locus-tag	class	description
G4P54_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G4P54_00010	COG0592	DNA-directed DNA polymerase activity
G4P54_00015	COG2501	S4 domain
G4P54_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4P54_00030	COG0187	DNA topoisomerase II activity
G4P54_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4P54_00070	COG0517	IMP dehydrogenase activity
G4P54_00070	COG0516	GMP reductase activity
G4P54_00075	COG1686	Belongs to the peptidase S11 family
G4P54_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
G4P54_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G4P54_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G4P54_00100	COG1428	Deoxynucleoside kinase
G4P54_00105	COG1428	Deoxynucleoside kinase
G4P54_00110	COG3858	chitin binding
G4P54_00110	COG1388	LysM domain
G4P54_00115	COG1335	isochorismatase
G4P54_00120	COG0590	tRNA wobble adenosine to inosine editing
G4P54_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4P54_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G4P54_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G4P54_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
G4P54_00190	COG3853	Toxic anion resistance protein (TelA)
G4P54_00195	COG1982	Orn Lys Arg decarboxylase major
G4P54_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4P54_00205	COG3870	Protein conserved in bacteria
G4P54_00210	COG1728	Protein conserved in bacteria
G4P54_00215	COG0470	DNA polymerase III
G4P54_00220	COG1774	PSP1 C-terminal conserved region
G4P54_00225	COG4467	Involved in initiation control of chromosome replication
G4P54_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G4P54_00235	COG2827	Endonuclease containing a URI domain
G4P54_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G4P54_00245	COG2002	toxin-antitoxin pair type II binding
G4P54_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4P54_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4P54_00255	COG0084	hydrolase, TatD family'
G4P54_00260	COG3583	domain protein
G4P54_00260	COG3584	3D domain protein
G4P54_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
G4P54_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G4P54_00280	COG4466	Protein conserved in bacteria
G4P54_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G4P54_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4P54_00300	COG0251	oxidation-reduction process
G4P54_00305	COG2088	sporulation resulting in formation of a cellular spore
G4P54_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4P54_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4P54_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G4P54_00325	COG0193	aminoacyl-tRNA hydrolase activity
G4P54_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4P54_00340	COG2002	toxin-antitoxin pair type II binding
G4P54_00345	COG2244	polysaccharide biosynthetic process
G4P54_00350	COG3956	TIGRFAM MazG family protein
G4P54_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G4P54_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G4P54_00375	COG1098	S1 RNA binding domain
G4P54_00390	COG2208	phosphoserine phosphatase activity
G4P54_00395	COG2304	oxidoreductase activity
G4P54_00400	COG0515	serine threonine protein kinase
G4P54_00405	COG0037	tRNA processing
G4P54_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4P54_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G4P54_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G4P54_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4P54_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4P54_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4P54_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
G4P54_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4P54_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G4P54_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4P54_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4P54_00470	COG1396	sequence-specific DNA binding
G4P54_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4P54_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4P54_00560	COG4463	regulation of RNA biosynthetic process
G4P54_00565	COG3880	PFAM UvrB UvrC protein
G4P54_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
G4P54_00575	COG0542	response to heat
G4P54_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G4P54_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
G4P54_00590	COG4956	integral membrane protein (PIN domain superfamily)
G4P54_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G4P54_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G4P54_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4P54_00610	COG1045	serine acetyltransferase
G4P54_00615	COG0215	cysteine-tRNA ligase activity
G4P54_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G4P54_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4P54_00630	COG3688	RNA-binding protein containing a PIN domain
G4P54_00635	COG1595	DNA-templated transcription, initiation
G4P54_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4P54_00650	COG0250	Participates in transcription elongation, termination and antitermination
G4P54_00660	COG0081	regulation of translation
G4P54_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G4P54_00675	COG2813	Specifically methylates the guanine in position
G4P54_00680	COG0085	RNA polymerase activity
G4P54_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G4P54_00690	COG1358	cellular component organization or biogenesis
G4P54_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G4P54_00700	COG0049	tRNA binding
G4P54_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4P54_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4P54_00715	COG0596	Alpha beta hydrolase
G4P54_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G4P54_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4P54_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G4P54_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G4P54_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G4P54_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G4P54_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4P54_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G4P54_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G4P54_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4P54_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G4P54_00820	COG0200	Binds to the 23S rRNA
G4P54_00825	COG0201	protein transport
G4P54_00830	COG0563	adenylate kinase activity
G4P54_00835	COG0024	Methionine aminopeptidase
G4P54_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
G4P54_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4P54_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G4P54_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G4P54_00865	COG0202	RNA polymerase activity
G4P54_00870	COG0203	ribosomal protein L17
G4P54_00875	COG1122	ATPase activity
G4P54_00880	COG1122	ATPase activity
G4P54_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G4P54_00890	COG0101	tRNA pseudouridine synthase activity
G4P54_00905	COG2226	methyltransferase
G4P54_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4P54_00920	COG0489	protein tyrosine kinase activity
G4P54_00930	COG2194	sulfuric ester hydrolase activity
G4P54_00935	COG0726	polysaccharide deacetylase
G4P54_01025	COG0385	Bile acid
G4P54_01030	COG2819	hydrolase of the alpha beta superfamily
G4P54_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4P54_01050	COG2207	Transcriptional regulator
G4P54_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4P54_01055	COG3876	Protein conserved in bacteria
G4P54_01060	COG1472	Belongs to the glycosyl hydrolase 3 family
G4P54_01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4P54_01070	COG1263	PTS System
G4P54_01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_01075	COG1737	Transcriptional regulator
G4P54_01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
G4P54_01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4P54_01090	COG1683	Conserved Protein
G4P54_01120	COG1595	DNA-templated transcription, initiation
G4P54_01125	COG5662	AntiSigma factor
G4P54_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G4P54_01135	COG4856	YbbR-like protein
G4P54_01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4P54_01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4P54_01150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4P54_01155	COG3002	Belongs to the UPF0753 family
G4P54_01170	COG5609	conserved protein (DUF2294)
G4P54_01175	COG0640	Transcriptional regulator
G4P54_01180	COG2814	Major facilitator Superfamily
G4P54_01195	COG0535	radical SAM domain protein
G4P54_01200	COG1266	CAAX protease self-immunity
G4P54_01205	COG1131	(ABC) transporter
G4P54_01215	COG1413	lyase activity
G4P54_01220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_01225	COG0596	Alpha beta hydrolase
G4P54_01230	COG0745	RESPONSE REGULATOR receiver
G4P54_01235	COG0642	Histidine kinase
G4P54_01245	COG0515	serine threonine protein kinase
G4P54_01260	COG1113	amino acid transport
G4P54_01275	COG2124	cytochrome p450
G4P54_01285	COG0531	amino acid
G4P54_01290	COG0584	glycerophosphoryl diester phosphodiesterase
G4P54_01295	COG2271	Major facilitator Superfamily
G4P54_01305	COG1846	Transcriptional regulator
G4P54_01305	COG0456	acetyltransferase
G4P54_01310	COG2271	Major facilitator Superfamily
G4P54_01320	COG0697	spore germination
G4P54_01325	COG1917	Cupin 2, conserved barrel domain protein
G4P54_01325	COG2207	Transcriptional regulator
G4P54_01330	COG1397	ADP-ribosylglycohydrolase
G4P54_01335	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G4P54_01340	COG3591	Belongs to the peptidase S1B family
G4P54_01350	COG0596	Alpha beta hydrolase
G4P54_01355	COG1183	phosphatidylcholine synthase activity
G4P54_01360	COG0586	Pfam SNARE associated Golgi protein
G4P54_01365	COG0688	phosphatidylethanolamine metabolic process
G4P54_01375	COG2312	Erythromycin esterase
G4P54_01380	COG2207	Transcriptional regulator
G4P54_01390	COG1301	dicarboxylic acid transport
G4P54_01395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_01395	COG1263	PTS System
G4P54_01395	COG2190	(PTS) system
G4P54_01400	COG0363	glucosamine-6-phosphate deaminase activity
G4P54_01405	COG2188	Transcriptional regulator
G4P54_01415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4P54_01420	COG0833	amino acid
G4P54_01425	COG2040	homocysteine
G4P54_01430	COG1115	amino acid carrier protein
G4P54_01435	COG2066	Belongs to the glutaminase family
G4P54_01440	COG4191	Histidine kinase
G4P54_01445	COG0784	Response regulator, receiver
G4P54_01450	COG3173	Aminoglycoside phosphotransferase
G4P54_01460	COG0697	spore germination
G4P54_01465	COG0745	RESPONSE REGULATOR receiver
G4P54_01470	COG2205	protein histidine kinase activity
G4P54_01475	COG1131	(ABC) transporter
G4P54_01500	COG3773	Cell wall hydrolase
G4P54_01515	COG3540	Alkaline phosphatase
G4P54_01520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4P54_01525	COG0805	protein transport
G4P54_01530	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
G4P54_01535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4P54_01540	COG0477	Major facilitator Superfamily
G4P54_01545	COG1309	transcriptional regulator
G4P54_01550	COG0252	asparaginase activity
G4P54_01555	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G4P54_01560	COG1714	RDD family
G4P54_01565	COG3012	SEC-C Motif Domain Protein
G4P54_01565	COG1405	negative regulation of cell septum assembly
G4P54_01570	COG3290	protein histidine kinase activity
G4P54_01575	COG3279	Response regulator of the LytR AlgR family
G4P54_01580	COG4555	ABC transporter
G4P54_01585	COG1668	transmembrane transport
G4P54_01590	COG0667	Aldo Keto reductase
G4P54_01605	COG1595	DNA-templated transcription, initiation
G4P54_01610	COG1595	DNA-templated transcription, initiation
G4P54_01615	COG1876	peptidase activity
G4P54_01620	COG0457	Tetratricopeptide repeat
G4P54_01625	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_01630	COG0366	Alpha amylase catalytic
G4P54_01635	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4P54_01640	COG1121	(ABC) transporter
G4P54_01645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4P54_01650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4P54_01655	COG2310	stress, protein
G4P54_01660	COG2310	stress, protein
G4P54_01665	COG2310	stress, protein
G4P54_01670	COG0861	Integral membrane protein TerC family
G4P54_01680	COG3853	Toxic anion resistance protein (TelA)
G4P54_01685	COG0477	Major facilitator Superfamily
G4P54_01690	COG2814	Major facilitator Superfamily
G4P54_01695	COG0640	Transcriptional regulator
G4P54_01700	COG0517	IMP dehydrogenase activity
G4P54_01700	COG4175	Glycine betaine
G4P54_01705	COG4176	ABC-type proline glycine betaine transport system permease component
G4P54_01710	COG2113	Glycine betaine
G4P54_01715	COG1473	amidohydrolase
G4P54_01720	COG1288	antiporter activity
G4P54_01730	COG0366	Alpha amylase catalytic
G4P54_01735	COG0039	L-malate dehydrogenase activity
G4P54_01740	COG1620	l-lactate permease
G4P54_01745	COG2814	Major facilitator Superfamily
G4P54_01750	COG1846	Transcriptional regulator
G4P54_01755	COG1280	lysine exporter protein (LysE YggA)
G4P54_01760	COG3403	YqcI/YcgG family
G4P54_01765	COG1113	amino acid transport
G4P54_01770	COG3665	Urea carboxylase-associated protein
G4P54_01775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G4P54_01780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G4P54_01795	COG0583	DNA-binding transcription factor activity
G4P54_01800	COG3458	cephalosporin-C deacetylase activity
G4P54_01805	COG3541	Predicted nucleotidyltransferase
G4P54_01810	COG0506	proline dehydrogenase activity
G4P54_01815	COG1012	belongs to the aldehyde dehydrogenase family
G4P54_01820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4P54_01825	COG2508	Transcriptional regulator
G4P54_01830	COG3689	TIGRFAM TIGR03943 family protein
G4P54_01835	COG0701	Predicted permease
G4P54_01840	COG2267	carboxylic ester hydrolase activity
G4P54_01845	COG0492	ferredoxin-NADP+ reductase activity
G4P54_01850	COG1587	Uroporphyrinogen-III synthase
G4P54_01850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4P54_01855	COG2146	nitrite reductase [NAD(P)H] activity
G4P54_01860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4P54_01865	COG0243	molybdopterin cofactor binding
G4P54_01870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4P54_01875	COG2223	nitrite transmembrane transporter activity
G4P54_01880	COG0765	amino acid transport
G4P54_01885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4P54_01890	COG1063	alcohol dehydrogenase
G4P54_01895	COG1714	RDD family
G4P54_01905	COG1846	Transcriptional regulator
G4P54_01915	COG3842	ATPase activity
G4P54_01930	COG3209	COG3209 Rhs family protein
G4P54_01935	COG0840	transmembrane signaling receptor activity
G4P54_01935	COG3290	protein histidine kinase activity
G4P54_01940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G4P54_01945	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
G4P54_01950	COG1733	regulation of RNA biosynthetic process
G4P54_01955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_01960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_01970	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
G4P54_01990	COG2364	Membrane
G4P54_01995	COG1126	abc transporter atp-binding protein
G4P54_02000	COG0765	amino acid transport
G4P54_02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4P54_02010	COG0583	DNA-binding transcription factor activity
G4P54_02015	COG0163	prenyltransferase activity
G4P54_02020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G4P54_02035	COG3104	oligopeptide transport
G4P54_02040	COG5434	Belongs to the glycosyl hydrolase 28 family
G4P54_02050	COG0697	spore germination
G4P54_02060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G4P54_02070	COG0457	Tetratricopeptide repeat
G4P54_02085	COG0527	aspartate kinase activity
G4P54_02090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_02095	COG4605	iron ion homeostasis
G4P54_02100	COG4604	ABC transporter, ATP-binding protein
G4P54_02105	COG4607	ABC-type enterochelin transport system periplasmic component
G4P54_02110	COG2814	Major facilitator Superfamily
G4P54_02115	COG1309	transcriptional regulator
G4P54_02120	COG0778	Nitroreductase
G4P54_02125	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
G4P54_02130	COG0640	Transcriptional regulator
G4P54_02135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4P54_02140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4P54_02145	COG1012	belongs to the aldehyde dehydrogenase family
G4P54_02150	COG4975	Glucose uptake
G4P54_02155	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_02160	COG4549	nuclear export factor GLE1
G4P54_02165	COG2372	response to copper ion
G4P54_02165	COG1276	copper resistance
G4P54_02170	COG1349	DNA-binding transcription factor activity
G4P54_02180	COG2213	PTS system mannitol-specific
G4P54_02185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4P54_02190	COG0246	Mannitol dehydrogenase
G4P54_02195	COG0473	3-isopropylmalate dehydrogenase activity
G4P54_02200	COG0681	Belongs to the peptidase S26 family
G4P54_02205	COG0412	Dienelactone hydrolase
G4P54_02210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4P54_02220	COG0561	phosphatase activity
G4P54_02225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G4P54_02230	COG1914	H( )-stimulated, divalent metal cation uptake system
G4P54_02235	COG4336	lyase activity
G4P54_02240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G4P54_02245	COG1984	allophanate hydrolase subunit 2
G4P54_02250	COG1414	Transcriptional regulator
G4P54_02255	COG2755	lipolytic protein G-D-S-L family
G4P54_02265	COG2329	Antibiotic biosynthesis monooxygenase
G4P54_02270	COG0768	penicillin binding
G4P54_02275	COG4989	oxidoreductase activity
G4P54_02280	COG3711	transcriptional antiterminator
G4P54_02285	COG0318	PFAM AMP-dependent synthetase and ligase
G4P54_02290	COG2226	methyltransferase
G4P54_02295	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_02300	COG1917	Cupin 2, conserved barrel domain protein
G4P54_02305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4P54_02310	COG3871	stress protein (general stress protein 26)
G4P54_02320	COG2814	Major facilitator Superfamily
G4P54_02325	COG1522	sequence-specific DNA binding
G4P54_02330	COG0551	DNA topoisomerase type I activity
G4P54_02330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4P54_02335	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
G4P54_02340	COG3706	GGDEF domain
G4P54_02345	COG5298	Protein conserved in bacteria
G4P54_02350	COG1215	transferase activity, transferring glycosyl groups
G4P54_02360	COG0531	amino acid
G4P54_02365	COG0494	nUDIX hydrolase
G4P54_02370	COG0028	Belongs to the TPP enzyme family
G4P54_02380	COG1914	H( )-stimulated, divalent metal cation uptake system
G4P54_02385	COG2261	transglycosylase associated protein
G4P54_02390	COG4876	unkown
G4P54_02395	COG2217	Heavy metal translocating P-type atpase
G4P54_02400	COG3729	General stress protein
G4P54_02405	COG0662	Cupin 2, conserved barrel domain protein
G4P54_02410	COG2329	Antibiotic biosynthesis monooxygenase
G4P54_02415	COG3546	catalase activity
G4P54_02420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G4P54_02425	COG3290	protein histidine kinase activity
G4P54_02430	COG4565	transcriptional regulatory protein
G4P54_02435	COG1301	dicarboxylic acid transport
G4P54_02440	COG0628	permease
G4P54_02445	COG1301	dicarboxylic acid transport
G4P54_02450	COG1131	(ABC) transporter
G4P54_02455	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G4P54_02465	COG1960	acyl-CoA dehydrogenase activity
G4P54_02480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G4P54_02485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_02490	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4P54_02495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4P54_02505	COG0513	Belongs to the DEAD box helicase family
G4P54_02510	COG3402	PFAM membrane-flanked domain
G4P54_02515	COG3428	Bacterial PH domain
G4P54_02520	COG0705	Rhomboid family
G4P54_02525	COG0736	holo-[acyl-carrier-protein] synthase activity
G4P54_02530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G4P54_02535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4P54_02540	COG0864	Transcriptional regulator
G4P54_02545	COG2337	Toxic component of a toxin-antitoxin (TA) module
G4P54_02550	COG1366	Belongs to the anti-sigma-factor antagonist family
G4P54_02555	COG1366	Belongs to the anti-sigma-factor antagonist family
G4P54_02560	COG2172	sigma factor antagonist activity
G4P54_02565	COG2208	phosphoserine phosphatase activity
G4P54_02570	COG1366	Belongs to the anti-sigma-factor antagonist family
G4P54_02575	COG2172	sigma factor antagonist activity
G4P54_02580	COG1191	sigma factor activity
G4P54_02585	COG2208	phosphoserine phosphatase activity
G4P54_02590	COG2183	response to ionizing radiation
G4P54_02600	COG3091	SprT-like family
G4P54_02640	COG0582	viral genome integration into host DNA
G4P54_02650	COG0582	viral genome integration into host DNA
G4P54_02660	COG1396	sequence-specific DNA binding
G4P54_02675	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4P54_02680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4P54_02690	COG3764	Sortase (surface protein transpeptidase)
G4P54_02700	COG0662	Cupin 2, conserved barrel domain protein
G4P54_02710	COG0477	Major facilitator Superfamily
G4P54_02740	COG2409	Drug exporters of the RND superfamily
G4P54_02745	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
G4P54_02765	COG1764	response to oxidative stress
G4P54_02770	COG1846	Transcriptional regulator
G4P54_02790	COG0251	oxidation-reduction process
G4P54_02795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4P54_02810	COG3239	Fatty acid desaturase
G4P54_02815	COG1278	Cold shock
G4P54_02820	COG1329	Transcriptional regulator
G4P54_02840	COG1733	regulation of RNA biosynthetic process
G4P54_02845	COG1278	Cold shock
G4P54_02850	COG0456	acetyltransferase
G4P54_02860	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
G4P54_02870	COG2273	Hydrolase Family 16
G4P54_02885	COG2030	dehydratase
G4P54_02890	COG3545	Serine hydrolase
G4P54_02895	COG1733	regulation of RNA biosynthetic process
G4P54_02900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4P54_02905	COG1733	regulation of RNA biosynthetic process
G4P54_02910	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4P54_02915	COG2814	Major facilitator Superfamily
G4P54_02920	COG1309	transcriptional regulator
G4P54_02930	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G4P54_02940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4P54_02945	COG0697	spore germination
G4P54_02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4P54_02955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4P54_02960	COG0640	Transcriptional regulator
G4P54_02980	COG4585	Histidine kinase
G4P54_02985	COG2197	response regulator
G4P54_02995	COG0596	Alpha beta hydrolase
G4P54_03000	COG1811	Na channel or pump
G4P54_03005	COG4978	Transcriptional regulator
G4P54_03005	COG0789	Transcriptional regulator
G4P54_03010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G4P54_03015	COG0778	Nitroreductase
G4P54_03020	COG0346	lactoylglutathione lyase activity
G4P54_03025	COG2259	Doxx family
G4P54_03030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_03045	COG2323	membrane
G4P54_03050	COG2323	membrane
G4P54_03055	COG0071	Belongs to the small heat shock protein (HSP20) family
G4P54_03075	COG1113	amino acid transport
G4P54_03080	COG2318	DinB family
G4P54_03085	COG1846	Transcriptional regulator
G4P54_03090	COG2409	Drug exporters of the RND superfamily
G4P54_03090	COG1033	growth of symbiont in host cell
G4P54_03100	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_03105	COG0778	Nitroreductase
G4P54_03110	COG1846	Transcriptional regulator
G4P54_03120	COG2814	Major facilitator Superfamily
G4P54_03125	COG0730	response to heat
G4P54_03130	COG1802	Transcriptional regulator
G4P54_03135	COG3858	chitin binding
G4P54_03135	COG1388	LysM domain
G4P54_03140	COG1819	glycosyl
G4P54_03150	COG1785	Belongs to the alkaline phosphatase family
G4P54_03160	COG1078	dGTPase activity
G4P54_03165	COG1388	LysM domain
G4P54_03170	COG2814	Major facilitator Superfamily
G4P54_03175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4P54_03180	COG1447	Phosphotransferase system cellobiose-specific component IIA
G4P54_03185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4P54_03190	COG2723	6-phospho-beta-galactosidase activity
G4P54_03195	COG2188	Transcriptional regulator
G4P54_03200	COG1940	carbohydrate kinase activity
G4P54_03205	COG1482	cell wall glycoprotein biosynthetic process
G4P54_03255	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G4P54_03260	COG0802	atpase or kinase
G4P54_03265	COG1214	PFAM Peptidase M22, glycoprotease
G4P54_03270	COG0456	acetyltransferase
G4P54_03275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G4P54_03280	COG0488	(ABC) transporter
G4P54_03285	COG0315	cyclic pyranopterin monophosphate synthase activity
G4P54_03290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G4P54_03295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4P54_03300	COG0805	protein transport
G4P54_03310	COG1266	CAAX protease self-immunity
G4P54_03320	COG0459	protein refolding
G4P54_03330	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_03345	COG1063	alcohol dehydrogenase
G4P54_03350	COG2211	Major facilitator Superfamily
G4P54_03355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4P54_03360	COG1842	Phage shock protein A
G4P54_03365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4P54_03370	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G4P54_03375	COG4260	virion core protein, lumpy skin disease virus
G4P54_03385	COG1063	alcohol dehydrogenase
G4P54_03390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G4P54_03395	COG0823	Involved in the tonB-independent uptake of proteins
G4P54_03410	COG2267	carboxylic ester hydrolase activity
G4P54_03420	COG2132	Multicopper oxidase
G4P54_03425	COG1113	amino acid transport
G4P54_03430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G4P54_03435	COG0714	Associated with various cellular activities
G4P54_03440	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
G4P54_03445	COG1305	Transglutaminase-like
G4P54_03465	COG2252	PERMEase
G4P54_03470	COG3064	Membrane
G4P54_03480	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
G4P54_03490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G4P54_03495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G4P54_03500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4P54_03505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G4P54_03510	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4P54_03515	COG0047	phosphoribosylformylglycinamidine synthase activity
G4P54_03520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4P54_03525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G4P54_03530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G4P54_03535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4P54_03540	COG0138	bifunctional purine biosynthesis protein purh
G4P54_03545	COG0151	Belongs to the GarS family
G4P54_03550	COG1522	sequence-specific DNA binding
G4P54_03555	COG0531	amino acid
G4P54_03565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G4P54_03570	COG1470	cell adhesion involved in biofilm formation
G4P54_03575	COG4496	protein, YerC YecD
G4P54_03585	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
G4P54_03590	COG0210	DNA helicase
G4P54_03595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4P54_03600	COG4851	CamS sex pheromone cAM373 precursor
G4P54_03605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4P54_03610	COG1285	pathogenesis
G4P54_03615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4P54_03620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4P54_03625	COG0154	amidase activity
G4P54_03630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4P54_03635	COG1309	transcriptional regulator
G4P54_03640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4P54_03650	COG1597	lipid kinase activity
G4P54_03655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4P54_03680	COG0457	Tetratricopeptide repeat
G4P54_03710	COG5444	nuclease activity
G4P54_03720	COG0457	Tetratricopeptide repeat
G4P54_03730	COG0217	transcriptional regulatory protein
G4P54_03740	COG1309	transcriptional regulator
G4P54_03745	COG3631	Ketosteroid isomerase-related protein
G4P54_03750	COG0702	epimerase
G4P54_03755	COG2159	amidohydrolase
G4P54_03775	COG3546	catalase activity
G4P54_03780	COG0454	-acetyltransferase
G4P54_03790	COG2323	membrane
G4P54_03795	COG2329	Antibiotic biosynthesis monooxygenase
G4P54_03800	COG0346	lactoylglutathione lyase activity
G4P54_03810	COG1366	Belongs to the anti-sigma-factor antagonist family
G4P54_03815	COG5583	Uncharacterized small protein (DUF2292)
G4P54_03820	COG0670	Belongs to the BI1 family
G4P54_03835	COG1368	sulfuric ester hydrolase activity
G4P54_03840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G4P54_03845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4P54_03850	COG1442	glycosyl transferase family 8
G4P54_03855	COG1216	Glycosyl transferase, family 2
G4P54_03860	COG1442	glycosyl transferase family 8
G4P54_03865	COG2223	nitrite transmembrane transporter activity
G4P54_03870	COG1011	Hydrolase
G4P54_03875	COG0531	amino acid
G4P54_03880	COG1012	belongs to the aldehyde dehydrogenase family
G4P54_03885	COG0840	transmembrane signaling receptor activity
G4P54_03890	COG0488	(ABC) transporter
G4P54_03900	COG0789	Transcriptional regulator
G4P54_03905	COG2814	Major facilitator Superfamily
G4P54_03915	COG0488	(ABC) transporter
G4P54_03920	COG0513	Belongs to the DEAD box helicase family
G4P54_03925	COG0456	acetyltransferase
G4P54_03930	COG2130	NADP-dependent
G4P54_03935	COG1120	ATPase activity
G4P54_03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_03945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_03950	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
G4P54_03965	COG3866	Pectate lyase
G4P54_03970	COG0471	metal ion transport
G4P54_03975	COG3290	protein histidine kinase activity
G4P54_03980	COG4565	transcriptional regulatory protein
G4P54_03985	COG3181	Tripartite tricarboxylate transporter family receptor
G4P54_03990	COG2851	Citrate transporter
G4P54_03995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4P54_04000	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
G4P54_04005	COG1254	Belongs to the acylphosphatase family
G4P54_04010	COG2258	MOSC domain
G4P54_04030	COG0024	Methionine aminopeptidase
G4P54_04035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_04035	COG1263	PTS System
G4P54_04040	COG1368	sulfuric ester hydrolase activity
G4P54_04050	COG1115	amino acid carrier protein
G4P54_04055	COG0531	amino acid
G4P54_04070	COG0697	spore germination
G4P54_04075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_04075	COG1263	PTS System
G4P54_04080	COG0366	Alpha amylase catalytic
G4P54_04085	COG2188	Transcriptional regulator
G4P54_04090	COG0778	Nitroreductase
G4P54_04095	COG0737	Belongs to the 5'-nucleotidase family
G4P54_04100	COG0693	protein deglycase activity
G4P54_04105	COG2814	Major facilitator Superfamily
G4P54_04110	COG4840	Belongs to the UPF0435 family
G4P54_04115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4P54_04120	COG4980	gas vesicle protein
G4P54_04125	COG1295	ribonuclease BN
G4P54_04130	COG0477	Major facilitator Superfamily
G4P54_04135	COG0387	Pfam Sodium calcium exchanger
G4P54_04145	COG0668	transmembrane transport
G4P54_04150	COG0535	radical SAM domain protein
G4P54_04160	COG0726	polysaccharide deacetylase
G4P54_04185	COG2084	Dehydrogenase
G4P54_04190	COG0598	Magnesium transport protein CorA
G4P54_04195	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G4P54_04205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4P54_04210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4P54_04215	COG4637	Psort location Cytoplasmic, score
G4P54_04225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4P54_04230	COG0022	dehydrogenase e1 component
G4P54_04235	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4P54_04240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4P54_04245	COG3284	Transcriptional regulator
G4P54_04255	COG1742	UPF0060 membrane protein
G4P54_04275	COG4842	Belongs to the WXG100 family
G4P54_04290	COG5444	nuclease activity
G4P54_04305	COG1486	melibiose metabolic process
G4P54_04310	COG1737	Transcriptional regulator
G4P54_04315	COG1263	PTS System
G4P54_04315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_04320	COG1132	(ABC) transporter
G4P54_04325	COG1132	(ABC) transporter
G4P54_04330	COG2259	Doxx family
G4P54_04335	COG2514	catechol 2,3-dioxygenase activity
G4P54_04340	COG4585	Histidine kinase
G4P54_04345	COG2197	response regulator
G4P54_04350	COG1131	(ABC) transporter
G4P54_04355	COG1511	domain protein
G4P54_04355	COG0842	Transport permease protein
G4P54_04360	COG0842	Transport permease protein
G4P54_04370	COG1695	Transcriptional regulator
G4P54_04380	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
G4P54_04385	COG1309	transcriptional regulator
G4P54_04390	COG2814	Major facilitator Superfamily
G4P54_04395	COG2318	DinB family
G4P54_04400	COG2814	Major facilitator Superfamily
G4P54_04405	COG1846	Transcriptional regulator
G4P54_04410	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G4P54_04410	COG0392	lysyltransferase activity
G4P54_04415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4P54_04420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_04425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_04430	COG0384	phenazine biosynthesis protein PhzF
G4P54_04435	COG0778	Nitroreductase
G4P54_04450	COG1090	epimerase
G4P54_04455	COG2137	regulation of response to DNA damage stimulus
G4P54_04465	COG2814	Major facilitator Superfamily
G4P54_04480	COG3103	Sh3 type 3 domain protein
G4P54_04485	COG5658	integral membrane protein
G4P54_04490	COG0596	Alpha beta hydrolase
G4P54_04495	COG0463	Glycosyl transferase, family 2
G4P54_04500	COG4485	Bacterial membrane protein, YfhO
G4P54_04505	COG1988	membrane-bound metal-dependent
G4P54_04510	COG1194	a g-specific adenine glycosylase
G4P54_04520	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_04535	COG3557	Belongs to the UPF0374 family
G4P54_04540	COG1132	(ABC) transporter
G4P54_04545	COG4129	membrane
G4P54_04550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G4P54_04555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4P54_04560	COG0735	belongs to the Fur family
G4P54_04670	COG4326	sporulation control protein
G4P54_04680	COG5577	PFAM Coat F domain
G4P54_04685	COG3340	Belongs to the peptidase S51 family
G4P54_04690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G4P54_04700	COG0753	catalase activity
G4P54_04705	COG1116	anion transmembrane transporter activity
G4P54_04710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4P54_04715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4P54_04720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4P54_04730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G4P54_04740	COG1476	TRANSCRIPTIONal
G4P54_04750	COG3382	B3 4 domain protein
G4P54_04755	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4P54_04765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G4P54_04770	COG0789	Transcriptional regulator
G4P54_04775	COG1664	Polymer-forming cytoskeletal
G4P54_04780	COG1664	Polymer-forming cytoskeletal
G4P54_04785	COG2766	serine protein kinase
G4P54_04790	COG2718	Belongs to the UPF0229 family
G4P54_04795	COG1846	Transcriptional regulator
G4P54_04800	COG1566	PFAM secretion protein HlyD family protein
G4P54_04805	COG2814	Major facilitator Superfamily
G4P54_04810	COG0655	NAD(P)H dehydrogenase (quinone) activity
G4P54_04830	COG1725	Transcriptional regulator
G4P54_04835	COG1131	(ABC) transporter
G4P54_04840	COG1131	(ABC) transporter
G4P54_04845	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G4P54_04850	COG1278	Cold shock
G4P54_04855	COG1464	Belongs to the NlpA lipoprotein family
G4P54_04860	COG3706	GGDEF domain
G4P54_04865	COG1823	symporter activity
G4P54_04900	COG5577	PFAM Coat F domain
G4P54_04905	COG3764	Sortase (surface protein transpeptidase)
G4P54_04910	COG0564	pseudouridine synthase activity
G4P54_04920	COG0517	IMP dehydrogenase activity
G4P54_04925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4P54_04930	COG3153	acetyltransferase
G4P54_04930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4P54_04935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4P54_04940	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
G4P54_04945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4P54_04950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4P54_04955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G4P54_04960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4P54_04965	COG4585	Histidine kinase
G4P54_04965	COG2203	Gaf domain
G4P54_04970	COG2197	response regulator
G4P54_04990	COG0791	NLP P60 protein
G4P54_04990	COG1388	LysM domain
G4P54_04995	COG1959	2 iron, 2 sulfur cluster binding
G4P54_05000	COG0668	transmembrane transport
G4P54_05005	COG2719	SpoVR family
G4P54_05010	COG1785	Belongs to the alkaline phosphatase family
G4P54_05015	COG0791	NLP P60 protein
G4P54_05015	COG1388	LysM domain
G4P54_05020	COG0583	DNA-binding transcription factor activity
G4P54_05025	COG0372	Belongs to the citrate synthase family
G4P54_05030	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_05035	COG0531	amino acid
G4P54_05040	COG0733	neurotransmitter:sodium symporter activity
G4P54_05045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4P54_05050	COG0456	acetyltransferase
G4P54_05065	COG1595	DNA-templated transcription, initiation
G4P54_05070	COG0667	Aldo Keto reductase
G4P54_05075	COG0204	Acyl-transferase
G4P54_05085	COG1253	flavin adenine dinucleotide binding
G4P54_05090	COG0789	Transcriptional regulator
G4P54_05095	COG0436	Aminotransferase
G4P54_05100	COG1253	flavin adenine dinucleotide binding
G4P54_05105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4P54_05110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4P54_05115	COG0584	glycerophosphoryl diester phosphodiesterase
G4P54_05125	COG0668	transmembrane transport
G4P54_05130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G4P54_05135	COG0726	polysaccharide deacetylase
G4P54_05140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4P54_05145	COG1757	Na H antiporter
G4P54_05150	COG0589	response to stress
G4P54_05155	COG1132	(ABC) transporter
G4P54_05160	COG1132	(ABC) transporter
G4P54_05165	COG0702	epimerase
G4P54_05185	COG0189	ligase activity
G4P54_05190	COG0189	ligase activity
G4P54_05195	COG4399	Belongs to the UPF0754 family
G4P54_05205	COG4335	DNA alkylation repair
G4P54_05210	COG0561	phosphatase activity
G4P54_05215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4P54_05220	COG0475	glutathione-regulated potassium exporter activity
G4P54_05225	COG0490	domain, Protein
G4P54_05235	COG1024	Enoyl-CoA hydratase
G4P54_05245	COG4152	abc transporter atp-binding protein
G4P54_05250	COG1668	transmembrane transport
G4P54_05255	COG0420	3'-5' exonuclease activity
G4P54_05260	COG4717	serine-type aminopeptidase activity
G4P54_05265	COG3481	metal-dependent phosphohydrolase, HD sub domain
G4P54_05275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4P54_05305	COG1846	Transcriptional regulator
G4P54_05310	COG4980	gas vesicle protein
G4P54_05325	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G4P54_05330	COG0537	adenosine 5'-monophosphoramidase activity
G4P54_05335	COG1131	(ABC) transporter
G4P54_05340	COG4473	ABC transporter
G4P54_05350	COG1473	amidohydrolase
G4P54_05355	COG3069	C4-dicarboxylate transmembrane transporter activity
G4P54_05365	COG2329	Antibiotic biosynthesis monooxygenase
G4P54_05370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4P54_05375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G4P54_05390	COG1309	transcriptional regulator
G4P54_05395	COG1511	domain protein
G4P54_05400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4P54_05405	COG4377	Putative membrane peptidase family (DUF2324)
G4P54_05415	COG1363	Peptidase, m42
G4P54_05420	COG4405	Protein conserved in bacteria
G4P54_05425	COG1301	dicarboxylic acid transport
G4P54_05435	COG1234	tRNA 3'-trailer cleavage
G4P54_05440	COG0095	Lipoate-protein ligase
G4P54_05445	COG0702	epimerase
G4P54_05450	COG0318	PFAM AMP-dependent synthetase and ligase
G4P54_05460	COG0501	Belongs to the peptidase M48B family
G4P54_05470	COG0456	acetyltransferase
G4P54_05475	COG0604	alcohol dehydrogenase
G4P54_05480	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
G4P54_05485	COG0406	alpha-ribazole phosphatase activity
G4P54_05490	COG0183	Belongs to the thiolase family
G4P54_05495	COG0318	PFAM AMP-dependent synthetase and ligase
G4P54_05500	COG1268	BioY protein
G4P54_05505	COG0840	transmembrane signaling receptor activity
G4P54_05510	COG0723	plastoquinol--plastocyanin reductase activity
G4P54_05510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4P54_05515	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_05525	COG4903	ComK protein
G4P54_05530	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_05540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4P54_05555	COG0398	Pfam SNARE associated Golgi protein
G4P54_05560	COG0681	Belongs to the peptidase S26 family
G4P54_05565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4P54_05570	COG1846	Transcriptional regulator
G4P54_05580	COG0738	Major facilitator superfamily
G4P54_05585	COG0673	inositol 2-dehydrogenase activity
G4P54_05590	COG0561	phosphatase activity
G4P54_05595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4P54_05600	COG1609	Transcriptional regulator
G4P54_05605	COG3180	Ammonia monooxygenase
G4P54_05610	COG0477	Major facilitator Superfamily
G4P54_05610	COG2814	Major facilitator Superfamily
G4P54_05615	COG4533	DNA binding
G4P54_05625	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
G4P54_05630	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
G4P54_05635	COG1074	ATP-dependent DNA helicase activity
G4P54_05640	COG0420	3'-5' exonuclease activity
G4P54_05645	COG0419	ATPase involved in DNA repair
G4P54_05650	COG1403	HNH endonuclease
G4P54_05690	COG5337	Spore coat protein CotH
G4P54_05695	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4P54_05705	COG1404	Belongs to the peptidase S8 family
G4P54_05715	COG0367	asparagine synthase
G4P54_05720	COG2318	DinB family
G4P54_05725	COG1562	ergosterol biosynthetic process
G4P54_05730	COG0534	Mate efflux family protein
G4P54_05735	COG2207	Transcriptional regulator
G4P54_05735	COG1917	Cupin 2, conserved barrel domain protein
G4P54_05745	COG2318	DinB family
G4P54_05750	COG1279	arginine transmembrane transporter activity
G4P54_05755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4P54_05760	COG1357	PFAM Pentapeptide repeats (8 copies)
G4P54_05765	COG2267	carboxylic ester hydrolase activity
G4P54_05770	COG0529	Catalyzes the synthesis of activated sulfate
G4P54_05775	COG2046	Belongs to the sulfate adenylyltransferase family
G4P54_05780	COG0175	sulfate reduction
G4P54_05785	COG2045	Belongs to the ComB family
G4P54_05790	COG1809	phosphosulfolactate synthase activity
G4P54_05795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4P54_05800	COG4948	Mandelate Racemase Muconate Lactonizing
G4P54_05805	COG2814	Major facilitator Superfamily
G4P54_05810	COG0454	-acetyltransferase
G4P54_05815	COG2153	protein acetylation
G4P54_05820	COG0646	methionine synthase
G4P54_05820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G4P54_05825	COG1666	GTP binding
G4P54_05830	COG2996	Protein conserved in bacteria
G4P54_05840	COG1307	EDD domain protein, DegV family
G4P54_05845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4P54_05860	COG0561	phosphatase activity
G4P54_05865	COG1073	alpha beta
G4P54_05870	COG2151	metal-sulfur cluster biosynthetic enzyme
G4P54_05880	COG0277	FAD linked oxidase domain protein
G4P54_05885	COG2271	Major facilitator Superfamily
G4P54_05890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G4P54_05895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G4P54_05905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4P54_05910	COG0505	Belongs to the CarA family
G4P54_05915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4P54_05920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4P54_05935	COG2267	carboxylic ester hydrolase activity
G4P54_05945	COG1744	ABC transporter substrate-binding protein PnrA-like
G4P54_05960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4P54_05965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4P54_05970	COG5504	Zn-dependent protease
G4P54_05975	COG0444	Belongs to the ABC transporter superfamily
G4P54_05980	COG4608	Belongs to the ABC transporter superfamily
G4P54_05990	COG0601	transmembrane transport
G4P54_05995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4P54_06005	COG0180	Tryptophanyl-tRNA synthetase
G4P54_06010	COG4166	transmembrane transport
G4P54_06015	COG0601	transmembrane transport
G4P54_06020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4P54_06025	COG0444	Belongs to the ABC transporter superfamily
G4P54_06030	COG4608	Belongs to the ABC transporter superfamily
G4P54_06035	COG2814	Major facilitator Superfamily
G4P54_06040	COG0456	acetyltransferase
G4P54_06045	COG1393	Belongs to the ArsC family
G4P54_06050	COG0861	Integral membrane protein TerC family
G4P54_06060	COG4862	establishment of competence for transformation
G4P54_06065	COG4469	Competence protein
G4P54_06070	COG1164	Oligoendopeptidase f
G4P54_06085	COG2346	COG2346, Truncated hemoglobins
G4P54_06090	COG0741	lytic transglycosylase activity
G4P54_06095	COG4116	CYTH
G4P54_06105	COG2357	RelA SpoT domain protein
G4P54_06110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G4P54_06115	COG0564	pseudouridine synthase activity
G4P54_06120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4P54_06125	COG0475	glutathione-regulated potassium exporter activity
G4P54_06125	COG0569	domain protein
G4P54_06130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G4P54_06135	COG0352	thiamine-phosphate diphosphorylase activity
G4P54_06140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4P54_06145	COG2104	thiamine diphosphate biosynthetic process
G4P54_06150	COG2022	thiamine diphosphate biosynthetic process
G4P54_06155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4P54_06160	COG0351	phosphomethylpyrimidine kinase
G4P54_06165	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G4P54_06220	COG0210	DNA helicase
G4P54_06235	COG2153	protein acetylation
G4P54_06240	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G4P54_06245	COG2382	esterase
G4P54_06250	COG0626	cystathionine gamma-synthase activity
G4P54_06255	COG0626	cystathionine gamma-synthase activity
G4P54_06260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4P54_06265	COG5505	Protein of unknown function (DUF819)
G4P54_06285	COG5444	nuclease activity
G4P54_06305	COG1335	isochorismatase
G4P54_06320	COG5577	PFAM Coat F domain
G4P54_06330	COG1063	alcohol dehydrogenase
G4P54_06335	COG5577	PFAM Coat F domain
G4P54_06350	COG0457	Tetratricopeptide repeat
G4P54_06355	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
G4P54_06365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4P54_06390	COG0109	protoheme IX farnesyltransferase activity
G4P54_06400	COG0726	polysaccharide deacetylase
G4P54_06415	COG5504	Zn-dependent protease
G4P54_06420	COG2205	protein histidine kinase activity
G4P54_06430	COG3383	formate dehydrogenase (NAD+) activity
G4P54_06435	COG2427	Protein of unknown function (DUF1641)
G4P54_06445	COG1051	belongs to the nudix hydrolase family
G4P54_06455	COG2124	cytochrome p450
G4P54_06460	COG1819	glycosyl
G4P54_06470	COG1587	Uroporphyrinogen-III synthase
G4P54_06475	COG0390	transport system, permease component
G4P54_06480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4P54_06485	COG0697	spore germination
G4P54_06490	COG4297	protein containing double-stranded beta helix domain
G4P54_06500	COG1252	NADH dehydrogenase
G4P54_06510	COG0730	response to heat
G4P54_06515	COG2318	DinB family
G4P54_06520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4P54_06525	COG0457	Tetratricopeptide repeat
G4P54_06540	COG1388	LysM domain
G4P54_06540	COG5632	N-Acetylmuramoyl-L-alanine amidase
G4P54_06540	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_06550	COG4195	phage-related replication protein
G4P54_06560	COG2856	Zn peptidase
G4P54_06565	COG1396	sequence-specific DNA binding
G4P54_06575	COG1522	sequence-specific DNA binding
G4P54_06580	COG1484	DNA-dependent DNA replication
G4P54_06600	COG1595	DNA-templated transcription, initiation
G4P54_06605	COG3728	DNA packaging
G4P54_06605	COG5484	DNA packaging
G4P54_06610	COG1783	phage Terminase large subunit
G4P54_06615	COG5518	Phage portal protein
G4P54_06620	COG0338	D12 class N6 adenine-specific DNA methyltransferase
G4P54_06625	COG4653	Phage capsid family
G4P54_06675	COG3953	SLT domain
G4P54_06675	COG5412	phage tail tape measure protein
G4P54_06680	COG1652	LysM domain
G4P54_06685	COG4193	domain, Protein
G4P54_06695	COG3628	GPW Gp25 family protein
G4P54_06700	COG3299	homolog of phage Mu protein gp47
G4P54_06705	COG3778	Protein conserved in bacteria
G4P54_06740	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_06740	COG5632	N-Acetylmuramoyl-L-alanine amidase
G4P54_06745	COG3594	Acyltransferase
G4P54_06765	COG0306	phosphate transporter
G4P54_06770	COG1392	Phosphate transport regulator
G4P54_06775	COG0531	amino acid
G4P54_06780	COG0346	lactoylglutathione lyase activity
G4P54_06785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4P54_06790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4P54_06795	COG2362	D-Aminopeptidase
G4P54_06800	COG0601	transmembrane transport
G4P54_06805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4P54_06810	COG0444	Belongs to the ABC transporter superfamily
G4P54_06815	COG4166	transmembrane transport
G4P54_06820	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4P54_06825	COG4948	Mandelate Racemase Muconate Lactonizing
G4P54_06830	COG0791	NLP P60 protein
G4P54_06835	COG4608	Belongs to the ABC transporter superfamily
G4P54_06840	COG2706	6-phosphogluconolactonase activity
G4P54_06845	COG1834	amidinotransferase
G4P54_06850	COG1607	acyl-coa hydrolase
G4P54_06855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4P54_06855	COG1017	nitric oxide dioxygenase activity
G4P54_06865	COG2323	membrane
G4P54_06870	COG2318	DinB family
G4P54_06875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4P54_06880	COG2076	Multidrug Resistance protein
G4P54_06885	COG2076	Multidrug Resistance protein
G4P54_06890	COG0788	formyltetrahydrofolate deformylase activity
G4P54_06895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G4P54_06900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4P54_06910	COG1846	Transcriptional regulator
G4P54_06915	COG1764	response to oxidative stress
G4P54_06920	COG0463	Glycosyl transferase, family 2
G4P54_06920	COG0457	Tetratricopeptide repeat
G4P54_06925	COG0590	tRNA wobble adenosine to inosine editing
G4P54_06935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4P54_06940	COG1404	Belongs to the peptidase S8 family
G4P54_06945	COG1366	Belongs to the anti-sigma-factor antagonist family
G4P54_06950	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G4P54_06955	COG1122	ATPase activity
G4P54_06960	COG4721	ABC-type cobalt transport system, permease component
G4P54_06975	COG2239	Acts as a magnesium transporter
G4P54_06980	COG0789	Transcriptional regulator
G4P54_06995	COG1846	Transcriptional regulator
G4P54_07005	COG0726	polysaccharide deacetylase
G4P54_07010	COG1408	metallophosphoesterase
G4P54_07020	COG0463	Glycosyl transferase, family 2
G4P54_07025	COG3285	dna ligase
G4P54_07025	COG1793	dna ligase
G4P54_07030	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G4P54_07035	COG5001	Diguanylate cyclase
G4P54_07035	COG3300	MHYT domain
G4P54_07040	COG0586	Pfam SNARE associated Golgi protein
G4P54_07045	COG0861	Integral membrane protein TerC family
G4P54_07050	COG1191	sigma factor activity
G4P54_07070	COG0501	Belongs to the peptidase M48B family
G4P54_07075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G4P54_07090	COG3594	Acyltransferase
G4P54_07095	COG5002	protein histidine kinase activity
G4P54_07100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4P54_07110	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G4P54_07115	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
G4P54_07120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4P54_07125	COG0436	Aminotransferase
G4P54_07130	COG1850	ribulose-bisphosphate carboxylase activity
G4P54_07135	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
G4P54_07140	COG0235	Class ii aldolase
G4P54_07145	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
G4P54_07150	COG3339	Conserved Protein
G4P54_07165	COG3852	Histidine kinase
G4P54_07170	COG1846	Transcriptional regulator
G4P54_07175	COG1360	Flagellar Motor Protein
G4P54_07180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4P54_07185	COG0542	response to heat
G4P54_07190	COG3949	Membrane
G4P54_07195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G4P54_07200	COG0720	synthase
G4P54_07205	COG0602	queuosine metabolic process
G4P54_07210	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G4P54_07220	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_07235	COG4873	Protein conserved in bacteria
G4P54_07245	COG3773	Cell wall hydrolase
G4P54_07250	COG2244	polysaccharide biosynthetic process
G4P54_07255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_07260	COG2217	Heavy metal translocating P-type atpase
G4P54_07270	COG0006	proline dipeptidase activity
G4P54_07275	COG1609	Transcriptional regulator
G4P54_07280	COG3711	transcriptional antiterminator
G4P54_07285	COG2190	(PTS) system
G4P54_07285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_07285	COG1263	PTS System
G4P54_07290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4P54_07295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4P54_07305	COG1533	DNA photolyase activity
G4P54_07315	COG0840	transmembrane signaling receptor activity
G4P54_07320	COG2084	Dehydrogenase
G4P54_07325	COG2340	Cysteine-rich secretory protein family
G4P54_07330	COG0768	penicillin binding
G4P54_07335	COG4191	Histidine kinase
G4P54_07340	COG0436	Aminotransferase
G4P54_07350	COG0835	chemotaxis
G4P54_07350	COG0784	Response regulator, receiver
G4P54_07360	COG2814	Major facilitator Superfamily
G4P54_07365	COG1376	ErfK ybiS ycfS ynhG family protein
G4P54_07370	COG1408	metallophosphoesterase
G4P54_07375	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_07380	COG2200	EAL domain
G4P54_07385	COG4703	Protein of unknown function (DUF1797)
G4P54_07390	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
G4P54_07400	COG0517	IMP dehydrogenase activity
G4P54_07405	COG0583	DNA-binding transcription factor activity
G4P54_07410	COG0716	FMN binding
G4P54_07420	COG0716	FMN binding
G4P54_07425	COG2171	N-acyltransferase activity
G4P54_07430	COG1473	amidohydrolase
G4P54_07440	COG0668	transmembrane transport
G4P54_07445	COG0450	alkyl hydroperoxide reductase
G4P54_07450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_07465	COG0746	molybdenum cofactor guanylyltransferase activity
G4P54_07470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4P54_07475	COG0303	'Molybdopterin
G4P54_07480	COG1763	Mo-molybdopterin cofactor biosynthetic process
G4P54_07485	COG0314	molybdopterin synthase activity
G4P54_07490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G4P54_07495	COG1132	(ABC) transporter
G4P54_07500	COG1132	(ABC) transporter
G4P54_07510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4P54_07515	COG1136	(ABC) transporter
G4P54_07520	COG0577	efflux transmembrane transporter activity
G4P54_07525	COG1349	DNA-binding transcription factor activity
G4P54_07530	COG1105	Belongs to the carbohydrate kinase PfkB family
G4P54_07535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4P54_07535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4P54_07535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4P54_07540	COG0681	Belongs to the peptidase S26 family
G4P54_07550	COG0488	(ABC) transporter
G4P54_07555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G4P54_07560	COG2309	aminopeptidase activity
G4P54_07570	COG1077	Cell shape determining protein MreB Mrl
G4P54_07575	COG2002	toxin-antitoxin pair type II binding
G4P54_07580	COG3852	Histidine kinase
G4P54_07585	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G4P54_07585	COG2105	PFAM AIG2 family protein
G4P54_07590	COG0569	domain protein
G4P54_07595	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G4P54_07600	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G4P54_07610	COG0561	phosphatase activity
G4P54_07615	COG0242	peptide deformylase activity
G4P54_07625	COG0497	DNA recombination
G4P54_07630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4P54_07635	COG0022	dehydrogenase e1 component
G4P54_07640	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4P54_07645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4P54_07650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_07660	COG1982	Orn Lys Arg decarboxylase major
G4P54_07665	COG4476	Belongs to the UPF0223 family
G4P54_07670	COG4493	Belongs to the UPF0637 family
G4P54_07680	COG0483	inositol monophosphate 1-phosphatase activity
G4P54_07690	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G4P54_07710	COG1595	DNA-templated transcription, initiation
G4P54_07750	COG4896	Protein conserved in bacteria
G4P54_07760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G4P54_07765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4P54_07770	COG2066	Belongs to the glutaminase family
G4P54_07775	COG4838	Belongs to the UPF0358 family
G4P54_07780	COG0772	Belongs to the SEDS family
G4P54_07785	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G4P54_07790	COG1612	heme a metabolic process
G4P54_07795	COG0109	protoheme IX farnesyltransferase activity
G4P54_07800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4P54_07800	COG2010	Cytochrome c
G4P54_07805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4P54_07810	COG1845	cytochrome c oxidase, subunit III
G4P54_07815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G4P54_07820	COG3336	cytochrome c oxidase
G4P54_07830	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
G4P54_07835	COG2340	Cysteine-rich secretory protein family
G4P54_07850	COG3679	Belongs to the UPF0342 family
G4P54_07855	COG4471	UPF0298 protein
G4P54_07860	COG0742	ribosomal rna small subunit methyltransferase
G4P54_07865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G4P54_07870	COG3314	Sporulation integral membrane protein YlbJ
G4P54_07875	COG1752	Esterase of the alpha-beta hydrolase superfamily
G4P54_07880	COG3480	Lon protease (S16) C-terminal proteolytic domain
G4P54_07885	COG1323	Belongs to the UPF0348 family
G4P54_07890	COG1399	metal-binding, possibly nucleic acid-binding protein
G4P54_07905	COG0454	-acetyltransferase
G4P54_07910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G4P54_07915	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
G4P54_07920	COG2001	Belongs to the MraZ family
G4P54_07925	COG0275	rRNA processing
G4P54_07930	COG4839	cell division protein FtsL
G4P54_07940	COG0768	penicillin binding
G4P54_07945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4P54_07950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4P54_07955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4P54_07960	COG0772	Belongs to the SEDS family
G4P54_07965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4P54_07970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4P54_07975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G4P54_07980	COG3879	Bacterial protein of unknown function (DUF881)
G4P54_07985	COG3879	Bacterial protein of unknown function (DUF881)
G4P54_07990	COG3856	small basic protein
G4P54_07995	COG0849	cell division
G4P54_08000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4P54_08005	COG1404	Belongs to the peptidase S8 family
G4P54_08005	COG4412	M6 family metalloprotease domain protein
G4P54_08015	COG1191	sigma factor activity
G4P54_08020	COG1191	sigma factor activity
G4P54_08025	COG1119	ATPase activity
G4P54_08030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4P54_08035	COG1873	PFAM PRC-barrel domain
G4P54_08045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G4P54_08050	COG1799	cell septum assembly
G4P54_08055	COG0762	integral membrane protein
G4P54_08060	COG2302	S4 RNA-binding domain
G4P54_08065	COG3599	regulation of cell shape
G4P54_08070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G4P54_08075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4P54_08080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G4P54_08085	COG0564	pseudouridine synthase activity
G4P54_08090	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G4P54_08095	COG2233	PERMEase
G4P54_08100	COG0540	Belongs to the ATCase OTCase family
G4P54_08105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4P54_08110	COG0505	Belongs to the CarA family
G4P54_08115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4P54_08120	COG0543	2 iron, 2 sulfur cluster binding
G4P54_08125	COG0167	dihydroorotate dehydrogenase activity
G4P54_08130	COG0284	orotidine-5'-phosphate decarboxylase activity
G4P54_08135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G4P54_08140	COG0175	sulfate reduction
G4P54_08145	COG0306	phosphate transporter
G4P54_08150	COG2046	Belongs to the sulfate adenylyltransferase family
G4P54_08155	COG0529	Catalyzes the synthesis of activated sulfate
G4P54_08160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4P54_08165	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
G4P54_08170	COG1648	precorrin-2 dehydrogenase activity
G4P54_08175	COG1293	RNA-binding protein homologous to eukaryotic snRNP
G4P54_08180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4P54_08185	COG1561	YicC-like family, N-terminal region
G4P54_08195	COG0194	GDP metabolic process
G4P54_08200	COG1758	RNA polymerase activity
G4P54_08205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4P54_08210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4P54_08215	COG0242	peptide deformylase activity
G4P54_08220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4P54_08225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4P54_08225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4P54_08230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G4P54_08235	COG0631	protein serine/threonine phosphatase activity
G4P54_08240	COG2815	serine threonine protein kinase
G4P54_08240	COG0515	serine threonine protein kinase
G4P54_08245	COG1162	GTPase activity
G4P54_08250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4P54_08255	COG1564	THIamine pyrophosphokinase
G4P54_08265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4P54_08270	COG1302	Protein conserved in bacteria
G4P54_08275	COG1461	Dihydroxyacetone kinase
G4P54_08280	COG1760	l-serine dehydratase
G4P54_08285	COG1760	l-serine dehydratase
G4P54_08290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4P54_08295	COG2050	protein possibly involved in aromatic compounds catabolism
G4P54_08295	COG1349	DNA-binding transcription factor activity
G4P54_08300	COG0416	fatty acid biosynthetic process
G4P54_08305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4P54_08310	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_08320	COG0571	ribonuclease III activity
G4P54_08325	COG1196	nuclear chromosome segregation
G4P54_08330	COG0552	protein localization to endoplasmic reticulum
G4P54_08340	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
G4P54_08345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4P54_08350	COG0228	four-way junction DNA binding
G4P54_08355	COG1837	Belongs to the UPF0109 family
G4P54_08365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4P54_08370	COG0336	Belongs to the RNA methyltransferase TrmD family
G4P54_08375	COG0335	large ribosomal subunit rRNA binding
G4P54_08385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4P54_08395	COG2257	FlhB HrpN YscU SpaS Family
G4P54_08400	COG0045	succinate-CoA ligase (ADP-forming) activity
G4P54_08405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4P54_08410	COG0758	DNA mediated transformation
G4P54_08415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4P54_08420	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
G4P54_08425	COG4974	Belongs to the 'phage' integrase family
G4P54_08430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G4P54_08435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G4P54_08440	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
G4P54_08445	COG1815	bacterial-type flagellum-dependent cell motility
G4P54_08450	COG1558	bacterial-type flagellum-dependent cell motility
G4P54_08455	COG1677	Flagellar hook-basal body complex protein FliE
G4P54_08460	COG1766	The M ring may be actively involved in energy transduction
G4P54_08465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4P54_08470	COG1317	bacterial-type flagellum organization
G4P54_08475	COG1157	protein secretion by the type III secretion system
G4P54_08480	COG2882	bacterial-type flagellum organization
G4P54_08485	COG3334	PFAM MgtE intracellular
G4P54_08490	COG3144	bacterial-type flagellum assembly
G4P54_08495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G4P54_08500	COG4786	Flagellar basal body rod
G4P54_08505	COG1582	Flagellar protein (FlbD)
G4P54_08510	COG1580	Controls the rotational direction of flagella during chemotaxis
G4P54_08515	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4P54_08520	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4P54_08520	COG1776	CheC inhibitor of MCP methylation
G4P54_08525	COG2201	protein-glutamate methylesterase activity
G4P54_08530	COG3190	flagellar
G4P54_08535	COG1338	Plays a role in the flagellum-specific transport system
G4P54_08540	COG1987	bacterial-type flagellum assembly
G4P54_08545	COG1684	flagellar biosynthetic protein fliR
G4P54_08550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4P54_08555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4P54_08560	COG1419	protein localization to endoplasmic reticulum
G4P54_08565	COG0455	bacterial-type flagellum organization
G4P54_08570	COG2201	protein-glutamate methylesterase activity
G4P54_08575	COG0643	Histidine kinase
G4P54_08575	COG2198	Histidine kinase
G4P54_08580	COG0835	chemotaxis
G4P54_08585	COG1776	CheC inhibitor of MCP methylation
G4P54_08590	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G4P54_08595	COG1191	sigma factor activity
G4P54_08605	COG0052	Belongs to the universal ribosomal protein uS2 family
G4P54_08610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G4P54_08615	COG0528	UMP kinase activity
G4P54_08620	COG0233	cytoplasmic translational termination
G4P54_08625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4P54_08630	COG4589	Belongs to the CDS family
G4P54_08635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4P54_08640	COG0750	zinc metalloprotease
G4P54_08645	COG0442	prolyl-tRNA aminoacylation
G4P54_08650	COG2176	DNA-directed DNA polymerase activity
G4P54_08655	COG0779	Required for maturation of 30S ribosomal subunits
G4P54_08660	COG0195	Participates in both transcription termination and antitermination
G4P54_08665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G4P54_08670	COG1358	cellular component organization or biogenesis
G4P54_08675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G4P54_08680	COG1550	Protein conserved in bacteria
G4P54_08685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G4P54_08690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G4P54_08695	COG0196	riboflavin kinase activity
G4P54_08705	COG1185	polyribonucleotide nucleotidyltransferase activity
G4P54_08710	COG0726	polysaccharide deacetylase
G4P54_08715	COG0612	Peptidase, M16
G4P54_08720	COG1873	PFAM PRC-barrel domain
G4P54_08725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4P54_08730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4P54_08735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4P54_08740	COG0527	aspartate kinase activity
G4P54_08745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4P54_08750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G4P54_08755	COG0740	serine-type endopeptidase activity
G4P54_08765	COG4980	gas vesicle protein
G4P54_08765	COG1674	ftsk spoiiie
G4P54_08770	COG2188	Transcriptional regulator
G4P54_08775	COG2814	Major facilitator Superfamily
G4P54_08780	COG0612	Peptidase, M16
G4P54_08785	COG0612	Peptidase, M16
G4P54_08790	COG0300	oxidoreductase activity
G4P54_08805	COG1426	Protein conserved in bacteria
G4P54_08810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4P54_08815	COG1058	Belongs to the CinA family
G4P54_08815	COG1546	Belongs to the CinA family
G4P54_08820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G4P54_08825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4P54_08830	COG1418	mRNA catabolic process
G4P54_08835	COG1692	metallophosphoesterase
G4P54_08840	COG2359	stage V sporulation protein S
G4P54_08845	COG1063	alcohol dehydrogenase
G4P54_08850	COG0156	8-amino-7-oxononanoate synthase activity
G4P54_08855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4P54_08860	COG4550	Control of competence regulator ComK, YlbF/YmcA
G4P54_08870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G4P54_08875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G4P54_08910	COG3226	Transcriptional regulator
G4P54_08920	COG1404	Belongs to the peptidase S8 family
G4P54_08930	COG4195	phage-related replication protein
G4P54_08935	COG1764	response to oxidative stress
G4P54_08945	COG2076	Multidrug Resistance protein
G4P54_08960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4P54_08965	COG1923	regulation of RNA biosynthetic process
G4P54_08980	COG1780	Probably involved in ribonucleotide reductase function
G4P54_08985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4P54_08990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4P54_08995	COG4112	unkown
G4P54_09000	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4P54_09005	COG0464	growth
G4P54_09030	COG1525	nuclease
G4P54_09040	COG4282	regulation of fungal-type cell wall biogenesis
G4P54_09045	COG5444	nuclease activity
G4P54_09105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4P54_09110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4P54_09120	COG2226	methyltransferase
G4P54_09130	COG2192	nodulation
G4P54_09140	COG0457	Tetratricopeptide repeat
G4P54_09155	COG5632	N-Acetylmuramoyl-L-alanine amidase
G4P54_09155	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_09180	COG2433	Pfam Transposase IS66
G4P54_09190	COG1196	nuclear chromosome segregation
G4P54_09190	COG0739	heme binding
G4P54_09190	COG0741	lytic transglycosylase activity
G4P54_09200	COG0582	viral genome integration into host DNA
G4P54_09285	COG4373	Mu-like prophage FluMu protein gp28
G4P54_09325	COG0776	regulation of translation
G4P54_09405	COG3655	Transcriptional regulator
G4P54_09495	COG0582	viral genome integration into host DNA
G4P54_09510	COG3655	Transcriptional regulator
G4P54_09540	COG3646	Phage regulatory protein
G4P54_09540	COG3645	SOS response
G4P54_09550	COG1388	LysM domain
G4P54_09600	COG1793	dna ligase
G4P54_09605	COG2135	peptidase activity
G4P54_09670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4P54_09680	COG3584	3D domain protein
G4P54_09705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4P54_09820	COG1780	Probably involved in ribonucleotide reductase function
G4P54_09825	COG1372	Participates in initiation and elongation during chromosome replication
G4P54_09825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4P54_09830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4P54_09835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_09845	COG0756	dUTP diphosphatase activity
G4P54_09875	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G4P54_09910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4P54_09965	COG3331	DNA recombination
G4P54_09980	COG0464	growth
G4P54_09985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4P54_09990	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
G4P54_09995	COG0789	Transcriptional regulator
G4P54_10000	COG0174	glutamine synthetase
G4P54_10045	COG2211	Major facilitator Superfamily
G4P54_10050	COG3507	Belongs to the glycosyl hydrolase 43 family
G4P54_10060	COG2115	Belongs to the xylose isomerase family
G4P54_10065	COG1070	Carbohydrate kinase
G4P54_10075	COG1525	nuclease
G4P54_10080	COG2814	Major facilitator Superfamily
G4P54_10095	COG0756	dUTP diphosphatase activity
G4P54_10100	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
G4P54_10115	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G4P54_10140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4P54_10145	COG3832	glyoxalase III activity
G4P54_10165	COG4195	phage-related replication protein
G4P54_10175	COG0346	lactoylglutathione lyase activity
G4P54_10180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4P54_10185	COG1388	LysM domain
G4P54_10190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G4P54_10195	COG4224	UPF0291 protein
G4P54_10200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4P54_10220	COG0785	Cytochrome C biogenesis protein
G4P54_10225	COG2201	protein-glutamate methylesterase activity
G4P54_10230	COG4846	Membrane protein involved in cytochrome C biogenesis
G4P54_10240	COG0071	Belongs to the small heat shock protein (HSP20) family
G4P54_10255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G4P54_10260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_10280	COG0824	Thioesterase
G4P54_10290	COG4841	protein insertion into membrane
G4P54_10295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G4P54_10300	COG1832	CoA-binding protein
G4P54_10305	COG0187	DNA topoisomerase II activity
G4P54_10310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4P54_10320	COG1115	amino acid carrier protein
G4P54_10345	COG0463	Glycosyl transferase, family 2
G4P54_10370	COG3507	Belongs to the glycosyl hydrolase 43 family
G4P54_10405	COG0586	Pfam SNARE associated Golgi protein
G4P54_10410	COG2404	hydrolase activity, acting on ester bonds
G4P54_10415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4P54_10420	COG1024	Enoyl-CoA hydratase
G4P54_10425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4P54_10430	COG0511	ligase activity, forming carbon-carbon bonds
G4P54_10435	COG0439	Biotin carboxylase
G4P54_10440	COG0318	PFAM AMP-dependent synthetase and ligase
G4P54_10445	COG1960	acyl-CoA dehydrogenase activity
G4P54_10450	COG1649	PFAM Uncharacterised BCR, COG1649
G4P54_10460	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G4P54_10460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_10465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_10470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_10475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_10480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_10485	COG2027	D-alanyl-D-alanine carboxypeptidase
G4P54_10490	COG2017	converts alpha-aldose to the beta-anomer
G4P54_10495	COG0534	Mate efflux family protein
G4P54_10505	COG5444	nuclease activity
G4P54_10520	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_10520	COG5632	N-Acetylmuramoyl-L-alanine amidase
G4P54_10545	COG0582	viral genome integration into host DNA
G4P54_10550	COG0166	Belongs to the GPI family
G4P54_10555	COG0405	Gamma-glutamyltransferase
G4P54_10560	COG0583	DNA-binding transcription factor activity
G4P54_10565	COG0604	alcohol dehydrogenase
G4P54_10570	COG0493	'glutamate synthase
G4P54_10575	COG0067	glutamate synthase
G4P54_10575	COG0069	glutamate synthase activity
G4P54_10575	COG0070	glutamate synthase
G4P54_10580	COG0583	DNA-binding transcription factor activity
G4P54_10585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G4P54_10600	COG0300	oxidoreductase activity
G4P54_10605	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
G4P54_10615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4P54_10650	COG1131	(ABC) transporter
G4P54_10660	COG0243	molybdopterin cofactor binding
G4P54_10690	COG2368	4-hydroxyphenylacetate
G4P54_10695	COG4305	rare lipoprotein A
G4P54_10700	COG3619	membrane
G4P54_10710	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_10720	COG2140	Oxalate decarboxylase
G4P54_10730	COG0456	acetyltransferase
G4P54_10745	COG2720	vancomycin resistance protein
G4P54_10755	COG3655	Transcriptional regulator
G4P54_10760	COG3739	integral membrane protein
G4P54_10775	COG0693	protein deglycase activity
G4P54_10780	COG2367	Beta-lactamase
G4P54_10785	COG3848	Pyruvate phosphate dikinase
G4P54_10785	COG0574	Belongs to the PEP-utilizing enzyme family
G4P54_10790	COG1231	oxidoreductase activity
G4P54_10795	COG1064	alcohol dehydrogenase
G4P54_10805	COG0726	polysaccharide deacetylase
G4P54_10815	COG0457	Tetratricopeptide repeat
G4P54_10825	COG3391	amine dehydrogenase activity
G4P54_10835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4P54_10865	COG4282	regulation of fungal-type cell wall biogenesis
G4P54_10875	COG1525	nuclease
G4P54_10885	COG3655	Transcriptional regulator
G4P54_10950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4P54_10955	COG0662	Cupin 2, conserved barrel domain protein
G4P54_10955	COG2207	Transcriptional regulator
G4P54_10960	COG0456	acetyltransferase
G4P54_10965	COG1309	transcriptional regulator
G4P54_10970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4P54_10975	COG3708	Transcriptional regulator
G4P54_10980	COG2378	regulation of single-species biofilm formation
G4P54_10990	COG0640	Transcriptional regulator
G4P54_10995	COG0741	lytic transglycosylase activity
G4P54_11000	COG2322	membrane
G4P54_11015	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4P54_11020	COG3239	Fatty acid desaturase
G4P54_11025	COG4585	Histidine kinase
G4P54_11030	COG2197	response regulator
G4P54_11040	COG3584	3D domain protein
G4P54_11040	COG1388	LysM domain
G4P54_11045	COG0514	ATP-dependent DNA helicase (RecQ)
G4P54_11055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G4P54_11060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4P54_11075	COG0071	Belongs to the small heat shock protein (HSP20) family
G4P54_11100	COG1012	belongs to the aldehyde dehydrogenase family
G4P54_11105	COG1657	PFAM Prenyltransferase squalene oxidase
G4P54_11110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4P54_11115	COG0733	neurotransmitter:sodium symporter activity
G4P54_11120	COG0385	Bile acid
G4P54_11125	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4P54_11130	COG0567	Dehydrogenase, E1 component
G4P54_11135	COG4548	von Willebrand factor, type A
G4P54_11140	COG0714	Associated with various cellular activities
G4P54_11145	COG2032	superoxide dismutase activity
G4P54_11150	COG0791	NLP P60 protein
G4P54_11150	COG1388	LysM domain
G4P54_11155	COG1819	glycosyl
G4P54_11160	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G4P54_11165	COG0534	Mate efflux family protein
G4P54_11170	COG1366	Belongs to the anti-sigma-factor antagonist family
G4P54_11175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4P54_11180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4P54_11190	COG2962	Rard protein
G4P54_11205	COG1733	regulation of RNA biosynthetic process
G4P54_11210	COG0778	Nitroreductase
G4P54_11215	COG0400	carboxylic ester hydrolase activity
G4P54_11220	COG0346	lactoylglutathione lyase activity
G4P54_11230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4P54_11235	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_11235	COG0793	Belongs to the peptidase S41A family
G4P54_11240	COG2226	methyltransferase
G4P54_11250	COG1876	peptidase activity
G4P54_11255	COG0813	purine-nucleoside phosphorylase activity
G4P54_11270	COG0671	phosphoesterase, PA-phosphatase related
G4P54_11290	COG4479	Belongs to the UPF0346 family
G4P54_11300	COG1509	lysine 2,3-aminomutase activity
G4P54_11305	COG0456	acetyltransferase
G4P54_11310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4P54_11315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G4P54_11320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G4P54_11325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4P54_11335	COG0456	acetyltransferase
G4P54_11340	COG0463	Glycosyl transferase, family 2
G4P54_11355	COG4641	Protein conserved in bacteria
G4P54_11380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4P54_11385	COG1846	Transcriptional regulator
G4P54_11390	COG0534	Mate efflux family protein
G4P54_11400	COG4698	Protein conserved in bacteria
G4P54_11405	COG2755	lipolytic protein G-D-S-L family
G4P54_11410	COG1999	signal sequence binding
G4P54_11420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4P54_11425	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
G4P54_11430	COG1272	protein, Hemolysin III
G4P54_11435	COG0204	Acyl-transferase
G4P54_11440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G4P54_11450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4P54_11460	COG2136	Putative SAM-dependent methyltransferase
G4P54_11460	COG2521	methyltransferase
G4P54_11470	COG0129	dihydroxy-acid dehydratase activity
G4P54_11475	COG1413	lyase activity
G4P54_11480	COG1418	mRNA catabolic process
G4P54_11485	COG0386	Belongs to the glutathione peroxidase family
G4P54_11490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
G4P54_11495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4P54_11505	COG1278	Cold shock
G4P54_11525	COG0328	RNA-DNA hybrid ribonuclease activity
G4P54_11530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G4P54_11535	COG0328	RNA-DNA hybrid ribonuclease activity
G4P54_11545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4P54_11560	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G4P54_11570	COG1755	Isoprenylcysteine carboxyl methyltransferase
G4P54_11575	COG3424	synthase
G4P54_11580	COG2233	PERMEase
G4P54_11585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4P54_11590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G4P54_11600	COG1199	ATP-dependent helicase activity
G4P54_11615	COG0116	Belongs to the methyltransferase superfamily
G4P54_11630	COG4474	Belongs to the UPF0398 family
G4P54_11645	COG3359	exonuclease
G4P54_11650	COG1205	dead DEAH box helicase
G4P54_11650	COG1111	helicase
G4P54_11655	COG2190	(PTS) system
G4P54_11660	COG0071	Belongs to the small heat shock protein (HSP20) family
G4P54_11695	COG3331	DNA recombination
G4P54_11700	COG4499	WXG100 protein secretion system (Wss), protein YukC
G4P54_11700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4P54_11710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4P54_11715	COG3935	DnaD domain protein
G4P54_11720	COG0017	Asparaginyl-tRNA synthetase
G4P54_11725	COG0436	Aminotransferase
G4P54_11730	COG5353	protein conserved in bacteria
G4P54_11740	COG1199	ATP-dependent helicase activity
G4P54_11740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4P54_11745	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G4P54_11750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G4P54_11755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G4P54_11760	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G4P54_11760	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G4P54_11765	COG0617	tRNA 3'-terminal CCA addition
G4P54_11770	COG0438	transferase activity, transferring glycosyl groups
G4P54_11775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4P54_11780	COG1803	Methylglyoxal synthase
G4P54_11785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G4P54_11790	COG1694	Mazg nucleotide pyrophosphohydrolase
G4P54_11795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4P54_11805	COG4347	Protein of unknown function (DUF1405)
G4P54_11810	COG2010	Cytochrome c
G4P54_11810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G4P54_11815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G4P54_11820	COG0723	plastoquinol--plastocyanin reductase activity
G4P54_11830	COG5582	Belongs to the UPF0302 family
G4P54_11835	COG0457	Tetratricopeptide repeat
G4P54_11840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G4P54_11845	COG0287	Prephenate dehydrogenase
G4P54_11850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4P54_11855	COG0159	tryptophan synthase activity
G4P54_11860	COG0133	tryptophan synthase activity
G4P54_11865	COG0135	phosphoribosylanthranilate isomerase activity
G4P54_11875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4P54_11880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4P54_11885	COG4401	Chorismate mutase type I
G4P54_11890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G4P54_11895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G4P54_11900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G4P54_11905	COG0105	UTP biosynthetic process
G4P54_11910	COG0142	geranyltranstransferase activity
G4P54_11915	COG2226	methyltransferase
G4P54_11920	COG0142	geranyltranstransferase activity
G4P54_11930	COG0302	gtp cyclohydrolase
G4P54_11935	COG0776	regulation of translation
G4P54_11940	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G4P54_11955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4P54_11960	COG1160	GTP binding
G4P54_11985	COG1304	FMN binding
G4P54_11990	COG0539	negative regulation of cytoplasmic translation
G4P54_11995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4P54_12005	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G4P54_12010	COG2959	enzyme of heme biosynthesis
G4P54_12015	COG3773	Cell wall hydrolase
G4P54_12015	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_12020	COG2339	peptidase activity
G4P54_12025	COG0492	ferredoxin-NADP+ reductase activity
G4P54_12030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4P54_12035	COG4862	establishment of competence for transformation
G4P54_12040	COG1408	metallophosphoesterase
G4P54_12050	COG1388	LysM domain
G4P54_12055	COG1266	CAAX protease self-immunity
G4P54_12060	COG0514	ATP-dependent DNA helicase (RecQ)
G4P54_12065	COG4955	Helix-turn-helix domain
G4P54_12070	COG1141	Ferredoxin
G4P54_12075	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G4P54_12080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4P54_12085	COG0710	3-dehydroquinate dehydratase activity
G4P54_12095	COG1595	DNA-templated transcription, initiation
G4P54_12100	COG5002	protein histidine kinase activity
G4P54_12105	COG0745	RESPONSE REGULATOR receiver
G4P54_12110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4P54_12115	COG1333	cytochrome c biogenesis protein
G4P54_12120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_12125	COG1187	pseudouridine synthase activity
G4P54_12130	COG0700	Nucleoside recognition
G4P54_12135	COG2715	membrane protein required for spore maturation
G4P54_12140	COG1686	Belongs to the peptidase S11 family
G4P54_12150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G4P54_12155	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G4P54_12160	COG1547	Domain of unknown function (DUF309)
G4P54_12165	COG0456	acetyltransferase
G4P54_12170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G4P54_12175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4P54_12175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4P54_12180	COG0307	riboflavin synthase, alpha
G4P54_12185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4P54_12185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4P54_12195	COG0681	Belongs to the peptidase S26 family
G4P54_12210	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
G4P54_12215	COG0586	Pfam SNARE associated Golgi protein
G4P54_12225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4P54_12230	COG4086	secreted protein
G4P54_12235	COG0019	diaminopimelate decarboxylase activity
G4P54_12240	COG0697	spore germination
G4P54_12255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4P54_12275	COG1191	sigma factor activity
G4P54_12280	COG2172	sigma factor antagonist activity
G4P54_12285	COG1366	Belongs to the anti-sigma-factor antagonist family
G4P54_12290	COG1686	Belongs to the peptidase S11 family
G4P54_12295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G4P54_12300	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G4P54_12305	COG4974	Belongs to the 'phage' integrase family
G4P54_12315	COG0735	belongs to the Fur family
G4P54_12320	COG1300	Membrane
G4P54_12330	COG0281	malic enzyme
G4P54_12335	COG1757	Na H antiporter
G4P54_12340	COG1027	Aspartate ammonia-lyase
G4P54_12345	COG0252	asparaginase activity
G4P54_12350	COG1396	sequence-specific DNA binding
G4P54_12355	COG1379	DNA repair
G4P54_12360	COG0494	nUDIX hydrolase
G4P54_12370	COG0667	Aldo Keto reductase
G4P54_12380	COG1073	alpha beta
G4P54_12390	COG4918	Iron-sulphur cluster biosynthesis
G4P54_12395	COG0456	acetyltransferase
G4P54_12395	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G4P54_12400	COG2329	Antibiotic biosynthesis monooxygenase
G4P54_12405	COG0456	acetyltransferase
G4P54_12415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4P54_12425	COG2211	Major facilitator Superfamily
G4P54_12430	COG0346	lactoylglutathione lyase activity
G4P54_12435	COG1072	(Pantothenic acid kinase))
G4P54_12440	COG3048	D-serine ammonia-lyase activity
G4P54_12445	COG0300	oxidoreductase activity
G4P54_12450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4P54_12455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4P54_12460	COG4187	Peptidase family M20/M25/M40
G4P54_12465	COG1902	pentaerythritol trinitrate reductase activity
G4P54_12470	COG0596	Alpha beta hydrolase
G4P54_12480	COG1234	tRNA 3'-trailer cleavage
G4P54_12485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G4P54_12490	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4P54_12495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4P54_12505	COG0706	membrane insertase activity
G4P54_12510	COG3361	conserved protein (COG2071)
G4P54_12515	COG2195	Cleaves the N-terminal amino acid of tripeptides
G4P54_12520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4P54_12525	COG0346	lactoylglutathione lyase activity
G4P54_12535	COG1376	ErfK ybiS ycfS ynhG family protein
G4P54_12540	COG4129	membrane
G4P54_12545	COG1126	abc transporter atp-binding protein
G4P54_12550	COG0765	amino acid transport
G4P54_12555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4P54_12565	COG1597	lipid kinase activity
G4P54_12570	COG2814	Major facilitator Superfamily
G4P54_12575	COG0789	Transcriptional regulator
G4P54_12575	COG4978	Transcriptional regulator
G4P54_12580	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4P54_12585	COG0022	dehydrogenase e1 component
G4P54_12590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4P54_12595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4P54_12600	COG3426	butyrate kinase activity
G4P54_12605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4P54_12610	COG0280	phosphate acetyltransferase
G4P54_12615	COG3290	protein histidine kinase activity
G4P54_12615	COG3829	transcription factor binding
G4P54_12625	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G4P54_12630	COG2079	MmgE PrpD family protein
G4P54_12635	COG0372	Belongs to the citrate synthase family
G4P54_12640	COG1960	acyl-CoA dehydrogenase activity
G4P54_12645	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4P54_12650	COG0183	Belongs to the thiolase family
G4P54_12655	COG0584	glycerophosphoryl diester phosphodiesterase
G4P54_12660	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4P54_12675	COG1902	pentaerythritol trinitrate reductase activity
G4P54_12685	COG0745	RESPONSE REGULATOR receiver
G4P54_12690	COG0750	zinc metalloprotease
G4P54_12695	COG0497	DNA recombination
G4P54_12700	COG1438	arginine binding
G4P54_12705	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G4P54_12710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G4P54_12715	COG0142	geranyltranstransferase activity
G4P54_12720	COG1722	exodeoxyribonuclease VII activity
G4P54_12725	COG1570	exodeoxyribonuclease VII activity
G4P54_12730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4P54_12735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4P54_12740	COG1302	Protein conserved in bacteria
G4P54_12745	COG0439	Biotin carboxylase
G4P54_12750	COG0511	ligase activity, forming carbon-carbon bonds
G4P54_12790	COG3854	ATPases associated with a variety of cellular activities
G4P54_12800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G4P54_12805	COG0006	proline dipeptidase activity
G4P54_12810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G4P54_12820	COG3872	metal-dependent enzyme
G4P54_12830	COG1752	Esterase of the alpha-beta hydrolase superfamily
G4P54_12835	COG1321	iron dependent repressor
G4P54_12840	COG0095	Lipoate-protein ligase
G4P54_12845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4P54_12850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4P54_12855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4P54_12860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G4P54_12865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4P54_12880	COG1396	sequence-specific DNA binding
G4P54_12890	COG0681	Belongs to the peptidase S26 family
G4P54_12915	COG4940	Competence protein ComGF
G4P54_12925	COG4970	Tfp pilus assembly protein FimT
G4P54_12930	COG4537	Required for transformation and DNA binding
G4P54_12935	COG1459	type II secretion system
G4P54_12940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4P54_12950	COG0598	Magnesium transport protein CorA
G4P54_12955	COG1253	flavin adenine dinucleotide binding
G4P54_12960	COG1366	Belongs to the anti-sigma-factor antagonist family
G4P54_12970	COG1393	Belongs to the ArsC family
G4P54_12980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4P54_12990	COG0011	TIGRFAM Protein of
G4P54_13000	COG2866	Carboxypeptidase
G4P54_13005	COG1368	sulfuric ester hydrolase activity
G4P54_13010	COG1940	carbohydrate kinase activity
G4P54_13015	COG4483	Protein conserved in bacteria
G4P54_13020	COG0457	Tetratricopeptide repeat
G4P54_13020	COG0705	Rhomboid family
G4P54_13030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4P54_13040	COG0438	transferase activity, transferring glycosyl groups
G4P54_13055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4P54_13060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4P54_13065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4P54_13070	COG0581	inorganic phosphate transmembrane transporter activity
G4P54_13075	COG0573	inorganic phosphate transmembrane transporter activity
G4P54_13080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4P54_13090	COG0477	Major facilitator Superfamily
G4P54_13095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4P54_13100	COG2839	Protein conserved in bacteria
G4P54_13105	COG5521	maltodextrose utilization protein MalA
G4P54_13110	COG1388	LysM domain
G4P54_13115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G4P54_13120	COG4709	membrane
G4P54_13125	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
G4P54_13130	COG0735	belongs to the Fur family
G4P54_13135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4P54_13145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
G4P54_13150	COG0513	Belongs to the DEAD box helicase family
G4P54_13160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G4P54_13165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G4P54_13170	COG2384	SAM-dependent methyltransferase
G4P54_13175	COG2010	Cytochrome c
G4P54_13180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4P54_13185	COG0358	DNA primase activity
G4P54_13190	COG1671	Belongs to the UPF0178 family
G4P54_13195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G4P54_13200	COG0517	IMP dehydrogenase activity
G4P54_13205	COG0751	glycine-tRNA ligase activity
G4P54_13210	COG0752	glycyl-tRNA synthetase alpha subunit
G4P54_13215	COG1381	Involved in DNA repair and RecF pathway recombination
G4P54_13225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G4P54_13230	COG0295	cytidine deaminase activity
G4P54_13235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G4P54_13240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G4P54_13245	COG1480	7TM receptor with intracellular HD hydrolase
G4P54_13250	COG1702	phosphate starvation-inducible protein PhoH
G4P54_13255	COG0561	phosphatase activity
G4P54_13270	COG4864	UPF0365 protein
G4P54_13275	COG1030	water channel activity
G4P54_13280	COG1610	YqeY-like protein
G4P54_13290	COG1283	sodium-dependent phosphate transmembrane transporter activity
G4P54_13295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4P54_13300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G4P54_13305	COG2264	protein methyltransferase activity
G4P54_13320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4P54_13325	COG1420	regulation of RNA biosynthetic process
G4P54_13330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4P54_13335	COG0481	GTPase activity
G4P54_13345	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4P54_13350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G4P54_13355	COG0268	Binds directly to 16S ribosomal RNA
G4P54_13360	COG1466	dna polymerase III delta subunit
G4P54_13375	COG2333	competence protein COMEC
G4P54_13375	COG0658	competence protein
G4P54_13380	COG2131	deaminase
G4P54_13385	COG1596	polysaccharide export
G4P54_13385	COG1555	photosystem II stabilization
G4P54_13390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4P54_13395	COG2226	methyltransferase
G4P54_13400	COG0799	negative regulation of ribosome biogenesis
G4P54_13405	COG1713	HD superfamily hydrolase involved in NAD metabolism
G4P54_13410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4P54_13415	COG1534	Rna-binding protein
G4P54_13420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4P54_13425	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G4P54_13430	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
G4P54_13440	COG2755	lipolytic protein G-D-S-L family
G4P54_13445	COG5632	N-Acetylmuramoyl-L-alanine amidase
G4P54_13445	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_13450	COG0398	Pfam SNARE associated Golgi protein
G4P54_13465	COG3209	COG3209 Rhs family protein
G4P54_13475	COG1846	Transcriptional regulator
G4P54_13480	COG0477	Major facilitator Superfamily
G4P54_13485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G4P54_13495	COG0604	alcohol dehydrogenase
G4P54_13505	COG3223	Belongs to the PsiE family
G4P54_13510	COG0642	Histidine kinase
G4P54_13510	COG5002	protein histidine kinase activity
G4P54_13515	COG0745	RESPONSE REGULATOR receiver
G4P54_13520	COG2311	Membrane
G4P54_13525	COG0454	-acetyltransferase
G4P54_13535	COG0656	L-ascorbic acid biosynthetic process
G4P54_13555	COG1783	phage Terminase large subunit
G4P54_13640	COG0563	adenylate kinase activity
G4P54_13655	COG0662	Cupin 2, conserved barrel domain protein
G4P54_13665	COG2080	2 iron, 2 sulfur cluster binding
G4P54_13680	COG2068	MobA-Related Protein
G4P54_13685	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G4P54_13700	COG0457	Tetratricopeptide repeat
G4P54_13720	COG2318	DinB family
G4P54_13735	COG2851	Citrate transporter
G4P54_13740	COG0583	DNA-binding transcription factor activity
G4P54_13745	COG2828	Protein conserved in bacteria
G4P54_13750	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_13765	COG0693	protein deglycase activity
G4P54_13770	COG1621	beta-fructofuranosidase activity
G4P54_13775	COG3716	PTS system mannose fructose sorbose family IID component
G4P54_13780	COG3715	PTS system
G4P54_13785	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_13790	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4P54_13795	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
G4P54_13795	COG3933	PFAM sigma-54 factor interaction domain-containing protein
G4P54_13805	COG1113	amino acid transport
G4P54_13815	COG1280	lysine exporter protein (LysE YggA)
G4P54_13820	COG1378	Sugar-specific transcriptional regulator TrmB
G4P54_13825	COG2124	cytochrome p450
G4P54_13825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4P54_13830	COG1309	transcriptional regulator
G4P54_13835	COG2226	methyltransferase
G4P54_13850	COG2116	formate transmembrane transporter activity
G4P54_13855	COG5609	conserved protein (DUF2294)
G4P54_13860	COG3383	formate dehydrogenase (NAD+) activity
G4P54_13865	COG2427	Protein of unknown function (DUF1641)
G4P54_13885	COG0626	cystathionine gamma-synthase activity
G4P54_13890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4P54_13895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4P54_13900	COG2226	methyltransferase
G4P54_13915	COG0768	penicillin binding
G4P54_13920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4P54_13925	COG0572	uridine kinase
G4P54_13940	COG4122	O-methyltransferase activity
G4P54_13945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4P54_13950	COG3906	Belongs to the UPF0473 family
G4P54_13955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G4P54_13960	COG4472	Bacterial protein of unknown function (DUF965)
G4P54_13965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4P54_13970	COG0628	permease
G4P54_13985	COG3881	PFAM PRC-barrel domain
G4P54_13990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4P54_13995	COG0457	Tetratricopeptide repeat
G4P54_14000	COG0482	sulfurtransferase activity
G4P54_14005	COG1104	cysteine desulfurase activity
G4P54_14010	COG1959	2 iron, 2 sulfur cluster binding
G4P54_14015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4P54_14020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4P54_14030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G4P54_14035	COG0124	histidyl-tRNA synthetase
G4P54_14045	COG3103	Sh3 type 3 domain protein
G4P54_14045	COG4991	sh3 domain protein
G4P54_14045	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4P54_14050	COG1490	D-aminoacyl-tRNA deacylase activity
G4P54_14055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4P54_14060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4P54_14065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G4P54_14065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4P54_14070	COG5416	Lipopolysaccharide assembly protein A domain
G4P54_14075	COG0490	domain, Protein
G4P54_14080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4P54_14080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4P54_14090	COG2244	polysaccharide biosynthetic process
G4P54_14095	COG2323	membrane
G4P54_14105	COG1862	Preprotein translocase
G4P54_14110	COG0343	queuine tRNA-ribosyltransferase activity
G4P54_14115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G4P54_14125	COG2255	four-way junction helicase activity
G4P54_14130	COG0632	four-way junction helicase activity
G4P54_14140	COG2814	Major facilitator Superfamily
G4P54_14145	COG0673	inositol 2-dehydrogenase activity
G4P54_14150	COG2112	serine threonine protein kinase
G4P54_14165	COG1115	amino acid carrier protein
G4P54_14170	COG0217	transcriptional regulatory protein
G4P54_14180	COG1388	LysM domain
G4P54_14185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G4P54_14190	COG0157	Belongs to the NadC ModD family
G4P54_14195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G4P54_14200	COG1104	cysteine desulfurase activity
G4P54_14205	COG1827	regulation of RNA biosynthetic process
G4P54_14210	COG0077	Prephenate dehydratase
G4P54_14215	COG4492	Belongs to the UPF0735 family
G4P54_14220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4P54_14225	COG3290	protein histidine kinase activity
G4P54_14235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G4P54_14240	COG2868	ribosomal protein
G4P54_14245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4P54_14250	COG1994	Peptidase M50
G4P54_14255	COG0739	heme binding
G4P54_14260	COG2894	cell division
G4P54_14265	COG0850	regulation of cytokinetic process
G4P54_14270	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G4P54_14280	COG1077	Cell shape determining protein MreB Mrl
G4P54_14285	COG2003	Belongs to the UPF0758 family
G4P54_14290	COG0424	maF-like protein
G4P54_14300	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G4P54_14305	COG0285	dihydrofolate synthase activity
G4P54_14310	COG0525	valine-tRNA ligase activity
G4P54_14320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4P54_14325	COG1388	LysM domain
G4P54_14330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G4P54_14335	COG0113	porphobilinogen synthase activity
G4P54_14340	COG1587	Uroporphyrinogen-III synthase
G4P54_14345	COG0181	hydroxymethylbilane synthase activity
G4P54_14350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4P54_14355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G4P54_14365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G4P54_14370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4P54_14375	COG1067	ATP-dependent peptidase activity
G4P54_14375	COG0470	DNA polymerase III
G4P54_14380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G4P54_14385	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4P54_14390	COG0457	Tetratricopeptide repeat
G4P54_14390	COG1477	protein flavinylation
G4P54_14395	COG0066	3-isopropylmalate dehydratase activity
G4P54_14400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4P54_14405	COG0473	3-isopropylmalate dehydrogenase activity
G4P54_14410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4P54_14415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G4P54_14420	COG0440	acetolactate synthase activity
G4P54_14425	COG0028	Belongs to the TPP enzyme family
G4P54_14435	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
G4P54_14450	COG0622	Phosphoesterase
G4P54_14455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4P54_14460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G4P54_14465	COG5401	PFAM Sporulation and spore germination
G4P54_14470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G4P54_14475	COG1846	Transcriptional regulator
G4P54_14480	COG2197	response regulator
G4P54_14485	COG0824	Thioesterase
G4P54_14490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4P54_14495	COG1053	succinate dehydrogenase
G4P54_14500	COG2009	succinate dehydrogenase
G4P54_14505	COG1719	4-vinyl reductase, 4VR
G4P54_14510	COG0527	aspartate kinase activity
G4P54_14515	COG0322	excinuclease ABC activity
G4P54_14520	COG3118	belongs to the thioredoxin family
G4P54_14525	COG3534	alpha-L-arabinofuranosidase
G4P54_14530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G4P54_14535	COG2086	electron transfer activity
G4P54_14540	COG1024	Enoyl-CoA hydratase
G4P54_14545	COG1309	transcriptional regulator
G4P54_14550	COG0318	PFAM AMP-dependent synthetase and ligase
G4P54_14555	COG3766	membrane
G4P54_14560	COG1193	negative regulation of DNA recombination
G4P54_14565	COG1796	DNA polymerase
G4P54_14565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G4P54_14570	COG1286	toxin biosynthetic process
G4P54_14575	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
G4P54_14580	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4P54_14585	COG0072	phenylalanine-tRNA ligase activity
G4P54_14585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4P54_14590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G4P54_14600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4P54_14610	COG3835	regulator
G4P54_14615	COG0277	FAD linked oxidase domain protein
G4P54_14620	COG0247	lactate metabolic process
G4P54_14625	COG0346	lactoylglutathione lyase activity
G4P54_14635	COG1966	Carbon starvation protein
G4P54_14640	COG3534	alpha-L-arabinofuranosidase
G4P54_14645	COG0395	ABC-type sugar transport system, permease component
G4P54_14650	COG1175	transmembrane transport
G4P54_14655	COG1653	transport
G4P54_14660	COG0371	Dehydrogenase
G4P54_14665	COG0647	UMP catabolic process
G4P54_14670	COG0235	Class ii aldolase
G4P54_14675	COG1069	ribulokinase activity
G4P54_14680	COG2160	L-arabinose isomerase activity
G4P54_14685	COG3507	Belongs to the glycosyl hydrolase 43 family
G4P54_14690	COG1363	Peptidase, m42
G4P54_14700	COG3326	Membrane
G4P54_14710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G4P54_14715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4P54_14725	COG1346	cytolysis
G4P54_14730	COG1380	Effector of murein hydrolase LrgA
G4P54_14735	COG3279	Response regulator of the LytR AlgR family
G4P54_14740	COG3275	phosphorelay sensor kinase activity
G4P54_14745	COG1011	Hydrolase
G4P54_14750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4P54_14760	COG0398	Pfam SNARE associated Golgi protein
G4P54_14765	COG1484	DNA-dependent DNA replication
G4P54_14770	COG3611	Membrane attachment protein
G4P54_14775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G4P54_14780	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G4P54_14785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4P54_14790	COG1733	regulation of RNA biosynthetic process
G4P54_14795	COG2814	Major facilitator Superfamily
G4P54_14800	COG0656	L-ascorbic acid biosynthetic process
G4P54_14805	COG0237	dephospho-CoA kinase activity
G4P54_14810	COG1971	Probably functions as a manganese efflux pump
G4P54_14815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4P54_14820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4P54_14820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4P54_14825	COG5002	protein histidine kinase activity
G4P54_14830	COG0745	RESPONSE REGULATOR receiver
G4P54_14835	COG0039	L-malate dehydrogenase activity
G4P54_14840	COG0538	isocitrate dehydrogenase activity
G4P54_14845	COG0372	Belongs to the citrate synthase family
G4P54_14850	COG2707	UPF0756 membrane protein
G4P54_14855	COG0628	permease
G4P54_14860	COG3030	protein affecting phage T7 exclusion by the F plasmid
G4P54_14865	COG0469	pyruvate kinase activity
G4P54_14870	COG0205	6-phosphofructokinase activity
G4P54_14875	COG0825	malonyl-CoA metabolic process
G4P54_14880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G4P54_14885	COG0281	malic enzyme
G4P54_14890	COG0587	DNA-directed DNA polymerase activity
G4P54_14910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G4P54_14920	COG4109	DRTGG domain
G4P54_14925	COG0730	response to heat
G4P54_14930	COG1473	amidohydrolase
G4P54_14935	COG0196	riboflavin kinase activity
G4P54_14940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4P54_14945	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4P54_14950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4P54_14955	COG1126	abc transporter atp-binding protein
G4P54_14960	COG0765	amino acid transport
G4P54_14965	COG0765	amino acid transport
G4P54_14970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4P54_14975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4P54_14980	COG0454	-acetyltransferase
G4P54_14985	COG0583	DNA-binding transcription factor activity
G4P54_14990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G4P54_14995	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_15000	COG0165	Argininosuccinate lyase
G4P54_15005	COG0137	argininosuccinate synthase activity
G4P54_15010	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4P54_15015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4P54_15020	COG0827	DNA restriction-modification system
G4P54_15025	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G4P54_15030	COG3874	Sporulation protein YtfJ
G4P54_15040	COG1714	RDD family
G4P54_15045	COG0616	signal peptide processing
G4P54_15050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G4P54_15055	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G4P54_15060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4P54_15070	COG0301	tRNA thio-modification
G4P54_15075	COG1104	cysteine desulfurase activity
G4P54_15080	COG1114	Component of the transport system for branched-chain amino acids
G4P54_15085	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
G4P54_15090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G4P54_15095	COG1309	transcriptional regulator
G4P54_15100	COG1956	GAF domain-containing protein
G4P54_15105	COG2199	diguanylate cyclase activity
G4P54_15105	COG2203	Gaf domain
G4P54_15120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G4P54_15125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4P54_15130	COG0454	-acetyltransferase
G4P54_15135	COG0517	IMP dehydrogenase activity
G4P54_15140	COG0123	including yeast histone deacetylase and acetoin utilization protein
G4P54_15145	COG1360	Flagellar Motor Protein
G4P54_15150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4P54_15155	COG1609	Transcriptional regulator
G4P54_15160	COG1605	Chorismate mutase
G4P54_15160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G4P54_15165	COG3118	belongs to the thioredoxin family
G4P54_15170	COG4980	gas vesicle protein
G4P54_15175	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
G4P54_15180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4P54_15185	COG1674	ftsk spoiiie
G4P54_15190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4P54_15195	COG4848	Belongs to the UPF0354 family
G4P54_15200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_15215	COG1363	Peptidase, m42
G4P54_15220	COG5584	Small secreted protein
G4P54_15230	COG0281	malic enzyme
G4P54_15235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4P54_15240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G4P54_15250	COG0510	thiamine kinase activity
G4P54_15255	COG1523	belongs to the glycosyl hydrolase 13 family
G4P54_15260	COG1597	lipid kinase activity
G4P54_15270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G4P54_15275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4P54_15280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4P54_15285	COG2252	PERMEase
G4P54_15290	COG4473	ABC transporter
G4P54_15295	COG1131	(ABC) transporter
G4P54_15300	COG1349	DNA-binding transcription factor activity
G4P54_15305	COG1187	pseudouridine synthase activity
G4P54_15310	COG2244	polysaccharide biosynthetic process
G4P54_15315	COG2081	HI0933 family
G4P54_15320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G4P54_15330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4P54_15335	COG1609	Transcriptional regulator
G4P54_15340	COG1653	transport
G4P54_15345	COG1175	transmembrane transport
G4P54_15350	COG0395	ABC-type sugar transport system, permease component
G4P54_15355	COG1486	melibiose metabolic process
G4P54_15360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4P54_15365	COG0495	leucyl-tRNA aminoacylation
G4P54_15375	COG2202	Pas domain
G4P54_15375	COG1366	Belongs to the anti-sigma-factor antagonist family
G4P54_15380	COG2814	Major facilitator Superfamily
G4P54_15385	COG2433	Pfam Transposase IS66
G4P54_15390	COG0577	efflux transmembrane transporter activity
G4P54_15395	COG1136	(ABC) transporter
G4P54_15400	COG2205	protein histidine kinase activity
G4P54_15405	COG0745	RESPONSE REGULATOR receiver
G4P54_15410	COG0577	efflux transmembrane transporter activity
G4P54_15415	COG1136	(ABC) transporter
G4P54_15430	COG1131	(ABC) transporter
G4P54_15435	COG1725	Transcriptional regulator
G4P54_15445	COG0640	Transcriptional regulator
G4P54_15450	COG0477	Major facilitator Superfamily
G4P54_15455	COG1242	4 iron, 4 sulfur cluster binding
G4P54_15460	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G4P54_15470	COG2267	carboxylic ester hydrolase activity
G4P54_15475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4P54_15480	COG1113	amino acid transport
G4P54_15485	COG0367	asparagine synthase
G4P54_15490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G4P54_15495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G4P54_15505	COG1506	peptidase
G4P54_15510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4P54_15515	COG1116	anion transmembrane transporter activity
G4P54_15520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4P54_15525	COG0494	nUDIX hydrolase
G4P54_15530	COG4824	toxin secretion phage lysis holin
G4P54_15535	COG0783	Belongs to the Dps family
G4P54_15550	COG1854	S-ribosylhomocysteine lyase activity
G4P54_15555	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G4P54_15560	COG0288	reversible hydration of carbon dioxide
G4P54_15565	COG0254	rRNA binding
G4P54_15570	COG1271	oxidase subunit
G4P54_15575	COG1294	oxidase, subunit
G4P54_15585	COG4948	Mandelate Racemase Muconate Lactonizing
G4P54_15590	COG0318	PFAM AMP-dependent synthetase and ligase
G4P54_15595	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G4P54_15600	COG0596	Alpha beta hydrolase
G4P54_15605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
G4P54_15610	COG1169	isochorismate synthase
G4P54_15615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4P54_15620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4P54_15625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4P54_15630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4P54_15635	COG0438	transferase activity, transferring glycosyl groups
G4P54_15645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4P54_15650	COG0438	transferase activity, transferring glycosyl groups
G4P54_15655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4P54_15660	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
G4P54_15665	COG0058	SHG alpha-glucan phosphorylase activity
G4P54_15670	COG0297	glycogen (starch) synthase activity
G4P54_15675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G4P54_15680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G4P54_15685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G4P54_15810	COG3859	Proton-coupled thiamine transporter YuaJ
G4P54_15815	COG1247	-acetyltransferase
G4P54_15820	COG2268	Band 7 protein
G4P54_15825	COG1585	Membrane protein implicated in regulation of membrane protease activity
G4P54_15830	COG2318	DinB family
G4P54_15840	COG1454	alcohol dehydrogenase
G4P54_15845	COG1012	belongs to the aldehyde dehydrogenase family
G4P54_15850	COG1510	regulation of RNA biosynthetic process
G4P54_15860	COG0569	domain protein
G4P54_15865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G4P54_15870	COG4682	membrane
G4P54_15875	COG1705	Flagellar rod assembly protein muramidase FlgJ
G4P54_15880	COG0477	Major facilitator Superfamily
G4P54_15885	COG5553	Cysteine dioxygenase type I
G4P54_15905	COG1968	undecaprenyl-diphosphatase activity
G4P54_15910	COG0628	permease
G4P54_15915	COG0673	inositol 2-dehydrogenase activity
G4P54_15920	COG0840	transmembrane signaling receptor activity
G4P54_15925	COG0840	transmembrane signaling receptor activity
G4P54_15930	COG0840	transmembrane signaling receptor activity
G4P54_15935	COG0840	transmembrane signaling receptor activity
G4P54_15950	COG2070	2-Nitropropane dioxygenase
G4P54_15955	COG0432	Pfam Uncharacterised protein family UPF0047
G4P54_15960	COG0366	Alpha amylase catalytic
G4P54_15965	COG1253	flavin adenine dinucleotide binding
G4P54_15970	COG2738	Putative neutral zinc metallopeptidase
G4P54_15985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4P54_16000	COG0166	Belongs to the GPI family
G4P54_16005	COG1979	alcohol dehydrogenase
G4P54_16010	COG1979	alcohol dehydrogenase
G4P54_16015	COG2155	Conserved Protein
G4P54_16020	COG1098	S1 RNA binding domain
G4P54_16025	COG0436	Aminotransferase
G4P54_16030	COG1522	sequence-specific DNA binding
G4P54_16035	COG2267	carboxylic ester hydrolase activity
G4P54_16045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G4P54_16050	COG2205	protein histidine kinase activity
G4P54_16060	COG5018	Exonuclease
G4P54_16070	COG2814	Major facilitator Superfamily
G4P54_16075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4P54_16080	COG3011	Protein conserved in bacteria
G4P54_16090	COG3290	protein histidine kinase activity
G4P54_16095	COG4565	transcriptional regulatory protein
G4P54_16105	COG3493	citrate carrier protein
G4P54_16115	COG2111	Na H antiporter
G4P54_16115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4P54_16120	COG2111	Na H antiporter
G4P54_16125	COG1006	Multisubunit Na H antiporter MnhC subunit
G4P54_16130	COG0651	ATP synthesis coupled electron transport
G4P54_16135	COG1863	multisubunit Na H antiporter MnhE subunit
G4P54_16140	COG2212	antiporter activity
G4P54_16145	COG1320	monovalent cation:proton antiporter activity
G4P54_16150	COG2050	protein possibly involved in aromatic compounds catabolism
G4P54_16155	COG2197	response regulator
G4P54_16160	COG4585	Histidine kinase
G4P54_16170	COG0142	geranyltranstransferase activity
G4P54_16185	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
G4P54_16190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G4P54_16195	COG1335	isochorismatase
G4P54_16200	COG5506	Protein of unknown function (DUF1694)
G4P54_16215	COG0628	permease
G4P54_16225	COG1418	mRNA catabolic process
G4P54_16230	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G4P54_16240	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_16250	COG1511	domain protein
G4P54_16255	COG1674	ftsk spoiiie
G4P54_16255	COG0433	COG0433 Predicted ATPase
G4P54_16260	COG4499	WXG100 protein secretion system (Wss), protein YukC
G4P54_16265	COG5417	Belongs to the EsaB family
G4P54_16270	COG4842	Belongs to the WXG100 family
G4P54_16275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
G4P54_16275	COG2508	Transcriptional regulator
G4P54_16280	COG0686	Belongs to the AlaDH PNT family
G4P54_16285	COG5634	Uncharacterized conserved protein (DUF2278)
G4P54_16290	COG3251	PFAM MbtH domain protein
G4P54_16295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_16300	COG1535	isochorismatase
G4P54_16300	COG3433	isochorismatase activity
G4P54_16305	COG1021	2,3-dihydroxybenzoate-AMP ligase
G4P54_16310	COG1169	isochorismate synthase
G4P54_16315	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_16320	COG2819	hydrolase of the alpha beta superfamily
G4P54_16325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4P54_16330	COG1268	BioY protein
G4P54_16335	COG2056	Na+-H+ antiporter family
G4P54_16340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G4P54_16345	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
G4P54_16350	COG3584	3D domain protein
G4P54_16365	COG1252	NADH dehydrogenase
G4P54_16370	COG0492	ferredoxin-NADP+ reductase activity
G4P54_16380	COG0516	GMP reductase activity
G4P54_16385	COG0456	acetyltransferase
G4P54_16390	COG0316	Belongs to the HesB IscA family
G4P54_16395	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G4P54_16400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4P54_16405	COG4844	belongs to the
G4P54_16410	COG1252	NADH dehydrogenase
G4P54_16415	COG4837	Protein of unknown function (DUF1462)
G4P54_16420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G4P54_16425	COG4946	Tricorn protease homolog
G4P54_16425	COG1506	peptidase
G4P54_16425	COG0823	Involved in the tonB-independent uptake of proteins
G4P54_16430	COG0083	homoserine kinase activity
G4P54_16435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4P54_16440	COG0460	homoserine dehydrogenase
G4P54_16445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4P54_16450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4P54_16455	COG0647	UMP catabolic process
G4P54_16460	COG2445	Protein of unknown function DUF86
G4P54_16465	COG4470	Protein conserved in bacteria
G4P54_16475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G4P54_16480	COG0739	heme binding
G4P54_16490	COG3377	Domain of unknown function (DUF1805)
G4P54_16495	COG0737	Belongs to the 5'-nucleotidase family
G4P54_16500	COG0730	response to heat
G4P54_16505	COG1801	Protein of unknown function DUF72
G4P54_16515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4P54_16520	COG2508	Transcriptional regulator
G4P54_16525	COG2233	PERMEase
G4P54_16530	COG2233	PERMEase
G4P54_16535	COG3648	Uricase
G4P54_16535	COG3195	allantoin biosynthetic process
G4P54_16540	COG2351	hydroxyisourate hydrolase activity
G4P54_16545	COG1794	racemase activity, acting on amino acids and derivatives
G4P54_16570	COG0457	Tetratricopeptide repeat
G4P54_16580	COG2080	2 iron, 2 sulfur cluster binding
G4P54_16585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4P54_16590	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4P54_16595	COG2068	MobA-Related Protein
G4P54_16600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G4P54_16605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G4P54_16610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4P54_16615	COG2356	endonuclease I
G4P54_16630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4P54_16635	COG3842	ATPase activity
G4P54_16640	COG2188	Transcriptional regulator
G4P54_16645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4P54_16650	COG0395	ABC-type sugar transport system, permease component
G4P54_16655	COG1175	transmembrane transport
G4P54_16660	COG1653	transport
G4P54_16665	COG2222	sugar isomerase
G4P54_16670	COG0789	Transcriptional regulator
G4P54_16685	COG0322	excinuclease ABC activity
G4P54_16690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4P54_16720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G4P54_16735	COG0719	Fe-S assembly protein
G4P54_16740	COG0822	iron-sulfur transferase activity
G4P54_16745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4P54_16750	COG0719	Fe-S assembly protein
G4P54_16755	COG0396	ATPase activity
G4P54_16765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4P54_16770	COG1464	Belongs to the NlpA lipoprotein family
G4P54_16775	COG2011	ABC-type metal ion transport system permease component
G4P54_16780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G4P54_16790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4P54_16795	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
G4P54_16805	COG0509	glycine decarboxylation via glycine cleavage system
G4P54_16810	COG1393	Belongs to the ArsC family
G4P54_16815	COG1960	acyl-CoA dehydrogenase activity
G4P54_16820	COG0183	Belongs to the thiolase family
G4P54_16825	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4P54_16825	COG1024	Enoyl-CoA hydratase
G4P54_16835	COG0506	proline dehydrogenase activity
G4P54_16845	COG5577	PFAM Coat F domain
G4P54_16850	COG1846	Transcriptional regulator
G4P54_16855	COG0477	Major facilitator Superfamily
G4P54_16860	COG1942	4-Oxalocrotonate Tautomerase
G4P54_16865	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_16870	COG0583	DNA-binding transcription factor activity
G4P54_16880	COG1120	ATPase activity
G4P54_16895	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_16900	COG0783	Belongs to the Dps family
G4P54_16910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4P54_16915	COG0745	RESPONSE REGULATOR receiver
G4P54_16920	COG2770	Histidine kinase
G4P54_16920	COG2205	protein histidine kinase activity
G4P54_16930	COG1309	transcriptional regulator
G4P54_16935	COG0114	fumarate hydratase activity
G4P54_16945	COG0697	spore germination
G4P54_16950	COG0814	amino acid
G4P54_16960	COG2197	response regulator
G4P54_16965	COG4585	Histidine kinase
G4P54_16970	COG4758	membrane
G4P54_16975	COG3595	metallopeptidase activity
G4P54_16980	COG1842	Phage shock protein A
G4P54_16985	COG4758	membrane
G4P54_16990	COG2814	Major facilitator Superfamily
G4P54_16995	COG2096	Adenosyltransferase
G4P54_17000	COG1120	ATPase activity
G4P54_17005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_17010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4P54_17015	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_17020	COG3386	PFAM SMP-30 Gluconolaconase
G4P54_17025	COG2205	protein histidine kinase activity
G4P54_17030	COG0745	RESPONSE REGULATOR receiver
G4P54_17040	COG1191	sigma factor activity
G4P54_17050	COG2140	Oxalate decarboxylase
G4P54_17060	COG0577	efflux transmembrane transporter activity
G4P54_17065	COG1136	(ABC) transporter
G4P54_17070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4P54_17075	COG1120	ATPase activity
G4P54_17080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_17085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4P54_17090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4P54_17095	COG0531	amino acid
G4P54_17105	COG1988	membrane-bound metal-dependent
G4P54_17110	COG1368	sulfuric ester hydrolase activity
G4P54_17115	COG1910	domain protein
G4P54_17120	COG0725	ABC transporter, periplasmic molybdate-binding protein
G4P54_17125	COG4149	molybdate abc transporter
G4P54_17130	COG0656	L-ascorbic acid biosynthetic process
G4P54_17140	COG0025	NhaP-type Na H and K H
G4P54_17145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4P54_17150	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4P54_17155	COG3973	AAA domain
G4P54_17160	COG2860	membrane
G4P54_17165	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G4P54_17170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4P54_17175	COG2217	Heavy metal translocating P-type atpase
G4P54_17180	COG2217	Heavy metal translocating P-type atpase
G4P54_17185	COG2608	mercury ion transmembrane transporter activity
G4P54_17190	COG1937	Protein conserved in bacteria
G4P54_17195	COG0673	inositol 2-dehydrogenase activity
G4P54_17200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G4P54_17205	COG1289	transmembrane transporter activity
G4P54_17210	COG1802	Transcriptional regulator
G4P54_17215	COG0697	spore germination
G4P54_17225	COG2076	Multidrug Resistance protein
G4P54_17230	COG1309	transcriptional regulator
G4P54_17235	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_17245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G4P54_17250	COG0557	exoribonuclease II activity
G4P54_17255	COG1647	Serine aminopeptidase, S33
G4P54_17260	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4P54_17265	COG0596	Alpha beta hydrolase
G4P54_17270	COG1476	TRANSCRIPTIONal
G4P54_17275	COG1396	sequence-specific DNA binding
G4P54_17280	COG1396	sequence-specific DNA binding
G4P54_17285	COG1733	regulation of RNA biosynthetic process
G4P54_17290	COG0840	transmembrane signaling receptor activity
G4P54_17300	COG1732	Glycine betaine
G4P54_17305	COG1174	glycine betaine transport
G4P54_17310	COG0517	IMP dehydrogenase activity
G4P54_17310	COG1125	glycine betaine transport
G4P54_17315	COG1510	regulation of RNA biosynthetic process
G4P54_17320	COG1174	glycine betaine transport
G4P54_17325	COG1732	Glycine betaine
G4P54_17330	COG1174	glycine betaine transport
G4P54_17335	COG1125	glycine betaine transport
G4P54_17335	COG0517	IMP dehydrogenase activity
G4P54_17340	COG1510	regulation of RNA biosynthetic process
G4P54_17345	COG2095	MarC family integral membrane protein
G4P54_17350	COG3064	Membrane
G4P54_17355	COG4640	response to antibiotic
G4P54_17360	COG0456	acetyltransferase
G4P54_17375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4P54_17395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4P54_17400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4P54_17410	COG2234	aminopeptidase activity
G4P54_17420	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G4P54_17430	COG0126	phosphoglycerate kinase activity
G4P54_17440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4P54_17445	COG2390	Transcriptional regulator
G4P54_17450	COG2814	Major facilitator Superfamily
G4P54_17455	COG1609	Transcriptional regulator
G4P54_17460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4P54_17465	COG0583	DNA-binding transcription factor activity
G4P54_17470	COG0697	spore germination
G4P54_17475	COG1113	amino acid transport
G4P54_17480	COG3858	chitin binding
G4P54_17485	COG1556	Lactate utilization protein
G4P54_17490	COG1139	Iron-sulfur cluster binding protein
G4P54_17495	COG0247	lactate metabolic process
G4P54_17510	COG2197	response regulator
G4P54_17515	COG4585	Histidine kinase
G4P54_17520	COG0842	Transport permease protein
G4P54_17525	COG1131	(ABC) transporter
G4P54_17530	COG0596	Alpha beta hydrolase
G4P54_17535	COG2208	phosphoserine phosphatase activity
G4P54_17540	COG3867	Arabinogalactan endo-beta-1,4-galactanase
G4P54_17545	COG1874	Beta-galactosidase
G4P54_17550	COG3833	ABC-type maltose transport systems, permease component
G4P54_17555	COG1609	Transcriptional regulator
G4P54_17560	COG2186	Transcriptional regulator
G4P54_17565	COG1620	l-lactate permease
G4P54_17575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G4P54_17585	COG5039	Polysaccharide pyruvyl transferase
G4P54_17590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4P54_17595	COG0110	maltose O-acetyltransferase activity
G4P54_17600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4P54_17605	COG2244	polysaccharide biosynthetic process
G4P54_17610	COG1216	Glycosyl transferase, family 2
G4P54_17615	COG5039	Polysaccharide pyruvyl transferase
G4P54_17620	COG1216	Glycosyl transferase, family 2
G4P54_17630	COG0438	transferase activity, transferring glycosyl groups
G4P54_17635	COG1215	transferase activity, transferring glycosyl groups
G4P54_17640	COG0438	transferase activity, transferring glycosyl groups
G4P54_17645	COG1086	Polysaccharide biosynthesis protein
G4P54_17650	COG0489	protein tyrosine kinase activity
G4P54_17655	COG3944	biosynthesis protein
G4P54_17660	COG1396	sequence-specific DNA binding
G4P54_17665	COG2272	Belongs to the type-B carboxylesterase lipase family
G4P54_17675	COG3479	Phenolic acid decarboxylase
G4P54_17685	COG1794	racemase activity, acting on amino acids and derivatives
G4P54_17695	COG1621	beta-fructofuranosidase activity
G4P54_17700	COG1621	beta-fructofuranosidase activity
G4P54_17705	COG0531	amino acid
G4P54_17710	COG1309	transcriptional regulator
G4P54_17715	COG2076	Multidrug Resistance protein
G4P54_17720	COG2076	Multidrug Resistance protein
G4P54_17730	COG0277	FAD linked oxidase domain protein
G4P54_17735	COG3621	Patatin-like phospholipase
G4P54_17745	COG0740	serine-type endopeptidase activity
G4P54_17750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4P54_17755	COG0366	Alpha amylase catalytic
G4P54_17760	COG1554	hydrolase, family 65, central catalytic
G4P54_17765	COG5521	maltodextrose utilization protein MalA
G4P54_17770	COG3833	ABC-type maltose transport systems, permease component
G4P54_17775	COG1175	transmembrane transport
G4P54_17780	COG2182	Extracellular solute-binding protein
G4P54_17785	COG0366	Alpha amylase catalytic
G4P54_17790	COG1609	Transcriptional regulator
G4P54_17795	COG1611	Belongs to the LOG family
G4P54_17800	COG1694	Mazg nucleotide pyrophosphohydrolase
G4P54_17805	COG0659	secondary active sulfate transmembrane transporter activity
G4P54_17810	COG0288	reversible hydration of carbon dioxide
G4P54_17815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4P54_17820	COG0577	efflux transmembrane transporter activity
G4P54_17825	COG1136	(ABC) transporter
G4P54_17830	COG5002	protein histidine kinase activity
G4P54_17835	COG0745	RESPONSE REGULATOR receiver
G4P54_17845	COG2162	N-hydroxyarylamine O-acetyltransferase activity
G4P54_17850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4P54_17855	COG1481	regulation of sporulation
G4P54_17860	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4P54_17865	COG1660	Displays ATPase and GTPase activities
G4P54_17870	COG1051	belongs to the nudix hydrolase family
G4P54_17875	COG0492	ferredoxin-NADP+ reductase activity
G4P54_17880	COG3883	PFAM NLP P60 protein
G4P54_17880	COG0791	NLP P60 protein
G4P54_17885	COG0457	Tetratricopeptide repeat
G4P54_17890	COG1132	(ABC) transporter
G4P54_17920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G4P54_17920	COG0140	phosphoribosyl-ATP diphosphatase activity
G4P54_17925	COG0107	imidazoleglycerol-phosphate synthase activity
G4P54_17930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G4P54_17935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4P54_17940	COG0131	Imidazoleglycerol-phosphate dehydratase
G4P54_17945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4P54_17950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G4P54_17955	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G4P54_17960	COG4990	cell redox homeostasis
G4P54_17970	COG0110	maltose O-acetyltransferase activity
G4P54_17975	COG0546	phosphoglycolate phosphatase activity
G4P54_17980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G4P54_17985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G4P54_17990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G4P54_17995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4P54_18000	COG0363	glucosamine-6-phosphate deaminase activity
G4P54_18010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4P54_18015	COG1846	Transcriptional regulator
G4P54_18025	COG1950	PFAM Membrane protein of
G4P54_18030	COG1983	PspC domain protein
G4P54_18035	COG3595	metallopeptidase activity
G4P54_18050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4P54_18055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4P54_18060	COG0556	nucleotide-excision repair
G4P54_18065	COG4897	Protein conserved in bacteria
G4P54_18075	COG3848	Pyruvate phosphate dikinase
G4P54_18075	COG0574	Belongs to the PEP-utilizing enzyme family
G4P54_18080	COG1309	transcriptional regulator
G4P54_18085	COG2814	Major facilitator Superfamily
G4P54_18090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4P54_18100	COG3409	Peptidoglycan-binding domain 1 protein
G4P54_18100	COG0793	Belongs to the peptidase S41A family
G4P54_18105	COG2177	Part of the ABC transporter FtsEX involved in
G4P54_18110	COG2884	Cell division ATP-binding protein ftsE
G4P54_18115	COG2010	Cytochrome c
G4P54_18120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4P54_18135	COG0653	protein targeting
G4P54_18140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4P54_18155	COG1516	flagellar protein fliS
G4P54_18160	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G4P54_18165	COG1334	flagellar protein FlaG
G4P54_18170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4P54_18175	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G4P54_18180	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
G4P54_18190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4P54_18195	COG1256	bacterial-type flagellum assembly
G4P54_18195	COG4786	Flagellar basal body rod
G4P54_18200	COG3418	PFAM FlgN family protein
G4P54_18205	COG2747	anti-sigma28 factor FlgM
G4P54_18215	COG1040	competence protein
G4P54_18225	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
G4P54_18230	COG1307	EDD domain protein, DegV family
G4P54_18235	COG2197	response regulator
G4P54_18240	COG4585	Histidine kinase
G4P54_18245	COG1739	Uncharacterized protein family UPF0029
G4P54_18250	COG1316	TRANSCRIPTIONal
G4P54_18255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4P54_18260	COG0438	transferase activity, transferring glycosyl groups
G4P54_18265	COG1215	transferase activity, transferring glycosyl groups
G4P54_18270	COG3206	protein involved in exopolysaccharide biosynthesis
G4P54_18275	COG3307	-O-antigen
G4P54_18280	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4P54_18285	COG0438	transferase activity, transferring glycosyl groups
G4P54_18285	COG0297	glycogen (starch) synthase activity
G4P54_18290	COG2244	polysaccharide biosynthetic process
G4P54_18300	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4P54_18300	COG2247	cell wall binding repeat
G4P54_18305	COG2247	cell wall binding repeat
G4P54_18305	COG2385	sporulation resulting in formation of a cellular spore
G4P54_18315	COG1316	TRANSCRIPTIONal
G4P54_18320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G4P54_18330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4P54_18335	COG1134	teichoic acid transport
G4P54_18340	COG1682	transport, permease protein
G4P54_18345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4P54_18350	COG1442	glycosyl transferase family 8
G4P54_18350	COG1216	Glycosyl transferase, family 2
G4P54_18390	COG4193	domain, Protein
G4P54_18395	COG1482	cell wall glycoprotein biosynthetic process
G4P54_18400	COG0697	spore germination
G4P54_18405	COG0814	amino acid
G4P54_18415	COG2814	Major facilitator Superfamily
G4P54_18420	COG1316	TRANSCRIPTIONal
G4P54_18425	COG0561	phosphatase activity
G4P54_18430	COG0791	NLP P60 protein
G4P54_18440	COG2843	Capsule synthesis protein
G4P54_18450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4P54_18455	COG1609	Transcriptional regulator
G4P54_18460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4P54_18465	COG1869	D-ribose catabolic process
G4P54_18470	COG1129	ABC transporter
G4P54_18475	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4P54_18480	COG1879	ABC-type sugar transport system periplasmic component
G4P54_18485	COG3103	Sh3 type 3 domain protein
G4P54_18495	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4P54_18500	COG3527	Alpha-acetolactate decarboxylase
G4P54_18505	COG0028	Belongs to the TPP enzyme family
G4P54_18510	COG0583	DNA-binding transcription factor activity
G4P54_18515	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G4P54_18530	COG5337	Spore coat protein CotH
G4P54_18540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4P54_18545	COG0405	Gamma-glutamyltransferase
G4P54_18550	COG1522	sequence-specific DNA binding
G4P54_18555	COG2059	Chromate
G4P54_18560	COG2059	Chromate
G4P54_18570	COG0655	NAD(P)H dehydrogenase (quinone) activity
G4P54_18575	COG0583	DNA-binding transcription factor activity
G4P54_18605	COG5444	nuclease activity
G4P54_18630	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4P54_18635	COG4464	protein tyrosine phosphatase activity
G4P54_18640	COG0489	protein tyrosine kinase activity
G4P54_18645	COG3944	biosynthesis protein
G4P54_18655	COG4715	Zinc finger, swim domain protein
G4P54_18660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4P54_18665	COG0561	phosphatase activity
G4P54_18670	COG1349	DNA-binding transcription factor activity
G4P54_18675	COG0629	single-stranded DNA binding
G4P54_18690	COG1970	mechanosensitive ion channel activity
G4P54_18695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4P54_18700	COG0457	Tetratricopeptide repeat
G4P54_18705	COG4786	Flagellar basal body rod
G4P54_18710	COG4786	Flagellar basal body rod
G4P54_18715	COG1077	Cell shape determining protein MreB Mrl
G4P54_18720	COG1609	Transcriptional regulator
G4P54_18730	COG1846	Transcriptional regulator
G4P54_18735	COG2814	Major facilitator Superfamily
G4P54_18745	COG3420	alginic acid biosynthetic process
G4P54_18750	COG1953	Uracil, thiamine, allantoin
G4P54_18755	COG0477	Major facilitator Superfamily
G4P54_18760	COG1335	isochorismatase
G4P54_18770	COG0004	ammonium transporteR
G4P54_18775	COG0347	Belongs to the P(II) protein family
G4P54_18780	COG0671	phosphoesterase, PA-phosphatase related
G4P54_18790	COG0739	heme binding
G4P54_18795	COG1247	-acetyltransferase
G4P54_18805	COG1086	Polysaccharide biosynthesis protein
G4P54_18810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4P54_18815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4P54_18820	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
G4P54_18835	COG2089	acid synthase
G4P54_18845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4P54_18850	COG0789	Transcriptional regulator
G4P54_18860	COG2910	NAD(P)H-binding
G4P54_18865	COG1959	2 iron, 2 sulfur cluster binding
G4P54_18870	COG0804	urea catabolic process
G4P54_18875	COG0832	Belongs to the urease beta subunit family
G4P54_18880	COG0831	urea catabolic process
G4P54_18910	COG3237	CsbD-like
G4P54_18915	COG1994	Peptidase M50
G4P54_18920	COG0457	Tetratricopeptide repeat
G4P54_18925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G4P54_18930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G4P54_18940	COG2304	oxidoreductase activity
G4P54_18945	COG2304	oxidoreductase activity
G4P54_18950	COG2385	sporulation resulting in formation of a cellular spore
G4P54_18955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4P54_18965	COG4836	Membrane
G4P54_18975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G4P54_18980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4P54_18985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G4P54_18990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4P54_18995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4P54_19000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G4P54_19010	COG0356	it plays a direct role in the translocation of protons across the membrane
G4P54_19020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G4P54_19025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G4P54_19030	COG4475	Protein of unknown function (DUF436)
G4P54_19035	COG0698	ribose 5-phosphate isomerase
G4P54_19040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4P54_19045	COG1971	Probably functions as a manganese efflux pump
G4P54_19050	COG0009	L-threonylcarbamoyladenylate synthase
G4P54_19055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G4P54_19075	COG2890	protein-(glutamine-N5) methyltransferase activity
G4P54_19080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G4P54_19085	COG0346	lactoylglutathione lyase activity
G4P54_19090	COG0789	Transcriptional regulator
G4P54_19095	COG0679	Auxin Efflux Carrier
G4P54_19100	COG0281	malic enzyme
G4P54_19105	COG1435	thymidine kinase activity
G4P54_19115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G4P54_19125	COG1494	fructose-1,6-bisphosphatase
G4P54_19130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4P54_19135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4P54_19140	COG0191	fructose-bisphosphate aldolase activity
G4P54_19145	COG2204	response regulator
G4P54_19150	COG4821	SIS domain
G4P54_19155	COG0504	CTP synthase activity
G4P54_19160	COG3343	RNA polymerase activity
G4P54_19165	COG1960	acyl-CoA dehydrogenase activity
G4P54_19170	COG0247	lactate metabolic process
G4P54_19170	COG2181	nitrate reductase activity
G4P54_19175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4P54_19180	COG4294	response to UV
G4P54_19190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4P54_19200	COG2181	nitrate reductase activity
G4P54_19205	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G4P54_19210	COG1140	nitrate reductase beta subunit
G4P54_19215	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G4P54_19220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4P54_19230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4P54_19235	COG2223	nitrite transmembrane transporter activity
G4P54_19240	COG0018	arginyl-trna synthetase
G4P54_19245	COG4506	Protein conserved in bacteria
G4P54_19255	COG0535	radical SAM domain protein
G4P54_19265	COG1131	(ABC) transporter
G4P54_19290	COG3391	amine dehydrogenase activity
G4P54_19295	COG0457	Tetratricopeptide repeat
G4P54_19320	COG1131	(ABC) transporter
G4P54_19330	COG0010	Belongs to the arginase family
G4P54_19335	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G4P54_19340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4P54_19355	COG1994	Peptidase M50
G4P54_19360	COG1942	4-Oxalocrotonate Tautomerase
G4P54_19365	COG1846	Transcriptional regulator
G4P54_19370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4P54_19375	COG0477	Major facilitator Superfamily
G4P54_19380	COG1959	2 iron, 2 sulfur cluster binding
G4P54_19385	COG3465	dGTPase activity
G4P54_19390	COG1078	dGTPase activity
G4P54_19395	COG4844	belongs to the
G4P54_19405	COG0697	spore germination
G4P54_19410	COG0095	Lipoate-protein ligase
G4P54_19415	COG0583	DNA-binding transcription factor activity
G4P54_19420	COG0280	phosphate acetyltransferase
G4P54_19430	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_19435	COG0436	Aminotransferase
G4P54_19440	COG2814	Major facilitator Superfamily
G4P54_19445	COG0151	Belongs to the GarS family
G4P54_19450	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_19455	COG1917	Cupin 2, conserved barrel domain protein
G4P54_19460	COG0077	Prephenate dehydratase
G4P54_19465	COG2814	Major facilitator Superfamily
G4P54_19475	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
G4P54_19480	COG1091	dTDP-4-dehydrorhamnose reductase activity
G4P54_19485	COG1088	dTDP-glucose 4,6-dehydratase activity
G4P54_19490	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G4P54_19500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G4P54_19505	COG0463	Glycosyl transferase, family 2
G4P54_19515	COG2363	Small membrane protein
G4P54_19530	COG1012	belongs to the aldehyde dehydrogenase family
G4P54_19535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G4P54_19540	COG1216	Glycosyl transferase, family 2
G4P54_19555	COG1695	Transcriptional regulator
G4P54_19560	COG0351	phosphomethylpyrimidine kinase
G4P54_19570	COG1621	beta-fructofuranosidase activity
G4P54_19575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_19575	COG1263	PTS System
G4P54_19585	COG3711	transcriptional antiterminator
G4P54_19595	COG1404	Belongs to the peptidase S8 family
G4P54_19600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4P54_19605	COG0778	Nitroreductase
G4P54_19610	COG0772	Belongs to the SEDS family
G4P54_19620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G4P54_19625	COG1845	cytochrome c oxidase, subunit III
G4P54_19630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4P54_19635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4P54_19640	COG2261	transglycosylase associated protein
G4P54_19645	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
G4P54_19650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G4P54_19655	COG2246	polysaccharide biosynthetic process
G4P54_19660	COG1309	transcriptional regulator
G4P54_19670	COG3162	membrane
G4P54_19675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4P54_19680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G4P54_19685	COG2837	iron assimilation
G4P54_19690	COG2822	iron ion transport
G4P54_19695	COG0672	)-iron permease
G4P54_19700	COG0352	thiamine-phosphate diphosphorylase activity
G4P54_19705	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
G4P54_19710	COG0583	DNA-binding transcription factor activity
G4P54_19715	COG1380	Effector of murein hydrolase LrgA
G4P54_19720	COG1346	cytolysis
G4P54_19725	COG2814	Major facilitator Superfamily
G4P54_19730	COG4895	conserved protein (DUF2196)
G4P54_19735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G4P54_19740	COG0346	lactoylglutathione lyase activity
G4P54_19750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4P54_19755	COG1404	Belongs to the peptidase S8 family
G4P54_19760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_19760	COG1263	PTS System
G4P54_19765	COG3711	transcriptional antiterminator
G4P54_19770	COG1442	glycosyl transferase family 8
G4P54_19775	COG5522	Integral membrane protein (intg_mem_TP0381)
G4P54_19780	COG2234	aminopeptidase activity
G4P54_19795	COG2814	Major facilitator Superfamily
G4P54_19800	COG2357	RelA SpoT domain protein
G4P54_19805	COG1575	Belongs to the MenA family. Type 1 subfamily
G4P54_19815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4P54_19820	COG1696	Membrane protein involved in D-alanine export
G4P54_19825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4P54_19830	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
G4P54_19835	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
G4P54_19840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4P54_19845	COG1486	melibiose metabolic process
G4P54_19850	COG1447	Phosphotransferase system cellobiose-specific component IIA
G4P54_19855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4P54_19860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4P54_19865	COG3711	transcriptional antiterminator
G4P54_19865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4P54_19875	COG2094	Belongs to the DNA glycosylase MPG family
G4P54_19880	COG0753	catalase activity
G4P54_19885	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G4P54_19890	COG1131	(ABC) transporter
G4P54_19910	COG1595	DNA-templated transcription, initiation
G4P54_19915	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G4P54_19920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G4P54_19925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4P54_19930	COG4988	ABC transporter
G4P54_19935	COG1294	oxidase, subunit
G4P54_19940	COG1271	oxidase subunit
G4P54_19945	COG3493	citrate carrier protein
G4P54_19950	COG0501	Belongs to the peptidase M48B family
G4P54_19960	COG0726	polysaccharide deacetylase
G4P54_19965	COG3842	ATPase activity
G4P54_19970	COG2508	Transcriptional regulator
G4P54_19975	COG1012	belongs to the aldehyde dehydrogenase family
G4P54_19980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4P54_19990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4P54_20000	COG4585	Histidine kinase
G4P54_20005	COG2197	response regulator
G4P54_20010	COG2195	Cleaves the N-terminal amino acid of tripeptides
G4P54_20015	COG4894	glucomannan catabolic process
G4P54_20020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4P54_20025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4P54_20030	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_20035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G4P54_20040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G4P54_20045	COG2610	gluconate transmembrane transporter activity
G4P54_20050	COG0500	methyltransferase
G4P54_20055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4P54_20070	COG0753	catalase activity
G4P54_20070	COG0693	protein deglycase activity
G4P54_20075	COG2851	Citrate transporter
G4P54_20090	COG3711	transcriptional antiterminator
G4P54_20100	COG2270	Major facilitator Superfamily
G4P54_20105	COG0513	Belongs to the DEAD box helicase family
G4P54_20170	COG0589	response to stress
G4P54_20175	COG2723	6-phospho-beta-galactosidase activity
G4P54_20180	COG1263	PTS System
G4P54_20180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4P54_20180	COG2190	(PTS) system
G4P54_20190	COG5444	nuclease activity
G4P54_20210	COG0494	nUDIX hydrolase
G4P54_20275	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G4P54_20280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4P54_20285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G4P54_20290	COG2390	Transcriptional regulator
G4P54_20300	COG2079	MmgE PrpD family protein
G4P54_20305	COG1473	amidohydrolase
G4P54_20310	COG1126	abc transporter atp-binding protein
G4P54_20315	COG0765	amino acid transport
G4P54_20320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4P54_20325	COG0456	acetyltransferase
G4P54_20330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4P54_20335	COG0561	phosphatase activity
G4P54_20365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4P54_20375	COG1012	belongs to the aldehyde dehydrogenase family
G4P54_20380	COG1349	DNA-binding transcription factor activity
G4P54_20385	COG0667	Aldo Keto reductase
G4P54_20410	COG2814	Major facilitator Superfamily
G4P54_20415	COG0326	Molecular chaperone. Has ATPase activity
G4P54_20425	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_20430	COG1309	transcriptional regulator
G4P54_20435	COG1012	belongs to the aldehyde dehydrogenase family
G4P54_20440	COG1714	RDD family
G4P54_20445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4P54_20455	COG1714	RDD family
G4P54_20460	COG2311	Membrane
G4P54_20465	COG1028	Short-chain dehydrogenase reductase Sdr
G4P54_20470	COG1846	Transcriptional regulator
G4P54_20475	COG1380	Effector of murein hydrolase LrgA
G4P54_20480	COG1346	cytolysis
G4P54_20505	COG5039	Polysaccharide pyruvyl transferase
G4P54_20510	COG1929	Belongs to the glycerate kinase type-1 family
G4P54_20515	COG1802	Transcriptional regulator
G4P54_20520	COG1070	Carbohydrate kinase
G4P54_20525	COG2610	gluconate transmembrane transporter activity
G4P54_20530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4P54_20535	COG0450	alkyl hydroperoxide reductase
G4P54_20540	COG3634	alkyl hydroperoxide reductase activity
G4P54_20550	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
G4P54_20560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G4P54_20575	COG1063	alcohol dehydrogenase
G4P54_20595	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
G4P54_20600	COG0456	acetyltransferase
G4P54_20605	COG0457	Tetratricopeptide repeat
G4P54_20615	COG0010	Belongs to the arginase family
G4P54_20620	COG0833	amino acid
G4P54_20625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4P54_20630	COG3829	transcription factor binding
G4P54_20635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4P54_20640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G4P54_20645	COG4853	Protein conserved in bacteria
G4P54_20650	COG4863	YycH protein
G4P54_20655	COG5002	protein histidine kinase activity
G4P54_20660	COG0745	RESPONSE REGULATOR receiver
G4P54_20690	COG0346	lactoylglutathione lyase activity
G4P54_20695	COG0305	Participates in initiation and elongation during chromosome replication
G4P54_20710	COG3093	addiction module antidote protein HigA
G4P54_20715	COG2807	transmembrane transport
G4P54_20720	COG0359	binds to the 23S rRNA
G4P54_20725	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
G4P54_20730	COG4241	membrane
G4P54_20740	COG5577	PFAM Coat F domain
G4P54_20745	COG1733	regulation of RNA biosynthetic process
G4P54_20750	COG1227	inorganic diphosphatase activity
G4P54_20755	COG2271	Major facilitator Superfamily
G4P54_20775	COG0071	Belongs to the small heat shock protein (HSP20) family
G4P54_20790	COG4319	ketosteroid isomerase
G4P54_20795	COG1357	PFAM Pentapeptide repeats (8 copies)
G4P54_20800	COG2814	Major facilitator Superfamily
G4P54_20805	COG0583	DNA-binding transcription factor activity
G4P54_20810	COG2153	protein acetylation
G4P54_20815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4P54_20820	COG1846	Transcriptional regulator
G4P54_20825	COG2153	protein acetylation
G4P54_20830	COG2364	Membrane
G4P54_20835	COG2814	Major facilitator Superfamily
G4P54_20855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4P54_20890	COG1331	Highly conserved protein containing a thioredoxin domain
G4P54_20915	COG1331	Highly conserved protein containing a thioredoxin domain
G4P54_20920	COG1331	Highly conserved protein containing a thioredoxin domain
G4P54_20925	COG1266	CAAX protease self-immunity
G4P54_20930	COG2814	Major facilitator Superfamily
G4P54_20930	COG0477	Major facilitator Superfamily
G4P54_20935	COG0110	maltose O-acetyltransferase activity
G4P54_20940	COG0346	lactoylglutathione lyase activity
G4P54_20945	COG1609	Transcriptional regulator
G4P54_20950	COG0708	Exodeoxyribonuclease III
G4P54_20955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4P54_20960	COG0629	single-stranded DNA binding
G4P54_20965	COG0360	Binds together with S18 to 16S ribosomal RNA
G4P54_20970	COG0012	GTP binding
G4P54_20975	COG0243	molybdopterin cofactor binding
G4P54_20980	COG4481	Protein conserved in bacteria
G4P54_20985	COG3949	Membrane
G4P54_20995	COG1475	DNA binding
G4P54_21000	COG1192	Involved in chromosome partitioning
G4P54_21010	COG1475	DNA binding
G4P54_21015	COG0357	Ribosomal RNA small subunit methyltransferase G
G4P54_21020	COG0445	tRNA wobble uridine modification
G4P54_21025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G4P54_21030	COG1847	R3H domain protein
G4P54_21035	COG0706	membrane insertase activity
G4P54_21040	COG0594	ribonuclease P activity