locus-tag class description I33_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) I33_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) I33_0003 ENOG410848D S4 domain protein YaaA I33_0006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I33_0007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I33_0014 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) I33_0016 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) I33_0017 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) I33_0018 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) I33_0020 ENOG4105ZMH deoxynucleoside kinase I33_0023 ENOG4105GTG Isochorismatase I33_0024 ENOG4108Z6B deaminase I33_0025 ENOG4105C6E dna polymerase iii I33_0026 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) I33_0027 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) I33_0029 ENOG41067KS pro-sigma K processing I33_0037 ENOG4105CDW Resistance protein I33_0038 ENOG4105CXN decarboxylase I33_0039 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) I33_0040 ENOG4105X0R protein from nitrogen regulatory protein P-II I33_0041 ENOG4105XVJ Protein of unknown function (DUF327) I33_0042 ENOG4105FA2 dna polymerase iii I33_0043 ENOG4105MA4 psp1 domain protein I33_0044 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) I33_0045 ENOG41060K3 Methyltransferase I33_0046 ENOG4105VC4 domain protein I33_0047 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) I33_0048 ENOG4105KRN Transcriptional regulator, abrb family I33_0049 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) I33_0050 ENOG4105F8V Hydrolase, tatD family I33_0051 ENOG41069ER domain protein I33_0053 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) I33_0054 ENOG4105XFA sporulation peptidase YabG I33_0055 ENOG4105W42 Veg protein I33_0056 ENOG4105XEW small acid-soluble spore protein I33_0057 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) I33_0058 ENOG4105DFT pur operon repressor I33_0059 ENOG4105KME endoribonuclease L-psp I33_0060 ENOG4105K4W Could be involved in septation (By similarity) I33_0062 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) I33_0063 ENOG4105C5T Phosphoribosyl pyrophosphate synthase I33_0064 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) I33_0065 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) I33_0067 ENOG4108JA2 transcriptioN-repair coupling factor I33_0068 ENOG4108M14 stage v sporulation protein t I33_0070 ENOG4108IY2 MazG family I33_0071 ENOG41082I2 s4 domain protein I33_0072 ENOG4105VYY sporulation protein yabp I33_0075 ENOG41060GV RNA binding s1 domain protein I33_0081 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) I33_0082 ENOG4108UGV hypoxanthine phosphoribosyltransferase I33_0083 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) I33_0085 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) I33_0086 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase I33_0087 ENOG4105C6T cysteine synthase I33_0088 ENOG4105CRQ synthase (Component I) I33_0089 ENOG4105DDQ anthranilate synthase I33_0090 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 I33_0091 ENOG4105EEI dihydropteroate synthase I33_0092 ENOG4105KRF dihydroneopterin aldolase I33_0093 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase I33_0095 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) I33_0096 ENOG4105CRK lysyL-tRNA synthetase I33_0114 ENOG4108Z0C Uvrb UvrC protein I33_0115 ENOG41066A3 ATP guanido phosphotransferase I33_0117 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) I33_0118 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) I33_0119 ENOG4105CTP PilT protein domain protein I33_0120 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) I33_0121 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) I33_0122 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) I33_0124 ENOG4105D7W serine acetyltransferase I33_0125 ENOG4105C8N cysteinyl-tRNA synthetase I33_0126 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) I33_0127 ENOG4105C2N RNA methyltransferase TrmH family group 3 I33_0128 ENOG4105M0M Tetracycline resistance protein I33_0131 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) I33_0132 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) I33_0134 ENOG4108VZM 50s ribosomal protein L10 I33_0135 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) I33_0136 ENOG4107Y49 methyltransferase I33_0137 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) I33_0138 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) I33_0140 ENOG4105XPM ribosomal protein I33_0141 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) I33_0142 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) I33_0143 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) I33_0144 ENOG4107SKW Inherit from COG: Alpha beta hydrolase I33_0145 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) I33_0146 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) I33_0147 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) I33_0148 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) I33_0149 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity I33_0150 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) I33_0151 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) I33_0152 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) I33_0153 ENOG41082SA 50s ribosomal protein l29 I33_0154 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal I33_0156 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits I33_0158 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) I33_0159 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) I33_0160 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) I33_0161 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) I33_0162 ENOG4105VPB 50S ribosomal protein L30 I33_0163 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) I33_0164 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) I33_0166 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) I33_0169 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits I33_0170 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) I33_0171 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) I33_0172 ENOG4108ZT0 50S ribosomal protein l17 I33_0173 ENOG4108JJB ABC transporter I33_0174 ENOG4108JJB ABC transporter I33_0175 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) I33_0176 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) I33_0177 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) I33_0178 ENOG4108UJD 30S ribosomal protein S9 I33_0179 ENOG4108I0C methyltransferase I33_0182 ENOG4105D1F ATP-binding protein I33_0185 ENOG4108NMV polysaccharide deacetylase I33_0203 ENOG4105CHH sulfate transporter I33_0205 ENOG4108SA1 esterase I33_0209 ENOG410874W AraC family transcriptional regulator I33_0210 ENOG4105EHZ conserved protein UCP016719 I33_0211 ENOG4105D17 glycoside hydrolase, family 3 domain protein I33_0215 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate I33_0217 ENOG4105EWC Purine nucleoside phosphorylase I33_0223 ENOG4105EMN RNA polymerase sigma factor I33_0225 ENOG4105C8B TIGR00159 family I33_0226 ENOG4107U5W ybbr family I33_0227 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) I33_0229 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) I33_0230 ENOG4108TWJ NADH dehydrogenase subunit 5 I33_0234 ENOG4105GPN Uncharacterized conserved protein (DUF2294) I33_0235 ENOG4105WAB arsR family transcriptional regulator I33_0237 ENOG4108RWP Major Facilitator Superfamily protein I33_0240 ENOG4105G0J serine threonine protein kinase I33_0242 ENOG4106K80 I33_0244 ENOG4106DDH Sporulation-specific SASP protein I33_0246 ENOG4108HWY Beta-lactamase I33_0247 ENOG4107E6A Cytochrome p-450 I33_0249 ENOG4107QTZ amino acid I33_0251 ENOG4107VXM glycerophosphoryl diester phosphodiesterase I33_0252 ENOG4105CXY transporter I33_0254 ENOG410645S MarR family Transcriptional regulator I33_0255 ENOG4105DCM major facilitator superfamily I33_0260 ENOG410631K Membrane I33_0261 ENOG4106AXJ AraC family transcriptional regulator I33_0262 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR I33_0263 ENOG4108TCS Glutamyl endopeptidase I33_0265 ENOG4108WC5 Alpha Beta Hydrolase Fold protein I33_0266 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase I33_0267 ENOG4107ZTW SNARE associated Golgi I33_0271 ENOG4105C72 UPF0176 protein I33_0273 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane I33_0274 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) I33_0275 ENOG4108X79 transcriptional regulator I33_0278 ENOG4105CM2 brancheD-chain amino acid aminotransferase I33_0279 ENOG4108IQI permease I33_0280 ENOG4108J5H Homocysteine s-methyltransferase I33_0283 ENOG4105CSV Glutaminase I33_0286 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase I33_0287 ENOG4105C26 Dehydrogenase I33_0288 ENOG4105DJB Major Facilitator Superfamily I33_0289 ENOG4105EQX glucarate dehydratase I33_0290 ENOG41073TP transcriptional regulator I33_0291 ENOG4105CTX dehydratase I33_0295 ENOG4106UX7 integral membrane protein I33_0301 ENOG4105MUA Resistance protein I33_0303 ENOG4105DGI Alkaline phosphatase I33_0304 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) I33_0305 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) I33_0306 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) I33_0307 ENOG4107EPV Aminotransferase class V I33_0308 ENOG4105C0R drug resistance transporter emrb qaca subfamily I33_0309 ENOG4105J7D transcriptional regulator I33_0310 ENOG4107RB3 L-asparaginase I33_0311 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold I33_0313 ENOG41060AI SEC-C motif I33_0315 ENOG4107Y7X LytTR I33_0316 ENOG4108IUW ABC transporter I33_0317 ENOG4108SDH ABC, transporter I33_0318 ENOG4107SET aldo keto reductase I33_0324 ENOG4105H9W Short-chain dehydrogenase reductase Sdr I33_0326 ENOG4105DSE periplasmic solute binding protein I33_0327 ENOG4105DIK (ABC) transporter I33_0329 ENOG4105DEN Luciferase family I33_0330 ENOG4108N0M stress protein I33_0331 ENOG4106FN3 tellurium resistance protein I33_0332 ENOG4106FN3 tellurium resistance protein I33_0333 ENOG4107TS3 membrane protein, TerC I33_0334 ENOG4108TTB tellurium resistance protein I33_0336 ENOG41079KZ Major Facilitator Superfamily I33_0337 ENOG4107XZQ multidrug resistance protein I33_0338 ENOG4108A65 Transcriptional regulator I33_0339 ENOG4108IJ7 Glycine betaine I33_0340 ENOG4107SQ8 Glycine betaine I33_0349 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) I33_0356 ENOG4105EIG urea carboxylase-associated protein 1 I33_0357 ENOG4107RA1 nh(3)-dependent nad( ) synthetase I33_0358 ENOG4105I1F Resistance protein I33_0360 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) I33_0361 ENOG41089UC methyltransferase, type 11 I33_0362 ENOG4105C5Q Transcriptional regulator I33_0363 ENOG4105I82 acetyl xylan esterase I33_0364 ENOG410756H nucleotidyltransferase I33_0366 ENOG4105C26 Dehydrogenase I33_0367 ENOG4105CK7 Sodium proline symporter I33_0368 ENOG4107YHD transcriptional regulator I33_0370 ENOG4108PJD permease I33_0371 ENOG4105U6C Alpha beta hydrolase fold protein I33_0373 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) I33_0374 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit I33_0375 ENOG4108IFG nitrite reductase, (NAD(P)H) I33_0376 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) I33_0380 ENOG4105S7A ErfK ybiS ycfS ynhG family protein I33_0383 ENOG4105CKI cobalamin synthesis protein I33_0384 ENOG4105E5Q amino acid AbC transporter I33_0385 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein I33_0387 ENOG4105HHM rdd domain containing protein I33_0389 ENOG4105K56 Transcriptional regulator I33_0392 ENOG4105CS2 ec 3.2.1.21 I33_0395 ENOG4105C8Q Methyl-accepting chemotaxis I33_0396 ENOG41080HJ 6-phospho 3-hexuloisomerase I33_0397 ENOG4108VA3 3-hexulose-6-phosphate synthase I33_0398 ENOG4105KVH Transcriptional regulator I33_0407 ENOG4105SX7 Transporter I33_0409 ENOG4105W8Z 4'-phosphopantetheinyl transferase I33_0411 ENOG4105CDA abc transporter atp-binding protein I33_0412 ENOG4105DRP amino acid AbC transporter I33_0414 ENOG4106P55 Transcriptional regulator I33_0415 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase I33_0416 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) I33_0417 ENOG41069ZX I33_0418 ENOG41069ZX I33_0420 ENOG4105DUX Transporter I33_0423 ENOG4105E1K spore germination protein I33_0427 ENOG4107WD8 ABC transporter, permease I33_0428 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I33_0429 ENOG4105BZU Histidine kinase I33_0434 ENOG4105CFH Aspartokinase I33_0436 ENOG4105DHS permease protein I33_0437 ENOG4105CM4 permease protein I33_0438 ENOG4108IPW abc transporter atp-binding protein I33_0442 ENOG4105R8C Transcriptional regulator I33_0443 ENOG4108DBC nitroreductase I33_0444 ENOG41067V3 Antibiotic biosynthesis monooxygenase I33_0445 ENOG4105YVS arsR family transcriptional regulator I33_0447 ENOG4108JPW Aminotransferase I33_0448 ENOG4105C26 Dehydrogenase I33_0450 ENOG4105H9W Short-chain dehydrogenase reductase Sdr I33_0451 ENOG4105KTB nuclear export factor GLE1 I33_0452 ENOG4108T5E Copper resistance protein I33_0453 ENOG4108ZYE Transcriptional regulator I33_0455 ENOG4105DQ6 Transposase I33_0461 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) I33_0462 ENOG4108ZX0 Signal peptidase I I33_0466 ENOG4105E7W lamb ycsf family protein I33_0467 ENOG4105C5A transporter I33_0468 ENOG4105CFM UPF0317 protein I33_0469 ENOG4105P4J Allophanate hydrolase, subunit 1 I33_0471 ENOG4107258 Transcriptional regulator I33_0472 ENOG4105XJB lipolytic protein G-D-S-L family I33_0474 ENOG41061CK Antibiotic biosynthesis monooxygenase I33_0476 ENOG4107RVG penicillin-binding protein I33_0477 ENOG4107QM2 Aldo Keto reductase I33_0478 ENOG4105ETD TRANSCRIPTIONal I33_0481 ENOG4105HMZ Methyltransferase I33_0482 ENOG4105CYX Short-chain dehydrogenase reductase Sdr I33_0485 ENOG410606W general stress protein I33_0487 ENOG4105VCH membrane I33_0489 ENOG4105C9U ATP-dependent DNA helicase RecQ I33_0492 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) I33_0493 ENOG4107R8N Glycosyl transferase, family 2 I33_0495 ENOG4105C0X amino acid I33_0500 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) I33_0502 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) I33_0503 ENOG4105EU9 I33_0504 ENOG4105QVS general stress protein I33_0505 ENOG41082W1 Cupin 2, conserved barrel domain protein I33_0508 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit I33_0509 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism I33_0510 ENOG4108MRH transcriptional regulatory protein I33_0511 ENOG4107QJT sodium dicarboxylate symporter I33_0512 ENOG4106F5Q Membrane I33_0514 ENOG4105CJ1 ABC, transporter I33_0517 ENOG4105FDT acyl-CoA dehydrogenase I33_0521 ENOG4105SZ6 Thioredoxin I33_0522 ENOG4105CPF Cell wall formation (By similarity) I33_0523 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) I33_0524 ENOG4105C1J atp-dependent rna helicase I33_0525 ENOG410905X membrane-flanked domain protein I33_0526 ENOG4105CKV Membrane I33_0528 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) I33_0530 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) I33_0532 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) I33_0533 ENOG4107MMM Anti-sigma-factor antagonist I33_0534 ENOG4105FUA antagonist I33_0535 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase I33_0536 ENOG4107SGM protein serine threonine phosphatase I33_0537 ENOG4105WN5 stage II sporulation protein I33_0538 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) I33_0540 ENOG41064BQ Phosphatase I33_0543 ENOG4105M5P UPF0310 protein I33_0544 ENOG4105RV9 Transcriptional regulator I33_0555 ENOG4105DEN Luciferase family I33_0556 ENOG4105DEN Luciferase family I33_0557 ENOG4105DEN Luciferase family I33_0559 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein I33_0560 ENOG4108HH4 Major Facilitator Superfamily I33_0561 ENOG4106ANW SMI1_KNR4 I33_0563 ENOG4106BHF I33_0566 ENOG4105VZ8 Transcriptional regulator I33_0567 ENOG4105ECK Fatty Acid Desaturase I33_0568 ENOG4105VEQ Cold shock protein I33_0569 ENOG4108VJ1 Transcriptional regulator (CarD family I33_0571 ENOG4105DJ2 Major Facilitator Superfamily I33_0573 ENOG4108MCI Transcriptional regulator, ARAC family I33_0574 ENOG4108UZ3 Transporter I33_0575 ENOG41086D8 Transcriptional regulator I33_0578 ENOG4105DXI Major Facilitator superfamily I33_0580 ENOG4105CZ9 Domain of unknown function (DU1801) I33_0581 ENOG4105GIG I33_0583 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I33_0585 ENOG4107RSM transcriptional regulator I33_0586 ENOG4105C9Q fumarate hydratase class II I33_0588 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein I33_0591 ENOG4105T38 integral membrane protein I33_0592 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family I33_0593 ENOG4108ZMQ domain protein I33_0594 ENOG4105MJ9 esterase I33_0595 ENOG4107Z6X Transcriptional regulator I33_0597 ENOG41082YX Transcriptional regulator, arsr family I33_0598 ENOG4107R5R arsenical pump membrane protein I33_0599 ENOG4108UXE Protein tyrosine phosphatase I33_0600 ENOG4105Z7P Acetyltransferase (GNAT) family I33_0601 ENOG4108KGH TRANSCRIPTIONal I33_0602 ENOG4108ZJ4 polysaccharide deacetylase I33_0604 ENOG4105US7 Histidine kinase I33_0605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I33_0606 ENOG4107Y9U Membrane I33_0609 ENOG4108SQ9 flavin reductase domain protein, FMN-binding I33_0610 ENOG4108ZHR arsR family transcriptional regulator I33_0611 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) I33_0614 ENOG4105ENE Histidine kinase I33_0615 ENOG4108VB1 regulatoR I33_0616 ENOG4105EYF MMPL domain protein I33_0617 ENOG4108UQV Membrane I33_0618 ENOG4108Z5V transcriptional regulator, merr family I33_0619 ENOG41076HS cation diffusion facilitator family transporter I33_0620 ENOG4108TVJ Nitroreductase I33_0621 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase I33_0622 ENOG4108VGI doxx family I33_0624 ENOG4105XXY Thioredoxin I33_0631 ENOG410900G Protein of unknown function (DUF421) I33_0632 ENOG4108QY0 Membrane I33_0636 ENOG4105PF9 Transcriptional regulator I33_0639 ENOG4105WQG acetyltransferase I33_0641 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) I33_0642 ENOG4105ETE Transcriptional regulator (LacI family I33_0643 ENOG4105C54 Major Facilitator superfamily I33_0644 ENOG4107TRE AP endonuclease, family 2 I33_0646 ENOG4105C85 amino acid I33_0649 ENOG41062A4 Transcriptional regulator I33_0650 ENOG4105EYF MMPL domain protein I33_0651 ENOG4108TVJ Nitroreductase I33_0652 ENOG4105FS7 Transcriptional regulator I33_0654 ENOG4105C2C drug resistance transporter, Bcr CflA I33_0656 ENOG4105DRR Transcriptional regulator, GntR family I33_0657 ENOG4105VRS hydrolase family 18 I33_0661 ENOG4105G6Z alkaline phosphatase I33_0662 ENOG4108ZMX Domain of unknown function (DU1801) I33_0664 ENOG4108YM7 Gcn5-related n-acetyltransferase I33_0665 ENOG4107TVP HD domain protein I33_0667 ENOG41090UD (LipO)protein I33_0668 ENOG4105F27 Major Facilitator I33_0669 ENOG4105VZJ PTS System I33_0670 ENOG4105VCP PTS System I33_0671 ENOG4105CK1 PTS System I33_0672 ENOG4105CS2 ec 3.2.1.21 I33_0673 ENOG4108TZY GntR Family Transcriptional Regulator I33_0674 ENOG4105EVU fructokinase I33_0675 ENOG4105DG6 mannose-6-phosphate isomerase I33_0676 ENOG4105D3P Mannan endo-1,4-beta-mannosidase I33_0685 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) I33_0686 ENOG4105K8N protein family UPF0079, ATPase I33_0687 ENOG41072GX Peptidase M22 Glycoprotease I33_0688 ENOG410801F ribosomal-protein-alanine acetyltransferase I33_0689 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) I33_0690 ENOG4105C5H ABC transporter I33_0691 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) I33_0692 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) I33_0693 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) I33_0694 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) I33_0696 ENOG4108TYN CAAX amino terminal protease family protein I33_0697 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) I33_0698 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) I33_0700 ENOG4105PGZ NB-ARC domain I33_0702 ENOG4105CPQ Dehydrogenase I33_0703 ENOG4105CT4 transporter I33_0705 ENOG4108ZMR Ion transport 2 domain-containing protein I33_0706 ENOG4107QNK )-transporter I33_0711 ENOG4107YUH hydrolase I33_0714 ENOG4105C85 amino acid I33_0716 ENOG4105C7R Atpase associated with various cellular activities aaa_3 I33_0723 ENOG4105C7N Xanthine uracil vitamin C permease I33_0729 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) I33_0730 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit I33_0731 ENOG4105C83 adenylosuccinate lyase I33_0732 ENOG4105C8V SAICAR synthetase I33_0733 ENOG4105VR9 phosphoribosylformylglycinamidine synthase I33_0734 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I I33_0735 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii I33_0737 ENOG4105CXB phosphoribosylaminoimidazole synthetase I33_0738 ENOG4108V3E phosphoribosylglycinamide formyltransferase I33_0739 ENOG4105DC1 bifunctional purine biosynthesis protein purh I33_0740 ENOG4105C12 Phosphoribosylglycinamide synthetase I33_0742 ENOG4105DVH amino acid I33_0745 ENOG4108R5T secreted protein I33_0746 ENOG4105KGF protein, YerC YecD I33_0747 ENOG4105CBC glutamate synthase I33_0748 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) I33_0749 ENOG4105C4R Atp-dependent dna helicase I33_0750 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) I33_0753 ENOG4105CRN Aminoglycoside phosphotransferase I33_0754 ENOG4105KT7 mgtC SapB transporter I33_0755 ENOG4105CK7 Sodium proline symporter I33_0756 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) I33_0757 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) I33_0758 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) I33_0759 ENOG4108IG5 Transcriptional regulator I33_0761 ENOG4105CBD Diacylglycerol kinase I33_0762 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) I33_0764 ENOG4105CVR type I restriction-modification system I33_0766 ENOG4105DZR Type I site-specific deoxyribonuclease I33_0774 ENOG4105CDY transcriptional regulatory protein I33_0777 ENOG4105M4P Tetr family transcriptional regulator I33_0778 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein I33_0779 ENOG4107S9F NmrA family I33_0782 ENOG4105WEF catalase I33_0783 ENOG4105M18 -acetyltransferase I33_0786 ENOG4105C2F Histidine kinase I33_0787 ENOG4105EQD regulatoR I33_0788 ENOG410769Z extracellular solute-binding protein family 1 I33_0789 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component I33_0790 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component I33_0791 ENOG4105F5H Glycosyl Hydrolase Family 88 I33_0792 ENOG41075H3 AraC family transcriptional regulator I33_0793 ENOG4107TDE lipolytic protein G-D-S-L family I33_0796 ENOG4105CX8 fg-gap repeat protein I33_0797 ENOG4105CX8 fg-gap repeat protein I33_0798 ENOG4107TDE lipolytic protein G-D-S-L family I33_0800 ENOG4105EKC I33_0801 ENOG4105E0S extracellular solute-binding protein family 1 I33_0803 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component I33_0804 ENOG4105F8D glycoside hydrolase family 4 I33_0805 ENOG4105H67 Protein of unknown function (DUF421) I33_0806 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) I33_0807 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily I33_0811 ENOG4106I4J membrane I33_0812 ENOG4108PCN EamA-like transporter family I33_0813 ENOG41082F9 transcriptional regulator I33_0814 ENOG41061H0 Monooxygenase I33_0815 ENOG4108R1P I33_0816 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) I33_0818 ENOG4105E0M Sulfatase I33_0819 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase I33_0821 ENOG41090R9 glycosyltransferase I33_0823 ENOG41090R9 glycosyltransferase I33_0824 ENOG4105EU0 Major facilitator Superfamily I33_0827 ENOG4105CUB amino acid I33_0828 ENOG4105C26 Dehydrogenase I33_0829 ENOG4105FKZ Methyl-accepting chemotaxis I33_0830 ENOG4105C5H ABC transporter I33_0832 ENOG4107SWG transcriptional regulator MERR family I33_0833 ENOG4105DXB Major Facilitator superfamily I33_0835 ENOG4105C5H ABC transporter I33_0836 ENOG4105FDU atp-dependent rna helicase I33_0838 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein I33_0840 ENOG4105E0A ABC, transporter I33_0841 ENOG4108U1V ABC transporter, permease I33_0842 ENOG4105DQ5 transport system permease protein I33_0843 ENOG4108HUF Transporter I33_0847 ENOG4108J20 pectate lyase I33_0848 ENOG4107QPK )-transporter I33_0853 ENOG4106WTF Glycosyl transferase, family 2 I33_0854 ENOG4108SHN Glycosyl transferase, family 2 I33_0856 ENOG4108MRH transcriptional regulatory protein I33_0862 ENOG410855V Acylphosphatase I33_0863 ENOG4108RPX mosc domain containing protein I33_0867 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) I33_0872 ENOG4105GEU Spore germination protein I33_0874 ENOG4108Q5U germination protein, ger(x)c family I33_0875 ENOG4105E1K spore germination protein I33_0876 ENOG4105C5Y PTS System I33_0877 ENOG4105CG3 alpha amylase, catalytic region I33_0878 ENOG4107414 GntR family transcriptional regulator I33_0879 ENOG4108RCM Nitroreductase I33_0880 ENOG4105CGH 5'-nucleotidase I33_0882 ENOG4107RKG DJ-1/PfpI family I33_0886 ENOG4105KJF protein tyrosine phosphatase I33_0888 ENOG4107U9T Pfam:Ribonuclease_BN I33_0889 ENOG4108ISG Major Facilitator I33_0891 ENOG4105UPD Calcium Proton I33_0893 ENOG4105D8X mechanosensitive ion channel I33_0897 ENOG4106KE4 Dehydrogenase I33_0898 ENOG4105D7N magnesium and cobalt transport protein CorA I33_0900 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) I33_0905 ENOG4107RUY (E1 component), alpha subunit I33_0907 ENOG4107QKR Dehydrogenase I33_0910 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family I33_0911 ENOG41069DP small acid-soluble spore protein I33_0912 ENOG4105KK4 UPF0060 membrane protein I33_0920 ENOG4107EV6 Inherit from COG: YD repeat protein I33_0923 ENOG4105F8D glycoside hydrolase family 4 I33_0924 ENOG4108Q3X Transcriptional regulator I33_0925 ENOG4105CI1 PTS System I33_0926 ENOG4105BZ1 (ABC) transporter I33_0927 ENOG4105BZ1 (ABC) transporter I33_0929 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase I33_0930 ENOG4105ID8 Transcriptional regulator, ARAC family I33_0931 ENOG4107QP6 Xylose isomerase domain protein TIM barrel I33_0932 ENOG4105CIB oxidoreductase Domain protein I33_0933 ENOG4105BZU Histidine kinase I33_0934 ENOG4105WH1 Two component transcriptional regulator luxr family I33_0936 ENOG4105CJ1 ABC, transporter I33_0937 ENOG41090VJ ABC-2 type transporter I33_0938 ENOG4108KYE ABC-2 type transporter I33_0940 ENOG4105U3E Transcriptional regulator I33_0942 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold I33_0943 ENOG4105H93 Acyltransferase family I33_0944 ENOG4108YYS metal-dependent hydrolase (By similarity) I33_0945 ENOG4105C0R drug resistance transporter emrb qaca subfamily I33_0946 ENOG410834F Transcriptional regulator I33_0948 ENOG4108MES Periplasmic binding protein I33_0949 ENOG4105DQ5 transport system permease protein I33_0950 ENOG4108IHU transport system permease protein I33_0951 ENOG4105JAB phenazine biosynthesis protein, phzf family I33_0952 ENOG4107Y03 Nitroreductase I33_0955 ENOG4105ECP epimerase I33_0958 ENOG4105F27 Major Facilitator I33_0962 ENOG4106AKJ I33_0963 ENOG4105CKK Glycosyl transferase, family 2 I33_0964 ENOG4105EJV Membrane I33_0965 ENOG41067AE Membrane-bound metal-dependent hydrolase I33_0966 ENOG4105CEN a g-specific adenine glycosylase I33_0967 ENOG4106BXE I33_0968 ENOG4105CAN Short-chain dehydrogenase reductase Sdr I33_0971 ENOG4105EVI UPF0374 protein I33_0972 ENOG4105BZ1 (ABC) transporter I33_0973 ENOG4107NBY Membrane I33_0975 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen I33_0976 ENOG4105G5W regulator Fur family I33_0999 ENOG4108N23 SpoOM-related protein I33_1002 ENOG4105EC3 peptidase S51, dipeptidase E I33_1003 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) I33_1006 ENOG4105E2Y ABC, transporter I33_1007 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein I33_1008 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component I33_1009 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) I33_1011 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) I33_1012 ENOG4107D63 I33_1013 ENOG4105VZ8 Transcriptional regulator I33_1016 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) I33_1018 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) I33_1024 ENOG4105CYN Serine protein kinase I33_1025 ENOG4106AKX UPF0229 protein I33_1026 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes I33_1027 ENOG4105CW7 secretion protein, HlyD family I33_1028 ENOG4105C0R drug resistance transporter emrb qaca subfamily I33_1029 ENOG4105CS1 NAD(P)H quinone oxidoreductase I33_1033 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family I33_1034 ENOG4105CZV ABC transporter I33_1035 ENOG4105CJ1 ABC, transporter I33_1036 ENOG4108TU7 Inherit from COG: (ABC) transporter I33_1037 ENOG4105VEQ Cold shock protein I33_1039 ENOG4105BZU Histidine kinase I33_1047 ENOG4108YBP pseudouridine synthase I33_1049 ENOG41080XP Cbs domain I33_1050 ENOG4107YBY Hydrolase I33_1051 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase I33_1053 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) I33_1054 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator I33_1056 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) I33_1057 ENOG4105C6V Glycerol-3-phosphate dehydrogenase I33_1059 ENOG4105BZU Histidine kinase I33_1060 ENOG4105WH1 Two component transcriptional regulator luxr family I33_1067 ENOG4105ED1 spovr family I33_1068 ENOG4105G6Z alkaline phosphatase I33_1072 ENOG4105BZN citrate synthase I33_1073 ENOG4105CYX Short-chain dehydrogenase reductase Sdr I33_1074 ENOG4105CUB amino acid I33_1075 ENOG4105C8J )-transporter I33_1076 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family I33_1079 ENOG4105J37 I33_1080 ENOG4108AEY RNA polymerase sigma factor I33_1081 ENOG4108FN7 Aldo keto reductase I33_1082 ENOG4105F6E Acyl-transferase I33_1083 ENOG4105C37 (CBS) domain I33_1085 ENOG4105CHM Aminotransferase I33_1087 ENOG4105C37 (CBS) domain I33_1089 ENOG4105WMR Protein CrcB homolog I33_1090 ENOG4108QXE glycerophosphoryl diester phosphodiesterase I33_1092 ENOG4105D64 Mechanosensitive ion channel I33_1093 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) I33_1094 ENOG4107VMI polysaccharide deacetylase I33_1095 ENOG4105F0I Aminotransferase I33_1099 ENOG4105BZ1 (ABC) transporter I33_1100 ENOG4105BZ1 (ABC) transporter I33_1105 ENOG410839P I33_1107 ENOG4106MP8 UPF0754 membrane protein I33_1108 ENOG4105WZB UPF0342 protein I33_1109 ENOG4105F1N DNA alkylation repair I33_1111 ENOG4105D4P Coproporphyrinogen iii oxidase I33_1112 ENOG4107S91 Sodium hydrogen exchanger I33_1113 ENOG4105NCW Trka-c domain protein I33_1115 ENOG4105CGU Enoyl-CoA hydratase I33_1117 ENOG4108IUX (ABC) transporter I33_1118 ENOG4105RHA ABC transporter, permease I33_1120 ENOG4107VRP DNA repair exonuclease I33_1121 ENOG4106D4I domain protein I33_1122 ENOG4105EQI Metal Dependent Phosphohydrolase I33_1124 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) I33_1132 ENOG4105NBU tryptophan transport protein I33_1133 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) I33_1134 ENOG4105K59 histidine triad (HIT) protein I33_1141 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation I33_1142 ENOG4105BZ4 penicillin-binding protein I33_1143 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) I33_1145 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) I33_1146 ENOG4105C1Q protoporphyrinogen oxidase I33_1148 ENOG4105ECB domain protein I33_1150 ENOG41090T1 Membrane I33_1152 ENOG4105DER m42 family I33_1155 ENOG4106AXD I33_1156 ENOG4108RQ5 Beta-lactamase domain-containing protein I33_1157 ENOG4105DF9 Lipoate-protein, ligase I33_1159 ENOG4105CEY Amp-dependent synthetase and ligase I33_1161 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 I33_1162 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin I33_1164 ENOG4105KD7 acetyltransferase I33_1166 ENOG4108HUF Transporter I33_1167 ENOG4107TB6 phosphoglycerate mutase I33_1169 ENOG4107F3J Amp-dependent synthetase and ligase I33_1170 ENOG4107ZYJ bioY protein I33_1171 ENOG4106YBV Methyl-accepting chemotaxis I33_1175 ENOG4105XVF Competence transcription factor I33_1176 ENOG4105CYX Short-chain dehydrogenase reductase Sdr I33_1177 ENOG4105X3H Excalibur domain protein I33_1178 ENOG4105E1V na solute symporter I33_1179 ENOG4106CAD Protein of unknown function (DUF3311) I33_1180 ENOG41060YP I33_1183 ENOG4107SCK Monooxygenase I33_1184 ENOG4108INS Transcriptional regulator I33_1188 ENOG4105TRI Hydrolase I33_1191 ENOG4108KK1 membrane protein AbrB duplication I33_1192 ENOG4106K7D Major facilitator family transporter I33_1193 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) I33_1194 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding I33_1198 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation I33_1200 ENOG4105EYH Exonuclease I33_1211 ENOG4105ERH Fumarylacetoacetate hydrolase I33_1213 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin I33_1215 ENOG4105CAQ asparagine synthetase I33_1217 ENOG4105UQX Mate efflux family protein I33_1218 ENOG4106HBX Transcriptional Regulator AraC Family I33_1219 ENOG4105ETE Transcriptional regulator (LacI family I33_1220 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) I33_1221 ENOG4105SF0 DinB family I33_1222 ENOG4108ZUB Lysine exporter protein (Lyse ygga) I33_1223 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family I33_1224 ENOG4105MYW Pentapeptide repeat protein I33_1225 ENOG4107S9D Alpha beta hydrolase I33_1226 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) I33_1227 ENOG4107RIQ Sulfate adenylate transferase I33_1228 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) I33_1229 ENOG4108N5B 2-phosphosulfolactate phosphatase I33_1230 ENOG41061P3 phosphosulfolactate synthase I33_1232 ENOG4105DIA mandelate racemase muconate lactonizing I33_1233 ENOG4107RCC Major Facilitator Superfamily I33_1234 ENOG4108SZE gCN5-related N-acetyltransferase I33_1235 ENOG4105MA6 gCN5-related N-acetyltransferase I33_1237 ENOG4108VPT UPF0234 protein I33_1238 ENOG4105QNR S1 RNA binding domain protein I33_1239 ENOG410751J I33_1240 ENOG4105EPR degv family I33_1241 ENOG4107AYK membrAne I33_1243 ENOG41073B9 I33_1245 ENOG4108KP7 hydrolase I33_1246 ENOG4108MXZ Esterase I33_1247 ENOG4105VG1 fes assembly suf system protein I33_1249 ENOG4105IQ5 FAD linked oxidase domain protein I33_1251 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase I33_1254 ENOG4105C8Y Acetylornithine aminotransferase I33_1255 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain I33_1257 ENOG4105DBV ornithine carbamoyltransferase I33_1262 ENOG4107RMD Basic membrane lipoprotein I33_1265 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) I33_1266 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) I33_1268 ENOG4105C3U ABC transporter I33_1269 ENOG4108JQ7 (ABC) transporter I33_1272 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component I33_1274 ENOG4105C31 Tryptophanyl-tRNA synthetase I33_1275 ENOG4108J59 Extracellular solute-binding protein, family 5 I33_1276 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component I33_1277 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component I33_1279 ENOG4108JQ7 (ABC) transporter I33_1282 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) I33_1283 ENOG4108ZCF integral membrane protein I33_1284 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis I33_1287 ENOG4105DPN Oligoendopeptidase f I33_1289 ENOG4105T58 Dithiol-disulfide isomerase I33_1290 ENOG4108Z18 K06886 hemoglobin I33_1291 ENOG4105E4C Lytic transglycosylase catalytic I33_1292 ENOG4105MIX Adenylate cyclase I33_1295 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) I33_1296 ENOG4105EMS pseudouridine synthase I33_1299 ENOG4105ETU transcriptional activator (TenA I33_1300 ENOG4108VEU Thiamine monophosphate synthase I33_1303 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) I33_1304 ENOG4105D06 uba thif-type nad fad binding protein I33_1305 ENOG4105DWF phosphomethylpyrimidine kinase I33_1306 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH I33_1307 ENOG4107A88 I33_1319 ENOG4105ENA helicase I33_1322 ENOG4108ZMI UPF0477 protein I33_1324 ENOG4105C28 cystathionine I33_1325 ENOG4105C28 cystathionine I33_1326 ENOG4105D9U N-acetyltransferase I33_1329 ENOG4105D0M Protease HtpX homolog I33_1330 ENOG4105JHY Membrane I33_1338 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase I33_1350 ENOG4105DM4 PTS System I33_1351 ENOG4105DG6 mannose-6-phosphate isomerase I33_1352 ENOG4105G7B Protein of unknown function (DUF2992) I33_1353 ENOG4105VMI -acetyltransferase I33_1355 ENOG4108Z66 YbaK ebsC protein I33_1359 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) I33_1361 ENOG4108ZJ4 polysaccharide deacetylase I33_1362 ENOG4107CUJ Protein of unknown function (DUF2690) I33_1368 ENOG4108IEG Formate dehydrogenase Alpha subunit I33_1373 ENOG4106A3M Cytochrome p-450 I33_1374 ENOG41087PP glycosyltransferase MGT family I33_1376 ENOG4105EXQ uroporphyrinogen iii synthase hem4 I33_1377 ENOG4105C4B ABC transporter, permease I33_1378 ENOG4108IXI (ABC) transporter I33_1381 ENOG4105Q95 Cupin 2, conserved barrel domain protein I33_1385 ENOG4105D2H Uronic isomerase I33_1386 ENOG4105CT4 transporter I33_1387 ENOG4105DG4 malate L-lactate dehydrogenase I33_1388 ENOG4105CPQ Dehydrogenase I33_1389 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) I33_1390 ENOG4105DMW Dehydrogenase reductase I33_1391 ENOG4108I5G Major Facilitator superfamily I33_1392 ENOG4107KJX Transcriptional regulator I33_1393 ENOG4107QZW Altronate oxidoreductase I33_1394 ENOG4105CTX dehydratase I33_1395 ENOG4107TSN permease I33_1397 ENOG4105JD4 ATPase yjob I33_1400 ENOG41068K0 YCII-related domain I33_1401 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase I33_1402 ENOG4105KWG Pfam:DUF1696 I33_1403 ENOG4105K7W phage-related replication protein I33_1404 ENOG4105WEF catalase I33_1405 ENOG410635T phage-like element pbsx protein I33_1414 ENOG4108TFU terminase (Small subunit) I33_1415 ENOG4105IG6 Phage terminase, large subunit I33_1416 ENOG4108MDF Phage Portal Protein I33_1421 ENOG41060SN I33_1424 ENOG4105PQS phage protein I33_1425 ENOG4105FR7 XkdM protein, phage-like element PBSX I33_1426 ENOG4105MTC XkdN-like protein I33_1427 ENOG4108FKH Transglycosylase SLT domain I33_1428 ENOG4108WZM domain protein I33_1429 ENOG4105X7F I33_1431 ENOG4105MFU Protein of unknown function (DUF2634) I33_1432 ENOG41066EA baseplate J family protein I33_1433 ENOG410906S phage-like element pbsx protein xkdt I33_1435 ENOG41068G1 I33_1441 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase I33_1445 ENOG4105CJ3 phosphate transporter I33_1446 ENOG4107GRR phosphate transport regulator I33_1447 ENOG4107R7I amino acid I33_1450 ENOG4105EDW glycosyl transferase, family 39 I33_1451 ENOG4105CKK Glycosyl transferase, family 2 I33_1452 ENOG4105C0H protease I33_1454 ENOG4108ME1 Peptidase M55 D-aminopeptidase I33_1455 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component I33_1456 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component I33_1457 ENOG4105C3U ABC transporter I33_1460 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A I33_1461 ENOG4105DTQ mandelate racemase muconate lactonizing I33_1462 ENOG4107SN7 NLP P60 protein I33_1463 ENOG4108JQ7 (ABC) transporter I33_1464 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) I33_1465 ENOG4107TUM Amidinotransferase I33_1466 ENOG4108S4H thioesterase Superfamily protein I33_1467 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) I33_1471 ENOG4108428 Inherit from COG: -acetyltransferase I33_1473 ENOG41080TC multidrug resistance protein I33_1474 ENOG4105CIY formyltetrahydrofolate deformylase I33_1475 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) I33_1478 ENOG4105K56 Transcriptional regulator I33_1479 ENOG4108ZHJ Organic hydroperoxide resistance protein I33_1481 ENOG4107Y2X deaminase I33_1483 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) I33_1485 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin I33_1488 ENOG4108W7F transporter, permease I33_1489 ENOG4108JJB ABC transporter I33_1490 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein I33_1491 ENOG4108X43 YKOF domain protein I33_1492 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I33_1495 ENOG4106849 propeptide, pepSY amd peptidase M4 I33_1498 ENOG4105CJW magnesium transporter I33_1499 ENOG4105V75 Transcriptional regulator I33_1508 ENOG4105DQE DNA ligase I33_1509 ENOG4105FDF Could be involved in DNA repair (By similarity) I33_1510 ENOG4105BZU Histidine kinase I33_1512 ENOG4107T5V SNARE associated Golgi I33_1513 ENOG4107TS3 membrane protein, TerC I33_1514 ENOG4108WZW RNA polymerase sigma I33_1516 ENOG410681C small acid-soluble spore protein I33_1518 ENOG4105D0M Protease HtpX homolog I33_1522 ENOG4108TGC Acyltransferase I33_1523 ENOG4105BZU Histidine kinase I33_1524 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) I33_1526 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) I33_1527 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) I33_1528 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase I33_1530 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit I33_1531 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) I33_1532 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) I33_1533 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) I33_1537 ENOG4105BZU Histidine kinase I33_1538 ENOG41090MY MarR family Transcriptional regulator I33_1539 ENOG4105ER2 Ompa motb domain protein I33_1540 ENOG4105E14 MotA TolQ exbB proton channel I33_1542 ENOG4108K88 Membrane I33_1543 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) I33_1544 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase I33_1545 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) I33_1546 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) I33_1549 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr I33_1558 ENOG4105F0V Cell wall hydrolase I33_1561 ENOG4105C59 p-type ATPase I33_1563 ENOG4105DC7 peptidase M24 I33_1566 ENOG4105CID antiterminator I33_1568 ENOG4105KRI phosphocarrier protein (HPr I33_1569 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) I33_1571 ENOG4105F6S Spore photoproduct lyase I33_1573 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer I33_1574 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase I33_1575 ENOG4105K4I Scp-like extracellular I33_1577 ENOG4105BZU Histidine kinase I33_1578 ENOG4105CHM Aminotransferase I33_1580 ENOG4107R88 Chemotaxis protein (CheV) I33_1581 ENOG4105UIN I33_1583 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein I33_1585 ENOG4105K6S Short-chain dehydrogenase reductase Sdr I33_1586 ENOG4105EPM Diguanylate phosphodiesterase I33_1588 ENOG4107IN1 Protein of unknown function (DUF1797) I33_1589 ENOG4108XRC Protein of unknown function (DUF458) I33_1595 ENOG4105NQC Flavodoxin I33_1597 ENOG4105CH2 amidohydrolase I33_1599 ENOG4105D8X mechanosensitive ion channel I33_1600 ENOG4105D3R alkyl hydroperoxide reductase I33_1601 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen I33_1604 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) I33_1605 ENOG4105D06 uba thif-type nad fad binding protein I33_1606 ENOG4105CVM Molybdenum cofactor synthesis domain protein I33_1607 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein I33_1608 ENOG4108ZAF Molybdopterin I33_1609 ENOG41067WU Molybdopterin converting factor (Subunit 1) I33_1610 ENOG4105BZ1 (ABC) transporter I33_1611 ENOG4105BZ1 (ABC) transporter I33_1613 ENOG4107X8C Efflux transporter RND family MFP subunit I33_1614 ENOG4105C19 ABC transporter I33_1615 ENOG4107RBB ABC transporter, permease I33_1616 ENOG4105E98 transcriptional regulator DeoR family I33_1617 ENOG4105DE4 1-phosphofructokinase I33_1618 ENOG4105DM4 PTS System I33_1619 ENOG4105C3F Signal peptidase i I33_1621 ENOG4105C5H ABC transporter I33_1622 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) I33_1627 ENOG4105BZU Histidine kinase I33_1629 ENOG4107ZYR domain protein I33_1631 ENOG4105CN5 Metallo-Beta-Lactamase I33_1634 ENOG4108X4Q Hydrolase I33_1635 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) I33_1639 ENOG4105CPP Dehydrogenase, E1 component I33_1640 ENOG4105C7S Dehydrogenase I33_1641 ENOG4107QN2 dihydrolipoyl dehydrogenase I33_1644 ENOG4105CXN decarboxylase I33_1645 ENOG4105WBI UPF0223 protein I33_1649 ENOG4105ECY inositol monophosphatase I33_1651 ENOG4105JQZ Methyltransferase I33_1659 ENOG4105CI3 gtp-binding protein typa I33_1660 ENOG4105QA2 I33_1663 ENOG4108IAB Phoh family I33_1665 ENOG4105CSV Glutaminase I33_1666 ENOG4105ZPI UPF0358 protein I33_1667 ENOG4105CNI cell division protein FtsW I33_1668 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) I33_1671 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) I33_1674 ENOG4105BZ9 Cytochrome C oxidase, subunit I I33_1675 ENOG4105CCU oxidase (Subunit III) I33_1676 ENOG41064X9 cytochrome C oxidase subunit IV I33_1679 ENOG41080XQ Signal transduction protein with cbs domains I33_1680 ENOG4106UY4 Inherit from COG: Scp-like extracellular I33_1684 ENOG4105WUC UPF0298 protein I33_1686 ENOG4106H78 methyltransferase I33_1687 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) I33_1688 ENOG4105H20 Sporulation integral membrane protein YlbJ I33_1689 ENOG4105D78 K07001 NTE family protein I33_1690 ENOG41063PX domain protein I33_1691 ENOG4105CDE UPF0348 protein I33_1693 ENOG4105KNH Nucleic acid-binding protein I33_1699 ENOG4108V6E Cell division protein mraZ I33_1700 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) I33_1702 ENOG4105CJN penicillin-binding protein I33_1703 ENOG4105CJN penicillin-binding protein I33_1704 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) I33_1705 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) I33_1706 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) I33_1707 ENOG4105CNI cell division protein FtsW I33_1708 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) I33_1709 ENOG4105D4A Cell wall formation (By similarity) I33_1710 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) I33_1711 ENOG4108R2U division initiation protein I33_1713 ENOG4105K67 small basic protein I33_1714 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) I33_1715 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) I33_1717 ENOG4105FFI sigma-e processing peptidase spoiiga I33_1718 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I33_1720 ENOG4105DKW ABC transporter I33_1722 ENOG4105WR5 sporulation protein, YlmC YmxH family I33_1723 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase I33_1724 ENOG4105DFA alanine racemase domain protein I33_1725 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) I33_1726 ENOG41067XK integral membrane protein I33_1727 ENOG4105DBK s4 domain protein I33_1732 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) I33_1733 ENOG4105C34 Pseudouridine synthase I33_1734 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) I33_1736 ENOG4105CXT aspartate transcarbamylase I33_1738 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain I33_1739 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain I33_1740 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) I33_1741 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) I33_1742 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) I33_1743 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) I33_1744 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) I33_1746 ENOG4107S4M Sulfate adenylate transferase I33_1747 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) I33_1748 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) I33_1749 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein I33_1750 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein I33_1751 ENOG4105F23 Fibronectin-binding protein I33_1753 ENOG4105DSJ YicC domain protein I33_1754 ENOG4105KC4 UPF0296 protein I33_1755 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) I33_1757 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase I33_1758 ENOG4105C25 Primosomal protein n' I33_1759 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) I33_1760 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) I33_1761 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B I33_1762 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs I33_1763 ENOG4108ZF3 Phosphatase I33_1764 ENOG4105D9P serine threonine protein kinase I33_1765 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) I33_1766 ENOG4105DJV ribulose-phosphate 3-epimerase I33_1767 ENOG4105FJ0 thiamine I33_1768 ENOG4105VB9 50S ribosomal protein l28 I33_1769 ENOG4108ZAA Alkaline-shock protein I33_1770 ENOG4105DP4 dak2 domain fusion protein ylov I33_1772 ENOG4105EJQ L-serine dehydratase I33_1773 ENOG4105CB5 ATP-dependent DNA helicase recG I33_1774 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) I33_1776 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase I33_1777 ENOG4105CHR reductase I33_1778 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) I33_1779 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) I33_1780 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) I33_1781 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) I33_1783 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) I33_1785 ENOG4105K5M 30s ribosomal protein S16 I33_1786 ENOG4108BW8 UPF0109 protein I33_1788 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) I33_1789 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) I33_1790 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) I33_1791 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) I33_1792 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) I33_1794 ENOG4105VM1 flagellar I33_1795 ENOG4105CMV Succinyl-CoA synthetase subunit beta I33_1796 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha I33_1797 ENOG4105C79 DNA protecting protein DprA I33_1798 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) I33_1799 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) I33_1800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) I33_1801 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) I33_1802 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) I33_1804 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) I33_1805 ENOG4108ZC9 flagellar basal-body rod protein flgc I33_1806 ENOG4105VQ0 flagellar hook-basal body complex protein fliE I33_1807 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) I33_1808 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) I33_1811 ENOG4106YF4 Flagellar biosynthesis chaperone I33_1813 ENOG410696Y Flagellar hook-length control protein I33_1814 ENOG410822I Flagellar hook capping protein I33_1815 ENOG4108JQA flagellar I33_1816 ENOG41068WV flagellar FlbD family protein I33_1818 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) I33_1819 ENOG4105DD5 Flagellar motor switch protein I33_1820 ENOG4107YTP response regulator receiver protein I33_1822 ENOG4105CN7 Flagellar biosynthetic protein FliP I33_1823 ENOG4105VS8 Flagellar biosynthetic protein fliq I33_1824 ENOG4105D19 Role in flagellar biosynthesis (By similarity) I33_1825 ENOG4105D00 flagellar biosynthetic protein flhB I33_1826 ENOG4105D7B Flagellar biosynthesis protein flha I33_1827 ENOG4105FZW flagellar biosynthesis regulator FlhF I33_1829 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) I33_1830 ENOG4105CBS Chea signal transduction histidine kinase I33_1831 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis I33_1834 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I33_1836 ENOG4105CE9 30S ribosomal protein S2 I33_1837 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) I33_1839 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) I33_1840 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) I33_1841 ENOG4105KNE Phosphatidate cytidylyltransferase I33_1843 ENOG4105DZP Membrane-associated zinc metalloprotease I33_1844 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) I33_1845 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) I33_1846 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) I33_1847 ENOG4105CHV Transcription elongation factor NusA I33_1848 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination I33_1849 ENOG4105VHM ribosomal protein I33_1850 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) I33_1851 ENOG4105W7A Protein of unknown function (DUF503) I33_1852 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) I33_1853 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) I33_1854 ENOG4105DTN riboflavin biosynthesis protein ribF I33_1855 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) I33_1857 ENOG4105C1V Peptidase, M16 I33_1860 ENOG4105E35 Dipicolinate synthase subunit A I33_1861 ENOG4108S0H Dipicolinic acid synthetase, b subunit I33_1862 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) I33_1864 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) I33_1866 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit I33_1868 ENOG4105CNU cell division protein FtsK I33_1869 ENOG4105FDP GntR family transcriptional regulator I33_1874 ENOG4108RKS Short-chain dehydrogenase reductase Sdr I33_1875 ENOG4105XZV Protein of unknown function (DUF3243) I33_1878 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase I33_1879 ENOG4105CEV competence damage-inducible protein I33_1881 ENOG4108A04 Beta-lactamase I33_1882 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) I33_1883 ENOG4105D48 metallophosphoesterase I33_1884 ENOG4105MCT stage V sporulation protein S I33_1886 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) I33_1887 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) I33_1890 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) I33_1891 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) I33_1893 ENOG4105IIP Membrane I33_1894 ENOG4105W1N transcriptional regulator I33_1895 ENOG4108151 Beta-lactamase domain protein I33_1896 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase I33_1899 ENOG4107QKG PfaD family I33_1900 ENOG41062T2 Acyl carrier protein I33_1901 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase I33_1902 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase I33_1903 ENOG4108MGH Enoyl-CoA hydratase I33_1904 ENOG4108KQ6 Enoyl-CoA hydratase I33_1905 ENOG4105C0W non-ribosomal peptide synthetase I33_1906 ENOG4107SQU synthase I33_1908 ENOG4105C0W non-ribosomal peptide synthetase I33_1910 ENOG4106A3M Cytochrome p-450 I33_1914 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin I33_1917 ENOG4105K7W phage-related replication protein I33_1918 ENOG4108X3M OsmC Ohr family protein I33_1919 ENOG410814C multidrug resistance protein I33_1924 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) I33_1925 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) I33_1928 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) I33_1929 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) I33_1930 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) I33_1931 ENOG4105U6W MutT NUDIX family protein I33_1932 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase I33_1935 ENOG4106F1P AAA ATPase, central domain protein I33_1936 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) I33_1937 ENOG4105CXI aluminum resistance protein I33_1938 ENOG4105KV4 Transcriptional regulator I33_1939 ENOG4105C5F glutamine synthetase I33_1946 ENOG4106ANW SMI1_KNR4 I33_1953 ENOG4107AUC I33_1962 ENOG4105CT4 transporter I33_1963 ENOG4105DSG hydrolase family 43 I33_1964 ENOG4105E2R ROK family I33_1965 ENOG4105C93 Xylose Isomerase I33_1966 ENOG4105CMG Carbohydrate kinase I33_1967 ENOG4107Y9E nuclease I33_1968 ENOG4105C54 Major Facilitator superfamily I33_1969 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) I33_1972 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) I33_1975 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) I33_1987 ENOG4108Q8B Spore germination protein I33_1988 ENOG4108NHD germination protein I33_1992 ENOG4105FVX I33_1994 ENOG4105K7W phage-related replication protein I33_1996 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) I33_1997 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) I33_1999 ENOG4108SVB resolvase I33_2000 ENOG4105VPS UPF0291 protein I33_2001 ENOG4105CV1 Transketolase (EC 2.2.1.1) I33_2005 ENOG4107QIV Cytochrome c biogenesis protein I33_2010 ENOG4107DZX Small, acid-soluble spore protein P I33_2012 ENOG4108I0Z Aconitate hydratase I33_2013 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen I33_2016 ENOG41067CD Small, acid-soluble spore protein Tlp I33_2018 ENOG4105MI2 I33_2019 ENOG4105W8X HesB YadR YfhF-family protein I33_2020 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) I33_2022 ENOG4105K4P CoA-binding domain protein I33_2024 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) I33_2031 ENOG4107QWR cellulase (EC 3.2.1.4) I33_2033 ENOG4108MYR Secreted protein I33_2034 ENOG4107SYN Glycosyl hydrolases family 43 I33_2036 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase I33_2037 ENOG4107T5V SNARE associated Golgi I33_2039 ENOG4107QX3 carboxylase I33_2040 ENOG4105E39 Enoyl-CoA hydratase I33_2041 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase I33_2042 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit I33_2043 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase I33_2044 ENOG4105CEY Amp-dependent synthetase and ligase I33_2045 ENOG4105C1G acyl-Coa dehydrogenase I33_2047 ENOG4108RZE Tetr family transcriptional regulator I33_2049 ENOG4105F32 YngK protein I33_2050 ENOG4106U2H Protein of unknown function (DUF1360) I33_2052 ENOG4105CEY Amp-dependent synthetase and ligase I33_2053 ENOG4105C0W non-ribosomal peptide synthetase I33_2055 ENOG4105C0W non-ribosomal peptide synthetase I33_2056 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family I33_2057 ENOG4108N2V aldose 1-epimerase I33_2058 ENOG4107QJQ Mate efflux family protein I33_2063 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I33_2064 ENOG4105SKE transcriptional Regulator LysR family I33_2065 ENOG4105CB2 alcohol dehydrogenase I33_2066 ENOG4105BZ8 glutamate synthase I33_2067 ENOG4105CBC glutamate synthase I33_2068 ENOG4105C5Q Transcriptional regulator I33_2069 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) I33_2070 ENOG4105II7 pyrroline-5-carboxylate reductase I33_2075 ENOG4108UB7 I33_2076 ENOG41068WN I33_2077 ENOG4105IE8 Alpha-ketoglutarate permease I33_2078 ENOG4107U6E carbohydrate kinase FGGY I33_2079 ENOG4108M3J Dehydrogenase I33_2080 ENOG4108J2R molybdopterin oxidoreductase I33_2082 ENOG4105CIB oxidoreductase Domain protein I33_2083 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) I33_2085 ENOG4105ETE Transcriptional regulator (LacI family I33_2089 ENOG4105EC8 Methyl-accepting chemotaxis I33_2091 ENOG4108YQE rare lipoprotein a I33_2092 ENOG4105XPP Protein of unknown function (DUF1275) I33_2093 ENOG4108NR7 pectate lyase I33_2094 ENOG4108RAV Conserved protein I33_2097 ENOG4105F0F Oxalate decarboxylase I33_2101 ENOG41073R8 VanW family I33_2103 ENOG4105VMP Transcriptional regulator I33_2104 ENOG4105NX3 Membrane I33_2106 ENOG4108Q5Y Membrane I33_2108 ENOG4108V4B ThiJ pfpI I33_2109 ENOG4108J4B Beta-lactamase I33_2112 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) I33_2113 ENOG4107T94 Endo-14-beta-xylanase I33_2115 ENOG4105YB8 TM2 domain containing protein I33_2116 ENOG4108IMY Transcriptional regulator I33_2121 ENOG4108RAV Conserved protein I33_2123 ENOG4108RAV Conserved protein I33_2124 ENOG4105F04 LysR family Transcriptional regulator I33_2132 ENOG410780I phosphoprotein phosphatase activity I33_2133 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) I33_2134 ENOG4106BHF I33_2138 ENOG4108Z7R Chaperone CsaA I33_2139 ENOG4105FTV AraC Family Transcriptional Regulator I33_2140 ENOG4108HJF gCN5-related N-acetyltransferase I33_2142 ENOG4108W8B Beta-lactamase domain protein I33_2144 ENOG4105D29 Helix-turn-helix type 11 domain protein I33_2146 ENOG4105KTU Transcriptional regulator, arsr family I33_2148 ENOG4108SJC Membrane I33_2152 ENOG4105ECK Fatty Acid Desaturase I33_2153 ENOG4108ZGX Histidine kinase I33_2154 ENOG4108S01 response regulator I33_2156 ENOG41069ER domain protein I33_2157 ENOG4105C9U ATP-dependent DNA helicase RecQ I33_2160 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) I33_2161 ENOG4105SCY DNAK suppressor I33_2169 ENOG4105C26 Dehydrogenase I33_2170 ENOG4105EWU Squalene--hopene cyclase I33_2171 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) I33_2172 ENOG4105C8J )-transporter I33_2173 ENOG4105C09 Bile acid I33_2174 ENOG4105C7S Dehydrogenase I33_2176 ENOG4107T89 von Willebrand factor, type A I33_2177 ENOG4105GMT ATPase associated with various cellular activities aaa_5 I33_2179 ENOG4105K4H Nlp p60 protein I33_2180 ENOG41087PP glycosyltransferase MGT family I33_2182 ENOG4107QMU Mate efflux family protein I33_2183 ENOG4106SCS STAS domain I33_2187 ENOG4105FR1 rard protein I33_2190 ENOG4105C6Z Gluconate I33_2191 ENOG41090U3 tautomerase I33_2195 ENOG4105FBA Phospholipase Carboxylesterase I33_2198 ENOG4105E1V na solute symporter I33_2202 ENOG4108VXD carboxy-peptidase I33_2203 ENOG4105D3A purine nucleoside phosphorylase DeoD-type I33_2205 ENOG4106Z5R I33_2206 ENOG410841Q phosphoesterase PA-phosphatase related protein I33_2212 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein I33_2213 ENOG4108TSC N-acetyltransferase I33_2214 ENOG4107S4Y M20 DapE family protein YgeY I33_2217 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) I33_2224 ENOG4107T32 3-phytase (EC 3.1.3.8) I33_2225 ENOG4105C5E polysaccharide biosynthesis protein I33_2226 ENOG4105E0X reductase I33_2227 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) I33_2231 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) I33_2232 ENOG41090WU lipolytic protein G-D-S-L family I33_2233 ENOG4108KF3 Electron transport protein SCO1 SenC I33_2235 ENOG4105C7B Threonine dehydratase I33_2237 ENOG4108UT2 hemolysin iii I33_2239 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) I33_2242 ENOG4107YX5 Pfam:DUF548 I33_2243 ENOG4108Y6J UPF0403 protein I33_2244 ENOG4105C01 Dihydroxy-acid dehydratase I33_2248 ENOG4108V06 Glutathione peroxidase I33_2249 ENOG4105CVG Homoserine O-transsuccinylase I33_2258 ENOG41081VK Ribonuclease I33_2263 ENOG410890F Dynamin family I33_2265 ENOG41065KQ synthase I33_2266 ENOG4105C2W permease I33_2267 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) I33_2268 ENOG4105CTD carboxy-peptidase I33_2269 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) I33_2270 ENOG4108UHU Aldolase I33_2271 ENOG4105D7K pfkb domain protein I33_2272 ENOG4108M60 Transcriptional regulator I33_2274 ENOG4105CHR reductase I33_2275 ENOG4105DVT helicase I33_2277 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) I33_2279 ENOG4108UKS UPF0398 protein I33_2281 ENOG4107X2U Inherit from COG: Exonuclease-like protein I33_2282 ENOG4108I5C dEAD DEAH box helicase I33_2292 ENOG4105BZ4 penicillin-binding protein I33_2294 ENOG4105CSM endonuclease III I33_2296 ENOG4105C5S asparaginyl-tRNA synthetase I33_2297 ENOG4105CHM Aminotransferase I33_2299 ENOG4105YAC I33_2300 ENOG4105DVT helicase I33_2301 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) I33_2302 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) I33_2303 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) I33_2304 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase I33_2305 ENOG4105DJ0 Poly(A) Polymerase I33_2306 ENOG4105CPK Glycosyl transferase (Group 1 I33_2307 ENOG4105FJR Lmbe family I33_2308 ENOG4108Z5K methylglyoxal synthase I33_2309 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) I33_2310 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase I33_2311 ENOG4108JYZ YitT family I33_2315 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) I33_2319 ENOG41068YB TPR repeat-containing protein I33_2320 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase I33_2324 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) I33_2325 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase I33_2327 ENOG4108I0Q anthranilate phosphoribosyltransferase I33_2328 ENOG4105CRQ synthase (Component I) I33_2329 ENOG4105KHN chorismate mutase I33_2330 ENOG4105D49 3-dehydroquinate synthase I33_2331 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase I33_2332 ENOG4105BZU Histidine kinase I33_2333 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) I33_2334 ENOG4105EAH synthase I33_2335 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) I33_2336 ENOG4105XXQ heptaprenyl diphosphate synthase component I I33_2338 ENOG4105EUJ GTP cyclohydrolase i I33_2339 ENOG4105K70 DNA-binding protein I33_2343 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase I33_2344 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) I33_2345 ENOG41065D1 I33_2346 ENOG4105S2F I33_2349 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) I33_2350 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) I33_2351 ENOG4105CAT Cytidine monophosphate kinase I33_2354 ENOG4105MSI germination protein ypeb I33_2357 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) I33_2359 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase I33_2363 ENOG4107RGJ metallophosphoesterase I33_2366 ENOG4105I7S Abortive infection protein I33_2367 ENOG4105C9U ATP-dependent DNA helicase RecQ I33_2368 ENOG4105T7X I33_2370 ENOG4108SAX Membrane I33_2372 ENOG4108JQ1 Dehydrogenase I33_2373 ENOG4105FF2 Type I DHQase I33_2376 ENOG4105BZU Histidine kinase I33_2377 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I33_2378 ENOG4105CRE cytochrome C I33_2379 ENOG4107TWT Cytochrome c biogenesis protein I33_2381 ENOG4105FE9 pseudouridine synthase I33_2383 ENOG4108JIC nucleoside recognition domain protein I33_2384 ENOG4105DZ1 carboxypeptidase I33_2386 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) I33_2387 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) I33_2390 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) I33_2391 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) I33_2392 ENOG4108R6K riboflavin synthase, subunit alpha I33_2393 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) I33_2396 ENOG4105C3F Signal peptidase i I33_2398 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) I33_2402 ENOG4107ZE5 PPIases accelerate the folding of proteins I33_2405 ENOG4107ZE5 PPIases accelerate the folding of proteins I33_2406 ENOG4105PTM secreted protein I33_2407 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) I33_2411 ENOG4105CZ3 stage V sporulation protein ad I33_2412 ENOG41090VF Stage v sporulation protein ac I33_2415 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I33_2416 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) I33_2417 ENOG41082AN stage II sporulation protein I33_2421 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) I33_2422 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) I33_2424 ENOG4105I3K Ferric uptake regulator, Fur family I33_2425 ENOG4105MZ9 stage II sporulation protein m I33_2429 ENOG4105DFD Na H antiporter I33_2430 ENOG4108IJ0 Aspartate ammonia-lyase I33_2431 ENOG4105HDK L-asparaginase I33_2432 ENOG4108IMY Transcriptional regulator I33_2434 ENOG4108YZ4 nudix hydrolase I33_2436 ENOG4105CPC Aldo Keto reductase I33_2441 ENOG4106HZJ I33_2442 ENOG4105RHY Pfam:UPF0157 I33_2443 ENOG4105KAC Antibiotic biosynthesis monooxygenase I33_2444 ENOG4108XET gCN5-related N-acetyltransferase I33_2446 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) I33_2448 ENOG4105E5W Transporter I33_2450 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase I33_2453 ENOG4108IXY short-chain dehydrogenase reductase I33_2454 ENOG41069FQ Metallo-beta-lactamase superfamily I33_2455 ENOG4105II7 pyrroline-5-carboxylate reductase I33_2457 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I33_2459 ENOG410861F 50S ribosomal protein L33 I33_2460 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) I33_2461 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase I33_2463 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) I33_2464 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) I33_2466 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) I33_2467 ENOG4108NA0 Uncharacterized conserved protein (COG2071) I33_2468 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) I33_2469 ENOG4108HNZ carboxyl transferase I33_2470 ENOG4108ZVT methylmalonyl-coA epimerase I33_2471 ENOG4108VZI ErfK ybiS ycfS ynhG family protein I33_2472 ENOG4108QEG Membrane I33_2473 ENOG4105CDA abc transporter atp-binding protein I33_2474 ENOG4105E5Q amino acid AbC transporter I33_2475 ENOG4108HW3 (ABC) transporter I33_2477 ENOG4108Y6J UPF0403 protein I33_2478 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) I33_2481 ENOG4105C7S Dehydrogenase I33_2482 ENOG4105CPP Dehydrogenase, E1 component I33_2485 ENOG4105CKM Branched-chain carboxylic acid kinase I33_2486 ENOG4107RDP Dehydrogenase I33_2488 ENOG4108JUB Transcriptional regulator I33_2489 ENOG4106CCJ Protein of unknown function (DUF2627) I33_2490 ENOG4105CR4 methylisocitrate lyase I33_2491 ENOG4105DXD 2-methylcitrate dehydratase I33_2493 ENOG4105C1G acyl-Coa dehydrogenase I33_2494 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase I33_2496 ENOG4108QXE glycerophosphoryl diester phosphodiesterase I33_2497 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase I33_2500 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase I33_2502 ENOG4107QQR Sporulation I33_2503 ENOG4105S1Z Stage IV sporulation protein B I33_2504 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) I33_2505 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) I33_2506 ENOG4105DX0 Hemolysin A I33_2508 ENOG4105CTB Polyprenyl synthetase I33_2509 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) I33_2510 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) I33_2511 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) I33_2512 ENOG4105M7K Involved in the transcription termination process (By similarity) I33_2513 ENOG4108ZSR alkaline shock protein I33_2514 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase I33_2518 ENOG410644B Stage III sporulation protein af I33_2520 ENOG4105KQ4 Stage iii sporulation protein ad I33_2521 ENOG4108CQH stage III sporulation protein AC I33_2522 ENOG4105KR5 Stage iii sporulation protein I33_2523 ENOG4105CD2 stage iii sporulation protein aa I33_2525 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) I33_2526 ENOG4105DC7 peptidase M24 I33_2527 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) I33_2529 ENOG4105CBJ Metal-dependent enzyme I33_2532 ENOG4105KST dependent repressor I33_2533 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) I33_2534 ENOG4105WZW rhodanese family I33_2535 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor I33_2536 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor I33_2537 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) I33_2538 ENOG4105C0D helicase I33_2541 ENOG4108IMY Transcriptional regulator I33_2543 ENOG4105VFR signal peptidase I33_2556 ENOG4105C37 (CBS) domain I33_2561 ENOG4105C5X domain protein I33_2566 ENOG4105E0M Sulfatase I33_2569 ENOG4107ZXI Rhomboid family I33_2571 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase I33_2577 ENOG41068DG YceG-like family I33_2578 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) I33_2579 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) I33_2580 ENOG4105E2Z phosphate ABC transporter (Permease I33_2581 ENOG4105C8U phosphate abc transporter I33_2582 ENOG4105CVA phosphate I33_2583 ENOG4107RF6 penicillin-binding protein I33_2585 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) I33_2586 ENOG4105SXS Protein of unknown function (DUF456) I33_2589 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) I33_2590 ENOG41063Y9 I33_2591 ENOG4108U5J '-nucleotidase I33_2592 ENOG4105N80 Ferric uptake regulator, Fur family I33_2593 ENOG4108JYZ YitT family I33_2594 ENOG41069ZM Protein of unknown function (DUF2624) I33_2595 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) I33_2598 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) I33_2599 ENOG4105EGD dinuclear metal center protein, YbgI family I33_2603 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I33_2604 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) I33_2605 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 I33_2607 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) I33_2609 ENOG4105C38 Glycyl-tRNA synthetase beta subunit I33_2610 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit I33_2611 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) I33_2613 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) I33_2614 ENOG4105KG3 cytidine deaminase I33_2615 ENOG4107YR5 Diacylglycerol kinase I33_2616 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) I33_2617 ENOG4105CTJ Metal Dependent Phosphohydrolase I33_2618 ENOG4105C9A Phoh family I33_2620 ENOG41068P3 sporulation protein YqfC I33_2622 ENOG4105DI5 UPF0365 protein I33_2623 ENOG4105F7J membrane-bound serine protease I33_2624 ENOG4105KTH gatB Yqey I33_2627 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) I33_2628 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) I33_2629 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) I33_2631 ENOG4105CFG Acts as a chaperone (By similarity) I33_2632 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ I33_2633 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) I33_2634 ENOG4105CSA Coproporphyrinogen iii oxidase I33_2635 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) I33_2637 ENOG4108ZRV stage ii sporulation protein p I33_2638 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) I33_2639 ENOG41082YS Binds directly to 16S ribosomal RNA I33_2640 ENOG4105TQK DNA polymerase iii, delta' subunit I33_2643 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 I33_2645 ENOG4108UK2 deaminase I33_2646 ENOG4105KQC Competence protein I33_2648 ENOG4108D32 Methyltransferase I33_2650 ENOG4108WF2 Metal Dependent Phosphohydrolase I33_2651 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) I33_2652 ENOG410812S Rna-binding protein I33_2653 ENOG4105E2X shikimate dehydrogenase I33_2654 ENOG4105CQW ribosome biogenesis GTPase YqeH I33_2655 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase I33_2659 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase I33_2660 ENOG41080BT SNARE associated Golgi I33_2663 ENOG4105WFK nuclease I33_2664 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I33_2667 ENOG4106ANW SMI1_KNR4 I33_2668 ENOG4105ST3 Transcriptional regulator I33_2669 ENOG4105ENX hydrolase I33_2671 ENOG4105EMU Dehydrogenase I33_2672 ENOG4108RWP Major Facilitator Superfamily protein I33_2675 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase I33_2697 ENOG41090E6 transcriptional regulator MERR family I33_2700 ENOG4105C37 (CBS) domain I33_2706 ENOG41067XF inhibitor I33_2712 ENOG41075D4 Aminoglycoside 6-adenylyltransferase I33_2713 ENOG4105EA8 2-Nitropropane dioxygenase I33_2715 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) I33_2716 ENOG4105CK5 oxidoreductase I33_2717 ENOG4108DBC nitroreductase I33_2724 ENOG4105UNS Pfam:DUF419 I33_2727 ENOG4108MEK Metal-binding protein YodA I33_2728 ENOG410904A RNA polymerase I33_2729 ENOG4105CPC Aldo Keto reductase I33_2730 ENOG41083Q9 chitosanase I33_2731 ENOG4105X5K response regulator receiver protein I33_2732 ENOG4108VQT Alpha beta hydrolase fold protein I33_2733 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein I33_2734 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein I33_2735 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase I33_2737 ENOG4105PGS Spore coat protein I33_2738 ENOG4105E2A Dehydrogenase I33_2741 ENOG4105VUF Transcriptional regulator I33_2742 ENOG4105DQ4 alcohol dehydrogenase I33_2743 ENOG4108Z0Z intracellular protease Pfpi family I33_2744 ENOG4108HKT sucrose-6-phosphate hydrolase I33_2745 ENOG4105F3R pts system mannose fructose sorbose family iid I33_2746 ENOG4105ETZ PTS System I33_2747 ENOG4108IQ3 PTS system I33_2748 ENOG4105YHU PTS system I33_2749 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family I33_2750 ENOG4105C85 amino acid I33_2751 ENOG4105N14 lysine exporter protein LysE YggA I33_2752 ENOG4108NGU Transcriptional regulator I33_2753 ENOG4105JVQ RNA Polymerase I33_2754 ENOG4108P49 AntiSigma factor I33_2755 ENOG4105EXC Acyl-transferase I33_2756 ENOG4105WDR I33_2757 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) I33_2758 ENOG41082JN Transcriptional regulator I33_2762 ENOG4105TMB Formate nitrite transporter I33_2763 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) I33_2764 ENOG4108JB9 formate dehydrogenase I33_2767 ENOG4105C28 cystathionine I33_2770 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) I33_2773 ENOG4107XRG penicillin-binding protein I33_2774 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) I33_2775 ENOG4105DBI uridine monophosphokinase I33_2776 ENOG4105CFP Peptidase U32 I33_2777 ENOG4105XYU peptidase (U32 family) I33_2778 ENOG4108VQJ O-methyltransferase I33_2779 ENOG4105HHA aminodeoxychorismate lyase I33_2780 ENOG4105VPH UPF0473 protein I33_2781 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) I33_2782 ENOG4105VBH UPF0297 protein I33_2783 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) I33_2784 ENOG4105C02 permease I33_2786 ENOG4105CDA abc transporter atp-binding protein I33_2787 ENOG4105CT1 (ABC) transporter I33_2788 ENOG4105EAD ABC transporter I33_2789 ENOG4105DRP amino acid AbC transporter I33_2791 ENOG41060CR I33_2793 ENOG4105C7H Helicase, RecD TraA family I33_2795 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) I33_2796 ENOG4105C3J Cysteine desulfurase I33_2798 ENOG4105D1H recombination factor protein RarA I33_2799 ENOG4105CUZ uba thif-type nad fad binding protein I33_2801 ENOG4105C9M aspartyl-trna synthetase I33_2802 ENOG4105CUT histidyl-tRNA synthetase I33_2804 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase I33_2806 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) I33_2807 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) I33_2808 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) I33_2809 ENOG41067VP Protein of unknown function (DUF1049) I33_2810 ENOG4105NCW Trka-c domain protein I33_2811 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) I33_2813 ENOG4105CKP Polysaccharide Biosynthesis Protein I33_2814 ENOG4108QG2 Membrane I33_2815 ENOG4105NAP I33_2816 ENOG4105VIE preprotein translocase, subunit YajC I33_2817 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) I33_2818 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) I33_2819 ENOG41061AI Protein of unknown function (DUF2905) I33_2820 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) I33_2821 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) I33_2823 ENOG4105IE8 Alpha-ketoglutarate permease I33_2824 ENOG4105CK5 oxidoreductase I33_2829 ENOG4105BZG amino acid carrier protein I33_2830 ENOG4105CDY transcriptional regulatory protein I33_2832 ENOG4106678 morphogenetic protein associated with SpoVID I33_2833 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) I33_2834 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase I33_2835 ENOG4108IYU L-aspartate oxidase I33_2838 ENOG4105CQC Prephenate dehydratase I33_2839 ENOG41090I5 UPF0735 ACT domain-containing protein I33_2840 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control I33_2843 ENOG4105K46 50S ribosomal protein l27 I33_2844 ENOG4105X36 (ribosomal) protein I33_2845 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) I33_2848 ENOG4107QMS site-determining protein I33_2849 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) I33_2850 ENOG4105YHC Rod shape-determining protein MreD I33_2851 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) I33_2852 ENOG4105DFF Rod shape-determining protein mreb I33_2853 ENOG4105W5Q DNA repair protein (RadC I33_2854 ENOG4108Z03 MAF-like protein I33_2856 ENOG4106A3R peptidase I33_2857 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase I33_2858 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) I33_2860 ENOG4106AR7 Spore coat protein I33_2861 ENOG41068KH stage VI sporulation protein D I33_2862 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase I33_2863 ENOG4105D52 delta-aminolevulinic acid dehydratase I33_2865 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) I33_2867 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) I33_2869 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) I33_2870 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) I33_2871 ENOG4108IUQ atp-dependent protease I33_2872 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) I33_2873 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation I33_2876 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) I33_2877 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) I33_2878 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) I33_2879 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) I33_2880 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase I33_2881 ENOG4108ZP8 Acetolactate synthase small subunit I33_2882 ENOG4105C7K acetolactate synthase I33_2884 ENOG4105I4A GCN5-related N-acetyltransferase I33_2886 ENOG4107KM7 Heat induced stress protein YflT I33_2888 ENOG4105M59 Phosphodiesterase, mj0936 family I33_2889 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) I33_2890 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) I33_2891 ENOG4108XJQ germination protein I33_2892 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) I33_2893 ENOG41067TZ transcriptional regulator, MarR family I33_2895 ENOG4105PFC Transcriptional regulator I33_2897 ENOG4105E33 succinate dehydrogenase I33_2899 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit I33_2901 ENOG4105CFH Aspartokinase I33_2902 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) I33_2903 ENOG4105K63 Thioredoxin I33_2906 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) I33_2907 ENOG4105C10 Electron transfer flavoprotein I33_2908 ENOG4105BZJ Electron transfer flavoprotein I33_2909 ENOG41060WC Enoyl-CoA hydratase I33_2910 ENOG4107Z3H Transcriptional regulator, TetR family I33_2911 ENOG4105CEY Amp-dependent synthetase and ligase I33_2913 ENOG4105C98 muts2 protein I33_2914 ENOG4105DCG PHP domain protein I33_2917 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) I33_2918 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) I33_2919 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) I33_2921 ENOG4108RWN rrna methyltransferase I33_2922 ENOG41067MF small acid-soluble spore protein I33_2924 ENOG4105CQB FAD linked oxidase domain protein I33_2925 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) I33_2928 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) I33_2929 ENOG4105DRS transport system, permease I33_2932 ENOG4108MDK Dehydrogenase I33_2934 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase I33_2935 ENOG4105EF1 ribulokinase I33_2937 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase I33_2938 ENOG4105CN9 Peptidase m42 family protein I33_2940 ENOG410696E Membrane I33_2941 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) I33_2942 ENOG4105VJV 50s ribosomal protein L35 I33_2943 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) I33_2945 ENOG41067MG lrgb family I33_2947 ENOG4105DY9 regulatoR I33_2948 ENOG4108HRK Histidine kinase I33_2949 ENOG4105U0R haloacid dehalogenase-like hydrolase I33_2950 ENOG4105C22 threonyL-tRNA synthetase I33_2956 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) I33_2958 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) I33_2959 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase I33_2960 ENOG4105KVH Transcriptional regulator I33_2961 ENOG4105F27 Major Facilitator I33_2962 ENOG4105CV8 reductase I33_2963 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) I33_2965 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) I33_2966 ENOG4105C2M dna polymerase I I33_2967 ENOG4105BZU Histidine kinase I33_2968 ENOG4105DPZ Two component transcriptional regulator (Winged helix family I33_2970 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) I33_2971 ENOG4108HMX isocitrate dehydrogenase (NADP) I33_2972 ENOG4105BZN citrate synthase I33_2974 ENOG4108REF Sporulation integral membrane protein ytvi I33_2975 ENOG4105FS0 cytoplasmic membrane protein I33_2976 ENOG4105CA9 Pyruvate kinase I33_2977 ENOG4105CTQ phosphohexokinase I33_2980 ENOG4108IEY Carboxyl transferase domain I33_2981 ENOG4105C6K Malic enzyme I33_2982 ENOG4105C0B DNA polymerase III (alpha subunit) I33_2983 ENOG4105VV2 I33_2985 ENOG4106EVM I33_2986 ENOG4105SFS phosphoesterase RecJ domain protein I33_2990 ENOG4105E8R UPF0173 metal-dependent hydrolase I33_2994 ENOG4105CH7 arginosuccinase I33_2995 ENOG4105CDH Citrulline--aspartate ligase I33_2996 ENOG4105EPU Molybdenum cofactor synthesis domain protein I33_2997 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) I33_3000 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) I33_3001 ENOG4105KBJ sporulation protein ytfj I33_3003 ENOG4105VK3 rdd domain containing protein I33_3004 ENOG4105D07 Signal peptide peptidase, SppA I33_3006 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) I33_3007 ENOG4105EFZ amidohydrolase I33_3008 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) I33_3015 ENOG4105U5Y Transcriptional regulator I33_3017 ENOG4105BZU Histidine kinase I33_3019 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) I33_3021 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) I33_3023 ENOG4105F1V Acetoin utilization protein I33_3024 ENOG4105W87 Cbs domain I33_3025 ENOG4105DGU Histone deacetylase I33_3026 ENOG4105ER2 Ompa motb domain protein I33_3027 ENOG4107R0U MotA TolQ exbB proton channel I33_3028 ENOG4105ETE Transcriptional regulator (LacI family I33_3029 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase I33_3033 ENOG4105DFU Cell wall formation (By similarity) I33_3036 ENOG4108VDD TRNA binding domain protein I33_3040 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ I33_3044 ENOG4105C6K Malic enzyme I33_3045 ENOG4105C8F Beta-lactamase domain protein I33_3046 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) I33_3048 ENOG4108V15 phosphotransferase enzyme family I33_3049 ENOG4108IUM Glycogen debranching enzyme I33_3052 ENOG4107F58 2'-5' rna ligase I33_3053 ENOG4105C6T cysteine synthase I33_3054 ENOG4107QSE Dipeptidase I33_3055 ENOG4105C7N Xanthine uracil vitamin C permease I33_3058 ENOG4105YW5 deoR family transcriptional regulator I33_3061 ENOG4105CBX hi0933 family I33_3062 ENOG4105C94 Transporter I33_3064 ENOG4105MU9 integral membrane protein I33_3065 ENOG4105DDC Oxidoreductase domain protein I33_3067 ENOG4105F5H Glycosyl Hydrolase Family 88 I33_3069 ENOG41075H3 AraC family transcriptional regulator I33_3071 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component I33_3073 ENOG4106A3M Cytochrome p-450 I33_3074 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) I33_3076 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) I33_3077 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) I33_3079 ENOG4105NTD Inherit from COG: Hydrolase I33_3082 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component I33_3083 ENOG4105I1K ABC transporter I33_3085 ENOG41085GJ domain protein I33_3086 ENOG4105C8T Leucyl-tRNA synthetase I33_3089 ENOG4105BZU Histidine kinase I33_3090 ENOG410605W Major Facilitator I33_3092 ENOG4106UBQ I33_3094 ENOG4105C19 ABC transporter I33_3095 ENOG4105EWM Histidine kinase I33_3097 ENOG4107R34 abc transporter permease protein I33_3098 ENOG4105C19 ABC transporter I33_3101 ENOG4105DVE abc transporter atp-binding protein I33_3102 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family I33_3105 ENOG4105N5T Radical SAM Protein I33_3108 ENOG4105E8V Alpha Beta Hydrolase Fold protein I33_3109 ENOG4108Z0R Transferase I33_3110 ENOG4105C85 amino acid I33_3111 ENOG4105CAQ asparagine synthetase I33_3112 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP I33_3113 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase I33_3116 ENOG4105D2X ABC transporter substrate-binding protein I33_3118 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component I33_3122 ENOG4108RMU ferritin dps family protein I33_3125 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) I33_3126 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) I33_3127 ENOG4108V2W Carbonate dehydratase I33_3132 ENOG4105CC5 ABC transporter I33_3133 ENOG4105CC5 ABC transporter I33_3134 ENOG4105DIK (ABC) transporter I33_3135 ENOG4105DSE periplasmic solute binding protein I33_3137 ENOG4105DTQ mandelate racemase muconate lactonizing I33_3138 ENOG4105CEY Amp-dependent synthetase and ligase I33_3139 ENOG4108IPT Naphthoate synthase I33_3140 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) I33_3141 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) I33_3142 ENOG4105E4F Isochorismate synthase I33_3147 ENOG4108IAJ Nad-dependent epimerase dehydratase I33_3148 ENOG4107SBE Glycosyl transferase (Group 1 I33_3151 ENOG4107SBE Glycosyl transferase (Group 1 I33_3152 ENOG4108KS4 Spore coat protein I33_3155 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) I33_3157 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) I33_3183 ENOG4105N67 Proton-coupled thiamine transporter YuaJ I33_3184 ENOG4105VRR gCN5-related N-acetyltransferase I33_3185 ENOG4105DZ6 Band 7 protein I33_3187 ENOG4106DF1 I33_3188 ENOG4108VNY MOSC domain protein I33_3189 ENOG4108JB8 alcohol dehydrogenase I33_3190 ENOG4105C26 Dehydrogenase I33_3191 ENOG4105TRT Transcriptional regulator I33_3194 ENOG4105CZN Potassium uptake protein I33_3195 ENOG4107I77 yiaA/B two helix domain I33_3196 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj I33_3201 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) I33_3203 ENOG4105EE0 oxidoreductase I33_3204 ENOG4105DKG l-rhamnose isomerase I33_3207 ENOG4105DET Rhamnulokinase I33_3208 ENOG4105E98 transcriptional regulator DeoR family I33_3210 ENOG4105C8Q Methyl-accepting chemotaxis I33_3211 ENOG4105C8Q Methyl-accepting chemotaxis I33_3212 ENOG4105C8Q Methyl-accepting chemotaxis I33_3213 ENOG4105C8Q Methyl-accepting chemotaxis I33_3217 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme I33_3219 ENOG4105C37 (CBS) domain I33_3222 ENOG4107PBV potassium channel I33_3223 ENOG4107PBV potassium channel I33_3226 ENOG4107QYV phosphohexose isomerase I33_3228 ENOG4107QW4 alcohol dehydrogenase I33_3229 ENOG4105WG9 Conserved Protein I33_3231 ENOG4105CHM Aminotransferase I33_3232 ENOG4108ZB6 transcriptional regulator AsnC family I33_3233 ENOG4108MUZ hydrolase I33_3235 ENOG4105C87 Aminotransferase class I and II I33_3236 ENOG4108HGU Histidine kinase I33_3237 ENOG4105Y38 Kinase-associated protein B I33_3241 ENOG4105BZ4 penicillin-binding protein I33_3242 ENOG4105KIR Thiol-disulfide oxidoreductase dcc I33_3245 ENOG4108MRH transcriptional regulatory protein I33_3246 ENOG4105DIH basic membrane I33_3247 ENOG4108JQ9 ABC transporter I33_3248 ENOG4105UIB (ABC) transporter I33_3252 ENOG4105D65 subunit l I33_3253 ENOG4105HC0 Na H antiporter I33_3254 ENOG4108ZE9 Monovalent cation H antiporter subunit C I33_3255 ENOG4108JPZ Monovalent cation H antiporter subunit D I33_3256 ENOG4105SC1 monovalent cation H antiporter subunit E I33_3258 ENOG4105KJM monovalent cation h antiporter subunit g I33_3259 ENOG4105KA0 thioesterase Superfamily protein I33_3261 ENOG4105BZU Histidine kinase I33_3266 ENOG4105D58 Diguanylate phosphodiesterase I33_3267 ENOG4105DAP Nicotinate phosphoribosyltransferase I33_3272 ENOG4105C02 permease I33_3276 ENOG410904N short-chain dehydrogenase reductase I33_3283 ENOG4108K8K Transcriptional regulator I33_3284 ENOG4105DCF alanine dehydrogenase I33_3286 ENOG4105WQT MbtH domain protein I33_3287 ENOG4105CEY Amp-dependent synthetase and ligase I33_3288 ENOG4105WQI isochorismatase I33_3289 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase I33_3290 ENOG4105E4F Isochorismate synthase I33_3291 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase I33_3292 ENOG4105NIV Esterase I33_3296 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) I33_3298 ENOG41069ER domain protein I33_3301 ENOG4105CEP NADH dehydrogenase I33_3303 ENOG4105CAY ferredoxin--nadp reductase I33_3309 ENOG4105CJ1 ABC, transporter I33_3314 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 I33_3315 ENOG4108YX9 iron--sulfur cluster insertion protein erpA I33_3318 ENOG4105ZKE UPF0349 protein I33_3321 ENOG41083MR nifu domain-containing protein I33_3322 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein I33_3323 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) I33_3324 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) I33_3325 ENOG4105D6E homoserine dehydrogenase I33_3328 ENOG4108W5N phosphatidylglycerophosphatase a I33_3329 ENOG4105D4U had-superfamily hydrolase, subfamily iia I33_3331 ENOG4105MMD transcriptional regulator I33_3332 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) I33_3333 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) I33_3334 ENOG4105FAA peptidase M23 I33_3335 ENOG4108YTE sporulation protein YunB I33_3336 ENOG4105KZD Domain of unknown function (DUF1805) I33_3337 ENOG4107R8B 5'-nucleotidase I33_3339 ENOG4105I3N Conserved Protein I33_3341 ENOG4105CD3 dihydroorotase I33_3342 ENOG4105G9B Transcriptional regulator I33_3345 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) I33_3346 ENOG4105VT2 5-hydroxyisourate hydrolase I33_3350 ENOG4107YV9 domain protein I33_3351 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding I33_3354 ENOG4105XRQ Xanthine dehydrogenase accessory factor I33_3355 ENOG4105C5R Aminotransferase I33_3358 ENOG4108K8S endonuclease I I33_3359 ENOG4108IJ9 (ABC) transporter I33_3360 ENOG4105FDP GntR family transcriptional regulator I33_3361 ENOG4108KPW sugar kinase I33_3362 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component I33_3363 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component I33_3364 ENOG4105XN3 extracellular solute-binding protein family 1 I33_3365 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine I33_3366 ENOG4105PKS Excinuclease abc c subunit domain protein I33_3367 ENOG4107VFR oxidoreductase I33_3370 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase I33_3371 ENOG4105DIW FeS assembly protein SUFB I33_3372 ENOG4108UNV SUF system FeS assembly protein, NifU family I33_3373 ENOG4105C9B Cysteine desulfurase I33_3374 ENOG4105JRK feS assembly protein SufD I33_3375 ENOG4105C3K feS assembly ATPase SufC I33_3380 ENOG4105D01 (LipO)protein I33_3381 ENOG4108UMI ABC transporter, permease I33_3382 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) I33_3388 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) I33_3389 ENOG41080E8 Transcriptional regulator, Spx MgsR family I33_3390 ENOG4105C1G acyl-Coa dehydrogenase I33_3391 ENOG4105CHU acetyl-coa acetyltransferase I33_3396 ENOG41067TZ transcriptional regulator, MarR family I33_3397 ENOG4105C0R drug resistance transporter emrb qaca subfamily I33_3398 ENOG4105MDS 4-oxalocrotonate tautomerase I33_3400 ENOG4105EGI Transcriptional regulator I33_3402 ENOG4105E0A ABC, transporter I33_3405 ENOG4105E1F short-chain dehydrogenase reductase I33_3406 ENOG4105HUF DNA protection during starvation protein I33_3407 ENOG4105C0H protease I33_3410 ENOG4105F3H Histidine kinase I33_3412 ENOG41067SE Tetr family transcriptional regulator I33_3413 ENOG4105C9Q fumarate hydratase class II I33_3418 ENOG4105WH1 Two component transcriptional regulator luxr family I33_3419 ENOG4105ENE Histidine kinase I33_3422 ENOG41087YS Phage shock protein A I33_3426 ENOG4108WBT adenosyltransferase I33_3427 ENOG4105E0A ABC, transporter I33_3428 ENOG4105EHG Permease protein I33_3429 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) I33_3431 ENOG4105EWI Short-chain dehydrogenase reductase Sdr I33_3432 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein I33_3434 ENOG4105DPZ Two component transcriptional regulator (Winged helix family I33_3437 ENOG4106DF4 Sigma-70, region 4 I33_3439 ENOG4105F0F Oxalate decarboxylase I33_3441 ENOG4107RBB ABC transporter, permease I33_3442 ENOG4105C19 ABC transporter I33_3443 ENOG4108WMK Efflux transporter RND family MFP subunit I33_3445 ENOG4105E0A ABC, transporter I33_3446 ENOG4105EHG Permease protein I33_3447 ENOG4105DQ5 transport system permease protein I33_3451 ENOG4105D5Q Arginine ornithine antiporter I33_3453 ENOG4107K5X Membrane-bound metal-dependent hydrolase I33_3454 ENOG4107QZ2 Sulfatase I33_3455 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family I33_3456 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein I33_3457 ENOG4105E0C molybdate abc transporter I33_3460 ENOG4105EEQ Na H antiporter I33_3461 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) I33_3462 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) I33_3463 ENOG4105EEM helicase I33_3465 ENOG4105EN6 Membrane I33_3468 ENOG4107ZQN disulfide bond I33_3469 ENOG4105C59 p-type ATPase I33_3470 ENOG4105C59 p-type ATPase I33_3471 ENOG410681U heavy metal transport detoxification protein I33_3472 ENOG4105VPX protein, conserved in bacteria I33_3473 ENOG4105D9R oxidoreductase I33_3474 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) I33_3475 ENOG4105ME7 Membrane I33_3476 ENOG4105RXJ I33_3477 ENOG4105KPY Small multidrug resistance protein I33_3478 ENOG4105KBX Transcriptional regulator, TetR family I33_3479 ENOG4105EWI Short-chain dehydrogenase reductase Sdr I33_3482 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) I33_3483 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) I33_3485 ENOG4105XZU Preprotein translocase, subunit SecG I33_3490 ENOG4105KVH Transcriptional regulator I33_3491 ENOG4105C8Q Methyl-accepting chemotaxis I33_3492 ENOG4105R40 Glycine betaine carnitine choline I33_3493 ENOG4108HQR Glycine betaine I33_3494 ENOG4105E90 ABC transporter I33_3495 ENOG4108IJ8 ABC transporter I33_3496 ENOG4107HG4 Transcriptional regulator I33_3497 ENOG4105R40 Glycine betaine carnitine choline I33_3498 ENOG4108HQR Glycine betaine I33_3499 ENOG4105E90 ABC transporter I33_3500 ENOG4108IJ8 ABC transporter I33_3501 ENOG4107HG4 Transcriptional regulator I33_3502 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein I33_3503 ENOG4108QCI YvbH-like oligomerisation region I33_3505 ENOG4105T65 Membrane-associated protein I33_3506 ENOG4108W0I acetyltransferase I33_3507 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) I33_3508 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) I33_3509 ENOG4105CP7 Triose-phosphate isomerase I33_3510 ENOG4105BZA Phosphoglycerate kinase I33_3512 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase I33_3515 ENOG4105CMD Transcriptional regulator, GntR family I33_3516 ENOG4105DEN Luciferase family I33_3517 ENOG4105GZI Transcriptional regulator I33_3518 ENOG4107RT3 EamA-like transporter family I33_3520 ENOG4105VRS hydrolase family 18 I33_3521 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) I33_3522 ENOG4107QR9 Iron-sulfur cluster binding protein I33_3523 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) I33_3525 ENOG4105BZU Histidine kinase I33_3526 ENOG4105KCT ABC transporter I33_3527 ENOG4108M15 ABC transporter I33_3529 ENOG4107R6F Alpha Beta Hydrolase Fold protein I33_3530 ENOG4108MJI response regulator I33_3533 ENOG4105EG2 ABC transporter, permease I33_3535 ENOG4107FKK extracellular solute-binding protein family 1 I33_3537 ENOG4105JXH GntR family transcriptional regulator I33_3538 ENOG4105DAA L-lactate I33_3539 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) I33_3542 ENOG4108ZPC Polysaccharide pyruvyl transferase I33_3543 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase I33_3544 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family I33_3545 ENOG4105D3Q Sugar transferase I33_3547 ENOG4105K64 Glycosyl transferase, family 2 I33_3549 ENOG4107QRS glycosyltransferase group 2 family protein I33_3550 ENOG41068W6 Capsular polysaccharide biosynthesis protein I33_3551 ENOG4108KMV Glycosyl transferase (Group 1 I33_3552 ENOG4105K64 Glycosyl transferase, family 2 I33_3553 ENOG4108PQP glycosyl transferase group 1 I33_3555 ENOG4108QV3 biosynthesis protein I33_3556 ENOG4105HTX biosynthesis protein I33_3558 ENOG4105EBR Carboxylesterase I33_3560 ENOG4105PY6 Phenolic acid decarboxylase I33_3561 ENOG4105NI3 Protein of unknown function (DUF3237) I33_3563 ENOG4105FQP Beta-lactamase I33_3564 ENOG4105EDQ levansucrase EC 2.4.1.10 I33_3565 ENOG4108HKT sucrose-6-phosphate hydrolase I33_3566 ENOG4107QTZ amino acid I33_3573 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) I33_3574 ENOG4107URF beta-phospho-glucomutase I33_3575 ENOG4105CG3 alpha amylase, catalytic region I33_3578 ENOG4105EG2 ABC transporter, permease I33_3579 ENOG4105D56 permease protein I33_3580 ENOG4107FKK extracellular solute-binding protein family 1 I33_3581 ENOG4108IUK alpha amylase, catalytic I33_3582 ENOG4105FKQ transcriptional regulator I33_3583 ENOG4108URH decarboxylase I33_3584 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain I33_3585 ENOG4105CHH sulfate transporter I33_3586 ENOG4108V2W Carbonate dehydratase I33_3587 ENOG4105C5I Dehydrogenase I33_3589 ENOG4105C19 ABC transporter I33_3590 ENOG4105EWM Histidine kinase I33_3592 ENOG4107A6P I33_3593 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase I33_3594 ENOG4105KRI phosphocarrier protein (HPr I33_3595 ENOG4105CIE May be required for sporulation (By similarity) I33_3596 ENOG4105CHW UPF0052 protein I33_3597 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) I33_3598 ENOG4108Z4K mutator MutT protein I33_3599 ENOG4105C3M thioredoxin reductase I33_3609 ENOG4105BZ1 (ABC) transporter I33_3611 ENOG4106FGC I33_3617 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase I33_3618 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) I33_3619 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase I33_3620 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) I33_3621 ENOG4105ECC imidazole-glycerol-phosphate dehydratase I33_3622 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) I33_3623 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) I33_3624 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) I33_3626 ENOG4108E16 pectate lyase I33_3627 ENOG4108S4C acetyltransferase I33_3628 ENOG4107XGZ Hydrolase I33_3629 ENOG4105HKU nucleoside recognition domain-containing protein I33_3630 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) I33_3631 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) I33_3632 ENOG4105CE4 GlcNAc 6-P deacetylase I33_3633 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) I33_3634 ENOG4105FDP GntR family transcriptional regulator I33_3635 ENOG41088CQ domain protein I33_3637 ENOG41086DT Membrane protein of unknown function I33_3638 ENOG41067S9 phage shock protein C, PspC I33_3639 ENOG4108PY7 I33_3643 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) I33_3644 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) I33_3648 ENOG4105MKU Transcriptional regulator I33_3652 ENOG4105CN1 protease I33_3653 ENOG4105CRP Part of the ABC transporter FtsEX involved in I33_3654 ENOG4105CAK Cell division ATP-binding protein ftsE I33_3657 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) I33_3659 ENOG4105MS2 ribosomal subunit Interface protein I33_3662 ENOG4105MQ3 flagellar protein FliS I33_3663 ENOG4107RT6 flagellar hook-associated I33_3664 ENOG41083S7 flagellar protein FlaG I33_3665 ENOG4105I03 Flagellin I33_3666 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) I33_3667 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) I33_3668 ENOG4105MKD I33_3669 ENOG4105DTJ flagellar hook-associated protein I33_3670 ENOG4105E1Q flagellar hook-associated protein I33_3673 ENOG4105RU3 I33_3674 ENOG41081UC Inherit from COG: Competence protein I33_3678 ENOG4105WH1 Two component transcriptional regulator luxr family I33_3679 ENOG4105BZU Histidine kinase I33_3680 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein I33_3681 ENOG4108KGH TRANSCRIPTIONal I33_3682 ENOG4105ESV Glycosyl transferase, family 4 I33_3683 ENOG4107EF8 Glycosyl transferase (Group 1 I33_3686 ENOG4105QZI O-Antigen Polymerase I33_3687 ENOG4105C6Y Udp-glucose 6-dehydrogenase I33_3688 ENOG4107RA4 Glycosyl transferase (Group 1 I33_3689 ENOG4105PSV Polysaccharide Biosynthesis Protein I33_3690 ENOG4105D3Q Sugar transferase I33_3692 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase I33_3693 ENOG4105JFG SpoIID LytB domain protein I33_3696 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase I33_3697 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase I33_3698 ENOG4105EY8 ABC transporter I33_3701 ENOG4107SJB teichoic acid biosynthesis I33_3702 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) I33_3703 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase I33_3705 ENOG4107RZX Teichoic acid biosynthesis protein I33_3706 ENOG410651K Teichoic acid biosynthesis protein C I33_3708 ENOG4105DG6 mannose-6-phosphate isomerase I33_3711 ENOG4108NHD germination protein I33_3712 ENOG4105C54 Major Facilitator superfamily I33_3713 ENOG4108KGH TRANSCRIPTIONal I33_3714 ENOG4105J7I hydrolase I33_3715 ENOG4105K4H Nlp p60 protein I33_3717 ENOG4105PNM synthesis protein I33_3719 ENOG4105N98 Capsule biosynthesis protein capB I33_3720 ENOG4105ETE Transcriptional regulator (LacI family I33_3721 ENOG4108RVA ribokinase I33_3722 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) I33_3723 ENOG4105C2J ABC transporter I33_3724 ENOG4105CNN ABC, transporter I33_3725 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator I33_3728 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein I33_3729 ENOG4107FQX Alpha-acetolactate decarboxylase I33_3731 ENOG4107RSM transcriptional regulator I33_3734 ENOG4106UIA I33_3737 ENOG4107XC4 flavin reductase domain protein, FMN-binding I33_3739 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) I33_3741 ENOG4105CAH Chromate I33_3742 ENOG4105FGV Chromate I33_3743 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) I33_3753 ENOG4108XI2 Domain of unknown function (DUF1963) I33_3754 ENOG4105C6Y Udp-glucose 6-dehydrogenase I33_3755 ENOG4108RB3 Capsular polysaccharide biosynthesis protein I33_3756 ENOG4107YJ4 chain length determinant protein I33_3757 ENOG4105HTX biosynthesis protein I33_3759 ENOG4105KBK Zinc finger, swim domain protein I33_3760 ENOG4105C0D helicase I33_3761 ENOG410667J hydrolase I33_3762 ENOG4105E98 transcriptional regulator DeoR family I33_3763 ENOG4105Z8H single-stranded DNA-binding protein I33_3769 ENOG4108VAC response regulator I33_3771 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) I33_3772 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) I33_3774 ENOG4105CGA flagellar basal-body rod protein FlgG I33_3776 ENOG4105DFF Rod shape-determining protein mreb I33_3777 ENOG4105MT0 Sporulation transcriptional regulator spoiiid I33_3778 ENOG4107MII Sugar-specific transcriptional regulator TrmB I33_3779 ENOG4105CZM Major Facilitator I33_3781 ENOG4108M26 parallel beta-helix repeat protein I33_3782 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease I33_3783 ENOG41080V3 Major Facilitator superfamily I33_3784 ENOG4105D3W isochorismatase I33_3785 ENOG4107P26 I33_3786 ENOG4105BZU Histidine kinase I33_3788 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase I33_3790 ENOG4105FRN stage II sporulation protein I33_3791 ENOG4107TCE N-acetyltransferase I33_3795 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) I33_3796 ENOG4107TXC Transcriptional regulator I33_3797 ENOG4106BRK I33_3798 ENOG4108RYK Nad-dependent epimerase dehydratase I33_3799 ENOG4108Z40 Transcriptional regulator I33_3800 ENOG4105CQM Urea amidohydrolase subunit alpha I33_3801 ENOG4105KI2 Urea amidohydrolase subunit beta I33_3802 ENOG4108YZ9 Urea amidohydrolase subunit gamma I33_3811 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) I33_3813 ENOG4108TF4 von Willebrand factor, type A I33_3818 ENOG4105JFG SpoIID LytB domain protein I33_3819 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) I33_3821 ENOG4106778 Protein of unknown function (DUF1146) I33_3823 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) I33_3824 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) I33_3825 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) I33_3826 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) I33_3830 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) I33_3832 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) I33_3833 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) I33_3834 ENOG4108UIC UPF0340 protein I33_3835 ENOG4108YZG isomerase I33_3837 ENOG4107WAU Protein tyrosine phosphatase I33_3838 ENOG410815N Probably functions as a manganese efflux pump (By similarity) I33_3839 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) I33_3844 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) I33_3845 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) I33_3846 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase I33_3848 ENOG4107TT2 Auxin Efflux Carrier I33_3849 ENOG4105C6K Malic enzyme I33_3850 ENOG4107104 thymidine kinase I33_3851 ENOG41082DI 50s ribosomal protein l31 I33_3852 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) I33_3854 ENOG4105CBT Fructose-1,6-bisphosphatase I33_3855 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) I33_3856 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway I33_3857 ENOG4105D2N Aldolase I33_3858 ENOG410812K response regulator receiver protein I33_3860 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) I33_3862 ENOG4105C1G acyl-Coa dehydrogenase I33_3863 ENOG4105DF6 Fe-S oxidoreductase I33_3865 ENOG4105E5J UV damage endonuclease I33_3867 ENOG4105NAE bifunctional deaminase-reductase domain protein I33_3868 ENOG4105BZ1 (ABC) transporter I33_3869 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) I33_3872 ENOG4105R3A Nitrate reductase I33_3873 ENOG4108IUE nitrate reductase beta subunit I33_3877 ENOG4107V6Q Cyclic nucleotide-binding domain I33_3879 ENOG4105C75 arginyL-tRNA synthetase I33_3880 ENOG410684U Domain of unknown function (DUF1934) I33_3882 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E I33_3892 ENOG4107JM4 Tetratricopeptide repeat I33_3893 ENOG4108UIN ybak prolyl-trna synthetase associated region I33_3894 ENOG4105CYW agmatinase I33_3895 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) I33_3896 ENOG4105BZ4 penicillin-binding protein I33_3898 ENOG4108XFG YwhD family I33_3899 ENOG4108Z4T Peptidase M50 I33_3900 ENOG41069HH 4-oxalocrotonate tautomerase I33_3901 ENOG41067TZ transcriptional regulator, MarR family I33_3902 ENOG4105C22 threonyL-tRNA synthetase I33_3904 ENOG4105C57 major facilitator superfamily I33_3905 ENOG41062ES Transcriptional regulator I33_3907 ENOG4105DCI Phosphohydrolase I33_3909 ENOG4108VCI transcription factor, rsfa family I33_3910 ENOG4108RNG Permease of the drug metabolite transporter I33_3912 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) I33_3913 ENOG4105DUM transcriptional regulator, lysR family I33_3914 ENOG4108IJ2 phosphate acetyltransferase I33_3917 ENOG4105CHM Aminotransferase I33_3919 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase I33_3920 ENOG4105CHR reductase I33_3921 ENOG4106CHD Bacilysin biosynthesis protein bacB I33_3922 ENOG41061WN bacilysin biosynthesis protein I33_3924 ENOG4105FCW Major Facilitator superfamily I33_3927 ENOG4105C26 Dehydrogenase I33_3929 ENOG4105D82 Glutamate dehydrogenase I33_3934 ENOG4105C1B dTDP-glucose 4-6-dehydratase I33_3935 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) I33_3937 ENOG4107TY6 Acylneuraminate cytidylyltransferase I33_3939 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD I33_3940 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase I33_3949 ENOG4105C26 Dehydrogenase I33_3950 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) I33_3951 ENOG4108RJ9 Glycosyl transferase, family 2 I33_3952 ENOG4105DWF phosphomethylpyrimidine kinase I33_3955 ENOG4105C5Y PTS System I33_3956 ENOG4108QTI )-transporter I33_3960 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin I33_3961 ENOG4105DEN Luciferase family I33_3962 ENOG4108DBC nitroreductase I33_3965 ENOG41060D1 Quinol oxidase I33_3966 ENOG4105CCU oxidase (Subunit III) I33_3967 ENOG4105BZ9 Cytochrome C oxidase, subunit I I33_3968 ENOG4105E2S oxidase) subunit II I33_3969 ENOG4107BMA Transglycosylase associated protein I33_3971 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) I33_3972 ENOG4105WH5 Teichoic acid glycosylation protein I33_3977 ENOG4107ZXU DSBA oxidoreductase I33_3978 ENOG4105DBE peroxidase I33_3979 ENOG410650H (LipO)protein I33_3980 ENOG4107SJW iron permease, FTR1 I33_3981 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) I33_3983 ENOG4105CMU LysR family (Transcriptional regulator I33_3984 ENOG4105VAW lrga family I33_3985 ENOG41067MG lrgb family I33_3986 ENOG4105D8G Major Facilitator superfamily I33_3988 ENOG4105DR4 Methyltransferase I33_3992 ENOG4105CK1 PTS System I33_3994 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin I33_3997 ENOG4105X1N Glycosyl transferase family 8 I33_3999 ENOG4105GVJ transcriptional regulator I33_4000 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) I33_4001 ENOG4105IIU Aminopeptidase I33_4003 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase I33_4006 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) I33_4007 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein I33_4009 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD I33_4010 ENOG4108VHC Short-chain dehydrogenase reductase Sdr I33_4011 ENOG4105CM2 brancheD-chain amino acid aminotransferase I33_4012 ENOG4105F8D glycoside hydrolase family 4 I33_4013 ENOG4105VCP PTS System I33_4014 ENOG4105CK1 PTS System I33_4015 ENOG4105VZJ PTS System I33_4016 ENOG4105EMD TRANSCRIPTIONal I33_4018 ENOG4108VX5 3-methyladenine DNA glycosylase I33_4019 ENOG4105CH6 catalase I33_4022 ENOG4105DA5 (ABC) transporter I33_4023 ENOG41069JR I33_4027 ENOG4105ETS cytosine purines uracil thiamine allantoin I33_4028 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) I33_4030 ENOG4108JJ8 (ABC) transporter I33_4031 ENOG4108JJ9 ABC, transporter I33_4032 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii I33_4033 ENOG4105C4M (Ubiquinol oxidase) subunit I I33_4034 ENOG4105D2K citrate carrier protein I33_4037 ENOG4107BJW polysaccharide deacetylase I33_4042 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) I33_4044 ENOG4105CMR udp-glucose 4-epimerase I33_4045 ENOG4105KIS phospholipid-binding protein I33_4046 ENOG4108WAV Transcriptional regulator I33_4049 ENOG4105BZU Histidine kinase I33_4050 ENOG4105WH1 Two component transcriptional regulator luxr family I33_4051 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) I33_4057 ENOG4105DTD Dehydrogenase I33_4058 ENOG4108IIH CoA-transferase subunit B I33_4059 ENOG4105D6N CoA-transferase, subunit a I33_4060 ENOG4105CY2 Citrate transporter I33_4061 ENOG4105DHI Methyltransferase I33_4066 ENOG4105CH6 catalase I33_4068 ENOG4105D4T Citrate transporter I33_4069 ENOG4108RZ2 Glycoside hydrolase family 16 I33_4070 ENOG4105CID antiterminator I33_4073 ENOG4105DEU major facilitator superfamily I33_4074 ENOG4105C1J atp-dependent rna helicase I33_4075 ENOG4107TDE lipolytic protein G-D-S-L family I33_4083 ENOG4107YZX Universal stress protein I33_4084 ENOG4105CS2 ec 3.2.1.21 I33_4085 ENOG4105C5Y PTS System I33_4093 ENOG4107EV6 Inherit from COG: YD repeat protein I33_4099 ENOG4105M6F mutator MutT protein I33_4100 ENOG4106Z5D Glycoside Hydrolase Family 43 I33_4103 ENOG4105C84 Histidine ammonia-lyase I33_4104 ENOG4105CGP Urocanate hydratase I33_4105 ENOG4105CI2 imidazolone-5-propionate hydrolase I33_4106 ENOG4107W25 arginase agmatinase formiminoglutamase I33_4108 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) I33_4109 ENOG4105D9N nucleoside I33_4111 ENOG4107RHR regulatoR I33_4112 ENOG4108TM9 integral membrane protein I33_4113 ENOG4105ENY Ethanolamine utilization protein eutH I33_4114 ENOG4108PGP mmge prpd family protein I33_4115 ENOG4105CH2 amidohydrolase I33_4117 ENOG4108HW4 amino acid AbC transporter I33_4118 ENOG4105EAB amino acid AbC transporter I33_4119 ENOG4108XSB acetyltransferase, (GNAT) family I33_4120 ENOG4105CPU Monooxygenase I33_4122 ENOG4107QHE Choloylglycine hydrolase I33_4123 ENOG410667J hydrolase I33_4130 ENOG4108V5C ABC transporter I33_4136 ENOG4105D2N Aldolase I33_4137 ENOG4107TRN Xylose isomerase domain protein TIM barrel I33_4138 ENOG4105F0H myo-inositol catabolism protein I33_4139 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) I33_4141 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) I33_4142 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) I33_4143 ENOG4105D7K pfkb domain protein I33_4145 ENOG4105C26 Dehydrogenase I33_4147 ENOG4105CPC Aldo Keto reductase I33_4152 ENOG4107QNK )-transporter I33_4153 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) I33_4155 ENOG41061TZ Short-chain dehydrogenase reductase Sdr I33_4156 ENOG4105ST3 Transcriptional regulator I33_4157 ENOG4105C26 Dehydrogenase I33_4160 ENOG41085PJ rdd domain containing protein I33_4163 ENOG4105J7D transcriptional regulator I33_4164 ENOG4107JEE Short-chain dehydrogenase reductase Sdr I33_4165 ENOG41061AU MarR family Transcriptional regulator I33_4167 ENOG41067MG lrgb family I33_4169 ENOG4105BZW Glycerate kinase I33_4170 ENOG4105G3Z GntR family transcriptional regulator I33_4171 ENOG4105CMG Carbohydrate kinase I33_4172 ENOG4105C6Z Gluconate I33_4173 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) I33_4174 ENOG4105D3R alkyl hydroperoxide reductase I33_4175 ENOG4108JU3 Alkyl hydroperoxide reductase I33_4176 ENOG4105CS2 ec 3.2.1.21 I33_4177 ENOG4105C5Y PTS System I33_4178 ENOG4108S3Y transcriptional regulator I33_4180 ENOG4106KKU I33_4181 ENOG4108Z15 abc transporter atp-binding protein I33_4183 ENOG4105Y2Z radical SAM domain protein I33_4185 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 I33_4187 ENOG4105DQ6 Transposase I33_4191 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) I33_4194 ENOG4105E2A Dehydrogenase I33_4198 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) I33_4199 ENOG4105WQG acetyltransferase I33_4200 ENOG410780I phosphoprotein phosphatase activity I33_4202 ENOG41066UZ arginase EC 3.5.3.1 I33_4203 ENOG4108IQI permease I33_4204 ENOG4105C8Y Acetylornithine aminotransferase I33_4205 ENOG4108JUB Transcriptional regulator I33_4206 ENOG4105C0H protease I33_4207 ENOG4105Q2H domain protein I33_4210 ENOG4105BZU Histidine kinase I33_4211 ENOG4105CK6 Two component transcriptional regulator (Winged helix family I33_4216 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis I33_4217 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase I33_4218 ENOG4105CDU Replicative dna helicase I33_4222 ENOG4105DJ2 Major Facilitator Superfamily I33_4223 ENOG4105EDW glycosyl transferase, family 39 I33_4224 ENOG4105K9Q Binds to the 23S rRNA (By similarity) I33_4225 ENOG4105BZR domain protein I33_4226 ENOG4108XMW Membrane I33_4230 ENOG4105KVH Transcriptional regulator I33_4231 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase I33_4235 ENOG41090E6 transcriptional regulator MERR family I33_4237 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein I33_4238 ENOG4105DDN Pentapeptide repeat-containing protein I33_4239 ENOG4105D94 Major Facilitator Superfamily I33_4240 ENOG4107RSM transcriptional regulator I33_4241 ENOG41082BV acetyltransferase I33_4242 ENOG41081I9 integral membrane protein I33_4243 ENOG4107V2S Transcriptional regulator I33_4244 ENOG4108VP3 Lysine exporter protein (LysE YggA) I33_4246 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase I33_4248 ENOG4108U05 Transcriptional regulator I33_4249 ENOG41082BV acetyltransferase I33_4252 ENOG4105C7Z Conserved Protein I33_4253 ENOG4107FCW Abortive infection protein I33_4255 ENOG4108UW5 maltose o-acetyltransferase I33_4256 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase I33_4258 ENOG4105CGK Exodeoxyribonuclease III I33_4259 ENOG4108UUM single-stranded DNA-binding protein I33_4260 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) I33_4261 ENOG4105C3G gtp-binding protein I33_4262 ENOG4108J2R molybdopterin oxidoreductase I33_4263 ENOG4105VDK protein, conserved in bacteria I33_4265 ENOG4108ZDA Sporulation protein YyaC I33_4266 ENOG4105FA0 parb-like partition protein I33_4267 ENOG4107QJE Chromosome Partitioning Protein I33_4270 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) I33_4271 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) I33_4272 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) I33_4275 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)