locus-tag class description A7A1_0000 ENOG4108TYN CAAX amino terminal protease family protein A7A1_0001 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) A7A1_0002 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A7A1_0004 ENOG4105PGZ NB-ARC domain A7A1_0005 ENOG4105CPQ Dehydrogenase A7A1_0006 ENOG4105CT4 transporter A7A1_0008 ENOG41087YS Phage shock protein A A7A1_0009 ENOG4105DQX Zinc finger domain A7A1_0010 ENOG4108WV1 Pfam:DUF477 A7A1_0012 ENOG4108ZMR Ion transport 2 domain-containing protein A7A1_0013 ENOG4107QNK )-transporter A7A1_0018 ENOG4107YUH hydrolase A7A1_0020 ENOG4107STQ Multicopper oxidase A7A1_0021 ENOG4105C85 amino acid A7A1_0023 ENOG41068SY A7A1_0026 ENOG4107KNS A7A1_0030 ENOG4108PSK reductase A7A1_0033 ENOG4105DM4 PTS System A7A1_0034 ENOG4105DG6 mannose-6-phosphate isomerase A7A1_0035 ENOG4105G7B Protein of unknown function (DUF2992) A7A1_0036 ENOG4105VMI -acetyltransferase A7A1_0037 ENOG4108Z66 YbaK ebsC protein A7A1_0039 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) A7A1_0041 ENOG4108ZJ4 polysaccharide deacetylase A7A1_0042 ENOG4107CUJ Protein of unknown function (DUF2690) A7A1_0047 ENOG4108IEG Formate dehydrogenase Alpha subunit A7A1_0049 ENOG4108NMV polysaccharide deacetylase A7A1_0052 ENOG4105D1F ATP-binding protein A7A1_0055 ENOG4108I0C methyltransferase A7A1_0056 ENOG4108UJD 30S ribosomal protein S9 A7A1_0057 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) A7A1_0058 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A7A1_0059 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) A7A1_0060 ENOG4108JJB ABC transporter A7A1_0061 ENOG4108JJB ABC transporter A7A1_0062 ENOG4108ZT0 50S ribosomal protein l17 A7A1_0063 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A7A1_0064 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) A7A1_0065 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits A7A1_0067 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) A7A1_0068 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A7A1_0070 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A7A1_0071 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) A7A1_0072 ENOG4105VPB 50S ribosomal protein L30 A7A1_0073 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) A7A1_0074 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) A7A1_0075 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) A7A1_0076 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) A7A1_0078 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits A7A1_0080 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) A7A1_0081 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal A7A1_0082 ENOG41082SA 50s ribosomal protein l29 A7A1_0083 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) A7A1_0084 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) A7A1_0085 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) A7A1_0086 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) A7A1_0087 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity A7A1_0088 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) A7A1_0089 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) A7A1_0090 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) A7A1_0091 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) A7A1_0092 ENOG4107SKW Inherit from COG: Alpha beta hydrolase A7A1_0093 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) A7A1_0094 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) A7A1_0095 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) A7A1_0096 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) A7A1_0097 ENOG4105XPM ribosomal protein A7A1_0098 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A7A1_0099 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A7A1_0100 ENOG4107Y49 methyltransferase A7A1_0101 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) A7A1_0102 ENOG4108VZM 50s ribosomal protein L10 A7A1_0104 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) A7A1_0105 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A7A1_0109 ENOG4105M0M Tetracycline resistance protein A7A1_0110 ENOG4105C2N RNA methyltransferase TrmH family group 3 A7A1_0111 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) A7A1_0112 ENOG4105C8N cysteinyl-tRNA synthetase A7A1_0113 ENOG4105D7W serine acetyltransferase A7A1_0114 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A7A1_0115 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) A7A1_0116 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) A7A1_0117 ENOG4105CTP PilT protein domain protein A7A1_0118 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) A7A1_0119 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) A7A1_0121 ENOG41066A3 ATP guanido phosphotransferase A7A1_0122 ENOG4108Z0C Uvrb UvrC protein A7A1_0124 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A7A1_0125 ENOG4105BZU Histidine kinase A7A1_0128 ENOG4105Q2H domain protein A7A1_0129 ENOG4105C0H protease A7A1_0133 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A7A1_0134 ENOG4105BZU Histidine kinase A7A1_0135 ENOG4105C8Y Acetylornithine aminotransferase A7A1_0136 ENOG4108IQI permease A7A1_0137 ENOG41066UZ arginase EC 3.5.3.1 A7A1_0139 ENOG4105E5J UV damage endonuclease A7A1_0141 ENOG4105NAE bifunctional deaminase-reductase domain protein A7A1_0142 ENOG4105BZ1 (ABC) transporter A7A1_0143 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A7A1_0145 ENOG4105R3A Nitrate reductase A7A1_0146 ENOG4108IUE nitrate reductase beta subunit A7A1_0150 ENOG4107V6Q Cyclic nucleotide-binding domain A7A1_0152 ENOG4105C75 arginyL-tRNA synthetase A7A1_0153 ENOG410684U Domain of unknown function (DUF1934) A7A1_0156 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E A7A1_0165 ENOG4107JM4 Tetratricopeptide repeat A7A1_0167 ENOG4108UIN ybak prolyl-trna synthetase associated region A7A1_0168 ENOG4105CYW agmatinase A7A1_0169 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) A7A1_0170 ENOG4105BZ4 penicillin-binding protein A7A1_0171 ENOG4108XFG YwhD family A7A1_0172 ENOG4108Z4T Peptidase M50 A7A1_0173 ENOG41069HH 4-oxalocrotonate tautomerase A7A1_0174 ENOG41067TZ transcriptional regulator, MarR family A7A1_0175 ENOG4105C22 threonyL-tRNA synthetase A7A1_0176 ENOG4105C57 major facilitator superfamily A7A1_0177 ENOG41062ES Transcriptional regulator A7A1_0179 ENOG4105DCI Phosphohydrolase A7A1_0181 ENOG4108VCI transcription factor, rsfa family A7A1_0182 ENOG4108RNG Permease of the drug metabolite transporter A7A1_0183 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) A7A1_0184 ENOG4105DUM transcriptional regulator, lysR family A7A1_0185 ENOG4108IJ2 phosphate acetyltransferase A7A1_0188 ENOG4105CHM Aminotransferase A7A1_0190 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase A7A1_0191 ENOG4105CHR reductase A7A1_0192 ENOG4106CHD Bacilysin biosynthesis protein bacB A7A1_0193 ENOG41061WN bacilysin biosynthesis protein A7A1_0194 ENOG4105FCW Major Facilitator superfamily A7A1_0197 ENOG4105C26 Dehydrogenase A7A1_0198 ENOG4105D82 Glutamate dehydrogenase A7A1_0200 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase A7A1_0201 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase A7A1_0202 ENOG4105C1B dTDP-glucose 4-6-dehydratase A7A1_0203 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) A7A1_0204 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG A7A1_0205 ENOG4107TY6 Acylneuraminate cytidylyltransferase A7A1_0207 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD A7A1_0208 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A7A1_0215 ENOG4105C26 Dehydrogenase A7A1_0216 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) A7A1_0217 ENOG4108RJ9 Glycosyl transferase, family 2 A7A1_0221 ENOG4105DWF phosphomethylpyrimidine kinase A7A1_0224 ENOG4105C5Y PTS System A7A1_0225 ENOG4108QTI )-transporter A7A1_0230 ENOG4106A3M Cytochrome p-450 A7A1_0231 ENOG41087PP glycosyltransferase MGT family A7A1_0232 ENOG4105EXQ uroporphyrinogen iii synthase hem4 A7A1_0233 ENOG4105C4B ABC transporter, permease A7A1_0234 ENOG4108IXI (ABC) transporter A7A1_0236 ENOG4105Q95 Cupin 2, conserved barrel domain protein A7A1_0239 ENOG4105D2H Uronic isomerase A7A1_0240 ENOG4105CT4 transporter A7A1_0241 ENOG4105DG4 malate L-lactate dehydrogenase A7A1_0242 ENOG4105CPQ Dehydrogenase A7A1_0243 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) A7A1_0244 ENOG4105DMW Dehydrogenase reductase A7A1_0245 ENOG4108I5G Major Facilitator superfamily A7A1_0246 ENOG4107KJX Transcriptional regulator A7A1_0247 ENOG4107QZW Altronate oxidoreductase A7A1_0248 ENOG4105CTX dehydratase A7A1_0249 ENOG4107TSN permease A7A1_0251 ENOG4105JD4 ATPase yjob A7A1_0254 ENOG41068K0 YCII-related domain A7A1_0255 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase A7A1_0256 ENOG4105KWG Pfam:DUF1696 A7A1_0257 ENOG4105K7W phage-related replication protein A7A1_0258 ENOG4105WEF catalase A7A1_0259 ENOG410635T phage-like element pbsx protein A7A1_0266 ENOG4108TFU terminase (Small subunit) A7A1_0267 ENOG4105IG6 Phage terminase, large subunit A7A1_0268 ENOG4108MDF Phage Portal Protein A7A1_0273 ENOG41060SN A7A1_0275 ENOG4105PQS phage protein A7A1_0276 ENOG4105FR7 XkdM protein, phage-like element PBSX A7A1_0277 ENOG4105MTC XkdN-like protein A7A1_0279 ENOG4108MES Periplasmic binding protein A7A1_0280 ENOG4105DQ5 transport system permease protein A7A1_0281 ENOG4108IHU transport system permease protein A7A1_0282 ENOG4105JAB phenazine biosynthesis protein, phzf family A7A1_0283 ENOG4107Y03 Nitroreductase A7A1_0286 ENOG4105ECP epimerase A7A1_0289 ENOG4105F27 Major Facilitator A7A1_0293 ENOG4106AKJ A7A1_0294 ENOG4105D74 hydrolase A7A1_0295 ENOG4105CKK Glycosyl transferase, family 2 A7A1_0296 ENOG4105EJV Membrane A7A1_0297 ENOG41067AE Membrane-bound metal-dependent hydrolase A7A1_0298 ENOG4105CEN a g-specific adenine glycosylase A7A1_0299 ENOG4106BXE A7A1_0300 ENOG4105CAN Short-chain dehydrogenase reductase Sdr A7A1_0303 ENOG4105EVI UPF0374 protein A7A1_0304 ENOG4105BZ1 (ABC) transporter A7A1_0305 ENOG4107NBY Membrane A7A1_0307 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A7A1_0308 ENOG4105G5W regulator Fur family A7A1_0312 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation A7A1_0314 ENOG4105EYH Exonuclease A7A1_0324 ENOG4105ERH Fumarylacetoacetate hydrolase A7A1_0326 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin A7A1_0328 ENOG4105C7F AcnD-accessory protein PrpF A7A1_0329 ENOG41083Q9 chitosanase A7A1_0330 ENOG4105X5K response regulator receiver protein A7A1_0332 ENOG4108VQT Alpha beta hydrolase fold protein A7A1_0333 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein A7A1_0334 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein A7A1_0335 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase A7A1_0337 ENOG4105PGS Spore coat protein A7A1_0338 ENOG4105E2A Dehydrogenase A7A1_0341 ENOG4105VUF Transcriptional regulator A7A1_0342 ENOG4105DQ4 alcohol dehydrogenase A7A1_0343 ENOG4108Z0Z intracellular protease Pfpi family A7A1_0344 ENOG4108HKT sucrose-6-phosphate hydrolase A7A1_0345 ENOG4105F3R pts system mannose fructose sorbose family iid A7A1_0346 ENOG4105ETZ PTS System A7A1_0347 ENOG4108IQ3 PTS system A7A1_0348 ENOG4105YHU PTS system A7A1_0349 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A7A1_0350 ENOG4105C85 amino acid A7A1_0351 ENOG4105N14 lysine exporter protein LysE YggA A7A1_0352 ENOG4108NGU Transcriptional regulator A7A1_0353 ENOG4105JVQ RNA Polymerase A7A1_0354 ENOG4108P49 AntiSigma factor A7A1_0355 ENOG4105EXC Acyl-transferase A7A1_0356 ENOG4105WDR A7A1_0357 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A7A1_0358 ENOG41082JN Transcriptional regulator A7A1_0362 ENOG4105TMB Formate nitrite transporter A7A1_0363 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) A7A1_0364 ENOG4108JB9 formate dehydrogenase A7A1_0367 ENOG4105C28 cystathionine A7A1_0370 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) A7A1_0373 ENOG4107XRG penicillin-binding protein A7A1_0374 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) A7A1_0375 ENOG4105DBI uridine monophosphokinase A7A1_0376 ENOG4105CFP Peptidase U32 A7A1_0377 ENOG4105XYU peptidase (U32 family) A7A1_0378 ENOG4108VQJ O-methyltransferase A7A1_0379 ENOG4105HHA aminodeoxychorismate lyase A7A1_0380 ENOG4105VPH UPF0473 protein A7A1_0381 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) A7A1_0382 ENOG4105VBH UPF0297 protein A7A1_0383 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A7A1_0384 ENOG4105C02 permease A7A1_0385 ENOG4105CDA abc transporter atp-binding protein A7A1_0386 ENOG4105CT1 (ABC) transporter A7A1_0387 ENOG4105EAD ABC transporter A7A1_0388 ENOG4105DRP amino acid AbC transporter A7A1_0390 ENOG4105C7H Helicase, RecD TraA family A7A1_0392 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) A7A1_0393 ENOG4105C3J Cysteine desulfurase A7A1_0395 ENOG4105D1H recombination factor protein RarA A7A1_0396 ENOG4105CUZ uba thif-type nad fad binding protein A7A1_0397 ENOG4105C9M aspartyl-trna synthetase A7A1_0398 ENOG4105CUT histidyl-tRNA synthetase A7A1_0400 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A7A1_0402 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A7A1_0403 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) A7A1_0404 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A7A1_0405 ENOG41067VP Protein of unknown function (DUF1049) A7A1_0406 ENOG4105NCW Trka-c domain protein A7A1_0407 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A7A1_0409 ENOG4105CKP Polysaccharide Biosynthesis Protein A7A1_0410 ENOG4108QG2 Membrane A7A1_0411 ENOG4105NAP A7A1_0412 ENOG4105VIE preprotein translocase, subunit YajC A7A1_0413 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) A7A1_0414 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) A7A1_0415 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) A7A1_0416 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) A7A1_0418 ENOG4105IE8 Alpha-ketoglutarate permease A7A1_0419 ENOG4105CK5 oxidoreductase A7A1_0422 ENOG4105BZG amino acid carrier protein A7A1_0423 ENOG4105CDY transcriptional regulatory protein A7A1_0425 ENOG4106678 morphogenetic protein associated with SpoVID A7A1_0426 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) A7A1_0427 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase A7A1_0428 ENOG4108IYU L-aspartate oxidase A7A1_0431 ENOG4105CQC Prephenate dehydratase A7A1_0432 ENOG41090I5 UPF0735 ACT domain-containing protein A7A1_0433 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control A7A1_0435 ENOG4105K46 50S ribosomal protein l27 A7A1_0436 ENOG4105X36 (ribosomal) protein A7A1_0437 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) A7A1_0440 ENOG4107QMS site-determining protein A7A1_0441 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) A7A1_0442 ENOG4105YHC Rod shape-determining protein MreD A7A1_0443 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) A7A1_0444 ENOG4105DFF Rod shape-determining protein mreb A7A1_0445 ENOG4105W5Q DNA repair protein (RadC A7A1_0446 ENOG4108Z03 MAF-like protein A7A1_0448 ENOG4106A3R peptidase A7A1_0449 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A7A1_0450 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) A7A1_0452 ENOG4106AR7 Spore coat protein A7A1_0453 ENOG41068KH stage VI sporulation protein D A7A1_0454 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase A7A1_0455 ENOG4105D52 delta-aminolevulinic acid dehydratase A7A1_0457 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) A7A1_0459 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) A7A1_0461 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) A7A1_0462 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A7A1_0463 ENOG4108IUQ atp-dependent protease A7A1_0464 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) A7A1_0465 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation A7A1_0467 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A7A1_0468 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A7A1_0469 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) A7A1_0470 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) A7A1_0471 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) A7A1_0472 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) A7A1_0473 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain A7A1_0474 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain A7A1_0476 ENOG4105CXT aspartate transcarbamylase A7A1_0478 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) A7A1_0479 ENOG4105C34 Pseudouridine synthase A7A1_0480 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) A7A1_0482 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A7A1_0484 ENOG4105DBK s4 domain protein A7A1_0485 ENOG41067XK integral membrane protein A7A1_0486 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) A7A1_0487 ENOG4105DFA alanine racemase domain protein A7A1_0488 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase A7A1_0489 ENOG4105WR5 sporulation protein, YlmC YmxH family A7A1_0491 ENOG4105DKW ABC transporter A7A1_0493 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A7A1_0494 ENOG4105FFI sigma-e processing peptidase spoiiga A7A1_0496 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) A7A1_0497 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) A7A1_0498 ENOG4105K67 small basic protein A7A1_0500 ENOG4108R2U division initiation protein A7A1_0501 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) A7A1_0502 ENOG4105D4A Cell wall formation (By similarity) A7A1_0503 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A7A1_0504 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A7A1_0505 ENOG4105CNI cell division protein FtsW A7A1_0506 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) A7A1_0507 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) A7A1_0508 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A7A1_0509 ENOG4105CJN penicillin-binding protein A7A1_0510 ENOG4105CJN penicillin-binding protein A7A1_0512 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) A7A1_0513 ENOG4108V6E Cell division protein mraZ A7A1_0518 ENOG41067VY 50S ribosomal protein L32 A7A1_0519 ENOG4105KNH Nucleic acid-binding protein A7A1_0520 ENOG4105CDE UPF0348 protein A7A1_0521 ENOG41063PX domain protein A7A1_0522 ENOG4105D78 K07001 NTE family protein A7A1_0523 ENOG4105H20 Sporulation integral membrane protein YlbJ A7A1_0524 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) A7A1_0525 ENOG4106H78 methyltransferase A7A1_0526 ENOG4105WUC UPF0298 protein A7A1_0530 ENOG4106UY4 Inherit from COG: Scp-like extracellular A7A1_0531 ENOG41080XQ Signal transduction protein with cbs domains A7A1_0534 ENOG41064X9 cytochrome C oxidase subunit IV A7A1_0535 ENOG4105CCU oxidase (Subunit III) A7A1_0536 ENOG4105BZ9 Cytochrome C oxidase, subunit I A7A1_0538 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) A7A1_0540 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) A7A1_0541 ENOG4105CNI cell division protein FtsW A7A1_0543 ENOG4105ZPI UPF0358 protein A7A1_0544 ENOG4105CSV Glutaminase A7A1_0546 ENOG4108IAB Phoh family A7A1_0549 ENOG4105QA2 A7A1_0550 ENOG4105CI3 gtp-binding protein typa A7A1_0558 ENOG4105JQZ Methyltransferase A7A1_0560 ENOG4105ECY inositol monophosphatase A7A1_0563 ENOG4105WBI UPF0223 protein A7A1_0564 ENOG4105CXN decarboxylase A7A1_0566 ENOG4107QN2 dihydrolipoyl dehydrogenase A7A1_0567 ENOG4105C7S Dehydrogenase A7A1_0568 ENOG4105CPP Dehydrogenase, E1 component A7A1_0572 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A7A1_0573 ENOG4108X4Q Hydrolase A7A1_0575 ENOG4105CN5 Metallo-Beta-Lactamase A7A1_0577 ENOG4107ZYR domain protein A7A1_0579 ENOG4105BZU Histidine kinase A7A1_0583 ENOG410834F Transcriptional regulator A7A1_0584 ENOG4105C0R drug resistance transporter emrb qaca subfamily A7A1_0585 ENOG4108YYS metal-dependent hydrolase (By similarity) A7A1_0586 ENOG4105H93 Acyltransferase family A7A1_0587 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold A7A1_0588 ENOG4105U3E Transcriptional regulator A7A1_0589 ENOG4108KYE ABC-2 type transporter A7A1_0590 ENOG41090VJ ABC-2 type transporter A7A1_0591 ENOG4105CJ1 ABC, transporter A7A1_0592 ENOG4105WH1 Two component transcriptional regulator luxr family A7A1_0593 ENOG4105BZU Histidine kinase A7A1_0594 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A7A1_0596 ENOG4105BZ1 (ABC) transporter A7A1_0597 ENOG4105BZ1 (ABC) transporter A7A1_0598 ENOG4105CI1 PTS System A7A1_0599 ENOG4108Q3X Transcriptional regulator A7A1_0600 ENOG4105F8D glycoside hydrolase family 4 A7A1_0605 ENOG4105KK4 UPF0060 membrane protein A7A1_0606 ENOG41069DP small acid-soluble spore protein A7A1_0607 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family A7A1_0609 ENOG4107QKR Dehydrogenase A7A1_0611 ENOG4107RUY (E1 component), alpha subunit A7A1_0616 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A7A1_0618 ENOG4105D7N magnesium and cobalt transport protein CorA A7A1_0619 ENOG4106KE4 Dehydrogenase A7A1_0623 ENOG4105D8X mechanosensitive ion channel A7A1_0625 ENOG4105UPD Calcium Proton A7A1_0626 ENOG4108ISG Major Facilitator A7A1_0627 ENOG4107U9T Pfam:Ribonuclease_BN A7A1_0629 ENOG4105KJF protein tyrosine phosphatase A7A1_0632 ENOG4107RKG DJ-1/PfpI family A7A1_0633 ENOG4105CGH 5'-nucleotidase A7A1_0634 ENOG4108RCM Nitroreductase A7A1_0635 ENOG4107414 GntR family transcriptional regulator A7A1_0636 ENOG4105CG3 alpha amylase, catalytic region A7A1_0637 ENOG4105C5Y PTS System A7A1_0638 ENOG4105GEU Spore germination protein A7A1_0644 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) A7A1_0648 ENOG4108RPX mosc domain containing protein A7A1_0649 ENOG410855V Acylphosphatase A7A1_0654 ENOG4108MRH transcriptional regulatory protein A7A1_0656 ENOG4107QPK )-transporter A7A1_0657 ENOG4108J20 pectate lyase A7A1_0664 ENOG4108Q8B Spore germination protein A7A1_0665 ENOG4108NHD germination protein A7A1_0668 ENOG4105FVX A7A1_0670 ENOG4105K7W phage-related replication protein A7A1_0672 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) A7A1_0673 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A7A1_0675 ENOG4108SVB resolvase A7A1_0676 ENOG4105CV1 Transketolase (EC 2.2.1.1) A7A1_0681 ENOG4107QIV Cytochrome c biogenesis protein A7A1_0686 ENOG4107DZX Small, acid-soluble spore protein P A7A1_0688 ENOG4108I0Z Aconitate hydratase A7A1_0689 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A7A1_0691 ENOG41067CD Small, acid-soluble spore protein Tlp A7A1_0693 ENOG4105MI2 A7A1_0694 ENOG4105W8X HesB YadR YfhF-family protein A7A1_0695 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A7A1_0696 ENOG4105K4P CoA-binding domain protein A7A1_0697 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A7A1_0701 ENOG4107QWR cellulase (EC 3.2.1.4) A7A1_0703 ENOG4108MYR Secreted protein A7A1_0704 ENOG4107SYN Glycosyl hydrolases family 43 A7A1_0706 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A7A1_0707 ENOG4107T5V SNARE associated Golgi A7A1_0709 ENOG4107QX3 carboxylase A7A1_0710 ENOG4105E39 Enoyl-CoA hydratase A7A1_0711 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase A7A1_0712 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A7A1_0713 ENOG4105CEY Amp-dependent synthetase and ligase A7A1_0714 ENOG4105C1G acyl-Coa dehydrogenase A7A1_0716 ENOG4105F32 YngK protein A7A1_0717 ENOG4106U2H Protein of unknown function (DUF1360) A7A1_0724 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A7A1_0725 ENOG4105EFZ amidohydrolase A7A1_0726 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A7A1_0727 ENOG4105D07 Signal peptide peptidase, SppA A7A1_0728 ENOG4105VK3 rdd domain containing protein A7A1_0730 ENOG4105KBJ sporulation protein ytfj A7A1_0731 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) A7A1_0733 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) A7A1_0734 ENOG4105EPU Molybdenum cofactor synthesis domain protein A7A1_0735 ENOG4105CDH Citrulline--aspartate ligase A7A1_0736 ENOG4105CH7 arginosuccinase A7A1_0739 ENOG4105E8R UPF0173 metal-dependent hydrolase A7A1_0740 ENOG4108KSA LysR family transcriptional regulator A7A1_0741 ENOG4108XSB acetyltransferase, (GNAT) family A7A1_0746 ENOG4105CDA abc transporter atp-binding protein A7A1_0747 ENOG4105DEN Luciferase family A7A1_0751 ENOG4105CH2 amidohydrolase A7A1_0752 ENOG410635A Membrane A7A1_0755 ENOG4105SFS phosphoesterase RecJ domain protein A7A1_0757 ENOG4105VV2 A7A1_0758 ENOG4105C0B DNA polymerase III (alpha subunit) A7A1_0759 ENOG4105C0B DNA polymerase III (alpha subunit) A7A1_0760 ENOG4108IEY Carboxyl transferase domain A7A1_0762 ENOG4105CTQ phosphohexokinase A7A1_0763 ENOG4105CA9 Pyruvate kinase A7A1_0764 ENOG4105FS0 cytoplasmic membrane protein A7A1_0765 ENOG4108REF Sporulation integral membrane protein ytvi A7A1_0767 ENOG4105BZN citrate synthase A7A1_0768 ENOG4108HMX isocitrate dehydrogenase (NADP) A7A1_0769 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A7A1_0770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A7A1_0771 ENOG4105BZU Histidine kinase A7A1_0772 ENOG4105C2M dna polymerase I A7A1_0773 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A7A1_0775 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A7A1_0776 ENOG4105CV8 reductase A7A1_0777 ENOG4105F27 Major Facilitator A7A1_0778 ENOG4105KVH Transcriptional regulator A7A1_0779 ENOG4108KAM Transcriptional regulator A7A1_0781 ENOG4105CPC Aldo Keto reductase A7A1_0782 ENOG410904A RNA polymerase A7A1_0783 ENOG4108MEK Metal-binding protein YodA A7A1_0785 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A7A1_0786 ENOG4105EA8 2-Nitropropane dioxygenase A7A1_0787 ENOG41075D4 Aminoglycoside 6-adenylyltransferase A7A1_0790 ENOG41064BW Protein of unknown function (DUF2568) A7A1_0794 ENOG41067XF inhibitor A7A1_0795 ENOG4108ZRZ Transcriptional regulator (AsnC family) A7A1_0796 ENOG4108UMN azlc family A7A1_0797 ENOG4105KMT branched-chain amino acid A7A1_0801 ENOG41090U3 tautomerase A7A1_0802 ENOG4105PGM cation diffusion facilitator family transporter A7A1_0803 ENOG4105H3G oxidoreductase A7A1_0804 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family A7A1_0806 ENOG4105C37 (CBS) domain A7A1_0809 ENOG41090E6 transcriptional regulator MERR family A7A1_0811 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein A7A1_0814 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase A7A1_0815 ENOG4105VFE sira family A7A1_0817 ENOG4107TPS domain protein A7A1_0818 ENOG4105VFE sira family A7A1_0819 ENOG41087NI Sulfite exporter TauE/SafE A7A1_0820 ENOG41068VA A7A1_0821 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein A7A1_0823 ENOG4108UYN gCN5-related N-acetyltransferase A7A1_0825 ENOG4105DHF Membrane A7A1_0826 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A7A1_0827 ENOG4108SWU Histidine kinase A7A1_0828 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A7A1_0830 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A7A1_0839 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase A7A1_0841 ENOG4108IG5 Transcriptional regulator A7A1_0843 ENOG4106ANW SMI1_KNR4 A7A1_0844 ENOG4106BHF A7A1_0850 ENOG4107Y5K Resolvase A7A1_0851 ENOG4105C0R drug resistance transporter emrb qaca subfamily A7A1_0853 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A7A1_0854 ENOG4105WFK nuclease A7A1_0857 ENOG41080BT SNARE associated Golgi A7A1_0858 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A7A1_0861 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase A7A1_0862 ENOG4105CQW ribosome biogenesis GTPase YqeH A7A1_0863 ENOG4105E2X shikimate dehydrogenase A7A1_0864 ENOG410812S Rna-binding protein A7A1_0865 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) A7A1_0866 ENOG4108WF2 Metal Dependent Phosphohydrolase A7A1_0868 ENOG4108D32 Methyltransferase A7A1_0870 ENOG4105KQC Competence protein A7A1_0871 ENOG4108UK2 deaminase A7A1_0872 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 A7A1_0873 ENOG4105TQK DNA polymerase iii, delta' subunit A7A1_0874 ENOG41082YS Binds directly to 16S ribosomal RNA A7A1_0875 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) A7A1_0879 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) A7A1_0880 ENOG4108UGV hypoxanthine phosphoribosyltransferase A7A1_0881 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A7A1_0883 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) A7A1_0884 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase A7A1_0885 ENOG4105C6T cysteine synthase A7A1_0886 ENOG4105CRQ synthase (Component I) A7A1_0887 ENOG4105DDQ anthranilate synthase A7A1_0888 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 A7A1_0889 ENOG4105EEI dihydropteroate synthase A7A1_0890 ENOG4105KRF dihydroneopterin aldolase A7A1_0891 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase A7A1_0893 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A7A1_0894 ENOG4105CRK lysyL-tRNA synthetase A7A1_0895 ENOG4105CAQ asparagine synthetase A7A1_0898 ENOG4105UQX Mate efflux family protein A7A1_0899 ENOG4106HBX Transcriptional Regulator AraC Family A7A1_0900 ENOG4105ETE Transcriptional regulator (LacI family A7A1_0901 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) A7A1_0902 ENOG4105SF0 DinB family A7A1_0903 ENOG4108ZUB Lysine exporter protein (Lyse ygga) A7A1_0904 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A7A1_0905 ENOG4105MYW Pentapeptide repeat protein A7A1_0906 ENOG4107S9D Alpha beta hydrolase A7A1_0907 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) A7A1_0908 ENOG4107RIQ Sulfate adenylate transferase A7A1_0909 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) A7A1_0910 ENOG4108N5B 2-phosphosulfolactate phosphatase A7A1_0911 ENOG41061P3 phosphosulfolactate synthase A7A1_0913 ENOG4105DIA mandelate racemase muconate lactonizing A7A1_0914 ENOG4107RCC Major Facilitator Superfamily A7A1_0915 ENOG4108SZE gCN5-related N-acetyltransferase A7A1_0916 ENOG4105MA6 gCN5-related N-acetyltransferase A7A1_0918 ENOG4108VPT UPF0234 protein A7A1_0919 ENOG4105QNR S1 RNA binding domain protein A7A1_0923 ENOG4105K7K Transcriptional regulator A7A1_0925 ENOG410751J A7A1_0926 ENOG4105D4Y metalloprotease A7A1_0927 ENOG4105EPR degv family A7A1_0928 ENOG4107AYK membrAne A7A1_0930 ENOG4108KP7 hydrolase A7A1_0931 ENOG4108MXZ Esterase A7A1_0932 ENOG4105VG1 fes assembly suf system protein A7A1_0933 ENOG4105IQ5 FAD linked oxidase domain protein A7A1_0935 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase A7A1_0939 ENOG4105C8Y Acetylornithine aminotransferase A7A1_0940 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain A7A1_0942 ENOG4105DBV ornithine carbamoyltransferase A7A1_0947 ENOG4107RMD Basic membrane lipoprotein A7A1_0950 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A7A1_0951 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A7A1_0953 ENOG4105C3U ABC transporter A7A1_0954 ENOG4108JQ7 (ABC) transporter A7A1_0957 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A7A1_0959 ENOG4105C31 Tryptophanyl-tRNA synthetase A7A1_0960 ENOG4108J59 Extracellular solute-binding protein, family 5 A7A1_0961 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A7A1_0962 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A7A1_0964 ENOG4108JQ7 (ABC) transporter A7A1_0967 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) A7A1_0968 ENOG4108ZCF integral membrane protein A7A1_0969 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis A7A1_0971 ENOG4105DPN Oligoendopeptidase f A7A1_0972 ENOG4105T58 Dithiol-disulfide isomerase A7A1_0973 ENOG4108Z18 K06886 hemoglobin A7A1_0974 ENOG4105E4C Lytic transglycosylase catalytic A7A1_0975 ENOG4105MIX Adenylate cyclase A7A1_0978 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A7A1_0979 ENOG4105EMS pseudouridine synthase A7A1_0982 ENOG4105ETU transcriptional activator (TenA A7A1_0983 ENOG4108VEU Thiamine monophosphate synthase A7A1_0986 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) A7A1_0987 ENOG4105D06 uba thif-type nad fad binding protein A7A1_0988 ENOG4105DWF phosphomethylpyrimidine kinase A7A1_0989 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH A7A1_0990 ENOG4107A88 A7A1_1000 ENOG4105ENA helicase A7A1_1003 ENOG4108ZMI UPF0477 protein A7A1_1007 ENOG4107TT2 Auxin Efflux Carrier A7A1_1009 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase A7A1_1010 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A7A1_1011 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A7A1_1014 ENOG4108ZXQ stage ii sporulation protein r A7A1_1016 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A7A1_1017 ENOG410815N Probably functions as a manganese efflux pump (By similarity) A7A1_1018 ENOG4107WAU Protein tyrosine phosphatase A7A1_1019 ENOG4108YZG isomerase A7A1_1020 ENOG4108UIC UPF0340 protein A7A1_1021 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) A7A1_1022 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) A7A1_1024 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) A7A1_1028 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) A7A1_1029 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) A7A1_1030 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) A7A1_1031 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) A7A1_1033 ENOG4106778 Protein of unknown function (DUF1146) A7A1_1035 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A7A1_1036 ENOG4105JFG SpoIID LytB domain protein A7A1_1039 ENOG4108TF4 von Willebrand factor, type A A7A1_1041 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A7A1_1047 ENOG4108YZ9 Urea amidohydrolase subunit gamma A7A1_1048 ENOG4105KI2 Urea amidohydrolase subunit beta A7A1_1049 ENOG4105CQM Urea amidohydrolase subunit alpha A7A1_1050 ENOG4108Z40 Transcriptional regulator A7A1_1051 ENOG4108RYK Nad-dependent epimerase dehydratase A7A1_1052 ENOG4106BRK A7A1_1053 ENOG4107TXC Transcriptional regulator A7A1_1054 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A7A1_1057 ENOG4107TCE N-acetyltransferase A7A1_1058 ENOG4105FRN stage II sporulation protein A7A1_1062 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase A7A1_1064 ENOG4105BZU Histidine kinase A7A1_1065 ENOG4107P26 A7A1_1066 ENOG4105D3W isochorismatase A7A1_1067 ENOG41080V3 Major Facilitator superfamily A7A1_1068 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease A7A1_1069 ENOG4108M26 parallel beta-helix repeat protein A7A1_1070 ENOG4105CZM Major Facilitator A7A1_1071 ENOG4107MII Sugar-specific transcriptional regulator TrmB A7A1_1073 ENOG4105MT0 Sporulation transcriptional regulator spoiiid A7A1_1074 ENOG4105DFF Rod shape-determining protein mreb A7A1_1076 ENOG4105CGA flagellar basal-body rod protein FlgG A7A1_1078 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) A7A1_1079 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) A7A1_1081 ENOG4108VAC response regulator A7A1_1087 ENOG4105Z8H single-stranded DNA-binding protein A7A1_1088 ENOG4105E98 transcriptional regulator DeoR family A7A1_1089 ENOG410667J hydrolase A7A1_1090 ENOG4105C0D helicase A7A1_1091 ENOG4105KBK Zinc finger, swim domain protein A7A1_1092 ENOG4105HTX biosynthesis protein A7A1_1093 ENOG4107YJ4 chain length determinant protein A7A1_1094 ENOG4108RB3 Capsular polysaccharide biosynthesis protein A7A1_1095 ENOG4105C6Y Udp-glucose 6-dehydrogenase A7A1_1096 ENOG4108XI2 Domain of unknown function (DUF1963) A7A1_1100 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) A7A1_1101 ENOG4107V2S Transcriptional regulator A7A1_1102 ENOG4108WS4 fmn reductase A7A1_1104 ENOG4105FGV Chromate A7A1_1105 ENOG4105CAH Chromate A7A1_1107 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A7A1_1109 ENOG4107XC4 flavin reductase domain protein, FMN-binding A7A1_1112 ENOG4106UIA A7A1_1115 ENOG4107RSM transcriptional regulator A7A1_1117 ENOG4107FQX Alpha-acetolactate decarboxylase A7A1_1118 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein A7A1_1121 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A7A1_1122 ENOG4105CNN ABC, transporter A7A1_1123 ENOG4105C2J ABC transporter A7A1_1124 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) A7A1_1125 ENOG4108RVA ribokinase A7A1_1126 ENOG4105ETE Transcriptional regulator (LacI family A7A1_1127 ENOG4105N98 Capsule biosynthesis protein capB A7A1_1129 ENOG4105PNM synthesis protein A7A1_1131 ENOG4105K4H Nlp p60 protein A7A1_1132 ENOG4105J7I hydrolase A7A1_1133 ENOG4108KGH TRANSCRIPTIONal A7A1_1134 ENOG4105C54 Major Facilitator superfamily A7A1_1135 ENOG4108NHD germination protein A7A1_1138 ENOG4105DG6 mannose-6-phosphate isomerase A7A1_1148 ENOG41088M2 Glycosyl transferase family 2 A7A1_1149 ENOG4107VDP teichoic acid biosynthesis A7A1_1150 ENOG4107VDP teichoic acid biosynthesis A7A1_1151 ENOG4107VDP teichoic acid biosynthesis A7A1_1153 ENOG4105EY8 ABC transporter A7A1_1154 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A7A1_1159 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase A7A1_1162 ENOG4105JFG SpoIID LytB domain protein A7A1_1163 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A7A1_1165 ENOG4105D3Q Sugar transferase A7A1_1166 ENOG4105PSV Polysaccharide Biosynthesis Protein A7A1_1167 ENOG4107RA4 Glycosyl transferase (Group 1 A7A1_1168 ENOG4105C6Y Udp-glucose 6-dehydrogenase A7A1_1169 ENOG4105QZI O-Antigen Polymerase A7A1_1172 ENOG4107EF8 Glycosyl transferase (Group 1 A7A1_1173 ENOG4105ESV Glycosyl transferase, family 4 A7A1_1174 ENOG4108KGH TRANSCRIPTIONal A7A1_1175 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein A7A1_1176 ENOG4105BZU Histidine kinase A7A1_1177 ENOG4105WH1 Two component transcriptional regulator luxr family A7A1_1181 ENOG41081UC Inherit from COG: Competence protein A7A1_1182 ENOG4105RU3 A7A1_1185 ENOG4105E1Q flagellar hook-associated protein A7A1_1186 ENOG4105DTJ flagellar hook-associated protein A7A1_1187 ENOG4105MKD A7A1_1188 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) A7A1_1189 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) A7A1_1190 ENOG4105I03 Flagellin A7A1_1191 ENOG41083S7 flagellar protein FlaG A7A1_1192 ENOG4107RT6 flagellar hook-associated A7A1_1193 ENOG4105MQ3 flagellar protein FliS A7A1_1196 ENOG4105MS2 ribosomal subunit Interface protein A7A1_1198 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) A7A1_1201 ENOG4105CAK Cell division ATP-binding protein ftsE A7A1_1202 ENOG4105CRP Part of the ABC transporter FtsEX involved in A7A1_1203 ENOG4105CN1 protease A7A1_1207 ENOG4105MKU Transcriptional regulator A7A1_1209 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) A7A1_1210 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A7A1_1214 ENOG4108PY7 A7A1_1215 ENOG41067S9 phage shock protein C, PspC A7A1_1216 ENOG41086DT Membrane protein of unknown function A7A1_1219 ENOG410625E A7A1_1221 ENOG4105C0W non-ribosomal peptide synthetase A7A1_1222 ENOG4105C0W non-ribosomal peptide synthetase A7A1_1224 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) A7A1_1226 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) A7A1_1227 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) A7A1_1228 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) A7A1_1229 ENOG4105ZMH deoxynucleoside kinase A7A1_1231 ENOG4105VRS hydrolase family 18 A7A1_1232 ENOG4105GTG Isochorismatase A7A1_1233 ENOG4108Z6B deaminase A7A1_1234 ENOG4105C6E dna polymerase iii A7A1_1235 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) A7A1_1236 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) A7A1_1238 ENOG41067KS pro-sigma K processing A7A1_1239 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A7A1_1240 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase A7A1_1241 ENOG4105CDU Replicative dna helicase A7A1_1245 ENOG4105DJ2 Major Facilitator Superfamily A7A1_1246 ENOG4105EDW glycosyl transferase, family 39 A7A1_1247 ENOG4105K9Q Binds to the 23S rRNA (By similarity) A7A1_1248 ENOG4105BZR domain protein A7A1_1249 ENOG4108XMW Membrane A7A1_1251 ENOG4105KVH Transcriptional regulator A7A1_1252 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase A7A1_1256 ENOG41090E6 transcriptional regulator MERR family A7A1_1258 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein A7A1_1259 ENOG4105DDN Pentapeptide repeat-containing protein A7A1_1260 ENOG4105D94 Major Facilitator Superfamily A7A1_1261 ENOG4107RSM transcriptional regulator A7A1_1262 ENOG41082BV acetyltransferase A7A1_1263 ENOG4108J8C transporter major facilitator family protein A7A1_1267 ENOG4108IPJ Membrane A7A1_1268 ENOG4105C7Z Conserved Protein A7A1_1269 ENOG4107FCW Abortive infection protein A7A1_1271 ENOG4108UW5 maltose o-acetyltransferase A7A1_1272 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase A7A1_1274 ENOG4105CGK Exodeoxyribonuclease III A7A1_1275 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) A7A1_1276 ENOG4108UUM single-stranded DNA-binding protein A7A1_1277 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) A7A1_1278 ENOG4105C3G gtp-binding protein A7A1_1279 ENOG4105FA0 parb-like partition protein A7A1_1280 ENOG4107QJE Chromosome Partitioning Protein A7A1_1283 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) A7A1_1284 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) A7A1_1285 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) A7A1_1288 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) A7A1_1290 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) A7A1_1291 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A7A1_1292 ENOG410848D S4 domain protein YaaA A7A1_1295 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A7A1_1296 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A7A1_1297 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A7A1_1298 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A7A1_1307 ENOG4105VZ8 Transcriptional regulator A7A1_1310 ENOG4108V4B ThiJ pfpI A7A1_1311 ENOG4105VEQ Cold shock protein A7A1_1312 ENOG4108VJ1 Transcriptional regulator (CarD family A7A1_1314 ENOG4108MCI Transcriptional regulator, ARAC family A7A1_1315 ENOG4108UZ3 Transporter A7A1_1316 ENOG41086D8 Transcriptional regulator A7A1_1317 ENOG4107U9B transcriptional regulator A7A1_1318 ENOG4105DXI Major Facilitator superfamily A7A1_1320 ENOG4105CZ9 Domain of unknown function (DU1801) A7A1_1321 ENOG4105GIG A7A1_1323 ENOG4105KRI phosphocarrier protein (HPr A7A1_1324 ENOG4105ST3 Transcriptional regulator A7A1_1325 ENOG4105T38 integral membrane protein A7A1_1326 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A7A1_1327 ENOG4108ZMQ domain protein A7A1_1328 ENOG4105MJ9 esterase A7A1_1329 ENOG4107Z6X Transcriptional regulator A7A1_1331 ENOG4105KVH Transcriptional regulator A7A1_1332 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein A7A1_1333 ENOG4105EQ0 Major Facilitator superfamily A7A1_1334 ENOG4108JGH Tetr family transcriptional regulator A7A1_1335 ENOG41082YX Transcriptional regulator, arsr family A7A1_1336 ENOG4107R5R arsenical pump membrane protein A7A1_1337 ENOG4105Z7P Acetyltransferase (GNAT) family A7A1_1338 ENOG4107Y9U Membrane A7A1_1340 ENOG4108SQ9 flavin reductase domain protein, FMN-binding A7A1_1341 ENOG4108ZHR arsR family transcriptional regulator A7A1_1342 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) A7A1_1343 ENOG4105ENE Histidine kinase A7A1_1344 ENOG4108VB1 regulatoR A7A1_1345 ENOG4105EYF MMPL domain protein A7A1_1346 ENOG4108WC5 Alpha Beta Hydrolase Fold protein A7A1_1347 ENOG4108UQV Membrane A7A1_1348 ENOG4108Z5V transcriptional regulator, merr family A7A1_1349 ENOG41076HS cation diffusion facilitator family transporter A7A1_1350 ENOG4108TVJ Nitroreductase A7A1_1351 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase A7A1_1352 ENOG4108VGI doxx family A7A1_1353 ENOG4105XXY Thioredoxin A7A1_1356 ENOG410900G Protein of unknown function (DUF421) A7A1_1357 ENOG4108QY0 Membrane A7A1_1361 ENOG4105PF9 Transcriptional regulator A7A1_1363 ENOG4105WQG acetyltransferase A7A1_1365 ENOG4105C85 amino acid A7A1_1367 ENOG41062A4 Transcriptional regulator A7A1_1368 ENOG4105EYF MMPL domain protein A7A1_1369 ENOG4105EYF MMPL domain protein A7A1_1370 ENOG4108TVJ Nitroreductase A7A1_1371 ENOG4105FS7 Transcriptional regulator A7A1_1372 ENOG4105C2C drug resistance transporter, Bcr CflA A7A1_1374 ENOG4105DRR Transcriptional regulator, GntR family A7A1_1375 ENOG4105VRS hydrolase family 18 A7A1_1378 ENOG4105G6Z alkaline phosphatase A7A1_1379 ENOG4108ZMX Domain of unknown function (DU1801) A7A1_1381 ENOG4108YM7 Gcn5-related n-acetyltransferase A7A1_1382 ENOG4107TVP HD domain protein A7A1_1383 ENOG41090UD (LipO)protein A7A1_1384 ENOG4105F27 Major Facilitator A7A1_1385 ENOG4105VZJ PTS System A7A1_1386 ENOG4105VCP PTS System A7A1_1387 ENOG4105CK1 PTS System A7A1_1388 ENOG4105CS2 ec 3.2.1.21 A7A1_1389 ENOG4108TZY GntR Family Transcriptional Regulator A7A1_1390 ENOG4105EVU fructokinase A7A1_1391 ENOG4105DG6 mannose-6-phosphate isomerase A7A1_1392 ENOG4105D3P Mannan endo-1,4-beta-mannosidase A7A1_1395 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) A7A1_1396 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein A7A1_1397 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A7A1_1399 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) A7A1_1400 ENOG4107MMM Anti-sigma-factor antagonist A7A1_1401 ENOG4105FUA antagonist A7A1_1402 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase A7A1_1403 ENOG4107SGM protein serine threonine phosphatase A7A1_1404 ENOG4105WN5 stage II sporulation protein A7A1_1405 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) A7A1_1407 ENOG41064BQ Phosphatase A7A1_1410 ENOG4108FKH Transglycosylase SLT domain A7A1_1411 ENOG4108WZM domain protein A7A1_1412 ENOG4105X7F A7A1_1414 ENOG4105MFU Protein of unknown function (DUF2634) A7A1_1415 ENOG41066EA baseplate J family protein A7A1_1416 ENOG410906S phage-like element pbsx protein xkdt A7A1_1418 ENOG41068G1 A7A1_1424 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A7A1_1427 ENOG4105CJ3 phosphate transporter A7A1_1428 ENOG4107GRR phosphate transport regulator A7A1_1429 ENOG4107R7I amino acid A7A1_1431 ENOG4105EDW glycosyl transferase, family 39 A7A1_1432 ENOG4105CKK Glycosyl transferase, family 2 A7A1_1434 ENOG4105C0H protease A7A1_1436 ENOG4108ME1 Peptidase M55 D-aminopeptidase A7A1_1437 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A7A1_1438 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A7A1_1439 ENOG4105C3U ABC transporter A7A1_1441 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A A7A1_1442 ENOG4105DTQ mandelate racemase muconate lactonizing A7A1_1443 ENOG4107SN7 NLP P60 protein A7A1_1444 ENOG4108JQ7 (ABC) transporter A7A1_1445 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) A7A1_1446 ENOG4107TUM Amidinotransferase A7A1_1447 ENOG4108S4H thioesterase Superfamily protein A7A1_1448 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) A7A1_1452 ENOG4108428 Inherit from COG: -acetyltransferase A7A1_1454 ENOG41080TC multidrug resistance protein A7A1_1455 ENOG4105CIY formyltetrahydrofolate deformylase A7A1_1456 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A7A1_1459 ENOG4105K56 Transcriptional regulator A7A1_1460 ENOG4108ZHJ Organic hydroperoxide resistance protein A7A1_1461 ENOG4107Y2X deaminase A7A1_1462 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) A7A1_1463 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin A7A1_1465 ENOG4108W7F transporter, permease A7A1_1466 ENOG4108JJB ABC transporter A7A1_1467 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein A7A1_1468 ENOG4108X43 YKOF domain protein A7A1_1469 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A7A1_1470 ENOG41062D9 Histidine kinase A7A1_1472 ENOG4106849 propeptide, pepSY amd peptidase M4 A7A1_1474 ENOG4105CJW magnesium transporter A7A1_1475 ENOG4105V75 Transcriptional regulator A7A1_1484 ENOG4105DQE DNA ligase A7A1_1485 ENOG4105FDF Could be involved in DNA repair (By similarity) A7A1_1486 ENOG4105BZU Histidine kinase A7A1_1487 ENOG4107T5V SNARE associated Golgi A7A1_1488 ENOG4107TS3 membrane protein, TerC A7A1_1489 ENOG4108WZW RNA polymerase sigma A7A1_1491 ENOG410681C small acid-soluble spore protein A7A1_1493 ENOG4105D0M Protease HtpX homolog A7A1_1496 ENOG4108TGC Acyltransferase A7A1_1497 ENOG4105BZU Histidine kinase A7A1_1498 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A7A1_1499 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) A7A1_1500 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) A7A1_1501 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A7A1_1503 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit A7A1_1504 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) A7A1_1505 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) A7A1_1506 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) A7A1_1510 ENOG4105BZU Histidine kinase A7A1_1511 ENOG41090MY MarR family Transcriptional regulator A7A1_1512 ENOG4105ER2 Ompa motb domain protein A7A1_1513 ENOG4105E14 MotA TolQ exbB proton channel A7A1_1515 ENOG4108K88 Membrane A7A1_1516 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) A7A1_1517 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase A7A1_1518 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) A7A1_1519 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) A7A1_1521 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr A7A1_1523 ENOG4105FEA Spore maturation protein A7A1_1527 ENOG4105F0V Cell wall hydrolase A7A1_1531 ENOG4105C59 p-type ATPase A7A1_1532 ENOG4105DC7 peptidase M24 A7A1_1534 ENOG4105CID antiterminator A7A1_1536 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) A7A1_1539 ENOG4105F6S Spore photoproduct lyase A7A1_1541 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer A7A1_1542 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A7A1_1543 ENOG4105K4I Scp-like extracellular A7A1_1545 ENOG4105BZU Histidine kinase A7A1_1546 ENOG4105CHM Aminotransferase A7A1_1547 ENOG4107R88 Chemotaxis protein (CheV) A7A1_1548 ENOG4105UIN A7A1_1550 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein A7A1_1552 ENOG4105K6S Short-chain dehydrogenase reductase Sdr A7A1_1553 ENOG4105ESF Peptidoglycan binding domain protein A7A1_1555 ENOG4105EPM Diguanylate phosphodiesterase A7A1_1556 ENOG4107IN1 Protein of unknown function (DUF1797) A7A1_1557 ENOG4105CHH sulfate transporter A7A1_1559 ENOG4108SA1 esterase A7A1_1563 ENOG410874W AraC family transcriptional regulator A7A1_1564 ENOG4105EHZ conserved protein UCP016719 A7A1_1565 ENOG4105D17 glycoside hydrolase, family 3 domain protein A7A1_1569 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate A7A1_1571 ENOG4105EWC Purine nucleoside phosphorylase A7A1_1572 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A7A1_1574 ENOG4105CFH Aspartokinase A7A1_1576 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit A7A1_1578 ENOG4105E33 succinate dehydrogenase A7A1_1580 ENOG4105PFC Transcriptional regulator A7A1_1581 ENOG41067TZ transcriptional regulator, MarR family A7A1_1582 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A7A1_1583 ENOG4108XJQ germination protein A7A1_1584 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) A7A1_1585 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A7A1_1586 ENOG4105M59 Phosphodiesterase, mj0936 family A7A1_1587 ENOG4107KM7 Heat induced stress protein YflT A7A1_1588 ENOG4105I4A GCN5-related N-acetyltransferase A7A1_1590 ENOG4105C7K acetolactate synthase A7A1_1591 ENOG4108ZP8 Acetolactate synthase small subunit A7A1_1592 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A7A1_1593 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) A7A1_1594 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A7A1_1595 ENOG4105CKV Membrane A7A1_1596 ENOG410905X membrane-flanked domain protein A7A1_1597 ENOG4105C1J atp-dependent rna helicase A7A1_1598 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) A7A1_1599 ENOG4105CPF Cell wall formation (By similarity) A7A1_1600 ENOG4105SZ6 Thioredoxin A7A1_1603 ENOG4105FDT acyl-CoA dehydrogenase A7A1_1606 ENOG4105CJ1 ABC, transporter A7A1_1607 ENOG4106F5Q Membrane A7A1_1608 ENOG4107QJT sodium dicarboxylate symporter A7A1_1609 ENOG4108MRH transcriptional regulatory protein A7A1_1610 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism A7A1_1611 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A7A1_1614 ENOG41082W1 Cupin 2, conserved barrel domain protein A7A1_1615 ENOG4105QVS general stress protein A7A1_1616 ENOG4105EU9 A7A1_1617 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) A7A1_1619 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) A7A1_1623 ENOG4105C0X amino acid A7A1_1625 ENOG4107R8N Glycosyl transferase, family 2 A7A1_1626 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) A7A1_1629 ENOG4105C9U ATP-dependent DNA helicase RecQ A7A1_1631 ENOG4105VCH membrane A7A1_1633 ENOG410606W general stress protein A7A1_1636 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A7A1_1637 ENOG4105HMZ Methyltransferase A7A1_1639 ENOG4105ETD TRANSCRIPTIONal A7A1_1640 ENOG4107QM2 Aldo Keto reductase A7A1_1641 ENOG4107RVG penicillin-binding protein A7A1_1642 ENOG4105BZU Histidine kinase A7A1_1644 ENOG4105C8T Leucyl-tRNA synthetase A7A1_1645 ENOG41085GJ domain protein A7A1_1647 ENOG4105I1K ABC transporter A7A1_1648 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component A7A1_1651 ENOG4105NTD Inherit from COG: Hydrolase A7A1_1652 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) A7A1_1653 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A7A1_1654 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A7A1_1656 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) A7A1_1657 ENOG4106A3M Cytochrome p-450 A7A1_1659 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component A7A1_1661 ENOG41075H3 AraC family transcriptional regulator A7A1_1663 ENOG4105F5H Glycosyl Hydrolase Family 88 A7A1_1665 ENOG4105DDC Oxidoreductase domain protein A7A1_1666 ENOG4105MU9 integral membrane protein A7A1_1668 ENOG4105C94 Transporter A7A1_1669 ENOG4105CBX hi0933 family A7A1_1673 ENOG4105YW5 deoR family transcriptional regulator A7A1_1676 ENOG4105C7N Xanthine uracil vitamin C permease A7A1_1677 ENOG4107QSE Dipeptidase A7A1_1678 ENOG4105C6T cysteine synthase A7A1_1679 ENOG4107F58 2'-5' rna ligase A7A1_1682 ENOG4108IUM Glycogen debranching enzyme A7A1_1683 ENOG4108V15 phosphotransferase enzyme family A7A1_1685 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) A7A1_1686 ENOG4105C8F Beta-lactamase domain protein A7A1_1687 ENOG4105C6K Malic enzyme A7A1_1690 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ A7A1_1693 ENOG4108VDD TRNA binding domain protein A7A1_1695 ENOG4105DFU Cell wall formation (By similarity) A7A1_1699 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A7A1_1700 ENOG4105ETE Transcriptional regulator (LacI family A7A1_1701 ENOG4107R0U MotA TolQ exbB proton channel A7A1_1702 ENOG4105ER2 Ompa motb domain protein A7A1_1703 ENOG4105DGU Histone deacetylase A7A1_1705 ENOG4105F1V Acetoin utilization protein A7A1_1706 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A7A1_1707 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) A7A1_1708 ENOG4105BZU Histidine kinase A7A1_1710 ENOG4105U5Y Transcriptional regulator A7A1_1712 ENOG4105C0W non-ribosomal peptide synthetase A7A1_1713 ENOG4105CEY Amp-dependent synthetase and ligase A7A1_1715 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A7A1_1716 ENOG4105CVR type I restriction-modification system A7A1_1718 ENOG4105DZR Type I site-specific deoxyribonuclease A7A1_1728 ENOG4105CDY transcriptional regulatory protein A7A1_1730 ENOG4105M4P Tetr family transcriptional regulator A7A1_1731 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein A7A1_1732 ENOG4107S9F NmrA family A7A1_1735 ENOG4105WEF catalase A7A1_1736 ENOG4105M18 -acetyltransferase A7A1_1739 ENOG4105C2F Histidine kinase A7A1_1740 ENOG4105EQD regulatoR A7A1_1741 ENOG410769Z extracellular solute-binding protein family 1 A7A1_1742 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component A7A1_1743 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component A7A1_1744 ENOG4105F5H Glycosyl Hydrolase Family 88 A7A1_1745 ENOG41075H3 AraC family transcriptional regulator A7A1_1746 ENOG4107TDE lipolytic protein G-D-S-L family A7A1_1749 ENOG4105CX8 fg-gap repeat protein A7A1_1750 ENOG4105CX8 fg-gap repeat protein A7A1_1751 ENOG4107TDE lipolytic protein G-D-S-L family A7A1_1753 ENOG4105EKC A7A1_1754 ENOG4105E0S extracellular solute-binding protein family 1 A7A1_1756 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component A7A1_1757 ENOG4105F8D glycoside hydrolase family 4 A7A1_1758 ENOG4105H67 Protein of unknown function (DUF421) A7A1_1759 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) A7A1_1760 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily A7A1_1764 ENOG4106I4J membrane A7A1_1765 ENOG41082F9 transcriptional regulator A7A1_1766 ENOG41061H0 Monooxygenase A7A1_1767 ENOG4108R1P A7A1_1768 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A7A1_1769 ENOG4105E0M Sulfatase A7A1_1770 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase A7A1_1772 ENOG41090R9 glycosyltransferase A7A1_1773 ENOG4107R51 Glycosyl transferase, family 2 A7A1_1774 ENOG41090R9 glycosyltransferase A7A1_1775 ENOG4105EU0 Major facilitator Superfamily A7A1_1777 ENOG4105CUB amino acid A7A1_1778 ENOG4105C26 Dehydrogenase A7A1_1779 ENOG4105FKZ Methyl-accepting chemotaxis A7A1_1780 ENOG4105C5H ABC transporter A7A1_1782 ENOG4107SWG transcriptional regulator MERR family A7A1_1783 ENOG4105DXB Major Facilitator superfamily A7A1_1785 ENOG4105C5H ABC transporter A7A1_1786 ENOG4105FDU atp-dependent rna helicase A7A1_1788 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein A7A1_1791 ENOG4105E6M Sulphatase-modifying factor protein A7A1_1792 ENOG4105E0A ABC, transporter A7A1_1793 ENOG4108U1V ABC transporter, permease A7A1_1794 ENOG4105DQ5 transport system permease protein A7A1_1795 ENOG4108HUF Transporter A7A1_1800 ENOG4105CDW Resistance protein A7A1_1801 ENOG4105CXN decarboxylase A7A1_1802 ENOG4105CXN decarboxylase A7A1_1803 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) A7A1_1804 ENOG4105X0R protein from nitrogen regulatory protein P-II A7A1_1805 ENOG4105XVJ Protein of unknown function (DUF327) A7A1_1806 ENOG4105FA2 dna polymerase iii A7A1_1807 ENOG4105MA4 psp1 domain protein A7A1_1808 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) A7A1_1809 ENOG41060K3 Methyltransferase A7A1_1810 ENOG4105VC4 domain protein A7A1_1811 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A7A1_1812 ENOG4105KRN Transcriptional regulator, abrb family A7A1_1813 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) A7A1_1814 ENOG4105F8V Hydrolase, tatD family A7A1_1815 ENOG41069ER domain protein A7A1_1817 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A7A1_1818 ENOG4105XFA sporulation peptidase YabG A7A1_1819 ENOG4105W42 Veg protein A7A1_1820 ENOG4105XEW small acid-soluble spore protein A7A1_1821 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) A7A1_1822 ENOG4105DFT pur operon repressor A7A1_1823 ENOG4105KME endoribonuclease L-psp A7A1_1824 ENOG4105K4W Could be involved in septation (By similarity) A7A1_1825 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) A7A1_1826 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A7A1_1828 ENOG4108JA2 transcriptioN-repair coupling factor A7A1_1829 ENOG4108M14 stage v sporulation protein t A7A1_1831 ENOG4108IY2 MazG family A7A1_1832 ENOG41082I2 s4 domain protein A7A1_1833 ENOG4105VYY sporulation protein yabp A7A1_1836 ENOG41060GV RNA binding s1 domain protein A7A1_1837 ENOG4108DBC nitroreductase A7A1_1838 ENOG4105DEN Luciferase family A7A1_1839 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin A7A1_1840 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A7A1_1841 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) A7A1_1842 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) A7A1_1843 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A7A1_1844 ENOG4105C5H ABC transporter A7A1_1845 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A7A1_1846 ENOG410801F ribosomal-protein-alanine acetyltransferase A7A1_1847 ENOG41072GX Peptidase M22 Glycoprotease A7A1_1848 ENOG4105K8N protein family UPF0079, ATPase A7A1_1849 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) A7A1_1850 ENOG4105KVH Transcriptional regulator A7A1_1851 ENOG4108VA3 3-hexulose-6-phosphate synthase A7A1_1852 ENOG41080HJ 6-phospho 3-hexuloisomerase A7A1_1853 ENOG4105C8Q Methyl-accepting chemotaxis A7A1_1856 ENOG4105CS2 ec 3.2.1.21 A7A1_1857 ENOG4108VEN abc transporter atp-binding protein A7A1_1858 ENOG4105K56 Transcriptional regulator A7A1_1860 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein A7A1_1861 ENOG4105E5Q amino acid AbC transporter A7A1_1862 ENOG4105CKI cobalamin synthesis protein A7A1_1863 ENOG4105S7A ErfK ybiS ycfS ynhG family protein A7A1_1867 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) A7A1_1868 ENOG4108IFG nitrite reductase, (NAD(P)H) A7A1_1869 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit A7A1_1870 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A7A1_1872 ENOG4105U6C Alpha beta hydrolase fold protein A7A1_1873 ENOG4108PJD permease A7A1_1875 ENOG4107YHD transcriptional regulator A7A1_1876 ENOG4105CK7 Sodium proline symporter A7A1_1877 ENOG4105C26 Dehydrogenase A7A1_1879 ENOG410756H nucleotidyltransferase A7A1_1880 ENOG4105I82 acetyl xylan esterase A7A1_1881 ENOG4105C5Q Transcriptional regulator A7A1_1882 ENOG41089UC methyltransferase, type 11 A7A1_1883 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) A7A1_1884 ENOG4105I1F Resistance protein A7A1_1885 ENOG4107RA1 nh(3)-dependent nad( ) synthetase A7A1_1887 ENOG4105EIG urea carboxylase-associated protein 1 A7A1_1893 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A7A1_1899 ENOG4107SQ8 Glycine betaine A7A1_1900 ENOG4108IJ7 Glycine betaine A7A1_1901 ENOG4108A65 Transcriptional regulator A7A1_1902 ENOG4107XZQ multidrug resistance protein A7A1_1903 ENOG41079KZ Major Facilitator Superfamily A7A1_1905 ENOG4108TTB tellurium resistance protein A7A1_1906 ENOG4107TS3 membrane protein, TerC A7A1_1907 ENOG4106FN3 tellurium resistance protein A7A1_1908 ENOG4106FN3 tellurium resistance protein A7A1_1909 ENOG4108N0M stress protein A7A1_1910 ENOG4105DEN Luciferase family A7A1_1912 ENOG4105DIK (ABC) transporter A7A1_1913 ENOG4105DSE periplasmic solute binding protein A7A1_1915 ENOG4105H9W Short-chain dehydrogenase reductase Sdr A7A1_1921 ENOG4107SET aldo keto reductase A7A1_1922 ENOG4108SDH ABC, transporter A7A1_1923 ENOG4108IUW ABC transporter A7A1_1924 ENOG4107Y7X LytTR A7A1_1926 ENOG41060AI SEC-C motif A7A1_1928 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold A7A1_1929 ENOG4107RB3 L-asparaginase A7A1_1930 ENOG4105J7D transcriptional regulator A7A1_1931 ENOG4105C0R drug resistance transporter emrb qaca subfamily A7A1_1932 ENOG4107EPV Aminotransferase class V A7A1_1933 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) A7A1_1934 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A7A1_1935 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) A7A1_1936 ENOG4105DGI Alkaline phosphatase A7A1_1938 ENOG4105MUA Resistance protein A7A1_1944 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A7A1_1945 ENOG4106UX7 integral membrane protein A7A1_1949 ENOG4105CTX dehydratase A7A1_1950 ENOG41073TP transcriptional regulator A7A1_1951 ENOG4105EQX glucarate dehydratase A7A1_1952 ENOG4105DJB Major Facilitator Superfamily A7A1_1953 ENOG4105C26 Dehydrogenase A7A1_1954 ENOG4108ITS PQQ enzyme repeat A7A1_1955 ENOG41085PJ rdd domain containing protein A7A1_1956 ENOG4105C26 Dehydrogenase A7A1_1957 ENOG4105ST3 Transcriptional regulator A7A1_1958 ENOG41061TZ Short-chain dehydrogenase reductase Sdr A7A1_1960 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) A7A1_1961 ENOG4107QNK )-transporter A7A1_1964 ENOG4105CPC Aldo Keto reductase A7A1_1966 ENOG4105C26 Dehydrogenase A7A1_1967 ENOG4105DH8 myo-inositol catabolism A7A1_1968 ENOG4105D7K pfkb domain protein A7A1_1969 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) A7A1_1970 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) A7A1_1972 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) A7A1_1973 ENOG4105F0H myo-inositol catabolism protein A7A1_1974 ENOG4107TRN Xylose isomerase domain protein TIM barrel A7A1_1975 ENOG4105D2N Aldolase A7A1_1981 ENOG4108V5C ABC transporter A7A1_1987 ENOG410667J hydrolase A7A1_1988 ENOG4107QHE Choloylglycine hydrolase A7A1_1990 ENOG4105CPU Monooxygenase A7A1_1991 ENOG4108XSB acetyltransferase, (GNAT) family A7A1_1992 ENOG4105EAB amino acid AbC transporter A7A1_1993 ENOG4108HW4 amino acid AbC transporter A7A1_1995 ENOG4105CH2 amidohydrolase A7A1_1996 ENOG4108PGP mmge prpd family protein A7A1_1997 ENOG4105ENY Ethanolamine utilization protein eutH A7A1_1998 ENOG4108TM9 integral membrane protein A7A1_1999 ENOG4107RHR regulatoR A7A1_2001 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) A7A1_2005 ENOG4105C5Y PTS System A7A1_2006 ENOG4105CS2 ec 3.2.1.21 A7A1_2007 ENOG4107YZX Universal stress protein A7A1_2018 ENOG4107TDE lipolytic protein G-D-S-L family A7A1_2019 ENOG4105C1J atp-dependent rna helicase A7A1_2020 ENOG4105DEU major facilitator superfamily A7A1_2022 ENOG4105CID antiterminator A7A1_2023 ENOG4105D4T Citrate transporter A7A1_2024 ENOG4105CH6 catalase A7A1_2028 ENOG4105DHI Methyltransferase A7A1_2029 ENOG4105CY2 Citrate transporter A7A1_2030 ENOG4105D6N CoA-transferase, subunit a A7A1_2031 ENOG4108IIH CoA-transferase subunit B A7A1_2032 ENOG4105DTD Dehydrogenase A7A1_2037 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) A7A1_2038 ENOG4105WH1 Two component transcriptional regulator luxr family A7A1_2039 ENOG4105BZU Histidine kinase A7A1_2041 ENOG4105CMR udp-glucose 4-epimerase A7A1_2043 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) A7A1_2047 ENOG4107BJW polysaccharide deacetylase A7A1_2050 ENOG4105D2K citrate carrier protein A7A1_2051 ENOG4105C4M (Ubiquinol oxidase) subunit I A7A1_2052 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A7A1_2053 ENOG4108JJ9 ABC, transporter A7A1_2054 ENOG4108JJ8 (ABC) transporter A7A1_2055 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) A7A1_2056 ENOG4105ETS cytosine purines uracil thiamine allantoin A7A1_2060 ENOG41069JR A7A1_2061 ENOG4105DA5 (ABC) transporter A7A1_2064 ENOG4105CH6 catalase A7A1_2065 ENOG4108VX5 3-methyladenine DNA glycosylase A7A1_2067 ENOG4105EMD TRANSCRIPTIONal A7A1_2068 ENOG4105VZJ PTS System A7A1_2069 ENOG4105CK1 PTS System A7A1_2070 ENOG4105VCP PTS System A7A1_2071 ENOG4105F8D glycoside hydrolase family 4 A7A1_2072 ENOG4105CM2 brancheD-chain amino acid aminotransferase A7A1_2073 ENOG4108VHC Short-chain dehydrogenase reductase Sdr A7A1_2074 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD A7A1_2076 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A7A1_2077 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) A7A1_2078 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase A7A1_2084 ENOG4105IIU Aminopeptidase A7A1_2085 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A7A1_2086 ENOG4105GVJ transcriptional regulator A7A1_2088 ENOG4105X1N Glycosyl transferase family 8 A7A1_2091 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin A7A1_2092 ENOG4105CK1 PTS System A7A1_2094 ENOG4105DR4 Methyltransferase A7A1_2096 ENOG4105D8G Major Facilitator superfamily A7A1_2097 ENOG41067MG lrgb family A7A1_2098 ENOG4105VAW lrga family A7A1_2099 ENOG4105CMU LysR family (Transcriptional regulator A7A1_2101 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) A7A1_2102 ENOG4107SJW iron permease, FTR1 A7A1_2103 ENOG410650H (LipO)protein A7A1_2104 ENOG4105DBE peroxidase A7A1_2105 ENOG4107ZXU DSBA oxidoreductase A7A1_2110 ENOG4105WH5 Teichoic acid glycosylation protein A7A1_2111 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) A7A1_2114 ENOG4105E2S oxidase) subunit II A7A1_2115 ENOG4105BZ9 Cytochrome C oxidase, subunit I A7A1_2116 ENOG4105CCU oxidase (Subunit III) A7A1_2117 ENOG41060D1 Quinol oxidase A7A1_2120 ENOG4107WD8 ABC transporter, permease A7A1_2124 ENOG4105E1K spore germination protein A7A1_2127 ENOG4105DUX Transporter A7A1_2129 ENOG41069ZX A7A1_2130 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) A7A1_2131 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase A7A1_2132 ENOG4106P55 Transcriptional regulator A7A1_2134 ENOG4105DRP amino acid AbC transporter A7A1_2135 ENOG4105CDA abc transporter atp-binding protein A7A1_2137 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) A7A1_2139 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) A7A1_2142 ENOG4108KS4 Spore coat protein A7A1_2143 ENOG4107SBE Glycosyl transferase (Group 1 A7A1_2146 ENOG4107SBE Glycosyl transferase (Group 1 A7A1_2147 ENOG4108IAJ Nad-dependent epimerase dehydratase A7A1_2151 ENOG4105E4F Isochorismate synthase A7A1_2152 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) A7A1_2153 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) A7A1_2154 ENOG4108IPT Naphthoate synthase A7A1_2155 ENOG4105CEY Amp-dependent synthetase and ligase A7A1_2156 ENOG4105DTQ mandelate racemase muconate lactonizing A7A1_2157 ENOG4105DSE periplasmic solute binding protein A7A1_2158 ENOG4105DIK (ABC) transporter A7A1_2159 ENOG4105CC5 ABC transporter A7A1_2160 ENOG4105CC5 ABC transporter A7A1_2165 ENOG4108V2W Carbonate dehydratase A7A1_2166 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) A7A1_2167 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) A7A1_2169 ENOG4108RMU ferritin dps family protein A7A1_2172 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component A7A1_2174 ENOG4105D2X ABC transporter substrate-binding protein A7A1_2175 ENOG4105D2X ABC transporter substrate-binding protein A7A1_2178 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase A7A1_2179 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP A7A1_2180 ENOG4105CAQ asparagine synthetase A7A1_2181 ENOG4105C85 amino acid A7A1_2182 ENOG4108Z0R Transferase A7A1_2183 ENOG4105E8V Alpha Beta Hydrolase Fold protein A7A1_2186 ENOG4105N5T Radical SAM Protein A7A1_2188 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A7A1_2189 ENOG4105DVE abc transporter atp-binding protein A7A1_2192 ENOG4105C19 ABC transporter A7A1_2193 ENOG4107R34 abc transporter permease protein A7A1_2195 ENOG4105EWM Histidine kinase A7A1_2196 ENOG4105C19 ABC transporter A7A1_2198 ENOG4106UBQ A7A1_2199 ENOG410605W Major Facilitator A7A1_2201 ENOG4105W8Z 4'-phosphopantetheinyl transferase A7A1_2203 ENOG4105SX7 Transporter A7A1_2209 ENOG4105N67 Proton-coupled thiamine transporter YuaJ A7A1_2210 ENOG4105VRR gCN5-related N-acetyltransferase A7A1_2211 ENOG4105DZ6 Band 7 protein A7A1_2213 ENOG4106DF1 A7A1_2214 ENOG4108VNY MOSC domain protein A7A1_2215 ENOG4108JB8 alcohol dehydrogenase A7A1_2216 ENOG4105C26 Dehydrogenase A7A1_2217 ENOG4105TRT Transcriptional regulator A7A1_2220 ENOG4105CZN Potassium uptake protein A7A1_2221 ENOG4107I77 yiaA/B two helix domain A7A1_2222 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj A7A1_2226 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A7A1_2228 ENOG4105EE0 oxidoreductase A7A1_2229 ENOG4105DKG l-rhamnose isomerase A7A1_2230 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) A7A1_2231 ENOG4105DET Rhamnulokinase A7A1_2232 ENOG4105E98 transcriptional regulator DeoR family A7A1_2234 ENOG4105C8Q Methyl-accepting chemotaxis A7A1_2235 ENOG4105C8Q Methyl-accepting chemotaxis A7A1_2236 ENOG4105C8Q Methyl-accepting chemotaxis A7A1_2237 ENOG4105C8Q Methyl-accepting chemotaxis A7A1_2240 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme A7A1_2242 ENOG4105C37 (CBS) domain A7A1_2244 ENOG4107PBV potassium channel A7A1_2247 ENOG4107QYV phosphohexose isomerase A7A1_2249 ENOG4107QW4 alcohol dehydrogenase A7A1_2250 ENOG4105WG9 Conserved Protein A7A1_2252 ENOG4105CHM Aminotransferase A7A1_2253 ENOG4108ZB6 transcriptional regulator AsnC family A7A1_2254 ENOG4108MUZ hydrolase A7A1_2256 ENOG4105C87 Aminotransferase class I and II A7A1_2257 ENOG4108HGU Histidine kinase A7A1_2258 ENOG4105Y38 Kinase-associated protein B A7A1_2261 ENOG4105BZ4 penicillin-binding protein A7A1_2262 ENOG4105KIR Thiol-disulfide oxidoreductase dcc A7A1_2265 ENOG4108MRH transcriptional regulatory protein A7A1_2266 ENOG4105DIH basic membrane A7A1_2267 ENOG4108JQ9 ABC transporter A7A1_2268 ENOG4105UIB (ABC) transporter A7A1_2272 ENOG4105D65 subunit l A7A1_2273 ENOG4105HC0 Na H antiporter A7A1_2274 ENOG4108ZE9 Monovalent cation H antiporter subunit C A7A1_2275 ENOG4108JPZ Monovalent cation H antiporter subunit D A7A1_2276 ENOG4105SC1 monovalent cation H antiporter subunit E A7A1_2278 ENOG4105KJM monovalent cation h antiporter subunit g A7A1_2279 ENOG4105KA0 thioesterase Superfamily protein A7A1_2281 ENOG4105BZU Histidine kinase A7A1_2286 ENOG4105D58 Diguanylate phosphodiesterase A7A1_2287 ENOG4105DAP Nicotinate phosphoribosyltransferase A7A1_2292 ENOG4105C02 permease A7A1_2296 ENOG410904N short-chain dehydrogenase reductase A7A1_2304 ENOG4108K8K Transcriptional regulator A7A1_2305 ENOG4105DCF alanine dehydrogenase A7A1_2308 ENOG4105CEY Amp-dependent synthetase and ligase A7A1_2309 ENOG4105WQI isochorismatase A7A1_2310 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase A7A1_2311 ENOG4105E4F Isochorismate synthase A7A1_2312 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase A7A1_2313 ENOG4105NIV Esterase A7A1_2317 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A7A1_2319 ENOG41069ER domain protein A7A1_2322 ENOG4105CEP NADH dehydrogenase A7A1_2323 ENOG4105CAY ferredoxin--nadp reductase A7A1_2327 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 A7A1_2329 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein A7A1_2330 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) A7A1_2331 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) A7A1_2332 ENOG4105D6E homoserine dehydrogenase A7A1_2334 ENOG4108W5N phosphatidylglycerophosphatase a A7A1_2335 ENOG4105D4U had-superfamily hydrolase, subfamily iia A7A1_2337 ENOG4105MMD transcriptional regulator A7A1_2338 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) A7A1_2339 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) A7A1_2340 ENOG4105FAA peptidase M23 A7A1_2341 ENOG4108YTE sporulation protein YunB A7A1_2342 ENOG4105KZD Domain of unknown function (DUF1805) A7A1_2343 ENOG4107R8B 5'-nucleotidase A7A1_2345 ENOG4105I3N Conserved Protein A7A1_2351 ENOG4105NQC Flavodoxin A7A1_2353 ENOG4105CH2 amidohydrolase A7A1_2355 ENOG4105D8X mechanosensitive ion channel A7A1_2356 ENOG4105D3R alkyl hydroperoxide reductase A7A1_2357 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A7A1_2360 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) A7A1_2361 ENOG4105D06 uba thif-type nad fad binding protein A7A1_2362 ENOG4105CVM Molybdenum cofactor synthesis domain protein A7A1_2363 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein A7A1_2364 ENOG4108ZAF Molybdopterin A7A1_2365 ENOG41067WU Molybdopterin converting factor (Subunit 1) A7A1_2366 ENOG4105BZ1 (ABC) transporter A7A1_2367 ENOG4105BZ1 (ABC) transporter A7A1_2369 ENOG4107X8C Efflux transporter RND family MFP subunit A7A1_2370 ENOG4105C19 ABC transporter A7A1_2371 ENOG4107RBB ABC transporter, permease A7A1_2372 ENOG4105E98 transcriptional regulator DeoR family A7A1_2373 ENOG4105DE4 1-phosphofructokinase A7A1_2374 ENOG4105DM4 PTS System A7A1_2375 ENOG4105C3F Signal peptidase i A7A1_2377 ENOG4105C5H ABC transporter A7A1_2378 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) A7A1_2380 ENOG410780I phosphoprotein phosphatase activity A7A1_2381 ENOG4105WQG acetyltransferase A7A1_2382 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) A7A1_2385 ENOG4105E2A Dehydrogenase A7A1_2388 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) A7A1_2396 ENOG4108JU3 Alkyl hydroperoxide reductase A7A1_2397 ENOG4105C6Z Gluconate A7A1_2398 ENOG4105CMG Carbohydrate kinase A7A1_2399 ENOG4105G3Z GntR family transcriptional regulator A7A1_2400 ENOG4105BZW Glycerate kinase A7A1_2402 ENOG41067MG lrgb family A7A1_2403 ENOG41061AU MarR family Transcriptional regulator A7A1_2404 ENOG4107JEE Short-chain dehydrogenase reductase Sdr A7A1_2405 ENOG4105J7D transcriptional regulator A7A1_2408 ENOG41085PJ rdd domain containing protein A7A1_2410 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A7A1_2416 ENOG4105C7N Xanthine uracil vitamin C permease A7A1_2417 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family A7A1_2418 ENOG4108N2V aldose 1-epimerase A7A1_2419 ENOG4107QJQ Mate efflux family protein A7A1_2423 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A7A1_2424 ENOG4105SKE transcriptional Regulator LysR family A7A1_2425 ENOG4105CB2 alcohol dehydrogenase A7A1_2426 ENOG4105BZ8 glutamate synthase A7A1_2427 ENOG4105CBC glutamate synthase A7A1_2428 ENOG4105C5Q Transcriptional regulator A7A1_2429 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A7A1_2430 ENOG4105II7 pyrroline-5-carboxylate reductase A7A1_2434 ENOG4108UB7 A7A1_2435 ENOG41068WN A7A1_2438 ENOG4105CJ1 ABC, transporter A7A1_2440 ENOG4105IE8 Alpha-ketoglutarate permease A7A1_2441 ENOG4107U6E carbohydrate kinase FGGY A7A1_2442 ENOG4108M3J Dehydrogenase A7A1_2443 ENOG4108J2R molybdopterin oxidoreductase A7A1_2447 ENOG4105EC8 Methyl-accepting chemotaxis A7A1_2449 ENOG4108YQE rare lipoprotein a A7A1_2450 ENOG4105XPP Protein of unknown function (DUF1275) A7A1_2451 ENOG4108NR7 pectate lyase A7A1_2452 ENOG4108RAV Conserved protein A7A1_2454 ENOG4105F0F Oxalate decarboxylase A7A1_2455 ENOG4105CD3 dihydroorotase A7A1_2456 ENOG4105G9B Transcriptional regulator A7A1_2459 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) A7A1_2460 ENOG4105VT2 5-hydroxyisourate hydrolase A7A1_2463 ENOG4107YV9 domain protein A7A1_2464 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding A7A1_2467 ENOG4105XRQ Xanthine dehydrogenase accessory factor A7A1_2468 ENOG4105C5R Aminotransferase A7A1_2470 ENOG4108K8S endonuclease I A7A1_2471 ENOG4108IJ9 (ABC) transporter A7A1_2472 ENOG4105FDP GntR family transcriptional regulator A7A1_2473 ENOG4108KPW sugar kinase A7A1_2474 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component A7A1_2475 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component A7A1_2476 ENOG4105XN3 extracellular solute-binding protein family 1 A7A1_2477 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine A7A1_2478 ENOG4105PKS Excinuclease abc c subunit domain protein A7A1_2479 ENOG4107VFR oxidoreductase A7A1_2482 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase A7A1_2483 ENOG4105NPE arsR family transcriptional regulator A7A1_2484 ENOG4105DIW FeS assembly protein SUFB A7A1_2485 ENOG4108UNV SUF system FeS assembly protein, NifU family A7A1_2486 ENOG4105C9B Cysteine desulfurase A7A1_2487 ENOG4105JRK feS assembly protein SufD A7A1_2488 ENOG4105C3K feS assembly ATPase SufC A7A1_2491 ENOG4105D01 (LipO)protein A7A1_2492 ENOG4108UMI ABC transporter, permease A7A1_2493 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A7A1_2498 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) A7A1_2499 ENOG41080E8 Transcriptional regulator, Spx MgsR family A7A1_2500 ENOG4105C1G acyl-Coa dehydrogenase A7A1_2501 ENOG4105CHU acetyl-coa acetyltransferase A7A1_2506 ENOG41067TZ transcriptional regulator, MarR family A7A1_2507 ENOG4105C0R drug resistance transporter emrb qaca subfamily A7A1_2508 ENOG4105MDS 4-oxalocrotonate tautomerase A7A1_2510 ENOG4105EGI Transcriptional regulator A7A1_2512 ENOG4105E0A ABC, transporter A7A1_2515 ENOG4105E1F short-chain dehydrogenase reductase A7A1_2516 ENOG4105HUF DNA protection during starvation protein A7A1_2517 ENOG4105C0H protease A7A1_2519 ENOG4105F3H Histidine kinase A7A1_2520 ENOG41067SE Tetr family transcriptional regulator A7A1_2521 ENOG4105C9Q fumarate hydratase class II A7A1_2525 ENOG4105WH1 Two component transcriptional regulator luxr family A7A1_2526 ENOG4105ENE Histidine kinase A7A1_2529 ENOG41087YS Phage shock protein A A7A1_2532 ENOG4108WBT adenosyltransferase A7A1_2533 ENOG4105E0A ABC, transporter A7A1_2534 ENOG4105EHG Permease protein A7A1_2535 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) A7A1_2536 ENOG4105EWI Short-chain dehydrogenase reductase Sdr A7A1_2537 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein A7A1_2539 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A7A1_2540 ENOG4106DF4 Sigma-70, region 4 A7A1_2541 ENOG4105F0F Oxalate decarboxylase A7A1_2543 ENOG4107RBB ABC transporter, permease A7A1_2544 ENOG4105C19 ABC transporter A7A1_2545 ENOG4108WMK Efflux transporter RND family MFP subunit A7A1_2546 ENOG4105E0A ABC, transporter A7A1_2547 ENOG4105EHG Permease protein A7A1_2548 ENOG4105DQ5 transport system permease protein A7A1_2550 ENOG4105D5Q Arginine ornithine antiporter A7A1_2552 ENOG4107K5X Membrane-bound metal-dependent hydrolase A7A1_2553 ENOG4107QZ2 Sulfatase A7A1_2554 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family A7A1_2555 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A7A1_2556 ENOG4105E0C molybdate abc transporter A7A1_2559 ENOG4105EEQ Na H antiporter A7A1_2560 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) A7A1_2561 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A7A1_2562 ENOG4105EEM helicase A7A1_2564 ENOG4105EN6 Membrane A7A1_2566 ENOG4107ZQN disulfide bond A7A1_2567 ENOG4105C59 p-type ATPase A7A1_2568 ENOG4105C59 p-type ATPase A7A1_2569 ENOG410681U heavy metal transport detoxification protein A7A1_2570 ENOG4105VPX protein, conserved in bacteria A7A1_2571 ENOG4105D9R oxidoreductase A7A1_2572 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) A7A1_2573 ENOG4105ME7 Membrane A7A1_2574 ENOG4105RXJ A7A1_2575 ENOG4105KPY Small multidrug resistance protein A7A1_2576 ENOG4105KBX Transcriptional regulator, TetR family A7A1_2577 ENOG4105EWI Short-chain dehydrogenase reductase Sdr A7A1_2579 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) A7A1_2580 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A7A1_2582 ENOG4105XZU Preprotein translocase, subunit SecG A7A1_2587 ENOG4105KVH Transcriptional regulator A7A1_2588 ENOG4105C8Q Methyl-accepting chemotaxis A7A1_2589 ENOG4105R40 Glycine betaine carnitine choline A7A1_2590 ENOG4108HQR Glycine betaine A7A1_2591 ENOG4105E90 ABC transporter A7A1_2592 ENOG4108IJ8 ABC transporter A7A1_2593 ENOG4107HG4 Transcriptional regulator A7A1_2595 ENOG4105H5S A7A1_2598 ENOG41082BM Transcriptional regulator, arsr family A7A1_2599 ENOG4105R40 Glycine betaine carnitine choline A7A1_2600 ENOG4108HQR Glycine betaine A7A1_2601 ENOG4105E90 ABC transporter A7A1_2602 ENOG4108IJ8 ABC transporter A7A1_2603 ENOG4107HG4 Transcriptional regulator A7A1_2604 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein A7A1_2605 ENOG4108QCI YvbH-like oligomerisation region A7A1_2607 ENOG4105T65 Membrane-associated protein A7A1_2608 ENOG4108W0I acetyltransferase A7A1_2609 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) A7A1_2610 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) A7A1_2611 ENOG4105CP7 Triose-phosphate isomerase A7A1_2612 ENOG4105BZA Phosphoglycerate kinase A7A1_2613 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A7A1_2616 ENOG4105CMD Transcriptional regulator, GntR family A7A1_2617 ENOG4105DEN Luciferase family A7A1_2618 ENOG4105GZI Transcriptional regulator A7A1_2619 ENOG4107RT3 EamA-like transporter family A7A1_2621 ENOG4105VRS hydrolase family 18 A7A1_2622 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) A7A1_2623 ENOG4107QR9 Iron-sulfur cluster binding protein A7A1_2624 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A7A1_2626 ENOG4105BZU Histidine kinase A7A1_2627 ENOG4105KCT ABC transporter A7A1_2628 ENOG4108M15 ABC transporter A7A1_2629 ENOG4107R6F Alpha Beta Hydrolase Fold protein A7A1_2630 ENOG4108MJI response regulator A7A1_2633 ENOG4105EG2 ABC transporter, permease A7A1_2635 ENOG4107FKK extracellular solute-binding protein family 1 A7A1_2637 ENOG4105JXH GntR family transcriptional regulator A7A1_2638 ENOG4105DAA L-lactate A7A1_2639 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A7A1_2641 ENOG4108ZPC Polysaccharide pyruvyl transferase A7A1_2642 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A7A1_2643 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family A7A1_2644 ENOG4105D3Q Sugar transferase A7A1_2647 ENOG4105K64 Glycosyl transferase, family 2 A7A1_2649 ENOG4107QRS glycosyltransferase group 2 family protein A7A1_2650 ENOG41068W6 Capsular polysaccharide biosynthesis protein A7A1_2651 ENOG4108KMV Glycosyl transferase (Group 1 A7A1_2652 ENOG4105K64 Glycosyl transferase, family 2 A7A1_2653 ENOG4108PQP glycosyl transferase group 1 A7A1_2655 ENOG4108QV3 biosynthesis protein A7A1_2656 ENOG4105HTX biosynthesis protein A7A1_2658 ENOG4105EBR Carboxylesterase A7A1_2659 ENOG4105PY6 Phenolic acid decarboxylase A7A1_2660 ENOG4105NI3 Protein of unknown function (DUF3237) A7A1_2661 ENOG4105NI3 Protein of unknown function (DUF3237) A7A1_2663 ENOG4105FQP Beta-lactamase A7A1_2664 ENOG4105EDQ levansucrase EC 2.4.1.10 A7A1_2665 ENOG4108HKT sucrose-6-phosphate hydrolase A7A1_2666 ENOG4107QTZ amino acid A7A1_2671 ENOG4105DNP FAD linked oxidase domain protein A7A1_2672 ENOG4105IRW patatin-like phospholipase family protein A7A1_2674 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A7A1_2675 ENOG4107URF beta-phospho-glucomutase A7A1_2676 ENOG4105CG3 alpha amylase, catalytic region A7A1_2679 ENOG4105EG2 ABC transporter, permease A7A1_2680 ENOG4105D56 permease protein A7A1_2681 ENOG4107FKK extracellular solute-binding protein family 1 A7A1_2682 ENOG4108IUK alpha amylase, catalytic A7A1_2683 ENOG4105FKQ transcriptional regulator A7A1_2684 ENOG4108URH decarboxylase A7A1_2685 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain A7A1_2686 ENOG4105CHH sulfate transporter A7A1_2687 ENOG4108V2W Carbonate dehydratase A7A1_2688 ENOG4105C5I Dehydrogenase A7A1_2690 ENOG4105C19 ABC transporter A7A1_2691 ENOG4105EWM Histidine kinase A7A1_2693 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase A7A1_2694 ENOG4105KRI phosphocarrier protein (HPr A7A1_2695 ENOG4105CIE May be required for sporulation (By similarity) A7A1_2696 ENOG4105CHW UPF0052 protein A7A1_2697 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A7A1_2698 ENOG4108Z4K mutator MutT protein A7A1_2699 ENOG4105C3M thioredoxin reductase A7A1_2702 ENOG4105BZ1 (ABC) transporter A7A1_2704 ENOG4106FGC A7A1_2707 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase A7A1_2708 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) A7A1_2709 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase A7A1_2710 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) A7A1_2711 ENOG4105ECC imidazole-glycerol-phosphate dehydratase A7A1_2712 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) A7A1_2713 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) A7A1_2714 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) A7A1_2716 ENOG4108E16 pectate lyase A7A1_2717 ENOG4108S4C acetyltransferase A7A1_2718 ENOG4107XGZ Hydrolase A7A1_2719 ENOG4105HKU nucleoside recognition domain-containing protein A7A1_2720 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) A7A1_2721 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) A7A1_2722 ENOG4105CE4 GlcNAc 6-P deacetylase A7A1_2723 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) A7A1_2724 ENOG4105FDP GntR family transcriptional regulator A7A1_2725 ENOG4105C1G acyl-Coa dehydrogenase A7A1_2727 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) A7A1_2729 ENOG410812K response regulator receiver protein A7A1_2730 ENOG4105D2N Aldolase A7A1_2731 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway A7A1_2732 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A7A1_2733 ENOG4105CBT Fructose-1,6-bisphosphatase A7A1_2734 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) A7A1_2735 ENOG41082DI 50s ribosomal protein l31 A7A1_2736 ENOG4107104 thymidine kinase A7A1_2737 ENOG4105C6K Malic enzyme A7A1_2738 ENOG4105EPI acetyltransferase, (GNAT) family A7A1_2742 ENOG41073R8 VanW family A7A1_2744 ENOG4105VMP Transcriptional regulator A7A1_2745 ENOG4105NX3 Membrane A7A1_2747 ENOG4108Q5Y Membrane A7A1_2749 ENOG4108V4B ThiJ pfpI A7A1_2750 ENOG4108J4B Beta-lactamase A7A1_2755 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) A7A1_2756 ENOG4107T94 Endo-14-beta-xylanase A7A1_2758 ENOG4108IMY Transcriptional regulator A7A1_2761 ENOG4105D3P Mannan endo-1,4-beta-mannosidase A7A1_2762 ENOG4105ETE Transcriptional regulator (LacI family A7A1_2763 ENOG4105CS2 ec 3.2.1.21 A7A1_2766 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component A7A1_2767 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component A7A1_2769 ENOG41066F8 ROK family A7A1_2770 ENOG4106ANW SMI1_KNR4 A7A1_2771 ENOG4106BHF A7A1_2774 ENOG4108Z7R Chaperone CsaA A7A1_2775 ENOG4105FTV AraC Family Transcriptional Regulator A7A1_2776 ENOG4108HJF gCN5-related N-acetyltransferase A7A1_2778 ENOG4108W8B Beta-lactamase domain protein A7A1_2780 ENOG4105D29 Helix-turn-helix type 11 domain protein A7A1_2782 ENOG4105KTU Transcriptional regulator, arsr family A7A1_2784 ENOG4108SJC Membrane A7A1_2788 ENOG4105ECK Fatty Acid Desaturase A7A1_2789 ENOG4108ZGX Histidine kinase A7A1_2790 ENOG4108S01 response regulator A7A1_2791 ENOG41069ER domain protein A7A1_2793 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) A7A1_2794 ENOG4105SCY DNAK suppressor A7A1_2801 ENOG4105C26 Dehydrogenase A7A1_2802 ENOG4105EWU Squalene--hopene cyclase A7A1_2803 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A7A1_2804 ENOG4105C8J )-transporter A7A1_2805 ENOG4105C09 Bile acid A7A1_2806 ENOG4105C7S Dehydrogenase A7A1_2809 ENOG4107T89 von Willebrand factor, type A A7A1_2810 ENOG4105GMT ATPase associated with various cellular activities aaa_5 A7A1_2812 ENOG4105K4H Nlp p60 protein A7A1_2813 ENOG41087PP glycosyltransferase MGT family A7A1_2815 ENOG4107QMU Mate efflux family protein A7A1_2816 ENOG4106SCS STAS domain A7A1_2820 ENOG4105FR1 rard protein A7A1_2823 ENOG4105C6Z Gluconate A7A1_2824 ENOG41090U3 tautomerase A7A1_2827 ENOG4105FBA Phospholipase Carboxylesterase A7A1_2829 ENOG4105E1V na solute symporter A7A1_2833 ENOG4108VXD carboxy-peptidase A7A1_2834 ENOG4105D3A purine nucleoside phosphorylase DeoD-type A7A1_2835 ENOG4106Z5R A7A1_2836 ENOG410841Q phosphoesterase PA-phosphatase related protein A7A1_2840 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein A7A1_2841 ENOG4108TSC N-acetyltransferase A7A1_2842 ENOG4107S4Y M20 DapE family protein YgeY A7A1_2845 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A7A1_2852 ENOG4107T32 3-phytase (EC 3.1.3.8) A7A1_2853 ENOG4105C5E polysaccharide biosynthesis protein A7A1_2854 ENOG4105E0X reductase A7A1_2855 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A7A1_2859 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) A7A1_2860 ENOG41090WU lipolytic protein G-D-S-L family A7A1_2861 ENOG4108KF3 Electron transport protein SCO1 SenC A7A1_2863 ENOG4105C7B Threonine dehydratase A7A1_2865 ENOG4108UT2 hemolysin iii A7A1_2867 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) A7A1_2868 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) A7A1_2871 ENOG4107YX5 Pfam:DUF548 A7A1_2872 ENOG4108Y6J UPF0403 protein A7A1_2873 ENOG4105C01 Dihydroxy-acid dehydratase A7A1_2876 ENOG4108V06 Glutathione peroxidase A7A1_2877 ENOG4105CVG Homoserine O-transsuccinylase A7A1_2885 ENOG41081VK Ribonuclease A7A1_2889 ENOG410890F Dynamin family A7A1_2891 ENOG41065KQ synthase A7A1_2892 ENOG4105C2W permease A7A1_2893 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) A7A1_2894 ENOG4105CTD carboxy-peptidase A7A1_2895 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) A7A1_2896 ENOG4108UHU Aldolase A7A1_2897 ENOG4105D7K pfkb domain protein A7A1_2898 ENOG4108M60 Transcriptional regulator A7A1_2900 ENOG4105CHR reductase A7A1_2901 ENOG4105DVT helicase A7A1_2905 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) A7A1_2908 ENOG4108UKS UPF0398 protein A7A1_2910 ENOG4107X2U Inherit from COG: Exonuclease-like protein A7A1_2911 ENOG4108I5C dEAD DEAH box helicase A7A1_2921 ENOG4105BZ4 penicillin-binding protein A7A1_2923 ENOG4105CSM endonuclease III A7A1_2925 ENOG4105C5S asparaginyl-tRNA synthetase A7A1_2926 ENOG4105CHM Aminotransferase A7A1_2928 ENOG4105YAC A7A1_2929 ENOG4105DVT helicase A7A1_2930 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) A7A1_2931 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) A7A1_2932 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) A7A1_2933 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase A7A1_2934 ENOG4105DJ0 Poly(A) Polymerase A7A1_2935 ENOG4105CPK Glycosyl transferase (Group 1 A7A1_2936 ENOG4105FJR Lmbe family A7A1_2937 ENOG4108Z5K methylglyoxal synthase A7A1_2938 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) A7A1_2939 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase A7A1_2940 ENOG4108JYZ YitT family A7A1_2944 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A7A1_2948 ENOG41068YB TPR repeat-containing protein A7A1_2949 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase A7A1_2951 ENOG4105CIH Imidazole acetol-phosphate transaminase A7A1_2953 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) A7A1_2954 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase A7A1_2956 ENOG4108I0Q anthranilate phosphoribosyltransferase A7A1_2957 ENOG4105CRQ synthase (Component I) A7A1_2958 ENOG4105KHN chorismate mutase A7A1_2959 ENOG4105D49 3-dehydroquinate synthase A7A1_2960 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A7A1_2961 ENOG4105BZU Histidine kinase A7A1_2962 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) A7A1_2963 ENOG4105EAH synthase A7A1_2964 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A7A1_2965 ENOG4105XXQ heptaprenyl diphosphate synthase component I A7A1_2967 ENOG4105EUJ GTP cyclohydrolase i A7A1_2968 ENOG4105K70 DNA-binding protein A7A1_2969 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) A7A1_2972 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase A7A1_2973 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) A7A1_2974 ENOG4105S2F A7A1_2976 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) A7A1_2977 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) A7A1_2978 ENOG4105CAT Cytidine monophosphate kinase A7A1_2981 ENOG4105MSI germination protein ypeb A7A1_2983 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) A7A1_2984 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase A7A1_2987 ENOG4107RGJ metallophosphoesterase A7A1_2990 ENOG4105I7S Abortive infection protein A7A1_2991 ENOG4105C9U ATP-dependent DNA helicase RecQ A7A1_2992 ENOG4105T7X A7A1_2994 ENOG4108SAX Membrane A7A1_2996 ENOG4108JQ1 Dehydrogenase A7A1_2997 ENOG4105FF2 Type I DHQase A7A1_3000 ENOG4105BZU Histidine kinase A7A1_3001 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A7A1_3002 ENOG4105CRE cytochrome C A7A1_3003 ENOG4107TWT Cytochrome c biogenesis protein A7A1_3005 ENOG4105FE9 pseudouridine synthase A7A1_3007 ENOG4108JIC nucleoside recognition domain protein A7A1_3008 ENOG4105DZ1 carboxypeptidase A7A1_3010 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) A7A1_3011 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) A7A1_3014 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) A7A1_3015 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) A7A1_3016 ENOG4108R6K riboflavin synthase, subunit alpha A7A1_3017 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) A7A1_3021 ENOG4105C3F Signal peptidase i A7A1_3025 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) A7A1_3029 ENOG4107ZE5 PPIases accelerate the folding of proteins A7A1_3030 ENOG4105PTM secreted protein A7A1_3031 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) A7A1_3033 ENOG4105G6R Stage v sporulation protein ae A7A1_3035 ENOG4105CZ3 stage V sporulation protein ad A7A1_3036 ENOG41090VF Stage v sporulation protein ac A7A1_3039 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A7A1_3040 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) A7A1_3041 ENOG41082AN stage II sporulation protein A7A1_3042 ENOG4105DZ1 carboxypeptidase A7A1_3043 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) A7A1_3044 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) A7A1_3045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A7A1_3046 ENOG4105I3K Ferric uptake regulator, Fur family A7A1_3047 ENOG4105MZ9 stage II sporulation protein m A7A1_3050 ENOG4105DFD Na H antiporter A7A1_3051 ENOG4108IJ0 Aspartate ammonia-lyase A7A1_3052 ENOG4105HDK L-asparaginase A7A1_3053 ENOG4108IMY Transcriptional regulator A7A1_3055 ENOG4108YZ4 nudix hydrolase A7A1_3056 ENOG4105CPC Aldo Keto reductase A7A1_3060 ENOG4106HZJ A7A1_3061 ENOG4105RHY Pfam:UPF0157 A7A1_3062 ENOG4105KAC Antibiotic biosynthesis monooxygenase A7A1_3063 ENOG4108XET gCN5-related N-acetyltransferase A7A1_3065 ENOG41061CK Antibiotic biosynthesis monooxygenase A7A1_3067 ENOG4105XJB lipolytic protein G-D-S-L family A7A1_3068 ENOG4107258 Transcriptional regulator A7A1_3070 ENOG4105P4J Allophanate hydrolase, subunit 1 A7A1_3071 ENOG4105CFM UPF0317 protein A7A1_3072 ENOG4105C5A transporter A7A1_3073 ENOG4105E7W lamb ycsf family protein A7A1_3077 ENOG4108ZX0 Signal peptidase I A7A1_3078 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A7A1_3082 ENOG4108ZYE Transcriptional regulator A7A1_3083 ENOG4108T5E Copper resistance protein A7A1_3084 ENOG4105KTB nuclear export factor GLE1 A7A1_3085 ENOG4105H9W Short-chain dehydrogenase reductase Sdr A7A1_3087 ENOG4105C26 Dehydrogenase A7A1_3088 ENOG4108JPW Aminotransferase A7A1_3090 ENOG4105YVS arsR family transcriptional regulator A7A1_3091 ENOG41067V3 Antibiotic biosynthesis monooxygenase A7A1_3092 ENOG4108DBC nitroreductase A7A1_3093 ENOG4105R8C Transcriptional regulator A7A1_3096 ENOG4108IPW abc transporter atp-binding protein A7A1_3097 ENOG4105CM4 permease protein A7A1_3098 ENOG4105DHS permease protein A7A1_3099 ENOG4105CFH Aspartokinase A7A1_3102 ENOG4105BZU Histidine kinase A7A1_3103 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A7A1_3107 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) A7A1_3108 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit A7A1_3109 ENOG4105C83 adenylosuccinate lyase A7A1_3110 ENOG4105C8V SAICAR synthetase A7A1_3111 ENOG4105VR9 phosphoribosylformylglycinamidine synthase A7A1_3112 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I A7A1_3113 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii A7A1_3115 ENOG4105CXB phosphoribosylaminoimidazole synthetase A7A1_3116 ENOG4108V3E phosphoribosylglycinamide formyltransferase A7A1_3117 ENOG4105DC1 bifunctional purine biosynthesis protein purh A7A1_3118 ENOG4105C12 Phosphoribosylglycinamide synthetase A7A1_3120 ENOG4105DVH amino acid A7A1_3122 ENOG4108R5T secreted protein A7A1_3123 ENOG4105KGF protein, YerC YecD A7A1_3124 ENOG4105CBC glutamate synthase A7A1_3125 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) A7A1_3126 ENOG4105C4R Atp-dependent dna helicase A7A1_3127 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) A7A1_3129 ENOG4105CRN Aminoglycoside phosphotransferase A7A1_3130 ENOG4105KT7 mgtC SapB transporter A7A1_3131 ENOG4105CK7 Sodium proline symporter A7A1_3132 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A7A1_3133 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A7A1_3134 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A7A1_3135 ENOG4108IG5 Transcriptional regulator A7A1_3137 ENOG4105CBD Diacylglycerol kinase A7A1_3138 ENOG4105C28 cystathionine A7A1_3139 ENOG4105C28 cystathionine A7A1_3140 ENOG4105D9U N-acetyltransferase A7A1_3141 ENOG4105JHY Membrane A7A1_3142 ENOG4108N23 SpoOM-related protein A7A1_3144 ENOG4105EC3 peptidase S51, dipeptidase E A7A1_3145 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A7A1_3146 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) A7A1_3147 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) A7A1_3151 ENOG4108TDW sporulation protein YtxC A7A1_3152 ENOG4105C22 threonyL-tRNA synthetase A7A1_3153 ENOG4105U0R haloacid dehalogenase-like hydrolase A7A1_3154 ENOG4108HRK Histidine kinase A7A1_3155 ENOG4105DY9 regulatoR A7A1_3157 ENOG41067MG lrgb family A7A1_3160 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) A7A1_3161 ENOG4105VJV 50s ribosomal protein L35 A7A1_3162 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) A7A1_3163 ENOG410696E Membrane A7A1_3165 ENOG4105CN9 Peptidase m42 family protein A7A1_3166 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase A7A1_3168 ENOG4105EF1 ribulokinase A7A1_3169 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase A7A1_3171 ENOG4108MDK Dehydrogenase A7A1_3174 ENOG4105DRS transport system, permease A7A1_3175 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) A7A1_3178 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A7A1_3179 ENOG4105CQB FAD linked oxidase domain protein A7A1_3181 ENOG41067MF small acid-soluble spore protein A7A1_3182 ENOG4108RWN rrna methyltransferase A7A1_3183 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) A7A1_3184 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A7A1_3185 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A7A1_3188 ENOG4105DCG PHP domain protein A7A1_3189 ENOG4105C98 muts2 protein A7A1_3191 ENOG4105CEY Amp-dependent synthetase and ligase A7A1_3192 ENOG4107Z3H Transcriptional regulator, TetR family A7A1_3193 ENOG41060WC Enoyl-CoA hydratase A7A1_3194 ENOG4105BZJ Electron transfer flavoprotein A7A1_3195 ENOG4105C10 Electron transfer flavoprotein A7A1_3196 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) A7A1_3197 ENOG4105K63 Thioredoxin A7A1_3199 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) A7A1_3200 ENOG4105CSA Coproporphyrinogen iii oxidase A7A1_3201 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) A7A1_3202 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ A7A1_3203 ENOG4105CFG Acts as a chaperone (By similarity) A7A1_3205 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) A7A1_3206 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) A7A1_3207 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A7A1_3210 ENOG4105KTH gatB Yqey A7A1_3211 ENOG4105F7J membrane-bound serine protease A7A1_3212 ENOG4105DI5 UPF0365 protein A7A1_3214 ENOG41068P3 sporulation protein YqfC A7A1_3215 ENOG4105EI1 sporulation protein yqfd A7A1_3216 ENOG4105C9A Phoh family A7A1_3217 ENOG4105CTJ Metal Dependent Phosphohydrolase A7A1_3218 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) A7A1_3219 ENOG4107YR5 Diacylglycerol kinase A7A1_3220 ENOG4105KG3 cytidine deaminase A7A1_3221 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A7A1_3222 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) A7A1_3223 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit A7A1_3224 ENOG4105C38 Glycyl-tRNA synthetase beta subunit A7A1_3226 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) A7A1_3227 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 A7A1_3228 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A7A1_3229 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A7A1_3232 ENOG4105EGD dinuclear metal center protein, YbgI family A7A1_3233 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) A7A1_3235 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase A7A1_3239 ENOG4105CSV Glutaminase A7A1_3241 ENOG4108J5H Homocysteine s-methyltransferase A7A1_3242 ENOG4108IQI permease A7A1_3243 ENOG4105CM2 brancheD-chain amino acid aminotransferase A7A1_3245 ENOG4108X79 transcriptional regulator A7A1_3246 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) A7A1_3247 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane A7A1_3249 ENOG4105C72 UPF0176 protein A7A1_3253 ENOG4107ZTW SNARE associated Golgi A7A1_3254 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase A7A1_3255 ENOG4108WC5 Alpha Beta Hydrolase Fold protein A7A1_3257 ENOG4108TCS Glutamyl endopeptidase A7A1_3258 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR A7A1_3259 ENOG4106BHF A7A1_3260 ENOG41065RQ ADP-ribosylation crystallin J1 A7A1_3261 ENOG4106AXJ AraC family transcriptional regulator A7A1_3262 ENOG410631K Membrane A7A1_3265 ENOG4105DCM major facilitator superfamily A7A1_3266 ENOG410645S MarR family Transcriptional regulator A7A1_3268 ENOG4105CXY transporter A7A1_3269 ENOG4107VXM glycerophosphoryl diester phosphodiesterase A7A1_3270 ENOG4107QTZ amino acid A7A1_3272 ENOG4107E6A Cytochrome p-450 A7A1_3273 ENOG4108HWY Beta-lactamase A7A1_3274 ENOG4106DDH Sporulation-specific SASP protein A7A1_3276 ENOG4106K80 A7A1_3278 ENOG4105G0J serine threonine protein kinase A7A1_3286 ENOG4108WUZ (ABC) transporter A7A1_3287 ENOG41066N6 Abortive infection protein A7A1_3288 ENOG41066N6 Abortive infection protein A7A1_3289 ENOG4107ZBH radical SAM domain protein A7A1_3292 ENOG4108RWP Major Facilitator Superfamily protein A7A1_3293 ENOG4105WAB arsR family transcriptional regulator A7A1_3294 ENOG4105GPN Uncharacterized conserved protein (DUF2294) A7A1_3299 ENOG4108TWJ NADH dehydrogenase subunit 5 A7A1_3300 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A7A1_3302 ENOG4105D03 DNA-3-methyladenine glycosylase II A7A1_3304 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) A7A1_3305 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) A7A1_3306 ENOG4107U5W ybbr family A7A1_3307 ENOG4105C8B TIGR00159 family A7A1_3309 ENOG4105EMN RNA polymerase sigma factor A7A1_3314 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) A7A1_3316 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A7A1_3317 ENOG4105C54 Major Facilitator superfamily A7A1_3318 ENOG4107Y9E nuclease A7A1_3319 ENOG4105CMG Carbohydrate kinase A7A1_3320 ENOG4105C93 Xylose Isomerase A7A1_3321 ENOG4105E2R ROK family A7A1_3322 ENOG4105DSG hydrolase family 43 A7A1_3323 ENOG4105CT4 transporter A7A1_3324 ENOG410907G A7A1_3327 ENOG4107NTZ A7A1_3334 ENOG41079P0 A7A1_3335 ENOG4105C5F glutamine synthetase A7A1_3336 ENOG4105KV4 Transcriptional regulator A7A1_3337 ENOG4105CXI aluminum resistance protein A7A1_3338 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A7A1_3339 ENOG4106F1P AAA ATPase, central domain protein A7A1_3340 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A7A1_3341 ENOG4105U6W MutT NUDIX family protein A7A1_3342 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) A7A1_3345 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A7A1_3346 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) A7A1_3350 ENOG410814C multidrug resistance protein A7A1_3351 ENOG4108X3M OsmC Ohr family protein A7A1_3352 ENOG4105K7W phage-related replication protein A7A1_3354 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin A7A1_3357 ENOG4106A3M Cytochrome p-450 A7A1_3359 ENOG4105C0W non-ribosomal peptide synthetase A7A1_3360 ENOG4105C0W non-ribosomal peptide synthetase A7A1_3361 ENOG4105C0W non-ribosomal peptide synthetase A7A1_3362 ENOG4105C0W non-ribosomal peptide synthetase A7A1_3366 ENOG4107SQU synthase A7A1_3367 ENOG4107SQU synthase A7A1_3368 ENOG4105C0W non-ribosomal peptide synthetase A7A1_3369 ENOG4108KQ6 Enoyl-CoA hydratase A7A1_3370 ENOG4108MGH Enoyl-CoA hydratase A7A1_3371 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase A7A1_3372 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase A7A1_3373 ENOG41062T2 Acyl carrier protein A7A1_3374 ENOG4107QKG PfaD family A7A1_3376 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A7A1_3378 ENOG4108151 Beta-lactamase domain protein A7A1_3379 ENOG4105W1N transcriptional regulator A7A1_3380 ENOG4105IIP Membrane A7A1_3382 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) A7A1_3383 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) A7A1_3386 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A7A1_3387 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A7A1_3389 ENOG4105MCT stage V sporulation protein S A7A1_3390 ENOG4105D48 metallophosphoesterase A7A1_3391 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) A7A1_3392 ENOG4108A04 Beta-lactamase A7A1_3394 ENOG4105CEV competence damage-inducible protein A7A1_3395 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase A7A1_3398 ENOG4105XZV Protein of unknown function (DUF3243) A7A1_3399 ENOG4108RKS Short-chain dehydrogenase reductase Sdr A7A1_3403 ENOG4105FDP GntR family transcriptional regulator A7A1_3404 ENOG4105CNU cell division protein FtsK A7A1_3405 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit A7A1_3407 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A7A1_3409 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A7A1_3410 ENOG4108S0H Dipicolinic acid synthetase, b subunit A7A1_3411 ENOG4105E35 Dipicolinate synthase subunit A A7A1_3413 ENOG4105C1V Peptidase, M16 A7A1_3415 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) A7A1_3416 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) A7A1_3417 ENOG4105DTN riboflavin biosynthesis protein ribF A7A1_3418 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) A7A1_3419 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) A7A1_3420 ENOG4105W7A Protein of unknown function (DUF503) A7A1_3421 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) A7A1_3422 ENOG4105VHM ribosomal protein A7A1_3423 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination A7A1_3424 ENOG4105CHV Transcription elongation factor NusA A7A1_3425 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) A7A1_3426 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A7A1_3427 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) A7A1_3428 ENOG4105DZP Membrane-associated zinc metalloprotease A7A1_3430 ENOG4105KNE Phosphatidate cytidylyltransferase A7A1_3431 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A7A1_3432 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) A7A1_3434 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) A7A1_3435 ENOG4105CE9 30S ribosomal protein S2 A7A1_3437 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A7A1_3440 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis A7A1_3441 ENOG4105CBS Chea signal transduction histidine kinase A7A1_3442 ENOG4105CBS Chea signal transduction histidine kinase A7A1_3443 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) A7A1_3445 ENOG4105FZW flagellar biosynthesis regulator FlhF A7A1_3446 ENOG4105D7B Flagellar biosynthesis protein flha A7A1_3447 ENOG4105D00 flagellar biosynthetic protein flhB A7A1_3448 ENOG4105D19 Role in flagellar biosynthesis (By similarity) A7A1_3449 ENOG4105VS8 Flagellar biosynthetic protein fliq A7A1_3450 ENOG4105CN7 Flagellar biosynthetic protein FliP A7A1_3452 ENOG4107YTP response regulator receiver protein A7A1_3453 ENOG4105DD5 Flagellar motor switch protein A7A1_3454 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A7A1_3456 ENOG4108JQA flagellar A7A1_3457 ENOG410822I Flagellar hook capping protein A7A1_3458 ENOG410696Y Flagellar hook-length control protein A7A1_3460 ENOG4106YF4 Flagellar biosynthesis chaperone A7A1_3463 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A7A1_3464 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) A7A1_3465 ENOG4105VQ0 flagellar hook-basal body complex protein fliE A7A1_3466 ENOG4108ZC9 flagellar basal-body rod protein flgc A7A1_3467 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) A7A1_3469 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) A7A1_3470 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) A7A1_3471 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A7A1_3472 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) A7A1_3473 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A7A1_3474 ENOG4105C79 DNA protecting protein DprA A7A1_3475 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha A7A1_3476 ENOG4105CMV Succinyl-CoA synthetase subunit beta A7A1_3477 ENOG4105VM1 flagellar A7A1_3479 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A7A1_3480 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) A7A1_3481 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) A7A1_3482 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) A7A1_3483 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) A7A1_3485 ENOG4108BW8 UPF0109 protein A7A1_3486 ENOG4105K5M 30s ribosomal protein S16 A7A1_3488 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) A7A1_3490 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A7A1_3491 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) A7A1_3492 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) A7A1_3493 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A7A1_3494 ENOG4105CHR reductase A7A1_3495 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A7A1_3497 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) A7A1_3498 ENOG4105CB5 ATP-dependent DNA helicase recG A7A1_3499 ENOG4105EJQ L-serine dehydratase A7A1_3501 ENOG4105DP4 dak2 domain fusion protein ylov A7A1_3502 ENOG4108ZAA Alkaline-shock protein A7A1_3505 ENOG4105FJ0 thiamine A7A1_3506 ENOG4105DJV ribulose-phosphate 3-epimerase A7A1_3507 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) A7A1_3508 ENOG4105D9P serine threonine protein kinase A7A1_3509 ENOG4108ZF3 Phosphatase A7A1_3510 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs A7A1_3511 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A7A1_3512 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) A7A1_3513 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A7A1_3514 ENOG4105C25 Primosomal protein n' A7A1_3515 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A7A1_3517 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) A7A1_3518 ENOG4105KC4 UPF0296 protein A7A1_3519 ENOG4105DSJ YicC domain protein A7A1_3521 ENOG4105F23 Fibronectin-binding protein A7A1_3522 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein A7A1_3523 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A7A1_3524 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A7A1_3525 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) A7A1_3526 ENOG4107S4M Sulfate adenylate transferase A7A1_3528 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) A7A1_3529 ENOG41069ZM Protein of unknown function (DUF2624) A7A1_3530 ENOG4108JYZ YitT family A7A1_3531 ENOG4105N80 Ferric uptake regulator, Fur family A7A1_3532 ENOG4108U5J '-nucleotidase A7A1_3533 ENOG41063Y9 A7A1_3534 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) A7A1_3538 ENOG4105SXS Protein of unknown function (DUF456) A7A1_3539 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A7A1_3541 ENOG4107RF6 penicillin-binding protein A7A1_3542 ENOG4105CVA phosphate A7A1_3543 ENOG4105C8U phosphate abc transporter A7A1_3544 ENOG4105E2Z phosphate ABC transporter (Permease A7A1_3545 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A7A1_3546 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A7A1_3547 ENOG41068DG YceG-like family A7A1_3551 ENOG4105WDJ 50S ribosomal protein L33 A7A1_3552 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase A7A1_3554 ENOG4107ZXI Rhomboid family A7A1_3557 ENOG4105E0M Sulfatase A7A1_3562 ENOG4105C5X domain protein A7A1_3566 ENOG4105C37 (CBS) domain A7A1_3578 ENOG4105VFR signal peptidase A7A1_3580 ENOG4108IMY Transcriptional regulator A7A1_3583 ENOG4105C0D helicase A7A1_3585 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) A7A1_3586 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor A7A1_3587 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor A7A1_3588 ENOG4105WZW rhodanese family A7A1_3589 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) A7A1_3590 ENOG4105KST dependent repressor A7A1_3593 ENOG4105CBJ Metal-dependent enzyme A7A1_3595 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) A7A1_3596 ENOG4105DC7 peptidase M24 A7A1_3597 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) A7A1_3599 ENOG4105CD2 stage iii sporulation protein aa A7A1_3600 ENOG4105KR5 Stage iii sporulation protein A7A1_3601 ENOG4108CQH stage III sporulation protein AC A7A1_3602 ENOG4105KQ4 Stage iii sporulation protein ad A7A1_3604 ENOG410644B Stage III sporulation protein af A7A1_3608 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A7A1_3609 ENOG4108ZSR alkaline shock protein A7A1_3610 ENOG4105M7K Involved in the transcription termination process (By similarity) A7A1_3611 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) A7A1_3612 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A7A1_3613 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A7A1_3614 ENOG4105CTB Polyprenyl synthetase A7A1_3616 ENOG4105DX0 Hemolysin A A7A1_3617 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) A7A1_3618 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) A7A1_3619 ENOG4105S1Z Stage IV sporulation protein B A7A1_3620 ENOG4107QQR Sporulation A7A1_3621 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A7A1_3623 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A7A1_3624 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A7A1_3626 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A7A1_3627 ENOG4105C1G acyl-Coa dehydrogenase A7A1_3629 ENOG4105DXD 2-methylcitrate dehydratase A7A1_3630 ENOG4105CR4 methylisocitrate lyase A7A1_3632 ENOG4106CCJ Protein of unknown function (DUF2627) A7A1_3633 ENOG4108JUB Transcriptional regulator A7A1_3635 ENOG4107RDP Dehydrogenase A7A1_3636 ENOG4105CKM Branched-chain carboxylic acid kinase A7A1_3639 ENOG4105CPP Dehydrogenase, E1 component A7A1_3640 ENOG4105C7S Dehydrogenase A7A1_3643 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) A7A1_3644 ENOG4108Y6J UPF0403 protein A7A1_3645 ENOG4108HW3 (ABC) transporter A7A1_3646 ENOG4105E5Q amino acid AbC transporter A7A1_3647 ENOG4105CDA abc transporter atp-binding protein A7A1_3648 ENOG4108QEG Membrane A7A1_3649 ENOG4108VZI ErfK ybiS ycfS ynhG family protein A7A1_3650 ENOG4108ZVT methylmalonyl-coA epimerase A7A1_3651 ENOG4108HNZ carboxyl transferase A7A1_3652 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) A7A1_3653 ENOG4108NA0 Uncharacterized conserved protein (COG2071) A7A1_3654 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) A7A1_3656 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A7A1_3657 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) A7A1_3658 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A7A1_3659 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) A7A1_3660 ENOG410861F 50S ribosomal protein L33 A7A1_3662 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A7A1_3664 ENOG4105II7 pyrroline-5-carboxylate reductase A7A1_3665 ENOG41069FQ Metallo-beta-lactamase superfamily A7A1_3666 ENOG4108IXY short-chain dehydrogenase reductase A7A1_3669 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase A7A1_3671 ENOG4105E5W Transporter A7A1_3675 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding A7A1_3676 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) A7A1_3677 ENOG4106K7D Major facilitator family transporter A7A1_3680 ENOG4105TRI Hydrolase A7A1_3683 ENOG4108INS Transcriptional regulator A7A1_3684 ENOG4107SCK Monooxygenase A7A1_3687 ENOG41060YP A7A1_3688 ENOG4106CAD Protein of unknown function (DUF3311) A7A1_3689 ENOG4105E1V na solute symporter A7A1_3690 ENOG4105X3H Excalibur domain protein A7A1_3691 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A7A1_3692 ENOG4105XVF Competence transcription factor A7A1_3696 ENOG4106YBV Methyl-accepting chemotaxis A7A1_3697 ENOG4107ZYJ bioY protein A7A1_3698 ENOG4107F3J Amp-dependent synthetase and ligase A7A1_3700 ENOG4107TB6 phosphoglycerate mutase A7A1_3701 ENOG4108HUF Transporter A7A1_3703 ENOG4105KD7 acetyltransferase A7A1_3705 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 A7A1_3707 ENOG4105CEY Amp-dependent synthetase and ligase A7A1_3709 ENOG4105DF9 Lipoate-protein, ligase A7A1_3710 ENOG4108RQ5 Beta-lactamase domain-containing protein A7A1_3711 ENOG4106AXD A7A1_3714 ENOG4105DER m42 family A7A1_3716 ENOG41090T1 Membrane A7A1_3718 ENOG4105ECB domain protein A7A1_3720 ENOG4105C1Q protoporphyrinogen oxidase A7A1_3721 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A7A1_3725 ENOG4105K59 histidine triad (HIT) protein A7A1_3726 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) A7A1_3727 ENOG4105NBU tryptophan transport protein A7A1_3733 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A7A1_3735 ENOG4105EQI Metal Dependent Phosphohydrolase A7A1_3736 ENOG4106D4I domain protein A7A1_3737 ENOG4107VRP DNA repair exonuclease A7A1_3738 ENOG4105RHA ABC transporter, permease A7A1_3739 ENOG4108IUX (ABC) transporter A7A1_3740 ENOG4105CGU Enoyl-CoA hydratase A7A1_3742 ENOG4105NCW Trka-c domain protein A7A1_3743 ENOG4107S91 Sodium hydrogen exchanger A7A1_3744 ENOG4105D4P Coproporphyrinogen iii oxidase A7A1_3747 ENOG4105F1N DNA alkylation repair A7A1_3748 ENOG4105WZB UPF0342 protein A7A1_3749 ENOG4106MP8 UPF0754 membrane protein A7A1_3751 ENOG410839P A7A1_3756 ENOG4105BZ1 (ABC) transporter A7A1_3757 ENOG4105BZ1 (ABC) transporter A7A1_3760 ENOG4105F0I Aminotransferase A7A1_3761 ENOG4107VMI polysaccharide deacetylase A7A1_3762 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) A7A1_3763 ENOG4105D64 Mechanosensitive ion channel A7A1_3765 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A7A1_3766 ENOG4105WMR Protein CrcB homolog A7A1_3768 ENOG4105C37 (CBS) domain A7A1_3770 ENOG4105CHM Aminotransferase A7A1_3772 ENOG4105C37 (CBS) domain A7A1_3773 ENOG4105F6E Acyl-transferase A7A1_3774 ENOG4108FN7 Aldo keto reductase A7A1_3775 ENOG4108AEY RNA polymerase sigma factor A7A1_3776 ENOG4105J37 A7A1_3779 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A7A1_3780 ENOG4105C8J )-transporter A7A1_3781 ENOG4105CUB amino acid A7A1_3782 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A7A1_3783 ENOG4105BZN citrate synthase A7A1_3786 ENOG4105G6Z alkaline phosphatase A7A1_3787 ENOG4105ED1 spovr family A7A1_3794 ENOG4105WH1 Two component transcriptional regulator luxr family A7A1_3795 ENOG4105BZU Histidine kinase A7A1_3797 ENOG4105C6V Glycerol-3-phosphate dehydrogenase A7A1_3798 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) A7A1_3800 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator A7A1_3801 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A7A1_3802 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A7A1_3803 ENOG4107YBY Hydrolase A7A1_3804 ENOG41080XP Cbs domain A7A1_3806 ENOG4108YBP pseudouridine synthase A7A1_3815 ENOG4105BZU Histidine kinase A7A1_3817 ENOG4105VEQ Cold shock protein A7A1_3818 ENOG4108TU7 Inherit from COG: (ABC) transporter A7A1_3819 ENOG4105CJ1 ABC, transporter A7A1_3820 ENOG4105CZV ABC transporter A7A1_3821 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family A7A1_3824 ENOG4105CS1 NAD(P)H quinone oxidoreductase A7A1_3825 ENOG4105C0R drug resistance transporter emrb qaca subfamily A7A1_3826 ENOG4105CW7 secretion protein, HlyD family A7A1_3827 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes A7A1_3828 ENOG4106AKX UPF0229 protein A7A1_3829 ENOG4105CYN Serine protein kinase A7A1_3833 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) A7A1_3836 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) A7A1_3837 ENOG4107D63 A7A1_3838 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) A7A1_3840 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) A7A1_3841 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component A7A1_3842 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein A7A1_3843 ENOG4105E2Y ABC, transporter A7A1_3846 ENOG4105DNP FAD linked oxidase domain protein A7A1_3847 ENOG4105C3G gtp-binding protein A7A1_3859 ENOG41088CQ domain protein A7A1_3862 ENOG4107EV6 Inherit from COG: YD repeat protein A7A1_3871 ENOG4105CS2 ec 3.2.1.21 A7A1_3882 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A7A1_3886 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A7A1_3889 ENOG4105BZ4 penicillin-binding protein A7A1_3890 ENOG4105BZ4 penicillin-binding protein A7A1_3893 ENOG4105BZ4 penicillin-binding protein A7A1_3894 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A7A1_3897 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A7A1_3904 ENOG4108YX9 iron--sulfur cluster insertion protein erpA A7A1_3914 ENOG4106A3M Cytochrome p-450 A7A1_3915 ENOG41088CQ domain protein A7A1_3916 ENOG4106A3M Cytochrome p-450 A7A1_3924 ENOG4105CS2 ec 3.2.1.21 A7A1_3928 ENOG4105CS2 ec 3.2.1.21 A7A1_3929 ENOG4105CS2 ec 3.2.1.21 A7A1_3932 ENOG4105CS2 ec 3.2.1.21 A7A1_3935 ENOG4108RZ2 Glycoside hydrolase family 16 A7A1_3943 ENOG4105C6K Malic enzyme A7A1_3944 ENOG4105C5T Phosphoribosyl pyrophosphate synthase A7A1_3946 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)