locus-tag	class	description
I653_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I653_00010	COG0592	DNA-directed DNA polymerase activity
I653_00015	COG2501	S4 domain
I653_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I653_00030	COG0187	DNA topoisomerase II activity
I653_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I653_00045	COG0516	GMP reductase activity
I653_00045	COG0517	IMP dehydrogenase activity
I653_00050	COG1686	Belongs to the peptidase S11 family
I653_00055	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I653_00060	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I653_00065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I653_00070	COG1428	Deoxynucleoside kinase
I653_00075	COG1428	Deoxynucleoside kinase
I653_00080	COG3858	chitin binding
I653_00080	COG1388	LysM domain
I653_00085	COG1335	isochorismatase
I653_00090	COG0590	tRNA wobble adenosine to inosine editing
I653_00095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I653_00100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I653_00105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I653_00125	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I653_00130	COG3853	Toxic anion resistance protein (TelA)
I653_00135	COG1982	Orn Lys Arg decarboxylase major
I653_00140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I653_00145	COG3870	Protein conserved in bacteria
I653_00150	COG1728	Protein conserved in bacteria
I653_00155	COG0470	DNA polymerase III
I653_00160	COG1774	PSP1 C-terminal conserved region
I653_00165	COG4467	Involved in initiation control of chromosome replication
I653_00170	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I653_00175	COG2827	Endonuclease containing a URI domain
I653_00180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I653_00185	COG2002	toxin-antitoxin pair type II binding
I653_00190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I653_00190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I653_00195	COG0084	hydrolase, TatD family'
I653_00200	COG3583	domain protein
I653_00200	COG3584	3D domain protein
I653_00205	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I653_00210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I653_00220	COG4466	Protein conserved in bacteria
I653_00230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I653_00235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I653_00240	COG0251	oxidation-reduction process
I653_00245	COG2088	sporulation resulting in formation of a cellular spore
I653_00250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I653_00255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I653_00260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I653_00265	COG0193	aminoacyl-tRNA hydrolase activity
I653_00275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I653_00280	COG2002	toxin-antitoxin pair type II binding
I653_00285	COG2244	polysaccharide biosynthetic process
I653_00290	COG3956	TIGRFAM MazG family protein
I653_00295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I653_00310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I653_00315	COG1098	S1 RNA binding domain
I653_00320	COG2208	phosphoserine phosphatase activity
I653_00325	COG2304	oxidoreductase activity
I653_00330	COG0515	serine threonine protein kinase
I653_00335	COG0037	tRNA processing
I653_00345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I653_00350	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I653_00355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I653_00360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I653_00365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I653_00370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I653_00375	COG0512	Glutamine amidotransferase of anthranilate synthase
I653_00380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I653_00385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I653_00390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I653_00395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I653_00400	COG1396	sequence-specific DNA binding
I653_00405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I653_00410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I653_00415	COG4463	regulation of RNA biosynthetic process
I653_00420	COG3880	PFAM UvrB UvrC protein
I653_00425	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I653_00430	COG0542	response to heat
I653_00435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I653_00440	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I653_00445	COG4956	integral membrane protein (PIN domain superfamily)
I653_00450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I653_00455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I653_00460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I653_00470	COG1045	serine acetyltransferase
I653_00475	COG0215	cysteine-tRNA ligase activity
I653_00480	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I653_00485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I653_00490	COG3688	RNA-binding protein containing a PIN domain
I653_00495	COG1595	DNA-templated transcription, initiation
I653_00500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I653_00505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I653_00510	COG0250	Participates in transcription elongation, termination and antitermination
I653_00515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I653_00520	COG0081	regulation of translation
I653_00525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I653_00530	COG0222	ribosome binding
I653_00535	COG2813	Specifically methylates the guanine in position
I653_00540	COG0085	RNA polymerase activity
I653_00545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I653_00550	COG1358	cellular component organization or biogenesis
I653_00555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I653_00560	COG0049	tRNA binding
I653_00565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I653_00570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I653_00575	COG0596	Alpha beta hydrolase
I653_00580	COG0051	transcription antitermination factor activity, RNA binding
I653_00585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I653_00590	COG0088	Forms part of the polypeptide exit tunnel
I653_00595	COG0089	rRNA binding
I653_00600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I653_00605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I653_00610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I653_00615	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I653_00620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I653_00625	COG0255	Belongs to the universal ribosomal protein uL29 family
I653_00630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I653_00635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I653_00645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I653_00655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I653_00660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I653_00665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I653_00670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I653_00675	COG1841	ribosomal large subunit assembly
I653_00680	COG0200	Binds to the 23S rRNA
I653_00685	COG0201	protein transport
I653_00690	COG0563	adenylate kinase activity
I653_00695	COG0024	Methionine aminopeptidase
I653_00700	COG2163	COG2163 Ribosomal protein L14E L6E L27E
I653_00705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I653_00710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I653_00715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I653_00720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I653_00725	COG0202	RNA polymerase activity
I653_00730	COG0203	ribosomal protein L17
I653_00735	COG1122	ATPase activity
I653_00740	COG1122	ATPase activity
I653_00745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I653_00750	COG0101	tRNA pseudouridine synthase activity
I653_00755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I653_00760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I653_00765	COG2226	methyltransferase
I653_00775	COG0860	N-Acetylmuramoyl-L-alanine amidase
I653_00780	COG0489	protein tyrosine kinase activity
I653_00790	COG2194	sulfuric ester hydrolase activity
I653_00795	COG0726	polysaccharide deacetylase
I653_00800	COG0659	secondary active sulfate transmembrane transporter activity
I653_00805	COG0385	Bile acid
I653_00810	COG2819	hydrolase of the alpha beta superfamily
I653_00815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_00820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_00825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I653_00830	COG2207	Transcriptional regulator
I653_00830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I653_00835	COG3876	Protein conserved in bacteria
I653_00840	COG1472	Belongs to the glycosyl hydrolase 3 family
I653_00845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I653_00850	COG1263	PTS System
I653_00850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_00855	COG1737	Transcriptional regulator
I653_00860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I653_00865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I653_00870	COG1683	Conserved Protein
I653_00880	COG1595	DNA-templated transcription, initiation
I653_00885	COG5662	AntiSigma factor
I653_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I653_00895	COG4856	YbbR-like protein
I653_00900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I653_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I653_00920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I653_00925	COG3002	Belongs to the UPF0753 family
I653_00930	COG0288	reversible hydration of carbon dioxide
I653_00940	COG5609	conserved protein (DUF2294)
I653_00945	COG0640	Transcriptional regulator
I653_00950	COG2814	Major facilitator Superfamily
I653_00965	COG0596	Alpha beta hydrolase
I653_00970	COG0745	RESPONSE REGULATOR receiver
I653_00975	COG0642	Histidine kinase
I653_00985	COG0515	serine threonine protein kinase
I653_01000	COG1113	amino acid transport
I653_01015	COG2602	Beta-lactamase
I653_01020	COG2124	cytochrome p450
I653_01030	COG0531	amino acid
I653_01035	COG0584	glycerophosphoryl diester phosphodiesterase
I653_01040	COG2271	Major facilitator Superfamily
I653_01050	COG1846	Transcriptional regulator
I653_01050	COG0456	acetyltransferase
I653_01055	COG2271	Major facilitator Superfamily
I653_01065	COG0697	spore germination
I653_01070	COG1917	Cupin 2, conserved barrel domain protein
I653_01070	COG2207	Transcriptional regulator
I653_01075	COG1397	ADP-ribosylglycohydrolase
I653_01080	COG5444	nuclease activity
I653_01085	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I653_01090	COG3591	Belongs to the peptidase S1B family
I653_01100	COG0596	Alpha beta hydrolase
I653_01105	COG1183	phosphatidylcholine synthase activity
I653_01110	COG0586	Pfam SNARE associated Golgi protein
I653_01115	COG0688	phosphatidylethanolamine metabolic process
I653_01125	COG2312	Erythromycin esterase
I653_01135	COG1301	dicarboxylic acid transport
I653_01140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_01140	COG2190	(PTS) system
I653_01140	COG1263	PTS System
I653_01145	COG0363	glucosamine-6-phosphate deaminase activity
I653_01160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I653_01165	COG0833	amino acid
I653_01170	COG2040	homocysteine
I653_01180	COG1115	amino acid carrier protein
I653_01185	COG2066	Belongs to the glutaminase family
I653_01190	COG4191	Histidine kinase
I653_01195	COG0784	Response regulator, receiver
I653_01200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I653_01205	COG1012	belongs to the aldehyde dehydrogenase family
I653_01210	COG2271	Major facilitator Superfamily
I653_01215	COG4948	Mandelate Racemase Muconate Lactonizing
I653_01220	COG2186	Transcriptional regulator
I653_01225	COG2721	sulfolactate sulfo-lyase activity
I653_01230	COG3173	Aminoglycoside phosphotransferase
I653_01240	COG0697	spore germination
I653_01245	COG0745	RESPONSE REGULATOR receiver
I653_01250	COG2205	protein histidine kinase activity
I653_01255	COG1131	(ABC) transporter
I653_01275	COG3773	Cell wall hydrolase
I653_01280	COG2304	oxidoreductase activity
I653_01290	COG3540	Alkaline phosphatase
I653_01295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I653_01300	COG0805	protein transport
I653_01305	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I653_01310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I653_01315	COG0477	Major facilitator Superfamily
I653_01320	COG1309	transcriptional regulator
I653_01325	COG0252	asparaginase activity
I653_01330	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I653_01335	COG1714	RDD family
I653_01340	COG3012	SEC-C Motif Domain Protein
I653_01340	COG1405	negative regulation of cell septum assembly
I653_01345	COG3290	protein histidine kinase activity
I653_01350	COG3279	Response regulator of the LytR AlgR family
I653_01355	COG4555	ABC transporter
I653_01360	COG1668	transmembrane transport
I653_01365	COG0667	Aldo Keto reductase
I653_01375	COG1595	DNA-templated transcription, initiation
I653_01380	COG1595	DNA-templated transcription, initiation
I653_01385	COG1876	peptidase activity
I653_01390	COG0457	Tetratricopeptide repeat
I653_01395	COG1028	Short-chain dehydrogenase reductase Sdr
I653_01400	COG0366	Alpha amylase catalytic
I653_01405	COG0803	Belongs to the bacterial solute-binding protein 9 family
I653_01410	COG1121	(ABC) transporter
I653_01415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I653_01420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I653_01425	COG2310	stress, protein
I653_01430	COG2310	stress, protein
I653_01435	COG2310	stress, protein
I653_01440	COG0861	Integral membrane protein TerC family
I653_01450	COG3853	Toxic anion resistance protein (TelA)
I653_01455	COG0477	Major facilitator Superfamily
I653_01460	COG2814	Major facilitator Superfamily
I653_01465	COG0640	Transcriptional regulator
I653_01470	COG4175	Glycine betaine
I653_01470	COG0517	IMP dehydrogenase activity
I653_01475	COG4176	ABC-type proline glycine betaine transport system permease component
I653_01480	COG2113	Glycine betaine
I653_01485	COG1473	amidohydrolase
I653_01490	COG1288	antiporter activity
I653_01500	COG0366	Alpha amylase catalytic
I653_01505	COG0039	L-malate dehydrogenase activity
I653_01510	COG1620	l-lactate permease
I653_01515	COG2814	Major facilitator Superfamily
I653_01520	COG1846	Transcriptional regulator
I653_01525	COG1280	lysine exporter protein (LysE YggA)
I653_01530	COG3403	YqcI/YcgG family
I653_01535	COG1113	amino acid transport
I653_01545	COG3665	Urea carboxylase-associated protein
I653_01550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I653_01555	COG1660	Displays ATPase and GTPase activities
I653_01560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I653_01565	COG2226	methyltransferase
I653_01570	COG0583	DNA-binding transcription factor activity
I653_01575	COG3458	cephalosporin-C deacetylase activity
I653_01580	COG3541	Predicted nucleotidyltransferase
I653_01590	COG1012	belongs to the aldehyde dehydrogenase family
I653_01595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I653_01600	COG2508	Transcriptional regulator
I653_01605	COG3689	TIGRFAM TIGR03943 family protein
I653_01610	COG0701	Predicted permease
I653_01615	COG2267	carboxylic ester hydrolase activity
I653_01620	COG0492	ferredoxin-NADP+ reductase activity
I653_01625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I653_01625	COG1587	Uroporphyrinogen-III synthase
I653_01630	COG2146	nitrite reductase [NAD(P)H] activity
I653_01635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I653_01640	COG0243	molybdopterin cofactor binding
I653_01645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I653_01650	COG2223	nitrite transmembrane transporter activity
I653_01655	COG1469	GTP cyclohydrolase I activity
I653_01660	COG1376	ErfK ybiS ycfS ynhG family protein
I653_01670	COG0523	cobalamin synthesis protein
I653_01675	COG0765	amino acid transport
I653_01680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I653_01695	COG1714	RDD family
I653_01705	COG2723	6-phospho-beta-galactosidase activity
I653_01715	COG3209	COG3209 Rhs family protein
I653_01720	COG3290	protein histidine kinase activity
I653_01720	COG0840	transmembrane signaling receptor activity
I653_01725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I653_01730	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I653_01735	COG1733	regulation of RNA biosynthetic process
I653_01770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_01775	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I653_01780	COG2814	Major facilitator Superfamily
I653_01790	COG0697	spore germination
I653_01795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I653_01805	COG2364	Membrane
I653_01810	COG1126	abc transporter atp-binding protein
I653_01815	COG0765	amino acid transport
I653_01820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I653_01825	COG0583	DNA-binding transcription factor activity
I653_01830	COG0163	prenyltransferase activity
I653_01835	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I653_01850	COG0596	Alpha beta hydrolase
I653_01855	COG3104	oligopeptide transport
I653_01860	COG5434	Belongs to the glycosyl hydrolase 28 family
I653_01870	COG0697	spore germination
I653_01880	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I653_01885	COG1136	(ABC) transporter
I653_01890	COG0577	efflux transmembrane transporter activity
I653_01895	COG0745	RESPONSE REGULATOR receiver
I653_01900	COG3850	Histidine kinase
I653_01900	COG5002	protein histidine kinase activity
I653_01905	COG0457	Tetratricopeptide repeat
I653_01925	COG0527	aspartate kinase activity
I653_01930	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_01935	COG4605	iron ion homeostasis
I653_01940	COG4604	ABC transporter, ATP-binding protein
I653_01945	COG4607	ABC-type enterochelin transport system periplasmic component
I653_01950	COG2814	Major facilitator Superfamily
I653_01955	COG1309	transcriptional regulator
I653_01960	COG0778	Nitroreductase
I653_01965	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I653_01970	COG0640	Transcriptional regulator
I653_01975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I653_01980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I653_01985	COG1012	belongs to the aldehyde dehydrogenase family
I653_01995	COG4975	Glucose uptake
I653_02000	COG1028	Short-chain dehydrogenase reductase Sdr
I653_02005	COG4549	nuclear export factor GLE1
I653_02010	COG2372	response to copper ion
I653_02010	COG1276	copper resistance
I653_02015	COG1349	DNA-binding transcription factor activity
I653_02025	COG2213	PTS system mannitol-specific
I653_02030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I653_02035	COG0246	Mannitol dehydrogenase
I653_02040	COG0473	3-isopropylmalate dehydrogenase activity
I653_02045	COG0681	Belongs to the peptidase S26 family
I653_02050	COG0412	Dienelactone hydrolase
I653_02055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I653_02065	COG0561	phosphatase activity
I653_02070	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I653_02075	COG1914	H( )-stimulated, divalent metal cation uptake system
I653_02080	COG4336	lyase activity
I653_02085	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I653_02090	COG1984	allophanate hydrolase subunit 2
I653_02095	COG1414	Transcriptional regulator
I653_02100	COG2755	lipolytic protein G-D-S-L family
I653_02110	COG2329	Antibiotic biosynthesis monooxygenase
I653_02115	COG0768	penicillin binding
I653_02120	COG4989	oxidoreductase activity
I653_02125	COG3711	transcriptional antiterminator
I653_02130	COG0318	PFAM AMP-dependent synthetase and ligase
I653_02135	COG2226	methyltransferase
I653_02140	COG1028	Short-chain dehydrogenase reductase Sdr
I653_02145	COG1917	Cupin 2, conserved barrel domain protein
I653_02150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I653_02155	COG3871	stress protein (general stress protein 26)
I653_02165	COG2814	Major facilitator Superfamily
I653_02170	COG1522	sequence-specific DNA binding
I653_02175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I653_02175	COG0551	DNA topoisomerase type I activity
I653_02180	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I653_02185	COG3706	GGDEF domain
I653_02190	COG5298	Protein conserved in bacteria
I653_02195	COG1215	transferase activity, transferring glycosyl groups
I653_02205	COG0531	amino acid
I653_02210	COG0494	nUDIX hydrolase
I653_02215	COG0028	Belongs to the TPP enzyme family
I653_02225	COG1914	H( )-stimulated, divalent metal cation uptake system
I653_02230	COG2261	transglycosylase associated protein
I653_02235	COG4876	unkown
I653_02240	COG2217	Heavy metal translocating P-type atpase
I653_02245	COG3729	General stress protein
I653_02250	COG0662	Cupin 2, conserved barrel domain protein
I653_02255	COG2329	Antibiotic biosynthesis monooxygenase
I653_02260	COG3546	catalase activity
I653_02265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I653_02270	COG3290	protein histidine kinase activity
I653_02275	COG4565	transcriptional regulatory protein
I653_02280	COG1301	dicarboxylic acid transport
I653_02285	COG0628	permease
I653_02295	COG1131	(ABC) transporter
I653_02300	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I653_02310	COG1960	acyl-CoA dehydrogenase activity
I653_02325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I653_02330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I653_02335	COG1181	Belongs to the D-alanine--D-alanine ligase family
I653_02340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I653_02345	COG0513	Belongs to the DEAD box helicase family
I653_02350	COG3402	PFAM membrane-flanked domain
I653_02355	COG3428	Bacterial PH domain
I653_02360	COG0705	Rhomboid family
I653_02365	COG0736	holo-[acyl-carrier-protein] synthase activity
I653_02370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I653_02375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I653_02380	COG0864	Transcriptional regulator
I653_02385	COG2337	Toxic component of a toxin-antitoxin (TA) module
I653_02390	COG1366	Belongs to the anti-sigma-factor antagonist family
I653_02395	COG1366	Belongs to the anti-sigma-factor antagonist family
I653_02400	COG2172	sigma factor antagonist activity
I653_02405	COG2208	phosphoserine phosphatase activity
I653_02410	COG1366	Belongs to the anti-sigma-factor antagonist family
I653_02415	COG2172	sigma factor antagonist activity
I653_02420	COG1191	sigma factor activity
I653_02425	COG2208	phosphoserine phosphatase activity
I653_02435	COG1673	EVE domain
I653_02440	COG1846	Transcriptional regulator
I653_02445	COG2183	response to ionizing radiation
I653_02455	COG3091	SprT-like family
I653_02465	COG0515	serine threonine protein kinase
I653_02470	COG0515	serine threonine protein kinase
I653_02475	COG1132	(ABC) transporter
I653_02495	COG1476	TRANSCRIPTIONal
I653_02505	COG3239	Fatty acid desaturase
I653_02510	COG1278	Cold shock
I653_02515	COG1329	Transcriptional regulator
I653_02520	COG1917	Cupin 2, conserved barrel domain protein
I653_02520	COG2207	Transcriptional regulator
I653_02525	COG0697	spore germination
I653_02530	COG3708	Transcriptional regulator
I653_02530	COG2207	Transcriptional regulator
I653_02535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I653_02540	COG0477	Major facilitator Superfamily
I653_02550	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I653_02560	COG0697	spore germination
I653_02565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I653_02570	COG2030	dehydratase
I653_02575	COG3545	Serine hydrolase
I653_02580	COG1733	regulation of RNA biosynthetic process
I653_02585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I653_02590	COG1733	regulation of RNA biosynthetic process
I653_02595	COG2249	NAD(P)H dehydrogenase (quinone) activity
I653_02600	COG2814	Major facilitator Superfamily
I653_02605	COG1309	transcriptional regulator
I653_02615	COG0640	Transcriptional regulator
I653_02620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I653_02630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I653_02640	COG0726	polysaccharide deacetylase
I653_02650	COG5002	protein histidine kinase activity
I653_02655	COG0745	RESPONSE REGULATOR receiver
I653_02660	COG0697	spore germination
I653_02665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I653_02670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I653_02675	COG0640	Transcriptional regulator
I653_02680	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I653_02695	COG4585	Histidine kinase
I653_02700	COG2197	response regulator
I653_02705	COG2409	Drug exporters of the RND superfamily
I653_02710	COG0596	Alpha beta hydrolase
I653_02715	COG1811	Na channel or pump
I653_02720	COG0789	Transcriptional regulator
I653_02720	COG4978	Transcriptional regulator
I653_02725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I653_02730	COG0778	Nitroreductase
I653_02735	COG0346	lactoylglutathione lyase activity
I653_02740	COG2259	Doxx family
I653_02745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I653_02765	COG2323	membrane
I653_02770	COG2323	membrane
I653_02775	COG0071	Belongs to the small heat shock protein (HSP20) family
I653_02790	COG1309	transcriptional regulator
I653_02800	COG0456	acetyltransferase
I653_02810	COG2814	Major facilitator Superfamily
I653_02825	COG1113	amino acid transport
I653_02830	COG2318	DinB family
I653_02835	COG1846	Transcriptional regulator
I653_02840	COG1033	growth of symbiont in host cell
I653_02840	COG2409	Drug exporters of the RND superfamily
I653_02845	COG0778	Nitroreductase
I653_02850	COG1846	Transcriptional regulator
I653_02855	COG2814	Major facilitator Superfamily
I653_02860	COG0730	response to heat
I653_02865	COG1802	Transcriptional regulator
I653_02870	COG1388	LysM domain
I653_02870	COG3858	chitin binding
I653_02875	COG1819	glycosyl
I653_02885	COG1785	Belongs to the alkaline phosphatase family
I653_02890	COG5646	InterPro IPR014922
I653_02900	COG0454	-acetyltransferase
I653_02905	COG1078	dGTPase activity
I653_02910	COG1388	LysM domain
I653_02915	COG2814	Major facilitator Superfamily
I653_02920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I653_02925	COG1447	Phosphotransferase system cellobiose-specific component IIA
I653_02930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I653_02935	COG2723	6-phospho-beta-galactosidase activity
I653_02940	COG2188	Transcriptional regulator
I653_02945	COG1940	carbohydrate kinase activity
I653_02950	COG1482	cell wall glycoprotein biosynthetic process
I653_02955	COG4124	Belongs to the glycosyl hydrolase 26 family
I653_02970	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I653_02975	COG0802	atpase or kinase
I653_02980	COG1214	PFAM Peptidase M22, glycoprotease
I653_02985	COG0456	acetyltransferase
I653_02990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I653_02995	COG0488	(ABC) transporter
I653_03000	COG0315	cyclic pyranopterin monophosphate synthase activity
I653_03005	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I653_03010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I653_03015	COG0805	protein transport
I653_03025	COG1266	CAAX protease self-immunity
I653_03030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I653_03035	COG0459	protein refolding
I653_03040	COG1073	alpha beta
I653_03045	COG0457	Tetratricopeptide repeat
I653_03050	COG1063	alcohol dehydrogenase
I653_03055	COG2211	Major facilitator Superfamily
I653_03060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I653_03065	COG1842	Phage shock protein A
I653_03070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I653_03075	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I653_03080	COG4260	virion core protein, lumpy skin disease virus
I653_03090	COG2814	Major facilitator Superfamily
I653_03095	COG1063	alcohol dehydrogenase
I653_03100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I653_03105	COG0823	Involved in the tonB-independent uptake of proteins
I653_03120	COG2267	carboxylic ester hydrolase activity
I653_03130	COG2132	Multicopper oxidase
I653_03135	COG1113	amino acid transport
I653_03140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I653_03145	COG0714	Associated with various cellular activities
I653_03150	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I653_03155	COG1305	Transglutaminase-like
I653_03160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I653_03160	COG0519	Catalyzes the synthesis of GMP from XMP
I653_03175	COG2252	PERMEase
I653_03180	COG3064	Membrane
I653_03190	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I653_03200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I653_03205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I653_03210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I653_03215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I653_03220	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I653_03225	COG0047	phosphoribosylformylglycinamidine synthase activity
I653_03230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I653_03235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I653_03240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I653_03245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I653_03250	COG0138	bifunctional purine biosynthesis protein purh
I653_03255	COG0151	Belongs to the GarS family
I653_03260	COG1522	sequence-specific DNA binding
I653_03265	COG0531	amino acid
I653_03275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I653_03280	COG1470	cell adhesion involved in biofilm formation
I653_03285	COG4496	protein, YerC YecD
I653_03290	COG0069	glutamate synthase activity
I653_03295	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I653_03300	COG0210	DNA helicase
I653_03305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I653_03310	COG4851	CamS sex pheromone cAM373 precursor
I653_03315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I653_03320	COG1285	pathogenesis
I653_03325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I653_03330	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I653_03335	COG0154	amidase activity
I653_03340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I653_03345	COG1309	transcriptional regulator
I653_03350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I653_03355	COG1597	lipid kinase activity
I653_03360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I653_03365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I653_03375	COG5293	efflux transmembrane transporter activity
I653_03425	COG5444	nuclease activity
I653_03435	COG3586	endonuclease activity
I653_03445	COG0457	Tetratricopeptide repeat
I653_03455	COG0217	transcriptional regulatory protein
I653_03465	COG1309	transcriptional regulator
I653_03470	COG3631	Ketosteroid isomerase-related protein
I653_03475	COG0702	epimerase
I653_03490	COG3546	catalase activity
I653_03495	COG0454	-acetyltransferase
I653_03505	COG5578	integral membrane protein
I653_03510	COG2972	Histidine kinase
I653_03515	COG4753	response regulator
I653_03515	COG2207	Transcriptional regulator
I653_03520	COG1653	transport
I653_03525	COG1175	transmembrane transport
I653_03530	COG0395	ABC-type sugar transport system, permease component
I653_03535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I653_03540	COG2207	Transcriptional regulator
I653_03545	COG2755	lipolytic protein G-D-S-L family
I653_03555	COG5578	integral membrane protein
I653_03560	COG3401	FG-GAP repeat protein
I653_03565	COG3401	FG-GAP repeat protein
I653_03570	COG2755	lipolytic protein G-D-S-L family
I653_03575	COG1874	Beta-galactosidase
I653_03585	COG1653	transport
I653_03590	COG4209	transmembrane transport
I653_03595	COG0395	ABC-type sugar transport system, permease component
I653_03600	COG1486	melibiose metabolic process
I653_03605	COG2323	membrane
I653_03610	COG2329	Antibiotic biosynthesis monooxygenase
I653_03615	COG0346	lactoylglutathione lyase activity
I653_03630	COG5583	Uncharacterized small protein (DUF2292)
I653_03635	COG0670	Belongs to the BI1 family
I653_03640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I653_03650	COG2124	cytochrome p450
I653_03650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I653_03655	COG1368	sulfuric ester hydrolase activity
I653_03660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I653_03665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I653_03670	COG1442	glycosyl transferase family 8
I653_03675	COG1216	Glycosyl transferase, family 2
I653_03680	COG1442	glycosyl transferase family 8
I653_03685	COG2223	nitrite transmembrane transporter activity
I653_03690	COG1011	Hydrolase
I653_03695	COG0531	amino acid
I653_03700	COG1012	belongs to the aldehyde dehydrogenase family
I653_03705	COG0840	transmembrane signaling receptor activity
I653_03710	COG0488	(ABC) transporter
I653_03720	COG0789	Transcriptional regulator
I653_03725	COG2814	Major facilitator Superfamily
I653_03740	COG0488	(ABC) transporter
I653_03745	COG0513	Belongs to the DEAD box helicase family
I653_03750	COG0456	acetyltransferase
I653_03755	COG2130	NADP-dependent
I653_03760	COG1120	ATPase activity
I653_03765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_03770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_03775	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I653_03790	COG3866	Pectate lyase
I653_03795	COG0471	metal ion transport
I653_03800	COG3290	protein histidine kinase activity
I653_03805	COG4565	transcriptional regulatory protein
I653_03810	COG3181	Tripartite tricarboxylate transporter family receptor
I653_03820	COG2851	Citrate transporter
I653_03825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I653_03830	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I653_03835	COG1254	Belongs to the acylphosphatase family
I653_03840	COG2258	MOSC domain
I653_03860	COG0024	Methionine aminopeptidase
I653_03865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_03865	COG1263	PTS System
I653_03870	COG1368	sulfuric ester hydrolase activity
I653_03880	COG1115	amino acid carrier protein
I653_03885	COG0531	amino acid
I653_03900	COG0697	spore germination
I653_03905	COG1263	PTS System
I653_03905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_03910	COG0366	Alpha amylase catalytic
I653_03915	COG2188	Transcriptional regulator
I653_03920	COG0778	Nitroreductase
I653_03925	COG0737	Belongs to the 5'-nucleotidase family
I653_03930	COG0693	protein deglycase activity
I653_03935	COG2814	Major facilitator Superfamily
I653_03940	COG4840	Belongs to the UPF0435 family
I653_03945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I653_03950	COG4980	gas vesicle protein
I653_03955	COG1295	ribonuclease BN
I653_03965	COG0477	Major facilitator Superfamily
I653_03975	COG0387	Pfam Sodium calcium exchanger
I653_03985	COG0668	transmembrane transport
I653_03990	COG0535	radical SAM domain protein
I653_04000	COG0726	polysaccharide deacetylase
I653_04005	COG2084	Dehydrogenase
I653_04010	COG0598	Magnesium transport protein CorA
I653_04015	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I653_04020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I653_04030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I653_04035	COG4637	Psort location Cytoplasmic, score
I653_04045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I653_04050	COG0022	dehydrogenase e1 component
I653_04055	COG0508	dehydrogenase complex catalyzes the overall conversion of
I653_04060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I653_04065	COG3284	Transcriptional regulator
I653_04075	COG1742	UPF0060 membrane protein
I653_04095	COG4842	Belongs to the WXG100 family
I653_04100	COG1486	melibiose metabolic process
I653_04105	COG1737	Transcriptional regulator
I653_04110	COG1263	PTS System
I653_04110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_04115	COG1132	(ABC) transporter
I653_04120	COG1132	(ABC) transporter
I653_04125	COG2259	Doxx family
I653_04130	COG2514	catechol 2,3-dioxygenase activity
I653_04135	COG4585	Histidine kinase
I653_04140	COG2197	response regulator
I653_04145	COG1131	(ABC) transporter
I653_04150	COG0842	Transport permease protein
I653_04150	COG1511	domain protein
I653_04155	COG0842	Transport permease protein
I653_04165	COG1695	Transcriptional regulator
I653_04170	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I653_04190	COG1131	(ABC) transporter
I653_04195	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I653_04200	COG1309	transcriptional regulator
I653_04205	COG2814	Major facilitator Superfamily
I653_04210	COG2318	DinB family
I653_04215	COG2814	Major facilitator Superfamily
I653_04220	COG1846	Transcriptional regulator
I653_04225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I653_04225	COG0392	lysyltransferase activity
I653_04230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I653_04235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_04240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_04245	COG0384	phenazine biosynthesis protein PhzF
I653_04250	COG0778	Nitroreductase
I653_04265	COG1090	epimerase
I653_04270	COG2137	regulation of response to DNA damage stimulus
I653_04280	COG2814	Major facilitator Superfamily
I653_04295	COG3103	Sh3 type 3 domain protein
I653_04300	COG5658	integral membrane protein
I653_04305	COG0596	Alpha beta hydrolase
I653_04310	COG0463	Glycosyl transferase, family 2
I653_04315	COG4485	Bacterial membrane protein, YfhO
I653_04320	COG1988	membrane-bound metal-dependent
I653_04325	COG1194	a g-specific adenine glycosylase
I653_04335	COG1028	Short-chain dehydrogenase reductase Sdr
I653_04350	COG3557	Belongs to the UPF0374 family
I653_04355	COG1132	(ABC) transporter
I653_04360	COG4129	membrane
I653_04365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I653_04370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I653_04375	COG0735	belongs to the Fur family
I653_04395	COG4326	sporulation control protein
I653_04405	COG5577	PFAM Coat F domain
I653_04410	COG3340	Belongs to the peptidase S51 family
I653_04415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I653_04420	COG0277	FAD linked oxidase domain protein
I653_04430	COG0753	catalase activity
I653_04435	COG1116	anion transmembrane transporter activity
I653_04440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I653_04445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I653_04450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I653_04465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I653_04475	COG1476	TRANSCRIPTIONal
I653_04480	COG3382	B3 4 domain protein
I653_04485	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I653_04495	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I653_04500	COG0789	Transcriptional regulator
I653_04505	COG1664	Polymer-forming cytoskeletal
I653_04510	COG1664	Polymer-forming cytoskeletal
I653_04520	COG2766	serine protein kinase
I653_04525	COG2718	Belongs to the UPF0229 family
I653_04530	COG1846	Transcriptional regulator
I653_04535	COG1566	PFAM secretion protein HlyD family protein
I653_04540	COG2814	Major facilitator Superfamily
I653_04545	COG0655	NAD(P)H dehydrogenase (quinone) activity
I653_04560	COG1725	Transcriptional regulator
I653_04565	COG1131	(ABC) transporter
I653_04570	COG1131	(ABC) transporter
I653_04575	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I653_04580	COG1278	Cold shock
I653_04585	COG1464	Belongs to the NlpA lipoprotein family
I653_04590	COG3706	GGDEF domain
I653_04595	COG1823	symporter activity
I653_04615	COG5577	PFAM Coat F domain
I653_04620	COG0737	Belongs to the 5'-nucleotidase family
I653_04620	COG1525	nuclease
I653_04620	COG4085	toxin activity
I653_04625	COG3764	Sortase (surface protein transpeptidase)
I653_04630	COG0564	pseudouridine synthase activity
I653_04640	COG0517	IMP dehydrogenase activity
I653_04645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I653_04650	COG3153	acetyltransferase
I653_04650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I653_04655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I653_04660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I653_04665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I653_04670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I653_04675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I653_04680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I653_04685	COG2203	Gaf domain
I653_04685	COG4585	Histidine kinase
I653_04690	COG2197	response regulator
I653_04695	COG0431	NADPH-dependent FMN reductase
I653_04710	COG0791	NLP P60 protein
I653_04710	COG1388	LysM domain
I653_04715	COG1959	2 iron, 2 sulfur cluster binding
I653_04730	COG0668	transmembrane transport
I653_04735	COG2719	SpoVR family
I653_04740	COG1785	Belongs to the alkaline phosphatase family
I653_04745	COG0791	NLP P60 protein
I653_04745	COG1388	LysM domain
I653_04750	COG0583	DNA-binding transcription factor activity
I653_04755	COG0372	Belongs to the citrate synthase family
I653_04760	COG1028	Short-chain dehydrogenase reductase Sdr
I653_04765	COG0531	amino acid
I653_04770	COG0733	neurotransmitter:sodium symporter activity
I653_04775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I653_04780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I653_04785	COG0456	acetyltransferase
I653_04800	COG1595	DNA-templated transcription, initiation
I653_04805	COG0667	Aldo Keto reductase
I653_04810	COG0204	Acyl-transferase
I653_04815	COG1253	flavin adenine dinucleotide binding
I653_04820	COG0789	Transcriptional regulator
I653_04825	COG0436	Aminotransferase
I653_04830	COG1253	flavin adenine dinucleotide binding
I653_04835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I653_04840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I653_04845	COG0584	glycerophosphoryl diester phosphodiesterase
I653_04855	COG0668	transmembrane transport
I653_04860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I653_04865	COG0726	polysaccharide deacetylase
I653_04870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I653_04875	COG1757	Na H antiporter
I653_04880	COG0589	response to stress
I653_04890	COG1132	(ABC) transporter
I653_04895	COG1132	(ABC) transporter
I653_04900	COG0702	epimerase
I653_04915	COG0189	ligase activity
I653_04920	COG0189	ligase activity
I653_04925	COG4399	Belongs to the UPF0754 family
I653_04930	COG3679	Belongs to the UPF0342 family
I653_04935	COG4335	DNA alkylation repair
I653_04940	COG0561	phosphatase activity
I653_04945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I653_04950	COG0475	glutathione-regulated potassium exporter activity
I653_04955	COG0490	domain, Protein
I653_04965	COG1024	Enoyl-CoA hydratase
I653_04975	COG4152	abc transporter atp-binding protein
I653_04980	COG1668	transmembrane transport
I653_04985	COG0420	3'-5' exonuclease activity
I653_04990	COG4717	serine-type aminopeptidase activity
I653_04995	COG3481	metal-dependent phosphohydrolase, HD sub domain
I653_05010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I653_05035	COG1846	Transcriptional regulator
I653_05040	COG4980	gas vesicle protein
I653_05055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I653_05060	COG0537	adenosine 5'-monophosphoramidase activity
I653_05065	COG1131	(ABC) transporter
I653_05070	COG4473	ABC transporter
I653_05080	COG1473	amidohydrolase
I653_05085	COG3069	C4-dicarboxylate transmembrane transporter activity
I653_05095	COG2329	Antibiotic biosynthesis monooxygenase
I653_05100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I653_05105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I653_05120	COG1309	transcriptional regulator
I653_05125	COG1511	domain protein
I653_05130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I653_05135	COG4377	Putative membrane peptidase family (DUF2324)
I653_05145	COG1363	Peptidase, m42
I653_05150	COG4405	Protein conserved in bacteria
I653_05155	COG1301	dicarboxylic acid transport
I653_05165	COG1234	tRNA 3'-trailer cleavage
I653_05170	COG0095	Lipoate-protein ligase
I653_05175	COG0702	epimerase
I653_05200	COG0501	Belongs to the peptidase M48B family
I653_05205	COG1404	Belongs to the peptidase S8 family
I653_05210	COG0456	acetyltransferase
I653_05215	COG0456	acetyltransferase
I653_05220	COG0604	alcohol dehydrogenase
I653_05225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I653_05230	COG0406	alpha-ribazole phosphatase activity
I653_05235	COG0183	Belongs to the thiolase family
I653_05240	COG0318	PFAM AMP-dependent synthetase and ligase
I653_05245	COG1268	BioY protein
I653_05250	COG0840	transmembrane signaling receptor activity
I653_05255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I653_05255	COG0723	plastoquinol--plastocyanin reductase activity
I653_05260	COG1028	Short-chain dehydrogenase reductase Sdr
I653_05270	COG4903	ComK protein
I653_05275	COG1028	Short-chain dehydrogenase reductase Sdr
I653_05285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I653_05300	COG0398	Pfam SNARE associated Golgi protein
I653_05305	COG0681	Belongs to the peptidase S26 family
I653_05310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I653_05315	COG1846	Transcriptional regulator
I653_05320	COG0738	Major facilitator superfamily
I653_05325	COG0673	inositol 2-dehydrogenase activity
I653_05330	COG0561	phosphatase activity
I653_05335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I653_05340	COG1609	Transcriptional regulator
I653_05345	COG3180	Ammonia monooxygenase
I653_05350	COG0477	Major facilitator Superfamily
I653_05350	COG2814	Major facilitator Superfamily
I653_05355	COG4533	DNA binding
I653_05365	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I653_05370	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I653_05375	COG1074	ATP-dependent DNA helicase activity
I653_05380	COG0420	3'-5' exonuclease activity
I653_05385	COG0419	ATPase involved in DNA repair
I653_05390	COG1403	HNH endonuclease
I653_05435	COG5337	Spore coat protein CotH
I653_05440	COG0179	Fumarylacetoacetate (FAA) hydrolase
I653_05450	COG1404	Belongs to the peptidase S8 family
I653_05460	COG0367	asparagine synthase
I653_05465	COG1562	ergosterol biosynthetic process
I653_05470	COG0534	Mate efflux family protein
I653_05475	COG2207	Transcriptional regulator
I653_05475	COG1917	Cupin 2, conserved barrel domain protein
I653_05480	COG1609	Transcriptional regulator
I653_05490	COG0673	inositol 2-dehydrogenase activity
I653_05495	COG2318	DinB family
I653_05500	COG1279	arginine transmembrane transporter activity
I653_05505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I653_05510	COG1357	PFAM Pentapeptide repeats (8 copies)
I653_05515	COG2267	carboxylic ester hydrolase activity
I653_05520	COG0529	Catalyzes the synthesis of activated sulfate
I653_05525	COG2046	Belongs to the sulfate adenylyltransferase family
I653_05530	COG0175	sulfate reduction
I653_05535	COG2045	Belongs to the ComB family
I653_05540	COG1809	phosphosulfolactate synthase activity
I653_05545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I653_05550	COG4948	Mandelate Racemase Muconate Lactonizing
I653_05555	COG2814	Major facilitator Superfamily
I653_05560	COG0454	-acetyltransferase
I653_05565	COG2153	protein acetylation
I653_05570	COG0646	methionine synthase
I653_05570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I653_05580	COG1666	GTP binding
I653_05585	COG2996	Protein conserved in bacteria
I653_05605	COG1695	Transcriptional regulator
I653_05620	COG3227	Zinc metalloprotease (Elastase)
I653_05625	COG1307	EDD domain protein, DegV family
I653_05630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I653_05650	COG0561	phosphatase activity
I653_05655	COG1073	alpha beta
I653_05660	COG2151	metal-sulfur cluster biosynthetic enzyme
I653_05670	COG0277	FAD linked oxidase domain protein
I653_05675	COG2271	Major facilitator Superfamily
I653_05680	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I653_05695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I653_05700	COG0505	Belongs to the CarA family
I653_05705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I653_05710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I653_05725	COG2267	carboxylic ester hydrolase activity
I653_05735	COG1744	ABC transporter substrate-binding protein PnrA-like
I653_05750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I653_05755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I653_05760	COG5504	Zn-dependent protease
I653_05765	COG0444	Belongs to the ABC transporter superfamily
I653_05770	COG4608	Belongs to the ABC transporter superfamily
I653_05790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I653_05800	COG0180	Tryptophanyl-tRNA synthetase
I653_05805	COG4166	transmembrane transport
I653_05810	COG0601	transmembrane transport
I653_05815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I653_05820	COG0444	Belongs to the ABC transporter superfamily
I653_05825	COG4608	Belongs to the ABC transporter superfamily
I653_05830	COG2814	Major facilitator Superfamily
I653_05835	COG0456	acetyltransferase
I653_05840	COG1393	Belongs to the ArsC family
I653_05845	COG0861	Integral membrane protein TerC family
I653_05850	COG4862	establishment of competence for transformation
I653_05855	COG4469	Competence protein
I653_05860	COG1164	Oligoendopeptidase f
I653_05875	COG2346	COG2346, Truncated hemoglobins
I653_05880	COG0741	lytic transglycosylase activity
I653_05885	COG4116	CYTH
I653_05895	COG2357	RelA SpoT domain protein
I653_05900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I653_05905	COG0564	pseudouridine synthase activity
I653_05910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I653_05915	COG0569	domain protein
I653_05915	COG0475	glutathione-regulated potassium exporter activity
I653_05920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I653_05925	COG0352	thiamine-phosphate diphosphorylase activity
I653_05930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I653_05935	COG2104	thiamine diphosphate biosynthetic process
I653_05940	COG2022	thiamine diphosphate biosynthetic process
I653_05945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I653_05950	COG0351	phosphomethylpyrimidine kinase
I653_05955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I653_06010	COG0210	DNA helicase
I653_06020	COG2153	protein acetylation
I653_06025	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I653_06030	COG2382	esterase
I653_06035	COG0626	cystathionine gamma-synthase activity
I653_06040	COG0626	cystathionine gamma-synthase activity
I653_06045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I653_06050	COG5505	Protein of unknown function (DUF819)
I653_06075	COG3409	Peptidoglycan-binding domain 1 protein
I653_06075	COG5632	N-Acetylmuramoyl-L-alanine amidase
I653_06105	COG0457	Tetratricopeptide repeat
I653_06110	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I653_06120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I653_06120	COG3711	transcriptional antiterminator
I653_06125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I653_06125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I653_06125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I653_06130	COG1482	cell wall glycoprotein biosynthetic process
I653_06140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I653_06145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I653_06160	COG0109	protoheme IX farnesyltransferase activity
I653_06170	COG0726	polysaccharide deacetylase
I653_06185	COG5504	Zn-dependent protease
I653_06190	COG2205	protein histidine kinase activity
I653_06200	COG3383	formate dehydrogenase (NAD+) activity
I653_06205	COG2427	Protein of unknown function (DUF1641)
I653_06215	COG1051	belongs to the nudix hydrolase family
I653_06225	COG2124	cytochrome p450
I653_06230	COG1819	glycosyl
I653_06240	COG1587	Uroporphyrinogen-III synthase
I653_06245	COG0390	transport system, permease component
I653_06250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I653_06255	COG0697	spore germination
I653_06260	COG4297	protein containing double-stranded beta helix domain
I653_06270	COG1252	NADH dehydrogenase
I653_06275	COG1904	glucuronate isomerase
I653_06280	COG2211	Major facilitator Superfamily
I653_06285	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I653_06290	COG1063	alcohol dehydrogenase
I653_06295	COG1312	Catalyzes the dehydration of D-mannonate
I653_06300	COG1028	Short-chain dehydrogenase reductase Sdr
I653_06305	COG2271	Major facilitator Superfamily
I653_06310	COG1609	Transcriptional regulator
I653_06315	COG0246	Mannitol dehydrogenase
I653_06320	COG2721	sulfolactate sulfo-lyase activity
I653_06325	COG0730	response to heat
I653_06330	COG2318	DinB family
I653_06335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I653_06340	COG0457	Tetratricopeptide repeat
I653_06350	COG2350	Protein conserved in bacteria
I653_06355	COG1388	LysM domain
I653_06355	COG5632	N-Acetylmuramoyl-L-alanine amidase
I653_06355	COG3409	Peptidoglycan-binding domain 1 protein
I653_06365	COG4195	phage-related replication protein
I653_06370	COG3546	catalase activity
I653_06375	COG2856	Zn peptidase
I653_06380	COG1396	sequence-specific DNA binding
I653_06390	COG1522	sequence-specific DNA binding
I653_06395	COG1484	DNA-dependent DNA replication
I653_06420	COG1595	DNA-templated transcription, initiation
I653_06425	COG3728	DNA packaging
I653_06425	COG5484	DNA packaging
I653_06430	COG1783	phage Terminase large subunit
I653_06435	COG5518	Phage portal protein
I653_06440	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I653_06445	COG4653	Phage capsid family
I653_06495	COG3953	SLT domain
I653_06495	COG5412	phage tail tape measure protein
I653_06500	COG1652	LysM domain
I653_06505	COG4193	domain, Protein
I653_06515	COG3628	GPW Gp25 family protein
I653_06520	COG3299	homolog of phage Mu protein gp47
I653_06525	COG3778	Protein conserved in bacteria
I653_06560	COG3409	Peptidoglycan-binding domain 1 protein
I653_06560	COG5632	N-Acetylmuramoyl-L-alanine amidase
I653_06575	COG0306	phosphate transporter
I653_06580	COG1392	Phosphate transport regulator
I653_06585	COG0531	amino acid
I653_06590	COG0346	lactoylglutathione lyase activity
I653_06595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I653_06600	COG0463	Glycosyl transferase, family 2
I653_06610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I653_06615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I653_06620	COG2362	D-Aminopeptidase
I653_06625	COG0601	transmembrane transport
I653_06630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I653_06635	COG0444	Belongs to the ABC transporter superfamily
I653_06640	COG4166	transmembrane transport
I653_06645	COG1619	proteins homologs of microcin C7 resistance protein MccF
I653_06650	COG4948	Mandelate Racemase Muconate Lactonizing
I653_06655	COG0791	NLP P60 protein
I653_06660	COG4608	Belongs to the ABC transporter superfamily
I653_06665	COG2706	6-phosphogluconolactonase activity
I653_06670	COG1834	amidinotransferase
I653_06675	COG1607	acyl-coa hydrolase
I653_06680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I653_06680	COG1017	nitric oxide dioxygenase activity
I653_06690	COG2323	membrane
I653_06695	COG2318	DinB family
I653_06700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I653_06705	COG2076	Multidrug Resistance protein
I653_06710	COG2076	Multidrug Resistance protein
I653_06715	COG0788	formyltetrahydrofolate deformylase activity
I653_06720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I653_06725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I653_06730	COG1764	response to oxidative stress
I653_06735	COG1846	Transcriptional regulator
I653_06740	COG1764	response to oxidative stress
I653_06745	COG0590	tRNA wobble adenosine to inosine editing
I653_06755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I653_06760	COG1404	Belongs to the peptidase S8 family
I653_06765	COG1366	Belongs to the anti-sigma-factor antagonist family
I653_06770	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I653_06775	COG1122	ATPase activity
I653_06780	COG4721	ABC-type cobalt transport system, permease component
I653_06790	COG0745	RESPONSE REGULATOR receiver
I653_06795	COG3850	Histidine kinase
I653_06795	COG5002	protein histidine kinase activity
I653_06800	COG3212	peptidase
I653_06805	COG3212	peptidase
I653_06820	COG2239	Acts as a magnesium transporter
I653_06825	COG0789	Transcriptional regulator
I653_06840	COG1846	Transcriptional regulator
I653_06845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I653_06850	COG0726	polysaccharide deacetylase
I653_06855	COG1408	metallophosphoesterase
I653_06865	COG0463	Glycosyl transferase, family 2
I653_06870	COG1793	dna ligase
I653_06870	COG3285	dna ligase
I653_06875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I653_06880	COG5001	Diguanylate cyclase
I653_06880	COG3300	MHYT domain
I653_06885	COG0586	Pfam SNARE associated Golgi protein
I653_06890	COG0861	Integral membrane protein TerC family
I653_06895	COG1191	sigma factor activity
I653_06915	COG0501	Belongs to the peptidase M48B family
I653_06920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I653_06935	COG3594	Acyltransferase
I653_06940	COG5002	protein histidine kinase activity
I653_06945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I653_06955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I653_06960	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I653_06965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I653_06970	COG0436	Aminotransferase
I653_06975	COG1850	ribulose-bisphosphate carboxylase activity
I653_06980	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
I653_06985	COG0235	Class ii aldolase
I653_06990	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I653_06995	COG3339	Conserved Protein
I653_07010	COG3852	Histidine kinase
I653_07015	COG1846	Transcriptional regulator
I653_07020	COG1360	Flagellar Motor Protein
I653_07025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I653_07035	COG0542	response to heat
I653_07040	COG3949	Membrane
I653_07045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I653_07050	COG0720	synthase
I653_07055	COG0602	queuosine metabolic process
I653_07060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I653_07065	COG1388	LysM domain
I653_07065	COG4641	Protein conserved in bacteria
I653_07070	COG1388	LysM domain
I653_07075	COG3858	chitin binding
I653_07085	COG4873	Protein conserved in bacteria
I653_07095	COG3773	Cell wall hydrolase
I653_07100	COG2244	polysaccharide biosynthetic process
I653_07105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I653_07110	COG2217	Heavy metal translocating P-type atpase
I653_07120	COG0006	proline dipeptidase activity
I653_07130	COG1609	Transcriptional regulator
I653_07135	COG3711	transcriptional antiterminator
I653_07140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_07140	COG1263	PTS System
I653_07140	COG2190	(PTS) system
I653_07145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I653_07150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I653_07160	COG1533	DNA photolyase activity
I653_07165	COG0456	acetyltransferase
I653_07170	COG0840	transmembrane signaling receptor activity
I653_07175	COG2084	Dehydrogenase
I653_07180	COG2340	Cysteine-rich secretory protein family
I653_07185	COG0768	penicillin binding
I653_07190	COG4191	Histidine kinase
I653_07195	COG0436	Aminotransferase
I653_07205	COG0835	chemotaxis
I653_07205	COG0784	Response regulator, receiver
I653_07215	COG2814	Major facilitator Superfamily
I653_07220	COG1376	ErfK ybiS ycfS ynhG family protein
I653_07225	COG1408	metallophosphoesterase
I653_07230	COG1028	Short-chain dehydrogenase reductase Sdr
I653_07235	COG2200	EAL domain
I653_07240	COG4703	Protein of unknown function (DUF1797)
I653_07245	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I653_07255	COG0517	IMP dehydrogenase activity
I653_07260	COG0583	DNA-binding transcription factor activity
I653_07265	COG0716	FMN binding
I653_07275	COG0716	FMN binding
I653_07280	COG2171	N-acyltransferase activity
I653_07285	COG1473	amidohydrolase
I653_07295	COG0668	transmembrane transport
I653_07300	COG0450	alkyl hydroperoxide reductase
I653_07305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I653_07320	COG0746	molybdenum cofactor guanylyltransferase activity
I653_07325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I653_07330	COG0303	'Molybdopterin
I653_07335	COG1763	Mo-molybdopterin cofactor biosynthetic process
I653_07340	COG0314	molybdopterin synthase activity
I653_07345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I653_07350	COG1132	(ABC) transporter
I653_07355	COG1132	(ABC) transporter
I653_07365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I653_07370	COG1136	(ABC) transporter
I653_07375	COG0577	efflux transmembrane transporter activity
I653_07380	COG1349	DNA-binding transcription factor activity
I653_07385	COG1105	Belongs to the carbohydrate kinase PfkB family
I653_07390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I653_07390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I653_07390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I653_07395	COG0681	Belongs to the peptidase S26 family
I653_07405	COG0488	(ABC) transporter
I653_07410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I653_07415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I653_07420	COG2309	aminopeptidase activity
I653_07430	COG1077	Cell shape determining protein MreB Mrl
I653_07435	COG2002	toxin-antitoxin pair type II binding
I653_07440	COG3852	Histidine kinase
I653_07445	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I653_07445	COG2105	PFAM AIG2 family protein
I653_07450	COG0569	domain protein
I653_07455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I653_07460	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I653_07470	COG0561	phosphatase activity
I653_07475	COG0242	peptide deformylase activity
I653_07485	COG0497	DNA recombination
I653_07490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I653_07495	COG0022	dehydrogenase e1 component
I653_07500	COG0508	dehydrogenase complex catalyzes the overall conversion of
I653_07505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I653_07510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I653_07520	COG1982	Orn Lys Arg decarboxylase major
I653_07525	COG4476	Belongs to the UPF0223 family
I653_07530	COG4493	Belongs to the UPF0637 family
I653_07540	COG0483	inositol monophosphate 1-phosphatase activity
I653_07550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I653_07570	COG1595	DNA-templated transcription, initiation
I653_07600	COG4896	Protein conserved in bacteria
I653_07610	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I653_07615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I653_07620	COG2066	Belongs to the glutaminase family
I653_07625	COG4838	Belongs to the UPF0358 family
I653_07630	COG0772	Belongs to the SEDS family
I653_07635	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I653_07640	COG1612	heme a metabolic process
I653_07645	COG0109	protoheme IX farnesyltransferase activity
I653_07650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I653_07650	COG2010	Cytochrome c
I653_07655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I653_07660	COG1845	cytochrome c oxidase, subunit III
I653_07665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I653_07670	COG3336	cytochrome c oxidase
I653_07680	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I653_07685	COG2340	Cysteine-rich secretory protein family
I653_07700	COG3679	Belongs to the UPF0342 family
I653_07705	COG4471	UPF0298 protein
I653_07710	COG0742	ribosomal rna small subunit methyltransferase
I653_07715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I653_07720	COG3314	Sporulation integral membrane protein YlbJ
I653_07725	COG1752	Esterase of the alpha-beta hydrolase superfamily
I653_07730	COG3480	Lon protease (S16) C-terminal proteolytic domain
I653_07750	COG1399	metal-binding, possibly nucleic acid-binding protein
I653_07755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I653_07765	COG0454	-acetyltransferase
I653_07770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I653_07775	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I653_07780	COG2001	Belongs to the MraZ family
I653_07785	COG0275	rRNA processing
I653_07790	COG4839	cell division protein FtsL
I653_07800	COG0768	penicillin binding
I653_07810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I653_07820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I653_07825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I653_07830	COG0772	Belongs to the SEDS family
I653_07835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I653_07840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I653_07845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I653_07850	COG3879	Bacterial protein of unknown function (DUF881)
I653_07855	COG3879	Bacterial protein of unknown function (DUF881)
I653_07860	COG3856	small basic protein
I653_07865	COG0849	cell division
I653_07870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I653_07875	COG1404	Belongs to the peptidase S8 family
I653_07875	COG4412	M6 family metalloprotease domain protein
I653_07885	COG1191	sigma factor activity
I653_07890	COG1191	sigma factor activity
I653_07895	COG1119	ATPase activity
I653_07900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I653_07905	COG1873	PFAM PRC-barrel domain
I653_07915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I653_07920	COG1799	cell septum assembly
I653_07925	COG0762	integral membrane protein
I653_07930	COG2302	S4 RNA-binding domain
I653_07935	COG3599	regulation of cell shape
I653_07940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I653_07945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I653_07950	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I653_07955	COG0564	pseudouridine synthase activity
I653_07960	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I653_07965	COG2233	PERMEase
I653_07970	COG0540	Belongs to the ATCase OTCase family
I653_07975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I653_07980	COG0505	Belongs to the CarA family
I653_07985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I653_07990	COG0543	2 iron, 2 sulfur cluster binding
I653_07995	COG0167	dihydroorotate dehydrogenase activity
I653_08000	COG0284	orotidine-5'-phosphate decarboxylase activity
I653_08005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I653_08010	COG0175	sulfate reduction
I653_08015	COG0306	phosphate transporter
I653_08020	COG2046	Belongs to the sulfate adenylyltransferase family
I653_08025	COG0529	Catalyzes the synthesis of activated sulfate
I653_08030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I653_08035	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I653_08040	COG1648	precorrin-2 dehydrogenase activity
I653_08050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I653_08055	COG1561	YicC-like family, N-terminal region
I653_08060	COG2052	Domain of unknown function (DUF370)
I653_08065	COG0194	GDP metabolic process
I653_08070	COG1758	RNA polymerase activity
I653_08075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I653_08080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I653_08085	COG0242	peptide deformylase activity
I653_08090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I653_08095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I653_08095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I653_08100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I653_08105	COG0631	protein serine/threonine phosphatase activity
I653_08110	COG2815	serine threonine protein kinase
I653_08110	COG0515	serine threonine protein kinase
I653_08115	COG1162	GTPase activity
I653_08120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I653_08125	COG1564	THIamine pyrophosphokinase
I653_08135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I653_08140	COG1302	Protein conserved in bacteria
I653_08145	COG1461	Dihydroxyacetone kinase
I653_08150	COG1760	l-serine dehydratase
I653_08155	COG1760	l-serine dehydratase
I653_08160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I653_08165	COG2050	protein possibly involved in aromatic compounds catabolism
I653_08165	COG1349	DNA-binding transcription factor activity
I653_08170	COG0416	fatty acid biosynthetic process
I653_08175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I653_08180	COG1028	Short-chain dehydrogenase reductase Sdr
I653_08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I653_08190	COG0571	ribonuclease III activity
I653_08195	COG1196	nuclear chromosome segregation
I653_08200	COG0552	protein localization to endoplasmic reticulum
I653_08210	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I653_08215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I653_08220	COG0228	four-way junction DNA binding
I653_08225	COG1837	Belongs to the UPF0109 family
I653_08235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I653_08240	COG0336	Belongs to the RNA methyltransferase TrmD family
I653_08245	COG0335	large ribosomal subunit rRNA binding
I653_08250	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I653_08255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I653_08265	COG2257	FlhB HrpN YscU SpaS Family
I653_08270	COG0045	succinate-CoA ligase (ADP-forming) activity
I653_08275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I653_08280	COG0758	DNA mediated transformation
I653_08285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I653_08290	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I653_08295	COG4974	Belongs to the 'phage' integrase family
I653_08300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I653_08305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I653_08310	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I653_08315	COG1815	bacterial-type flagellum-dependent cell motility
I653_08320	COG1558	bacterial-type flagellum-dependent cell motility
I653_08325	COG1677	Flagellar hook-basal body complex protein FliE
I653_08330	COG1766	The M ring may be actively involved in energy transduction
I653_08335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I653_08340	COG1317	bacterial-type flagellum organization
I653_08345	COG1157	protein secretion by the type III secretion system
I653_08350	COG2882	bacterial-type flagellum organization
I653_08355	COG3334	PFAM MgtE intracellular
I653_08360	COG3144	bacterial-type flagellum assembly
I653_08365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I653_08370	COG4786	Flagellar basal body rod
I653_08375	COG1582	Flagellar protein (FlbD)
I653_08380	COG1580	Controls the rotational direction of flagella during chemotaxis
I653_08385	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I653_08390	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I653_08390	COG1776	CheC inhibitor of MCP methylation
I653_08395	COG2201	protein-glutamate methylesterase activity
I653_08400	COG3190	flagellar
I653_08405	COG1338	Plays a role in the flagellum-specific transport system
I653_08410	COG1987	bacterial-type flagellum assembly
I653_08415	COG1684	flagellar biosynthetic protein fliR
I653_08420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I653_08425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I653_08430	COG1419	protein localization to endoplasmic reticulum
I653_08435	COG0455	bacterial-type flagellum organization
I653_08440	COG2201	protein-glutamate methylesterase activity
I653_08445	COG0643	Histidine kinase
I653_08445	COG2198	Histidine kinase
I653_08450	COG0835	chemotaxis
I653_08455	COG1776	CheC inhibitor of MCP methylation
I653_08460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I653_08465	COG1191	sigma factor activity
I653_08475	COG0052	Belongs to the universal ribosomal protein uS2 family
I653_08480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I653_08485	COG0528	UMP kinase activity
I653_08490	COG0233	cytoplasmic translational termination
I653_08495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I653_08500	COG4589	Belongs to the CDS family
I653_08505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I653_08510	COG0750	zinc metalloprotease
I653_08515	COG0442	prolyl-tRNA aminoacylation
I653_08520	COG2176	DNA-directed DNA polymerase activity
I653_08525	COG0779	Required for maturation of 30S ribosomal subunits
I653_08530	COG0195	Participates in both transcription termination and antitermination
I653_08535	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I653_08540	COG1358	cellular component organization or biogenesis
I653_08545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I653_08550	COG1550	Protein conserved in bacteria
I653_08555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I653_08560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I653_08565	COG0196	riboflavin kinase activity
I653_08570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I653_08575	COG1185	polyribonucleotide nucleotidyltransferase activity
I653_08580	COG0726	polysaccharide deacetylase
I653_08585	COG0612	Peptidase, M16
I653_08590	COG1873	PFAM PRC-barrel domain
I653_08595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I653_08600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I653_08605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I653_08610	COG0527	aspartate kinase activity
I653_08615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I653_08620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I653_08625	COG0740	serine-type endopeptidase activity
I653_08635	COG1674	ftsk spoiiie
I653_08635	COG4980	gas vesicle protein
I653_08640	COG2188	Transcriptional regulator
I653_08645	COG2814	Major facilitator Superfamily
I653_08650	COG0612	Peptidase, M16
I653_08655	COG0612	Peptidase, M16
I653_08660	COG0300	oxidoreductase activity
I653_08675	COG1426	Protein conserved in bacteria
I653_08680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I653_08685	COG1546	Belongs to the CinA family
I653_08685	COG1058	Belongs to the CinA family
I653_08690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I653_08695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I653_08700	COG1418	mRNA catabolic process
I653_08705	COG1692	metallophosphoesterase
I653_08710	COG2359	stage V sporulation protein S
I653_08715	COG1063	alcohol dehydrogenase
I653_08720	COG0156	8-amino-7-oxononanoate synthase activity
I653_08725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I653_08730	COG4550	Control of competence regulator ComK, YlbF/YmcA
I653_08740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I653_08745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I653_08760	COG3226	Transcriptional regulator
I653_08765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I653_08775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I653_08780	COG3321	synthase
I653_08785	COG2070	2-Nitropropane dioxygenase
I653_08785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I653_08790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I653_08795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I653_08800	COG3425	synthase
I653_08805	COG1024	Enoyl-CoA hydratase
I653_08810	COG1024	Enoyl-CoA hydratase
I653_08815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_08815	COG0318	PFAM AMP-dependent synthetase and ligase
I653_08815	COG0300	oxidoreductase activity
I653_08815	COG1028	Short-chain dehydrogenase reductase Sdr
I653_08815	COG3321	synthase
I653_08830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I653_08830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_08830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I653_08830	COG1028	Short-chain dehydrogenase reductase Sdr
I653_08830	COG3321	synthase
I653_08835	COG4221	oxidoreductase activity
I653_08835	COG1028	Short-chain dehydrogenase reductase Sdr
I653_08835	COG3321	synthase
I653_08835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_08840	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I653_08840	COG3321	synthase
I653_08840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I653_08840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I653_08845	COG2124	cytochrome p450
I653_08855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I653_08860	COG1404	Belongs to the peptidase S8 family
I653_08870	COG4195	phage-related replication protein
I653_08875	COG1764	response to oxidative stress
I653_08880	COG2076	Multidrug Resistance protein
I653_08885	COG2076	Multidrug Resistance protein
I653_08900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I653_08905	COG1923	regulation of RNA biosynthetic process
I653_08920	COG1780	Probably involved in ribonucleotide reductase function
I653_08925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I653_08930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I653_08935	COG4112	unkown
I653_08940	COG0860	N-Acetylmuramoyl-L-alanine amidase
I653_08945	COG0464	growth
I653_08955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I653_08960	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I653_08965	COG0789	Transcriptional regulator
I653_08970	COG0174	glutamine synthetase
I653_08995	COG5444	nuclease activity
I653_09030	COG4282	regulation of fungal-type cell wall biogenesis
I653_09040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I653_09055	COG3655	Transcriptional regulator
I653_09085	COG2211	Major facilitator Superfamily
I653_09090	COG3507	Belongs to the glycosyl hydrolase 43 family
I653_09095	COG1940	carbohydrate kinase activity
I653_09100	COG2115	Belongs to the xylose isomerase family
I653_09105	COG1070	Carbohydrate kinase
I653_09115	COG1525	nuclease
I653_09120	COG2814	Major facilitator Superfamily
I653_09125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I653_09135	COG0756	dUTP diphosphatase activity
I653_09145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I653_09180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I653_09190	COG3832	glyoxalase III activity
I653_09205	COG0697	spore germination
I653_09210	COG0531	amino acid
I653_09240	COG4195	phage-related replication protein
I653_09250	COG0346	lactoylglutathione lyase activity
I653_09255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I653_09260	COG1388	LysM domain
I653_09265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I653_09270	COG4224	UPF0291 protein
I653_09275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I653_09285	COG3763	UPF0154 protein
I653_09295	COG0785	Cytochrome C biogenesis protein
I653_09300	COG2201	protein-glutamate methylesterase activity
I653_09305	COG4846	Membrane protein involved in cytochrome C biogenesis
I653_09315	COG0071	Belongs to the small heat shock protein (HSP20) family
I653_09330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I653_09335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I653_09355	COG0824	Thioesterase
I653_09365	COG4841	protein insertion into membrane
I653_09370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I653_09380	COG1832	CoA-binding protein
I653_09385	COG0187	DNA topoisomerase II activity
I653_09390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I653_09405	COG1115	amino acid carrier protein
I653_09410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I653_09425	COG5520	Belongs to the glycosyl hydrolase 30 family
I653_09430	COG3507	Belongs to the glycosyl hydrolase 43 family
I653_09440	COG2246	polysaccharide biosynthetic process
I653_09445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I653_09450	COG0586	Pfam SNARE associated Golgi protein
I653_09455	COG2404	hydrolase activity, acting on ester bonds
I653_09460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I653_09465	COG1024	Enoyl-CoA hydratase
I653_09470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I653_09475	COG0511	ligase activity, forming carbon-carbon bonds
I653_09480	COG0439	Biotin carboxylase
I653_09485	COG0318	PFAM AMP-dependent synthetase and ligase
I653_09490	COG1960	acyl-CoA dehydrogenase activity
I653_09500	COG1649	PFAM Uncharacterised BCR, COG1649
I653_09510	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I653_09510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_09515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_09535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_09540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_09545	COG2027	D-alanyl-D-alanine carboxypeptidase
I653_09550	COG2017	converts alpha-aldose to the beta-anomer
I653_09555	COG0534	Mate efflux family protein
I653_09565	COG0582	viral genome integration into host DNA
I653_09570	COG0166	Belongs to the GPI family
I653_09575	COG0405	Gamma-glutamyltransferase
I653_09580	COG0583	DNA-binding transcription factor activity
I653_09585	COG0604	alcohol dehydrogenase
I653_09590	COG0493	'glutamate synthase
I653_09595	COG0069	glutamate synthase activity
I653_09595	COG0067	glutamate synthase
I653_09595	COG0070	glutamate synthase
I653_09600	COG0583	DNA-binding transcription factor activity
I653_09605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I653_09610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I653_09620	COG0300	oxidoreductase activity
I653_09625	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I653_09635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I653_09640	COG2814	Major facilitator Superfamily
I653_09645	COG1070	Carbohydrate kinase
I653_09650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I653_09660	COG0243	molybdopterin cofactor binding
I653_09685	COG5278	phosphoserine phosphatase activity
I653_09685	COG0840	transmembrane signaling receptor activity
I653_09690	COG2368	4-hydroxyphenylacetate
I653_09695	COG4305	rare lipoprotein A
I653_09700	COG3619	membrane
I653_09705	COG3866	Pectate lyase
I653_09710	COG2135	peptidase activity
I653_09720	COG2140	Oxalate decarboxylase
I653_09740	COG2720	vancomycin resistance protein
I653_09750	COG3655	Transcriptional regulator
I653_09755	COG3739	integral membrane protein
I653_09760	COG0583	DNA-binding transcription factor activity
I653_09765	COG0697	spore germination
I653_09775	COG0693	protein deglycase activity
I653_09780	COG2367	Beta-lactamase
I653_09800	COG3848	Pyruvate phosphate dikinase
I653_09800	COG0574	Belongs to the PEP-utilizing enzyme family
I653_09805	COG0726	polysaccharide deacetylase
I653_09810	COG1793	dna ligase
I653_09835	COG5444	nuclease activity
I653_09840	COG4282	regulation of fungal-type cell wall biogenesis
I653_09845	COG1231	oxidoreductase activity
I653_09850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I653_09855	COG2207	Transcriptional regulator
I653_09855	COG0662	Cupin 2, conserved barrel domain protein
I653_09860	COG0456	acetyltransferase
I653_09865	COG1309	transcriptional regulator
I653_09870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I653_09875	COG3708	Transcriptional regulator
I653_09880	COG2378	regulation of single-species biofilm formation
I653_09890	COG0640	Transcriptional regulator
I653_09895	COG0741	lytic transglycosylase activity
I653_09900	COG2322	membrane
I653_09915	COG1619	proteins homologs of microcin C7 resistance protein MccF
I653_09920	COG3239	Fatty acid desaturase
I653_09925	COG4585	Histidine kinase
I653_09930	COG2197	response regulator
I653_09935	COG1388	LysM domain
I653_09935	COG3584	3D domain protein
I653_09940	COG0514	ATP-dependent DNA helicase (RecQ)
I653_09950	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I653_09955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I653_09970	COG0071	Belongs to the small heat shock protein (HSP20) family
I653_09995	COG1012	belongs to the aldehyde dehydrogenase family
I653_10000	COG1657	PFAM Prenyltransferase squalene oxidase
I653_10005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I653_10010	COG0733	neurotransmitter:sodium symporter activity
I653_10015	COG0385	Bile acid
I653_10020	COG0508	dehydrogenase complex catalyzes the overall conversion of
I653_10025	COG0567	Dehydrogenase, E1 component
I653_10030	COG4548	von Willebrand factor, type A
I653_10035	COG0714	Associated with various cellular activities
I653_10040	COG2032	superoxide dismutase activity
I653_10045	COG0791	NLP P60 protein
I653_10045	COG1388	LysM domain
I653_10050	COG1819	glycosyl
I653_10055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I653_10065	COG0534	Mate efflux family protein
I653_10070	COG1366	Belongs to the anti-sigma-factor antagonist family
I653_10075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I653_10080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I653_10090	COG2962	Rard protein
I653_10105	COG2610	gluconate transmembrane transporter activity
I653_10110	COG1942	4-Oxalocrotonate Tautomerase
I653_10120	COG1733	regulation of RNA biosynthetic process
I653_10125	COG0778	Nitroreductase
I653_10130	COG0400	carboxylic ester hydrolase activity
I653_10135	COG0346	lactoylglutathione lyase activity
I653_10145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I653_10150	COG3409	Peptidoglycan-binding domain 1 protein
I653_10150	COG0793	Belongs to the peptidase S41A family
I653_10155	COG2226	methyltransferase
I653_10165	COG1876	peptidase activity
I653_10170	COG0813	purine-nucleoside phosphorylase activity
I653_10185	COG0671	phosphoesterase, PA-phosphatase related
I653_10205	COG4479	Belongs to the UPF0346 family
I653_10215	COG1509	lysine 2,3-aminomutase activity
I653_10220	COG0456	acetyltransferase
I653_10225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I653_10230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I653_10235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I653_10240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I653_10255	COG0456	acetyltransferase
I653_10260	COG0463	Glycosyl transferase, family 2
I653_10275	COG4641	Protein conserved in bacteria
I653_10280	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
I653_10285	COG1086	Polysaccharide biosynthesis protein
I653_10290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I653_10295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I653_10300	COG1846	Transcriptional regulator
I653_10305	COG0534	Mate efflux family protein
I653_10315	COG4698	Protein conserved in bacteria
I653_10320	COG2755	lipolytic protein G-D-S-L family
I653_10325	COG1999	signal sequence binding
I653_10335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I653_10340	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I653_10345	COG1272	protein, Hemolysin III
I653_10350	COG0204	Acyl-transferase
I653_10355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I653_10360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I653_10365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I653_10375	COG2136	Putative SAM-dependent methyltransferase
I653_10375	COG2521	methyltransferase
I653_10385	COG0129	dihydroxy-acid dehydratase activity
I653_10400	COG1413	lyase activity
I653_10405	COG1418	mRNA catabolic process
I653_10410	COG0386	Belongs to the glutathione peroxidase family
I653_10415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I653_10420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I653_10425	COG1278	Cold shock
I653_10445	COG0328	RNA-DNA hybrid ribonuclease activity
I653_10450	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I653_10455	COG0328	RNA-DNA hybrid ribonuclease activity
I653_10465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I653_10485	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I653_10490	COG1755	Isoprenylcysteine carboxyl methyltransferase
I653_10495	COG3424	synthase
I653_10500	COG2233	PERMEase
I653_10505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I653_10510	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I653_10520	COG0800	Aldolase
I653_10525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I653_10530	COG1609	Transcriptional regulator
I653_10535	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I653_10540	COG1028	Short-chain dehydrogenase reductase Sdr
I653_10545	COG1199	ATP-dependent helicase activity
I653_10560	COG0116	Belongs to the methyltransferase superfamily
I653_10570	COG4474	Belongs to the UPF0398 family
I653_10585	COG3359	exonuclease
I653_10590	COG1205	dead DEAH box helicase
I653_10590	COG1111	helicase
I653_10595	COG2190	(PTS) system
I653_10600	COG0071	Belongs to the small heat shock protein (HSP20) family
I653_10635	COG3331	DNA recombination
I653_10640	COG4499	WXG100 protein secretion system (Wss), protein YukC
I653_10640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I653_10650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I653_10655	COG3935	DnaD domain protein
I653_10660	COG0017	Asparaginyl-tRNA synthetase
I653_10665	COG0436	Aminotransferase
I653_10670	COG5353	protein conserved in bacteria
I653_10680	COG1199	ATP-dependent helicase activity
I653_10680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I653_10685	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I653_10690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I653_10695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I653_10700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I653_10700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I653_10705	COG0617	tRNA 3'-terminal CCA addition
I653_10710	COG0438	transferase activity, transferring glycosyl groups
I653_10715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I653_10720	COG1803	Methylglyoxal synthase
I653_10725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I653_10730	COG1694	Mazg nucleotide pyrophosphohydrolase
I653_10735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I653_10745	COG4347	Protein of unknown function (DUF1405)
I653_10750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I653_10750	COG2010	Cytochrome c
I653_10755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I653_10760	COG0723	plastoquinol--plastocyanin reductase activity
I653_10770	COG5582	Belongs to the UPF0302 family
I653_10775	COG0457	Tetratricopeptide repeat
I653_10780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I653_10785	COG0287	Prephenate dehydrogenase
I653_10790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I653_10795	COG0159	tryptophan synthase activity
I653_10800	COG0133	tryptophan synthase activity
I653_10805	COG0135	phosphoribosylanthranilate isomerase activity
I653_10815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I653_10820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I653_10825	COG4401	Chorismate mutase type I
I653_10830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I653_10835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I653_10840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I653_10850	COG0105	UTP biosynthetic process
I653_10855	COG0142	geranyltranstransferase activity
I653_10860	COG2226	methyltransferase
I653_10865	COG0142	geranyltranstransferase activity
I653_10875	COG0302	gtp cyclohydrolase
I653_10880	COG0776	regulation of translation
I653_10885	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I653_10900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I653_10905	COG1160	GTP binding
I653_10930	COG1304	FMN binding
I653_10935	COG0539	negative regulation of cytoplasmic translation
I653_10940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I653_10950	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I653_10955	COG2959	enzyme of heme biosynthesis
I653_10960	COG3409	Peptidoglycan-binding domain 1 protein
I653_10960	COG3773	Cell wall hydrolase
I653_10965	COG2339	peptidase activity
I653_10970	COG0492	ferredoxin-NADP+ reductase activity
I653_10975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I653_10980	COG4862	establishment of competence for transformation
I653_10985	COG1408	metallophosphoesterase
I653_10995	COG1388	LysM domain
I653_11000	COG1266	CAAX protease self-immunity
I653_11005	COG0514	ATP-dependent DNA helicase (RecQ)
I653_11010	COG4955	Helix-turn-helix domain
I653_11015	COG1141	Ferredoxin
I653_11020	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I653_11030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I653_11035	COG0710	3-dehydroquinate dehydratase activity
I653_11045	COG1595	DNA-templated transcription, initiation
I653_11050	COG5002	protein histidine kinase activity
I653_11055	COG0745	RESPONSE REGULATOR receiver
I653_11060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I653_11065	COG1333	cytochrome c biogenesis protein
I653_11070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I653_11075	COG1187	pseudouridine synthase activity
I653_11080	COG0700	Nucleoside recognition
I653_11085	COG2715	membrane protein required for spore maturation
I653_11090	COG1686	Belongs to the peptidase S11 family
I653_11100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I653_11105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I653_11110	COG1547	Domain of unknown function (DUF309)
I653_11115	COG0456	acetyltransferase
I653_11120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I653_11125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I653_11125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I653_11130	COG0307	riboflavin synthase, alpha
I653_11135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I653_11135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I653_11145	COG0681	Belongs to the peptidase S26 family
I653_11150	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I653_11160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I653_11165	COG4086	secreted protein
I653_11170	COG0019	diaminopimelate decarboxylase activity
I653_11175	COG0697	spore germination
I653_11190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I653_11210	COG1191	sigma factor activity
I653_11215	COG2172	sigma factor antagonist activity
I653_11220	COG1366	Belongs to the anti-sigma-factor antagonist family
I653_11225	COG1686	Belongs to the peptidase S11 family
I653_11230	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I653_11235	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I653_11240	COG4974	Belongs to the 'phage' integrase family
I653_11250	COG0735	belongs to the Fur family
I653_11255	COG1300	Membrane
I653_11265	COG0281	malic enzyme
I653_11270	COG1757	Na H antiporter
I653_11275	COG1027	Aspartate ammonia-lyase
I653_11280	COG0252	asparaginase activity
I653_11285	COG1396	sequence-specific DNA binding
I653_11290	COG1379	DNA repair
I653_11295	COG0494	nUDIX hydrolase
I653_11305	COG0667	Aldo Keto reductase
I653_11315	COG1073	alpha beta
I653_11325	COG4918	Iron-sulphur cluster biosynthesis
I653_11330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I653_11330	COG0456	acetyltransferase
I653_11335	COG2329	Antibiotic biosynthesis monooxygenase
I653_11340	COG0456	acetyltransferase
I653_11350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I653_11365	COG2211	Major facilitator Superfamily
I653_11375	COG0346	lactoylglutathione lyase activity
I653_11380	COG1072	(Pantothenic acid kinase))
I653_11385	COG3048	D-serine ammonia-lyase activity
I653_11390	COG0300	oxidoreductase activity
I653_11395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I653_11400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I653_11405	COG4187	Peptidase family M20/M25/M40
I653_11410	COG1902	pentaerythritol trinitrate reductase activity
I653_11415	COG0596	Alpha beta hydrolase
I653_11425	COG1234	tRNA 3'-trailer cleavage
I653_11430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I653_11435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I653_11440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I653_11450	COG0706	membrane insertase activity
I653_11455	COG3361	conserved protein (COG2071)
I653_11460	COG2195	Cleaves the N-terminal amino acid of tripeptides
I653_11465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I653_11470	COG0346	lactoylglutathione lyase activity
I653_11480	COG1376	ErfK ybiS ycfS ynhG family protein
I653_11485	COG4129	membrane
I653_11490	COG1126	abc transporter atp-binding protein
I653_11495	COG0765	amino acid transport
I653_11500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I653_11510	COG1597	lipid kinase activity
I653_11515	COG2814	Major facilitator Superfamily
I653_11520	COG0789	Transcriptional regulator
I653_11520	COG4978	Transcriptional regulator
I653_11525	COG0508	dehydrogenase complex catalyzes the overall conversion of
I653_11530	COG0022	dehydrogenase e1 component
I653_11535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I653_11540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I653_11545	COG3426	butyrate kinase activity
I653_11550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I653_11555	COG0280	phosphate acetyltransferase
I653_11560	COG3829	transcription factor binding
I653_11560	COG3290	protein histidine kinase activity
I653_11570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I653_11575	COG2079	MmgE PrpD family protein
I653_11580	COG0372	Belongs to the citrate synthase family
I653_11585	COG1960	acyl-CoA dehydrogenase activity
I653_11590	COG1250	3-hydroxyacyl-CoA dehydrogenase
I653_11595	COG0183	Belongs to the thiolase family
I653_11600	COG0584	glycerophosphoryl diester phosphodiesterase
I653_11605	COG0860	N-Acetylmuramoyl-L-alanine amidase
I653_11620	COG1902	pentaerythritol trinitrate reductase activity
I653_11630	COG0745	RESPONSE REGULATOR receiver
I653_11635	COG0750	zinc metalloprotease
I653_11640	COG0497	DNA recombination
I653_11645	COG1438	arginine binding
I653_11650	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I653_11655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I653_11660	COG0142	geranyltranstransferase activity
I653_11665	COG1722	exodeoxyribonuclease VII activity
I653_11670	COG1570	exodeoxyribonuclease VII activity
I653_11675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I653_11680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I653_11685	COG1302	Protein conserved in bacteria
I653_11690	COG0439	Biotin carboxylase
I653_11695	COG0511	ligase activity, forming carbon-carbon bonds
I653_11735	COG3854	ATPases associated with a variety of cellular activities
I653_11745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I653_11750	COG0006	proline dipeptidase activity
I653_11755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I653_11765	COG3872	metal-dependent enzyme
I653_11775	COG1752	Esterase of the alpha-beta hydrolase superfamily
I653_11780	COG1321	iron dependent repressor
I653_11785	COG0095	Lipoate-protein ligase
I653_11790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I653_11795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I653_11800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I653_11805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I653_11810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I653_11825	COG1396	sequence-specific DNA binding
I653_11835	COG0681	Belongs to the peptidase S26 family
I653_11860	COG4940	Competence protein ComGF
I653_11870	COG4970	Tfp pilus assembly protein FimT
I653_11875	COG4537	Required for transformation and DNA binding
I653_11880	COG1459	type II secretion system
I653_11885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I653_11890	COG0598	Magnesium transport protein CorA
I653_11895	COG1253	flavin adenine dinucleotide binding
I653_11900	COG1366	Belongs to the anti-sigma-factor antagonist family
I653_11905	COG1393	Belongs to the ArsC family
I653_11915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I653_11925	COG0011	TIGRFAM Protein of
I653_11935	COG2866	Carboxypeptidase
I653_11940	COG1368	sulfuric ester hydrolase activity
I653_11945	COG1940	carbohydrate kinase activity
I653_11950	COG4483	Protein conserved in bacteria
I653_11955	COG0705	Rhomboid family
I653_11955	COG0457	Tetratricopeptide repeat
I653_11965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I653_11970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I653_11975	COG0438	transferase activity, transferring glycosyl groups
I653_11990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I653_11995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I653_12000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I653_12005	COG0581	inorganic phosphate transmembrane transporter activity
I653_12010	COG0573	inorganic phosphate transmembrane transporter activity
I653_12015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I653_12025	COG0477	Major facilitator Superfamily
I653_12030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I653_12035	COG2839	Protein conserved in bacteria
I653_12040	COG5521	maltodextrose utilization protein MalA
I653_12045	COG1388	LysM domain
I653_12050	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I653_12055	COG4709	membrane
I653_12060	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I653_12065	COG0735	belongs to the Fur family
I653_12070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I653_12080	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I653_12085	COG0513	Belongs to the DEAD box helicase family
I653_12095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I653_12100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I653_12105	COG2384	SAM-dependent methyltransferase
I653_12110	COG2010	Cytochrome c
I653_12115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I653_12120	COG0358	DNA primase activity
I653_12125	COG1671	Belongs to the UPF0178 family
I653_12130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I653_12135	COG0517	IMP dehydrogenase activity
I653_12140	COG0751	glycine-tRNA ligase activity
I653_12145	COG0752	glycyl-tRNA synthetase alpha subunit
I653_12150	COG1381	Involved in DNA repair and RecF pathway recombination
I653_12160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I653_12165	COG0295	cytidine deaminase activity
I653_12170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I653_12175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I653_12180	COG1480	7TM receptor with intracellular HD hydrolase
I653_12190	COG1702	phosphate starvation-inducible protein PhoH
I653_12195	COG0561	phosphatase activity
I653_12210	COG4864	UPF0365 protein
I653_12215	COG1030	water channel activity
I653_12220	COG1610	YqeY-like protein
I653_12225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I653_12230	COG1283	sodium-dependent phosphate transmembrane transporter activity
I653_12235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I653_12240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I653_12245	COG2264	protein methyltransferase activity
I653_12250	COG0484	heat shock protein binding
I653_12255	COG0443	Heat shock 70 kDa protein
I653_12260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I653_12265	COG1420	regulation of RNA biosynthetic process
I653_12270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I653_12275	COG0481	GTPase activity
I653_12285	COG0860	N-Acetylmuramoyl-L-alanine amidase
I653_12290	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I653_12295	COG0268	Binds directly to 16S ribosomal RNA
I653_12300	COG1466	dna polymerase III delta subunit
I653_12310	COG2333	competence protein COMEC
I653_12310	COG0658	competence protein
I653_12315	COG2131	deaminase
I653_12320	COG1555	photosystem II stabilization
I653_12320	COG1596	polysaccharide export
I653_12325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I653_12330	COG2226	methyltransferase
I653_12335	COG0799	negative regulation of ribosome biogenesis
I653_12340	COG1713	HD superfamily hydrolase involved in NAD metabolism
I653_12345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I653_12350	COG1534	Rna-binding protein
I653_12355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I653_12360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I653_12365	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I653_12380	COG2755	lipolytic protein G-D-S-L family
I653_12385	COG3409	Peptidoglycan-binding domain 1 protein
I653_12385	COG5632	N-Acetylmuramoyl-L-alanine amidase
I653_12390	COG0398	Pfam SNARE associated Golgi protein
I653_12395	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I653_12405	COG3209	COG3209 Rhs family protein
I653_12420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I653_12430	COG3223	Belongs to the PsiE family
I653_12435	COG0642	Histidine kinase
I653_12435	COG5002	protein histidine kinase activity
I653_12440	COG0745	RESPONSE REGULATOR receiver
I653_12445	COG2311	Membrane
I653_12455	COG0454	-acetyltransferase
I653_12460	COG1733	regulation of RNA biosynthetic process
I653_12465	COG1028	Short-chain dehydrogenase reductase Sdr
I653_12500	COG4824	toxin secretion phage lysis holin
I653_12520	COG0563	adenylate kinase activity
I653_12525	COG2856	Zn peptidase
I653_12530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I653_12540	COG2249	NAD(P)H dehydrogenase (quinone) activity
I653_12550	COG1846	Transcriptional regulator
I653_12555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I653_12565	COG0457	Tetratricopeptide repeat
I653_12570	COG5444	nuclease activity
I653_12595	COG4978	Transcriptional regulator
I653_12595	COG0789	Transcriptional regulator
I653_12600	COG2814	Major facilitator Superfamily
I653_12605	COG0456	acetyltransferase
I653_12610	COG1253	flavin adenine dinucleotide binding
I653_12620	COG0697	spore germination
I653_12625	COG0583	DNA-binding transcription factor activity
I653_12630	COG2072	flavoprotein involved in K transport
I653_12635	COG1230	cation diffusion facilitator family transporter
I653_12640	COG1942	4-Oxalocrotonate Tautomerase
I653_12645	COG0583	DNA-binding transcription factor activity
I653_12655	COG1114	Component of the transport system for branched-chain amino acids
I653_12660	COG1687	branched-chain amino acid
I653_12665	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I653_12670	COG1522	sequence-specific DNA binding
I653_12675	COG2732	(Barnase) inhibitor
I653_12680	COG2732	(Barnase) inhibitor
I653_12685	COG2124	cytochrome p450
I653_12695	COG1335	isochorismatase
I653_12710	COG2318	DinB family
I653_12720	COG2070	2-Nitropropane dioxygenase
I653_12725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I653_12735	COG3443	Belongs to the bacterial solute-binding protein 9 family
I653_12740	COG1595	DNA-templated transcription, initiation
I653_12745	COG0667	Aldo Keto reductase
I653_12750	COG3409	Peptidoglycan-binding domain 1 protein
I653_12755	COG5566	PFAM Mor transcription activator
I653_12760	COG0596	Alpha beta hydrolase
I653_12765	COG4991	sh3 domain protein
I653_12770	COG4991	sh3 domain protein
I653_12775	COG0346	lactoylglutathione lyase activity
I653_12785	COG5577	PFAM Coat F domain
I653_12790	COG1063	alcohol dehydrogenase
I653_12800	COG5577	PFAM Coat F domain
I653_12805	COG0789	Transcriptional regulator
I653_12815	COG1064	alcohol dehydrogenase
I653_12820	COG0693	protein deglycase activity
I653_12825	COG1621	beta-fructofuranosidase activity
I653_12830	COG3716	PTS system mannose fructose sorbose family IID component
I653_12835	COG3715	PTS system
I653_12840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_12845	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I653_12850	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I653_12850	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I653_12855	COG1113	amino acid transport
I653_12860	COG1280	lysine exporter protein (LysE YggA)
I653_12865	COG1378	Sugar-specific transcriptional regulator TrmB
I653_12870	COG1595	DNA-templated transcription, initiation
I653_12880	COG2755	lipolytic protein G-D-S-L family
I653_12880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I653_12890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I653_12890	COG2124	cytochrome p450
I653_12895	COG1309	transcriptional regulator
I653_12900	COG2226	methyltransferase
I653_12915	COG2116	formate transmembrane transporter activity
I653_12920	COG5609	conserved protein (DUF2294)
I653_12925	COG3383	formate dehydrogenase (NAD+) activity
I653_12930	COG2427	Protein of unknown function (DUF1641)
I653_12940	COG0626	cystathionine gamma-synthase activity
I653_12945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I653_12950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I653_12955	COG2226	methyltransferase
I653_12970	COG0768	penicillin binding
I653_12975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I653_12980	COG0572	uridine kinase
I653_13000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I653_13005	COG3906	Belongs to the UPF0473 family
I653_13010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I653_13015	COG4472	Bacterial protein of unknown function (DUF965)
I653_13020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I653_13025	COG0628	permease
I653_13030	COG1126	abc transporter atp-binding protein
I653_13035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I653_13040	COG0765	amino acid transport
I653_13045	COG0765	amino acid transport
I653_13060	COG3881	PFAM PRC-barrel domain
I653_13065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I653_13070	COG0457	Tetratricopeptide repeat
I653_13075	COG0482	sulfurtransferase activity
I653_13080	COG1104	cysteine desulfurase activity
I653_13085	COG1959	2 iron, 2 sulfur cluster binding
I653_13090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I653_13095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I653_13105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I653_13110	COG0124	histidyl-tRNA synthetase
I653_13120	COG4991	sh3 domain protein
I653_13120	COG0860	N-Acetylmuramoyl-L-alanine amidase
I653_13120	COG3103	Sh3 type 3 domain protein
I653_13125	COG1490	D-aminoacyl-tRNA deacylase activity
I653_13130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I653_13135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I653_13140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I653_13140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I653_13145	COG5416	Lipopolysaccharide assembly protein A domain
I653_13150	COG0490	domain, Protein
I653_13155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I653_13155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I653_13165	COG2244	polysaccharide biosynthetic process
I653_13170	COG2323	membrane
I653_13180	COG1862	Preprotein translocase
I653_13185	COG0343	queuine tRNA-ribosyltransferase activity
I653_13190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I653_13200	COG2255	four-way junction helicase activity
I653_13205	COG0632	four-way junction helicase activity
I653_13215	COG2814	Major facilitator Superfamily
I653_13220	COG0673	inositol 2-dehydrogenase activity
I653_13225	COG2112	serine threonine protein kinase
I653_13245	COG1115	amino acid carrier protein
I653_13250	COG0217	transcriptional regulatory protein
I653_13260	COG1388	LysM domain
I653_13265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I653_13270	COG0157	Belongs to the NadC ModD family
I653_13275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I653_13280	COG1104	cysteine desulfurase activity
I653_13285	COG1827	regulation of RNA biosynthetic process
I653_13290	COG0077	Prephenate dehydratase
I653_13295	COG4492	Belongs to the UPF0735 family
I653_13300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I653_13305	COG3290	protein histidine kinase activity
I653_13315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I653_13320	COG2868	ribosomal protein
I653_13325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I653_13330	COG1994	Peptidase M50
I653_13335	COG0739	heme binding
I653_13340	COG2894	cell division
I653_13345	COG0850	regulation of cytokinetic process
I653_13350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I653_13355	COG1792	Involved in formation and maintenance of cell shape
I653_13360	COG1077	Cell shape determining protein MreB Mrl
I653_13365	COG2003	Belongs to the UPF0758 family
I653_13370	COG0424	maF-like protein
I653_13380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I653_13385	COG0285	dihydrofolate synthase activity
I653_13390	COG0525	valine-tRNA ligase activity
I653_13400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I653_13405	COG1388	LysM domain
I653_13410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I653_13415	COG0113	porphobilinogen synthase activity
I653_13420	COG1587	Uroporphyrinogen-III synthase
I653_13425	COG0181	hydroxymethylbilane synthase activity
I653_13430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I653_13435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I653_13445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I653_13450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I653_13455	COG1067	ATP-dependent peptidase activity
I653_13455	COG0470	DNA polymerase III
I653_13460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I653_13465	COG0544	peptidyl-prolyl cis-trans isomerase activity
I653_13470	COG1477	protein flavinylation
I653_13470	COG0457	Tetratricopeptide repeat
I653_13475	COG0066	3-isopropylmalate dehydratase activity
I653_13480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I653_13485	COG0473	3-isopropylmalate dehydrogenase activity
I653_13490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I653_13495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I653_13500	COG0440	acetolactate synthase activity
I653_13505	COG0028	Belongs to the TPP enzyme family
I653_13515	COG0454	-acetyltransferase
I653_13520	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I653_13525	COG0622	Phosphoesterase
I653_13530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I653_13535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I653_13540	COG5401	PFAM Sporulation and spore germination
I653_13545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I653_13550	COG1846	Transcriptional regulator
I653_13555	COG2197	response regulator
I653_13560	COG0824	Thioesterase
I653_13565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I653_13570	COG1053	succinate dehydrogenase
I653_13575	COG2009	succinate dehydrogenase
I653_13585	COG1719	4-vinyl reductase, 4VR
I653_13590	COG0527	aspartate kinase activity
I653_13595	COG0322	excinuclease ABC activity
I653_13600	COG3118	belongs to the thioredoxin family
I653_13605	COG3534	alpha-L-arabinofuranosidase
I653_13610	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I653_13615	COG2086	electron transfer activity
I653_13620	COG1024	Enoyl-CoA hydratase
I653_13625	COG1309	transcriptional regulator
I653_13630	COG0318	PFAM AMP-dependent synthetase and ligase
I653_13635	COG3766	membrane
I653_13640	COG1193	negative regulation of DNA recombination
I653_13645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I653_13645	COG1796	DNA polymerase
I653_13650	COG1286	toxin biosynthetic process
I653_13655	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I653_13660	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I653_13665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I653_13665	COG0072	phenylalanine-tRNA ligase activity
I653_13670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I653_13680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I653_13690	COG3835	regulator
I653_13695	COG0277	FAD linked oxidase domain protein
I653_13700	COG0247	lactate metabolic process
I653_13705	COG0346	lactoylglutathione lyase activity
I653_13710	COG1966	Carbon starvation protein
I653_13715	COG3534	alpha-L-arabinofuranosidase
I653_13720	COG0395	ABC-type sugar transport system, permease component
I653_13725	COG1175	transmembrane transport
I653_13730	COG1653	transport
I653_13735	COG0371	Dehydrogenase
I653_13740	COG0647	UMP catabolic process
I653_13745	COG0235	Class ii aldolase
I653_13750	COG1069	ribulokinase activity
I653_13755	COG2160	L-arabinose isomerase activity
I653_13760	COG3507	Belongs to the glycosyl hydrolase 43 family
I653_13765	COG1363	Peptidase, m42
I653_13775	COG3326	Membrane
I653_13780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I653_13785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I653_13790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I653_13800	COG1346	cytolysis
I653_13805	COG1380	Effector of murein hydrolase LrgA
I653_13810	COG3279	Response regulator of the LytR AlgR family
I653_13815	COG3275	phosphorelay sensor kinase activity
I653_13825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I653_13835	COG0398	Pfam SNARE associated Golgi protein
I653_13840	COG1484	DNA-dependent DNA replication
I653_13845	COG3611	Membrane attachment protein
I653_13850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I653_13855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I653_13860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I653_13865	COG1733	regulation of RNA biosynthetic process
I653_13870	COG2814	Major facilitator Superfamily
I653_13875	COG0656	L-ascorbic acid biosynthetic process
I653_13880	COG0237	dephospho-CoA kinase activity
I653_13885	COG1971	Probably functions as a manganese efflux pump
I653_13890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I653_13895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I653_13895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I653_13900	COG5002	protein histidine kinase activity
I653_13905	COG0745	RESPONSE REGULATOR receiver
I653_13910	COG0039	L-malate dehydrogenase activity
I653_13915	COG0538	isocitrate dehydrogenase activity
I653_13920	COG0372	Belongs to the citrate synthase family
I653_13925	COG2707	UPF0756 membrane protein
I653_13930	COG0628	permease
I653_13935	COG3030	protein affecting phage T7 exclusion by the F plasmid
I653_13940	COG0469	pyruvate kinase activity
I653_13945	COG0205	6-phosphofructokinase activity
I653_13950	COG0825	malonyl-CoA metabolic process
I653_13955	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I653_13960	COG0281	malic enzyme
I653_13965	COG0587	DNA-directed DNA polymerase activity
I653_13985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I653_13995	COG4109	DRTGG domain
I653_14000	COG0730	response to heat
I653_14005	COG1473	amidohydrolase
I653_14010	COG0196	riboflavin kinase activity
I653_14015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I653_14020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I653_14025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I653_14030	COG1126	abc transporter atp-binding protein
I653_14035	COG0765	amino acid transport
I653_14040	COG0765	amino acid transport
I653_14045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I653_14050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I653_14055	COG0454	-acetyltransferase
I653_14060	COG0583	DNA-binding transcription factor activity
I653_14065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I653_14070	COG1028	Short-chain dehydrogenase reductase Sdr
I653_14080	COG0165	Argininosuccinate lyase
I653_14085	COG0137	argininosuccinate synthase activity
I653_14090	COG0521	Mo-molybdopterin cofactor biosynthetic process
I653_14095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I653_14100	COG0827	DNA restriction-modification system
I653_14105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I653_14110	COG3874	Sporulation protein YtfJ
I653_14120	COG1714	RDD family
I653_14125	COG0616	signal peptide processing
I653_14135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I653_14140	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I653_14145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I653_14155	COG0301	tRNA thio-modification
I653_14160	COG1104	cysteine desulfurase activity
I653_14165	COG1114	Component of the transport system for branched-chain amino acids
I653_14170	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I653_14175	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I653_14180	COG1309	transcriptional regulator
I653_14185	COG1956	GAF domain-containing protein
I653_14190	COG2203	Gaf domain
I653_14190	COG2199	diguanylate cyclase activity
I653_14195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I653_14205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I653_14210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I653_14215	COG0454	-acetyltransferase
I653_14220	COG0517	IMP dehydrogenase activity
I653_14225	COG0123	including yeast histone deacetylase and acetoin utilization protein
I653_14230	COG1360	Flagellar Motor Protein
I653_14235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I653_14240	COG1609	Transcriptional regulator
I653_14245	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I653_14245	COG1605	Chorismate mutase
I653_14250	COG3118	belongs to the thioredoxin family
I653_14255	COG4980	gas vesicle protein
I653_14260	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I653_14265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I653_14270	COG1674	ftsk spoiiie
I653_14275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I653_14280	COG4848	Belongs to the UPF0354 family
I653_14285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I653_14295	COG1363	Peptidase, m42
I653_14300	COG5584	Small secreted protein
I653_14305	COG0281	malic enzyme
I653_14310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I653_14315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I653_14325	COG0510	thiamine kinase activity
I653_14330	COG1523	belongs to the glycosyl hydrolase 13 family
I653_14335	COG1597	lipid kinase activity
I653_14345	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I653_14350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I653_14355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I653_14360	COG2252	PERMEase
I653_14365	COG4473	ABC transporter
I653_14370	COG1131	(ABC) transporter
I653_14375	COG1349	DNA-binding transcription factor activity
I653_14380	COG1187	pseudouridine synthase activity
I653_14385	COG2244	polysaccharide biosynthetic process
I653_14390	COG2081	HI0933 family
I653_14395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I653_14405	COG5578	integral membrane protein
I653_14410	COG0673	inositol 2-dehydrogenase activity
I653_14415	COG1653	transport
I653_14420	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I653_14425	COG4209	transmembrane transport
I653_14430	COG2207	Transcriptional regulator
I653_14435	COG1653	transport
I653_14440	COG0395	ABC-type sugar transport system, permease component
I653_14445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I653_14450	COG2124	cytochrome p450
I653_14455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I653_14465	COG0156	8-amino-7-oxononanoate synthase activity
I653_14470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I653_14480	COG1073	alpha beta
I653_14505	COG1486	melibiose metabolic process
I653_14510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I653_14515	COG0495	leucyl-tRNA aminoacylation
I653_14525	COG2202	Pas domain
I653_14525	COG1366	Belongs to the anti-sigma-factor antagonist family
I653_14540	COG2433	Pfam Transposase IS66
I653_14545	COG0577	efflux transmembrane transporter activity
I653_14550	COG1136	(ABC) transporter
I653_14555	COG2205	protein histidine kinase activity
I653_14560	COG0745	RESPONSE REGULATOR receiver
I653_14565	COG0577	efflux transmembrane transporter activity
I653_14570	COG1136	(ABC) transporter
I653_14585	COG1131	(ABC) transporter
I653_14590	COG1725	Transcriptional regulator
I653_14605	COG1242	4 iron, 4 sulfur cluster binding
I653_14610	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I653_14620	COG2267	carboxylic ester hydrolase activity
I653_14625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I653_14630	COG1113	amino acid transport
I653_14635	COG0367	asparagine synthase
I653_14640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I653_14645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I653_14655	COG1506	peptidase
I653_14660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I653_14665	COG1116	anion transmembrane transporter activity
I653_14670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I653_14675	COG0494	nUDIX hydrolase
I653_14680	COG4824	toxin secretion phage lysis holin
I653_14685	COG0783	Belongs to the Dps family
I653_14700	COG1854	S-ribosylhomocysteine lyase activity
I653_14705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I653_14710	COG0288	reversible hydration of carbon dioxide
I653_14715	COG0254	rRNA binding
I653_14720	COG1271	oxidase subunit
I653_14725	COG1294	oxidase, subunit
I653_14735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I653_14740	COG1321	iron dependent repressor
I653_14740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I653_14745	COG1121	(ABC) transporter
I653_14750	COG0803	Belongs to the bacterial solute-binding protein 9 family
I653_14755	COG4948	Mandelate Racemase Muconate Lactonizing
I653_14760	COG0318	PFAM AMP-dependent synthetase and ligase
I653_14765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I653_14770	COG0596	Alpha beta hydrolase
I653_14775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I653_14780	COG1169	isochorismate synthase
I653_14790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I653_14795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I653_14800	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I653_14805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I653_14810	COG0438	transferase activity, transferring glycosyl groups
I653_14820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I653_14825	COG0438	transferase activity, transferring glycosyl groups
I653_14830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I653_14835	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I653_14840	COG0058	SHG alpha-glucan phosphorylase activity
I653_14845	COG0297	glycogen (starch) synthase activity
I653_14850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I653_14855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I653_14860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I653_14875	COG3859	Proton-coupled thiamine transporter YuaJ
I653_14880	COG1247	-acetyltransferase
I653_14885	COG1247	-acetyltransferase
I653_14890	COG2268	Band 7 protein
I653_14895	COG1585	Membrane protein implicated in regulation of membrane protease activity
I653_14900	COG2318	DinB family
I653_14910	COG1454	alcohol dehydrogenase
I653_14920	COG1510	regulation of RNA biosynthetic process
I653_14930	COG0569	domain protein
I653_14935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I653_14940	COG4682	membrane
I653_14945	COG1705	Flagellar rod assembly protein muramidase FlgJ
I653_14950	COG0477	Major facilitator Superfamily
I653_14955	COG5553	Cysteine dioxygenase type I
I653_14960	COG1968	undecaprenyl-diphosphatase activity
I653_14965	COG0628	permease
I653_14970	COG0673	inositol 2-dehydrogenase activity
I653_14975	COG4806	L-rhamnose isomerase
I653_14980	COG3254	rhamnose metabolic process
I653_14985	COG1070	Carbohydrate kinase
I653_14990	COG1349	DNA-binding transcription factor activity
I653_14995	COG1028	Short-chain dehydrogenase reductase Sdr
I653_14995	COG3347	Dehydrogenase
I653_15005	COG0840	transmembrane signaling receptor activity
I653_15010	COG0840	transmembrane signaling receptor activity
I653_15015	COG0840	transmembrane signaling receptor activity
I653_15020	COG0840	transmembrane signaling receptor activity
I653_15035	COG0432	Pfam Uncharacterised protein family UPF0047
I653_15040	COG0366	Alpha amylase catalytic
I653_15045	COG1253	flavin adenine dinucleotide binding
I653_15050	COG2738	Putative neutral zinc metallopeptidase
I653_15065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I653_15080	COG0166	Belongs to the GPI family
I653_15085	COG1979	alcohol dehydrogenase
I653_15090	COG1979	alcohol dehydrogenase
I653_15100	COG2155	Conserved Protein
I653_15105	COG1098	S1 RNA binding domain
I653_15110	COG0436	Aminotransferase
I653_15115	COG1522	sequence-specific DNA binding
I653_15120	COG2267	carboxylic ester hydrolase activity
I653_15130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I653_15135	COG2205	protein histidine kinase activity
I653_15145	COG5018	Exonuclease
I653_15155	COG2814	Major facilitator Superfamily
I653_15160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I653_15165	COG3011	Protein conserved in bacteria
I653_15175	COG3290	protein histidine kinase activity
I653_15180	COG4565	transcriptional regulatory protein
I653_15205	COG3493	citrate carrier protein
I653_15215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I653_15215	COG2111	Na H antiporter
I653_15220	COG2111	Na H antiporter
I653_15225	COG1006	Multisubunit Na H antiporter MnhC subunit
I653_15230	COG0651	ATP synthesis coupled electron transport
I653_15235	COG1863	multisubunit Na H antiporter MnhE subunit
I653_15240	COG2212	antiporter activity
I653_15245	COG1320	monovalent cation:proton antiporter activity
I653_15250	COG2050	protein possibly involved in aromatic compounds catabolism
I653_15255	COG2197	response regulator
I653_15260	COG4585	Histidine kinase
I653_15270	COG0142	geranyltranstransferase activity
I653_15285	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I653_15290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I653_15295	COG1335	isochorismatase
I653_15300	COG5506	Protein of unknown function (DUF1694)
I653_15315	COG0628	permease
I653_15330	COG1418	mRNA catabolic process
I653_15335	COG1028	Short-chain dehydrogenase reductase Sdr
I653_15345	COG1511	domain protein
I653_15360	COG4499	WXG100 protein secretion system (Wss), protein YukC
I653_15365	COG5417	Belongs to the EsaB family
I653_15370	COG4842	Belongs to the WXG100 family
I653_15375	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I653_15375	COG2508	Transcriptional regulator
I653_15380	COG0686	Belongs to the AlaDH PNT family
I653_15385	COG5634	Uncharacterized conserved protein (DUF2278)
I653_15390	COG3251	PFAM MbtH domain protein
I653_15395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_15400	COG1535	isochorismatase
I653_15400	COG3433	isochorismatase activity
I653_15405	COG1021	2,3-dihydroxybenzoate-AMP ligase
I653_15410	COG1169	isochorismate synthase
I653_15415	COG1028	Short-chain dehydrogenase reductase Sdr
I653_15420	COG2819	hydrolase of the alpha beta superfamily
I653_15425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I653_15430	COG1268	BioY protein
I653_15435	COG2056	Na+-H+ antiporter family
I653_15440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I653_15445	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I653_15450	COG3584	3D domain protein
I653_15465	COG1252	NADH dehydrogenase
I653_15470	COG0492	ferredoxin-NADP+ reductase activity
I653_15480	COG0516	GMP reductase activity
I653_15485	COG2808	Putative FMN-binding domain
I653_15490	COG0456	acetyltransferase
I653_15495	COG0316	Belongs to the HesB IscA family
I653_15500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I653_15505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I653_15510	COG4844	belongs to the
I653_15515	COG1252	NADH dehydrogenase
I653_15520	COG4837	Protein of unknown function (DUF1462)
I653_15525	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I653_15530	COG1506	peptidase
I653_15530	COG4946	Tricorn protease homolog
I653_15530	COG0823	Involved in the tonB-independent uptake of proteins
I653_15535	COG0083	homoserine kinase activity
I653_15540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I653_15545	COG0460	homoserine dehydrogenase
I653_15550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I653_15555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I653_15560	COG0647	UMP catabolic process
I653_15565	COG2445	Protein of unknown function DUF86
I653_15570	COG4470	Protein conserved in bacteria
I653_15580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I653_15585	COG0739	heme binding
I653_15595	COG3377	Domain of unknown function (DUF1805)
I653_15600	COG0737	Belongs to the 5'-nucleotidase family
I653_15605	COG0730	response to heat
I653_15610	COG1801	Protein of unknown function DUF72
I653_15620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I653_15625	COG2508	Transcriptional regulator
I653_15630	COG2233	PERMEase
I653_15635	COG2233	PERMEase
I653_15640	COG3195	allantoin biosynthetic process
I653_15640	COG3648	Uricase
I653_15645	COG2351	hydroxyisourate hydrolase activity
I653_15660	COG2080	2 iron, 2 sulfur cluster binding
I653_15665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I653_15670	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I653_15675	COG2068	MobA-Related Protein
I653_15680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I653_15685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I653_15690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I653_15695	COG2356	endonuclease I
I653_15700	COG3842	ATPase activity
I653_15705	COG2188	Transcriptional regulator
I653_15710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I653_15715	COG0395	ABC-type sugar transport system, permease component
I653_15720	COG1175	transmembrane transport
I653_15725	COG1653	transport
I653_15730	COG2222	sugar isomerase
I653_15735	COG0322	excinuclease ABC activity
I653_15740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I653_15755	COG0346	lactoylglutathione lyase activity
I653_15760	COG0640	Transcriptional regulator
I653_15765	COG0719	Fe-S assembly protein
I653_15770	COG0822	iron-sulfur transferase activity
I653_15775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I653_15780	COG0719	Fe-S assembly protein
I653_15785	COG0396	ATPase activity
I653_15795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I653_15800	COG1464	Belongs to the NlpA lipoprotein family
I653_15805	COG2011	ABC-type metal ion transport system permease component
I653_15810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I653_15820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I653_15825	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I653_15840	COG0509	glycine decarboxylation via glycine cleavage system
I653_15845	COG1393	Belongs to the ArsC family
I653_15850	COG1960	acyl-CoA dehydrogenase activity
I653_15855	COG0183	Belongs to the thiolase family
I653_15860	COG1250	3-hydroxyacyl-CoA dehydrogenase
I653_15860	COG1024	Enoyl-CoA hydratase
I653_15870	COG0506	proline dehydrogenase activity
I653_15880	COG5577	PFAM Coat F domain
I653_15885	COG1846	Transcriptional regulator
I653_15890	COG0477	Major facilitator Superfamily
I653_15895	COG1942	4-Oxalocrotonate Tautomerase
I653_15900	COG1028	Short-chain dehydrogenase reductase Sdr
I653_15905	COG0583	DNA-binding transcription factor activity
I653_15915	COG1120	ATPase activity
I653_15930	COG1028	Short-chain dehydrogenase reductase Sdr
I653_15935	COG0783	Belongs to the Dps family
I653_15940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I653_15945	COG0745	RESPONSE REGULATOR receiver
I653_15950	COG2205	protein histidine kinase activity
I653_15950	COG2770	Histidine kinase
I653_15960	COG1309	transcriptional regulator
I653_15965	COG0114	fumarate hydratase activity
I653_15975	COG0697	spore germination
I653_15980	COG0814	amino acid
I653_15990	COG2197	response regulator
I653_15995	COG4585	Histidine kinase
I653_16000	COG4758	membrane
I653_16005	COG3595	metallopeptidase activity
I653_16010	COG1842	Phage shock protein A
I653_16015	COG4758	membrane
I653_16035	COG2096	Adenosyltransferase
I653_16040	COG1120	ATPase activity
I653_16045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_16050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I653_16055	COG1028	Short-chain dehydrogenase reductase Sdr
I653_16060	COG3386	PFAM SMP-30 Gluconolaconase
I653_16065	COG2205	protein histidine kinase activity
I653_16070	COG0745	RESPONSE REGULATOR receiver
I653_16080	COG1191	sigma factor activity
I653_16090	COG2140	Oxalate decarboxylase
I653_16100	COG0577	efflux transmembrane transporter activity
I653_16105	COG1136	(ABC) transporter
I653_16110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I653_16115	COG1120	ATPase activity
I653_16120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_16125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I653_16130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I653_16135	COG0531	amino acid
I653_16145	COG1988	membrane-bound metal-dependent
I653_16150	COG1368	sulfuric ester hydrolase activity
I653_16155	COG1910	domain protein
I653_16160	COG0725	ABC transporter, periplasmic molybdate-binding protein
I653_16165	COG4149	molybdate abc transporter
I653_16170	COG0656	L-ascorbic acid biosynthetic process
I653_16180	COG0025	NhaP-type Na H and K H
I653_16185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I653_16190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I653_16195	COG3973	AAA domain
I653_16205	COG2860	membrane
I653_16210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I653_16215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I653_16220	COG2217	Heavy metal translocating P-type atpase
I653_16225	COG2217	Heavy metal translocating P-type atpase
I653_16230	COG2608	mercury ion transmembrane transporter activity
I653_16235	COG1937	Protein conserved in bacteria
I653_16240	COG0673	inositol 2-dehydrogenase activity
I653_16245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I653_16250	COG1289	transmembrane transporter activity
I653_16260	COG2076	Multidrug Resistance protein
I653_16265	COG1309	transcriptional regulator
I653_16270	COG1028	Short-chain dehydrogenase reductase Sdr
I653_16275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I653_16280	COG0557	exoribonuclease II activity
I653_16285	COG1647	Serine aminopeptidase, S33
I653_16290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I653_16295	COG0596	Alpha beta hydrolase
I653_16300	COG1476	TRANSCRIPTIONal
I653_16305	COG1396	sequence-specific DNA binding
I653_16310	COG1396	sequence-specific DNA binding
I653_16315	COG1733	regulation of RNA biosynthetic process
I653_16340	COG1174	glycine betaine transport
I653_16345	COG1732	Glycine betaine
I653_16350	COG1174	glycine betaine transport
I653_16355	COG0517	IMP dehydrogenase activity
I653_16355	COG1125	glycine betaine transport
I653_16360	COG1510	regulation of RNA biosynthetic process
I653_16365	COG1174	glycine betaine transport
I653_16370	COG1732	Glycine betaine
I653_16375	COG1174	glycine betaine transport
I653_16380	COG1125	glycine betaine transport
I653_16380	COG0517	IMP dehydrogenase activity
I653_16385	COG1510	regulation of RNA biosynthetic process
I653_16390	COG2095	MarC family integral membrane protein
I653_16400	COG3064	Membrane
I653_16405	COG4640	response to antibiotic
I653_16410	COG0456	acetyltransferase
I653_16425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I653_16445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I653_16450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I653_16460	COG2234	aminopeptidase activity
I653_16465	COG0148	phosphopyruvate hydratase activity
I653_16470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I653_16475	COG0149	triose-phosphate isomerase activity
I653_16480	COG0126	phosphoglycerate kinase activity
I653_16490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I653_16495	COG2390	Transcriptional regulator
I653_16500	COG2814	Major facilitator Superfamily
I653_16505	COG1609	Transcriptional regulator
I653_16510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I653_16515	COG0583	DNA-binding transcription factor activity
I653_16520	COG0697	spore germination
I653_16525	COG1113	amino acid transport
I653_16530	COG3858	chitin binding
I653_16535	COG1556	Lactate utilization protein
I653_16540	COG1139	Iron-sulfur cluster binding protein
I653_16545	COG0247	lactate metabolic process
I653_16550	COG2197	response regulator
I653_16555	COG4585	Histidine kinase
I653_16560	COG0842	Transport permease protein
I653_16565	COG1131	(ABC) transporter
I653_16570	COG0596	Alpha beta hydrolase
I653_16575	COG2208	phosphoserine phosphatase activity
I653_16580	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I653_16585	COG1874	Beta-galactosidase
I653_16590	COG3833	ABC-type maltose transport systems, permease component
I653_16595	COG1175	transmembrane transport
I653_16600	COG2182	Extracellular solute-binding protein
I653_16605	COG1609	Transcriptional regulator
I653_16610	COG2186	Transcriptional regulator
I653_16615	COG1620	l-lactate permease
I653_16620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I653_16630	COG5039	Polysaccharide pyruvyl transferase
I653_16635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I653_16640	COG0110	maltose O-acetyltransferase activity
I653_16645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I653_16650	COG2244	polysaccharide biosynthetic process
I653_16655	COG1216	Glycosyl transferase, family 2
I653_16660	COG5039	Polysaccharide pyruvyl transferase
I653_16665	COG1216	Glycosyl transferase, family 2
I653_16675	COG0438	transferase activity, transferring glycosyl groups
I653_16680	COG1215	transferase activity, transferring glycosyl groups
I653_16685	COG0438	transferase activity, transferring glycosyl groups
I653_16690	COG1086	Polysaccharide biosynthesis protein
I653_16695	COG0489	protein tyrosine kinase activity
I653_16700	COG3944	biosynthesis protein
I653_16705	COG1396	sequence-specific DNA binding
I653_16710	COG2272	Belongs to the type-B carboxylesterase lipase family
I653_16720	COG3479	Phenolic acid decarboxylase
I653_16730	COG1794	racemase activity, acting on amino acids and derivatives
I653_16750	COG1621	beta-fructofuranosidase activity
I653_16755	COG1621	beta-fructofuranosidase activity
I653_16760	COG0531	amino acid
I653_16765	COG1309	transcriptional regulator
I653_16770	COG2076	Multidrug Resistance protein
I653_16775	COG2076	Multidrug Resistance protein
I653_16810	COG0740	serine-type endopeptidase activity
I653_16815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I653_16820	COG0366	Alpha amylase catalytic
I653_16825	COG1554	hydrolase, family 65, central catalytic
I653_16830	COG5521	maltodextrose utilization protein MalA
I653_16835	COG3833	ABC-type maltose transport systems, permease component
I653_16840	COG1175	transmembrane transport
I653_16845	COG2182	Extracellular solute-binding protein
I653_16850	COG0366	Alpha amylase catalytic
I653_16855	COG1609	Transcriptional regulator
I653_16860	COG1611	Belongs to the LOG family
I653_16865	COG1694	Mazg nucleotide pyrophosphohydrolase
I653_16870	COG0659	secondary active sulfate transmembrane transporter activity
I653_16875	COG0288	reversible hydration of carbon dioxide
I653_16880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I653_16885	COG0577	efflux transmembrane transporter activity
I653_16890	COG1136	(ABC) transporter
I653_16895	COG5002	protein histidine kinase activity
I653_16900	COG0745	RESPONSE REGULATOR receiver
I653_16910	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I653_16915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I653_16920	COG1481	regulation of sporulation
I653_16925	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I653_16930	COG1660	Displays ATPase and GTPase activities
I653_16935	COG1051	belongs to the nudix hydrolase family
I653_16940	COG0492	ferredoxin-NADP+ reductase activity
I653_16945	COG0791	NLP P60 protein
I653_16945	COG3883	PFAM NLP P60 protein
I653_16950	COG0457	Tetratricopeptide repeat
I653_16955	COG1132	(ABC) transporter
I653_16975	COG0140	phosphoribosyl-ATP diphosphatase activity
I653_16975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I653_16980	COG0107	imidazoleglycerol-phosphate synthase activity
I653_16985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I653_16990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I653_16995	COG0131	Imidazoleglycerol-phosphate dehydratase
I653_17000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I653_17005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I653_17010	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I653_17015	COG4990	cell redox homeostasis
I653_17020	COG5297	Belongs to the glycosyl hydrolase family 6
I653_17025	COG0110	maltose O-acetyltransferase activity
I653_17030	COG0546	phosphoglycolate phosphatase activity
I653_17035	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I653_17050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I653_17055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I653_17060	COG0363	glucosamine-6-phosphate deaminase activity
I653_17070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I653_17075	COG1950	PFAM Membrane protein of
I653_17080	COG1983	PspC domain protein
I653_17085	COG3595	metallopeptidase activity
I653_17100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I653_17110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I653_17115	COG0556	nucleotide-excision repair
I653_17120	COG4897	Protein conserved in bacteria
I653_17125	COG3848	Pyruvate phosphate dikinase
I653_17125	COG0574	Belongs to the PEP-utilizing enzyme family
I653_17130	COG1309	transcriptional regulator
I653_17135	COG2814	Major facilitator Superfamily
I653_17140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I653_17150	COG0793	Belongs to the peptidase S41A family
I653_17150	COG3409	Peptidoglycan-binding domain 1 protein
I653_17155	COG2177	Part of the ABC transporter FtsEX involved in
I653_17160	COG2884	Cell division ATP-binding protein ftsE
I653_17165	COG2010	Cytochrome c
I653_17170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I653_17175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I653_17180	COG0653	protein targeting
I653_17185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I653_17200	COG1516	flagellar protein fliS
I653_17205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I653_17210	COG1334	flagellar protein FlaG
I653_17215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I653_17220	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I653_17225	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I653_17235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I653_17240	COG4786	Flagellar basal body rod
I653_17240	COG1256	bacterial-type flagellum assembly
I653_17245	COG3418	PFAM FlgN family protein
I653_17250	COG2747	anti-sigma28 factor FlgM
I653_17260	COG1040	competence protein
I653_17270	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I653_17275	COG1307	EDD domain protein, DegV family
I653_17280	COG2197	response regulator
I653_17285	COG4585	Histidine kinase
I653_17290	COG1739	Uncharacterized protein family UPF0029
I653_17295	COG1316	TRANSCRIPTIONal
I653_17300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I653_17305	COG0438	transferase activity, transferring glycosyl groups
I653_17310	COG1215	transferase activity, transferring glycosyl groups
I653_17315	COG3206	protein involved in exopolysaccharide biosynthesis
I653_17320	COG3307	-O-antigen
I653_17325	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I653_17330	COG0297	glycogen (starch) synthase activity
I653_17330	COG0438	transferase activity, transferring glycosyl groups
I653_17335	COG2244	polysaccharide biosynthetic process
I653_17350	COG0860	N-Acetylmuramoyl-L-alanine amidase
I653_17350	COG2247	cell wall binding repeat
I653_17355	COG2247	cell wall binding repeat
I653_17355	COG2385	sporulation resulting in formation of a cellular spore
I653_17365	COG1316	TRANSCRIPTIONal
I653_17370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I653_17390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I653_17395	COG1134	teichoic acid transport
I653_17400	COG1682	transport, permease protein
I653_17420	COG0463	Glycosyl transferase, family 2
I653_17465	COG4193	domain, Protein
I653_17470	COG1482	cell wall glycoprotein biosynthetic process
I653_17475	COG0697	spore germination
I653_17480	COG0814	amino acid
I653_17490	COG2814	Major facilitator Superfamily
I653_17495	COG1316	TRANSCRIPTIONal
I653_17500	COG0561	phosphatase activity
I653_17505	COG0791	NLP P60 protein
I653_17515	COG2843	Capsule synthesis protein
I653_17525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I653_17530	COG1609	Transcriptional regulator
I653_17535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I653_17540	COG1869	D-ribose catabolic process
I653_17545	COG1129	ABC transporter
I653_17550	COG1172	Belongs to the binding-protein-dependent transport system permease family
I653_17555	COG1879	ABC-type sugar transport system periplasmic component
I653_17560	COG3103	Sh3 type 3 domain protein
I653_17570	COG2249	NAD(P)H dehydrogenase (quinone) activity
I653_17575	COG3527	Alpha-acetolactate decarboxylase
I653_17580	COG0028	Belongs to the TPP enzyme family
I653_17585	COG0583	DNA-binding transcription factor activity
I653_17590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I653_17605	COG5337	Spore coat protein CotH
I653_17615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I653_17625	COG0405	Gamma-glutamyltransferase
I653_17630	COG1522	sequence-specific DNA binding
I653_17635	COG2059	Chromate
I653_17640	COG2059	Chromate
I653_17675	COG3878	Protein conserved in bacteria
I653_17680	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I653_17685	COG4464	protein tyrosine phosphatase activity
I653_17690	COG0489	protein tyrosine kinase activity
I653_17695	COG3944	biosynthesis protein
I653_17705	COG4715	Zinc finger, swim domain protein
I653_17710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I653_17715	COG0561	phosphatase activity
I653_17720	COG1349	DNA-binding transcription factor activity
I653_17725	COG0629	single-stranded DNA binding
I653_17740	COG3764	Sortase (surface protein transpeptidase)
I653_17750	COG3279	Response regulator of the LytR AlgR family
I653_17755	COG2972	Histidine kinase
I653_17755	COG0745	RESPONSE REGULATOR receiver
I653_17760	COG1970	mechanosensitive ion channel activity
I653_17765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I653_17770	COG0457	Tetratricopeptide repeat
I653_17775	COG4786	Flagellar basal body rod
I653_17780	COG4786	Flagellar basal body rod
I653_17785	COG1077	Cell shape determining protein MreB Mrl
I653_17790	COG1609	Transcriptional regulator
I653_17795	COG1846	Transcriptional regulator
I653_17800	COG2814	Major facilitator Superfamily
I653_17805	COG3420	alginic acid biosynthetic process
I653_17810	COG1953	Uracil, thiamine, allantoin
I653_17815	COG0477	Major facilitator Superfamily
I653_17820	COG1335	isochorismatase
I653_17830	COG0004	ammonium transporteR
I653_17835	COG0347	Belongs to the P(II) protein family
I653_17840	COG0671	phosphoesterase, PA-phosphatase related
I653_17850	COG0739	heme binding
I653_17855	COG1247	-acetyltransferase
I653_17870	COG2089	acid synthase
I653_17880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I653_17885	COG0789	Transcriptional regulator
I653_17895	COG2910	NAD(P)H-binding
I653_17900	COG1959	2 iron, 2 sulfur cluster binding
I653_17905	COG0804	urea catabolic process
I653_17910	COG0832	Belongs to the urease beta subunit family
I653_17915	COG0831	urea catabolic process
I653_17930	COG3237	CsbD-like
I653_17935	COG1994	Peptidase M50
I653_17940	COG0457	Tetratricopeptide repeat
I653_17945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I653_17950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I653_17960	COG2304	oxidoreductase activity
I653_17970	COG2304	oxidoreductase activity
I653_17975	COG2385	sporulation resulting in formation of a cellular spore
I653_17980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I653_17990	COG4836	Membrane
I653_18000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I653_18005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I653_18010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I653_18015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I653_18020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I653_18025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I653_18030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I653_18035	COG0356	it plays a direct role in the translocation of protons across the membrane
I653_18045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I653_18050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I653_18055	COG4475	Protein of unknown function (DUF436)
I653_18060	COG0698	ribose 5-phosphate isomerase
I653_18065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I653_18070	COG1971	Probably functions as a manganese efflux pump
I653_18075	COG0009	L-threonylcarbamoyladenylate synthase
I653_18080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I653_18100	COG2890	protein-(glutamine-N5) methyltransferase activity
I653_18105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I653_18110	COG0346	lactoylglutathione lyase activity
I653_18115	COG0789	Transcriptional regulator
I653_18120	COG0679	Auxin Efflux Carrier
I653_18125	COG0281	malic enzyme
I653_18130	COG1435	thymidine kinase activity
I653_18135	COG0254	rRNA binding
I653_18140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I653_18145	COG1494	fructose-1,6-bisphosphatase
I653_18150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I653_18160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I653_18165	COG0191	fructose-bisphosphate aldolase activity
I653_18170	COG2204	response regulator
I653_18175	COG4821	SIS domain
I653_18180	COG0504	CTP synthase activity
I653_18185	COG3343	RNA polymerase activity
I653_18190	COG1960	acyl-CoA dehydrogenase activity
I653_18195	COG0247	lactate metabolic process
I653_18195	COG2181	nitrate reductase activity
I653_18200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I653_18205	COG4294	response to UV
I653_18215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I653_18220	COG1132	(ABC) transporter
I653_18225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I653_18230	COG2181	nitrate reductase activity
I653_18235	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I653_18240	COG1140	nitrate reductase beta subunit
I653_18245	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I653_18250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I653_18260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I653_18265	COG2223	nitrite transmembrane transporter activity
I653_18270	COG0018	arginyl-trna synthetase
I653_18275	COG4506	Protein conserved in bacteria
I653_18285	COG0535	radical SAM domain protein
I653_18295	COG1131	(ABC) transporter
I653_18300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I653_18305	COG0612	Peptidase, M16
I653_18310	COG0612	Peptidase, M16
I653_18320	COG3391	amine dehydrogenase activity
I653_18325	COG3391	amine dehydrogenase activity
I653_18335	COG0457	Tetratricopeptide repeat
I653_18365	COG1131	(ABC) transporter
I653_18375	COG0010	Belongs to the arginase family
I653_18380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I653_18385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I653_18395	COG1994	Peptidase M50
I653_18400	COG1942	4-Oxalocrotonate Tautomerase
I653_18405	COG1846	Transcriptional regulator
I653_18410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I653_18425	COG0477	Major facilitator Superfamily
I653_18430	COG1959	2 iron, 2 sulfur cluster binding
I653_18435	COG3465	dGTPase activity
I653_18440	COG1078	dGTPase activity
I653_18445	COG4844	belongs to the
I653_18455	COG0697	spore germination
I653_18465	COG0095	Lipoate-protein ligase
I653_18470	COG0583	DNA-binding transcription factor activity
I653_18475	COG0280	phosphate acetyltransferase
I653_18485	COG1028	Short-chain dehydrogenase reductase Sdr
I653_18490	COG0436	Aminotransferase
I653_18495	COG2814	Major facilitator Superfamily
I653_18500	COG0151	Belongs to the GarS family
I653_18505	COG1028	Short-chain dehydrogenase reductase Sdr
I653_18510	COG1917	Cupin 2, conserved barrel domain protein
I653_18515	COG0077	Prephenate dehydratase
I653_18520	COG2814	Major facilitator Superfamily
I653_18525	COG0833	amino acid
I653_18530	COG4187	Peptidase family M20/M25/M40
I653_18535	COG1012	belongs to the aldehyde dehydrogenase family
I653_18540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I653_18550	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I653_18555	COG1091	dTDP-4-dehydrorhamnose reductase activity
I653_18560	COG1088	dTDP-glucose 4,6-dehydratase activity
I653_18565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I653_18570	COG3980	spore coat polysaccharide biosynthesis protein
I653_18575	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I653_18580	COG2089	acid synthase
I653_18585	COG0456	acetyltransferase
I653_18590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I653_18595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I653_18600	COG0463	Glycosyl transferase, family 2
I653_18610	COG2363	Small membrane protein
I653_18615	COG2233	PERMEase
I653_18625	COG1012	belongs to the aldehyde dehydrogenase family
I653_18630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I653_18635	COG1216	Glycosyl transferase, family 2
I653_18640	COG0351	phosphomethylpyrimidine kinase
I653_18650	COG1621	beta-fructofuranosidase activity
I653_18655	COG1263	PTS System
I653_18655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_18660	COG2116	formate transmembrane transporter activity
I653_18665	COG2116	formate transmembrane transporter activity
I653_18670	COG3711	transcriptional antiterminator
I653_18680	COG1404	Belongs to the peptidase S8 family
I653_18685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I653_18690	COG0778	Nitroreductase
I653_18695	COG0772	Belongs to the SEDS family
I653_18705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I653_18710	COG1845	cytochrome c oxidase, subunit III
I653_18715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I653_18720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I653_18725	COG2261	transglycosylase associated protein
I653_18730	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I653_18735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I653_18740	COG2246	polysaccharide biosynthetic process
I653_18745	COG1309	transcriptional regulator
I653_18755	COG3162	membrane
I653_18760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I653_18765	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I653_18770	COG2837	iron assimilation
I653_18775	COG2822	iron ion transport
I653_18780	COG0672	)-iron permease
I653_18785	COG0352	thiamine-phosphate diphosphorylase activity
I653_18790	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I653_18795	COG0583	DNA-binding transcription factor activity
I653_18800	COG1380	Effector of murein hydrolase LrgA
I653_18805	COG1346	cytolysis
I653_18810	COG2814	Major facilitator Superfamily
I653_18815	COG4895	conserved protein (DUF2196)
I653_18820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I653_18825	COG0346	lactoylglutathione lyase activity
I653_18840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I653_18845	COG1404	Belongs to the peptidase S8 family
I653_18850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_18850	COG1263	PTS System
I653_18855	COG3711	transcriptional antiterminator
I653_18860	COG1442	glycosyl transferase family 8
I653_18865	COG5522	Integral membrane protein (intg_mem_TP0381)
I653_18870	COG1846	Transcriptional regulator
I653_18875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I653_18880	COG2234	aminopeptidase activity
I653_18885	COG2357	RelA SpoT domain protein
I653_18890	COG1575	Belongs to the MenA family. Type 1 subfamily
I653_18900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I653_18905	COG1696	Membrane protein involved in D-alanine export
I653_18910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I653_18915	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I653_18920	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I653_18925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I653_18930	COG1486	melibiose metabolic process
I653_18935	COG1447	Phosphotransferase system cellobiose-specific component IIA
I653_18940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I653_18945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I653_18950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I653_18950	COG3711	transcriptional antiterminator
I653_18960	COG2094	Belongs to the DNA glycosylase MPG family
I653_18965	COG0753	catalase activity
I653_18970	COG2814	Major facilitator Superfamily
I653_18975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I653_18980	COG1131	(ABC) transporter
I653_19000	COG1595	DNA-templated transcription, initiation
I653_19005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I653_19010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I653_19015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I653_19020	COG4988	ABC transporter
I653_19025	COG1294	oxidase, subunit
I653_19030	COG1271	oxidase subunit
I653_19035	COG3493	citrate carrier protein
I653_19040	COG0501	Belongs to the peptidase M48B family
I653_19045	COG0726	polysaccharide deacetylase
I653_19050	COG3842	ATPase activity
I653_19055	COG2508	Transcriptional regulator
I653_19060	COG1012	belongs to the aldehyde dehydrogenase family
I653_19065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I653_19075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I653_19080	COG1881	PFAM PEBP family protein
I653_19085	COG0583	DNA-binding transcription factor activity
I653_19095	COG4585	Histidine kinase
I653_19100	COG2197	response regulator
I653_19105	COG2195	Cleaves the N-terminal amino acid of tripeptides
I653_19120	COG4894	glucomannan catabolic process
I653_19125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I653_19130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I653_19135	COG1028	Short-chain dehydrogenase reductase Sdr
I653_19140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I653_19145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I653_19150	COG2610	gluconate transmembrane transporter activity
I653_19155	COG0500	methyltransferase
I653_19160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I653_19175	COG0753	catalase activity
I653_19175	COG0693	protein deglycase activity
I653_19180	COG2851	Citrate transporter
I653_19185	COG2273	Hydrolase Family 16
I653_19190	COG3711	transcriptional antiterminator
I653_19200	COG2270	Major facilitator Superfamily
I653_19205	COG0513	Belongs to the DEAD box helicase family
I653_19210	COG2755	lipolytic protein G-D-S-L family
I653_19210	COG3401	FG-GAP repeat protein
I653_19230	COG0697	spore germination
I653_19235	COG0589	response to stress
I653_19240	COG2723	6-phospho-beta-galactosidase activity
I653_19245	COG1263	PTS System
I653_19245	COG2190	(PTS) system
I653_19245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I653_19295	COG5444	nuclease activity
I653_19320	COG0494	nUDIX hydrolase
I653_19325	COG3507	Belongs to the glycosyl hydrolase 43 family
I653_19340	COG2986	histidine ammonia-lyase
I653_19345	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I653_19350	COG1228	amidohydrolase
I653_19355	COG0010	Belongs to the arginase family
I653_19360	COG0833	amino acid
I653_19365	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I653_19370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I653_19375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I653_19380	COG2390	Transcriptional regulator
I653_19390	COG3192	ethanolamine utilization protein
I653_19395	COG2079	MmgE PrpD family protein
I653_19405	COG1126	abc transporter atp-binding protein
I653_19410	COG0765	amino acid transport
I653_19415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I653_19430	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I653_19435	COG0561	phosphatase activity
I653_19465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I653_19470	COG5294	Protein conserved in bacteria
I653_19475	COG0577	efflux transmembrane transporter activity
I653_19480	COG1136	(ABC) transporter
I653_19485	COG2205	protein histidine kinase activity
I653_19490	COG0745	RESPONSE REGULATOR receiver
I653_19495	COG0191	fructose-bisphosphate aldolase activity
I653_19500	COG1082	Xylose isomerase domain protein TIM barrel
I653_19505	COG1082	Xylose isomerase domain protein TIM barrel
I653_19510	COG0673	inositol 2-dehydrogenase activity
I653_19515	COG2814	Major facilitator Superfamily
I653_19520	COG1082	Xylose isomerase domain protein TIM barrel
I653_19525	COG3962	Belongs to the TPP enzyme family
I653_19530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I653_19540	COG1012	belongs to the aldehyde dehydrogenase family
I653_19545	COG1349	DNA-binding transcription factor activity
I653_19550	COG0667	Aldo Keto reductase
I653_19565	COG2814	Major facilitator Superfamily
I653_19570	COG0326	Molecular chaperone. Has ATPase activity
I653_19580	COG1028	Short-chain dehydrogenase reductase Sdr
I653_19585	COG1309	transcriptional regulator
I653_19590	COG1012	belongs to the aldehyde dehydrogenase family
I653_19595	COG1714	RDD family
I653_19600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I653_19610	COG1714	RDD family
I653_19615	COG2311	Membrane
I653_19620	COG1917	Cupin 2, conserved barrel domain protein
I653_19625	COG1309	transcriptional regulator
I653_19630	COG1028	Short-chain dehydrogenase reductase Sdr
I653_19635	COG1846	Transcriptional regulator
I653_19640	COG1380	Effector of murein hydrolase LrgA
I653_19645	COG1346	cytolysis
I653_19650	COG5039	Polysaccharide pyruvyl transferase
I653_19655	COG1929	Belongs to the glycerate kinase type-1 family
I653_19660	COG1802	Transcriptional regulator
I653_19665	COG1070	Carbohydrate kinase
I653_19670	COG2610	gluconate transmembrane transporter activity
I653_19675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I653_19680	COG0450	alkyl hydroperoxide reductase
I653_19685	COG3634	alkyl hydroperoxide reductase activity
I653_19695	COG2723	6-phospho-beta-galactosidase activity
I653_19700	COG2190	(PTS) system
I653_19705	COG2188	Transcriptional regulator
I653_19720	COG1131	(ABC) transporter
I653_19725	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I653_19735	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I653_19750	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I653_19765	COG1063	alcohol dehydrogenase
I653_19785	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I653_19790	COG0456	acetyltransferase
I653_19795	COG0457	Tetratricopeptide repeat
I653_19805	COG0010	Belongs to the arginase family
I653_19810	COG0833	amino acid
I653_19815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I653_19820	COG3829	transcription factor binding
I653_19825	COG5002	protein histidine kinase activity
I653_19830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I653_19835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I653_19840	COG4853	Protein conserved in bacteria
I653_19845	COG4863	YycH protein
I653_19850	COG5002	protein histidine kinase activity
I653_19855	COG0745	RESPONSE REGULATOR receiver
I653_19865	COG0346	lactoylglutathione lyase activity
I653_19870	COG0305	Participates in initiation and elongation during chromosome replication
I653_19890	COG3093	addiction module antidote protein HigA
I653_19895	COG2807	transmembrane transport
I653_19900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I653_19905	COG0359	binds to the 23S rRNA
I653_19910	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I653_19915	COG4241	membrane
I653_19925	COG5577	PFAM Coat F domain
I653_19930	COG1733	regulation of RNA biosynthetic process
I653_19935	COG1227	inorganic diphosphatase activity
I653_19950	COG2271	Major facilitator Superfamily
I653_19955	COG4978	Transcriptional regulator
I653_19955	COG0789	Transcriptional regulator
I653_19965	COG4319	ketosteroid isomerase
I653_19970	COG1357	PFAM Pentapeptide repeats (8 copies)
I653_19975	COG2814	Major facilitator Superfamily
I653_19980	COG0583	DNA-binding transcription factor activity
I653_19985	COG2153	protein acetylation
I653_19995	COG0583	DNA-binding transcription factor activity
I653_20015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I653_20020	COG1846	Transcriptional regulator
I653_20025	COG2153	protein acetylation
I653_20030	COG2364	Membrane
I653_20035	COG0456	acetyltransferase
I653_20040	COG2315	Protein conserved in bacteria
I653_20045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I653_20050	COG1331	Highly conserved protein containing a thioredoxin domain
I653_20055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I653_20060	COG0798	PFAM Bile acid sodium symporter
I653_20065	COG0346	lactoylglutathione lyase activity
I653_20070	COG0640	Transcriptional regulator
I653_20080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I653_20085	COG1331	Highly conserved protein containing a thioredoxin domain
I653_20090	COG1266	CAAX protease self-immunity
I653_20095	COG0477	Major facilitator Superfamily
I653_20095	COG2814	Major facilitator Superfamily
I653_20100	COG0110	maltose O-acetyltransferase activity
I653_20105	COG0346	lactoylglutathione lyase activity
I653_20110	COG1609	Transcriptional regulator
I653_20115	COG0708	Exodeoxyribonuclease III
I653_20120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I653_20125	COG0629	single-stranded DNA binding
I653_20130	COG0360	Binds together with S18 to 16S ribosomal RNA
I653_20135	COG0012	GTP binding
I653_20140	COG0243	molybdopterin cofactor binding
I653_20145	COG4481	Protein conserved in bacteria
I653_20150	COG3949	Membrane
I653_20160	COG1475	DNA binding
I653_20165	COG1192	Involved in chromosome partitioning
I653_20175	COG1475	DNA binding
I653_20180	COG0357	Ribosomal RNA small subunit methyltransferase G
I653_20185	COG0445	tRNA wobble uridine modification
I653_20190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I653_20195	COG1847	R3H domain protein
I653_20200	COG0706	membrane insertase activity
I653_20205	COG0594	ribonuclease P activity
I653_20210	COG0230	Belongs to the bacterial ribosomal protein bL34 family