locus-tag	class	description
I33_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I33_0002	COG0592	DNA-directed DNA polymerase activity
I33_0003	COG2501	S4 domain
I33_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I33_0006	COG0187	DNA topoisomerase II activity
I33_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I33_0014	COG0516	GMP reductase activity
I33_0014	COG0517	IMP dehydrogenase activity
I33_0015	COG1686	Belongs to the peptidase S11 family
I33_0016	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I33_0017	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I33_0018	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I33_0020	COG1428	Deoxynucleoside kinase
I33_0021	COG1428	Deoxynucleoside kinase
I33_0023	COG1335	isochorismatase
I33_0024	COG0590	tRNA wobble adenosine to inosine editing
I33_0025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I33_0026	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I33_0027	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I33_0036	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I33_0037	COG3853	Toxic anion resistance protein (TelA)
I33_0038	COG1982	Orn Lys Arg decarboxylase major
I33_0039	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I33_0040	COG3870	Protein conserved in bacteria
I33_0041	COG1728	Protein conserved in bacteria
I33_0042	COG0470	DNA polymerase III
I33_0043	COG1774	PSP1 C-terminal conserved region
I33_0044	COG4467	Involved in initiation control of chromosome replication
I33_0045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I33_0046	COG2827	Endonuclease containing a URI domain
I33_0047	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I33_0048	COG2002	toxin-antitoxin pair type II binding
I33_0049	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_0049	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_0050	COG0084	hydrolase, TatD family'
I33_0051	COG3584	3D domain protein
I33_0051	COG3583	domain protein
I33_0052	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I33_0053	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I33_0055	COG4466	Protein conserved in bacteria
I33_0057	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I33_0058	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I33_0059	COG0251	oxidation-reduction process
I33_0060	COG2088	sporulation resulting in formation of a cellular spore
I33_0062	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I33_0063	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I33_0064	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I33_0065	COG0193	aminoacyl-tRNA hydrolase activity
I33_0067	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I33_0068	COG2002	toxin-antitoxin pair type II binding
I33_0069	COG2244	polysaccharide biosynthetic process
I33_0070	COG3956	TIGRFAM MazG family protein
I33_0071	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I33_0075	COG1098	S1 RNA binding domain
I33_0079	COG2304	oxidoreductase activity
I33_0080	COG0515	serine threonine protein kinase
I33_0081	COG0037	tRNA processing
I33_0083	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I33_0084	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I33_0085	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I33_0086	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I33_0087	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I33_0088	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I33_0089	COG0512	Glutamine amidotransferase of anthranilate synthase
I33_0090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I33_0091	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I33_0092	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I33_0093	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I33_0094	COG1396	sequence-specific DNA binding
I33_0095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I33_0096	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I33_0113	COG4463	regulation of RNA biosynthetic process
I33_0114	COG3880	PFAM UvrB UvrC protein
I33_0115	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I33_0116	COG0542	response to heat
I33_0117	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I33_0118	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I33_0119	COG4956	integral membrane protein (PIN domain superfamily)
I33_0120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I33_0121	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I33_0122	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I33_0124	COG1045	serine acetyltransferase
I33_0125	COG0215	cysteine-tRNA ligase activity
I33_0126	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I33_0127	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I33_0128	COG3688	RNA-binding protein containing a PIN domain
I33_0129	COG1595	DNA-templated transcription, initiation
I33_0130	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I33_0131	COG0250	Participates in transcription elongation, termination and antitermination
I33_0132	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I33_0133	COG0081	regulation of translation
I33_0134	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I33_0135	COG0222	ribosome binding
I33_0136	COG2813	Specifically methylates the guanine in position
I33_0137	COG0085	RNA polymerase activity
I33_0138	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I33_0140	COG1358	cellular component organization or biogenesis
I33_0141	COG0049	tRNA binding
I33_0142	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I33_0143	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I33_0144	COG0596	Alpha beta hydrolase
I33_0145	COG0051	transcription antitermination factor activity, RNA binding
I33_0146	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I33_0147	COG0088	Forms part of the polypeptide exit tunnel
I33_0148	COG0089	rRNA binding
I33_0149	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I33_0150	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I33_0151	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I33_0152	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I33_0153	COG0255	Belongs to the universal ribosomal protein uL29 family
I33_0154	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I33_0156	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I33_0158	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I33_0159	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I33_0160	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I33_0162	COG1841	ribosomal large subunit assembly
I33_0163	COG0200	Binds to the 23S rRNA
I33_0164	COG0201	protein transport
I33_0165	COG0563	adenylate kinase activity
I33_0166	COG0024	Methionine aminopeptidase
I33_0167	COG2163	COG2163 Ribosomal protein L14E L6E L27E
I33_0168	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I33_0169	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I33_0170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I33_0171	COG0202	RNA polymerase activity
I33_0172	COG0203	ribosomal protein L17
I33_0173	COG1122	ATPase activity
I33_0174	COG1122	ATPase activity
I33_0175	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I33_0176	COG0101	tRNA pseudouridine synthase activity
I33_0177	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I33_0178	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I33_0179	COG2226	methyltransferase
I33_0181	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_0182	COG0489	protein tyrosine kinase activity
I33_0184	COG2194	sulfuric ester hydrolase activity
I33_0185	COG0726	polysaccharide deacetylase
I33_0203	COG0659	secondary active sulfate transmembrane transporter activity
I33_0204	COG0385	Bile acid
I33_0205	COG2819	hydrolase of the alpha beta superfamily
I33_0206	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_0207	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_0208	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_0209	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_0209	COG2207	Transcriptional regulator
I33_0210	COG3876	Protein conserved in bacteria
I33_0211	COG1472	Belongs to the glycosyl hydrolase 3 family
I33_0212	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I33_0213	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_0213	COG1263	PTS System
I33_0214	COG1737	Transcriptional regulator
I33_0215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I33_0216	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_0217	COG1683	Conserved Protein
I33_0223	COG1595	DNA-templated transcription, initiation
I33_0224	COG5662	AntiSigma factor
I33_0225	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I33_0226	COG4856	YbbR-like protein
I33_0227	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I33_0229	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I33_0230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I33_0231	COG3002	Belongs to the UPF0753 family
I33_0232	COG0288	reversible hydration of carbon dioxide
I33_0234	COG5609	conserved protein (DUF2294)
I33_0235	COG0640	Transcriptional regulator
I33_0237	COG2814	Major facilitator Superfamily
I33_0240	COG0515	serine threonine protein kinase
I33_0243	COG1113	amino acid transport
I33_0246	COG2602	Beta-lactamase
I33_0247	COG2124	cytochrome p450
I33_0249	COG0531	amino acid
I33_0251	COG0584	glycerophosphoryl diester phosphodiesterase
I33_0252	COG2271	Major facilitator Superfamily
I33_0254	COG1846	Transcriptional regulator
I33_0254	COG0456	acetyltransferase
I33_0255	COG2271	Major facilitator Superfamily
I33_0259	COG3409	Peptidoglycan-binding domain 1 protein
I33_0260	COG0697	spore germination
I33_0261	COG1917	Cupin 2, conserved barrel domain protein
I33_0261	COG2207	Transcriptional regulator
I33_0262	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I33_0263	COG3591	Belongs to the peptidase S1B family
I33_0265	COG0596	Alpha beta hydrolase
I33_0266	COG1183	phosphatidylcholine synthase activity
I33_0267	COG0586	Pfam SNARE associated Golgi protein
I33_0268	COG0688	phosphatidylethanolamine metabolic process
I33_0270	COG2312	Erythromycin esterase
I33_0272	COG1301	dicarboxylic acid transport
I33_0273	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_0273	COG1263	PTS System
I33_0273	COG2190	(PTS) system
I33_0274	COG0363	glucosamine-6-phosphate deaminase activity
I33_0278	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I33_0279	COG0833	amino acid
I33_0280	COG2040	homocysteine
I33_0282	COG1115	amino acid carrier protein
I33_0283	COG2066	Belongs to the glutaminase family
I33_0285	COG0784	Response regulator, receiver
I33_0286	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I33_0287	COG1012	belongs to the aldehyde dehydrogenase family
I33_0288	COG2271	Major facilitator Superfamily
I33_0289	COG4948	Mandelate Racemase Muconate Lactonizing
I33_0290	COG2186	Transcriptional regulator
I33_0291	COG2721	sulfolactate sulfo-lyase activity
I33_0293	COG3173	Aminoglycoside phosphotransferase
I33_0295	COG0697	spore germination
I33_0300	COG3773	Cell wall hydrolase
I33_0301	COG2304	oxidoreductase activity
I33_0303	COG3540	Alkaline phosphatase
I33_0304	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I33_0305	COG0805	protein transport
I33_0306	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I33_0307	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I33_0308	COG0477	Major facilitator Superfamily
I33_0309	COG1309	transcriptional regulator
I33_0310	COG0252	asparaginase activity
I33_0311	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I33_0312	COG1714	RDD family
I33_0313	COG3012	SEC-C Motif Domain Protein
I33_0313	COG1405	negative regulation of cell septum assembly
I33_0314	COG3290	protein histidine kinase activity
I33_0315	COG3279	Response regulator of the LytR AlgR family
I33_0316	COG4555	ABC transporter
I33_0317	COG1668	transmembrane transport
I33_0318	COG0667	Aldo Keto reductase
I33_0320	COG1595	DNA-templated transcription, initiation
I33_0321	COG1595	DNA-templated transcription, initiation
I33_0322	COG1876	peptidase activity
I33_0323	COG0457	Tetratricopeptide repeat
I33_0324	COG1028	Short-chain dehydrogenase reductase Sdr
I33_0325	COG0366	Alpha amylase catalytic
I33_0326	COG0803	Belongs to the bacterial solute-binding protein 9 family
I33_0327	COG1121	(ABC) transporter
I33_0328	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I33_0329	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_0330	COG2310	stress, protein
I33_0331	COG2310	stress, protein
I33_0332	COG2310	stress, protein
I33_0333	COG0861	Integral membrane protein TerC family
I33_0335	COG3853	Toxic anion resistance protein (TelA)
I33_0336	COG0477	Major facilitator Superfamily
I33_0337	COG2814	Major facilitator Superfamily
I33_0338	COG0640	Transcriptional regulator
I33_0339	COG0517	IMP dehydrogenase activity
I33_0339	COG4175	Glycine betaine
I33_0340	COG4176	ABC-type proline glycine betaine transport system permease component
I33_0341	COG2113	Glycine betaine
I33_0342	COG1473	amidohydrolase
I33_0343	COG1288	antiporter activity
I33_0348	COG0366	Alpha amylase catalytic
I33_0349	COG0039	L-malate dehydrogenase activity
I33_0350	COG1620	l-lactate permease
I33_0351	COG2814	Major facilitator Superfamily
I33_0352	COG1846	Transcriptional regulator
I33_0353	COG1280	lysine exporter protein (LysE YggA)
I33_0354	COG3403	YqcI/YcgG family
I33_0355	COG1113	amino acid transport
I33_0356	COG3665	Urea carboxylase-associated protein
I33_0357	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I33_0358	COG1660	Displays ATPase and GTPase activities
I33_0360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I33_0361	COG2226	methyltransferase
I33_0362	COG0583	DNA-binding transcription factor activity
I33_0363	COG3458	cephalosporin-C deacetylase activity
I33_0364	COG3541	Predicted nucleotidyltransferase
I33_0365	COG0506	proline dehydrogenase activity
I33_0366	COG1012	belongs to the aldehyde dehydrogenase family
I33_0367	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_0368	COG2508	Transcriptional regulator
I33_0369	COG3689	TIGRFAM TIGR03943 family protein
I33_0370	COG0701	Predicted permease
I33_0371	COG2267	carboxylic ester hydrolase activity
I33_0372	COG0492	ferredoxin-NADP+ reductase activity
I33_0373	COG1587	Uroporphyrinogen-III synthase
I33_0373	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I33_0374	COG2146	nitrite reductase [NAD(P)H] activity
I33_0375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I33_0376	COG0243	molybdopterin cofactor binding
I33_0377	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I33_0378	COG2223	nitrite transmembrane transporter activity
I33_0379	COG1469	GTP cyclohydrolase I activity
I33_0380	COG1376	ErfK ybiS ycfS ynhG family protein
I33_0383	COG0523	cobalamin synthesis protein
I33_0384	COG0765	amino acid transport
I33_0385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_0387	COG1714	RDD family
I33_0389	COG1846	Transcriptional regulator
I33_0392	COG2723	6-phospho-beta-galactosidase activity
I33_0394	COG3209	COG3209 Rhs family protein
I33_0395	COG3290	protein histidine kinase activity
I33_0395	COG0840	transmembrane signaling receptor activity
I33_0396	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I33_0397	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I33_0398	COG1733	regulation of RNA biosynthetic process
I33_0402	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_0403	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_0404	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I33_0405	COG2814	Major facilitator Superfamily
I33_0407	COG0697	spore germination
I33_0408	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_0410	COG2364	Membrane
I33_0411	COG1126	abc transporter atp-binding protein
I33_0412	COG0765	amino acid transport
I33_0413	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_0414	COG0583	DNA-binding transcription factor activity
I33_0415	COG0163	prenyltransferase activity
I33_0416	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I33_0419	COG0596	Alpha beta hydrolase
I33_0420	COG3104	oligopeptide transport
I33_0421	COG5434	Belongs to the glycosyl hydrolase 28 family
I33_0423	COG0697	spore germination
I33_0425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I33_0426	COG1136	(ABC) transporter
I33_0427	COG0577	efflux transmembrane transporter activity
I33_0428	COG0745	RESPONSE REGULATOR receiver
I33_0429	COG5002	protein histidine kinase activity
I33_0429	COG3850	Histidine kinase
I33_0430	COG0457	Tetratricopeptide repeat
I33_0434	COG0527	aspartate kinase activity
I33_0436	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_0437	COG4605	iron ion homeostasis
I33_0438	COG4604	ABC transporter, ATP-binding protein
I33_0439	COG4607	ABC-type enterochelin transport system periplasmic component
I33_0441	COG2814	Major facilitator Superfamily
I33_0442	COG1309	transcriptional regulator
I33_0443	COG0778	Nitroreductase
I33_0444	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I33_0445	COG0640	Transcriptional regulator
I33_0446	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_0447	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I33_0448	COG1012	belongs to the aldehyde dehydrogenase family
I33_0449	COG4975	Glucose uptake
I33_0450	COG1028	Short-chain dehydrogenase reductase Sdr
I33_0451	COG4549	nuclear export factor GLE1
I33_0452	COG1276	copper resistance
I33_0452	COG2372	response to copper ion
I33_0453	COG1349	DNA-binding transcription factor activity
I33_0455	COG2801	Transposase and inactivated derivatives
I33_0458	COG2213	PTS system mannitol-specific
I33_0459	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_0460	COG0246	Mannitol dehydrogenase
I33_0461	COG0473	3-isopropylmalate dehydrogenase activity
I33_0462	COG0681	Belongs to the peptidase S26 family
I33_0463	COG0412	Dienelactone hydrolase
I33_0464	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I33_0465	COG0561	phosphatase activity
I33_0466	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I33_0467	COG1914	H( )-stimulated, divalent metal cation uptake system
I33_0468	COG4336	lyase activity
I33_0469	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I33_0470	COG1984	allophanate hydrolase subunit 2
I33_0471	COG1414	Transcriptional regulator
I33_0472	COG2755	lipolytic protein G-D-S-L family
I33_0474	COG2329	Antibiotic biosynthesis monooxygenase
I33_0476	COG0768	penicillin binding
I33_0477	COG4989	oxidoreductase activity
I33_0478	COG3711	transcriptional antiterminator
I33_0480	COG0318	PFAM AMP-dependent synthetase and ligase
I33_0481	COG2226	methyltransferase
I33_0482	COG1028	Short-chain dehydrogenase reductase Sdr
I33_0483	COG1917	Cupin 2, conserved barrel domain protein
I33_0484	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_0485	COG3871	stress protein (general stress protein 26)
I33_0487	COG2814	Major facilitator Superfamily
I33_0488	COG1522	sequence-specific DNA binding
I33_0489	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I33_0489	COG0551	DNA topoisomerase type I activity
I33_0490	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I33_0491	COG3706	GGDEF domain
I33_0492	COG5298	Protein conserved in bacteria
I33_0493	COG1215	transferase activity, transferring glycosyl groups
I33_0495	COG0531	amino acid
I33_0498	COG0028	Belongs to the TPP enzyme family
I33_0500	COG1914	H( )-stimulated, divalent metal cation uptake system
I33_0501	COG2261	transglycosylase associated protein
I33_0502	COG4876	unkown
I33_0503	COG2217	Heavy metal translocating P-type atpase
I33_0504	COG3729	General stress protein
I33_0505	COG0662	Cupin 2, conserved barrel domain protein
I33_0506	COG2329	Antibiotic biosynthesis monooxygenase
I33_0507	COG3546	catalase activity
I33_0508	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I33_0509	COG3290	protein histidine kinase activity
I33_0510	COG4565	transcriptional regulatory protein
I33_0511	COG1301	dicarboxylic acid transport
I33_0512	COG0628	permease
I33_0514	COG1131	(ABC) transporter
I33_0515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I33_0517	COG1960	acyl-CoA dehydrogenase activity
I33_0520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I33_0521	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_0522	COG1181	Belongs to the D-alanine--D-alanine ligase family
I33_0523	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I33_0524	COG0513	Belongs to the DEAD box helicase family
I33_0525	COG3402	PFAM membrane-flanked domain
I33_0526	COG3428	Bacterial PH domain
I33_0527	COG0705	Rhomboid family
I33_0528	COG0736	holo-[acyl-carrier-protein] synthase activity
I33_0530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I33_0531	COG0864	Transcriptional regulator
I33_0532	COG2337	Toxic component of a toxin-antitoxin (TA) module
I33_0533	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_0534	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_0535	COG2172	sigma factor antagonist activity
I33_0536	COG2208	phosphoserine phosphatase activity
I33_0537	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_0538	COG2172	sigma factor antagonist activity
I33_0539	COG1191	sigma factor activity
I33_0540	COG2208	phosphoserine phosphatase activity
I33_0543	COG1673	EVE domain
I33_0544	COG1846	Transcriptional regulator
I33_0545	COG2183	response to ionizing radiation
I33_0547	COG3091	SprT-like family
I33_0555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_0556	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_0557	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_0559	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I33_0560	COG2814	Major facilitator Superfamily
I33_0563	COG5444	nuclease activity
I33_0566	COG1476	TRANSCRIPTIONal
I33_0567	COG3239	Fatty acid desaturase
I33_0568	COG1278	Cold shock
I33_0569	COG1329	Transcriptional regulator
I33_0571	COG2807	transmembrane transport
I33_0573	COG1917	Cupin 2, conserved barrel domain protein
I33_0573	COG2207	Transcriptional regulator
I33_0574	COG0697	spore germination
I33_0575	COG3708	Transcriptional regulator
I33_0575	COG2207	Transcriptional regulator
I33_0578	COG0477	Major facilitator Superfamily
I33_0580	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I33_0583	COG0745	RESPONSE REGULATOR receiver
I33_0585	COG0583	DNA-binding transcription factor activity
I33_0586	COG0114	fumarate hydratase activity
I33_0588	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I33_0589	COG1522	sequence-specific DNA binding
I33_0591	COG0697	spore germination
I33_0592	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_0593	COG2030	dehydratase
I33_0594	COG3545	Serine hydrolase
I33_0595	COG1733	regulation of RNA biosynthetic process
I33_0596	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_0597	COG0640	Transcriptional regulator
I33_0598	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I33_0599	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I33_0600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_0602	COG0726	polysaccharide deacetylase
I33_0604	COG5002	protein histidine kinase activity
I33_0605	COG0745	RESPONSE REGULATOR receiver
I33_0606	COG0697	spore germination
I33_0607	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_0609	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I33_0610	COG0640	Transcriptional regulator
I33_0611	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I33_0614	COG4585	Histidine kinase
I33_0615	COG2197	response regulator
I33_0616	COG2409	Drug exporters of the RND superfamily
I33_0617	COG1811	Na channel or pump
I33_0618	COG0789	Transcriptional regulator
I33_0618	COG4978	Transcriptional regulator
I33_0619	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I33_0620	COG0778	Nitroreductase
I33_0621	COG0346	lactoylglutathione lyase activity
I33_0622	COG2259	Doxx family
I33_0624	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_0631	COG2323	membrane
I33_0632	COG2323	membrane
I33_0633	COG0071	Belongs to the small heat shock protein (HSP20) family
I33_0636	COG1309	transcriptional regulator
I33_0639	COG0456	acetyltransferase
I33_0641	COG0673	inositol 2-dehydrogenase activity
I33_0642	COG1609	Transcriptional regulator
I33_0643	COG2814	Major facilitator Superfamily
I33_0646	COG1113	amino acid transport
I33_0648	COG2318	DinB family
I33_0649	COG1846	Transcriptional regulator
I33_0650	COG1033	growth of symbiont in host cell
I33_0650	COG2409	Drug exporters of the RND superfamily
I33_0651	COG0778	Nitroreductase
I33_0652	COG1846	Transcriptional regulator
I33_0654	COG2814	Major facilitator Superfamily
I33_0655	COG0730	response to heat
I33_0656	COG1802	Transcriptional regulator
I33_0657	COG3858	chitin binding
I33_0657	COG1388	LysM domain
I33_0658	COG1819	glycosyl
I33_0661	COG1785	Belongs to the alkaline phosphatase family
I33_0662	COG5646	InterPro IPR014922
I33_0664	COG0454	-acetyltransferase
I33_0665	COG1078	dGTPase activity
I33_0667	COG1388	LysM domain
I33_0668	COG2814	Major facilitator Superfamily
I33_0669	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_0670	COG1447	Phosphotransferase system cellobiose-specific component IIA
I33_0671	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_0672	COG2723	6-phospho-beta-galactosidase activity
I33_0673	COG2188	Transcriptional regulator
I33_0674	COG1940	carbohydrate kinase activity
I33_0675	COG1482	cell wall glycoprotein biosynthetic process
I33_0676	COG4124	Belongs to the glycosyl hydrolase 26 family
I33_0685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I33_0686	COG0802	atpase or kinase
I33_0687	COG1214	PFAM Peptidase M22, glycoprotease
I33_0688	COG0456	acetyltransferase
I33_0689	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I33_0690	COG0488	(ABC) transporter
I33_0691	COG0315	cyclic pyranopterin monophosphate synthase activity
I33_0692	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I33_0693	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I33_0694	COG0805	protein transport
I33_0696	COG1266	CAAX protease self-immunity
I33_0697	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I33_0698	COG0459	protein refolding
I33_0699	COG1073	alpha beta
I33_0700	COG0457	Tetratricopeptide repeat
I33_0702	COG1063	alcohol dehydrogenase
I33_0703	COG2211	Major facilitator Superfamily
I33_0704	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_0706	COG2814	Major facilitator Superfamily
I33_0707	COG1063	alcohol dehydrogenase
I33_0708	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I33_0709	COG0823	Involved in the tonB-independent uptake of proteins
I33_0711	COG2267	carboxylic ester hydrolase activity
I33_0714	COG1113	amino acid transport
I33_0715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I33_0716	COG0714	Associated with various cellular activities
I33_0717	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I33_0718	COG1305	Transglutaminase-like
I33_0720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I33_0720	COG0519	Catalyzes the synthesis of GMP from XMP
I33_0723	COG2252	PERMEase
I33_0725	COG3064	Membrane
I33_0727	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I33_0729	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I33_0730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I33_0731	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I33_0732	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I33_0733	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I33_0734	COG0047	phosphoribosylformylglycinamidine synthase activity
I33_0735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I33_0736	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I33_0737	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I33_0738	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I33_0739	COG0138	bifunctional purine biosynthesis protein purh
I33_0740	COG0151	Belongs to the GarS family
I33_0741	COG1522	sequence-specific DNA binding
I33_0742	COG0531	amino acid
I33_0744	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I33_0745	COG1470	cell adhesion involved in biofilm formation
I33_0746	COG4496	protein, YerC YecD
I33_0747	COG0069	glutamate synthase activity
I33_0748	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I33_0749	COG0210	DNA helicase
I33_0750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I33_0751	COG4851	CamS sex pheromone cAM373 precursor
I33_0753	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_0754	COG1285	pathogenesis
I33_0755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_0756	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I33_0757	COG0154	amidase activity
I33_0758	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I33_0759	COG1309	transcriptional regulator
I33_0760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I33_0761	COG1597	lipid kinase activity
I33_0762	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I33_0764	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I33_0766	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I33_0769	COG5444	nuclease activity
I33_0770	COG3391	amine dehydrogenase activity
I33_0774	COG0217	transcriptional regulatory protein
I33_0777	COG1309	transcriptional regulator
I33_0778	COG3631	Ketosteroid isomerase-related protein
I33_0779	COG0702	epimerase
I33_0782	COG3546	catalase activity
I33_0783	COG0454	-acetyltransferase
I33_0785	COG5578	integral membrane protein
I33_0786	COG2972	Histidine kinase
I33_0787	COG4753	response regulator
I33_0787	COG2207	Transcriptional regulator
I33_0788	COG1653	transport
I33_0789	COG1175	transmembrane transport
I33_0790	COG0395	ABC-type sugar transport system, permease component
I33_0791	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I33_0792	COG2207	Transcriptional regulator
I33_0793	COG2755	lipolytic protein G-D-S-L family
I33_0795	COG5578	integral membrane protein
I33_0796	COG3401	FG-GAP repeat protein
I33_0797	COG3401	FG-GAP repeat protein
I33_0798	COG2755	lipolytic protein G-D-S-L family
I33_0799	COG1874	Beta-galactosidase
I33_0801	COG1653	transport
I33_0802	COG4209	transmembrane transport
I33_0803	COG0395	ABC-type sugar transport system, permease component
I33_0804	COG1486	melibiose metabolic process
I33_0805	COG2323	membrane
I33_0806	COG2329	Antibiotic biosynthesis monooxygenase
I33_0807	COG0346	lactoylglutathione lyase activity
I33_0810	COG5583	Uncharacterized small protein (DUF2292)
I33_0811	COG0670	Belongs to the BI1 family
I33_0812	COG0697	spore germination
I33_0813	COG1846	Transcriptional regulator
I33_0814	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I33_0816	COG2124	cytochrome p450
I33_0816	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I33_0818	COG1368	sulfuric ester hydrolase activity
I33_0819	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I33_0820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I33_0821	COG1442	glycosyl transferase family 8
I33_0823	COG1442	glycosyl transferase family 8
I33_0824	COG2223	nitrite transmembrane transporter activity
I33_0826	COG1011	Hydrolase
I33_0827	COG0531	amino acid
I33_0828	COG1012	belongs to the aldehyde dehydrogenase family
I33_0829	COG0840	transmembrane signaling receptor activity
I33_0830	COG0488	(ABC) transporter
I33_0832	COG0789	Transcriptional regulator
I33_0833	COG2814	Major facilitator Superfamily
I33_0835	COG0488	(ABC) transporter
I33_0836	COG0513	Belongs to the DEAD box helicase family
I33_0837	COG0456	acetyltransferase
I33_0838	COG2130	NADP-dependent
I33_0840	COG1120	ATPase activity
I33_0841	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_0842	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_0843	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I33_0847	COG3866	Pectate lyase
I33_0848	COG0471	metal ion transport
I33_0853	COG0463	Glycosyl transferase, family 2
I33_0854	COG1215	transferase activity, transferring glycosyl groups
I33_0855	COG3290	protein histidine kinase activity
I33_0856	COG4565	transcriptional regulatory protein
I33_0857	COG3181	Tripartite tricarboxylate transporter family receptor
I33_0859	COG2851	Citrate transporter
I33_0860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_0861	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I33_0862	COG1254	Belongs to the acylphosphatase family
I33_0863	COG2258	MOSC domain
I33_0867	COG0024	Methionine aminopeptidase
I33_0868	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_0868	COG1263	PTS System
I33_0869	COG1368	sulfuric ester hydrolase activity
I33_0871	COG1115	amino acid carrier protein
I33_0872	COG0531	amino acid
I33_0875	COG0697	spore germination
I33_0876	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_0876	COG1263	PTS System
I33_0877	COG0366	Alpha amylase catalytic
I33_0878	COG2188	Transcriptional regulator
I33_0879	COG0778	Nitroreductase
I33_0880	COG0737	Belongs to the 5'-nucleotidase family
I33_0882	COG0693	protein deglycase activity
I33_0883	COG2814	Major facilitator Superfamily
I33_0884	COG4840	Belongs to the UPF0435 family
I33_0886	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I33_0887	COG4980	gas vesicle protein
I33_0888	COG1295	ribonuclease BN
I33_0889	COG0477	Major facilitator Superfamily
I33_0891	COG0387	Pfam Sodium calcium exchanger
I33_0893	COG0668	transmembrane transport
I33_0894	COG0535	radical SAM domain protein
I33_0896	COG0726	polysaccharide deacetylase
I33_0897	COG2084	Dehydrogenase
I33_0898	COG0598	Magnesium transport protein CorA
I33_0899	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I33_0900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I33_0901	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I33_0902	COG4637	Psort location Cytoplasmic, score
I33_0905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I33_0906	COG0022	dehydrogenase e1 component
I33_0907	COG0508	dehydrogenase complex catalyzes the overall conversion of
I33_0908	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I33_0910	COG3284	Transcriptional regulator
I33_0912	COG1742	UPF0060 membrane protein
I33_0917	COG4842	Belongs to the WXG100 family
I33_0920	COG5444	nuclease activity
I33_0923	COG1486	melibiose metabolic process
I33_0924	COG1737	Transcriptional regulator
I33_0925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_0925	COG1263	PTS System
I33_0926	COG1132	(ABC) transporter
I33_0927	COG1132	(ABC) transporter
I33_0928	COG2259	Doxx family
I33_0929	COG2514	catechol 2,3-dioxygenase activity
I33_0930	COG1917	Cupin 2, conserved barrel domain protein
I33_0930	COG4977	sequence-specific DNA binding
I33_0931	COG1082	Xylose isomerase domain protein TIM barrel
I33_0932	COG0673	inositol 2-dehydrogenase activity
I33_0933	COG4585	Histidine kinase
I33_0934	COG2197	response regulator
I33_0936	COG1131	(ABC) transporter
I33_0937	COG0842	Transport permease protein
I33_0937	COG1511	domain protein
I33_0938	COG0842	Transport permease protein
I33_0940	COG1695	Transcriptional regulator
I33_0942	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I33_0943	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I33_0944	COG2318	DinB family
I33_0945	COG2814	Major facilitator Superfamily
I33_0946	COG1846	Transcriptional regulator
I33_0947	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I33_0947	COG0392	lysyltransferase activity
I33_0948	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_0949	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_0950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_0951	COG0384	phenazine biosynthesis protein PhzF
I33_0952	COG0778	Nitroreductase
I33_0955	COG1090	epimerase
I33_0956	COG2137	regulation of response to DNA damage stimulus
I33_0958	COG2814	Major facilitator Superfamily
I33_0961	COG3103	Sh3 type 3 domain protein
I33_0962	COG5658	integral membrane protein
I33_0963	COG0463	Glycosyl transferase, family 2
I33_0964	COG4485	Bacterial membrane protein, YfhO
I33_0965	COG1988	membrane-bound metal-dependent
I33_0966	COG1194	a g-specific adenine glycosylase
I33_0968	COG1028	Short-chain dehydrogenase reductase Sdr
I33_0971	COG3557	Belongs to the UPF0374 family
I33_0972	COG1132	(ABC) transporter
I33_0973	COG4129	membrane
I33_0974	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I33_0975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I33_0976	COG0735	belongs to the Fur family
I33_0999	COG4326	sporulation control protein
I33_1001	COG5577	PFAM Coat F domain
I33_1002	COG3340	Belongs to the peptidase S51 family
I33_1003	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I33_1005	COG0753	catalase activity
I33_1006	COG1116	anion transmembrane transporter activity
I33_1007	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I33_1008	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I33_1009	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_1011	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I33_1013	COG1476	TRANSCRIPTIONal
I33_1015	COG3382	B3 4 domain protein
I33_1016	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I33_1018	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I33_1019	COG0789	Transcriptional regulator
I33_1020	COG1664	Polymer-forming cytoskeletal
I33_1021	COG1664	Polymer-forming cytoskeletal
I33_1024	COG2766	serine protein kinase
I33_1025	COG2718	Belongs to the UPF0229 family
I33_1026	COG1846	Transcriptional regulator
I33_1027	COG1566	PFAM secretion protein HlyD family protein
I33_1028	COG2814	Major facilitator Superfamily
I33_1029	COG0655	NAD(P)H dehydrogenase (quinone) activity
I33_1033	COG1725	Transcriptional regulator
I33_1034	COG1131	(ABC) transporter
I33_1035	COG1131	(ABC) transporter
I33_1036	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I33_1037	COG1278	Cold shock
I33_1038	COG1464	Belongs to the NlpA lipoprotein family
I33_1039	COG3706	GGDEF domain
I33_1040	COG1823	symporter activity
I33_1045	COG0737	Belongs to the 5'-nucleotidase family
I33_1045	COG1525	nuclease
I33_1045	COG4085	toxin activity
I33_1046	COG3764	Sortase (surface protein transpeptidase)
I33_1047	COG0564	pseudouridine synthase activity
I33_1049	COG0517	IMP dehydrogenase activity
I33_1050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I33_1051	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I33_1051	COG3153	acetyltransferase
I33_1053	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I33_1054	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I33_1055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I33_1056	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I33_1057	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I33_1058	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I33_1059	COG4585	Histidine kinase
I33_1059	COG2203	Gaf domain
I33_1060	COG2197	response regulator
I33_1061	COG0431	NADPH-dependent FMN reductase
I33_1064	COG0791	NLP P60 protein
I33_1064	COG1388	LysM domain
I33_1065	COG1959	2 iron, 2 sulfur cluster binding
I33_1066	COG0668	transmembrane transport
I33_1067	COG2719	SpoVR family
I33_1068	COG1785	Belongs to the alkaline phosphatase family
I33_1070	COG0791	NLP P60 protein
I33_1070	COG1388	LysM domain
I33_1071	COG0583	DNA-binding transcription factor activity
I33_1072	COG0372	Belongs to the citrate synthase family
I33_1073	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1074	COG0531	amino acid
I33_1075	COG0733	neurotransmitter:sodium symporter activity
I33_1076	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_1077	COG0456	acetyltransferase
I33_1080	COG1595	DNA-templated transcription, initiation
I33_1081	COG0667	Aldo Keto reductase
I33_1082	COG0204	Acyl-transferase
I33_1083	COG1253	flavin adenine dinucleotide binding
I33_1084	COG0789	Transcriptional regulator
I33_1085	COG0436	Aminotransferase
I33_1087	COG1253	flavin adenine dinucleotide binding
I33_1088	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I33_1089	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I33_1090	COG0584	glycerophosphoryl diester phosphodiesterase
I33_1092	COG0668	transmembrane transport
I33_1093	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I33_1094	COG0726	polysaccharide deacetylase
I33_1095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I33_1096	COG1757	Na H antiporter
I33_1097	COG0589	response to stress
I33_1099	COG1132	(ABC) transporter
I33_1100	COG1132	(ABC) transporter
I33_1101	COG0702	epimerase
I33_1105	COG0189	ligase activity
I33_1106	COG0189	ligase activity
I33_1107	COG4399	Belongs to the UPF0754 family
I33_1108	COG3679	Belongs to the UPF0342 family
I33_1109	COG4335	DNA alkylation repair
I33_1110	COG0561	phosphatase activity
I33_1111	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I33_1112	COG0475	glutathione-regulated potassium exporter activity
I33_1113	COG0490	domain, Protein
I33_1115	COG1024	Enoyl-CoA hydratase
I33_1117	COG4152	abc transporter atp-binding protein
I33_1118	COG1668	transmembrane transport
I33_1120	COG0420	3'-5' exonuclease activity
I33_1121	COG4717	serine-type aminopeptidase activity
I33_1122	COG3481	metal-dependent phosphohydrolase, HD sub domain
I33_1124	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I33_1129	COG1846	Transcriptional regulator
I33_1130	COG4980	gas vesicle protein
I33_1133	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I33_1134	COG0537	adenosine 5'-monophosphoramidase activity
I33_1135	COG1131	(ABC) transporter
I33_1136	COG4473	ABC transporter
I33_1138	COG1473	amidohydrolase
I33_1139	COG3069	C4-dicarboxylate transmembrane transporter activity
I33_1141	COG2329	Antibiotic biosynthesis monooxygenase
I33_1142	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I33_1143	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I33_1147	COG1309	transcriptional regulator
I33_1148	COG1511	domain protein
I33_1149	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I33_1150	COG4377	Putative membrane peptidase family (DUF2324)
I33_1152	COG1363	Peptidase, m42
I33_1153	COG4405	Protein conserved in bacteria
I33_1154	COG1301	dicarboxylic acid transport
I33_1156	COG1234	tRNA 3'-trailer cleavage
I33_1157	COG0095	Lipoate-protein ligase
I33_1158	COG0702	epimerase
I33_1159	COG0318	PFAM AMP-dependent synthetase and ligase
I33_1161	COG0501	Belongs to the peptidase M48B family
I33_1162	COG1404	Belongs to the peptidase S8 family
I33_1164	COG0456	acetyltransferase
I33_1165	COG0604	alcohol dehydrogenase
I33_1166	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I33_1167	COG0406	alpha-ribazole phosphatase activity
I33_1168	COG0183	Belongs to the thiolase family
I33_1169	COG0318	PFAM AMP-dependent synthetase and ligase
I33_1170	COG1268	BioY protein
I33_1171	COG0840	transmembrane signaling receptor activity
I33_1172	COG0723	plastoquinol--plastocyanin reductase activity
I33_1172	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I33_1173	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1175	COG4903	ComK protein
I33_1176	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1178	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_1181	COG0398	Pfam SNARE associated Golgi protein
I33_1182	COG0681	Belongs to the peptidase S26 family
I33_1183	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I33_1184	COG1846	Transcriptional regulator
I33_1186	COG0738	Major facilitator superfamily
I33_1187	COG0673	inositol 2-dehydrogenase activity
I33_1188	COG0561	phosphatase activity
I33_1189	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I33_1190	COG1609	Transcriptional regulator
I33_1191	COG3180	Ammonia monooxygenase
I33_1192	COG2814	Major facilitator Superfamily
I33_1192	COG0477	Major facilitator Superfamily
I33_1193	COG4533	DNA binding
I33_1196	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I33_1197	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I33_1198	COG1074	ATP-dependent DNA helicase activity
I33_1199	COG0420	3'-5' exonuclease activity
I33_1200	COG0419	ATPase involved in DNA repair
I33_1201	COG1403	HNH endonuclease
I33_1210	COG5337	Spore coat protein CotH
I33_1211	COG0179	Fumarylacetoacetate (FAA) hydrolase
I33_1213	COG1404	Belongs to the peptidase S8 family
I33_1215	COG0367	asparagine synthase
I33_1216	COG1562	ergosterol biosynthetic process
I33_1217	COG0534	Mate efflux family protein
I33_1218	COG2207	Transcriptional regulator
I33_1218	COG1917	Cupin 2, conserved barrel domain protein
I33_1219	COG1609	Transcriptional regulator
I33_1220	COG0673	inositol 2-dehydrogenase activity
I33_1221	COG2318	DinB family
I33_1222	COG1279	arginine transmembrane transporter activity
I33_1223	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_1224	COG1357	PFAM Pentapeptide repeats (8 copies)
I33_1225	COG2267	carboxylic ester hydrolase activity
I33_1226	COG0529	Catalyzes the synthesis of activated sulfate
I33_1227	COG2046	Belongs to the sulfate adenylyltransferase family
I33_1228	COG0175	sulfate reduction
I33_1229	COG2045	Belongs to the ComB family
I33_1230	COG1809	phosphosulfolactate synthase activity
I33_1231	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_1232	COG4948	Mandelate Racemase Muconate Lactonizing
I33_1233	COG2814	Major facilitator Superfamily
I33_1234	COG0454	-acetyltransferase
I33_1235	COG2153	protein acetylation
I33_1237	COG1666	GTP binding
I33_1238	COG2996	Protein conserved in bacteria
I33_1240	COG1307	EDD domain protein, DegV family
I33_1241	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_1245	COG0561	phosphatase activity
I33_1246	COG1073	alpha beta
I33_1247	COG2151	metal-sulfur cluster biosynthetic enzyme
I33_1249	COG0277	FAD linked oxidase domain protein
I33_1250	COG2271	Major facilitator Superfamily
I33_1251	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I33_1254	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I33_1255	COG0505	Belongs to the CarA family
I33_1256	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I33_1257	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I33_1260	COG2267	carboxylic ester hydrolase activity
I33_1262	COG1744	ABC transporter substrate-binding protein PnrA-like
I33_1265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I33_1266	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I33_1267	COG5504	Zn-dependent protease
I33_1268	COG0444	Belongs to the ABC transporter superfamily
I33_1269	COG4608	Belongs to the ABC transporter superfamily
I33_1271	COG0601	transmembrane transport
I33_1272	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I33_1274	COG0180	Tryptophanyl-tRNA synthetase
I33_1275	COG4166	transmembrane transport
I33_1276	COG0601	transmembrane transport
I33_1277	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I33_1278	COG0444	Belongs to the ABC transporter superfamily
I33_1279	COG4608	Belongs to the ABC transporter superfamily
I33_1280	COG2814	Major facilitator Superfamily
I33_1281	COG0456	acetyltransferase
I33_1282	COG1393	Belongs to the ArsC family
I33_1283	COG0861	Integral membrane protein TerC family
I33_1284	COG4862	establishment of competence for transformation
I33_1286	COG4469	Competence protein
I33_1287	COG1164	Oligoendopeptidase f
I33_1290	COG2346	COG2346, Truncated hemoglobins
I33_1291	COG0741	lytic transglycosylase activity
I33_1292	COG4116	CYTH
I33_1294	COG2357	RelA SpoT domain protein
I33_1295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I33_1296	COG0564	pseudouridine synthase activity
I33_1297	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I33_1298	COG0569	domain protein
I33_1298	COG0475	glutathione-regulated potassium exporter activity
I33_1299	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I33_1300	COG0352	thiamine-phosphate diphosphorylase activity
I33_1301	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I33_1302	COG2104	thiamine diphosphate biosynthetic process
I33_1303	COG2022	thiamine diphosphate biosynthetic process
I33_1304	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I33_1305	COG0351	phosphomethylpyrimidine kinase
I33_1306	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I33_1319	COG0210	DNA helicase
I33_1321	COG2153	protein acetylation
I33_1322	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I33_1323	COG2382	esterase
I33_1324	COG0626	cystathionine gamma-synthase activity
I33_1325	COG0626	cystathionine gamma-synthase activity
I33_1326	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_1329	COG0501	Belongs to the peptidase M48B family
I33_1330	COG5505	Protein of unknown function (DUF819)
I33_1337	COG4824	toxin secretion phage lysis holin
I33_1338	COG3409	Peptidoglycan-binding domain 1 protein
I33_1338	COG5632	N-Acetylmuramoyl-L-alanine amidase
I33_1347	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I33_1349	COG3711	transcriptional antiterminator
I33_1349	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_1350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_1350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I33_1350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I33_1351	COG1482	cell wall glycoprotein biosynthetic process
I33_1353	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_1355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I33_1359	COG0109	protoheme IX farnesyltransferase activity
I33_1361	COG0726	polysaccharide deacetylase
I33_1365	COG5504	Zn-dependent protease
I33_1366	COG2205	protein histidine kinase activity
I33_1368	COG3383	formate dehydrogenase (NAD+) activity
I33_1369	COG2427	Protein of unknown function (DUF1641)
I33_1371	COG1051	belongs to the nudix hydrolase family
I33_1373	COG2124	cytochrome p450
I33_1374	COG1819	glycosyl
I33_1376	COG1587	Uroporphyrinogen-III synthase
I33_1377	COG0390	transport system, permease component
I33_1378	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I33_1379	COG0697	spore germination
I33_1381	COG4297	protein containing double-stranded beta helix domain
I33_1384	COG1252	NADH dehydrogenase
I33_1385	COG1904	glucuronate isomerase
I33_1386	COG2211	Major facilitator Superfamily
I33_1387	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I33_1388	COG1063	alcohol dehydrogenase
I33_1389	COG1312	Catalyzes the dehydration of D-mannonate
I33_1390	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1391	COG2271	Major facilitator Superfamily
I33_1392	COG1609	Transcriptional regulator
I33_1393	COG0246	Mannitol dehydrogenase
I33_1394	COG2721	sulfolactate sulfo-lyase activity
I33_1395	COG0730	response to heat
I33_1396	COG2318	DinB family
I33_1397	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I33_1398	COG0457	Tetratricopeptide repeat
I33_1400	COG2350	Protein conserved in bacteria
I33_1401	COG5632	N-Acetylmuramoyl-L-alanine amidase
I33_1401	COG3409	Peptidoglycan-binding domain 1 protein
I33_1401	COG1388	LysM domain
I33_1403	COG4195	phage-related replication protein
I33_1404	COG3546	catalase activity
I33_1405	COG2856	Zn peptidase
I33_1406	COG1396	sequence-specific DNA binding
I33_1408	COG1522	sequence-specific DNA binding
I33_1409	COG1484	DNA-dependent DNA replication
I33_1413	COG1595	DNA-templated transcription, initiation
I33_1414	COG3728	DNA packaging
I33_1414	COG5484	DNA packaging
I33_1415	COG1783	phage Terminase large subunit
I33_1416	COG5518	Phage portal protein
I33_1417	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I33_1418	COG4653	Phage capsid family
I33_1427	COG5412	phage tail tape measure protein
I33_1427	COG3953	SLT domain
I33_1428	COG1652	LysM domain
I33_1429	COG4193	domain, Protein
I33_1431	COG3628	GPW Gp25 family protein
I33_1432	COG3299	homolog of phage Mu protein gp47
I33_1433	COG3778	Protein conserved in bacteria
I33_1441	COG5632	N-Acetylmuramoyl-L-alanine amidase
I33_1441	COG3409	Peptidoglycan-binding domain 1 protein
I33_1445	COG0306	phosphate transporter
I33_1446	COG1392	Phosphate transport regulator
I33_1447	COG0531	amino acid
I33_1449	COG0346	lactoylglutathione lyase activity
I33_1450	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I33_1451	COG0463	Glycosyl transferase, family 2
I33_1452	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I33_1453	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I33_1454	COG2362	D-Aminopeptidase
I33_1455	COG0601	transmembrane transport
I33_1456	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I33_1457	COG0444	Belongs to the ABC transporter superfamily
I33_1458	COG4166	transmembrane transport
I33_1460	COG1619	proteins homologs of microcin C7 resistance protein MccF
I33_1461	COG4948	Mandelate Racemase Muconate Lactonizing
I33_1462	COG0791	NLP P60 protein
I33_1463	COG4608	Belongs to the ABC transporter superfamily
I33_1464	COG2706	6-phosphogluconolactonase activity
I33_1465	COG1834	amidinotransferase
I33_1466	COG1607	acyl-coa hydrolase
I33_1467	COG1017	nitric oxide dioxygenase activity
I33_1467	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I33_1469	COG2323	membrane
I33_1470	COG2318	DinB family
I33_1471	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_1472	COG2076	Multidrug Resistance protein
I33_1473	COG2076	Multidrug Resistance protein
I33_1474	COG0788	formyltetrahydrofolate deformylase activity
I33_1475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I33_1476	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I33_1477	COG1764	response to oxidative stress
I33_1478	COG1846	Transcriptional regulator
I33_1479	COG1764	response to oxidative stress
I33_1481	COG0590	tRNA wobble adenosine to inosine editing
I33_1483	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I33_1485	COG1404	Belongs to the peptidase S8 family
I33_1487	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_1488	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I33_1489	COG1122	ATPase activity
I33_1490	COG4721	ABC-type cobalt transport system, permease component
I33_1492	COG0745	RESPONSE REGULATOR receiver
I33_1494	COG3212	peptidase
I33_1495	COG3212	peptidase
I33_1498	COG2239	Acts as a magnesium transporter
I33_1499	COG0789	Transcriptional regulator
I33_1502	COG1846	Transcriptional regulator
I33_1503	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I33_1504	COG0726	polysaccharide deacetylase
I33_1505	COG1408	metallophosphoesterase
I33_1507	COG0463	Glycosyl transferase, family 2
I33_1508	COG1793	dna ligase
I33_1508	COG3285	dna ligase
I33_1509	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I33_1510	COG5001	Diguanylate cyclase
I33_1510	COG3300	MHYT domain
I33_1512	COG0586	Pfam SNARE associated Golgi protein
I33_1513	COG0861	Integral membrane protein TerC family
I33_1514	COG1191	sigma factor activity
I33_1518	COG0501	Belongs to the peptidase M48B family
I33_1519	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I33_1522	COG3594	Acyltransferase
I33_1523	COG5002	protein histidine kinase activity
I33_1524	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I33_1526	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I33_1527	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I33_1528	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I33_1529	COG0436	Aminotransferase
I33_1530	COG1850	ribulose-bisphosphate carboxylase activity
I33_1531	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
I33_1532	COG0235	Class ii aldolase
I33_1533	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I33_1534	COG3339	Conserved Protein
I33_1537	COG3852	Histidine kinase
I33_1538	COG1846	Transcriptional regulator
I33_1539	COG1360	Flagellar Motor Protein
I33_1540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I33_1541	COG0542	response to heat
I33_1542	COG3949	Membrane
I33_1543	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I33_1544	COG0720	synthase
I33_1545	COG0602	queuosine metabolic process
I33_1546	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I33_1548	COG1733	regulation of RNA biosynthetic process
I33_1549	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1551	COG1388	LysM domain
I33_1552	COG3858	chitin binding
I33_1555	COG4873	Protein conserved in bacteria
I33_1558	COG3773	Cell wall hydrolase
I33_1559	COG2244	polysaccharide biosynthetic process
I33_1560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_1561	COG2217	Heavy metal translocating P-type atpase
I33_1563	COG0006	proline dipeptidase activity
I33_1565	COG1609	Transcriptional regulator
I33_1566	COG3711	transcriptional antiterminator
I33_1567	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_1567	COG1263	PTS System
I33_1567	COG2190	(PTS) system
I33_1568	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_1569	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I33_1571	COG1533	DNA photolyase activity
I33_1572	COG0456	acetyltransferase
I33_1573	COG0840	transmembrane signaling receptor activity
I33_1574	COG2084	Dehydrogenase
I33_1575	COG2340	Cysteine-rich secretory protein family
I33_1576	COG0768	penicillin binding
I33_1577	COG4191	Histidine kinase
I33_1578	COG0436	Aminotransferase
I33_1580	COG0835	chemotaxis
I33_1580	COG0784	Response regulator, receiver
I33_1582	COG2814	Major facilitator Superfamily
I33_1583	COG1376	ErfK ybiS ycfS ynhG family protein
I33_1584	COG1408	metallophosphoesterase
I33_1585	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1586	COG2200	EAL domain
I33_1588	COG4703	Protein of unknown function (DUF1797)
I33_1589	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I33_1591	COG0517	IMP dehydrogenase activity
I33_1592	COG0583	DNA-binding transcription factor activity
I33_1593	COG0716	FMN binding
I33_1595	COG0716	FMN binding
I33_1596	COG2171	N-acyltransferase activity
I33_1597	COG1473	amidohydrolase
I33_1599	COG0668	transmembrane transport
I33_1600	COG0450	alkyl hydroperoxide reductase
I33_1601	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_1604	COG0746	molybdenum cofactor guanylyltransferase activity
I33_1605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I33_1606	COG0303	'Molybdopterin
I33_1607	COG1763	Mo-molybdopterin cofactor biosynthetic process
I33_1608	COG0314	molybdopterin synthase activity
I33_1609	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I33_1610	COG1132	(ABC) transporter
I33_1611	COG1132	(ABC) transporter
I33_1613	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I33_1614	COG1136	(ABC) transporter
I33_1615	COG0577	efflux transmembrane transporter activity
I33_1616	COG1349	DNA-binding transcription factor activity
I33_1617	COG1105	Belongs to the carbohydrate kinase PfkB family
I33_1618	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_1618	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I33_1618	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I33_1619	COG0681	Belongs to the peptidase S26 family
I33_1621	COG0488	(ABC) transporter
I33_1622	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I33_1623	COG2309	aminopeptidase activity
I33_1625	COG1077	Cell shape determining protein MreB Mrl
I33_1626	COG2002	toxin-antitoxin pair type II binding
I33_1627	COG3852	Histidine kinase
I33_1628	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I33_1628	COG2105	PFAM AIG2 family protein
I33_1629	COG0569	domain protein
I33_1630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I33_1631	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I33_1634	COG0561	phosphatase activity
I33_1635	COG0242	peptide deformylase activity
I33_1637	COG0497	DNA recombination
I33_1638	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I33_1639	COG0022	dehydrogenase e1 component
I33_1640	COG0508	dehydrogenase complex catalyzes the overall conversion of
I33_1641	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I33_1642	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_1644	COG1982	Orn Lys Arg decarboxylase major
I33_1645	COG4476	Belongs to the UPF0223 family
I33_1646	COG4493	Belongs to the UPF0637 family
I33_1649	COG0483	inositol monophosphate 1-phosphatase activity
I33_1651	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I33_1655	COG1595	DNA-templated transcription, initiation
I33_1661	COG4896	Protein conserved in bacteria
I33_1663	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I33_1664	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I33_1665	COG2066	Belongs to the glutaminase family
I33_1666	COG4838	Belongs to the UPF0358 family
I33_1667	COG0772	Belongs to the SEDS family
I33_1668	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I33_1669	COG1612	heme a metabolic process
I33_1671	COG0109	protoheme IX farnesyltransferase activity
I33_1673	COG2010	Cytochrome c
I33_1673	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I33_1674	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I33_1675	COG1845	cytochrome c oxidase, subunit III
I33_1676	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I33_1677	COG3336	cytochrome c oxidase
I33_1679	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I33_1680	COG2340	Cysteine-rich secretory protein family
I33_1683	COG3679	Belongs to the UPF0342 family
I33_1684	COG4471	UPF0298 protein
I33_1686	COG0742	ribosomal rna small subunit methyltransferase
I33_1687	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I33_1688	COG3314	Sporulation integral membrane protein YlbJ
I33_1689	COG1752	Esterase of the alpha-beta hydrolase superfamily
I33_1690	COG3480	Lon protease (S16) C-terminal proteolytic domain
I33_1691	COG1323	Belongs to the UPF0348 family
I33_1693	COG1399	metal-binding, possibly nucleic acid-binding protein
I33_1696	COG0454	-acetyltransferase
I33_1697	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I33_1698	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I33_1699	COG2001	Belongs to the MraZ family
I33_1700	COG0275	rRNA processing
I33_1701	COG4839	cell division protein FtsL
I33_1703	COG0768	penicillin binding
I33_1704	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I33_1705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I33_1706	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I33_1707	COG0772	Belongs to the SEDS family
I33_1708	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I33_1709	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I33_1710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I33_1711	COG3879	Bacterial protein of unknown function (DUF881)
I33_1712	COG3879	Bacterial protein of unknown function (DUF881)
I33_1713	COG3856	small basic protein
I33_1714	COG0849	cell division
I33_1715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I33_1716	COG1404	Belongs to the peptidase S8 family
I33_1716	COG4412	M6 family metalloprotease domain protein
I33_1718	COG1191	sigma factor activity
I33_1719	COG1191	sigma factor activity
I33_1720	COG1119	ATPase activity
I33_1721	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I33_1722	COG1873	PFAM PRC-barrel domain
I33_1724	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I33_1725	COG1799	cell septum assembly
I33_1726	COG0762	integral membrane protein
I33_1727	COG2302	S4 RNA-binding domain
I33_1728	COG3599	regulation of cell shape
I33_1731	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I33_1732	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I33_1733	COG0564	pseudouridine synthase activity
I33_1734	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I33_1735	COG2233	PERMEase
I33_1736	COG0540	Belongs to the ATCase OTCase family
I33_1737	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I33_1738	COG0505	Belongs to the CarA family
I33_1739	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I33_1740	COG0543	2 iron, 2 sulfur cluster binding
I33_1741	COG0167	dihydroorotate dehydrogenase activity
I33_1742	COG0284	orotidine-5'-phosphate decarboxylase activity
I33_1743	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I33_1744	COG0175	sulfate reduction
I33_1745	COG0306	phosphate transporter
I33_1746	COG2046	Belongs to the sulfate adenylyltransferase family
I33_1747	COG0529	Catalyzes the synthesis of activated sulfate
I33_1748	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I33_1749	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I33_1750	COG1648	precorrin-2 dehydrogenase activity
I33_1752	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I33_1753	COG1561	YicC-like family, N-terminal region
I33_1754	COG2052	Domain of unknown function (DUF370)
I33_1755	COG0194	GDP metabolic process
I33_1756	COG1758	RNA polymerase activity
I33_1757	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I33_1758	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I33_1759	COG0242	peptide deformylase activity
I33_1760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I33_1761	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I33_1761	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I33_1762	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I33_1763	COG0631	protein serine/threonine phosphatase activity
I33_1764	COG0515	serine threonine protein kinase
I33_1764	COG2815	serine threonine protein kinase
I33_1765	COG1162	GTPase activity
I33_1766	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I33_1767	COG1564	THIamine pyrophosphokinase
I33_1768	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I33_1769	COG1302	Protein conserved in bacteria
I33_1770	COG1461	Dihydroxyacetone kinase
I33_1771	COG1760	l-serine dehydratase
I33_1772	COG1760	l-serine dehydratase
I33_1773	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I33_1774	COG1349	DNA-binding transcription factor activity
I33_1774	COG2050	protein possibly involved in aromatic compounds catabolism
I33_1775	COG0416	fatty acid biosynthetic process
I33_1776	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I33_1777	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1778	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_1779	COG0571	ribonuclease III activity
I33_1780	COG1196	nuclear chromosome segregation
I33_1781	COG0552	protein localization to endoplasmic reticulum
I33_1783	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I33_1784	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I33_1785	COG0228	four-way junction DNA binding
I33_1786	COG1837	Belongs to the UPF0109 family
I33_1788	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I33_1789	COG0336	Belongs to the RNA methyltransferase TrmD family
I33_1790	COG0335	large ribosomal subunit rRNA binding
I33_1791	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I33_1792	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I33_1794	COG2257	FlhB HrpN YscU SpaS Family
I33_1795	COG0045	succinate-CoA ligase (ADP-forming) activity
I33_1796	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I33_1797	COG0758	DNA mediated transformation
I33_1798	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I33_1799	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I33_1800	COG4974	Belongs to the 'phage' integrase family
I33_1801	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I33_1802	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I33_1803	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I33_1804	COG1815	bacterial-type flagellum-dependent cell motility
I33_1805	COG1558	bacterial-type flagellum-dependent cell motility
I33_1806	COG1677	Flagellar hook-basal body complex protein FliE
I33_1807	COG1766	The M ring may be actively involved in energy transduction
I33_1808	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I33_1809	COG1317	bacterial-type flagellum organization
I33_1810	COG1157	protein secretion by the type III secretion system
I33_1811	COG2882	bacterial-type flagellum organization
I33_1812	COG3334	PFAM MgtE intracellular
I33_1813	COG3144	bacterial-type flagellum assembly
I33_1814	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I33_1815	COG4786	Flagellar basal body rod
I33_1816	COG1582	Flagellar protein (FlbD)
I33_1817	COG1580	Controls the rotational direction of flagella during chemotaxis
I33_1818	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I33_1819	COG1776	CheC inhibitor of MCP methylation
I33_1819	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I33_1820	COG2201	protein-glutamate methylesterase activity
I33_1821	COG3190	flagellar
I33_1822	COG1338	Plays a role in the flagellum-specific transport system
I33_1823	COG1987	bacterial-type flagellum assembly
I33_1824	COG1684	flagellar biosynthetic protein fliR
I33_1825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I33_1826	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I33_1827	COG1419	protein localization to endoplasmic reticulum
I33_1828	COG0455	bacterial-type flagellum organization
I33_1829	COG2201	protein-glutamate methylesterase activity
I33_1830	COG0643	Histidine kinase
I33_1830	COG2198	Histidine kinase
I33_1831	COG0835	chemotaxis
I33_1832	COG1776	CheC inhibitor of MCP methylation
I33_1833	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I33_1834	COG1191	sigma factor activity
I33_1836	COG0052	Belongs to the universal ribosomal protein uS2 family
I33_1837	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I33_1838	COG0528	UMP kinase activity
I33_1839	COG0233	cytoplasmic translational termination
I33_1840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I33_1841	COG4589	Belongs to the CDS family
I33_1842	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I33_1843	COG0750	zinc metalloprotease
I33_1844	COG0442	prolyl-tRNA aminoacylation
I33_1845	COG2176	DNA-directed DNA polymerase activity
I33_1846	COG0779	Required for maturation of 30S ribosomal subunits
I33_1847	COG0195	Participates in both transcription termination and antitermination
I33_1848	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I33_1849	COG1358	cellular component organization or biogenesis
I33_1850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I33_1851	COG1550	Protein conserved in bacteria
I33_1852	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I33_1853	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I33_1854	COG0196	riboflavin kinase activity
I33_1855	COG1185	polyribonucleotide nucleotidyltransferase activity
I33_1856	COG0726	polysaccharide deacetylase
I33_1857	COG0612	Peptidase, M16
I33_1858	COG1873	PFAM PRC-barrel domain
I33_1860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I33_1861	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I33_1862	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I33_1863	COG0527	aspartate kinase activity
I33_1864	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I33_1865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I33_1866	COG0740	serine-type endopeptidase activity
I33_1868	COG4980	gas vesicle protein
I33_1868	COG1674	ftsk spoiiie
I33_1869	COG2188	Transcriptional regulator
I33_1871	COG2814	Major facilitator Superfamily
I33_1872	COG0612	Peptidase, M16
I33_1873	COG0612	Peptidase, M16
I33_1874	COG0300	oxidoreductase activity
I33_1877	COG1426	Protein conserved in bacteria
I33_1878	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I33_1879	COG1546	Belongs to the CinA family
I33_1879	COG1058	Belongs to the CinA family
I33_1880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I33_1881	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I33_1882	COG1418	mRNA catabolic process
I33_1883	COG1692	metallophosphoesterase
I33_1884	COG2359	stage V sporulation protein S
I33_1885	COG1063	alcohol dehydrogenase
I33_1886	COG0156	8-amino-7-oxononanoate synthase activity
I33_1887	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I33_1888	COG4550	Control of competence regulator ComK, YlbF/YmcA
I33_1890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I33_1891	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I33_1894	COG3226	Transcriptional regulator
I33_1895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_1896	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I33_1898	COG3321	synthase
I33_1899	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I33_1899	COG2070	2-Nitropropane dioxygenase
I33_1900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_1901	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I33_1902	COG3425	synthase
I33_1903	COG1024	Enoyl-CoA hydratase
I33_1904	COG1024	Enoyl-CoA hydratase
I33_1905	COG0300	oxidoreductase activity
I33_1905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_1905	COG0318	PFAM AMP-dependent synthetase and ligase
I33_1905	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1905	COG3321	synthase
I33_1906	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_1906	COG0300	oxidoreductase activity
I33_1906	COG3321	synthase
I33_1906	COG4221	oxidoreductase activity
I33_1907	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_1907	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I33_1907	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_1907	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1907	COG3321	synthase
I33_1908	COG1028	Short-chain dehydrogenase reductase Sdr
I33_1908	COG3321	synthase
I33_1908	COG4221	oxidoreductase activity
I33_1908	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_1909	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I33_1909	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_1909	COG3321	synthase
I33_1909	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I33_1910	COG2124	cytochrome p450
I33_1912	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_1914	COG1404	Belongs to the peptidase S8 family
I33_1917	COG4195	phage-related replication protein
I33_1918	COG1764	response to oxidative stress
I33_1919	COG2076	Multidrug Resistance protein
I33_1920	COG2076	Multidrug Resistance protein
I33_1924	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I33_1925	COG1923	regulation of RNA biosynthetic process
I33_1928	COG1780	Probably involved in ribonucleotide reductase function
I33_1929	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I33_1930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I33_1931	COG4112	unkown
I33_1932	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_1935	COG0464	growth
I33_1936	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I33_1937	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I33_1938	COG0789	Transcriptional regulator
I33_1939	COG0174	glutamine synthetase
I33_1943	COG4824	toxin secretion phage lysis holin
I33_1952	COG4282	regulation of fungal-type cell wall biogenesis
I33_1955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_1962	COG2211	Major facilitator Superfamily
I33_1963	COG3507	Belongs to the glycosyl hydrolase 43 family
I33_1964	COG1940	carbohydrate kinase activity
I33_1965	COG2115	Belongs to the xylose isomerase family
I33_1966	COG1070	Carbohydrate kinase
I33_1967	COG1525	nuclease
I33_1968	COG2814	Major facilitator Superfamily
I33_1969	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I33_1972	COG0756	dUTP diphosphatase activity
I33_1975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I33_1979	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I33_1982	COG3832	glyoxalase III activity
I33_1987	COG0531	amino acid
I33_1994	COG4195	phage-related replication protein
I33_1996	COG0346	lactoylglutathione lyase activity
I33_1997	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I33_1998	COG1388	LysM domain
I33_1999	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I33_2000	COG4224	UPF0291 protein
I33_2001	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I33_2003	COG3763	UPF0154 protein
I33_2005	COG0785	Cytochrome C biogenesis protein
I33_2006	COG2201	protein-glutamate methylesterase activity
I33_2007	COG4846	Membrane protein involved in cytochrome C biogenesis
I33_2009	COG0071	Belongs to the small heat shock protein (HSP20) family
I33_2012	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I33_2013	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_2017	COG0824	Thioesterase
I33_2019	COG4841	protein insertion into membrane
I33_2020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I33_2022	COG1832	CoA-binding protein
I33_2024	COG0187	DNA topoisomerase II activity
I33_2025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I33_2030	COG1115	amino acid carrier protein
I33_2031	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I33_2033	COG5520	Belongs to the glycosyl hydrolase 30 family
I33_2034	COG3507	Belongs to the glycosyl hydrolase 43 family
I33_2035	COG2246	polysaccharide biosynthetic process
I33_2036	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I33_2037	COG0586	Pfam SNARE associated Golgi protein
I33_2038	COG2404	hydrolase activity, acting on ester bonds
I33_2039	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I33_2040	COG1024	Enoyl-CoA hydratase
I33_2041	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I33_2042	COG0511	ligase activity, forming carbon-carbon bonds
I33_2043	COG0439	Biotin carboxylase
I33_2044	COG0318	PFAM AMP-dependent synthetase and ligase
I33_2045	COG1960	acyl-CoA dehydrogenase activity
I33_2047	COG1309	transcriptional regulator
I33_2049	COG1649	PFAM Uncharacterised BCR, COG1649
I33_2051	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_2051	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I33_2052	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_2053	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_2054	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_2055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_2056	COG2027	D-alanyl-D-alanine carboxypeptidase
I33_2057	COG2017	converts alpha-aldose to the beta-anomer
I33_2058	COG0534	Mate efflux family protein
I33_2061	COG0582	viral genome integration into host DNA
I33_2062	COG0166	Belongs to the GPI family
I33_2063	COG0405	Gamma-glutamyltransferase
I33_2064	COG0583	DNA-binding transcription factor activity
I33_2065	COG0604	alcohol dehydrogenase
I33_2066	COG0493	'glutamate synthase
I33_2067	COG0067	glutamate synthase
I33_2067	COG0069	glutamate synthase activity
I33_2067	COG0070	glutamate synthase
I33_2068	COG0583	DNA-binding transcription factor activity
I33_2069	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I33_2070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I33_2073	COG0300	oxidoreductase activity
I33_2074	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I33_2076	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_2077	COG2814	Major facilitator Superfamily
I33_2078	COG1070	Carbohydrate kinase
I33_2079	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I33_2080	COG0243	molybdopterin cofactor binding
I33_2082	COG0673	inositol 2-dehydrogenase activity
I33_2083	COG1082	Xylose isomerase domain protein TIM barrel
I33_2085	COG1609	Transcriptional regulator
I33_2089	COG5278	phosphoserine phosphatase activity
I33_2089	COG0840	transmembrane signaling receptor activity
I33_2090	COG2368	4-hydroxyphenylacetate
I33_2091	COG4305	rare lipoprotein A
I33_2092	COG3619	membrane
I33_2093	COG3866	Pectate lyase
I33_2094	COG2135	peptidase activity
I33_2097	COG2140	Oxalate decarboxylase
I33_2101	COG2720	vancomycin resistance protein
I33_2103	COG3655	Transcriptional regulator
I33_2104	COG3739	integral membrane protein
I33_2105	COG0583	DNA-binding transcription factor activity
I33_2106	COG0697	spore germination
I33_2108	COG0693	protein deglycase activity
I33_2109	COG2367	Beta-lactamase
I33_2112	COG0574	Belongs to the PEP-utilizing enzyme family
I33_2112	COG3848	Pyruvate phosphate dikinase
I33_2113	COG0726	polysaccharide deacetylase
I33_2115	COG2314	TM2 domain
I33_2116	COG1396	sequence-specific DNA binding
I33_2121	COG2135	peptidase activity
I33_2123	COG2135	peptidase activity
I33_2124	COG0583	DNA-binding transcription factor activity
I33_2132	COG0457	Tetratricopeptide repeat
I33_2133	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I33_2134	COG5444	nuclease activity
I33_2135	COG4282	regulation of fungal-type cell wall biogenesis
I33_2136	COG1231	oxidoreductase activity
I33_2137	COG5434	Belongs to the glycosyl hydrolase 28 family
I33_2138	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_2139	COG0662	Cupin 2, conserved barrel domain protein
I33_2139	COG2207	Transcriptional regulator
I33_2140	COG0456	acetyltransferase
I33_2141	COG1309	transcriptional regulator
I33_2142	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_2143	COG3708	Transcriptional regulator
I33_2144	COG2378	regulation of single-species biofilm formation
I33_2146	COG0640	Transcriptional regulator
I33_2147	COG0741	lytic transglycosylase activity
I33_2148	COG2322	membrane
I33_2151	COG1619	proteins homologs of microcin C7 resistance protein MccF
I33_2152	COG3239	Fatty acid desaturase
I33_2153	COG4585	Histidine kinase
I33_2154	COG2197	response regulator
I33_2156	COG3584	3D domain protein
I33_2156	COG1388	LysM domain
I33_2157	COG0514	ATP-dependent DNA helicase (RecQ)
I33_2160	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I33_2161	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I33_2164	COG0071	Belongs to the small heat shock protein (HSP20) family
I33_2169	COG1012	belongs to the aldehyde dehydrogenase family
I33_2170	COG1657	PFAM Prenyltransferase squalene oxidase
I33_2171	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I33_2172	COG0733	neurotransmitter:sodium symporter activity
I33_2173	COG0385	Bile acid
I33_2174	COG0508	dehydrogenase complex catalyzes the overall conversion of
I33_2175	COG0567	Dehydrogenase, E1 component
I33_2176	COG4548	von Willebrand factor, type A
I33_2177	COG0714	Associated with various cellular activities
I33_2178	COG2032	superoxide dismutase activity
I33_2179	COG0791	NLP P60 protein
I33_2179	COG1388	LysM domain
I33_2180	COG1819	glycosyl
I33_2181	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I33_2182	COG0534	Mate efflux family protein
I33_2183	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_2184	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I33_2185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I33_2187	COG2962	Rard protein
I33_2190	COG2610	gluconate transmembrane transporter activity
I33_2191	COG1942	4-Oxalocrotonate Tautomerase
I33_2193	COG1733	regulation of RNA biosynthetic process
I33_2194	COG0778	Nitroreductase
I33_2195	COG0400	carboxylic ester hydrolase activity
I33_2196	COG0346	lactoylglutathione lyase activity
I33_2198	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_2199	COG3409	Peptidoglycan-binding domain 1 protein
I33_2199	COG0793	Belongs to the peptidase S41A family
I33_2200	COG2226	methyltransferase
I33_2202	COG1876	peptidase activity
I33_2203	COG0813	purine-nucleoside phosphorylase activity
I33_2206	COG0671	phosphoesterase, PA-phosphatase related
I33_2210	COG4479	Belongs to the UPF0346 family
I33_2212	COG1509	lysine 2,3-aminomutase activity
I33_2213	COG0456	acetyltransferase
I33_2214	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I33_2215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I33_2216	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I33_2217	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I33_2219	COG0456	acetyltransferase
I33_2220	COG0463	Glycosyl transferase, family 2
I33_2223	COG4641	Protein conserved in bacteria
I33_2224	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
I33_2225	COG1086	Polysaccharide biosynthesis protein
I33_2226	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I33_2227	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I33_2228	COG1846	Transcriptional regulator
I33_2229	COG0534	Mate efflux family protein
I33_2231	COG4698	Protein conserved in bacteria
I33_2232	COG2755	lipolytic protein G-D-S-L family
I33_2233	COG1999	signal sequence binding
I33_2235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I33_2236	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I33_2237	COG1272	protein, Hemolysin III
I33_2238	COG0204	Acyl-transferase
I33_2239	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I33_2240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I33_2242	COG2136	Putative SAM-dependent methyltransferase
I33_2242	COG2521	methyltransferase
I33_2244	COG0129	dihydroxy-acid dehydratase activity
I33_2246	COG1413	lyase activity
I33_2247	COG1418	mRNA catabolic process
I33_2248	COG0386	Belongs to the glutathione peroxidase family
I33_2249	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I33_2251	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I33_2252	COG1278	Cold shock
I33_2256	COG0328	RNA-DNA hybrid ribonuclease activity
I33_2257	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I33_2258	COG0328	RNA-DNA hybrid ribonuclease activity
I33_2260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I33_2263	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I33_2264	COG1755	Isoprenylcysteine carboxyl methyltransferase
I33_2265	COG3424	synthase
I33_2266	COG2233	PERMEase
I33_2267	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I33_2268	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I33_2270	COG0800	Aldolase
I33_2271	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_2272	COG1609	Transcriptional regulator
I33_2273	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I33_2274	COG1028	Short-chain dehydrogenase reductase Sdr
I33_2275	COG1199	ATP-dependent helicase activity
I33_2277	COG0116	Belongs to the methyltransferase superfamily
I33_2279	COG4474	Belongs to the UPF0398 family
I33_2281	COG3359	exonuclease
I33_2282	COG1111	helicase
I33_2282	COG1205	dead DEAH box helicase
I33_2283	COG2190	(PTS) system
I33_2284	COG0071	Belongs to the small heat shock protein (HSP20) family
I33_2291	COG3331	DNA recombination
I33_2292	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I33_2292	COG4499	WXG100 protein secretion system (Wss), protein YukC
I33_2294	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I33_2295	COG3935	DnaD domain protein
I33_2296	COG0017	Asparaginyl-tRNA synthetase
I33_2297	COG0436	Aminotransferase
I33_2298	COG5353	protein conserved in bacteria
I33_2300	COG1199	ATP-dependent helicase activity
I33_2300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I33_2301	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I33_2302	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I33_2303	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I33_2304	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I33_2304	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I33_2305	COG0617	tRNA 3'-terminal CCA addition
I33_2306	COG0438	transferase activity, transferring glycosyl groups
I33_2307	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I33_2308	COG1803	Methylglyoxal synthase
I33_2309	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I33_2310	COG1694	Mazg nucleotide pyrophosphohydrolase
I33_2311	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_2313	COG4347	Protein of unknown function (DUF1405)
I33_2314	COG2010	Cytochrome c
I33_2314	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I33_2315	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I33_2316	COG0723	plastoquinol--plastocyanin reductase activity
I33_2318	COG5582	Belongs to the UPF0302 family
I33_2319	COG0457	Tetratricopeptide repeat
I33_2320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I33_2321	COG0287	Prephenate dehydrogenase
I33_2323	COG0159	tryptophan synthase activity
I33_2324	COG0133	tryptophan synthase activity
I33_2325	COG0135	phosphoribosylanthranilate isomerase activity
I33_2327	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I33_2328	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I33_2329	COG4401	Chorismate mutase type I
I33_2330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I33_2331	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I33_2332	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I33_2333	COG0105	UTP biosynthetic process
I33_2334	COG0142	geranyltranstransferase activity
I33_2335	COG2226	methyltransferase
I33_2336	COG0142	geranyltranstransferase activity
I33_2338	COG0302	gtp cyclohydrolase
I33_2339	COG0776	regulation of translation
I33_2343	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I33_2344	COG1160	GTP binding
I33_2349	COG1304	FMN binding
I33_2350	COG0539	negative regulation of cytoplasmic translation
I33_2351	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I33_2353	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I33_2354	COG2959	enzyme of heme biosynthesis
I33_2355	COG3773	Cell wall hydrolase
I33_2355	COG3409	Peptidoglycan-binding domain 1 protein
I33_2357	COG2339	peptidase activity
I33_2359	COG0492	ferredoxin-NADP+ reductase activity
I33_2360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I33_2362	COG4862	establishment of competence for transformation
I33_2363	COG1408	metallophosphoesterase
I33_2365	COG1388	LysM domain
I33_2366	COG1266	CAAX protease self-immunity
I33_2367	COG0514	ATP-dependent DNA helicase (RecQ)
I33_2368	COG4955	Helix-turn-helix domain
I33_2369	COG1141	Ferredoxin
I33_2370	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I33_2372	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I33_2373	COG0710	3-dehydroquinate dehydratase activity
I33_2375	COG1595	DNA-templated transcription, initiation
I33_2376	COG5002	protein histidine kinase activity
I33_2377	COG0745	RESPONSE REGULATOR receiver
I33_2378	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I33_2379	COG1333	cytochrome c biogenesis protein
I33_2380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_2381	COG1187	pseudouridine synthase activity
I33_2382	COG0700	Nucleoside recognition
I33_2383	COG2715	membrane protein required for spore maturation
I33_2384	COG1686	Belongs to the peptidase S11 family
I33_2386	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I33_2387	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I33_2388	COG1547	Domain of unknown function (DUF309)
I33_2389	COG0456	acetyltransferase
I33_2390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I33_2391	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I33_2391	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I33_2392	COG0307	riboflavin synthase, alpha
I33_2393	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I33_2393	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I33_2396	COG0681	Belongs to the peptidase S26 family
I33_2398	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I33_2402	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I33_2405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I33_2406	COG4086	secreted protein
I33_2407	COG0019	diaminopimelate decarboxylase activity
I33_2408	COG0697	spore germination
I33_2411	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I33_2415	COG1191	sigma factor activity
I33_2416	COG2172	sigma factor antagonist activity
I33_2417	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_2421	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I33_2422	COG4974	Belongs to the 'phage' integrase family
I33_2424	COG0735	belongs to the Fur family
I33_2425	COG1300	Membrane
I33_2428	COG0281	malic enzyme
I33_2429	COG1757	Na H antiporter
I33_2430	COG1027	Aspartate ammonia-lyase
I33_2431	COG0252	asparaginase activity
I33_2432	COG1396	sequence-specific DNA binding
I33_2433	COG1379	DNA repair
I33_2434	COG0494	nUDIX hydrolase
I33_2436	COG0667	Aldo Keto reductase
I33_2439	COG1073	alpha beta
I33_2441	COG4918	Iron-sulphur cluster biosynthesis
I33_2442	COG0456	acetyltransferase
I33_2442	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I33_2443	COG2329	Antibiotic biosynthesis monooxygenase
I33_2444	COG0456	acetyltransferase
I33_2446	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I33_2448	COG2211	Major facilitator Superfamily
I33_2450	COG0346	lactoylglutathione lyase activity
I33_2451	COG1072	(Pantothenic acid kinase))
I33_2452	COG3048	D-serine ammonia-lyase activity
I33_2453	COG0300	oxidoreductase activity
I33_2454	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_2455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I33_2456	COG4187	Peptidase family M20/M25/M40
I33_2457	COG1902	pentaerythritol trinitrate reductase activity
I33_2458	COG0596	Alpha beta hydrolase
I33_2460	COG1234	tRNA 3'-trailer cleavage
I33_2461	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I33_2463	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I33_2464	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I33_2466	COG0706	membrane insertase activity
I33_2467	COG3361	conserved protein (COG2071)
I33_2468	COG2195	Cleaves the N-terminal amino acid of tripeptides
I33_2469	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I33_2470	COG0346	lactoylglutathione lyase activity
I33_2471	COG1376	ErfK ybiS ycfS ynhG family protein
I33_2472	COG4129	membrane
I33_2473	COG1126	abc transporter atp-binding protein
I33_2474	COG0765	amino acid transport
I33_2475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_2478	COG1597	lipid kinase activity
I33_2479	COG2814	Major facilitator Superfamily
I33_2480	COG4978	Transcriptional regulator
I33_2480	COG0789	Transcriptional regulator
I33_2481	COG0508	dehydrogenase complex catalyzes the overall conversion of
I33_2482	COG0022	dehydrogenase e1 component
I33_2483	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I33_2484	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I33_2485	COG3426	butyrate kinase activity
I33_2486	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I33_2487	COG0280	phosphate acetyltransferase
I33_2488	COG3829	transcription factor binding
I33_2488	COG3290	protein histidine kinase activity
I33_2490	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I33_2491	COG2079	MmgE PrpD family protein
I33_2492	COG0372	Belongs to the citrate synthase family
I33_2493	COG1960	acyl-CoA dehydrogenase activity
I33_2494	COG1250	3-hydroxyacyl-CoA dehydrogenase
I33_2495	COG0183	Belongs to the thiolase family
I33_2496	COG0584	glycerophosphoryl diester phosphodiesterase
I33_2497	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_2500	COG1902	pentaerythritol trinitrate reductase activity
I33_2502	COG0745	RESPONSE REGULATOR receiver
I33_2503	COG0750	zinc metalloprotease
I33_2504	COG0497	DNA recombination
I33_2505	COG1438	arginine binding
I33_2506	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I33_2507	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I33_2508	COG0142	geranyltranstransferase activity
I33_2509	COG1722	exodeoxyribonuclease VII activity
I33_2510	COG1570	exodeoxyribonuclease VII activity
I33_2511	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I33_2512	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I33_2513	COG1302	Protein conserved in bacteria
I33_2514	COG0439	Biotin carboxylase
I33_2515	COG0511	ligase activity, forming carbon-carbon bonds
I33_2523	COG3854	ATPases associated with a variety of cellular activities
I33_2525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I33_2526	COG0006	proline dipeptidase activity
I33_2527	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I33_2529	COG3872	metal-dependent enzyme
I33_2531	COG1752	Esterase of the alpha-beta hydrolase superfamily
I33_2532	COG1321	iron dependent repressor
I33_2533	COG0095	Lipoate-protein ligase
I33_2534	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I33_2535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I33_2536	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I33_2537	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I33_2538	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I33_2541	COG1396	sequence-specific DNA binding
I33_2543	COG0681	Belongs to the peptidase S26 family
I33_2548	COG4940	Competence protein ComGF
I33_2550	COG4970	Tfp pilus assembly protein FimT
I33_2551	COG4537	Required for transformation and DNA binding
I33_2552	COG1459	type II secretion system
I33_2553	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I33_2555	COG0598	Magnesium transport protein CorA
I33_2556	COG1253	flavin adenine dinucleotide binding
I33_2557	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_2559	COG1393	Belongs to the ArsC family
I33_2561	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_2563	COG0011	TIGRFAM Protein of
I33_2565	COG2866	Carboxypeptidase
I33_2566	COG1368	sulfuric ester hydrolase activity
I33_2567	COG1940	carbohydrate kinase activity
I33_2568	COG4483	Protein conserved in bacteria
I33_2569	COG0705	Rhomboid family
I33_2569	COG0457	Tetratricopeptide repeat
I33_2571	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I33_2573	COG0438	transferase activity, transferring glycosyl groups
I33_2577	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I33_2578	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I33_2579	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I33_2580	COG0581	inorganic phosphate transmembrane transporter activity
I33_2581	COG0573	inorganic phosphate transmembrane transporter activity
I33_2582	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I33_2584	COG0477	Major facilitator Superfamily
I33_2585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I33_2586	COG2839	Protein conserved in bacteria
I33_2587	COG5521	maltodextrose utilization protein MalA
I33_2588	COG1388	LysM domain
I33_2589	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I33_2590	COG4709	membrane
I33_2591	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I33_2592	COG0735	belongs to the Fur family
I33_2593	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_2595	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I33_2596	COG0513	Belongs to the DEAD box helicase family
I33_2598	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I33_2599	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I33_2600	COG2384	SAM-dependent methyltransferase
I33_2601	COG2010	Cytochrome c
I33_2603	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I33_2604	COG0358	DNA primase activity
I33_2605	COG1671	Belongs to the UPF0178 family
I33_2607	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I33_2608	COG0517	IMP dehydrogenase activity
I33_2609	COG0751	glycine-tRNA ligase activity
I33_2610	COG0752	glycyl-tRNA synthetase alpha subunit
I33_2611	COG1381	Involved in DNA repair and RecF pathway recombination
I33_2613	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I33_2614	COG0295	cytidine deaminase activity
I33_2615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I33_2616	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I33_2617	COG1480	7TM receptor with intracellular HD hydrolase
I33_2618	COG1702	phosphate starvation-inducible protein PhoH
I33_2622	COG4864	UPF0365 protein
I33_2623	COG1030	water channel activity
I33_2624	COG1610	YqeY-like protein
I33_2625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I33_2626	COG1283	sodium-dependent phosphate transmembrane transporter activity
I33_2627	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I33_2628	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I33_2629	COG2264	protein methyltransferase activity
I33_2630	COG0484	heat shock protein binding
I33_2631	COG0443	Heat shock 70 kDa protein
I33_2632	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I33_2633	COG1420	regulation of RNA biosynthetic process
I33_2634	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I33_2635	COG0481	GTPase activity
I33_2637	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_2638	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I33_2639	COG0268	Binds directly to 16S ribosomal RNA
I33_2640	COG1466	dna polymerase III delta subunit
I33_2643	COG2333	competence protein COMEC
I33_2643	COG0658	competence protein
I33_2645	COG2131	deaminase
I33_2646	COG1596	polysaccharide export
I33_2646	COG1555	photosystem II stabilization
I33_2647	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I33_2648	COG2226	methyltransferase
I33_2649	COG0799	negative regulation of ribosome biogenesis
I33_2650	COG1713	HD superfamily hydrolase involved in NAD metabolism
I33_2651	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I33_2652	COG1534	Rna-binding protein
I33_2653	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I33_2654	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I33_2655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I33_2657	COG2755	lipolytic protein G-D-S-L family
I33_2659	COG5632	N-Acetylmuramoyl-L-alanine amidase
I33_2659	COG3409	Peptidoglycan-binding domain 1 protein
I33_2660	COG0398	Pfam SNARE associated Golgi protein
I33_2661	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I33_2663	COG3209	COG3209 Rhs family protein
I33_2668	COG1309	transcriptional regulator
I33_2671	COG4221	oxidoreductase activity
I33_2672	COG2814	Major facilitator Superfamily
I33_2675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I33_2676	COG0656	L-ascorbic acid biosynthetic process
I33_2680	COG0457	Tetratricopeptide repeat
I33_2684	COG5444	nuclease activity
I33_2689	COG4282	regulation of fungal-type cell wall biogenesis
I33_2697	COG4978	Transcriptional regulator
I33_2697	COG0789	Transcriptional regulator
I33_2698	COG2814	Major facilitator Superfamily
I33_2699	COG0456	acetyltransferase
I33_2700	COG1253	flavin adenine dinucleotide binding
I33_2706	COG2732	(Barnase) inhibitor
I33_2707	COG2124	cytochrome p450
I33_2709	COG1335	isochorismatase
I33_2711	COG2318	DinB family
I33_2713	COG2070	2-Nitropropane dioxygenase
I33_2715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I33_2716	COG0673	inositol 2-dehydrogenase activity
I33_2718	COG1733	regulation of RNA biosynthetic process
I33_2723	COG4978	Transcriptional regulator
I33_2723	COG0789	Transcriptional regulator
I33_2724	COG2315	Protein conserved in bacteria
I33_2727	COG3443	Belongs to the bacterial solute-binding protein 9 family
I33_2728	COG1595	DNA-templated transcription, initiation
I33_2729	COG0667	Aldo Keto reductase
I33_2730	COG3409	Peptidoglycan-binding domain 1 protein
I33_2731	COG5566	PFAM Mor transcription activator
I33_2732	COG0596	Alpha beta hydrolase
I33_2733	COG4991	sh3 domain protein
I33_2734	COG4991	sh3 domain protein
I33_2735	COG0346	lactoylglutathione lyase activity
I33_2737	COG5577	PFAM Coat F domain
I33_2738	COG1063	alcohol dehydrogenase
I33_2740	COG5577	PFAM Coat F domain
I33_2741	COG0789	Transcriptional regulator
I33_2742	COG1064	alcohol dehydrogenase
I33_2743	COG0693	protein deglycase activity
I33_2744	COG1621	beta-fructofuranosidase activity
I33_2745	COG3716	PTS system mannose fructose sorbose family IID component
I33_2746	COG3715	PTS system
I33_2747	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_2748	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_2749	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I33_2749	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I33_2750	COG1113	amino acid transport
I33_2751	COG1280	lysine exporter protein (LysE YggA)
I33_2752	COG1378	Sugar-specific transcriptional regulator TrmB
I33_2753	COG1595	DNA-templated transcription, initiation
I33_2755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I33_2755	COG2755	lipolytic protein G-D-S-L family
I33_2757	COG2124	cytochrome p450
I33_2757	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I33_2758	COG1309	transcriptional regulator
I33_2759	COG2226	methyltransferase
I33_2762	COG2116	formate transmembrane transporter activity
I33_2763	COG5609	conserved protein (DUF2294)
I33_2764	COG3383	formate dehydrogenase (NAD+) activity
I33_2765	COG2427	Protein of unknown function (DUF1641)
I33_2767	COG0626	cystathionine gamma-synthase activity
I33_2768	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I33_2769	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I33_2770	COG2226	methyltransferase
I33_2773	COG0768	penicillin binding
I33_2774	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I33_2775	COG0572	uridine kinase
I33_2779	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I33_2780	COG3906	Belongs to the UPF0473 family
I33_2781	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I33_2782	COG4472	Bacterial protein of unknown function (DUF965)
I33_2783	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I33_2784	COG0628	permease
I33_2786	COG1126	abc transporter atp-binding protein
I33_2787	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_2788	COG0765	amino acid transport
I33_2789	COG0765	amino acid transport
I33_2792	COG3881	PFAM PRC-barrel domain
I33_2793	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I33_2794	COG0457	Tetratricopeptide repeat
I33_2795	COG0482	sulfurtransferase activity
I33_2796	COG1104	cysteine desulfurase activity
I33_2797	COG1959	2 iron, 2 sulfur cluster binding
I33_2798	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I33_2799	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I33_2801	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I33_2802	COG0124	histidyl-tRNA synthetase
I33_2804	COG3103	Sh3 type 3 domain protein
I33_2804	COG4991	sh3 domain protein
I33_2804	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_2805	COG1490	D-aminoacyl-tRNA deacylase activity
I33_2806	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I33_2807	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I33_2808	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I33_2808	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I33_2809	COG5416	Lipopolysaccharide assembly protein A domain
I33_2810	COG0490	domain, Protein
I33_2811	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I33_2811	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I33_2813	COG2244	polysaccharide biosynthetic process
I33_2814	COG2323	membrane
I33_2816	COG1862	Preprotein translocase
I33_2817	COG0343	queuine tRNA-ribosyltransferase activity
I33_2818	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I33_2820	COG2255	four-way junction helicase activity
I33_2821	COG0632	four-way junction helicase activity
I33_2823	COG2814	Major facilitator Superfamily
I33_2824	COG0673	inositol 2-dehydrogenase activity
I33_2825	COG2112	serine threonine protein kinase
I33_2829	COG1115	amino acid carrier protein
I33_2830	COG0217	transcriptional regulatory protein
I33_2832	COG1388	LysM domain
I33_2833	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I33_2834	COG0157	Belongs to the NadC ModD family
I33_2835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I33_2836	COG1104	cysteine desulfurase activity
I33_2837	COG1827	regulation of RNA biosynthetic process
I33_2838	COG0077	Prephenate dehydratase
I33_2839	COG4492	Belongs to the UPF0735 family
I33_2840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I33_2841	COG3290	protein histidine kinase activity
I33_2843	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I33_2844	COG2868	ribosomal protein
I33_2845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I33_2846	COG1994	Peptidase M50
I33_2847	COG0739	heme binding
I33_2848	COG2894	cell division
I33_2849	COG0850	regulation of cytokinetic process
I33_2850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I33_2851	COG1792	Involved in formation and maintenance of cell shape
I33_2852	COG1077	Cell shape determining protein MreB Mrl
I33_2853	COG2003	Belongs to the UPF0758 family
I33_2854	COG0424	maF-like protein
I33_2856	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I33_2857	COG0285	dihydrofolate synthase activity
I33_2858	COG0525	valine-tRNA ligase activity
I33_2860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_2861	COG1388	LysM domain
I33_2862	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I33_2863	COG0113	porphobilinogen synthase activity
I33_2864	COG1587	Uroporphyrinogen-III synthase
I33_2865	COG0181	hydroxymethylbilane synthase activity
I33_2866	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I33_2867	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I33_2869	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I33_2870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I33_2871	COG0470	DNA polymerase III
I33_2871	COG1067	ATP-dependent peptidase activity
I33_2872	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I33_2873	COG0544	peptidyl-prolyl cis-trans isomerase activity
I33_2874	COG1477	protein flavinylation
I33_2874	COG0457	Tetratricopeptide repeat
I33_2876	COG0066	3-isopropylmalate dehydratase activity
I33_2877	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I33_2878	COG0473	3-isopropylmalate dehydrogenase activity
I33_2879	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I33_2880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I33_2881	COG0440	acetolactate synthase activity
I33_2882	COG0028	Belongs to the TPP enzyme family
I33_2884	COG0454	-acetyltransferase
I33_2886	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I33_2888	COG0622	Phosphoesterase
I33_2889	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I33_2890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I33_2891	COG5401	PFAM Sporulation and spore germination
I33_2892	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I33_2893	COG1846	Transcriptional regulator
I33_2895	COG2197	response regulator
I33_2896	COG0824	Thioesterase
I33_2897	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I33_2898	COG1053	succinate dehydrogenase
I33_2899	COG2009	succinate dehydrogenase
I33_2900	COG1719	4-vinyl reductase, 4VR
I33_2901	COG0527	aspartate kinase activity
I33_2902	COG0322	excinuclease ABC activity
I33_2903	COG3118	belongs to the thioredoxin family
I33_2906	COG3534	alpha-L-arabinofuranosidase
I33_2907	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I33_2908	COG2086	electron transfer activity
I33_2909	COG1024	Enoyl-CoA hydratase
I33_2910	COG1309	transcriptional regulator
I33_2911	COG0318	PFAM AMP-dependent synthetase and ligase
I33_2912	COG3766	membrane
I33_2913	COG1193	negative regulation of DNA recombination
I33_2914	COG1796	DNA polymerase
I33_2914	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I33_2915	COG1286	toxin biosynthetic process
I33_2916	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I33_2917	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I33_2918	COG0072	phenylalanine-tRNA ligase activity
I33_2918	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_2919	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I33_2921	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I33_2923	COG3835	regulator
I33_2924	COG0277	FAD linked oxidase domain protein
I33_2925	COG0247	lactate metabolic process
I33_2926	COG0346	lactoylglutathione lyase activity
I33_2927	COG1966	Carbon starvation protein
I33_2928	COG3534	alpha-L-arabinofuranosidase
I33_2929	COG0395	ABC-type sugar transport system, permease component
I33_2930	COG1175	transmembrane transport
I33_2931	COG1653	transport
I33_2932	COG0371	Dehydrogenase
I33_2933	COG0647	UMP catabolic process
I33_2934	COG0235	Class ii aldolase
I33_2935	COG1069	ribulokinase activity
I33_2936	COG2160	L-arabinose isomerase activity
I33_2937	COG3507	Belongs to the glycosyl hydrolase 43 family
I33_2938	COG1363	Peptidase, m42
I33_2940	COG3326	Membrane
I33_2941	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I33_2942	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I33_2943	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I33_2945	COG1346	cytolysis
I33_2946	COG1380	Effector of murein hydrolase LrgA
I33_2947	COG3279	Response regulator of the LytR AlgR family
I33_2948	COG3275	phosphorelay sensor kinase activity
I33_2950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I33_2953	COG0398	Pfam SNARE associated Golgi protein
I33_2954	COG1484	DNA-dependent DNA replication
I33_2955	COG3611	Membrane attachment protein
I33_2956	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I33_2958	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I33_2959	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I33_2960	COG1733	regulation of RNA biosynthetic process
I33_2961	COG2814	Major facilitator Superfamily
I33_2962	COG0656	L-ascorbic acid biosynthetic process
I33_2963	COG0237	dephospho-CoA kinase activity
I33_2964	COG1971	Probably functions as a manganese efflux pump
I33_2965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I33_2966	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I33_2966	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I33_2967	COG5002	protein histidine kinase activity
I33_2968	COG0745	RESPONSE REGULATOR receiver
I33_2970	COG0039	L-malate dehydrogenase activity
I33_2971	COG0538	isocitrate dehydrogenase activity
I33_2972	COG0372	Belongs to the citrate synthase family
I33_2973	COG2707	UPF0756 membrane protein
I33_2974	COG0628	permease
I33_2975	COG3030	protein affecting phage T7 exclusion by the F plasmid
I33_2976	COG0469	pyruvate kinase activity
I33_2977	COG0205	6-phosphofructokinase activity
I33_2979	COG0825	malonyl-CoA metabolic process
I33_2980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I33_2981	COG0281	malic enzyme
I33_2982	COG0587	DNA-directed DNA polymerase activity
I33_2986	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I33_2989	COG4109	DRTGG domain
I33_2990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I33_2991	COG1028	Short-chain dehydrogenase reductase Sdr
I33_2994	COG0165	Argininosuccinate lyase
I33_2995	COG0137	argininosuccinate synthase activity
I33_2996	COG0521	Mo-molybdopterin cofactor biosynthetic process
I33_2997	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I33_2999	COG0827	DNA restriction-modification system
I33_3000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I33_3001	COG3874	Sporulation protein YtfJ
I33_3003	COG1714	RDD family
I33_3004	COG0616	signal peptide processing
I33_3006	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I33_3007	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I33_3008	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I33_3010	COG0301	tRNA thio-modification
I33_3011	COG1104	cysteine desulfurase activity
I33_3012	COG1114	Component of the transport system for branched-chain amino acids
I33_3013	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I33_3014	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I33_3015	COG1309	transcriptional regulator
I33_3016	COG1956	GAF domain-containing protein
I33_3017	COG2203	Gaf domain
I33_3017	COG2199	diguanylate cyclase activity
I33_3019	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I33_3021	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I33_3022	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I33_3023	COG0454	-acetyltransferase
I33_3024	COG0517	IMP dehydrogenase activity
I33_3025	COG0123	including yeast histone deacetylase and acetoin utilization protein
I33_3026	COG1360	Flagellar Motor Protein
I33_3027	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I33_3028	COG1609	Transcriptional regulator
I33_3029	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I33_3029	COG1605	Chorismate mutase
I33_3030	COG3118	belongs to the thioredoxin family
I33_3031	COG4980	gas vesicle protein
I33_3032	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I33_3033	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I33_3036	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_3037	COG4848	Belongs to the UPF0354 family
I33_3038	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_3041	COG1363	Peptidase, m42
I33_3043	COG5584	Small secreted protein
I33_3044	COG0281	malic enzyme
I33_3045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_3046	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I33_3048	COG0510	thiamine kinase activity
I33_3049	COG1523	belongs to the glycosyl hydrolase 13 family
I33_3050	COG1597	lipid kinase activity
I33_3052	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I33_3053	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I33_3054	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I33_3055	COG2252	PERMEase
I33_3056	COG4473	ABC transporter
I33_3057	COG1131	(ABC) transporter
I33_3058	COG1349	DNA-binding transcription factor activity
I33_3059	COG1187	pseudouridine synthase activity
I33_3060	COG2244	polysaccharide biosynthetic process
I33_3061	COG2081	HI0933 family
I33_3062	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I33_3064	COG5578	integral membrane protein
I33_3065	COG0673	inositol 2-dehydrogenase activity
I33_3066	COG1653	transport
I33_3067	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I33_3068	COG4209	transmembrane transport
I33_3069	COG2207	Transcriptional regulator
I33_3070	COG1653	transport
I33_3071	COG0395	ABC-type sugar transport system, permease component
I33_3072	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I33_3073	COG2124	cytochrome p450
I33_3074	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I33_3076	COG0156	8-amino-7-oxononanoate synthase activity
I33_3077	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I33_3079	COG1073	alpha beta
I33_3084	COG1486	melibiose metabolic process
I33_3085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I33_3086	COG0495	leucyl-tRNA aminoacylation
I33_3089	COG2202	Pas domain
I33_3089	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_3090	COG2814	Major facilitator Superfamily
I33_3092	COG2433	Pfam Transposase IS66
I33_3093	COG0577	efflux transmembrane transporter activity
I33_3094	COG1136	(ABC) transporter
I33_3095	COG2205	protein histidine kinase activity
I33_3096	COG0745	RESPONSE REGULATOR receiver
I33_3097	COG0577	efflux transmembrane transporter activity
I33_3098	COG1136	(ABC) transporter
I33_3101	COG1131	(ABC) transporter
I33_3102	COG1725	Transcriptional regulator
I33_3105	COG1242	4 iron, 4 sulfur cluster binding
I33_3106	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I33_3108	COG2267	carboxylic ester hydrolase activity
I33_3109	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I33_3110	COG1113	amino acid transport
I33_3111	COG0367	asparagine synthase
I33_3112	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I33_3113	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I33_3115	COG1506	peptidase
I33_3116	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I33_3117	COG1116	anion transmembrane transporter activity
I33_3118	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I33_3119	COG0494	nUDIX hydrolase
I33_3120	COG4824	toxin secretion phage lysis holin
I33_3122	COG0783	Belongs to the Dps family
I33_3125	COG1854	S-ribosylhomocysteine lyase activity
I33_3126	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I33_3127	COG0288	reversible hydration of carbon dioxide
I33_3128	COG0254	rRNA binding
I33_3129	COG1271	oxidase subunit
I33_3130	COG1294	oxidase, subunit
I33_3132	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I33_3133	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I33_3133	COG1321	iron dependent repressor
I33_3134	COG1121	(ABC) transporter
I33_3135	COG0803	Belongs to the bacterial solute-binding protein 9 family
I33_3137	COG4948	Mandelate Racemase Muconate Lactonizing
I33_3138	COG0318	PFAM AMP-dependent synthetase and ligase
I33_3139	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I33_3140	COG0596	Alpha beta hydrolase
I33_3141	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I33_3142	COG1169	isochorismate synthase
I33_3143	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I33_3144	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I33_3146	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I33_3147	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I33_3148	COG0438	transferase activity, transferring glycosyl groups
I33_3150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_3151	COG0438	transferase activity, transferring glycosyl groups
I33_3152	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_3153	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I33_3154	COG0058	SHG alpha-glucan phosphorylase activity
I33_3155	COG0297	glycogen (starch) synthase activity
I33_3156	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I33_3157	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I33_3158	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I33_3183	COG3859	Proton-coupled thiamine transporter YuaJ
I33_3184	COG1247	-acetyltransferase
I33_3185	COG2268	Band 7 protein
I33_3186	COG1585	Membrane protein implicated in regulation of membrane protease activity
I33_3187	COG2318	DinB family
I33_3189	COG1454	alcohol dehydrogenase
I33_3191	COG1510	regulation of RNA biosynthetic process
I33_3193	COG0569	domain protein
I33_3194	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I33_3195	COG4682	membrane
I33_3196	COG1705	Flagellar rod assembly protein muramidase FlgJ
I33_3197	COG0477	Major facilitator Superfamily
I33_3198	COG5553	Cysteine dioxygenase type I
I33_3201	COG1968	undecaprenyl-diphosphatase activity
I33_3202	COG0628	permease
I33_3203	COG0673	inositol 2-dehydrogenase activity
I33_3204	COG4806	L-rhamnose isomerase
I33_3207	COG1070	Carbohydrate kinase
I33_3208	COG1349	DNA-binding transcription factor activity
I33_3209	COG1028	Short-chain dehydrogenase reductase Sdr
I33_3209	COG3347	Dehydrogenase
I33_3210	COG0840	transmembrane signaling receptor activity
I33_3211	COG0840	transmembrane signaling receptor activity
I33_3212	COG0840	transmembrane signaling receptor activity
I33_3213	COG0840	transmembrane signaling receptor activity
I33_3217	COG0432	Pfam Uncharacterised protein family UPF0047
I33_3218	COG0366	Alpha amylase catalytic
I33_3219	COG1253	flavin adenine dinucleotide binding
I33_3220	COG2738	Putative neutral zinc metallopeptidase
I33_3223	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I33_3226	COG0166	Belongs to the GPI family
I33_3227	COG1979	alcohol dehydrogenase
I33_3228	COG1979	alcohol dehydrogenase
I33_3229	COG2155	Conserved Protein
I33_3230	COG1098	S1 RNA binding domain
I33_3231	COG0436	Aminotransferase
I33_3232	COG1522	sequence-specific DNA binding
I33_3233	COG2267	carboxylic ester hydrolase activity
I33_3235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I33_3236	COG2205	protein histidine kinase activity
I33_3238	COG5018	Exonuclease
I33_3240	COG2814	Major facilitator Superfamily
I33_3241	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I33_3242	COG3011	Protein conserved in bacteria
I33_3244	COG3290	protein histidine kinase activity
I33_3245	COG4565	transcriptional regulatory protein
I33_3250	COG3493	citrate carrier protein
I33_3252	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I33_3252	COG2111	Na H antiporter
I33_3253	COG2111	Na H antiporter
I33_3254	COG1006	Multisubunit Na H antiporter MnhC subunit
I33_3255	COG0651	ATP synthesis coupled electron transport
I33_3256	COG1863	multisubunit Na H antiporter MnhE subunit
I33_3257	COG2212	antiporter activity
I33_3258	COG1320	monovalent cation:proton antiporter activity
I33_3259	COG2050	protein possibly involved in aromatic compounds catabolism
I33_3260	COG2197	response regulator
I33_3261	COG4585	Histidine kinase
I33_3263	COG0142	geranyltranstransferase activity
I33_3266	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I33_3267	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I33_3268	COG1335	isochorismatase
I33_3269	COG5506	Protein of unknown function (DUF1694)
I33_3272	COG0628	permease
I33_3275	COG1418	mRNA catabolic process
I33_3276	COG1028	Short-chain dehydrogenase reductase Sdr
I33_3278	COG1511	domain protein
I33_3279	COG0433	COG0433 Predicted ATPase
I33_3279	COG1674	ftsk spoiiie
I33_3280	COG4499	WXG100 protein secretion system (Wss), protein YukC
I33_3281	COG5417	Belongs to the EsaB family
I33_3282	COG4842	Belongs to the WXG100 family
I33_3283	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I33_3283	COG2508	Transcriptional regulator
I33_3284	COG0686	Belongs to the AlaDH PNT family
I33_3285	COG5634	Uncharacterized conserved protein (DUF2278)
I33_3286	COG3251	PFAM MbtH domain protein
I33_3287	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_3288	COG1535	isochorismatase
I33_3288	COG3433	isochorismatase activity
I33_3289	COG1021	2,3-dihydroxybenzoate-AMP ligase
I33_3290	COG1169	isochorismate synthase
I33_3291	COG1028	Short-chain dehydrogenase reductase Sdr
I33_3292	COG2819	hydrolase of the alpha beta superfamily
I33_3293	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I33_3294	COG1268	BioY protein
I33_3295	COG2056	Na+-H+ antiporter family
I33_3296	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I33_3297	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I33_3298	COG3584	3D domain protein
I33_3301	COG1252	NADH dehydrogenase
I33_3303	COG0492	ferredoxin-NADP+ reductase activity
I33_3306	COG0516	GMP reductase activity
I33_3309	COG1131	(ABC) transporter
I33_3313	COG2808	Putative FMN-binding domain
I33_3314	COG0456	acetyltransferase
I33_3315	COG0316	Belongs to the HesB IscA family
I33_3316	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I33_3317	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I33_3318	COG4844	belongs to the
I33_3319	COG1252	NADH dehydrogenase
I33_3320	COG4837	Protein of unknown function (DUF1462)
I33_3321	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I33_3322	COG0823	Involved in the tonB-independent uptake of proteins
I33_3322	COG4946	Tricorn protease homolog
I33_3322	COG1506	peptidase
I33_3323	COG0083	homoserine kinase activity
I33_3324	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I33_3325	COG0460	homoserine dehydrogenase
I33_3326	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_3328	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I33_3329	COG0647	UMP catabolic process
I33_3330	COG2445	Protein of unknown function DUF86
I33_3331	COG4470	Protein conserved in bacteria
I33_3333	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I33_3334	COG0739	heme binding
I33_3336	COG3377	Domain of unknown function (DUF1805)
I33_3337	COG0737	Belongs to the 5'-nucleotidase family
I33_3338	COG0730	response to heat
I33_3339	COG1801	Protein of unknown function DUF72
I33_3341	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I33_3342	COG2508	Transcriptional regulator
I33_3343	COG2233	PERMEase
I33_3344	COG2233	PERMEase
I33_3345	COG3195	allantoin biosynthetic process
I33_3345	COG3648	Uricase
I33_3346	COG2351	hydroxyisourate hydrolase activity
I33_3347	COG0457	Tetratricopeptide repeat
I33_3348	COG0457	Tetratricopeptide repeat
I33_3350	COG2080	2 iron, 2 sulfur cluster binding
I33_3351	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I33_3352	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I33_3353	COG2068	MobA-Related Protein
I33_3354	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I33_3355	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I33_3356	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I33_3358	COG2356	endonuclease I
I33_3359	COG3842	ATPase activity
I33_3360	COG2188	Transcriptional regulator
I33_3361	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_3362	COG0395	ABC-type sugar transport system, permease component
I33_3363	COG1175	transmembrane transport
I33_3364	COG1653	transport
I33_3365	COG2222	sugar isomerase
I33_3366	COG0322	excinuclease ABC activity
I33_3367	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I33_3370	COG0346	lactoylglutathione lyase activity
I33_3371	COG0719	Fe-S assembly protein
I33_3372	COG0822	iron-sulfur transferase activity
I33_3373	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I33_3374	COG0719	Fe-S assembly protein
I33_3375	COG0396	ATPase activity
I33_3379	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I33_3380	COG1464	Belongs to the NlpA lipoprotein family
I33_3381	COG2011	ABC-type metal ion transport system permease component
I33_3382	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I33_3385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_3386	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I33_3388	COG0509	glycine decarboxylation via glycine cleavage system
I33_3389	COG1393	Belongs to the ArsC family
I33_3390	COG1960	acyl-CoA dehydrogenase activity
I33_3391	COG0183	Belongs to the thiolase family
I33_3392	COG1250	3-hydroxyacyl-CoA dehydrogenase
I33_3392	COG1024	Enoyl-CoA hydratase
I33_3393	COG0506	proline dehydrogenase activity
I33_3395	COG5577	PFAM Coat F domain
I33_3396	COG1846	Transcriptional regulator
I33_3397	COG0477	Major facilitator Superfamily
I33_3398	COG1942	4-Oxalocrotonate Tautomerase
I33_3399	COG1028	Short-chain dehydrogenase reductase Sdr
I33_3400	COG0583	DNA-binding transcription factor activity
I33_3402	COG1120	ATPase activity
I33_3405	COG1028	Short-chain dehydrogenase reductase Sdr
I33_3406	COG0783	Belongs to the Dps family
I33_3407	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I33_3409	COG0745	RESPONSE REGULATOR receiver
I33_3410	COG2770	Histidine kinase
I33_3410	COG2205	protein histidine kinase activity
I33_3412	COG1309	transcriptional regulator
I33_3413	COG0114	fumarate hydratase activity
I33_3415	COG0697	spore germination
I33_3416	COG0814	amino acid
I33_3418	COG2197	response regulator
I33_3419	COG4585	Histidine kinase
I33_3420	COG4758	membrane
I33_3421	COG3595	metallopeptidase activity
I33_3422	COG1842	Phage shock protein A
I33_3423	COG4758	membrane
I33_3424	COG2814	Major facilitator Superfamily
I33_3426	COG2096	Adenosyltransferase
I33_3427	COG1120	ATPase activity
I33_3428	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_3429	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_3431	COG1028	Short-chain dehydrogenase reductase Sdr
I33_3432	COG3386	PFAM SMP-30 Gluconolaconase
I33_3433	COG2205	protein histidine kinase activity
I33_3434	COG0745	RESPONSE REGULATOR receiver
I33_3437	COG1191	sigma factor activity
I33_3439	COG2140	Oxalate decarboxylase
I33_3441	COG0577	efflux transmembrane transporter activity
I33_3442	COG1136	(ABC) transporter
I33_3443	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I33_3445	COG1120	ATPase activity
I33_3446	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_3447	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_3448	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_3451	COG0531	amino acid
I33_3453	COG1988	membrane-bound metal-dependent
I33_3454	COG1368	sulfuric ester hydrolase activity
I33_3455	COG1910	domain protein
I33_3456	COG0725	ABC transporter, periplasmic molybdate-binding protein
I33_3457	COG4149	molybdate abc transporter
I33_3458	COG0656	L-ascorbic acid biosynthetic process
I33_3460	COG0025	NhaP-type Na H and K H
I33_3461	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I33_3462	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I33_3463	COG3973	AAA domain
I33_3465	COG2860	membrane
I33_3467	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I33_3468	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I33_3469	COG2217	Heavy metal translocating P-type atpase
I33_3470	COG2217	Heavy metal translocating P-type atpase
I33_3471	COG2608	mercury ion transmembrane transporter activity
I33_3472	COG1937	Protein conserved in bacteria
I33_3473	COG0673	inositol 2-dehydrogenase activity
I33_3474	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I33_3475	COG1289	transmembrane transporter activity
I33_3477	COG2076	Multidrug Resistance protein
I33_3478	COG1309	transcriptional regulator
I33_3479	COG1028	Short-chain dehydrogenase reductase Sdr
I33_3482	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I33_3483	COG0557	exoribonuclease II activity
I33_3484	COG1647	Serine aminopeptidase, S33
I33_3485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I33_3486	COG0596	Alpha beta hydrolase
I33_3487	COG1476	TRANSCRIPTIONal
I33_3488	COG1396	sequence-specific DNA binding
I33_3489	COG1396	sequence-specific DNA binding
I33_3490	COG1733	regulation of RNA biosynthetic process
I33_3491	COG0840	transmembrane signaling receptor activity
I33_3492	COG1174	glycine betaine transport
I33_3493	COG1732	Glycine betaine
I33_3494	COG1174	glycine betaine transport
I33_3495	COG0517	IMP dehydrogenase activity
I33_3495	COG1125	glycine betaine transport
I33_3496	COG1510	regulation of RNA biosynthetic process
I33_3497	COG1174	glycine betaine transport
I33_3498	COG1732	Glycine betaine
I33_3499	COG1174	glycine betaine transport
I33_3500	COG0517	IMP dehydrogenase activity
I33_3500	COG1125	glycine betaine transport
I33_3501	COG1510	regulation of RNA biosynthetic process
I33_3502	COG2095	MarC family integral membrane protein
I33_3504	COG3064	Membrane
I33_3505	COG4640	response to antibiotic
I33_3506	COG0456	acetyltransferase
I33_3507	COG0148	phosphopyruvate hydratase activity
I33_3508	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I33_3509	COG0149	triose-phosphate isomerase activity
I33_3510	COG0126	phosphoglycerate kinase activity
I33_3512	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I33_3513	COG2390	Transcriptional regulator
I33_3514	COG2814	Major facilitator Superfamily
I33_3515	COG1609	Transcriptional regulator
I33_3516	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_3517	COG0583	DNA-binding transcription factor activity
I33_3518	COG0697	spore germination
I33_3519	COG1113	amino acid transport
I33_3520	COG3858	chitin binding
I33_3521	COG1556	Lactate utilization protein
I33_3522	COG1139	Iron-sulfur cluster binding protein
I33_3523	COG0247	lactate metabolic process
I33_3524	COG2197	response regulator
I33_3525	COG4585	Histidine kinase
I33_3526	COG0842	Transport permease protein
I33_3527	COG1131	(ABC) transporter
I33_3529	COG0596	Alpha beta hydrolase
I33_3530	COG2208	phosphoserine phosphatase activity
I33_3531	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I33_3532	COG1874	Beta-galactosidase
I33_3533	COG3833	ABC-type maltose transport systems, permease component
I33_3534	COG1175	transmembrane transport
I33_3535	COG2182	Extracellular solute-binding protein
I33_3536	COG1609	Transcriptional regulator
I33_3537	COG2186	Transcriptional regulator
I33_3538	COG1620	l-lactate permease
I33_3539	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I33_3542	COG5039	Polysaccharide pyruvyl transferase
I33_3543	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I33_3544	COG0110	maltose O-acetyltransferase activity
I33_3545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I33_3546	COG2244	polysaccharide biosynthetic process
I33_3547	COG1216	Glycosyl transferase, family 2
I33_3548	COG5039	Polysaccharide pyruvyl transferase
I33_3549	COG1216	Glycosyl transferase, family 2
I33_3551	COG0438	transferase activity, transferring glycosyl groups
I33_3552	COG1215	transferase activity, transferring glycosyl groups
I33_3553	COG0438	transferase activity, transferring glycosyl groups
I33_3554	COG1086	Polysaccharide biosynthesis protein
I33_3555	COG0489	protein tyrosine kinase activity
I33_3556	COG3944	biosynthesis protein
I33_3557	COG1396	sequence-specific DNA binding
I33_3558	COG2272	Belongs to the type-B carboxylesterase lipase family
I33_3560	COG3479	Phenolic acid decarboxylase
I33_3562	COG1794	racemase activity, acting on amino acids and derivatives
I33_3563	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I33_3564	COG1621	beta-fructofuranosidase activity
I33_3565	COG1621	beta-fructofuranosidase activity
I33_3566	COG0531	amino acid
I33_3567	COG1309	transcriptional regulator
I33_3568	COG2076	Multidrug Resistance protein
I33_3569	COG2076	Multidrug Resistance protein
I33_3573	COG0740	serine-type endopeptidase activity
I33_3574	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I33_3575	COG0366	Alpha amylase catalytic
I33_3576	COG1554	hydrolase, family 65, central catalytic
I33_3577	COG5521	maltodextrose utilization protein MalA
I33_3578	COG3833	ABC-type maltose transport systems, permease component
I33_3579	COG1175	transmembrane transport
I33_3580	COG2182	Extracellular solute-binding protein
I33_3581	COG0366	Alpha amylase catalytic
I33_3582	COG1609	Transcriptional regulator
I33_3583	COG1611	Belongs to the LOG family
I33_3584	COG1694	Mazg nucleotide pyrophosphohydrolase
I33_3585	COG0659	secondary active sulfate transmembrane transporter activity
I33_3586	COG0288	reversible hydration of carbon dioxide
I33_3587	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I33_3588	COG0577	efflux transmembrane transporter activity
I33_3589	COG1136	(ABC) transporter
I33_3590	COG5002	protein histidine kinase activity
I33_3591	COG0745	RESPONSE REGULATOR receiver
I33_3593	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I33_3594	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_3595	COG1481	regulation of sporulation
I33_3596	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I33_3597	COG1660	Displays ATPase and GTPase activities
I33_3598	COG1051	belongs to the nudix hydrolase family
I33_3599	COG0492	ferredoxin-NADP+ reductase activity
I33_3600	COG0791	NLP P60 protein
I33_3600	COG3883	PFAM NLP P60 protein
I33_3608	COG0457	Tetratricopeptide repeat
I33_3609	COG1132	(ABC) transporter
I33_3617	COG0140	phosphoribosyl-ATP diphosphatase activity
I33_3617	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I33_3618	COG0107	imidazoleglycerol-phosphate synthase activity
I33_3619	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I33_3620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I33_3621	COG0131	Imidazoleglycerol-phosphate dehydratase
I33_3622	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I33_3623	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I33_3624	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I33_3625	COG4990	cell redox homeostasis
I33_3626	COG5297	Belongs to the glycosyl hydrolase family 6
I33_3627	COG0110	maltose O-acetyltransferase activity
I33_3628	COG0546	phosphoglycolate phosphatase activity
I33_3629	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I33_3630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I33_3631	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I33_3632	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I33_3633	COG0363	glucosamine-6-phosphate deaminase activity
I33_3635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I33_3636	COG1846	Transcriptional regulator
I33_3637	COG1950	PFAM Membrane protein of
I33_3638	COG1983	PspC domain protein
I33_3639	COG3595	metallopeptidase activity
I33_3642	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I33_3643	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I33_3644	COG0556	nucleotide-excision repair
I33_3645	COG4897	Protein conserved in bacteria
I33_3647	COG0574	Belongs to the PEP-utilizing enzyme family
I33_3647	COG3848	Pyruvate phosphate dikinase
I33_3648	COG1309	transcriptional regulator
I33_3649	COG2814	Major facilitator Superfamily
I33_3650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I33_3652	COG0793	Belongs to the peptidase S41A family
I33_3652	COG3409	Peptidoglycan-binding domain 1 protein
I33_3653	COG2177	Part of the ABC transporter FtsEX involved in
I33_3654	COG2884	Cell division ATP-binding protein ftsE
I33_3655	COG2010	Cytochrome c
I33_3656	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_3657	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I33_3658	COG0653	protein targeting
I33_3659	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I33_3662	COG1516	flagellar protein fliS
I33_3663	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I33_3664	COG1334	flagellar protein FlaG
I33_3665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I33_3666	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I33_3667	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I33_3669	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I33_3670	COG1256	bacterial-type flagellum assembly
I33_3670	COG4786	Flagellar basal body rod
I33_3671	COG3418	PFAM FlgN family protein
I33_3672	COG2747	anti-sigma28 factor FlgM
I33_3674	COG1040	competence protein
I33_3676	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I33_3677	COG1307	EDD domain protein, DegV family
I33_3678	COG2197	response regulator
I33_3679	COG4585	Histidine kinase
I33_3680	COG1739	Uncharacterized protein family UPF0029
I33_3681	COG1316	TRANSCRIPTIONal
I33_3682	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I33_3683	COG0438	transferase activity, transferring glycosyl groups
I33_3684	COG1215	transferase activity, transferring glycosyl groups
I33_3685	COG3206	protein involved in exopolysaccharide biosynthesis
I33_3686	COG3307	-O-antigen
I33_3687	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I33_3688	COG0297	glycogen (starch) synthase activity
I33_3688	COG0438	transferase activity, transferring glycosyl groups
I33_3689	COG2244	polysaccharide biosynthetic process
I33_3692	COG2247	cell wall binding repeat
I33_3692	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_3693	COG2385	sporulation resulting in formation of a cellular spore
I33_3693	COG2247	cell wall binding repeat
I33_3695	COG1316	TRANSCRIPTIONal
I33_3696	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I33_3697	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I33_3698	COG1134	teichoic acid transport
I33_3699	COG1682	transport, permease protein
I33_3701	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I33_3702	COG0438	transferase activity, transferring glycosyl groups
I33_3703	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I33_3704	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I33_3705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I33_3707	COG4193	domain, Protein
I33_3708	COG1482	cell wall glycoprotein biosynthetic process
I33_3710	COG0814	amino acid
I33_3712	COG2814	Major facilitator Superfamily
I33_3713	COG1316	TRANSCRIPTIONal
I33_3714	COG0561	phosphatase activity
I33_3715	COG0791	NLP P60 protein
I33_3717	COG2843	Capsule synthesis protein
I33_3719	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I33_3720	COG1609	Transcriptional regulator
I33_3721	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_3722	COG1869	D-ribose catabolic process
I33_3723	COG1129	ABC transporter
I33_3724	COG1172	Belongs to the binding-protein-dependent transport system permease family
I33_3725	COG1879	ABC-type sugar transport system periplasmic component
I33_3726	COG3103	Sh3 type 3 domain protein
I33_3728	COG2249	NAD(P)H dehydrogenase (quinone) activity
I33_3729	COG3527	Alpha-acetolactate decarboxylase
I33_3730	COG0028	Belongs to the TPP enzyme family
I33_3731	COG0583	DNA-binding transcription factor activity
I33_3732	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I33_3735	COG5337	Spore coat protein CotH
I33_3737	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I33_3739	COG0405	Gamma-glutamyltransferase
I33_3740	COG1522	sequence-specific DNA binding
I33_3741	COG2059	Chromate
I33_3742	COG2059	Chromate
I33_3743	COG1515	deoxyribonuclease V activity
I33_3749	COG5444	nuclease activity
I33_3753	COG3878	Protein conserved in bacteria
I33_3754	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I33_3755	COG4464	protein tyrosine phosphatase activity
I33_3756	COG0489	protein tyrosine kinase activity
I33_3757	COG3944	biosynthesis protein
I33_3759	COG4715	Zinc finger, swim domain protein
I33_3760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I33_3761	COG0561	phosphatase activity
I33_3762	COG1349	DNA-binding transcription factor activity
I33_3763	COG0629	single-stranded DNA binding
I33_3766	COG3764	Sortase (surface protein transpeptidase)
I33_3769	COG3279	Response regulator of the LytR AlgR family
I33_3770	COG0745	RESPONSE REGULATOR receiver
I33_3770	COG2972	Histidine kinase
I33_3771	COG1970	mechanosensitive ion channel activity
I33_3772	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I33_3773	COG0457	Tetratricopeptide repeat
I33_3774	COG4786	Flagellar basal body rod
I33_3775	COG4786	Flagellar basal body rod
I33_3776	COG1077	Cell shape determining protein MreB Mrl
I33_3777	COG1609	Transcriptional regulator
I33_3778	COG1846	Transcriptional regulator
I33_3779	COG2814	Major facilitator Superfamily
I33_3781	COG3420	alginic acid biosynthetic process
I33_3782	COG1953	Uracil, thiamine, allantoin
I33_3783	COG0477	Major facilitator Superfamily
I33_3784	COG1335	isochorismatase
I33_3786	COG0004	ammonium transporteR
I33_3787	COG0347	Belongs to the P(II) protein family
I33_3788	COG0671	phosphoesterase, PA-phosphatase related
I33_3790	COG0739	heme binding
I33_3791	COG1247	-acetyltransferase
I33_3795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I33_3796	COG0789	Transcriptional regulator
I33_3798	COG2910	NAD(P)H-binding
I33_3799	COG1959	2 iron, 2 sulfur cluster binding
I33_3800	COG0804	urea catabolic process
I33_3801	COG0832	Belongs to the urease beta subunit family
I33_3802	COG0831	urea catabolic process
I33_3806	COG3237	CsbD-like
I33_3807	COG1994	Peptidase M50
I33_3809	COG0457	Tetratricopeptide repeat
I33_3810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I33_3811	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I33_3813	COG2304	oxidoreductase activity
I33_3816	COG2304	oxidoreductase activity
I33_3818	COG2385	sporulation resulting in formation of a cellular spore
I33_3819	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I33_3821	COG4836	Membrane
I33_3823	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I33_3824	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I33_3825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I33_3826	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I33_3827	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I33_3828	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I33_3829	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I33_3830	COG0356	it plays a direct role in the translocation of protons across the membrane
I33_3832	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I33_3833	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I33_3834	COG4475	Protein of unknown function (DUF436)
I33_3835	COG0698	ribose 5-phosphate isomerase
I33_3837	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I33_3838	COG1971	Probably functions as a manganese efflux pump
I33_3839	COG0009	L-threonylcarbamoyladenylate synthase
I33_3840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I33_3844	COG2890	protein-(glutamine-N5) methyltransferase activity
I33_3845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I33_3846	COG0346	lactoylglutathione lyase activity
I33_3847	COG0789	Transcriptional regulator
I33_3848	COG0679	Auxin Efflux Carrier
I33_3849	COG0281	malic enzyme
I33_3850	COG1435	thymidine kinase activity
I33_3851	COG0254	rRNA binding
I33_3852	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I33_3854	COG1494	fructose-1,6-bisphosphatase
I33_3855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I33_3856	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I33_3857	COG0191	fructose-bisphosphate aldolase activity
I33_3858	COG2204	response regulator
I33_3859	COG4821	SIS domain
I33_3860	COG0504	CTP synthase activity
I33_3861	COG3343	RNA polymerase activity
I33_3862	COG1960	acyl-CoA dehydrogenase activity
I33_3863	COG0247	lactate metabolic process
I33_3863	COG2181	nitrate reductase activity
I33_3864	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I33_3865	COG4294	response to UV
I33_3867	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I33_3868	COG1132	(ABC) transporter
I33_3869	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I33_3871	COG2181	nitrate reductase activity
I33_3872	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I33_3873	COG1140	nitrate reductase beta subunit
I33_3874	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I33_3875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I33_3877	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I33_3878	COG2223	nitrite transmembrane transporter activity
I33_3879	COG0018	arginyl-trna synthetase
I33_3880	COG4506	Protein conserved in bacteria
I33_3882	COG0535	radical SAM domain protein
I33_3884	COG1131	(ABC) transporter
I33_3885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I33_3886	COG0612	Peptidase, M16
I33_3887	COG0612	Peptidase, M16
I33_3889	COG3391	amine dehydrogenase activity
I33_3890	COG3391	amine dehydrogenase activity
I33_3892	COG0457	Tetratricopeptide repeat
I33_3893	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I33_3894	COG0010	Belongs to the arginase family
I33_3895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I33_3896	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I33_3899	COG1994	Peptidase M50
I33_3900	COG1942	4-Oxalocrotonate Tautomerase
I33_3901	COG1846	Transcriptional regulator
I33_3902	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I33_3904	COG0477	Major facilitator Superfamily
I33_3905	COG1959	2 iron, 2 sulfur cluster binding
I33_3906	COG3465	dGTPase activity
I33_3907	COG1078	dGTPase activity
I33_3908	COG4844	belongs to the
I33_3910	COG0697	spore germination
I33_3912	COG0095	Lipoate-protein ligase
I33_3913	COG0583	DNA-binding transcription factor activity
I33_3914	COG0280	phosphate acetyltransferase
I33_3916	COG1028	Short-chain dehydrogenase reductase Sdr
I33_3917	COG0436	Aminotransferase
I33_3918	COG2814	Major facilitator Superfamily
I33_3919	COG0151	Belongs to the GarS family
I33_3920	COG1028	Short-chain dehydrogenase reductase Sdr
I33_3921	COG1917	Cupin 2, conserved barrel domain protein
I33_3922	COG0077	Prephenate dehydratase
I33_3924	COG2814	Major facilitator Superfamily
I33_3925	COG0833	amino acid
I33_3926	COG4187	Peptidase family M20/M25/M40
I33_3927	COG1012	belongs to the aldehyde dehydrogenase family
I33_3929	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I33_3934	COG1088	dTDP-glucose 4,6-dehydratase activity
I33_3935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I33_3937	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I33_3938	COG2089	acid synthase
I33_3939	COG0456	acetyltransferase
I33_3940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I33_3941	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I33_3942	COG0463	Glycosyl transferase, family 2
I33_3945	COG2363	Small membrane protein
I33_3946	COG2233	PERMEase
I33_3949	COG1012	belongs to the aldehyde dehydrogenase family
I33_3950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I33_3951	COG1216	Glycosyl transferase, family 2
I33_3952	COG0351	phosphomethylpyrimidine kinase
I33_3954	COG1621	beta-fructofuranosidase activity
I33_3955	COG1263	PTS System
I33_3955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_3956	COG2116	formate transmembrane transporter activity
I33_3960	COG1404	Belongs to the peptidase S8 family
I33_3961	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_3962	COG0778	Nitroreductase
I33_3963	COG0772	Belongs to the SEDS family
I33_3965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I33_3966	COG1845	cytochrome c oxidase, subunit III
I33_3967	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I33_3968	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I33_3969	COG2261	transglycosylase associated protein
I33_3970	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I33_3971	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I33_3972	COG2246	polysaccharide biosynthetic process
I33_3973	COG1309	transcriptional regulator
I33_3975	COG3162	membrane
I33_3976	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_3977	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I33_3978	COG2837	iron assimilation
I33_3979	COG2822	iron ion transport
I33_3980	COG0672	)-iron permease
I33_3981	COG0352	thiamine-phosphate diphosphorylase activity
I33_3982	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I33_3983	COG0583	DNA-binding transcription factor activity
I33_3984	COG1380	Effector of murein hydrolase LrgA
I33_3985	COG1346	cytolysis
I33_3986	COG2814	Major facilitator Superfamily
I33_3987	COG4895	conserved protein (DUF2196)
I33_3988	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I33_3989	COG0346	lactoylglutathione lyase activity
I33_3992	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_3994	COG1404	Belongs to the peptidase S8 family
I33_3995	COG1263	PTS System
I33_3995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_3996	COG3711	transcriptional antiterminator
I33_3997	COG1442	glycosyl transferase family 8
I33_3998	COG5522	Integral membrane protein (intg_mem_TP0381)
I33_3999	COG1846	Transcriptional regulator
I33_4000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I33_4001	COG2234	aminopeptidase activity
I33_4002	COG2357	RelA SpoT domain protein
I33_4003	COG1575	Belongs to the MenA family. Type 1 subfamily
I33_4006	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_4007	COG1696	Membrane protein involved in D-alanine export
I33_4008	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_4009	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I33_4010	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I33_4011	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I33_4012	COG1486	melibiose metabolic process
I33_4013	COG1447	Phosphotransferase system cellobiose-specific component IIA
I33_4014	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_4015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_4016	COG3711	transcriptional antiterminator
I33_4016	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_4018	COG2094	Belongs to the DNA glycosylase MPG family
I33_4019	COG0753	catalase activity
I33_4020	COG2814	Major facilitator Superfamily
I33_4021	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I33_4022	COG1131	(ABC) transporter
I33_4026	COG1595	DNA-templated transcription, initiation
I33_4027	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I33_4028	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I33_4030	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I33_4031	COG4988	ABC transporter
I33_4032	COG1294	oxidase, subunit
I33_4033	COG1271	oxidase subunit
I33_4034	COG3493	citrate carrier protein
I33_4035	COG0501	Belongs to the peptidase M48B family
I33_4037	COG0726	polysaccharide deacetylase
I33_4039	COG3842	ATPase activity
I33_4040	COG2508	Transcriptional regulator
I33_4041	COG1012	belongs to the aldehyde dehydrogenase family
I33_4042	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_4044	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I33_4045	COG1881	PFAM PEBP family protein
I33_4046	COG0583	DNA-binding transcription factor activity
I33_4049	COG4585	Histidine kinase
I33_4050	COG2197	response regulator
I33_4051	COG2195	Cleaves the N-terminal amino acid of tripeptides
I33_4054	COG4894	glucomannan catabolic process
I33_4055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I33_4056	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I33_4057	COG1028	Short-chain dehydrogenase reductase Sdr
I33_4058	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I33_4059	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I33_4060	COG2610	gluconate transmembrane transporter activity
I33_4061	COG0500	methyltransferase
I33_4063	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I33_4066	COG0753	catalase activity
I33_4066	COG0693	protein deglycase activity
I33_4068	COG2851	Citrate transporter
I33_4069	COG2273	Hydrolase Family 16
I33_4070	COG3711	transcriptional antiterminator
I33_4073	COG2270	Major facilitator Superfamily
I33_4074	COG0513	Belongs to the DEAD box helicase family
I33_4075	COG2755	lipolytic protein G-D-S-L family
I33_4075	COG3401	FG-GAP repeat protein
I33_4082	COG0697	spore germination
I33_4083	COG0589	response to stress
I33_4084	COG2723	6-phospho-beta-galactosidase activity
I33_4085	COG2190	(PTS) system
I33_4085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_4085	COG1263	PTS System
I33_4093	COG5444	nuclease activity
I33_4099	COG0494	nUDIX hydrolase
I33_4100	COG3507	Belongs to the glycosyl hydrolase 43 family
I33_4103	COG2986	histidine ammonia-lyase
I33_4104	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I33_4105	COG1228	amidohydrolase
I33_4106	COG0010	Belongs to the arginase family
I33_4107	COG0833	amino acid
I33_4108	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I33_4109	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I33_4110	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I33_4111	COG2390	Transcriptional regulator
I33_4113	COG3192	ethanolamine utilization protein
I33_4114	COG2079	MmgE PrpD family protein
I33_4116	COG1126	abc transporter atp-binding protein
I33_4117	COG0765	amino acid transport
I33_4118	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_4122	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I33_4123	COG0561	phosphatase activity
I33_4130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_4131	COG5294	Protein conserved in bacteria
I33_4132	COG0577	efflux transmembrane transporter activity
I33_4133	COG1136	(ABC) transporter
I33_4134	COG2205	protein histidine kinase activity
I33_4135	COG0745	RESPONSE REGULATOR receiver
I33_4136	COG0191	fructose-bisphosphate aldolase activity
I33_4137	COG1082	Xylose isomerase domain protein TIM barrel
I33_4138	COG1082	Xylose isomerase domain protein TIM barrel
I33_4139	COG0673	inositol 2-dehydrogenase activity
I33_4140	COG2814	Major facilitator Superfamily
I33_4141	COG1082	Xylose isomerase domain protein TIM barrel
I33_4142	COG3962	Belongs to the TPP enzyme family
I33_4143	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_4145	COG1012	belongs to the aldehyde dehydrogenase family
I33_4146	COG1349	DNA-binding transcription factor activity
I33_4147	COG0667	Aldo Keto reductase
I33_4152	COG2814	Major facilitator Superfamily
I33_4153	COG0326	Molecular chaperone. Has ATPase activity
I33_4155	COG1028	Short-chain dehydrogenase reductase Sdr
I33_4156	COG1309	transcriptional regulator
I33_4157	COG1012	belongs to the aldehyde dehydrogenase family
I33_4159	COG0789	Transcriptional regulator
I33_4160	COG1714	RDD family
I33_4161	COG2311	Membrane
I33_4162	COG1917	Cupin 2, conserved barrel domain protein
I33_4163	COG1309	transcriptional regulator
I33_4164	COG1028	Short-chain dehydrogenase reductase Sdr
I33_4165	COG1846	Transcriptional regulator
I33_4166	COG1380	Effector of murein hydrolase LrgA
I33_4167	COG1346	cytolysis
I33_4168	COG5039	Polysaccharide pyruvyl transferase
I33_4169	COG1929	Belongs to the glycerate kinase type-1 family
I33_4170	COG1802	Transcriptional regulator
I33_4171	COG1070	Carbohydrate kinase
I33_4172	COG2610	gluconate transmembrane transporter activity
I33_4173	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I33_4174	COG0450	alkyl hydroperoxide reductase
I33_4175	COG3634	alkyl hydroperoxide reductase activity
I33_4176	COG2723	6-phospho-beta-galactosidase activity
I33_4177	COG1263	PTS System
I33_4177	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_4177	COG2190	(PTS) system
I33_4178	COG2188	Transcriptional regulator
I33_4181	COG1131	(ABC) transporter
I33_4182	COG1994	Peptidase M50
I33_4183	COG0535	radical SAM domain protein
I33_4185	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I33_4187	COG2801	Transposase and inactivated derivatives
I33_4191	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I33_4194	COG1063	alcohol dehydrogenase
I33_4198	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I33_4199	COG0456	acetyltransferase
I33_4200	COG0457	Tetratricopeptide repeat
I33_4202	COG0010	Belongs to the arginase family
I33_4203	COG0833	amino acid
I33_4204	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I33_4205	COG3829	transcription factor binding
I33_4206	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I33_4207	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I33_4208	COG4853	Protein conserved in bacteria
I33_4209	COG4863	YycH protein
I33_4210	COG5002	protein histidine kinase activity
I33_4211	COG0745	RESPONSE REGULATOR receiver
I33_4217	COG0346	lactoylglutathione lyase activity
I33_4218	COG0305	Participates in initiation and elongation during chromosome replication
I33_4221	COG3093	addiction module antidote protein HigA
I33_4222	COG2807	transmembrane transport
I33_4223	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I33_4224	COG0359	binds to the 23S rRNA
I33_4225	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I33_4226	COG4241	membrane
I33_4229	COG5577	PFAM Coat F domain
I33_4230	COG1733	regulation of RNA biosynthetic process
I33_4231	COG1227	inorganic diphosphatase activity
I33_4234	COG2271	Major facilitator Superfamily
I33_4235	COG4978	Transcriptional regulator
I33_4235	COG0789	Transcriptional regulator
I33_4237	COG4319	ketosteroid isomerase
I33_4238	COG1357	PFAM Pentapeptide repeats (8 copies)
I33_4239	COG2814	Major facilitator Superfamily
I33_4240	COG0583	DNA-binding transcription factor activity
I33_4241	COG2153	protein acetylation
I33_4243	COG0583	DNA-binding transcription factor activity
I33_4247	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_4248	COG1846	Transcriptional regulator
I33_4249	COG2153	protein acetylation
I33_4250	COG2364	Membrane
I33_4252	COG1331	Highly conserved protein containing a thioredoxin domain
I33_4253	COG1266	CAAX protease self-immunity
I33_4254	COG2814	Major facilitator Superfamily
I33_4254	COG0477	Major facilitator Superfamily
I33_4255	COG0110	maltose O-acetyltransferase activity
I33_4256	COG0346	lactoylglutathione lyase activity
I33_4257	COG1609	Transcriptional regulator
I33_4258	COG0708	Exodeoxyribonuclease III
I33_4259	COG0629	single-stranded DNA binding
I33_4260	COG0360	Binds together with S18 to 16S ribosomal RNA
I33_4261	COG0012	GTP binding
I33_4262	COG0243	molybdopterin cofactor binding
I33_4263	COG4481	Protein conserved in bacteria
I33_4264	COG3949	Membrane
I33_4266	COG1475	DNA binding
I33_4267	COG1192	Involved in chromosome partitioning
I33_4269	COG1475	DNA binding
I33_4270	COG0357	Ribosomal RNA small subunit methyltransferase G
I33_4271	COG0445	tRNA wobble uridine modification
I33_4272	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I33_4273	COG1847	R3H domain protein
I33_4274	COG0706	membrane insertase activity
I33_4275	COG0594	ribonuclease P activity