locus-tag class description HCN55_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HCN55_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HCN55_00015 ENOG410848D S4 domain protein YaaA HCN55_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HCN55_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HCN55_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HCN55_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HCN55_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HCN55_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HCN55_00110 ENOG41067KS pro-sigma K processing HCN55_00150 ENOG4105CDW Resistance protein HCN55_00155 ENOG4105CXN decarboxylase HCN55_00160 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HCN55_00165 ENOG4105X0R protein from nitrogen regulatory protein P-II HCN55_00170 ENOG4105XVJ Protein of unknown function (DUF327) HCN55_00175 ENOG4105FA2 dna polymerase iii HCN55_00180 ENOG4105MA4 psp1 domain protein HCN55_00185 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) HCN55_00190 ENOG41060K3 Methyltransferase HCN55_00195 ENOG4105VC4 domain protein HCN55_00200 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HCN55_00205 ENOG4105KRN Transcriptional regulator, abrb family HCN55_00210 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HCN55_00215 ENOG4105F8V Hydrolase, tatD family HCN55_00220 ENOG41069ER domain protein HCN55_00230 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HCN55_00235 ENOG4105XFA sporulation peptidase YabG HCN55_00240 ENOG4105W42 Veg protein HCN55_00245 ENOG4105XEW small acid-soluble spore protein HCN55_00250 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HCN55_00255 ENOG4105DFT pur operon repressor HCN55_00260 ENOG4105KME endoribonuclease L-psp HCN55_00265 ENOG4105K4W Could be involved in septation (By similarity) HCN55_00270 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HCN55_00275 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HCN55_00280 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HCN55_00285 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HCN55_00295 ENOG4108JA2 transcriptioN-repair coupling factor HCN55_00300 ENOG4108M14 stage v sporulation protein t HCN55_00310 ENOG4108IY2 MazG family HCN55_00315 ENOG41082I2 s4 domain protein HCN55_00320 ENOG4105VYY sporulation protein yabp HCN55_00335 ENOG41060GV RNA binding s1 domain protein HCN55_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HCN55_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase HCN55_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HCN55_00385 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HCN55_00390 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HCN55_00395 ENOG4105C6T cysteine synthase HCN55_00400 ENOG4105CRQ synthase (Component I) HCN55_00405 ENOG4105DDQ anthranilate synthase HCN55_00410 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HCN55_00415 ENOG4105EEI dihydropteroate synthase HCN55_00420 ENOG4105KRF dihydroneopterin aldolase HCN55_00425 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HCN55_00435 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HCN55_00440 ENOG4105CRK lysyL-tRNA synthetase HCN55_00525 ENOG4108Z0C Uvrb UvrC protein HCN55_00530 ENOG41066A3 ATP guanido phosphotransferase HCN55_00540 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HCN55_00545 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HCN55_00550 ENOG4105CTP PilT protein domain protein HCN55_00555 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HCN55_00560 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HCN55_00565 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HCN55_00570 ENOG4105D7W serine acetyltransferase HCN55_00575 ENOG4105C8N cysteinyl-tRNA synthetase HCN55_00580 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HCN55_00585 ENOG4105C2N RNA methyltransferase TrmH family group 3 HCN55_00590 ENOG4105M0M Tetracycline resistance protein HCN55_00610 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HCN55_00625 ENOG4108VZM 50s ribosomal protein L10 HCN55_00635 ENOG4107Y49 methyltransferase HCN55_00640 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HCN55_00645 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HCN55_00650 ENOG4105XPM ribosomal protein HCN55_00655 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HCN55_00660 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HCN55_00665 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HCN55_00670 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HCN55_00675 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HCN55_00680 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HCN55_00685 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HCN55_00690 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HCN55_00700 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HCN55_00715 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HCN55_00720 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HCN55_00730 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HCN55_00735 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HCN55_00745 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HCN55_00755 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HCN55_00760 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HCN55_00765 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HCN55_00770 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HCN55_00780 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HCN55_00785 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HCN55_00795 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HCN55_00810 ENOG41067V7 50S ribosomal protein L36 HCN55_00815 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HCN55_00820 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HCN55_00825 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HCN55_00830 ENOG4108ZT0 50S ribosomal protein l17 HCN55_00835 ENOG4108JJB ABC transporter HCN55_00840 ENOG4108JJB ABC transporter HCN55_00845 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HCN55_00850 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HCN55_00855 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HCN55_00860 ENOG4108UJD 30S ribosomal protein S9 HCN55_00865 ENOG4108I0C methyltransferase HCN55_00880 ENOG4105D1F ATP-binding protein HCN55_00895 ENOG4108NMV polysaccharide deacetylase HCN55_00975 ENOG4105CHH sulfate transporter HCN55_00985 ENOG4108SA1 esterase HCN55_01005 ENOG410874W AraC family transcriptional regulator HCN55_01010 ENOG4105EHZ conserved protein UCP016719 HCN55_01015 ENOG4105D17 glycoside hydrolase, family 3 domain protein HCN55_01035 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HCN55_01045 ENOG4105EWC Purine nucleoside phosphorylase HCN55_01075 ENOG4105EMN RNA polymerase sigma factor HCN55_01085 ENOG4105C8B TIGR00159 family HCN55_01090 ENOG4107U5W ybbr family HCN55_01095 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HCN55_01100 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HCN55_01110 ENOG4105D03 DNA-3-methyladenine glycosylase II HCN55_01120 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HCN55_01125 ENOG4108TWJ NADH dehydrogenase subunit 5 HCN55_01145 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HCN55_01150 ENOG4105WAB arsR family transcriptional regulator HCN55_01155 ENOG4108RWP Major Facilitator Superfamily protein HCN55_01170 ENOG4107ZBH radical SAM domain protein HCN55_01175 ENOG41066N6 Abortive infection protein HCN55_01180 ENOG4108WUZ (ABC) transporter HCN55_01220 ENOG4105G0J serine threonine protein kinase HCN55_01230 ENOG4106K80 HCN55_01240 ENOG4106DDH Sporulation-specific SASP protein HCN55_01250 ENOG4108HWY Beta-lactamase HCN55_01255 ENOG4107E6A Cytochrome p-450 HCN55_01265 ENOG4107QTZ amino acid HCN55_01270 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HCN55_01275 ENOG4105CXY transporter HCN55_01285 ENOG410645S MarR family Transcriptional regulator HCN55_01290 ENOG4105DCM major facilitator superfamily HCN55_01305 ENOG410631K Membrane HCN55_01310 ENOG4106AXJ AraC family transcriptional regulator HCN55_01315 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HCN55_01320 ENOG4108TCS Glutamyl endopeptidase HCN55_01330 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HCN55_01335 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HCN55_01340 ENOG4107ZTW SNARE associated Golgi HCN55_01365 ENOG4105C72 UPF0176 protein HCN55_01375 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane HCN55_01380 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HCN55_01395 ENOG4105CM2 brancheD-chain amino acid aminotransferase HCN55_01400 ENOG4108IQI permease HCN55_01405 ENOG4108J5H Homocysteine s-methyltransferase HCN55_01420 ENOG4105CSV Glutaminase HCN55_01435 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HCN55_01440 ENOG4105C26 Dehydrogenase HCN55_01445 ENOG4105DJB Major Facilitator Superfamily HCN55_01450 ENOG4105EQX glucarate dehydratase HCN55_01455 ENOG41073TP transcriptional regulator HCN55_01460 ENOG4105CTX dehydratase HCN55_01475 ENOG4106UX7 integral membrane protein HCN55_01480 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCN55_01515 ENOG4105MUA Resistance protein HCN55_01525 ENOG4105DGI Alkaline phosphatase HCN55_01530 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HCN55_01535 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HCN55_01540 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HCN55_01545 ENOG4107EPV Aminotransferase class V HCN55_01550 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCN55_01555 ENOG4105J7D transcriptional regulator HCN55_01560 ENOG4107RB3 L-asparaginase HCN55_01565 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HCN55_01575 ENOG41060AI SEC-C motif HCN55_01585 ENOG4107Y7X LytTR HCN55_01590 ENOG4108IUW ABC transporter HCN55_01595 ENOG4108SDH ABC, transporter HCN55_01600 ENOG4107SET aldo keto reductase HCN55_01635 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HCN55_01645 ENOG4105DSE periplasmic solute binding protein HCN55_01650 ENOG4105DIK (ABC) transporter HCN55_01660 ENOG4105DEN Luciferase family HCN55_01665 ENOG4108N0M stress protein HCN55_01670 ENOG4106FN3 tellurium resistance protein HCN55_01675 ENOG4106FN3 tellurium resistance protein HCN55_01680 ENOG4107TS3 membrane protein, TerC HCN55_01685 ENOG4108TTB tellurium resistance protein HCN55_01695 ENOG41079KZ Major Facilitator Superfamily HCN55_01700 ENOG4107XZQ multidrug resistance protein HCN55_01705 ENOG4108A65 Transcriptional regulator HCN55_01710 ENOG4108IJ7 Glycine betaine HCN55_01715 ENOG4107SQ8 Glycine betaine HCN55_01745 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HCN55_01780 ENOG4105EIG urea carboxylase-associated protein 1 HCN55_01785 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HCN55_01790 ENOG4105I1F Resistance protein HCN55_01795 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HCN55_01800 ENOG41089UC methyltransferase, type 11 HCN55_01805 ENOG4105C5Q Transcriptional regulator HCN55_01810 ENOG4105I82 acetyl xylan esterase HCN55_01815 ENOG410756H nucleotidyltransferase HCN55_01825 ENOG4105C26 Dehydrogenase HCN55_01830 ENOG4105CK7 Sodium proline symporter HCN55_01835 ENOG4107YHD transcriptional regulator HCN55_01845 ENOG4108PJD permease HCN55_01850 ENOG4105U6C Alpha beta hydrolase fold protein HCN55_01860 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HCN55_01865 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HCN55_01870 ENOG4108IFG nitrite reductase, (NAD(P)H) HCN55_01875 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HCN55_01895 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HCN55_01905 ENOG4105CKI cobalamin synthesis protein HCN55_01910 ENOG4105E5Q amino acid AbC transporter HCN55_01915 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein HCN55_01925 ENOG4105HHM rdd domain containing protein HCN55_01935 ENOG4105CS2 ec 3.2.1.21 HCN55_01950 ENOG4105C8Q Methyl-accepting chemotaxis HCN55_01955 ENOG41080HJ 6-phospho 3-hexuloisomerase HCN55_01960 ENOG4108VA3 3-hexulose-6-phosphate synthase HCN55_01965 ENOG4105KVH Transcriptional regulator HCN55_01970 ENOG4105CEY Amp-dependent synthetase and ligase HCN55_02000 ENOG4105SX7 Transporter HCN55_02020 ENOG4105CDA abc transporter atp-binding protein HCN55_02025 ENOG4105DRP amino acid AbC transporter HCN55_02035 ENOG4106P55 Transcriptional regulator HCN55_02040 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HCN55_02045 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HCN55_02050 ENOG41069ZX HCN55_02055 ENOG41069ZX HCN55_02065 ENOG4105DUX Transporter HCN55_02080 ENOG4105E1K spore germination protein HCN55_02100 ENOG4107WD8 ABC transporter, permease HCN55_02105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCN55_02110 ENOG4105BZU Histidine kinase HCN55_02135 ENOG4105CFH Aspartokinase HCN55_02140 ENOG4105DHS permease protein HCN55_02145 ENOG4105CM4 permease protein HCN55_02150 ENOG4108IPW abc transporter atp-binding protein HCN55_02165 ENOG4105R8C Transcriptional regulator HCN55_02170 ENOG4108DBC nitroreductase HCN55_02175 ENOG41067V3 Antibiotic biosynthesis monooxygenase HCN55_02180 ENOG4105YVS arsR family transcriptional regulator HCN55_02190 ENOG4108JPW Aminotransferase HCN55_02195 ENOG4105C26 Dehydrogenase HCN55_02205 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HCN55_02210 ENOG4105KTB nuclear export factor GLE1 HCN55_02215 ENOG4108T5E Copper resistance protein HCN55_02220 ENOG4108ZYE Transcriptional regulator HCN55_02245 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HCN55_02250 ENOG4108ZX0 Signal peptidase I HCN55_02275 ENOG4105E7W lamb ycsf family protein HCN55_02280 ENOG4105C5A transporter HCN55_02285 ENOG4105CFM UPF0317 protein HCN55_02290 ENOG4105P4J Allophanate hydrolase, subunit 1 HCN55_02300 ENOG4107258 Transcriptional regulator HCN55_02305 ENOG4105XJB lipolytic protein G-D-S-L family HCN55_02315 ENOG41061CK Antibiotic biosynthesis monooxygenase HCN55_02320 ENOG4107RVG penicillin-binding protein HCN55_02325 ENOG4107QM2 Aldo Keto reductase HCN55_02330 ENOG4105ETD TRANSCRIPTIONal HCN55_02340 ENOG4105HMZ Methyltransferase HCN55_02345 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HCN55_02360 ENOG410606W general stress protein HCN55_02370 ENOG4105VCH membrane HCN55_02380 ENOG4105C9U ATP-dependent DNA helicase RecQ HCN55_02395 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HCN55_02400 ENOG4107R8N Glycosyl transferase, family 2 HCN55_02410 ENOG4105C0X amino acid HCN55_02435 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HCN55_02445 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HCN55_02450 ENOG4105EU9 HCN55_02455 ENOG4105QVS general stress protein HCN55_02460 ENOG41082W1 Cupin 2, conserved barrel domain protein HCN55_02475 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HCN55_02480 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HCN55_02485 ENOG4108MRH transcriptional regulatory protein HCN55_02490 ENOG4107QJT sodium dicarboxylate symporter HCN55_02495 ENOG4106F5Q Membrane HCN55_02500 ENOG4105CJ1 ABC, transporter HCN55_02515 ENOG4105FDT acyl-CoA dehydrogenase HCN55_02535 ENOG4105SZ6 Thioredoxin HCN55_02540 ENOG4105CPF Cell wall formation (By similarity) HCN55_02545 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HCN55_02550 ENOG4105C1J atp-dependent rna helicase HCN55_02555 ENOG410905X membrane-flanked domain protein HCN55_02560 ENOG4105CKV Membrane HCN55_02570 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HCN55_02575 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HCN55_02580 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HCN55_02590 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HCN55_02595 ENOG4107MMM Anti-sigma-factor antagonist HCN55_02600 ENOG4105FUA antagonist HCN55_02605 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HCN55_02610 ENOG4107SGM protein serine threonine phosphatase HCN55_02615 ENOG4105WN5 stage II sporulation protein HCN55_02620 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HCN55_02630 ENOG41064BQ Phosphatase HCN55_02645 ENOG4105M5P UPF0310 protein HCN55_02650 ENOG4105RV9 Transcriptional regulator HCN55_02705 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HCN55_02710 ENOG41068WC Domain of unknown function (DUF955) HCN55_02715 ENOG4108IMY Transcriptional regulator HCN55_02740 ENOG4108RYM conjugative transposon protein HCN55_02745 ENOG4106BHR ftsk SpoIIIE family protein HCN55_02750 ENOG4106128 DNA-binding helix-turn-helix protein HCN55_02790 ENOG4105P1M Domain of unknown function (DUF1874) HCN55_02800 ENOG4105K4H Nlp p60 protein HCN55_02815 ENOG4108U3J HCN55_02830 ENOG41078D9 HCN55_02835 ENOG4105DEN Luciferase family HCN55_02850 ENOG4108W2Y isochorismatase HCN55_02855 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HCN55_02860 ENOG4108HH4 Major Facilitator Superfamily HCN55_02880 ENOG4108V4B ThiJ pfpI HCN55_02885 ENOG4105VEQ Cold shock protein HCN55_02900 ENOG4108MCI Transcriptional regulator, ARAC family HCN55_02905 ENOG4108UZ3 Transporter HCN55_02910 ENOG41086D8 Transcriptional regulator HCN55_02915 ENOG4107U9B transcriptional regulator HCN55_02920 ENOG4105DXI Major Facilitator superfamily HCN55_02930 ENOG4105CZ9 Domain of unknown function (DU1801) HCN55_02935 ENOG4105GIG HCN55_02940 ENOG4105T38 integral membrane protein HCN55_02945 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HCN55_02950 ENOG4108ZMQ domain protein HCN55_02955 ENOG4105MJ9 esterase HCN55_02960 ENOG4107Z6X Transcriptional regulator HCN55_02970 ENOG4105KVH Transcriptional regulator HCN55_02975 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HCN55_02980 ENOG4105EQ0 Major Facilitator superfamily HCN55_02985 ENOG4108JGH Tetr family transcriptional regulator HCN55_02995 ENOG41082YX Transcriptional regulator, arsr family HCN55_03000 ENOG4107R5R arsenical pump membrane protein HCN55_03010 ENOG4105Z7P Acetyltransferase (GNAT) family HCN55_03015 ENOG4107Y9U Membrane HCN55_03025 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HCN55_03030 ENOG4108ZHR arsR family transcriptional regulator HCN55_03035 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HCN55_03050 ENOG4105ENE Histidine kinase HCN55_03055 ENOG4108VB1 regulatoR HCN55_03060 ENOG4105EYF MMPL domain protein HCN55_03065 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HCN55_03070 ENOG4108UQV Membrane HCN55_03075 ENOG4108Z5V transcriptional regulator, merr family HCN55_03080 ENOG41076HS cation diffusion facilitator family transporter HCN55_03085 ENOG4108TVJ Nitroreductase HCN55_03090 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HCN55_03095 ENOG4108VGI doxx family HCN55_03100 ENOG4105XXY Thioredoxin HCN55_03120 ENOG410900G Protein of unknown function (DUF421) HCN55_03125 ENOG4108QY0 Membrane HCN55_03145 ENOG4105PF9 Transcriptional regulator HCN55_03155 ENOG4105WQG acetyltransferase HCN55_03165 ENOG4105C85 amino acid HCN55_03175 ENOG41062A4 Transcriptional regulator HCN55_03180 ENOG4105EYF MMPL domain protein HCN55_03185 ENOG4108TVJ Nitroreductase HCN55_03190 ENOG4105FS7 Transcriptional regulator HCN55_03195 ENOG4105C2C drug resistance transporter, Bcr CflA HCN55_03205 ENOG4105DRR Transcriptional regulator, GntR family HCN55_03210 ENOG4105VRS hydrolase family 18 HCN55_03225 ENOG4105G6Z alkaline phosphatase HCN55_03230 ENOG4108ZMX Domain of unknown function (DU1801) HCN55_03240 ENOG4108YM7 Gcn5-related n-acetyltransferase HCN55_03245 ENOG4107TVP HD domain protein HCN55_03250 ENOG41090UD (LipO)protein HCN55_03255 ENOG4105F27 Major Facilitator HCN55_03260 ENOG4105VZJ PTS System HCN55_03265 ENOG4105VCP PTS System HCN55_03270 ENOG4105CK1 PTS System HCN55_03275 ENOG4105CS2 ec 3.2.1.21 HCN55_03280 ENOG4108TZY GntR Family Transcriptional Regulator HCN55_03285 ENOG4105EVU fructokinase HCN55_03290 ENOG4105DG6 mannose-6-phosphate isomerase HCN55_03295 ENOG4105D3P Mannan endo-1,4-beta-mannosidase HCN55_03340 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HCN55_03345 ENOG4105K8N protein family UPF0079, ATPase HCN55_03350 ENOG41072GX Peptidase M22 Glycoprotease HCN55_03355 ENOG410801F ribosomal-protein-alanine acetyltransferase HCN55_03360 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HCN55_03365 ENOG4105C5H ABC transporter HCN55_03370 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HCN55_03375 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HCN55_03380 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HCN55_03385 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HCN55_03395 ENOG4108TYN CAAX amino terminal protease family protein HCN55_03405 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HCN55_03430 ENOG4105DVF Cytosine-specific methyltransferase HCN55_03435 ENOG4107RHI Cytosine-specific methyltransferase HCN55_03470 ENOG4105PGZ NB-ARC domain HCN55_03475 ENOG4105CPQ Dehydrogenase HCN55_03480 ENOG4105CT4 transporter HCN55_03490 ENOG41087YS Phage shock protein A HCN55_03495 ENOG4105DQX Zinc finger domain HCN55_03500 ENOG4108WV1 Pfam:DUF477 HCN55_03510 ENOG4108ZMR Ion transport 2 domain-containing protein HCN55_03515 ENOG4107QNK )-transporter HCN55_03545 ENOG4107YUH hydrolase HCN55_03555 ENOG4107STQ Multicopper oxidase HCN55_03560 ENOG4105C85 amino acid HCN55_03575 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HCN55_03595 ENOG4105C7N Xanthine uracil vitamin C permease HCN55_03620 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HCN55_03625 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HCN55_03630 ENOG4105C83 adenylosuccinate lyase HCN55_03635 ENOG4105C8V SAICAR synthetase HCN55_03640 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HCN55_03645 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HCN55_03650 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HCN55_03660 ENOG4105CXB phosphoribosylaminoimidazole synthetase HCN55_03665 ENOG4108V3E phosphoribosylglycinamide formyltransferase HCN55_03670 ENOG4105DC1 bifunctional purine biosynthesis protein purh HCN55_03675 ENOG4105C12 Phosphoribosylglycinamide synthetase HCN55_03685 ENOG4105DVH amino acid HCN55_03700 ENOG4108R5T secreted protein HCN55_03705 ENOG4105KGF protein, YerC YecD HCN55_03710 ENOG4105CBC glutamate synthase HCN55_03715 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HCN55_03720 ENOG4105C4R Atp-dependent dna helicase HCN55_03725 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HCN55_03735 ENOG4105CRN Aminoglycoside phosphotransferase HCN55_03740 ENOG4105KT7 mgtC SapB transporter HCN55_03745 ENOG4105CK7 Sodium proline symporter HCN55_03750 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HCN55_03755 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HCN55_03760 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HCN55_03765 ENOG4108IG5 Transcriptional regulator HCN55_03775 ENOG4105CBD Diacylglycerol kinase HCN55_03780 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HCN55_03795 ENOG4105D85 methylase HCN55_03800 ENOG4105F6A helicase HCN55_03805 ENOG4105ECI YeeC-like protein HCN55_03845 ENOG4105CDY transcriptional regulatory protein HCN55_03855 ENOG4105M4P Tetr family transcriptional regulator HCN55_03860 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HCN55_03865 ENOG4107S9F NmrA family HCN55_03880 ENOG4105WEF catalase HCN55_03885 ENOG4105M18 -acetyltransferase HCN55_03900 ENOG4105C2F Histidine kinase HCN55_03905 ENOG4105EQD regulatoR HCN55_03910 ENOG410769Z extracellular solute-binding protein family 1 HCN55_03915 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HCN55_03920 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HCN55_03925 ENOG4105F5H Glycosyl Hydrolase Family 88 HCN55_03930 ENOG41075H3 AraC family transcriptional regulator HCN55_03935 ENOG4107TDE lipolytic protein G-D-S-L family HCN55_03950 ENOG4105CX8 fg-gap repeat protein HCN55_03955 ENOG4105CX8 fg-gap repeat protein HCN55_03960 ENOG4107TDE lipolytic protein G-D-S-L family HCN55_03970 ENOG4105EKC HCN55_03975 ENOG4105E0S extracellular solute-binding protein family 1 HCN55_03985 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HCN55_03990 ENOG4105F8D glycoside hydrolase family 4 HCN55_03995 ENOG4105H67 Protein of unknown function (DUF421) HCN55_04000 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HCN55_04005 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HCN55_04025 ENOG4106I4J membrane HCN55_04030 ENOG4108PCN EamA-like transporter family HCN55_04035 ENOG41082F9 transcriptional regulator HCN55_04040 ENOG41061H0 Monooxygenase HCN55_04045 ENOG4108R1P HCN55_04050 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HCN55_04055 ENOG4105E0M Sulfatase HCN55_04060 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HCN55_04070 ENOG41090R9 glycosyltransferase HCN55_04075 ENOG4107R51 Glycosyl transferase, family 2 HCN55_04080 ENOG41090R9 glycosyltransferase HCN55_04085 ENOG4105EU0 Major facilitator Superfamily HCN55_04095 ENOG4105CUB amino acid HCN55_04100 ENOG4105C26 Dehydrogenase HCN55_04105 ENOG4105FKZ Methyl-accepting chemotaxis HCN55_04110 ENOG4105C5H ABC transporter HCN55_04120 ENOG4107SWG transcriptional regulator MERR family HCN55_04125 ENOG4105DXB Major Facilitator superfamily HCN55_04135 ENOG4105C5H ABC transporter HCN55_04140 ENOG4105FDU atp-dependent rna helicase HCN55_04150 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HCN55_04160 ENOG4105E6M Sulphatase-modifying factor protein HCN55_04165 ENOG4105E0A ABC, transporter HCN55_04170 ENOG4108U1V ABC transporter, permease HCN55_04175 ENOG4105DQ5 transport system permease protein HCN55_04180 ENOG4108HUF Transporter HCN55_04195 ENOG4108J20 pectate lyase HCN55_04200 ENOG4107QPK )-transporter HCN55_04210 ENOG4108MRH transcriptional regulatory protein HCN55_04235 ENOG410855V Acylphosphatase HCN55_04240 ENOG4108RPX mosc domain containing protein HCN55_04260 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HCN55_04290 ENOG4105GEU Spore germination protein HCN55_04300 ENOG4108Q5U germination protein, ger(x)c family HCN55_04305 ENOG4105E1K spore germination protein HCN55_04310 ENOG4105C5Y PTS System HCN55_04315 ENOG4105CG3 alpha amylase, catalytic region HCN55_04320 ENOG4107414 GntR family transcriptional regulator HCN55_04325 ENOG4108RCM Nitroreductase HCN55_04330 ENOG4105CGH 5'-nucleotidase HCN55_04335 ENOG4107RKG DJ-1/PfpI family HCN55_04350 ENOG4105KJF protein tyrosine phosphatase HCN55_04360 ENOG4107U9T Pfam:Ribonuclease_BN HCN55_04365 ENOG4108ISG Major Facilitator HCN55_04370 ENOG4105UPD Calcium Proton HCN55_04380 ENOG4105D8X mechanosensitive ion channel HCN55_04400 ENOG4106KE4 Dehydrogenase HCN55_04405 ENOG4105D7N magnesium and cobalt transport protein CorA HCN55_04415 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HCN55_04440 ENOG4107RUY (E1 component), alpha subunit HCN55_04450 ENOG4107QKR Dehydrogenase HCN55_04460 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HCN55_04465 ENOG41069DP small acid-soluble spore protein HCN55_04470 ENOG4105KK4 UPF0060 membrane protein HCN55_04500 ENOG4105F8D glycoside hydrolase family 4 HCN55_04505 ENOG4108Q3X Transcriptional regulator HCN55_04510 ENOG4105CI1 PTS System HCN55_04515 ENOG4105BZ1 (ABC) transporter HCN55_04520 ENOG4105BZ1 (ABC) transporter HCN55_04530 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HCN55_04535 ENOG4105ID8 Transcriptional regulator, ARAC family HCN55_04540 ENOG4107QNK )-transporter HCN55_04545 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HCN55_04550 ENOG4105CIB oxidoreductase Domain protein HCN55_04555 ENOG4105BZU Histidine kinase HCN55_04560 ENOG4105WH1 Two component transcriptional regulator luxr family HCN55_04565 ENOG4105CJ1 ABC, transporter HCN55_04570 ENOG41090VJ ABC-2 type transporter HCN55_04575 ENOG4108KYE ABC-2 type transporter HCN55_04580 ENOG4105U3E Transcriptional regulator HCN55_04585 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HCN55_04590 ENOG4105H93 Acyltransferase family HCN55_04595 ENOG4105YA8 Transcriptional regulator HCN55_04600 ENOG4107Y80 Major Facilitator superfamily HCN55_04605 ENOG4108YYS metal-dependent hydrolase (By similarity) HCN55_04610 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCN55_04615 ENOG410834F Transcriptional regulator HCN55_04625 ENOG4108MES Periplasmic binding protein HCN55_04630 ENOG4105DQ5 transport system permease protein HCN55_04635 ENOG4108IHU transport system permease protein HCN55_04640 ENOG4105JAB phenazine biosynthesis protein, phzf family HCN55_04645 ENOG4107Y03 Nitroreductase HCN55_04660 ENOG4105ECP epimerase HCN55_04675 ENOG4105F27 Major Facilitator HCN55_04695 ENOG4106AKJ HCN55_04700 ENOG4105D74 hydrolase HCN55_04705 ENOG4105CKK Glycosyl transferase, family 2 HCN55_04710 ENOG4105EJV Membrane HCN55_04715 ENOG41067AE Membrane-bound metal-dependent hydrolase HCN55_04720 ENOG4105CEN a g-specific adenine glycosylase HCN55_04725 ENOG4106BXE HCN55_04730 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HCN55_04745 ENOG4105EVI UPF0374 protein HCN55_04750 ENOG4105BZ1 (ABC) transporter HCN55_04755 ENOG4107NBY Membrane HCN55_04765 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HCN55_04770 ENOG4105G5W regulator Fur family HCN55_04880 ENOG4108N23 SpoOM-related protein HCN55_04895 ENOG4105EC3 peptidase S51, dipeptidase E HCN55_04900 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HCN55_04905 ENOG4105DNP FAD linked oxidase domain protein HCN55_04920 ENOG4105E2Y ABC, transporter HCN55_04925 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HCN55_04930 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HCN55_04935 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HCN55_04945 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HCN55_04950 ENOG4107D63 HCN55_04955 ENOG4105VZ8 Transcriptional regulator HCN55_04970 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HCN55_04980 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HCN55_05000 ENOG4105CYN Serine protein kinase HCN55_05005 ENOG4106AKX UPF0229 protein HCN55_05010 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HCN55_05015 ENOG4105CW7 secretion protein, HlyD family HCN55_05020 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCN55_05025 ENOG4105CS1 NAD(P)H quinone oxidoreductase HCN55_05045 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HCN55_05050 ENOG4105CZV ABC transporter HCN55_05055 ENOG4105CJ1 ABC, transporter HCN55_05060 ENOG4108TU7 Inherit from COG: (ABC) transporter HCN55_05065 ENOG4105VEQ Cold shock protein HCN55_05075 ENOG4105BZU Histidine kinase HCN55_05115 ENOG4108YBP pseudouridine synthase HCN55_05125 ENOG41080XP Cbs domain HCN55_05130 ENOG4107YBY Hydrolase HCN55_05135 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HCN55_05140 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HCN55_05145 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HCN55_05155 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HCN55_05160 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HCN55_05170 ENOG4105BZU Histidine kinase HCN55_05175 ENOG4105WH1 Two component transcriptional regulator luxr family HCN55_05210 ENOG4105ED1 spovr family HCN55_05215 ENOG4105G6Z alkaline phosphatase HCN55_05230 ENOG4105BZN citrate synthase HCN55_05235 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HCN55_05240 ENOG4105CUB amino acid HCN55_05245 ENOG4105C8J )-transporter HCN55_05250 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HCN55_05265 ENOG4105J37 HCN55_05270 ENOG4108AEY RNA polymerase sigma factor HCN55_05275 ENOG4108FN7 Aldo keto reductase HCN55_05280 ENOG4105F6E Acyl-transferase HCN55_05285 ENOG4105C37 (CBS) domain HCN55_05295 ENOG4105CHM Aminotransferase HCN55_05300 ENOG4105C37 (CBS) domain HCN55_05310 ENOG4105WMR Protein CrcB homolog HCN55_05315 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HCN55_05325 ENOG4105D64 Mechanosensitive ion channel HCN55_05330 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HCN55_05335 ENOG4107VMI polysaccharide deacetylase HCN55_05340 ENOG4105F0I Aminotransferase HCN55_05360 ENOG4105BZ1 (ABC) transporter HCN55_05365 ENOG4105BZ1 (ABC) transporter HCN55_05390 ENOG410839P HCN55_05400 ENOG4106MP8 UPF0754 membrane protein HCN55_05405 ENOG4105WZB UPF0342 protein HCN55_05410 ENOG4105F1N DNA alkylation repair HCN55_05420 ENOG4105D4P Coproporphyrinogen iii oxidase HCN55_05425 ENOG4107S91 Sodium hydrogen exchanger HCN55_05430 ENOG4105NCW Trka-c domain protein HCN55_05440 ENOG4105CGU Enoyl-CoA hydratase HCN55_05450 ENOG4108IUX (ABC) transporter HCN55_05455 ENOG4105RHA ABC transporter, permease HCN55_05460 ENOG4107VRP DNA repair exonuclease HCN55_05465 ENOG4106D4I domain protein HCN55_05470 ENOG4105EQI Metal Dependent Phosphohydrolase HCN55_05480 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HCN55_05525 ENOG4105NBU tryptophan transport protein HCN55_05530 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HCN55_05535 ENOG4105K59 histidine triad (HIT) protein HCN55_05570 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HCN55_05575 ENOG4105BZ4 penicillin-binding protein HCN55_05580 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HCN55_05585 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HCN55_05590 ENOG4105C1Q protoporphyrinogen oxidase HCN55_05600 ENOG4105ECB domain protein HCN55_05610 ENOG41090T1 Membrane HCN55_05620 ENOG4105DER m42 family HCN55_05635 ENOG4106AXD HCN55_05640 ENOG4108RQ5 Beta-lactamase domain-containing protein HCN55_05645 ENOG4105DF9 Lipoate-protein, ligase HCN55_05655 ENOG4105CEY Amp-dependent synthetase and ligase HCN55_05665 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HCN55_05670 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCN55_05675 ENOG4105KD7 acetyltransferase HCN55_05685 ENOG4108HUF Transporter HCN55_05690 ENOG4107TB6 phosphoglycerate mutase HCN55_05700 ENOG4107F3J Amp-dependent synthetase and ligase HCN55_05705 ENOG4107ZYJ bioY protein HCN55_05710 ENOG4106YBV Methyl-accepting chemotaxis HCN55_05730 ENOG4105XVF Competence transcription factor HCN55_05735 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HCN55_05740 ENOG4105X3H Excalibur domain protein HCN55_05745 ENOG4105E1V na solute symporter HCN55_05750 ENOG4106CAD Protein of unknown function (DUF3311) HCN55_05755 ENOG41060YP HCN55_05770 ENOG4107SCK Monooxygenase HCN55_05775 ENOG4108INS Transcriptional regulator HCN55_05790 ENOG4105TRI Hydrolase HCN55_05805 ENOG4108KK1 membrane protein AbrB duplication HCN55_05810 ENOG4106K7D Major facilitator family transporter HCN55_05815 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HCN55_05820 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding HCN55_05835 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HCN55_05845 ENOG4105EYH Exonuclease HCN55_05895 ENOG4105ERH Fumarylacetoacetate hydrolase HCN55_05905 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCN55_05915 ENOG4105CAQ asparagine synthetase HCN55_05930 ENOG4105UQX Mate efflux family protein HCN55_05935 ENOG4106HBX Transcriptional Regulator AraC Family HCN55_05940 ENOG4105ETE Transcriptional regulator (LacI family HCN55_05945 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HCN55_05950 ENOG4105SF0 DinB family HCN55_05955 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HCN55_05960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HCN55_05965 ENOG4105MYW Pentapeptide repeat protein HCN55_05970 ENOG4107S9D Alpha beta hydrolase HCN55_05975 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HCN55_05980 ENOG4107RIQ Sulfate adenylate transferase HCN55_05985 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HCN55_05990 ENOG4108N5B 2-phosphosulfolactate phosphatase HCN55_05995 ENOG41061P3 phosphosulfolactate synthase HCN55_06005 ENOG4105DIA mandelate racemase muconate lactonizing HCN55_06010 ENOG4107RCC Major Facilitator Superfamily HCN55_06015 ENOG4108SZE gCN5-related N-acetyltransferase HCN55_06020 ENOG4105MA6 gCN5-related N-acetyltransferase HCN55_06030 ENOG4108VPT UPF0234 protein HCN55_06035 ENOG4105QNR S1 RNA binding domain protein HCN55_06055 ENOG4105K7K Transcriptional regulator HCN55_06065 ENOG410751J HCN55_06070 ENOG4105D4Y metalloprotease HCN55_06075 ENOG4105EPR degv family HCN55_06080 ENOG4107AYK membrAne HCN55_06090 ENOG41073B9 HCN55_06100 ENOG4108KP7 hydrolase HCN55_06105 ENOG4108MXZ Esterase HCN55_06110 ENOG4105VG1 fes assembly suf system protein HCN55_06120 ENOG4105IQ5 FAD linked oxidase domain protein HCN55_06130 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HCN55_06135 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HCN55_06145 ENOG4105C8Y Acetylornithine aminotransferase HCN55_06150 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HCN55_06160 ENOG4105DBV ornithine carbamoyltransferase HCN55_06185 ENOG4107RMD Basic membrane lipoprotein HCN55_06200 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HCN55_06205 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HCN55_06215 ENOG4105C3U ABC transporter HCN55_06220 ENOG4108JQ7 (ABC) transporter HCN55_06235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCN55_06245 ENOG4105C31 Tryptophanyl-tRNA synthetase HCN55_06250 ENOG4108J59 Extracellular solute-binding protein, family 5 HCN55_06255 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HCN55_06260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCN55_06270 ENOG4108JQ7 (ABC) transporter HCN55_06285 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HCN55_06290 ENOG4108ZCF integral membrane protein HCN55_06300 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HCN55_06315 ENOG4105DPN Oligoendopeptidase f HCN55_06325 ENOG4105T58 Dithiol-disulfide isomerase HCN55_06330 ENOG4108Z18 K06886 hemoglobin HCN55_06335 ENOG4105E4C Lytic transglycosylase catalytic HCN55_06340 ENOG4105MIX Adenylate cyclase HCN55_06355 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HCN55_06360 ENOG4105EMS pseudouridine synthase HCN55_06375 ENOG4105ETU transcriptional activator (TenA HCN55_06380 ENOG4108VEU Thiamine monophosphate synthase HCN55_06395 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HCN55_06400 ENOG4105D06 uba thif-type nad fad binding protein HCN55_06405 ENOG4105DWF phosphomethylpyrimidine kinase HCN55_06410 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HCN55_06415 ENOG4107A88 HCN55_06465 ENOG4105ENA helicase HCN55_06480 ENOG4108ZMI UPF0477 protein HCN55_06490 ENOG4105C28 cystathionine HCN55_06495 ENOG4105C28 cystathionine HCN55_06500 ENOG4105D9U N-acetyltransferase HCN55_06505 ENOG4105JHY Membrane HCN55_06515 ENOG41068SY HCN55_06535 ENOG4107KNS HCN55_06560 ENOG4108PSK reductase HCN55_06575 ENOG4105DM4 PTS System HCN55_06580 ENOG4105DG6 mannose-6-phosphate isomerase HCN55_06585 ENOG4105G7B Protein of unknown function (DUF2992) HCN55_06590 ENOG4105VMI -acetyltransferase HCN55_06600 ENOG4108Z66 YbaK ebsC protein HCN55_06615 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HCN55_06625 ENOG4108ZJ4 polysaccharide deacetylase HCN55_06630 ENOG4107CUJ Protein of unknown function (DUF2690) HCN55_06655 ENOG4108IEG Formate dehydrogenase Alpha subunit HCN55_06680 ENOG4106A3M Cytochrome p-450 HCN55_06685 ENOG41087PP glycosyltransferase MGT family HCN55_06695 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HCN55_06700 ENOG4105C4B ABC transporter, permease HCN55_06705 ENOG4108IXI (ABC) transporter HCN55_06715 ENOG4105Q95 Cupin 2, conserved barrel domain protein HCN55_06730 ENOG4105D2H Uronic isomerase HCN55_06735 ENOG4105CT4 transporter HCN55_06740 ENOG4105DG4 malate L-lactate dehydrogenase HCN55_06745 ENOG4105CPQ Dehydrogenase HCN55_06750 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HCN55_06755 ENOG4105DMW Dehydrogenase reductase HCN55_06760 ENOG4108I5G Major Facilitator superfamily HCN55_06765 ENOG4107KJX Transcriptional regulator HCN55_06770 ENOG4107QZW Altronate oxidoreductase HCN55_06775 ENOG4105CTX dehydratase HCN55_06780 ENOG4107TSN permease HCN55_06790 ENOG4105JD4 ATPase yjob HCN55_06805 ENOG41068K0 YCII-related domain HCN55_06810 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HCN55_06815 ENOG4105KWG Pfam:DUF1696 HCN55_06820 ENOG4105K7W phage-related replication protein HCN55_06825 ENOG4105WEF catalase HCN55_06830 ENOG410635T phage-like element pbsx protein HCN55_06875 ENOG4108TFU terminase (Small subunit) HCN55_06880 ENOG4105IG6 Phage terminase, large subunit HCN55_06885 ENOG4108MDF Phage Portal Protein HCN55_06910 ENOG41060SN HCN55_06925 ENOG4105PQS phage protein HCN55_06930 ENOG4105FR7 XkdM protein, phage-like element PBSX HCN55_06935 ENOG4105MTC XkdN-like protein HCN55_06945 ENOG4108FKH Transglycosylase SLT domain HCN55_06950 ENOG4108WZM domain protein HCN55_06955 ENOG4105X7F HCN55_06965 ENOG4105MFU Protein of unknown function (DUF2634) HCN55_06970 ENOG41066EA baseplate J family protein HCN55_06975 ENOG410906S phage-like element pbsx protein xkdt HCN55_06985 ENOG41068G1 HCN55_07015 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HCN55_07035 ENOG4105CJ3 phosphate transporter HCN55_07040 ENOG4107GRR phosphate transport regulator HCN55_07045 ENOG4107R7I amino acid HCN55_07060 ENOG4105EDW glycosyl transferase, family 39 HCN55_07065 ENOG4105CKK Glycosyl transferase, family 2 HCN55_07075 ENOG4105C0H protease HCN55_07085 ENOG4108ME1 Peptidase M55 D-aminopeptidase HCN55_07090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HCN55_07095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCN55_07100 ENOG4105C3U ABC transporter HCN55_07110 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HCN55_07115 ENOG4105DTQ mandelate racemase muconate lactonizing HCN55_07120 ENOG4107SN7 NLP P60 protein HCN55_07125 ENOG4108JQ7 (ABC) transporter HCN55_07130 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HCN55_07135 ENOG4107TUM Amidinotransferase HCN55_07140 ENOG4108S4H thioesterase Superfamily protein HCN55_07145 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HCN55_07165 ENOG4108428 Inherit from COG: -acetyltransferase HCN55_07175 ENOG41080TC multidrug resistance protein HCN55_07180 ENOG4105CIY formyltetrahydrofolate deformylase HCN55_07185 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HCN55_07200 ENOG4105K56 Transcriptional regulator HCN55_07205 ENOG4108ZHJ Organic hydroperoxide resistance protein HCN55_07215 ENOG4107Y2X deaminase HCN55_07220 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HCN55_07225 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCN55_07235 ENOG4108W7F transporter, permease HCN55_07240 ENOG4108JJB ABC transporter HCN55_07245 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HCN55_07250 ENOG4108X43 YKOF domain protein HCN55_07255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCN55_07260 ENOG41062D9 Histidine kinase HCN55_07270 ENOG4106849 propeptide, pepSY amd peptidase M4 HCN55_07280 ENOG4105CJW magnesium transporter HCN55_07285 ENOG4105V75 Transcriptional regulator HCN55_07330 ENOG4105DQE DNA ligase HCN55_07335 ENOG4105FDF Could be involved in DNA repair (By similarity) HCN55_07340 ENOG4105BZU Histidine kinase HCN55_07345 ENOG4107T5V SNARE associated Golgi HCN55_07350 ENOG4107TS3 membrane protein, TerC HCN55_07355 ENOG4108WZW RNA polymerase sigma HCN55_07365 ENOG410681C small acid-soluble spore protein HCN55_07375 ENOG4105D0M Protease HtpX homolog HCN55_07395 ENOG4108TGC Acyltransferase HCN55_07400 ENOG4105BZU Histidine kinase HCN55_07405 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HCN55_07415 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HCN55_07420 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HCN55_07425 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HCN55_07435 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit HCN55_07440 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HCN55_07445 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HCN55_07450 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HCN55_07470 ENOG4105BZU Histidine kinase HCN55_07475 ENOG41090MY MarR family Transcriptional regulator HCN55_07480 ENOG4105ER2 Ompa motb domain protein HCN55_07485 ENOG4105E14 MotA TolQ exbB proton channel HCN55_07495 ENOG4108K88 Membrane HCN55_07500 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HCN55_07505 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HCN55_07510 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HCN55_07515 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HCN55_07525 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HCN55_07530 ENOG4105FEA Spore maturation protein HCN55_07560 ENOG4105F0V Cell wall hydrolase HCN55_07575 ENOG4105C59 p-type ATPase HCN55_07585 ENOG4105DC7 peptidase M24 HCN55_07595 ENOG4105CID antiterminator HCN55_07605 ENOG4105KRI phosphocarrier protein (HPr HCN55_07610 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HCN55_07620 ENOG4105F6S Spore photoproduct lyase HCN55_07630 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HCN55_07635 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HCN55_07640 ENOG4105K4I Scp-like extracellular HCN55_07650 ENOG4105BZU Histidine kinase HCN55_07655 ENOG4105CHM Aminotransferase HCN55_07665 ENOG4107R88 Chemotaxis protein (CheV) HCN55_07670 ENOG4105UIN HCN55_07680 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HCN55_07690 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HCN55_07695 ENOG4105ESF Peptidoglycan binding domain protein HCN55_07700 ENOG4105ESF Peptidoglycan binding domain protein HCN55_07710 ENOG4105EPM Diguanylate phosphodiesterase HCN55_07715 ENOG4107IN1 Protein of unknown function (DUF1797) HCN55_07720 ENOG4108XRC Protein of unknown function (DUF458) HCN55_07750 ENOG4105NQC Flavodoxin HCN55_07760 ENOG4105CH2 amidohydrolase HCN55_07770 ENOG4105D8X mechanosensitive ion channel HCN55_07775 ENOG4105D3R alkyl hydroperoxide reductase HCN55_07780 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HCN55_07795 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HCN55_07800 ENOG4105D06 uba thif-type nad fad binding protein HCN55_07805 ENOG4105CVM Molybdenum cofactor synthesis domain protein HCN55_07810 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HCN55_07815 ENOG4108ZAF Molybdopterin HCN55_07820 ENOG41067WU Molybdopterin converting factor (Subunit 1) HCN55_07825 ENOG4105BZ1 (ABC) transporter HCN55_07830 ENOG4105BZ1 (ABC) transporter HCN55_07840 ENOG4107X8C Efflux transporter RND family MFP subunit HCN55_07845 ENOG4105C19 ABC transporter HCN55_07850 ENOG4107RBB ABC transporter, permease HCN55_07855 ENOG4105E98 transcriptional regulator DeoR family HCN55_07860 ENOG4105DE4 1-phosphofructokinase HCN55_07865 ENOG4105DM4 PTS System HCN55_07870 ENOG4105C3F Signal peptidase i HCN55_07880 ENOG4105C5H ABC transporter HCN55_07885 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HCN55_07910 ENOG4105BZU Histidine kinase HCN55_07920 ENOG4107ZYR domain protein HCN55_07930 ENOG4105CN5 Metallo-Beta-Lactamase HCN55_07940 ENOG4108X4Q Hydrolase HCN55_07945 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HCN55_07965 ENOG4105CPP Dehydrogenase, E1 component HCN55_07970 ENOG4105C7S Dehydrogenase HCN55_07975 ENOG4107QN2 dihydrolipoyl dehydrogenase HCN55_07990 ENOG4105CXN decarboxylase HCN55_07995 ENOG4105WBI UPF0223 protein HCN55_08010 ENOG4105ECY inositol monophosphatase HCN55_08020 ENOG4105JQZ Methyltransferase HCN55_08060 ENOG4105CI3 gtp-binding protein typa HCN55_08065 ENOG4105QA2 HCN55_08080 ENOG4108IAB Phoh family HCN55_08090 ENOG4105CSV Glutaminase HCN55_08095 ENOG4105ZPI UPF0358 protein HCN55_08100 ENOG4105CNI cell division protein FtsW HCN55_08105 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HCN55_08115 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HCN55_08125 ENOG4105BZ9 Cytochrome C oxidase, subunit I HCN55_08130 ENOG4105CCU oxidase (Subunit III) HCN55_08135 ENOG41064X9 cytochrome C oxidase subunit IV HCN55_08150 ENOG41080XQ Signal transduction protein with cbs domains HCN55_08155 ENOG4106UY4 Inherit from COG: Scp-like extracellular HCN55_08175 ENOG4105WUC UPF0298 protein HCN55_08180 ENOG4106H78 methyltransferase HCN55_08185 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HCN55_08190 ENOG4105H20 Sporulation integral membrane protein YlbJ HCN55_08195 ENOG4105D78 K07001 NTE family protein HCN55_08200 ENOG41063PX domain protein HCN55_08205 ENOG4105CDE UPF0348 protein HCN55_08215 ENOG4105KNH Nucleic acid-binding protein HCN55_08245 ENOG4108V6E Cell division protein mraZ HCN55_08250 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HCN55_08260 ENOG4105CJN penicillin-binding protein HCN55_08265 ENOG4105CJN penicillin-binding protein HCN55_08270 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HCN55_08275 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HCN55_08280 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HCN55_08285 ENOG4105CNI cell division protein FtsW HCN55_08290 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HCN55_08295 ENOG4105D4A Cell wall formation (By similarity) HCN55_08300 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HCN55_08305 ENOG4108R2U division initiation protein HCN55_08315 ENOG4105K67 small basic protein HCN55_08320 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HCN55_08325 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HCN55_08335 ENOG4105FFI sigma-e processing peptidase spoiiga HCN55_08340 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCN55_08350 ENOG4105DKW ABC transporter HCN55_08360 ENOG4105WR5 sporulation protein, YlmC YmxH family HCN55_08365 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HCN55_08370 ENOG4105DFA alanine racemase domain protein HCN55_08375 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HCN55_08380 ENOG41067XK integral membrane protein HCN55_08385 ENOG4105DBK s4 domain protein HCN55_08395 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HCN55_08405 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HCN55_08410 ENOG4105C34 Pseudouridine synthase HCN55_08415 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HCN55_08425 ENOG4105CXT aspartate transcarbamylase HCN55_08435 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HCN55_08440 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HCN55_08445 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HCN55_08450 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HCN55_08455 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HCN55_08460 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HCN55_08465 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HCN55_08475 ENOG4107S4M Sulfate adenylate transferase HCN55_08480 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HCN55_08485 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HCN55_08490 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HCN55_08495 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HCN55_08510 ENOG4105DSJ YicC domain protein HCN55_08515 ENOG4105KC4 UPF0296 protein HCN55_08520 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HCN55_08530 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HCN55_08535 ENOG4105C25 Primosomal protein n' HCN55_08540 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HCN55_08545 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HCN55_08550 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HCN55_08555 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HCN55_08560 ENOG4108ZF3 Phosphatase HCN55_08565 ENOG4105D9P serine threonine protein kinase HCN55_08570 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HCN55_08575 ENOG4105DJV ribulose-phosphate 3-epimerase HCN55_08580 ENOG4105FJ0 thiamine HCN55_08590 ENOG4105VB9 50S ribosomal protein l28 HCN55_08595 ENOG4108ZAA Alkaline-shock protein HCN55_08600 ENOG4105DP4 dak2 domain fusion protein ylov HCN55_08610 ENOG4105EJQ L-serine dehydratase HCN55_08615 ENOG4105CB5 ATP-dependent DNA helicase recG HCN55_08620 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HCN55_08630 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HCN55_08635 ENOG4105CHR reductase HCN55_08645 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HCN55_08650 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HCN55_08655 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HCN55_08665 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HCN55_08675 ENOG4105K5M 30s ribosomal protein S16 HCN55_08680 ENOG4108BW8 UPF0109 protein HCN55_08690 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HCN55_08695 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HCN55_08700 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HCN55_08705 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HCN55_08710 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HCN55_08720 ENOG4105VM1 flagellar HCN55_08725 ENOG4105CMV Succinyl-CoA synthetase subunit beta HCN55_08730 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HCN55_08735 ENOG4105C79 DNA protecting protein DprA HCN55_08740 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HCN55_08745 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HCN55_08750 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HCN55_08755 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HCN55_08760 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HCN55_08770 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HCN55_08775 ENOG4108ZC9 flagellar basal-body rod protein flgc HCN55_08780 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HCN55_08785 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HCN55_08790 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HCN55_08805 ENOG4106YF4 Flagellar biosynthesis chaperone HCN55_08815 ENOG410696Y Flagellar hook-length control protein HCN55_08820 ENOG410822I Flagellar hook capping protein HCN55_08825 ENOG4108JQA flagellar HCN55_08830 ENOG41068WV flagellar FlbD family protein HCN55_08840 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HCN55_08845 ENOG4105DD5 Flagellar motor switch protein HCN55_08850 ENOG4107YTP response regulator receiver protein HCN55_08860 ENOG4105CN7 Flagellar biosynthetic protein FliP HCN55_08865 ENOG4105VS8 Flagellar biosynthetic protein fliq HCN55_08870 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HCN55_08875 ENOG4105D00 flagellar biosynthetic protein flhB HCN55_08880 ENOG4105D7B Flagellar biosynthesis protein flha HCN55_08885 ENOG4105FZW flagellar biosynthesis regulator FlhF HCN55_08895 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HCN55_08900 ENOG4105CBS Chea signal transduction histidine kinase HCN55_08905 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HCN55_08920 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCN55_08930 ENOG4105CE9 30S ribosomal protein S2 HCN55_08935 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HCN55_08945 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HCN55_08950 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HCN55_08955 ENOG4105KNE Phosphatidate cytidylyltransferase HCN55_08965 ENOG4105DZP Membrane-associated zinc metalloprotease HCN55_08970 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HCN55_08975 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HCN55_08980 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HCN55_08985 ENOG4105CHV Transcription elongation factor NusA HCN55_08990 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HCN55_08995 ENOG4105VHM ribosomal protein HCN55_09000 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HCN55_09005 ENOG4105W7A Protein of unknown function (DUF503) HCN55_09010 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HCN55_09015 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HCN55_09020 ENOG4105DTN riboflavin biosynthesis protein ribF HCN55_09025 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HCN55_09030 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HCN55_09040 ENOG4105C1V Peptidase, M16 HCN55_09050 ENOG4105E35 Dipicolinate synthase subunit A HCN55_09055 ENOG4108S0H Dipicolinic acid synthetase, b subunit HCN55_09060 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HCN55_09070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HCN55_09080 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HCN55_09090 ENOG4105CNU cell division protein FtsK HCN55_09095 ENOG4105FDP GntR family transcriptional regulator HCN55_09115 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HCN55_09120 ENOG4105XZV Protein of unknown function (DUF3243) HCN55_09135 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HCN55_09140 ENOG4105CEV competence damage-inducible protein HCN55_09150 ENOG4108A04 Beta-lactamase HCN55_09155 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HCN55_09160 ENOG4105D48 metallophosphoesterase HCN55_09165 ENOG4105MCT stage V sporulation protein S HCN55_09175 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HCN55_09180 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HCN55_09195 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HCN55_09200 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HCN55_09210 ENOG4105IIP Membrane HCN55_09215 ENOG4105W1N transcriptional regulator HCN55_09220 ENOG4108151 Beta-lactamase domain protein HCN55_09230 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HCN55_09240 ENOG4107QKG PfaD family HCN55_09245 ENOG41062T2 Acyl carrier protein HCN55_09250 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase HCN55_09255 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HCN55_09260 ENOG4108MGH Enoyl-CoA hydratase HCN55_09265 ENOG4108KQ6 Enoyl-CoA hydratase HCN55_09270 ENOG4105C0W non-ribosomal peptide synthetase HCN55_09275 ENOG4107SQU synthase HCN55_09285 ENOG4105C0W non-ribosomal peptide synthetase HCN55_09295 ENOG4106A3M Cytochrome p-450 HCN55_09310 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCN55_09315 ENOG4105K7W phage-related replication protein HCN55_09320 ENOG4108X3M OsmC Ohr family protein HCN55_09325 ENOG410814C multidrug resistance protein HCN55_09345 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HCN55_09350 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HCN55_09365 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HCN55_09370 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HCN55_09375 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HCN55_09380 ENOG4105U6W MutT NUDIX family protein HCN55_09385 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HCN55_09390 ENOG4106F1P AAA ATPase, central domain protein HCN55_09395 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HCN55_09400 ENOG4105CXI aluminum resistance protein HCN55_09405 ENOG4105KV4 Transcriptional regulator HCN55_09410 ENOG4105C5F glutamine synthetase HCN55_09415 ENOG41079P0 HCN55_09435 ENOG4107AUC HCN55_09470 ENOG410907G HCN55_09475 ENOG4105CT4 transporter HCN55_09480 ENOG4105DSG hydrolase family 43 HCN55_09485 ENOG4105E2R ROK family HCN55_09490 ENOG4105C93 Xylose Isomerase HCN55_09495 ENOG4105CMG Carbohydrate kinase HCN55_09505 ENOG4107Y9E nuclease HCN55_09510 ENOG4105C54 Major Facilitator superfamily HCN55_09515 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HCN55_09525 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HCN55_09540 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HCN55_09595 ENOG4108Q8B Spore germination protein HCN55_09600 ENOG4108NHD germination protein HCN55_09615 ENOG4105FVX HCN55_09625 ENOG4105K7W phage-related replication protein HCN55_09635 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HCN55_09640 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HCN55_09650 ENOG4108SVB resolvase HCN55_09655 ENOG4105VPS UPF0291 protein HCN55_09660 ENOG4105CV1 Transketolase (EC 2.2.1.1) HCN55_09680 ENOG4107QIV Cytochrome c biogenesis protein HCN55_09705 ENOG4107DZX Small, acid-soluble spore protein P HCN55_09715 ENOG4108I0Z Aconitate hydratase HCN55_09720 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HCN55_09735 ENOG41067CD Small, acid-soluble spore protein Tlp HCN55_09745 ENOG4105MI2 HCN55_09750 ENOG4105W8X HesB YadR YfhF-family protein HCN55_09755 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HCN55_09760 ENOG4105K4P CoA-binding domain protein HCN55_09765 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HCN55_09795 ENOG4108MYR Secreted protein HCN55_09800 ENOG4107SYN Glycosyl hydrolases family 43 HCN55_09810 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HCN55_09815 ENOG4107T5V SNARE associated Golgi HCN55_09825 ENOG4107QX3 carboxylase HCN55_09830 ENOG4105E39 Enoyl-CoA hydratase HCN55_09835 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HCN55_09840 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HCN55_09845 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HCN55_09850 ENOG4105CEY Amp-dependent synthetase and ligase HCN55_09855 ENOG4105C1G acyl-Coa dehydrogenase HCN55_09870 ENOG4105F32 YngK protein HCN55_09875 ENOG4106U2H Protein of unknown function (DUF1360) HCN55_09885 ENOG4105CEY Amp-dependent synthetase and ligase HCN55_09890 ENOG4105C0W non-ribosomal peptide synthetase HCN55_09900 ENOG4105C0W non-ribosomal peptide synthetase HCN55_09905 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HCN55_09910 ENOG4108N2V aldose 1-epimerase HCN55_09915 ENOG4107QJQ Mate efflux family protein HCN55_09940 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HCN55_09945 ENOG4105SKE transcriptional Regulator LysR family HCN55_09950 ENOG4105CB2 alcohol dehydrogenase HCN55_09955 ENOG4105BZ8 glutamate synthase HCN55_09960 ENOG4105CBC glutamate synthase HCN55_09965 ENOG4105C5Q Transcriptional regulator HCN55_09970 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HCN55_09975 ENOG4105II7 pyrroline-5-carboxylate reductase HCN55_09995 ENOG4108UB7 HCN55_10000 ENOG41068WN HCN55_10005 ENOG4105IE8 Alpha-ketoglutarate permease HCN55_10010 ENOG4107U6E carbohydrate kinase FGGY HCN55_10015 ENOG4108M3J Dehydrogenase HCN55_10020 ENOG4108J2R molybdopterin oxidoreductase HCN55_10050 ENOG4105EC8 Methyl-accepting chemotaxis HCN55_10060 ENOG4108YQE rare lipoprotein a HCN55_10065 ENOG4105XPP Protein of unknown function (DUF1275) HCN55_10070 ENOG4108NR7 pectate lyase HCN55_10075 ENOG4108RAV Conserved protein HCN55_10085 ENOG4105F0F Oxalate decarboxylase HCN55_10100 ENOG4105EPI acetyltransferase, (GNAT) family HCN55_10120 ENOG41073R8 VanW family HCN55_10130 ENOG4105VMP Transcriptional regulator HCN55_10135 ENOG4105NX3 Membrane HCN55_10145 ENOG4108Q5Y Membrane HCN55_10155 ENOG4108V4B ThiJ pfpI HCN55_10160 ENOG4108J4B Beta-lactamase HCN55_10185 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HCN55_10190 ENOG4107T94 Endo-14-beta-xylanase HCN55_10195 ENOG4105YB8 TM2 domain containing protein HCN55_10200 ENOG4108IMY Transcriptional regulator HCN55_10215 ENOG4108RAV Conserved protein HCN55_10220 ENOG41079CX HCN55_10250 ENOG410780I phosphoprotein phosphatase activity HCN55_10275 ENOG4105DB4 HCN55_10295 ENOG4106ANW SMI1_KNR4 HCN55_10300 ENOG4106BHF HCN55_10320 ENOG4108Z7R Chaperone CsaA HCN55_10325 ENOG4105FTV AraC Family Transcriptional Regulator HCN55_10330 ENOG4108HJF gCN5-related N-acetyltransferase HCN55_10340 ENOG4108W8B Beta-lactamase domain protein HCN55_10350 ENOG4105D29 Helix-turn-helix type 11 domain protein HCN55_10360 ENOG4105KTU Transcriptional regulator, arsr family HCN55_10370 ENOG4108SJC Membrane HCN55_10390 ENOG4105ECK Fatty Acid Desaturase HCN55_10395 ENOG4108ZGX Histidine kinase HCN55_10400 ENOG4108S01 response regulator HCN55_10405 ENOG41069ER domain protein HCN55_10410 ENOG4105C9U ATP-dependent DNA helicase RecQ HCN55_10420 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HCN55_10425 ENOG4105SCY DNAK suppressor HCN55_10465 ENOG4105C26 Dehydrogenase HCN55_10470 ENOG4105EWU Squalene--hopene cyclase HCN55_10475 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HCN55_10480 ENOG4105C8J )-transporter HCN55_10485 ENOG4105C09 Bile acid HCN55_10490 ENOG4105C7S Dehydrogenase HCN55_10500 ENOG4107T89 von Willebrand factor, type A HCN55_10505 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HCN55_10515 ENOG4105K4H Nlp p60 protein HCN55_10520 ENOG41087PP glycosyltransferase MGT family HCN55_10530 ENOG4107QMU Mate efflux family protein HCN55_10535 ENOG4106SCS STAS domain HCN55_10555 ENOG4105FR1 rard protein HCN55_10570 ENOG4105C6Z Gluconate HCN55_10575 ENOG41090U3 tautomerase HCN55_10590 ENOG4105FBA Phospholipase Carboxylesterase HCN55_10605 ENOG4105E1V na solute symporter HCN55_10625 ENOG4108VXD carboxy-peptidase HCN55_10630 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HCN55_10640 ENOG4106Z5R HCN55_10645 ENOG410841Q phosphoesterase PA-phosphatase related protein HCN55_10675 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HCN55_10680 ENOG4108TSC N-acetyltransferase HCN55_10685 ENOG4107S4Y M20 DapE family protein YgeY HCN55_10700 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HCN55_10740 ENOG4107T32 3-phytase (EC 3.1.3.8) HCN55_10745 ENOG4105C5E polysaccharide biosynthesis protein HCN55_10755 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HCN55_10845 ENOG4105FTQ Dna gyrase HCN55_10850 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HCN55_10855 ENOG4106ITI Glutaredoxin HCN55_10875 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HCN55_10880 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HCN55_10885 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HCN55_10975 ENOG4105DVF Cytosine-specific methyltransferase HCN55_10985 ENOG4106210 phosphatase activity HCN55_11020 ENOG4106J9J DNA polymerase HCN55_11030 ENOG4106IVX HCN55_11035 ENOG4106PTB DnaB-like helicase C terminal domain HCN55_11045 ENOG41088HM HCN55_11050 ENOG4106YR8 HCN55_11080 ENOG4105K7W phage-related replication protein HCN55_11095 ENOG4108RAV Conserved protein HCN55_11100 ENOG4108J9Q DNA ligase HCN55_11155 ENOG4105GJD protein, conserved in bacteria HCN55_11185 ENOG4108ZUE Phage regulatory protein rha HCN55_11280 ENOG4107D0N HCN55_11295 ENOG4106HHG HCN55_11330 ENOG4106J6E HCN55_11335 ENOG4107NTZ HCN55_11340 ENOG41063R6 HCN55_11350 ENOG4108NE4 HCN55_11375 ENOG41067QW Transcriptional regulator HCN55_11385 ENOG4105ZUG HCN55_11390 ENOG4105K70 DNA-binding protein HCN55_11405 ENOG4106QVS HCN55_11500 ENOG41068G1 HCN55_11555 ENOG4105E4C Lytic transglycosylase catalytic HCN55_11575 ENOG4108HQ0 Exopolysaccharide biosynthesis protein HCN55_11580 ENOG4105MYH HCN55_11590 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HCN55_11610 ENOG4107R0E Glycosyl transferase, family 2 HCN55_11635 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HCN55_11665 ENOG4105UA4 acetyltransferase HCN55_11675 ENOG41090AA HCN55_11680 ENOG4106BHF HCN55_11700 ENOG4107Y9E nuclease HCN55_11710 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HCN55_11725 ENOG4106RPI HCN55_11740 ENOG4105C5E polysaccharide biosynthesis protein HCN55_11745 ENOG4105E0X reductase HCN55_11750 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HCN55_11770 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HCN55_11775 ENOG41090WU lipolytic protein G-D-S-L family HCN55_11780 ENOG4108KF3 Electron transport protein SCO1 SenC HCN55_11790 ENOG4105C7B Threonine dehydratase HCN55_11800 ENOG4108UT2 hemolysin iii HCN55_11810 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HCN55_11815 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HCN55_11830 ENOG4107YX5 Pfam:DUF548 HCN55_11835 ENOG4108Y6J UPF0403 protein HCN55_11840 ENOG4105C01 Dihydroxy-acid dehydratase HCN55_11855 ENOG4108V06 Glutathione peroxidase HCN55_11860 ENOG4105CVG Homoserine O-transsuccinylase HCN55_11905 ENOG41081VK Ribonuclease HCN55_11930 ENOG410890F Dynamin family HCN55_11945 ENOG41065KQ synthase HCN55_11950 ENOG4105C2W permease HCN55_11955 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HCN55_11960 ENOG4105CTD carboxy-peptidase HCN55_11965 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HCN55_11970 ENOG4108UHU Aldolase HCN55_11975 ENOG4105D7K pfkb domain protein HCN55_11980 ENOG4108M60 Transcriptional regulator HCN55_11990 ENOG4105CHR reductase HCN55_11995 ENOG4105DVT helicase HCN55_12010 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HCN55_12025 ENOG4108UKS UPF0398 protein HCN55_12040 ENOG4107X2U Inherit from COG: Exonuclease-like protein HCN55_12045 ENOG4108I5C dEAD DEAH box helicase HCN55_12095 ENOG4105BZ4 penicillin-binding protein HCN55_12105 ENOG4105CSM endonuclease III HCN55_12115 ENOG4105C5S asparaginyl-tRNA synthetase HCN55_12120 ENOG4105CHM Aminotransferase HCN55_12130 ENOG4105YAC HCN55_12135 ENOG4105DVT helicase HCN55_12140 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HCN55_12145 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HCN55_12150 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HCN55_12155 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HCN55_12160 ENOG4105DJ0 Poly(A) Polymerase HCN55_12165 ENOG4105CPK Glycosyl transferase (Group 1 HCN55_12170 ENOG4105FJR Lmbe family HCN55_12175 ENOG4108Z5K methylglyoxal synthase HCN55_12180 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HCN55_12185 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HCN55_12190 ENOG4108JYZ YitT family HCN55_12210 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HCN55_12230 ENOG41068YB TPR repeat-containing protein HCN55_12235 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HCN55_12245 ENOG4105CIH Imidazole acetol-phosphate transaminase HCN55_12255 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HCN55_12260 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HCN55_12270 ENOG4108I0Q anthranilate phosphoribosyltransferase HCN55_12275 ENOG4105CRQ synthase (Component I) HCN55_12280 ENOG4105KHN chorismate mutase HCN55_12285 ENOG4105D49 3-dehydroquinate synthase HCN55_12290 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HCN55_12295 ENOG4105BZU Histidine kinase HCN55_12300 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HCN55_12305 ENOG4105EAH synthase HCN55_12310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCN55_12315 ENOG4105XXQ heptaprenyl diphosphate synthase component I HCN55_12325 ENOG4105EUJ GTP cyclohydrolase i HCN55_12330 ENOG4105K70 DNA-binding protein HCN55_12335 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HCN55_12350 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HCN55_12355 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HCN55_12360 ENOG41065D1 HCN55_12365 ENOG4105S2F HCN55_12380 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HCN55_12385 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HCN55_12390 ENOG4105CAT Cytidine monophosphate kinase HCN55_12405 ENOG4105MSI germination protein ypeb HCN55_12415 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HCN55_12420 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HCN55_12435 ENOG4107RGJ metallophosphoesterase HCN55_12450 ENOG4105I7S Abortive infection protein HCN55_12455 ENOG4105C9U ATP-dependent DNA helicase RecQ HCN55_12460 ENOG4105T7X HCN55_12470 ENOG4108SAX Membrane HCN55_12475 ENOG4108JQ1 Dehydrogenase HCN55_12480 ENOG4105FF2 Type I DHQase HCN55_12495 ENOG4105BZU Histidine kinase HCN55_12500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCN55_12505 ENOG4105CRE cytochrome C HCN55_12510 ENOG4107TWT Cytochrome c biogenesis protein HCN55_12520 ENOG4105FE9 pseudouridine synthase HCN55_12530 ENOG4108JIC nucleoside recognition domain protein HCN55_12535 ENOG4105DZ1 carboxypeptidase HCN55_12545 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HCN55_12550 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HCN55_12565 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HCN55_12570 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HCN55_12575 ENOG4108R6K riboflavin synthase, subunit alpha HCN55_12580 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HCN55_12590 ENOG4105C3F Signal peptidase i HCN55_12600 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) HCN55_12615 ENOG4107ZE5 PPIases accelerate the folding of proteins HCN55_12620 ENOG4105PTM secreted protein HCN55_12625 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HCN55_12635 ENOG4105G6R Stage v sporulation protein ae HCN55_12645 ENOG4105CZ3 stage V sporulation protein ad HCN55_12650 ENOG41090VF Stage v sporulation protein ac HCN55_12665 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCN55_12670 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HCN55_12675 ENOG41082AN stage II sporulation protein HCN55_12680 ENOG4105DZ1 carboxypeptidase HCN55_12685 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HCN55_12690 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HCN55_12695 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HCN55_12705 ENOG4105I3K Ferric uptake regulator, Fur family HCN55_12710 ENOG4105MZ9 stage II sporulation protein m HCN55_12725 ENOG4105DFD Na H antiporter HCN55_12730 ENOG4108IJ0 Aspartate ammonia-lyase HCN55_12735 ENOG4105HDK L-asparaginase HCN55_12740 ENOG4108IMY Transcriptional regulator HCN55_12750 ENOG4108YZ4 nudix hydrolase HCN55_12760 ENOG4105CPC Aldo Keto reductase HCN55_12780 ENOG4106HZJ HCN55_12785 ENOG4105RHY Pfam:UPF0157 HCN55_12790 ENOG4105KAC Antibiotic biosynthesis monooxygenase HCN55_12795 ENOG4108XET gCN5-related N-acetyltransferase HCN55_12805 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HCN55_12815 ENOG4105E5W Transporter HCN55_12825 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HCN55_12840 ENOG4108IXY short-chain dehydrogenase reductase HCN55_12845 ENOG41069FQ Metallo-beta-lactamase superfamily HCN55_12850 ENOG4105II7 pyrroline-5-carboxylate reductase HCN55_12860 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HCN55_12875 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HCN55_12880 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HCN55_12885 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HCN55_12890 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HCN55_12900 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HCN55_12905 ENOG4108NA0 Uncharacterized conserved protein (COG2071) HCN55_12910 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HCN55_12915 ENOG4108HNZ carboxyl transferase HCN55_12920 ENOG4108ZVT methylmalonyl-coA epimerase HCN55_12930 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HCN55_12935 ENOG4108QEG Membrane HCN55_12940 ENOG4105CDA abc transporter atp-binding protein HCN55_12945 ENOG4105E5Q amino acid AbC transporter HCN55_12950 ENOG4108HW3 (ABC) transporter HCN55_12955 ENOG4108Y6J UPF0403 protein HCN55_12960 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HCN55_12975 ENOG4105C7S Dehydrogenase HCN55_12980 ENOG4105CPP Dehydrogenase, E1 component HCN55_12995 ENOG4105CKM Branched-chain carboxylic acid kinase HCN55_13000 ENOG4107RDP Dehydrogenase HCN55_13010 ENOG4108JUB Transcriptional regulator HCN55_13015 ENOG4106CCJ Protein of unknown function (DUF2627) HCN55_13020 ENOG4105CR4 methylisocitrate lyase HCN55_13025 ENOG4105DXD 2-methylcitrate dehydratase HCN55_13035 ENOG4105C1G acyl-Coa dehydrogenase HCN55_13040 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HCN55_13050 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HCN55_13055 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HCN55_13070 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HCN55_13075 ENOG4107QQR Sporulation HCN55_13080 ENOG4105S1Z Stage IV sporulation protein B HCN55_13085 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HCN55_13090 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HCN55_13095 ENOG4105DX0 Hemolysin A HCN55_13105 ENOG4105CTB Polyprenyl synthetase HCN55_13110 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HCN55_13115 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HCN55_13120 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HCN55_13125 ENOG4105M7K Involved in the transcription termination process (By similarity) HCN55_13130 ENOG4108ZSR alkaline shock protein HCN55_13135 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HCN55_13155 ENOG410644B Stage III sporulation protein af HCN55_13165 ENOG4105KQ4 Stage iii sporulation protein ad HCN55_13170 ENOG4108CQH stage III sporulation protein AC HCN55_13175 ENOG4105KR5 Stage iii sporulation protein HCN55_13180 ENOG4105CD2 stage iii sporulation protein aa HCN55_13190 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HCN55_13195 ENOG4105DC7 peptidase M24 HCN55_13200 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HCN55_13210 ENOG4105CBJ Metal-dependent enzyme HCN55_13225 ENOG4105KST dependent repressor HCN55_13230 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HCN55_13235 ENOG4105WZW rhodanese family HCN55_13240 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HCN55_13245 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HCN55_13250 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HCN55_13255 ENOG4105C0D helicase HCN55_13270 ENOG4108IMY Transcriptional regulator HCN55_13280 ENOG4105VFR signal peptidase HCN55_13340 ENOG4105C37 (CBS) domain HCN55_13365 ENOG4105C5X domain protein HCN55_13390 ENOG4105E0M Sulfatase HCN55_13405 ENOG4107ZXI Rhomboid family HCN55_13415 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HCN55_13440 ENOG41068DG YceG-like family HCN55_13445 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HCN55_13450 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HCN55_13455 ENOG4105E2Z phosphate ABC transporter (Permease HCN55_13460 ENOG4105C8U phosphate abc transporter HCN55_13465 ENOG4105CVA phosphate HCN55_13470 ENOG4107RF6 penicillin-binding protein HCN55_13480 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HCN55_13485 ENOG4105SXS Protein of unknown function (DUF456) HCN55_13505 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HCN55_13510 ENOG41063Y9 HCN55_13515 ENOG4108U5J '-nucleotidase HCN55_13520 ENOG4105N80 Ferric uptake regulator, Fur family HCN55_13525 ENOG4108JYZ YitT family HCN55_13530 ENOG41069ZM Protein of unknown function (DUF2624) HCN55_13535 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HCN55_13550 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HCN55_13555 ENOG4105EGD dinuclear metal center protein, YbgI family HCN55_13570 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCN55_13575 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HCN55_13580 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 HCN55_13585 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HCN55_13595 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HCN55_13600 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HCN55_13605 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HCN55_13615 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HCN55_13620 ENOG4105KG3 cytidine deaminase HCN55_13625 ENOG4107YR5 Diacylglycerol kinase HCN55_13630 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HCN55_13635 ENOG4105CTJ Metal Dependent Phosphohydrolase HCN55_13640 ENOG4105C9A Phoh family HCN55_13645 ENOG4105EI1 sporulation protein yqfd HCN55_13650 ENOG41068P3 sporulation protein YqfC HCN55_13660 ENOG4105DI5 UPF0365 protein HCN55_13665 ENOG4105F7J membrane-bound serine protease HCN55_13670 ENOG4105KTH gatB Yqey HCN55_13685 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HCN55_13690 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HCN55_13695 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HCN55_13705 ENOG4105CFG Acts as a chaperone (By similarity) HCN55_13710 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HCN55_13715 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HCN55_13720 ENOG4105CSA Coproporphyrinogen iii oxidase HCN55_13725 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HCN55_13735 ENOG4108ZRV stage ii sporulation protein p HCN55_13740 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HCN55_13745 ENOG41082YS Binds directly to 16S ribosomal RNA HCN55_13750 ENOG4105TQK DNA polymerase iii, delta' subunit HCN55_13765 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HCN55_13770 ENOG4108UK2 deaminase HCN55_13775 ENOG4105KQC Competence protein HCN55_13785 ENOG4108D32 Methyltransferase HCN55_13795 ENOG4108WF2 Metal Dependent Phosphohydrolase HCN55_13800 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HCN55_13805 ENOG410812S Rna-binding protein HCN55_13810 ENOG4105E2X shikimate dehydrogenase HCN55_13815 ENOG4105CQW ribosome biogenesis GTPase YqeH HCN55_13820 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HCN55_13835 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HCN55_13840 ENOG41080BT SNARE associated Golgi HCN55_13855 ENOG4105WFK nuclease HCN55_13865 ENOG4107Y5K Resolvase HCN55_13870 ENOG4108UXE Protein tyrosine phosphatase HCN55_13875 ENOG4105D6J arsenicaL-resistance protein HCN55_13880 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HCN55_13885 ENOG41085FC arsR family transcriptional regulator HCN55_13915 ENOG41064HX Suppressor of fused protein (SUFU) HCN55_13935 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HCN55_13970 ENOG410906S phage-like element pbsx protein xkdt HCN55_13975 ENOG41066EA baseplate J family protein HCN55_13980 ENOG4105MFU Protein of unknown function (DUF2634) HCN55_13990 ENOG4105X7F HCN55_13995 ENOG4108WZM domain protein HCN55_14000 ENOG4108FKH Transglycosylase SLT domain HCN55_14010 ENOG4105MTC XkdN-like protein HCN55_14025 ENOG4105FR7 XkdM protein, phage-like element PBSX HCN55_14030 ENOG4105PQS phage protein HCN55_14045 ENOG41060SN HCN55_14080 ENOG4106CGH Phage Mu protein F like protein HCN55_14085 ENOG4108MDF Phage Portal Protein HCN55_14090 ENOG4105IG6 Phage terminase, large subunit HCN55_14110 ENOG4106129 HCN55_14120 ENOG4105QBX endodeoxyribonuclease RusA HCN55_14140 ENOG4108PNI recT protein HCN55_14145 ENOG4108NF7 phage-type endonuclease HCN55_14175 ENOG4106A7E Transcriptional regulator HCN55_14180 ENOG41067QW Transcriptional regulator HCN55_14190 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HCN55_14225 ENOG4108SWU Histidine kinase HCN55_14230 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCN55_14235 ENOG4105DHF Membrane HCN55_14245 ENOG4108UYN gCN5-related N-acetyltransferase HCN55_14250 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HCN55_14255 ENOG41068VA HCN55_14260 ENOG41087NI Sulfite exporter TauE/SafE HCN55_14265 ENOG4105VFE sira family HCN55_14270 ENOG4107TPS domain protein HCN55_14280 ENOG4105VFE sira family HCN55_14290 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HCN55_14295 ENOG4105XTG Pfam:DUF156 HCN55_14300 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein HCN55_14310 ENOG41090E6 transcriptional regulator MERR family HCN55_14325 ENOG4105C37 (CBS) domain HCN55_14340 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HCN55_14345 ENOG4105H3G oxidoreductase HCN55_14350 ENOG4105PGM cation diffusion facilitator family transporter HCN55_14355 ENOG41090U3 tautomerase HCN55_14375 ENOG4105KMT branched-chain amino acid HCN55_14380 ENOG4108UMN azlc family HCN55_14385 ENOG4108ZRZ Transcriptional regulator (AsnC family) HCN55_14390 ENOG41067XF inhibitor HCN55_14410 ENOG41064BW Protein of unknown function (DUF2568) HCN55_14425 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HCN55_14430 ENOG4105EA8 2-Nitropropane dioxygenase HCN55_14435 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HCN55_14455 ENOG4108MEK Metal-binding protein YodA HCN55_14460 ENOG410904A RNA polymerase HCN55_14465 ENOG4105CPC Aldo Keto reductase HCN55_14475 ENOG4108KAM Transcriptional regulator HCN55_14480 ENOG4105C7F AcnD-accessory protein PrpF HCN55_14485 ENOG41083Q9 chitosanase HCN55_14490 ENOG4105X5K response regulator receiver protein HCN55_14495 ENOG4108VQT Alpha beta hydrolase fold protein HCN55_14500 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HCN55_14505 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HCN55_14515 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase HCN55_14525 ENOG4105PGS Spore coat protein HCN55_14530 ENOG4105E2A Dehydrogenase HCN55_14545 ENOG4105VUF Transcriptional regulator HCN55_14555 ENOG4105DQ4 alcohol dehydrogenase HCN55_14560 ENOG4108Z0Z intracellular protease Pfpi family HCN55_14565 ENOG4108HKT sucrose-6-phosphate hydrolase HCN55_14570 ENOG4105F3R pts system mannose fructose sorbose family iid HCN55_14575 ENOG4105ETZ PTS System HCN55_14580 ENOG4108IQ3 PTS system HCN55_14585 ENOG4105YHU PTS system HCN55_14590 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HCN55_14600 ENOG4105C85 amino acid HCN55_14605 ENOG4105N14 lysine exporter protein LysE YggA HCN55_14610 ENOG4108NGU Transcriptional regulator HCN55_14615 ENOG4105JVQ RNA Polymerase HCN55_14620 ENOG4108P49 AntiSigma factor HCN55_14625 ENOG4105EXC Acyl-transferase HCN55_14630 ENOG4105WDR HCN55_14635 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HCN55_14640 ENOG41082JN Transcriptional regulator HCN55_14660 ENOG4105TMB Formate nitrite transporter HCN55_14665 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HCN55_14670 ENOG4108JB9 formate dehydrogenase HCN55_14685 ENOG4105C28 cystathionine HCN55_14700 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HCN55_14715 ENOG4107XRG penicillin-binding protein HCN55_14720 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HCN55_14725 ENOG4105DBI uridine monophosphokinase HCN55_14730 ENOG4105CFP Peptidase U32 HCN55_14735 ENOG4105XYU peptidase (U32 family) HCN55_14745 ENOG4105HHA aminodeoxychorismate lyase HCN55_14750 ENOG4105VPH UPF0473 protein HCN55_14755 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HCN55_14760 ENOG4105VBH UPF0297 protein HCN55_14765 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HCN55_14770 ENOG4105C02 permease HCN55_14775 ENOG4105CDA abc transporter atp-binding protein HCN55_14780 ENOG4105CT1 (ABC) transporter HCN55_14785 ENOG4105EAD ABC transporter HCN55_14790 ENOG4105DRP amino acid AbC transporter HCN55_14800 ENOG41060CR HCN55_14810 ENOG4105C7H Helicase, RecD TraA family HCN55_14820 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HCN55_14825 ENOG4105C3J Cysteine desulfurase HCN55_14835 ENOG4105D1H recombination factor protein RarA HCN55_14840 ENOG4105CUZ uba thif-type nad fad binding protein HCN55_14850 ENOG4105C9M aspartyl-trna synthetase HCN55_14855 ENOG4105CUT histidyl-tRNA synthetase HCN55_14865 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HCN55_14875 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HCN55_14880 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HCN55_14885 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HCN55_14890 ENOG41067VP Protein of unknown function (DUF1049) HCN55_14895 ENOG4105NCW Trka-c domain protein HCN55_14900 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HCN55_14910 ENOG4105CKP Polysaccharide Biosynthesis Protein HCN55_14915 ENOG4108QG2 Membrane HCN55_14920 ENOG4105NAP HCN55_14925 ENOG4105VIE preprotein translocase, subunit YajC HCN55_14930 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HCN55_14935 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HCN55_14940 ENOG41061AI Protein of unknown function (DUF2905) HCN55_14945 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HCN55_14950 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HCN55_14960 ENOG4105IE8 Alpha-ketoglutarate permease HCN55_14965 ENOG4105CK5 oxidoreductase HCN55_14990 ENOG4105BZG amino acid carrier protein HCN55_14995 ENOG4105CDY transcriptional regulatory protein HCN55_15005 ENOG4106678 morphogenetic protein associated with SpoVID HCN55_15010 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HCN55_15015 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HCN55_15020 ENOG4108IYU L-aspartate oxidase HCN55_15035 ENOG4105CQC Prephenate dehydratase HCN55_15040 ENOG41090I5 UPF0735 ACT domain-containing protein HCN55_15045 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HCN55_15060 ENOG4105K46 50S ribosomal protein l27 HCN55_15065 ENOG4105X36 (ribosomal) protein HCN55_15070 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HCN55_15085 ENOG4107QMS site-determining protein HCN55_15090 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HCN55_15095 ENOG4105YHC Rod shape-determining protein MreD HCN55_15105 ENOG4105DFF Rod shape-determining protein mreb HCN55_15110 ENOG4105W5Q DNA repair protein (RadC HCN55_15115 ENOG4108Z03 MAF-like protein HCN55_15125 ENOG4106A3R peptidase HCN55_15130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HCN55_15135 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HCN55_15145 ENOG4106AR7 Spore coat protein HCN55_15150 ENOG41068KH stage VI sporulation protein D HCN55_15155 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HCN55_15160 ENOG4105D52 delta-aminolevulinic acid dehydratase HCN55_15170 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HCN55_15180 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HCN55_15190 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HCN55_15195 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HCN55_15200 ENOG4108IUQ atp-dependent protease HCN55_15205 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HCN55_15210 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HCN55_15220 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HCN55_15225 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HCN55_15230 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HCN55_15235 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HCN55_15240 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HCN55_15245 ENOG4108ZP8 Acetolactate synthase small subunit HCN55_15250 ENOG4105C7K acetolactate synthase HCN55_15260 ENOG4105I4A GCN5-related N-acetyltransferase HCN55_15265 ENOG4107KM7 Heat induced stress protein YflT HCN55_15275 ENOG4105M59 Phosphodiesterase, mj0936 family HCN55_15280 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HCN55_15285 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HCN55_15290 ENOG4108XJQ germination protein HCN55_15295 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HCN55_15300 ENOG41067TZ transcriptional regulator, MarR family HCN55_15305 ENOG4105PFC Transcriptional regulator HCN55_15315 ENOG4105E33 succinate dehydrogenase HCN55_15325 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HCN55_15335 ENOG4105CFH Aspartokinase HCN55_15340 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HCN55_15345 ENOG4105K63 Thioredoxin HCN55_15350 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HCN55_15355 ENOG4105C10 Electron transfer flavoprotein HCN55_15360 ENOG4105BZJ Electron transfer flavoprotein HCN55_15365 ENOG41060WC Enoyl-CoA hydratase HCN55_15370 ENOG4107Z3H Transcriptional regulator, TetR family HCN55_15375 ENOG4105CEY Amp-dependent synthetase and ligase HCN55_15385 ENOG4105C98 muts2 protein HCN55_15390 ENOG4105DCG PHP domain protein HCN55_15405 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HCN55_15410 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HCN55_15415 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HCN55_15425 ENOG4108RWN rrna methyltransferase HCN55_15430 ENOG41067MF small acid-soluble spore protein HCN55_15440 ENOG4105CQB FAD linked oxidase domain protein HCN55_15445 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HCN55_15465 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HCN55_15470 ENOG4105DRS transport system, permease HCN55_15485 ENOG4108MDK Dehydrogenase HCN55_15495 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HCN55_15500 ENOG4105EF1 ribulokinase HCN55_15510 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HCN55_15515 ENOG4105CN9 Peptidase m42 family protein HCN55_15525 ENOG410696E Membrane HCN55_15530 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HCN55_15535 ENOG4105VJV 50s ribosomal protein L35 HCN55_15540 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HCN55_15550 ENOG41067MG lrgb family HCN55_15560 ENOG4105DY9 regulatoR HCN55_15565 ENOG4108HRK Histidine kinase HCN55_15575 ENOG4105C22 threonyL-tRNA synthetase HCN55_15580 ENOG4108TDW sporulation protein YtxC HCN55_15600 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HCN55_15605 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HCN55_15610 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HCN55_15615 ENOG4105KVH Transcriptional regulator HCN55_15620 ENOG4105F27 Major Facilitator HCN55_15625 ENOG4105CV8 reductase HCN55_15630 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HCN55_15640 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HCN55_15645 ENOG4105C2M dna polymerase I HCN55_15650 ENOG4105BZU Histidine kinase HCN55_15655 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCN55_15660 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HCN55_15665 ENOG4108HMX isocitrate dehydrogenase (NADP) HCN55_15670 ENOG4105BZN citrate synthase HCN55_15680 ENOG4108REF Sporulation integral membrane protein ytvi HCN55_15685 ENOG4105FS0 cytoplasmic membrane protein HCN55_15690 ENOG4105CA9 Pyruvate kinase HCN55_15695 ENOG4105CTQ phosphohexokinase HCN55_15705 ENOG4108IEY Carboxyl transferase domain HCN55_15710 ENOG4105C6K Malic enzyme HCN55_15715 ENOG4105C0B DNA polymerase III (alpha subunit) HCN55_15720 ENOG4105VV2 HCN55_15730 ENOG4106EVM HCN55_15735 ENOG4105SFS phosphoesterase RecJ domain protein HCN55_15750 ENOG410635A Membrane HCN55_15755 ENOG4105CH2 amidohydrolase HCN55_15775 ENOG4105DEN Luciferase family HCN55_15780 ENOG4105CDA abc transporter atp-binding protein HCN55_15805 ENOG4108XSB acetyltransferase, (GNAT) family HCN55_15810 ENOG4108KSA LysR family transcriptional regulator HCN55_15815 ENOG4105E8R UPF0173 metal-dependent hydrolase HCN55_15830 ENOG4105CH7 arginosuccinase HCN55_15835 ENOG4105CDH Citrulline--aspartate ligase HCN55_15840 ENOG4105EPU Molybdenum cofactor synthesis domain protein HCN55_15845 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HCN55_15860 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HCN55_15865 ENOG4105KBJ sporulation protein ytfj HCN55_15875 ENOG4105VK3 rdd domain containing protein HCN55_15880 ENOG4105D07 Signal peptide peptidase, SppA HCN55_15885 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HCN55_15890 ENOG4105EFZ amidohydrolase HCN55_15895 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HCN55_15930 ENOG4105U5Y Transcriptional regulator HCN55_15940 ENOG4105BZU Histidine kinase HCN55_15950 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HCN55_15955 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HCN55_15965 ENOG4105F1V Acetoin utilization protein HCN55_15970 ENOG4105W87 Cbs domain HCN55_15975 ENOG4105DGU Histone deacetylase HCN55_15980 ENOG4105ER2 Ompa motb domain protein HCN55_15985 ENOG4107R0U MotA TolQ exbB proton channel HCN55_15990 ENOG4105ETE Transcriptional regulator (LacI family HCN55_15995 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HCN55_16015 ENOG4105DFU Cell wall formation (By similarity) HCN55_16025 ENOG4108VDD TRNA binding domain protein HCN55_16045 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HCN55_16060 ENOG4105C6K Malic enzyme HCN55_16065 ENOG4105C8F Beta-lactamase domain protein HCN55_16070 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HCN55_16080 ENOG4108V15 phosphotransferase enzyme family HCN55_16085 ENOG4108IUM Glycogen debranching enzyme HCN55_16100 ENOG4107F58 2'-5' rna ligase HCN55_16105 ENOG4105C6T cysteine synthase HCN55_16110 ENOG4107QSE Dipeptidase HCN55_16115 ENOG4105C7N Xanthine uracil vitamin C permease HCN55_16130 ENOG4105YW5 deoR family transcriptional regulator HCN55_16145 ENOG4105CBX hi0933 family HCN55_16150 ENOG4105C94 Transporter HCN55_16160 ENOG4105MU9 integral membrane protein HCN55_16165 ENOG4105DDC Oxidoreductase domain protein HCN55_16175 ENOG4105F5H Glycosyl Hydrolase Family 88 HCN55_16200 ENOG41075H3 AraC family transcriptional regulator HCN55_16210 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HCN55_16220 ENOG4106A3M Cytochrome p-450 HCN55_16225 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HCN55_16230 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HCN55_16235 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HCN55_16240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HCN55_16245 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) HCN55_16250 ENOG4105NTD Inherit from COG: Hydrolase HCN55_16280 ENOG41085GJ domain protein HCN55_16285 ENOG4105C8T Leucyl-tRNA synthetase HCN55_16295 ENOG4105BZU Histidine kinase HCN55_16300 ENOG410605W Major Facilitator HCN55_16305 ENOG4106UBQ HCN55_16315 ENOG4105C19 ABC transporter HCN55_16320 ENOG4105EWM Histidine kinase HCN55_16330 ENOG4107R34 abc transporter permease protein HCN55_16335 ENOG4105C19 ABC transporter HCN55_16350 ENOG4105DVE abc transporter atp-binding protein HCN55_16355 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HCN55_16370 ENOG4105N5T Radical SAM Protein HCN55_16385 ENOG4105E8V Alpha Beta Hydrolase Fold protein HCN55_16390 ENOG4108Z0R Transferase HCN55_16395 ENOG4105C85 amino acid HCN55_16400 ENOG4105CAQ asparagine synthetase HCN55_16410 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HCN55_16425 ENOG4105D2X ABC transporter substrate-binding protein HCN55_16435 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HCN55_16450 ENOG4108RMU ferritin dps family protein HCN55_16465 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HCN55_16470 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HCN55_16475 ENOG4108V2W Carbonate dehydratase HCN55_16500 ENOG4105CC5 ABC transporter HCN55_16505 ENOG4105CC5 ABC transporter HCN55_16510 ENOG4105DIK (ABC) transporter HCN55_16515 ENOG4105DSE periplasmic solute binding protein HCN55_16520 ENOG4105DTQ mandelate racemase muconate lactonizing HCN55_16525 ENOG4105CEY Amp-dependent synthetase and ligase HCN55_16530 ENOG4108IPT Naphthoate synthase HCN55_16535 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HCN55_16540 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HCN55_16545 ENOG4105E4F Isochorismate synthase HCN55_16565 ENOG4108IAJ Nad-dependent epimerase dehydratase HCN55_16570 ENOG4107SBE Glycosyl transferase (Group 1 HCN55_16585 ENOG4107SBE Glycosyl transferase (Group 1 HCN55_16590 ENOG4108KS4 Spore coat protein HCN55_16605 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HCN55_16615 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HCN55_16745 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HCN55_16750 ENOG4105VRR gCN5-related N-acetyltransferase HCN55_16755 ENOG4105DZ6 Band 7 protein HCN55_16765 ENOG4106DF1 HCN55_16770 ENOG4108VNY MOSC domain protein HCN55_16775 ENOG4108JB8 alcohol dehydrogenase HCN55_16785 ENOG4105TRT Transcriptional regulator HCN55_16800 ENOG4105CZN Potassium uptake protein HCN55_16805 ENOG4107I77 yiaA/B two helix domain HCN55_16810 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HCN55_16830 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HCN55_16840 ENOG4105EE0 oxidoreductase HCN55_16845 ENOG4105DKG l-rhamnose isomerase HCN55_16850 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HCN55_16855 ENOG4105DET Rhamnulokinase HCN55_16860 ENOG4105E98 transcriptional regulator DeoR family HCN55_16870 ENOG4105C8Q Methyl-accepting chemotaxis HCN55_16875 ENOG4105C8Q Methyl-accepting chemotaxis HCN55_16880 ENOG4105C8Q Methyl-accepting chemotaxis HCN55_16885 ENOG4105C8Q Methyl-accepting chemotaxis HCN55_16900 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HCN55_16915 ENOG4105C37 (CBS) domain HCN55_16930 ENOG4107PBV potassium channel HCN55_16935 ENOG4107PBV potassium channel HCN55_16950 ENOG4107QYV phosphohexose isomerase HCN55_16960 ENOG4107QW4 alcohol dehydrogenase HCN55_16965 ENOG4105WG9 Conserved Protein HCN55_16975 ENOG4105CHM Aminotransferase HCN55_16980 ENOG4108ZB6 transcriptional regulator AsnC family HCN55_16985 ENOG4108MUZ hydrolase HCN55_16995 ENOG4105C87 Aminotransferase class I and II HCN55_17000 ENOG4108HGU Histidine kinase HCN55_17005 ENOG4105Y38 Kinase-associated protein B HCN55_17025 ENOG4105BZ4 penicillin-binding protein HCN55_17030 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HCN55_17045 ENOG4108MRH transcriptional regulatory protein HCN55_17050 ENOG4105DIH basic membrane HCN55_17055 ENOG4108JQ9 ABC transporter HCN55_17060 ENOG4105UIB (ABC) transporter HCN55_17080 ENOG4105D65 subunit l HCN55_17085 ENOG4105HC0 Na H antiporter HCN55_17090 ENOG4108ZE9 Monovalent cation H antiporter subunit C HCN55_17095 ENOG4108JPZ Monovalent cation H antiporter subunit D HCN55_17100 ENOG4105SC1 monovalent cation H antiporter subunit E HCN55_17110 ENOG4105KJM monovalent cation h antiporter subunit g HCN55_17115 ENOG4105KA0 thioesterase Superfamily protein HCN55_17125 ENOG4105BZU Histidine kinase HCN55_17155 ENOG4105D58 Diguanylate phosphodiesterase HCN55_17160 ENOG4105DAP Nicotinate phosphoribosyltransferase HCN55_17185 ENOG4105C02 permease HCN55_17205 ENOG410904N short-chain dehydrogenase reductase HCN55_17240 ENOG4108K8K Transcriptional regulator HCN55_17245 ENOG4105DCF alanine dehydrogenase HCN55_17255 ENOG4105WQT MbtH domain protein HCN55_17260 ENOG4105CEY Amp-dependent synthetase and ligase HCN55_17265 ENOG4105WQI isochorismatase HCN55_17270 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HCN55_17275 ENOG4105E4F Isochorismate synthase HCN55_17280 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HCN55_17285 ENOG4105NIV Esterase HCN55_17305 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HCN55_17315 ENOG41069ER domain protein HCN55_17330 ENOG4105CEP NADH dehydrogenase HCN55_17335 ENOG4105CAY ferredoxin--nadp reductase HCN55_17355 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HCN55_17360 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HCN55_17375 ENOG4105ZKE UPF0349 protein HCN55_17390 ENOG41083MR nifu domain-containing protein HCN55_17395 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HCN55_17400 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HCN55_17405 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HCN55_17410 ENOG4105D6E homoserine dehydrogenase HCN55_17420 ENOG4108W5N phosphatidylglycerophosphatase a HCN55_17425 ENOG4105D4U had-superfamily hydrolase, subfamily iia HCN55_17435 ENOG4105MMD transcriptional regulator HCN55_17440 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HCN55_17445 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HCN55_17450 ENOG4105FAA peptidase M23 HCN55_17455 ENOG4108YTE sporulation protein YunB HCN55_17460 ENOG4105KZD Domain of unknown function (DUF1805) HCN55_17465 ENOG4107R8B 5'-nucleotidase HCN55_17475 ENOG4105I3N Conserved Protein HCN55_17490 ENOG4105G9B Transcriptional regulator HCN55_17505 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HCN55_17510 ENOG4105VT2 5-hydroxyisourate hydrolase HCN55_17520 ENOG4107YV9 domain protein HCN55_17525 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HCN55_17540 ENOG4105XRQ Xanthine dehydrogenase accessory factor HCN55_17545 ENOG4105C5R Aminotransferase HCN55_17560 ENOG4108K8S endonuclease I HCN55_17565 ENOG4108IJ9 (ABC) transporter HCN55_17575 ENOG4108KPW sugar kinase HCN55_17580 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HCN55_17585 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HCN55_17590 ENOG4105XN3 extracellular solute-binding protein family 1 HCN55_17595 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HCN55_17600 ENOG4105PKS Excinuclease abc c subunit domain protein HCN55_17605 ENOG4107VFR oxidoreductase HCN55_17620 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HCN55_17625 ENOG4105NPE arsR family transcriptional regulator HCN55_17630 ENOG4105DIW FeS assembly protein SUFB HCN55_17635 ENOG4108UNV SUF system FeS assembly protein, NifU family HCN55_17640 ENOG4105C9B Cysteine desulfurase HCN55_17645 ENOG4105JRK feS assembly protein SufD HCN55_17650 ENOG4105C3K feS assembly ATPase SufC HCN55_17665 ENOG4105D01 (LipO)protein HCN55_17670 ENOG4108UMI ABC transporter, permease HCN55_17675 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HCN55_17700 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HCN55_17705 ENOG41080E8 Transcriptional regulator, Spx MgsR family HCN55_17710 ENOG4105C1G acyl-Coa dehydrogenase HCN55_17715 ENOG4105CHU acetyl-coa acetyltransferase HCN55_17745 ENOG41067TZ transcriptional regulator, MarR family HCN55_17750 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCN55_17755 ENOG4105MDS 4-oxalocrotonate tautomerase HCN55_17765 ENOG4105EGI Transcriptional regulator HCN55_17775 ENOG4105E0A ABC, transporter HCN55_17790 ENOG4105E1F short-chain dehydrogenase reductase HCN55_17795 ENOG4105HUF DNA protection during starvation protein HCN55_17800 ENOG4105C0H protease HCN55_17810 ENOG4105F3H Histidine kinase HCN55_17820 ENOG41067SE Tetr family transcriptional regulator HCN55_17825 ENOG4105C9Q fumarate hydratase class II HCN55_17850 ENOG4105WH1 Two component transcriptional regulator luxr family HCN55_17855 ENOG4105ENE Histidine kinase HCN55_17870 ENOG41087YS Phage shock protein A HCN55_17885 ENOG4108WBT adenosyltransferase HCN55_17890 ENOG4105E0A ABC, transporter HCN55_17895 ENOG4105EHG Permease protein HCN55_17900 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HCN55_17905 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HCN55_17910 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HCN55_17920 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HCN55_17930 ENOG4106DF4 Sigma-70, region 4 HCN55_17940 ENOG4105F0F Oxalate decarboxylase HCN55_17950 ENOG4107RBB ABC transporter, permease HCN55_17955 ENOG4105C19 ABC transporter HCN55_17960 ENOG4108WMK Efflux transporter RND family MFP subunit HCN55_17965 ENOG4105E0A ABC, transporter HCN55_17970 ENOG4105EHG Permease protein HCN55_17975 ENOG4105DQ5 transport system permease protein HCN55_17985 ENOG4105D5Q Arginine ornithine antiporter HCN55_17995 ENOG4107K5X Membrane-bound metal-dependent hydrolase HCN55_18000 ENOG4107QZ2 Sulfatase HCN55_18005 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HCN55_18010 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HCN55_18015 ENOG4105E0C molybdate abc transporter HCN55_18030 ENOG4105EEQ Na H antiporter HCN55_18035 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HCN55_18040 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HCN55_18045 ENOG4105EEM helicase HCN55_18050 ENOG4105EN6 Membrane HCN55_18060 ENOG4107ZQN disulfide bond HCN55_18065 ENOG4105C59 p-type ATPase HCN55_18070 ENOG4105C59 p-type ATPase HCN55_18075 ENOG410681U heavy metal transport detoxification protein HCN55_18080 ENOG4105VPX protein, conserved in bacteria HCN55_18085 ENOG4105D9R oxidoreductase HCN55_18090 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HCN55_18095 ENOG4105ME7 Membrane HCN55_18100 ENOG4105RXJ HCN55_18105 ENOG4105KPY Small multidrug resistance protein HCN55_18110 ENOG4105KBX Transcriptional regulator, TetR family HCN55_18115 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HCN55_18125 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HCN55_18130 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HCN55_18140 ENOG4105XZU Preprotein translocase, subunit SecG HCN55_18165 ENOG4105KVH Transcriptional regulator HCN55_18170 ENOG4105C8Q Methyl-accepting chemotaxis HCN55_18175 ENOG4105R40 Glycine betaine carnitine choline HCN55_18180 ENOG4108HQR Glycine betaine HCN55_18185 ENOG4105E90 ABC transporter HCN55_18190 ENOG4108IJ8 ABC transporter HCN55_18195 ENOG4107HG4 Transcriptional regulator HCN55_18205 ENOG4105H5S HCN55_18220 ENOG41082BM Transcriptional regulator, arsr family HCN55_18225 ENOG4105R40 Glycine betaine carnitine choline HCN55_18230 ENOG4108HQR Glycine betaine HCN55_18235 ENOG4105E90 ABC transporter HCN55_18240 ENOG4108IJ8 ABC transporter HCN55_18245 ENOG4107HG4 Transcriptional regulator HCN55_18250 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HCN55_18255 ENOG4108QCI YvbH-like oligomerisation region HCN55_18265 ENOG4105T65 Membrane-associated protein HCN55_18270 ENOG4108W0I acetyltransferase HCN55_18275 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HCN55_18280 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HCN55_18285 ENOG4105CP7 Triose-phosphate isomerase HCN55_18290 ENOG4105BZA Phosphoglycerate kinase HCN55_18295 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HCN55_18310 ENOG4105CMD Transcriptional regulator, GntR family HCN55_18315 ENOG4105DEN Luciferase family HCN55_18320 ENOG4105GZI Transcriptional regulator HCN55_18325 ENOG4107RT3 EamA-like transporter family HCN55_18335 ENOG4105VRS hydrolase family 18 HCN55_18340 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HCN55_18345 ENOG4107QR9 Iron-sulfur cluster binding protein HCN55_18350 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HCN55_18360 ENOG4105BZU Histidine kinase HCN55_18365 ENOG4105KCT ABC transporter HCN55_18370 ENOG4108M15 ABC transporter HCN55_18375 ENOG4107R6F Alpha Beta Hydrolase Fold protein HCN55_18380 ENOG4108MJI response regulator HCN55_18395 ENOG4105EG2 ABC transporter, permease HCN55_18405 ENOG4107FKK extracellular solute-binding protein family 1 HCN55_18415 ENOG4105JXH GntR family transcriptional regulator HCN55_18420 ENOG4105DAA L-lactate HCN55_18425 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCN55_18435 ENOG4108ZPC Polysaccharide pyruvyl transferase HCN55_18440 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HCN55_18445 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HCN55_18450 ENOG4105D3Q Sugar transferase HCN55_18460 ENOG4105K64 Glycosyl transferase, family 2 HCN55_18470 ENOG4107QRS glycosyltransferase group 2 family protein HCN55_18475 ENOG41068W6 Capsular polysaccharide biosynthesis protein HCN55_18480 ENOG4108KMV Glycosyl transferase (Group 1 HCN55_18485 ENOG4105K64 Glycosyl transferase, family 2 HCN55_18490 ENOG4108PQP glycosyl transferase group 1 HCN55_18500 ENOG4108QV3 biosynthesis protein HCN55_18505 ENOG4105HTX biosynthesis protein HCN55_18515 ENOG4105EBR Carboxylesterase HCN55_18525 ENOG4105PY6 Phenolic acid decarboxylase HCN55_18530 ENOG4105NI3 Protein of unknown function (DUF3237) HCN55_18540 ENOG4105FQP Beta-lactamase HCN55_18545 ENOG4105EDQ levansucrase EC 2.4.1.10 HCN55_18550 ENOG4108HKT sucrose-6-phosphate hydrolase HCN55_18555 ENOG4107QTZ amino acid HCN55_18580 ENOG4105DNP FAD linked oxidase domain protein HCN55_18585 ENOG4105IRW patatin-like phospholipase family protein HCN55_18595 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HCN55_18600 ENOG4107URF beta-phospho-glucomutase HCN55_18605 ENOG4105CG3 alpha amylase, catalytic region HCN55_18620 ENOG4105EG2 ABC transporter, permease HCN55_18625 ENOG4105D56 permease protein HCN55_18630 ENOG4107FKK extracellular solute-binding protein family 1 HCN55_18635 ENOG4108IUK alpha amylase, catalytic HCN55_18640 ENOG4105FKQ transcriptional regulator HCN55_18645 ENOG4108URH decarboxylase HCN55_18650 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HCN55_18655 ENOG4105CHH sulfate transporter HCN55_18660 ENOG4108V2W Carbonate dehydratase HCN55_18665 ENOG4105C5I Dehydrogenase HCN55_18675 ENOG4105C19 ABC transporter HCN55_18680 ENOG4105EWM Histidine kinase HCN55_18690 ENOG4107A6P HCN55_18695 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HCN55_18700 ENOG4105KRI phosphocarrier protein (HPr HCN55_18705 ENOG4105CIE May be required for sporulation (By similarity) HCN55_18710 ENOG4105CHW UPF0052 protein HCN55_18715 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HCN55_18720 ENOG4108Z4K mutator MutT protein HCN55_18725 ENOG4105C3M thioredoxin reductase HCN55_18740 ENOG4105BZ1 (ABC) transporter HCN55_18750 ENOG4106FGC HCN55_18760 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HCN55_18765 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HCN55_18770 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HCN55_18775 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HCN55_18780 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HCN55_18785 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HCN55_18790 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HCN55_18795 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HCN55_18805 ENOG4108E16 pectate lyase HCN55_18810 ENOG4108S4C acetyltransferase HCN55_18815 ENOG4107XGZ Hydrolase HCN55_18820 ENOG4105HKU nucleoside recognition domain-containing protein HCN55_18825 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HCN55_18830 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HCN55_18835 ENOG4105CE4 GlcNAc 6-P deacetylase HCN55_18840 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HCN55_18850 ENOG41088CQ domain protein HCN55_18860 ENOG4106A3M Cytochrome p-450 HCN55_18865 ENOG410625E HCN55_18880 ENOG41086DT Membrane protein of unknown function HCN55_18885 ENOG41067S9 phage shock protein C, PspC HCN55_18890 ENOG4108PY7 HCN55_18910 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HCN55_18915 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HCN55_18930 ENOG4105MKU Transcriptional regulator HCN55_18950 ENOG4105CN1 protease HCN55_18955 ENOG4105CRP Part of the ABC transporter FtsEX involved in HCN55_18960 ENOG4105CAK Cell division ATP-binding protein ftsE HCN55_18985 ENOG4105MS2 ribosomal subunit Interface protein HCN55_19000 ENOG4105MQ3 flagellar protein FliS HCN55_19005 ENOG4107RT6 flagellar hook-associated HCN55_19010 ENOG41083S7 flagellar protein FlaG HCN55_19015 ENOG4105I03 Flagellin HCN55_19020 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HCN55_19025 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HCN55_19030 ENOG4105MKD HCN55_19040 ENOG4105E1Q flagellar hook-associated protein HCN55_19055 ENOG4105RU3 HCN55_19060 ENOG41081UC Inherit from COG: Competence protein HCN55_19080 ENOG4105WH1 Two component transcriptional regulator luxr family HCN55_19085 ENOG4105BZU Histidine kinase HCN55_19090 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HCN55_19095 ENOG4108KGH TRANSCRIPTIONal HCN55_19100 ENOG4105ESV Glycosyl transferase, family 4 HCN55_19105 ENOG4107EF8 Glycosyl transferase (Group 1 HCN55_19120 ENOG4105QZI O-Antigen Polymerase HCN55_19125 ENOG4105C6Y Udp-glucose 6-dehydrogenase HCN55_19130 ENOG4107RA4 Glycosyl transferase (Group 1 HCN55_19135 ENOG4105PSV Polysaccharide Biosynthesis Protein HCN55_19145 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HCN55_19150 ENOG4105JFG SpoIID LytB domain protein HCN55_19165 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HCN55_19170 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HCN55_19185 ENOG41088M2 Glycosyl transferase family 2 HCN55_19195 ENOG4107SJB teichoic acid biosynthesis HCN55_19205 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HCN55_19210 ENOG4105EY8 ABC transporter HCN55_19220 ENOG4107SJB teichoic acid biosynthesis HCN55_19225 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HCN55_19230 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HCN55_19240 ENOG4107RZX Teichoic acid biosynthesis protein HCN55_19245 ENOG410651K Teichoic acid biosynthesis protein C HCN55_19255 ENOG4105DG6 mannose-6-phosphate isomerase HCN55_19270 ENOG4108NHD germination protein HCN55_19275 ENOG4105C54 Major Facilitator superfamily HCN55_19280 ENOG4108KGH TRANSCRIPTIONal HCN55_19285 ENOG4105J7I hydrolase HCN55_19290 ENOG4105K4H Nlp p60 protein HCN55_19300 ENOG4105PNM synthesis protein HCN55_19310 ENOG4105N98 Capsule biosynthesis protein capB HCN55_19315 ENOG4105ETE Transcriptional regulator (LacI family HCN55_19320 ENOG4108RVA ribokinase HCN55_19325 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HCN55_19330 ENOG4105C2J ABC transporter HCN55_19335 ENOG4105CNN ABC, transporter HCN55_19340 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HCN55_19355 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HCN55_19360 ENOG4107FQX Alpha-acetolactate decarboxylase HCN55_19370 ENOG4107RSM transcriptional regulator HCN55_19385 ENOG4106UIA HCN55_19400 ENOG4107XC4 flavin reductase domain protein, FMN-binding HCN55_19410 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HCN55_19420 ENOG4105CAH Chromate HCN55_19425 ENOG4105FGV Chromate HCN55_19435 ENOG4108WS4 fmn reductase HCN55_19440 ENOG4107V2S Transcriptional regulator HCN55_19445 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HCN55_19450 ENOG4106YAD MORN repeat variant HCN55_19475 ENOG4108XI2 Domain of unknown function (DUF1963) HCN55_19480 ENOG4105C6Y Udp-glucose 6-dehydrogenase HCN55_19485 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HCN55_19490 ENOG4107YJ4 chain length determinant protein HCN55_19495 ENOG4105HTX biosynthesis protein HCN55_19505 ENOG4105KBK Zinc finger, swim domain protein HCN55_19510 ENOG4105C0D helicase HCN55_19515 ENOG410667J hydrolase HCN55_19520 ENOG4105E98 transcriptional regulator DeoR family HCN55_19525 ENOG4105Z8H single-stranded DNA-binding protein HCN55_19555 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HCN55_19560 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HCN55_19570 ENOG4105CGA flagellar basal-body rod protein FlgG HCN55_19580 ENOG4105DFF Rod shape-determining protein mreb HCN55_19585 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HCN55_19595 ENOG4107MII Sugar-specific transcriptional regulator TrmB HCN55_19600 ENOG4105CZM Major Facilitator HCN55_19605 ENOG4108M26 parallel beta-helix repeat protein HCN55_19610 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HCN55_19615 ENOG41080V3 Major Facilitator superfamily HCN55_19620 ENOG4105D3W isochorismatase HCN55_19625 ENOG4107P26 HCN55_19630 ENOG4105BZU Histidine kinase HCN55_19640 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HCN55_19650 ENOG4105FRN stage II sporulation protein HCN55_19655 ENOG4107TCE N-acetyltransferase HCN55_19675 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HCN55_19680 ENOG4107TXC Transcriptional regulator HCN55_19685 ENOG4106BRK HCN55_19690 ENOG4108RYK Nad-dependent epimerase dehydratase HCN55_19695 ENOG4108Z40 Transcriptional regulator HCN55_19700 ENOG4105CQM Urea amidohydrolase subunit alpha HCN55_19705 ENOG4105KI2 Urea amidohydrolase subunit beta HCN55_19710 ENOG4108YZ9 Urea amidohydrolase subunit gamma HCN55_19745 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HCN55_19755 ENOG4108TF4 von Willebrand factor, type A HCN55_19770 ENOG4105JFG SpoIID LytB domain protein HCN55_19775 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HCN55_19785 ENOG4106778 Protein of unknown function (DUF1146) HCN55_19795 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HCN55_19800 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HCN55_19805 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HCN55_19810 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HCN55_19830 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) HCN55_19840 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HCN55_19845 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HCN55_19850 ENOG4108UIC UPF0340 protein HCN55_19855 ENOG4108YZG isomerase HCN55_19860 ENOG4107WAU Protein tyrosine phosphatase HCN55_19865 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HCN55_19870 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HCN55_19880 ENOG4108ZXQ stage ii sporulation protein r HCN55_19895 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HCN55_19900 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HCN55_19905 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HCN55_19915 ENOG4107TT2 Auxin Efflux Carrier HCN55_19920 ENOG4105C6K Malic enzyme HCN55_19925 ENOG4107104 thymidine kinase HCN55_19935 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HCN55_19945 ENOG4105CBT Fructose-1,6-bisphosphatase HCN55_19950 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HCN55_19955 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway HCN55_19960 ENOG4105D2N Aldolase HCN55_19965 ENOG410812K response regulator receiver protein HCN55_19975 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HCN55_19985 ENOG4105C1G acyl-Coa dehydrogenase HCN55_19990 ENOG4105DF6 Fe-S oxidoreductase HCN55_20000 ENOG4105E5J UV damage endonuclease HCN55_20010 ENOG4105NAE bifunctional deaminase-reductase domain protein HCN55_20015 ENOG4105BZ1 (ABC) transporter HCN55_20020 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HCN55_20035 ENOG4105R3A Nitrate reductase HCN55_20040 ENOG4108IUE nitrate reductase beta subunit HCN55_20060 ENOG4107V6Q Cyclic nucleotide-binding domain HCN55_20070 ENOG4105C75 arginyL-tRNA synthetase HCN55_20075 ENOG410684U Domain of unknown function (DUF1934) HCN55_20090 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HCN55_20140 ENOG4107JM4 Tetratricopeptide repeat HCN55_20150 ENOG4108UIN ybak prolyl-trna synthetase associated region HCN55_20155 ENOG4105CYW agmatinase HCN55_20160 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HCN55_20165 ENOG4105BZ4 penicillin-binding protein HCN55_20170 ENOG4108XFG YwhD family HCN55_20175 ENOG4108Z4T Peptidase M50 HCN55_20180 ENOG41069HH 4-oxalocrotonate tautomerase HCN55_20185 ENOG41067TZ transcriptional regulator, MarR family HCN55_20190 ENOG4105C22 threonyL-tRNA synthetase HCN55_20195 ENOG4105C57 major facilitator superfamily HCN55_20200 ENOG41062ES Transcriptional regulator HCN55_20210 ENOG4105DCI Phosphohydrolase HCN55_20220 ENOG4108VCI transcription factor, rsfa family HCN55_20225 ENOG4108RNG Permease of the drug metabolite transporter HCN55_20230 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HCN55_20235 ENOG4105DUM transcriptional regulator, lysR family HCN55_20240 ENOG4108IJ2 phosphate acetyltransferase HCN55_20255 ENOG4105CHM Aminotransferase HCN55_20265 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase HCN55_20270 ENOG4105CHR reductase HCN55_20275 ENOG4106CHD Bacilysin biosynthesis protein bacB HCN55_20280 ENOG41061WN bacilysin biosynthesis protein HCN55_20285 ENOG4105FCW Major Facilitator superfamily HCN55_20300 ENOG4105C26 Dehydrogenase HCN55_20305 ENOG4105D82 Glutamate dehydrogenase HCN55_20315 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HCN55_20320 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HCN55_20325 ENOG4105C1B dTDP-glucose 4-6-dehydratase HCN55_20330 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HCN55_20335 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG HCN55_20340 ENOG4107TY6 Acylneuraminate cytidylyltransferase HCN55_20350 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HCN55_20355 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HCN55_20390 ENOG4105C26 Dehydrogenase HCN55_20395 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HCN55_20400 ENOG4108RJ9 Glycosyl transferase, family 2 HCN55_20420 ENOG4105DWF phosphomethylpyrimidine kinase HCN55_20435 ENOG4105C5Y PTS System HCN55_20440 ENOG4108QTI )-transporter HCN55_20455 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HCN55_20460 ENOG4105DEN Luciferase family HCN55_20465 ENOG4108DBC nitroreductase HCN55_20480 ENOG41060D1 Quinol oxidase HCN55_20485 ENOG4105CCU oxidase (Subunit III) HCN55_20490 ENOG4105BZ9 Cytochrome C oxidase, subunit I HCN55_20495 ENOG4105E2S oxidase) subunit II HCN55_20500 ENOG4107BMA Transglycosylase associated protein HCN55_20510 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HCN55_20515 ENOG4105WH5 Teichoic acid glycosylation protein HCN55_20540 ENOG4107ZXU DSBA oxidoreductase HCN55_20545 ENOG4105DBE peroxidase HCN55_20550 ENOG410650H (LipO)protein HCN55_20555 ENOG4107SJW iron permease, FTR1 HCN55_20560 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HCN55_20570 ENOG4105CMU LysR family (Transcriptional regulator HCN55_20575 ENOG4105VAW lrga family HCN55_20580 ENOG41067MG lrgb family HCN55_20585 ENOG4105D8G Major Facilitator superfamily HCN55_20595 ENOG4105DR4 Methyltransferase HCN55_20605 ENOG4108YV3 Protein of unknown function (DUF2711) HCN55_20610 ENOG4105CK1 PTS System HCN55_20615 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HCN55_20630 ENOG4105X1N Glycosyl transferase family 8 HCN55_20640 ENOG4105GVJ transcriptional regulator HCN55_20645 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HCN55_20650 ENOG4105IIU Aminopeptidase HCN55_20660 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HCN55_20675 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HCN55_20680 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HCN55_20690 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HCN55_20695 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HCN55_20700 ENOG4105CM2 brancheD-chain amino acid aminotransferase HCN55_20705 ENOG4105F8D glycoside hydrolase family 4 HCN55_20710 ENOG4105VCP PTS System HCN55_20715 ENOG4105CK1 PTS System HCN55_20720 ENOG4105VZJ PTS System HCN55_20725 ENOG4105EMD TRANSCRIPTIONal HCN55_20735 ENOG4108VX5 3-methyladenine DNA glycosylase HCN55_20740 ENOG4105CH6 catalase HCN55_20755 ENOG4105DA5 (ABC) transporter HCN55_20760 ENOG41069JR HCN55_20780 ENOG4105ETS cytosine purines uracil thiamine allantoin HCN55_20785 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HCN55_20790 ENOG4108JJ8 (ABC) transporter HCN55_20795 ENOG4108JJ9 ABC, transporter HCN55_20800 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HCN55_20805 ENOG4105C4M (Ubiquinol oxidase) subunit I HCN55_20810 ENOG4105D2K citrate carrier protein HCN55_20825 ENOG4107BJW polysaccharide deacetylase HCN55_20845 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HCN55_20855 ENOG4105CMR udp-glucose 4-epimerase HCN55_20860 ENOG4105KIS phospholipid-binding protein HCN55_20865 ENOG4108WAV Transcriptional regulator HCN55_20875 ENOG4105BZU Histidine kinase HCN55_20880 ENOG4105WH1 Two component transcriptional regulator luxr family HCN55_20885 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HCN55_20910 ENOG4105DTD Dehydrogenase HCN55_20915 ENOG4108IIH CoA-transferase subunit B HCN55_20920 ENOG4105D6N CoA-transferase, subunit a HCN55_20925 ENOG4105CY2 Citrate transporter HCN55_20930 ENOG4105DHI Methyltransferase HCN55_20950 ENOG4105CH6 catalase HCN55_20955 ENOG4105D4T Citrate transporter HCN55_20960 ENOG4108RZ2 Glycoside hydrolase family 16 HCN55_20965 ENOG4105CID antiterminator HCN55_20975 ENOG4105DEU major facilitator superfamily HCN55_20980 ENOG4105C1J atp-dependent rna helicase HCN55_20985 ENOG4107TDE lipolytic protein G-D-S-L family HCN55_21040 ENOG4105CNA YD repeat protein HCN55_21050 ENOG4107YZX Universal stress protein HCN55_21055 ENOG4105CS2 ec 3.2.1.21 HCN55_21060 ENOG4105C5Y PTS System HCN55_21075 ENOG4107EV6 Inherit from COG: YD repeat protein HCN55_21090 ENOG4106Z5D Glycoside Hydrolase Family 43 HCN55_21105 ENOG4105C84 Histidine ammonia-lyase HCN55_21110 ENOG4105CGP Urocanate hydratase HCN55_21115 ENOG4105CI2 imidazolone-5-propionate hydrolase HCN55_21120 ENOG4107W25 arginase agmatinase formiminoglutamase HCN55_21130 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HCN55_21135 ENOG4105D9N nucleoside HCN55_21145 ENOG4107RHR regulatoR HCN55_21150 ENOG4108TM9 integral membrane protein HCN55_21155 ENOG4105ENY Ethanolamine utilization protein eutH HCN55_21160 ENOG4108PGP mmge prpd family protein HCN55_21175 ENOG4108HW4 amino acid AbC transporter HCN55_21180 ENOG4105EAB amino acid AbC transporter HCN55_21200 ENOG4107QHE Choloylglycine hydrolase HCN55_21205 ENOG410667J hydrolase HCN55_21235 ENOG4108V5C ABC transporter HCN55_21265 ENOG4105D2N Aldolase HCN55_21270 ENOG4107TRN Xylose isomerase domain protein TIM barrel HCN55_21275 ENOG4105F0H myo-inositol catabolism protein HCN55_21280 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HCN55_21290 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HCN55_21295 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HCN55_21300 ENOG4105D7K pfkb domain protein HCN55_21305 ENOG4105DH8 myo-inositol catabolism HCN55_21310 ENOG4105C26 Dehydrogenase HCN55_21320 ENOG4105CPC Aldo Keto reductase HCN55_21335 ENOG4107QNK )-transporter HCN55_21340 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HCN55_21350 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HCN55_21355 ENOG4105ST3 Transcriptional regulator HCN55_21360 ENOG4105C26 Dehydrogenase HCN55_21365 ENOG4108YM7 Gcn5-related n-acetyltransferase HCN55_21370 ENOG4105N1N Cupin superfamily protein HCN55_21375 ENOG4107Y1Y Methyltransferase HCN55_21390 ENOG4105CAQ asparagine synthetase HCN55_21395 ENOG4105F22 Major Facilitator Superfamily HCN55_21400 ENOG4108ITS PQQ enzyme repeat HCN55_21410 ENOG41085PJ rdd domain containing protein HCN55_21425 ENOG4105J7D transcriptional regulator HCN55_21430 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HCN55_21435 ENOG41061AU MarR family Transcriptional regulator HCN55_21445 ENOG41067MG lrgb family HCN55_21455 ENOG4105BZW Glycerate kinase HCN55_21460 ENOG4105G3Z GntR family transcriptional regulator HCN55_21465 ENOG4105CMG Carbohydrate kinase HCN55_21470 ENOG4105C6Z Gluconate HCN55_21475 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HCN55_21480 ENOG4105D3R alkyl hydroperoxide reductase HCN55_21485 ENOG4108JU3 Alkyl hydroperoxide reductase HCN55_21490 ENOG4105CS2 ec 3.2.1.21 HCN55_21505 ENOG4108S3Y transcriptional regulator HCN55_21515 ENOG4106KKU HCN55_21520 ENOG4108Z15 abc transporter atp-binding protein HCN55_21530 ENOG4105Y2Z radical SAM domain protein HCN55_21540 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HCN55_21555 ENOG41069I7 HCN55_21560 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HCN55_21575 ENOG4105E2A Dehydrogenase HCN55_21595 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HCN55_21600 ENOG4105WQG acetyltransferase HCN55_21605 ENOG410780I phosphoprotein phosphatase activity HCN55_21615 ENOG41066UZ arginase EC 3.5.3.1 HCN55_21620 ENOG4108IQI permease HCN55_21625 ENOG4105C8Y Acetylornithine aminotransferase HCN55_21630 ENOG4108JUB Transcriptional regulator HCN55_21650 ENOG4105C0H protease HCN55_21655 ENOG4105Q2H domain protein HCN55_21670 ENOG4105BZU Histidine kinase HCN55_21675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCN55_21700 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HCN55_21705 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HCN55_21710 ENOG4105CDU Replicative dna helicase HCN55_21730 ENOG4105DJ2 Major Facilitator Superfamily HCN55_21735 ENOG4105EDW glycosyl transferase, family 39 HCN55_21740 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HCN55_21745 ENOG4105BZR domain protein HCN55_21750 ENOG4108XMW Membrane HCN55_21765 ENOG4105KVH Transcriptional regulator HCN55_21770 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HCN55_21800 ENOG41060CM Protein of unknown function (DUF2712) HCN55_21805 ENOG4106NWU HCN55_21810 ENOG41064J9 HCN55_21815 ENOG41064SH Protein of unknown function (DUF2705) HCN55_21820 ENOG4108RDQ ABC transporter HCN55_21835 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HCN55_21840 ENOG4105DDN Pentapeptide repeat-containing protein HCN55_21845 ENOG4105D94 Major Facilitator Superfamily HCN55_21850 ENOG4107RSM transcriptional regulator HCN55_21855 ENOG41082BV acetyltransferase HCN55_21860 ENOG41081I9 integral membrane protein HCN55_21875 ENOG4108U05 Transcriptional regulator HCN55_21880 ENOG41082BV acetyltransferase HCN55_21890 ENOG4108U7W acetyltransferase HCN55_21895 ENOG4105UNS Pfam:DUF419 HCN55_21900 ENOG4105NAE bifunctional deaminase-reductase domain protein HCN55_21910 ENOG4108J8C transporter major facilitator family protein HCN55_21930 ENOG4108IPJ Membrane HCN55_21935 ENOG4105C7Z Conserved Protein HCN55_21940 ENOG4107FCW Abortive infection protein HCN55_21950 ENOG4108UW5 maltose o-acetyltransferase HCN55_21955 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HCN55_21965 ENOG4105CGK Exodeoxyribonuclease III HCN55_21970 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HCN55_21975 ENOG4108UUM single-stranded DNA-binding protein HCN55_21980 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HCN55_21985 ENOG4105C3G gtp-binding protein HCN55_21990 ENOG4108J2R molybdopterin oxidoreductase HCN55_21995 ENOG4105VDK protein, conserved in bacteria HCN55_22005 ENOG4108ZDA Sporulation protein YyaC HCN55_22010 ENOG4105FA0 parb-like partition protein HCN55_22015 ENOG4107QJE Chromosome Partitioning Protein HCN55_22030 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HCN55_22035 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HCN55_22040 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HCN55_22055 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)