locus-tag	class	description
K4756_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K4756_00010	COG0592	DNA-directed DNA polymerase activity
K4756_00015	COG2501	S4 domain
K4756_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K4756_00030	COG0187	DNA topoisomerase II activity
K4756_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K4756_00070	COG0516	GMP reductase activity
K4756_00070	COG0517	IMP dehydrogenase activity
K4756_00075	COG1686	Belongs to the peptidase S11 family
K4756_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K4756_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K4756_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K4756_00100	COG1428	Deoxynucleoside kinase
K4756_00105	COG1428	Deoxynucleoside kinase
K4756_00110	COG1388	LysM domain
K4756_00110	COG3858	chitin binding
K4756_00115	COG1335	isochorismatase
K4756_00120	COG0590	tRNA wobble adenosine to inosine editing
K4756_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K4756_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K4756_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
K4756_00190	COG3853	Toxic anion resistance protein (TelA)
K4756_00195	COG1982	Orn Lys Arg decarboxylase major
K4756_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K4756_00205	COG3870	Protein conserved in bacteria
K4756_00210	COG1728	Protein conserved in bacteria
K4756_00215	COG0470	DNA polymerase III
K4756_00220	COG1774	PSP1 C-terminal conserved region
K4756_00225	COG4467	Involved in initiation control of chromosome replication
K4756_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K4756_00235	COG2827	Endonuclease containing a URI domain
K4756_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K4756_00245	COG2002	toxin-antitoxin pair type II binding
K4756_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4756_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4756_00255	COG0084	hydrolase, TatD family'
K4756_00260	COG3583	domain protein
K4756_00260	COG3584	3D domain protein
K4756_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K4756_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K4756_00280	COG4466	Protein conserved in bacteria
K4756_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K4756_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K4756_00300	COG0251	oxidation-reduction process
K4756_00305	COG2088	sporulation resulting in formation of a cellular spore
K4756_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K4756_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K4756_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K4756_00325	COG0193	aminoacyl-tRNA hydrolase activity
K4756_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K4756_00340	COG2002	toxin-antitoxin pair type II binding
K4756_00345	COG2244	polysaccharide biosynthetic process
K4756_00350	COG3956	TIGRFAM MazG family protein
K4756_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K4756_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K4756_00375	COG1098	S1 RNA binding domain
K4756_00390	COG2208	phosphoserine phosphatase activity
K4756_00395	COG2304	oxidoreductase activity
K4756_00400	COG0515	serine threonine protein kinase
K4756_00405	COG0037	tRNA processing
K4756_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K4756_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K4756_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K4756_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K4756_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K4756_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K4756_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K4756_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
K4756_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K4756_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K4756_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K4756_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K4756_00470	COG1396	sequence-specific DNA binding
K4756_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K4756_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K4756_00560	COG4463	regulation of RNA biosynthetic process
K4756_00565	COG3880	PFAM UvrB UvrC protein
K4756_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
K4756_00575	COG0542	response to heat
K4756_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K4756_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K4756_00590	COG4956	integral membrane protein (PIN domain superfamily)
K4756_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K4756_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K4756_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K4756_00610	COG1045	serine acetyltransferase
K4756_00615	COG0215	cysteine-tRNA ligase activity
K4756_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K4756_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K4756_00630	COG3688	RNA-binding protein containing a PIN domain
K4756_00635	COG1595	DNA-templated transcription, initiation
K4756_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K4756_00650	COG0250	Participates in transcription elongation, termination and antitermination
K4756_00660	COG0081	regulation of translation
K4756_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K4756_00675	COG2813	Specifically methylates the guanine in position
K4756_00680	COG0085	RNA polymerase activity
K4756_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K4756_00690	COG1358	cellular component organization or biogenesis
K4756_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K4756_00700	COG0049	tRNA binding
K4756_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K4756_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K4756_00715	COG0596	Alpha beta hydrolase
K4756_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K4756_00730	COG0088	Forms part of the polypeptide exit tunnel
K4756_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K4756_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K4756_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K4756_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K4756_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K4756_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K4756_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K4756_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K4756_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K4756_00820	COG0200	Binds to the 23S rRNA
K4756_00825	COG0201	protein transport
K4756_00830	COG0563	adenylate kinase activity
K4756_00835	COG0024	Methionine aminopeptidase
K4756_00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K4756_00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K4756_00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K4756_00860	COG0202	RNA polymerase activity
K4756_00865	COG0203	ribosomal protein L17
K4756_00870	COG1122	ATPase activity
K4756_00875	COG1122	ATPase activity
K4756_00880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K4756_00885	COG0101	tRNA pseudouridine synthase activity
K4756_00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K4756_00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K4756_00900	COG2226	methyltransferase
K4756_00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4756_00915	COG0489	protein tyrosine kinase activity
K4756_00925	COG2194	sulfuric ester hydrolase activity
K4756_00930	COG0726	polysaccharide deacetylase
K4756_01010	COG0659	secondary active sulfate transmembrane transporter activity
K4756_01015	COG0385	Bile acid
K4756_01020	COG2819	hydrolase of the alpha beta superfamily
K4756_01025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_01035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4756_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4756_01040	COG2207	Transcriptional regulator
K4756_01045	COG3876	Protein conserved in bacteria
K4756_01050	COG1472	Belongs to the glycosyl hydrolase 3 family
K4756_01055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K4756_01060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_01060	COG1263	PTS System
K4756_01065	COG1737	Transcriptional regulator
K4756_01070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K4756_01075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4756_01080	COG1683	Conserved Protein
K4756_01110	COG1595	DNA-templated transcription, initiation
K4756_01115	COG5662	AntiSigma factor
K4756_01120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K4756_01125	COG4856	YbbR-like protein
K4756_01130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K4756_01135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K4756_01145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K4756_01150	COG3002	Belongs to the UPF0753 family
K4756_01155	COG0288	reversible hydration of carbon dioxide
K4756_01165	COG5609	conserved protein (DUF2294)
K4756_01170	COG0640	Transcriptional regulator
K4756_01175	COG2814	Major facilitator Superfamily
K4756_01190	COG0596	Alpha beta hydrolase
K4756_01195	COG0745	RESPONSE REGULATOR receiver
K4756_01200	COG0642	Histidine kinase
K4756_01210	COG0515	serine threonine protein kinase
K4756_01225	COG1113	amino acid transport
K4756_01240	COG2602	Beta-lactamase
K4756_01245	COG2124	cytochrome p450
K4756_01255	COG0531	amino acid
K4756_01260	COG0584	glycerophosphoryl diester phosphodiesterase
K4756_01265	COG2271	Major facilitator Superfamily
K4756_01275	COG0456	acetyltransferase
K4756_01275	COG1846	Transcriptional regulator
K4756_01280	COG2271	Major facilitator Superfamily
K4756_01290	COG0697	spore germination
K4756_01295	COG1917	Cupin 2, conserved barrel domain protein
K4756_01295	COG2207	Transcriptional regulator
K4756_01300	COG1397	ADP-ribosylglycohydrolase
K4756_01305	COG5444	nuclease activity
K4756_01310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K4756_01315	COG3591	Belongs to the peptidase S1B family
K4756_01325	COG0596	Alpha beta hydrolase
K4756_01330	COG1183	phosphatidylcholine synthase activity
K4756_01335	COG0586	Pfam SNARE associated Golgi protein
K4756_01340	COG0688	phosphatidylethanolamine metabolic process
K4756_01350	COG2312	Erythromycin esterase
K4756_01355	COG1054	Belongs to the UPF0176 family
K4756_01360	COG1301	dicarboxylic acid transport
K4756_01365	COG2190	(PTS) system
K4756_01365	COG1263	PTS System
K4756_01365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_01370	COG0363	glucosamine-6-phosphate deaminase activity
K4756_01375	COG2188	Transcriptional regulator
K4756_01385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K4756_01390	COG0833	amino acid
K4756_01395	COG2040	homocysteine
K4756_01400	COG1115	amino acid carrier protein
K4756_01405	COG2066	Belongs to the glutaminase family
K4756_01410	COG4191	Histidine kinase
K4756_01415	COG0784	Response regulator, receiver
K4756_01420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K4756_01425	COG1012	belongs to the aldehyde dehydrogenase family
K4756_01430	COG2271	Major facilitator Superfamily
K4756_01435	COG4948	Mandelate Racemase Muconate Lactonizing
K4756_01440	COG2186	Transcriptional regulator
K4756_01445	COG2721	sulfolactate sulfo-lyase activity
K4756_01450	COG3173	Aminoglycoside phosphotransferase
K4756_01460	COG0697	spore germination
K4756_01465	COG0745	RESPONSE REGULATOR receiver
K4756_01470	COG2205	protein histidine kinase activity
K4756_01475	COG1131	(ABC) transporter
K4756_01495	COG3773	Cell wall hydrolase
K4756_01500	COG2304	oxidoreductase activity
K4756_01510	COG3540	Alkaline phosphatase
K4756_01515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K4756_01520	COG0805	protein transport
K4756_01525	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K4756_01530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K4756_01535	COG0477	Major facilitator Superfamily
K4756_01540	COG1309	transcriptional regulator
K4756_01545	COG0252	asparaginase activity
K4756_01550	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K4756_01555	COG1714	RDD family
K4756_01560	COG1405	negative regulation of cell septum assembly
K4756_01560	COG3012	SEC-C Motif Domain Protein
K4756_01565	COG3290	protein histidine kinase activity
K4756_01570	COG3279	Response regulator of the LytR AlgR family
K4756_01575	COG4555	ABC transporter
K4756_01580	COG1668	transmembrane transport
K4756_01585	COG0667	Aldo Keto reductase
K4756_01600	COG1595	DNA-templated transcription, initiation
K4756_01605	COG1595	DNA-templated transcription, initiation
K4756_01610	COG1876	peptidase activity
K4756_01615	COG0457	Tetratricopeptide repeat
K4756_01620	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_01625	COG0366	Alpha amylase catalytic
K4756_01630	COG0803	Belongs to the bacterial solute-binding protein 9 family
K4756_01635	COG1121	(ABC) transporter
K4756_01640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K4756_01645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4756_01650	COG2310	stress, protein
K4756_01655	COG2310	stress, protein
K4756_01660	COG2310	stress, protein
K4756_01665	COG0861	Integral membrane protein TerC family
K4756_01675	COG3853	Toxic anion resistance protein (TelA)
K4756_01680	COG0477	Major facilitator Superfamily
K4756_01685	COG2814	Major facilitator Superfamily
K4756_01690	COG0640	Transcriptional regulator
K4756_01695	COG0517	IMP dehydrogenase activity
K4756_01695	COG4175	Glycine betaine
K4756_01700	COG4176	ABC-type proline glycine betaine transport system permease component
K4756_01705	COG2113	Glycine betaine
K4756_01710	COG1473	amidohydrolase
K4756_01715	COG1288	antiporter activity
K4756_01725	COG0366	Alpha amylase catalytic
K4756_01730	COG0039	L-malate dehydrogenase activity
K4756_01735	COG1620	l-lactate permease
K4756_01740	COG2814	Major facilitator Superfamily
K4756_01745	COG1846	Transcriptional regulator
K4756_01750	COG1280	lysine exporter protein (LysE YggA)
K4756_01755	COG3403	YqcI/YcgG family
K4756_01760	COG1113	amino acid transport
K4756_01765	COG3665	Urea carboxylase-associated protein
K4756_01770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K4756_01775	COG1660	Displays ATPase and GTPase activities
K4756_01780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K4756_01785	COG2226	methyltransferase
K4756_01790	COG0583	DNA-binding transcription factor activity
K4756_01795	COG3458	cephalosporin-C deacetylase activity
K4756_01800	COG3541	Predicted nucleotidyltransferase
K4756_01805	COG0506	proline dehydrogenase activity
K4756_01810	COG1012	belongs to the aldehyde dehydrogenase family
K4756_01815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4756_01820	COG2508	Transcriptional regulator
K4756_01825	COG3689	TIGRFAM TIGR03943 family protein
K4756_01830	COG0701	Predicted permease
K4756_01835	COG2267	carboxylic ester hydrolase activity
K4756_01840	COG0492	ferredoxin-NADP+ reductase activity
K4756_01845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K4756_01845	COG1587	Uroporphyrinogen-III synthase
K4756_01850	COG2146	nitrite reductase [NAD(P)H] activity
K4756_01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K4756_01860	COG0243	molybdopterin cofactor binding
K4756_01865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K4756_01870	COG2223	nitrite transmembrane transporter activity
K4756_01875	COG1469	GTP cyclohydrolase I activity
K4756_01880	COG1376	ErfK ybiS ycfS ynhG family protein
K4756_01890	COG0523	cobalamin synthesis protein
K4756_01895	COG0765	amino acid transport
K4756_01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4756_01920	COG2723	6-phospho-beta-galactosidase activity
K4756_01930	COG3209	COG3209 Rhs family protein
K4756_01935	COG0840	transmembrane signaling receptor activity
K4756_01935	COG3290	protein histidine kinase activity
K4756_01940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K4756_01945	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K4756_01950	COG1733	regulation of RNA biosynthetic process
K4756_01955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_01960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_01970	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
K4756_01975	COG2814	Major facilitator Superfamily
K4756_01985	COG0697	spore germination
K4756_01990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4756_02000	COG2364	Membrane
K4756_02005	COG1126	abc transporter atp-binding protein
K4756_02010	COG0765	amino acid transport
K4756_02015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4756_02020	COG0583	DNA-binding transcription factor activity
K4756_02025	COG0163	prenyltransferase activity
K4756_02030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K4756_02045	COG0596	Alpha beta hydrolase
K4756_02050	COG3104	oligopeptide transport
K4756_02055	COG5434	Belongs to the glycosyl hydrolase 28 family
K4756_02065	COG0697	spore germination
K4756_02075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K4756_02080	COG1136	(ABC) transporter
K4756_02085	COG0577	efflux transmembrane transporter activity
K4756_02090	COG0745	RESPONSE REGULATOR receiver
K4756_02095	COG3850	Histidine kinase
K4756_02095	COG5002	protein histidine kinase activity
K4756_02100	COG0457	Tetratricopeptide repeat
K4756_02120	COG0527	aspartate kinase activity
K4756_02125	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_02130	COG4605	iron ion homeostasis
K4756_02135	COG4604	ABC transporter, ATP-binding protein
K4756_02140	COG4607	ABC-type enterochelin transport system periplasmic component
K4756_02145	COG2814	Major facilitator Superfamily
K4756_02150	COG1309	transcriptional regulator
K4756_02155	COG0778	Nitroreductase
K4756_02160	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K4756_02165	COG0640	Transcriptional regulator
K4756_02170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4756_02175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K4756_02180	COG1012	belongs to the aldehyde dehydrogenase family
K4756_02185	COG4975	Glucose uptake
K4756_02190	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_02195	COG4549	nuclear export factor GLE1
K4756_02200	COG2372	response to copper ion
K4756_02200	COG1276	copper resistance
K4756_02205	COG1349	DNA-binding transcription factor activity
K4756_02215	COG2213	PTS system mannitol-specific
K4756_02220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4756_02225	COG0246	Mannitol dehydrogenase
K4756_02230	COG0473	3-isopropylmalate dehydrogenase activity
K4756_02235	COG0681	Belongs to the peptidase S26 family
K4756_02240	COG0412	Dienelactone hydrolase
K4756_02245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K4756_02255	COG0561	phosphatase activity
K4756_02260	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K4756_02265	COG1914	H( )-stimulated, divalent metal cation uptake system
K4756_02270	COG4336	lyase activity
K4756_02275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K4756_02280	COG1984	allophanate hydrolase subunit 2
K4756_02285	COG1414	Transcriptional regulator
K4756_02290	COG2755	lipolytic protein G-D-S-L family
K4756_02300	COG2329	Antibiotic biosynthesis monooxygenase
K4756_02305	COG0768	penicillin binding
K4756_02310	COG4989	oxidoreductase activity
K4756_02315	COG3711	transcriptional antiterminator
K4756_02320	COG0318	PFAM AMP-dependent synthetase and ligase
K4756_02325	COG2226	methyltransferase
K4756_02330	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_02335	COG1917	Cupin 2, conserved barrel domain protein
K4756_02340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4756_02345	COG3871	stress protein (general stress protein 26)
K4756_02355	COG2814	Major facilitator Superfamily
K4756_02360	COG1522	sequence-specific DNA binding
K4756_02365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K4756_02365	COG0551	DNA topoisomerase type I activity
K4756_02370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K4756_02375	COG3706	GGDEF domain
K4756_02380	COG5298	Protein conserved in bacteria
K4756_02385	COG1215	transferase activity, transferring glycosyl groups
K4756_02395	COG0531	amino acid
K4756_02400	COG0494	nUDIX hydrolase
K4756_02405	COG0028	Belongs to the TPP enzyme family
K4756_02420	COG1914	H( )-stimulated, divalent metal cation uptake system
K4756_02425	COG2261	transglycosylase associated protein
K4756_02430	COG4876	unkown
K4756_02435	COG2217	Heavy metal translocating P-type atpase
K4756_02440	COG3729	General stress protein
K4756_02445	COG0662	Cupin 2, conserved barrel domain protein
K4756_02450	COG2329	Antibiotic biosynthesis monooxygenase
K4756_02455	COG3546	catalase activity
K4756_02460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K4756_02465	COG3290	protein histidine kinase activity
K4756_02470	COG4565	transcriptional regulatory protein
K4756_02475	COG1301	dicarboxylic acid transport
K4756_02480	COG0628	permease
K4756_02485	COG1131	(ABC) transporter
K4756_02490	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K4756_02500	COG1960	acyl-CoA dehydrogenase activity
K4756_02515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K4756_02520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4756_02525	COG1181	Belongs to the D-alanine--D-alanine ligase family
K4756_02530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K4756_02535	COG0513	Belongs to the DEAD box helicase family
K4756_02540	COG3402	PFAM membrane-flanked domain
K4756_02545	COG3428	Bacterial PH domain
K4756_02550	COG0705	Rhomboid family
K4756_02555	COG0736	holo-[acyl-carrier-protein] synthase activity
K4756_02560	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K4756_02565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K4756_02570	COG0864	Transcriptional regulator
K4756_02575	COG2337	Toxic component of a toxin-antitoxin (TA) module
K4756_02580	COG1366	Belongs to the anti-sigma-factor antagonist family
K4756_02585	COG1366	Belongs to the anti-sigma-factor antagonist family
K4756_02590	COG2172	sigma factor antagonist activity
K4756_02595	COG2208	phosphoserine phosphatase activity
K4756_02600	COG1366	Belongs to the anti-sigma-factor antagonist family
K4756_02605	COG2172	sigma factor antagonist activity
K4756_02610	COG1191	sigma factor activity
K4756_02615	COG2208	phosphoserine phosphatase activity
K4756_02625	COG1673	EVE domain
K4756_02630	COG1846	Transcriptional regulator
K4756_02635	COG2183	response to ionizing radiation
K4756_02645	COG3091	SprT-like family
K4756_02700	COG0515	serine threonine protein kinase
K4756_02735	COG1132	(ABC) transporter
K4756_02750	COG1476	TRANSCRIPTIONal
K4756_02760	COG3239	Fatty acid desaturase
K4756_02770	COG1278	Cold shock
K4756_02775	COG1329	Transcriptional regulator
K4756_02780	COG2207	Transcriptional regulator
K4756_02780	COG1917	Cupin 2, conserved barrel domain protein
K4756_02785	COG0697	spore germination
K4756_02790	COG3708	Transcriptional regulator
K4756_02790	COG2207	Transcriptional regulator
K4756_02795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4756_02800	COG0477	Major facilitator Superfamily
K4756_02810	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
K4756_02820	COG0697	spore germination
K4756_02825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4756_02830	COG2030	dehydratase
K4756_02835	COG3545	Serine hydrolase
K4756_02840	COG1733	regulation of RNA biosynthetic process
K4756_02845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4756_02850	COG1733	regulation of RNA biosynthetic process
K4756_02855	COG2249	NAD(P)H dehydrogenase (quinone) activity
K4756_02860	COG2814	Major facilitator Superfamily
K4756_02865	COG1309	transcriptional regulator
K4756_02870	COG0640	Transcriptional regulator
K4756_02875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K4756_02885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4756_02890	COG1316	TRANSCRIPTIONal
K4756_02905	COG5002	protein histidine kinase activity
K4756_02910	COG0745	RESPONSE REGULATOR receiver
K4756_02915	COG0697	spore germination
K4756_02920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4756_02925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K4756_02930	COG0640	Transcriptional regulator
K4756_02935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K4756_02950	COG4585	Histidine kinase
K4756_02955	COG2197	response regulator
K4756_02960	COG2409	Drug exporters of the RND superfamily
K4756_02965	COG0596	Alpha beta hydrolase
K4756_02970	COG1811	Na channel or pump
K4756_02975	COG0789	Transcriptional regulator
K4756_02975	COG4978	Transcriptional regulator
K4756_02980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K4756_02985	COG0778	Nitroreductase
K4756_02990	COG0346	lactoylglutathione lyase activity
K4756_02995	COG2259	Doxx family
K4756_03000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4756_03020	COG2323	membrane
K4756_03030	COG0071	Belongs to the small heat shock protein (HSP20) family
K4756_03045	COG1309	transcriptional regulator
K4756_03055	COG0456	acetyltransferase
K4756_03065	COG2814	Major facilitator Superfamily
K4756_03075	COG0488	(ABC) transporter
K4756_03080	COG1113	amino acid transport
K4756_03085	COG2318	DinB family
K4756_03090	COG1846	Transcriptional regulator
K4756_03095	COG1033	growth of symbiont in host cell
K4756_03095	COG2409	Drug exporters of the RND superfamily
K4756_03100	COG0778	Nitroreductase
K4756_03105	COG1846	Transcriptional regulator
K4756_03110	COG2814	Major facilitator Superfamily
K4756_03115	COG0730	response to heat
K4756_03120	COG1802	Transcriptional regulator
K4756_03125	COG1388	LysM domain
K4756_03125	COG3858	chitin binding
K4756_03130	COG1819	glycosyl
K4756_03140	COG1785	Belongs to the alkaline phosphatase family
K4756_03145	COG5646	InterPro IPR014922
K4756_03155	COG0454	-acetyltransferase
K4756_03160	COG1078	dGTPase activity
K4756_03165	COG1388	LysM domain
K4756_03170	COG2814	Major facilitator Superfamily
K4756_03175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4756_03180	COG1447	Phosphotransferase system cellobiose-specific component IIA
K4756_03185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4756_03190	COG2723	6-phospho-beta-galactosidase activity
K4756_03195	COG2188	Transcriptional regulator
K4756_03200	COG1940	carbohydrate kinase activity
K4756_03205	COG1482	cell wall glycoprotein biosynthetic process
K4756_03210	COG4124	Belongs to the glycosyl hydrolase 26 family
K4756_03255	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K4756_03260	COG0802	atpase or kinase
K4756_03265	COG1214	PFAM Peptidase M22, glycoprotease
K4756_03270	COG0456	acetyltransferase
K4756_03275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K4756_03280	COG0488	(ABC) transporter
K4756_03285	COG0315	cyclic pyranopterin monophosphate synthase activity
K4756_03290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K4756_03295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K4756_03300	COG0805	protein transport
K4756_03310	COG1266	CAAX protease self-immunity
K4756_03320	COG0459	protein refolding
K4756_03325	COG1073	alpha beta
K4756_03330	COG0457	Tetratricopeptide repeat
K4756_03335	COG1063	alcohol dehydrogenase
K4756_03340	COG2211	Major facilitator Superfamily
K4756_03345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4756_03350	COG1842	Phage shock protein A
K4756_03355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K4756_03360	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K4756_03365	COG4260	virion core protein, lumpy skin disease virus
K4756_03375	COG2814	Major facilitator Superfamily
K4756_03380	COG1063	alcohol dehydrogenase
K4756_03385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K4756_03390	COG0823	Involved in the tonB-independent uptake of proteins
K4756_03405	COG2267	carboxylic ester hydrolase activity
K4756_03415	COG2132	Multicopper oxidase
K4756_03420	COG1113	amino acid transport
K4756_03430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K4756_03435	COG0714	Associated with various cellular activities
K4756_03440	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
K4756_03445	COG1305	Transglutaminase-like
K4756_03450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K4756_03450	COG0519	Catalyzes the synthesis of GMP from XMP
K4756_03465	COG2252	PERMEase
K4756_03470	COG3064	Membrane
K4756_03480	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K4756_03490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K4756_03495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K4756_03500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K4756_03505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K4756_03510	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K4756_03515	COG0047	phosphoribosylformylglycinamidine synthase activity
K4756_03520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K4756_03525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K4756_03530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K4756_03535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K4756_03540	COG0138	bifunctional purine biosynthesis protein purh
K4756_03545	COG0151	Belongs to the GarS family
K4756_03550	COG1522	sequence-specific DNA binding
K4756_03555	COG0531	amino acid
K4756_03565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K4756_03570	COG1470	cell adhesion involved in biofilm formation
K4756_03575	COG4496	protein, YerC YecD
K4756_03580	COG0069	glutamate synthase activity
K4756_03585	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
K4756_03590	COG0210	DNA helicase
K4756_03595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K4756_03600	COG4851	CamS sex pheromone cAM373 precursor
K4756_03605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K4756_03610	COG1285	pathogenesis
K4756_03615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4756_03620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K4756_03625	COG0154	amidase activity
K4756_03630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K4756_03635	COG1309	transcriptional regulator
K4756_03640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K4756_03645	COG1597	lipid kinase activity
K4756_03650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K4756_03655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K4756_03660	COG5293	efflux transmembrane transporter activity
K4756_03705	COG5444	nuclease activity
K4756_03715	COG3586	endonuclease activity
K4756_03725	COG0457	Tetratricopeptide repeat
K4756_03735	COG0217	transcriptional regulatory protein
K4756_03745	COG1309	transcriptional regulator
K4756_03750	COG3631	Ketosteroid isomerase-related protein
K4756_03755	COG0702	epimerase
K4756_03770	COG3546	catalase activity
K4756_03775	COG0454	-acetyltransferase
K4756_03785	COG5578	integral membrane protein
K4756_03790	COG2972	Histidine kinase
K4756_03795	COG2207	Transcriptional regulator
K4756_03795	COG4753	response regulator
K4756_03800	COG1653	transport
K4756_03805	COG1175	transmembrane transport
K4756_03810	COG0395	ABC-type sugar transport system, permease component
K4756_03815	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K4756_03820	COG2207	Transcriptional regulator
K4756_03825	COG2755	lipolytic protein G-D-S-L family
K4756_03835	COG5578	integral membrane protein
K4756_03840	COG3401	FG-GAP repeat protein
K4756_03845	COG3401	FG-GAP repeat protein
K4756_03850	COG2755	lipolytic protein G-D-S-L family
K4756_03855	COG1874	Beta-galactosidase
K4756_03865	COG1653	transport
K4756_03870	COG4209	transmembrane transport
K4756_03875	COG0395	ABC-type sugar transport system, permease component
K4756_03880	COG1486	melibiose metabolic process
K4756_03885	COG2323	membrane
K4756_03890	COG2329	Antibiotic biosynthesis monooxygenase
K4756_03895	COG0346	lactoylglutathione lyase activity
K4756_03910	COG5583	Uncharacterized small protein (DUF2292)
K4756_03915	COG0670	Belongs to the BI1 family
K4756_03930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K4756_03930	COG2124	cytochrome p450
K4756_03935	COG1368	sulfuric ester hydrolase activity
K4756_03940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K4756_03945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4756_03950	COG1442	glycosyl transferase family 8
K4756_03955	COG1216	Glycosyl transferase, family 2
K4756_03960	COG1442	glycosyl transferase family 8
K4756_03965	COG2223	nitrite transmembrane transporter activity
K4756_03970	COG1011	Hydrolase
K4756_03975	COG0531	amino acid
K4756_03980	COG1012	belongs to the aldehyde dehydrogenase family
K4756_03985	COG0840	transmembrane signaling receptor activity
K4756_03990	COG0488	(ABC) transporter
K4756_04000	COG0789	Transcriptional regulator
K4756_04005	COG2814	Major facilitator Superfamily
K4756_04020	COG0488	(ABC) transporter
K4756_04025	COG0513	Belongs to the DEAD box helicase family
K4756_04030	COG0456	acetyltransferase
K4756_04035	COG2130	NADP-dependent
K4756_04040	COG1120	ATPase activity
K4756_04045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_04050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_04055	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K4756_04070	COG3866	Pectate lyase
K4756_04075	COG0471	metal ion transport
K4756_04080	COG3290	protein histidine kinase activity
K4756_04085	COG4565	transcriptional regulatory protein
K4756_04090	COG3181	Tripartite tricarboxylate transporter family receptor
K4756_04095	COG2851	Citrate transporter
K4756_04100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4756_04105	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K4756_04110	COG1254	Belongs to the acylphosphatase family
K4756_04115	COG2258	MOSC domain
K4756_04135	COG0024	Methionine aminopeptidase
K4756_04140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_04140	COG1263	PTS System
K4756_04145	COG1368	sulfuric ester hydrolase activity
K4756_04160	COG1115	amino acid carrier protein
K4756_04165	COG0531	amino acid
K4756_04180	COG0697	spore germination
K4756_04185	COG1263	PTS System
K4756_04185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_04190	COG0366	Alpha amylase catalytic
K4756_04195	COG2188	Transcriptional regulator
K4756_04200	COG0778	Nitroreductase
K4756_04205	COG0737	Belongs to the 5'-nucleotidase family
K4756_04210	COG0693	protein deglycase activity
K4756_04215	COG2814	Major facilitator Superfamily
K4756_04220	COG4840	Belongs to the UPF0435 family
K4756_04225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K4756_04230	COG4980	gas vesicle protein
K4756_04235	COG1295	ribonuclease BN
K4756_04240	COG0477	Major facilitator Superfamily
K4756_04245	COG0387	Pfam Sodium calcium exchanger
K4756_04255	COG0668	transmembrane transport
K4756_04260	COG0535	radical SAM domain protein
K4756_04270	COG0726	polysaccharide deacetylase
K4756_04275	COG2084	Dehydrogenase
K4756_04280	COG0598	Magnesium transport protein CorA
K4756_04285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K4756_04290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K4756_04300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K4756_04305	COG4637	Psort location Cytoplasmic, score
K4756_04315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K4756_04320	COG0022	dehydrogenase e1 component
K4756_04325	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4756_04330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4756_04335	COG3284	Transcriptional regulator
K4756_04345	COG1742	UPF0060 membrane protein
K4756_04365	COG4842	Belongs to the WXG100 family
K4756_04370	COG1486	melibiose metabolic process
K4756_04375	COG1737	Transcriptional regulator
K4756_04380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_04380	COG1263	PTS System
K4756_04385	COG1132	(ABC) transporter
K4756_04390	COG1132	(ABC) transporter
K4756_04395	COG2259	Doxx family
K4756_04400	COG2514	catechol 2,3-dioxygenase activity
K4756_04405	COG4585	Histidine kinase
K4756_04410	COG2197	response regulator
K4756_04415	COG1131	(ABC) transporter
K4756_04420	COG1511	domain protein
K4756_04420	COG0842	Transport permease protein
K4756_04425	COG0842	Transport permease protein
K4756_04435	COG1695	Transcriptional regulator
K4756_04440	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K4756_04460	COG1131	(ABC) transporter
K4756_04465	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
K4756_04470	COG1309	transcriptional regulator
K4756_04475	COG2814	Major facilitator Superfamily
K4756_04480	COG2318	DinB family
K4756_04485	COG2814	Major facilitator Superfamily
K4756_04490	COG1846	Transcriptional regulator
K4756_04495	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K4756_04495	COG0392	lysyltransferase activity
K4756_04500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4756_04505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_04510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_04515	COG0384	phenazine biosynthesis protein PhzF
K4756_04520	COG0778	Nitroreductase
K4756_04535	COG1090	epimerase
K4756_04540	COG2137	regulation of response to DNA damage stimulus
K4756_04550	COG2814	Major facilitator Superfamily
K4756_04565	COG3103	Sh3 type 3 domain protein
K4756_04570	COG5658	integral membrane protein
K4756_04575	COG0596	Alpha beta hydrolase
K4756_04580	COG0463	Glycosyl transferase, family 2
K4756_04585	COG4485	Bacterial membrane protein, YfhO
K4756_04590	COG1988	membrane-bound metal-dependent
K4756_04595	COG1194	a g-specific adenine glycosylase
K4756_04605	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_04620	COG3557	Belongs to the UPF0374 family
K4756_04625	COG1132	(ABC) transporter
K4756_04630	COG4129	membrane
K4756_04635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K4756_04640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K4756_04645	COG0735	belongs to the Fur family
K4756_04755	COG4326	sporulation control protein
K4756_04765	COG5577	PFAM Coat F domain
K4756_04770	COG3340	Belongs to the peptidase S51 family
K4756_04775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K4756_04790	COG0753	catalase activity
K4756_04795	COG1116	anion transmembrane transporter activity
K4756_04800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K4756_04805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K4756_04810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4756_04820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K4756_04830	COG1476	TRANSCRIPTIONal
K4756_04840	COG3382	B3 4 domain protein
K4756_04845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K4756_04855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K4756_04860	COG0789	Transcriptional regulator
K4756_04865	COG1664	Polymer-forming cytoskeletal
K4756_04870	COG1664	Polymer-forming cytoskeletal
K4756_04875	COG2766	serine protein kinase
K4756_04880	COG2718	Belongs to the UPF0229 family
K4756_04885	COG1846	Transcriptional regulator
K4756_04890	COG1566	PFAM secretion protein HlyD family protein
K4756_04895	COG2814	Major facilitator Superfamily
K4756_04900	COG0655	NAD(P)H dehydrogenase (quinone) activity
K4756_04920	COG1725	Transcriptional regulator
K4756_04925	COG1131	(ABC) transporter
K4756_04930	COG1131	(ABC) transporter
K4756_04935	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K4756_04940	COG1278	Cold shock
K4756_04945	COG1464	Belongs to the NlpA lipoprotein family
K4756_04955	COG1823	symporter activity
K4756_04975	COG5577	PFAM Coat F domain
K4756_04980	COG1525	nuclease
K4756_04980	COG4085	toxin activity
K4756_04980	COG0737	Belongs to the 5'-nucleotidase family
K4756_04985	COG3764	Sortase (surface protein transpeptidase)
K4756_04990	COG0564	pseudouridine synthase activity
K4756_05000	COG0517	IMP dehydrogenase activity
K4756_05005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K4756_05010	COG3153	acetyltransferase
K4756_05010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K4756_05015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K4756_05020	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K4756_05025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K4756_05030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K4756_05035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K4756_05040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K4756_05045	COG4585	Histidine kinase
K4756_05045	COG2203	Gaf domain
K4756_05050	COG2197	response regulator
K4756_05055	COG0431	NADPH-dependent FMN reductase
K4756_05070	COG1388	LysM domain
K4756_05070	COG0791	NLP P60 protein
K4756_05075	COG1959	2 iron, 2 sulfur cluster binding
K4756_05085	COG0668	transmembrane transport
K4756_05090	COG2719	SpoVR family
K4756_05095	COG1785	Belongs to the alkaline phosphatase family
K4756_05100	COG1388	LysM domain
K4756_05100	COG0791	NLP P60 protein
K4756_05105	COG0583	DNA-binding transcription factor activity
K4756_05110	COG0372	Belongs to the citrate synthase family
K4756_05115	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_05120	COG0531	amino acid
K4756_05125	COG0733	neurotransmitter:sodium symporter activity
K4756_05135	COG0456	acetyltransferase
K4756_05150	COG1595	DNA-templated transcription, initiation
K4756_05155	COG0667	Aldo Keto reductase
K4756_05160	COG0204	Acyl-transferase
K4756_05165	COG1253	flavin adenine dinucleotide binding
K4756_05170	COG0789	Transcriptional regulator
K4756_05175	COG0436	Aminotransferase
K4756_05180	COG1253	flavin adenine dinucleotide binding
K4756_05185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K4756_05190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K4756_05195	COG0584	glycerophosphoryl diester phosphodiesterase
K4756_05205	COG0668	transmembrane transport
K4756_05210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K4756_05215	COG0726	polysaccharide deacetylase
K4756_05220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K4756_05225	COG1757	Na H antiporter
K4756_05230	COG0589	response to stress
K4756_05240	COG1132	(ABC) transporter
K4756_05245	COG1132	(ABC) transporter
K4756_05250	COG0702	epimerase
K4756_05270	COG0189	ligase activity
K4756_05275	COG0189	ligase activity
K4756_05280	COG4399	Belongs to the UPF0754 family
K4756_05285	COG3679	Belongs to the UPF0342 family
K4756_05290	COG4335	DNA alkylation repair
K4756_05295	COG0561	phosphatase activity
K4756_05300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K4756_05305	COG0475	glutathione-regulated potassium exporter activity
K4756_05310	COG0490	domain, Protein
K4756_05320	COG1024	Enoyl-CoA hydratase
K4756_05330	COG4152	abc transporter atp-binding protein
K4756_05335	COG1668	transmembrane transport
K4756_05340	COG0420	3'-5' exonuclease activity
K4756_05345	COG4717	serine-type aminopeptidase activity
K4756_05350	COG3481	metal-dependent phosphohydrolase, HD sub domain
K4756_05360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K4756_05390	COG1846	Transcriptional regulator
K4756_05395	COG4980	gas vesicle protein
K4756_05410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K4756_05415	COG0537	adenosine 5'-monophosphoramidase activity
K4756_05420	COG1131	(ABC) transporter
K4756_05425	COG4473	ABC transporter
K4756_05435	COG1473	amidohydrolase
K4756_05440	COG3069	C4-dicarboxylate transmembrane transporter activity
K4756_05450	COG2329	Antibiotic biosynthesis monooxygenase
K4756_05455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4756_05460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K4756_05465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K4756_05470	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K4756_05475	COG1309	transcriptional regulator
K4756_05480	COG1511	domain protein
K4756_05485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K4756_05490	COG4377	Putative membrane peptidase family (DUF2324)
K4756_05500	COG1363	Peptidase, m42
K4756_05505	COG4405	Protein conserved in bacteria
K4756_05510	COG1301	dicarboxylic acid transport
K4756_05520	COG1234	tRNA 3'-trailer cleavage
K4756_05525	COG0095	Lipoate-protein ligase
K4756_05530	COG0702	epimerase
K4756_05535	COG0318	PFAM AMP-dependent synthetase and ligase
K4756_05545	COG0501	Belongs to the peptidase M48B family
K4756_05550	COG1404	Belongs to the peptidase S8 family
K4756_05560	COG0604	alcohol dehydrogenase
K4756_05565	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K4756_05570	COG0406	alpha-ribazole phosphatase activity
K4756_05575	COG0183	Belongs to the thiolase family
K4756_05580	COG0318	PFAM AMP-dependent synthetase and ligase
K4756_05585	COG1268	BioY protein
K4756_05590	COG0840	transmembrane signaling receptor activity
K4756_05595	COG0723	plastoquinol--plastocyanin reductase activity
K4756_05595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4756_05600	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_05610	COG4903	ComK protein
K4756_05615	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_05625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4756_05640	COG0398	Pfam SNARE associated Golgi protein
K4756_05645	COG0681	Belongs to the peptidase S26 family
K4756_05650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K4756_05655	COG1846	Transcriptional regulator
K4756_05660	COG0738	Major facilitator superfamily
K4756_05665	COG0673	inositol 2-dehydrogenase activity
K4756_05670	COG0561	phosphatase activity
K4756_05675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K4756_05680	COG1609	Transcriptional regulator
K4756_05685	COG3180	Ammonia monooxygenase
K4756_05690	COG2814	Major facilitator Superfamily
K4756_05690	COG0477	Major facilitator Superfamily
K4756_05695	COG4533	DNA binding
K4756_05705	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K4756_05710	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K4756_05715	COG1074	ATP-dependent DNA helicase activity
K4756_05720	COG0420	3'-5' exonuclease activity
K4756_05725	COG0419	ATPase involved in DNA repair
K4756_05730	COG1403	HNH endonuclease
K4756_05770	COG5337	Spore coat protein CotH
K4756_05775	COG0179	Fumarylacetoacetate (FAA) hydrolase
K4756_05785	COG1404	Belongs to the peptidase S8 family
K4756_05795	COG0367	asparagine synthase
K4756_05800	COG1562	ergosterol biosynthetic process
K4756_05805	COG0534	Mate efflux family protein
K4756_05810	COG2207	Transcriptional regulator
K4756_05810	COG1917	Cupin 2, conserved barrel domain protein
K4756_05815	COG1609	Transcriptional regulator
K4756_05820	COG0673	inositol 2-dehydrogenase activity
K4756_05825	COG2318	DinB family
K4756_05830	COG1279	arginine transmembrane transporter activity
K4756_05835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4756_05840	COG1357	PFAM Pentapeptide repeats (8 copies)
K4756_05845	COG2267	carboxylic ester hydrolase activity
K4756_05850	COG0529	Catalyzes the synthesis of activated sulfate
K4756_05855	COG2046	Belongs to the sulfate adenylyltransferase family
K4756_05860	COG0175	sulfate reduction
K4756_05865	COG2045	Belongs to the ComB family
K4756_05870	COG1809	phosphosulfolactate synthase activity
K4756_05875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4756_05880	COG4948	Mandelate Racemase Muconate Lactonizing
K4756_05885	COG2814	Major facilitator Superfamily
K4756_05890	COG0454	-acetyltransferase
K4756_05895	COG2153	protein acetylation
K4756_05900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K4756_05900	COG0646	methionine synthase
K4756_05910	COG2996	Protein conserved in bacteria
K4756_05930	COG1695	Transcriptional regulator
K4756_05945	COG3227	Zinc metalloprotease (Elastase)
K4756_05950	COG1307	EDD domain protein, DegV family
K4756_05955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4756_05975	COG0561	phosphatase activity
K4756_05980	COG1073	alpha beta
K4756_05985	COG2151	metal-sulfur cluster biosynthetic enzyme
K4756_05995	COG0277	FAD linked oxidase domain protein
K4756_06000	COG2271	Major facilitator Superfamily
K4756_06005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K4756_06010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K4756_06020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K4756_06025	COG0505	Belongs to the CarA family
K4756_06030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K4756_06035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K4756_06050	COG2267	carboxylic ester hydrolase activity
K4756_06060	COG1744	ABC transporter substrate-binding protein PnrA-like
K4756_06075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K4756_06080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K4756_06085	COG5504	Zn-dependent protease
K4756_06090	COG0444	Belongs to the ABC transporter superfamily
K4756_06095	COG4608	Belongs to the ABC transporter superfamily
K4756_06105	COG0601	transmembrane transport
K4756_06110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K4756_06120	COG0180	Tryptophanyl-tRNA synthetase
K4756_06125	COG4166	transmembrane transport
K4756_06130	COG0601	transmembrane transport
K4756_06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K4756_06140	COG0444	Belongs to the ABC transporter superfamily
K4756_06145	COG4608	Belongs to the ABC transporter superfamily
K4756_06150	COG2814	Major facilitator Superfamily
K4756_06155	COG0456	acetyltransferase
K4756_06160	COG1393	Belongs to the ArsC family
K4756_06165	COG0861	Integral membrane protein TerC family
K4756_06175	COG4862	establishment of competence for transformation
K4756_06185	COG4469	Competence protein
K4756_06190	COG1164	Oligoendopeptidase f
K4756_06200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K4756_06205	COG2346	COG2346, Truncated hemoglobins
K4756_06210	COG0741	lytic transglycosylase activity
K4756_06215	COG4116	CYTH
K4756_06225	COG2357	RelA SpoT domain protein
K4756_06230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K4756_06235	COG0564	pseudouridine synthase activity
K4756_06240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K4756_06245	COG0475	glutathione-regulated potassium exporter activity
K4756_06245	COG0569	domain protein
K4756_06250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K4756_06255	COG0352	thiamine-phosphate diphosphorylase activity
K4756_06260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4756_06265	COG2104	thiamine diphosphate biosynthetic process
K4756_06270	COG2022	thiamine diphosphate biosynthetic process
K4756_06275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K4756_06280	COG0351	phosphomethylpyrimidine kinase
K4756_06285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K4756_06340	COG0210	DNA helicase
K4756_06350	COG2153	protein acetylation
K4756_06355	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K4756_06360	COG2382	esterase
K4756_06365	COG0626	cystathionine gamma-synthase activity
K4756_06370	COG0626	cystathionine gamma-synthase activity
K4756_06375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4756_06380	COG5505	Protein of unknown function (DUF819)
K4756_06430	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K4756_06440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4756_06440	COG3711	transcriptional antiterminator
K4756_06445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4756_06445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4756_06445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4756_06450	COG1482	cell wall glycoprotein biosynthetic process
K4756_06460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4756_06470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K4756_06485	COG0109	protoheme IX farnesyltransferase activity
K4756_06495	COG0726	polysaccharide deacetylase
K4756_06510	COG5504	Zn-dependent protease
K4756_06515	COG2205	protein histidine kinase activity
K4756_06525	COG3383	formate dehydrogenase (NAD+) activity
K4756_06530	COG2427	Protein of unknown function (DUF1641)
K4756_06550	COG2124	cytochrome p450
K4756_06555	COG1819	glycosyl
K4756_06565	COG1587	Uroporphyrinogen-III synthase
K4756_06570	COG0390	transport system, permease component
K4756_06575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K4756_06580	COG0697	spore germination
K4756_06585	COG4297	protein containing double-stranded beta helix domain
K4756_06595	COG1252	NADH dehydrogenase
K4756_06600	COG1904	glucuronate isomerase
K4756_06605	COG2211	Major facilitator Superfamily
K4756_06610	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K4756_06615	COG1063	alcohol dehydrogenase
K4756_06620	COG1312	Catalyzes the dehydration of D-mannonate
K4756_06625	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_06630	COG2271	Major facilitator Superfamily
K4756_06635	COG1609	Transcriptional regulator
K4756_06640	COG0246	Mannitol dehydrogenase
K4756_06645	COG2721	sulfolactate sulfo-lyase activity
K4756_06650	COG0730	response to heat
K4756_06655	COG2318	DinB family
K4756_06660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K4756_06665	COG0457	Tetratricopeptide repeat
K4756_06675	COG2350	Protein conserved in bacteria
K4756_06680	COG1388	LysM domain
K4756_06680	COG3409	Peptidoglycan-binding domain 1 protein
K4756_06680	COG5632	N-Acetylmuramoyl-L-alanine amidase
K4756_06690	COG4195	phage-related replication protein
K4756_06695	COG3546	catalase activity
K4756_06700	COG2856	Zn peptidase
K4756_06705	COG1396	sequence-specific DNA binding
K4756_06715	COG1522	sequence-specific DNA binding
K4756_06720	COG1484	DNA-dependent DNA replication
K4756_06740	COG1595	DNA-templated transcription, initiation
K4756_06745	COG3728	DNA packaging
K4756_06745	COG5484	DNA packaging
K4756_06750	COG1783	phage Terminase large subunit
K4756_06755	COG5518	Phage portal protein
K4756_06760	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K4756_06765	COG4653	Phage capsid family
K4756_06815	COG3953	SLT domain
K4756_06815	COG5412	phage tail tape measure protein
K4756_06820	COG1652	LysM domain
K4756_06825	COG4193	domain, Protein
K4756_06835	COG3628	GPW Gp25 family protein
K4756_06840	COG3299	homolog of phage Mu protein gp47
K4756_06845	COG3778	Protein conserved in bacteria
K4756_06885	COG5632	N-Acetylmuramoyl-L-alanine amidase
K4756_06885	COG3409	Peptidoglycan-binding domain 1 protein
K4756_06905	COG0306	phosphate transporter
K4756_06910	COG1392	Phosphate transport regulator
K4756_06915	COG0531	amino acid
K4756_06920	COG0346	lactoylglutathione lyase activity
K4756_06930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K4756_06935	COG0463	Glycosyl transferase, family 2
K4756_06940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4756_06945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K4756_06950	COG2362	D-Aminopeptidase
K4756_06955	COG0601	transmembrane transport
K4756_06960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K4756_06965	COG0444	Belongs to the ABC transporter superfamily
K4756_06970	COG4166	transmembrane transport
K4756_06975	COG1619	proteins homologs of microcin C7 resistance protein MccF
K4756_06980	COG4948	Mandelate Racemase Muconate Lactonizing
K4756_06985	COG0791	NLP P60 protein
K4756_06990	COG4608	Belongs to the ABC transporter superfamily
K4756_06995	COG2706	6-phosphogluconolactonase activity
K4756_07000	COG1834	amidinotransferase
K4756_07005	COG1607	acyl-coa hydrolase
K4756_07010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K4756_07010	COG1017	nitric oxide dioxygenase activity
K4756_07020	COG2323	membrane
K4756_07025	COG2318	DinB family
K4756_07030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4756_07035	COG2076	Multidrug Resistance protein
K4756_07040	COG2076	Multidrug Resistance protein
K4756_07045	COG0788	formyltetrahydrofolate deformylase activity
K4756_07050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K4756_07055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K4756_07060	COG1764	response to oxidative stress
K4756_07065	COG1846	Transcriptional regulator
K4756_07070	COG1764	response to oxidative stress
K4756_07075	COG0590	tRNA wobble adenosine to inosine editing
K4756_07085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K4756_07090	COG1404	Belongs to the peptidase S8 family
K4756_07095	COG1366	Belongs to the anti-sigma-factor antagonist family
K4756_07100	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K4756_07105	COG1122	ATPase activity
K4756_07110	COG4721	ABC-type cobalt transport system, permease component
K4756_07120	COG0745	RESPONSE REGULATOR receiver
K4756_07125	COG5002	protein histidine kinase activity
K4756_07125	COG3850	Histidine kinase
K4756_07130	COG3212	peptidase
K4756_07135	COG3212	peptidase
K4756_07145	COG2239	Acts as a magnesium transporter
K4756_07150	COG0789	Transcriptional regulator
K4756_07165	COG1846	Transcriptional regulator
K4756_07170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K4756_07175	COG0726	polysaccharide deacetylase
K4756_07180	COG1408	metallophosphoesterase
K4756_07190	COG0463	Glycosyl transferase, family 2
K4756_07195	COG3285	dna ligase
K4756_07195	COG1793	dna ligase
K4756_07200	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K4756_07205	COG3300	MHYT domain
K4756_07205	COG5001	Diguanylate cyclase
K4756_07210	COG0586	Pfam SNARE associated Golgi protein
K4756_07215	COG0861	Integral membrane protein TerC family
K4756_07220	COG1191	sigma factor activity
K4756_07240	COG0501	Belongs to the peptidase M48B family
K4756_07245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K4756_07260	COG3594	Acyltransferase
K4756_07265	COG5002	protein histidine kinase activity
K4756_07270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K4756_07280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K4756_07285	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K4756_07290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K4756_07295	COG0436	Aminotransferase
K4756_07300	COG1850	ribulose-bisphosphate carboxylase activity
K4756_07305	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K4756_07310	COG0235	Class ii aldolase
K4756_07315	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K4756_07320	COG3339	Conserved Protein
K4756_07335	COG3852	Histidine kinase
K4756_07340	COG1846	Transcriptional regulator
K4756_07345	COG1360	Flagellar Motor Protein
K4756_07350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K4756_07355	COG0542	response to heat
K4756_07360	COG3949	Membrane
K4756_07365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K4756_07370	COG0720	synthase
K4756_07375	COG0602	queuosine metabolic process
K4756_07380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K4756_07385	COG4641	Protein conserved in bacteria
K4756_07385	COG1388	LysM domain
K4756_07390	COG1388	LysM domain
K4756_07395	COG3858	chitin binding
K4756_07405	COG4873	Protein conserved in bacteria
K4756_07415	COG3773	Cell wall hydrolase
K4756_07420	COG2244	polysaccharide biosynthetic process
K4756_07425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4756_07430	COG2217	Heavy metal translocating P-type atpase
K4756_07440	COG0006	proline dipeptidase activity
K4756_07445	COG1609	Transcriptional regulator
K4756_07450	COG3711	transcriptional antiterminator
K4756_07455	COG2190	(PTS) system
K4756_07455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_07455	COG1263	PTS System
K4756_07460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4756_07465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K4756_07475	COG1533	DNA photolyase activity
K4756_07480	COG0456	acetyltransferase
K4756_07485	COG0840	transmembrane signaling receptor activity
K4756_07490	COG2084	Dehydrogenase
K4756_07495	COG2340	Cysteine-rich secretory protein family
K4756_07505	COG4191	Histidine kinase
K4756_07510	COG0436	Aminotransferase
K4756_07520	COG0835	chemotaxis
K4756_07520	COG0784	Response regulator, receiver
K4756_07530	COG2814	Major facilitator Superfamily
K4756_07535	COG1376	ErfK ybiS ycfS ynhG family protein
K4756_07540	COG1408	metallophosphoesterase
K4756_07545	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_07550	COG2200	EAL domain
K4756_07555	COG4703	Protein of unknown function (DUF1797)
K4756_07560	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
K4756_07570	COG0517	IMP dehydrogenase activity
K4756_07575	COG0583	DNA-binding transcription factor activity
K4756_07580	COG0716	FMN binding
K4756_07590	COG0716	FMN binding
K4756_07595	COG2171	N-acyltransferase activity
K4756_07600	COG1473	amidohydrolase
K4756_07610	COG0668	transmembrane transport
K4756_07615	COG0450	alkyl hydroperoxide reductase
K4756_07620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4756_07635	COG0746	molybdenum cofactor guanylyltransferase activity
K4756_07640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K4756_07645	COG0303	'Molybdopterin
K4756_07650	COG1763	Mo-molybdopterin cofactor biosynthetic process
K4756_07655	COG0314	molybdopterin synthase activity
K4756_07660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K4756_07665	COG1132	(ABC) transporter
K4756_07670	COG1132	(ABC) transporter
K4756_07680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K4756_07685	COG1136	(ABC) transporter
K4756_07690	COG0577	efflux transmembrane transporter activity
K4756_07695	COG1349	DNA-binding transcription factor activity
K4756_07700	COG1105	Belongs to the carbohydrate kinase PfkB family
K4756_07705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4756_07705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4756_07705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4756_07710	COG0681	Belongs to the peptidase S26 family
K4756_07720	COG0488	(ABC) transporter
K4756_07730	COG2309	aminopeptidase activity
K4756_07740	COG1077	Cell shape determining protein MreB Mrl
K4756_07745	COG2002	toxin-antitoxin pair type II binding
K4756_07750	COG3852	Histidine kinase
K4756_07755	COG2105	PFAM AIG2 family protein
K4756_07755	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K4756_07760	COG0569	domain protein
K4756_07765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K4756_07770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K4756_07775	COG5503	Protein of unknown function (DUF1447)
K4756_07780	COG0561	phosphatase activity
K4756_07785	COG0242	peptide deformylase activity
K4756_07795	COG0497	DNA recombination
K4756_07800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K4756_07805	COG0022	dehydrogenase e1 component
K4756_07815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4756_07820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4756_07830	COG1982	Orn Lys Arg decarboxylase major
K4756_07835	COG4476	Belongs to the UPF0223 family
K4756_07840	COG4493	Belongs to the UPF0637 family
K4756_07850	COG0483	inositol monophosphate 1-phosphatase activity
K4756_07860	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K4756_07880	COG1595	DNA-templated transcription, initiation
K4756_07900	COG1217	gtp-binding protein TYPA
K4756_07910	COG4896	Protein conserved in bacteria
K4756_07920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K4756_07925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K4756_07930	COG2066	Belongs to the glutaminase family
K4756_07935	COG4838	Belongs to the UPF0358 family
K4756_07940	COG0772	Belongs to the SEDS family
K4756_07945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K4756_07950	COG1612	heme a metabolic process
K4756_07955	COG0109	protoheme IX farnesyltransferase activity
K4756_07960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K4756_07960	COG2010	Cytochrome c
K4756_07965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K4756_07970	COG1845	cytochrome c oxidase, subunit III
K4756_07975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K4756_07980	COG3336	cytochrome c oxidase
K4756_07990	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K4756_07995	COG2340	Cysteine-rich secretory protein family
K4756_08010	COG3679	Belongs to the UPF0342 family
K4756_08015	COG4471	UPF0298 protein
K4756_08020	COG0742	ribosomal rna small subunit methyltransferase
K4756_08025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K4756_08030	COG3314	Sporulation integral membrane protein YlbJ
K4756_08035	COG1752	Esterase of the alpha-beta hydrolase superfamily
K4756_08060	COG1399	metal-binding, possibly nucleic acid-binding protein
K4756_08075	COG0454	-acetyltransferase
K4756_08080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K4756_08085	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
K4756_08090	COG2001	Belongs to the MraZ family
K4756_08095	COG0275	rRNA processing
K4756_08100	COG4839	cell division protein FtsL
K4756_08105	COG0768	penicillin binding
K4756_08110	COG0768	penicillin binding
K4756_08115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K4756_08120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K4756_08125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K4756_08130	COG0772	Belongs to the SEDS family
K4756_08135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K4756_08140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K4756_08145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K4756_08150	COG3879	Bacterial protein of unknown function (DUF881)
K4756_08155	COG3879	Bacterial protein of unknown function (DUF881)
K4756_08160	COG3856	small basic protein
K4756_08165	COG0849	cell division
K4756_08170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K4756_08185	COG1191	sigma factor activity
K4756_08190	COG1191	sigma factor activity
K4756_08195	COG1119	ATPase activity
K4756_08200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K4756_08205	COG1873	PFAM PRC-barrel domain
K4756_08210	COG1496	oxidoreductase activity
K4756_08215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K4756_08220	COG1799	cell septum assembly
K4756_08225	COG0762	integral membrane protein
K4756_08230	COG2302	S4 RNA-binding domain
K4756_08235	COG3599	regulation of cell shape
K4756_08240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K4756_08245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K4756_08250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K4756_08255	COG0564	pseudouridine synthase activity
K4756_08260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K4756_08265	COG2233	PERMEase
K4756_08270	COG0540	Belongs to the ATCase OTCase family
K4756_08275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K4756_08280	COG0505	Belongs to the CarA family
K4756_08285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K4756_08290	COG0543	2 iron, 2 sulfur cluster binding
K4756_08295	COG0167	dihydroorotate dehydrogenase activity
K4756_08300	COG0284	orotidine-5'-phosphate decarboxylase activity
K4756_08305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K4756_08310	COG0175	sulfate reduction
K4756_08315	COG0306	phosphate transporter
K4756_08320	COG2046	Belongs to the sulfate adenylyltransferase family
K4756_08325	COG0529	Catalyzes the synthesis of activated sulfate
K4756_08330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K4756_08335	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
K4756_08340	COG1648	precorrin-2 dehydrogenase activity
K4756_08345	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K4756_08350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K4756_08355	COG1561	YicC-like family, N-terminal region
K4756_08365	COG0194	GDP metabolic process
K4756_08370	COG1758	RNA polymerase activity
K4756_08375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K4756_08380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K4756_08385	COG0242	peptide deformylase activity
K4756_08390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K4756_08395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K4756_08395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K4756_08400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K4756_08405	COG0631	protein serine/threonine phosphatase activity
K4756_08410	COG2815	serine threonine protein kinase
K4756_08410	COG0515	serine threonine protein kinase
K4756_08415	COG1162	GTPase activity
K4756_08420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K4756_08425	COG1564	THIamine pyrophosphokinase
K4756_08435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K4756_08440	COG1302	Protein conserved in bacteria
K4756_08445	COG1461	Dihydroxyacetone kinase
K4756_08450	COG1760	l-serine dehydratase
K4756_08455	COG1760	l-serine dehydratase
K4756_08460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K4756_08465	COG2050	protein possibly involved in aromatic compounds catabolism
K4756_08465	COG1349	DNA-binding transcription factor activity
K4756_08470	COG0416	fatty acid biosynthetic process
K4756_08475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K4756_08480	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_08490	COG0571	ribonuclease III activity
K4756_08495	COG1196	nuclear chromosome segregation
K4756_08500	COG0552	protein localization to endoplasmic reticulum
K4756_08510	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K4756_08515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K4756_08520	COG0228	four-way junction DNA binding
K4756_08525	COG1837	Belongs to the UPF0109 family
K4756_08535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K4756_08540	COG0336	Belongs to the RNA methyltransferase TrmD family
K4756_08545	COG0335	large ribosomal subunit rRNA binding
K4756_08550	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K4756_08555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K4756_08565	COG2257	FlhB HrpN YscU SpaS Family
K4756_08570	COG0045	succinate-CoA ligase (ADP-forming) activity
K4756_08575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K4756_08585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K4756_08590	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K4756_08595	COG4974	Belongs to the 'phage' integrase family
K4756_08600	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K4756_08605	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K4756_08610	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K4756_08615	COG1815	bacterial-type flagellum-dependent cell motility
K4756_08620	COG1558	bacterial-type flagellum-dependent cell motility
K4756_08625	COG1677	Flagellar hook-basal body complex protein FliE
K4756_08630	COG1766	The M ring may be actively involved in energy transduction
K4756_08635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K4756_08640	COG1317	bacterial-type flagellum organization
K4756_08645	COG1157	protein secretion by the type III secretion system
K4756_08650	COG2882	bacterial-type flagellum organization
K4756_08655	COG3334	PFAM MgtE intracellular
K4756_08660	COG3144	bacterial-type flagellum assembly
K4756_08665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K4756_08670	COG4786	Flagellar basal body rod
K4756_08675	COG1582	Flagellar protein (FlbD)
K4756_08680	COG1580	Controls the rotational direction of flagella during chemotaxis
K4756_08685	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K4756_08690	COG1776	CheC inhibitor of MCP methylation
K4756_08690	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K4756_08695	COG2201	protein-glutamate methylesterase activity
K4756_08700	COG3190	flagellar
K4756_08705	COG1338	Plays a role in the flagellum-specific transport system
K4756_08710	COG1987	bacterial-type flagellum assembly
K4756_08715	COG1684	flagellar biosynthetic protein fliR
K4756_08720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K4756_08725	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K4756_08730	COG1419	protein localization to endoplasmic reticulum
K4756_08735	COG0455	bacterial-type flagellum organization
K4756_08740	COG2201	protein-glutamate methylesterase activity
K4756_08745	COG0643	Histidine kinase
K4756_08745	COG2198	Histidine kinase
K4756_08750	COG0835	chemotaxis
K4756_08755	COG1776	CheC inhibitor of MCP methylation
K4756_08760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K4756_08765	COG1191	sigma factor activity
K4756_08775	COG0052	Belongs to the universal ribosomal protein uS2 family
K4756_08780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K4756_08785	COG0528	UMP kinase activity
K4756_08790	COG0233	cytoplasmic translational termination
K4756_08795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K4756_08800	COG4589	Belongs to the CDS family
K4756_08805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K4756_08810	COG0750	zinc metalloprotease
K4756_08815	COG0442	prolyl-tRNA aminoacylation
K4756_08820	COG2176	DNA-directed DNA polymerase activity
K4756_08825	COG0779	Required for maturation of 30S ribosomal subunits
K4756_08830	COG0195	Participates in both transcription termination and antitermination
K4756_08835	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K4756_08840	COG1358	cellular component organization or biogenesis
K4756_08845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K4756_08850	COG1550	Protein conserved in bacteria
K4756_08855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K4756_08860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K4756_08865	COG0196	riboflavin kinase activity
K4756_08870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K4756_08875	COG1185	polyribonucleotide nucleotidyltransferase activity
K4756_08880	COG0726	polysaccharide deacetylase
K4756_08885	COG0612	Peptidase, M16
K4756_08890	COG1873	PFAM PRC-barrel domain
K4756_08895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K4756_08900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K4756_08905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K4756_08910	COG0527	aspartate kinase activity
K4756_08915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K4756_08920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K4756_08925	COG0740	serine-type endopeptidase activity
K4756_08935	COG4980	gas vesicle protein
K4756_08935	COG1674	ftsk spoiiie
K4756_08940	COG2188	Transcriptional regulator
K4756_08945	COG2814	Major facilitator Superfamily
K4756_08950	COG0612	Peptidase, M16
K4756_08955	COG0612	Peptidase, M16
K4756_08960	COG0300	oxidoreductase activity
K4756_08975	COG1426	Protein conserved in bacteria
K4756_08980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K4756_08985	COG1546	Belongs to the CinA family
K4756_08985	COG1058	Belongs to the CinA family
K4756_08990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K4756_08995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K4756_09000	COG1418	mRNA catabolic process
K4756_09005	COG1692	metallophosphoesterase
K4756_09010	COG2359	stage V sporulation protein S
K4756_09015	COG1063	alcohol dehydrogenase
K4756_09020	COG0156	8-amino-7-oxononanoate synthase activity
K4756_09025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K4756_09030	COG4550	Control of competence regulator ComK, YlbF/YmcA
K4756_09040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K4756_09045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K4756_09060	COG3226	Transcriptional regulator
K4756_09065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4756_09075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K4756_09080	COG3321	synthase
K4756_09085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K4756_09085	COG2070	2-Nitropropane dioxygenase
K4756_09090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K4756_09095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K4756_09100	COG3425	synthase
K4756_09105	COG1024	Enoyl-CoA hydratase
K4756_09110	COG1024	Enoyl-CoA hydratase
K4756_09115	COG3321	synthase
K4756_09115	COG0318	PFAM AMP-dependent synthetase and ligase
K4756_09115	COG0300	oxidoreductase activity
K4756_09115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_09115	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_09120	COG3321	synthase
K4756_09120	COG4221	oxidoreductase activity
K4756_09120	COG0300	oxidoreductase activity
K4756_09120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K4756_09125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4756_09125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_09125	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_09125	COG3321	synthase
K4756_09125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K4756_09130	COG4221	oxidoreductase activity
K4756_09130	COG3321	synthase
K4756_09130	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_09130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_09135	COG3321	synthase
K4756_09135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K4756_09135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K4756_09135	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K4756_09140	COG2124	cytochrome p450
K4756_09150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4756_09155	COG1404	Belongs to the peptidase S8 family
K4756_09165	COG4195	phage-related replication protein
K4756_09170	COG1764	response to oxidative stress
K4756_09175	COG2076	Multidrug Resistance protein
K4756_09180	COG2076	Multidrug Resistance protein
K4756_09195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K4756_09200	COG1923	regulation of RNA biosynthetic process
K4756_09215	COG1780	Probably involved in ribonucleotide reductase function
K4756_09220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K4756_09225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K4756_09230	COG4112	unkown
K4756_09235	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4756_09240	COG0464	growth
K4756_09245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K4756_09250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K4756_09255	COG0789	Transcriptional regulator
K4756_09260	COG0174	glutamine synthetase
K4756_09305	COG4282	regulation of fungal-type cell wall biogenesis
K4756_09315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4756_09330	COG3655	Transcriptional regulator
K4756_09360	COG2211	Major facilitator Superfamily
K4756_09365	COG3507	Belongs to the glycosyl hydrolase 43 family
K4756_09370	COG1940	carbohydrate kinase activity
K4756_09375	COG2115	Belongs to the xylose isomerase family
K4756_09380	COG1070	Carbohydrate kinase
K4756_09390	COG1525	nuclease
K4756_09395	COG2814	Major facilitator Superfamily
K4756_09400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K4756_09410	COG0756	dUTP diphosphatase activity
K4756_09425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K4756_09455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K4756_09465	COG3832	glyoxalase III activity
K4756_09480	COG0697	spore germination
K4756_09485	COG0531	amino acid
K4756_09515	COG4195	phage-related replication protein
K4756_09525	COG0346	lactoylglutathione lyase activity
K4756_09530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K4756_09535	COG1388	LysM domain
K4756_09540	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K4756_09545	COG4224	UPF0291 protein
K4756_09550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K4756_09560	COG3763	UPF0154 protein
K4756_09570	COG0785	Cytochrome C biogenesis protein
K4756_09575	COG2201	protein-glutamate methylesterase activity
K4756_09580	COG4846	Membrane protein involved in cytochrome C biogenesis
K4756_09590	COG0071	Belongs to the small heat shock protein (HSP20) family
K4756_09605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K4756_09610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4756_09630	COG0824	Thioesterase
K4756_09640	COG4841	protein insertion into membrane
K4756_09645	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K4756_09650	COG1832	CoA-binding protein
K4756_09655	COG0187	DNA topoisomerase II activity
K4756_09660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K4756_09670	COG1115	amino acid carrier protein
K4756_09675	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K4756_09690	COG5520	Belongs to the glycosyl hydrolase 30 family
K4756_09695	COG3507	Belongs to the glycosyl hydrolase 43 family
K4756_09700	COG2246	polysaccharide biosynthetic process
K4756_09705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K4756_09710	COG0586	Pfam SNARE associated Golgi protein
K4756_09715	COG2404	hydrolase activity, acting on ester bonds
K4756_09720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K4756_09725	COG1024	Enoyl-CoA hydratase
K4756_09730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K4756_09735	COG0511	ligase activity, forming carbon-carbon bonds
K4756_09740	COG0439	Biotin carboxylase
K4756_09745	COG0318	PFAM AMP-dependent synthetase and ligase
K4756_09750	COG1960	acyl-CoA dehydrogenase activity
K4756_09765	COG1649	PFAM Uncharacterised BCR, COG1649
K4756_09775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_09775	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K4756_09780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_09785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_09790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_09795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_09800	COG2027	D-alanyl-D-alanine carboxypeptidase
K4756_09805	COG2017	converts alpha-aldose to the beta-anomer
K4756_09810	COG0534	Mate efflux family protein
K4756_09825	COG0582	viral genome integration into host DNA
K4756_09830	COG0166	Belongs to the GPI family
K4756_09835	COG0405	Gamma-glutamyltransferase
K4756_09840	COG0583	DNA-binding transcription factor activity
K4756_09845	COG0604	alcohol dehydrogenase
K4756_09850	COG0493	'glutamate synthase
K4756_09855	COG0070	glutamate synthase
K4756_09855	COG0069	glutamate synthase activity
K4756_09855	COG0067	glutamate synthase
K4756_09860	COG0583	DNA-binding transcription factor activity
K4756_09865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K4756_09870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K4756_09880	COG0300	oxidoreductase activity
K4756_09885	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
K4756_09895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4756_09900	COG2814	Major facilitator Superfamily
K4756_09905	COG1070	Carbohydrate kinase
K4756_09910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K4756_09940	COG5278	phosphoserine phosphatase activity
K4756_09940	COG0840	transmembrane signaling receptor activity
K4756_09945	COG2368	4-hydroxyphenylacetate
K4756_09950	COG4305	rare lipoprotein A
K4756_09955	COG3619	membrane
K4756_09960	COG3866	Pectate lyase
K4756_09965	COG2135	peptidase activity
K4756_10005	COG2720	vancomycin resistance protein
K4756_10020	COG3739	integral membrane protein
K4756_10025	COG0583	DNA-binding transcription factor activity
K4756_10030	COG0697	spore germination
K4756_10040	COG0693	protein deglycase activity
K4756_10045	COG2367	Beta-lactamase
K4756_10060	COG3848	Pyruvate phosphate dikinase
K4756_10060	COG0574	Belongs to the PEP-utilizing enzyme family
K4756_10065	COG0726	polysaccharide deacetylase
K4756_10070	COG1793	dna ligase
K4756_10110	COG5444	nuclease activity
K4756_10115	COG4282	regulation of fungal-type cell wall biogenesis
K4756_10120	COG1231	oxidoreductase activity
K4756_10125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4756_10130	COG0662	Cupin 2, conserved barrel domain protein
K4756_10130	COG2207	Transcriptional regulator
K4756_10135	COG1309	transcriptional regulator
K4756_10140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4756_10145	COG3708	Transcriptional regulator
K4756_10150	COG2378	regulation of single-species biofilm formation
K4756_10160	COG0640	Transcriptional regulator
K4756_10165	COG0741	lytic transglycosylase activity
K4756_10170	COG2322	membrane
K4756_10185	COG1619	proteins homologs of microcin C7 resistance protein MccF
K4756_10190	COG3239	Fatty acid desaturase
K4756_10195	COG4585	Histidine kinase
K4756_10200	COG2197	response regulator
K4756_10205	COG1388	LysM domain
K4756_10205	COG3584	3D domain protein
K4756_10210	COG0514	ATP-dependent DNA helicase (RecQ)
K4756_10220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K4756_10225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K4756_10240	COG0071	Belongs to the small heat shock protein (HSP20) family
K4756_10265	COG1012	belongs to the aldehyde dehydrogenase family
K4756_10270	COG1657	PFAM Prenyltransferase squalene oxidase
K4756_10275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K4756_10280	COG0733	neurotransmitter:sodium symporter activity
K4756_10285	COG0385	Bile acid
K4756_10290	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4756_10295	COG0567	Dehydrogenase, E1 component
K4756_10300	COG4548	von Willebrand factor, type A
K4756_10305	COG0714	Associated with various cellular activities
K4756_10310	COG2032	superoxide dismutase activity
K4756_10315	COG0791	NLP P60 protein
K4756_10315	COG1388	LysM domain
K4756_10320	COG1819	glycosyl
K4756_10325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K4756_10330	COG0534	Mate efflux family protein
K4756_10335	COG1366	Belongs to the anti-sigma-factor antagonist family
K4756_10340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K4756_10345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K4756_10355	COG2962	Rard protein
K4756_10370	COG2610	gluconate transmembrane transporter activity
K4756_10375	COG1942	4-Oxalocrotonate Tautomerase
K4756_10380	COG1733	regulation of RNA biosynthetic process
K4756_10385	COG0778	Nitroreductase
K4756_10390	COG0400	carboxylic ester hydrolase activity
K4756_10395	COG0346	lactoylglutathione lyase activity
K4756_10405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4756_10410	COG3409	Peptidoglycan-binding domain 1 protein
K4756_10410	COG0793	Belongs to the peptidase S41A family
K4756_10415	COG2226	methyltransferase
K4756_10425	COG1876	peptidase activity
K4756_10430	COG0813	purine-nucleoside phosphorylase activity
K4756_10445	COG0671	phosphoesterase, PA-phosphatase related
K4756_10465	COG4479	Belongs to the UPF0346 family
K4756_10475	COG1509	lysine 2,3-aminomutase activity
K4756_10480	COG0456	acetyltransferase
K4756_10485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K4756_10490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K4756_10495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K4756_10500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K4756_10515	COG0456	acetyltransferase
K4756_10535	COG4641	Protein conserved in bacteria
K4756_10540	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
K4756_10545	COG1086	Polysaccharide biosynthesis protein
K4756_10550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K4756_10555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K4756_10560	COG1846	Transcriptional regulator
K4756_10565	COG0534	Mate efflux family protein
K4756_10575	COG4698	Protein conserved in bacteria
K4756_10580	COG2755	lipolytic protein G-D-S-L family
K4756_10585	COG1999	signal sequence binding
K4756_10595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K4756_10600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K4756_10605	COG1272	protein, Hemolysin III
K4756_10610	COG0204	Acyl-transferase
K4756_10615	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K4756_10620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K4756_10625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K4756_10635	COG2136	Putative SAM-dependent methyltransferase
K4756_10635	COG2521	methyltransferase
K4756_10645	COG0129	dihydroxy-acid dehydratase activity
K4756_10655	COG1413	lyase activity
K4756_10660	COG1418	mRNA catabolic process
K4756_10665	COG0386	Belongs to the glutathione peroxidase family
K4756_10670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K4756_10675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K4756_10685	COG1278	Cold shock
K4756_10705	COG0328	RNA-DNA hybrid ribonuclease activity
K4756_10710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K4756_10715	COG0328	RNA-DNA hybrid ribonuclease activity
K4756_10725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4756_10740	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K4756_10750	COG1755	Isoprenylcysteine carboxyl methyltransferase
K4756_10755	COG3424	synthase
K4756_10760	COG2233	PERMEase
K4756_10765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K4756_10770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K4756_10780	COG0800	Aldolase
K4756_10785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4756_10790	COG1609	Transcriptional regulator
K4756_10795	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K4756_10800	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_10805	COG1199	ATP-dependent helicase activity
K4756_10820	COG0116	Belongs to the methyltransferase superfamily
K4756_10835	COG4474	Belongs to the UPF0398 family
K4756_10850	COG3359	exonuclease
K4756_10855	COG1205	dead DEAH box helicase
K4756_10855	COG1111	helicase
K4756_10860	COG2190	(PTS) system
K4756_10865	COG0071	Belongs to the small heat shock protein (HSP20) family
K4756_10900	COG3331	DNA recombination
K4756_10905	COG4499	WXG100 protein secretion system (Wss), protein YukC
K4756_10905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4756_10915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K4756_10920	COG3935	DnaD domain protein
K4756_10925	COG0017	Asparaginyl-tRNA synthetase
K4756_10930	COG0436	Aminotransferase
K4756_10935	COG5353	protein conserved in bacteria
K4756_10945	COG1199	ATP-dependent helicase activity
K4756_10945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K4756_10950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K4756_10955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K4756_10960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K4756_10965	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K4756_10965	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K4756_10970	COG0617	tRNA 3'-terminal CCA addition
K4756_10975	COG0438	transferase activity, transferring glycosyl groups
K4756_10980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K4756_10985	COG1803	Methylglyoxal synthase
K4756_10990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K4756_10995	COG1694	Mazg nucleotide pyrophosphohydrolase
K4756_11000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4756_11010	COG4347	Protein of unknown function (DUF1405)
K4756_11015	COG2010	Cytochrome c
K4756_11015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K4756_11020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K4756_11025	COG0723	plastoquinol--plastocyanin reductase activity
K4756_11035	COG5582	Belongs to the UPF0302 family
K4756_11040	COG0457	Tetratricopeptide repeat
K4756_11045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K4756_11050	COG0287	Prephenate dehydrogenase
K4756_11055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K4756_11060	COG0159	tryptophan synthase activity
K4756_11065	COG0133	tryptophan synthase activity
K4756_11070	COG0135	phosphoribosylanthranilate isomerase activity
K4756_11080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K4756_11085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K4756_11090	COG4401	Chorismate mutase type I
K4756_11095	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K4756_11100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K4756_11105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K4756_11110	COG0105	UTP biosynthetic process
K4756_11115	COG0142	geranyltranstransferase activity
K4756_11120	COG2226	methyltransferase
K4756_11125	COG0142	geranyltranstransferase activity
K4756_11135	COG0302	gtp cyclohydrolase
K4756_11140	COG0776	regulation of translation
K4756_11145	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K4756_11160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K4756_11165	COG1160	GTP binding
K4756_11190	COG1304	FMN binding
K4756_11195	COG0539	negative regulation of cytoplasmic translation
K4756_11200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K4756_11210	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K4756_11215	COG2959	enzyme of heme biosynthesis
K4756_11220	COG3409	Peptidoglycan-binding domain 1 protein
K4756_11220	COG3773	Cell wall hydrolase
K4756_11225	COG2339	peptidase activity
K4756_11230	COG0492	ferredoxin-NADP+ reductase activity
K4756_11235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K4756_11240	COG4862	establishment of competence for transformation
K4756_11245	COG1408	metallophosphoesterase
K4756_11255	COG1388	LysM domain
K4756_11260	COG1266	CAAX protease self-immunity
K4756_11265	COG0514	ATP-dependent DNA helicase (RecQ)
K4756_11270	COG4955	Helix-turn-helix domain
K4756_11275	COG1141	Ferredoxin
K4756_11280	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K4756_11285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K4756_11290	COG0710	3-dehydroquinate dehydratase activity
K4756_11300	COG1595	DNA-templated transcription, initiation
K4756_11305	COG5002	protein histidine kinase activity
K4756_11310	COG0745	RESPONSE REGULATOR receiver
K4756_11315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K4756_11320	COG1333	cytochrome c biogenesis protein
K4756_11325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4756_11330	COG1187	pseudouridine synthase activity
K4756_11335	COG0700	Nucleoside recognition
K4756_11340	COG2715	membrane protein required for spore maturation
K4756_11345	COG1686	Belongs to the peptidase S11 family
K4756_11355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K4756_11360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K4756_11365	COG1547	Domain of unknown function (DUF309)
K4756_11370	COG0456	acetyltransferase
K4756_11375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K4756_11380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4756_11380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4756_11385	COG0307	riboflavin synthase, alpha
K4756_11390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K4756_11390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K4756_11400	COG0681	Belongs to the peptidase S26 family
K4756_11410	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
K4756_11420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K4756_11425	COG4086	secreted protein
K4756_11430	COG0019	diaminopimelate decarboxylase activity
K4756_11435	COG0697	spore germination
K4756_11450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K4756_11470	COG1191	sigma factor activity
K4756_11475	COG2172	sigma factor antagonist activity
K4756_11480	COG1366	Belongs to the anti-sigma-factor antagonist family
K4756_11485	COG1686	Belongs to the peptidase S11 family
K4756_11490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K4756_11495	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K4756_11500	COG4974	Belongs to the 'phage' integrase family
K4756_11510	COG0735	belongs to the Fur family
K4756_11515	COG1300	Membrane
K4756_11525	COG0281	malic enzyme
K4756_11530	COG1757	Na H antiporter
K4756_11535	COG1027	Aspartate ammonia-lyase
K4756_11540	COG0252	asparaginase activity
K4756_11545	COG1396	sequence-specific DNA binding
K4756_11550	COG1379	DNA repair
K4756_11555	COG0494	nUDIX hydrolase
K4756_11565	COG0667	Aldo Keto reductase
K4756_11575	COG1073	alpha beta
K4756_11585	COG4918	Iron-sulphur cluster biosynthesis
K4756_11590	COG0456	acetyltransferase
K4756_11590	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K4756_11595	COG2329	Antibiotic biosynthesis monooxygenase
K4756_11600	COG0456	acetyltransferase
K4756_11610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K4756_11620	COG2211	Major facilitator Superfamily
K4756_11630	COG0346	lactoylglutathione lyase activity
K4756_11635	COG1072	(Pantothenic acid kinase))
K4756_11640	COG3048	D-serine ammonia-lyase activity
K4756_11645	COG0300	oxidoreductase activity
K4756_11650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4756_11655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K4756_11660	COG4187	Peptidase family M20/M25/M40
K4756_11665	COG1902	pentaerythritol trinitrate reductase activity
K4756_11670	COG0596	Alpha beta hydrolase
K4756_11680	COG1234	tRNA 3'-trailer cleavage
K4756_11685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K4756_11690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K4756_11695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K4756_11705	COG0706	membrane insertase activity
K4756_11710	COG3361	conserved protein (COG2071)
K4756_11715	COG2195	Cleaves the N-terminal amino acid of tripeptides
K4756_11720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K4756_11725	COG0346	lactoylglutathione lyase activity
K4756_11735	COG1376	ErfK ybiS ycfS ynhG family protein
K4756_11740	COG4129	membrane
K4756_11745	COG1126	abc transporter atp-binding protein
K4756_11750	COG0765	amino acid transport
K4756_11755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4756_11765	COG1597	lipid kinase activity
K4756_11770	COG2814	Major facilitator Superfamily
K4756_11775	COG0789	Transcriptional regulator
K4756_11775	COG4978	Transcriptional regulator
K4756_11780	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4756_11785	COG0022	dehydrogenase e1 component
K4756_11790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K4756_11795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4756_11800	COG3426	butyrate kinase activity
K4756_11805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K4756_11810	COG0280	phosphate acetyltransferase
K4756_11815	COG3829	transcription factor binding
K4756_11815	COG3290	protein histidine kinase activity
K4756_11825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K4756_11830	COG2079	MmgE PrpD family protein
K4756_11835	COG0372	Belongs to the citrate synthase family
K4756_11840	COG1960	acyl-CoA dehydrogenase activity
K4756_11845	COG1250	3-hydroxyacyl-CoA dehydrogenase
K4756_11850	COG0183	Belongs to the thiolase family
K4756_11855	COG0584	glycerophosphoryl diester phosphodiesterase
K4756_11860	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4756_11875	COG1902	pentaerythritol trinitrate reductase activity
K4756_11880	COG0745	RESPONSE REGULATOR receiver
K4756_11885	COG0750	zinc metalloprotease
K4756_11890	COG0497	DNA recombination
K4756_11895	COG1438	arginine binding
K4756_11900	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K4756_11905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K4756_11910	COG0142	geranyltranstransferase activity
K4756_11915	COG1722	exodeoxyribonuclease VII activity
K4756_11920	COG1570	exodeoxyribonuclease VII activity
K4756_11925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K4756_11930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K4756_11935	COG1302	Protein conserved in bacteria
K4756_11940	COG0439	Biotin carboxylase
K4756_11945	COG0511	ligase activity, forming carbon-carbon bonds
K4756_11985	COG3854	ATPases associated with a variety of cellular activities
K4756_11995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K4756_12000	COG0006	proline dipeptidase activity
K4756_12005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K4756_12015	COG3872	metal-dependent enzyme
K4756_12025	COG1752	Esterase of the alpha-beta hydrolase superfamily
K4756_12030	COG1321	iron dependent repressor
K4756_12035	COG0095	Lipoate-protein ligase
K4756_12040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K4756_12045	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K4756_12050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K4756_12055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K4756_12060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K4756_12075	COG1396	sequence-specific DNA binding
K4756_12085	COG0681	Belongs to the peptidase S26 family
K4756_12110	COG4940	Competence protein ComGF
K4756_12120	COG4970	Tfp pilus assembly protein FimT
K4756_12125	COG4537	Required for transformation and DNA binding
K4756_12135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K4756_12140	COG0598	Magnesium transport protein CorA
K4756_12145	COG1253	flavin adenine dinucleotide binding
K4756_12150	COG1366	Belongs to the anti-sigma-factor antagonist family
K4756_12160	COG1393	Belongs to the ArsC family
K4756_12170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4756_12180	COG0011	TIGRFAM Protein of
K4756_12190	COG2866	Carboxypeptidase
K4756_12195	COG1368	sulfuric ester hydrolase activity
K4756_12200	COG1940	carbohydrate kinase activity
K4756_12205	COG4483	Protein conserved in bacteria
K4756_12210	COG0705	Rhomboid family
K4756_12210	COG0457	Tetratricopeptide repeat
K4756_12220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K4756_12230	COG0438	transferase activity, transferring glycosyl groups
K4756_12245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K4756_12250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K4756_12255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K4756_12260	COG0581	inorganic phosphate transmembrane transporter activity
K4756_12265	COG0573	inorganic phosphate transmembrane transporter activity
K4756_12270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K4756_12275	COG0768	penicillin binding
K4756_12280	COG0477	Major facilitator Superfamily
K4756_12285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K4756_12290	COG2839	Protein conserved in bacteria
K4756_12295	COG5521	maltodextrose utilization protein MalA
K4756_12300	COG1388	LysM domain
K4756_12305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K4756_12310	COG4709	membrane
K4756_12315	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
K4756_12320	COG0735	belongs to the Fur family
K4756_12325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4756_12335	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K4756_12340	COG0513	Belongs to the DEAD box helicase family
K4756_12350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K4756_12355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K4756_12360	COG2384	SAM-dependent methyltransferase
K4756_12365	COG2010	Cytochrome c
K4756_12370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K4756_12375	COG0358	DNA primase activity
K4756_12380	COG1671	Belongs to the UPF0178 family
K4756_12385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K4756_12390	COG0517	IMP dehydrogenase activity
K4756_12395	COG0751	glycine-tRNA ligase activity
K4756_12400	COG0752	glycyl-tRNA synthetase alpha subunit
K4756_12405	COG1381	Involved in DNA repair and RecF pathway recombination
K4756_12415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K4756_12420	COG0295	cytidine deaminase activity
K4756_12425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K4756_12430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K4756_12435	COG1480	7TM receptor with intracellular HD hydrolase
K4756_12440	COG1702	phosphate starvation-inducible protein PhoH
K4756_12445	COG0561	phosphatase activity
K4756_12460	COG4864	UPF0365 protein
K4756_12470	COG1610	YqeY-like protein
K4756_12480	COG1283	sodium-dependent phosphate transmembrane transporter activity
K4756_12485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K4756_12490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K4756_12495	COG2264	protein methyltransferase activity
K4756_12500	COG0484	heat shock protein binding
K4756_12505	COG0443	Heat shock 70 kDa protein
K4756_12510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K4756_12515	COG1420	regulation of RNA biosynthetic process
K4756_12520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K4756_12525	COG0481	GTPase activity
K4756_12535	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4756_12540	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K4756_12545	COG0268	Binds directly to 16S ribosomal RNA
K4756_12550	COG1466	dna polymerase III delta subunit
K4756_12565	COG2333	competence protein COMEC
K4756_12565	COG0658	competence protein
K4756_12570	COG2131	deaminase
K4756_12575	COG1596	polysaccharide export
K4756_12575	COG1555	photosystem II stabilization
K4756_12580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K4756_12585	COG2226	methyltransferase
K4756_12590	COG0799	negative regulation of ribosome biogenesis
K4756_12595	COG1713	HD superfamily hydrolase involved in NAD metabolism
K4756_12600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K4756_12605	COG1534	Rna-binding protein
K4756_12610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K4756_12615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K4756_12620	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K4756_12630	COG2755	lipolytic protein G-D-S-L family
K4756_12635	COG5632	N-Acetylmuramoyl-L-alanine amidase
K4756_12635	COG3409	Peptidoglycan-binding domain 1 protein
K4756_12640	COG0398	Pfam SNARE associated Golgi protein
K4756_12645	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K4756_12655	COG3209	COG3209 Rhs family protein
K4756_12665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K4756_12675	COG3223	Belongs to the PsiE family
K4756_12680	COG5002	protein histidine kinase activity
K4756_12680	COG0642	Histidine kinase
K4756_12685	COG0745	RESPONSE REGULATOR receiver
K4756_12690	COG2311	Membrane
K4756_12695	COG0454	-acetyltransferase
K4756_12700	COG1733	regulation of RNA biosynthetic process
K4756_12705	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_12740	COG4824	toxin secretion phage lysis holin
K4756_12760	COG0563	adenylate kinase activity
K4756_12785	COG2249	NAD(P)H dehydrogenase (quinone) activity
K4756_12795	COG1846	Transcriptional regulator
K4756_12800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K4756_12810	COG0457	Tetratricopeptide repeat
K4756_12815	COG5444	nuclease activity
K4756_12840	COG0789	Transcriptional regulator
K4756_12840	COG4978	Transcriptional regulator
K4756_12845	COG2814	Major facilitator Superfamily
K4756_12850	COG0456	acetyltransferase
K4756_12855	COG1253	flavin adenine dinucleotide binding
K4756_12870	COG0583	DNA-binding transcription factor activity
K4756_12875	COG2072	flavoprotein involved in K transport
K4756_12880	COG1230	cation diffusion facilitator family transporter
K4756_12885	COG1942	4-Oxalocrotonate Tautomerase
K4756_12890	COG0583	DNA-binding transcription factor activity
K4756_12905	COG1114	Component of the transport system for branched-chain amino acids
K4756_12910	COG1687	branched-chain amino acid
K4756_12915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K4756_12920	COG1522	sequence-specific DNA binding
K4756_12930	COG2124	cytochrome p450
K4756_12940	COG1335	isochorismatase
K4756_12960	COG2318	DinB family
K4756_12970	COG2070	2-Nitropropane dioxygenase
K4756_12975	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K4756_12995	COG3443	Belongs to the bacterial solute-binding protein 9 family
K4756_13000	COG1595	DNA-templated transcription, initiation
K4756_13005	COG0667	Aldo Keto reductase
K4756_13010	COG3409	Peptidoglycan-binding domain 1 protein
K4756_13015	COG5566	PFAM Mor transcription activator
K4756_13020	COG0596	Alpha beta hydrolase
K4756_13025	COG4991	sh3 domain protein
K4756_13030	COG4991	sh3 domain protein
K4756_13040	COG0346	lactoylglutathione lyase activity
K4756_13050	COG5577	PFAM Coat F domain
K4756_13055	COG1063	alcohol dehydrogenase
K4756_13065	COG5577	PFAM Coat F domain
K4756_13070	COG0789	Transcriptional regulator
K4756_13080	COG1064	alcohol dehydrogenase
K4756_13085	COG0693	protein deglycase activity
K4756_13090	COG1621	beta-fructofuranosidase activity
K4756_13095	COG3716	PTS system mannose fructose sorbose family IID component
K4756_13100	COG3715	PTS system
K4756_13105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_13110	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4756_13115	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K4756_13115	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K4756_13125	COG1113	amino acid transport
K4756_13130	COG1280	lysine exporter protein (LysE YggA)
K4756_13135	COG1378	Sugar-specific transcriptional regulator TrmB
K4756_13140	COG1595	DNA-templated transcription, initiation
K4756_13150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K4756_13150	COG2755	lipolytic protein G-D-S-L family
K4756_13160	COG2124	cytochrome p450
K4756_13160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K4756_13165	COG1309	transcriptional regulator
K4756_13170	COG2226	methyltransferase
K4756_13185	COG2116	formate transmembrane transporter activity
K4756_13190	COG5609	conserved protein (DUF2294)
K4756_13195	COG3383	formate dehydrogenase (NAD+) activity
K4756_13200	COG2427	Protein of unknown function (DUF1641)
K4756_13210	COG0626	cystathionine gamma-synthase activity
K4756_13215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K4756_13220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K4756_13225	COG2226	methyltransferase
K4756_13240	COG0768	penicillin binding
K4756_13245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K4756_13250	COG0572	uridine kinase
K4756_13255	COG0826	peptidase U32
K4756_13260	COG0826	peptidase U32
K4756_13265	COG4122	O-methyltransferase activity
K4756_13270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K4756_13275	COG3906	Belongs to the UPF0473 family
K4756_13280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K4756_13285	COG4472	Bacterial protein of unknown function (DUF965)
K4756_13290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K4756_13295	COG0628	permease
K4756_13300	COG1126	abc transporter atp-binding protein
K4756_13305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4756_13310	COG0765	amino acid transport
K4756_13315	COG0765	amino acid transport
K4756_13330	COG3881	PFAM PRC-barrel domain
K4756_13335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K4756_13340	COG0457	Tetratricopeptide repeat
K4756_13345	COG0482	sulfurtransferase activity
K4756_13350	COG1104	cysteine desulfurase activity
K4756_13355	COG1959	2 iron, 2 sulfur cluster binding
K4756_13360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K4756_13365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K4756_13375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K4756_13380	COG0124	histidyl-tRNA synthetase
K4756_13390	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4756_13390	COG3103	Sh3 type 3 domain protein
K4756_13390	COG4991	sh3 domain protein
K4756_13395	COG1490	D-aminoacyl-tRNA deacylase activity
K4756_13400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K4756_13405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K4756_13410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K4756_13410	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K4756_13415	COG5416	Lipopolysaccharide assembly protein A domain
K4756_13420	COG0490	domain, Protein
K4756_13425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K4756_13425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K4756_13435	COG2244	polysaccharide biosynthetic process
K4756_13440	COG2323	membrane
K4756_13450	COG1862	Preprotein translocase
K4756_13455	COG0343	queuine tRNA-ribosyltransferase activity
K4756_13460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K4756_13470	COG2255	four-way junction helicase activity
K4756_13475	COG0632	four-way junction helicase activity
K4756_13485	COG2814	Major facilitator Superfamily
K4756_13490	COG0673	inositol 2-dehydrogenase activity
K4756_13495	COG2112	serine threonine protein kinase
K4756_13515	COG1115	amino acid carrier protein
K4756_13520	COG0217	transcriptional regulatory protein
K4756_13530	COG1388	LysM domain
K4756_13535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K4756_13540	COG0157	Belongs to the NadC ModD family
K4756_13545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K4756_13550	COG1104	cysteine desulfurase activity
K4756_13555	COG1827	regulation of RNA biosynthetic process
K4756_13565	COG4492	Belongs to the UPF0735 family
K4756_13570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K4756_13575	COG3290	protein histidine kinase activity
K4756_13585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K4756_13590	COG2868	ribosomal protein
K4756_13595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K4756_13605	COG0739	heme binding
K4756_13610	COG2894	cell division
K4756_13615	COG0850	regulation of cytokinetic process
K4756_13620	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K4756_13630	COG1077	Cell shape determining protein MreB Mrl
K4756_13635	COG2003	Belongs to the UPF0758 family
K4756_13640	COG0424	maF-like protein
K4756_13655	COG0285	dihydrofolate synthase activity
K4756_13660	COG0525	valine-tRNA ligase activity
K4756_13670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K4756_13675	COG1388	LysM domain
K4756_13680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K4756_13685	COG0113	porphobilinogen synthase activity
K4756_13690	COG1587	Uroporphyrinogen-III synthase
K4756_13695	COG0181	hydroxymethylbilane synthase activity
K4756_13700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K4756_13705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K4756_13715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K4756_13720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K4756_13725	COG1067	ATP-dependent peptidase activity
K4756_13725	COG0470	DNA polymerase III
K4756_13730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K4756_13735	COG0544	peptidyl-prolyl cis-trans isomerase activity
K4756_13740	COG1477	protein flavinylation
K4756_13740	COG0457	Tetratricopeptide repeat
K4756_13745	COG0066	3-isopropylmalate dehydratase activity
K4756_13750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K4756_13755	COG0473	3-isopropylmalate dehydrogenase activity
K4756_13760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K4756_13765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K4756_13770	COG0440	acetolactate synthase activity
K4756_13775	COG0028	Belongs to the TPP enzyme family
K4756_13785	COG0454	-acetyltransferase
K4756_13790	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
K4756_13800	COG0622	Phosphoesterase
K4756_13805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K4756_13810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K4756_13815	COG5401	PFAM Sporulation and spore germination
K4756_13820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K4756_13825	COG1846	Transcriptional regulator
K4756_13830	COG2197	response regulator
K4756_13835	COG0824	Thioesterase
K4756_13840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K4756_13845	COG1053	succinate dehydrogenase
K4756_13850	COG2009	succinate dehydrogenase
K4756_13855	COG1719	4-vinyl reductase, 4VR
K4756_13860	COG0527	aspartate kinase activity
K4756_13865	COG0322	excinuclease ABC activity
K4756_13870	COG3118	belongs to the thioredoxin family
K4756_13875	COG3534	alpha-L-arabinofuranosidase
K4756_13880	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K4756_13885	COG2086	electron transfer activity
K4756_13890	COG1024	Enoyl-CoA hydratase
K4756_13895	COG1309	transcriptional regulator
K4756_13900	COG0318	PFAM AMP-dependent synthetase and ligase
K4756_13905	COG3766	membrane
K4756_13910	COG1193	negative regulation of DNA recombination
K4756_13915	COG1796	DNA polymerase
K4756_13915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K4756_13920	COG1286	toxin biosynthetic process
K4756_13925	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K4756_13930	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K4756_13935	COG0072	phenylalanine-tRNA ligase activity
K4756_13935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4756_13940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K4756_13950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K4756_13960	COG3835	regulator
K4756_13965	COG0277	FAD linked oxidase domain protein
K4756_13970	COG0247	lactate metabolic process
K4756_13975	COG0346	lactoylglutathione lyase activity
K4756_13980	COG1966	Carbon starvation protein
K4756_13985	COG3534	alpha-L-arabinofuranosidase
K4756_13990	COG0395	ABC-type sugar transport system, permease component
K4756_13995	COG1175	transmembrane transport
K4756_14000	COG1653	transport
K4756_14005	COG0371	Dehydrogenase
K4756_14010	COG0647	UMP catabolic process
K4756_14015	COG0235	Class ii aldolase
K4756_14020	COG1069	ribulokinase activity
K4756_14025	COG2160	L-arabinose isomerase activity
K4756_14030	COG3507	Belongs to the glycosyl hydrolase 43 family
K4756_14035	COG1363	Peptidase, m42
K4756_14045	COG3326	Membrane
K4756_14050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K4756_14055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K4756_14060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K4756_14070	COG1346	cytolysis
K4756_14075	COG1380	Effector of murein hydrolase LrgA
K4756_14080	COG3279	Response regulator of the LytR AlgR family
K4756_14085	COG3275	phosphorelay sensor kinase activity
K4756_14090	COG1011	Hydrolase
K4756_14095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K4756_14105	COG0398	Pfam SNARE associated Golgi protein
K4756_14110	COG1484	DNA-dependent DNA replication
K4756_14115	COG3611	Membrane attachment protein
K4756_14120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K4756_14125	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K4756_14130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K4756_14135	COG1733	regulation of RNA biosynthetic process
K4756_14140	COG2814	Major facilitator Superfamily
K4756_14145	COG0656	L-ascorbic acid biosynthetic process
K4756_14150	COG0237	dephospho-CoA kinase activity
K4756_14155	COG1971	Probably functions as a manganese efflux pump
K4756_14160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K4756_14165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4756_14165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4756_14170	COG5002	protein histidine kinase activity
K4756_14175	COG0745	RESPONSE REGULATOR receiver
K4756_14180	COG0039	L-malate dehydrogenase activity
K4756_14185	COG0538	isocitrate dehydrogenase activity
K4756_14190	COG0372	Belongs to the citrate synthase family
K4756_14195	COG2707	UPF0756 membrane protein
K4756_14200	COG0628	permease
K4756_14205	COG3030	protein affecting phage T7 exclusion by the F plasmid
K4756_14210	COG0469	pyruvate kinase activity
K4756_14215	COG0205	6-phosphofructokinase activity
K4756_14220	COG0825	malonyl-CoA metabolic process
K4756_14225	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K4756_14230	COG0281	malic enzyme
K4756_14235	COG0587	DNA-directed DNA polymerase activity
K4756_14255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K4756_14265	COG4109	DRTGG domain
K4756_14270	COG0730	response to heat
K4756_14275	COG1473	amidohydrolase
K4756_14280	COG0196	riboflavin kinase activity
K4756_14285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4756_14290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K4756_14295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4756_14300	COG1126	abc transporter atp-binding protein
K4756_14305	COG0765	amino acid transport
K4756_14310	COG0765	amino acid transport
K4756_14315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4756_14320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4756_14325	COG0454	-acetyltransferase
K4756_14330	COG0583	DNA-binding transcription factor activity
K4756_14335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K4756_14340	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_14345	COG0165	Argininosuccinate lyase
K4756_14350	COG0137	argininosuccinate synthase activity
K4756_14355	COG0521	Mo-molybdopterin cofactor biosynthetic process
K4756_14360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K4756_14370	COG0827	DNA restriction-modification system
K4756_14375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K4756_14380	COG3874	Sporulation protein YtfJ
K4756_14390	COG1714	RDD family
K4756_14395	COG0616	signal peptide processing
K4756_14400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K4756_14405	COG1574	metal-dependent hydrolase with the TIM-barrel fold
K4756_14410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K4756_14420	COG0301	tRNA thio-modification
K4756_14425	COG1104	cysteine desulfurase activity
K4756_14430	COG1114	Component of the transport system for branched-chain amino acids
K4756_14435	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K4756_14440	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K4756_14445	COG1309	transcriptional regulator
K4756_14450	COG1956	GAF domain-containing protein
K4756_14455	COG2203	Gaf domain
K4756_14455	COG2199	diguanylate cyclase activity
K4756_14460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K4756_14465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K4756_14470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K4756_14475	COG0454	-acetyltransferase
K4756_14480	COG0517	IMP dehydrogenase activity
K4756_14485	COG0123	including yeast histone deacetylase and acetoin utilization protein
K4756_14490	COG1360	Flagellar Motor Protein
K4756_14495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K4756_14500	COG1609	Transcriptional regulator
K4756_14505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K4756_14505	COG1605	Chorismate mutase
K4756_14510	COG3118	belongs to the thioredoxin family
K4756_14520	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
K4756_14525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K4756_14530	COG1674	ftsk spoiiie
K4756_14535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4756_14540	COG4848	Belongs to the UPF0354 family
K4756_14545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4756_14560	COG1363	Peptidase, m42
K4756_14565	COG5584	Small secreted protein
K4756_14570	COG0281	malic enzyme
K4756_14575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4756_14580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K4756_14590	COG0510	thiamine kinase activity
K4756_14595	COG1523	belongs to the glycosyl hydrolase 13 family
K4756_14600	COG1597	lipid kinase activity
K4756_14610	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K4756_14615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K4756_14620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K4756_14625	COG2252	PERMEase
K4756_14630	COG4473	ABC transporter
K4756_14635	COG1131	(ABC) transporter
K4756_14640	COG1349	DNA-binding transcription factor activity
K4756_14645	COG1187	pseudouridine synthase activity
K4756_14650	COG2244	polysaccharide biosynthetic process
K4756_14655	COG2081	HI0933 family
K4756_14660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K4756_14670	COG5578	integral membrane protein
K4756_14675	COG0673	inositol 2-dehydrogenase activity
K4756_14680	COG1653	transport
K4756_14685	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K4756_14690	COG4209	transmembrane transport
K4756_14695	COG2207	Transcriptional regulator
K4756_14700	COG1653	transport
K4756_14705	COG0395	ABC-type sugar transport system, permease component
K4756_14710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4756_14715	COG2124	cytochrome p450
K4756_14720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K4756_14730	COG0156	8-amino-7-oxononanoate synthase activity
K4756_14735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K4756_14745	COG1073	alpha beta
K4756_14750	COG1609	Transcriptional regulator
K4756_14755	COG1653	transport
K4756_14760	COG1175	transmembrane transport
K4756_14765	COG0395	ABC-type sugar transport system, permease component
K4756_14770	COG1486	melibiose metabolic process
K4756_14775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K4756_14780	COG0495	leucyl-tRNA aminoacylation
K4756_14790	COG2202	Pas domain
K4756_14790	COG1366	Belongs to the anti-sigma-factor antagonist family
K4756_14795	COG2814	Major facilitator Superfamily
K4756_14800	COG2433	Pfam Transposase IS66
K4756_14805	COG0577	efflux transmembrane transporter activity
K4756_14810	COG1136	(ABC) transporter
K4756_14815	COG2205	protein histidine kinase activity
K4756_14820	COG0745	RESPONSE REGULATOR receiver
K4756_14825	COG0577	efflux transmembrane transporter activity
K4756_14830	COG1136	(ABC) transporter
K4756_14845	COG1131	(ABC) transporter
K4756_14850	COG1725	Transcriptional regulator
K4756_14865	COG1242	4 iron, 4 sulfur cluster binding
K4756_14870	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K4756_14880	COG2267	carboxylic ester hydrolase activity
K4756_14885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K4756_14890	COG1113	amino acid transport
K4756_14895	COG0367	asparagine synthase
K4756_14900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K4756_14905	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K4756_14915	COG1506	peptidase
K4756_14920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K4756_14925	COG1116	anion transmembrane transporter activity
K4756_14930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K4756_14935	COG0494	nUDIX hydrolase
K4756_14940	COG4824	toxin secretion phage lysis holin
K4756_14945	COG0783	Belongs to the Dps family
K4756_14960	COG1854	S-ribosylhomocysteine lyase activity
K4756_14965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K4756_14970	COG0288	reversible hydration of carbon dioxide
K4756_14975	COG0254	rRNA binding
K4756_14980	COG1271	oxidase subunit
K4756_14985	COG1294	oxidase, subunit
K4756_14995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K4756_15000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K4756_15000	COG1321	iron dependent repressor
K4756_15005	COG1121	(ABC) transporter
K4756_15010	COG0803	Belongs to the bacterial solute-binding protein 9 family
K4756_15015	COG4948	Mandelate Racemase Muconate Lactonizing
K4756_15020	COG0318	PFAM AMP-dependent synthetase and ligase
K4756_15025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K4756_15030	COG0596	Alpha beta hydrolase
K4756_15035	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K4756_15040	COG1169	isochorismate synthase
K4756_15045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K4756_15050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K4756_15055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K4756_15060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4756_15065	COG0438	transferase activity, transferring glycosyl groups
K4756_15075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K4756_15080	COG0438	transferase activity, transferring glycosyl groups
K4756_15085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K4756_15090	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K4756_15095	COG0058	SHG alpha-glucan phosphorylase activity
K4756_15100	COG0297	glycogen (starch) synthase activity
K4756_15105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K4756_15110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K4756_15115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K4756_15240	COG3859	Proton-coupled thiamine transporter YuaJ
K4756_15250	COG2268	Band 7 protein
K4756_15255	COG1585	Membrane protein implicated in regulation of membrane protease activity
K4756_15260	COG2318	DinB family
K4756_15270	COG1454	alcohol dehydrogenase
K4756_15275	COG1012	belongs to the aldehyde dehydrogenase family
K4756_15280	COG1510	regulation of RNA biosynthetic process
K4756_15290	COG0569	domain protein
K4756_15295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K4756_15300	COG4682	membrane
K4756_15305	COG1705	Flagellar rod assembly protein muramidase FlgJ
K4756_15310	COG0477	Major facilitator Superfamily
K4756_15325	COG1968	undecaprenyl-diphosphatase activity
K4756_15330	COG0628	permease
K4756_15335	COG0673	inositol 2-dehydrogenase activity
K4756_15340	COG4806	L-rhamnose isomerase
K4756_15345	COG3254	rhamnose metabolic process
K4756_15350	COG1070	Carbohydrate kinase
K4756_15355	COG1349	DNA-binding transcription factor activity
K4756_15360	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_15360	COG3347	Dehydrogenase
K4756_15365	COG0840	transmembrane signaling receptor activity
K4756_15370	COG0840	transmembrane signaling receptor activity
K4756_15375	COG0840	transmembrane signaling receptor activity
K4756_15380	COG0840	transmembrane signaling receptor activity
K4756_15400	COG0432	Pfam Uncharacterised protein family UPF0047
K4756_15405	COG0366	Alpha amylase catalytic
K4756_15410	COG1253	flavin adenine dinucleotide binding
K4756_15415	COG2738	Putative neutral zinc metallopeptidase
K4756_15430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K4756_15445	COG0166	Belongs to the GPI family
K4756_15450	COG1979	alcohol dehydrogenase
K4756_15455	COG1979	alcohol dehydrogenase
K4756_15460	COG2155	Conserved Protein
K4756_15465	COG1098	S1 RNA binding domain
K4756_15470	COG0436	Aminotransferase
K4756_15475	COG1522	sequence-specific DNA binding
K4756_15480	COG2267	carboxylic ester hydrolase activity
K4756_15490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K4756_15495	COG2205	protein histidine kinase activity
K4756_15505	COG5018	Exonuclease
K4756_15510	COG2814	Major facilitator Superfamily
K4756_15515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4756_15520	COG3011	Protein conserved in bacteria
K4756_15530	COG3290	protein histidine kinase activity
K4756_15535	COG4565	transcriptional regulatory protein
K4756_15540	COG1744	ABC transporter substrate-binding protein PnrA-like
K4756_15545	COG3845	ABC transporter
K4756_15550	COG4603	Belongs to the binding-protein-dependent transport system permease family
K4756_15555	COG1079	Belongs to the binding-protein-dependent transport system permease family
K4756_15560	COG3493	citrate carrier protein
K4756_15570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K4756_15570	COG2111	Na H antiporter
K4756_15575	COG2111	Na H antiporter
K4756_15580	COG1006	Multisubunit Na H antiporter MnhC subunit
K4756_15585	COG0651	ATP synthesis coupled electron transport
K4756_15590	COG1863	multisubunit Na H antiporter MnhE subunit
K4756_15595	COG2212	antiporter activity
K4756_15600	COG1320	monovalent cation:proton antiporter activity
K4756_15605	COG2050	protein possibly involved in aromatic compounds catabolism
K4756_15610	COG2197	response regulator
K4756_15615	COG4585	Histidine kinase
K4756_15625	COG0142	geranyltranstransferase activity
K4756_15640	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K4756_15645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K4756_15650	COG1335	isochorismatase
K4756_15655	COG5506	Protein of unknown function (DUF1694)
K4756_15670	COG0628	permease
K4756_15685	COG1418	mRNA catabolic process
K4756_15690	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_15700	COG1511	domain protein
K4756_15705	COG0433	COG0433 Predicted ATPase
K4756_15705	COG1674	ftsk spoiiie
K4756_15710	COG4499	WXG100 protein secretion system (Wss), protein YukC
K4756_15715	COG5417	Belongs to the EsaB family
K4756_15720	COG4842	Belongs to the WXG100 family
K4756_15725	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K4756_15725	COG2508	Transcriptional regulator
K4756_15730	COG0686	Belongs to the AlaDH PNT family
K4756_15735	COG5634	Uncharacterized conserved protein (DUF2278)
K4756_15740	COG3251	PFAM MbtH domain protein
K4756_15745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_15750	COG3433	isochorismatase activity
K4756_15750	COG1535	isochorismatase
K4756_15755	COG1021	2,3-dihydroxybenzoate-AMP ligase
K4756_15760	COG1169	isochorismate synthase
K4756_15765	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_15770	COG2819	hydrolase of the alpha beta superfamily
K4756_15775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K4756_15780	COG1268	BioY protein
K4756_15785	COG2056	Na+-H+ antiporter family
K4756_15790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K4756_15795	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K4756_15800	COG3584	3D domain protein
K4756_15815	COG1252	NADH dehydrogenase
K4756_15820	COG0492	ferredoxin-NADP+ reductase activity
K4756_15830	COG0516	GMP reductase activity
K4756_15835	COG2808	Putative FMN-binding domain
K4756_15840	COG0456	acetyltransferase
K4756_15845	COG0316	Belongs to the HesB IscA family
K4756_15850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K4756_15855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K4756_15860	COG4844	belongs to the
K4756_15865	COG1252	NADH dehydrogenase
K4756_15870	COG4837	Protein of unknown function (DUF1462)
K4756_15875	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K4756_15880	COG4946	Tricorn protease homolog
K4756_15880	COG0823	Involved in the tonB-independent uptake of proteins
K4756_15880	COG1506	peptidase
K4756_15885	COG0083	homoserine kinase activity
K4756_15890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K4756_15895	COG0460	homoserine dehydrogenase
K4756_15900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K4756_15905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K4756_15910	COG0647	UMP catabolic process
K4756_15915	COG2445	Protein of unknown function DUF86
K4756_15920	COG4470	Protein conserved in bacteria
K4756_15930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K4756_15935	COG0739	heme binding
K4756_15945	COG3377	Domain of unknown function (DUF1805)
K4756_15950	COG0737	Belongs to the 5'-nucleotidase family
K4756_15955	COG0730	response to heat
K4756_15960	COG1801	Protein of unknown function DUF72
K4756_15970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K4756_15975	COG2508	Transcriptional regulator
K4756_15980	COG2233	PERMEase
K4756_15985	COG2233	PERMEase
K4756_15990	COG3648	Uricase
K4756_15990	COG3195	allantoin biosynthetic process
K4756_15995	COG2351	hydroxyisourate hydrolase activity
K4756_16005	COG2080	2 iron, 2 sulfur cluster binding
K4756_16010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K4756_16015	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K4756_16020	COG2068	MobA-Related Protein
K4756_16025	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K4756_16030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K4756_16035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K4756_16045	COG2356	endonuclease I
K4756_16050	COG3842	ATPase activity
K4756_16055	COG2188	Transcriptional regulator
K4756_16060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4756_16065	COG0395	ABC-type sugar transport system, permease component
K4756_16070	COG1175	transmembrane transport
K4756_16075	COG1653	transport
K4756_16080	COG2222	sugar isomerase
K4756_16085	COG0322	excinuclease ABC activity
K4756_16090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4756_16105	COG0346	lactoylglutathione lyase activity
K4756_16110	COG0640	Transcriptional regulator
K4756_16115	COG0719	Fe-S assembly protein
K4756_16120	COG0822	iron-sulfur transferase activity
K4756_16125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K4756_16130	COG0719	Fe-S assembly protein
K4756_16135	COG0396	ATPase activity
K4756_16145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K4756_16150	COG1464	Belongs to the NlpA lipoprotein family
K4756_16155	COG2011	ABC-type metal ion transport system permease component
K4756_16160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K4756_16170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4756_16175	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K4756_16185	COG0509	glycine decarboxylation via glycine cleavage system
K4756_16190	COG1393	Belongs to the ArsC family
K4756_16195	COG1960	acyl-CoA dehydrogenase activity
K4756_16200	COG0183	Belongs to the thiolase family
K4756_16205	COG1024	Enoyl-CoA hydratase
K4756_16205	COG1250	3-hydroxyacyl-CoA dehydrogenase
K4756_16215	COG0506	proline dehydrogenase activity
K4756_16225	COG5577	PFAM Coat F domain
K4756_16230	COG1846	Transcriptional regulator
K4756_16235	COG0477	Major facilitator Superfamily
K4756_16240	COG1942	4-Oxalocrotonate Tautomerase
K4756_16245	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_16250	COG0583	DNA-binding transcription factor activity
K4756_16260	COG1120	ATPase activity
K4756_16275	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_16280	COG0783	Belongs to the Dps family
K4756_16285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4756_16290	COG0745	RESPONSE REGULATOR receiver
K4756_16295	COG2205	protein histidine kinase activity
K4756_16295	COG2770	Histidine kinase
K4756_16305	COG1309	transcriptional regulator
K4756_16310	COG0114	fumarate hydratase activity
K4756_16325	COG0814	amino acid
K4756_16335	COG2197	response regulator
K4756_16340	COG4585	Histidine kinase
K4756_16345	COG4758	membrane
K4756_16350	COG3595	metallopeptidase activity
K4756_16355	COG1842	Phage shock protein A
K4756_16360	COG4758	membrane
K4756_16365	COG2814	Major facilitator Superfamily
K4756_16370	COG2096	Adenosyltransferase
K4756_16375	COG1120	ATPase activity
K4756_16380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_16385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4756_16390	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_16395	COG3386	PFAM SMP-30 Gluconolaconase
K4756_16400	COG2205	protein histidine kinase activity
K4756_16405	COG0745	RESPONSE REGULATOR receiver
K4756_16415	COG1191	sigma factor activity
K4756_16425	COG2140	Oxalate decarboxylase
K4756_16435	COG0577	efflux transmembrane transporter activity
K4756_16440	COG1136	(ABC) transporter
K4756_16445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K4756_16450	COG1120	ATPase activity
K4756_16455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_16460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4756_16465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4756_16470	COG0531	amino acid
K4756_16480	COG1988	membrane-bound metal-dependent
K4756_16485	COG1368	sulfuric ester hydrolase activity
K4756_16490	COG1910	domain protein
K4756_16495	COG0725	ABC transporter, periplasmic molybdate-binding protein
K4756_16500	COG4149	molybdate abc transporter
K4756_16505	COG0656	L-ascorbic acid biosynthetic process
K4756_16515	COG0025	NhaP-type Na H and K H
K4756_16520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K4756_16525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K4756_16530	COG3973	AAA domain
K4756_16540	COG2860	membrane
K4756_16545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K4756_16550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K4756_16555	COG2217	Heavy metal translocating P-type atpase
K4756_16560	COG2217	Heavy metal translocating P-type atpase
K4756_16565	COG2608	mercury ion transmembrane transporter activity
K4756_16570	COG1937	Protein conserved in bacteria
K4756_16575	COG0673	inositol 2-dehydrogenase activity
K4756_16580	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K4756_16585	COG1289	transmembrane transporter activity
K4756_16595	COG2076	Multidrug Resistance protein
K4756_16600	COG1309	transcriptional regulator
K4756_16605	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_16615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K4756_16620	COG0557	exoribonuclease II activity
K4756_16625	COG1647	Serine aminopeptidase, S33
K4756_16630	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K4756_16635	COG0596	Alpha beta hydrolase
K4756_16640	COG1476	TRANSCRIPTIONal
K4756_16645	COG1396	sequence-specific DNA binding
K4756_16650	COG1396	sequence-specific DNA binding
K4756_16655	COG1733	regulation of RNA biosynthetic process
K4756_16680	COG1174	glycine betaine transport
K4756_16685	COG1732	Glycine betaine
K4756_16690	COG1174	glycine betaine transport
K4756_16695	COG0517	IMP dehydrogenase activity
K4756_16695	COG1125	glycine betaine transport
K4756_16700	COG1510	regulation of RNA biosynthetic process
K4756_16705	COG1174	glycine betaine transport
K4756_16710	COG1732	Glycine betaine
K4756_16715	COG1174	glycine betaine transport
K4756_16720	COG0517	IMP dehydrogenase activity
K4756_16720	COG1125	glycine betaine transport
K4756_16725	COG1510	regulation of RNA biosynthetic process
K4756_16730	COG2095	MarC family integral membrane protein
K4756_16740	COG3064	Membrane
K4756_16745	COG4640	response to antibiotic
K4756_16750	COG0456	acetyltransferase
K4756_16765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K4756_16785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4756_16790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K4756_16800	COG2234	aminopeptidase activity
K4756_16805	COG0148	phosphopyruvate hydratase activity
K4756_16810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K4756_16815	COG0149	triose-phosphate isomerase activity
K4756_16820	COG0126	phosphoglycerate kinase activity
K4756_16825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K4756_16830	COG2390	Transcriptional regulator
K4756_16835	COG2814	Major facilitator Superfamily
K4756_16840	COG1609	Transcriptional regulator
K4756_16845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4756_16850	COG0583	DNA-binding transcription factor activity
K4756_16855	COG0697	spore germination
K4756_16860	COG1113	amino acid transport
K4756_16865	COG3858	chitin binding
K4756_16870	COG1556	Lactate utilization protein
K4756_16875	COG1139	Iron-sulfur cluster binding protein
K4756_16880	COG0247	lactate metabolic process
K4756_16885	COG2197	response regulator
K4756_16890	COG4585	Histidine kinase
K4756_16895	COG0842	Transport permease protein
K4756_16900	COG1131	(ABC) transporter
K4756_16905	COG0596	Alpha beta hydrolase
K4756_16910	COG2208	phosphoserine phosphatase activity
K4756_16915	COG3867	Arabinogalactan endo-beta-1,4-galactanase
K4756_16920	COG1874	Beta-galactosidase
K4756_16925	COG3833	ABC-type maltose transport systems, permease component
K4756_16930	COG1175	transmembrane transport
K4756_16935	COG2182	Extracellular solute-binding protein
K4756_16940	COG1609	Transcriptional regulator
K4756_16945	COG2186	Transcriptional regulator
K4756_16950	COG1620	l-lactate permease
K4756_16955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K4756_16965	COG5039	Polysaccharide pyruvyl transferase
K4756_16970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K4756_16975	COG0110	maltose O-acetyltransferase activity
K4756_16980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K4756_16985	COG2244	polysaccharide biosynthetic process
K4756_16990	COG1216	Glycosyl transferase, family 2
K4756_17000	COG1216	Glycosyl transferase, family 2
K4756_17010	COG0438	transferase activity, transferring glycosyl groups
K4756_17015	COG1215	transferase activity, transferring glycosyl groups
K4756_17020	COG0438	transferase activity, transferring glycosyl groups
K4756_17025	COG1086	Polysaccharide biosynthesis protein
K4756_17030	COG0489	protein tyrosine kinase activity
K4756_17035	COG3944	biosynthesis protein
K4756_17040	COG1396	sequence-specific DNA binding
K4756_17045	COG2272	Belongs to the type-B carboxylesterase lipase family
K4756_17055	COG3479	Phenolic acid decarboxylase
K4756_17065	COG1794	racemase activity, acting on amino acids and derivatives
K4756_17080	COG1621	beta-fructofuranosidase activity
K4756_17085	COG1621	beta-fructofuranosidase activity
K4756_17090	COG0531	amino acid
K4756_17095	COG1309	transcriptional regulator
K4756_17100	COG2076	Multidrug Resistance protein
K4756_17105	COG2076	Multidrug Resistance protein
K4756_17145	COG0740	serine-type endopeptidase activity
K4756_17150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K4756_17155	COG0366	Alpha amylase catalytic
K4756_17165	COG1554	hydrolase, family 65, central catalytic
K4756_17170	COG5521	maltodextrose utilization protein MalA
K4756_17175	COG3833	ABC-type maltose transport systems, permease component
K4756_17180	COG1175	transmembrane transport
K4756_17185	COG2182	Extracellular solute-binding protein
K4756_17190	COG0366	Alpha amylase catalytic
K4756_17195	COG1609	Transcriptional regulator
K4756_17200	COG1611	Belongs to the LOG family
K4756_17205	COG1694	Mazg nucleotide pyrophosphohydrolase
K4756_17210	COG0659	secondary active sulfate transmembrane transporter activity
K4756_17215	COG0288	reversible hydration of carbon dioxide
K4756_17220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K4756_17225	COG0577	efflux transmembrane transporter activity
K4756_17230	COG1136	(ABC) transporter
K4756_17235	COG5002	protein histidine kinase activity
K4756_17240	COG0745	RESPONSE REGULATOR receiver
K4756_17250	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K4756_17255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4756_17260	COG1481	regulation of sporulation
K4756_17265	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K4756_17270	COG1660	Displays ATPase and GTPase activities
K4756_17275	COG1051	belongs to the nudix hydrolase family
K4756_17280	COG0492	ferredoxin-NADP+ reductase activity
K4756_17285	COG3883	PFAM NLP P60 protein
K4756_17285	COG0791	NLP P60 protein
K4756_17290	COG0457	Tetratricopeptide repeat
K4756_17295	COG1132	(ABC) transporter
K4756_17315	COG0140	phosphoribosyl-ATP diphosphatase activity
K4756_17315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K4756_17320	COG0107	imidazoleglycerol-phosphate synthase activity
K4756_17325	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K4756_17330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K4756_17335	COG0131	Imidazoleglycerol-phosphate dehydratase
K4756_17340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K4756_17345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K4756_17350	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K4756_17355	COG4990	cell redox homeostasis
K4756_17360	COG5297	Belongs to the glycosyl hydrolase family 6
K4756_17365	COG0110	maltose O-acetyltransferase activity
K4756_17370	COG0546	phosphoglycolate phosphatase activity
K4756_17375	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K4756_17380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K4756_17385	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K4756_17390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K4756_17395	COG0363	glucosamine-6-phosphate deaminase activity
K4756_17400	COG2188	Transcriptional regulator
K4756_17405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K4756_17410	COG1950	PFAM Membrane protein of
K4756_17415	COG1983	PspC domain protein
K4756_17420	COG3595	metallopeptidase activity
K4756_17435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K4756_17440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K4756_17445	COG0556	nucleotide-excision repair
K4756_17450	COG4897	Protein conserved in bacteria
K4756_17455	COG0574	Belongs to the PEP-utilizing enzyme family
K4756_17455	COG3848	Pyruvate phosphate dikinase
K4756_17460	COG1309	transcriptional regulator
K4756_17465	COG2814	Major facilitator Superfamily
K4756_17470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4756_17480	COG3409	Peptidoglycan-binding domain 1 protein
K4756_17480	COG0793	Belongs to the peptidase S41A family
K4756_17485	COG2177	Part of the ABC transporter FtsEX involved in
K4756_17490	COG2884	Cell division ATP-binding protein ftsE
K4756_17495	COG2010	Cytochrome c
K4756_17500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4756_17510	COG0653	protein targeting
K4756_17515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K4756_17530	COG1516	flagellar protein fliS
K4756_17535	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K4756_17540	COG1334	flagellar protein FlaG
K4756_17545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K4756_17550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K4756_17555	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
K4756_17565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K4756_17570	COG4786	Flagellar basal body rod
K4756_17570	COG1256	bacterial-type flagellum assembly
K4756_17575	COG3418	PFAM FlgN family protein
K4756_17580	COG2747	anti-sigma28 factor FlgM
K4756_17590	COG1040	competence protein
K4756_17600	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K4756_17605	COG1307	EDD domain protein, DegV family
K4756_17610	COG2197	response regulator
K4756_17615	COG4585	Histidine kinase
K4756_17620	COG1739	Uncharacterized protein family UPF0029
K4756_17625	COG1316	TRANSCRIPTIONal
K4756_17630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K4756_17635	COG0438	transferase activity, transferring glycosyl groups
K4756_17640	COG1215	transferase activity, transferring glycosyl groups
K4756_17645	COG3206	protein involved in exopolysaccharide biosynthesis
K4756_17650	COG3307	-O-antigen
K4756_17655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K4756_17660	COG0297	glycogen (starch) synthase activity
K4756_17660	COG0438	transferase activity, transferring glycosyl groups
K4756_17665	COG2244	polysaccharide biosynthetic process
K4756_17680	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4756_17680	COG2247	cell wall binding repeat
K4756_17685	COG2247	cell wall binding repeat
K4756_17685	COG2385	sporulation resulting in formation of a cellular spore
K4756_17695	COG1316	TRANSCRIPTIONal
K4756_17700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K4756_17720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K4756_17725	COG1134	teichoic acid transport
K4756_17730	COG1682	transport, permease protein
K4756_17750	COG0463	Glycosyl transferase, family 2
K4756_17795	COG4193	domain, Protein
K4756_17800	COG1482	cell wall glycoprotein biosynthetic process
K4756_17805	COG0697	spore germination
K4756_17810	COG0814	amino acid
K4756_17820	COG2814	Major facilitator Superfamily
K4756_17825	COG1316	TRANSCRIPTIONal
K4756_17830	COG0561	phosphatase activity
K4756_17835	COG0791	NLP P60 protein
K4756_17845	COG2843	Capsule synthesis protein
K4756_17855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K4756_17860	COG1609	Transcriptional regulator
K4756_17865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4756_17870	COG1869	D-ribose catabolic process
K4756_17875	COG1129	ABC transporter
K4756_17880	COG1172	Belongs to the binding-protein-dependent transport system permease family
K4756_17885	COG1879	ABC-type sugar transport system periplasmic component
K4756_17890	COG3103	Sh3 type 3 domain protein
K4756_17900	COG2249	NAD(P)H dehydrogenase (quinone) activity
K4756_17905	COG3527	Alpha-acetolactate decarboxylase
K4756_17910	COG0028	Belongs to the TPP enzyme family
K4756_17915	COG0583	DNA-binding transcription factor activity
K4756_17920	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K4756_17935	COG5337	Spore coat protein CotH
K4756_17945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K4756_17955	COG0405	Gamma-glutamyltransferase
K4756_17960	COG1522	sequence-specific DNA binding
K4756_17965	COG2059	Chromate
K4756_17970	COG2059	Chromate
K4756_18000	COG5444	nuclease activity
K4756_18015	COG3878	Protein conserved in bacteria
K4756_18020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K4756_18025	COG4464	protein tyrosine phosphatase activity
K4756_18030	COG0489	protein tyrosine kinase activity
K4756_18035	COG3944	biosynthesis protein
K4756_18045	COG4715	Zinc finger, swim domain protein
K4756_18050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K4756_18055	COG0561	phosphatase activity
K4756_18060	COG1349	DNA-binding transcription factor activity
K4756_18065	COG0629	single-stranded DNA binding
K4756_18080	COG3764	Sortase (surface protein transpeptidase)
K4756_18090	COG3279	Response regulator of the LytR AlgR family
K4756_18095	COG0745	RESPONSE REGULATOR receiver
K4756_18095	COG2972	Histidine kinase
K4756_18100	COG1970	mechanosensitive ion channel activity
K4756_18105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K4756_18110	COG0457	Tetratricopeptide repeat
K4756_18115	COG4786	Flagellar basal body rod
K4756_18120	COG4786	Flagellar basal body rod
K4756_18125	COG1077	Cell shape determining protein MreB Mrl
K4756_18130	COG1609	Transcriptional regulator
K4756_18140	COG1846	Transcriptional regulator
K4756_18145	COG2814	Major facilitator Superfamily
K4756_18150	COG3420	alginic acid biosynthetic process
K4756_18155	COG1953	Uracil, thiamine, allantoin
K4756_18160	COG0477	Major facilitator Superfamily
K4756_18165	COG1335	isochorismatase
K4756_18175	COG0004	ammonium transporteR
K4756_18180	COG0347	Belongs to the P(II) protein family
K4756_18185	COG0671	phosphoesterase, PA-phosphatase related
K4756_18195	COG0739	heme binding
K4756_18200	COG1247	-acetyltransferase
K4756_18210	COG2089	acid synthase
K4756_18220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4756_18225	COG0789	Transcriptional regulator
K4756_18235	COG2910	NAD(P)H-binding
K4756_18240	COG1959	2 iron, 2 sulfur cluster binding
K4756_18245	COG0804	urea catabolic process
K4756_18250	COG0832	Belongs to the urease beta subunit family
K4756_18255	COG0831	urea catabolic process
K4756_18270	COG3237	CsbD-like
K4756_18275	COG1994	Peptidase M50
K4756_18280	COG0457	Tetratricopeptide repeat
K4756_18285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K4756_18290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K4756_18300	COG2304	oxidoreductase activity
K4756_18310	COG2304	oxidoreductase activity
K4756_18315	COG2385	sporulation resulting in formation of a cellular spore
K4756_18320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K4756_18330	COG4836	Membrane
K4756_18340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K4756_18345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K4756_18350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K4756_18360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K4756_18365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K4756_18375	COG0356	it plays a direct role in the translocation of protons across the membrane
K4756_18385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K4756_18390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K4756_18395	COG4475	Protein of unknown function (DUF436)
K4756_18400	COG0698	ribose 5-phosphate isomerase
K4756_18405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K4756_18410	COG1971	Probably functions as a manganese efflux pump
K4756_18415	COG0009	L-threonylcarbamoyladenylate synthase
K4756_18420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K4756_18440	COG2890	protein-(glutamine-N5) methyltransferase activity
K4756_18445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K4756_18450	COG0346	lactoylglutathione lyase activity
K4756_18455	COG0789	Transcriptional regulator
K4756_18460	COG0679	Auxin Efflux Carrier
K4756_18465	COG0281	malic enzyme
K4756_18470	COG1435	thymidine kinase activity
K4756_18480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K4756_18490	COG1494	fructose-1,6-bisphosphatase
K4756_18495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K4756_18500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K4756_18505	COG0191	fructose-bisphosphate aldolase activity
K4756_18510	COG2204	response regulator
K4756_18515	COG4821	SIS domain
K4756_18520	COG0504	CTP synthase activity
K4756_18525	COG3343	RNA polymerase activity
K4756_18530	COG1960	acyl-CoA dehydrogenase activity
K4756_18535	COG2181	nitrate reductase activity
K4756_18535	COG0247	lactate metabolic process
K4756_18540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4756_18545	COG4294	response to UV
K4756_18555	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K4756_18560	COG1132	(ABC) transporter
K4756_18565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4756_18570	COG2181	nitrate reductase activity
K4756_18575	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
K4756_18580	COG1140	nitrate reductase beta subunit
K4756_18585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K4756_18590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K4756_18600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K4756_18605	COG2223	nitrite transmembrane transporter activity
K4756_18610	COG0018	arginyl-trna synthetase
K4756_18615	COG4506	Protein conserved in bacteria
K4756_18630	COG0535	radical SAM domain protein
K4756_18640	COG1131	(ABC) transporter
K4756_18645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K4756_18650	COG0612	Peptidase, M16
K4756_18655	COG0612	Peptidase, M16
K4756_18665	COG3391	amine dehydrogenase activity
K4756_18670	COG3391	amine dehydrogenase activity
K4756_18675	COG0457	Tetratricopeptide repeat
K4756_18695	COG1131	(ABC) transporter
K4756_18705	COG0010	Belongs to the arginase family
K4756_18710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K4756_18715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4756_18725	COG1994	Peptidase M50
K4756_18730	COG1942	4-Oxalocrotonate Tautomerase
K4756_18735	COG1846	Transcriptional regulator
K4756_18740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K4756_18750	COG0477	Major facilitator Superfamily
K4756_18755	COG1959	2 iron, 2 sulfur cluster binding
K4756_18760	COG3465	dGTPase activity
K4756_18765	COG1078	dGTPase activity
K4756_18770	COG4844	belongs to the
K4756_18780	COG0697	spore germination
K4756_18785	COG0095	Lipoate-protein ligase
K4756_18790	COG0583	DNA-binding transcription factor activity
K4756_18795	COG0280	phosphate acetyltransferase
K4756_18800	COG3253	May function as heme-dependent peroxidase
K4756_18805	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_18810	COG0436	Aminotransferase
K4756_18815	COG2814	Major facilitator Superfamily
K4756_18820	COG0151	Belongs to the GarS family
K4756_18825	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_18830	COG1917	Cupin 2, conserved barrel domain protein
K4756_18835	COG0077	Prephenate dehydratase
K4756_18840	COG2814	Major facilitator Superfamily
K4756_18845	COG0833	amino acid
K4756_18850	COG4187	Peptidase family M20/M25/M40
K4756_18855	COG1012	belongs to the aldehyde dehydrogenase family
K4756_18860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K4756_18870	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K4756_18875	COG1091	dTDP-4-dehydrorhamnose reductase activity
K4756_18880	COG1088	dTDP-glucose 4,6-dehydratase activity
K4756_18885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K4756_18890	COG3980	spore coat polysaccharide biosynthesis protein
K4756_18895	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
K4756_18900	COG2089	acid synthase
K4756_18905	COG0456	acetyltransferase
K4756_18910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K4756_18915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K4756_18920	COG0463	Glycosyl transferase, family 2
K4756_18930	COG2363	Small membrane protein
K4756_18935	COG2233	PERMEase
K4756_18945	COG1012	belongs to the aldehyde dehydrogenase family
K4756_18950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K4756_18955	COG1216	Glycosyl transferase, family 2
K4756_18960	COG0351	phosphomethylpyrimidine kinase
K4756_18970	COG1621	beta-fructofuranosidase activity
K4756_18975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_18975	COG1263	PTS System
K4756_18985	COG3711	transcriptional antiterminator
K4756_18995	COG1404	Belongs to the peptidase S8 family
K4756_19000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4756_19005	COG0778	Nitroreductase
K4756_19010	COG0772	Belongs to the SEDS family
K4756_19020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K4756_19025	COG1845	cytochrome c oxidase, subunit III
K4756_19030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K4756_19035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K4756_19040	COG2261	transglycosylase associated protein
K4756_19045	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K4756_19050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K4756_19055	COG2246	polysaccharide biosynthetic process
K4756_19060	COG1309	transcriptional regulator
K4756_19070	COG3162	membrane
K4756_19075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4756_19080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K4756_19085	COG2837	iron assimilation
K4756_19090	COG2822	iron ion transport
K4756_19095	COG0672	)-iron permease
K4756_19100	COG0352	thiamine-phosphate diphosphorylase activity
K4756_19105	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K4756_19110	COG0583	DNA-binding transcription factor activity
K4756_19115	COG1380	Effector of murein hydrolase LrgA
K4756_19120	COG1346	cytolysis
K4756_19125	COG2814	Major facilitator Superfamily
K4756_19130	COG4895	conserved protein (DUF2196)
K4756_19135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K4756_19140	COG0346	lactoylglutathione lyase activity
K4756_19150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4756_19155	COG1404	Belongs to the peptidase S8 family
K4756_19160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_19160	COG1263	PTS System
K4756_19165	COG3711	transcriptional antiterminator
K4756_19170	COG1442	glycosyl transferase family 8
K4756_19175	COG5522	Integral membrane protein (intg_mem_TP0381)
K4756_19180	COG1846	Transcriptional regulator
K4756_19185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K4756_19190	COG2234	aminopeptidase activity
K4756_19195	COG2357	RelA SpoT domain protein
K4756_19200	COG1575	Belongs to the MenA family. Type 1 subfamily
K4756_19215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4756_19220	COG1696	Membrane protein involved in D-alanine export
K4756_19225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K4756_19230	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K4756_19235	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
K4756_19240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K4756_19245	COG1486	melibiose metabolic process
K4756_19250	COG1447	Phosphotransferase system cellobiose-specific component IIA
K4756_19255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4756_19260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4756_19265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4756_19265	COG3711	transcriptional antiterminator
K4756_19275	COG2094	Belongs to the DNA glycosylase MPG family
K4756_19280	COG0753	catalase activity
K4756_19285	COG2814	Major facilitator Superfamily
K4756_19290	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K4756_19295	COG1131	(ABC) transporter
K4756_19315	COG1595	DNA-templated transcription, initiation
K4756_19320	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K4756_19325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K4756_19330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K4756_19335	COG4988	ABC transporter
K4756_19340	COG1294	oxidase, subunit
K4756_19345	COG1271	oxidase subunit
K4756_19350	COG3493	citrate carrier protein
K4756_19355	COG0501	Belongs to the peptidase M48B family
K4756_19365	COG0726	polysaccharide deacetylase
K4756_19370	COG3842	ATPase activity
K4756_19375	COG2508	Transcriptional regulator
K4756_19380	COG1012	belongs to the aldehyde dehydrogenase family
K4756_19385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4756_19395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K4756_19400	COG1881	PFAM PEBP family protein
K4756_19405	COG0583	DNA-binding transcription factor activity
K4756_19415	COG4585	Histidine kinase
K4756_19420	COG2197	response regulator
K4756_19425	COG2195	Cleaves the N-terminal amino acid of tripeptides
K4756_19435	COG4894	glucomannan catabolic process
K4756_19440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K4756_19445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K4756_19450	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_19455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K4756_19460	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K4756_19465	COG2610	gluconate transmembrane transporter activity
K4756_19470	COG0500	methyltransferase
K4756_19475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K4756_19490	COG0693	protein deglycase activity
K4756_19490	COG0753	catalase activity
K4756_19495	COG2851	Citrate transporter
K4756_19500	COG2273	Hydrolase Family 16
K4756_19505	COG3711	transcriptional antiterminator
K4756_19515	COG2270	Major facilitator Superfamily
K4756_19520	COG0513	Belongs to the DEAD box helicase family
K4756_19525	COG3401	FG-GAP repeat protein
K4756_19525	COG2755	lipolytic protein G-D-S-L family
K4756_19545	COG0697	spore germination
K4756_19550	COG0589	response to stress
K4756_19555	COG2723	6-phospho-beta-galactosidase activity
K4756_19560	COG1263	PTS System
K4756_19560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4756_19560	COG2190	(PTS) system
K4756_19610	COG5444	nuclease activity
K4756_19635	COG0494	nUDIX hydrolase
K4756_19640	COG3507	Belongs to the glycosyl hydrolase 43 family
K4756_19655	COG2986	histidine ammonia-lyase
K4756_19660	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K4756_19665	COG1228	amidohydrolase
K4756_19670	COG0010	Belongs to the arginase family
K4756_19680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K4756_19685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K4756_19690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K4756_19695	COG2390	Transcriptional regulator
K4756_19705	COG3192	ethanolamine utilization protein
K4756_19710	COG2079	MmgE PrpD family protein
K4756_19715	COG1473	amidohydrolase
K4756_19720	COG1126	abc transporter atp-binding protein
K4756_19725	COG0765	amino acid transport
K4756_19730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4756_19735	COG0456	acetyltransferase
K4756_19740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4756_19745	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K4756_19750	COG0561	phosphatase activity
K4756_19780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4756_19785	COG5294	Protein conserved in bacteria
K4756_19790	COG0577	efflux transmembrane transporter activity
K4756_19795	COG1136	(ABC) transporter
K4756_19800	COG2205	protein histidine kinase activity
K4756_19805	COG0745	RESPONSE REGULATOR receiver
K4756_19810	COG0191	fructose-bisphosphate aldolase activity
K4756_19815	COG1082	Xylose isomerase domain protein TIM barrel
K4756_19820	COG1082	Xylose isomerase domain protein TIM barrel
K4756_19825	COG0673	inositol 2-dehydrogenase activity
K4756_19830	COG2814	Major facilitator Superfamily
K4756_19835	COG1082	Xylose isomerase domain protein TIM barrel
K4756_19840	COG3962	Belongs to the TPP enzyme family
K4756_19845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4756_19855	COG1012	belongs to the aldehyde dehydrogenase family
K4756_19860	COG1349	DNA-binding transcription factor activity
K4756_19865	COG0667	Aldo Keto reductase
K4756_19880	COG2814	Major facilitator Superfamily
K4756_19885	COG0326	Molecular chaperone. Has ATPase activity
K4756_19895	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_19900	COG1309	transcriptional regulator
K4756_19905	COG1012	belongs to the aldehyde dehydrogenase family
K4756_19910	COG1714	RDD family
K4756_19915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K4756_19925	COG1714	RDD family
K4756_19930	COG2311	Membrane
K4756_19935	COG1917	Cupin 2, conserved barrel domain protein
K4756_19940	COG1309	transcriptional regulator
K4756_19945	COG1028	Short-chain dehydrogenase reductase Sdr
K4756_19950	COG1846	Transcriptional regulator
K4756_19955	COG1380	Effector of murein hydrolase LrgA
K4756_19960	COG1346	cytolysis
K4756_19965	COG5039	Polysaccharide pyruvyl transferase
K4756_19970	COG1929	Belongs to the glycerate kinase type-1 family
K4756_19975	COG1802	Transcriptional regulator
K4756_19980	COG1070	Carbohydrate kinase
K4756_19985	COG2610	gluconate transmembrane transporter activity
K4756_19990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K4756_19995	COG0450	alkyl hydroperoxide reductase
K4756_20000	COG3634	alkyl hydroperoxide reductase activity
K4756_20010	COG2723	6-phospho-beta-galactosidase activity
K4756_20025	COG2188	Transcriptional regulator
K4756_20040	COG1131	(ABC) transporter
K4756_20045	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K4756_20055	COG2189	Belongs to the N(4) N(6)-methyltransferase family
K4756_20070	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K4756_20085	COG1063	alcohol dehydrogenase
K4756_20105	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
K4756_20110	COG0456	acetyltransferase
K4756_20115	COG0457	Tetratricopeptide repeat
K4756_20125	COG0010	Belongs to the arginase family
K4756_20130	COG0833	amino acid
K4756_20135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K4756_20140	COG3829	transcription factor binding
K4756_20155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4756_20160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K4756_20165	COG4853	Protein conserved in bacteria
K4756_20170	COG4863	YycH protein
K4756_20175	COG5002	protein histidine kinase activity
K4756_20180	COG0745	RESPONSE REGULATOR receiver
K4756_20210	COG0346	lactoylglutathione lyase activity
K4756_20215	COG0305	Participates in initiation and elongation during chromosome replication
K4756_20230	COG3093	addiction module antidote protein HigA
K4756_20235	COG2807	transmembrane transport
K4756_20240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K4756_20245	COG0359	binds to the 23S rRNA
K4756_20250	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
K4756_20255	COG4241	membrane
K4756_20265	COG5577	PFAM Coat F domain
K4756_20270	COG1733	regulation of RNA biosynthetic process
K4756_20275	COG1227	inorganic diphosphatase activity
K4756_20290	COG2271	Major facilitator Superfamily
K4756_20295	COG4978	Transcriptional regulator
K4756_20295	COG0789	Transcriptional regulator
K4756_20305	COG4319	ketosteroid isomerase
K4756_20310	COG1357	PFAM Pentapeptide repeats (8 copies)
K4756_20315	COG2814	Major facilitator Superfamily
K4756_20320	COG0583	DNA-binding transcription factor activity
K4756_20325	COG2153	protein acetylation
K4756_20335	COG0583	DNA-binding transcription factor activity
K4756_20350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4756_20355	COG1846	Transcriptional regulator
K4756_20360	COG2153	protein acetylation
K4756_20365	COG2364	Membrane
K4756_20370	COG0456	acetyltransferase
K4756_20375	COG2315	Protein conserved in bacteria
K4756_20380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K4756_20385	COG1331	Highly conserved protein containing a thioredoxin domain
K4756_20390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K4756_20395	COG0798	PFAM Bile acid sodium symporter
K4756_20400	COG0346	lactoylglutathione lyase activity
K4756_20405	COG0640	Transcriptional regulator
K4756_20415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K4756_20420	COG1331	Highly conserved protein containing a thioredoxin domain
K4756_20425	COG0863	Belongs to the N(4) N(6)-methyltransferase family
K4756_20435	COG1331	Highly conserved protein containing a thioredoxin domain
K4756_20440	COG1266	CAAX protease self-immunity
K4756_20445	COG0477	Major facilitator Superfamily
K4756_20445	COG2814	Major facilitator Superfamily
K4756_20450	COG0110	maltose O-acetyltransferase activity
K4756_20455	COG0346	lactoylglutathione lyase activity
K4756_20460	COG1609	Transcriptional regulator
K4756_20465	COG0708	Exodeoxyribonuclease III
K4756_20470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K4756_20475	COG0629	single-stranded DNA binding
K4756_20480	COG0360	Binds together with S18 to 16S ribosomal RNA
K4756_20485	COG0012	GTP binding
K4756_20490	COG0243	molybdopterin cofactor binding
K4756_20495	COG4481	Protein conserved in bacteria
K4756_20500	COG3949	Membrane
K4756_20510	COG1475	DNA binding
K4756_20515	COG1192	Involved in chromosome partitioning
K4756_20525	COG1475	DNA binding
K4756_20530	COG0357	Ribosomal RNA small subunit methyltransferase G
K4756_20535	COG0445	tRNA wobble uridine modification
K4756_20540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K4756_20545	COG1847	R3H domain protein
K4756_20550	COG0706	membrane insertase activity
K4756_20555	COG0594	ribonuclease P activity