locus-tag class description BG06_1 ENOG4105T9C HD domain BG06_10 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BG06_1000 ENOG4105CRE cytochrome C BG06_1001 ENOG4107TWT Cytochrome c biogenesis protein BG06_1003 ENOG4105FE9 pseudouridine synthase BG06_1005 ENOG4108JIC nucleoside recognition domain protein BG06_1006 ENOG4105DZ1 carboxypeptidase BG06_1007 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG06_1014 ENOG4105BZU Histidine kinase BG06_1017 ENOG4105I3N Conserved Protein BG06_1018 ENOG4105BZU Histidine kinase BG06_102 ENOG4108JCI Transcriptional regulator BG06_1021 ENOG4105BZ4 penicillin-binding protein BG06_1022 ENOG4107GRR phosphate transport regulator BG06_1023 ENOG4105CJ3 phosphate transporter BG06_1032 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BG06_1036 ENOG4105WH1 Two component transcriptional regulator luxr family BG06_1037 ENOG4105ENE Histidine kinase BG06_1041 ENOG4105DFD Na H antiporter BG06_1047 ENOG4105C8J )-transporter BG06_1048 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BG06_1049 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BG06_1050 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BG06_1052 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BG06_1053 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BG06_1057 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BG06_1059 ENOG4105E0M Sulfatase BG06_106 ENOG4105BZ1 (ABC) transporter BG06_1060 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BG06_1063 ENOG4107RVV histidinol phosphate phosphatase, hisj family BG06_107 ENOG4105BZ1 (ABC) transporter BG06_1078 ENOG4108ZP8 Acetolactate synthase small subunit BG06_1079 ENOG4105C7K acetolactate synthase BG06_1080 ENOG4105CM2 brancheD-chain amino acid aminotransferase BG06_1085 ENOG4105KBJ sporulation protein ytfj BG06_1086 ENOG41063Y9 BG06_1087 ENOG4105CZN Potassium uptake protein BG06_11 ENOG4107QX3 carboxylase BG06_110 ENOG4108RPX mosc domain containing protein BG06_1101 ENOG4105NQC Flavodoxin BG06_1106 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BG06_1108 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BG06_1109 ENOG4105EA8 2-Nitropropane dioxygenase BG06_111 ENOG4105DND Transcriptional regulator BG06_1110 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BG06_1118 ENOG4105CJ1 ABC, transporter BG06_1120 ENOG4105CZV ABC transporter BG06_1121 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BG06_1122 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG06_1123 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG06_1124 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG06_1125 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BG06_1133 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BG06_1134 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BG06_1136 ENOG4105BZU Histidine kinase BG06_1138 ENOG4106DF1 BG06_114 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BG06_1140 ENOG41090MY MarR family Transcriptional regulator BG06_1141 ENOG4105BZU Histidine kinase BG06_1143 ENOG4105PXI polysaccharide deacetylase BG06_1145 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BG06_1148 ENOG4105E98 transcriptional regulator DeoR family BG06_115 ENOG4107V2S Transcriptional regulator BG06_1151 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BG06_1152 ENOG4107RCV ABC transporter, permease BG06_1153 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BG06_1154 ENOG4105C4Y ABC transporter BG06_1158 ENOG4105MWK D-amino acid dehydrogenase, small subunit BG06_1160 ENOG4105CHR reductase BG06_1164 ENOG4108Z7G MaoC domain protein dehydratase BG06_1165 ENOG410681C small acid-soluble spore protein BG06_1166 ENOG4105CZN Potassium uptake protein BG06_1167 ENOG4107TS3 membrane protein, TerC BG06_1168 ENOG4108QTI )-transporter BG06_1170 ENOG4106A3R peptidase BG06_1174 ENOG4105JXH GntR family transcriptional regulator BG06_1175 ENOG4105BZU Histidine kinase BG06_1176 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG06_1179 ENOG4105CQB FAD linked oxidase domain protein BG06_1180 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BG06_1181 ENOG4105K4I Scp-like extracellular BG06_1183 ENOG4108YBP pseudouridine synthase BG06_1185 ENOG4105EYF MMPL domain protein BG06_1187 ENOG4107RUE extracellular solute-binding protein family 1 BG06_1188 ENOG4105D38 putrescine abc transporter BG06_1189 ENOG4105F38 ABC transporter, permease BG06_1191 ENOG4105C26 Dehydrogenase BG06_1197 ENOG4105VFR signal peptidase BG06_1198 ENOG4105DZ1 carboxypeptidase BG06_12 ENOG4105E39 Enoyl-CoA hydratase BG06_1200 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BG06_1209 ENOG4105VZ8 Transcriptional regulator BG06_1211 ENOG4105C7S Dehydrogenase BG06_1215 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BG06_1230 ENOG4105DDQ anthranilate synthase BG06_1231 ENOG4105CRQ synthase (Component I) BG06_1232 ENOG4105CK7 Sodium proline symporter BG06_1246 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BG06_1248 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BG06_1249 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BG06_1253 ENOG4107TVC Glycosyl transferase, family 2 BG06_1257 ENOG4105K64 Glycosyl transferase, family 2 BG06_1261 ENOG4105EMS pseudouridine synthase BG06_1262 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BG06_1265 ENOG4105MIX Adenylate cyclase BG06_1266 ENOG4108Z18 K06886 hemoglobin BG06_1269 ENOG4105DPN Oligoendopeptidase f BG06_1271 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG06_1273 ENOG4108ZCF integral membrane protein BG06_1277 ENOG4105UQX Mate efflux family protein BG06_1278 ENOG4108JQ7 (ABC) transporter BG06_128 ENOG4105VEQ Cold shock protein BG06_1280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG06_1281 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG06_1284 ENOG4105C31 Tryptophanyl-tRNA synthetase BG06_1287 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BG06_1288 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BG06_1293 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BG06_1295 ENOG4108KP7 hydrolase BG06_1297 ENOG41073B9 BG06_1298 ENOG4107AYK membrAne BG06_13 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BG06_130 ENOG41068WN BG06_1300 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG06_1301 ENOG4105QNR S1 RNA binding domain protein BG06_1307 ENOG4105BZU Histidine kinase BG06_1308 ENOG4105CH6 catalase BG06_1310 ENOG4105CAQ asparagine synthetase BG06_1315 ENOG4105ERH Fumarylacetoacetate hydrolase BG06_132 ENOG4105C1Q protoporphyrinogen oxidase BG06_1331 ENOG4105BZU Histidine kinase BG06_1332 ENOG4105XVF Competence transcription factor BG06_1335 ENOG4105VEQ Cold shock protein BG06_1338 ENOG4107QP3 malate synthase g BG06_1343 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BG06_1348 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG06_1352 ENOG41086D8 Transcriptional regulator BG06_1353 ENOG4108AEY RNA polymerase sigma factor BG06_1355 ENOG4107TVP HD domain protein BG06_1356 ENOG4107RN3 metallophosphoesterase BG06_1357 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BG06_1361 ENOG4105CEY Amp-dependent synthetase and ligase BG06_1363 ENOG4105DF9 Lipoate-protein, ligase BG06_1364 ENOG4108RQ5 Beta-lactamase domain-containing protein BG06_1365 ENOG4106AXD BG06_1367 ENOG4105D29 Helix-turn-helix type 11 domain protein BG06_1369 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BG06_1373 ENOG4105ECB domain protein BG06_1379 ENOG4105C1Q protoporphyrinogen oxidase BG06_1382 ENOG4105BZ4 penicillin-binding protein BG06_1383 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BG06_1384 ENOG4105CKV Membrane BG06_1385 ENOG410905X membrane-flanked domain protein BG06_1392 ENOG4105CKV Membrane BG06_1393 ENOG410905X membrane-flanked domain protein BG06_14 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BG06_1400 ENOG4105K59 histidine triad (HIT) protein BG06_1405 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG06_1406 ENOG4105EEM helicase BG06_1408 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG06_1409 ENOG4105C57 major facilitator superfamily BG06_1412 ENOG4105CNI cell division protein FtsW BG06_1414 ENOG4105EMN RNA polymerase sigma factor BG06_1420 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BG06_1423 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BG06_1430 ENOG4108MUZ hydrolase BG06_1437 ENOG4106D4I domain protein BG06_1438 ENOG4107VRP DNA repair exonuclease BG06_1447 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG06_1449 ENOG4105K8R UPF0145 protein BG06_145 ENOG4105VUN Transcriptional regulator BG06_1454 ENOG4105BZU Histidine kinase BG06_1455 ENOG4105BZU Histidine kinase BG06_1456 ENOG4108MJI response regulator BG06_1458 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG06_1460 ENOG4105WN5 stage II sporulation protein BG06_147 ENOG4105CHH sulfate transporter BG06_1474 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BG06_148 ENOG4107YZX Universal stress protein BG06_1481 ENOG4105CMT Dihydroxyacetone kinase BG06_1483 ENOG4105CMT Dihydroxyacetone kinase BG06_1488 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BG06_149 ENOG4105CN5 Metallo-Beta-Lactamase BG06_1490 ENOG4105CS2 ec 3.2.1.21 BG06_1491 ENOG4105C5Y PTS System BG06_1492 ENOG4105CID antiterminator BG06_15 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BG06_150 ENOG4108MEK Metal-binding protein YodA BG06_152 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BG06_1520 ENOG4105CDU Replicative dna helicase BG06_1530 ENOG4108MRH transcriptional regulatory protein BG06_1532 ENOG4105CSH Transporter BG06_1537 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BG06_1541 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BG06_1543 ENOG4108JQ7 (ABC) transporter BG06_1545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG06_155 ENOG4107UGY Proline imino-peptidase BG06_1551 ENOG4105F32 YngK protein BG06_1557 ENOG4108IBT Inherit from COG: transposase BG06_1564 ENOG4108IBT Inherit from COG: transposase BG06_157 ENOG4108QY0 Membrane BG06_1573 ENOG4105DER m42 family BG06_1577 ENOG4105CGU Enoyl-CoA hydratase BG06_158 ENOG410900G Protein of unknown function (DUF421) BG06_1580 ENOG4105IEH endo-beta-N-acetylglucosaminidase BG06_1588 ENOG4105CHH sulfate transporter BG06_159 ENOG4108QY0 Membrane BG06_1591 ENOG4105D4P Coproporphyrinogen iii oxidase BG06_1596 ENOG4107FQX Alpha-acetolactate decarboxylase BG06_16 ENOG4105C1G acyl-Coa dehydrogenase BG06_1603 ENOG410839P BG06_1606 ENOG4105CDA abc transporter atp-binding protein BG06_1607 ENOG4105DRP amino acid AbC transporter BG06_1609 ENOG4105BZ1 (ABC) transporter BG06_161 ENOG4107TSN permease BG06_1610 ENOG4105BZ1 (ABC) transporter BG06_1611 ENOG4105C26 Dehydrogenase BG06_1613 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BG06_1614 ENOG4105D5Q Arginine ornithine antiporter BG06_1616 ENOG4105CH6 catalase BG06_1617 ENOG4107RKG DJ-1/PfpI family BG06_1619 ENOG4105E5W Transporter BG06_1620 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BG06_1621 ENOG4105NF4 modulator of drug activity BG06_1626 ENOG4105KPY Small multidrug resistance protein BG06_1627 ENOG4105KPY Small multidrug resistance protein BG06_1629 ENOG4108YXU transcriptional regulator AsnC family BG06_1637 ENOG4106KNT transcriptional regulator BG06_1639 ENOG4107RWR Sodium hydrogen exchanger BG06_1640 ENOG4105CUB amino acid BG06_1647 ENOG4107T5V SNARE associated Golgi BG06_165 ENOG4105WCN acetyltransferase BG06_1654 ENOG4105WEF catalase BG06_1660 ENOG4105C19 ABC transporter BG06_1661 ENOG4107RBB ABC transporter, permease BG06_1662 ENOG41069ER domain protein BG06_1666 ENOG4105VZJ PTS System BG06_1667 ENOG4105VCP PTS System BG06_1668 ENOG4105EMD TRANSCRIPTIONal BG06_1672 ENOG4105CZN Potassium uptake protein BG06_1673 ENOG4108KGH TRANSCRIPTIONal BG06_1675 ENOG41087NI Sulfite exporter TauE/SafE BG06_1676 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BG06_1678 ENOG41085GJ domain protein BG06_1679 ENOG4105VFE sira family BG06_1680 ENOG4107TPS domain protein BG06_1681 ENOG4105VFE sira family BG06_1682 ENOG4105XTG Pfam:DUF156 BG06_1683 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BG06_1687 ENOG4105ED1 spovr family BG06_1688 ENOG4107Y03 Nitroreductase BG06_169 ENOG4105EYF MMPL domain protein BG06_1692 ENOG4108B31 Spore germination protein BG06_1699 ENOG4105C5Y PTS System BG06_1703 ENOG4108PXI ErfK YbiS YcfS YnhG BG06_1705 ENOG4105C7N Xanthine uracil vitamin C permease BG06_1706 ENOG4108QGH periplasmic BG06_1707 ENOG4105C2J ABC transporter BG06_1708 ENOG4105CNN ABC, transporter BG06_171 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BG06_1710 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BG06_1715 ENOG4108INS Transcriptional regulator BG06_1724 ENOG4105DWF phosphomethylpyrimidine kinase BG06_1725 ENOG4105D06 uba thif-type nad fad binding protein BG06_1728 ENOG41080HI glycine oxidase BG06_1729 ENOG4108VEU Thiamine monophosphate synthase BG06_1731 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BG06_1733 ENOG4105ETU transcriptional activator (TenA BG06_1737 ENOG41080XQ Signal transduction protein with cbs domains BG06_174 ENOG41081I9 integral membrane protein BG06_1764 ENOG4105E2Z phosphate ABC transporter (Permease BG06_1765 ENOG4105C8U phosphate abc transporter BG06_1766 ENOG4105CVA phosphate BG06_1767 ENOG4105CE1 Ferrous iron transport protein b BG06_1768 ENOG4105CE1 Ferrous iron transport protein b BG06_1769 ENOG4105CE1 Ferrous iron transport protein b BG06_1770 ENOG4108NHD germination protein BG06_1773 ENOG4105E1V na solute symporter BG06_1774 ENOG4106CAD Protein of unknown function (DUF3311) BG06_1777 ENOG4105E2S oxidase) subunit II BG06_1778 ENOG4105BZ9 Cytochrome C oxidase, subunit I BG06_178 ENOG4108D32 Methyltransferase BG06_1783 ENOG4105MA6 gCN5-related N-acetyltransferase BG06_1786 ENOG4105C7N Xanthine uracil vitamin C permease BG06_1787 ENOG4105C85 amino acid BG06_1791 ENOG4105DUX Transporter BG06_1794 ENOG4105VZ8 Transcriptional regulator BG06_1795 ENOG41069ER domain protein BG06_1796 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BG06_1809 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BG06_1810 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BG06_1811 ENOG4105CNN ABC, transporter BG06_1812 ENOG4105C2J ABC transporter BG06_1814 ENOG4108RVA ribokinase BG06_1815 ENOG4105ETE Transcriptional regulator (LacI family BG06_1816 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG06_1817 ENOG41067TZ transcriptional regulator, MarR family BG06_1818 ENOG4105CXY transporter BG06_182 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BG06_1820 ENOG4108JQ7 (ABC) transporter BG06_1821 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG06_1823 ENOG4108J59 Extracellular solute-binding protein, family 5 BG06_1825 ENOG41068KF Universal stress protein BG06_1826 ENOG4105CHH sulfate transporter BG06_1829 ENOG4105BZU Histidine kinase BG06_1830 ENOG4105NAE bifunctional deaminase-reductase domain protein BG06_1831 ENOG4105D29 Helix-turn-helix type 11 domain protein BG06_1836 ENOG4108IQI permease BG06_1837 ENOG4105DRP amino acid AbC transporter BG06_1838 ENOG4105EAD ABC transporter BG06_1839 ENOG4105CT1 (ABC) transporter BG06_184 ENOG4105C19 ABC transporter BG06_1840 ENOG4105CDA abc transporter atp-binding protein BG06_1841 ENOG4105BZG amino acid carrier protein BG06_1842 ENOG4105CRN Aminoglycoside phosphotransferase BG06_1844 ENOG4105E1K spore germination protein BG06_1847 ENOG4105CG3 alpha amylase, catalytic region BG06_1848 ENOG4105C5Y PTS System BG06_1849 ENOG4107414 GntR family transcriptional regulator BG06_185 ENOG4105C22 threonyL-tRNA synthetase BG06_1850 ENOG4105D5Q Arginine ornithine antiporter BG06_1851 ENOG4105BZU Histidine kinase BG06_1854 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG06_1855 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BG06_1856 ENOG4107T89 von Willebrand factor, type A BG06_1858 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BG06_1859 ENOG4105EXW epimerase dehydratase BG06_186 ENOG4105FE9 pseudouridine synthase BG06_1861 ENOG4105DMQ Methyltransferase BG06_1862 ENOG4105E0A ABC, transporter BG06_1863 ENOG4108IHU transport system permease protein BG06_1864 ENOG4105DQ5 transport system permease protein BG06_1865 ENOG4108MES Periplasmic binding protein BG06_1866 ENOG4105DUX Transporter BG06_1869 ENOG4105DAA L-lactate BG06_1870 ENOG4108IJ0 Aspartate ammonia-lyase BG06_1871 ENOG4105C37 (CBS) domain BG06_1872 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BG06_1873 ENOG4105D9N nucleoside BG06_1874 ENOG4108KGH TRANSCRIPTIONal BG06_1877 ENOG41073R8 VanW family BG06_1884 ENOG4105DAP Nicotinate phosphoribosyltransferase BG06_1885 ENOG4105C59 p-type ATPase BG06_1887 ENOG4105CUB amino acid BG06_1891 ENOG4108JB9 formate dehydrogenase BG06_1892 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BG06_1893 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BG06_1895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG06_1896 ENOG4105BZU Histidine kinase BG06_1898 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG06_1899 ENOG4108UZ3 Transporter BG06_19 ENOG4107Z3H Transcriptional regulator, TetR family BG06_190 ENOG4105BZG amino acid carrier protein BG06_1901 ENOG4105C6K Malic enzyme BG06_1903 ENOG4108MRH transcriptional regulatory protein BG06_1908 ENOG4105US7 Histidine kinase BG06_1909 ENOG4108STX response regulator BG06_1910 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BG06_1911 ENOG4105BZ7 extracellular solute-binding protein family 1 BG06_1912 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BG06_1913 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BG06_1914 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BG06_1915 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BG06_1919 ENOG4105D4T Citrate transporter BG06_1920 ENOG4108V9W transcriptional regulatory protein BG06_1921 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BG06_1923 ENOG4105DZ6 Band 7 protein BG06_1926 ENOG4105C94 Transporter BG06_1930 ENOG4105CYN Serine protein kinase BG06_1932 ENOG4105BZU Histidine kinase BG06_1933 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BG06_1935 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BG06_1937 ENOG4107ZQN disulfide bond BG06_1938 ENOG4108JQC penicillin-binding protein 1A BG06_194 ENOG4105K70 DNA-binding protein BG06_1962 ENOG4105G5W regulator Fur family BG06_1963 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG06_1967 ENOG4108IUW ABC transporter BG06_1969 ENOG4105CBC glutamate synthase BG06_197 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG06_1970 ENOG4107NBY Membrane BG06_1971 ENOG4105BZ1 (ABC) transporter BG06_1975 ENOG4106BXE BG06_1976 ENOG4105CEN a g-specific adenine glycosylase BG06_1977 ENOG41067AE Membrane-bound metal-dependent hydrolase BG06_198 ENOG4105WQT MbtH domain protein BG06_1983 ENOG4105ECP epimerase BG06_1984 ENOG4105CI2 imidazolone-5-propionate hydrolase BG06_1988 ENOG4105F1A Pyruvate formate-lyase BG06_199 ENOG4105CEY Amp-dependent synthetase and ligase BG06_1991 ENOG4105C3I Nad-dependent epimerase dehydratase BG06_1992 ENOG4107QQG Dehydrogenase BG06_1993 ENOG4105CKK Glycosyl transferase, family 2 BG06_1997 ENOG4108A04 Beta-lactamase BG06_1999 ENOG4105CSV Glutaminase BG06_200 ENOG4105WQI isochorismatase BG06_2005 ENOG4108IQI permease BG06_2007 ENOG4108JUB Transcriptional regulator BG06_201 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BG06_2010 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BG06_2017 ENOG4105UPD Calcium Proton BG06_2018 ENOG410606W general stress protein BG06_202 ENOG4105E4F Isochorismate synthase BG06_2021 ENOG4107ZTW SNARE associated Golgi BG06_2026 ENOG4108IPJ Membrane BG06_2027 ENOG4105C59 p-type ATPase BG06_2028 ENOG4107U9T Pfam:Ribonuclease_BN BG06_203 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BG06_2030 ENOG4105KJF protein tyrosine phosphatase BG06_2034 ENOG4108TTB tellurium resistance protein BG06_2035 ENOG4107TS3 membrane protein, TerC BG06_2036 ENOG4106FN3 tellurium resistance protein BG06_2037 ENOG4106FN3 tellurium resistance protein BG06_2038 ENOG4108N0M stress protein BG06_204 ENOG4105FCD Major Facilitator BG06_2044 ENOG4105DEU major facilitator superfamily BG06_2048 ENOG41062JF Transcriptional regulator BG06_2054 ENOG4105C5H ABC transporter BG06_2058 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BG06_2061 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BG06_2067 ENOG4105CI1 PTS System BG06_2071 ENOG4105C5B carbamate kinase BG06_2076 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BG06_2077 ENOG4105C8Q Methyl-accepting chemotaxis BG06_2079 ENOG4105EAB amino acid AbC transporter BG06_2080 ENOG4105E5Q amino acid AbC transporter BG06_2083 ENOG4105D2S major facilitator superfamily BG06_2084 ENOG410756H nucleotidyltransferase BG06_2088 ENOG4105BZU Histidine kinase BG06_2091 ENOG4106UIA BG06_2092 ENOG4106UIA BG06_2096 ENOG4108V5C ABC transporter BG06_2097 ENOG4105DQ5 transport system permease protein BG06_2098 ENOG4105EHG Permease protein BG06_2099 ENOG4107W7X Aldolase BG06_21 ENOG4105CJ1 ABC, transporter BG06_210 ENOG4105EYH Exonuclease BG06_2101 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BG06_2102 ENOG4105D3R alkyl hydroperoxide reductase BG06_2107 ENOG4105DFD Na H antiporter BG06_2108 ENOG4105DTQ mandelate racemase muconate lactonizing BG06_211 ENOG4107RFY SbcCD D subunit BG06_2112 ENOG4108W15 Protein of unknown function (DUF1456) BG06_2113 ENOG4105BZU Histidine kinase BG06_2115 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BG06_2116 ENOG4105D9N nucleoside BG06_2121 ENOG4105KPY Small multidrug resistance protein BG06_2122 ENOG4105C26 Dehydrogenase BG06_2124 ENOG4108JPW Aminotransferase BG06_2125 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BG06_2126 ENOG4105CBD Diacylglycerol kinase BG06_2130 ENOG4107I77 yiaA/B two helix domain BG06_2131 ENOG410834F Transcriptional regulator BG06_2135 ENOG4105D01 (LipO)protein BG06_2136 ENOG4108UMI ABC transporter, permease BG06_2138 ENOG4108W2Y isochorismatase BG06_214 ENOG4105E39 Enoyl-CoA hydratase BG06_2144 ENOG4105C4R Atp-dependent dna helicase BG06_2149 ENOG4105C12 Phosphoribosylglycinamide synthetase BG06_215 ENOG4105N14 lysine exporter protein LysE YggA BG06_2151 ENOG4108V3E phosphoribosylglycinamide formyltransferase BG06_2156 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BG06_2158 ENOG4105C83 adenylosuccinate lyase BG06_2159 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BG06_2160 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BG06_2166 ENOG4105SX7 Transporter BG06_217 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BG06_2171 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG06_218 ENOG4105C1G acyl-Coa dehydrogenase BG06_2185 ENOG4107ZXU DSBA oxidoreductase BG06_219 ENOG4105CR4 methylisocitrate lyase BG06_2190 ENOG4105BZU Histidine kinase BG06_2192 ENOG4105C7N Xanthine uracil vitamin C permease BG06_2196 ENOG4108TYN CAAX amino terminal protease family protein BG06_2199 ENOG4105C5H ABC transporter BG06_220 ENOG4105DXD 2-methylcitrate dehydratase BG06_2201 ENOG410801F ribosomal-protein-alanine acetyltransferase BG06_2202 ENOG41072GX Peptidase M22 Glycoprotease BG06_2203 ENOG4105K8N protein family UPF0079, ATPase BG06_222 ENOG4105W8X HesB YadR YfhF-family protein BG06_2223 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BG06_2225 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BG06_2226 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BG06_2229 ENOG4107ZXI Rhomboid family BG06_223 ENOG4105CZM Major Facilitator BG06_2231 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BG06_2232 ENOG4105CPF Cell wall formation (By similarity) BG06_2233 ENOG4108SC4 )-transporter BG06_2235 ENOG4105ERH Fumarylacetoacetate hydrolase BG06_2236 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BG06_224 ENOG4105BZ4 penicillin-binding protein BG06_2241 ENOG410667J hydrolase BG06_2242 ENOG4108JQ7 (ABC) transporter BG06_2243 ENOG4105C3U ABC transporter BG06_2244 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG06_2246 ENOG4105DEF Extracellular solute-binding protein, family 5 BG06_2249 ENOG4105C5H ABC transporter BG06_2252 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BG06_2254 ENOG4108RE7 deoxyribonuclease BG06_2257 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BG06_2261 ENOG4105F6E Acyl-transferase BG06_2268 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BG06_2269 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BG06_2270 ENOG4105E0C molybdate abc transporter BG06_2272 ENOG4107XDY Nicotinamide Mononucleotide Transporter BG06_2273 ENOG4105II7 pyrroline-5-carboxylate reductase BG06_2275 ENOG4108J59 Extracellular solute-binding protein, family 5 BG06_2276 ENOG4108J59 Extracellular solute-binding protein, family 5 BG06_2278 ENOG4105U5Y Transcriptional regulator BG06_2283 ENOG4108JQ7 (ABC) transporter BG06_2284 ENOG4105C3U ABC transporter BG06_2285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG06_2286 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG06_2289 ENOG4105C2C drug resistance transporter, Bcr CflA BG06_2292 ENOG4105IQ5 FAD linked oxidase domain protein BG06_2294 ENOG4105EE1 crotonyl-CoA reductase BG06_2295 ENOG4108PSK reductase BG06_2299 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BG06_2300 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BG06_2302 ENOG4105CMG Carbohydrate kinase BG06_2304 ENOG4108VQT Alpha beta hydrolase fold protein BG06_2308 ENOG4107U5W ybbr family BG06_2309 ENOG4105C8B TIGR00159 family BG06_232 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG06_2326 ENOG4108NMV polysaccharide deacetylase BG06_2329 ENOG4105D1F ATP-binding protein BG06_2334 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BG06_2335 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BG06_2336 ENOG4108JJB ABC transporter BG06_2342 ENOG41067V7 50S ribosomal protein L36 BG06_2344 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BG06_2346 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BG06_2351 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BG06_2372 ENOG4105XPM ribosomal protein BG06_2375 ENOG4107Y49 methyltransferase BG06_2380 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BG06_2382 ENOG4105QIV RNA polymerase BG06_2383 ENOG4105M0M Tetracycline resistance protein BG06_2384 ENOG4105C2N RNA methyltransferase TrmH family group 3 BG06_2387 ENOG4105D7W serine acetyltransferase BG06_2391 ENOG4105CTP PilT protein domain protein BG06_2393 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BG06_2396 ENOG4108Z0C Uvrb UvrC protein BG06_24 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BG06_2416 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BG06_2418 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BG06_2419 ENOG4105KRF dihydroneopterin aldolase BG06_2420 ENOG4105EEI dihydropteroate synthase BG06_2421 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BG06_2422 ENOG4105DDQ anthranilate synthase BG06_2423 ENOG4105CRQ synthase (Component I) BG06_2424 ENOG4105C6T cysteine synthase BG06_2427 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BG06_2428 ENOG4108UGV hypoxanthine phosphoribosyltransferase BG06_2433 ENOG41060GV RNA binding s1 domain protein BG06_2436 ENOG4105VYY sporulation protein yabp BG06_2437 ENOG41082I2 s4 domain protein BG06_2438 ENOG4108IY2 MazG family BG06_2440 ENOG4108M14 stage v sporulation protein t BG06_2441 ENOG4108JA2 transcriptioN-repair coupling factor BG06_2443 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BG06_2444 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BG06_2447 ENOG4105KME endoribonuclease L-psp BG06_2448 ENOG4105DFT pur operon repressor BG06_2451 ENOG4105W42 Veg protein BG06_2452 ENOG4105XFA sporulation peptidase YabG BG06_2454 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BG06_2455 ENOG4105F8V Hydrolase, tatD family BG06_2457 ENOG4105KRN Transcriptional regulator, abrb family BG06_2458 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BG06_2460 ENOG41060K3 Methyltransferase BG06_2462 ENOG4105MA4 psp1 domain protein BG06_2463 ENOG4105FA2 dna polymerase iii BG06_2465 ENOG4105CXN decarboxylase BG06_2473 ENOG41067KS pro-sigma K processing BG06_2477 ENOG4105C6E dna polymerase iii BG06_2478 ENOG4108Z6B deaminase BG06_2479 ENOG4105GTG Isochorismatase BG06_2481 ENOG4105ZMH deoxynucleoside kinase BG06_2488 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BG06_2496 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG06_2499 ENOG410848D S4 domain protein YaaA BG06_2500 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BG06_2504 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BG06_2506 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BG06_2510 ENOG4107QJE Chromosome Partitioning Protein BG06_2511 ENOG4105FA0 parb-like partition protein BG06_2512 ENOG4108ZDA Sporulation protein YyaC BG06_2513 ENOG4105D8X mechanosensitive ion channel BG06_2514 ENOG4105VDK protein, conserved in bacteria BG06_2515 ENOG4105C3G gtp-binding protein BG06_2517 ENOG4108UUM single-stranded DNA-binding protein BG06_2519 ENOG4108XMW Membrane BG06_2520 ENOG4105BZR domain protein BG06_2522 ENOG4105CDU Replicative dna helicase BG06_2528 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG06_2529 ENOG4105BZU Histidine kinase BG06_253 ENOG4108IBT Inherit from COG: transposase BG06_2532 ENOG4105Q2H domain protein BG06_2533 ENOG4105C0H protease BG06_2537 ENOG4105DPN Oligoendopeptidase f BG06_2540 ENOG4105C1J atp-dependent rna helicase BG06_2543 ENOG4108UT2 hemolysin iii BG06_2544 ENOG4105CMR udp-glucose 4-epimerase BG06_2546 ENOG4105IW1 AmiS UreI transporter BG06_2548 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG06_255 ENOG4105SZ6 Thioredoxin BG06_2551 ENOG4107RGD Major Facilitator superfamily BG06_2552 ENOG4108HRK Histidine kinase BG06_2553 ENOG4105DY9 regulatoR BG06_2556 ENOG4106F5Q Membrane BG06_2559 ENOG4105E0X reductase BG06_256 ENOG410841Q phosphoesterase PA-phosphatase related protein BG06_2561 ENOG41067SE Tetr family transcriptional regulator BG06_2562 ENOG4105CKK Glycosyl transferase, family 2 BG06_2566 ENOG4105C5H ABC transporter BG06_2568 ENOG4105K64 Glycosyl transferase, family 2 BG06_2569 ENOG4108S4H thioesterase Superfamily protein BG06_2571 ENOG4106YBV Methyl-accepting chemotaxis BG06_2572 ENOG4105EN6 Membrane BG06_2576 ENOG41079KZ Major Facilitator Superfamily BG06_2577 ENOG4105DY9 regulatoR BG06_2578 ENOG4105D22 carbon starvation protein BG06_2579 ENOG4105VCD cytoplasmic protein BG06_258 ENOG4108N23 SpoOM-related protein BG06_2580 ENOG4105BZU Histidine kinase BG06_2581 ENOG4105DWF phosphomethylpyrimidine kinase BG06_2582 ENOG4105BZU Histidine kinase BG06_2583 ENOG4105WH1 Two component transcriptional regulator luxr family BG06_2585 ENOG4108Y4K DNA-binding transcriptional activator BG06_2589 ENOG4105D6E homoserine dehydrogenase BG06_2592 ENOG41090WU lipolytic protein G-D-S-L family BG06_2593 ENOG4105CJ1 ABC, transporter BG06_2594 ENOG4108TU7 Inherit from COG: (ABC) transporter BG06_2596 ENOG4105VCH membrane BG06_2597 ENOG410667J hydrolase BG06_2599 ENOG4107SVH Potassium channel protein BG06_2603 ENOG4108VKI Cell wall hydrolase BG06_2606 ENOG4108IJ2 phosphate acetyltransferase BG06_2609 ENOG4108VCI transcription factor, rsfa family BG06_2611 ENOG4105DQ5 transport system permease protein BG06_2612 ENOG4105EHG Permease protein BG06_2613 ENOG4105E0A ABC, transporter BG06_2614 ENOG4108MES Periplasmic binding protein BG06_2615 ENOG4105DCI Phosphohydrolase BG06_2616 ENOG41069HH 4-oxalocrotonate tautomerase BG06_2617 ENOG4108Z4T Peptidase M50 BG06_2618 ENOG4108XFG YwhD family BG06_2619 ENOG4105BZ4 penicillin-binding protein BG06_2620 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BG06_2621 ENOG4107SWG transcriptional regulator MERR family BG06_2622 ENOG4105DXB Major Facilitator superfamily BG06_2624 ENOG4105CYW agmatinase BG06_2628 ENOG410684U Domain of unknown function (DUF1934) BG06_2630 ENOG4105DU6 RNA polymerase BG06_2634 ENOG4105IIU Aminopeptidase BG06_2636 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BG06_2637 ENOG4108M15 ABC transporter BG06_2638 ENOG4105KCT ABC transporter BG06_2639 ENOG4105BZU Histidine kinase BG06_2643 ENOG4105BZU Histidine kinase BG06_2646 ENOG4105DF6 Fe-S oxidoreductase BG06_2648 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BG06_2649 ENOG4105C1G acyl-Coa dehydrogenase BG06_2650 ENOG4105C1G acyl-Coa dehydrogenase BG06_2657 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BG06_2658 ENOG4105CBT Fructose-1,6-bisphosphatase BG06_2659 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BG06_266 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BG06_2662 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BG06_2663 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BG06_2664 ENOG4108ZXQ stage ii sporulation protein r BG06_2666 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BG06_267 ENOG4108JUB Transcriptional regulator BG06_2671 ENOG4107XC4 flavin reductase domain protein, FMN-binding BG06_2672 ENOG4108VGI doxx family BG06_2675 ENOG4108YZG isomerase BG06_268 ENOG4108TSC N-acetyltransferase BG06_2680 ENOG41062M3 atp synthase BG06_2681 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BG06_269 ENOG4107S4Y M20 DapE family protein YgeY BG06_2691 ENOG4105BZU Histidine kinase BG06_2694 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BG06_2700 ENOG4105D65 subunit l BG06_2701 ENOG4105C8S subunit m BG06_2702 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BG06_2703 ENOG4106778 Protein of unknown function (DUF1146) BG06_2707 ENOG4105DY9 regulatoR BG06_2710 ENOG4105FRN stage II sporulation protein BG06_2711 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BG06_2714 ENOG4107YJ4 chain length determinant protein BG06_2715 ENOG4105HTX biosynthesis protein BG06_2716 ENOG4107YJ4 chain length determinant protein BG06_2717 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BG06_2718 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BG06_2719 ENOG4105D3Q Sugar transferase BG06_272 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG06_2723 ENOG4105CJR Integral membrane protein (MviN BG06_2725 ENOG4108IJ1 Dehydrogenase BG06_2726 ENOG4105D7W serine acetyltransferase BG06_2727 ENOG4108KGH TRANSCRIPTIONal BG06_2729 ENOG4105CMR udp-glucose 4-epimerase BG06_2730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG06_2731 ENOG4105BZU Histidine kinase BG06_2734 ENOG4105CXY transporter BG06_2738 ENOG4105C19 ABC transporter BG06_2739 ENOG4107RBB ABC transporter, permease BG06_2742 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG06_2748 ENOG4105C0D helicase BG06_2749 ENOG4105KBK Zinc finger, swim domain protein BG06_2754 ENOG41069ER domain protein BG06_2755 ENOG4105C94 Transporter BG06_2757 ENOG4107R8N Glycosyl transferase, family 2 BG06_2762 ENOG4105E0M Sulfatase BG06_2764 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BG06_2766 ENOG4105DAA L-lactate BG06_277 ENOG4105C37 (CBS) domain BG06_2775 ENOG4107RSM transcriptional regulator BG06_2776 ENOG4105ECB domain protein BG06_2777 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BG06_2780 ENOG4105VZJ PTS System BG06_2782 ENOG4105VCP PTS System BG06_2786 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BG06_2788 ENOG4105CK1 PTS System BG06_2789 ENOG4105VCP PTS System BG06_2790 ENOG4105F8D glycoside hydrolase family 4 BG06_2794 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BG06_2796 ENOG4105ESV Glycosyl transferase, family 4 BG06_2797 ENOG4105C6Y Udp-glucose 6-dehydrogenase BG06_2798 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BG06_2799 ENOG4108KGH TRANSCRIPTIONal BG06_28 ENOG4105BZU Histidine kinase BG06_2800 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BG06_2802 ENOG4105KVH Transcriptional regulator BG06_2803 ENOG4105K4H Nlp p60 protein BG06_2805 ENOG41081UC Inherit from COG: Competence protein BG06_2806 ENOG4105VEQ Cold shock protein BG06_2807 ENOG4105MS2 ribosomal subunit Interface protein BG06_2809 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BG06_2812 ENOG4105CAK Cell division ATP-binding protein ftsE BG06_2813 ENOG4105CRP Part of the ABC transporter FtsEX involved in BG06_2814 ENOG4105CN1 protease BG06_2816 ENOG4105BZ1 (ABC) transporter BG06_2819 ENOG4108WS4 fmn reductase BG06_2821 ENOG4105DUM transcriptional regulator, lysR family BG06_2822 ENOG4105HMI Membrane BG06_2828 ENOG4107TXC Transcriptional regulator BG06_2832 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BG06_2834 ENOG41086DT Membrane protein of unknown function BG06_2838 ENOG4108S4C acetyltransferase BG06_284 ENOG4105E90 ABC transporter BG06_2840 ENOG4105C3M thioredoxin reductase BG06_2842 ENOG4108Z4K mutator MutT protein BG06_2844 ENOG4105CHW UPF0052 protein BG06_2846 ENOG4105KRI phosphocarrier protein (HPr BG06_2847 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BG06_2848 ENOG4105H67 Protein of unknown function (DUF421) BG06_285 ENOG4108IJ8 ABC transporter BG06_2851 ENOG4105CZ3 stage V sporulation protein ad BG06_2852 ENOG41090VF Stage v sporulation protein ac BG06_2856 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG06_2862 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BG06_2866 ENOG41067MG lrgb family BG06_2867 ENOG4105XZU Preprotein translocase, subunit SecG BG06_2869 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BG06_2872 ENOG4105DHF Membrane BG06_2874 ENOG4107ZTW SNARE associated Golgi BG06_2878 ENOG4105C19 ABC transporter BG06_2883 ENOG4105CM4 permease protein BG06_2884 ENOG4108IPW abc transporter atp-binding protein BG06_2887 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BG06_2888 ENOG4108MK9 spermidine N(1)-acetyltransferase BG06_2894 ENOG4105C8Q Methyl-accepting chemotaxis BG06_29 ENOG4105C5H ABC transporter BG06_2902 ENOG4105KVH Transcriptional regulator BG06_2903 ENOG4105F27 Major Facilitator BG06_2904 ENOG4105CV8 reductase BG06_2907 ENOG4108RYK Nad-dependent epimerase dehydratase BG06_2909 ENOG4105D9N nucleoside BG06_291 ENOG4105CMG Carbohydrate kinase BG06_2910 ENOG4105D9N nucleoside BG06_2914 ENOG4108URH decarboxylase BG06_2917 ENOG4108RMU ferritin dps family protein BG06_2919 ENOG4105NCW Trka-c domain protein BG06_292 ENOG4105CMG Carbohydrate kinase BG06_2920 ENOG4107S91 Sodium hydrogen exchanger BG06_2924 ENOG4105D4Y metalloprotease BG06_2925 ENOG4105VG1 fes assembly suf system protein BG06_2926 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BG06_2927 ENOG4105C8Q Methyl-accepting chemotaxis BG06_2931 ENOG4105BZU Histidine kinase BG06_2932 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG06_2933 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BG06_2935 ENOG4107ZTW SNARE associated Golgi BG06_2943 ENOG4107AYK membrAne BG06_2945 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BG06_2947 ENOG4107R7I amino acid BG06_2948 ENOG4108SUT Major Facilitator Superfamily BG06_2952 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BG06_2956 ENOG4105DZ1 carboxypeptidase BG06_2959 ENOG4105CHU acetyl-coa acetyltransferase BG06_2960 ENOG4105C1G acyl-Coa dehydrogenase BG06_2961 ENOG4108W8B Beta-lactamase domain protein BG06_2977 ENOG41080E8 Transcriptional regulator, Spx MgsR family BG06_298 ENOG4106KNT transcriptional regulator BG06_2983 ENOG4108UMI ABC transporter, permease BG06_2984 ENOG4105D01 (LipO)protein BG06_2985 ENOG4105D01 (LipO)protein BG06_2986 ENOG4105C3K feS assembly ATPase SufC BG06_2987 ENOG4105JRK feS assembly protein SufD BG06_2988 ENOG4105C9B Cysteine desulfurase BG06_2989 ENOG4108UNV SUF system FeS assembly protein, NifU family BG06_2990 ENOG4105DIW FeS assembly protein SUFB BG06_2991 ENOG4107R8B 5'-nucleotidase BG06_2992 ENOG4105KZD Domain of unknown function (DUF1805) BG06_2994 ENOG4105FAA peptidase M23 BG06_2999 ENOG41090T1 Membrane BG06_30 ENOG41067SE Tetr family transcriptional regulator BG06_300 ENOG4105WH1 Two component transcriptional regulator luxr family BG06_3000 ENOG4107TXC Transcriptional regulator BG06_3001 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BG06_3002 ENOG4105MMD transcriptional regulator BG06_3006 ENOG4105CBT Fructose-1,6-bisphosphatase BG06_3009 ENOG4105D4U had-superfamily hydrolase, subfamily iia BG06_301 ENOG4105BZU Histidine kinase BG06_3011 ENOG4105DYS nad(p)h dehydrogenase (quinone) BG06_3012 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BG06_3015 ENOG4108W5N phosphatidylglycerophosphatase a BG06_3018 ENOG41083MR nifu domain-containing protein BG06_302 ENOG4105D8X mechanosensitive ion channel BG06_3023 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BG06_3024 ENOG4105C4B ABC transporter, permease BG06_3025 ENOG4108JJA ABC, transporter BG06_3029 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BG06_303 ENOG4107Y70 Heat shock protein BG06_3031 ENOG4105EWC Purine nucleoside phosphorylase BG06_3037 ENOG4105CEP NADH dehydrogenase BG06_3040 ENOG41069ER domain protein BG06_3044 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BG06_3049 ENOG4105KA0 thioesterase Superfamily protein BG06_3053 ENOG4107R3E Citrate transporter BG06_3055 ENOG4105Y38 Kinase-associated protein B BG06_3058 ENOG4105C87 Aminotransferase class I and II BG06_3060 ENOG4108MUZ hydrolase BG06_3061 ENOG4105C5I Dehydrogenase BG06_3062 ENOG4108ZB6 transcriptional regulator AsnC family BG06_3063 ENOG4105CHM Aminotransferase BG06_3065 ENOG4105WG9 Conserved Protein BG06_3067 ENOG4107PBV potassium channel BG06_3069 ENOG4105KT7 mgtC SapB transporter BG06_3077 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BG06_309 ENOG4105F0I Aminotransferase BG06_3096 ENOG4105JVQ RNA Polymerase BG06_3098 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BG06_31 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BG06_310 ENOG4108MES Periplasmic binding protein BG06_3101 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BG06_3108 ENOG4105VEQ Cold shock protein BG06_3110 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BG06_3111 ENOG4105E4F Isochorismate synthase BG06_3113 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BG06_3114 ENOG4108IPT Naphthoate synthase BG06_3116 ENOG4105DTQ mandelate racemase muconate lactonizing BG06_3120 ENOG41069H0 dihydroorotase EC 3.5.2.3 BG06_3124 ENOG4105FDP GntR family transcriptional regulator BG06_3126 ENOG4105C6Z Gluconate BG06_3134 ENOG41086D8 Transcriptional regulator BG06_3135 ENOG4105C19 ABC transporter BG06_314 ENOG4105CAQ asparagine synthetase BG06_3140 ENOG4107ZTW SNARE associated Golgi BG06_3143 ENOG4105C19 ABC transporter BG06_3148 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BG06_3149 ENOG4108UGV hypoxanthine phosphoribosyltransferase BG06_315 ENOG4107Y70 Heat shock protein BG06_3154 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG06_3155 ENOG4105BZU Histidine kinase BG06_316 ENOG4108KF3 Electron transport protein SCO1 SenC BG06_3160 ENOG41087YS Phage shock protein A BG06_317 ENOG4105E8R UPF0173 metal-dependent hydrolase BG06_3171 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BG06_3172 ENOG4105C4M (Ubiquinol oxidase) subunit I BG06_3174 ENOG4108V2W Carbonate dehydratase BG06_318 ENOG4108RCR degv family BG06_3184 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BG06_3186 ENOG4105D2X ABC transporter substrate-binding protein BG06_3189 ENOG4107T7U Sulfatase BG06_3190 ENOG4107S9D Alpha beta hydrolase BG06_3191 ENOG4105BZU Histidine kinase BG06_3192 ENOG4105BZU Histidine kinase BG06_3193 ENOG4105EGD dinuclear metal center protein, YbgI family BG06_320 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BG06_3201 ENOG4108MK9 spermidine N(1)-acetyltransferase BG06_3203 ENOG4108RIR Molybdenum cofactor biosynthesis protein BG06_3205 ENOG4105BZF Glycosyl transferase (Group 1 BG06_3206 ENOG4105YVM Phosphoesterase, PA-phosphatase related BG06_3207 ENOG4108Z0R Transferase BG06_3208 ENOG4105E8V Alpha Beta Hydrolase Fold protein BG06_3217 ENOG4105CIG ABC transporter BG06_3219 ENOG4105N5T Radical SAM Protein BG06_322 ENOG4108UT2 hemolysin iii BG06_3223 ENOG4105C19 ABC transporter BG06_3226 ENOG4105NCW Trka-c domain protein BG06_3227 ENOG4107S91 Sodium hydrogen exchanger BG06_3228 ENOG410605W Major Facilitator BG06_323 ENOG4105E9Q Acyl-transferase BG06_3234 ENOG4108B31 Spore germination protein BG06_3236 ENOG4105DWV Homoserine O-trans-acetylase BG06_3238 ENOG41085GJ domain protein BG06_3242 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BG06_3243 ENOG4105D06 uba thif-type nad fad binding protein BG06_3245 ENOG4105CVM Molybdenum cofactor synthesis domain protein BG06_3246 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BG06_3247 ENOG4108ZAF Molybdopterin BG06_3251 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BG06_3252 ENOG4108VJ1 Transcriptional regulator (CarD family BG06_3259 ENOG4105CBX hi0933 family BG06_3262 ENOG4105YW5 deoR family transcriptional regulator BG06_3263 ENOG4107QSE Dipeptidase BG06_3265 ENOG4108IUM Glycogen debranching enzyme BG06_3266 ENOG4108V15 phosphotransferase enzyme family BG06_3269 ENOG4105C8F Beta-lactamase domain protein BG06_327 ENOG4107RVG penicillin-binding protein BG06_3275 ENOG4108VDD TRNA binding domain protein BG06_3281 ENOG4105K7K Transcriptional regulator BG06_3285 ENOG4105C88 aminopeptidase BG06_3289 ENOG4105ETE Transcriptional regulator (LacI family BG06_3295 ENOG4105EP9 oxidoreductase BG06_3296 ENOG4107SNB ankyrin repeat protein YahD BG06_3298 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG06_3301 ENOG4105DGU Histone deacetylase BG06_3302 ENOG4105W87 Cbs domain BG06_3303 ENOG4105F1V Acetoin utilization protein BG06_3307 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BG06_331 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BG06_3311 ENOG4105C28 cystathionine BG06_3313 ENOG4105U5Y Transcriptional regulator BG06_3315 ENOG4106KR7 LysR family Transcriptional regulator BG06_3320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BG06_3322 ENOG4105EFZ amidohydrolase BG06_3325 ENOG4105KBJ sporulation protein ytfj BG06_3326 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BG06_3332 ENOG4108JYZ YitT family BG06_334 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BG06_3341 ENOG4107YZX Universal stress protein BG06_3345 ENOG41082W1 Cupin 2, conserved barrel domain protein BG06_3346 ENOG4105Z7P Acetyltransferase (GNAT) family BG06_3356 ENOG4105DC7 peptidase M24 BG06_3364 ENOG4105SFS phosphoesterase RecJ domain protein BG06_3366 ENOG4105VV2 BG06_3367 ENOG4105C0B DNA polymerase III (alpha subunit) BG06_3368 ENOG4105C6K Malic enzyme BG06_3369 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BG06_3374 ENOG4105FS0 cytoplasmic membrane protein BG06_3375 ENOG4108REF Sporulation integral membrane protein ytvi BG06_3377 ENOG4105BZN citrate synthase BG06_3378 ENOG4108HMX isocitrate dehydrogenase (NADP) BG06_3383 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG06_3384 ENOG4105BZU Histidine kinase BG06_3385 ENOG4105C2M dna polymerase I BG06_3386 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BG06_3389 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BG06_339 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BG06_3390 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BG06_3394 ENOG4108TDW sporulation protein YtxC BG06_3395 ENOG4105C22 threonyL-tRNA synthetase BG06_3396 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BG06_34 ENOG4108VXD carboxy-peptidase BG06_340 ENOG4105KD7 acetyltransferase BG06_3400 ENOG4105CN9 Peptidase m42 family protein BG06_3401 ENOG4108JGH Tetr family transcriptional regulator BG06_3402 ENOG4105CW7 secretion protein, HlyD family BG06_3403 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG06_3407 ENOG4108RWN rrna methyltransferase BG06_3409 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BG06_3417 ENOG4105DCG PHP domain protein BG06_3420 ENOG4105FE9 pseudouridine synthase BG06_3422 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BG06_3423 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BG06_3426 ENOG4105E0A ABC, transporter BG06_3427 ENOG4105KFN sortase, SrtB family BG06_343 ENOG4105C0A alcohol dehydrogenase BG06_3430 ENOG4105DR4 Methyltransferase BG06_3433 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG06_344 ENOG4105CY2 Citrate transporter BG06_3441 ENOG4105S6R Iron-hydroxamate transporter permease subunit BG06_3442 ENOG4105J76 Periplasmic binding protein BG06_3444 ENOG4105CEY Amp-dependent synthetase and ligase BG06_3445 ENOG4107Z3H Transcriptional regulator, TetR family BG06_3446 ENOG41060WC Enoyl-CoA hydratase BG06_3447 ENOG4105BZJ Electron transfer flavoprotein BG06_3448 ENOG4105C10 Electron transfer flavoprotein BG06_3449 ENOG4105K63 Thioredoxin BG06_345 ENOG4107XGZ Hydrolase BG06_3452 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BG06_3454 ENOG4105E33 succinate dehydrogenase BG06_3456 ENOG4108VXD carboxy-peptidase BG06_3457 ENOG4105E14 MotA TolQ exbB proton channel BG06_3458 ENOG4105ER2 Ompa motb domain protein BG06_3459 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BG06_3460 ENOG4108IUX (ABC) transporter BG06_3461 ENOG4105RHA ABC transporter, permease BG06_3462 ENOG4108Z40 Transcriptional regulator BG06_3463 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BG06_3465 ENOG4108JCI Transcriptional regulator BG06_3466 ENOG41067S9 phage shock protein C, PspC BG06_3468 ENOG4105DY9 regulatoR BG06_3469 ENOG4108HRK Histidine kinase BG06_3470 ENOG4108JQ7 (ABC) transporter BG06_3473 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG06_3474 ENOG4105DEF Extracellular solute-binding protein, family 5 BG06_3475 ENOG4105DZC cytosine deaminase BG06_3476 ENOG4105DZC cytosine deaminase BG06_3479 ENOG4105PFC Transcriptional regulator BG06_3482 ENOG4105KBX Transcriptional regulator, TetR family BG06_3484 ENOG4108PCX Major Facilitator BG06_3486 ENOG4108XJQ germination protein BG06_3488 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BG06_3489 ENOG4105M59 Phosphodiesterase, mj0936 family BG06_349 ENOG4105C8J )-transporter BG06_3497 ENOG4108QCI YvbH-like oligomerisation region BG06_350 ENOG4105C5S asparaginyl-tRNA synthetase BG06_3504 ENOG4108IUQ atp-dependent protease BG06_3508 ENOG4105K56 Transcriptional regulator BG06_351 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BG06_3513 ENOG4105D52 delta-aminolevulinic acid dehydratase BG06_3515 ENOG41068KH stage VI sporulation protein D BG06_3518 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BG06_3522 ENOG4105DFF Rod shape-determining protein mreb BG06_3523 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BG06_3526 ENOG4107QMS site-determining protein BG06_3529 ENOG4105C03 ribonuclease BG06_3531 ENOG4105X36 (ribosomal) protein BG06_3536 ENOG4105EWM Histidine kinase BG06_3540 ENOG4105CQC Prephenate dehydratase BG06_3541 ENOG4108RPX mosc domain containing protein BG06_3544 ENOG4108IYU L-aspartate oxidase BG06_3545 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BG06_3550 ENOG41082BM Transcriptional regulator, arsr family BG06_3551 ENOG4108IPJ Membrane BG06_3553 ENOG4108HUF Transporter BG06_3556 ENOG41061AI Protein of unknown function (DUF2905) BG06_3559 ENOG4105VIE preprotein translocase, subunit YajC BG06_3561 ENOG4108QG2 Membrane BG06_3562 ENOG4105CKP Polysaccharide Biosynthesis Protein BG06_3564 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BG06_3565 ENOG41076HS cation diffusion facilitator family transporter BG06_3566 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BG06_3568 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BG06_3571 ENOG4105CUT histidyl-tRNA synthetase BG06_3573 ENOG4105CUZ uba thif-type nad fad binding protein BG06_3574 ENOG4108VCI transcription factor, rsfa family BG06_3575 ENOG4105D1H recombination factor protein RarA BG06_3577 ENOG4105C3J Cysteine desulfurase BG06_358 ENOG4107YX5 Pfam:DUF548 BG06_3580 ENOG4105C7H Helicase, RecD TraA family BG06_3581 ENOG41060CR BG06_3584 ENOG4105C02 permease BG06_3590 ENOG4105HHA aminodeoxychorismate lyase BG06_3591 ENOG4108VQJ O-methyltransferase BG06_3592 ENOG4105XYU peptidase (U32 family) BG06_3593 ENOG4105CFP Peptidase U32 BG06_3596 ENOG4107XRG penicillin-binding protein BG06_3602 ENOG4105C28 cystathionine BG06_3603 ENOG4108EKI Dehydrogenase BG06_3605 ENOG4108V5C ABC transporter BG06_3606 ENOG4105S6R Iron-hydroxamate transporter permease subunit BG06_3614 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BG06_3616 ENOG4105MIR Phenylalanine 4-monooxygenase BG06_3617 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BG06_3624 ENOG4108MUZ hydrolase BG06_3626 ENOG4105G6Z alkaline phosphatase BG06_3629 ENOG4108TVJ Nitroreductase BG06_3635 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG06_3638 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BG06_3639 ENOG4105CQW ribosome biogenesis GTPase YqeH BG06_364 ENOG4108UUM single-stranded DNA-binding protein BG06_3641 ENOG410812S Rna-binding protein BG06_3643 ENOG4108WF2 Metal Dependent Phosphohydrolase BG06_3645 ENOG4105DXX methyltransferase BG06_3647 ENOG4105KQC Competence protein BG06_3648 ENOG4108UK2 deaminase BG06_3649 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BG06_3651 ENOG4105TQK DNA polymerase iii, delta' subunit BG06_3656 ENOG4105KVH Transcriptional regulator BG06_3657 ENOG4105CSA Coproporphyrinogen iii oxidase BG06_3659 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BG06_3663 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BG06_3664 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BG06_3666 ENOG4105KTH gatB Yqey BG06_3667 ENOG41068P3 sporulation protein YqfC BG06_3669 ENOG4105C9A Phoh family BG06_367 ENOG4105C5H ABC transporter BG06_3670 ENOG4105CTJ Metal Dependent Phosphohydrolase BG06_3672 ENOG4107YR5 Diacylglycerol kinase BG06_3673 ENOG4105KG3 cytidine deaminase BG06_3674 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BG06_3679 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BG06_3680 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG06_3683 ENOG4105EGD dinuclear metal center protein, YbgI family BG06_3688 ENOG41069ZM Protein of unknown function (DUF2624) BG06_3689 ENOG4108JYZ YitT family BG06_3690 ENOG4105FDK ABC transporter BG06_3692 ENOG4105N80 Ferric uptake regulator, Fur family BG06_3697 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG06_3699 ENOG4107RF6 penicillin-binding protein BG06_37 ENOG4105VZ8 Transcriptional regulator BG06_3700 ENOG4105PWN phosphate abc transporter BG06_3701 ENOG4105C8U phosphate abc transporter BG06_3702 ENOG4105E2Z phosphate ABC transporter (Permease BG06_3703 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BG06_3704 ENOG4108UTW Plays a role in the regulation of phosphate uptake BG06_3707 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BG06_3709 ENOG4105DKQ ROK family BG06_3711 ENOG4105C5X domain protein BG06_3715 ENOG4105C28 cystathionine BG06_3716 ENOG4105C28 cystathionine BG06_3718 ENOG4105C3R Methionine synthase BG06_372 ENOG4105MCT stage V sporulation protein S BG06_3742 ENOG4105C0D helicase BG06_3748 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BG06_3756 ENOG41080TC multidrug resistance protein BG06_3760 ENOG4105WZW rhodanese family BG06_3761 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BG06_3769 ENOG4107YBY Hydrolase BG06_3770 ENOG4105CBJ Metal-dependent enzyme BG06_3773 ENOG4105DC7 peptidase M24 BG06_3778 ENOG4105CD2 stage iii sporulation protein aa BG06_3779 ENOG4105KR5 Stage iii sporulation protein BG06_3780 ENOG4108CQH stage III sporulation protein AC BG06_3781 ENOG4105KQ4 Stage iii sporulation protein ad BG06_3783 ENOG410644B Stage III sporulation protein af BG06_3788 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BG06_3789 ENOG4108ZSR alkaline shock protein BG06_379 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BG06_3794 ENOG4105CTB Polyprenyl synthetase BG06_3796 ENOG4105DX0 Hemolysin A BG06_3798 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BG06_3799 ENOG4105S1Z Stage IV sporulation protein B BG06_380 ENOG4108IFG nitrite reductase, (NAD(P)H) BG06_3800 ENOG4107QQR Sporulation BG06_3803 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BG06_3805 ENOG4108JUB Transcriptional regulator BG06_3807 ENOG4107RDP Dehydrogenase BG06_381 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BG06_3811 ENOG4105CPP Dehydrogenase, E1 component BG06_3812 ENOG4105C7S Dehydrogenase BG06_3814 ENOG4105E09 nadh pyrophosphatase BG06_3815 ENOG4105G7B Protein of unknown function (DUF2992) BG06_3817 ENOG4108HW3 (ABC) transporter BG06_3818 ENOG4105E5Q amino acid AbC transporter BG06_3819 ENOG4105CDA abc transporter atp-binding protein BG06_382 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BG06_3820 ENOG4108QEG Membrane BG06_3821 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BG06_3823 ENOG4105D9U N-acetyltransferase BG06_3824 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BG06_3826 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BG06_383 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BG06_3830 ENOG4105EJQ L-serine dehydratase BG06_3831 ENOG4105II7 pyrroline-5-carboxylate reductase BG06_3832 ENOG41069FQ Metallo-beta-lactamase superfamily BG06_3833 ENOG4108IXY short-chain dehydrogenase reductase BG06_384 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BG06_3850 ENOG4105CGH 5'-nucleotidase BG06_3851 ENOG4105DFD Na H antiporter BG06_3853 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG06_3856 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BG06_3857 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BG06_3858 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BG06_3862 ENOG4108R6K riboflavin synthase, subunit alpha BG06_3863 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BG06_3867 ENOG4108YM7 Gcn5-related n-acetyltransferase BG06_3868 ENOG4105ETE Transcriptional regulator (LacI family BG06_3870 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BG06_3874 ENOG4105RHY Pfam:UPF0157 BG06_3876 ENOG4105CPC Aldo Keto reductase BG06_388 ENOG4108ZAF Molybdopterin BG06_3882 ENOG4105MZ9 stage II sporulation protein m BG06_3883 ENOG4105I3K Ferric uptake regulator, Fur family BG06_3885 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG06_389 ENOG4105CVM Molybdenum cofactor synthesis domain protein BG06_3890 ENOG4105D7N magnesium and cobalt transport protein CorA BG06_3897 ENOG4105DVE abc transporter atp-binding protein BG06_3898 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BG06_3899 ENOG4105DZ1 carboxypeptidase BG06_39 ENOG4105CGH 5'-nucleotidase BG06_390 ENOG4105D06 uba thif-type nad fad binding protein BG06_3900 ENOG41082AN stage II sporulation protein BG06_3902 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG06_3903 ENOG4105C8J )-transporter BG06_3907 ENOG41090VF Stage v sporulation protein ac BG06_3908 ENOG4105CZ3 stage V sporulation protein ad BG06_391 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BG06_3910 ENOG4105G6R Stage v sporulation protein ae BG06_3912 ENOG4105J7I hydrolase BG06_3913 ENOG4105PTM secreted protein BG06_3914 ENOG4107ZE5 PPIases accelerate the folding of proteins BG06_392 ENOG4107V6Q Cyclic nucleotide-binding domain BG06_3921 ENOG4105CE4 GlcNAc 6-P deacetylase BG06_3923 ENOG4105FDP GntR family transcriptional regulator BG06_3925 ENOG4105CID antiterminator BG06_3928 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BG06_3932 ENOG4106TD9 Diguanylate cyclase BG06_3933 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BG06_394 ENOG4105R3A Nitrate reductase BG06_3941 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BG06_3945 ENOG4105DTD Dehydrogenase BG06_3946 ENOG4105K7K Transcriptional regulator BG06_395 ENOG4108IUE nitrate reductase beta subunit BG06_3953 ENOG4105CHU acetyl-coa acetyltransferase BG06_3963 ENOG4105CG3 alpha amylase, catalytic region BG06_3965 ENOG4107FKK extracellular solute-binding protein family 1 BG06_3967 ENOG4105EG2 ABC transporter, permease BG06_3968 ENOG4105FKQ transcriptional regulator BG06_3969 ENOG4105CHM Aminotransferase BG06_397 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BG06_3971 ENOG4108HGU Histidine kinase BG06_3982 ENOG4105UIN BG06_3984 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BG06_3987 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BG06_3988 ENOG4105EPM Diguanylate phosphodiesterase BG06_3991 ENOG4107IN1 Protein of unknown function (DUF1797) BG06_3993 ENOG4108XRC Protein of unknown function (DUF458) BG06_4 ENOG4105DZ1 carboxypeptidase BG06_400 ENOG4108V06 Glutathione peroxidase BG06_4000 ENOG4107ZYR domain protein BG06_4001 ENOG4105CN5 Metallo-Beta-Lactamase BG06_4003 ENOG4108X4Q Hydrolase BG06_4004 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BG06_4007 ENOG4105CPP Dehydrogenase, E1 component BG06_4017 ENOG4105CXN decarboxylase BG06_402 ENOG4105CNW domain protein BG06_4021 ENOG4105ECY inositol monophosphatase BG06_4023 ENOG4105CI3 gtp-binding protein typa BG06_4024 ENOG4105QA2 BG06_4028 ENOG4108IAB Phoh family BG06_4034 ENOG4105CNI cell division protein FtsW BG06_4035 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BG06_4045 ENOG4106UY4 Inherit from COG: Scp-like extracellular BG06_4048 ENOG4107TB6 phosphoglycerate mutase BG06_405 ENOG4105EMN RNA polymerase sigma factor BG06_4052 ENOG4106H78 methyltransferase BG06_4053 ENOG4105H20 Sporulation integral membrane protein YlbJ BG06_4055 ENOG4105D78 K07001 NTE family protein BG06_4056 ENOG41063PX domain protein BG06_4058 ENOG4105KNH Nucleic acid-binding protein BG06_406 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BG06_4065 ENOG41068DC Essential cell division protein (By similarity) BG06_4066 ENOG4105CJN penicillin-binding protein BG06_4067 ENOG4105CJN penicillin-binding protein BG06_4068 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BG06_4071 ENOG4105CNI cell division protein FtsW BG06_4074 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BG06_4075 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BG06_4076 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BG06_4078 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG06_408 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BG06_4080 ENOG4105WR5 sporulation protein, YlmC YmxH family BG06_4081 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BG06_4082 ENOG4105DFA alanine racemase domain protein BG06_4084 ENOG41067XK integral membrane protein BG06_4085 ENOG4105DBK s4 domain protein BG06_409 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BG06_4090 ENOG4105C34 Pseudouridine synthase BG06_4095 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BG06_4107 ENOG4105DC7 peptidase M24 BG06_4108 ENOG4105F23 Fibronectin-binding protein BG06_4110 ENOG4105DSJ YicC domain protein BG06_4114 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BG06_4115 ENOG4105C25 Primosomal protein n' BG06_4116 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BG06_4118 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BG06_4120 ENOG4108ZF3 Phosphatase BG06_4121 ENOG4105D9P serine threonine protein kinase BG06_4122 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BG06_4123 ENOG4105DJV ribulose-phosphate 3-epimerase BG06_4124 ENOG4105FJ0 thiamine BG06_4126 ENOG4108ZAA Alkaline-shock protein BG06_4127 ENOG4105DP4 dak2 domain fusion protein ylov BG06_4128 ENOG4105CB5 ATP-dependent DNA helicase recG BG06_413 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BG06_4131 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BG06_4132 ENOG4105CHR reductase BG06_4135 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BG06_4136 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BG06_4140 ENOG4105VB6 UPF0109 protein BG06_4145 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BG06_4148 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BG06_4149 ENOG4105C79 DNA protecting protein DprA BG06_4150 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BG06_4152 ENOG4108HE4 integrase family BG06_4161 ENOG4105KNE Phosphatidate cytidylyltransferase BG06_4163 ENOG4105DZP Membrane-associated zinc metalloprotease BG06_4165 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BG06_4167 ENOG4105CHV Transcription elongation factor NusA BG06_4168 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BG06_4169 ENOG4105VHM ribosomal protein BG06_4171 ENOG4105W7A Protein of unknown function (DUF503) BG06_4174 ENOG4105DTN riboflavin biosynthesis protein ribF BG06_4178 ENOG4105C1V Peptidase, M16 BG06_418 ENOG4105KBJ sporulation protein ytfj BG06_4180 ENOG4105E35 Dipicolinate synthase subunit A BG06_4181 ENOG4108S0H Dipicolinic acid synthetase, b subunit BG06_4182 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BG06_4184 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG06_4186 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BG06_4188 ENOG4107QZI cell division protein FtsK BG06_4189 ENOG4105FDP GntR family transcriptional regulator BG06_4190 ENOG4105DIH basic membrane BG06_4191 ENOG4108JQ9 ABC transporter BG06_4192 ENOG4105UIB (ABC) transporter BG06_4196 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BG06_4197 ENOG4105XZV Protein of unknown function (DUF3243) BG06_42 ENOG4105DH8 myo-inositol catabolism BG06_4200 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BG06_4205 ENOG4105D48 metallophosphoesterase BG06_4206 ENOG4105MCT stage V sporulation protein S BG06_4207 ENOG4108IGT Dipeptidase BG06_4208 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BG06_4209 ENOG4105DQU oxidoreductase, subunit beta BG06_4215 ENOG4107QHE Choloylglycine hydrolase BG06_4217 ENOG410890F Dynamin family BG06_4218 ENOG4105E0M Sulfatase BG06_4219 ENOG4107R6R udp-galactopyranose mutase BG06_4220 ENOG4105F0V Cell wall hydrolase BG06_4228 ENOG4105BZU Histidine kinase BG06_4229 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BG06_4235 ENOG4105D03 DNA-3-methyladenine glycosylase II BG06_4236 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BG06_4238 ENOG4105CGK Exodeoxyribonuclease III BG06_4242 ENOG4105E0A ABC, transporter BG06_4243 ENOG4105NIV Esterase BG06_4245 ENOG4105VPX protein, conserved in bacteria BG06_4246 ENOG410681U heavy metal transport detoxification protein BG06_4247 ENOG4105C59 p-type ATPase BG06_4249 ENOG4105K70 DNA-binding protein BG06_4250 ENOG4105TMB Formate nitrite transporter BG06_4254 ENOG4105C85 amino acid BG06_4257 ENOG4108SJC Membrane BG06_4258 ENOG4107QW4 alcohol dehydrogenase BG06_4259 ENOG4105E98 transcriptional regulator DeoR family BG06_4260 ENOG4105DE4 1-phosphofructokinase BG06_4261 ENOG4105DM4 PTS System BG06_4262 ENOG41069ER domain protein BG06_4268 ENOG4106F1P AAA ATPase, central domain protein BG06_4270 ENOG4105EN6 Membrane BG06_4271 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BG06_4272 ENOG4105CXI aluminum resistance protein BG06_4273 ENOG4105KV4 Transcriptional regulator BG06_4274 ENOG4105C5F glutamine synthetase BG06_4275 ENOG4105K7K Transcriptional regulator BG06_4279 ENOG4108SVB resolvase BG06_4281 ENOG4105CGH 5'-nucleotidase BG06_4286 ENOG4105D7V transposase BG06_4290 ENOG4105BZ1 (ABC) transporter BG06_4291 ENOG4105BZ1 (ABC) transporter BG06_4299 ENOG41067MG lrgb family BG06_43 ENOG4105D2N Aldolase BG06_4301 ENOG4107RSM transcriptional regulator BG06_4303 ENOG4105CJ1 ABC, transporter BG06_4305 ENOG4105CH2 amidohydrolase BG06_4307 ENOG4107QIV Cytochrome c biogenesis protein BG06_4316 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BG06_4321 ENOG4108903 Formimidoylglutamase BG06_4322 ENOG4108VJ1 Transcriptional regulator (CarD family BG06_4325 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BG06_4326 ENOG4105CBC glutamate synthase BG06_4327 ENOG4105CK7 Sodium proline symporter BG06_4328 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BG06_4329 ENOG4105FBA Phospholipase Carboxylesterase BG06_433 ENOG4108MGT Required for secretion of EsxA and EsxB BG06_4330 ENOG4105BZU Histidine kinase BG06_4332 ENOG4107AYK membrAne BG06_434 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) BG06_4341 ENOG4105CEY Amp-dependent synthetase and ligase BG06_4342 ENOG4107ZYJ bioY protein BG06_4343 ENOG4107F3J Amp-dependent synthetase and ligase BG06_4347 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BG06_4349 ENOG4105E5W Transporter BG06_4355 ENOG4108I0Z Aconitate hydratase BG06_4356 ENOG4108JJA ABC, transporter BG06_4358 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG06_4359 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BG06_436 ENOG4106PAW secretion accessory protein EsaA YueB BG06_4365 ENOG4105W8X HesB YadR YfhF-family protein BG06_4367 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BG06_4369 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG06_4370 ENOG4105C0H protease BG06_4371 ENOG4105K4P CoA-binding domain protein BG06_4372 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG06_4374 ENOG4105D9R oxidoreductase BG06_4376 ENOG4105CIG ABC transporter BG06_4378 ENOG4105EMN RNA polymerase sigma factor BG06_4380 ENOG4108KGH TRANSCRIPTIONal BG06_4381 ENOG4107QJT sodium dicarboxylate symporter BG06_4384 ENOG4105DQ6 Transposase BG06_4396 ENOG4105E1K spore germination protein BG06_4397 ENOG4108JB9 formate dehydrogenase BG06_4399 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BG06_4400 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BG06_4402 ENOG4105TMB Formate nitrite transporter BG06_4403 ENOG4105D06 uba thif-type nad fad binding protein BG06_4404 ENOG4105CVM Molybdenum cofactor synthesis domain protein BG06_4405 ENOG4108ZAF Molybdopterin BG06_4407 ENOG4105D1F ATP-binding protein BG06_441 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BG06_4410 ENOG410696E Membrane BG06_4411 ENOG4105FR1 rard protein BG06_4413 ENOG4105EWU Squalene--hopene cyclase BG06_4415 ENOG4105CHR reductase BG06_4416 ENOG4105C26 Dehydrogenase BG06_4418 ENOG4108IA2 Sodium pantothenate symporter BG06_4421 ENOG4106IQC argininosuccinate lyase BG06_4423 ENOG410904N short-chain dehydrogenase reductase BG06_4427 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BG06_4431 ENOG4105VEQ Cold shock protein BG06_4435 ENOG4108R1P BG06_4437 ENOG41073R8 VanW family BG06_4438 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BG06_4441 ENOG4105KT7 mgtC SapB transporter BG06_4443 ENOG4105E39 Enoyl-CoA hydratase BG06_4444 ENOG4105K64 Glycosyl transferase, family 2 BG06_4446 ENOG4108UT6 Transferase hexapeptide repeat containing protein BG06_4450 ENOG4105CQB FAD linked oxidase domain protein BG06_4451 ENOG4105C09 Bile acid BG06_4456 ENOG4105CIS alcohol dehydrogenase BG06_4457 ENOG41082BM Transcriptional regulator, arsr family BG06_4459 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BG06_4465 ENOG4108A04 Beta-lactamase BG06_4466 ENOG4105DPN Oligoendopeptidase f BG06_4467 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BG06_4468 ENOG4105E5K Alpha-amylase BG06_4470 ENOG4105C98 muts2 protein BG06_4474 ENOG4107V2S Transcriptional regulator BG06_4476 ENOG4107CUJ Protein of unknown function (DUF2690) BG06_448 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG06_4480 ENOG4107ZY0 Phenazine biosynthesis-like protein BG06_4481 ENOG4105NX3 Membrane BG06_4482 ENOG4105DQ5 transport system permease protein BG06_4483 ENOG4105EHG Permease protein BG06_4484 ENOG4108MES Periplasmic binding protein BG06_4486 ENOG4107R3E Citrate transporter BG06_4488 ENOG4108TN2 lmbE family BG06_449 ENOG4108JYZ YitT family BG06_4493 ENOG4105CBK multidrug resistance protein BG06_4495 ENOG4105CIS alcohol dehydrogenase BG06_450 ENOG41087PP glycosyltransferase MGT family BG06_4502 ENOG4105H3G oxidoreductase BG06_4509 ENOG4107YXZ hydrolase, family 25 BG06_4513 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BG06_4518 ENOG4105KAF membrAne BG06_4528 ENOG4108ZJ4 polysaccharide deacetylase BG06_453 ENOG4107RBS Methyltransferase BG06_4530 ENOG4105KVH Transcriptional regulator BG06_4531 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BG06_4534 ENOG4105CHR reductase BG06_4536 ENOG4105JAB phenazine biosynthesis protein, phzf family BG06_454 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BG06_4543 ENOG4105KVH Transcriptional regulator BG06_4544 ENOG4105KVH Transcriptional regulator BG06_4545 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BG06_4546 ENOG4105D9R oxidoreductase BG06_4547 ENOG4108TZY GntR Family Transcriptional Regulator BG06_4554 ENOG4105C44 Serine transporter BG06_456 ENOG4108X4Q Hydrolase BG06_4561 ENOG4105D4Y metalloprotease BG06_4562 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BG06_4564 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BG06_4566 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BG06_4569 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BG06_4570 ENOG4105C6Z Gluconate BG06_4571 ENOG4105CMG Carbohydrate kinase BG06_4572 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BG06_4573 ENOG4105XDF Protein of unknown function (DUF1272) BG06_4574 ENOG4105DDN Pentapeptide repeat-containing protein BG06_4577 ENOG4105C37 (CBS) domain BG06_4583 ENOG4105EV4 Multidrug resistance protein mdtH BG06_4585 ENOG4105DMQ Methyltransferase BG06_4591 ENOG4105C31 Tryptophanyl-tRNA synthetase BG06_4593 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BG06_4595 ENOG4108UW5 maltose o-acetyltransferase BG06_4596 ENOG4105DKQ ROK family BG06_4597 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BG06_4608 ENOG4105CJ1 ABC, transporter BG06_461 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BG06_4610 ENOG4108PSK reductase BG06_4614 ENOG4108RCM Nitroreductase BG06_4615 ENOG4105KVH Transcriptional regulator BG06_4619 ENOG4108Z66 YbaK ebsC protein BG06_462 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BG06_4624 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BG06_4629 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BG06_463 ENOG4108VXD carboxy-peptidase BG06_4636 ENOG4105DYS nad(p)h dehydrogenase (quinone) BG06_4638 ENOG4105CRW Short chain fatty acid transporter BG06_4640 ENOG4107AUC BG06_4641 ENOG4105KBX Transcriptional regulator, TetR family BG06_4642 ENOG4105KPY Small multidrug resistance protein BG06_4643 ENOG4105RXJ BG06_4645 ENOG41069JR BG06_4646 ENOG4105DA5 (ABC) transporter BG06_465 ENOG4108ZRV stage ii sporulation protein p BG06_4650 ENOG4105CZM Major Facilitator BG06_4651 ENOG4107MII Sugar-specific transcriptional regulator TrmB BG06_4653 ENOG4108ISG Major Facilitator BG06_4672 ENOG4106YAD MORN repeat variant BG06_468 ENOG4108Z7R Chaperone CsaA BG06_4705 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BG06_4708 ENOG410874W AraC family transcriptional regulator BG06_4709 ENOG41082W1 Cupin 2, conserved barrel domain protein BG06_4712 ENOG4108AEY RNA polymerase sigma factor BG06_4716 ENOG4108JQ1 Dehydrogenase BG06_472 ENOG4105C37 (CBS) domain BG06_4720 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BG06_4724 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BG06_4726 ENOG4105BZU Histidine kinase BG06_4729 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BG06_473 ENOG4105SXS Protein of unknown function (DUF456) BG06_4730 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BG06_4733 ENOG4105JQZ Methyltransferase BG06_4734 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BG06_4736 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BG06_4745 ENOG4105K6H D-cysteine desulfhydrase BG06_4752 ENOG4105IIP Membrane BG06_4755 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG06_4756 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BG06_4765 ENOG4108YXU transcriptional regulator AsnC family BG06_4766 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BG06_4767 ENOG4108IG5 Transcriptional regulator BG06_4768 ENOG4107P5I polyketide synthase BG06_477 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG06_4771 ENOG41085FC arsR family transcriptional regulator BG06_4772 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BG06_4773 ENOG4105D6J arsenicaL-resistance protein BG06_4778 ENOG4108NEV two component transcriptional regulator, LytTR family BG06_478 ENOG4108S4H thioesterase Superfamily protein BG06_4781 ENOG4105C19 ABC transporter BG06_4785 ENOG4105E5W Transporter BG06_4788 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BG06_4796 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BG06_4799 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BG06_48 ENOG4105CK5 oxidoreductase BG06_480 ENOG4108PJD permease BG06_4800 ENOG4108TWJ NADH dehydrogenase subunit 5 BG06_4803 ENOG4105CVP deoxyribo-dipyrimidine photolyase BG06_4804 ENOG4108606 TspO/MBR family BG06_4809 ENOG4105DWP Membrane BG06_4810 ENOG4105DUM transcriptional regulator, lysR family BG06_4822 ENOG4105CHJ isochorismatase hydrolase BG06_4824 ENOG4105CH6 catalase BG06_4825 ENOG4105CGH 5'-nucleotidase BG06_483 ENOG4107T5V SNARE associated Golgi BG06_4832 ENOG4105CSV Glutaminase BG06_4836 ENOG4108Q8B Spore germination protein BG06_4837 ENOG4108NHD germination protein BG06_4840 ENOG4105II7 pyrroline-5-carboxylate reductase BG06_4842 ENOG4105CUB amino acid BG06_4843 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BG06_4844 ENOG4105YWU small acid-soluble spore protein BG06_4845 ENOG41075H3 AraC family transcriptional regulator BG06_4850 ENOG4105BZU Histidine kinase BG06_4852 ENOG4108B31 Spore germination protein BG06_4854 ENOG4108IMY Transcriptional regulator BG06_4855 ENOG4105HDK L-asparaginase BG06_4856 ENOG4108IJ0 Aspartate ammonia-lyase BG06_4858 ENOG4105E2A Dehydrogenase BG06_487 ENOG4107TB6 phosphoglycerate mutase BG06_4873 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BG06_4881 ENOG4105DWD nucleoside recognition domain protein BG06_4885 ENOG4105FDT acyl-CoA dehydrogenase BG06_4887 ENOG4108ZHR arsR family transcriptional regulator BG06_4888 ENOG4108ZRV stage ii sporulation protein p BG06_4890 ENOG4106N3A copper homeostasis protein cutc BG06_4892 ENOG4107258 Transcriptional regulator BG06_4893 ENOG4105P4J Allophanate hydrolase, subunit 1 BG06_49 ENOG4105IE8 Alpha-ketoglutarate permease BG06_4901 ENOG4107RF6 penicillin-binding protein BG06_4907 ENOG4105F1N DNA alkylation repair BG06_4909 ENOG4108IQI permease BG06_4910 ENOG4105KNA -acetyltransferase BG06_4911 ENOG410635A Membrane BG06_492 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BG06_4927 ENOG4108XET gCN5-related N-acetyltransferase BG06_4933 ENOG4105C19 ABC transporter BG06_4937 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BG06_494 ENOG4105K4T epimerase BG06_4944 ENOG4105FS7 Transcriptional regulator BG06_4945 ENOG4108TVJ Nitroreductase BG06_4949 ENOG4108IBT Inherit from COG: transposase BG06_4957 ENOG4106BHF BG06_4958 ENOG4106BHF BG06_4959 ENOG41090AA BG06_496 ENOG4105DSE periplasmic solute binding protein BG06_4970 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BG06_498 ENOG4105CKI cobalamin synthesis protein BG06_4980 ENOG4105C8Y Acetylornithine aminotransferase BG06_4982 ENOG4105CKK Glycosyl transferase, family 2 BG06_4986 ENOG4105CKK Glycosyl transferase, family 2 BG06_499 ENOG4107QM2 Aldo Keto reductase BG06_4991 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BG06_4997 ENOG4105KNA -acetyltransferase BG06_50 ENOG4105ETE Transcriptional regulator (LacI family BG06_500 ENOG4105VMI -acetyltransferase BG06_5001 ENOG4108WCX response regulator BG06_5003 ENOG41090T1 Membrane BG06_5006 ENOG4105VMP Transcriptional regulator BG06_5008 ENOG4105G6Z alkaline phosphatase BG06_5009 ENOG4105ECK Fatty Acid Desaturase BG06_5010 ENOG4105E0Y RtcB Protein BG06_5012 ENOG4107258 Transcriptional regulator BG06_5014 ENOG4105II7 pyrroline-5-carboxylate reductase BG06_5021 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BG06_5026 ENOG41061GT Aldolase BG06_5028 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BG06_5029 ENOG4105DKT Transcriptional regulator BG06_503 ENOG4105DEN Luciferase family BG06_5031 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BG06_5033 ENOG4105D4B ABC, transporter BG06_5037 ENOG4108JUB Transcriptional regulator BG06_5038 ENOG4105J5T Amp-dependent synthetase and ligase BG06_5039 ENOG4105E39 Enoyl-CoA hydratase BG06_5040 ENOG4105CY2 Citrate transporter BG06_5042 ENOG41069ER domain protein BG06_5049 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BG06_5055 ENOG41082JN Transcriptional regulator BG06_5056 ENOG4105EYF MMPL domain protein BG06_5058 ENOG4105C5H ABC transporter BG06_5059 ENOG4105E0M Sulfatase BG06_506 ENOG4108WPJ Ferritin-like domain BG06_5060 ENOG4108ZCF integral membrane protein BG06_5062 ENOG4107VMI polysaccharide deacetylase BG06_5064 ENOG4107VC0 DNA alkylation repair enzyme BG06_507 ENOG4108K88 Membrane BG06_5074 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BG06_5078 ENOG4105E09 nadh pyrophosphatase BG06_5083 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BG06_5084 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BG06_5085 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BG06_5087 ENOG4105C02 permease BG06_5096 ENOG4105DVE abc transporter atp-binding protein BG06_5099 ENOG4108ZMI UPF0477 protein BG06_51 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BG06_510 ENOG4105C8Q Methyl-accepting chemotaxis BG06_5102 ENOG4105CHM Aminotransferase BG06_5108 ENOG41089UC methyltransferase, type 11 BG06_5111 ENOG4107BMA Transglycosylase associated protein BG06_5115 ENOG4106K7D Major facilitator family transporter BG06_5116 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BG06_5124 ENOG4105EPR degv family BG06_5126 ENOG4105DPN Oligoendopeptidase f BG06_5129 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BG06_5133 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG06_5134 ENOG4105BZU Histidine kinase BG06_5135 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG06_5136 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BG06_5144 ENOG4105DTQ mandelate racemase muconate lactonizing BG06_5147 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BG06_5148 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BG06_515 ENOG4107XZQ multidrug resistance protein BG06_5151 ENOG4107T5V SNARE associated Golgi BG06_5157 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BG06_5159 ENOG41080HI glycine oxidase BG06_516 ENOG4107SET aldo keto reductase BG06_5160 ENOG4105CTU Proline racemase BG06_5161 ENOG4105CTU Proline racemase BG06_5162 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG06_5163 ENOG4105C26 Dehydrogenase BG06_5164 ENOG4105BZG amino acid carrier protein BG06_5168 ENOG4108M1A Chitin-binding protein BG06_517 ENOG4105YVS arsR family transcriptional regulator BG06_5177 ENOG4105C9U ATP-dependent DNA helicase RecQ BG06_5181 ENOG4105EEM helicase BG06_5185 ENOG4108Z7F N-acetyltransferase BG06_519 ENOG4105KRN Transcriptional regulator, abrb family BG06_5191 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BG06_5193 ENOG4105MSB protein, conserved in bacteria BG06_5197 ENOG4108M1A Chitin-binding protein BG06_5198 ENOG41082BV acetyltransferase BG06_5204 ENOG4108IJ7 Glycine betaine BG06_5209 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BG06_5211 ENOG4105DBI uridine monophosphokinase BG06_5212 ENOG4105RHY Pfam:UPF0157 BG06_5213 ENOG4105E1F short-chain dehydrogenase reductase BG06_5215 ENOG4107RUY (E1 component), alpha subunit BG06_5217 ENOG4107QKR Dehydrogenase BG06_5221 ENOG4105E98 transcriptional regulator DeoR family BG06_5225 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BG06_5231 ENOG4107Z3H Transcriptional regulator, TetR family BG06_5238 ENOG4105MSI germination protein ypeb BG06_5250 ENOG4105FDR Membrane BG06_5252 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BG06_5257 ENOG4108IUM Glycogen debranching enzyme BG06_5261 ENOG4105U0R haloacid dehalogenase-like hydrolase BG06_5266 ENOG4107VFR oxidoreductase BG06_5274 ENOG4105PKS Excinuclease abc c subunit domain protein BG06_5281 ENOG4105KWG Pfam:DUF1696 BG06_5282 ENOG4108NRW Phospholipase, patatin family BG06_5287 ENOG4108XI2 Domain of unknown function (DUF1963) BG06_529 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BG06_5294 ENOG4108Z4K mutator MutT protein BG06_5295 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BG06_5296 ENOG4105E09 nadh pyrophosphatase BG06_5299 ENOG4105FCD Major Facilitator BG06_53 ENOG4107RF6 penicillin-binding protein BG06_5306 ENOG4107Y9U Membrane BG06_531 ENOG4105YWU small acid-soluble spore protein BG06_5310 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BG06_5314 ENOG4107Y80 Major Facilitator superfamily BG06_532 ENOG4108WBH protein TIM barrel BG06_5323 ENOG4105FQP Beta-lactamase BG06_5325 ENOG4105CJN penicillin-binding protein BG06_5326 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BG06_5327 ENOG4105CB2 alcohol dehydrogenase BG06_5328 ENOG4105RHY Pfam:UPF0157 BG06_5330 ENOG4108HGU Histidine kinase BG06_5337 ENOG4107RF6 penicillin-binding protein BG06_5338 ENOG4105BZU Histidine kinase BG06_5339 ENOG410667J hydrolase BG06_535 ENOG4105CEY Amp-dependent synthetase and ligase BG06_5357 ENOG4108TFU terminase (Small subunit) BG06_5358 ENOG4105CNU cell division protein FtsK BG06_536 ENOG4105DUU IucA IucC family protein BG06_5370 ENOG4105ETU transcriptional activator (TenA BG06_5373 ENOG4105D6E homoserine dehydrogenase BG06_538 ENOG4105VRR gCN5-related N-acetyltransferase BG06_5386 ENOG4105DK7 lysyl-tRNA synthetase BG06_5388 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BG06_539 ENOG4105KT7 mgtC SapB transporter BG06_5390 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BG06_54 ENOG4107RF6 penicillin-binding protein BG06_5401 ENOG4105CUV Homoserine Kinase BG06_5405 ENOG4107Y80 Major Facilitator superfamily BG06_5407 ENOG4105FQP Beta-lactamase BG06_541 ENOG4107VMI polysaccharide deacetylase BG06_5416 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BG06_542 ENOG4105BZU Histidine kinase BG06_543 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG06_5431 ENOG4105K4H Nlp p60 protein BG06_5446 ENOG4105C9U ATP-dependent DNA helicase RecQ BG06_545 ENOG4108KGH TRANSCRIPTIONal BG06_5454 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG06_5459 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BG06_5464 ENOG4105DVF Cytosine-specific methyltransferase BG06_5466 ENOG4108J59 Extracellular solute-binding protein, family 5 BG06_5475 ENOG4107QJE Chromosome Partitioning Protein BG06_5481 ENOG4105EWC Purine nucleoside phosphorylase BG06_550 ENOG4105D6E homoserine dehydrogenase BG06_553 ENOG4106AKJ BG06_554 ENOG4108ZJ4 polysaccharide deacetylase BG06_555 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BG06_558 ENOG4105BZU Histidine kinase BG06_559 ENOG4105EFI regulatoR BG06_560 ENOG4105BZ1 (ABC) transporter BG06_565 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BG06_568 ENOG4108JJ8 (ABC) transporter BG06_569 ENOG4108JJ9 ABC, transporter BG06_570 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BG06_571 ENOG4105C4M (Ubiquinol oxidase) subunit I BG06_577 ENOG4105SKE transcriptional Regulator LysR family BG06_579 ENOG4105C32 Amino acid ABC transporter (Permease) BG06_580 ENOG4108IV0 ABC, transporter BG06_581 ENOG4105C0Z ABC transporter BG06_583 ENOG4105CKI cobalamin synthesis protein BG06_585 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BG06_586 ENOG4106F5Q Membrane BG06_587 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BG06_589 ENOG4108TVJ Nitroreductase BG06_59 ENOG4105CIN aminoacyl-histidine dipeptidase BG06_590 ENOG4107ZXU DSBA oxidoreductase BG06_591 ENOG4108Z40 Transcriptional regulator BG06_592 ENOG4105GZI Transcriptional regulator BG06_593 ENOG4107RT3 EamA-like transporter family BG06_595 ENOG4105KTB nuclear export factor GLE1 BG06_596 ENOG4108T5E Copper resistance protein BG06_608 ENOG4107R16 Multicopper oxidase BG06_609 ENOG4107RAQ aminopeptidase BG06_614 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BG06_615 ENOG4105D9N nucleoside BG06_617 ENOG4107RHR regulatoR BG06_624 ENOG4105C0X amino acid BG06_630 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BG06_634 ENOG41068WN BG06_64 ENOG41090HR transcriptional regulator BG06_640 ENOG4105F6J Alpha beta hydrolase fold BG06_644 ENOG4105CYC Transferase BG06_645 ENOG4105DY9 regulatoR BG06_646 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BG06_648 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BG06_649 ENOG4105C6X Major Facilitator BG06_65 ENOG4107RA9 decarboxylase BG06_654 ENOG4105C7B Threonine dehydratase BG06_657 ENOG4108ZP8 Acetolactate synthase small subunit BG06_658 ENOG4105C7K acetolactate synthase BG06_659 ENOG4105CM2 brancheD-chain amino acid aminotransferase BG06_66 ENOG4108I0C methyltransferase BG06_660 ENOG4105CHR reductase BG06_661 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BG06_664 ENOG4105H67 Protein of unknown function (DUF421) BG06_665 ENOG4105X5K response regulator receiver protein BG06_667 ENOG4105C8J )-transporter BG06_671 ENOG4105C6T cysteine synthase BG06_672 ENOG4105EU0 Major facilitator Superfamily BG06_673 ENOG4108J59 Extracellular solute-binding protein, family 5 BG06_674 ENOG4105DIB Oligopeptide-binding protein BG06_675 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BG06_678 ENOG4105DXI Major Facilitator superfamily BG06_68 ENOG41088CC tellurite resistance protein tehB BG06_680 ENOG4105U3E Transcriptional regulator BG06_681 ENOG4105CSR polyphosphate kinase 2 BG06_688 ENOG4105FVX BG06_699 ENOG4105C6K Malic enzyme BG06_7 ENOG4105DBI uridine monophosphokinase BG06_700 ENOG4108IJ0 Aspartate ammonia-lyase BG06_702 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BG06_704 ENOG4108IBT Inherit from COG: transposase BG06_710 ENOG4105CJ1 ABC, transporter BG06_717 ENOG4106BRA Membrane BG06_72 ENOG4108RZE Tetr family transcriptional regulator BG06_723 ENOG4107QIV Cytochrome c biogenesis protein BG06_727 ENOG4105EC3 peptidase S51, dipeptidase E BG06_728 ENOG4107QJQ Mate efflux family protein BG06_730 ENOG4105C5X domain protein BG06_732 ENOG4105C9Q fumarate hydratase class II BG06_734 ENOG4105VUF Transcriptional regulator BG06_735 ENOG4105DFD Na H antiporter BG06_738 ENOG4108PJD permease BG06_739 ENOG4105CKI cobalamin synthesis protein BG06_740 ENOG4108UZ3 Transporter BG06_741 ENOG4105DRR Transcriptional regulator, GntR family BG06_743 ENOG4105PGM cation diffusion facilitator family transporter BG06_75 ENOG4105C1J atp-dependent rna helicase BG06_750 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BG06_759 ENOG4105DQ6 Transposase BG06_761 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BG06_766 ENOG4105CAQ asparagine synthetase BG06_768 ENOG4105K56 Transcriptional regulator BG06_77 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BG06_772 ENOG4105CVJ phosphoglycerate mutase BG06_779 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BG06_780 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BG06_781 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BG06_782 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BG06_783 ENOG4105DUM transcriptional regulator, lysR family BG06_788 ENOG4105KAC Antibiotic biosynthesis monooxygenase BG06_795 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BG06_796 ENOG4105KTQ flagellar basal-body rod protein BG06_797 ENOG4105FZW flagellar biosynthesis regulator FlhF BG06_798 ENOG4105D7B Flagellar biosynthesis protein flha BG06_799 ENOG4105D00 flagellar biosynthetic protein flhB BG06_8 ENOG4105WCN acetyltransferase BG06_801 ENOG4105VS8 Flagellar biosynthetic protein fliq BG06_802 ENOG4105CN7 Flagellar biosynthetic protein FliP BG06_804 ENOG4105DD5 Flagellar motor switch protein BG06_805 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BG06_807 ENOG4105E4C Lytic transglycosylase catalytic BG06_808 ENOG4105I03 Flagellin BG06_809 ENOG4105I03 Flagellin BG06_811 ENOG4107R88 Chemotaxis protein (CheV) BG06_814 ENOG4105BZE flagellar hook protein, FlgE BG06_82 ENOG4107STF Involved in phosphonate degradation (By similarity) BG06_820 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BG06_821 ENOG4107U2N Flagellar M-ring protein BG06_822 ENOG41075Z6 flagellar hook-basal body complex protein fliE BG06_823 ENOG4108ZC9 flagellar basal-body rod protein flgc BG06_824 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BG06_827 ENOG4107TPX flagellar hook-associated BG06_828 ENOG4105DTJ flagellar hook-associated protein BG06_829 ENOG4105E1Q flagellar hook-associated protein BG06_833 ENOG4105BZU Histidine kinase BG06_836 ENOG4105DD5 Flagellar motor switch protein BG06_837 ENOG4105CBS Chea signal transduction histidine kinase BG06_838 ENOG4107YTP response regulator receiver protein BG06_839 ENOG4105ER2 Ompa motb domain protein BG06_84 ENOG4105RD7 BadF BadG BcrA BcrD BG06_840 ENOG4107R0U MotA TolQ exbB proton channel BG06_844 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BG06_857 ENOG41080C8 DUF218 domain BG06_858 ENOG4105H67 Protein of unknown function (DUF421) BG06_860 ENOG4108Z5V transcriptional regulator, merr family BG06_861 ENOG4105CN5 Metallo-Beta-Lactamase BG06_862 ENOG4107RWR Sodium hydrogen exchanger BG06_864 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG06_877 ENOG41081VK Ribonuclease BG06_881 ENOG4108SZE gCN5-related N-acetyltransferase BG06_884 ENOG4105CPK Glycosyl transferase (Group 1 BG06_89 ENOG4105F32 YngK protein BG06_896 ENOG4106032 Glutathionylspermidine synthase BG06_900 ENOG4105KHC sulfurtransferase BG06_902 ENOG4108W0I acetyltransferase BG06_904 ENOG410890F Dynamin family BG06_906 ENOG4105DHF Membrane BG06_907 ENOG4105C2W permease BG06_909 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BG06_912 ENOG4105CTD carboxy-peptidase BG06_913 ENOG4105DVT helicase BG06_915 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BG06_926 ENOG4105BZ4 penicillin-binding protein BG06_928 ENOG4105CSM endonuclease III BG06_932 ENOG4105YAC BG06_933 ENOG4105DVT helicase BG06_94 ENOG4108KPJ rna polymerase sigma factor BG06_940 ENOG4105CPK Glycosyl transferase (Group 1 BG06_941 ENOG4105FJR Lmbe family BG06_944 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BG06_945 ENOG4108JYZ YitT family BG06_951 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BG06_952 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BG06_953 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BG06_956 ENOG41068YB TPR repeat-containing protein BG06_961 ENOG4105EAH synthase BG06_963 ENOG4105XXQ heptaprenyl diphosphate synthase component I BG06_966 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BG06_972 ENOG41065D1 BG06_973 ENOG4105S2F BG06_980 ENOG4107RB3 L-asparaginase BG06_981 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BG06_986 ENOG4108S6Z Negative regulator of genetic competence BG06_987 ENOG4107X2D transcriptional regulator, merr family BG06_988 ENOG4107RGJ metallophosphoesterase BG06_990 ENOG4105I7S Abortive infection protein BG06_991 ENOG4105C9U ATP-dependent DNA helicase RecQ BG06_994 ENOG4108SAX Membrane BG06_996 ENOG41063SB peptidase BG06_997 ENOG4108WBT adenosyltransferase BG06_998 ENOG4105BZU Histidine kinase BG06_999 ENOG4105CK6 Two component transcriptional regulator (Winged helix family