locus-tag	class	description
A8O17_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8O17_00010	COG0592	DNA-directed DNA polymerase activity
A8O17_00015	COG2501	S4 domain
A8O17_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8O17_00030	COG0187	DNA topoisomerase II activity
A8O17_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8O17_00070	COG0516	GMP reductase activity
A8O17_00070	COG0517	IMP dehydrogenase activity
A8O17_00075	COG1686	Belongs to the peptidase S11 family
A8O17_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A8O17_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A8O17_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8O17_00100	COG1428	Deoxynucleoside kinase
A8O17_00105	COG1428	Deoxynucleoside kinase
A8O17_00110	COG3858	chitin binding
A8O17_00110	COG1388	LysM domain
A8O17_00115	COG1335	isochorismatase
A8O17_00120	COG0590	tRNA wobble adenosine to inosine editing
A8O17_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8O17_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A8O17_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8O17_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
A8O17_00190	COG3853	Toxic anion resistance protein (TelA)
A8O17_00195	COG1982	Orn Lys Arg decarboxylase major
A8O17_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A8O17_00205	COG3870	Protein conserved in bacteria
A8O17_00210	COG1728	Protein conserved in bacteria
A8O17_00215	COG0470	DNA polymerase III
A8O17_00220	COG1774	PSP1 C-terminal conserved region
A8O17_00225	COG4467	Involved in initiation control of chromosome replication
A8O17_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A8O17_00235	COG2827	Endonuclease containing a URI domain
A8O17_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A8O17_00245	COG2002	toxin-antitoxin pair type II binding
A8O17_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8O17_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8O17_00255	COG0084	hydrolase, TatD family'
A8O17_00260	COG3583	domain protein
A8O17_00260	COG3584	3D domain protein
A8O17_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A8O17_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8O17_00280	COG4466	Protein conserved in bacteria
A8O17_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A8O17_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8O17_00300	COG0251	oxidation-reduction process
A8O17_00305	COG2088	sporulation resulting in formation of a cellular spore
A8O17_00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8O17_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8O17_00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A8O17_00330	COG0193	aminoacyl-tRNA hydrolase activity
A8O17_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8O17_00345	COG2002	toxin-antitoxin pair type II binding
A8O17_00350	COG2244	polysaccharide biosynthetic process
A8O17_00355	COG3956	TIGRFAM MazG family protein
A8O17_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A8O17_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A8O17_00380	COG1098	S1 RNA binding domain
A8O17_00395	COG2208	phosphoserine phosphatase activity
A8O17_00400	COG2304	oxidoreductase activity
A8O17_00405	COG0515	serine threonine protein kinase
A8O17_00410	COG0037	tRNA processing
A8O17_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8O17_00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A8O17_00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A8O17_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8O17_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8O17_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8O17_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
A8O17_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8O17_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8O17_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A8O17_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A8O17_00475	COG1396	sequence-specific DNA binding
A8O17_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8O17_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8O17_00570	COG4463	regulation of RNA biosynthetic process
A8O17_00575	COG3880	PFAM UvrB UvrC protein
A8O17_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A8O17_00585	COG0542	response to heat
A8O17_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A8O17_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A8O17_00600	COG4956	integral membrane protein (PIN domain superfamily)
A8O17_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A8O17_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A8O17_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8O17_00625	COG1045	serine acetyltransferase
A8O17_00630	COG0215	cysteine-tRNA ligase activity
A8O17_00635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A8O17_00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8O17_00645	COG3688	RNA-binding protein containing a PIN domain
A8O17_00650	COG1595	DNA-templated transcription, initiation
A8O17_00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8O17_00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8O17_00665	COG0250	Participates in transcription elongation, termination and antitermination
A8O17_00670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8O17_00675	COG0081	regulation of translation
A8O17_00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A8O17_00685	COG0222	ribosome binding
A8O17_00690	COG2813	Specifically methylates the guanine in position
A8O17_00695	COG0085	RNA polymerase activity
A8O17_00700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A8O17_00705	COG1358	cellular component organization or biogenesis
A8O17_00710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A8O17_00715	COG0049	tRNA binding
A8O17_00720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8O17_00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8O17_00730	COG0596	Alpha beta hydrolase
A8O17_00735	COG0051	transcription antitermination factor activity, RNA binding
A8O17_00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8O17_00745	COG0088	Forms part of the polypeptide exit tunnel
A8O17_00750	COG0089	rRNA binding
A8O17_00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8O17_00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A8O17_00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A8O17_00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A8O17_00775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8O17_00780	COG0255	Belongs to the universal ribosomal protein uL29 family
A8O17_00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8O17_00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A8O17_00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8O17_00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8O17_00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A8O17_00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8O17_00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8O17_00830	COG1841	ribosomal large subunit assembly
A8O17_00835	COG0200	Binds to the 23S rRNA
A8O17_00840	COG0201	protein transport
A8O17_00845	COG0563	adenylate kinase activity
A8O17_00850	COG0024	Methionine aminopeptidase
A8O17_00855	COG2163	COG2163 Ribosomal protein L14E L6E L27E
A8O17_00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8O17_00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A8O17_00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8O17_00875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A8O17_00880	COG0202	RNA polymerase activity
A8O17_00885	COG0203	ribosomal protein L17
A8O17_00890	COG1122	ATPase activity
A8O17_00895	COG1122	ATPase activity
A8O17_00900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8O17_00905	COG0101	tRNA pseudouridine synthase activity
A8O17_00910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A8O17_00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8O17_00920	COG2226	methyltransferase
A8O17_00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8O17_00935	COG0489	protein tyrosine kinase activity
A8O17_00945	COG2194	sulfuric ester hydrolase activity
A8O17_00950	COG0726	polysaccharide deacetylase
A8O17_01035	COG0659	secondary active sulfate transmembrane transporter activity
A8O17_01040	COG0385	Bile acid
A8O17_01045	COG2819	hydrolase of the alpha beta superfamily
A8O17_01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8O17_01065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8O17_01065	COG2207	Transcriptional regulator
A8O17_01070	COG3876	Protein conserved in bacteria
A8O17_01075	COG1472	Belongs to the glycosyl hydrolase 3 family
A8O17_01080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8O17_01085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_01085	COG1263	PTS System
A8O17_01090	COG1737	Transcriptional regulator
A8O17_01095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A8O17_01100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8O17_01105	COG1683	Conserved Protein
A8O17_01135	COG1595	DNA-templated transcription, initiation
A8O17_01140	COG5662	AntiSigma factor
A8O17_01145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A8O17_01150	COG4856	YbbR-like protein
A8O17_01155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8O17_01160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8O17_01165	COG0596	Alpha beta hydrolase
A8O17_01170	COG0745	RESPONSE REGULATOR receiver
A8O17_01175	COG0642	Histidine kinase
A8O17_01185	COG0515	serine threonine protein kinase
A8O17_01200	COG1113	amino acid transport
A8O17_01215	COG2602	Beta-lactamase
A8O17_01220	COG2124	cytochrome p450
A8O17_01230	COG0531	amino acid
A8O17_01235	COG0584	glycerophosphoryl diester phosphodiesterase
A8O17_01240	COG2271	Major facilitator Superfamily
A8O17_01250	COG0456	acetyltransferase
A8O17_01250	COG1846	Transcriptional regulator
A8O17_01255	COG2271	Major facilitator Superfamily
A8O17_01270	COG3409	Peptidoglycan-binding domain 1 protein
A8O17_01275	COG0697	spore germination
A8O17_01280	COG1917	Cupin 2, conserved barrel domain protein
A8O17_01280	COG2207	Transcriptional regulator
A8O17_01285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A8O17_01290	COG3591	Belongs to the peptidase S1B family
A8O17_01300	COG0596	Alpha beta hydrolase
A8O17_01305	COG1183	phosphatidylcholine synthase activity
A8O17_01310	COG0586	Pfam SNARE associated Golgi protein
A8O17_01315	COG0688	phosphatidylethanolamine metabolic process
A8O17_01325	COG2312	Erythromycin esterase
A8O17_01330	COG2207	Transcriptional regulator
A8O17_01340	COG1301	dicarboxylic acid transport
A8O17_01345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_01345	COG2190	(PTS) system
A8O17_01345	COG1263	PTS System
A8O17_01350	COG0363	glucosamine-6-phosphate deaminase activity
A8O17_01365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8O17_01370	COG0833	amino acid
A8O17_01375	COG2040	homocysteine
A8O17_01385	COG1115	amino acid carrier protein
A8O17_01390	COG2066	Belongs to the glutaminase family
A8O17_01395	COG4191	Histidine kinase
A8O17_01400	COG0784	Response regulator, receiver
A8O17_01405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8O17_01410	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_01415	COG2271	Major facilitator Superfamily
A8O17_01420	COG4948	Mandelate Racemase Muconate Lactonizing
A8O17_01425	COG2186	Transcriptional regulator
A8O17_01430	COG2721	sulfolactate sulfo-lyase activity
A8O17_01435	COG3173	Aminoglycoside phosphotransferase
A8O17_01445	COG0697	spore germination
A8O17_01450	COG0745	RESPONSE REGULATOR receiver
A8O17_01455	COG2205	protein histidine kinase activity
A8O17_01460	COG1131	(ABC) transporter
A8O17_01480	COG3773	Cell wall hydrolase
A8O17_01485	COG2304	oxidoreductase activity
A8O17_01495	COG3540	Alkaline phosphatase
A8O17_01500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8O17_01505	COG0805	protein transport
A8O17_01510	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A8O17_01515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8O17_01520	COG0477	Major facilitator Superfamily
A8O17_01525	COG1309	transcriptional regulator
A8O17_01530	COG0252	asparaginase activity
A8O17_01535	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A8O17_01540	COG1714	RDD family
A8O17_01545	COG3012	SEC-C Motif Domain Protein
A8O17_01545	COG1405	negative regulation of cell septum assembly
A8O17_01550	COG3290	protein histidine kinase activity
A8O17_01555	COG3279	Response regulator of the LytR AlgR family
A8O17_01560	COG4555	ABC transporter
A8O17_01565	COG1668	transmembrane transport
A8O17_01570	COG0667	Aldo Keto reductase
A8O17_01580	COG1595	DNA-templated transcription, initiation
A8O17_01585	COG1595	DNA-templated transcription, initiation
A8O17_01590	COG1876	peptidase activity
A8O17_01595	COG0457	Tetratricopeptide repeat
A8O17_01600	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_01605	COG0366	Alpha amylase catalytic
A8O17_01610	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8O17_01615	COG1121	(ABC) transporter
A8O17_01620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8O17_01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8O17_01630	COG2310	stress, protein
A8O17_01635	COG2310	stress, protein
A8O17_01640	COG2310	stress, protein
A8O17_01645	COG0861	Integral membrane protein TerC family
A8O17_01655	COG3853	Toxic anion resistance protein (TelA)
A8O17_01660	COG0477	Major facilitator Superfamily
A8O17_01665	COG2814	Major facilitator Superfamily
A8O17_01670	COG0640	Transcriptional regulator
A8O17_01675	COG4175	Glycine betaine
A8O17_01675	COG0517	IMP dehydrogenase activity
A8O17_01680	COG4176	ABC-type proline glycine betaine transport system permease component
A8O17_01685	COG2113	Glycine betaine
A8O17_01690	COG1473	amidohydrolase
A8O17_01695	COG1288	antiporter activity
A8O17_01710	COG0366	Alpha amylase catalytic
A8O17_01715	COG0039	L-malate dehydrogenase activity
A8O17_01720	COG1620	l-lactate permease
A8O17_01725	COG2814	Major facilitator Superfamily
A8O17_01730	COG1846	Transcriptional regulator
A8O17_01735	COG1280	lysine exporter protein (LysE YggA)
A8O17_01740	COG3403	YqcI/YcgG family
A8O17_01745	COG1113	amino acid transport
A8O17_01750	COG3665	Urea carboxylase-associated protein
A8O17_01755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A8O17_01760	COG1660	Displays ATPase and GTPase activities
A8O17_01765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8O17_01770	COG2226	methyltransferase
A8O17_01775	COG0583	DNA-binding transcription factor activity
A8O17_01780	COG3458	cephalosporin-C deacetylase activity
A8O17_01785	COG3541	Predicted nucleotidyltransferase
A8O17_01790	COG0506	proline dehydrogenase activity
A8O17_01795	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_01800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8O17_01805	COG2508	Transcriptional regulator
A8O17_01810	COG3689	TIGRFAM TIGR03943 family protein
A8O17_01815	COG0701	Predicted permease
A8O17_01820	COG2267	carboxylic ester hydrolase activity
A8O17_01825	COG0492	ferredoxin-NADP+ reductase activity
A8O17_01830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8O17_01830	COG1587	Uroporphyrinogen-III synthase
A8O17_01835	COG2146	nitrite reductase [NAD(P)H] activity
A8O17_01840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8O17_01845	COG0243	molybdopterin cofactor binding
A8O17_01850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8O17_01855	COG2223	nitrite transmembrane transporter activity
A8O17_01860	COG1469	GTP cyclohydrolase I activity
A8O17_01865	COG1376	ErfK ybiS ycfS ynhG family protein
A8O17_01875	COG0523	cobalamin synthesis protein
A8O17_01880	COG0765	amino acid transport
A8O17_01885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8O17_01895	COG1714	RDD family
A8O17_01905	COG2723	6-phospho-beta-galactosidase activity
A8O17_01915	COG3209	COG3209 Rhs family protein
A8O17_01920	COG0840	transmembrane signaling receptor activity
A8O17_01920	COG3290	protein histidine kinase activity
A8O17_01925	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A8O17_01930	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A8O17_01935	COG1733	regulation of RNA biosynthetic process
A8O17_01945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_01950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_01955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_01960	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A8O17_01965	COG2814	Major facilitator Superfamily
A8O17_01975	COG0697	spore germination
A8O17_01980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8O17_01990	COG2364	Membrane
A8O17_01995	COG1126	abc transporter atp-binding protein
A8O17_02000	COG0765	amino acid transport
A8O17_02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8O17_02010	COG0583	DNA-binding transcription factor activity
A8O17_02015	COG0163	prenyltransferase activity
A8O17_02020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8O17_02035	COG0596	Alpha beta hydrolase
A8O17_02040	COG3104	oligopeptide transport
A8O17_02045	COG5434	Belongs to the glycosyl hydrolase 28 family
A8O17_02055	COG0697	spore germination
A8O17_02065	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A8O17_02070	COG1136	(ABC) transporter
A8O17_02075	COG0577	efflux transmembrane transporter activity
A8O17_02080	COG0745	RESPONSE REGULATOR receiver
A8O17_02085	COG5002	protein histidine kinase activity
A8O17_02085	COG3850	Histidine kinase
A8O17_02090	COG0457	Tetratricopeptide repeat
A8O17_02105	COG0527	aspartate kinase activity
A8O17_02110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_02115	COG4605	iron ion homeostasis
A8O17_02120	COG4604	ABC transporter, ATP-binding protein
A8O17_02125	COG4607	ABC-type enterochelin transport system periplasmic component
A8O17_02130	COG2814	Major facilitator Superfamily
A8O17_02135	COG1309	transcriptional regulator
A8O17_02140	COG0778	Nitroreductase
A8O17_02145	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A8O17_02150	COG0640	Transcriptional regulator
A8O17_02155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8O17_02160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8O17_02165	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_02170	COG4975	Glucose uptake
A8O17_02175	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_02180	COG4549	nuclear export factor GLE1
A8O17_02185	COG2372	response to copper ion
A8O17_02185	COG1276	copper resistance
A8O17_02190	COG1349	DNA-binding transcription factor activity
A8O17_02200	COG2213	PTS system mannitol-specific
A8O17_02205	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8O17_02210	COG0246	Mannitol dehydrogenase
A8O17_02215	COG0473	3-isopropylmalate dehydrogenase activity
A8O17_02220	COG0681	Belongs to the peptidase S26 family
A8O17_02230	COG0412	Dienelactone hydrolase
A8O17_02235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8O17_02245	COG0561	phosphatase activity
A8O17_02250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A8O17_02255	COG1914	H( )-stimulated, divalent metal cation uptake system
A8O17_02260	COG4336	lyase activity
A8O17_02265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8O17_02270	COG1984	allophanate hydrolase subunit 2
A8O17_02275	COG1414	Transcriptional regulator
A8O17_02280	COG2755	lipolytic protein G-D-S-L family
A8O17_02290	COG2329	Antibiotic biosynthesis monooxygenase
A8O17_02295	COG0768	penicillin binding
A8O17_02300	COG4989	oxidoreductase activity
A8O17_02305	COG3711	transcriptional antiterminator
A8O17_02310	COG0318	PFAM AMP-dependent synthetase and ligase
A8O17_02315	COG2226	methyltransferase
A8O17_02320	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_02325	COG1917	Cupin 2, conserved barrel domain protein
A8O17_02330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8O17_02335	COG3871	stress protein (general stress protein 26)
A8O17_02345	COG2814	Major facilitator Superfamily
A8O17_02350	COG1522	sequence-specific DNA binding
A8O17_02355	COG0551	DNA topoisomerase type I activity
A8O17_02355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8O17_02360	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A8O17_02365	COG3706	GGDEF domain
A8O17_02370	COG5298	Protein conserved in bacteria
A8O17_02375	COG1215	transferase activity, transferring glycosyl groups
A8O17_02385	COG0531	amino acid
A8O17_02390	COG0494	nUDIX hydrolase
A8O17_02395	COG0028	Belongs to the TPP enzyme family
A8O17_02410	COG1914	H( )-stimulated, divalent metal cation uptake system
A8O17_02415	COG2261	transglycosylase associated protein
A8O17_02420	COG4876	unkown
A8O17_02425	COG2217	Heavy metal translocating P-type atpase
A8O17_02430	COG3729	General stress protein
A8O17_02435	COG0662	Cupin 2, conserved barrel domain protein
A8O17_02440	COG2329	Antibiotic biosynthesis monooxygenase
A8O17_02445	COG3546	catalase activity
A8O17_02450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8O17_02455	COG3290	protein histidine kinase activity
A8O17_02460	COG4565	transcriptional regulatory protein
A8O17_02465	COG1301	dicarboxylic acid transport
A8O17_02470	COG0628	permease
A8O17_02480	COG1131	(ABC) transporter
A8O17_02485	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8O17_02495	COG1960	acyl-CoA dehydrogenase activity
A8O17_02510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8O17_02515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8O17_02520	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8O17_02525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8O17_02530	COG0513	Belongs to the DEAD box helicase family
A8O17_02535	COG3402	PFAM membrane-flanked domain
A8O17_02540	COG3428	Bacterial PH domain
A8O17_02545	COG0705	Rhomboid family
A8O17_02550	COG0736	holo-[acyl-carrier-protein] synthase activity
A8O17_02555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A8O17_02560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8O17_02565	COG0864	Transcriptional regulator
A8O17_02570	COG2337	Toxic component of a toxin-antitoxin (TA) module
A8O17_02575	COG1366	Belongs to the anti-sigma-factor antagonist family
A8O17_02580	COG1366	Belongs to the anti-sigma-factor antagonist family
A8O17_02585	COG2172	sigma factor antagonist activity
A8O17_02590	COG2208	phosphoserine phosphatase activity
A8O17_02595	COG1366	Belongs to the anti-sigma-factor antagonist family
A8O17_02600	COG2172	sigma factor antagonist activity
A8O17_02605	COG1191	sigma factor activity
A8O17_02610	COG2208	phosphoserine phosphatase activity
A8O17_02625	COG1673	EVE domain
A8O17_02630	COG1846	Transcriptional regulator
A8O17_02635	COG2183	response to ionizing radiation
A8O17_02645	COG3091	SprT-like family
A8O17_02685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8O17_02690	COG1522	sequence-specific DNA binding
A8O17_02695	COG1522	sequence-specific DNA binding
A8O17_02700	COG1335	isochorismatase
A8O17_02705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A8O17_02710	COG2814	Major facilitator Superfamily
A8O17_02730	COG0693	protein deglycase activity
A8O17_02735	COG1278	Cold shock
A8O17_02740	COG1329	Transcriptional regulator
A8O17_02745	COG0697	spore germination
A8O17_02750	COG2207	Transcriptional regulator
A8O17_02750	COG1917	Cupin 2, conserved barrel domain protein
A8O17_02755	COG0697	spore germination
A8O17_02760	COG3708	Transcriptional regulator
A8O17_02760	COG2207	Transcriptional regulator
A8O17_02765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8O17_02770	COG0477	Major facilitator Superfamily
A8O17_02780	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A8O17_02790	COG0697	spore germination
A8O17_02795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8O17_02800	COG2030	dehydratase
A8O17_02805	COG3545	Serine hydrolase
A8O17_02810	COG1733	regulation of RNA biosynthetic process
A8O17_02815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8O17_02820	COG1733	regulation of RNA biosynthetic process
A8O17_02825	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8O17_02830	COG2814	Major facilitator Superfamily
A8O17_02835	COG1309	transcriptional regulator
A8O17_02845	COG0640	Transcriptional regulator
A8O17_02850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A8O17_02860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8O17_02865	COG0697	spore germination
A8O17_02870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8O17_02875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8O17_02880	COG0640	Transcriptional regulator
A8O17_02885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8O17_02895	COG4585	Histidine kinase
A8O17_02900	COG2197	response regulator
A8O17_02905	COG2409	Drug exporters of the RND superfamily
A8O17_02910	COG0596	Alpha beta hydrolase
A8O17_02915	COG1811	Na channel or pump
A8O17_02920	COG0789	Transcriptional regulator
A8O17_02920	COG4978	Transcriptional regulator
A8O17_02925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8O17_02930	COG0778	Nitroreductase
A8O17_02935	COG0346	lactoylglutathione lyase activity
A8O17_02940	COG2259	Doxx family
A8O17_02945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8O17_02965	COG2323	membrane
A8O17_02970	COG2323	membrane
A8O17_02975	COG0071	Belongs to the small heat shock protein (HSP20) family
A8O17_02990	COG1309	transcriptional regulator
A8O17_03000	COG0456	acetyltransferase
A8O17_03010	COG1113	amino acid transport
A8O17_03015	COG2318	DinB family
A8O17_03020	COG1846	Transcriptional regulator
A8O17_03025	COG2409	Drug exporters of the RND superfamily
A8O17_03025	COG1033	growth of symbiont in host cell
A8O17_03030	COG0778	Nitroreductase
A8O17_03035	COG1846	Transcriptional regulator
A8O17_03040	COG2814	Major facilitator Superfamily
A8O17_03045	COG0730	response to heat
A8O17_03050	COG1802	Transcriptional regulator
A8O17_03055	COG1388	LysM domain
A8O17_03055	COG3858	chitin binding
A8O17_03060	COG1819	glycosyl
A8O17_03070	COG1785	Belongs to the alkaline phosphatase family
A8O17_03075	COG5646	InterPro IPR014922
A8O17_03085	COG0454	-acetyltransferase
A8O17_03090	COG1078	dGTPase activity
A8O17_03095	COG1388	LysM domain
A8O17_03100	COG2814	Major facilitator Superfamily
A8O17_03105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8O17_03110	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8O17_03115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8O17_03120	COG2723	6-phospho-beta-galactosidase activity
A8O17_03125	COG2188	Transcriptional regulator
A8O17_03130	COG1940	carbohydrate kinase activity
A8O17_03135	COG1482	cell wall glycoprotein biosynthetic process
A8O17_03140	COG4124	Belongs to the glycosyl hydrolase 26 family
A8O17_03185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A8O17_03190	COG0802	atpase or kinase
A8O17_03195	COG1214	PFAM Peptidase M22, glycoprotease
A8O17_03200	COG0456	acetyltransferase
A8O17_03205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8O17_03210	COG0488	(ABC) transporter
A8O17_03215	COG0315	cyclic pyranopterin monophosphate synthase activity
A8O17_03220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A8O17_03225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8O17_03230	COG0805	protein transport
A8O17_03240	COG1266	CAAX protease self-immunity
A8O17_03245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8O17_03250	COG0459	protein refolding
A8O17_03265	COG0457	Tetratricopeptide repeat
A8O17_03270	COG1063	alcohol dehydrogenase
A8O17_03275	COG2211	Major facilitator Superfamily
A8O17_03280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8O17_03285	COG1842	Phage shock protein A
A8O17_03290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8O17_03295	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A8O17_03300	COG4260	virion core protein, lumpy skin disease virus
A8O17_03310	COG2814	Major facilitator Superfamily
A8O17_03315	COG1063	alcohol dehydrogenase
A8O17_03320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8O17_03325	COG0823	Involved in the tonB-independent uptake of proteins
A8O17_03340	COG2267	carboxylic ester hydrolase activity
A8O17_03350	COG2132	Multicopper oxidase
A8O17_03355	COG1113	amino acid transport
A8O17_03365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8O17_03370	COG0714	Associated with various cellular activities
A8O17_03375	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A8O17_03380	COG1305	Transglutaminase-like
A8O17_03385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8O17_03385	COG0519	Catalyzes the synthesis of GMP from XMP
A8O17_03390	COG2252	PERMEase
A8O17_03395	COG3064	Membrane
A8O17_03405	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A8O17_03415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8O17_03420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8O17_03425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8O17_03430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A8O17_03435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8O17_03440	COG0047	phosphoribosylformylglycinamidine synthase activity
A8O17_03445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8O17_03450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A8O17_03455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A8O17_03460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A8O17_03465	COG0138	bifunctional purine biosynthesis protein purh
A8O17_03470	COG0151	Belongs to the GarS family
A8O17_03475	COG1522	sequence-specific DNA binding
A8O17_03480	COG0531	amino acid
A8O17_03490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A8O17_03495	COG1470	cell adhesion involved in biofilm formation
A8O17_03500	COG4496	protein, YerC YecD
A8O17_03505	COG0069	glutamate synthase activity
A8O17_03515	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A8O17_03520	COG0210	DNA helicase
A8O17_03525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8O17_03530	COG4851	CamS sex pheromone cAM373 precursor
A8O17_03535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8O17_03540	COG1285	pathogenesis
A8O17_03545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8O17_03550	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8O17_03555	COG0154	amidase activity
A8O17_03560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8O17_03565	COG1309	transcriptional regulator
A8O17_03570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8O17_03575	COG1597	lipid kinase activity
A8O17_03580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8O17_03585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A8O17_03590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A8O17_03595	COG1002	Type II restriction enzyme, methylase subunits
A8O17_03600	COG1061	Type III restriction enzyme res subunit
A8O17_03605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A8O17_03625	COG5444	nuclease activity
A8O17_03630	COG3391	amine dehydrogenase activity
A8O17_03635	COG0457	Tetratricopeptide repeat
A8O17_03645	COG0217	transcriptional regulatory protein
A8O17_03655	COG1309	transcriptional regulator
A8O17_03660	COG3631	Ketosteroid isomerase-related protein
A8O17_03665	COG0702	epimerase
A8O17_03680	COG3546	catalase activity
A8O17_03685	COG0454	-acetyltransferase
A8O17_03695	COG5578	integral membrane protein
A8O17_03700	COG2972	Histidine kinase
A8O17_03705	COG4753	response regulator
A8O17_03705	COG2207	Transcriptional regulator
A8O17_03710	COG1653	transport
A8O17_03715	COG1175	transmembrane transport
A8O17_03720	COG0395	ABC-type sugar transport system, permease component
A8O17_03725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8O17_03730	COG2207	Transcriptional regulator
A8O17_03735	COG2755	lipolytic protein G-D-S-L family
A8O17_03745	COG5578	integral membrane protein
A8O17_03750	COG3401	FG-GAP repeat protein
A8O17_03755	COG3401	FG-GAP repeat protein
A8O17_03760	COG2755	lipolytic protein G-D-S-L family
A8O17_03765	COG1874	Beta-galactosidase
A8O17_03775	COG1653	transport
A8O17_03780	COG4209	transmembrane transport
A8O17_03785	COG0395	ABC-type sugar transport system, permease component
A8O17_03790	COG1486	melibiose metabolic process
A8O17_03795	COG2323	membrane
A8O17_03800	COG2329	Antibiotic biosynthesis monooxygenase
A8O17_03805	COG0346	lactoylglutathione lyase activity
A8O17_03820	COG5583	Uncharacterized small protein (DUF2292)
A8O17_03825	COG0670	Belongs to the BI1 family
A8O17_03830	COG0697	spore germination
A8O17_03835	COG1846	Transcriptional regulator
A8O17_03840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8O17_03850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A8O17_03850	COG2124	cytochrome p450
A8O17_03855	COG1368	sulfuric ester hydrolase activity
A8O17_03860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8O17_03865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8O17_03870	COG1442	glycosyl transferase family 8
A8O17_03875	COG1216	Glycosyl transferase, family 2
A8O17_03880	COG1442	glycosyl transferase family 8
A8O17_03885	COG2223	nitrite transmembrane transporter activity
A8O17_03890	COG1011	Hydrolase
A8O17_03895	COG0531	amino acid
A8O17_03900	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_03905	COG0840	transmembrane signaling receptor activity
A8O17_03910	COG0488	(ABC) transporter
A8O17_03920	COG0789	Transcriptional regulator
A8O17_03925	COG2814	Major facilitator Superfamily
A8O17_03940	COG0488	(ABC) transporter
A8O17_03945	COG0513	Belongs to the DEAD box helicase family
A8O17_03950	COG0456	acetyltransferase
A8O17_03955	COG2130	NADP-dependent
A8O17_03970	COG2211	Major facilitator Superfamily
A8O17_03975	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A8O17_03980	COG1120	ATPase activity
A8O17_03985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_03990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_03995	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A8O17_04010	COG3866	Pectate lyase
A8O17_04015	COG0471	metal ion transport
A8O17_04020	COG3290	protein histidine kinase activity
A8O17_04025	COG4565	transcriptional regulatory protein
A8O17_04030	COG3181	Tripartite tricarboxylate transporter family receptor
A8O17_04040	COG2851	Citrate transporter
A8O17_04045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8O17_04050	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A8O17_04055	COG1254	Belongs to the acylphosphatase family
A8O17_04060	COG2258	MOSC domain
A8O17_04080	COG0024	Methionine aminopeptidase
A8O17_04085	COG1263	PTS System
A8O17_04085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_04090	COG1368	sulfuric ester hydrolase activity
A8O17_04100	COG1115	amino acid carrier protein
A8O17_04105	COG0531	amino acid
A8O17_04120	COG0697	spore germination
A8O17_04125	COG1263	PTS System
A8O17_04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_04130	COG0366	Alpha amylase catalytic
A8O17_04135	COG2188	Transcriptional regulator
A8O17_04140	COG0778	Nitroreductase
A8O17_04145	COG0737	Belongs to the 5'-nucleotidase family
A8O17_04150	COG0693	protein deglycase activity
A8O17_04155	COG2814	Major facilitator Superfamily
A8O17_04160	COG4840	Belongs to the UPF0435 family
A8O17_04165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8O17_04170	COG4980	gas vesicle protein
A8O17_04175	COG1295	ribonuclease BN
A8O17_04185	COG0477	Major facilitator Superfamily
A8O17_04195	COG0387	Pfam Sodium calcium exchanger
A8O17_04205	COG0668	transmembrane transport
A8O17_04210	COG0535	radical SAM domain protein
A8O17_04220	COG0726	polysaccharide deacetylase
A8O17_04225	COG2084	Dehydrogenase
A8O17_04230	COG0598	Magnesium transport protein CorA
A8O17_04235	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A8O17_04240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8O17_04250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8O17_04255	COG4637	Psort location Cytoplasmic, score
A8O17_04265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8O17_04270	COG0022	dehydrogenase e1 component
A8O17_04275	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8O17_04280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8O17_04285	COG3284	Transcriptional regulator
A8O17_04295	COG1742	UPF0060 membrane protein
A8O17_04320	COG4842	Belongs to the WXG100 family
A8O17_04325	COG1486	melibiose metabolic process
A8O17_04330	COG1737	Transcriptional regulator
A8O17_04335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_04335	COG1263	PTS System
A8O17_04340	COG1132	(ABC) transporter
A8O17_04345	COG1132	(ABC) transporter
A8O17_04350	COG2259	Doxx family
A8O17_04355	COG2514	catechol 2,3-dioxygenase activity
A8O17_04360	COG4977	sequence-specific DNA binding
A8O17_04360	COG1917	Cupin 2, conserved barrel domain protein
A8O17_04365	COG2814	Major facilitator Superfamily
A8O17_04370	COG1082	Xylose isomerase domain protein TIM barrel
A8O17_04375	COG0673	inositol 2-dehydrogenase activity
A8O17_04380	COG4585	Histidine kinase
A8O17_04385	COG2197	response regulator
A8O17_04390	COG1131	(ABC) transporter
A8O17_04395	COG0842	Transport permease protein
A8O17_04395	COG1511	domain protein
A8O17_04400	COG0842	Transport permease protein
A8O17_04405	COG1695	Transcriptional regulator
A8O17_04410	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A8O17_04415	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
A8O17_04420	COG1309	transcriptional regulator
A8O17_04425	COG2814	Major facilitator Superfamily
A8O17_04430	COG2318	DinB family
A8O17_04435	COG2814	Major facilitator Superfamily
A8O17_04440	COG1846	Transcriptional regulator
A8O17_04445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A8O17_04445	COG0392	lysyltransferase activity
A8O17_04450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8O17_04455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_04460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_04465	COG0384	phenazine biosynthesis protein PhzF
A8O17_04470	COG0778	Nitroreductase
A8O17_04485	COG1090	epimerase
A8O17_04490	COG2137	regulation of response to DNA damage stimulus
A8O17_04505	COG2814	Major facilitator Superfamily
A8O17_04520	COG3103	Sh3 type 3 domain protein
A8O17_04525	COG5658	integral membrane protein
A8O17_04530	COG0596	Alpha beta hydrolase
A8O17_04535	COG0463	Glycosyl transferase, family 2
A8O17_04540	COG4485	Bacterial membrane protein, YfhO
A8O17_04545	COG1988	membrane-bound metal-dependent
A8O17_04550	COG1194	a g-specific adenine glycosylase
A8O17_04560	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_04575	COG3557	Belongs to the UPF0374 family
A8O17_04580	COG1132	(ABC) transporter
A8O17_04585	COG4129	membrane
A8O17_04590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8O17_04595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A8O17_04600	COG0735	belongs to the Fur family
A8O17_04715	COG4326	sporulation control protein
A8O17_04725	COG5577	PFAM Coat F domain
A8O17_04730	COG3340	Belongs to the peptidase S51 family
A8O17_04735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A8O17_04740	COG0277	FAD linked oxidase domain protein
A8O17_04750	COG0753	catalase activity
A8O17_04755	COG1116	anion transmembrane transporter activity
A8O17_04760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8O17_04765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8O17_04770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8O17_04780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8O17_04790	COG1476	TRANSCRIPTIONal
A8O17_04800	COG3382	B3 4 domain protein
A8O17_04805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A8O17_04815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A8O17_04820	COG0789	Transcriptional regulator
A8O17_04825	COG1664	Polymer-forming cytoskeletal
A8O17_04830	COG1664	Polymer-forming cytoskeletal
A8O17_04835	COG2766	serine protein kinase
A8O17_04840	COG2718	Belongs to the UPF0229 family
A8O17_04850	COG1846	Transcriptional regulator
A8O17_04855	COG1566	PFAM secretion protein HlyD family protein
A8O17_04860	COG2814	Major facilitator Superfamily
A8O17_04865	COG0655	NAD(P)H dehydrogenase (quinone) activity
A8O17_04880	COG1725	Transcriptional regulator
A8O17_04885	COG1131	(ABC) transporter
A8O17_04890	COG1131	(ABC) transporter
A8O17_04895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8O17_04900	COG1278	Cold shock
A8O17_04910	COG1464	Belongs to the NlpA lipoprotein family
A8O17_04915	COG3706	GGDEF domain
A8O17_04920	COG1823	symporter activity
A8O17_04940	COG5577	PFAM Coat F domain
A8O17_04945	COG4085	toxin activity
A8O17_04945	COG1525	nuclease
A8O17_04945	COG0737	Belongs to the 5'-nucleotidase family
A8O17_04950	COG3764	Sortase (surface protein transpeptidase)
A8O17_04955	COG0564	pseudouridine synthase activity
A8O17_04965	COG0517	IMP dehydrogenase activity
A8O17_04970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8O17_04975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8O17_04975	COG3153	acetyltransferase
A8O17_04980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8O17_04985	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A8O17_04990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8O17_04995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8O17_05000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8O17_05005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8O17_05010	COG2203	Gaf domain
A8O17_05010	COG4585	Histidine kinase
A8O17_05015	COG2197	response regulator
A8O17_05020	COG0431	NADPH-dependent FMN reductase
A8O17_05035	COG1388	LysM domain
A8O17_05035	COG0791	NLP P60 protein
A8O17_05040	COG1959	2 iron, 2 sulfur cluster binding
A8O17_05045	COG0668	transmembrane transport
A8O17_05050	COG2719	SpoVR family
A8O17_05055	COG1785	Belongs to the alkaline phosphatase family
A8O17_05060	COG1388	LysM domain
A8O17_05060	COG0791	NLP P60 protein
A8O17_05065	COG0583	DNA-binding transcription factor activity
A8O17_05070	COG0372	Belongs to the citrate synthase family
A8O17_05075	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_05080	COG0531	amino acid
A8O17_05085	COG0733	neurotransmitter:sodium symporter activity
A8O17_05090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8O17_05095	COG0456	acetyltransferase
A8O17_05110	COG1595	DNA-templated transcription, initiation
A8O17_05115	COG0667	Aldo Keto reductase
A8O17_05120	COG0204	Acyl-transferase
A8O17_05125	COG1253	flavin adenine dinucleotide binding
A8O17_05130	COG0789	Transcriptional regulator
A8O17_05135	COG0436	Aminotransferase
A8O17_05140	COG1253	flavin adenine dinucleotide binding
A8O17_05145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8O17_05150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8O17_05155	COG0584	glycerophosphoryl diester phosphodiesterase
A8O17_05165	COG0668	transmembrane transport
A8O17_05170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A8O17_05175	COG0726	polysaccharide deacetylase
A8O17_05180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8O17_05185	COG1757	Na H antiporter
A8O17_05190	COG0589	response to stress
A8O17_05200	COG1132	(ABC) transporter
A8O17_05205	COG1132	(ABC) transporter
A8O17_05210	COG0702	epimerase
A8O17_05225	COG0189	ligase activity
A8O17_05230	COG0189	ligase activity
A8O17_05235	COG4399	Belongs to the UPF0754 family
A8O17_05240	COG3679	Belongs to the UPF0342 family
A8O17_05245	COG4335	DNA alkylation repair
A8O17_05250	COG0561	phosphatase activity
A8O17_05255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8O17_05260	COG0475	glutathione-regulated potassium exporter activity
A8O17_05265	COG0490	domain, Protein
A8O17_05275	COG1024	Enoyl-CoA hydratase
A8O17_05285	COG4152	abc transporter atp-binding protein
A8O17_05290	COG1668	transmembrane transport
A8O17_05295	COG0420	3'-5' exonuclease activity
A8O17_05300	COG4717	serine-type aminopeptidase activity
A8O17_05305	COG3481	metal-dependent phosphohydrolase, HD sub domain
A8O17_05315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8O17_05335	COG1846	Transcriptional regulator
A8O17_05340	COG4980	gas vesicle protein
A8O17_05355	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A8O17_05360	COG0537	adenosine 5'-monophosphoramidase activity
A8O17_05365	COG1131	(ABC) transporter
A8O17_05370	COG4473	ABC transporter
A8O17_05380	COG1473	amidohydrolase
A8O17_05385	COG3069	C4-dicarboxylate transmembrane transporter activity
A8O17_05395	COG2329	Antibiotic biosynthesis monooxygenase
A8O17_05400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8O17_05405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8O17_05420	COG1309	transcriptional regulator
A8O17_05425	COG1511	domain protein
A8O17_05430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8O17_05435	COG4377	Putative membrane peptidase family (DUF2324)
A8O17_05445	COG1363	Peptidase, m42
A8O17_05450	COG4405	Protein conserved in bacteria
A8O17_05455	COG1301	dicarboxylic acid transport
A8O17_05465	COG1234	tRNA 3'-trailer cleavage
A8O17_05470	COG0095	Lipoate-protein ligase
A8O17_05475	COG0702	epimerase
A8O17_05480	COG0318	PFAM AMP-dependent synthetase and ligase
A8O17_05490	COG0501	Belongs to the peptidase M48B family
A8O17_05495	COG1404	Belongs to the peptidase S8 family
A8O17_05500	COG0456	acetyltransferase
A8O17_05505	COG0604	alcohol dehydrogenase
A8O17_05510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A8O17_05515	COG0406	alpha-ribazole phosphatase activity
A8O17_05520	COG0183	Belongs to the thiolase family
A8O17_05525	COG0318	PFAM AMP-dependent synthetase and ligase
A8O17_05530	COG1268	BioY protein
A8O17_05535	COG0840	transmembrane signaling receptor activity
A8O17_05540	COG0723	plastoquinol--plastocyanin reductase activity
A8O17_05540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8O17_05545	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_05555	COG4903	ComK protein
A8O17_05560	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_05570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8O17_05585	COG0398	Pfam SNARE associated Golgi protein
A8O17_05590	COG0681	Belongs to the peptidase S26 family
A8O17_05595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8O17_05600	COG1846	Transcriptional regulator
A8O17_05605	COG0738	Major facilitator superfamily
A8O17_05610	COG0673	inositol 2-dehydrogenase activity
A8O17_05615	COG0561	phosphatase activity
A8O17_05620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8O17_05625	COG1609	Transcriptional regulator
A8O17_05630	COG3180	Ammonia monooxygenase
A8O17_05635	COG0477	Major facilitator Superfamily
A8O17_05635	COG2814	Major facilitator Superfamily
A8O17_05640	COG4533	DNA binding
A8O17_05650	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A8O17_05655	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A8O17_05660	COG1074	ATP-dependent DNA helicase activity
A8O17_05665	COG0420	3'-5' exonuclease activity
A8O17_05670	COG0419	ATPase involved in DNA repair
A8O17_05675	COG1403	HNH endonuclease
A8O17_05720	COG5337	Spore coat protein CotH
A8O17_05725	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8O17_05735	COG1404	Belongs to the peptidase S8 family
A8O17_05745	COG0367	asparagine synthase
A8O17_05750	COG2318	DinB family
A8O17_05755	COG1562	ergosterol biosynthetic process
A8O17_05760	COG0534	Mate efflux family protein
A8O17_05765	COG1917	Cupin 2, conserved barrel domain protein
A8O17_05765	COG2207	Transcriptional regulator
A8O17_05770	COG1609	Transcriptional regulator
A8O17_05775	COG0673	inositol 2-dehydrogenase activity
A8O17_05780	COG2318	DinB family
A8O17_05785	COG1279	arginine transmembrane transporter activity
A8O17_05790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8O17_05795	COG1357	PFAM Pentapeptide repeats (8 copies)
A8O17_05800	COG2267	carboxylic ester hydrolase activity
A8O17_05805	COG0529	Catalyzes the synthesis of activated sulfate
A8O17_05810	COG2046	Belongs to the sulfate adenylyltransferase family
A8O17_05815	COG0175	sulfate reduction
A8O17_05820	COG2045	Belongs to the ComB family
A8O17_05825	COG1809	phosphosulfolactate synthase activity
A8O17_05830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8O17_05835	COG4948	Mandelate Racemase Muconate Lactonizing
A8O17_05840	COG2814	Major facilitator Superfamily
A8O17_05845	COG0454	-acetyltransferase
A8O17_05850	COG2153	protein acetylation
A8O17_05855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A8O17_05855	COG0646	methionine synthase
A8O17_05860	COG1666	GTP binding
A8O17_05865	COG2996	Protein conserved in bacteria
A8O17_05885	COG1695	Transcriptional regulator
A8O17_05900	COG3227	Zinc metalloprotease (Elastase)
A8O17_05905	COG1307	EDD domain protein, DegV family
A8O17_05910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8O17_05930	COG0561	phosphatase activity
A8O17_05935	COG1073	alpha beta
A8O17_05940	COG2151	metal-sulfur cluster biosynthetic enzyme
A8O17_05950	COG0277	FAD linked oxidase domain protein
A8O17_05955	COG2271	Major facilitator Superfamily
A8O17_05960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8O17_05975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8O17_05980	COG0505	Belongs to the CarA family
A8O17_05985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8O17_05990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A8O17_06005	COG2267	carboxylic ester hydrolase activity
A8O17_06015	COG1744	ABC transporter substrate-binding protein PnrA-like
A8O17_06030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8O17_06035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8O17_06040	COG5504	Zn-dependent protease
A8O17_06045	COG0444	Belongs to the ABC transporter superfamily
A8O17_06050	COG4608	Belongs to the ABC transporter superfamily
A8O17_06060	COG0601	transmembrane transport
A8O17_06065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8O17_06075	COG0180	Tryptophanyl-tRNA synthetase
A8O17_06080	COG4166	transmembrane transport
A8O17_06085	COG0601	transmembrane transport
A8O17_06090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8O17_06095	COG0444	Belongs to the ABC transporter superfamily
A8O17_06100	COG4608	Belongs to the ABC transporter superfamily
A8O17_06105	COG2814	Major facilitator Superfamily
A8O17_06110	COG0456	acetyltransferase
A8O17_06115	COG1393	Belongs to the ArsC family
A8O17_06120	COG0861	Integral membrane protein TerC family
A8O17_06125	COG4862	establishment of competence for transformation
A8O17_06130	COG4469	Competence protein
A8O17_06135	COG1164	Oligoendopeptidase f
A8O17_06155	COG2346	COG2346, Truncated hemoglobins
A8O17_06160	COG0741	lytic transglycosylase activity
A8O17_06165	COG4116	CYTH
A8O17_06175	COG2357	RelA SpoT domain protein
A8O17_06180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8O17_06185	COG0564	pseudouridine synthase activity
A8O17_06190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8O17_06195	COG0569	domain protein
A8O17_06195	COG0475	glutathione-regulated potassium exporter activity
A8O17_06200	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A8O17_06205	COG0352	thiamine-phosphate diphosphorylase activity
A8O17_06210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8O17_06215	COG2104	thiamine diphosphate biosynthetic process
A8O17_06220	COG2022	thiamine diphosphate biosynthetic process
A8O17_06225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8O17_06230	COG0351	phosphomethylpyrimidine kinase
A8O17_06235	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8O17_06295	COG0210	DNA helicase
A8O17_06305	COG2153	protein acetylation
A8O17_06310	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A8O17_06315	COG2382	esterase
A8O17_06320	COG0626	cystathionine gamma-synthase activity
A8O17_06325	COG0626	cystathionine gamma-synthase activity
A8O17_06330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8O17_06335	COG5505	Protein of unknown function (DUF819)
A8O17_06370	COG3677	Transposase
A8O17_06385	COG5484	DNA packaging
A8O17_06390	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A8O17_06395	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_06405	COG3711	transcriptional antiterminator
A8O17_06405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8O17_06410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8O17_06410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8O17_06410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8O17_06415	COG1482	cell wall glycoprotein biosynthetic process
A8O17_06425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8O17_06435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8O17_06450	COG0109	protoheme IX farnesyltransferase activity
A8O17_06460	COG0726	polysaccharide deacetylase
A8O17_06480	COG5504	Zn-dependent protease
A8O17_06485	COG2205	protein histidine kinase activity
A8O17_06495	COG3383	formate dehydrogenase (NAD+) activity
A8O17_06500	COG2427	Protein of unknown function (DUF1641)
A8O17_06510	COG1051	belongs to the nudix hydrolase family
A8O17_06520	COG2124	cytochrome p450
A8O17_06525	COG1819	glycosyl
A8O17_06535	COG1587	Uroporphyrinogen-III synthase
A8O17_06540	COG0390	transport system, permease component
A8O17_06545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8O17_06550	COG0697	spore germination
A8O17_06555	COG4297	protein containing double-stranded beta helix domain
A8O17_06565	COG1252	NADH dehydrogenase
A8O17_06570	COG1904	glucuronate isomerase
A8O17_06575	COG2211	Major facilitator Superfamily
A8O17_06580	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8O17_06585	COG1063	alcohol dehydrogenase
A8O17_06590	COG1312	Catalyzes the dehydration of D-mannonate
A8O17_06595	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_06600	COG2271	Major facilitator Superfamily
A8O17_06605	COG1609	Transcriptional regulator
A8O17_06610	COG0246	Mannitol dehydrogenase
A8O17_06615	COG2721	sulfolactate sulfo-lyase activity
A8O17_06620	COG0730	response to heat
A8O17_06640	COG0306	phosphate transporter
A8O17_06645	COG1392	Phosphate transport regulator
A8O17_06650	COG0531	amino acid
A8O17_06655	COG0346	lactoylglutathione lyase activity
A8O17_06660	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8O17_06665	COG0463	Glycosyl transferase, family 2
A8O17_06675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8O17_06680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8O17_06685	COG2362	D-Aminopeptidase
A8O17_06690	COG0601	transmembrane transport
A8O17_06695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8O17_06700	COG0444	Belongs to the ABC transporter superfamily
A8O17_06705	COG4166	transmembrane transport
A8O17_06710	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8O17_06715	COG4948	Mandelate Racemase Muconate Lactonizing
A8O17_06720	COG0791	NLP P60 protein
A8O17_06725	COG4608	Belongs to the ABC transporter superfamily
A8O17_06730	COG2706	6-phosphogluconolactonase activity
A8O17_06735	COG1834	amidinotransferase
A8O17_06740	COG1607	acyl-coa hydrolase
A8O17_06745	COG1017	nitric oxide dioxygenase activity
A8O17_06745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8O17_06755	COG2323	membrane
A8O17_06760	COG2318	DinB family
A8O17_06765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8O17_06770	COG2076	Multidrug Resistance protein
A8O17_06775	COG2076	Multidrug Resistance protein
A8O17_06780	COG0788	formyltetrahydrofolate deformylase activity
A8O17_06785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8O17_06790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A8O17_06795	COG1764	response to oxidative stress
A8O17_06800	COG1846	Transcriptional regulator
A8O17_06805	COG1764	response to oxidative stress
A8O17_06815	COG0590	tRNA wobble adenosine to inosine editing
A8O17_06820	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8O17_06825	COG1404	Belongs to the peptidase S8 family
A8O17_06830	COG1366	Belongs to the anti-sigma-factor antagonist family
A8O17_06835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8O17_06840	COG1122	ATPase activity
A8O17_06845	COG4721	ABC-type cobalt transport system, permease component
A8O17_06855	COG0745	RESPONSE REGULATOR receiver
A8O17_06860	COG3850	Histidine kinase
A8O17_06860	COG5002	protein histidine kinase activity
A8O17_06865	COG3212	peptidase
A8O17_06870	COG3212	peptidase
A8O17_06890	COG2239	Acts as a magnesium transporter
A8O17_06895	COG0789	Transcriptional regulator
A8O17_06910	COG1846	Transcriptional regulator
A8O17_06915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8O17_06920	COG0726	polysaccharide deacetylase
A8O17_06925	COG1408	metallophosphoesterase
A8O17_06935	COG0463	Glycosyl transferase, family 2
A8O17_06940	COG1793	dna ligase
A8O17_06940	COG3285	dna ligase
A8O17_06945	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A8O17_06950	COG5001	Diguanylate cyclase
A8O17_06950	COG3300	MHYT domain
A8O17_06955	COG0586	Pfam SNARE associated Golgi protein
A8O17_06960	COG0861	Integral membrane protein TerC family
A8O17_06965	COG1191	sigma factor activity
A8O17_06985	COG0501	Belongs to the peptidase M48B family
A8O17_06990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A8O17_07005	COG3594	Acyltransferase
A8O17_07010	COG5002	protein histidine kinase activity
A8O17_07015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8O17_07025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A8O17_07030	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A8O17_07035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8O17_07040	COG0436	Aminotransferase
A8O17_07045	COG1850	ribulose-bisphosphate carboxylase activity
A8O17_07050	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
A8O17_07055	COG0235	Class ii aldolase
A8O17_07060	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A8O17_07065	COG3339	Conserved Protein
A8O17_07080	COG3852	Histidine kinase
A8O17_07085	COG1846	Transcriptional regulator
A8O17_07090	COG1360	Flagellar Motor Protein
A8O17_07095	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A8O17_07100	COG0542	response to heat
A8O17_07105	COG3949	Membrane
A8O17_07110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A8O17_07115	COG0720	synthase
A8O17_07120	COG0602	queuosine metabolic process
A8O17_07125	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8O17_07130	COG1733	regulation of RNA biosynthetic process
A8O17_07135	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_07140	COG4641	Protein conserved in bacteria
A8O17_07140	COG1388	LysM domain
A8O17_07145	COG1388	LysM domain
A8O17_07150	COG3858	chitin binding
A8O17_07155	COG3858	chitin binding
A8O17_07165	COG4873	Protein conserved in bacteria
A8O17_07180	COG3773	Cell wall hydrolase
A8O17_07185	COG2244	polysaccharide biosynthetic process
A8O17_07190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8O17_07195	COG2217	Heavy metal translocating P-type atpase
A8O17_07205	COG0006	proline dipeptidase activity
A8O17_07215	COG1609	Transcriptional regulator
A8O17_07220	COG3711	transcriptional antiterminator
A8O17_07225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_07225	COG2190	(PTS) system
A8O17_07225	COG1263	PTS System
A8O17_07230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8O17_07235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8O17_07245	COG1533	DNA photolyase activity
A8O17_07250	COG0456	acetyltransferase
A8O17_07255	COG0840	transmembrane signaling receptor activity
A8O17_07260	COG2084	Dehydrogenase
A8O17_07265	COG2340	Cysteine-rich secretory protein family
A8O17_07270	COG0768	penicillin binding
A8O17_07275	COG4191	Histidine kinase
A8O17_07280	COG0436	Aminotransferase
A8O17_07290	COG0784	Response regulator, receiver
A8O17_07290	COG0835	chemotaxis
A8O17_07300	COG2814	Major facilitator Superfamily
A8O17_07305	COG1376	ErfK ybiS ycfS ynhG family protein
A8O17_07310	COG1408	metallophosphoesterase
A8O17_07315	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_07320	COG3409	Peptidoglycan-binding domain 1 protein
A8O17_07325	COG3409	Peptidoglycan-binding domain 1 protein
A8O17_07335	COG2200	EAL domain
A8O17_07345	COG4703	Protein of unknown function (DUF1797)
A8O17_07350	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A8O17_07360	COG0517	IMP dehydrogenase activity
A8O17_07365	COG0583	DNA-binding transcription factor activity
A8O17_07370	COG0716	FMN binding
A8O17_07380	COG0716	FMN binding
A8O17_07385	COG2171	N-acyltransferase activity
A8O17_07390	COG1473	amidohydrolase
A8O17_07400	COG0668	transmembrane transport
A8O17_07405	COG0450	alkyl hydroperoxide reductase
A8O17_07410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8O17_07425	COG0746	molybdenum cofactor guanylyltransferase activity
A8O17_07430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8O17_07435	COG0303	'Molybdopterin
A8O17_07440	COG1763	Mo-molybdopterin cofactor biosynthetic process
A8O17_07445	COG0314	molybdopterin synthase activity
A8O17_07450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A8O17_07455	COG1132	(ABC) transporter
A8O17_07460	COG1132	(ABC) transporter
A8O17_07470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8O17_07475	COG1136	(ABC) transporter
A8O17_07480	COG0577	efflux transmembrane transporter activity
A8O17_07485	COG1349	DNA-binding transcription factor activity
A8O17_07490	COG1105	Belongs to the carbohydrate kinase PfkB family
A8O17_07495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8O17_07495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8O17_07495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8O17_07500	COG0681	Belongs to the peptidase S26 family
A8O17_07510	COG0488	(ABC) transporter
A8O17_07515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8O17_07520	COG2309	aminopeptidase activity
A8O17_07530	COG1077	Cell shape determining protein MreB Mrl
A8O17_07535	COG2002	toxin-antitoxin pair type II binding
A8O17_07540	COG3852	Histidine kinase
A8O17_07545	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A8O17_07545	COG2105	PFAM AIG2 family protein
A8O17_07550	COG0569	domain protein
A8O17_07555	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A8O17_07560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A8O17_07570	COG0561	phosphatase activity
A8O17_07575	COG0242	peptide deformylase activity
A8O17_07585	COG0497	DNA recombination
A8O17_07590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8O17_07595	COG0022	dehydrogenase e1 component
A8O17_07600	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8O17_07605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8O17_07610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8O17_07615	COG1982	Orn Lys Arg decarboxylase major
A8O17_07620	COG4476	Belongs to the UPF0223 family
A8O17_07625	COG4493	Belongs to the UPF0637 family
A8O17_07635	COG0483	inositol monophosphate 1-phosphatase activity
A8O17_07645	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A8O17_07665	COG1595	DNA-templated transcription, initiation
A8O17_07695	COG4896	Protein conserved in bacteria
A8O17_07705	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A8O17_07710	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8O17_07715	COG2066	Belongs to the glutaminase family
A8O17_07720	COG4838	Belongs to the UPF0358 family
A8O17_07725	COG0772	Belongs to the SEDS family
A8O17_07730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A8O17_07735	COG1612	heme a metabolic process
A8O17_07740	COG0109	protoheme IX farnesyltransferase activity
A8O17_07745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8O17_07745	COG2010	Cytochrome c
A8O17_07750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8O17_07755	COG1845	cytochrome c oxidase, subunit III
A8O17_07760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8O17_07765	COG3336	cytochrome c oxidase
A8O17_07775	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A8O17_07780	COG2340	Cysteine-rich secretory protein family
A8O17_07795	COG3679	Belongs to the UPF0342 family
A8O17_07800	COG4471	UPF0298 protein
A8O17_07805	COG0742	ribosomal rna small subunit methyltransferase
A8O17_07810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8O17_07815	COG3314	Sporulation integral membrane protein YlbJ
A8O17_07820	COG1752	Esterase of the alpha-beta hydrolase superfamily
A8O17_07825	COG3480	Lon protease (S16) C-terminal proteolytic domain
A8O17_07830	COG1323	Belongs to the UPF0348 family
A8O17_07840	COG1399	metal-binding, possibly nucleic acid-binding protein
A8O17_07845	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8O17_07855	COG0454	-acetyltransferase
A8O17_07860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8O17_07865	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A8O17_07870	COG2001	Belongs to the MraZ family
A8O17_07875	COG0275	rRNA processing
A8O17_07880	COG4839	cell division protein FtsL
A8O17_07895	COG0768	penicillin binding
A8O17_07905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8O17_07915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8O17_07920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8O17_07925	COG0772	Belongs to the SEDS family
A8O17_07930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8O17_07935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8O17_07940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8O17_07945	COG3879	Bacterial protein of unknown function (DUF881)
A8O17_07950	COG3879	Bacterial protein of unknown function (DUF881)
A8O17_07955	COG3856	small basic protein
A8O17_07960	COG0849	cell division
A8O17_07965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8O17_07970	COG4412	M6 family metalloprotease domain protein
A8O17_07970	COG1404	Belongs to the peptidase S8 family
A8O17_07980	COG1191	sigma factor activity
A8O17_07985	COG1191	sigma factor activity
A8O17_07990	COG1119	ATPase activity
A8O17_07995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8O17_08000	COG1873	PFAM PRC-barrel domain
A8O17_08010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A8O17_08015	COG1799	cell septum assembly
A8O17_08020	COG0762	integral membrane protein
A8O17_08025	COG2302	S4 RNA-binding domain
A8O17_08030	COG3599	regulation of cell shape
A8O17_08035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8O17_08040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8O17_08045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A8O17_08050	COG0564	pseudouridine synthase activity
A8O17_08055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A8O17_08060	COG2233	PERMEase
A8O17_08065	COG0540	Belongs to the ATCase OTCase family
A8O17_08070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8O17_08075	COG0505	Belongs to the CarA family
A8O17_08080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8O17_08085	COG0543	2 iron, 2 sulfur cluster binding
A8O17_08090	COG0167	dihydroorotate dehydrogenase activity
A8O17_08095	COG0284	orotidine-5'-phosphate decarboxylase activity
A8O17_08100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8O17_08105	COG0175	sulfate reduction
A8O17_08110	COG0306	phosphate transporter
A8O17_08115	COG2046	Belongs to the sulfate adenylyltransferase family
A8O17_08120	COG0529	Catalyzes the synthesis of activated sulfate
A8O17_08125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8O17_08130	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
A8O17_08135	COG1648	precorrin-2 dehydrogenase activity
A8O17_08145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A8O17_08150	COG1561	YicC-like family, N-terminal region
A8O17_08155	COG2052	Domain of unknown function (DUF370)
A8O17_08160	COG0194	GDP metabolic process
A8O17_08165	COG1758	RNA polymerase activity
A8O17_08170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8O17_08175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8O17_08180	COG0242	peptide deformylase activity
A8O17_08185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8O17_08190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8O17_08190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8O17_08195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A8O17_08200	COG0631	protein serine/threonine phosphatase activity
A8O17_08205	COG2815	serine threonine protein kinase
A8O17_08205	COG0515	serine threonine protein kinase
A8O17_08210	COG1162	GTPase activity
A8O17_08215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8O17_08220	COG1564	THIamine pyrophosphokinase
A8O17_08230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8O17_08235	COG1302	Protein conserved in bacteria
A8O17_08240	COG1461	Dihydroxyacetone kinase
A8O17_08245	COG1760	l-serine dehydratase
A8O17_08250	COG1760	l-serine dehydratase
A8O17_08255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A8O17_08260	COG2050	protein possibly involved in aromatic compounds catabolism
A8O17_08260	COG1349	DNA-binding transcription factor activity
A8O17_08265	COG0416	fatty acid biosynthetic process
A8O17_08270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8O17_08275	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_08280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8O17_08285	COG0571	ribonuclease III activity
A8O17_08290	COG1196	nuclear chromosome segregation
A8O17_08295	COG0552	protein localization to endoplasmic reticulum
A8O17_08305	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A8O17_08310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8O17_08315	COG0228	four-way junction DNA binding
A8O17_08320	COG1837	Belongs to the UPF0109 family
A8O17_08330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A8O17_08335	COG0336	Belongs to the RNA methyltransferase TrmD family
A8O17_08340	COG0335	large ribosomal subunit rRNA binding
A8O17_08345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A8O17_08350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8O17_08360	COG2257	FlhB HrpN YscU SpaS Family
A8O17_08365	COG0045	succinate-CoA ligase (ADP-forming) activity
A8O17_08370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A8O17_08375	COG0758	DNA mediated transformation
A8O17_08380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8O17_08385	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A8O17_08390	COG4974	Belongs to the 'phage' integrase family
A8O17_08395	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A8O17_08400	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A8O17_08405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A8O17_08410	COG1815	bacterial-type flagellum-dependent cell motility
A8O17_08415	COG1558	bacterial-type flagellum-dependent cell motility
A8O17_08420	COG1677	Flagellar hook-basal body complex protein FliE
A8O17_08425	COG1766	The M ring may be actively involved in energy transduction
A8O17_08430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8O17_08435	COG1317	bacterial-type flagellum organization
A8O17_08440	COG1157	protein secretion by the type III secretion system
A8O17_08445	COG2882	bacterial-type flagellum organization
A8O17_08450	COG3334	PFAM MgtE intracellular
A8O17_08455	COG3144	bacterial-type flagellum assembly
A8O17_08460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A8O17_08465	COG4786	Flagellar basal body rod
A8O17_08470	COG1582	Flagellar protein (FlbD)
A8O17_08475	COG1580	Controls the rotational direction of flagella during chemotaxis
A8O17_08480	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8O17_08485	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8O17_08485	COG1776	CheC inhibitor of MCP methylation
A8O17_08490	COG2201	protein-glutamate methylesterase activity
A8O17_08495	COG3190	flagellar
A8O17_08500	COG1338	Plays a role in the flagellum-specific transport system
A8O17_08505	COG1987	bacterial-type flagellum assembly
A8O17_08510	COG1684	flagellar biosynthetic protein fliR
A8O17_08515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8O17_08520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8O17_08525	COG1419	protein localization to endoplasmic reticulum
A8O17_08530	COG0455	bacterial-type flagellum organization
A8O17_08535	COG2201	protein-glutamate methylesterase activity
A8O17_08540	COG2198	Histidine kinase
A8O17_08540	COG0643	Histidine kinase
A8O17_08545	COG0835	chemotaxis
A8O17_08550	COG1776	CheC inhibitor of MCP methylation
A8O17_08555	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A8O17_08560	COG1191	sigma factor activity
A8O17_08570	COG0052	Belongs to the universal ribosomal protein uS2 family
A8O17_08575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A8O17_08580	COG0528	UMP kinase activity
A8O17_08585	COG0233	cytoplasmic translational termination
A8O17_08590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8O17_08595	COG4589	Belongs to the CDS family
A8O17_08600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A8O17_08605	COG0750	zinc metalloprotease
A8O17_08610	COG0442	prolyl-tRNA aminoacylation
A8O17_08615	COG2176	DNA-directed DNA polymerase activity
A8O17_08620	COG0779	Required for maturation of 30S ribosomal subunits
A8O17_08625	COG0195	Participates in both transcription termination and antitermination
A8O17_08630	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A8O17_08635	COG1358	cellular component organization or biogenesis
A8O17_08640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8O17_08645	COG1550	Protein conserved in bacteria
A8O17_08650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8O17_08655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8O17_08660	COG0196	riboflavin kinase activity
A8O17_08665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A8O17_08670	COG1185	polyribonucleotide nucleotidyltransferase activity
A8O17_08675	COG0726	polysaccharide deacetylase
A8O17_08680	COG0612	Peptidase, M16
A8O17_08685	COG1873	PFAM PRC-barrel domain
A8O17_08695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8O17_08700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8O17_08705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8O17_08710	COG0527	aspartate kinase activity
A8O17_08715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8O17_08720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A8O17_08725	COG0740	serine-type endopeptidase activity
A8O17_08735	COG1674	ftsk spoiiie
A8O17_08735	COG4980	gas vesicle protein
A8O17_08740	COG2188	Transcriptional regulator
A8O17_08745	COG2814	Major facilitator Superfamily
A8O17_08750	COG0612	Peptidase, M16
A8O17_08755	COG0612	Peptidase, M16
A8O17_08760	COG0300	oxidoreductase activity
A8O17_08775	COG1426	Protein conserved in bacteria
A8O17_08780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8O17_08785	COG1058	Belongs to the CinA family
A8O17_08785	COG1546	Belongs to the CinA family
A8O17_08790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A8O17_08795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8O17_08800	COG1418	mRNA catabolic process
A8O17_08805	COG1692	metallophosphoesterase
A8O17_08810	COG2359	stage V sporulation protein S
A8O17_08815	COG1063	alcohol dehydrogenase
A8O17_08820	COG0156	8-amino-7-oxononanoate synthase activity
A8O17_08825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8O17_08830	COG4550	Control of competence regulator ComK, YlbF/YmcA
A8O17_08840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8O17_08845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A8O17_08870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8O17_08870	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A8O17_08870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8O17_08870	COG3321	synthase
A8O17_08875	COG2124	cytochrome p450
A8O17_08885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8O17_08890	COG1404	Belongs to the peptidase S8 family
A8O17_08900	COG4195	phage-related replication protein
A8O17_08905	COG1764	response to oxidative stress
A8O17_08910	COG2076	Multidrug Resistance protein
A8O17_08915	COG2076	Multidrug Resistance protein
A8O17_08930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A8O17_08935	COG1923	regulation of RNA biosynthetic process
A8O17_08950	COG1780	Probably involved in ribonucleotide reductase function
A8O17_08955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8O17_08960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8O17_08965	COG4112	unkown
A8O17_08970	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8O17_08975	COG0464	growth
A8O17_08985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8O17_08990	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A8O17_08995	COG0789	Transcriptional regulator
A8O17_09000	COG0174	glutamine synthetase
A8O17_09020	COG4282	regulation of fungal-type cell wall biogenesis
A8O17_09030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8O17_09055	COG0135	phosphoribosylanthranilate isomerase activity
A8O17_09060	COG2211	Major facilitator Superfamily
A8O17_09065	COG3507	Belongs to the glycosyl hydrolase 43 family
A8O17_09070	COG1940	carbohydrate kinase activity
A8O17_09075	COG2115	Belongs to the xylose isomerase family
A8O17_09080	COG1070	Carbohydrate kinase
A8O17_09085	COG1525	nuclease
A8O17_09090	COG2814	Major facilitator Superfamily
A8O17_09095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8O17_09105	COG0756	dUTP diphosphatase activity
A8O17_09115	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8O17_09140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8O17_09155	COG3832	glyoxalase III activity
A8O17_09170	COG0697	spore germination
A8O17_09175	COG0531	amino acid
A8O17_09205	COG4195	phage-related replication protein
A8O17_09215	COG0346	lactoylglutathione lyase activity
A8O17_09225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A8O17_09230	COG1388	LysM domain
A8O17_09235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A8O17_09240	COG4224	UPF0291 protein
A8O17_09245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A8O17_09255	COG3763	UPF0154 protein
A8O17_09265	COG0785	Cytochrome C biogenesis protein
A8O17_09270	COG2201	protein-glutamate methylesterase activity
A8O17_09275	COG4846	Membrane protein involved in cytochrome C biogenesis
A8O17_09285	COG0071	Belongs to the small heat shock protein (HSP20) family
A8O17_09300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8O17_09305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8O17_09325	COG0824	Thioesterase
A8O17_09335	COG4841	protein insertion into membrane
A8O17_09340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8O17_09345	COG1832	CoA-binding protein
A8O17_09350	COG0187	DNA topoisomerase II activity
A8O17_09355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8O17_09370	COG1115	amino acid carrier protein
A8O17_09375	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A8O17_09385	COG5520	Belongs to the glycosyl hydrolase 30 family
A8O17_09390	COG3507	Belongs to the glycosyl hydrolase 43 family
A8O17_09400	COG2246	polysaccharide biosynthetic process
A8O17_09405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8O17_09410	COG0586	Pfam SNARE associated Golgi protein
A8O17_09415	COG2404	hydrolase activity, acting on ester bonds
A8O17_09420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8O17_09425	COG1024	Enoyl-CoA hydratase
A8O17_09430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8O17_09435	COG0511	ligase activity, forming carbon-carbon bonds
A8O17_09440	COG0439	Biotin carboxylase
A8O17_09445	COG0318	PFAM AMP-dependent synthetase and ligase
A8O17_09450	COG1960	acyl-CoA dehydrogenase activity
A8O17_09465	COG1649	PFAM Uncharacterised BCR, COG1649
A8O17_09475	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A8O17_09475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_09480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_09485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_09490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_09495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_09500	COG2027	D-alanyl-D-alanine carboxypeptidase
A8O17_09505	COG2017	converts alpha-aldose to the beta-anomer
A8O17_09510	COG0534	Mate efflux family protein
A8O17_09525	COG0582	viral genome integration into host DNA
A8O17_09530	COG0166	Belongs to the GPI family
A8O17_09535	COG0405	Gamma-glutamyltransferase
A8O17_09540	COG0583	DNA-binding transcription factor activity
A8O17_09545	COG0604	alcohol dehydrogenase
A8O17_09550	COG0493	'glutamate synthase
A8O17_09555	COG0070	glutamate synthase
A8O17_09555	COG0069	glutamate synthase activity
A8O17_09555	COG0067	glutamate synthase
A8O17_09560	COG0583	DNA-binding transcription factor activity
A8O17_09565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8O17_09570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8O17_09580	COG0300	oxidoreductase activity
A8O17_09585	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A8O17_09595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8O17_09600	COG2814	Major facilitator Superfamily
A8O17_09605	COG1070	Carbohydrate kinase
A8O17_09610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8O17_09615	COG0243	molybdopterin cofactor binding
A8O17_09640	COG0840	transmembrane signaling receptor activity
A8O17_09640	COG5278	phosphoserine phosphatase activity
A8O17_09645	COG2368	4-hydroxyphenylacetate
A8O17_09650	COG4305	rare lipoprotein A
A8O17_09655	COG3619	membrane
A8O17_09660	COG3866	Pectate lyase
A8O17_09665	COG2135	peptidase activity
A8O17_09675	COG2140	Oxalate decarboxylase
A8O17_09685	COG0456	acetyltransferase
A8O17_09705	COG2720	vancomycin resistance protein
A8O17_09715	COG3655	Transcriptional regulator
A8O17_09720	COG3739	integral membrane protein
A8O17_09725	COG0583	DNA-binding transcription factor activity
A8O17_09730	COG0697	spore germination
A8O17_09740	COG0693	protein deglycase activity
A8O17_09745	COG2367	Beta-lactamase
A8O17_09765	COG3848	Pyruvate phosphate dikinase
A8O17_09765	COG0574	Belongs to the PEP-utilizing enzyme family
A8O17_09770	COG0726	polysaccharide deacetylase
A8O17_09780	COG2314	TM2 domain
A8O17_09785	COG1396	sequence-specific DNA binding
A8O17_09800	COG2135	peptidase activity
A8O17_09805	COG1793	dna ligase
A8O17_09835	COG0457	Tetratricopeptide repeat
A8O17_09860	COG5290	Psort location Cytoplasmic, score
A8O17_09880	COG5444	nuclease activity
A8O17_09885	COG4282	regulation of fungal-type cell wall biogenesis
A8O17_09890	COG1231	oxidoreductase activity
A8O17_09895	COG5434	Belongs to the glycosyl hydrolase 28 family
A8O17_09900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8O17_09905	COG0662	Cupin 2, conserved barrel domain protein
A8O17_09905	COG2207	Transcriptional regulator
A8O17_09910	COG0456	acetyltransferase
A8O17_09915	COG1309	transcriptional regulator
A8O17_09920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8O17_09925	COG3708	Transcriptional regulator
A8O17_09930	COG2378	regulation of single-species biofilm formation
A8O17_09940	COG0640	Transcriptional regulator
A8O17_09945	COG0741	lytic transglycosylase activity
A8O17_09950	COG2322	membrane
A8O17_09965	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8O17_09970	COG3239	Fatty acid desaturase
A8O17_09975	COG4585	Histidine kinase
A8O17_09980	COG2197	response regulator
A8O17_09985	COG3584	3D domain protein
A8O17_09985	COG1388	LysM domain
A8O17_09990	COG0514	ATP-dependent DNA helicase (RecQ)
A8O17_10005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8O17_10010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8O17_10025	COG0071	Belongs to the small heat shock protein (HSP20) family
A8O17_10050	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_10055	COG1657	PFAM Prenyltransferase squalene oxidase
A8O17_10060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8O17_10065	COG0733	neurotransmitter:sodium symporter activity
A8O17_10070	COG0385	Bile acid
A8O17_10075	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8O17_10080	COG0567	Dehydrogenase, E1 component
A8O17_10085	COG4548	von Willebrand factor, type A
A8O17_10090	COG0714	Associated with various cellular activities
A8O17_10095	COG2032	superoxide dismutase activity
A8O17_10100	COG1388	LysM domain
A8O17_10100	COG0791	NLP P60 protein
A8O17_10105	COG1819	glycosyl
A8O17_10110	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A8O17_10115	COG0534	Mate efflux family protein
A8O17_10120	COG1366	Belongs to the anti-sigma-factor antagonist family
A8O17_10125	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8O17_10130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8O17_10140	COG2962	Rard protein
A8O17_10155	COG2610	gluconate transmembrane transporter activity
A8O17_10160	COG1942	4-Oxalocrotonate Tautomerase
A8O17_10165	COG1733	regulation of RNA biosynthetic process
A8O17_10170	COG0778	Nitroreductase
A8O17_10175	COG0400	carboxylic ester hydrolase activity
A8O17_10180	COG0346	lactoylglutathione lyase activity
A8O17_10190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8O17_10195	COG0793	Belongs to the peptidase S41A family
A8O17_10195	COG3409	Peptidoglycan-binding domain 1 protein
A8O17_10200	COG2226	methyltransferase
A8O17_10210	COG1876	peptidase activity
A8O17_10215	COG0813	purine-nucleoside phosphorylase activity
A8O17_10230	COG0671	phosphoesterase, PA-phosphatase related
A8O17_10255	COG4479	Belongs to the UPF0346 family
A8O17_10265	COG1509	lysine 2,3-aminomutase activity
A8O17_10270	COG0456	acetyltransferase
A8O17_10275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8O17_10280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8O17_10285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A8O17_10290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8O17_10305	COG0456	acetyltransferase
A8O17_10310	COG0463	Glycosyl transferase, family 2
A8O17_10325	COG4641	Protein conserved in bacteria
A8O17_10330	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
A8O17_10335	COG1086	Polysaccharide biosynthesis protein
A8O17_10340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8O17_10345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8O17_10350	COG1846	Transcriptional regulator
A8O17_10355	COG0534	Mate efflux family protein
A8O17_10365	COG4698	Protein conserved in bacteria
A8O17_10370	COG2755	lipolytic protein G-D-S-L family
A8O17_10375	COG1999	signal sequence binding
A8O17_10390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8O17_10395	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A8O17_10400	COG1272	protein, Hemolysin III
A8O17_10405	COG0204	Acyl-transferase
A8O17_10410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8O17_10415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8O17_10420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A8O17_10430	COG2521	methyltransferase
A8O17_10430	COG2136	Putative SAM-dependent methyltransferase
A8O17_10440	COG0129	dihydroxy-acid dehydratase activity
A8O17_10445	COG1413	lyase activity
A8O17_10450	COG1418	mRNA catabolic process
A8O17_10455	COG0386	Belongs to the glutathione peroxidase family
A8O17_10460	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A8O17_10465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8O17_10470	COG1278	Cold shock
A8O17_10490	COG0328	RNA-DNA hybrid ribonuclease activity
A8O17_10495	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A8O17_10500	COG0328	RNA-DNA hybrid ribonuclease activity
A8O17_10510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8O17_10530	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A8O17_10535	COG1755	Isoprenylcysteine carboxyl methyltransferase
A8O17_10540	COG3424	synthase
A8O17_10545	COG2233	PERMEase
A8O17_10550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8O17_10555	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A8O17_10565	COG0800	Aldolase
A8O17_10570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8O17_10575	COG1609	Transcriptional regulator
A8O17_10580	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A8O17_10585	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_10590	COG1199	ATP-dependent helicase activity
A8O17_10600	COG0116	Belongs to the methyltransferase superfamily
A8O17_10615	COG4474	Belongs to the UPF0398 family
A8O17_10625	COG3359	exonuclease
A8O17_10630	COG1111	helicase
A8O17_10630	COG1205	dead DEAH box helicase
A8O17_10635	COG2190	(PTS) system
A8O17_10640	COG0071	Belongs to the small heat shock protein (HSP20) family
A8O17_10675	COG3331	DNA recombination
A8O17_10680	COG4499	WXG100 protein secretion system (Wss), protein YukC
A8O17_10680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8O17_10690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A8O17_10695	COG3935	DnaD domain protein
A8O17_10700	COG0017	Asparaginyl-tRNA synthetase
A8O17_10705	COG0436	Aminotransferase
A8O17_10710	COG5353	protein conserved in bacteria
A8O17_10720	COG1199	ATP-dependent helicase activity
A8O17_10720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8O17_10725	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A8O17_10730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A8O17_10735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A8O17_10740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A8O17_10740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A8O17_10745	COG0617	tRNA 3'-terminal CCA addition
A8O17_10750	COG0438	transferase activity, transferring glycosyl groups
A8O17_10755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8O17_10760	COG1803	Methylglyoxal synthase
A8O17_10765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A8O17_10770	COG1694	Mazg nucleotide pyrophosphohydrolase
A8O17_10775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8O17_10785	COG4347	Protein of unknown function (DUF1405)
A8O17_10790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8O17_10790	COG2010	Cytochrome c
A8O17_10795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8O17_10800	COG0723	plastoquinol--plastocyanin reductase activity
A8O17_10810	COG5582	Belongs to the UPF0302 family
A8O17_10815	COG0457	Tetratricopeptide repeat
A8O17_10820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8O17_10825	COG0287	Prephenate dehydrogenase
A8O17_10830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8O17_10835	COG0159	tryptophan synthase activity
A8O17_10840	COG0133	tryptophan synthase activity
A8O17_10845	COG0135	phosphoribosylanthranilate isomerase activity
A8O17_10855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8O17_10860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8O17_10865	COG4401	Chorismate mutase type I
A8O17_10870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8O17_10875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8O17_10880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A8O17_10890	COG0105	UTP biosynthetic process
A8O17_10895	COG0142	geranyltranstransferase activity
A8O17_10900	COG2226	methyltransferase
A8O17_10905	COG0142	geranyltranstransferase activity
A8O17_10915	COG0302	gtp cyclohydrolase
A8O17_10920	COG0776	regulation of translation
A8O17_10925	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A8O17_10940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8O17_10945	COG1160	GTP binding
A8O17_10970	COG1304	FMN binding
A8O17_10975	COG0539	negative regulation of cytoplasmic translation
A8O17_10980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A8O17_10990	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A8O17_10995	COG2959	enzyme of heme biosynthesis
A8O17_11000	COG3409	Peptidoglycan-binding domain 1 protein
A8O17_11000	COG3773	Cell wall hydrolase
A8O17_11005	COG2339	peptidase activity
A8O17_11010	COG0492	ferredoxin-NADP+ reductase activity
A8O17_11015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8O17_11020	COG4862	establishment of competence for transformation
A8O17_11025	COG1408	metallophosphoesterase
A8O17_11035	COG1388	LysM domain
A8O17_11040	COG1266	CAAX protease self-immunity
A8O17_11045	COG0514	ATP-dependent DNA helicase (RecQ)
A8O17_11050	COG4955	Helix-turn-helix domain
A8O17_11055	COG1141	Ferredoxin
A8O17_11060	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A8O17_11065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8O17_11070	COG0710	3-dehydroquinate dehydratase activity
A8O17_11080	COG1595	DNA-templated transcription, initiation
A8O17_11085	COG5002	protein histidine kinase activity
A8O17_11090	COG0745	RESPONSE REGULATOR receiver
A8O17_11095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8O17_11100	COG1333	cytochrome c biogenesis protein
A8O17_11105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8O17_11110	COG1187	pseudouridine synthase activity
A8O17_11115	COG0700	Nucleoside recognition
A8O17_11120	COG2715	membrane protein required for spore maturation
A8O17_11125	COG1686	Belongs to the peptidase S11 family
A8O17_11135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A8O17_11140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A8O17_11145	COG1547	Domain of unknown function (DUF309)
A8O17_11150	COG0456	acetyltransferase
A8O17_11155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8O17_11160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8O17_11160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8O17_11165	COG0307	riboflavin synthase, alpha
A8O17_11170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8O17_11170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8O17_11180	COG0681	Belongs to the peptidase S26 family
A8O17_11185	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
A8O17_11210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8O17_11215	COG4086	secreted protein
A8O17_11220	COG0019	diaminopimelate decarboxylase activity
A8O17_11225	COG0697	spore germination
A8O17_11240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8O17_11260	COG1191	sigma factor activity
A8O17_11265	COG2172	sigma factor antagonist activity
A8O17_11270	COG1366	Belongs to the anti-sigma-factor antagonist family
A8O17_11275	COG1686	Belongs to the peptidase S11 family
A8O17_11280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A8O17_11285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A8O17_11290	COG4974	Belongs to the 'phage' integrase family
A8O17_11300	COG0735	belongs to the Fur family
A8O17_11305	COG1300	Membrane
A8O17_11315	COG0281	malic enzyme
A8O17_11320	COG1757	Na H antiporter
A8O17_11325	COG1027	Aspartate ammonia-lyase
A8O17_11330	COG0252	asparaginase activity
A8O17_11335	COG1396	sequence-specific DNA binding
A8O17_11340	COG1379	DNA repair
A8O17_11345	COG0494	nUDIX hydrolase
A8O17_11355	COG0667	Aldo Keto reductase
A8O17_11365	COG1073	alpha beta
A8O17_11375	COG4918	Iron-sulphur cluster biosynthesis
A8O17_11380	COG0456	acetyltransferase
A8O17_11380	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A8O17_11385	COG2329	Antibiotic biosynthesis monooxygenase
A8O17_11390	COG0456	acetyltransferase
A8O17_11400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8O17_11410	COG2211	Major facilitator Superfamily
A8O17_11420	COG0346	lactoylglutathione lyase activity
A8O17_11425	COG1072	(Pantothenic acid kinase))
A8O17_11430	COG3048	D-serine ammonia-lyase activity
A8O17_11435	COG0300	oxidoreductase activity
A8O17_11440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8O17_11445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8O17_11450	COG4187	Peptidase family M20/M25/M40
A8O17_11455	COG1902	pentaerythritol trinitrate reductase activity
A8O17_11460	COG0596	Alpha beta hydrolase
A8O17_11465	COG1234	tRNA 3'-trailer cleavage
A8O17_11470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A8O17_11475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8O17_11480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8O17_11490	COG0706	membrane insertase activity
A8O17_11495	COG3361	conserved protein (COG2071)
A8O17_11500	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8O17_11505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8O17_11510	COG0346	lactoylglutathione lyase activity
A8O17_11520	COG1376	ErfK ybiS ycfS ynhG family protein
A8O17_11525	COG4129	membrane
A8O17_11530	COG1126	abc transporter atp-binding protein
A8O17_11535	COG0765	amino acid transport
A8O17_11540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8O17_11550	COG1597	lipid kinase activity
A8O17_11555	COG2814	Major facilitator Superfamily
A8O17_11560	COG4978	Transcriptional regulator
A8O17_11560	COG0789	Transcriptional regulator
A8O17_11565	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8O17_11570	COG0022	dehydrogenase e1 component
A8O17_11575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8O17_11580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8O17_11585	COG3426	butyrate kinase activity
A8O17_11590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8O17_11595	COG0280	phosphate acetyltransferase
A8O17_11600	COG3829	transcription factor binding
A8O17_11600	COG3290	protein histidine kinase activity
A8O17_11610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A8O17_11615	COG2079	MmgE PrpD family protein
A8O17_11620	COG0372	Belongs to the citrate synthase family
A8O17_11625	COG1960	acyl-CoA dehydrogenase activity
A8O17_11630	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8O17_11635	COG0183	Belongs to the thiolase family
A8O17_11640	COG0584	glycerophosphoryl diester phosphodiesterase
A8O17_11645	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8O17_11660	COG1902	pentaerythritol trinitrate reductase activity
A8O17_11670	COG0745	RESPONSE REGULATOR receiver
A8O17_11680	COG0750	zinc metalloprotease
A8O17_11685	COG0497	DNA recombination
A8O17_11690	COG1438	arginine binding
A8O17_11695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A8O17_11700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8O17_11705	COG0142	geranyltranstransferase activity
A8O17_11710	COG1722	exodeoxyribonuclease VII activity
A8O17_11715	COG1570	exodeoxyribonuclease VII activity
A8O17_11720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8O17_11725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8O17_11730	COG1302	Protein conserved in bacteria
A8O17_11735	COG0439	Biotin carboxylase
A8O17_11740	COG0511	ligase activity, forming carbon-carbon bonds
A8O17_11780	COG3854	ATPases associated with a variety of cellular activities
A8O17_11790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8O17_11795	COG0006	proline dipeptidase activity
A8O17_11800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A8O17_11810	COG3872	metal-dependent enzyme
A8O17_11820	COG1752	Esterase of the alpha-beta hydrolase superfamily
A8O17_11825	COG1321	iron dependent repressor
A8O17_11830	COG0095	Lipoate-protein ligase
A8O17_11835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8O17_11840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8O17_11845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8O17_11850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8O17_11855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8O17_11870	COG1396	sequence-specific DNA binding
A8O17_11880	COG0681	Belongs to the peptidase S26 family
A8O17_11905	COG4940	Competence protein ComGF
A8O17_11915	COG4970	Tfp pilus assembly protein FimT
A8O17_11920	COG4537	Required for transformation and DNA binding
A8O17_11925	COG1459	type II secretion system
A8O17_11930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A8O17_11940	COG0598	Magnesium transport protein CorA
A8O17_11945	COG1253	flavin adenine dinucleotide binding
A8O17_11950	COG1366	Belongs to the anti-sigma-factor antagonist family
A8O17_11960	COG1393	Belongs to the ArsC family
A8O17_11970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8O17_11980	COG0011	TIGRFAM Protein of
A8O17_11990	COG2866	Carboxypeptidase
A8O17_11995	COG1368	sulfuric ester hydrolase activity
A8O17_12000	COG1940	carbohydrate kinase activity
A8O17_12005	COG4483	Protein conserved in bacteria
A8O17_12010	COG0705	Rhomboid family
A8O17_12010	COG0457	Tetratricopeptide repeat
A8O17_12020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8O17_12025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8O17_12030	COG0438	transferase activity, transferring glycosyl groups
A8O17_12045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8O17_12050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8O17_12055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8O17_12060	COG0581	inorganic phosphate transmembrane transporter activity
A8O17_12065	COG0573	inorganic phosphate transmembrane transporter activity
A8O17_12070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A8O17_12080	COG0477	Major facilitator Superfamily
A8O17_12085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8O17_12090	COG2839	Protein conserved in bacteria
A8O17_12095	COG5521	maltodextrose utilization protein MalA
A8O17_12105	COG1388	LysM domain
A8O17_12110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A8O17_12115	COG4709	membrane
A8O17_12120	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
A8O17_12125	COG0735	belongs to the Fur family
A8O17_12130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8O17_12140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A8O17_12145	COG0513	Belongs to the DEAD box helicase family
A8O17_12155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A8O17_12160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8O17_12165	COG2384	SAM-dependent methyltransferase
A8O17_12170	COG2010	Cytochrome c
A8O17_12175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8O17_12180	COG0358	DNA primase activity
A8O17_12185	COG1671	Belongs to the UPF0178 family
A8O17_12190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A8O17_12195	COG0517	IMP dehydrogenase activity
A8O17_12200	COG0751	glycine-tRNA ligase activity
A8O17_12205	COG0752	glycyl-tRNA synthetase alpha subunit
A8O17_12210	COG1381	Involved in DNA repair and RecF pathway recombination
A8O17_12220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8O17_12225	COG0295	cytidine deaminase activity
A8O17_12230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A8O17_12235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A8O17_12240	COG1480	7TM receptor with intracellular HD hydrolase
A8O17_12250	COG1702	phosphate starvation-inducible protein PhoH
A8O17_12255	COG0561	phosphatase activity
A8O17_12270	COG4864	UPF0365 protein
A8O17_12275	COG1030	water channel activity
A8O17_12280	COG1610	YqeY-like protein
A8O17_12285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A8O17_12290	COG1283	sodium-dependent phosphate transmembrane transporter activity
A8O17_12295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8O17_12300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8O17_12305	COG2264	protein methyltransferase activity
A8O17_12310	COG0484	heat shock protein binding
A8O17_12315	COG0443	Heat shock 70 kDa protein
A8O17_12320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8O17_12325	COG1420	regulation of RNA biosynthetic process
A8O17_12330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8O17_12335	COG0481	GTPase activity
A8O17_12345	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8O17_12350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A8O17_12355	COG0268	Binds directly to 16S ribosomal RNA
A8O17_12360	COG1466	dna polymerase III delta subunit
A8O17_12370	COG2333	competence protein COMEC
A8O17_12370	COG0658	competence protein
A8O17_12375	COG2131	deaminase
A8O17_12380	COG1555	photosystem II stabilization
A8O17_12380	COG1596	polysaccharide export
A8O17_12385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8O17_12390	COG2226	methyltransferase
A8O17_12395	COG0799	negative regulation of ribosome biogenesis
A8O17_12400	COG1713	HD superfamily hydrolase involved in NAD metabolism
A8O17_12405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A8O17_12410	COG1534	Rna-binding protein
A8O17_12415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8O17_12420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A8O17_12425	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A8O17_12440	COG2755	lipolytic protein G-D-S-L family
A8O17_12445	COG3409	Peptidoglycan-binding domain 1 protein
A8O17_12445	COG5632	N-Acetylmuramoyl-L-alanine amidase
A8O17_12450	COG0398	Pfam SNARE associated Golgi protein
A8O17_12455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A8O17_12465	COG3209	COG3209 Rhs family protein
A8O17_12475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A8O17_12480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8O17_12500	COG3223	Belongs to the PsiE family
A8O17_12505	COG5002	protein histidine kinase activity
A8O17_12505	COG0642	Histidine kinase
A8O17_12510	COG0745	RESPONSE REGULATOR receiver
A8O17_12515	COG2311	Membrane
A8O17_12525	COG0454	-acetyltransferase
A8O17_12530	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8O17_12540	COG0730	response to heat
A8O17_12545	COG0425	Belongs to the sulfur carrier protein TusA family
A8O17_12550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8O17_12550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8O17_12560	COG0425	Belongs to the sulfur carrier protein TusA family
A8O17_12560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8O17_12565	COG2210	Belongs to the sulfur carrier protein TusA family
A8O17_12570	COG1937	Protein conserved in bacteria
A8O17_12575	COG0662	Cupin 2, conserved barrel domain protein
A8O17_12590	COG4978	Transcriptional regulator
A8O17_12590	COG0789	Transcriptional regulator
A8O17_12595	COG2814	Major facilitator Superfamily
A8O17_12600	COG0456	acetyltransferase
A8O17_12605	COG1253	flavin adenine dinucleotide binding
A8O17_12615	COG0697	spore germination
A8O17_12620	COG0583	DNA-binding transcription factor activity
A8O17_12625	COG2072	flavoprotein involved in K transport
A8O17_12630	COG1230	cation diffusion facilitator family transporter
A8O17_12635	COG1942	4-Oxalocrotonate Tautomerase
A8O17_12640	COG0583	DNA-binding transcription factor activity
A8O17_12650	COG1114	Component of the transport system for branched-chain amino acids
A8O17_12655	COG1687	branched-chain amino acid
A8O17_12660	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A8O17_12665	COG1522	sequence-specific DNA binding
A8O17_12670	COG2732	(Barnase) inhibitor
A8O17_12675	COG2124	cytochrome p450
A8O17_12685	COG1335	isochorismatase
A8O17_12695	COG2318	DinB family
A8O17_12705	COG2070	2-Nitropropane dioxygenase
A8O17_12710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8O17_12725	COG3443	Belongs to the bacterial solute-binding protein 9 family
A8O17_12730	COG1595	DNA-templated transcription, initiation
A8O17_12735	COG0667	Aldo Keto reductase
A8O17_12740	COG2851	Citrate transporter
A8O17_12745	COG0583	DNA-binding transcription factor activity
A8O17_12750	COG2828	Protein conserved in bacteria
A8O17_12755	COG3409	Peptidoglycan-binding domain 1 protein
A8O17_12760	COG5566	PFAM Mor transcription activator
A8O17_12765	COG0596	Alpha beta hydrolase
A8O17_12770	COG4991	sh3 domain protein
A8O17_12775	COG4991	sh3 domain protein
A8O17_12780	COG0346	lactoylglutathione lyase activity
A8O17_12790	COG5577	PFAM Coat F domain
A8O17_12795	COG1063	alcohol dehydrogenase
A8O17_12805	COG5577	PFAM Coat F domain
A8O17_12810	COG0789	Transcriptional regulator
A8O17_12820	COG1064	alcohol dehydrogenase
A8O17_12825	COG0693	protein deglycase activity
A8O17_12830	COG1621	beta-fructofuranosidase activity
A8O17_12835	COG3716	PTS system mannose fructose sorbose family IID component
A8O17_12840	COG3715	PTS system
A8O17_12845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_12850	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8O17_12855	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A8O17_12855	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A8O17_12860	COG1113	amino acid transport
A8O17_12865	COG1280	lysine exporter protein (LysE YggA)
A8O17_12870	COG1378	Sugar-specific transcriptional regulator TrmB
A8O17_12875	COG1595	DNA-templated transcription, initiation
A8O17_12885	COG2755	lipolytic protein G-D-S-L family
A8O17_12885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A8O17_12895	COG2124	cytochrome p450
A8O17_12895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A8O17_12900	COG1309	transcriptional regulator
A8O17_12905	COG2226	methyltransferase
A8O17_12915	COG2116	formate transmembrane transporter activity
A8O17_12920	COG5609	conserved protein (DUF2294)
A8O17_12925	COG3383	formate dehydrogenase (NAD+) activity
A8O17_12930	COG2427	Protein of unknown function (DUF1641)
A8O17_12940	COG0626	cystathionine gamma-synthase activity
A8O17_12945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8O17_12950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8O17_12955	COG2226	methyltransferase
A8O17_12970	COG0768	penicillin binding
A8O17_12975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8O17_12980	COG0572	uridine kinase
A8O17_13000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8O17_13005	COG3906	Belongs to the UPF0473 family
A8O17_13010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8O17_13015	COG4472	Bacterial protein of unknown function (DUF965)
A8O17_13020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8O17_13025	COG0628	permease
A8O17_13030	COG1126	abc transporter atp-binding protein
A8O17_13035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8O17_13040	COG0765	amino acid transport
A8O17_13045	COG0765	amino acid transport
A8O17_13060	COG3881	PFAM PRC-barrel domain
A8O17_13065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8O17_13070	COG0457	Tetratricopeptide repeat
A8O17_13075	COG0482	sulfurtransferase activity
A8O17_13080	COG1104	cysteine desulfurase activity
A8O17_13085	COG1959	2 iron, 2 sulfur cluster binding
A8O17_13090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8O17_13095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A8O17_13105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8O17_13110	COG0124	histidyl-tRNA synthetase
A8O17_13120	COG4991	sh3 domain protein
A8O17_13120	COG3103	Sh3 type 3 domain protein
A8O17_13120	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8O17_13125	COG1490	D-aminoacyl-tRNA deacylase activity
A8O17_13130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8O17_13135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8O17_13140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8O17_13140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A8O17_13145	COG5416	Lipopolysaccharide assembly protein A domain
A8O17_13150	COG0490	domain, Protein
A8O17_13155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8O17_13155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8O17_13165	COG2244	polysaccharide biosynthetic process
A8O17_13170	COG2323	membrane
A8O17_13180	COG1862	Preprotein translocase
A8O17_13185	COG0343	queuine tRNA-ribosyltransferase activity
A8O17_13190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A8O17_13200	COG2255	four-way junction helicase activity
A8O17_13205	COG0632	four-way junction helicase activity
A8O17_13215	COG2814	Major facilitator Superfamily
A8O17_13220	COG0673	inositol 2-dehydrogenase activity
A8O17_13225	COG2112	serine threonine protein kinase
A8O17_13245	COG1115	amino acid carrier protein
A8O17_13250	COG0217	transcriptional regulatory protein
A8O17_13260	COG1388	LysM domain
A8O17_13265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A8O17_13270	COG0157	Belongs to the NadC ModD family
A8O17_13275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A8O17_13280	COG1104	cysteine desulfurase activity
A8O17_13285	COG1827	regulation of RNA biosynthetic process
A8O17_13290	COG0077	Prephenate dehydratase
A8O17_13295	COG4492	Belongs to the UPF0735 family
A8O17_13300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8O17_13305	COG3290	protein histidine kinase activity
A8O17_13315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A8O17_13320	COG2868	ribosomal protein
A8O17_13325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A8O17_13330	COG1994	Peptidase M50
A8O17_13335	COG0739	heme binding
A8O17_13340	COG2894	cell division
A8O17_13345	COG0850	regulation of cytokinetic process
A8O17_13350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A8O17_13355	COG1792	Involved in formation and maintenance of cell shape
A8O17_13360	COG1077	Cell shape determining protein MreB Mrl
A8O17_13365	COG2003	Belongs to the UPF0758 family
A8O17_13370	COG0424	maF-like protein
A8O17_13380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A8O17_13385	COG0285	dihydrofolate synthase activity
A8O17_13390	COG0525	valine-tRNA ligase activity
A8O17_13400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8O17_13405	COG1388	LysM domain
A8O17_13410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8O17_13415	COG0113	porphobilinogen synthase activity
A8O17_13420	COG1587	Uroporphyrinogen-III synthase
A8O17_13425	COG0181	hydroxymethylbilane synthase activity
A8O17_13430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8O17_13435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A8O17_13445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A8O17_13450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A8O17_13455	COG0470	DNA polymerase III
A8O17_13455	COG1067	ATP-dependent peptidase activity
A8O17_13460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8O17_13465	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8O17_13470	COG0457	Tetratricopeptide repeat
A8O17_13470	COG1477	protein flavinylation
A8O17_13475	COG0066	3-isopropylmalate dehydratase activity
A8O17_13480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8O17_13485	COG0473	3-isopropylmalate dehydrogenase activity
A8O17_13490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8O17_13495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8O17_13500	COG0440	acetolactate synthase activity
A8O17_13505	COG0028	Belongs to the TPP enzyme family
A8O17_13515	COG0454	-acetyltransferase
A8O17_13525	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
A8O17_13535	COG0622	Phosphoesterase
A8O17_13540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8O17_13545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A8O17_13550	COG5401	PFAM Sporulation and spore germination
A8O17_13555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8O17_13560	COG1846	Transcriptional regulator
A8O17_13565	COG2197	response regulator
A8O17_13570	COG0824	Thioesterase
A8O17_13575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8O17_13580	COG1053	succinate dehydrogenase
A8O17_13585	COG2009	succinate dehydrogenase
A8O17_13595	COG1719	4-vinyl reductase, 4VR
A8O17_13600	COG0527	aspartate kinase activity
A8O17_13605	COG0322	excinuclease ABC activity
A8O17_13610	COG3118	belongs to the thioredoxin family
A8O17_13615	COG3534	alpha-L-arabinofuranosidase
A8O17_13620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A8O17_13625	COG2086	electron transfer activity
A8O17_13630	COG1024	Enoyl-CoA hydratase
A8O17_13635	COG1309	transcriptional regulator
A8O17_13640	COG0318	PFAM AMP-dependent synthetase and ligase
A8O17_13645	COG3766	membrane
A8O17_13650	COG1193	negative regulation of DNA recombination
A8O17_13655	COG1796	DNA polymerase
A8O17_13655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8O17_13660	COG1286	toxin biosynthetic process
A8O17_13665	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A8O17_13670	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8O17_13675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8O17_13675	COG0072	phenylalanine-tRNA ligase activity
A8O17_13680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8O17_13690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8O17_13700	COG3835	regulator
A8O17_13705	COG0277	FAD linked oxidase domain protein
A8O17_13710	COG0247	lactate metabolic process
A8O17_13715	COG0346	lactoylglutathione lyase activity
A8O17_13725	COG1966	Carbon starvation protein
A8O17_13730	COG3534	alpha-L-arabinofuranosidase
A8O17_13735	COG0395	ABC-type sugar transport system, permease component
A8O17_13740	COG1175	transmembrane transport
A8O17_13745	COG1653	transport
A8O17_13750	COG0371	Dehydrogenase
A8O17_13755	COG0647	UMP catabolic process
A8O17_13760	COG0235	Class ii aldolase
A8O17_13765	COG1069	ribulokinase activity
A8O17_13770	COG2160	L-arabinose isomerase activity
A8O17_13775	COG3507	Belongs to the glycosyl hydrolase 43 family
A8O17_13780	COG1363	Peptidase, m42
A8O17_13790	COG3326	Membrane
A8O17_13795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8O17_13800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8O17_13805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8O17_13815	COG1346	cytolysis
A8O17_13820	COG1380	Effector of murein hydrolase LrgA
A8O17_13825	COG3279	Response regulator of the LytR AlgR family
A8O17_13830	COG3275	phosphorelay sensor kinase activity
A8O17_13840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8O17_13850	COG0398	Pfam SNARE associated Golgi protein
A8O17_13855	COG1484	DNA-dependent DNA replication
A8O17_13860	COG3611	Membrane attachment protein
A8O17_13865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A8O17_13870	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A8O17_13875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8O17_13880	COG1733	regulation of RNA biosynthetic process
A8O17_13885	COG2814	Major facilitator Superfamily
A8O17_13890	COG0656	L-ascorbic acid biosynthetic process
A8O17_13895	COG0237	dephospho-CoA kinase activity
A8O17_13910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8O17_13915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8O17_13915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8O17_13920	COG5002	protein histidine kinase activity
A8O17_13925	COG0745	RESPONSE REGULATOR receiver
A8O17_13930	COG0039	L-malate dehydrogenase activity
A8O17_13935	COG0538	isocitrate dehydrogenase activity
A8O17_13940	COG0372	Belongs to the citrate synthase family
A8O17_13945	COG2707	UPF0756 membrane protein
A8O17_13950	COG0628	permease
A8O17_13955	COG3030	protein affecting phage T7 exclusion by the F plasmid
A8O17_13960	COG0469	pyruvate kinase activity
A8O17_13965	COG0205	6-phosphofructokinase activity
A8O17_13970	COG0825	malonyl-CoA metabolic process
A8O17_13975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A8O17_13980	COG0281	malic enzyme
A8O17_13985	COG0587	DNA-directed DNA polymerase activity
A8O17_14005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A8O17_14015	COG4109	DRTGG domain
A8O17_14025	COG0730	response to heat
A8O17_14030	COG1473	amidohydrolase
A8O17_14035	COG0196	riboflavin kinase activity
A8O17_14040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8O17_14045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A8O17_14050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8O17_14055	COG1126	abc transporter atp-binding protein
A8O17_14060	COG0765	amino acid transport
A8O17_14065	COG0765	amino acid transport
A8O17_14070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8O17_14075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8O17_14080	COG0454	-acetyltransferase
A8O17_14085	COG0583	DNA-binding transcription factor activity
A8O17_14090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A8O17_14095	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_14105	COG0165	Argininosuccinate lyase
A8O17_14110	COG0137	argininosuccinate synthase activity
A8O17_14115	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8O17_14120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8O17_14125	COG0827	DNA restriction-modification system
A8O17_14130	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A8O17_14135	COG3874	Sporulation protein YtfJ
A8O17_14145	COG1714	RDD family
A8O17_14150	COG0616	signal peptide processing
A8O17_14155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8O17_14160	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A8O17_14165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8O17_14175	COG0301	tRNA thio-modification
A8O17_14180	COG1104	cysteine desulfurase activity
A8O17_14185	COG1114	Component of the transport system for branched-chain amino acids
A8O17_14190	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A8O17_14195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8O17_14200	COG1309	transcriptional regulator
A8O17_14205	COG1956	GAF domain-containing protein
A8O17_14210	COG2199	diguanylate cyclase activity
A8O17_14210	COG2203	Gaf domain
A8O17_14215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A8O17_14225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8O17_14230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8O17_14235	COG0454	-acetyltransferase
A8O17_14240	COG0517	IMP dehydrogenase activity
A8O17_14245	COG0123	including yeast histone deacetylase and acetoin utilization protein
A8O17_14250	COG1360	Flagellar Motor Protein
A8O17_14255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A8O17_14260	COG1609	Transcriptional regulator
A8O17_14265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A8O17_14265	COG1605	Chorismate mutase
A8O17_14270	COG3118	belongs to the thioredoxin family
A8O17_14275	COG4980	gas vesicle protein
A8O17_14280	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A8O17_14285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8O17_14290	COG1674	ftsk spoiiie
A8O17_14295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8O17_14300	COG4848	Belongs to the UPF0354 family
A8O17_14305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8O17_14315	COG1363	Peptidase, m42
A8O17_14320	COG5584	Small secreted protein
A8O17_14325	COG0281	malic enzyme
A8O17_14330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8O17_14335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8O17_14345	COG0510	thiamine kinase activity
A8O17_14350	COG1523	belongs to the glycosyl hydrolase 13 family
A8O17_14355	COG1597	lipid kinase activity
A8O17_14365	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A8O17_14370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8O17_14375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8O17_14380	COG2252	PERMEase
A8O17_14385	COG4473	ABC transporter
A8O17_14390	COG1131	(ABC) transporter
A8O17_14395	COG1349	DNA-binding transcription factor activity
A8O17_14400	COG1187	pseudouridine synthase activity
A8O17_14405	COG2244	polysaccharide biosynthetic process
A8O17_14410	COG2081	HI0933 family
A8O17_14415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8O17_14425	COG5578	integral membrane protein
A8O17_14430	COG0673	inositol 2-dehydrogenase activity
A8O17_14435	COG1653	transport
A8O17_14440	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8O17_14445	COG4209	transmembrane transport
A8O17_14450	COG2207	Transcriptional regulator
A8O17_14455	COG1653	transport
A8O17_14460	COG0395	ABC-type sugar transport system, permease component
A8O17_14465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8O17_14470	COG2124	cytochrome p450
A8O17_14475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A8O17_14480	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A8O17_14485	COG0156	8-amino-7-oxononanoate synthase activity
A8O17_14490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8O17_14495	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
A8O17_14500	COG1073	alpha beta
A8O17_14525	COG1486	melibiose metabolic process
A8O17_14530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8O17_14535	COG0495	leucyl-tRNA aminoacylation
A8O17_14545	COG2202	Pas domain
A8O17_14545	COG1366	Belongs to the anti-sigma-factor antagonist family
A8O17_14550	COG2814	Major facilitator Superfamily
A8O17_14555	COG2433	Pfam Transposase IS66
A8O17_14560	COG0577	efflux transmembrane transporter activity
A8O17_14565	COG1136	(ABC) transporter
A8O17_14570	COG2205	protein histidine kinase activity
A8O17_14575	COG0745	RESPONSE REGULATOR receiver
A8O17_14580	COG0577	efflux transmembrane transporter activity
A8O17_14585	COG1136	(ABC) transporter
A8O17_14600	COG1131	(ABC) transporter
A8O17_14605	COG1725	Transcriptional regulator
A8O17_14620	COG1242	4 iron, 4 sulfur cluster binding
A8O17_14625	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A8O17_14635	COG2267	carboxylic ester hydrolase activity
A8O17_14640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A8O17_14645	COG1113	amino acid transport
A8O17_14650	COG0367	asparagine synthase
A8O17_14655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8O17_14660	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A8O17_14670	COG1506	peptidase
A8O17_14675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8O17_14680	COG1116	anion transmembrane transporter activity
A8O17_14685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8O17_14690	COG0494	nUDIX hydrolase
A8O17_14695	COG4824	toxin secretion phage lysis holin
A8O17_14700	COG0783	Belongs to the Dps family
A8O17_14715	COG1854	S-ribosylhomocysteine lyase activity
A8O17_14720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A8O17_14725	COG0288	reversible hydration of carbon dioxide
A8O17_14730	COG0254	rRNA binding
A8O17_14735	COG1271	oxidase subunit
A8O17_14740	COG1294	oxidase, subunit
A8O17_14750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8O17_14755	COG1321	iron dependent repressor
A8O17_14755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8O17_14760	COG1121	(ABC) transporter
A8O17_14765	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8O17_14770	COG4948	Mandelate Racemase Muconate Lactonizing
A8O17_14775	COG0318	PFAM AMP-dependent synthetase and ligase
A8O17_14780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A8O17_14785	COG0596	Alpha beta hydrolase
A8O17_14790	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A8O17_14795	COG1169	isochorismate synthase
A8O17_14800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8O17_14805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8O17_14810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8O17_14815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8O17_14820	COG0438	transferase activity, transferring glycosyl groups
A8O17_14830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8O17_14835	COG0438	transferase activity, transferring glycosyl groups
A8O17_14840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8O17_14845	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A8O17_14850	COG0058	SHG alpha-glucan phosphorylase activity
A8O17_14855	COG0297	glycogen (starch) synthase activity
A8O17_14860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8O17_14865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8O17_14870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8O17_15000	COG3859	Proton-coupled thiamine transporter YuaJ
A8O17_15005	COG1247	-acetyltransferase
A8O17_15010	COG2268	Band 7 protein
A8O17_15015	COG1585	Membrane protein implicated in regulation of membrane protease activity
A8O17_15020	COG2318	DinB family
A8O17_15030	COG1454	alcohol dehydrogenase
A8O17_15040	COG1510	regulation of RNA biosynthetic process
A8O17_15050	COG0569	domain protein
A8O17_15055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A8O17_15060	COG4682	membrane
A8O17_15065	COG1705	Flagellar rod assembly protein muramidase FlgJ
A8O17_15070	COG0477	Major facilitator Superfamily
A8O17_15075	COG5553	Cysteine dioxygenase type I
A8O17_15085	COG1968	undecaprenyl-diphosphatase activity
A8O17_15090	COG0628	permease
A8O17_15095	COG0673	inositol 2-dehydrogenase activity
A8O17_15100	COG4806	L-rhamnose isomerase
A8O17_15105	COG3254	rhamnose metabolic process
A8O17_15110	COG1070	Carbohydrate kinase
A8O17_15115	COG1349	DNA-binding transcription factor activity
A8O17_15120	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_15120	COG3347	Dehydrogenase
A8O17_15125	COG0840	transmembrane signaling receptor activity
A8O17_15130	COG0840	transmembrane signaling receptor activity
A8O17_15135	COG0840	transmembrane signaling receptor activity
A8O17_15140	COG0840	transmembrane signaling receptor activity
A8O17_15155	COG0432	Pfam Uncharacterised protein family UPF0047
A8O17_15160	COG0366	Alpha amylase catalytic
A8O17_15165	COG1253	flavin adenine dinucleotide binding
A8O17_15170	COG2738	Putative neutral zinc metallopeptidase
A8O17_15185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8O17_15200	COG0166	Belongs to the GPI family
A8O17_15205	COG1979	alcohol dehydrogenase
A8O17_15210	COG1979	alcohol dehydrogenase
A8O17_15215	COG2155	Conserved Protein
A8O17_15220	COG1098	S1 RNA binding domain
A8O17_15225	COG0436	Aminotransferase
A8O17_15230	COG1522	sequence-specific DNA binding
A8O17_15235	COG2267	carboxylic ester hydrolase activity
A8O17_15245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A8O17_15250	COG2205	protein histidine kinase activity
A8O17_15260	COG5018	Exonuclease
A8O17_15270	COG2814	Major facilitator Superfamily
A8O17_15275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8O17_15280	COG3011	Protein conserved in bacteria
A8O17_15290	COG3290	protein histidine kinase activity
A8O17_15295	COG4565	transcriptional regulatory protein
A8O17_15320	COG3493	citrate carrier protein
A8O17_15330	COG2111	Na H antiporter
A8O17_15330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8O17_15335	COG2111	Na H antiporter
A8O17_15340	COG1006	Multisubunit Na H antiporter MnhC subunit
A8O17_15345	COG0651	ATP synthesis coupled electron transport
A8O17_15350	COG1863	multisubunit Na H antiporter MnhE subunit
A8O17_15355	COG2212	antiporter activity
A8O17_15360	COG1320	monovalent cation:proton antiporter activity
A8O17_15365	COG2050	protein possibly involved in aromatic compounds catabolism
A8O17_15370	COG2197	response regulator
A8O17_15375	COG4585	Histidine kinase
A8O17_15385	COG0142	geranyltranstransferase activity
A8O17_15400	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A8O17_15405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8O17_15410	COG1335	isochorismatase
A8O17_15415	COG5506	Protein of unknown function (DUF1694)
A8O17_15430	COG0628	permease
A8O17_15445	COG1418	mRNA catabolic process
A8O17_15450	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_15460	COG1511	domain protein
A8O17_15465	COG0433	COG0433 Predicted ATPase
A8O17_15465	COG1674	ftsk spoiiie
A8O17_15470	COG4499	WXG100 protein secretion system (Wss), protein YukC
A8O17_15475	COG5417	Belongs to the EsaB family
A8O17_15480	COG4842	Belongs to the WXG100 family
A8O17_15485	COG2508	Transcriptional regulator
A8O17_15485	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A8O17_15490	COG0686	Belongs to the AlaDH PNT family
A8O17_15495	COG5634	Uncharacterized conserved protein (DUF2278)
A8O17_15500	COG3251	PFAM MbtH domain protein
A8O17_15505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_15510	COG3433	isochorismatase activity
A8O17_15510	COG1535	isochorismatase
A8O17_15515	COG1021	2,3-dihydroxybenzoate-AMP ligase
A8O17_15520	COG1169	isochorismate synthase
A8O17_15525	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_15530	COG2819	hydrolase of the alpha beta superfamily
A8O17_15535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8O17_15540	COG1268	BioY protein
A8O17_15545	COG2056	Na+-H+ antiporter family
A8O17_15550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A8O17_15555	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A8O17_15560	COG3584	3D domain protein
A8O17_15575	COG1252	NADH dehydrogenase
A8O17_15580	COG0492	ferredoxin-NADP+ reductase activity
A8O17_15590	COG0516	GMP reductase activity
A8O17_15595	COG2808	Putative FMN-binding domain
A8O17_15600	COG0456	acetyltransferase
A8O17_15605	COG0316	Belongs to the HesB IscA family
A8O17_15610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8O17_15615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8O17_15620	COG4844	belongs to the
A8O17_15625	COG1252	NADH dehydrogenase
A8O17_15630	COG4837	Protein of unknown function (DUF1462)
A8O17_15635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A8O17_15640	COG4946	Tricorn protease homolog
A8O17_15640	COG1506	peptidase
A8O17_15640	COG0823	Involved in the tonB-independent uptake of proteins
A8O17_15645	COG0083	homoserine kinase activity
A8O17_15650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A8O17_15655	COG0460	homoserine dehydrogenase
A8O17_15660	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8O17_15665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A8O17_15670	COG0647	UMP catabolic process
A8O17_15675	COG2445	Protein of unknown function DUF86
A8O17_15680	COG4470	Protein conserved in bacteria
A8O17_15690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8O17_15695	COG0739	heme binding
A8O17_15705	COG3377	Domain of unknown function (DUF1805)
A8O17_15710	COG0737	Belongs to the 5'-nucleotidase family
A8O17_15715	COG0730	response to heat
A8O17_15720	COG1801	Protein of unknown function DUF72
A8O17_15730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8O17_15735	COG2508	Transcriptional regulator
A8O17_15740	COG2233	PERMEase
A8O17_15745	COG2233	PERMEase
A8O17_15750	COG3195	allantoin biosynthetic process
A8O17_15750	COG3648	Uricase
A8O17_15755	COG2351	hydroxyisourate hydrolase activity
A8O17_15765	COG2080	2 iron, 2 sulfur cluster binding
A8O17_15770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8O17_15775	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A8O17_15780	COG2068	MobA-Related Protein
A8O17_15785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A8O17_15790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A8O17_15795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8O17_15805	COG2356	endonuclease I
A8O17_15810	COG3842	ATPase activity
A8O17_15815	COG2188	Transcriptional regulator
A8O17_15820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8O17_15825	COG0395	ABC-type sugar transport system, permease component
A8O17_15830	COG1175	transmembrane transport
A8O17_15835	COG1653	transport
A8O17_15840	COG2222	sugar isomerase
A8O17_15845	COG0322	excinuclease ABC activity
A8O17_15850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8O17_15865	COG0346	lactoylglutathione lyase activity
A8O17_15870	COG0640	Transcriptional regulator
A8O17_15875	COG0719	Fe-S assembly protein
A8O17_15880	COG0822	iron-sulfur transferase activity
A8O17_15885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8O17_15890	COG0719	Fe-S assembly protein
A8O17_15895	COG0396	ATPase activity
A8O17_15905	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8O17_15910	COG1464	Belongs to the NlpA lipoprotein family
A8O17_15915	COG2011	ABC-type metal ion transport system permease component
A8O17_15920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8O17_15930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8O17_15935	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A8O17_15945	COG0509	glycine decarboxylation via glycine cleavage system
A8O17_15950	COG1393	Belongs to the ArsC family
A8O17_15955	COG1960	acyl-CoA dehydrogenase activity
A8O17_15960	COG0183	Belongs to the thiolase family
A8O17_15965	COG1024	Enoyl-CoA hydratase
A8O17_15965	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8O17_15975	COG0506	proline dehydrogenase activity
A8O17_15985	COG5577	PFAM Coat F domain
A8O17_15990	COG1846	Transcriptional regulator
A8O17_15995	COG0477	Major facilitator Superfamily
A8O17_16000	COG1942	4-Oxalocrotonate Tautomerase
A8O17_16005	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_16010	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_16015	COG0583	DNA-binding transcription factor activity
A8O17_16025	COG1120	ATPase activity
A8O17_16045	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_16050	COG0783	Belongs to the Dps family
A8O17_16055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8O17_16060	COG0745	RESPONSE REGULATOR receiver
A8O17_16065	COG2205	protein histidine kinase activity
A8O17_16065	COG2770	Histidine kinase
A8O17_16075	COG1309	transcriptional regulator
A8O17_16080	COG0114	fumarate hydratase activity
A8O17_16090	COG0697	spore germination
A8O17_16095	COG0814	amino acid
A8O17_16105	COG2197	response regulator
A8O17_16110	COG4585	Histidine kinase
A8O17_16115	COG4758	membrane
A8O17_16120	COG3595	metallopeptidase activity
A8O17_16125	COG1842	Phage shock protein A
A8O17_16130	COG4758	membrane
A8O17_16135	COG2814	Major facilitator Superfamily
A8O17_16140	COG2096	Adenosyltransferase
A8O17_16145	COG1120	ATPase activity
A8O17_16150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_16155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8O17_16160	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_16165	COG3386	PFAM SMP-30 Gluconolaconase
A8O17_16170	COG2205	protein histidine kinase activity
A8O17_16175	COG0745	RESPONSE REGULATOR receiver
A8O17_16185	COG1191	sigma factor activity
A8O17_16195	COG2140	Oxalate decarboxylase
A8O17_16205	COG0577	efflux transmembrane transporter activity
A8O17_16210	COG1136	(ABC) transporter
A8O17_16215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8O17_16220	COG1120	ATPase activity
A8O17_16225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_16230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8O17_16235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8O17_16245	COG0531	amino acid
A8O17_16255	COG1988	membrane-bound metal-dependent
A8O17_16260	COG1368	sulfuric ester hydrolase activity
A8O17_16265	COG1910	domain protein
A8O17_16270	COG0725	ABC transporter, periplasmic molybdate-binding protein
A8O17_16275	COG4149	molybdate abc transporter
A8O17_16280	COG0656	L-ascorbic acid biosynthetic process
A8O17_16290	COG0025	NhaP-type Na H and K H
A8O17_16295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8O17_16300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A8O17_16305	COG3973	AAA domain
A8O17_16310	COG2860	membrane
A8O17_16315	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A8O17_16320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8O17_16325	COG2217	Heavy metal translocating P-type atpase
A8O17_16330	COG2217	Heavy metal translocating P-type atpase
A8O17_16335	COG2608	mercury ion transmembrane transporter activity
A8O17_16340	COG1937	Protein conserved in bacteria
A8O17_16345	COG0673	inositol 2-dehydrogenase activity
A8O17_16350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8O17_16355	COG1289	transmembrane transporter activity
A8O17_16365	COG2076	Multidrug Resistance protein
A8O17_16370	COG1309	transcriptional regulator
A8O17_16375	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_16385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A8O17_16390	COG0557	exoribonuclease II activity
A8O17_16395	COG1647	Serine aminopeptidase, S33
A8O17_16400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8O17_16405	COG0596	Alpha beta hydrolase
A8O17_16410	COG1476	TRANSCRIPTIONal
A8O17_16415	COG1396	sequence-specific DNA binding
A8O17_16420	COG1396	sequence-specific DNA binding
A8O17_16425	COG1733	regulation of RNA biosynthetic process
A8O17_16430	COG0840	transmembrane signaling receptor activity
A8O17_16435	COG1174	glycine betaine transport
A8O17_16440	COG1732	Glycine betaine
A8O17_16445	COG1174	glycine betaine transport
A8O17_16450	COG0517	IMP dehydrogenase activity
A8O17_16450	COG1125	glycine betaine transport
A8O17_16455	COG1510	regulation of RNA biosynthetic process
A8O17_16475	COG5658	integral membrane protein
A8O17_16480	COG0640	Transcriptional regulator
A8O17_16485	COG1174	glycine betaine transport
A8O17_16490	COG1732	Glycine betaine
A8O17_16495	COG1174	glycine betaine transport
A8O17_16500	COG1125	glycine betaine transport
A8O17_16500	COG0517	IMP dehydrogenase activity
A8O17_16505	COG1510	regulation of RNA biosynthetic process
A8O17_16510	COG2095	MarC family integral membrane protein
A8O17_16520	COG3064	Membrane
A8O17_16525	COG4640	response to antibiotic
A8O17_16530	COG0456	acetyltransferase
A8O17_16535	COG0148	phosphopyruvate hydratase activity
A8O17_16540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A8O17_16545	COG0149	triose-phosphate isomerase activity
A8O17_16550	COG0126	phosphoglycerate kinase activity
A8O17_16560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8O17_16565	COG2390	Transcriptional regulator
A8O17_16570	COG2814	Major facilitator Superfamily
A8O17_16575	COG1609	Transcriptional regulator
A8O17_16580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8O17_16585	COG0583	DNA-binding transcription factor activity
A8O17_16590	COG0697	spore germination
A8O17_16595	COG1113	amino acid transport
A8O17_16600	COG3858	chitin binding
A8O17_16605	COG1556	Lactate utilization protein
A8O17_16610	COG1139	Iron-sulfur cluster binding protein
A8O17_16615	COG0247	lactate metabolic process
A8O17_16620	COG2197	response regulator
A8O17_16625	COG4585	Histidine kinase
A8O17_16630	COG0842	Transport permease protein
A8O17_16635	COG1131	(ABC) transporter
A8O17_16640	COG0596	Alpha beta hydrolase
A8O17_16645	COG2208	phosphoserine phosphatase activity
A8O17_16650	COG3867	Arabinogalactan endo-beta-1,4-galactanase
A8O17_16655	COG1874	Beta-galactosidase
A8O17_16660	COG3833	ABC-type maltose transport systems, permease component
A8O17_16665	COG1175	transmembrane transport
A8O17_16670	COG2182	Extracellular solute-binding protein
A8O17_16675	COG1609	Transcriptional regulator
A8O17_16680	COG2186	Transcriptional regulator
A8O17_16685	COG1620	l-lactate permease
A8O17_16690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A8O17_16700	COG5039	Polysaccharide pyruvyl transferase
A8O17_16705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8O17_16710	COG0110	maltose O-acetyltransferase activity
A8O17_16715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8O17_16720	COG2244	polysaccharide biosynthetic process
A8O17_16725	COG1216	Glycosyl transferase, family 2
A8O17_16730	COG5039	Polysaccharide pyruvyl transferase
A8O17_16735	COG1216	Glycosyl transferase, family 2
A8O17_16745	COG0438	transferase activity, transferring glycosyl groups
A8O17_16750	COG1215	transferase activity, transferring glycosyl groups
A8O17_16755	COG0438	transferase activity, transferring glycosyl groups
A8O17_16760	COG1086	Polysaccharide biosynthesis protein
A8O17_16765	COG0489	protein tyrosine kinase activity
A8O17_16770	COG3944	biosynthesis protein
A8O17_16775	COG1396	sequence-specific DNA binding
A8O17_16780	COG2272	Belongs to the type-B carboxylesterase lipase family
A8O17_16790	COG3479	Phenolic acid decarboxylase
A8O17_16800	COG1794	racemase activity, acting on amino acids and derivatives
A8O17_16805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8O17_16810	COG1621	beta-fructofuranosidase activity
A8O17_16815	COG1621	beta-fructofuranosidase activity
A8O17_16820	COG0531	amino acid
A8O17_16825	COG1309	transcriptional regulator
A8O17_16830	COG2076	Multidrug Resistance protein
A8O17_16835	COG2076	Multidrug Resistance protein
A8O17_16845	COG0277	FAD linked oxidase domain protein
A8O17_16850	COG3621	Patatin-like phospholipase
A8O17_16860	COG0740	serine-type endopeptidase activity
A8O17_16865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8O17_16870	COG0366	Alpha amylase catalytic
A8O17_16875	COG1554	hydrolase, family 65, central catalytic
A8O17_16880	COG5521	maltodextrose utilization protein MalA
A8O17_16885	COG3833	ABC-type maltose transport systems, permease component
A8O17_16890	COG1175	transmembrane transport
A8O17_16895	COG2182	Extracellular solute-binding protein
A8O17_16900	COG0366	Alpha amylase catalytic
A8O17_16905	COG1609	Transcriptional regulator
A8O17_16910	COG1611	Belongs to the LOG family
A8O17_16915	COG1694	Mazg nucleotide pyrophosphohydrolase
A8O17_16920	COG0659	secondary active sulfate transmembrane transporter activity
A8O17_16925	COG0288	reversible hydration of carbon dioxide
A8O17_16930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8O17_16935	COG0577	efflux transmembrane transporter activity
A8O17_16940	COG1136	(ABC) transporter
A8O17_16945	COG5002	protein histidine kinase activity
A8O17_16950	COG0745	RESPONSE REGULATOR receiver
A8O17_16960	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A8O17_16965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8O17_16970	COG1481	regulation of sporulation
A8O17_16975	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A8O17_16980	COG1660	Displays ATPase and GTPase activities
A8O17_16985	COG1051	belongs to the nudix hydrolase family
A8O17_16990	COG0492	ferredoxin-NADP+ reductase activity
A8O17_16995	COG0791	NLP P60 protein
A8O17_16995	COG3883	PFAM NLP P60 protein
A8O17_17000	COG0457	Tetratricopeptide repeat
A8O17_17005	COG1132	(ABC) transporter
A8O17_17025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8O17_17025	COG0140	phosphoribosyl-ATP diphosphatase activity
A8O17_17030	COG0107	imidazoleglycerol-phosphate synthase activity
A8O17_17035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8O17_17040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A8O17_17045	COG0131	Imidazoleglycerol-phosphate dehydratase
A8O17_17050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8O17_17055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8O17_17060	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A8O17_17065	COG4990	cell redox homeostasis
A8O17_17070	COG5297	Belongs to the glycosyl hydrolase family 6
A8O17_17075	COG0110	maltose O-acetyltransferase activity
A8O17_17080	COG0546	phosphoglycolate phosphatase activity
A8O17_17085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A8O17_17090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8O17_17095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A8O17_17100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A8O17_17105	COG0363	glucosamine-6-phosphate deaminase activity
A8O17_17115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8O17_17120	COG1846	Transcriptional regulator
A8O17_17125	COG2124	cytochrome p450
A8O17_17135	COG1846	Transcriptional regulator
A8O17_17140	COG2814	Major facilitator Superfamily
A8O17_17145	COG1950	PFAM Membrane protein of
A8O17_17150	COG1983	PspC domain protein
A8O17_17155	COG3595	metallopeptidase activity
A8O17_17170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8O17_17175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8O17_17180	COG0556	nucleotide-excision repair
A8O17_17185	COG4897	Protein conserved in bacteria
A8O17_17190	COG0574	Belongs to the PEP-utilizing enzyme family
A8O17_17190	COG3848	Pyruvate phosphate dikinase
A8O17_17195	COG1309	transcriptional regulator
A8O17_17200	COG2814	Major facilitator Superfamily
A8O17_17205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8O17_17215	COG0793	Belongs to the peptidase S41A family
A8O17_17215	COG3409	Peptidoglycan-binding domain 1 protein
A8O17_17220	COG2177	Part of the ABC transporter FtsEX involved in
A8O17_17225	COG2884	Cell division ATP-binding protein ftsE
A8O17_17230	COG2010	Cytochrome c
A8O17_17235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8O17_17240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8O17_17245	COG0653	protein targeting
A8O17_17250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8O17_17265	COG1516	flagellar protein fliS
A8O17_17270	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A8O17_17275	COG1334	flagellar protein FlaG
A8O17_17280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8O17_17285	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A8O17_17290	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A8O17_17300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8O17_17305	COG4786	Flagellar basal body rod
A8O17_17305	COG1256	bacterial-type flagellum assembly
A8O17_17310	COG3418	PFAM FlgN family protein
A8O17_17315	COG2747	anti-sigma28 factor FlgM
A8O17_17325	COG1040	competence protein
A8O17_17335	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A8O17_17340	COG1307	EDD domain protein, DegV family
A8O17_17345	COG2197	response regulator
A8O17_17350	COG4585	Histidine kinase
A8O17_17355	COG1739	Uncharacterized protein family UPF0029
A8O17_17360	COG1316	TRANSCRIPTIONal
A8O17_17365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8O17_17370	COG0438	transferase activity, transferring glycosyl groups
A8O17_17375	COG1215	transferase activity, transferring glycosyl groups
A8O17_17380	COG3206	protein involved in exopolysaccharide biosynthesis
A8O17_17385	COG3307	-O-antigen
A8O17_17390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8O17_17395	COG0297	glycogen (starch) synthase activity
A8O17_17395	COG0438	transferase activity, transferring glycosyl groups
A8O17_17400	COG2244	polysaccharide biosynthetic process
A8O17_17405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8O17_17415	COG2247	cell wall binding repeat
A8O17_17415	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8O17_17420	COG2247	cell wall binding repeat
A8O17_17420	COG2385	sporulation resulting in formation of a cellular spore
A8O17_17430	COG1316	TRANSCRIPTIONal
A8O17_17435	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A8O17_17440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8O17_17445	COG1215	transferase activity, transferring glycosyl groups
A8O17_17445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8O17_17450	COG0463	Glycosyl transferase, family 2
A8O17_17465	COG1134	teichoic acid transport
A8O17_17470	COG1682	transport, permease protein
A8O17_17475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8O17_17480	COG0438	transferase activity, transferring glycosyl groups
A8O17_17485	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8O17_17490	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A8O17_17495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8O17_17505	COG4193	domain, Protein
A8O17_17510	COG1482	cell wall glycoprotein biosynthetic process
A8O17_17520	COG0697	spore germination
A8O17_17525	COG0814	amino acid
A8O17_17535	COG2814	Major facilitator Superfamily
A8O17_17540	COG1316	TRANSCRIPTIONal
A8O17_17545	COG0561	phosphatase activity
A8O17_17550	COG0791	NLP P60 protein
A8O17_17560	COG2843	Capsule synthesis protein
A8O17_17570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8O17_17575	COG1609	Transcriptional regulator
A8O17_17580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8O17_17585	COG1869	D-ribose catabolic process
A8O17_17590	COG1129	ABC transporter
A8O17_17595	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8O17_17600	COG1879	ABC-type sugar transport system periplasmic component
A8O17_17605	COG3103	Sh3 type 3 domain protein
A8O17_17615	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8O17_17620	COG3527	Alpha-acetolactate decarboxylase
A8O17_17625	COG0028	Belongs to the TPP enzyme family
A8O17_17630	COG0583	DNA-binding transcription factor activity
A8O17_17635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A8O17_17650	COG5337	Spore coat protein CotH
A8O17_17660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8O17_17670	COG0405	Gamma-glutamyltransferase
A8O17_17675	COG1522	sequence-specific DNA binding
A8O17_17680	COG2059	Chromate
A8O17_17685	COG2059	Chromate
A8O17_17695	COG0655	NAD(P)H dehydrogenase (quinone) activity
A8O17_17700	COG0583	DNA-binding transcription factor activity
A8O17_17705	COG1515	deoxyribonuclease V activity
A8O17_17710	COG2849	repeat protein
A8O17_17715	COG5444	nuclease activity
A8O17_17730	COG3878	Protein conserved in bacteria
A8O17_17735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8O17_17740	COG4464	protein tyrosine phosphatase activity
A8O17_17745	COG0489	protein tyrosine kinase activity
A8O17_17750	COG3944	biosynthesis protein
A8O17_17760	COG4715	Zinc finger, swim domain protein
A8O17_17765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8O17_17770	COG0561	phosphatase activity
A8O17_17775	COG1349	DNA-binding transcription factor activity
A8O17_17780	COG0629	single-stranded DNA binding
A8O17_17795	COG3764	Sortase (surface protein transpeptidase)
A8O17_17800	COG0745	RESPONSE REGULATOR receiver
A8O17_17800	COG2972	Histidine kinase
A8O17_17805	COG1970	mechanosensitive ion channel activity
A8O17_17810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8O17_17815	COG0457	Tetratricopeptide repeat
A8O17_17820	COG4786	Flagellar basal body rod
A8O17_17825	COG4786	Flagellar basal body rod
A8O17_17830	COG1077	Cell shape determining protein MreB Mrl
A8O17_17835	COG1609	Transcriptional regulator
A8O17_17840	COG1846	Transcriptional regulator
A8O17_17845	COG2814	Major facilitator Superfamily
A8O17_17850	COG3420	alginic acid biosynthetic process
A8O17_17855	COG1953	Uracil, thiamine, allantoin
A8O17_17860	COG0477	Major facilitator Superfamily
A8O17_17865	COG1335	isochorismatase
A8O17_17875	COG0004	ammonium transporteR
A8O17_17880	COG0347	Belongs to the P(II) protein family
A8O17_17885	COG0671	phosphoesterase, PA-phosphatase related
A8O17_17895	COG0739	heme binding
A8O17_17900	COG1247	-acetyltransferase
A8O17_17920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8O17_17925	COG0789	Transcriptional regulator
A8O17_17935	COG2910	NAD(P)H-binding
A8O17_17940	COG1959	2 iron, 2 sulfur cluster binding
A8O17_17945	COG0804	urea catabolic process
A8O17_17950	COG0832	Belongs to the urease beta subunit family
A8O17_17955	COG0831	urea catabolic process
A8O17_17965	COG3237	CsbD-like
A8O17_17970	COG1994	Peptidase M50
A8O17_17975	COG0457	Tetratricopeptide repeat
A8O17_17980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A8O17_17985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A8O17_17995	COG2304	oxidoreductase activity
A8O17_18005	COG2304	oxidoreductase activity
A8O17_18010	COG2385	sporulation resulting in formation of a cellular spore
A8O17_18015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8O17_18025	COG4836	Membrane
A8O17_18035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8O17_18040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A8O17_18045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8O17_18050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8O17_18055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8O17_18060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8O17_18070	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8O17_18075	COG0356	it plays a direct role in the translocation of protons across the membrane
A8O17_18085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8O17_18090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8O17_18095	COG4475	Protein of unknown function (DUF436)
A8O17_18100	COG0698	ribose 5-phosphate isomerase
A8O17_18105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8O17_18110	COG1971	Probably functions as a manganese efflux pump
A8O17_18115	COG0009	L-threonylcarbamoyladenylate synthase
A8O17_18120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A8O17_18140	COG2890	protein-(glutamine-N5) methyltransferase activity
A8O17_18145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8O17_18150	COG0346	lactoylglutathione lyase activity
A8O17_18155	COG0789	Transcriptional regulator
A8O17_18160	COG0679	Auxin Efflux Carrier
A8O17_18165	COG0281	malic enzyme
A8O17_18170	COG1435	thymidine kinase activity
A8O17_18175	COG0254	rRNA binding
A8O17_18180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8O17_18190	COG1494	fructose-1,6-bisphosphatase
A8O17_18195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8O17_18200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8O17_18205	COG0191	fructose-bisphosphate aldolase activity
A8O17_18210	COG2204	response regulator
A8O17_18215	COG4821	SIS domain
A8O17_18220	COG0504	CTP synthase activity
A8O17_18225	COG3343	RNA polymerase activity
A8O17_18230	COG1960	acyl-CoA dehydrogenase activity
A8O17_18235	COG2181	nitrate reductase activity
A8O17_18235	COG0247	lactate metabolic process
A8O17_18240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8O17_18245	COG4294	response to UV
A8O17_18255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8O17_18260	COG1132	(ABC) transporter
A8O17_18265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8O17_18275	COG2181	nitrate reductase activity
A8O17_18280	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A8O17_18285	COG1140	nitrate reductase beta subunit
A8O17_18290	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A8O17_18295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8O17_18305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8O17_18310	COG2223	nitrite transmembrane transporter activity
A8O17_18315	COG0018	arginyl-trna synthetase
A8O17_18320	COG4506	Protein conserved in bacteria
A8O17_18330	COG0535	radical SAM domain protein
A8O17_18340	COG1131	(ABC) transporter
A8O17_18345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A8O17_18350	COG0612	Peptidase, M16
A8O17_18355	COG0612	Peptidase, M16
A8O17_18365	COG3391	amine dehydrogenase activity
A8O17_18370	COG3391	amine dehydrogenase activity
A8O17_18380	COG0457	Tetratricopeptide repeat
A8O17_18390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8O17_18395	COG0010	Belongs to the arginase family
A8O17_18400	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A8O17_18405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8O17_18415	COG1994	Peptidase M50
A8O17_18420	COG1942	4-Oxalocrotonate Tautomerase
A8O17_18425	COG1846	Transcriptional regulator
A8O17_18430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8O17_18440	COG0477	Major facilitator Superfamily
A8O17_18445	COG1959	2 iron, 2 sulfur cluster binding
A8O17_18450	COG3465	dGTPase activity
A8O17_18455	COG1078	dGTPase activity
A8O17_18460	COG4844	belongs to the
A8O17_18470	COG0697	spore germination
A8O17_18475	COG0095	Lipoate-protein ligase
A8O17_18480	COG0583	DNA-binding transcription factor activity
A8O17_18485	COG0280	phosphate acetyltransferase
A8O17_18495	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_18500	COG0436	Aminotransferase
A8O17_18505	COG2814	Major facilitator Superfamily
A8O17_18510	COG0151	Belongs to the GarS family
A8O17_18515	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_18520	COG1917	Cupin 2, conserved barrel domain protein
A8O17_18525	COG0077	Prephenate dehydratase
A8O17_18530	COG2814	Major facilitator Superfamily
A8O17_18535	COG0833	amino acid
A8O17_18540	COG4187	Peptidase family M20/M25/M40
A8O17_18545	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_18550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8O17_18560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A8O17_18565	COG1091	dTDP-4-dehydrorhamnose reductase activity
A8O17_18570	COG1088	dTDP-glucose 4,6-dehydratase activity
A8O17_18575	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A8O17_18580	COG3980	spore coat polysaccharide biosynthesis protein
A8O17_18585	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
A8O17_18590	COG2089	acid synthase
A8O17_18595	COG0456	acetyltransferase
A8O17_18600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8O17_18605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8O17_18610	COG0463	Glycosyl transferase, family 2
A8O17_18625	COG2363	Small membrane protein
A8O17_18630	COG2233	PERMEase
A8O17_18640	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_18645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8O17_18650	COG1216	Glycosyl transferase, family 2
A8O17_18665	COG1695	Transcriptional regulator
A8O17_18670	COG0351	phosphomethylpyrimidine kinase
A8O17_18680	COG1621	beta-fructofuranosidase activity
A8O17_18685	COG1263	PTS System
A8O17_18685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_18690	COG2116	formate transmembrane transporter activity
A8O17_18695	COG3711	transcriptional antiterminator
A8O17_18705	COG1404	Belongs to the peptidase S8 family
A8O17_18710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8O17_18715	COG0778	Nitroreductase
A8O17_18720	COG0772	Belongs to the SEDS family
A8O17_18730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8O17_18735	COG1845	cytochrome c oxidase, subunit III
A8O17_18740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8O17_18745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8O17_18750	COG2261	transglycosylase associated protein
A8O17_18755	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A8O17_18760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A8O17_18765	COG2246	polysaccharide biosynthetic process
A8O17_18770	COG1309	transcriptional regulator
A8O17_18780	COG3162	membrane
A8O17_18785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8O17_18790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8O17_18795	COG2837	iron assimilation
A8O17_18800	COG2822	iron ion transport
A8O17_18805	COG0672	)-iron permease
A8O17_18810	COG0352	thiamine-phosphate diphosphorylase activity
A8O17_18815	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A8O17_18820	COG0583	DNA-binding transcription factor activity
A8O17_18825	COG1380	Effector of murein hydrolase LrgA
A8O17_18830	COG1346	cytolysis
A8O17_18835	COG2814	Major facilitator Superfamily
A8O17_18840	COG4895	conserved protein (DUF2196)
A8O17_18845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A8O17_18850	COG0346	lactoylglutathione lyase activity
A8O17_18860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8O17_18865	COG1404	Belongs to the peptidase S8 family
A8O17_18870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_18870	COG1263	PTS System
A8O17_18875	COG3711	transcriptional antiterminator
A8O17_18880	COG1442	glycosyl transferase family 8
A8O17_18885	COG5522	Integral membrane protein (intg_mem_TP0381)
A8O17_18890	COG1846	Transcriptional regulator
A8O17_18895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8O17_18900	COG2234	aminopeptidase activity
A8O17_18905	COG2357	RelA SpoT domain protein
A8O17_18910	COG1575	Belongs to the MenA family. Type 1 subfamily
A8O17_18925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8O17_18930	COG1696	Membrane protein involved in D-alanine export
A8O17_18935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8O17_18940	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A8O17_18945	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A8O17_18950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8O17_18955	COG1486	melibiose metabolic process
A8O17_18960	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8O17_18965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8O17_18970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8O17_18975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8O17_18975	COG3711	transcriptional antiterminator
A8O17_18985	COG2094	Belongs to the DNA glycosylase MPG family
A8O17_18990	COG0753	catalase activity
A8O17_18995	COG2814	Major facilitator Superfamily
A8O17_19000	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8O17_19005	COG1131	(ABC) transporter
A8O17_19025	COG1595	DNA-templated transcription, initiation
A8O17_19030	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A8O17_19035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A8O17_19040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A8O17_19045	COG4988	ABC transporter
A8O17_19050	COG1294	oxidase, subunit
A8O17_19055	COG1271	oxidase subunit
A8O17_19060	COG3493	citrate carrier protein
A8O17_19065	COG0501	Belongs to the peptidase M48B family
A8O17_19075	COG0726	polysaccharide deacetylase
A8O17_19080	COG3842	ATPase activity
A8O17_19085	COG2508	Transcriptional regulator
A8O17_19090	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_19095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8O17_19105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8O17_19110	COG1881	PFAM PEBP family protein
A8O17_19115	COG0583	DNA-binding transcription factor activity
A8O17_19125	COG4585	Histidine kinase
A8O17_19130	COG2197	response regulator
A8O17_19135	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8O17_19150	COG4894	glucomannan catabolic process
A8O17_19155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8O17_19160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8O17_19165	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_19170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8O17_19175	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A8O17_19180	COG2610	gluconate transmembrane transporter activity
A8O17_19190	COG0500	methyltransferase
A8O17_19195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8O17_19215	COG0753	catalase activity
A8O17_19215	COG0693	protein deglycase activity
A8O17_19220	COG2851	Citrate transporter
A8O17_19225	COG2273	Hydrolase Family 16
A8O17_19230	COG3711	transcriptional antiterminator
A8O17_19240	COG2270	Major facilitator Superfamily
A8O17_19245	COG0513	Belongs to the DEAD box helicase family
A8O17_19250	COG3401	FG-GAP repeat protein
A8O17_19250	COG2755	lipolytic protein G-D-S-L family
A8O17_19305	COG3209	COG3209 Rhs family protein
A8O17_19310	COG0697	spore germination
A8O17_19315	COG0589	response to stress
A8O17_19320	COG2723	6-phospho-beta-galactosidase activity
A8O17_19325	COG2190	(PTS) system
A8O17_19325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8O17_19325	COG1263	PTS System
A8O17_19340	COG5444	nuclease activity
A8O17_19355	COG3507	Belongs to the glycosyl hydrolase 43 family
A8O17_19370	COG2986	histidine ammonia-lyase
A8O17_19375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A8O17_19380	COG1228	amidohydrolase
A8O17_19385	COG0010	Belongs to the arginase family
A8O17_19390	COG0833	amino acid
A8O17_19395	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A8O17_19400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8O17_19405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A8O17_19410	COG2390	Transcriptional regulator
A8O17_19420	COG3192	ethanolamine utilization protein
A8O17_19425	COG2079	MmgE PrpD family protein
A8O17_19435	COG1126	abc transporter atp-binding protein
A8O17_19440	COG0765	amino acid transport
A8O17_19445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8O17_19465	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A8O17_19470	COG0561	phosphatase activity
A8O17_19500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8O17_19505	COG5294	Protein conserved in bacteria
A8O17_19510	COG0577	efflux transmembrane transporter activity
A8O17_19515	COG1136	(ABC) transporter
A8O17_19520	COG2205	protein histidine kinase activity
A8O17_19525	COG0745	RESPONSE REGULATOR receiver
A8O17_19530	COG0191	fructose-bisphosphate aldolase activity
A8O17_19535	COG1082	Xylose isomerase domain protein TIM barrel
A8O17_19540	COG1082	Xylose isomerase domain protein TIM barrel
A8O17_19545	COG0673	inositol 2-dehydrogenase activity
A8O17_19550	COG2814	Major facilitator Superfamily
A8O17_19555	COG1082	Xylose isomerase domain protein TIM barrel
A8O17_19560	COG3962	Belongs to the TPP enzyme family
A8O17_19565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8O17_19570	COG3718	enzyme involved in inositol metabolism
A8O17_19575	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_19580	COG1349	DNA-binding transcription factor activity
A8O17_19585	COG0667	Aldo Keto reductase
A8O17_19600	COG2814	Major facilitator Superfamily
A8O17_19605	COG0326	Molecular chaperone. Has ATPase activity
A8O17_19615	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_19620	COG1309	transcriptional regulator
A8O17_19625	COG1012	belongs to the aldehyde dehydrogenase family
A8O17_19630	COG0456	acetyltransferase
A8O17_19635	COG2850	peptidyl-arginine hydroxylation
A8O17_19640	COG2226	methyltransferase
A8O17_19655	COG0367	asparagine synthase
A8O17_19660	COG2814	Major facilitator Superfamily
A8O17_19665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8O17_19675	COG1714	RDD family
A8O17_19680	COG2311	Membrane
A8O17_19685	COG1917	Cupin 2, conserved barrel domain protein
A8O17_19690	COG1309	transcriptional regulator
A8O17_19695	COG1028	Short-chain dehydrogenase reductase Sdr
A8O17_19700	COG1846	Transcriptional regulator
A8O17_19705	COG1380	Effector of murein hydrolase LrgA
A8O17_19710	COG1346	cytolysis
A8O17_19715	COG5039	Polysaccharide pyruvyl transferase
A8O17_19720	COG1929	Belongs to the glycerate kinase type-1 family
A8O17_19725	COG1802	Transcriptional regulator
A8O17_19730	COG1070	Carbohydrate kinase
A8O17_19735	COG2610	gluconate transmembrane transporter activity
A8O17_19740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8O17_19745	COG0450	alkyl hydroperoxide reductase
A8O17_19750	COG3634	alkyl hydroperoxide reductase activity
A8O17_19755	COG2723	6-phospho-beta-galactosidase activity
A8O17_19760	COG2190	(PTS) system
A8O17_19765	COG2188	Transcriptional regulator
A8O17_19780	COG1131	(ABC) transporter
A8O17_19785	COG1994	Peptidase M50
A8O17_19790	COG0535	radical SAM domain protein
A8O17_19800	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A8O17_19805	COG5293	efflux transmembrane transporter activity
A8O17_19815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8O17_19820	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A8O17_19835	COG1063	alcohol dehydrogenase
A8O17_19855	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
A8O17_19860	COG0456	acetyltransferase
A8O17_19865	COG0457	Tetratricopeptide repeat
A8O17_19875	COG0010	Belongs to the arginase family
A8O17_19880	COG0833	amino acid
A8O17_19885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8O17_19890	COG3829	transcription factor binding
A8O17_19895	COG5002	protein histidine kinase activity
A8O17_19905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8O17_19910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A8O17_19915	COG4853	Protein conserved in bacteria
A8O17_19920	COG4863	YycH protein
A8O17_19925	COG5002	protein histidine kinase activity
A8O17_19930	COG0745	RESPONSE REGULATOR receiver
A8O17_19960	COG0346	lactoylglutathione lyase activity
A8O17_19965	COG0305	Participates in initiation and elongation during chromosome replication
A8O17_19985	COG3093	addiction module antidote protein HigA
A8O17_19990	COG2807	transmembrane transport
A8O17_19995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8O17_20000	COG0359	binds to the 23S rRNA
A8O17_20005	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A8O17_20010	COG4241	membrane
A8O17_20020	COG5577	PFAM Coat F domain
A8O17_20025	COG1733	regulation of RNA biosynthetic process
A8O17_20030	COG1227	inorganic diphosphatase activity
A8O17_20045	COG2271	Major facilitator Superfamily
A8O17_20055	COG4319	ketosteroid isomerase
A8O17_20085	COG1131	(ABC) transporter
A8O17_20095	COG4319	ketosteroid isomerase
A8O17_20100	COG1357	PFAM Pentapeptide repeats (8 copies)
A8O17_20105	COG2814	Major facilitator Superfamily
A8O17_20110	COG0583	DNA-binding transcription factor activity
A8O17_20115	COG2153	protein acetylation
A8O17_20125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8O17_20130	COG1846	Transcriptional regulator
A8O17_20135	COG2153	protein acetylation
A8O17_20140	COG2364	Membrane
A8O17_20145	COG0456	acetyltransferase
A8O17_20150	COG2315	Protein conserved in bacteria
A8O17_20155	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8O17_20160	COG2814	Major facilitator Superfamily
A8O17_20165	COG1331	Highly conserved protein containing a thioredoxin domain
A8O17_20170	COG0789	Transcriptional regulator
A8O17_20175	COG0697	spore germination
A8O17_20180	COG1331	Highly conserved protein containing a thioredoxin domain
A8O17_20185	COG1266	CAAX protease self-immunity
A8O17_20190	COG2814	Major facilitator Superfamily
A8O17_20190	COG0477	Major facilitator Superfamily
A8O17_20195	COG0110	maltose O-acetyltransferase activity
A8O17_20200	COG0346	lactoylglutathione lyase activity
A8O17_20205	COG1609	Transcriptional regulator
A8O17_20210	COG0708	Exodeoxyribonuclease III
A8O17_20215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8O17_20220	COG0629	single-stranded DNA binding
A8O17_20225	COG0360	Binds together with S18 to 16S ribosomal RNA
A8O17_20230	COG0012	GTP binding
A8O17_20235	COG0243	molybdopterin cofactor binding
A8O17_20240	COG4481	Protein conserved in bacteria
A8O17_20245	COG3949	Membrane
A8O17_20255	COG1475	DNA binding
A8O17_20260	COG1192	Involved in chromosome partitioning
A8O17_20270	COG1475	DNA binding
A8O17_20275	COG0357	Ribosomal RNA small subunit methyltransferase G
A8O17_20280	COG0445	tRNA wobble uridine modification
A8O17_20285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8O17_20290	COG1847	R3H domain protein
A8O17_20295	COG0706	membrane insertase activity
A8O17_20300	COG0594	ribonuclease P activity
A8O17_20305	COG0230	Belongs to the bacterial ribosomal protein bL34 family