locus-tag class description CAB88_00070 ENOG4105C8B TIGR00159 family CAB88_00075 ENOG4107U5W ybbr family CAB88_00090 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CAB88_00115 ENOG4108PSK reductase CAB88_00120 ENOG4108UMI ABC transporter, permease CAB88_00125 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CAB88_00130 ENOG4105D01 (LipO)protein CAB88_00135 ENOG4105CB2 alcohol dehydrogenase CAB88_00145 ENOG4105IQ5 FAD linked oxidase domain protein CAB88_00160 ENOG4105C2C drug resistance transporter, Bcr CflA CAB88_00180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CAB88_00190 ENOG4105C3U ABC transporter CAB88_00195 ENOG4108JQ7 (ABC) transporter CAB88_00215 ENOG4108J59 Extracellular solute-binding protein, family 5 CAB88_00220 ENOG4108J59 Extracellular solute-binding protein, family 5 CAB88_00240 ENOG4106Z1T Nicotinamide Mononucleotide Transporter CAB88_00250 ENOG4105E0C molybdate abc transporter CAB88_00255 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CAB88_00260 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CAB88_00275 ENOG4105EGI Transcriptional regulator CAB88_00295 ENOG4105F6E Acyl-transferase CAB88_00320 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CAB88_00340 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CAB88_00365 ENOG4105C5H ABC transporter CAB88_00380 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CAB88_00390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CAB88_00395 ENOG4105C3U ABC transporter CAB88_00400 ENOG4108JQ7 (ABC) transporter CAB88_00405 ENOG410667J hydrolase CAB88_00435 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CAB88_00440 ENOG4105ERH Fumarylacetoacetate hydrolase CAB88_00450 ENOG4105CUB amino acid CAB88_00460 ENOG4108SC4 )-transporter CAB88_00465 ENOG4105CPF Cell wall formation (By similarity) CAB88_00470 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CAB88_00495 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CAB88_00500 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CAB88_00510 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CAB88_00615 ENOG4105K8N protein family UPF0079, ATPase CAB88_00620 ENOG41072GX Peptidase M22 Glycoprotease CAB88_00625 ENOG410801F ribosomal-protein-alanine acetyltransferase CAB88_00630 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CAB88_00635 ENOG4105C5H ABC transporter CAB88_00650 ENOG4108TYN CAAX amino terminal protease family protein CAB88_00680 ENOG4105C7N Xanthine uracil vitamin C permease CAB88_00690 ENOG4105BZU Histidine kinase CAB88_00715 ENOG4107ZXU DSBA oxidoreductase CAB88_00770 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CAB88_00800 ENOG4105SX7 Transporter CAB88_00830 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CAB88_00835 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CAB88_00840 ENOG4105C83 adenylosuccinate lyase CAB88_00850 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CAB88_00875 ENOG4108V3E phosphoribosylglycinamide formyltransferase CAB88_00885 ENOG4105C12 Phosphoribosylglycinamide synthetase CAB88_00895 ENOG4105EGI Transcriptional regulator CAB88_00920 ENOG4105C4R Atp-dependent dna helicase CAB88_00925 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CAB88_00945 ENOG4108W2Y isochorismatase CAB88_00950 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CAB88_00955 ENOG4108UMI ABC transporter, permease CAB88_00960 ENOG4105D01 (LipO)protein CAB88_00980 ENOG410834F Transcriptional regulator CAB88_00985 ENOG4107I77 yiaA/B two helix domain CAB88_01005 ENOG4105CBD Diacylglycerol kinase CAB88_01015 ENOG4108JPW Aminotransferase CAB88_01025 ENOG4105C26 Dehydrogenase CAB88_01030 ENOG4105KPY Small multidrug resistance protein CAB88_01055 ENOG4105D9N nucleoside CAB88_01060 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CAB88_01070 ENOG4108W15 Protein of unknown function (DUF1456) CAB88_01085 ENOG4105DTQ mandelate racemase muconate lactonizing CAB88_01095 ENOG4105DFD Na H antiporter CAB88_01120 ENOG4105D3R alkyl hydroperoxide reductase CAB88_01125 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CAB88_01130 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CAB88_01135 ENOG4107W7X Aldolase CAB88_01140 ENOG4105EHG Permease protein CAB88_01145 ENOG4105DQ5 transport system permease protein CAB88_01150 ENOG4108V5C ABC transporter CAB88_01160 ENOG4105CAY ferredoxin--nadp reductase CAB88_01180 ENOG4106UIA CAB88_01185 ENOG4106UIA CAB88_01205 ENOG4105BZU Histidine kinase CAB88_01225 ENOG410756H nucleotidyltransferase CAB88_01230 ENOG4105D2S major facilitator superfamily CAB88_01245 ENOG4105E5Q amino acid AbC transporter CAB88_01250 ENOG4105EAB amino acid AbC transporter CAB88_01260 ENOG4105C8Q Methyl-accepting chemotaxis CAB88_01275 ENOG4105DBV ornithine carbamoyltransferase CAB88_01285 ENOG4105C5B carbamate kinase CAB88_01290 ENOG4108W63 CRP FNR family transcriptional regulator CAB88_01300 ENOG4105DNP FAD linked oxidase domain protein CAB88_01310 ENOG4105CI1 PTS System CAB88_01325 ENOG4105C9U ATP-dependent DNA helicase RecQ CAB88_01340 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CAB88_01360 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CAB88_01365 ENOG4105D2X ABC transporter substrate-binding protein CAB88_01375 ENOG4105C5H ABC transporter CAB88_01410 ENOG41062JF Transcriptional regulator CAB88_01425 ENOG4105DEU major facilitator superfamily CAB88_01440 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CAB88_01455 ENOG4108N0M stress protein CAB88_01460 ENOG4106FN3 tellurium resistance protein CAB88_01465 ENOG4106FN3 tellurium resistance protein CAB88_01470 ENOG4107TS3 membrane protein, TerC CAB88_01475 ENOG4108TTB tellurium resistance protein CAB88_01490 ENOG41068PA UPF0435 protein CAB88_01495 ENOG4105KJF protein tyrosine phosphatase CAB88_01505 ENOG4107U9T Pfam:Ribonuclease_BN CAB88_01515 ENOG4105C59 p-type ATPase CAB88_01520 ENOG4108IPJ Membrane CAB88_01540 ENOG4107ZTW SNARE associated Golgi CAB88_01555 ENOG410606W general stress protein CAB88_01560 ENOG4105UPD Calcium Proton CAB88_01595 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CAB88_01600 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CAB88_01610 ENOG4108JUB Transcriptional regulator CAB88_01620 ENOG4108IQI permease CAB88_01660 ENOG4108A04 Beta-lactamase CAB88_01675 ENOG4107R51 Glycosyl transferase, family 2 CAB88_01680 ENOG4107QQG Dehydrogenase CAB88_01685 ENOG4105C3I Nad-dependent epimerase dehydratase CAB88_01690 ENOG4105CKK Glycosyl transferase, family 2 CAB88_01705 ENOG4105F1A Pyruvate formate-lyase CAB88_01725 ENOG4105CI2 imidazolone-5-propionate hydrolase CAB88_01730 ENOG4105ECP epimerase CAB88_01760 ENOG41067AE Membrane-bound metal-dependent hydrolase CAB88_01765 ENOG4105CEN a g-specific adenine glycosylase CAB88_01770 ENOG4106BXE CAB88_01790 ENOG4105BZ1 (ABC) transporter CAB88_01795 ENOG4107NBY Membrane CAB88_01800 ENOG4105CBC glutamate synthase CAB88_01810 ENOG4108IUW ABC transporter CAB88_01830 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CAB88_01835 ENOG4105G5W regulator Fur family CAB88_01960 ENOG4108JQC penicillin-binding protein 1A CAB88_01965 ENOG4108R9S DSBA oxidoreductase CAB88_01975 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CAB88_01985 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CAB88_01990 ENOG4105BZU Histidine kinase CAB88_02000 ENOG4105CYN Serine protein kinase CAB88_02025 ENOG4105C94 Transporter CAB88_02040 ENOG4105DZ6 Band 7 protein CAB88_02050 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CAB88_02055 ENOG4108V9W transcriptional regulatory protein CAB88_02060 ENOG4105D4T Citrate transporter CAB88_02085 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CAB88_02090 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CAB88_02095 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CAB88_02100 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CAB88_02105 ENOG4105BZ7 extracellular solute-binding protein family 1 CAB88_02110 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CAB88_02115 ENOG4108STX response regulator CAB88_02120 ENOG4105US7 Histidine kinase CAB88_02145 ENOG4108MRH transcriptional regulatory protein CAB88_02155 ENOG4105C6K Malic enzyme CAB88_02165 ENOG4108UZ3 Transporter CAB88_02170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CAB88_02180 ENOG4105BZU Histidine kinase CAB88_02185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_02195 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CAB88_02200 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CAB88_02205 ENOG4108JB9 formate dehydrogenase CAB88_02225 ENOG4105CUB amino acid CAB88_02235 ENOG4105C59 p-type ATPase CAB88_02240 ENOG4105DAP Nicotinate phosphoribosyltransferase CAB88_02275 ENOG41073R8 VanW family CAB88_02280 ENOG4108KGH TRANSCRIPTIONal CAB88_02285 ENOG4105D9N nucleoside CAB88_02290 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CAB88_02295 ENOG41085W3 Transposase CAB88_02300 ENOG4105C37 (CBS) domain CAB88_02305 ENOG4108IJ0 Aspartate ammonia-lyase CAB88_02310 ENOG4105DAA L-lactate CAB88_02330 ENOG4105DUX Transporter CAB88_02335 ENOG4108MES Periplasmic binding protein CAB88_02340 ENOG4105DQ5 transport system permease protein CAB88_02345 ENOG4108IHU transport system permease protein CAB88_02350 ENOG4105E0A ABC, transporter CAB88_02365 ENOG4105EKQ RNA-directed DNA polymerase CAB88_02375 ENOG4105EXW epimerase dehydratase CAB88_02385 ENOG4107T89 von Willebrand factor, type A CAB88_02390 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CAB88_02395 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CAB88_02410 ENOG4105BZU Histidine kinase CAB88_02415 ENOG4105D5Q Arginine ornithine antiporter CAB88_02420 ENOG4107414 GntR family transcriptional regulator CAB88_02425 ENOG4105C5Y PTS System CAB88_02430 ENOG4105CG3 alpha amylase, catalytic region CAB88_02450 ENOG4105E1K spore germination protein CAB88_02460 ENOG4105CRN Aminoglycoside phosphotransferase CAB88_02465 ENOG4105BZG amino acid carrier protein CAB88_02470 ENOG4105CDA abc transporter atp-binding protein CAB88_02475 ENOG4105CT1 (ABC) transporter CAB88_02480 ENOG4105EAD ABC transporter CAB88_02485 ENOG4105DRP amino acid AbC transporter CAB88_02490 ENOG4108IQI permease CAB88_02505 ENOG4105GFR rna polymerase sigma factor CAB88_02515 ENOG4105D29 Helix-turn-helix type 11 domain protein CAB88_02520 ENOG4105NAE bifunctional deaminase-reductase domain protein CAB88_02525 ENOG4105BZU Histidine kinase CAB88_02550 ENOG4105CHH sulfate transporter CAB88_02555 ENOG41068KF Universal stress protein CAB88_02565 ENOG4105DEF Extracellular solute-binding protein, family 5 CAB88_02575 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CAB88_02580 ENOG4108JQ7 (ABC) transporter CAB88_02590 ENOG4105CXY transporter CAB88_02595 ENOG41067TZ transcriptional regulator, MarR family CAB88_02600 ENOG4105C0R drug resistance transporter emrb qaca subfamily CAB88_02605 ENOG4105ETE Transcriptional regulator (LacI family CAB88_02610 ENOG4108RVA ribokinase CAB88_02620 ENOG4105C2J ABC transporter CAB88_02625 ENOG4105CNN ABC, transporter CAB88_02630 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CAB88_02635 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CAB88_02670 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) CAB88_02685 ENOG4108IMY Transcriptional regulator CAB88_02725 ENOG4108NF7 phage-type endonuclease CAB88_02730 ENOG4108PNI recT protein CAB88_02775 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAB88_02785 ENOG4105WXW Antirepressor CAB88_02810 ENOG4108C33 Resolvase CAB88_02905 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CAB88_02925 ENOG4105CNU cell division protein FtsK CAB88_02965 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CAB88_02970 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CAB88_02975 ENOG41069ER domain protein CAB88_02980 ENOG4105VZ8 Transcriptional regulator CAB88_02985 ENOG4107D63 CAB88_03000 ENOG4105DUX Transporter CAB88_03020 ENOG4105C85 amino acid CAB88_03025 ENOG4105C7N Xanthine uracil vitamin C permease CAB88_03040 ENOG4105MA6 gCN5-related N-acetyltransferase CAB88_03060 ENOG4105CCU oxidase (Subunit III) CAB88_03065 ENOG4105BZ9 Cytochrome C oxidase, subunit I CAB88_03070 ENOG4105E2S oxidase) subunit II CAB88_03090 ENOG4106CAD Protein of unknown function (DUF3311) CAB88_03095 ENOG4105E1V na solute symporter CAB88_03110 ENOG4108NHD germination protein CAB88_03125 ENOG4108NHD germination protein CAB88_03135 ENOG4105CE1 Ferrous iron transport protein b CAB88_03140 ENOG4105CE1 Ferrous iron transport protein b CAB88_03145 ENOG4105CE1 Ferrous iron transport protein b CAB88_03150 ENOG4105CVA phosphate CAB88_03155 ENOG4105C8U phosphate abc transporter CAB88_03160 ENOG4105E2Z phosphate ABC transporter (Permease CAB88_03295 ENOG41080XQ Signal transduction protein with cbs domains CAB88_03320 ENOG4105ETU transcriptional activator (TenA CAB88_03330 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CAB88_03340 ENOG4108VEU Thiamine monophosphate synthase CAB88_03345 ENOG41080HI glycine oxidase CAB88_03360 ENOG4105D06 uba thif-type nad fad binding protein CAB88_03365 ENOG4105DWF phosphomethylpyrimidine kinase CAB88_03400 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CAB88_03415 ENOG4108INS Transcriptional regulator CAB88_03430 ENOG4105C7N Xanthine uracil vitamin C permease CAB88_03440 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CAB88_03460 ENOG4105C5Y PTS System CAB88_03475 ENOG4105K63 Thioredoxin CAB88_03495 ENOG4108B31 Spore germination protein CAB88_03515 ENOG4107Y03 Nitroreductase CAB88_03520 ENOG4105ED1 spovr family CAB88_03530 ENOG4105J4Q Transcriptional regulator CAB88_03550 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CAB88_03555 ENOG4105XTG Pfam:DUF156 CAB88_03560 ENOG4105VFE sira family CAB88_03565 ENOG4107TPS domain protein CAB88_03570 ENOG4105VFE sira family CAB88_03575 ENOG41085GJ domain protein CAB88_03585 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CAB88_03590 ENOG41087NI Sulfite exporter TauE/SafE CAB88_03600 ENOG4108KGH TRANSCRIPTIONal CAB88_03630 ENOG4105EMD TRANSCRIPTIONal CAB88_03635 ENOG4105VCP PTS System CAB88_03640 ENOG4105VZJ PTS System CAB88_03660 ENOG41069ER domain protein CAB88_03665 ENOG4107RBB ABC transporter, permease CAB88_03670 ENOG4105C19 ABC transporter CAB88_03700 ENOG4105WEF catalase CAB88_03735 ENOG4107T5V SNARE associated Golgi CAB88_03770 ENOG4105CUB amino acid CAB88_03775 ENOG4107RWR Sodium hydrogen exchanger CAB88_03785 ENOG4106KNT transcriptional regulator CAB88_03825 ENOG4108YXU transcriptional regulator AsnC family CAB88_03830 ENOG4105CH7 arginosuccinase CAB88_03835 ENOG4105UBK short-chain dehydrogenase reductase CAB88_03845 ENOG4105KPY Small multidrug resistance protein CAB88_03880 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CAB88_03885 ENOG4105E5W Transporter CAB88_03895 ENOG4107RKG DJ-1/PfpI family CAB88_03900 ENOG4105CH6 catalase CAB88_03910 ENOG4105D5Q Arginine ornithine antiporter CAB88_03915 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CAB88_03925 ENOG4105C26 Dehydrogenase CAB88_03945 ENOG4105BZ1 (ABC) transporter CAB88_03950 ENOG4105BZ1 (ABC) transporter CAB88_03965 ENOG4105DRP amino acid AbC transporter CAB88_03970 ENOG4105CDA abc transporter atp-binding protein CAB88_03985 ENOG410839P CAB88_03995 ENOG4108UH6 UPF0754 membrane protein CAB88_04025 ENOG4107FQX Alpha-acetolactate decarboxylase CAB88_04050 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CAB88_04055 ENOG4105D4P Coproporphyrinogen iii oxidase CAB88_04060 ENOG4105CEY Amp-dependent synthetase and ligase CAB88_04075 ENOG4105CHH sulfate transporter CAB88_04105 ENOG4105CGU Enoyl-CoA hydratase CAB88_04125 ENOG4105DER m42 family CAB88_04145 ENOG4105CTU Proline racemase CAB88_04150 ENOG4105CIF Ornithine Cyclodeaminase CAB88_04170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CAB88_04175 ENOG4105C3U ABC transporter CAB88_04180 ENOG4108JQ7 (ABC) transporter CAB88_04235 ENOG4105CSH Transporter CAB88_04245 ENOG4108MRH transcriptional regulatory protein CAB88_04255 ENOG4105M6F mutator MutT protein CAB88_04270 ENOG4105CDU Replicative dna helicase CAB88_04310 ENOG4105C0R drug resistance transporter emrb qaca subfamily CAB88_04345 ENOG4105F6J Alpha beta hydrolase fold CAB88_04400 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CAB88_04415 ENOG4105F27 Major Facilitator CAB88_04420 ENOG4105WAB arsR family transcriptional regulator CAB88_04435 ENOG4105CMT Dihydroxyacetone kinase CAB88_04445 ENOG4105CMT Dihydroxyacetone kinase CAB88_04540 ENOG4108WC5 Alpha Beta Hydrolase Fold protein CAB88_04590 ENOG4105WN5 stage II sporulation protein CAB88_04600 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAB88_04610 ENOG4108MJI response regulator CAB88_04615 ENOG4105BZU Histidine kinase CAB88_04620 ENOG4105BZU Histidine kinase CAB88_04660 ENOG4105EKQ RNA-directed DNA polymerase CAB88_04670 ENOG4107QHE Choloylglycine hydrolase CAB88_04690 ENOG4107VRP DNA repair exonuclease CAB88_04695 ENOG4106D4I domain protein CAB88_04715 ENOG410829K Lysine exporter protein (Lyse ygga) CAB88_04745 ENOG4108MUZ hydrolase CAB88_04770 ENOG4105F0F Oxalate decarboxylase CAB88_04775 ENOG41067QW Transcriptional regulator CAB88_04780 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CAB88_04795 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CAB88_04815 ENOG4105EMN RNA polymerase sigma factor CAB88_04830 ENOG4105EEM helicase CAB88_04840 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CAB88_04870 ENOG4105K59 histidine triad (HIT) protein CAB88_04940 ENOG410905X membrane-flanked domain protein CAB88_04945 ENOG4105CKV Membrane CAB88_04995 ENOG410905X membrane-flanked domain protein CAB88_05000 ENOG4105CKV Membrane CAB88_05005 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CAB88_05010 ENOG4105BZ4 penicillin-binding protein CAB88_05020 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CAB88_05025 ENOG4105C1Q protoporphyrinogen oxidase CAB88_05050 ENOG4105NA0 Transcriptional regulator CAB88_05065 ENOG4105ECB domain protein CAB88_05085 ENOG4108MK9 spermidine N(1)-acetyltransferase CAB88_05095 ENOG4106AXD CAB88_05100 ENOG4108RQ5 Beta-lactamase domain-containing protein CAB88_05105 ENOG4105DF9 Lipoate-protein, ligase CAB88_05115 ENOG4105CEY Amp-dependent synthetase and ligase CAB88_05125 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CAB88_05130 ENOG4108I5D sulfate abc transporter CAB88_05135 ENOG4105ECW sulfate abc transporter CAB88_05140 ENOG4108IJ6 ABC transporter CAB88_05145 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) CAB88_05155 ENOG4107RN3 metallophosphoesterase CAB88_05160 ENOG4107TVP HD domain protein CAB88_05170 ENOG4108AEY RNA polymerase sigma factor CAB88_05175 ENOG41086D8 Transcriptional regulator CAB88_05180 ENOG41085W3 Transposase CAB88_05195 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CAB88_05215 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CAB88_05220 ENOG4105C8Q Methyl-accepting chemotaxis CAB88_05230 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) CAB88_05240 ENOG4107QP3 malate synthase g CAB88_05260 ENOG4105VEQ Cold shock protein CAB88_05295 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CAB88_05300 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CAB88_05340 ENOG4105ERH Fumarylacetoacetate hydrolase CAB88_05350 ENOG4105C8Y Acetylornithine aminotransferase CAB88_05365 ENOG4105CAQ asparagine synthetase CAB88_05370 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CAB88_05375 ENOG4105CH6 catalase CAB88_05380 ENOG4105BZU Histidine kinase CAB88_05410 ENOG4105QNR S1 RNA binding domain protein CAB88_05415 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CAB88_05425 ENOG4107AYK membrAne CAB88_05430 ENOG41073B9 CAB88_05440 ENOG4108KP7 hydrolase CAB88_05455 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CAB88_05480 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CAB88_05485 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CAB88_05500 ENOG4105C31 Tryptophanyl-tRNA synthetase CAB88_05520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CAB88_05525 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CAB88_05535 ENOG4108JQ7 (ABC) transporter CAB88_05540 ENOG4105UQX Mate efflux family protein CAB88_05570 ENOG4108ZCF integral membrane protein CAB88_05580 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CAB88_05600 ENOG4105DPN Oligoendopeptidase f CAB88_05615 ENOG4108Z18 K06886 hemoglobin CAB88_05620 ENOG4105MIX Adenylate cyclase CAB88_05625 ENOG4106EFP UPF0738 protein CAB88_05635 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CAB88_05640 ENOG4105EMS pseudouridine synthase CAB88_05660 ENOG4105K64 Glycosyl transferase, family 2 CAB88_05680 ENOG4107TVC Glycosyl transferase, family 2 CAB88_05700 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CAB88_05705 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CAB88_05715 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CAB88_05790 ENOG4105CK7 Sodium proline symporter CAB88_05800 ENOG4105CRQ synthase (Component I) CAB88_05805 ENOG4105DDQ anthranilate synthase CAB88_05815 ENOG4105DK0 Indole-3-glycerol phosphate synthase CAB88_05820 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CAB88_05825 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CAB88_05860 ENOG4105T65 Membrane-associated protein CAB88_05890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CAB88_05910 ENOG4105C7S Dehydrogenase CAB88_05920 ENOG4105VZ8 Transcriptional regulator CAB88_05995 ENOG4105DZ1 carboxypeptidase CAB88_06000 ENOG4105VFR signal peptidase CAB88_06035 ENOG4105C26 Dehydrogenase CAB88_06040 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CAB88_06045 ENOG4105F38 ABC transporter, permease CAB88_06050 ENOG4105D38 putrescine abc transporter CAB88_06055 ENOG4107RUE extracellular solute-binding protein family 1 CAB88_06065 ENOG4105EYF MMPL domain protein CAB88_06075 ENOG4108YBP pseudouridine synthase CAB88_06085 ENOG4105K4I Scp-like extracellular CAB88_06090 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CAB88_06095 ENOG4105CQB FAD linked oxidase domain protein CAB88_06110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_06115 ENOG4105BZU Histidine kinase CAB88_06120 ENOG4105JXH GntR family transcriptional regulator CAB88_06140 ENOG4106A3R peptidase CAB88_06150 ENOG4108QTI )-transporter CAB88_06155 ENOG4107TS3 membrane protein, TerC CAB88_06160 ENOG4105CZN Potassium uptake protein CAB88_06165 ENOG410681C small acid-soluble spore protein CAB88_06170 ENOG4108Z7G MaoC domain protein dehydratase CAB88_06190 ENOG4105CHR reductase CAB88_06225 ENOG4105C4Y ABC transporter CAB88_06230 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CAB88_06235 ENOG4107RCV ABC transporter, permease CAB88_06255 ENOG4105E98 transcriptional regulator DeoR family CAB88_06270 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CAB88_06280 ENOG4105PXI polysaccharide deacetylase CAB88_06290 ENOG4105BZU Histidine kinase CAB88_06295 ENOG41090MY MarR family Transcriptional regulator CAB88_06305 ENOG4106DF1 CAB88_06315 ENOG4105BZU Histidine kinase CAB88_06320 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CAB88_06325 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CAB88_06330 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CAB88_06380 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CAB88_06385 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CAB88_06390 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CAB88_06395 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CAB88_06400 ENOG4105CZV ABC transporter CAB88_06410 ENOG4105CJ1 ABC, transporter CAB88_06450 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CAB88_06455 ENOG4105EA8 2-Nitropropane dioxygenase CAB88_06460 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CAB88_06470 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CAB88_06495 ENOG4105NQC Flavodoxin CAB88_06540 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CAB88_06570 ENOG4105CZN Potassium uptake protein CAB88_06575 ENOG41063Y9 CAB88_06580 ENOG4105KBJ sporulation protein ytfj CAB88_06610 ENOG4105CM2 brancheD-chain amino acid aminotransferase CAB88_06615 ENOG4105C7K acetolactate synthase CAB88_06620 ENOG4108ZP8 Acetolactate synthase small subunit CAB88_06625 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CAB88_06640 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CAB88_06660 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CAB88_06665 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CAB88_06670 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CAB88_06695 ENOG4107RVV histidinol phosphate phosphatase, hisj family CAB88_06710 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CAB88_06715 ENOG4105E0M Sulfatase CAB88_06725 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CAB88_06745 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CAB88_06750 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CAB88_06760 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CAB88_06765 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CAB88_06770 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CAB88_06780 ENOG4105C8J )-transporter CAB88_06800 ENOG4105DFD Na H antiporter CAB88_06820 ENOG4105ENE Histidine kinase CAB88_06825 ENOG4105WH1 Two component transcriptional regulator luxr family CAB88_06845 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CAB88_06870 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CAB88_06895 ENOG4105CJ3 phosphate transporter CAB88_06900 ENOG4107GRR phosphate transport regulator CAB88_06905 ENOG4105BZ4 penicillin-binding protein CAB88_06920 ENOG4105BZU Histidine kinase CAB88_06925 ENOG4105I3N Conserved Protein CAB88_06940 ENOG4105BZU Histidine kinase CAB88_06975 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CAB88_06980 ENOG4105DZ1 carboxypeptidase CAB88_06985 ENOG4108JIC nucleoside recognition domain protein CAB88_06995 ENOG4105FE9 pseudouridine synthase CAB88_07000 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CAB88_07005 ENOG4107TWT Cytochrome c biogenesis protein CAB88_07010 ENOG4105CRE cytochrome C CAB88_07015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_07020 ENOG4105BZU Histidine kinase CAB88_07025 ENOG4108WBT adenosyltransferase CAB88_07040 ENOG4108SAX Membrane CAB88_07055 ENOG4105C9U ATP-dependent DNA helicase RecQ CAB88_07060 ENOG4105I7S Abortive infection protein CAB88_07070 ENOG4107RGJ metallophosphoesterase CAB88_07075 ENOG4108XDN Transcriptional regulator CAB88_07080 ENOG4108S6Z Negative regulator of genetic competence CAB88_07105 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CAB88_07110 ENOG4107RB3 L-asparaginase CAB88_07145 ENOG4105S2F CAB88_07150 ENOG41065D1 CAB88_07180 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CAB88_07195 ENOG4105XXQ heptaprenyl diphosphate synthase component I CAB88_07205 ENOG4105EAH synthase CAB88_07210 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CAB88_07215 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CAB88_07230 ENOG41068YB TPR repeat-containing protein CAB88_07245 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CAB88_07250 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CAB88_07285 ENOG4108JYZ YitT family CAB88_07290 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CAB88_07305 ENOG4105FJR Lmbe family CAB88_07310 ENOG4105CPK Glycosyl transferase (Group 1 CAB88_07335 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CAB88_07350 ENOG4105DVT helicase CAB88_07355 ENOG4105YAC CAB88_07375 ENOG4105CSM endonuclease III CAB88_07385 ENOG4105BZ4 penicillin-binding protein CAB88_07430 ENOG4106F55 Protein of unknown function (DUF1273) CAB88_07445 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CAB88_07455 ENOG4105DVT helicase CAB88_07460 ENOG4105CTD carboxy-peptidase CAB88_07470 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CAB88_07475 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CAB88_07480 ENOG4105C2W permease CAB88_07485 ENOG4105DHF Membrane CAB88_07495 ENOG410890F Dynamin family CAB88_07505 ENOG4108W0I acetyltransferase CAB88_07515 ENOG4105KHC sulfurtransferase CAB88_07570 ENOG4105HTX biosynthesis protein CAB88_07600 ENOG4105CPK Glycosyl transferase (Group 1 CAB88_07615 ENOG4108SZE gCN5-related N-acetyltransferase CAB88_07635 ENOG41081VK Ribonuclease CAB88_07700 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CAB88_07710 ENOG4107RWR Sodium hydrogen exchanger CAB88_07715 ENOG4108Z5V transcriptional regulator, merr family CAB88_07725 ENOG4105H67 Protein of unknown function (DUF421) CAB88_07730 ENOG41080C8 DUF218 domain CAB88_07790 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CAB88_07800 ENOG4107R0U MotA TolQ exbB proton channel CAB88_07805 ENOG4105ER2 Ompa motb domain protein CAB88_07810 ENOG4107YTP response regulator receiver protein CAB88_07815 ENOG4105CBS Chea signal transduction histidine kinase CAB88_07820 ENOG4105DD5 Flagellar motor switch protein CAB88_07835 ENOG4105BZU Histidine kinase CAB88_07855 ENOG4105E1Q flagellar hook-associated protein CAB88_07860 ENOG4105DTJ flagellar hook-associated protein CAB88_07880 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CAB88_07885 ENOG4108ZC9 flagellar basal-body rod protein flgc CAB88_07890 ENOG41075Z6 flagellar hook-basal body complex protein fliE CAB88_07895 ENOG4107U2N Flagellar M-ring protein CAB88_07900 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CAB88_07930 ENOG4105BZE flagellar hook protein, FlgE CAB88_07945 ENOG4107R88 Chemotaxis protein (CheV) CAB88_07955 ENOG4105I03 Flagellin CAB88_07960 ENOG4105I03 Flagellin CAB88_07965 ENOG4105E4C Lytic transglycosylase catalytic CAB88_07975 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CAB88_07980 ENOG4105DD5 Flagellar motor switch protein CAB88_07990 ENOG4105CN7 Flagellar biosynthetic protein FliP CAB88_07995 ENOG4105VS8 Flagellar biosynthetic protein fliq CAB88_08005 ENOG4105D00 flagellar biosynthetic protein flhB CAB88_08010 ENOG4105D7B Flagellar biosynthesis protein flha CAB88_08015 ENOG4105FZW flagellar biosynthesis regulator FlhF CAB88_08020 ENOG4105KTQ flagellar basal-body rod protein CAB88_08025 ENOG4105CPU Monooxygenase CAB88_08030 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CAB88_08065 ENOG4105KAC Antibiotic biosynthesis monooxygenase CAB88_08070 ENOG4107QZ7 Cellulose synthase catalytic subunit CAB88_08095 ENOG4105DUM transcriptional regulator, lysR family CAB88_08100 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CAB88_08110 ENOG4105D38 putrescine abc transporter CAB88_08155 ENOG4105CVJ phosphoglycerate mutase CAB88_08165 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CAB88_08185 ENOG4105CAQ asparagine synthetase CAB88_08205 ENOG4105PGM cation diffusion facilitator family transporter CAB88_08215 ENOG4105DRR Transcriptional regulator, GntR family CAB88_08220 ENOG4108UZ3 Transporter CAB88_08230 ENOG4105CKI cobalamin synthesis protein CAB88_08240 ENOG4108PJD permease CAB88_08255 ENOG4105DFD Na H antiporter CAB88_08260 ENOG4105VUF Transcriptional regulator CAB88_08270 ENOG4105C9Q fumarate hydratase class II CAB88_08285 ENOG4107QJQ Mate efflux family protein CAB88_08290 ENOG4105EC3 peptidase S51, dipeptidase E CAB88_08310 ENOG4107QIV Cytochrome c biogenesis protein CAB88_08315 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CAB88_08325 ENOG4107JM4 Tetratricopeptide repeat CAB88_08340 ENOG4105BZC d-serine deaminase CAB88_08345 ENOG4106BRA Membrane CAB88_08385 ENOG4105CJ1 ABC, transporter CAB88_08405 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CAB88_08415 ENOG4108IJ0 Aspartate ammonia-lyase CAB88_08420 ENOG4105C6K Malic enzyme CAB88_08485 ENOG4105FVX CAB88_08500 ENOG4105CSR polyphosphate kinase 2 CAB88_08505 ENOG4105U3E Transcriptional regulator CAB88_08515 ENOG4105DXI Major Facilitator superfamily CAB88_08530 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CAB88_08535 ENOG4105EU0 Major facilitator Superfamily CAB88_08540 ENOG4105C6T cysteine synthase CAB88_08560 ENOG4105C8J )-transporter CAB88_08570 ENOG4105X5K response regulator receiver protein CAB88_08575 ENOG4105H67 Protein of unknown function (DUF421) CAB88_08605 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CAB88_08610 ENOG4105CHR reductase CAB88_08615 ENOG4105CM2 brancheD-chain amino acid aminotransferase CAB88_08620 ENOG4105C7K acetolactate synthase CAB88_08630 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CAB88_08640 ENOG4105C7B Threonine dehydratase CAB88_08665 ENOG4105C6X Major Facilitator CAB88_08670 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CAB88_08680 ENOG4105DY9 regulatoR CAB88_08685 ENOG4105CYC Transferase CAB88_08705 ENOG4105EQ0 Major Facilitator superfamily CAB88_08710 ENOG4108IND Tetr family transcriptional regulator CAB88_08720 ENOG41068WN CAB88_08745 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CAB88_08760 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CAB88_08765 ENOG4105C0X amino acid CAB88_08810 ENOG410849A acetyltransferase, (GNAT) family CAB88_08835 ENOG4107RHR regulatoR CAB88_08845 ENOG4105D9N nucleoside CAB88_08850 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CAB88_08880 ENOG410811B TRANSCRIPTIONal CAB88_08895 ENOG4107RAQ aminopeptidase CAB88_08905 ENOG4107R16 Multicopper oxidase CAB88_08950 ENOG4108T5E Copper resistance protein CAB88_08955 ENOG4105KTB nuclear export factor GLE1 CAB88_08960 ENOG4107RT3 EamA-like transporter family CAB88_08965 ENOG4105GZI Transcriptional regulator CAB88_08970 ENOG4108Z40 Transcriptional regulator CAB88_08975 ENOG4107ZXU DSBA oxidoreductase CAB88_08980 ENOG4108TVJ Nitroreductase CAB88_09025 ENOG41085W3 Transposase CAB88_09100 ENOG4105C2M dna polymerase I CAB88_09190 ENOG4105KRN Transcriptional regulator, abrb family CAB88_09335 ENOG4105XSJ toxin secretion phage lysis holin CAB88_09425 ENOG4106F5Q Membrane CAB88_09430 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CAB88_09445 ENOG4105CKI cobalamin synthesis protein CAB88_09455 ENOG4105C0Z ABC transporter CAB88_09460 ENOG4108IV0 ABC, transporter CAB88_09465 ENOG4105C32 Amino acid ABC transporter (Permease) CAB88_09475 ENOG4105EGI Transcriptional regulator CAB88_09485 ENOG4105MDS 4-oxalocrotonate tautomerase CAB88_09505 ENOG4105C4M (Ubiquinol oxidase) subunit I CAB88_09510 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CAB88_09515 ENOG4108JJ9 ABC, transporter CAB88_09520 ENOG4108JJ8 (ABC) transporter CAB88_09530 ENOG4105K64 Glycosyl transferase, family 2 CAB88_09540 ENOG4108UT6 Transferase hexapeptide repeat containing protein CAB88_09595 ENOG4105BZ1 (ABC) transporter CAB88_09600 ENOG4105EFI regulatoR CAB88_09605 ENOG4105BZU Histidine kinase CAB88_09625 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CAB88_09630 ENOG4108ZJ4 polysaccharide deacetylase CAB88_09650 ENOG4105D6E homoserine dehydrogenase CAB88_09660 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CAB88_09675 ENOG4108KGH TRANSCRIPTIONal CAB88_09685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CAB88_09690 ENOG4105BZU Histidine kinase CAB88_09695 ENOG4107VMI polysaccharide deacetylase CAB88_09705 ENOG4105KT7 mgtC SapB transporter CAB88_09710 ENOG4105VRR gCN5-related N-acetyltransferase CAB88_09720 ENOG4105DUU IucA IucC family protein CAB88_09725 ENOG4105CEY Amp-dependent synthetase and ligase CAB88_09740 ENOG4108WBH protein TIM barrel CAB88_09745 ENOG4105YWU small acid-soluble spore protein CAB88_09755 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CAB88_09760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CAB88_09810 ENOG4105KRN Transcriptional regulator, abrb family CAB88_09820 ENOG4105YVS arsR family transcriptional regulator CAB88_09825 ENOG4105CPC Aldo Keto reductase CAB88_09830 ENOG4107XZQ multidrug resistance protein CAB88_09855 ENOG4105C8Q Methyl-accepting chemotaxis CAB88_09875 ENOG4108K88 Membrane CAB88_09880 ENOG4108WPJ Ferritin-like domain CAB88_09895 ENOG4105DEN Luciferase family CAB88_09910 ENOG4105VMI -acetyltransferase CAB88_09915 ENOG4107QM2 Aldo Keto reductase CAB88_09920 ENOG4105CKI cobalamin synthesis protein CAB88_09930 ENOG4105DSE periplasmic solute binding protein CAB88_09940 ENOG4105K4T epimerase CAB88_09995 ENOG4107T5V SNARE associated Golgi CAB88_10010 ENOG4108PJD permease CAB88_10020 ENOG4108S4H thioesterase Superfamily protein CAB88_10030 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CAB88_10050 ENOG4105SXS Protein of unknown function (DUF456) CAB88_10055 ENOG4105C37 (CBS) domain CAB88_10085 ENOG4108Z7R Chaperone CsaA CAB88_10105 ENOG4108ZRV stage ii sporulation protein p CAB88_10120 ENOG4108VXD carboxy-peptidase CAB88_10160 ENOG4108X4Q Hydrolase CAB88_10165 ENOG41082F9 transcriptional regulator CAB88_10170 ENOG4105D94 Major Facilitator Superfamily CAB88_10180 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CAB88_10185 ENOG4107RBS Methyltransferase CAB88_10200 ENOG41087PP glycosyltransferase MGT family CAB88_10205 ENOG4108JYZ YitT family CAB88_10210 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CAB88_10240 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CAB88_10290 ENOG4105KBJ sporulation protein ytfj CAB88_10315 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CAB88_10335 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CAB88_10340 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CAB88_10350 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CAB88_10355 ENOG4105EMN RNA polymerase sigma factor CAB88_10370 ENOG4105CNW domain protein CAB88_10380 ENOG4108V06 Glutathione peroxidase CAB88_10395 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CAB88_10405 ENOG4108IUE nitrate reductase beta subunit CAB88_10410 ENOG4105R3A Nitrate reductase CAB88_10420 ENOG4107V6Q Cyclic nucleotide-binding domain CAB88_10425 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CAB88_10430 ENOG4105D06 uba thif-type nad fad binding protein CAB88_10435 ENOG4105CVM Molybdenum cofactor synthesis domain protein CAB88_10440 ENOG4108ZAF Molybdopterin CAB88_10470 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CAB88_10475 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CAB88_10480 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CAB88_10485 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CAB88_10490 ENOG4108IFG nitrite reductase, (NAD(P)H) CAB88_10495 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CAB88_10530 ENOG4105MCT stage V sporulation protein S CAB88_10560 ENOG4105C5H ABC transporter CAB88_10575 ENOG4108UUM single-stranded DNA-binding protein CAB88_10605 ENOG4107YX5 Pfam:DUF548 CAB88_10610 ENOG4105C75 arginyL-tRNA synthetase CAB88_10625 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CAB88_10650 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CAB88_10660 ENOG4105C5S asparaginyl-tRNA synthetase CAB88_10680 ENOG4105EC2 ftsk spoIIIe CAB88_10765 ENOG4105C8J )-transporter CAB88_10785 ENOG4107XGZ Hydrolase CAB88_10790 ENOG4105CY2 Citrate transporter CAB88_10810 ENOG4105KD7 acetyltransferase CAB88_10820 ENOG4105VMP Transcriptional regulator CAB88_10825 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CAB88_10850 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 CAB88_10865 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) CAB88_10880 ENOG4107RVG penicillin-binding protein CAB88_10890 ENOG4105E9Q Acyl-transferase CAB88_10895 ENOG4108UT2 hemolysin iii CAB88_10905 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CAB88_10920 ENOG4108RCR degv family CAB88_10930 ENOG4108KF3 Electron transport protein SCO1 SenC CAB88_10935 ENOG4107Y70 Heat shock protein CAB88_10940 ENOG4105CAQ asparagine synthetase CAB88_10955 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CAB88_10960 ENOG4108MES Periplasmic binding protein CAB88_10965 ENOG4105F0I Aminotransferase CAB88_10995 ENOG4105D8X mechanosensitive ion channel CAB88_11000 ENOG4105BZU Histidine kinase CAB88_11005 ENOG4105WH1 Two component transcriptional regulator luxr family CAB88_11010 ENOG4106KNT transcriptional regulator CAB88_11015 ENOG4107ZY0 Phenazine biosynthesis-like protein CAB88_11050 ENOG4105CMG Carbohydrate kinase CAB88_11055 ENOG4105C6Z Gluconate CAB88_11065 ENOG4108YV3 Protein of unknown function (DUF2711) CAB88_11095 ENOG4108IJ8 ABC transporter CAB88_11100 ENOG4105E90 ABC transporter CAB88_11135 ENOG4105C37 (CBS) domain CAB88_11165 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CAB88_11180 ENOG4107S4Y M20 DapE family protein YgeY CAB88_11185 ENOG4108TSC N-acetyltransferase CAB88_11190 ENOG4108JUB Transcriptional regulator CAB88_11195 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CAB88_11240 ENOG410841Q phosphoesterase PA-phosphatase related protein CAB88_11250 ENOG4105SZ6 Thioredoxin CAB88_11295 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CAB88_11350 ENOG4105BZ4 penicillin-binding protein CAB88_11360 ENOG4105CZM Major Facilitator CAB88_11365 ENOG4105W8X HesB YadR YfhF-family protein CAB88_11375 ENOG4105DXD 2-methylcitrate dehydratase CAB88_11380 ENOG4105CR4 methylisocitrate lyase CAB88_11385 ENOG4105C1G acyl-Coa dehydrogenase CAB88_11390 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CAB88_11400 ENOG4105N14 lysine exporter protein LysE YggA CAB88_11405 ENOG4105E39 Enoyl-CoA hydratase CAB88_11420 ENOG4107RFY SbcCD D subunit CAB88_11425 ENOG4105EYH Exonuclease CAB88_11450 ENOG4105FCD Major Facilitator CAB88_11460 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CAB88_11465 ENOG4105E4F Isochorismate synthase CAB88_11470 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CAB88_11475 ENOG4105WQI isochorismatase CAB88_11480 ENOG4105CEY Amp-dependent synthetase and ligase CAB88_11485 ENOG4105WQT MbtH domain protein CAB88_11490 ENOG4105C0R drug resistance transporter emrb qaca subfamily CAB88_11505 ENOG4105K70 DNA-binding protein CAB88_11525 ENOG4105BZG amino acid carrier protein CAB88_11545 ENOG4105FE9 pseudouridine synthase CAB88_11550 ENOG4105C22 threonyL-tRNA synthetase CAB88_11555 ENOG4105C19 ABC transporter CAB88_11605 ENOG41081I9 integral membrane protein CAB88_11615 ENOG4108Y4K DNA-binding transcriptional activator CAB88_11630 ENOG4107MII Sugar-specific transcriptional regulator TrmB CAB88_11640 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CAB88_11650 ENOG4105EYF MMPL domain protein CAB88_11675 ENOG4105WCN acetyltransferase CAB88_11700 ENOG4105C1Q protoporphyrinogen oxidase CAB88_11715 ENOG41068WN CAB88_11745 ENOG4107V2S Transcriptional regulator CAB88_11750 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CAB88_11770 ENOG4105DND Transcriptional regulator CAB88_11775 ENOG4108RPX mosc domain containing protein CAB88_11790 ENOG4105BZ1 (ABC) transporter CAB88_11795 ENOG4105BZ1 (ABC) transporter CAB88_11895 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CAB88_11905 ENOG4108IBT Inherit from COG: transposase CAB88_11925 ENOG4108JCI Transcriptional regulator CAB88_11960 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CAB88_11965 ENOG4108KPJ rna polymerase sigma factor CAB88_11995 ENOG4105F32 YngK protein CAB88_12015 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CAB88_12020 ENOG4105RD7 BadF BadG BcrA BcrD CAB88_12025 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CAB88_12035 ENOG4105C7B Threonine dehydratase CAB88_12040 ENOG4108INS Transcriptional regulator CAB88_12055 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CAB88_12065 ENOG4105C1J atp-dependent rna helicase CAB88_12115 ENOG41088CC tellurite resistance protein tehB CAB88_12125 ENOG4108I0C methyltransferase CAB88_12130 ENOG4107RA9 decarboxylase CAB88_12135 ENOG4105K56 Transcriptional regulator CAB88_12140 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CAB88_12185 ENOG4105CIN aminoacyl-histidine dipeptidase CAB88_12220 ENOG4105KRN Transcriptional regulator, abrb family CAB88_12230 ENOG4105EJ9 Membrane CAB88_12235 ENOG4105EQK -acetyltransferase CAB88_12275 ENOG4105W8Z 4'-phosphopantetheinyl transferase CAB88_12300 ENOG4105CSV Glutaminase CAB88_12325 ENOG4108Q8B Spore germination protein CAB88_12330 ENOG4108NHD germination protein CAB88_12335 ENOG4105II7 pyrroline-5-carboxylate reductase CAB88_12340 ENOG4105CUB amino acid CAB88_12345 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CAB88_12370 ENOG41075H3 AraC family transcriptional regulator CAB88_12395 ENOG4105BZU Histidine kinase CAB88_12405 ENOG4107S9D Alpha beta hydrolase CAB88_12470 ENOG41085W3 Transposase CAB88_12485 ENOG4107RVG penicillin-binding protein CAB88_12500 ENOG4105CJN penicillin-binding protein CAB88_12505 ENOG4107RF6 penicillin-binding protein CAB88_12525 ENOG4105DIN metallophosphoesterase CAB88_12535 ENOG4105CJ1 ABC, transporter CAB88_12545 ENOG4107Z3H Transcriptional regulator, TetR family CAB88_12560 ENOG4105C1G acyl-Coa dehydrogenase CAB88_12565 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CAB88_12570 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CAB88_12575 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CAB88_12580 ENOG4105E39 Enoyl-CoA hydratase CAB88_12585 ENOG4107QX3 carboxylase CAB88_12590 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CAB88_12620 ENOG4105DZ1 carboxypeptidase CAB88_12635 ENOG4105T9C HD domain CAB88_12650 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CAB88_12670 ENOG41075H3 AraC family transcriptional regulator CAB88_12700 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CAB88_12710 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CAB88_12780 ENOG4105EFA 4-hydroxyphenylacetate CAB88_12795 ENOG4105CPQ Dehydrogenase CAB88_12805 ENOG410900G Protein of unknown function (DUF421) CAB88_12815 ENOG4108V4B ThiJ pfpI CAB88_12825 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CAB88_12835 ENOG4105DK7 lysyl-tRNA synthetase CAB88_12920 ENOG4105D6E homoserine dehydrogenase CAB88_12930 ENOG4105CPF Cell wall formation (By similarity) CAB88_12935 ENOG4105ETU transcriptional activator (TenA CAB88_12960 ENOG4105VTR Integrase CAB88_13170 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CAB88_13230 ENOG41085W3 Transposase CAB88_13245 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CAB88_13340 ENOG410667J hydrolase CAB88_13345 ENOG4105BZU Histidine kinase CAB88_13350 ENOG4107RF6 penicillin-binding protein CAB88_13375 ENOG4108JJB ABC transporter CAB88_13390 ENOG4108HGU Histidine kinase CAB88_13465 ENOG4105CB2 alcohol dehydrogenase CAB88_13470 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CAB88_13475 ENOG4105CJN penicillin-binding protein CAB88_13535 ENOG4107Y80 Major Facilitator superfamily CAB88_13555 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CAB88_13580 ENOG4107Y9U Membrane CAB88_13625 ENOG4105FCD Major Facilitator CAB88_13635 ENOG4105E09 nadh pyrophosphatase CAB88_13640 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CAB88_13690 ENOG4108XI2 Domain of unknown function (DUF1963) CAB88_13720 ENOG4108NRW Phospholipase, patatin family CAB88_13725 ENOG4105KWG Pfam:DUF1696 CAB88_13760 ENOG4105PKS Excinuclease abc c subunit domain protein CAB88_13800 ENOG4107VFR oxidoreductase CAB88_13825 ENOG4105U0R haloacid dehalogenase-like hydrolase CAB88_13830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_13835 ENOG4105BZU Histidine kinase CAB88_13875 ENOG4107WD8 ABC transporter, permease CAB88_13890 ENOG4105DY8 decarboxylase CAB88_13905 ENOG4108IUM Glycogen debranching enzyme CAB88_13915 ENOG4105CGH 5'-nucleotidase CAB88_13930 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CAB88_13940 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) CAB88_13945 ENOG4105FDR Membrane CAB88_13955 ENOG4105CIS alcohol dehydrogenase CAB88_13960 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CAB88_14005 ENOG4105MSI germination protein ypeb CAB88_14035 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) CAB88_14040 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) CAB88_14045 ENOG4107Z3H Transcriptional regulator, TetR family CAB88_14080 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CAB88_14100 ENOG4105E98 transcriptional regulator DeoR family CAB88_14115 ENOG41062ES Transcriptional regulator CAB88_14135 ENOG4107QKR Dehydrogenase CAB88_14145 ENOG4107RUY (E1 component), alpha subunit CAB88_14155 ENOG4105E1F short-chain dehydrogenase reductase CAB88_14160 ENOG4105RHY Pfam:UPF0157 CAB88_14200 ENOG4107SQ8 Glycine betaine CAB88_14205 ENOG4108IJ7 Glycine betaine CAB88_14230 ENOG4105E66 phosphoriboisomerase A CAB88_14235 ENOG41082BV acetyltransferase CAB88_14240 ENOG4108M1A Chitin-binding protein CAB88_14245 ENOG41087PP glycosyltransferase MGT family CAB88_14270 ENOG4105MSB protein, conserved in bacteria CAB88_14295 ENOG4108Z7F N-acetyltransferase CAB88_14320 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CAB88_14325 ENOG4105EEM helicase CAB88_14350 ENOG4105C9U ATP-dependent DNA helicase RecQ CAB88_14405 ENOG4108M1A Chitin-binding protein CAB88_14425 ENOG4105BZG amino acid carrier protein CAB88_14430 ENOG4105C26 Dehydrogenase CAB88_14435 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CAB88_14440 ENOG4105CTU Proline racemase CAB88_14445 ENOG4105CTU Proline racemase CAB88_14450 ENOG41080HI glycine oxidase CAB88_14460 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein CAB88_14495 ENOG4105DCI Phosphohydrolase CAB88_14500 ENOG4107T5V SNARE associated Golgi CAB88_14510 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CAB88_14530 ENOG4105DTQ mandelate racemase muconate lactonizing CAB88_14545 ENOG4107SET aldo keto reductase CAB88_14575 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CAB88_14580 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CAB88_14585 ENOG4105BZU Histidine kinase CAB88_14590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_14605 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 CAB88_14625 ENOG4105DPN Oligoendopeptidase f CAB88_14630 ENOG4105EPR degv family CAB88_14675 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CAB88_14680 ENOG4106K7D Major facilitator family transporter CAB88_14705 ENOG4107BMA Transglycosylase associated protein CAB88_14720 ENOG41089UC methyltransferase, type 11 CAB88_14760 ENOG4105CHM Aminotransferase CAB88_14775 ENOG4108ZMI UPF0477 protein CAB88_14790 ENOG4105DVE abc transporter atp-binding protein CAB88_14850 ENOG4105C02 permease CAB88_14865 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CAB88_14870 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CAB88_14875 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CAB88_14880 ENOG4105D7T ABC transporter CAB88_14915 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CAB88_14955 ENOG4107VC0 DNA alkylation repair enzyme CAB88_14960 ENOG4105C6T cysteine synthase CAB88_14965 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CAB88_14980 ENOG4107VMI polysaccharide deacetylase CAB88_14990 ENOG4108ZCF integral membrane protein CAB88_14995 ENOG4105E0M Sulfatase CAB88_15000 ENOG4105C5H ABC transporter CAB88_15005 ENOG4105EYF MMPL domain protein CAB88_15010 ENOG41082JN Transcriptional regulator CAB88_15035 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CAB88_15045 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CAB88_15095 ENOG41069ER domain protein CAB88_15110 ENOG4105DNP FAD linked oxidase domain protein CAB88_15135 ENOG4105D4B ABC, transporter CAB88_15140 ENOG4105F5R ABC transporter CAB88_15145 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CAB88_15155 ENOG4105DKT Transcriptional regulator CAB88_15160 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CAB88_15170 ENOG41061GT Aldolase CAB88_15180 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CAB88_15190 ENOG4105YVS arsR family transcriptional regulator CAB88_15215 ENOG4105II7 pyrroline-5-carboxylate reductase CAB88_15225 ENOG4107258 Transcriptional regulator CAB88_15255 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CAB88_15265 ENOG4105ECK Fatty Acid Desaturase CAB88_15275 ENOG4107RBI VanW family CAB88_15280 ENOG4105G6Z alkaline phosphatase CAB88_15290 ENOG4105VMP Transcriptional regulator CAB88_15310 ENOG41068WN CAB88_15340 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CAB88_15360 ENOG4105C8Y Acetylornithine aminotransferase CAB88_15400 ENOG4108TVJ Nitroreductase CAB88_15405 ENOG4105FS7 Transcriptional regulator CAB88_15430 ENOG4105WEC Molybdate metabolism regulator CAB88_15435 ENOG4105CMR udp-glucose 4-epimerase CAB88_15460 ENOG4108DMH HTH_ARAC CAB88_15465 ENOG4108XET gCN5-related N-acetyltransferase CAB88_15480 ENOG4108PCN EamA-like transporter family CAB88_15530 ENOG410635A Membrane CAB88_15540 ENOG4108IQI permease CAB88_15550 ENOG4105F1N DNA alkylation repair CAB88_15560 ENOG4105BZU Histidine kinase CAB88_15565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_15575 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CAB88_15610 ENOG4107RF6 penicillin-binding protein CAB88_15615 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CAB88_15620 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CAB88_15635 ENOG4105E7W lamb ycsf family protein CAB88_15645 ENOG4105P4J Allophanate hydrolase, subunit 1 CAB88_15650 ENOG4107258 Transcriptional regulator CAB88_15665 ENOG4106N3A copper homeostasis protein cutc CAB88_15670 ENOG4108ZHR arsR family transcriptional regulator CAB88_15680 ENOG4105FDT acyl-CoA dehydrogenase CAB88_15695 ENOG4105DWD nucleoside recognition domain protein CAB88_15750 ENOG4105CGH 5'-nucleotidase CAB88_15760 ENOG4105CHJ isochorismatase hydrolase CAB88_15785 ENOG41090MY MarR family Transcriptional regulator CAB88_15855 ENOG4108606 TspO/MBR family CAB88_15860 ENOG4105CVP deoxyribo-dipyrimidine photolyase CAB88_15875 ENOG4108TWJ NADH dehydrogenase subunit 5 CAB88_15880 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CAB88_15885 ENOG4107VMI polysaccharide deacetylase CAB88_15890 ENOG4105KY5 gCN5-related N-acetyltransferase CAB88_15895 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CAB88_15905 ENOG4105D6J arsenicaL-resistance protein CAB88_15910 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CAB88_15915 ENOG41085FC arsR family transcriptional regulator CAB88_15930 ENOG4105NAE bifunctional deaminase-reductase domain protein CAB88_15940 ENOG4108IG5 Transcriptional regulator CAB88_15990 ENOG4105F27 Major Facilitator CAB88_15995 ENOG4105M4P Tetr family transcriptional regulator CAB88_16000 ENOG4105CHR reductase CAB88_16005 ENOG4108YXU transcriptional regulator AsnC family CAB88_16060 ENOG4105N0V mono-oxygenase ydhR CAB88_16090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_16095 ENOG41062D9 Histidine kinase CAB88_16170 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CAB88_16175 ENOG4105C0R drug resistance transporter emrb qaca subfamily CAB88_16200 ENOG4105K6H D-cysteine desulfhydrase CAB88_16230 ENOG4105E0Y RtcB Protein CAB88_16240 ENOG4105JQZ Methyltransferase CAB88_16255 ENOG4105DNP FAD linked oxidase domain protein CAB88_16265 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CAB88_16285 ENOG4105BZU Histidine kinase CAB88_16295 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CAB88_16310 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CAB88_16330 ENOG4108JQ1 Dehydrogenase CAB88_16335 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CAB88_16350 ENOG41082W1 Cupin 2, conserved barrel domain protein CAB88_16360 ENOG410874W AraC family transcriptional regulator CAB88_16380 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CAB88_16400 ENOG4108VXD carboxy-peptidase CAB88_16405 ENOG4105PNM synthesis protein CAB88_16415 ENOG4108ISG Major Facilitator CAB88_16430 ENOG4107MII Sugar-specific transcriptional regulator TrmB CAB88_16435 ENOG4105CZM Major Facilitator CAB88_16460 ENOG4105CRW Short chain fatty acid transporter CAB88_16470 ENOG4105DYS nad(p)h dehydrogenase (quinone) CAB88_16530 ENOG4108K8S endonuclease I CAB88_16540 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CAB88_16550 ENOG41067QW Transcriptional regulator CAB88_16565 ENOG4108Z66 YbaK ebsC protein CAB88_16570 ENOG4105CUT histidyl-tRNA synthetase CAB88_16585 ENOG4105KVH Transcriptional regulator CAB88_16590 ENOG4108RCM Nitroreductase CAB88_16625 ENOG4108PSK reductase CAB88_16705 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CAB88_16710 ENOG4105DKQ ROK family CAB88_16720 ENOG4108UW5 maltose o-acetyltransferase CAB88_16725 ENOG4105C31 Tryptophanyl-tRNA synthetase CAB88_16730 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CAB88_16760 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CAB88_16770 ENOG4105EV4 Multidrug resistance protein mdtH CAB88_16795 ENOG4105C37 (CBS) domain CAB88_16810 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CAB88_16815 ENOG4105FAW cDP-glucose 4,6-dehydratase CAB88_16845 ENOG4105DDN Pentapeptide repeat-containing protein CAB88_16850 ENOG4105XDF Protein of unknown function (DUF1272) CAB88_16855 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CAB88_16860 ENOG4105CMG Carbohydrate kinase CAB88_16865 ENOG4105C6Z Gluconate CAB88_16880 ENOG4105CV1 Transketolase (EC 2.2.1.1) CAB88_16885 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CAB88_16890 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CAB88_16895 ENOG4105CIS alcohol dehydrogenase CAB88_16900 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CAB88_16915 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CAB88_16930 ENOG4105C8Q Methyl-accepting chemotaxis CAB88_16935 ENOG4108UX3 '-nucleotidase CAB88_16945 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CAB88_16950 ENOG4105KVH Transcriptional regulator CAB88_16965 ENOG4105CV8 reductase CAB88_16970 ENOG4105F27 Major Facilitator CAB88_16980 ENOG41090KN UPF0303 protein CAB88_17000 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CAB88_17005 ENOG4105CHH sulfate transporter CAB88_17020 ENOG4105C44 Serine transporter CAB88_17060 ENOG4105KVH Transcriptional regulator CAB88_17065 ENOG4108TZY GntR Family Transcriptional Regulator CAB88_17075 ENOG4105D9R oxidoreductase CAB88_17080 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CAB88_17085 ENOG4105KVH Transcriptional regulator CAB88_17090 ENOG4105KVH Transcriptional regulator CAB88_17140 ENOG4105JAB phenazine biosynthesis protein, phzf family CAB88_17150 ENOG4105CHR reductase CAB88_17165 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CAB88_17170 ENOG4105KVH Transcriptional regulator CAB88_17185 ENOG4108ZJ4 polysaccharide deacetylase CAB88_17260 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CAB88_17275 ENOG4107YXZ hydrolase, family 25 CAB88_17310 ENOG4105H3G oxidoreductase CAB88_17385 ENOG4108TN2 lmbE family CAB88_17395 ENOG4107R3E Citrate transporter CAB88_17410 ENOG4108MES Periplasmic binding protein CAB88_17415 ENOG4105EHG Permease protein CAB88_17420 ENOG4105DQ5 transport system permease protein CAB88_17425 ENOG4105NX3 Membrane CAB88_17445 ENOG4107CUJ Protein of unknown function (DUF2690) CAB88_17460 ENOG4107V2S Transcriptional regulator CAB88_17480 ENOG4105C98 muts2 protein CAB88_17490 ENOG4105E5K Alpha-amylase CAB88_17495 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CAB88_17520 ENOG4105FFC UPF0187 protein CAB88_17535 ENOG4108A04 Beta-lactamase CAB88_17560 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CAB88_17570 ENOG41082BM Transcriptional regulator, arsr family CAB88_17575 ENOG4105CB2 alcohol dehydrogenase CAB88_17585 ENOG4107JM4 Tetratricopeptide repeat CAB88_17615 ENOG4105CQB FAD linked oxidase domain protein CAB88_17645 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C CAB88_17650 ENOG4108M1A Chitin-binding protein CAB88_17665 ENOG4105E1K spore germination protein CAB88_17705 ENOG4105BZU Histidine kinase CAB88_17710 ENOG4105C5H ABC transporter CAB88_17715 ENOG41067SE Tetr family transcriptional regulator CAB88_17720 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity CAB88_17730 ENOG4108VXD carboxy-peptidase CAB88_17735 ENOG4107DUR UPF0457 protein CAB88_17755 ENOG4105BZU Histidine kinase CAB88_17765 ENOG4105KT7 mgtC SapB transporter CAB88_17780 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CAB88_17785 ENOG4105EAB amino acid AbC transporter CAB88_17795 ENOG4108HW4 amino acid AbC transporter CAB88_17800 ENOG41073R8 VanW family CAB88_17810 ENOG4108R1P CAB88_17830 ENOG4105VEQ Cold shock protein CAB88_17850 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CAB88_17870 ENOG410904N short-chain dehydrogenase reductase CAB88_17880 ENOG4106IQC argininosuccinate lyase CAB88_17895 ENOG4108IA2 Sodium pantothenate symporter CAB88_17905 ENOG4105C26 Dehydrogenase CAB88_17910 ENOG4105CHR reductase CAB88_17920 ENOG4105EWU Squalene--hopene cyclase CAB88_17930 ENOG4105FR1 rard protein CAB88_17935 ENOG410696E Membrane CAB88_17950 ENOG4105D1F ATP-binding protein CAB88_17960 ENOG4108ZAF Molybdopterin CAB88_17965 ENOG4105CVM Molybdenum cofactor synthesis domain protein CAB88_17970 ENOG4105D06 uba thif-type nad fad binding protein CAB88_17975 ENOG4105TMB Formate nitrite transporter CAB88_17990 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CAB88_17995 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CAB88_18005 ENOG4108JB9 formate dehydrogenase CAB88_18015 ENOG4105E1K spore germination protein CAB88_18030 ENOG4105CUB amino acid CAB88_18090 ENOG4108KGH TRANSCRIPTIONal CAB88_18100 ENOG4105EMN RNA polymerase sigma factor CAB88_18110 ENOG4105CIG ABC transporter CAB88_18130 ENOG4105D9R oxidoreductase CAB88_18140 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CAB88_18150 ENOG4105K4P CoA-binding domain protein CAB88_18155 ENOG4105C0H protease CAB88_18160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_18170 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CAB88_18175 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CAB88_18180 ENOG4105W8X HesB YadR YfhF-family protein CAB88_18210 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CAB88_18215 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CAB88_18225 ENOG4108JJA ABC, transporter CAB88_18230 ENOG4108I0Z Aconitate hydratase CAB88_18260 ENOG4105E5W Transporter CAB88_18270 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CAB88_18290 ENOG4107F3J Amp-dependent synthetase and ligase CAB88_18295 ENOG4107ZYJ bioY protein CAB88_18300 ENOG4105CEY Amp-dependent synthetase and ligase CAB88_18305 ENOG4108IMY Transcriptional regulator CAB88_18340 ENOG4107AYK membrAne CAB88_18355 ENOG4105BZU Histidine kinase CAB88_18360 ENOG4105FBA Phospholipase Carboxylesterase CAB88_18365 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CAB88_18370 ENOG4105CK7 Sodium proline symporter CAB88_18375 ENOG4105CBC glutamate synthase CAB88_18380 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CAB88_18385 ENOG4108VJ1 Transcriptional regulator (CarD family CAB88_18390 ENOG4108903 Formimidoylglutamase CAB88_18415 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CAB88_18450 ENOG4107QIV Cytochrome c biogenesis protein CAB88_18465 ENOG4105CH2 amidohydrolase CAB88_18475 ENOG4105CJ1 ABC, transporter CAB88_18490 ENOG4107RSM transcriptional regulator CAB88_18495 ENOG4105VAW lrga family CAB88_18500 ENOG41067MG lrgb family CAB88_18540 ENOG4105BZ1 (ABC) transporter CAB88_18545 ENOG4105BZ1 (ABC) transporter CAB88_18580 ENOG4108HW3 (ABC) transporter CAB88_18585 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CAB88_18605 ENOG4108SVB resolvase CAB88_18625 ENOG4105K7K Transcriptional regulator CAB88_18630 ENOG4105C5F glutamine synthetase CAB88_18635 ENOG4105KV4 Transcriptional regulator CAB88_18640 ENOG4105CXI aluminum resistance protein CAB88_18645 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CAB88_18650 ENOG4105EN6 Membrane CAB88_18655 ENOG4106F1P AAA ATPase, central domain protein CAB88_18690 ENOG41069ER domain protein CAB88_18700 ENOG4105DM4 PTS System CAB88_18705 ENOG4105DE4 1-phosphofructokinase CAB88_18710 ENOG4105E98 transcriptional regulator DeoR family CAB88_18715 ENOG4107QW4 alcohol dehydrogenase CAB88_18720 ENOG4108SJC Membrane CAB88_18735 ENOG4105C85 amino acid CAB88_18760 ENOG4105TMB Formate nitrite transporter CAB88_18765 ENOG4105K70 DNA-binding protein CAB88_18775 ENOG4105C59 p-type ATPase CAB88_18780 ENOG410681U heavy metal transport detoxification protein CAB88_18785 ENOG4105VPX protein, conserved in bacteria CAB88_18805 ENOG4105NIV Esterase CAB88_18810 ENOG4105E0A ABC, transporter CAB88_18830 ENOG4105CGK Exodeoxyribonuclease III CAB88_18840 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CAB88_18845 ENOG4105D03 DNA-3-methyladenine glycosylase II CAB88_18875 ENOG4105BZU Histidine kinase CAB88_18915 ENOG41067MG lrgb family CAB88_18935 ENOG4108S3Y transcriptional regulator CAB88_18940 ENOG4105CS2 ec 3.2.1.21 CAB88_18955 ENOG4105F0V Cell wall hydrolase CAB88_18970 ENOG4105E0M Sulfatase CAB88_18975 ENOG410890F Dynamin family CAB88_19010 ENOG4105DQU oxidoreductase, subunit beta CAB88_19015 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CAB88_19020 ENOG4108IGT Dipeptidase CAB88_19025 ENOG4105MCT stage V sporulation protein S CAB88_19030 ENOG4105D48 metallophosphoesterase CAB88_19055 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CAB88_19070 ENOG4105XZV Protein of unknown function (DUF3243) CAB88_19075 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CAB88_19095 ENOG4105UIB (ABC) transporter CAB88_19100 ENOG4108JQ9 ABC transporter CAB88_19105 ENOG4105DIH basic membrane CAB88_19110 ENOG4105FDP GntR family transcriptional regulator CAB88_19120 ENOG4105CNU cell division protein FtsK CAB88_19130 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CAB88_19140 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CAB88_19150 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CAB88_19155 ENOG4108S0H Dipicolinic acid synthetase, b subunit CAB88_19200 ENOG41085W3 Transposase CAB88_19365 ENOG4105CDU Replicative dna helicase CAB88_19400 ENOG4108IMY Transcriptional regulator CAB88_19425 ENOG4108S0H Dipicolinic acid synthetase, b subunit CAB88_19430 ENOG4105E35 Dipicolinate synthase subunit A CAB88_19440 ENOG4105C1V Peptidase, M16 CAB88_19460 ENOG4105DTN riboflavin biosynthesis protein ribF CAB88_19475 ENOG4105W7A Protein of unknown function (DUF503) CAB88_19485 ENOG4105VHM ribosomal protein CAB88_19490 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CAB88_19495 ENOG4105CHV Transcription elongation factor NusA CAB88_19505 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CAB88_19515 ENOG4105DZP Membrane-associated zinc metalloprotease CAB88_19520 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CAB88_19525 ENOG4105KNE Phosphatidate cytidylyltransferase CAB88_19530 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CAB88_19540 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CAB88_19570 ENOG4108HE4 integrase family CAB88_19580 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CAB88_19585 ENOG4105C79 DNA protecting protein DprA CAB88_19590 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CAB88_19605 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CAB88_19630 ENOG4105VB6 UPF0109 protein CAB88_19650 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CAB88_19655 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CAB88_19670 ENOG4105CHR reductase CAB88_19675 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CAB88_19690 ENOG4105CB5 ATP-dependent DNA helicase recG CAB88_19695 ENOG4105DP4 dak2 domain fusion protein ylov CAB88_19700 ENOG4108ZAA Alkaline-shock protein CAB88_19715 ENOG4105FJ0 thiamine CAB88_19720 ENOG4105DJV ribulose-phosphate 3-epimerase CAB88_19725 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CAB88_19730 ENOG4105D9P serine threonine protein kinase CAB88_19735 ENOG4108ZF3 Phosphatase CAB88_19745 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CAB88_19760 ENOG4105C25 Primosomal protein n' CAB88_19765 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CAB88_19785 ENOG4105DSJ YicC domain protein CAB88_19795 ENOG4105F23 Fibronectin-binding protein CAB88_19805 ENOG4105DC7 peptidase M24 CAB88_19855 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CAB88_19890 ENOG4105C34 Pseudouridine synthase CAB88_19905 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CAB88_19915 ENOG4105DBK s4 domain protein CAB88_19920 ENOG41067XK integral membrane protein CAB88_19930 ENOG4105DFA alanine racemase domain protein CAB88_19935 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CAB88_19940 ENOG4105WR5 sporulation protein, YlmC YmxH family CAB88_19950 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAB88_19960 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CAB88_19965 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CAB88_19975 ENOG4105D4A Cell wall formation (By similarity) CAB88_19980 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CAB88_19985 ENOG4105CNI cell division protein FtsW CAB88_20000 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CAB88_20005 ENOG4105CJN penicillin-binding protein CAB88_20010 ENOG4105CJN penicillin-binding protein CAB88_20025 ENOG41074B2 UPF0747 protein CAB88_20050 ENOG4105KNH Nucleic acid-binding protein CAB88_20060 ENOG41063PX domain protein CAB88_20065 ENOG4105D78 K07001 NTE family protein CAB88_20070 ENOG4105H20 Sporulation integral membrane protein YlbJ CAB88_20080 ENOG4106H78 methyltransferase CAB88_20100 ENOG4107TB6 phosphoglycerate mutase CAB88_20115 ENOG4106UY4 Inherit from COG: Scp-like extracellular CAB88_20135 ENOG4105EKQ RNA-directed DNA polymerase CAB88_20180 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CAB88_20190 ENOG4105CNI cell division protein FtsW CAB88_20205 ENOG4108IAB Phoh family CAB88_20225 ENOG4105QA2 CAB88_20230 ENOG4105CI3 gtp-binding protein typa CAB88_20240 ENOG4105ECY inositol monophosphatase CAB88_20260 ENOG4105CXN decarboxylase CAB88_20310 ENOG4105CPP Dehydrogenase, E1 component CAB88_20325 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CAB88_20330 ENOG4108X4Q Hydrolase CAB88_20345 ENOG4105CN5 Metallo-Beta-Lactamase CAB88_20350 ENOG4107ZYR domain protein CAB88_20385 ENOG4108XRC Protein of unknown function (DUF458) CAB88_20395 ENOG4107IN1 Protein of unknown function (DUF1797) CAB88_20410 ENOG4105EPM Diguanylate phosphodiesterase CAB88_20415 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CAB88_20430 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CAB88_20440 ENOG4105UIN CAB88_20475 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CAB88_20500 ENOG4108HGU Histidine kinase CAB88_20510 ENOG4105CHM Aminotransferase CAB88_20520 ENOG4105EG2 ABC transporter, permease CAB88_20530 ENOG4107FKK extracellular solute-binding protein family 1 CAB88_20540 ENOG4105CG3 alpha amylase, catalytic region CAB88_20585 ENOG4105CHU acetyl-coa acetyltransferase CAB88_20620 ENOG4105K7K Transcriptional regulator CAB88_20625 ENOG4105DTD Dehydrogenase CAB88_20645 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CAB88_20670 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CAB88_20685 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CAB88_20695 ENOG4105BZU Histidine kinase CAB88_20715 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CAB88_20730 ENOG4105CID antiterminator CAB88_20740 ENOG4105FDP GntR family transcriptional regulator CAB88_20750 ENOG4105CE4 GlcNAc 6-P deacetylase CAB88_20790 ENOG4107ZE5 PPIases accelerate the folding of proteins CAB88_20795 ENOG4105PTM secreted protein CAB88_20800 ENOG4105J7I hydrolase CAB88_20810 ENOG4105G6R Stage v sporulation protein ae CAB88_20820 ENOG4105CZ3 stage V sporulation protein ad CAB88_20825 ENOG41090VF Stage v sporulation protein ac CAB88_20845 ENOG4105C8J )-transporter CAB88_20850 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAB88_20860 ENOG41082AN stage II sporulation protein CAB88_20865 ENOG4105DZ1 carboxypeptidase CAB88_20875 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CAB88_20880 ENOG4105DVE abc transporter atp-binding protein CAB88_20915 ENOG4105D7N magnesium and cobalt transport protein CorA CAB88_20940 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CAB88_20950 ENOG4105I3K Ferric uptake regulator, Fur family CAB88_20955 ENOG4105MZ9 stage II sporulation protein m CAB88_20975 ENOG4105CPC Aldo Keto reductase CAB88_20985 ENOG4105RHY Pfam:UPF0157 CAB88_21005 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CAB88_21015 ENOG4105ETE Transcriptional regulator (LacI family CAB88_21020 ENOG4108YM7 Gcn5-related n-acetyltransferase CAB88_21040 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CAB88_21045 ENOG4108R6K riboflavin synthase, subunit alpha CAB88_21070 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CAB88_21075 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CAB88_21090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CAB88_21105 ENOG4105DFD Na H antiporter CAB88_21110 ENOG4105CGH 5'-nucleotidase CAB88_21165 ENOG4105DBV ornithine carbamoyltransferase CAB88_21180 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CAB88_21195 ENOG4108IXY short-chain dehydrogenase reductase CAB88_21200 ENOG41069FQ Metallo-beta-lactamase superfamily CAB88_21205 ENOG4105II7 pyrroline-5-carboxylate reductase CAB88_21210 ENOG4105EJQ L-serine dehydratase CAB88_21240 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CAB88_21260 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CAB88_21265 ENOG4105D9U N-acetyltransferase CAB88_21280 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CAB88_21285 ENOG4108QEG Membrane CAB88_21290 ENOG4105CDA abc transporter atp-binding protein CAB88_21295 ENOG4105E5Q amino acid AbC transporter CAB88_21300 ENOG4108HW3 (ABC) transporter CAB88_21310 ENOG4105G7B Protein of unknown function (DUF2992) CAB88_21320 ENOG4108QY0 Membrane CAB88_21335 ENOG4105C7S Dehydrogenase CAB88_21340 ENOG4105CPP Dehydrogenase, E1 component CAB88_21355 ENOG4105CKM Branched-chain carboxylic acid kinase CAB88_21360 ENOG4107RDP Dehydrogenase CAB88_21375 ENOG4108JUB Transcriptional regulator CAB88_21385 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CAB88_21400 ENOG4107QQR Sporulation CAB88_21410 ENOG4105S1Z Stage IV sporulation protein B CAB88_21415 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CAB88_21420 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CAB88_21425 ENOG4105DX0 Hemolysin A CAB88_21435 ENOG4105CTB Polyprenyl synthetase CAB88_21450 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CAB88_21460 ENOG4108ZSR alkaline shock protein CAB88_21465 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CAB88_21490 ENOG410644B Stage III sporulation protein af CAB88_21500 ENOG4105KQ4 Stage iii sporulation protein ad CAB88_21505 ENOG4108CQH stage III sporulation protein AC CAB88_21510 ENOG4105KR5 Stage iii sporulation protein CAB88_21515 ENOG4105CD2 stage iii sporulation protein aa CAB88_21540 ENOG4105DC7 peptidase M24 CAB88_21545 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CAB88_21555 ENOG4105CBJ Metal-dependent enzyme CAB88_21565 ENOG4107YBY Hydrolase CAB88_21595 ENOG41082GG biotin lipoate A B protein ligase CAB88_21600 ENOG4105WZW rhodanese family CAB88_21625 ENOG41080TC multidrug resistance protein CAB88_21665 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CAB88_21680 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CAB88_21700 ENOG4105C0D helicase CAB88_21790 ENOG4107R6U sodium dicarboxylate symporter CAB88_21830 ENOG4105D7V transposase CAB88_21835 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CAB88_21840 ENOG4105C3R Methionine synthase CAB88_21850 ENOG4105C28 cystathionine CAB88_21855 ENOG4105C28 cystathionine CAB88_21875 ENOG4105C5X domain protein CAB88_21885 ENOG4105DKQ ROK family CAB88_21895 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CAB88_21910 ENOG4108UTW Plays a role in the regulation of phosphate uptake CAB88_21915 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CAB88_21920 ENOG4105C8U phosphate abc transporter CAB88_21925 ENOG4105C8U phosphate abc transporter CAB88_21930 ENOG4105EXS phosphate abc transporter CAB88_21935 ENOG4107RF6 penicillin-binding protein CAB88_21945 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CAB88_21970 ENOG4105N80 Ferric uptake regulator, Fur family CAB88_21980 ENOG4105FDK ABC transporter CAB88_21985 ENOG4108JYZ YitT family CAB88_21990 ENOG41069ZM Protein of unknown function (DUF2624) CAB88_22015 ENOG4105EGD dinuclear metal center protein, YbgI family CAB88_22030 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAB88_22035 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CAB88_22070 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CAB88_22075 ENOG4105KG3 cytidine deaminase CAB88_22080 ENOG4107YR5 Diacylglycerol kinase CAB88_22085 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CAB88_22090 ENOG4105CTJ Metal Dependent Phosphohydrolase CAB88_22095 ENOG4105C9A Phoh family CAB88_22105 ENOG41068P3 sporulation protein YqfC CAB88_22115 ENOG4105KTH gatB Yqey CAB88_22130 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CAB88_22135 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CAB88_22165 ENOG4105CSA Coproporphyrinogen iii oxidase CAB88_22170 ENOG4105KVH Transcriptional regulator CAB88_22195 ENOG4105TQK DNA polymerase iii, delta' subunit CAB88_22205 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CAB88_22210 ENOG4108UK2 deaminase CAB88_22215 ENOG4105KQC Competence protein CAB88_22225 ENOG4105DXX methyltransferase CAB88_22235 ENOG4108WF2 Metal Dependent Phosphohydrolase CAB88_22245 ENOG410812S Rna-binding protein CAB88_22255 ENOG4105CQW ribosome biogenesis GTPase YqeH CAB88_22260 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CAB88_22275 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAB88_22295 ENOG4108TVJ Nitroreductase CAB88_22310 ENOG4105G6Z alkaline phosphatase CAB88_22315 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CAB88_22320 ENOG4108MUZ hydrolase CAB88_22355 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CAB88_22360 ENOG4105MIR Phenylalanine 4-monooxygenase CAB88_22370 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CAB88_22415 ENOG4105S6R Iron-hydroxamate transporter permease subunit CAB88_22420 ENOG4108V5C ABC transporter CAB88_22435 ENOG4108EKI Dehydrogenase CAB88_22440 ENOG4105C28 cystathionine CAB88_22470 ENOG4107XRG penicillin-binding protein CAB88_22475 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CAB88_22485 ENOG4105CFP Peptidase U32 CAB88_22490 ENOG4105XYU peptidase (U32 family) CAB88_22495 ENOG4108VQJ O-methyltransferase CAB88_22500 ENOG4105HHA aminodeoxychorismate lyase CAB88_22520 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CAB88_22530 ENOG4105C02 permease CAB88_22545 ENOG41060CR CAB88_22550 ENOG4105C7H Helicase, RecD TraA family CAB88_22560 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CAB88_22565 ENOG4105C3J Cysteine desulfurase CAB88_22575 ENOG4105D1H recombination factor protein RarA CAB88_22580 ENOG4108VCI transcription factor, rsfa family CAB88_22595 ENOG4105CUZ uba thif-type nad fad binding protein CAB88_22605 ENOG4105CUT histidyl-tRNA synthetase CAB88_22615 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CAB88_22620 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CAB88_22630 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CAB88_22635 ENOG41076HS cation diffusion facilitator family transporter CAB88_22640 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CAB88_22650 ENOG4105CKP Polysaccharide Biosynthesis Protein CAB88_22655 ENOG4108QG2 Membrane CAB88_22665 ENOG4105VIE preprotein translocase, subunit YajC CAB88_22680 ENOG41061AI Protein of unknown function (DUF2905) CAB88_22695 ENOG4108HUF Transporter CAB88_22725 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CAB88_22730 ENOG4108IYU L-aspartate oxidase CAB88_22745 ENOG4108RPX mosc domain containing protein CAB88_22750 ENOG4105CQC Prephenate dehydratase CAB88_22765 ENOG4105C19 ABC transporter CAB88_22770 ENOG4105EWM Histidine kinase CAB88_22780 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CAB88_22795 ENOG4105X36 (ribosomal) protein CAB88_22805 ENOG4105C03 ribonuclease CAB88_22820 ENOG4107QMS site-determining protein CAB88_22835 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CAB88_22840 ENOG4105DFF Rod shape-determining protein mreb CAB88_22865 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CAB88_22870 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CAB88_22880 ENOG41068KH stage VI sporulation protein D CAB88_22890 ENOG4105D52 delta-aminolevulinic acid dehydratase CAB88_22915 ENOG4105K56 Transcriptional regulator CAB88_22935 ENOG4108IUQ atp-dependent protease CAB88_22965 ENOG4108QCI YvbH-like oligomerisation region CAB88_23080 ENOG4105M59 Phosphodiesterase, mj0936 family CAB88_23085 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CAB88_23095 ENOG4108XJQ germination protein CAB88_23105 ENOG4108PCX Major Facilitator CAB88_23115 ENOG4105KBX Transcriptional regulator, TetR family CAB88_23125 ENOG4105PFC Transcriptional regulator CAB88_23135 ENOG4105DZC cytosine deaminase CAB88_23140 ENOG41067S9 phage shock protein C, PspC CAB88_23145 ENOG4108JCI Transcriptional regulator CAB88_23155 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CAB88_23160 ENOG4108Z40 Transcriptional regulator CAB88_23165 ENOG4105RHA ABC transporter, permease CAB88_23170 ENOG4108IUX (ABC) transporter CAB88_23175 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CAB88_23180 ENOG4105ER2 Ompa motb domain protein CAB88_23185 ENOG4105E14 MotA TolQ exbB proton channel CAB88_23195 ENOG4108VXD carboxy-peptidase CAB88_23205 ENOG4105E33 succinate dehydrogenase CAB88_23215 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CAB88_23225 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CAB88_23230 ENOG4105K63 Thioredoxin CAB88_23235 ENOG4105C10 Electron transfer flavoprotein CAB88_23240 ENOG4105BZJ Electron transfer flavoprotein CAB88_23245 ENOG41060WC Enoyl-CoA hydratase CAB88_23250 ENOG4107Z3H Transcriptional regulator, TetR family CAB88_23255 ENOG4105CEY Amp-dependent synthetase and ligase CAB88_23270 ENOG4105J76 Periplasmic binding protein CAB88_23275 ENOG4105S6R Iron-hydroxamate transporter permease subunit CAB88_23325 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CAB88_23340 ENOG4105DR4 Methyltransferase CAB88_23350 ENOG4105KFN sortase, SrtB family CAB88_23355 ENOG4105E0A ABC, transporter CAB88_23370 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CAB88_23380 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) CAB88_23390 ENOG4105FE9 pseudouridine synthase CAB88_23405 ENOG4105DCG PHP domain protein CAB88_23420 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CAB88_23440 ENOG4105C5S asparaginyl-tRNA synthetase CAB88_23445 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CAB88_23455 ENOG4108RWN rrna methyltransferase CAB88_23485 ENOG4105C0R drug resistance transporter emrb qaca subfamily CAB88_23490 ENOG4105CW7 secretion protein, HlyD family CAB88_23495 ENOG4108JGH Tetr family transcriptional regulator CAB88_23500 ENOG4105CN9 Peptidase m42 family protein CAB88_23520 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CAB88_23525 ENOG4105C22 threonyL-tRNA synthetase CAB88_23530 ENOG4108TDW sporulation protein YtxC CAB88_23555 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CAB88_23565 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CAB88_23570 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CAB88_23580 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CAB88_23585 ENOG4105C2M dna polymerase I CAB88_23590 ENOG4105BZU Histidine kinase CAB88_23595 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CAB88_23620 ENOG4108HMX isocitrate dehydrogenase (NADP) CAB88_23625 ENOG4105BZN citrate synthase CAB88_23640 ENOG4108REF Sporulation integral membrane protein ytvi CAB88_23645 ENOG4105FS0 cytoplasmic membrane protein CAB88_23670 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CAB88_23675 ENOG4105C6K Malic enzyme CAB88_23680 ENOG4105C0B DNA polymerase III (alpha subunit) CAB88_23685 ENOG4105VV2 CAB88_23695 ENOG4105SFS phosphoesterase RecJ domain protein CAB88_23725 ENOG4105DC7 peptidase M24 CAB88_23760 ENOG4105Z7P Acetyltransferase (GNAT) family CAB88_23765 ENOG41082W1 Cupin 2, conserved barrel domain protein CAB88_23785 ENOG4107YZX Universal stress protein CAB88_23830 ENOG4108JYZ YitT family CAB88_23850 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CAB88_23860 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CAB88_23865 ENOG4105KBJ sporulation protein ytfj CAB88_23880 ENOG4105EFZ amidohydrolase CAB88_23890 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CAB88_23915 ENOG4105RQF LysR family Transcriptional regulator CAB88_23925 ENOG4105U5Y Transcriptional regulator CAB88_23935 ENOG4105C28 cystathionine CAB88_23970 ENOG4105EMN RNA polymerase sigma factor CAB88_23980 ENOG4108UW5 maltose o-acetyltransferase CAB88_23990 ENOG4105F1V Acetoin utilization protein CAB88_23995 ENOG4105W87 Cbs domain CAB88_24000 ENOG4105DGU Histone deacetylase CAB88_24005 ENOG4106HB6 Alpha beta hydrolase CAB88_24015 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CAB88_24020 ENOG4105BZU Histidine kinase CAB88_24025 ENOG4107SNB ankyrin repeat protein YahD CAB88_24030 ENOG4105EP9 oxidoreductase CAB88_24055 ENOG4105ETE Transcriptional regulator (LacI family CAB88_24085 ENOG4105C88 aminopeptidase CAB88_24110 ENOG4108IPJ Membrane CAB88_24145 ENOG4108VDD TRNA binding domain protein CAB88_24175 ENOG4105C8F Beta-lactamase domain protein CAB88_24190 ENOG4108V15 phosphotransferase enzyme family CAB88_24195 ENOG4108IUM Glycogen debranching enzyme CAB88_24205 ENOG4107QSE Dipeptidase CAB88_24210 ENOG4105YW5 deoR family transcriptional regulator CAB88_24225 ENOG4105CBX hi0933 family CAB88_24270 ENOG4108VJ1 Transcriptional regulator (CarD family CAB88_24275 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CAB88_24280 ENOG4105CSC Glucose uptake protein CAB88_24295 ENOG4108ZAF Molybdopterin CAB88_24300 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CAB88_24305 ENOG4105CVM Molybdenum cofactor synthesis domain protein CAB88_24315 ENOG4105D06 uba thif-type nad fad binding protein CAB88_24320 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CAB88_24340 ENOG41085GJ domain protein CAB88_24350 ENOG4105DWV Homoserine O-trans-acetylase CAB88_24360 ENOG4108B31 Spore germination protein CAB88_24385 ENOG4105C8T Leucyl-tRNA synthetase CAB88_24390 ENOG410605W Major Facilitator CAB88_24395 ENOG4107S91 Sodium hydrogen exchanger CAB88_24400 ENOG4105NCW Trka-c domain protein CAB88_24420 ENOG4105C19 ABC transporter CAB88_24430 ENOG4105D7V transposase CAB88_24450 ENOG4105N5T Radical SAM Protein CAB88_24460 ENOG4105DA5 (ABC) transporter CAB88_24495 ENOG4105E8V Alpha Beta Hydrolase Fold protein CAB88_24500 ENOG4108Z0R Transferase CAB88_24505 ENOG4105YVM Phosphoesterase, PA-phosphatase related CAB88_24510 ENOG4105BZF Glycosyl transferase (Group 1 CAB88_24520 ENOG4105EPU Molybdenum cofactor synthesis domain protein CAB88_24605 ENOG4105BZU Histidine kinase CAB88_24610 ENOG4105BZU Histidine kinase CAB88_24615 ENOG4105CH6 catalase CAB88_24620 ENOG4107S9D Alpha beta hydrolase CAB88_24625 ENOG4107T7U Sulfatase CAB88_24650 ENOG4105D2X ABC transporter substrate-binding protein CAB88_24660 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CAB88_24720 ENOG41080TC multidrug resistance protein CAB88_24725 ENOG410839T multidrug resistance protein CAB88_24745 ENOG4108V2W Carbonate dehydratase CAB88_24750 ENOG4105C4M (Ubiquinol oxidase) subunit I CAB88_24755 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CAB88_24790 ENOG41087YS Phage shock protein A CAB88_24815 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CAB88_24820 ENOG4105BZU Histidine kinase CAB88_24825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_24850 ENOG4108UGV hypoxanthine phosphoribosyltransferase CAB88_24855 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CAB88_24870 ENOG4105C19 ABC transporter CAB88_24885 ENOG4107ZTW SNARE associated Golgi CAB88_24900 ENOG4105C19 ABC transporter CAB88_24905 ENOG41086D8 Transcriptional regulator CAB88_24920 ENOG41082BM Transcriptional regulator, arsr family CAB88_24970 ENOG4105C6Z Gluconate CAB88_24975 ENOG4105FDP GntR family transcriptional regulator CAB88_24995 ENOG41069H0 dihydroorotase EC 3.5.2.3 CAB88_25020 ENOG4105DTQ mandelate racemase muconate lactonizing CAB88_25025 ENOG4105CEY Amp-dependent synthetase and ligase CAB88_25030 ENOG4108IPT Naphthoate synthase CAB88_25035 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CAB88_25040 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CAB88_25045 ENOG4105E4F Isochorismate synthase CAB88_25050 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CAB88_25060 ENOG4105VEQ Cold shock protein CAB88_25105 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CAB88_25110 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CAB88_25120 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CAB88_25270 ENOG4105KT7 mgtC SapB transporter CAB88_25275 ENOG4107PBV potassium channel CAB88_25295 ENOG4105WG9 Conserved Protein CAB88_25305 ENOG4105CHM Aminotransferase CAB88_25310 ENOG4108ZB6 transcriptional regulator AsnC family CAB88_25315 ENOG4105C5I Dehydrogenase CAB88_25320 ENOG4108MUZ hydrolase CAB88_25330 ENOG4105C87 Aminotransferase class I and II CAB88_25345 ENOG4105Y38 Kinase-associated protein B CAB88_25355 ENOG4107R3E Citrate transporter CAB88_25375 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CAB88_25380 ENOG4105KA0 thioesterase Superfamily protein CAB88_25395 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CAB88_25420 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CAB88_25425 ENOG4106YN8 Prenyltransferase CAB88_25435 ENOG41069ER domain protein CAB88_25450 ENOG4105CEP NADH dehydrogenase CAB88_25480 ENOG4105EWC Purine nucleoside phosphorylase CAB88_25535 ENOG4105XSJ toxin secretion phage lysis holin CAB88_25680 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAB88_25705 ENOG4108ZUE Phage regulatory protein rha CAB88_25725 ENOG4108IMY Transcriptional regulator CAB88_25760 ENOG4108VQJ O-methyltransferase CAB88_25780 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CAB88_25805 ENOG4108JJA ABC, transporter CAB88_25810 ENOG4105C4B ABC transporter, permease CAB88_25815 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CAB88_25845 ENOG41083MR nifu domain-containing protein CAB88_25865 ENOG4108W5N phosphatidylglycerophosphatase a CAB88_25885 ENOG4105DAX Pfam:DUF2983 CAB88_25895 ENOG4105DYS nad(p)h dehydrogenase (quinone) CAB88_25900 ENOG4105D4U had-superfamily hydrolase, subfamily iia CAB88_25915 ENOG4105CBT Fructose-1,6-bisphosphatase CAB88_25940 ENOG4105MMD transcriptional regulator CAB88_25945 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CAB88_25950 ENOG4107TXC Transcriptional regulator CAB88_25955 ENOG41090T1 Membrane CAB88_25980 ENOG4105FAA peptidase M23 CAB88_25985 ENOG4108YTE sporulation protein YunB CAB88_25990 ENOG4105KZD Domain of unknown function (DUF1805) CAB88_25995 ENOG4107R8B 5'-nucleotidase CAB88_26000 ENOG4105DIW FeS assembly protein SUFB CAB88_26005 ENOG4108UNV SUF system FeS assembly protein, NifU family CAB88_26010 ENOG4105C9B Cysteine desulfurase CAB88_26015 ENOG4105JRK feS assembly protein SufD CAB88_26020 ENOG4105C3K feS assembly ATPase SufC CAB88_26025 ENOG4105D01 (LipO)protein CAB88_26030 ENOG4105D01 (LipO)protein CAB88_26035 ENOG4108UMI ABC transporter, permease CAB88_26040 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CAB88_26065 ENOG41080E8 Transcriptional regulator, Spx MgsR family CAB88_26105 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CAB88_26130 ENOG4108W8B Beta-lactamase domain protein CAB88_26135 ENOG4105C1G acyl-Coa dehydrogenase CAB88_26140 ENOG4105CHU acetyl-coa acetyltransferase CAB88_26155 ENOG4105DZ1 carboxypeptidase CAB88_26175 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CAB88_26190 ENOG4108SUT Major Facilitator Superfamily CAB88_26195 ENOG4107R7I amino acid CAB88_26210 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CAB88_26220 ENOG4107AYK membrAne CAB88_26260 ENOG4107ZTW SNARE associated Golgi CAB88_26270 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CAB88_26275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_26280 ENOG4105BZU Histidine kinase CAB88_26305 ENOG4105C8Q Methyl-accepting chemotaxis CAB88_26310 ENOG4105C8Q Methyl-accepting chemotaxis CAB88_26315 ENOG4105VG1 fes assembly suf system protein CAB88_26320 ENOG4105D4Y metalloprotease CAB88_26325 ENOG4105C2I pirin domain protein CAB88_26340 ENOG4107T5V SNARE associated Golgi CAB88_26345 ENOG4107S91 Sodium hydrogen exchanger CAB88_26350 ENOG4105NCW Trka-c domain protein CAB88_26365 ENOG4108RMU ferritin dps family protein CAB88_26385 ENOG4108URH decarboxylase CAB88_26395 ENOG41090A1 ferritin CAB88_26405 ENOG4105D9N nucleoside CAB88_26410 ENOG4105D9N nucleoside CAB88_26425 ENOG4108RYK Nad-dependent epimerase dehydratase CAB88_26445 ENOG4105CV8 reductase CAB88_26450 ENOG4105F27 Major Facilitator CAB88_26455 ENOG4105KVH Transcriptional regulator CAB88_26470 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CAB88_26475 ENOG4105D4A Cell wall formation (By similarity) CAB88_26500 ENOG4105WMR Protein CrcB homolog CAB88_26505 ENOG4105WMR Protein CrcB homolog CAB88_26520 ENOG4108MK9 spermidine N(1)-acetyltransferase CAB88_26525 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CAB88_26535 ENOG4108W2Y isochorismatase CAB88_26565 ENOG4108IPW abc transporter atp-binding protein CAB88_26570 ENOG4105CM4 permease protein CAB88_26605 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CAB88_26615 ENOG4105XZU Preprotein translocase, subunit SecG CAB88_26620 ENOG41067MG lrgb family CAB88_26670 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAB88_26680 ENOG4105BZU Histidine kinase CAB88_26685 ENOG4108W5X Transcriptional Regulator, LuxR family CAB88_26705 ENOG41090VF Stage v sporulation protein ac CAB88_26710 ENOG4105CZ3 stage V sporulation protein ad CAB88_26725 ENOG4108QY0 Membrane CAB88_26730 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CAB88_26735 ENOG4105KRI phosphocarrier protein (HPr CAB88_26745 ENOG4105CHW UPF0052 protein CAB88_26750 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CAB88_26755 ENOG4108Z4K mutator MutT protein CAB88_26765 ENOG4105C3M thioredoxin reductase CAB88_26775 ENOG4108S4C acetyltransferase CAB88_26795 ENOG41086DT Membrane protein of unknown function CAB88_26805 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CAB88_26825 ENOG4107TXC Transcriptional regulator CAB88_26845 ENOG4105DUM transcriptional regulator, lysR family CAB88_26855 ENOG4108WS4 fmn reductase CAB88_26860 ENOG4105C5H ABC transporter CAB88_26870 ENOG4105BZ1 (ABC) transporter CAB88_26885 ENOG4105CN1 protease CAB88_26890 ENOG4105CRP Part of the ABC transporter FtsEX involved in CAB88_26895 ENOG4105CAK Cell division ATP-binding protein ftsE CAB88_26910 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CAB88_26925 ENOG4105MS2 ribosomal subunit Interface protein CAB88_26930 ENOG4105VEQ Cold shock protein CAB88_26935 ENOG41081UC Inherit from COG: Competence protein CAB88_26950 ENOG4105KVH Transcriptional regulator CAB88_26965 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CAB88_26970 ENOG4108KGH TRANSCRIPTIONal CAB88_26975 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CAB88_26980 ENOG4105C6Y Udp-glucose 6-dehydrogenase CAB88_26985 ENOG4105ESV Glycosyl transferase, family 4 CAB88_26995 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CAB88_27015 ENOG4105F8D glycoside hydrolase family 4 CAB88_27020 ENOG4105VCP PTS System CAB88_27025 ENOG4105CK1 PTS System CAB88_27035 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CAB88_27040 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CAB88_27045 ENOG4105VCP PTS System CAB88_27055 ENOG4105VZJ PTS System CAB88_27075 ENOG4105ECB domain protein CAB88_27080 ENOG4107RSM transcriptional regulator CAB88_27140 ENOG4105DAA L-lactate CAB88_27150 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) CAB88_27165 ENOG4105E0M Sulfatase CAB88_27195 ENOG4107R8N Glycosyl transferase, family 2 CAB88_27205 ENOG4105C94 Transporter CAB88_27215 ENOG41069ER domain protein CAB88_27240 ENOG4105KBK Zinc finger, swim domain protein CAB88_27245 ENOG4105C0D helicase CAB88_27255 ENOG41085W3 Transposase CAB88_27285 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAB88_27295 ENOG4107RBB ABC transporter, permease CAB88_27300 ENOG4105C19 ABC transporter CAB88_27320 ENOG4105CXY transporter CAB88_27335 ENOG4105BZU Histidine kinase CAB88_27340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_27345 ENOG4105DG6 mannose-6-phosphate isomerase CAB88_27350 ENOG4105DM4 PTS System CAB88_27360 ENOG4105CMR udp-glucose 4-epimerase CAB88_27370 ENOG4108KGH TRANSCRIPTIONal CAB88_27375 ENOG4105DG6 mannose-6-phosphate isomerase CAB88_27380 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CAB88_27390 ENOG4107T8Q Glycosyl transferase (Group 1 CAB88_27395 ENOG4107EF8 Glycosyl transferase (Group 1 CAB88_27405 ENOG4107RA4 Glycosyl transferase (Group 1 CAB88_27410 ENOG4108UW5 maltose o-acetyltransferase CAB88_27425 ENOG4105D3Q Sugar transferase CAB88_27430 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CAB88_27435 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CAB88_27440 ENOG4107YJ4 chain length determinant protein CAB88_27445 ENOG4105HTX biosynthesis protein CAB88_27450 ENOG4107YJ4 chain length determinant protein CAB88_27465 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CAB88_27480 ENOG4105FRN stage II sporulation protein CAB88_27495 ENOG4105DY9 regulatoR CAB88_27515 ENOG4106778 Protein of unknown function (DUF1146) CAB88_27520 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CAB88_27525 ENOG4105C8S subunit m CAB88_27530 ENOG4105D65 subunit l CAB88_27555 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CAB88_27560 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CAB88_27570 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CAB88_27575 ENOG4105BZU Histidine kinase CAB88_27625 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CAB88_27630 ENOG41062M3 atp synthase CAB88_27650 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CAB88_27660 ENOG4108UIC UPF0340 protein CAB88_27665 ENOG4108YZG isomerase CAB88_27685 ENOG4108VGI doxx family CAB88_27690 ENOG4107XC4 flavin reductase domain protein, FMN-binding CAB88_27710 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CAB88_27720 ENOG4108ZXQ stage ii sporulation protein r CAB88_27725 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CAB88_27730 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CAB88_27750 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CAB88_27755 ENOG4105CBT Fructose-1,6-bisphosphatase CAB88_27765 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CAB88_27785 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CAB88_27800 ENOG4105C1G acyl-Coa dehydrogenase CAB88_27805 ENOG4105C1G acyl-Coa dehydrogenase CAB88_27810 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CAB88_27820 ENOG4105DF6 Fe-S oxidoreductase CAB88_27835 ENOG4105BZU Histidine kinase CAB88_27850 ENOG4105D4Y metalloprotease CAB88_27860 ENOG4105BZU Histidine kinase CAB88_27865 ENOG4105KCT ABC transporter CAB88_27870 ENOG4108M15 ABC transporter CAB88_27875 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CAB88_27885 ENOG4105IIU Aminopeptidase CAB88_27905 ENOG4105EMN RNA polymerase sigma factor CAB88_27920 ENOG410684U Domain of unknown function (DUF1934) CAB88_27945 ENOG4105CYW agmatinase CAB88_27955 ENOG4105DXB Major Facilitator superfamily CAB88_27960 ENOG4107SWG transcriptional regulator MERR family CAB88_27965 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CAB88_27970 ENOG4105BZ4 penicillin-binding protein CAB88_27975 ENOG4108XFG YwhD family CAB88_27980 ENOG4108Z4T Peptidase M50 CAB88_27985 ENOG41069HH 4-oxalocrotonate tautomerase CAB88_27990 ENOG4105DCI Phosphohydrolase CAB88_27995 ENOG4108MES Periplasmic binding protein CAB88_28000 ENOG4105E0A ABC, transporter CAB88_28005 ENOG4105EHG Permease protein CAB88_28010 ENOG4105DQ5 transport system permease protein CAB88_28020 ENOG4108VCI transcription factor, rsfa family CAB88_28025 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CAB88_28030 ENOG4108IJ2 phosphate acetyltransferase CAB88_28035 ENOG4107UEZ chlorite dismutase CAB88_28045 ENOG4108VKI Cell wall hydrolase CAB88_28065 ENOG4107SVH Potassium channel protein CAB88_28075 ENOG410667J hydrolase CAB88_28080 ENOG4105VCH membrane CAB88_28090 ENOG4108TU7 Inherit from COG: (ABC) transporter CAB88_28095 ENOG4105CJ1 ABC, transporter CAB88_28100 ENOG41090WU lipolytic protein G-D-S-L family CAB88_28115 ENOG4105D6E homoserine dehydrogenase CAB88_28120 ENOG4105CVG Homoserine O-transsuccinylase CAB88_28140 ENOG4108Y4K DNA-binding transcriptional activator CAB88_28150 ENOG4105WH1 Two component transcriptional regulator luxr family CAB88_28155 ENOG4105BZU Histidine kinase CAB88_28160 ENOG4105DWF phosphomethylpyrimidine kinase CAB88_28165 ENOG4105BZU Histidine kinase CAB88_28170 ENOG4105VCD cytoplasmic protein CAB88_28175 ENOG4105D22 carbon starvation protein CAB88_28180 ENOG4105DY9 regulatoR CAB88_28185 ENOG41079KZ Major Facilitator Superfamily CAB88_28200 ENOG4105CG5 Glycosyl transferase (Group 1 CAB88_28210 ENOG4105EN6 Membrane CAB88_28215 ENOG4106YBV Methyl-accepting chemotaxis CAB88_28225 ENOG4108S4H thioesterase Superfamily protein CAB88_28230 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CAB88_28240 ENOG4105K64 Glycosyl transferase, family 2 CAB88_28250 ENOG4105EJV Membrane CAB88_28255 ENOG4105CKK Glycosyl transferase, family 2 CAB88_28265 ENOG4108IG5 Transcriptional regulator CAB88_28270 ENOG4105C5H ABC transporter CAB88_28275 ENOG41067SE Tetr family transcriptional regulator CAB88_28285 ENOG4105E0X reductase CAB88_28290 ENOG4106F5Q Membrane CAB88_28305 ENOG4108NEV two component transcriptional regulator, LytTR family CAB88_28310 ENOG4108HRK Histidine kinase CAB88_28315 ENOG4107RGD Major Facilitator superfamily CAB88_28335 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CAB88_28345 ENOG4105IW1 AmiS UreI transporter CAB88_28355 ENOG4105CMR udp-glucose 4-epimerase CAB88_28360 ENOG4108UT2 hemolysin iii CAB88_28370 ENOG4105C1J atp-dependent rna helicase CAB88_28380 ENOG4105DPN Oligoendopeptidase f CAB88_28390 ENOG4105BZU Histidine kinase CAB88_28405 ENOG4105C0H protease CAB88_28410 ENOG4105Q2H domain protein CAB88_28425 ENOG4105BZU Histidine kinase CAB88_28430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAB88_28455 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CAB88_28460 ENOG4105CDU Replicative dna helicase CAB88_28470 ENOG4105BZR domain protein CAB88_28475 ENOG4108XMW Membrane CAB88_28485 ENOG4108UUM single-stranded DNA-binding protein CAB88_28495 ENOG4105C3G gtp-binding protein CAB88_28500 ENOG4105VDK protein, conserved in bacteria CAB88_28505 ENOG4105D8X mechanosensitive ion channel CAB88_28510 ENOG4108ZDA Sporulation protein YyaC CAB88_28515 ENOG4105FA0 parb-like partition protein CAB88_28520 ENOG4107QJE Chromosome Partitioning Protein CAB88_28535 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CAB88_28540 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CAB88_28550 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CAB88_28570 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CAB88_28575 ENOG410848D S4 domain protein YaaA CAB88_28590 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CAB88_28625 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CAB88_28660 ENOG4105ZMH deoxynucleoside kinase CAB88_28670 ENOG4105GTG Isochorismatase CAB88_28680 ENOG4108Z6B deaminase CAB88_28690 ENOG4105C6E dna polymerase iii CAB88_28715 ENOG41067KS pro-sigma K processing CAB88_28750 ENOG4105CXN decarboxylase CAB88_28760 ENOG4105FA2 dna polymerase iii CAB88_28765 ENOG4105MA4 psp1 domain protein CAB88_28775 ENOG41060K3 Methyltransferase CAB88_28785 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CAB88_28790 ENOG4105KRN Transcriptional regulator, abrb family CAB88_28795 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CAB88_28800 ENOG4105F8V Hydrolase, tatD family CAB88_28805 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CAB88_28815 ENOG4105XFA sporulation peptidase YabG CAB88_28820 ENOG4105W42 Veg protein CAB88_28835 ENOG4105DFT pur operon repressor CAB88_28845 ENOG4105KME endoribonuclease L-psp CAB88_28860 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CAB88_28865 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CAB88_28875 ENOG4108JA2 transcriptioN-repair coupling factor CAB88_28880 ENOG4108M14 stage v sporulation protein t CAB88_28890 ENOG4108IY2 MazG family CAB88_28895 ENOG41082I2 s4 domain protein CAB88_28900 ENOG4105VYY sporulation protein yabp CAB88_28915 ENOG41060GV RNA binding s1 domain protein CAB88_28935 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CAB88_28940 ENOG4108UGV hypoxanthine phosphoribosyltransferase CAB88_28945 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CAB88_28960 ENOG4105C6T cysteine synthase CAB88_28965 ENOG4105CRQ synthase (Component I) CAB88_28970 ENOG4105DDQ anthranilate synthase CAB88_28975 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CAB88_28980 ENOG4105EEI dihydropteroate synthase CAB88_28985 ENOG4105KRF dihydroneopterin aldolase CAB88_28990 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CAB88_29000 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CAB88_29115 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CAB88_29120 ENOG4105EKQ RNA-directed DNA polymerase CAB88_29175 ENOG4107QZI cell division protein FtsK CAB88_29180 ENOG4105EKQ RNA-directed DNA polymerase CAB88_29190 ENOG4105EKQ RNA-directed DNA polymerase CAB88_29350 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CAB88_29440 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CAB88_29480 ENOG4105EKQ RNA-directed DNA polymerase CAB88_29500 ENOG4105EKQ RNA-directed DNA polymerase CAB88_29520 ENOG4105EKQ RNA-directed DNA polymerase CAB88_29530 ENOG4105EKQ RNA-directed DNA polymerase CAB88_29570 ENOG4105DHF Membrane CAB88_29615 ENOG4108NGU Transcriptional regulator CAB88_29630 ENOG4105CUB amino acid CAB88_29640 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CAB88_29650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CAB88_29660 ENOG4108U05 Transcriptional regulator CAB88_29665 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 CAB88_29685 ENOG4105DND Transcriptional regulator CAB88_29700 ENOG4105CAQ asparagine synthetase CAB88_29705 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CAB88_29730 ENOG41087PP glycosyltransferase MGT family CAB88_29740 ENOG4107SWG transcriptional regulator MERR family CAB88_29760 ENOG4105EKQ RNA-directed DNA polymerase CAB88_29770 ENOG4105E1J oxidoreductase CAB88_29775 ENOG4107RT3 EamA-like transporter family CAB88_29785 ENOG4107S1E Beta-lactamase CAB88_29825 ENOG4105K70 DNA-binding protein CAB88_29830 ENOG4105KRN Transcriptional regulator, abrb family CAB88_29855 ENOG41085W3 Transposase CAB88_29870 ENOG4105D7V transposase CAB88_29875 ENOG4108UZ3 Transporter CAB88_29885 ENOG4105DRR Transcriptional regulator, GntR family CAB88_29890 ENOG4108UZ3 Transporter CAB88_29900 ENOG4105E5W Transporter CAB88_29905 ENOG4105CUJ penicillin amidase CAB88_29955 ENOG4105CIF Ornithine Cyclodeaminase CAB88_29970 ENOG4105K70 DNA-binding protein CAB88_29985 ENOG4105KRN Transcriptional regulator, abrb family CAB88_29990 ENOG4108KS4 Spore coat protein CAB88_29995 ENOG4107SBE Glycosyl transferase (Group 1 CAB88_30015 ENOG4107SBE Glycosyl transferase (Group 1 CAB88_30020 ENOG4108IAJ Nad-dependent epimerase dehydratase CAB88_30035 ENOG4105DUX Transporter CAB88_30045 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CAB88_30055 ENOG4105CHR reductase CAB88_30075 ENOG4105D7V transposase CAB88_30090 ENOG4105FQP Beta-lactamase CAB88_30145 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CAB88_30160 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CAB88_30200 ENOG4108JGH Tetr family transcriptional regulator CAB88_30205 ENOG4105EQ0 Major Facilitator superfamily CAB88_30215 ENOG4105EJQ L-serine dehydratase CAB88_30220 ENOG4105C44 Serine transporter CAB88_30235 ENOG4105C8Q Methyl-accepting chemotaxis CAB88_30255 ENOG4108IG5 Transcriptional regulator CAB88_30280 ENOG4108VJ1 Transcriptional regulator (CarD family CAB88_30310 ENOG4105DRR Transcriptional regulator, GntR family CAB88_30325 ENOG4105FQP Beta-lactamase CAB88_30330 ENOG4105CNI cell division protein FtsW CAB88_30340 ENOG4105CJW magnesium transporter CAB88_30355 ENOG4108E1C hydrolase CAB88_30395 ENOG4105D4Y metalloprotease CAB88_30400 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) CAB88_30440 ENOG4105BZU Histidine kinase CAB88_30445 ENOG4105EFI regulatoR CAB88_30465 ENOG4108IND Tetr family transcriptional regulator CAB88_30495 ENOG4105CEY Amp-dependent synthetase and ligase CAB88_30520 ENOG4107Y80 Major Facilitator superfamily CAB88_30540 ENOG4105CJZ response regulator CAB88_30570 ENOG41085GJ domain protein CAB88_30575 ENOG4105CEP NADH dehydrogenase CAB88_30620 ENOG4105D2T synthase CAB88_30635 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) CAB88_30640 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CAB88_30645 ENOG4105C1B dTDP-glucose 4-6-dehydratase CAB88_30650 ENOG4105C5E polysaccharide biosynthesis protein CAB88_30735 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CAB88_30810 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CAB88_30825 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CAB88_30830 ENOG4107QPK )-transporter CAB88_30860 ENOG4108MRH transcriptional regulatory protein CAB88_30980 ENOG4105D4Y metalloprotease CAB88_31005 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CAB88_31010 ENOG4108FPN Integrase CAB88_31015 ENOG4108KU9 integrase family CAB88_31060 ENOG4105BZU Histidine kinase CAB88_31120 ENOG4105CJ1 ABC, transporter CAB88_31125 ENOG4105BZ1 (ABC) transporter CAB88_31145 ENOG41067FT ParB-like nuclease domain CAB88_31160 ENOG4105D7V transposase CAB88_31185 ENOG4105TRI Hydrolase CAB88_31225 ENOG4105IBP Cyclic peptide transporter CAB88_31230 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CAB88_31235 ENOG4105C0W non-ribosomal peptide synthetase CAB88_31250 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) CAB88_31255 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CAB88_31270 ENOG4105C1G acyl-Coa dehydrogenase CAB88_31290 ENOG4105C0W non-ribosomal peptide synthetase CAB88_31290 ENOG4105C0W non-ribosomal peptide synthetase CAB88_31300 ENOG4105D7V transposase CAB88_31315 ENOG41069ER domain protein CAB88_31340 ENOG4105D7V transposase CAB88_31355 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CAB88_31370 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CAB88_31375 ENOG4105DR5 peptidase CAB88_31415 ENOG4105IIU Aminopeptidase CAB88_31440 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CAB88_31465 ENOG4108WZA zeta toxin CAB88_31470 ENOG4105M6F mutator MutT protein CAB88_31475 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CAB88_31505 ENOG4105YWU small acid-soluble spore protein CAB88_31535 ENOG4105BZ1 (ABC) transporter CAB88_31635 ENOG4105EKQ RNA-directed DNA polymerase CAB88_31705 ENOG4105DR5 peptidase CAB88_32000 ENOG4108KU9 integrase family CAB88_32005 ENOG4108FPN Integrase CAB88_32010 ENOG4105K70 DNA-binding protein CAB88_32030 ENOG4105D7V transposase CAB88_32060 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) CAB88_32070 ENOG4105E2X shikimate dehydrogenase CAB88_32110 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CAB88_32180 ENOG4105K4H Nlp p60 protein CAB88_32265 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CAB88_32450 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CAB88_32470 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CAB88_32480 ENOG41085W3 Transposase CAB88_32635 ENOG4105EKQ RNA-directed DNA polymerase CAB88_32655 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CAB88_32920 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CAB88_32950 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CAB88_33035 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CAB88_33165 ENOG4108KU9 integrase family CAB88_33170 ENOG4108FPN Integrase CAB88_33205 ENOG4105EKQ RNA-directed DNA polymerase CAB88_33240 ENOG4105K4H Nlp p60 protein