ABC) transporter
HC659_08670	COG2259	Doxx family
HC659_08680	COG2514	catechol 2,3-dioxygenase activity
HC659_08690	COG1917	Cupin 2, conserved barrel domain protein
HC659_08690	COG4977	sequence-specific DNA binding
HC659_08700	COG2814	Major facilitator Superfamily
HC659_08710	COG1082	Xylose isomerase domain protein TIM barrel
HC659_08720	COG0673	inositol 2-dehydrogenase activity
HC659_08730	COG4585	Histidine kinase
HC659_08740	COG2197	response regulator
HC659_08750	COG1131	(ABC) transporter
HC659_08760	COG1511	domain protein
HC659_08760	COG0842	Transport permease protein
HC659_08770	COG0842	Transport permease protein
HC659_08780	COG1695	Transcriptional regulator
HC659_08790	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC659_08800	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HC659_08810	COG1309	transcriptional regulator
HC659_08820	COG2814	Major facilitator Superfamily
HC659_08830	COG2318	DinB family
HC659_08840	COG2814	Major facilitator Superfamily
HC659_08850	COG1846	Transcriptional regulator
HC659_08860	COG0392	lysyltransferase activity
HC659_08860	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC659_08870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC659_08880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_08890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_08900	COG0384	phenazine biosynthesis protein PhzF
HC659_08910	COG0778	Nitroreductase
HC659_08940	COG1090	epimerase
HC659_08950	COG2137	regulation of response to DNA damage stimulus
HC659_08970	COG2814	Major facilitator Superfamily
HC659_09000	COG3103	Sh3 type 3 domain protein
HC659_09010	COG5658	integral membrane protein
HC659_09020	COG0596	Alpha beta hydrolase
HC659_09030	COG0463	Glycosyl transferase, family 2
HC659_09040	COG4485	Bacterial membrane protein, YfhO
HC659_09050	COG1988	membrane-bound metal-dependent
HC659_09060	COG1194	a g-specific adenine glycosylase
HC659_09080	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_09110	COG3557	Belongs to the UPF0374 family
HC659_09120	COG1132	(ABC) transporter
HC659_09130	COG4129	membrane
HC659_09140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC659_09150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC659_09160	COG0735	belongs to the Fur family
HC659_09380	COG4326	sporulation control protein
HC659_09400	COG5577	PFAM Coat F domain
HC659_09410	COG3340	Belongs to the peptidase S51 family
HC659_09420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HC659_09430	COG0277	FAD linked oxidase domain protein
HC659_09450	COG0753	catalase activity
HC659_09460	COG1116	anion transmembrane transporter activity
HC659_09470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC659_09480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC659_09490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC659_09510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC659_09530	COG1476	TRANSCRIPTIONal
HC659_09550	COG3382	B3 4 domain protein
HC659_09560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC659_09580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC659_09590	COG0789	Transcriptional regulator
HC659_09600	COG1664	Polymer-forming cytoskeletal
HC659_09610	COG1664	Polymer-forming cytoskeletal
HC659_09620	COG2766	serine protein kinase
HC659_09630	COG2718	Belongs to the UPF0229 family
HC659_09640	COG1846	Transcriptional regulator
HC659_09650	COG1566	PFAM secretion protein HlyD family protein
HC659_09660	COG2814	Major facilitator Superfamily
HC659_09670	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC659_09710	COG1725	Transcriptional regulator
HC659_09720	COG1131	(ABC) transporter
HC659_09730	COG1131	(ABC) transporter
HC659_09740	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC659_09750	COG1278	Cold shock
HC659_09760	COG1464	Belongs to the NlpA lipoprotein family
HC659_09770	COG3706	GGDEF domain
HC659_09780	COG1823	symporter activity
HC659_09820	COG5577	PFAM Coat F domain
HC659_09830	COG1525	nuclease
HC659_09830	COG4085	toxin activity
HC659_09830	COG0737	Belongs to the 5'-nucleotidase family
HC659_09840	COG3764	Sortase (surface protein transpeptidase)
HC659_09850	COG0564	pseudouridine synthase activity
HC659_09870	COG0517	IMP dehydrogenase activity
HC659_09880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC659_09890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC659_09890	COG3153	acetyltransferase
HC659_09910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC659_09920	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HC659_09930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC659_09940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC659_09950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC659_09960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC659_09970	COG2203	Gaf domain
HC659_09970	COG4585	Histidine kinase
HC659_09980	COG2197	response regulator
HC659_09990	COG0431	NADPH-dependent FMN reductase
HC659_10020	COG1388	LysM domain
HC659_10020	COG0791	NLP P60 protein
HC659_10030	COG1959	2 iron, 2 sulfur cluster binding
HC659_10040	COG0668	transmembrane transport
HC659_10050	COG2719	SpoVR family
HC659_10060	COG1785	Belongs to the alkaline phosphatase family
HC659_10070	COG0791	NLP P60 protein
HC659_10070	COG1388	LysM domain
HC659_10080	COG0583	DNA-binding transcription factor activity
HC659_10090	COG0372	Belongs to the citrate synthase family
HC659_10100	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_10110	COG0531	amino acid
HC659_10120	COG0733	neurotransmitter:sodium symporter activity
HC659_10130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC659_10140	COG0456	acetyltransferase
HC659_10170	COG1595	DNA-templated transcription, initiation
HC659_10180	COG0667	Aldo Keto reductase
HC659_10190	COG0204	Acyl-transferase
HC659_10200	COG1253	flavin adenine dinucleotide binding
HC659_10210	COG0789	Transcriptional regulator
HC659_10220	COG0436	Aminotransferase
HC659_10230	COG1253	flavin adenine dinucleotide binding
HC659_10240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC659_10250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC659_10260	COG0584	glycerophosphoryl diester phosphodiesterase
HC659_10280	COG0668	transmembrane transport
HC659_10290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC659_10300	COG0726	polysaccharide deacetylase
HC659_10310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC659_10320	COG1757	Na H antiporter
HC659_10330	COG0589	response to stress
HC659_10350	COG1132	(ABC) transporter
HC659_10360	COG1132	(ABC) transporter
HC659_10370	COG0702	epimerase
HC659_10410	COG0189	ligase activity
HC659_10420	COG0189	ligase activity
HC659_10430	COG4399	Belongs to the UPF0754 family
HC659_10440	COG3679	Belongs to the UPF0342 family
HC659_10450	COG4335	DNA alkylation repair
HC659_10460	COG0561	phosphatase activity
HC659_10470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC659_10480	COG0475	glutathione-regulated potassium exporter activity
HC659_10490	COG0490	domain, Protein
HC659_10510	COG1024	Enoyl-CoA hydratase
HC659_10530	COG4152	abc transporter atp-binding protein
HC659_10540	COG1668	transmembrane transport
HC659_10550	COG0420	3'-5' exonuclease activity
HC659_10560	COG4717	serine-type aminopeptidase activity
HC659_10570	COG3481	metal-dependent phosphohydrolase, HD sub domain
HC659_10590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC659_10630	COG1846	Transcriptional regulator
HC659_10640	COG4980	gas vesicle protein
HC659_10670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HC659_10680	COG0537	adenosine 5'-monophosphoramidase activity
HC659_10690	COG1131	(ABC) transporter
HC659_10700	COG4473	ABC transporter
HC659_10720	COG1473	amidohydrolase
HC659_10730	COG3069	C4-dicarboxylate transmembrane transporter activity
HC659_10740	COG2329	Antibiotic biosynthesis monooxygenase
HC659_10750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC659_10760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HC659_10790	COG1309	transcriptional regulator
HC659_10800	COG1511	domain protein
HC659_10810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC659_10820	COG4377	Putative membrane peptidase family (DUF2324)
HC659_10840	COG1363	Peptidase, m42
HC659_10850	COG4405	Protein conserved in bacteria
HC659_10860	COG1301	dicarboxylic acid transport
HC659_10880	COG1234	tRNA 3'-trailer cleavage
HC659_10890	COG0095	Lipoate-protein ligase
HC659_10900	COG0702	epimerase
HC659_10910	COG0318	PFAM AMP-dependent synthetase and ligase
HC659_10930	COG0501	Belongs to the peptidase M48B family
HC659_10960	COG0456	acetyltransferase
HC659_10970	COG0604	alcohol dehydrogenase
HC659_10980	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC659_10990	COG0406	alpha-ribazole phosphatase activity
HC659_11000	COG0183	Belongs to the thiolase family
HC659_11010	COG0318	PFAM AMP-dependent synthetase and ligase
HC659_11020	COG1268	BioY protein
HC659_11030	COG0840	transmembrane signaling receptor activity
HC659_11040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC659_11040	COG0723	plastoquinol--plastocyanin reductase activity
HC659_11050	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_11070	COG4903	ComK protein
HC659_11080	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_11100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC659_11130	COG0398	Pfam SNARE associated Golgi protein
HC659_11140	COG0681	Belongs to the peptidase S26 family
HC659_11150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC659_11160	COG1846	Transcriptional regulator
HC659_11170	COG0738	Major facilitator superfamily
HC659_11180	COG0673	inositol 2-dehydrogenase activity
HC659_11190	COG0561	phosphatase activity
HC659_11200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC659_11210	COG1609	Transcriptional regulator
HC659_11220	COG3180	Ammonia monooxygenase
HC659_11230	COG2814	Major facilitator Superfamily
HC659_11230	COG0477	Major facilitator Superfamily
HC659_11240	COG4533	DNA binding
HC659_11260	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HC659_11270	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HC659_11280	COG1074	ATP-dependent DNA helicase activity
HC659_11290	COG0420	3'-5' exonuclease activity
HC659_11300	COG0419	ATPase involved in DNA repair
HC659_11310	COG1403	HNH endonuclease
HC659_11390	COG5337	Spore coat protein CotH
HC659_11400	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC659_11420	COG1404	Belongs to the peptidase S8 family
HC659_11440	COG0367	asparagine synthase
HC659_11450	COG2318	DinB family
HC659_11460	COG1562	ergosterol biosynthetic process
HC659_11470	COG0534	Mate efflux family protein
HC659_11480	COG2207	Transcriptional regulator
HC659_11480	COG1917	Cupin 2, conserved barrel domain protein
HC659_11490	COG1609	Transcriptional regulator
HC659_11500	COG0673	inositol 2-dehydrogenase activity
HC659_11510	COG2318	DinB family
HC659_11520	COG1279	arginine transmembrane transporter activity
HC659_11530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC659_11540	COG1357	PFAM Pentapeptide repeats (8 copies)
HC659_11550	COG2267	carboxylic ester hydrolase activity
HC659_11560	COG0529	Catalyzes the synthesis of activated sulfate
HC659_11570	COG2046	Belongs to the sulfate adenylyltransferase family
HC659_11580	COG0175	sulfate reduction
HC659_11590	COG2045	Belongs to the ComB family
HC659_11600	COG1809	phosphosulfolactate synthase activity
HC659_11610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC659_11620	COG4948	Mandelate Racemase Muconate Lactonizing
HC659_11630	COG2814	Major facilitator Superfamily
HC659_11640	COG0454	-acetyltransferase
HC659_11650	COG2153	protein acetylation
HC659_11660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HC659_11660	COG0646	methionine synthase
HC659_11670	COG1666	GTP binding
HC659_11680	COG2996	Protein conserved in bacteria
HC659_11720	COG1695	Transcriptional regulator
HC659_11750	COG3227	Zinc metalloprotease (Elastase)
HC659_11760	COG1307	EDD domain protein, DegV family
HC659_11770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC659_11800	COG0561	phosphatase activity
HC659_11810	COG1073	alpha beta
HC659_11820	COG2151	metal-sulfur cluster biosynthetic enzyme
HC659_11840	COG0277	FAD linked oxidase domain protein
HC659_11850	COG2271	Major facilitator Superfamily
HC659_11860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC659_11870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HC659_11890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC659_11900	COG0505	Belongs to the CarA family
HC659_11910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC659_11920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HC659_11950	COG2267	carboxylic ester hydrolase activity
HC659_11970	COG1744	ABC transporter substrate-binding protein PnrA-like
HC659_12000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC659_12010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC659_12020	COG5504	Zn-dependent protease
HC659_12030	COG0444	Belongs to the ABC transporter superfamily
HC659_12040	COG4608	Belongs to the ABC transporter superfamily
HC659_12060	COG0601	transmembrane transport
HC659_12070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC659_12090	COG0180	Tryptophanyl-tRNA synthetase
HC659_12100	COG4166	transmembrane transport
HC659_12110	COG0601	transmembrane transport
HC659_12120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC659_12130	COG0444	Belongs to the ABC transporter superfamily
HC659_12140	COG4608	Belongs to the ABC transporter superfamily
HC659_12150	COG2814	Major facilitator Superfamily
HC659_12160	COG0456	acetyltransferase
HC659_12170	COG1393	Belongs to the ArsC family
HC659_12180	COG0861	Integral membrane protein TerC family
HC659_12190	COG4862	establishment of competence for transformation
HC659_12200	COG4469	Competence protein
HC659_12210	COG1164	Oligoendopeptidase f
HC659_12250	COG2346	COG2346, Truncated hemoglobins
HC659_12260	COG0741	lytic transglycosylase activity
HC659_12270	COG4116	CYTH
HC659_12290	COG2357	RelA SpoT domain protein
HC659_12300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC659_12310	COG0564	pseudouridine synthase activity
HC659_12320	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC659_12330	COG0475	glutathione-regulated potassium exporter activity
HC659_12330	COG0569	domain protein
HC659_12340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HC659_12350	COG0352	thiamine-phosphate diphosphorylase activity
HC659_12360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC659_12370	COG2104	thiamine diphosphate biosynthetic process
HC659_12380	COG2022	thiamine diphosphate biosynthetic process
HC659_12390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC659_12400	COG0351	phosphomethylpyrimidine kinase
HC659_12410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC659_12520	COG0210	DNA helicase
HC659_12540	COG2153	protein acetylation
HC659_12550	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC659_12560	COG2382	esterase
HC659_12570	COG0626	cystathionine gamma-synthase activity
HC659_12580	COG0626	cystathionine gamma-synthase activity
HC659_12590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC659_12600	COG5505	Protein of unknown function (DUF819)
HC659_12640	COG5444	nuclease activity
HC659_12690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC659_12700	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_12720	COG3711	transcriptional antiterminator
HC659_12720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC659_12730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC659_12730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC659_12730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC659_12740	COG1482	cell wall glycoprotein biosynthetic process
HC659_12760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC659_12780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC659_12810	COG0109	protoheme IX farnesyltransferase activity
HC659_12850	COG5504	Zn-dependent protease
HC659_12860	COG2205	protein histidine kinase activity
HC659_12880	COG3383	formate dehydrogenase (NAD+) activity
HC659_12890	COG2427	Protein of unknown function (DUF1641)
HC659_12910	COG1051	belongs to the nudix hydrolase family
HC659_12930	COG2124	cytochrome p450
HC659_12940	COG1819	glycosyl
HC659_12960	COG1587	Uroporphyrinogen-III synthase
HC659_12970	COG0390	transport system, permease component
HC659_12980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC659_12990	COG0697	spore germination
HC659_13000	COG4297	protein containing double-stranded beta helix domain
HC659_13020	COG1252	NADH dehydrogenase
HC659_13030	COG1904	glucuronate isomerase
HC659_13040	COG2211	Major facilitator Superfamily
HC659_13050	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HC659_13060	COG1063	alcohol dehydrogenase
HC659_13070	COG1312	Catalyzes the dehydration of D-mannonate
HC659_13080	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_13090	COG2271	Major facilitator Superfamily
HC659_13100	COG1609	Transcriptional regulator
HC659_13110	COG0246	Mannitol dehydrogenase
HC659_13120	COG2721	sulfolactate sulfo-lyase activity
HC659_13130	COG0730	response to heat
HC659_13140	COG2318	DinB family
HC659_13150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC659_13160	COG0457	Tetratricopeptide repeat
HC659_13180	COG2350	Protein conserved in bacteria
HC659_13190	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC659_13190	COG3409	Peptidoglycan-binding domain 1 protein
HC659_13190	COG1388	LysM domain
HC659_13210	COG4195	phage-related replication protein
HC659_13220	COG3546	catalase activity
HC659_13230	COG2856	Zn peptidase
HC659_13240	COG1396	sequence-specific DNA binding
HC659_13260	COG1522	sequence-specific DNA binding
HC659_13270	COG1484	DNA-dependent DNA replication
HC659_13310	COG1595	DNA-templated transcription, initiation
HC659_13320	COG3728	DNA packaging
HC659_13320	COG5484	DNA packaging
HC659_13330	COG1783	phage Terminase large subunit
HC659_13340	COG5518	Phage portal protein
HC659_13350	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC659_13360	COG4653	Phage capsid family
HC659_13450	COG3953	SLT domain
HC659_13450	COG5412	phage tail tape measure protein
HC659_13460	COG1652	LysM domain
HC659_13470	COG4193	domain, Protein
HC659_13490	COG3628	GPW Gp25 family protein
HC659_13500	COG3299	homolog of phage Mu protein gp47
HC659_13510	COG3778	Protein conserved in bacteria
HC659_13590	COG3409	Peptidoglycan-binding domain 1 protein
HC659_13590	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC659_13630	COG0306	phosphate transporter
HC659_13640	COG1392	Phosphate transport regulator
HC659_13650	COG0531	amino acid
HC659_13660	COG0346	lactoylglutathione lyase activity
HC659_13670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC659_13680	COG0463	Glycosyl transferase, family 2
HC659_13690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC659_13700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC659_13710	COG2362	D-Aminopeptidase
HC659_13720	COG0601	transmembrane transport
HC659_13730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC659_13740	COG0444	Belongs to the ABC transporter superfamily
HC659_13750	COG4166	transmembrane transport
HC659_13760	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC659_13770	COG4948	Mandelate Racemase Muconate Lactonizing
HC659_13780	COG0791	NLP P60 protein
HC659_13790	COG4608	Belongs to the ABC transporter superfamily
HC659_13800	COG2706	6-phosphogluconolactonase activity
HC659_13810	COG1834	amidinotransferase
HC659_13820	COG1607	acyl-coa hydrolase
HC659_13830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC659_13830	COG1017	nitric oxide dioxygenase activity
HC659_13850	COG2323	membrane
HC659_13860	COG2318	DinB family
HC659_13870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC659_13880	COG2076	Multidrug Resistance protein
HC659_13890	COG2076	Multidrug Resistance protein
HC659_13900	COG0788	formyltetrahydrofolate deformylase activity
HC659_13910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC659_13920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HC659_13930	COG1764	response to oxidative stress
HC659_13940	COG1846	Transcriptional regulator
HC659_13950	COG1764	response to oxidative stress
HC659_13970	COG0590	tRNA wobble adenosine to inosine editing
HC659_13980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC659_13990	COG1404	Belongs to the peptidase S8 family
HC659_14000	COG1366	Belongs to the anti-sigma-factor antagonist family
HC659_14010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC659_14020	COG1122	ATPase activity
HC659_14030	COG4721	ABC-type cobalt transport system, permease component
HC659_14050	COG0745	RESPONSE REGULATOR receiver
HC659_14060	COG5002	protein histidine kinase activity
HC659_14060	COG3850	Histidine kinase
HC659_14070	COG3212	peptidase
HC659_14080	COG3212	peptidase
HC659_14100	COG2239	Acts as a magnesium transporter
HC659_14110	COG0789	Transcriptional regulator
HC659_14140	COG1846	Transcriptional regulator
HC659_14150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC659_14160	COG0726	polysaccharide deacetylase
HC659_14170	COG1408	metallophosphoesterase
HC659_14190	COG0463	Glycosyl transferase, family 2
HC659_14200	COG1793	dna ligase
HC659_14200	COG3285	dna ligase
HC659_14210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HC659_14220	COG5001	Diguanylate cyclase
HC659_14220	COG3300	MHYT domain
HC659_14230	COG0586	Pfam SNARE associated Golgi protein
HC659_14240	COG0861	Integral membrane protein TerC family
HC659_14250	COG1191	sigma factor activity
HC659_14290	COG0501	Belongs to the peptidase M48B family
HC659_14300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC659_14330	COG3594	Acyltransferase
HC659_14340	COG5002	protein histidine kinase activity
HC659_14350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC659_14360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HC659_14370	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HC659_14380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC659_14390	COG0436	Aminotransferase
HC659_14400	COG1850	ribulose-bisphosphate carboxylase activity
HC659_14410	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HC659_14420	COG0235	Class ii aldolase
HC659_14430	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HC659_14440	COG3339	Conserved Protein
HC659_14470	COG3852	Histidine kinase
HC659_14480	COG1846	Transcriptional regulator
HC659_14490	COG1360	Flagellar Motor Protein
HC659_14500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC659_14510	COG0542	response to heat
HC659_14520	COG3949	Membrane
HC659_14530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HC659_14540	COG0720	synthase
HC659_14550	COG0602	queuosine metabolic process
HC659_14560	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HC659_14570	COG1733	regulation of RNA biosynthetic process
HC659_14580	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_14590	COG4641	Protein conserved in bacteria
HC659_14590	COG1388	LysM domain
HC659_14600	COG1388	LysM domain
HC659_14610	COG3858	chitin binding
HC659_14630	COG4873	Protein conserved in bacteria
HC659_14650	COG3773	Cell wall hydrolase
HC659_14660	COG2244	polysaccharide biosynthetic process
HC659_14670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_14680	COG2217	Heavy metal translocating P-type atpase
HC659_14700	COG0006	proline dipeptidase activity
HC659_14710	COG1609	Transcriptional regulator
HC659_14720	COG3711	transcriptional antiterminator
HC659_14730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_14730	COG1263	PTS System
HC659_14730	COG2190	(PTS) system
HC659_14740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC659_14750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC659_14770	COG1533	DNA photolyase activity
HC659_14780	COG0456	acetyltransferase
HC659_14790	COG0840	transmembrane signaling receptor activity
HC659_14800	COG2084	Dehydrogenase
HC659_14810	COG2340	Cysteine-rich secretory protein family
HC659_14820	COG0768	penicillin binding
HC659_14830	COG4191	Histidine kinase
HC659_14840	COG0436	Aminotransferase
HC659_14860	COG0784	Response regulator, receiver
HC659_14860	COG0835	chemotaxis
HC659_14880	COG2814	Major facilitator Superfamily
HC659_14890	COG1376	ErfK ybiS ycfS ynhG family protein
HC659_14900	COG1408	metallophosphoesterase
HC659_14910	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_14920	COG2200	EAL domain
HC659_14950	COG4703	Protein of unknown function (DUF1797)
HC659_14960	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HC659_14980	COG0517	IMP dehydrogenase activity
HC659_14990	COG0583	DNA-binding transcription factor activity
HC659_15000	COG0716	FMN binding
HC659_15020	COG0716	FMN binding
HC659_15030	COG2171	N-acyltransferase activity
HC659_15040	COG1473	amidohydrolase
HC659_15060	COG0668	transmembrane transport
HC659_15070	COG0450	alkyl hydroperoxide reductase
HC659_15080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_15110	COG0746	molybdenum cofactor guanylyltransferase activity
HC659_15120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC659_15130	COG0303	'Molybdopterin
HC659_15140	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC659_15150	COG0314	molybdopterin synthase activity
HC659_15160	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HC659_15170	COG1132	(ABC) transporter
HC659_15180	COG1132	(ABC) transporter
HC659_15200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC659_15210	COG1136	(ABC) transporter
HC659_15220	COG0577	efflux transmembrane transporter activity
HC659_15230	COG1349	DNA-binding transcription factor activity
HC659_15240	COG1105	Belongs to the carbohydrate kinase PfkB family
HC659_15250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC659_15250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC659_15250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC659_15260	COG0681	Belongs to the peptidase S26 family
HC659_15280	COG0488	(ABC) transporter
HC659_15290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC659_15300	COG2309	aminopeptidase activity
HC659_15310	COG1077	Cell shape determining protein MreB Mrl
HC659_15320	COG2002	toxin-antitoxin pair type II binding
HC659_15330	COG3852	Histidine kinase
HC659_15340	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HC659_15340	COG2105	PFAM AIG2 family protein
HC659_15350	COG0569	domain protein
HC659_15360	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC659_15370	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC659_15390	COG0561	phosphatase activity
HC659_15400	COG0242	peptide deformylase activity
HC659_15410	COG0497	DNA recombination
HC659_15420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC659_15430	COG0022	dehydrogenase e1 component
HC659_15440	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC659_15450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC659_15460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_15500	COG1982	Orn Lys Arg decarboxylase major
HC659_15510	COG4476	Belongs to the UPF0223 family
HC659_15520	COG4493	Belongs to the UPF0637 family
HC659_15540	COG0483	inositol monophosphate 1-phosphatase activity
HC659_15560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HC659_15600	COG1595	DNA-templated transcription, initiation
HC659_15660	COG4896	Protein conserved in bacteria
HC659_15680	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HC659_15690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC659_15700	COG2066	Belongs to the glutaminase family
HC659_15710	COG4838	Belongs to the UPF0358 family
HC659_15720	COG0772	Belongs to the SEDS family
HC659_15730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HC659_15740	COG1612	heme a metabolic process
HC659_15750	COG0109	protoheme IX farnesyltransferase activity
HC659_15760	COG2010	Cytochrome c
HC659_15760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC659_15770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC659_15780	COG1845	cytochrome c oxidase, subunit III
HC659_15790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC659_15800	COG3336	cytochrome c oxidase
HC659_15820	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HC659_15830	COG2340	Cysteine-rich secretory protein family
HC659_15860	COG3679	Belongs to the UPF0342 family
HC659_15870	COG4471	UPF0298 protein
HC659_15890	COG0742	ribosomal rna small subunit methyltransferase
HC659_15900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC659_15910	COG3314	Sporulation integral membrane protein YlbJ
HC659_15920	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC659_15930	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC659_15940	COG1323	Belongs to the UPF0348 family
HC659_15960	COG1399	metal-binding, possibly nucleic acid-binding protein
HC659_15990	COG0454	-acetyltransferase
HC659_16000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC659_16010	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HC659_16020	COG2001	Belongs to the MraZ family
HC659_16030	COG0275	rRNA processing
HC659_16040	COG4839	cell division protein FtsL
HC659_16060	COG0768	penicillin binding
HC659_16070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC659_16080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC659_16090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC659_16100	COG0772	Belongs to the SEDS family
HC659_16110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC659_16120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC659_16130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HC659_16140	COG3879	Bacterial protein of unknown function (DUF881)
HC659_16150	COG3879	Bacterial protein of unknown function (DUF881)
HC659_16160	COG3856	small basic protein
HC659_16170	COG0849	cell division
HC659_16180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC659_16190	COG1404	Belongs to the peptidase S8 family
HC659_16190	COG4412	M6 family metalloprotease domain protein
HC659_16210	COG1191	sigma factor activity
HC659_16220	COG1191	sigma factor activity
HC659_16230	COG1119	ATPase activity
HC659_16240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC659_16250	COG1873	PFAM PRC-barrel domain
HC659_16270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC659_16280	COG1799	cell septum assembly
HC659_16290	COG0762	integral membrane protein
HC659_16300	COG2302	S4 RNA-binding domain
HC659_16310	COG3599	regulation of cell shape
HC659_16320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC659_16330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC659_16340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC659_16350	COG0564	pseudouridine synthase activity
HC659_16360	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HC659_16370	COG2233	PERMEase
HC659_16380	COG0540	Belongs to the ATCase OTCase family
HC659_16390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC659_16400	COG0505	Belongs to the CarA family
HC659_16410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC659_16420	COG0543	2 iron, 2 sulfur cluster binding
HC659_16430	COG0167	dihydroorotate dehydrogenase activity
HC659_16440	COG0284	orotidine-5'-phosphate decarboxylase activity
HC659_16450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC659_16460	COG0175	sulfate reduction
HC659_16470	COG0306	phosphate transporter
HC659_16480	COG2046	Belongs to the sulfate adenylyltransferase family
HC659_16490	COG0529	Catalyzes the synthesis of activated sulfate
HC659_16500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC659_16510	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HC659_16520	COG1648	precorrin-2 dehydrogenase activity
HC659_16530	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HC659_16540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC659_16550	COG1561	YicC-like family, N-terminal region
HC659_16570	COG0194	GDP metabolic process
HC659_16580	COG1758	RNA polymerase activity
HC659_16590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC659_16600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC659_16610	COG0242	peptide deformylase activity
HC659_16620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC659_16630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC659_16630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HC659_16640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC659_16650	COG0631	protein serine/threonine phosphatase activity
HC659_16660	COG0515	serine threonine protein kinase
HC659_16660	COG2815	serine threonine protein kinase
HC659_16670	COG1162	GTPase activity
HC659_16680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC659_16690	COG1564	THIamine pyrophosphokinase
HC659_16700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC659_16710	COG1302	Protein conserved in bacteria
HC659_16720	COG1461	Dihydroxyacetone kinase
HC659_16730	COG1760	l-serine dehydratase
HC659_16740	COG1760	l-serine dehydratase
HC659_16750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC659_16760	COG2050	protein possibly involved in aromatic compounds catabolism
HC659_16760	COG1349	DNA-binding transcription factor activity
HC659_16770	COG0416	fatty acid biosynthetic process
HC659_16780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC659_16790	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_16810	COG0571	ribonuclease III activity
HC659_16820	COG1196	nuclear chromosome segregation
HC659_16830	COG0552	protein localization to endoplasmic reticulum
HC659_16850	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HC659_16860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC659_16870	COG0228	four-way junction DNA binding
HC659_16880	COG1837	Belongs to the UPF0109 family
HC659_16900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC659_16910	COG0336	Belongs to the RNA methyltransferase TrmD family
HC659_16920	COG0335	large ribosomal subunit rRNA binding
HC659_16930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC659_16940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC659_16960	COG2257	FlhB HrpN YscU SpaS Family
HC659_16970	COG0045	succinate-CoA ligase (ADP-forming) activity
HC659_16980	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC659_16990	COG0758	DNA mediated transformation
HC659_17000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC659_17010	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HC659_17020	COG4974	Belongs to the 'phage' integrase family
HC659_17030	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HC659_17040	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HC659_17050	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC659_17060	COG1815	bacterial-type flagellum-dependent cell motility
HC659_17070	COG1558	bacterial-type flagellum-dependent cell motility
HC659_17080	COG1677	Flagellar hook-basal body complex protein FliE
HC659_17090	COG1766	The M ring may be actively involved in energy transduction
HC659_17100	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC659_17110	COG1317	bacterial-type flagellum organization
HC659_17120	COG1157	protein secretion by the type III secretion system
HC659_17130	COG2882	bacterial-type flagellum organization
HC659_17140	COG3334	PFAM MgtE intracellular
HC659_17150	COG3144	bacterial-type flagellum assembly
HC659_17160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HC659_17170	COG4786	Flagellar basal body rod
HC659_17180	COG1582	Flagellar protein (FlbD)
HC659_17190	COG1580	Controls the rotational direction of flagella during chemotaxis
HC659_17200	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC659_17210	COG1776	CheC inhibitor of MCP methylation
HC659_17210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC659_17220	COG2201	protein-glutamate methylesterase activity
HC659_17230	COG3190	flagellar
HC659_17240	COG1338	Plays a role in the flagellum-specific transport system
HC659_17250	COG1987	bacterial-type flagellum assembly
HC659_17260	COG1684	flagellar biosynthetic protein fliR
HC659_17270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC659_17280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC659_17290	COG1419	protein localization to endoplasmic reticulum
HC659_17300	COG0455	bacterial-type flagellum organization
HC659_17310	COG2201	protein-glutamate methylesterase activity
HC659_17320	COG0643	Histidine kinase
HC659_17320	COG2198	Histidine kinase
HC659_17330	COG0835	chemotaxis
HC659_17340	COG1776	CheC inhibitor of MCP methylation
HC659_17350	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HC659_17360	COG1191	sigma factor activity
HC659_17380	COG0052	Belongs to the universal ribosomal protein uS2 family
HC659_17390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC659_17400	COG0528	UMP kinase activity
HC659_17410	COG0233	cytoplasmic translational termination
HC659_17420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC659_17430	COG4589	Belongs to the CDS family
HC659_17440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC659_17450	COG0750	zinc metalloprotease
HC659_17460	COG0442	prolyl-tRNA aminoacylation
HC659_17470	COG2176	DNA-directed DNA polymerase activity
HC659_17490	COG0779	Required for maturation of 30S ribosomal subunits
HC659_17500	COG0195	Participates in both transcription termination and antitermination
HC659_17510	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HC659_17520	COG1358	cellular component organization or biogenesis
HC659_17530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HC659_17540	COG1550	Protein conserved in bacteria
HC659_17550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC659_17560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC659_17570	COG0196	riboflavin kinase activity
HC659_17580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HC659_17590	COG1185	polyribonucleotide nucleotidyltransferase activity
HC659_17600	COG0726	polysaccharide deacetylase
HC659_17610	COG0612	Peptidase, M16
HC659_17620	COG1873	PFAM PRC-barrel domain
HC659_17630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC659_17640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC659_17650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC659_17660	COG0527	aspartate kinase activity
HC659_17670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC659_17680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC659_17690	COG0740	serine-type endopeptidase activity
HC659_17710	COG1674	ftsk spoiiie
HC659_17710	COG4980	gas vesicle protein
HC659_17720	COG2188	Transcriptional regulator
HC659_17730	COG2814	Major facilitator Superfamily
HC659_17740	COG0612	Peptidase, M16
HC659_17750	COG0612	Peptidase, M16
HC659_17760	COG0300	oxidoreductase activity
HC659_17790	COG1426	Protein conserved in bacteria
HC659_17800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC659_17810	COG1546	Belongs to the CinA family
HC659_17810	COG1058	Belongs to the CinA family
HC659_17820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HC659_17830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC659_17840	COG1418	mRNA catabolic process
HC659_17850	COG1692	metallophosphoesterase
HC659_17860	COG2359	stage V sporulation protein S
HC659_17870	COG1063	alcohol dehydrogenase
HC659_17880	COG0156	8-amino-7-oxononanoate synthase activity
HC659_17890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC659_17900	COG4550	Control of competence regulator ComK, YlbF/YmcA
HC659_17920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC659_17930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HC659_17960	COG3226	Transcriptional regulator
HC659_17970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC659_17980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC659_17990	COG3321	synthase
HC659_18000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC659_18000	COG2070	2-Nitropropane dioxygenase
HC659_18010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC659_18020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC659_18030	COG3425	synthase
HC659_18040	COG1024	Enoyl-CoA hydratase
HC659_18050	COG1024	Enoyl-CoA hydratase
HC659_18060	COG0318	PFAM AMP-dependent synthetase and ligase
HC659_18060	COG3321	synthase
HC659_18060	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_18060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_18060	COG0300	oxidoreductase activity
HC659_18070	COG4221	oxidoreductase activity
HC659_18070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC659_18070	COG0300	oxidoreductase activity
HC659_18070	COG3321	synthase
HC659_18080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC659_18080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC659_18080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_18080	COG3321	synthase
HC659_18080	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_18090	COG4221	oxidoreductase activity
HC659_18090	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_18090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_18090	COG3321	synthase
HC659_18100	COG3321	synthase
HC659_18100	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC659_18100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC659_18100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC659_18110	COG2124	cytochrome p450
HC659_18130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC659_18140	COG1404	Belongs to the peptidase S8 family
HC659_18160	COG4195	phage-related replication protein
HC659_18170	COG1764	response to oxidative stress
HC659_18180	COG2076	Multidrug Resistance protein
HC659_18190	COG2076	Multidrug Resistance protein
HC659_18220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC659_18230	COG1923	regulation of RNA biosynthetic process
HC659_18260	COG1780	Probably involved in ribonucleotide reductase function
HC659_18270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC659_18280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC659_18290	COG4112	unkown
HC659_18300	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC659_18320	COG0464	growth
HC659_18330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC659_18340	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HC659_18350	COG0789	Transcriptional regulator
HC659_18360	COG0174	glutamine synthetase
HC659_18400	COG4282	regulation of fungal-type cell wall biogenesis
HC659_18420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC659_18470	COG0135	phosphoribosylanthranilate isomerase activity
HC659_18480	COG2211	Major facilitator Superfamily
HC659_18490	COG3507	Belongs to the glycosyl hydrolase 43 family
HC659_18500	COG1940	carbohydrate kinase activity
HC659_18510	COG2115	Belongs to the xylose isomerase family
HC659_18520	COG1070	Carbohydrate kinase
HC659_18540	COG1525	nuclease
HC659_18550	COG2814	Major facilitator Superfamily
HC659_18560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC659_18580	COG0756	dUTP diphosphatase activity
HC659_18650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC659_18670	COG3832	glyoxalase III activity
HC659_18690	COG0697	spore germination
HC659_18700	COG0531	amino acid
HC659_18770	COG4195	phage-related replication protein
HC659_18790	COG0346	lactoylglutathione lyase activity
HC659_18820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC659_18830	COG1388	LysM domain
HC659_18840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC659_18850	COG4224	UPF0291 protein
HC659_18860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC659_18880	COG3763	UPF0154 protein
HC659_18900	COG0785	Cytochrome C biogenesis protein
HC659_18910	COG2201	protein-glutamate methylesterase activity
HC659_18920	COG4846	Membrane protein involved in cytochrome C biogenesis
HC659_18940	COG0071	Belongs to the small heat shock protein (HSP20) family
HC659_18970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC659_18980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_19020	COG0824	Thioesterase
HC659_19040	COG4841	protein insertion into membrane
HC659_19050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HC659_19060	COG1832	CoA-binding protein
HC659_19070	COG0187	DNA topoisomerase II activity
HC659_19080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC659_19110	COG1115	amino acid carrier protein
HC659_19120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HC659_19140	COG5520	Belongs to the glycosyl hydrolase 30 family
HC659_19150	COG3507	Belongs to the glycosyl hydrolase 43 family
HC659_19160	COG2246	polysaccharide biosynthetic process
HC659_19170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC659_19180	COG0586	Pfam SNARE associated Golgi protein
HC659_19190	COG2404	hydrolase activity, acting on ester bonds
HC659_19200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC659_19210	COG1024	Enoyl-CoA hydratase
HC659_19220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC659_19230	COG0511	ligase activity, forming carbon-carbon bonds
HC659_19240	COG0439	Biotin carboxylase
HC659_19250	COG0318	PFAM AMP-dependent synthetase and ligase
HC659_19260	COG1960	acyl-CoA dehydrogenase activity
HC659_19280	COG1649	PFAM Uncharacterised BCR, COG1649
HC659_19300	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC659_19300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_19310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_19320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_19330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_19340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_19350	COG2027	D-alanyl-D-alanine carboxypeptidase
HC659_19360	COG2017	converts alpha-aldose to the beta-anomer
HC659_19370	COG0534	Mate efflux family protein
HC659_19400	COG0582	viral genome integration into host DNA
HC659_19410	COG0166	Belongs to the GPI family
HC659_19420	COG0405	Gamma-glutamyltransferase
HC659_19430	COG0583	DNA-binding transcription factor activity
HC659_19440	COG0604	alcohol dehydrogenase
HC659_19450	COG0493	'glutamate synthase
HC659_19460	COG0067	glutamate synthase
HC659_19460	COG0069	glutamate synthase activity
HC659_19460	COG0070	glutamate synthase
HC659_19470	COG0583	DNA-binding transcription factor activity
HC659_19480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC659_19490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC659_19510	COG0300	oxidoreductase activity
HC659_19520	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC659_19540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC659_19550	COG2814	Major facilitator Superfamily
HC659_19560	COG1070	Carbohydrate kinase
HC659_19570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC659_19580	COG0243	molybdopterin cofactor binding
HC659_19630	COG0840	transmembrane signaling receptor activity
HC659_19630	COG5278	phosphoserine phosphatase activity
HC659_19640	COG2368	4-hydroxyphenylacetate
HC659_19650	COG4305	rare lipoprotein A
HC659_19660	COG3619	membrane
HC659_19670	COG3866	Pectate lyase
HC659_19680	COG2135	peptidase activity
HC659_19700	COG2140	Oxalate decarboxylase
HC659_19720	COG0456	acetyltransferase
HC659_19740	COG2720	vancomycin resistance protein
HC659_19760	COG3655	Transcriptional regulator
HC659_19770	COG3739	integral membrane protein
HC659_19780	COG0583	DNA-binding transcription factor activity
HC659_19790	COG0697	spore germination
HC659_19810	COG0693	protein deglycase activity
HC659_19820	COG2367	Beta-lactamase
HC659_19850	COG0574	Belongs to the PEP-utilizing enzyme family
HC659_19850	COG3848	Pyruvate phosphate dikinase
HC659_19870	COG0726	polysaccharide deacetylase
HC659_19880	COG2314	TM2 domain
HC659_19890	COG1396	sequence-specific DNA binding
HC659_19920	COG2135	peptidase activity
HC659_19970	COG0457	Tetratricopeptide repeat
HC659_19990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC659_20000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC659_20030	COG5290	Psort location Cytoplasmic, score
HC659_20080	COG5444	nuclease activity
HC659_20090	COG4282	regulation of fungal-type cell wall biogenesis
HC659_20100	COG1231	oxidoreductase activity
HC659_20110	COG5434	Belongs to the glycosyl hydrolase 28 family
HC659_20130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC659_20140	COG2207	Transcriptional regulator
HC659_20140	COG0662	Cupin 2, conserved barrel domain protein
HC659_20150	COG0456	acetyltransferase
HC659_20160	COG1309	transcriptional regulator
HC659_20170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC659_20180	COG3708	Transcriptional regulator
HC659_20190	COG2378	regulation of single-species biofilm formation
HC659_20210	COG0640	Transcriptional regulator
HC659_20220	COG0741	lytic transglycosylase activity
HC659_20230	COG2322	membrane
HC659_20260	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC659_20270	COG3239	Fatty acid desaturase
HC659_20280	COG4585	Histidine kinase
HC659_20290	COG2197	response regulator
HC659_20300	COG1388	LysM domain
HC659_20300	COG3584	3D domain protein
HC659_20310	COG0514	ATP-dependent DNA helicase (RecQ)
HC659_20340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC659_20350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC659_20380	COG0071	Belongs to the small heat shock protein (HSP20) family
HC659_20430	COG1012	belongs to the aldehyde dehydrogenase family
HC659_20440	COG1657	PFAM Prenyltransferase squalene oxidase
HC659_20450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC659_20460	COG0733	neurotransmitter:sodium symporter activity
HC659_20470	COG0385	Bile acid
HC659_20480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC659_20490	COG0567	Dehydrogenase, E1 component
HC659_20500	COG4548	von Willebrand factor, type A
HC659_20510	COG0714	Associated with various cellular activities
HC659_20520	COG2032	superoxide dismutase activity
HC659_20530	COG1388	LysM domain
HC659_20530	COG0791	NLP P60 protein
HC659_20540	COG1819	glycosyl
HC659_20550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC659_20560	COG0534	Mate efflux family protein
HC659_20570	COG1366	Belongs to the anti-sigma-factor antagonist family
HC659_20580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC659_20590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC659_20610	COG2962	Rard protein
HC659_20640	COG2610	gluconate transmembrane transporter activity
HC659_20650	COG1942	4-Oxalocrotonate Tautomerase
HC659_20670	COG1733	regulation of RNA biosynthetic process
HC659_20680	COG0778	Nitroreductase
HC659_20690	COG0400	carboxylic ester hydrolase activity
HC659_20700	COG0346	lactoylglutathione lyase activity
HC659_20720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC659_20730	COG3409	Peptidoglycan-binding domain 1 protein
HC659_20730	COG0793	Belongs to the peptidase S41A family
HC659_20740	COG2226	methyltransferase
HC659_20760	COG1876	peptidase activity
HC659_20770	COG0813	purine-nucleoside phosphorylase activity
HC659_20800	COG0671	phosphoesterase, PA-phosphatase related
HC659_20840	COG4479	Belongs to the UPF0346 family
HC659_20860	COG1509	lysine 2,3-aminomutase activity
HC659_20870	COG0456	acetyltransferase
HC659_20880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC659_20890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC659_20900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC659_20910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC659_20930	COG0456	acetyltransferase
HC659_20940	COG0463	Glycosyl transferase, family 2
HC659_20970	COG4641	Protein conserved in bacteria
HC659_20980	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HC659_20990	COG1086	Polysaccharide biosynthesis protein
HC659_21000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC659_21010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC659_21020	COG1846	Transcriptional regulator
HC659_21030	COG0534	Mate efflux family protein
HC659_21050	COG4698	Protein conserved in bacteria
HC659_21060	COG2755	lipolytic protein G-D-S-L family
HC659_21070	COG1999	signal sequence binding
HC659_21090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC659_21100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC659_21110	COG1272	protein, Hemolysin III
HC659_21120	COG0204	Acyl-transferase
HC659_21130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC659_21140	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HC659_21150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC659_21170	COG2136	Putative SAM-dependent methyltransferase
HC659_21170	COG2521	methyltransferase
HC659_21190	COG0129	dihydroxy-acid dehydratase activity
HC659_21200	COG1413	lyase activity
HC659_21210	COG1418	mRNA catabolic process
HC659_21220	COG0386	Belongs to the glutathione peroxidase family
HC659_21230	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HC659_21240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC659_21250	COG1278	Cold shock
HC659_21290	COG0328	RNA-DNA hybrid ribonuclease activity
HC659_21300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HC659_21310	COG0328	RNA-DNA hybrid ribonuclease activity
HC659_21330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC659_21360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC659_21370	COG1755	Isoprenylcysteine carboxyl methyltransferase
HC659_21380	COG3424	synthase
HC659_21390	COG2233	PERMEase
HC659_21400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC659_21410	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC659_21430	COG0800	Aldolase
HC659_21440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC659_21450	COG1609	Transcriptional regulator
HC659_21460	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HC659_21470	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_21480	COG1199	ATP-dependent helicase activity
HC659_21500	COG0116	Belongs to the methyltransferase superfamily
HC659_21520	COG4474	Belongs to the UPF0398 family
HC659_21530	COG3359	exonuclease
HC659_21540	COG1111	helicase
HC659_21540	COG1205	dead DEAH box helicase
HC659_21550	COG2190	(PTS) system
HC659_21560	COG0071	Belongs to the small heat shock protein (HSP20) family
HC659_21630	COG3331	DNA recombination
HC659_21640	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC659_21640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC659_21660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC659_21670	COG3935	DnaD domain protein
HC659_21680	COG0017	Asparaginyl-tRNA synthetase
HC659_21690	COG0436	Aminotransferase
HC659_21700	COG5353	protein conserved in bacteria
HC659_21720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC659_21720	COG1199	ATP-dependent helicase activity
HC659_21730	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HC659_21740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HC659_21750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HC659_21760	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HC659_21760	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HC659_21770	COG0617	tRNA 3'-terminal CCA addition
HC659_21780	COG0438	transferase activity, transferring glycosyl groups
HC659_21790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC659_21800	COG1803	Methylglyoxal synthase
HC659_21810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HC659_21820	COG1694	Mazg nucleotide pyrophosphohydrolase
HC659_21830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC659_21850	COG4347	Protein of unknown function (DUF1405)
HC659_21860	COG2010	Cytochrome c
HC659_21860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC659_21870	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC659_21880	COG0723	plastoquinol--plastocyanin reductase activity
HC659_21900	COG5582	Belongs to the UPF0302 family
HC659_21910	COG0457	Tetratricopeptide repeat
HC659_21920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC659_21930	COG0287	Prephenate dehydrogenase
HC659_21940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC659_21950	COG0159	tryptophan synthase activity
HC659_21960	COG0133	tryptophan synthase activity
HC659_21970	COG0135	phosphoribosylanthranilate isomerase activity
HC659_21990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC659_22000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC659_22010	COG4401	Chorismate mutase type I
HC659_22020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HC659_22030	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC659_22040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HC659_22050	COG0105	UTP biosynthetic process
HC659_22060	COG0142	geranyltranstransferase activity
HC659_22070	COG2226	methyltransferase
HC659_22080	COG0142	geranyltranstransferase activity
HC659_22100	COG0302	gtp cyclohydrolase
HC659_22110	COG0776	regulation of translation
HC659_22120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC659_22150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC659_22160	COG1160	GTP binding
HC659_22210	COG1304	FMN binding
HC659_22220	COG0539	negative regulation of cytoplasmic translation
HC659_22230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC659_22250	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HC659_22260	COG2959	enzyme of heme biosynthesis
HC659_22270	COG3409	Peptidoglycan-binding domain 1 protein
HC659_22270	COG3773	Cell wall hydrolase
HC659_22280	COG2339	peptidase activity
HC659_22290	COG0492	ferredoxin-NADP+ reductase activity
HC659_22300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC659_22310	COG4862	establishment of competence for transformation
HC659_22320	COG1408	metallophosphoesterase
HC659_22340	COG1388	LysM domain
HC659_22350	COG1266	CAAX protease self-immunity
HC659_22360	COG0514	ATP-dependent DNA helicase (RecQ)
HC659_22370	COG4955	Helix-turn-helix domain
HC659_22380	COG1141	Ferredoxin
HC659_22390	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HC659_22400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC659_22410	COG0710	3-dehydroquinate dehydratase activity
HC659_22430	COG1595	DNA-templated transcription, initiation
HC659_22440	COG5002	protein histidine kinase activity
HC659_22450	COG0745	RESPONSE REGULATOR receiver
HC659_22460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC659_22470	COG1333	cytochrome c biogenesis protein
HC659_22480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_22490	COG1187	pseudouridine synthase activity
HC659_22500	COG0700	Nucleoside recognition
HC659_22510	COG2715	membrane protein required for spore maturation
HC659_22520	COG1686	Belongs to the peptidase S11 family
HC659_22540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HC659_22550	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HC659_22560	COG1547	Domain of unknown function (DUF309)
HC659_22570	COG0456	acetyltransferase
HC659_22580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HC659_22590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC659_22590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC659_22600	COG0307	riboflavin synthase, alpha
HC659_22610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC659_22610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC659_22630	COG0681	Belongs to the peptidase S26 family
HC659_22640	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HC659_22680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC659_22690	COG4086	secreted protein
HC659_22700	COG0019	diaminopimelate decarboxylase activity
HC659_22710	COG0697	spore germination
HC659_22740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC659_22780	COG1191	sigma factor activity
HC659_22790	COG2172	sigma factor antagonist activity
HC659_22800	COG1366	Belongs to the anti-sigma-factor antagonist family
HC659_22810	COG1686	Belongs to the peptidase S11 family
HC659_22820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HC659_22830	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HC659_22840	COG4974	Belongs to the 'phage' integrase family
HC659_22860	COG0735	belongs to the Fur family
HC659_22870	COG1300	Membrane
HC659_22890	COG0281	malic enzyme
HC659_22900	COG1757	Na H antiporter
HC659_22910	COG1027	Aspartate ammonia-lyase
HC659_22920	COG0252	asparaginase activity
HC659_22930	COG1396	sequence-specific DNA binding
HC659_22940	COG1379	DNA repair
HC659_22950	COG0494	nUDIX hydrolase
HC659_22970	COG0667	Aldo Keto reductase
HC659_22990	COG1073	alpha beta
HC659_23010	COG4918	Iron-sulphur cluster biosynthesis
HC659_23020	COG0456	acetyltransferase
HC659_23020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC659_23030	COG2329	Antibiotic biosynthesis monooxygenase
HC659_23040	COG0456	acetyltransferase
HC659_23060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC659_23080	COG2211	Major facilitator Superfamily
HC659_23100	COG0346	lactoylglutathione lyase activity
HC659_23110	COG1072	(Pantothenic acid kinase))
HC659_23120	COG3048	D-serine ammonia-lyase activity
HC659_23130	COG0300	oxidoreductase activity
HC659_23140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC659_23150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC659_23160	COG4187	Peptidase family M20/M25/M40
HC659_23170	COG1902	pentaerythritol trinitrate reductase activity
HC659_23180	COG0596	Alpha beta hydrolase
HC659_23190	COG1234	tRNA 3'-trailer cleavage
HC659_23200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HC659_23210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC659_23220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC659_23240	COG0706	membrane insertase activity
HC659_23250	COG3361	conserved protein (COG2071)
HC659_23260	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC659_23270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC659_23280	COG0346	lactoylglutathione lyase activity
HC659_23290	COG1376	ErfK ybiS ycfS ynhG family protein
HC659_23300	COG4129	membrane
HC659_23310	COG1126	abc transporter atp-binding protein
HC659_23320	COG0765	amino acid transport
HC659_23330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC659_23350	COG1597	lipid kinase activity
HC659_23360	COG2814	Major facilitator Superfamily
HC659_23370	COG4978	Transcriptional regulator
HC659_23370	COG0789	Transcriptional regulator
HC659_23380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC659_23390	COG0022	dehydrogenase e1 component
HC659_23400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC659_23410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC659_23420	COG3426	butyrate kinase activity
HC659_23430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC659_23440	COG0280	phosphate acetyltransferase
HC659_23450	COG3829	transcription factor binding
HC659_23450	COG3290	protein histidine kinase activity
HC659_23470	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HC659_23480	COG2079	MmgE PrpD family protein
HC659_23490	COG0372	Belongs to the citrate synthase family
HC659_23500	COG1960	acyl-CoA dehydrogenase activity
HC659_23510	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC659_23520	COG0183	Belongs to the thiolase family
HC659_23530	COG0584	glycerophosphoryl diester phosphodiesterase
HC659_23540	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC659_23560	COG1902	pentaerythritol trinitrate reductase activity
HC659_23570	COG0745	RESPONSE REGULATOR receiver
HC659_23590	COG0750	zinc metalloprotease
HC659_23600	COG0497	DNA recombination
HC659_23610	COG1438	arginine binding
HC659_23620	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HC659_23630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HC659_23640	COG0142	geranyltranstransferase activity
HC659_23650	COG1722	exodeoxyribonuclease VII activity
HC659_23660	COG1570	exodeoxyribonuclease VII activity
HC659_23670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HC659_23680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC659_23690	COG1302	Protein conserved in bacteria
HC659_23700	COG0439	Biotin carboxylase
HC659_23710	COG0511	ligase activity, forming carbon-carbon bonds
HC659_23790	COG3854	ATPases associated with a variety of cellular activities
HC659_23810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC659_23820	COG0006	proline dipeptidase activity
HC659_23830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HC659_23850	COG3872	metal-dependent enzyme
HC659_23870	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC659_23880	COG1321	iron dependent repressor
HC659_23890	COG0095	Lipoate-protein ligase
HC659_23900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC659_23910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC659_23920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC659_23930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC659_23940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC659_23970	COG1396	sequence-specific DNA binding
HC659_23990	COG0681	Belongs to the peptidase S26 family
HC659_24040	COG4940	Competence protein ComGF
HC659_24060	COG4970	Tfp pilus assembly protein FimT
HC659_24070	COG4537	Required for transformation and DNA binding
HC659_24080	COG1459	type II secretion system
HC659_24090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC659_24110	COG0517	IMP dehydrogenase activity
HC659_24120	COG0598	Magnesium transport protein CorA
HC659_24130	COG1253	flavin adenine dinucleotide binding
HC659_24140	COG1366	Belongs to the anti-sigma-factor antagonist family
HC659_24160	COG1393	Belongs to the ArsC family
HC659_24180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC659_24200	COG0011	TIGRFAM Protein of
HC659_24220	COG2866	Carboxypeptidase
HC659_24230	COG1368	sulfuric ester hydrolase activity
HC659_24240	COG1940	carbohydrate kinase activity
HC659_24250	COG4483	Protein conserved in bacteria
HC659_24260	COG0457	Tetratricopeptide repeat
HC659_24260	COG0705	Rhomboid family
HC659_24280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC659_24300	COG0438	transferase activity, transferring glycosyl groups
HC659_24330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC659_24340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC659_24350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC659_24360	COG0581	inorganic phosphate transmembrane transporter activity
HC659_24370	COG0573	inorganic phosphate transmembrane transporter activity
HC659_24380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC659_24400	COG0477	Major facilitator Superfamily
HC659_24410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC659_24420	COG2839	Protein conserved in bacteria
HC659_24430	COG5521	maltodextrose utilization protein MalA
HC659_24450	COG1388	LysM domain
HC659_24460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HC659_24470	COG4709	membrane
HC659_24480	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HC659_24490	COG0735	belongs to the Fur family
HC659_24500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC659_24520	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HC659_24530	COG0513	Belongs to the DEAD box helicase family
HC659_24550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HC659_24560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC659_24570	COG2384	SAM-dependent methyltransferase
HC659_24580	COG2010	Cytochrome c
HC659_24600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC659_24610	COG0358	DNA primase activity
HC659_24620	COG1671	Belongs to the UPF0178 family
HC659_24630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HC659_24640	COG0517	IMP dehydrogenase activity
HC659_24650	COG0751	glycine-tRNA ligase activity
HC659_24660	COG0752	glycyl-tRNA synthetase alpha subunit
HC659_24670	COG1381	Involved in DNA repair and RecF pathway recombination
HC659_24690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC659_24700	COG0295	cytidine deaminase activity
HC659_24710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC659_24720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC659_24730	COG1480	7TM receptor with intracellular HD hydrolase
HC659_24740	COG1702	phosphate starvation-inducible protein PhoH
HC659_24750	COG0561	phosphatase activity
HC659_24780	COG4864	UPF0365 protein
HC659_24790	COG1030	water channel activity
HC659_24800	COG1610	YqeY-like protein
HC659_24820	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC659_24830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC659_24840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC659_24850	COG2264	protein methyltransferase activity
HC659_24860	COG0484	heat shock protein binding
HC659_24880	COG0443	Heat shock 70 kDa protein
HC659_24890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC659_24900	COG1420	regulation of RNA biosynthetic process
HC659_24910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC659_24920	COG0481	GTPase activity
HC659_24940	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC659_24950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HC659_24960	COG0268	Binds directly to 16S ribosomal RNA
HC659_24970	COG1466	dna polymerase III delta subunit
HC659_24980	COG2333	competence protein COMEC
HC659_24980	COG0658	competence protein
HC659_24990	COG2131	deaminase
HC659_25000	COG1555	photosystem II stabilization
HC659_25000	COG1596	polysaccharide export
HC659_25010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC659_25020	COG2226	methyltransferase
HC659_25030	COG0799	negative regulation of ribosome biogenesis
HC659_25040	COG1713	HD superfamily hydrolase involved in NAD metabolism
HC659_25050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC659_25060	COG1534	Rna-binding protein
HC659_25070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC659_25080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC659_25090	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HC659_25110	COG2755	lipolytic protein G-D-S-L family
HC659_25120	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC659_25120	COG3409	Peptidoglycan-binding domain 1 protein
HC659_25130	COG0398	Pfam SNARE associated Golgi protein
HC659_25140	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HC659_25160	COG3209	COG3209 Rhs family protein
HC659_25170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC659_25180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC659_25190	COG0798	PFAM Bile acid sodium symporter
HC659_25200	COG0346	lactoylglutathione lyase activity
HC659_25210	COG0640	Transcriptional regulator
HC659_25220	COG3403	YqcI/YcgG family
HC659_25230	COG0457	Tetratricopeptide repeat
HC659_25260	COG5444	nuclease activity
HC659_25300	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC659_25300	COG3409	Peptidoglycan-binding domain 1 protein
HC659_25310	COG4824	toxin secretion phage lysis holin
HC659_25370	COG3778	Protein conserved in bacteria
HC659_25380	COG3299	homolog of phage Mu protein gp47
HC659_25390	COG3628	GPW Gp25 family protein
HC659_25410	COG4193	domain, Protein
HC659_25420	COG1652	LysM domain
HC659_25430	COG3953	SLT domain
HC659_25430	COG5280	Phage tail tape measure protein TP901
HC659_25570	COG4653	Phage capsid family
HC659_25580	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC659_25600	COG2369	cell adhesion
HC659_25610	COG5518	Phage portal protein
HC659_25620	COG1783	phage Terminase large subunit
HC659_25630	COG5484	DNA packaging
HC659_25650	COG3677	Transposase
HC659_25680	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HC659_25700	COG1484	DNA-dependent DNA replication
HC659_25710	COG3935	DnaD domain protein
HC659_25720	COG3723	Recombinational DNA repair protein, rece pathway
HC659_25730	COG5377	YqaJ viral recombinase family
HC659_25780	COG1476	TRANSCRIPTIONal
HC659_25790	COG3620	sequence-specific DNA binding
HC659_25800	COG0563	adenylate kinase activity
HC659_25810	COG2856	Zn peptidase
HC659_25830	COG3223	Belongs to the PsiE family
HC659_25840	COG5002	protein histidine kinase activity
HC659_25840	COG0642	Histidine kinase
HC659_25850	COG0745	RESPONSE REGULATOR receiver
HC659_25860	COG2311	Membrane
HC659_25870	COG0454	-acetyltransferase
HC659_25880	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC659_25900	COG0730	response to heat
HC659_25910	COG0425	Belongs to the sulfur carrier protein TusA family
HC659_25920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC659_25920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC659_25940	COG0425	Belongs to the sulfur carrier protein TusA family
HC659_25940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC659_25950	COG2210	Belongs to the sulfur carrier protein TusA family
HC659_25960	COG1937	Protein conserved in bacteria
HC659_25970	COG0662	Cupin 2, conserved barrel domain protein
HC659_25980	COG0789	Transcriptional regulator
HC659_25980	COG4978	Transcriptional regulator
HC659_25990	COG2814	Major facilitator Superfamily
HC659_26000	COG0456	acetyltransferase
HC659_26010	COG1253	flavin adenine dinucleotide binding
HC659_26030	COG0697	spore germination
HC659_26040	COG0583	DNA-binding transcription factor activity
HC659_26050	COG2072	flavoprotein involved in K transport
HC659_26060	COG1230	cation diffusion facilitator family transporter
HC659_26070	COG1942	4-Oxalocrotonate Tautomerase
HC659_26080	COG0583	DNA-binding transcription factor activity
HC659_26100	COG1114	Component of the transport system for branched-chain amino acids
HC659_26110	COG1687	branched-chain amino acid
HC659_26120	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HC659_26130	COG1522	sequence-specific DNA binding
HC659_26140	COG2732	(Barnase) inhibitor
HC659_26150	COG2124	cytochrome p450
HC659_26170	COG1335	isochorismatase
HC659_26190	COG2318	DinB family
HC659_26210	COG2070	2-Nitropropane dioxygenase
HC659_26220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC659_26250	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC659_26260	COG1595	DNA-templated transcription, initiation
HC659_26270	COG0667	Aldo Keto reductase
HC659_26280	COG2851	Citrate transporter
HC659_26290	COG0583	DNA-binding transcription factor activity
HC659_26300	COG2828	Protein conserved in bacteria
HC659_26310	COG3409	Peptidoglycan-binding domain 1 protein
HC659_26320	COG5566	PFAM Mor transcription activator
HC659_26330	COG0596	Alpha beta hydrolase
HC659_26340	COG4991	sh3 domain protein
HC659_26350	COG4991	sh3 domain protein
HC659_26360	COG0346	lactoylglutathione lyase activity
HC659_26380	COG5577	PFAM Coat F domain
HC659_26390	COG1063	alcohol dehydrogenase
HC659_26410	COG5577	PFAM Coat F domain
HC659_26420	COG0789	Transcriptional regulator
HC659_26440	COG1064	alcohol dehydrogenase
HC659_26450	COG0693	protein deglycase activity
HC659_26460	COG1621	beta-fructofuranosidase activity
HC659_26470	COG3716	PTS system mannose fructose sorbose family IID component
HC659_26480	COG3715	PTS system
HC659_26490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_26500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC659_26510	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC659_26510	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC659_26520	COG1113	amino acid transport
HC659_26530	COG1280	lysine exporter protein (LysE YggA)
HC659_26540	COG1378	Sugar-specific transcriptional regulator TrmB
HC659_26550	COG1595	DNA-templated transcription, initiation
HC659_26570	COG2755	lipolytic protein G-D-S-L family
HC659_26570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HC659_26590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC659_26590	COG2124	cytochrome p450
HC659_26600	COG1309	transcriptional regulator
HC659_26610	COG2226	methyltransferase
HC659_26640	COG2116	formate transmembrane transporter activity
HC659_26650	COG5609	conserved protein (DUF2294)
HC659_26660	COG3383	formate dehydrogenase (NAD+) activity
HC659_26670	COG2427	Protein of unknown function (DUF1641)
HC659_26690	COG0626	cystathionine gamma-synthase activity
HC659_26700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC659_26710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC659_26720	COG2226	methyltransferase
HC659_26750	COG0768	penicillin binding
HC659_26760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC659_26770	COG0572	uridine kinase
HC659_26800	COG4122	O-methyltransferase activity
HC659_26810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC659_26820	COG3906	Belongs to the UPF0473 family
HC659_26830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC659_26840	COG4472	Bacterial protein of unknown function (DUF965)
HC659_26850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC659_26860	COG0628	permease
HC659_26870	COG1126	abc transporter atp-binding protein
HC659_26880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC659_26890	COG0765	amino acid transport
HC659_26900	COG0765	amino acid transport
HC659_26930	COG3881	PFAM PRC-barrel domain
HC659_26940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC659_26950	COG0457	Tetratricopeptide repeat
HC659_26960	COG0482	sulfurtransferase activity
HC659_26970	COG1104	cysteine desulfurase activity
HC659_26980	COG1959	2 iron, 2 sulfur cluster binding
HC659_26990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC659_27000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HC659_27030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC659_27040	COG0124	histidyl-tRNA synthetase
HC659_27060	COG4991	sh3 domain protein
HC659_27060	COG3103	Sh3 type 3 domain protein
HC659_27060	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC659_27070	COG1490	D-aminoacyl-tRNA deacylase activity
HC659_27080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC659_27090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC659_27100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HC659_27100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC659_27110	COG5416	Lipopolysaccharide assembly protein A domain
HC659_27120	COG0490	domain, Protein
HC659_27130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC659_27130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC659_27150	COG2244	polysaccharide biosynthetic process
HC659_27160	COG2323	membrane
HC659_27180	COG1862	Preprotein translocase
HC659_27190	COG0343	queuine tRNA-ribosyltransferase activity
HC659_27200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HC659_27220	COG2255	four-way junction helicase activity
HC659_27230	COG0632	four-way junction helicase activity
HC659_27250	COG2814	Major facilitator Superfamily
HC659_27260	COG0673	inositol 2-dehydrogenase activity
HC659_27270	COG2112	serine threonine protein kinase
HC659_27300	COG1115	amino acid carrier protein
HC659_27310	COG0217	transcriptional regulatory protein
HC659_27330	COG1388	LysM domain
HC659_27340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC659_27350	COG0157	Belongs to the NadC ModD family
HC659_27360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC659_27370	COG1104	cysteine desulfurase activity
HC659_27380	COG1827	regulation of RNA biosynthetic process
HC659_27390	COG0077	Prephenate dehydratase
HC659_27400	COG4492	Belongs to the UPF0735 family
HC659_27410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC659_27420	COG3290	protein histidine kinase activity
HC659_27430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC659_27440	COG2868	ribosomal protein
HC659_27450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC659_27460	COG1994	Peptidase M50
HC659_27470	COG0739	heme binding
HC659_27480	COG2894	cell division
HC659_27490	COG0850	regulation of cytokinetic process
HC659_27500	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC659_27520	COG1077	Cell shape determining protein MreB Mrl
HC659_27530	COG2003	Belongs to the UPF0758 family
HC659_27540	COG0424	maF-like protein
HC659_27560	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HC659_27570	COG0285	dihydrofolate synthase activity
HC659_27580	COG0525	valine-tRNA ligase activity
HC659_27600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC659_27610	COG1388	LysM domain
HC659_27620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC659_27630	COG0113	porphobilinogen synthase activity
HC659_27640	COG1587	Uroporphyrinogen-III synthase
HC659_27650	COG0181	hydroxymethylbilane synthase activity
HC659_27660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC659_27670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HC659_27690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HC659_27700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC659_27710	COG1067	ATP-dependent peptidase activity
HC659_27710	COG0470	DNA polymerase III
HC659_27720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC659_27730	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC659_27740	COG1477	protein flavinylation
HC659_27740	COG0457	Tetratricopeptide repeat
HC659_27750	COG0066	3-isopropylmalate dehydratase activity
HC659_27760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HC659_27770	COG0473	3-isopropylmalate dehydrogenase activity
HC659_27780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC659_27790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HC659_27800	COG0440	acetolactate synthase activity
HC659_27810	COG0028	Belongs to the TPP enzyme family
HC659_27830	COG0454	-acetyltransferase
HC659_27850	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HC659_27870	COG0622	Phosphoesterase
HC659_27880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC659_27890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC659_27900	COG5401	PFAM Sporulation and spore germination
HC659_27910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC659_27920	COG1846	Transcriptional regulator
HC659_27930	COG2197	response regulator
HC659_27940	COG0824	Thioesterase
HC659_27950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC659_27960	COG1053	succinate dehydrogenase
HC659_27970	COG2009	succinate dehydrogenase
HC659_27980	COG1719	4-vinyl reductase, 4VR
HC659_27990	COG0527	aspartate kinase activity
HC659_28000	COG0322	excinuclease ABC activity
HC659_28010	COG3118	belongs to the thioredoxin family
HC659_28030	COG3534	alpha-L-arabinofuranosidase
HC659_28040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HC659_28050	COG2086	electron transfer activity
HC659_28060	COG1024	Enoyl-CoA hydratase
HC659_28070	COG1309	transcriptional regulator
HC659_28080	COG0318	PFAM AMP-dependent synthetase and ligase
HC659_28090	COG3766	membrane
HC659_28100	COG1193	negative regulation of DNA recombination
HC659_28110	COG1796	DNA polymerase
HC659_28110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC659_28120	COG1286	toxin biosynthetic process
HC659_28130	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HC659_28140	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC659_28150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC659_28150	COG0072	phenylalanine-tRNA ligase activity
HC659_28160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC659_28170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC659_28190	COG3835	regulator
HC659_28200	COG0277	FAD linked oxidase domain protein
HC659_28210	COG0247	lactate metabolic process
HC659_28220	COG0346	lactoylglutathione lyase activity
HC659_28230	COG1966	Carbon starvation protein
HC659_28240	COG3534	alpha-L-arabinofuranosidase
HC659_28250	COG0395	ABC-type sugar transport system, permease component
HC659_28260	COG1175	transmembrane transport
HC659_28270	COG1653	transport
HC659_28280	COG0371	Dehydrogenase
HC659_28290	COG0647	UMP catabolic process
HC659_28300	COG0235	Class ii aldolase
HC659_28310	COG1069	ribulokinase activity
HC659_28320	COG2160	L-arabinose isomerase activity
HC659_28330	COG3507	Belongs to the glycosyl hydrolase 43 family
HC659_28340	COG1363	Peptidase, m42
HC659_28360	COG3326	Membrane
HC659_28370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC659_28380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC659_28390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC659_28410	COG1346	cytolysis
HC659_28420	COG1380	Effector of murein hydrolase LrgA
HC659_28430	COG3279	Response regulator of the LytR AlgR family
HC659_28440	COG3275	phosphorelay sensor kinase activity
HC659_28450	COG1011	Hydrolase
HC659_28460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC659_28480	COG0398	Pfam SNARE associated Golgi protein
HC659_28490	COG1484	DNA-dependent DNA replication
HC659_28500	COG3611	Membrane attachment protein
HC659_28510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC659_28520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HC659_28530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC659_28540	COG1733	regulation of RNA biosynthetic process
HC659_28550	COG2814	Major facilitator Superfamily
HC659_28560	COG0656	L-ascorbic acid biosynthetic process
HC659_28570	COG0237	dephospho-CoA kinase activity
HC659_28580	COG1971	Probably functions as a manganese efflux pump
HC659_28590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC659_28600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC659_28600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC659_28610	COG5002	protein histidine kinase activity
HC659_28620	COG0745	RESPONSE REGULATOR receiver
HC659_28630	COG0039	L-malate dehydrogenase activity
HC659_28640	COG0538	isocitrate dehydrogenase activity
HC659_28650	COG0372	Belongs to the citrate synthase family
HC659_28660	COG2707	UPF0756 membrane protein
HC659_28670	COG0628	permease
HC659_28680	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC659_28690	COG0469	pyruvate kinase activity
HC659_28700	COG0205	6-phosphofructokinase activity
HC659_28710	COG0825	malonyl-CoA metabolic process
HC659_28720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC659_28730	COG0281	malic enzyme
HC659_28740	COG0587	DNA-directed DNA polymerase activity
HC659_28780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HC659_28800	COG4109	DRTGG domain
HC659_28810	COG0730	response to heat
HC659_28820	COG1473	amidohydrolase
HC659_28830	COG0196	riboflavin kinase activity
HC659_28840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC659_28850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HC659_28860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC659_28870	COG1126	abc transporter atp-binding protein
HC659_28880	COG0765	amino acid transport
HC659_28890	COG0765	amino acid transport
HC659_28900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC659_28910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC659_28920	COG0454	-acetyltransferase
HC659_28930	COG0583	DNA-binding transcription factor activity
HC659_28940	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC659_28950	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_28970	COG0165	Argininosuccinate lyase
HC659_28980	COG0137	argininosuccinate synthase activity
HC659_28990	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC659_29000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HC659_29010	COG0827	DNA restriction-modification system
HC659_29020	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HC659_29030	COG3874	Sporulation protein YtfJ
HC659_29050	COG1714	RDD family
HC659_29060	COG0616	signal peptide processing
HC659_29070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC659_29080	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HC659_29090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC659_29110	COG0301	tRNA thio-modification
HC659_29120	COG1104	cysteine desulfurase activity
HC659_29130	COG1114	Component of the transport system for branched-chain amino acids
HC659_29140	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HC659_29150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC659_29160	COG1309	transcriptional regulator
HC659_29170	COG1956	GAF domain-containing protein
HC659_29180	COG2199	diguanylate cyclase activity
HC659_29180	COG2203	Gaf domain
HC659_29200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC659_29210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC659_29220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC659_29230	COG0454	-acetyltransferase
HC659_29240	COG0517	IMP dehydrogenase activity
HC659_29250	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC659_29260	COG1360	Flagellar Motor Protein
HC659_29270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC659_29280	COG1609	Transcriptional regulator
HC659_29290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HC659_29290	COG1605	Chorismate mutase
HC659_29300	COG3118	belongs to the thioredoxin family
HC659_29310	COG4980	gas vesicle protein
HC659_29320	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC659_29330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC659_29340	COG1674	ftsk spoiiie
HC659_29350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC659_29360	COG4848	Belongs to the UPF0354 family
HC659_29370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_29390	COG1363	Peptidase, m42
HC659_29400	COG5584	Small secreted protein
HC659_29410	COG0281	malic enzyme
HC659_29420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC659_29430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC659_29450	COG0510	thiamine kinase activity
HC659_29460	COG1523	belongs to the glycosyl hydrolase 13 family
HC659_29470	COG1597	lipid kinase activity
HC659_29490	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC659_29500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC659_29510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC659_29520	COG2252	PERMEase
HC659_29530	COG4473	ABC transporter
HC659_29540	COG1131	(ABC) transporter
HC659_29550	COG1349	DNA-binding transcription factor activity
HC659_29560	COG1187	pseudouridine synthase activity
HC659_29570	COG2244	polysaccharide biosynthetic process
HC659_29580	COG2081	HI0933 family
HC659_29590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC659_29610	COG5578	integral membrane protein
HC659_29620	COG0673	inositol 2-dehydrogenase activity
HC659_29630	COG1653	transport
HC659_29640	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC659_29650	COG4209	transmembrane transport
HC659_29660	COG2207	Transcriptional regulator
HC659_29670	COG1653	transport
HC659_29680	COG0395	ABC-type sugar transport system, permease component
HC659_29690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC659_29700	COG2124	cytochrome p450
HC659_29710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HC659_29730	COG0156	8-amino-7-oxononanoate synthase activity
HC659_29740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC659_29760	COG1073	alpha beta
HC659_29770	COG1609	Transcriptional regulator
HC659_29780	COG1653	transport
HC659_29790	COG1175	transmembrane transport
HC659_29800	COG0395	ABC-type sugar transport system, permease component
HC659_29810	COG1486	melibiose metabolic process
HC659_29820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC659_29830	COG0495	leucyl-tRNA aminoacylation
HC659_29850	COG2202	Pas domain
HC659_29850	COG1366	Belongs to the anti-sigma-factor antagonist family
HC659_29860	COG2814	Major facilitator Superfamily
HC659_29870	COG2433	Pfam Transposase IS66
HC659_29880	COG0577	efflux transmembrane transporter activity
HC659_29890	COG1136	(ABC) transporter
HC659_29900	COG2205	protein histidine kinase activity
HC659_29910	COG0745	RESPONSE REGULATOR receiver
HC659_29920	COG0577	efflux transmembrane transporter activity
HC659_29930	COG1136	(ABC) transporter
HC659_29960	COG1131	(ABC) transporter
HC659_29970	COG1725	Transcriptional regulator
HC659_29990	COG1242	4 iron, 4 sulfur cluster binding
HC659_30000	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC659_30020	COG2267	carboxylic ester hydrolase activity
HC659_30030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC659_30040	COG1113	amino acid transport
HC659_30050	COG0367	asparagine synthase
HC659_30060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC659_30070	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HC659_30090	COG1506	peptidase
HC659_30100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC659_30110	COG1116	anion transmembrane transporter activity
HC659_30120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC659_30130	COG0494	nUDIX hydrolase
HC659_30140	COG4824	toxin secretion phage lysis holin
HC659_30150	COG0783	Belongs to the Dps family
HC659_30170	COG1854	S-ribosylhomocysteine lyase activity
HC659_30180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC659_30190	COG0288	reversible hydration of carbon dioxide
HC659_30200	COG0254	rRNA binding
HC659_30210	COG1271	oxidase subunit
HC659_30220	COG1294	oxidase, subunit
HC659_30240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC659_30250	COG1321	iron dependent repressor
HC659_30250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC659_30260	COG1121	(ABC) transporter
HC659_30270	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC659_30280	COG4948	Mandelate Racemase Muconate Lactonizing
HC659_30290	COG0318	PFAM AMP-dependent synthetase and ligase
HC659_30300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HC659_30310	COG0596	Alpha beta hydrolase
HC659_30320	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HC659_30330	COG1169	isochorismate synthase
HC659_30340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC659_30350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC659_30360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC659_30370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC659_30380	COG0438	transferase activity, transferring glycosyl groups
HC659_30400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC659_30410	COG0438	transferase activity, transferring glycosyl groups
HC659_30420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC659_30430	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HC659_30440	COG0058	SHG alpha-glucan phosphorylase activity
HC659_30450	COG0297	glycogen (starch) synthase activity
HC659_30460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC659_30470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC659_30480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HC659_30730	COG3859	Proton-coupled thiamine transporter YuaJ
HC659_30740	COG1247	-acetyltransferase
HC659_30750	COG2268	Band 7 protein
HC659_30760	COG1585	Membrane protein implicated in regulation of membrane protease activity
HC659_30770	COG2318	DinB family
HC659_30790	COG1454	alcohol dehydrogenase
HC659_30800	COG1012	belongs to the aldehyde dehydrogenase family
HC659_30810	COG1510	regulation of RNA biosynthetic process
HC659_30830	COG0569	domain protein
HC659_30840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC659_30850	COG4682	membrane
HC659_30860	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC659_30870	COG0477	Major facilitator Superfamily
HC659_30880	COG5553	Cysteine dioxygenase type I
HC659_30900	COG1968	undecaprenyl-diphosphatase activity
HC659_30910	COG0628	permease
HC659_30920	COG0673	inositol 2-dehydrogenase activity
HC659_30930	COG4806	L-rhamnose isomerase
HC659_30940	COG3254	rhamnose metabolic process
HC659_30950	COG1070	Carbohydrate kinase
HC659_30960	COG1349	DNA-binding transcription factor activity
HC659_30970	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_30970	COG3347	Dehydrogenase
HC659_30980	COG0840	transmembrane signaling receptor activity
HC659_30990	COG0840	transmembrane signaling receptor activity
HC659_31000	COG0840	transmembrane signaling receptor activity
HC659_31010	COG0840	transmembrane signaling receptor activity
HC659_31040	COG0432	Pfam Uncharacterised protein family UPF0047
HC659_31050	COG0366	Alpha amylase catalytic
HC659_31060	COG1253	flavin adenine dinucleotide binding
HC659_31070	COG2738	Putative neutral zinc metallopeptidase
HC659_31100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC659_31130	COG0166	Belongs to the GPI family
HC659_31140	COG1979	alcohol dehydrogenase
HC659_31150	COG1979	alcohol dehydrogenase
HC659_31160	COG2155	Conserved Protein
HC659_31170	COG1098	S1 RNA binding domain
HC659_31190	COG0436	Aminotransferase
HC659_31200	COG1522	sequence-specific DNA binding
HC659_31210	COG2267	carboxylic ester hydrolase activity
HC659_31230	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC659_31240	COG2205	protein histidine kinase activity
HC659_31260	COG5018	Exonuclease
HC659_31280	COG2814	Major facilitator Superfamily
HC659_31290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC659_31300	COG3011	Protein conserved in bacteria
HC659_31320	COG3290	protein histidine kinase activity
HC659_31330	COG4565	transcriptional regulatory protein
HC659_31380	COG3493	citrate carrier protein
HC659_31400	COG2111	Na H antiporter
HC659_31400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC659_31410	COG2111	Na H antiporter
HC659_31420	COG1006	Multisubunit Na H antiporter MnhC subunit
HC659_31430	COG0651	ATP synthesis coupled electron transport
HC659_31440	COG1863	multisubunit Na H antiporter MnhE subunit
HC659_31450	COG2212	antiporter activity
HC659_31460	COG1320	monovalent cation:proton antiporter activity
HC659_31470	COG2050	protein possibly involved in aromatic compounds catabolism
HC659_31480	COG2197	response regulator
HC659_31490	COG4585	Histidine kinase
HC659_31510	COG0142	geranyltranstransferase activity
HC659_31540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HC659_31550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HC659_31560	COG1335	isochorismatase
HC659_31570	COG5506	Protein of unknown function (DUF1694)
HC659_31600	COG0628	permease
HC659_31630	COG1418	mRNA catabolic process
HC659_31640	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_31660	COG1511	domain protein
HC659_31670	COG1674	ftsk spoiiie
HC659_31670	COG0433	COG0433 Predicted ATPase
HC659_31680	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC659_31690	COG5417	Belongs to the EsaB family
HC659_31700	COG4842	Belongs to the WXG100 family
HC659_31720	COG2508	Transcriptional regulator
HC659_31720	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC659_31730	COG0686	Belongs to the AlaDH PNT family
HC659_31740	COG5634	Uncharacterized conserved protein (DUF2278)
HC659_31750	COG3251	PFAM MbtH domain protein
HC659_31760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_31770	COG3433	isochorismatase activity
HC659_31770	COG1535	isochorismatase
HC659_31780	COG1021	2,3-dihydroxybenzoate-AMP ligase
HC659_31790	COG1169	isochorismate synthase
HC659_31800	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_31810	COG2819	hydrolase of the alpha beta superfamily
HC659_31820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC659_31830	COG1268	BioY protein
HC659_31840	COG2056	Na+-H+ antiporter family
HC659_31850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HC659_31860	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HC659_31870	COG3584	3D domain protein
HC659_31900	COG1252	NADH dehydrogenase
HC659_31910	COG0492	ferredoxin-NADP+ reductase activity
HC659_31930	COG0516	GMP reductase activity
HC659_31940	COG2808	Putative FMN-binding domain
HC659_31950	COG0456	acetyltransferase
HC659_31960	COG0316	Belongs to the HesB IscA family
HC659_31970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HC659_31980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC659_31990	COG4844	belongs to the
HC659_32000	COG1252	NADH dehydrogenase
HC659_32010	COG4837	Protein of unknown function (DUF1462)
HC659_32020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HC659_32030	COG1506	peptidase
HC659_32030	COG4946	Tricorn protease homolog
HC659_32030	COG0823	Involved in the tonB-independent uptake of proteins
HC659_32040	COG0083	homoserine kinase activity
HC659_32050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC659_32060	COG0460	homoserine dehydrogenase
HC659_32070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC659_32080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC659_32090	COG0647	UMP catabolic process
HC659_32100	COG2445	Protein of unknown function DUF86
HC659_32110	COG4470	Protein conserved in bacteria
HC659_32130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HC659_32140	COG0739	heme binding
HC659_32160	COG3377	Domain of unknown function (DUF1805)
HC659_32170	COG0737	Belongs to the 5'-nucleotidase family
HC659_32180	COG0730	response to heat
HC659_32190	COG1801	Protein of unknown function DUF72
HC659_32210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC659_32220	COG2508	Transcriptional regulator
HC659_32230	COG2233	PERMEase
HC659_32240	COG2233	PERMEase
HC659_32250	COG3648	Uricase
HC659_32250	COG3195	allantoin biosynthetic process
HC659_32260	COG2351	hydroxyisourate hydrolase activity
HC659_32280	COG2080	2 iron, 2 sulfur cluster binding
HC659_32290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC659_32300	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HC659_32310	COG2068	MobA-Related Protein
HC659_32320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HC659_32330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC659_32340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC659_32350	COG2356	endonuclease I
HC659_32360	COG3842	ATPase activity
HC659_32370	COG2188	Transcriptional regulator
HC659_32380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC659_32390	COG0395	ABC-type sugar transport system, permease component
HC659_32400	COG1175	transmembrane transport
HC659_32410	COG1653	transport
HC659_32420	COG2222	sugar isomerase
HC659_32430	COG0322	excinuclease ABC activity
HC659_32440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC659_32460	COG0346	lactoylglutathione lyase activity
HC659_32470	COG0719	Fe-S assembly protein
HC659_32480	COG0822	iron-sulfur transferase activity
HC659_32490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC659_32500	COG0719	Fe-S assembly protein
HC659_32510	COG0396	ATPase activity
HC659_32530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC659_32540	COG1464	Belongs to the NlpA lipoprotein family
HC659_32550	COG2011	ABC-type metal ion transport system permease component
HC659_32560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC659_32580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC659_32590	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC659_32610	COG0509	glycine decarboxylation via glycine cleavage system
HC659_32620	COG1393	Belongs to the ArsC family
HC659_32630	COG1960	acyl-CoA dehydrogenase activity
HC659_32640	COG0183	Belongs to the thiolase family
HC659_32650	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC659_32650	COG1024	Enoyl-CoA hydratase
HC659_32670	COG0506	proline dehydrogenase activity
HC659_32690	COG5577	PFAM Coat F domain
HC659_32700	COG1846	Transcriptional regulator
HC659_32710	COG0477	Major facilitator Superfamily
HC659_32720	COG1942	4-Oxalocrotonate Tautomerase
HC659_32730	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_32740	COG0583	DNA-binding transcription factor activity
HC659_32760	COG1120	ATPase activity
HC659_32790	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_32800	COG0783	Belongs to the Dps family
HC659_32810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC659_32820	COG0745	RESPONSE REGULATOR receiver
HC659_32830	COG2205	protein histidine kinase activity
HC659_32830	COG2770	Histidine kinase
HC659_32850	COG1309	transcriptional regulator
HC659_32860	COG0114	fumarate hydratase activity
HC659_32880	COG0697	spore germination
HC659_32890	COG0814	amino acid
HC659_32910	COG2197	response regulator
HC659_32920	COG4585	Histidine kinase
HC659_32930	COG4758	membrane
HC659_32940	COG3595	metallopeptidase activity
HC659_32950	COG1842	Phage shock protein A
HC659_32960	COG4758	membrane
HC659_32970	COG2814	Major facilitator Superfamily
HC659_32980	COG2096	Adenosyltransferase
HC659_32990	COG1120	ATPase activity
HC659_33000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_33010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC659_33020	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_33030	COG3386	PFAM SMP-30 Gluconolaconase
HC659_33040	COG2205	protein histidine kinase activity
HC659_33050	COG0745	RESPONSE REGULATOR receiver
HC659_33070	COG1191	sigma factor activity
HC659_33090	COG2140	Oxalate decarboxylase
HC659_33110	COG0577	efflux transmembrane transporter activity
HC659_33120	COG1136	(ABC) transporter
HC659_33130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC659_33140	COG1120	ATPase activity
HC659_33150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_33160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC659_33170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC659_33190	COG0531	amino acid
HC659_33210	COG1988	membrane-bound metal-dependent
HC659_33220	COG1368	sulfuric ester hydrolase activity
HC659_33230	COG1910	domain protein
HC659_33240	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC659_33250	COG4149	molybdate abc transporter
HC659_33260	COG0656	L-ascorbic acid biosynthetic process
HC659_33280	COG0025	NhaP-type Na H and K H
HC659_33290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC659_33300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC659_33310	COG3973	AAA domain
HC659_33330	COG2860	membrane
HC659_33340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HC659_33350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC659_33360	COG2217	Heavy metal translocating P-type atpase
HC659_33370	COG2217	Heavy metal translocating P-type atpase
HC659_33380	COG2608	mercury ion transmembrane transporter activity
HC659_33390	COG1937	Protein conserved in bacteria
HC659_33400	COG0673	inositol 2-dehydrogenase activity
HC659_33410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC659_33420	COG1289	transmembrane transporter activity
HC659_33440	COG2076	Multidrug Resistance protein
HC659_33450	COG1309	transcriptional regulator
HC659_33460	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_33470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HC659_33480	COG0557	exoribonuclease II activity
HC659_33490	COG1647	Serine aminopeptidase, S33
HC659_33500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC659_33510	COG0596	Alpha beta hydrolase
HC659_33520	COG1396	sequence-specific DNA binding
HC659_33530	COG1396	sequence-specific DNA binding
HC659_33540	COG1733	regulation of RNA biosynthetic process
HC659_33550	COG0840	transmembrane signaling receptor activity
HC659_33560	COG1174	glycine betaine transport
HC659_33570	COG1732	Glycine betaine
HC659_33580	COG1174	glycine betaine transport
HC659_33590	COG0517	IMP dehydrogenase activity
HC659_33590	COG1125	glycine betaine transport
HC659_33600	COG1510	regulation of RNA biosynthetic process
HC659_33640	COG5658	integral membrane protein
HC659_33650	COG0640	Transcriptional regulator
HC659_33660	COG1174	glycine betaine transport
HC659_33670	COG1732	Glycine betaine
HC659_33680	COG1174	glycine betaine transport
HC659_33690	COG1125	glycine betaine transport
HC659_33690	COG0517	IMP dehydrogenase activity
HC659_33700	COG1510	regulation of RNA biosynthetic process
HC659_33710	COG2095	MarC family integral membrane protein
HC659_33730	COG3064	Membrane
HC659_33740	COG4640	response to antibiotic
HC659_33750	COG0456	acetyltransferase
HC659_33760	COG0148	phosphopyruvate hydratase activity
HC659_33770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HC659_33780	COG0149	triose-phosphate isomerase activity
HC659_33790	COG0126	phosphoglycerate kinase activity
HC659_33800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC659_33810	COG2390	Transcriptional regulator
HC659_33820	COG2814	Major facilitator Superfamily
HC659_33830	COG1609	Transcriptional regulator
HC659_33840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC659_33850	COG0583	DNA-binding transcription factor activity
HC659_33860	COG0697	spore germination
HC659_33870	COG1113	amino acid transport
HC659_33880	COG3858	chitin binding
HC659_33890	COG1556	Lactate utilization protein
HC659_33900	COG1139	Iron-sulfur cluster binding protein
HC659_33910	COG0247	lactate metabolic process
HC659_33920	COG2197	response regulator
HC659_33930	COG4585	Histidine kinase
HC659_33940	COG0842	Transport permease protein
HC659_33950	COG1131	(ABC) transporter
HC659_33960	COG0596	Alpha beta hydrolase
HC659_33970	COG2208	phosphoserine phosphatase activity
HC659_33980	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HC659_33990	COG1874	Beta-galactosidase
HC659_34000	COG3833	ABC-type maltose transport systems, permease component
HC659_34010	COG1175	transmembrane transport
HC659_34020	COG2182	Extracellular solute-binding protein
HC659_34030	COG1609	Transcriptional regulator
HC659_34040	COG2186	Transcriptional regulator
HC659_34050	COG1620	l-lactate permease
HC659_34060	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC659_34080	COG5039	Polysaccharide pyruvyl transferase
HC659_34090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC659_34100	COG0110	maltose O-acetyltransferase activity
HC659_34110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC659_34120	COG2244	polysaccharide biosynthetic process
HC659_34130	COG1216	Glycosyl transferase, family 2
HC659_34140	COG5039	Polysaccharide pyruvyl transferase
HC659_34150	COG1216	Glycosyl transferase, family 2
HC659_34170	COG0438	transferase activity, transferring glycosyl groups
HC659_34180	COG1215	transferase activity, transferring glycosyl groups
HC659_34190	COG0438	transferase activity, transferring glycosyl groups
HC659_34200	COG1086	Polysaccharide biosynthesis protein
HC659_34210	COG0489	protein tyrosine kinase activity
HC659_34220	COG3944	biosynthesis protein
HC659_34230	COG1396	sequence-specific DNA binding
HC659_34240	COG2272	Belongs to the type-B carboxylesterase lipase family
HC659_34260	COG3479	Phenolic acid decarboxylase
HC659_34280	COG1794	racemase activity, acting on amino acids and derivatives
HC659_34290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC659_34300	COG1621	beta-fructofuranosidase activity
HC659_34310	COG1621	beta-fructofuranosidase activity
HC659_34320	COG0531	amino acid
HC659_34330	COG1309	transcriptional regulator
HC659_34340	COG2076	Multidrug Resistance protein
HC659_34350	COG2076	Multidrug Resistance protein
HC659_34370	COG0277	FAD linked oxidase domain protein
HC659_34380	COG3621	Patatin-like phospholipase
HC659_34400	COG0740	serine-type endopeptidase activity
HC659_34410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC659_34420	COG0366	Alpha amylase catalytic
HC659_34430	COG1554	hydrolase, family 65, central catalytic
HC659_34440	COG5521	maltodextrose utilization protein MalA
HC659_34450	COG3833	ABC-type maltose transport systems, permease component
HC659_34460	COG1175	transmembrane transport
HC659_34470	COG2182	Extracellular solute-binding protein
HC659_34480	COG0366	Alpha amylase catalytic
HC659_34490	COG1609	Transcriptional regulator
HC659_34500	COG1611	Belongs to the LOG family
HC659_34510	COG1694	Mazg nucleotide pyrophosphohydrolase
HC659_34520	COG0659	secondary active sulfate transmembrane transporter activity
HC659_34530	COG0288	reversible hydration of carbon dioxide
HC659_34540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC659_34550	COG0577	efflux transmembrane transporter activity
HC659_34560	COG1136	(ABC) transporter
HC659_34570	COG5002	protein histidine kinase activity
HC659_34580	COG0745	RESPONSE REGULATOR receiver
HC659_34600	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HC659_34610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC659_34620	COG1481	regulation of sporulation
HC659_34630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC659_34640	COG1660	Displays ATPase and GTPase activities
HC659_34650	COG1051	belongs to the nudix hydrolase family
HC659_34660	COG0492	ferredoxin-NADP+ reductase activity
HC659_34670	COG0791	NLP P60 protein
HC659_34670	COG3883	PFAM NLP P60 protein
HC659_34680	COG0457	Tetratricopeptide repeat
HC659_34690	COG1132	(ABC) transporter
HC659_34730	COG0140	phosphoribosyl-ATP diphosphatase activity
HC659_34730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HC659_34740	COG0107	imidazoleglycerol-phosphate synthase activity
HC659_34750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HC659_34760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC659_34770	COG0131	Imidazoleglycerol-phosphate dehydratase
HC659_34780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HC659_34790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HC659_34800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HC659_34810	COG4990	cell redox homeostasis
HC659_34820	COG5297	Belongs to the glycosyl hydrolase family 6
HC659_34830	COG0110	maltose O-acetyltransferase activity
HC659_34840	COG0546	phosphoglycolate phosphatase activity
HC659_34850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HC659_34860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC659_34870	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HC659_34880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC659_34890	COG0363	glucosamine-6-phosphate deaminase activity
HC659_34900	COG2188	Transcriptional regulator
HC659_34910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC659_34920	COG1846	Transcriptional regulator
HC659_34930	COG2124	cytochrome p450
HC659_34950	COG1846	Transcriptional regulator
HC659_34960	COG2814	Major facilitator Superfamily
HC659_34970	COG1950	PFAM Membrane protein of
HC659_34980	COG1983	PspC domain protein
HC659_34990	COG3595	metallopeptidase activity
HC659_35020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC659_35030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC659_35040	COG0556	nucleotide-excision repair
HC659_35050	COG4897	Protein conserved in bacteria
HC659_35060	COG3848	Pyruvate phosphate dikinase
HC659_35060	COG0574	Belongs to the PEP-utilizing enzyme family
HC659_35070	COG1309	transcriptional regulator
HC659_35080	COG2814	Major facilitator Superfamily
HC659_35090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC659_35110	COG3409	Peptidoglycan-binding domain 1 protein
HC659_35110	COG0793	Belongs to the peptidase S41A family
HC659_35120	COG2177	Part of the ABC transporter FtsEX involved in
HC659_35130	COG2884	Cell division ATP-binding protein ftsE
HC659_35140	COG2010	Cytochrome c
HC659_35150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC659_35160	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HC659_35170	COG0653	protein targeting
HC659_35180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC659_35210	COG1516	flagellar protein fliS
HC659_35220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HC659_35230	COG1334	flagellar protein FlaG
HC659_35240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC659_35250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC659_35260	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HC659_35280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC659_35290	COG1256	bacterial-type flagellum assembly
HC659_35290	COG4786	Flagellar basal body rod
HC659_35300	COG3418	PFAM FlgN family protein
HC659_35310	COG2747	anti-sigma28 factor FlgM
HC659_35330	COG1040	competence protein
HC659_35350	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HC659_35360	COG1307	EDD domain protein, DegV family
HC659_35370	COG2197	response regulator
HC659_35380	COG4585	Histidine kinase
HC659_35390	COG1739	Uncharacterized protein family UPF0029
HC659_35400	COG1316	TRANSCRIPTIONal
HC659_35410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC659_35420	COG0438	transferase activity, transferring glycosyl groups
HC659_35430	COG1215	transferase activity, transferring glycosyl groups
HC659_35440	COG3206	protein involved in exopolysaccharide biosynthesis
HC659_35450	COG3307	-O-antigen
HC659_35460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC659_35470	COG0297	glycogen (starch) synthase activity
HC659_35470	COG0438	transferase activity, transferring glycosyl groups
HC659_35480	COG2244	polysaccharide biosynthetic process
HC659_35500	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC659_35500	COG2247	cell wall binding repeat
HC659_35510	COG2247	cell wall binding repeat
HC659_35510	COG2385	sporulation resulting in formation of a cellular spore
HC659_35530	COG1316	TRANSCRIPTIONal
HC659_35540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HC659_35550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC659_35560	COG1682	transport, permease protein
HC659_35570	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC659_35570	COG1215	transferase activity, transferring glycosyl groups
HC659_35580	COG0463	Glycosyl transferase, family 2
HC659_35600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC659_35610	COG1134	teichoic acid transport
HC659_35620	COG1682	transport, permease protein
HC659_35630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC659_35640	COG0438	transferase activity, transferring glycosyl groups
HC659_35650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HC659_35660	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HC659_35670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC659_35690	COG4193	domain, Protein
HC659_35700	COG1482	cell wall glycoprotein biosynthetic process
HC659_35710	COG0697	spore germination
HC659_35720	COG0814	amino acid
HC659_35740	COG2814	Major facilitator Superfamily
HC659_35750	COG1316	TRANSCRIPTIONal
HC659_35760	COG0561	phosphatase activity
HC659_35770	COG0791	NLP P60 protein
HC659_35790	COG2843	Capsule synthesis protein
HC659_35810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC659_35820	COG1609	Transcriptional regulator
HC659_35830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC659_35840	COG1869	D-ribose catabolic process
HC659_35850	COG1129	ABC transporter
HC659_35860	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC659_35870	COG1879	ABC-type sugar transport system periplasmic component
HC659_35880	COG3103	Sh3 type 3 domain protein
HC659_35900	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC659_35910	COG3527	Alpha-acetolactate decarboxylase
HC659_35920	COG0028	Belongs to the TPP enzyme family
HC659_35930	COG0583	DNA-binding transcription factor activity
HC659_35940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC659_35970	COG5337	Spore coat protein CotH
HC659_35990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC659_36010	COG0405	Gamma-glutamyltransferase
HC659_36020	COG1522	sequence-specific DNA binding
HC659_36030	COG2059	Chromate
HC659_36040	COG2059	Chromate
HC659_36060	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC659_36070	COG0583	DNA-binding transcription factor activity
HC659_36080	COG1515	deoxyribonuclease V activity
HC659_36100	COG5444	nuclease activity
HC659_36140	COG3878	Protein conserved in bacteria
HC659_36150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC659_36160	COG4464	protein tyrosine phosphatase activity
HC659_36170	COG0489	protein tyrosine kinase activity
HC659_36180	COG3944	biosynthesis protein
HC659_36200	COG4715	Zinc finger, swim domain protein
HC659_36210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC659_36220	COG0561	phosphatase activity
HC659_36230	COG1349	DNA-binding transcription factor activity
HC659_36240	COG0629	single-stranded DNA binding
HC659_36270	COG3764	Sortase (surface protein transpeptidase)
HC659_36290	COG0745	RESPONSE REGULATOR receiver
HC659_36290	COG2972	Histidine kinase
HC659_36300	COG1970	mechanosensitive ion channel activity
HC659_36310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC659_36320	COG0457	Tetratricopeptide repeat
HC659_36330	COG4786	Flagellar basal body rod
HC659_36340	COG4786	Flagellar basal body rod
HC659_36350	COG1077	Cell shape determining protein MreB Mrl
HC659_36360	COG1609	Transcriptional regulator
HC659_36370	COG1846	Transcriptional regulator
HC659_36380	COG2814	Major facilitator Superfamily
HC659_36390	COG3420	alginic acid biosynthetic process
HC659_36400	COG1953	Uracil, thiamine, allantoin
HC659_36410	COG0477	Major facilitator Superfamily
HC659_36420	COG1335	isochorismatase
HC659_36440	COG0004	ammonium transporteR
HC659_36450	COG0347	Belongs to the P(II) protein family
HC659_36460	COG0671	phosphoesterase, PA-phosphatase related
HC659_36480	COG0739	heme binding
HC659_36490	COG1247	-acetyltransferase
HC659_36520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC659_36530	COG0789	Transcriptional regulator
HC659_36550	COG2910	NAD(P)H-binding
HC659_36560	COG1959	2 iron, 2 sulfur cluster binding
HC659_36570	COG0804	urea catabolic process
HC659_36580	COG0832	Belongs to the urease beta subunit family
HC659_36590	COG0831	urea catabolic process
HC659_36620	COG3237	CsbD-like
HC659_36630	COG1994	Peptidase M50
HC659_36640	COG0457	Tetratricopeptide repeat
HC659_36650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC659_36660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HC659_36680	COG2304	oxidoreductase activity
HC659_36690	COG2304	oxidoreductase activity
HC659_36700	COG2385	sporulation resulting in formation of a cellular spore
HC659_36710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC659_36730	COG4836	Membrane
HC659_36750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HC659_36760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC659_36770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HC659_36780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HC659_36790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC659_36800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC659_36820	COG0356	it plays a direct role in the translocation of protons across the membrane
HC659_36840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HC659_36850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC659_36860	COG4475	Protein of unknown function (DUF436)
HC659_36870	COG0698	ribose 5-phosphate isomerase
HC659_36880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC659_36890	COG1971	Probably functions as a manganese efflux pump
HC659_36900	COG0009	L-threonylcarbamoyladenylate synthase
HC659_36910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC659_36950	COG2890	protein-(glutamine-N5) methyltransferase activity
HC659_36960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC659_36970	COG0346	lactoylglutathione lyase activity
HC659_36980	COG0789	Transcriptional regulator
HC659_36990	COG0679	Auxin Efflux Carrier
HC659_37000	COG0281	malic enzyme
HC659_37010	COG1435	thymidine kinase activity
HC659_37030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC659_37050	COG1494	fructose-1,6-bisphosphatase
HC659_37060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC659_37070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC659_37080	COG0191	fructose-bisphosphate aldolase activity
HC659_37090	COG2204	response regulator
HC659_37100	COG4821	SIS domain
HC659_37110	COG0504	CTP synthase activity
HC659_37120	COG3343	RNA polymerase activity
HC659_37130	COG1960	acyl-CoA dehydrogenase activity
HC659_37140	COG2181	nitrate reductase activity
HC659_37140	COG0247	lactate metabolic process
HC659_37150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC659_37160	COG4294	response to UV
HC659_37180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC659_37190	COG1132	(ABC) transporter
HC659_37200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC659_37210	COG2181	nitrate reductase activity
HC659_37220	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC659_37230	COG1140	nitrate reductase beta subunit
HC659_37240	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC659_37250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC659_37270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC659_37280	COG2223	nitrite transmembrane transporter activity
HC659_37290	COG0018	arginyl-trna synthetase
HC659_37300	COG4506	Protein conserved in bacteria
HC659_37320	COG0535	radical SAM domain protein
HC659_37340	COG1131	(ABC) transporter
HC659_37350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC659_37360	COG0612	Peptidase, M16
HC659_37370	COG0612	Peptidase, M16
HC659_37390	COG3391	amine dehydrogenase activity
HC659_37400	COG3391	amine dehydrogenase activity
HC659_37410	COG0457	Tetratricopeptide repeat
HC659_37430	COG0010	Belongs to the arginase family
HC659_37440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC659_37450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC659_37470	COG1994	Peptidase M50
HC659_37480	COG1942	4-Oxalocrotonate Tautomerase
HC659_37490	COG1846	Transcriptional regulator
HC659_37500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC659_37520	COG0477	Major facilitator Superfamily
HC659_37530	COG1959	2 iron, 2 sulfur cluster binding
HC659_37540	COG3465	dGTPase activity
HC659_37550	COG1078	dGTPase activity
HC659_37560	COG4844	belongs to the
HC659_37580	COG0697	spore germination
HC659_37600	COG0095	Lipoate-protein ligase
HC659_37610	COG0583	DNA-binding transcription factor activity
HC659_37620	COG0280	phosphate acetyltransferase
HC659_37640	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_37650	COG0436	Aminotransferase
HC659_37660	COG2814	Major facilitator Superfamily
HC659_37670	COG0151	Belongs to the GarS family
HC659_37680	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_37690	COG1917	Cupin 2, conserved barrel domain protein
HC659_37700	COG0077	Prephenate dehydratase
HC659_37710	COG2814	Major facilitator Superfamily
HC659_37720	COG0833	amino acid
HC659_37730	COG4187	Peptidase family M20/M25/M40
HC659_37740	COG1012	belongs to the aldehyde dehydrogenase family
HC659_37750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC659_37770	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC659_37780	COG1091	dTDP-4-dehydrorhamnose reductase activity
HC659_37790	COG1088	dTDP-glucose 4,6-dehydratase activity
HC659_37800	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC659_37810	COG3980	spore coat polysaccharide biosynthesis protein
HC659_37820	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HC659_37830	COG2089	acid synthase
HC659_37840	COG0456	acetyltransferase
HC659_37850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC659_37860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC659_37870	COG0463	Glycosyl transferase, family 2
HC659_37890	COG2363	Small membrane protein
HC659_37900	COG2233	PERMEase
HC659_37920	COG1012	belongs to the aldehyde dehydrogenase family
HC659_37930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC659_37940	COG1216	Glycosyl transferase, family 2
HC659_37950	COG0351	phosphomethylpyrimidine kinase
HC659_37970	COG1621	beta-fructofuranosidase activity
HC659_37980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_37980	COG1263	PTS System
HC659_37990	COG2116	formate transmembrane transporter activity
HC659_38000	COG3711	transcriptional antiterminator
HC659_38020	COG1404	Belongs to the peptidase S8 family
HC659_38030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC659_38040	COG0778	Nitroreductase
HC659_38050	COG0772	Belongs to the SEDS family
HC659_38070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC659_38080	COG1845	cytochrome c oxidase, subunit III
HC659_38090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC659_38100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC659_38110	COG2261	transglycosylase associated protein
HC659_38120	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HC659_38130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC659_38140	COG2246	polysaccharide biosynthetic process
HC659_38150	COG1309	transcriptional regulator
HC659_38170	COG3162	membrane
HC659_38180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC659_38190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HC659_38200	COG2837	iron assimilation
HC659_38210	COG2822	iron ion transport
HC659_38220	COG0672	)-iron permease
HC659_38230	COG0352	thiamine-phosphate diphosphorylase activity
HC659_38240	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HC659_38250	COG0583	DNA-binding transcription factor activity
HC659_38260	COG1380	Effector of murein hydrolase LrgA
HC659_38270	COG1346	cytolysis
HC659_38280	COG2814	Major facilitator Superfamily
HC659_38290	COG4895	conserved protein (DUF2196)
HC659_38300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HC659_38310	COG0346	lactoylglutathione lyase activity
HC659_38340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC659_38350	COG1404	Belongs to the peptidase S8 family
HC659_38360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_38360	COG1263	PTS System
HC659_38370	COG3711	transcriptional antiterminator
HC659_38380	COG1442	glycosyl transferase family 8
HC659_38390	COG5522	Integral membrane protein (intg_mem_TP0381)
HC659_38400	COG1846	Transcriptional regulator
HC659_38410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC659_38420	COG2234	aminopeptidase activity
HC659_38450	COG2814	Major facilitator Superfamily
HC659_38460	COG2357	RelA SpoT domain protein
HC659_38470	COG1575	Belongs to the MenA family. Type 1 subfamily
HC659_38490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC659_38500	COG1696	Membrane protein involved in D-alanine export
HC659_38510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC659_38520	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HC659_38530	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HC659_38540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC659_38550	COG1486	melibiose metabolic process
HC659_38560	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC659_38570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC659_38580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC659_38590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC659_38590	COG3711	transcriptional antiterminator
HC659_38610	COG2094	Belongs to the DNA glycosylase MPG family
HC659_38620	COG0753	catalase activity
HC659_38630	COG2814	Major facilitator Superfamily
HC659_38640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC659_38650	COG1131	(ABC) transporter
HC659_38690	COG1595	DNA-templated transcription, initiation
HC659_38700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC659_38710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC659_38720	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC659_38730	COG4988	ABC transporter
HC659_38740	COG1294	oxidase, subunit
HC659_38750	COG1271	oxidase subunit
HC659_38760	COG3493	citrate carrier protein
HC659_38770	COG0501	Belongs to the peptidase M48B family
HC659_38780	COG0726	polysaccharide deacetylase
HC659_38790	COG3842	ATPase activity
HC659_38800	COG2508	Transcriptional regulator
HC659_38810	COG1012	belongs to the aldehyde dehydrogenase family
HC659_38820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC659_38840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HC659_38860	COG4585	Histidine kinase
HC659_38870	COG2197	response regulator
HC659_38880	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC659_38900	COG4894	glucomannan catabolic process
HC659_38910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC659_38920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC659_38930	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_38940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC659_38950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC659_38960	COG2610	gluconate transmembrane transporter activity
HC659_38970	COG0500	methyltransferase
HC659_38980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC659_39010	COG0753	catalase activity
HC659_39010	COG0693	protein deglycase activity
HC659_39020	COG2851	Citrate transporter
HC659_39030	COG2273	Hydrolase Family 16
HC659_39040	COG3711	transcriptional antiterminator
HC659_39060	COG2270	Major facilitator Superfamily
HC659_39070	COG0513	Belongs to the DEAD box helicase family
HC659_39080	COG2755	lipolytic protein G-D-S-L family
HC659_39080	COG3401	FG-GAP repeat protein
HC659_39190	COG3209	COG3209 Rhs family protein
HC659_39200	COG0697	spore germination
HC659_39210	COG0589	response to stress
HC659_39220	COG2723	6-phospho-beta-galactosidase activity
HC659_39230	COG1263	PTS System
HC659_39230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_39230	COG2190	(PTS) system
HC659_39260	COG5444	nuclease activity
HC659_39290	COG5444	nuclease activity
HC659_39320	COG3507	Belongs to the glycosyl hydrolase 43 family
HC659_39350	COG2986	histidine ammonia-lyase
HC659_39360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HC659_39370	COG1228	amidohydrolase
HC659_39380	COG0010	Belongs to the arginase family
HC659_39390	COG0833	amino acid
HC659_39400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HC659_39410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC659_39420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HC659_39430	COG2390	Transcriptional regulator
HC659_39450	COG3192	ethanolamine utilization protein
HC659_39460	COG2079	MmgE PrpD family protein
HC659_39470	COG1473	amidohydrolase
HC659_39480	COG1126	abc transporter atp-binding protein
HC659_39490	COG0765	amino acid transport
HC659_39500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC659_39510	COG0456	acetyltransferase
HC659_39520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC659_39530	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC659_39540	COG0561	phosphatase activity
HC659_39600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC659_39610	COG5294	Protein conserved in bacteria
HC659_39620	COG0577	efflux transmembrane transporter activity
HC659_39630	COG1136	(ABC) transporter
HC659_39640	COG2205	protein histidine kinase activity
HC659_39650	COG0745	RESPONSE REGULATOR receiver
HC659_39660	COG0191	fructose-bisphosphate aldolase activity
HC659_39670	COG1082	Xylose isomerase domain protein TIM barrel
HC659_39680	COG1082	Xylose isomerase domain protein TIM barrel
HC659_39690	COG0673	inositol 2-dehydrogenase activity
HC659_39700	COG2814	Major facilitator Superfamily
HC659_39710	COG1082	Xylose isomerase domain protein TIM barrel
HC659_39720	COG3962	Belongs to the TPP enzyme family
HC659_39730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC659_39740	COG3718	enzyme involved in inositol metabolism
HC659_39750	COG1012	belongs to the aldehyde dehydrogenase family
HC659_39760	COG1349	DNA-binding transcription factor activity
HC659_39770	COG0667	Aldo Keto reductase
HC659_39810	COG2814	Major facilitator Superfamily
HC659_39820	COG0326	Molecular chaperone. Has ATPase activity
HC659_39840	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_39850	COG1309	transcriptional regulator
HC659_39860	COG1012	belongs to the aldehyde dehydrogenase family
HC659_39880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC659_39900	COG1714	RDD family
HC659_39910	COG2311	Membrane
HC659_39920	COG1917	Cupin 2, conserved barrel domain protein
HC659_39930	COG1309	transcriptional regulator
HC659_39940	COG1028	Short-chain dehydrogenase reductase Sdr
HC659_39950	COG1846	Transcriptional regulator
HC659_39960	COG1380	Effector of murein hydrolase LrgA
HC659_39970	COG1346	cytolysis
HC659_39980	COG5039	Polysaccharide pyruvyl transferase
HC659_39990	COG1929	Belongs to the glycerate kinase type-1 family
HC659_40000	COG1802	Transcriptional regulator
HC659_40010	COG1070	Carbohydrate kinase
HC659_40020	COG2610	gluconate transmembrane transporter activity
HC659_40030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC659_40040	COG0450	alkyl hydroperoxide reductase
HC659_40050	COG3634	alkyl hydroperoxide reductase activity
HC659_40060	COG2723	6-phospho-beta-galactosidase activity
HC659_40070	COG2190	(PTS) system
HC659_40070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC659_40070	COG1263	PTS System
HC659_40080	COG2188	Transcriptional regulator
HC659_40100	COG1131	(ABC) transporter
HC659_40110	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HC659_40130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HC659_40160	COG1063	alcohol dehydrogenase
HC659_40200	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HC659_40210	COG0456	acetyltransferase
HC659_40220	COG0457	Tetratricopeptide repeat
HC659_40240	COG0010	Belongs to the arginase family
HC659_40250	COG0833	amino acid
HC659_40260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC659_40270	COG3829	transcription factor binding
HC659_40280	COG5002	protein histidine kinase activity
HC659_40320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC659_40330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC659_40340	COG4853	Protein conserved in bacteria
HC659_40350	COG4863	YycH protein
HC659_40360	COG5002	protein histidine kinase activity
HC659_40370	COG0745	RESPONSE REGULATOR receiver
HC659_40430	COG0346	lactoylglutathione lyase activity
HC659_40440	COG0305	Participates in initiation and elongation during chromosome replication
HC659_40470	COG3093	addiction module antidote protein HigA
HC659_40480	COG2807	transmembrane transport
HC659_40490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC659_40500	COG0359	binds to the 23S rRNA
HC659_40510	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HC659_40520	COG4241	membrane
HC659_40540	COG5577	PFAM Coat F domain
HC659_40550	COG1733	regulation of RNA biosynthetic process
HC659_40560	COG1227	inorganic diphosphatase activity
HC659_40590	COG2271	Major facilitator Superfamily
HC659_40610	COG4319	ketosteroid isomerase
HC659_40620	COG2271	Major facilitator Superfamily
HC659_40680	COG1131	(ABC) transporter
HC659_40700	COG4319	ketosteroid isomerase
HC659_40710	COG1357	PFAM Pentapeptide repeats (8 copies)
HC659_40720	COG2814	Major facilitator Superfamily
HC659_40730	COG0583	DNA-binding transcription factor activity
HC659_40740	COG2153	protein acetylation
HC659_40760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC659_40770	COG1846	Transcriptional regulator
HC659_40780	COG2153	protein acetylation
HC659_40790	COG2364	Membrane
HC659_40800	COG0456	acetyltransferase
HC659_40810	COG2315	Protein conserved in bacteria
HC659_40820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC659_40830	COG2814	Major facilitator Superfamily
HC659_40840	COG1331	Highly conserved protein containing a thioredoxin domain
HC659_40870	COG0789	Transcriptional regulator
HC659_40880	COG0697	spore germination
HC659_40890	COG1331	Highly conserved protein containing a thioredoxin domain
HC659_40900	COG1280	lysine exporter protein (LysE YggA)
HC659_40910	COG1331	Highly conserved protein containing a thioredoxin domain
HC659_40920	COG1331	Highly conserved protein containing a thioredoxin domain
HC659_40930	COG1266	CAAX protease self-immunity
HC659_40940	COG2814	Major facilitator Superfamily
HC659_40940	COG0477	Major facilitator Superfamily
HC659_40950	COG0110	maltose O-acetyltransferase activity
HC659_40960	COG0346	lactoylglutathione lyase activity
HC659_40970	COG1609	Transcriptional regulator
HC659_40980	COG0708	Exodeoxyribonuclease III
HC659_40990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC659_41000	COG0629	single-stranded DNA binding
HC659_41010	COG0360	Binds together with S18 to 16S ribosomal RNA
HC659_41020	COG0012	GTP binding
HC659_41030	COG0243	molybdopterin cofactor binding
HC659_41040	COG4481	Protein conserved in bacteria
HC659_41050	COG3949	Membrane
HC659_41070	COG1475	DNA binding
HC659_41080	COG1192	Involved in chromosome partitioning
HC659_41100	COG1475	DNA binding
HC659_41110	COG0357	Ribosomal RNA small subunit methyltransferase G
HC659_41120	COG0445	tRNA wobble uridine modification
HC659_41130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HC659_41140	COG1847	R3H domain protein
HC659_41150	COG0706	membrane insertase activity
HC659_41160	COG0594	ribonuclease P activity