locus-tag class description B7P25_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B7P25_00025 ENOG410848D S4 domain protein YaaA B7P25_00040 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7P25_00075 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) B7P25_00110 ENOG4105ZMH deoxynucleoside kinase B7P25_00120 ENOG4105GTG Isochorismatase B7P25_00130 ENOG4108Z6B deaminase B7P25_00140 ENOG4105C6E dna polymerase iii B7P25_00195 ENOG4105CXN decarboxylase B7P25_00205 ENOG4105FA2 dna polymerase iii B7P25_00210 ENOG4105MA4 psp1 domain protein B7P25_00220 ENOG41060K3 Methyltransferase B7P25_00230 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) B7P25_00235 ENOG4105KRN Transcriptional regulator, abrb family B7P25_00245 ENOG4105F8V Hydrolase, tatD family B7P25_00250 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) B7P25_00260 ENOG4105XFA sporulation peptidase YabG B7P25_00265 ENOG4105W42 Veg protein B7P25_00280 ENOG4105DFT pur operon repressor B7P25_00290 ENOG4105KME endoribonuclease L-psp B7P25_00305 ENOG4105C5T Phosphoribosyl pyrophosphate synthase B7P25_00310 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) B7P25_00320 ENOG4108JA2 transcriptioN-repair coupling factor B7P25_00325 ENOG4108M14 stage v sporulation protein t B7P25_00335 ENOG4108IY2 MazG family B7P25_00340 ENOG41082I2 s4 domain protein B7P25_00345 ENOG4105VYY sporulation protein yabp B7P25_00360 ENOG41060GV RNA binding s1 domain protein B7P25_00385 ENOG4108UGV hypoxanthine phosphoribosyltransferase B7P25_00390 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B7P25_00405 ENOG4105C6T cysteine synthase B7P25_00410 ENOG4105CRQ synthase (Component I) B7P25_00415 ENOG4105DDQ anthranilate synthase B7P25_00425 ENOG4105EEI dihydropteroate synthase B7P25_00430 ENOG4105KRF dihydroneopterin aldolase B7P25_00435 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B7P25_00445 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) B7P25_00550 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) B7P25_00580 ENOG4105D7W serine acetyltransferase B7P25_00595 ENOG4105C2N RNA methyltransferase TrmH family group 3 B7P25_00600 ENOG4105M0M Tetracycline resistance protein B7P25_00605 ENOG4105QIV RNA polymerase B7P25_00620 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) B7P25_00645 ENOG4107Y49 methyltransferase B7P25_00765 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) B7P25_00790 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B7P25_00810 ENOG41067V7 50S ribosomal protein L36 B7P25_00840 ENOG4108JJB ABC transporter B7P25_00845 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) B7P25_00850 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B7P25_00875 ENOG4105D1F ATP-binding protein B7P25_00890 ENOG4108NMV polysaccharide deacetylase B7P25_00970 ENOG4105C8B TIGR00159 family B7P25_00975 ENOG4107U5W ybbr family B7P25_01000 ENOG4105IIP Membrane B7P25_01010 ENOG4108VQT Alpha beta hydrolase fold protein B7P25_01020 ENOG4105CMG Carbohydrate kinase B7P25_01030 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) B7P25_01035 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein B7P25_01060 ENOG4108PSK reductase B7P25_01065 ENOG4108UMI ABC transporter, permease B7P25_01070 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B7P25_01075 ENOG4105D01 (LipO)protein B7P25_01080 ENOG4105EE1 crotonyl-CoA reductase B7P25_01090 ENOG4105IQ5 FAD linked oxidase domain protein B7P25_01105 ENOG4105C2C drug resistance transporter, Bcr CflA B7P25_01120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B7P25_01125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7P25_01130 ENOG4105C3U ABC transporter B7P25_01135 ENOG4108JQ7 (ABC) transporter B7P25_01165 ENOG4108J59 Extracellular solute-binding protein, family 5 B7P25_01170 ENOG4108J59 Extracellular solute-binding protein, family 5 B7P25_01180 ENOG4105II7 pyrroline-5-carboxylate reductase B7P25_01190 ENOG4107XDY Nicotinamide Mononucleotide Transporter B7P25_01200 ENOG4105E0C molybdate abc transporter B7P25_01205 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein B7P25_01210 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family B7P25_01245 ENOG4105F6E Acyl-transferase B7P25_01265 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B7P25_01280 ENOG4108RE7 deoxyribonuclease B7P25_01290 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) B7P25_01315 ENOG4105C5H ABC transporter B7P25_01330 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B7P25_01340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7P25_01345 ENOG4105C3U ABC transporter B7P25_01350 ENOG4108JQ7 (ABC) transporter B7P25_01355 ENOG410667J hydrolase B7P25_01390 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase B7P25_01395 ENOG4105ERH Fumarylacetoacetate hydrolase B7P25_01410 ENOG4108SC4 )-transporter B7P25_01415 ENOG4105CPF Cell wall formation (By similarity) B7P25_01420 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) B7P25_01435 ENOG4107ZXI Rhomboid family B7P25_01445 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein B7P25_01450 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B7P25_01460 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) B7P25_01560 ENOG4105K8N protein family UPF0079, ATPase B7P25_01565 ENOG41072GX Peptidase M22 Glycoprotease B7P25_01570 ENOG410801F ribosomal-protein-alanine acetyltransferase B7P25_01580 ENOG4105C5H ABC transporter B7P25_01595 ENOG4108TYN CAAX amino terminal protease family protein B7P25_01615 ENOG4105C7N Xanthine uracil vitamin C permease B7P25_01625 ENOG4105BZU Histidine kinase B7P25_01650 ENOG4107ZXU DSBA oxidoreductase B7P25_01700 ENOG4108SHN Glycosyl transferase, family 2 B7P25_01745 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7P25_01765 ENOG4105SX7 Transporter B7P25_01795 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) B7P25_01800 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit B7P25_01805 ENOG4105C83 adenylosuccinate lyase B7P25_01815 ENOG4105VR9 phosphoribosylformylglycinamidine synthase B7P25_01840 ENOG4108V3E phosphoribosylglycinamide formyltransferase B7P25_01850 ENOG4105C12 Phosphoribosylglycinamide synthetase B7P25_01880 ENOG4105C4R Atp-dependent dna helicase B7P25_01910 ENOG4108W2Y isochorismatase B7P25_01920 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B7P25_01925 ENOG4108UMI ABC transporter, permease B7P25_01930 ENOG4105D01 (LipO)protein B7P25_01950 ENOG410834F Transcriptional regulator B7P25_01955 ENOG4107I77 yiaA/B two helix domain B7P25_01975 ENOG4105CBD Diacylglycerol kinase B7P25_01980 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) B7P25_01985 ENOG4108JPW Aminotransferase B7P25_01995 ENOG4105C26 Dehydrogenase B7P25_02000 ENOG4105KPY Small multidrug resistance protein B7P25_02020 ENOG4105D9N nucleoside B7P25_02025 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B7P25_02035 ENOG4105BZU Histidine kinase B7P25_02040 ENOG4108W15 Protein of unknown function (DUF1456) B7P25_02055 ENOG4105DTQ mandelate racemase muconate lactonizing B7P25_02065 ENOG4105DFD Na H antiporter B7P25_02085 ENOG4105D3R alkyl hydroperoxide reductase B7P25_02090 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) B7P25_02100 ENOG4107W7X Aldolase B7P25_02105 ENOG4105EHG Permease protein B7P25_02110 ENOG4105DQ5 transport system permease protein B7P25_02115 ENOG4108V5C ABC transporter B7P25_02145 ENOG4106UIA B7P25_02150 ENOG4106UIA B7P25_02180 ENOG4105BZU Histidine kinase B7P25_02200 ENOG410756H nucleotidyltransferase B7P25_02205 ENOG4105D2S major facilitator superfamily B7P25_02220 ENOG4105E5Q amino acid AbC transporter B7P25_02225 ENOG4105EAB amino acid AbC transporter B7P25_02240 ENOG4105C8Q Methyl-accepting chemotaxis B7P25_02245 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B7P25_02255 ENOG4105CI1 PTS System B7P25_02285 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter B7P25_02300 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component B7P25_02315 ENOG4105C5H ABC transporter B7P25_02345 ENOG41062JF Transcriptional regulator B7P25_02365 ENOG4105DEU major facilitator superfamily B7P25_02400 ENOG4108N0M stress protein B7P25_02405 ENOG4106FN3 tellurium resistance protein B7P25_02410 ENOG4106FN3 tellurium resistance protein B7P25_02415 ENOG4107TS3 membrane protein, TerC B7P25_02420 ENOG4108TTB tellurium resistance protein B7P25_02440 ENOG4105KJF protein tyrosine phosphatase B7P25_02450 ENOG4107U9T Pfam:Ribonuclease_BN B7P25_02460 ENOG4105C59 p-type ATPase B7P25_02465 ENOG4108IPJ Membrane B7P25_02475 ENOG4105C3F Signal peptidase i B7P25_02485 ENOG4107ZTW SNARE associated Golgi B7P25_02500 ENOG410606W general stress protein B7P25_02505 ENOG4105UPD Calcium Proton B7P25_02540 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B7P25_02545 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B7P25_02555 ENOG4108JUB Transcriptional regulator B7P25_02565 ENOG4108IQI permease B7P25_02600 ENOG4105CSV Glutaminase B7P25_02615 ENOG4108A04 Beta-lactamase B7P25_02630 ENOG4105CKK Glycosyl transferase, family 2 B7P25_02635 ENOG4107QQG Dehydrogenase B7P25_02640 ENOG4105C3I Nad-dependent epimerase dehydratase B7P25_02660 ENOG4105F1A Pyruvate formate-lyase B7P25_02680 ENOG4105CI2 imidazolone-5-propionate hydrolase B7P25_02685 ENOG4105ECP epimerase B7P25_02715 ENOG41067AE Membrane-bound metal-dependent hydrolase B7P25_02720 ENOG4105CEN a g-specific adenine glycosylase B7P25_02725 ENOG4106BXE B7P25_02745 ENOG4105BZ1 (ABC) transporter B7P25_02750 ENOG4107NBY Membrane B7P25_02755 ENOG4105CBC glutamate synthase B7P25_02765 ENOG4108IUW ABC transporter B7P25_02785 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B7P25_02790 ENOG4105G5W regulator Fur family B7P25_02910 ENOG4108JQC penicillin-binding protein 1A B7P25_02915 ENOG4107ZQN disulfide bond B7P25_02925 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) B7P25_02935 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) B7P25_02940 ENOG4105BZU Histidine kinase B7P25_02950 ENOG4105CYN Serine protein kinase B7P25_02975 ENOG4105C94 Transporter B7P25_02990 ENOG4105DZ6 Band 7 protein B7P25_03000 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B7P25_03005 ENOG4108V9W transcriptional regulatory protein B7P25_03010 ENOG4105D4T Citrate transporter B7P25_03030 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B7P25_03035 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B7P25_03040 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B7P25_03045 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component B7P25_03050 ENOG4105BZ7 extracellular solute-binding protein family 1 B7P25_03055 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) B7P25_03060 ENOG4108STX response regulator B7P25_03065 ENOG4105US7 Histidine kinase B7P25_03090 ENOG4108MRH transcriptional regulatory protein B7P25_03100 ENOG4105C6K Malic enzyme B7P25_03110 ENOG4108UZ3 Transporter B7P25_03115 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7P25_03125 ENOG4105BZU Histidine kinase B7P25_03130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_03140 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B7P25_03145 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B7P25_03150 ENOG4108JB9 formate dehydrogenase B7P25_03185 ENOG4105C59 p-type ATPase B7P25_03190 ENOG4105DAP Nicotinate phosphoribosyltransferase B7P25_03225 ENOG41073R8 VanW family B7P25_03230 ENOG4108KGH TRANSCRIPTIONal B7P25_03235 ENOG4105D9N nucleoside B7P25_03240 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase B7P25_03245 ENOG4105C37 (CBS) domain B7P25_03250 ENOG4108IJ0 Aspartate ammonia-lyase B7P25_03255 ENOG4105DAA L-lactate B7P25_03270 ENOG4105DUX Transporter B7P25_03275 ENOG4108MES Periplasmic binding protein B7P25_03280 ENOG4105DQ5 transport system permease protein B7P25_03285 ENOG4108IHU transport system permease protein B7P25_03290 ENOG4105E0A ABC, transporter B7P25_03295 ENOG4105DMQ Methyltransferase B7P25_03305 ENOG4105EXW epimerase dehydratase B7P25_03310 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) B7P25_03320 ENOG4107T89 von Willebrand factor, type A B7P25_03325 ENOG4105GMT ATPase associated with various cellular activities aaa_5 B7P25_03330 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B7P25_03345 ENOG4105BZU Histidine kinase B7P25_03350 ENOG4105D5Q Arginine ornithine antiporter B7P25_03355 ENOG4107414 GntR family transcriptional regulator B7P25_03360 ENOG4105C5Y PTS System B7P25_03365 ENOG4105CG3 alpha amylase, catalytic region B7P25_03380 ENOG4105E1K spore germination protein B7P25_03390 ENOG4105CRN Aminoglycoside phosphotransferase B7P25_03395 ENOG4105BZG amino acid carrier protein B7P25_03400 ENOG4105CDA abc transporter atp-binding protein B7P25_03405 ENOG4105CT1 (ABC) transporter B7P25_03410 ENOG4105EAD ABC transporter B7P25_03415 ENOG4105DRP amino acid AbC transporter B7P25_03420 ENOG4108IQI permease B7P25_03445 ENOG4105D29 Helix-turn-helix type 11 domain protein B7P25_03450 ENOG4105NAE bifunctional deaminase-reductase domain protein B7P25_03455 ENOG4105BZU Histidine kinase B7P25_03470 ENOG4105CHH sulfate transporter B7P25_03475 ENOG41068KF Universal stress protein B7P25_03485 ENOG4105DEF Extracellular solute-binding protein, family 5 B7P25_03495 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B7P25_03500 ENOG4108JQ7 (ABC) transporter B7P25_03510 ENOG4105CXY transporter B7P25_03515 ENOG41067TZ transcriptional regulator, MarR family B7P25_03520 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7P25_03525 ENOG4105ETE Transcriptional regulator (LacI family B7P25_03530 ENOG4108RVA ribokinase B7P25_03540 ENOG4105C2J ABC transporter B7P25_03545 ENOG4105CNN ABC, transporter B7P25_03550 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator B7P25_03555 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) B7P25_03565 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B7P25_03620 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B7P25_03625 ENOG41069ER domain protein B7P25_03630 ENOG4105VZ8 Transcriptional regulator B7P25_03645 ENOG4105DUX Transporter B7P25_03665 ENOG4105C85 amino acid B7P25_03670 ENOG4105C7N Xanthine uracil vitamin C permease B7P25_03685 ENOG4105MA6 gCN5-related N-acetyltransferase B7P25_03710 ENOG4105BZ9 Cytochrome C oxidase, subunit I B7P25_03715 ENOG4105E2S oxidase) subunit II B7P25_03720 ENOG4108IQI permease B7P25_03735 ENOG4106CAD Protein of unknown function (DUF3311) B7P25_03740 ENOG4105E1V na solute symporter B7P25_03755 ENOG4108NHD germination protein B7P25_03765 ENOG4105CE1 Ferrous iron transport protein b B7P25_03770 ENOG4105CE1 Ferrous iron transport protein b B7P25_03775 ENOG4105CE1 Ferrous iron transport protein b B7P25_03780 ENOG4105CVA phosphate B7P25_03785 ENOG4105C8U phosphate abc transporter B7P25_03790 ENOG4105E2Z phosphate ABC transporter (Permease B7P25_03915 ENOG41080XQ Signal transduction protein with cbs domains B7P25_03940 ENOG4105ETU transcriptional activator (TenA B7P25_03950 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component B7P25_03960 ENOG4108VEU Thiamine monophosphate synthase B7P25_03965 ENOG41080HI glycine oxidase B7P25_03980 ENOG4105D06 uba thif-type nad fad binding protein B7P25_03985 ENOG4105DWF phosphomethylpyrimidine kinase B7P25_04040 ENOG4108INS Transcriptional regulator B7P25_04055 ENOG4105C7N Xanthine uracil vitamin C permease B7P25_04065 ENOG4108PXI ErfK YbiS YcfS YnhG B7P25_04100 ENOG4108B31 Spore germination protein B7P25_04120 ENOG4107Y03 Nitroreductase B7P25_04125 ENOG4105ED1 spovr family B7P25_04140 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase B7P25_04145 ENOG4105XTG Pfam:DUF156 B7P25_04150 ENOG4105VFE sira family B7P25_04155 ENOG4107TPS domain protein B7P25_04160 ENOG4105VFE sira family B7P25_04170 ENOG41085GJ domain protein B7P25_04180 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase B7P25_04185 ENOG41087NI Sulfite exporter TauE/SafE B7P25_04195 ENOG4108KGH TRANSCRIPTIONal B7P25_04220 ENOG4105EMD TRANSCRIPTIONal B7P25_04225 ENOG4105VCP PTS System B7P25_04230 ENOG4105VZJ PTS System B7P25_04250 ENOG41069ER domain protein B7P25_04255 ENOG4107RBB ABC transporter, permease B7P25_04260 ENOG4105C19 ABC transporter B7P25_04295 ENOG4105WEF catalase B7P25_04330 ENOG4107T5V SNARE associated Golgi B7P25_04365 ENOG4105CUB amino acid B7P25_04370 ENOG4107RWR Sodium hydrogen exchanger B7P25_04380 ENOG4106KNT transcriptional regulator B7P25_04420 ENOG4108YXU transcriptional regulator AsnC family B7P25_04430 ENOG4105KPY Small multidrug resistance protein B7P25_04435 ENOG4105KPY Small multidrug resistance protein B7P25_04460 ENOG4105NF4 modulator of drug activity B7P25_04470 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) B7P25_04475 ENOG4105E5W Transporter B7P25_04485 ENOG4107RKG DJ-1/PfpI family B7P25_04490 ENOG4105CH6 catalase B7P25_04500 ENOG4105D5Q Arginine ornithine antiporter B7P25_04505 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) B7P25_04515 ENOG4105C26 Dehydrogenase B7P25_04535 ENOG4105BZ1 (ABC) transporter B7P25_04540 ENOG4105BZ1 (ABC) transporter B7P25_04555 ENOG4105DRP amino acid AbC transporter B7P25_04560 ENOG4105CDA abc transporter atp-binding protein B7P25_04575 ENOG410839P B7P25_04610 ENOG4107FQX Alpha-acetolactate decarboxylase B7P25_04640 ENOG4105D4P Coproporphyrinogen iii oxidase B7P25_04650 ENOG4105CEY Amp-dependent synthetase and ligase B7P25_04665 ENOG4105CHH sulfate transporter B7P25_04675 ENOG4105CGU Enoyl-CoA hydratase B7P25_04690 ENOG4105DER m42 family B7P25_04710 ENOG4105CTU Proline racemase B7P25_04740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7P25_04750 ENOG4108JQ7 (ABC) transporter B7P25_04815 ENOG4108IBT Inherit from COG: transposase B7P25_04860 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) B7P25_04925 ENOG4105CSH Transporter B7P25_04935 ENOG4108MRH transcriptional regulatory protein B7P25_04975 ENOG4105CVR type I restriction-modification system B7P25_04985 ENOG4107SCJ type I restriction enzyme EcoKI subunit R B7P25_05015 ENOG4105CDU Replicative dna helicase B7P25_05045 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7P25_05105 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B7P25_05125 ENOG4105CMT Dihydroxyacetone kinase B7P25_05135 ENOG4105CMT Dihydroxyacetone kinase B7P25_05145 ENOG410847I Transcriptional regulator, BadM Rrf2 family B7P25_05170 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase B7P25_05285 ENOG4105WN5 stage II sporulation protein B7P25_05295 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7P25_05305 ENOG4108MJI response regulator B7P25_05310 ENOG4105BZU Histidine kinase B7P25_05315 ENOG4105BZU Histidine kinase B7P25_05340 ENOG4105K8R UPF0145 protein B7P25_05375 ENOG4107VRP DNA repair exonuclease B7P25_05380 ENOG4106D4I domain protein B7P25_05420 ENOG4108MUZ hydrolase B7P25_05440 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B7P25_05455 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B7P25_05470 ENOG4105EMN RNA polymerase sigma factor B7P25_05495 ENOG4105C57 major facilitator superfamily B7P25_05500 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7P25_05510 ENOG4105EEM helicase B7P25_05515 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B7P25_05540 ENOG4105K59 histidine triad (HIT) protein B7P25_05580 ENOG410905X membrane-flanked domain protein B7P25_05585 ENOG4105CKV Membrane B7P25_05615 ENOG410905X membrane-flanked domain protein B7P25_05620 ENOG4105CKV Membrane B7P25_05625 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation B7P25_05630 ENOG4105BZ4 penicillin-binding protein B7P25_05645 ENOG4105D7V transposase B7P25_05655 ENOG4105C1Q protoporphyrinogen oxidase B7P25_05690 ENOG4105ECB domain protein B7P25_05705 ENOG4108MK9 spermidine N(1)-acetyltransferase B7P25_05715 ENOG4105D29 Helix-turn-helix type 11 domain protein B7P25_05725 ENOG4106AXD B7P25_05730 ENOG4108RQ5 Beta-lactamase domain-containing protein B7P25_05735 ENOG4105DF9 Lipoate-protein, ligase B7P25_05750 ENOG4105CEY Amp-dependent synthetase and ligase B7P25_05790 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) B7P25_05795 ENOG4107RN3 metallophosphoesterase B7P25_05805 ENOG4107TVP HD domain protein B7P25_05815 ENOG4108AEY RNA polymerase sigma factor B7P25_05820 ENOG41086D8 Transcriptional regulator B7P25_05840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7P25_05865 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 B7P25_05870 ENOG4105C8Q Methyl-accepting chemotaxis B7P25_05885 ENOG4107QP3 malate synthase g B7P25_05900 ENOG4105VEQ Cold shock protein B7P25_05915 ENOG4105XVF Competence transcription factor B7P25_05930 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination B7P25_05935 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation B7P25_05980 ENOG4105ERH Fumarylacetoacetate hydrolase B7P25_06005 ENOG4105CAQ asparagine synthetase B7P25_06010 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B7P25_06015 ENOG4105CH6 catalase B7P25_06020 ENOG4105BZU Histidine kinase B7P25_06045 ENOG4105QNR S1 RNA binding domain protein B7P25_06050 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B7P25_06060 ENOG4107AYK membrAne B7P25_06065 ENOG41073B9 B7P25_06075 ENOG4108KP7 hydrolase B7P25_06090 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit B7P25_06120 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7P25_06125 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) B7P25_06145 ENOG4105C31 Tryptophanyl-tRNA synthetase B7P25_06165 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B7P25_06170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7P25_06180 ENOG4108JQ7 (ABC) transporter B7P25_06185 ENOG4105UQX Mate efflux family protein B7P25_06210 ENOG4108ZCF integral membrane protein B7P25_06220 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B7P25_06230 ENOG4105DPN Oligoendopeptidase f B7P25_06245 ENOG4108Z18 K06886 hemoglobin B7P25_06250 ENOG4105MIX Adenylate cyclase B7P25_06255 ENOG4106EFP UPF0738 protein B7P25_06265 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B7P25_06270 ENOG4105EMS pseudouridine synthase B7P25_06290 ENOG4105K64 Glycosyl transferase, family 2 B7P25_06310 ENOG4107TVC Glycosyl transferase, family 2 B7P25_06330 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) B7P25_06335 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase B7P25_06345 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase B7P25_06420 ENOG4105CK7 Sodium proline symporter B7P25_06430 ENOG4105CRQ synthase (Component I) B7P25_06435 ENOG4105DDQ anthranilate synthase B7P25_06530 ENOG4105C7S Dehydrogenase B7P25_06540 ENOG4105VZ8 Transcriptional regulator B7P25_06590 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7P25_06605 ENOG4108IUX (ABC) transporter B7P25_06610 ENOG4105RHA ABC transporter, permease B7P25_06620 ENOG4108C33 Resolvase B7P25_06670 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7P25_06685 ENOG41063R6 B7P25_06735 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7P25_06745 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) B7P25_06765 ENOG4105VFR signal peptidase B7P25_06800 ENOG4105C26 Dehydrogenase B7P25_06810 ENOG4105F38 ABC transporter, permease B7P25_06815 ENOG4105D38 putrescine abc transporter B7P25_06820 ENOG4107RUE extracellular solute-binding protein family 1 B7P25_06830 ENOG4105EYF MMPL domain protein B7P25_06840 ENOG4108YBP pseudouridine synthase B7P25_06850 ENOG4105K4I Scp-like extracellular B7P25_06855 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B7P25_06860 ENOG4105CQB FAD linked oxidase domain protein B7P25_06875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_06880 ENOG4105BZU Histidine kinase B7P25_06885 ENOG4105JXH GntR family transcriptional regulator B7P25_06905 ENOG4106A3R peptidase B7P25_06915 ENOG4108QTI )-transporter B7P25_06920 ENOG4107TS3 membrane protein, TerC B7P25_06925 ENOG4105CZN Potassium uptake protein B7P25_06930 ENOG410681C small acid-soluble spore protein B7P25_06935 ENOG4108Z7G MaoC domain protein dehydratase B7P25_06955 ENOG4105CHR reductase B7P25_06965 ENOG4105MWK D-amino acid dehydrogenase, small subunit B7P25_06990 ENOG4105C4Y ABC transporter B7P25_06995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B7P25_07000 ENOG4107RCV ABC transporter, permease B7P25_07020 ENOG4105E98 transcriptional regulator DeoR family B7P25_07035 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) B7P25_07045 ENOG4105PXI polysaccharide deacetylase B7P25_07055 ENOG4105BZU Histidine kinase B7P25_07060 ENOG41090MY MarR family Transcriptional regulator B7P25_07070 ENOG4106DF1 B7P25_07080 ENOG4105BZU Histidine kinase B7P25_07090 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase B7P25_07095 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) B7P25_07145 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B7P25_07150 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7P25_07160 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7P25_07165 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7P25_07170 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B7P25_07175 ENOG4105CZV ABC transporter B7P25_07185 ENOG4105CJ1 ABC, transporter B7P25_07225 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B7P25_07230 ENOG4105EA8 2-Nitropropane dioxygenase B7P25_07235 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B7P25_07245 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B7P25_07270 ENOG4105NQC Flavodoxin B7P25_07315 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B7P25_07345 ENOG4105CZN Potassium uptake protein B7P25_07350 ENOG41063Y9 B7P25_07355 ENOG4105KBJ sporulation protein ytfj B7P25_07385 ENOG4105CM2 brancheD-chain amino acid aminotransferase B7P25_07390 ENOG4105C7K acetolactate synthase B7P25_07395 ENOG4108ZP8 Acetolactate synthase small subunit B7P25_07400 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B7P25_07435 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) B7P25_07470 ENOG4107RVV histidinol phosphate phosphatase, hisj family B7P25_07485 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B7P25_07490 ENOG4105E0M Sulfatase B7P25_07500 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) B7P25_07520 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) B7P25_07525 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B7P25_07535 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B7P25_07540 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B7P25_07545 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B7P25_07555 ENOG4105C8J )-transporter B7P25_07575 ENOG4105DFD Na H antiporter B7P25_07595 ENOG4105ENE Histidine kinase B7P25_07600 ENOG4105WH1 Two component transcriptional regulator luxr family B7P25_07620 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) B7P25_07670 ENOG4105CJ3 phosphate transporter B7P25_07675 ENOG4107GRR phosphate transport regulator B7P25_07680 ENOG4105BZ4 penicillin-binding protein B7P25_07695 ENOG4105BZU Histidine kinase B7P25_07700 ENOG4105I3N Conserved Protein B7P25_07715 ENOG4105BZU Histidine kinase B7P25_07755 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B7P25_07760 ENOG4105DZ1 carboxypeptidase B7P25_07765 ENOG4108JIC nucleoside recognition domain protein B7P25_07775 ENOG4105FE9 pseudouridine synthase B7P25_07785 ENOG4107TWT Cytochrome c biogenesis protein B7P25_07790 ENOG4105CRE cytochrome C B7P25_07795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_07800 ENOG4105BZU Histidine kinase B7P25_07805 ENOG4108WBT adenosyltransferase B7P25_07810 ENOG41063SB peptidase B7P25_07820 ENOG4108SAX Membrane B7P25_07835 ENOG4105C9U ATP-dependent DNA helicase RecQ B7P25_07840 ENOG4105I7S Abortive infection protein B7P25_07850 ENOG4107RGJ metallophosphoesterase B7P25_07855 ENOG4107X2D transcriptional regulator, merr family B7P25_07860 ENOG4108S6Z Negative regulator of genetic competence B7P25_07885 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase B7P25_07890 ENOG4105HDK L-asparaginase B7P25_07925 ENOG4105S2F B7P25_07930 ENOG41065D1 B7P25_07960 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) B7P25_07975 ENOG4105XXQ heptaprenyl diphosphate synthase component I B7P25_07985 ENOG4105EAH synthase B7P25_08005 ENOG4105CIH Imidazole acetol-phosphate transaminase B7P25_08010 ENOG41068YB TPR repeat-containing protein B7P25_08025 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) B7P25_08030 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) B7P25_08035 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit B7P25_08070 ENOG4108JYZ YitT family B7P25_08075 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase B7P25_08090 ENOG4105FJR Lmbe family B7P25_08095 ENOG4105CPK Glycosyl transferase (Group 1 B7P25_08135 ENOG4105DVT helicase B7P25_08140 ENOG4105YAC B7P25_08160 ENOG4105CSM endonuclease III B7P25_08170 ENOG4105BZ4 penicillin-binding protein B7P25_08230 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) B7P25_08240 ENOG4105DVT helicase B7P25_08245 ENOG4105CTD carboxy-peptidase B7P25_08260 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B7P25_08270 ENOG4105C2W permease B7P25_08275 ENOG4105DHF Membrane B7P25_08285 ENOG410890F Dynamin family B7P25_08295 ENOG4108W0I acetyltransferase B7P25_08305 ENOG4105KHC sulfurtransferase B7P25_08340 ENOG4106032 Glutathionylspermidine synthase B7P25_08370 ENOG4108SZE gCN5-related N-acetyltransferase B7P25_08390 ENOG41081VK Ribonuclease B7P25_08455 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7P25_08470 ENOG4107RWR Sodium hydrogen exchanger B7P25_08475 ENOG4105CN5 Metallo-Beta-Lactamase B7P25_08480 ENOG4108Z5V transcriptional regulator, merr family B7P25_08490 ENOG4105H67 Protein of unknown function (DUF421) B7P25_08495 ENOG41080C8 DUF218 domain B7P25_08550 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B7P25_08560 ENOG4107R0U MotA TolQ exbB proton channel B7P25_08565 ENOG4105ER2 Ompa motb domain protein B7P25_08570 ENOG4107YTP response regulator receiver protein B7P25_08575 ENOG4105CBS Chea signal transduction histidine kinase B7P25_08580 ENOG4105DD5 Flagellar motor switch protein B7P25_08595 ENOG4105BZU Histidine kinase B7P25_08615 ENOG4105E1Q flagellar hook-associated protein B7P25_08625 ENOG410804A Flagellar hook-associated 2 domain-containing protein B7P25_08640 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) B7P25_08645 ENOG4108ZC9 flagellar basal-body rod protein flgc B7P25_08650 ENOG41075Z6 flagellar hook-basal body complex protein fliE B7P25_08655 ENOG4107U2N Flagellar M-ring protein B7P25_08660 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B7P25_08690 ENOG4105BZE flagellar hook protein, FlgE B7P25_08705 ENOG4107R88 Chemotaxis protein (CheV) B7P25_08740 ENOG4105I03 Flagellin B7P25_08745 ENOG4105E4C Lytic transglycosylase catalytic B7P25_08755 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B7P25_08760 ENOG4105DD5 Flagellar motor switch protein B7P25_08770 ENOG4105CN7 Flagellar biosynthetic protein FliP B7P25_08775 ENOG4105VS8 Flagellar biosynthetic protein fliq B7P25_08785 ENOG4105D00 flagellar biosynthetic protein flhB B7P25_08790 ENOG4105D7B Flagellar biosynthesis protein flha B7P25_08795 ENOG4105FZW flagellar biosynthesis regulator FlhF B7P25_08800 ENOG4105KTQ flagellar basal-body rod protein B7P25_08805 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B7P25_08840 ENOG4105KAC Antibiotic biosynthesis monooxygenase B7P25_08865 ENOG4105DUM transcriptional regulator, lysR family B7P25_08870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B7P25_08875 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein B7P25_08880 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component B7P25_08885 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) B7P25_08925 ENOG4105CVJ phosphoglycerate mutase B7P25_08940 ENOG4105K56 Transcriptional regulator B7P25_08950 ENOG4105CAQ asparagine synthetase B7P25_08970 ENOG4105PGM cation diffusion facilitator family transporter B7P25_08980 ENOG4105DRR Transcriptional regulator, GntR family B7P25_08985 ENOG4108UZ3 Transporter B7P25_08990 ENOG4105CKI cobalamin synthesis protein B7P25_09000 ENOG4108PJD permease B7P25_09015 ENOG4105DFD Na H antiporter B7P25_09020 ENOG4105VUF Transcriptional regulator B7P25_09030 ENOG4105C9Q fumarate hydratase class II B7P25_09050 ENOG4107QJQ Mate efflux family protein B7P25_09060 ENOG4105EC3 peptidase S51, dipeptidase E B7P25_09080 ENOG4107QIV Cytochrome c biogenesis protein B7P25_09110 ENOG4106BRA Membrane B7P25_09150 ENOG4105CJ1 ABC, transporter B7P25_09180 ENOG4108IBT Inherit from COG: transposase B7P25_09200 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) B7P25_09210 ENOG4108IJ0 Aspartate ammonia-lyase B7P25_09215 ENOG4105C6K Malic enzyme B7P25_09255 ENOG41067QW Transcriptional regulator B7P25_09285 ENOG4105FVX B7P25_09315 ENOG4105CSR polyphosphate kinase 2 B7P25_09325 ENOG4105DXI Major Facilitator superfamily B7P25_09340 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B7P25_09350 ENOG4105EU0 Major facilitator Superfamily B7P25_09355 ENOG4105C6T cysteine synthase B7P25_09375 ENOG4105C8J )-transporter B7P25_09385 ENOG4105X5K response regulator receiver protein B7P25_09390 ENOG4105H67 Protein of unknown function (DUF421) B7P25_09415 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) B7P25_09420 ENOG4105CHR reductase B7P25_09425 ENOG4105CM2 brancheD-chain amino acid aminotransferase B7P25_09430 ENOG4105C7K acetolactate synthase B7P25_09435 ENOG4108ZP8 Acetolactate synthase small subunit B7P25_09440 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B7P25_09450 ENOG4105C7B Threonine dehydratase B7P25_09475 ENOG4105C6X Major Facilitator B7P25_09480 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b B7P25_09490 ENOG4105DY9 regulatoR B7P25_09495 ENOG4105CYC Transferase B7P25_09515 ENOG4105F6J Alpha beta hydrolase fold B7P25_09555 ENOG41068WN B7P25_09560 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7P25_09580 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) B7P25_09585 ENOG4105C72 UPF0176 protein B7P25_09595 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) B7P25_09600 ENOG4105C0X amino acid B7P25_09630 ENOG4107RHR regulatoR B7P25_09640 ENOG4105D9N nucleoside B7P25_09645 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) B7P25_09680 ENOG4107RAQ aminopeptidase B7P25_09685 ENOG4107R16 Multicopper oxidase B7P25_09730 ENOG4108T5E Copper resistance protein B7P25_09735 ENOG4105KTB nuclear export factor GLE1 B7P25_09745 ENOG4107RT3 EamA-like transporter family B7P25_09750 ENOG4105GZI Transcriptional regulator B7P25_09755 ENOG4108Z40 Transcriptional regulator B7P25_09760 ENOG4107ZXU DSBA oxidoreductase B7P25_09765 ENOG4108TVJ Nitroreductase B7P25_09775 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B7P25_09780 ENOG4106F5Q Membrane B7P25_09805 ENOG4105C0Z ABC transporter B7P25_09810 ENOG4108IV0 ABC, transporter B7P25_09815 ENOG4105C32 Amino acid ABC transporter (Permease) B7P25_09825 ENOG4105SKE transcriptional Regulator LysR family B7P25_09855 ENOG4105C4M (Ubiquinol oxidase) subunit I B7P25_09860 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B7P25_09865 ENOG4108JJ9 ABC, transporter B7P25_09870 ENOG4108JJ8 (ABC) transporter B7P25_09880 ENOG4105K64 Glycosyl transferase, family 2 B7P25_09890 ENOG4108UT6 Transferase hexapeptide repeat containing protein B7P25_09945 ENOG4105BZ1 (ABC) transporter B7P25_09950 ENOG4105EFI regulatoR B7P25_09955 ENOG4105BZU Histidine kinase B7P25_09965 ENOG41075D4 Aminoglycoside 6-adenylyltransferase B7P25_09970 ENOG4108ZJ4 polysaccharide deacetylase B7P25_09990 ENOG4105D6E homoserine dehydrogenase B7P25_10000 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) B7P25_10030 ENOG4108KGH TRANSCRIPTIONal B7P25_10040 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7P25_10045 ENOG4105BZU Histidine kinase B7P25_10080 ENOG4108KGH TRANSCRIPTIONal B7P25_10090 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7P25_10095 ENOG4105BZU Histidine kinase B7P25_10100 ENOG4107VMI polysaccharide deacetylase B7P25_10110 ENOG4105KT7 mgtC SapB transporter B7P25_10115 ENOG4105VRR gCN5-related N-acetyltransferase B7P25_10125 ENOG4105DUU IucA IucC family protein B7P25_10130 ENOG4105CEY Amp-dependent synthetase and ligase B7P25_10145 ENOG4108WBH protein TIM barrel B7P25_10150 ENOG4105YWU small acid-soluble spore protein B7P25_10160 ENOG4108ZUB Lysine exporter protein (Lyse ygga) B7P25_10265 ENOG4105EFC phage portal protein HK97 family B7P25_10300 ENOG4105KRN Transcriptional regulator, abrb family B7P25_10310 ENOG4105YVS arsR family transcriptional regulator B7P25_10315 ENOG4107SET aldo keto reductase B7P25_10320 ENOG4107XZQ multidrug resistance protein B7P25_10345 ENOG4105C8Q Methyl-accepting chemotaxis B7P25_10365 ENOG4108K88 Membrane B7P25_10370 ENOG4108WPJ Ferritin-like domain B7P25_10385 ENOG4105DEN Luciferase family B7P25_10405 ENOG4107QM2 Aldo Keto reductase B7P25_10410 ENOG4105CKI cobalamin synthesis protein B7P25_10430 ENOG4105DSE periplasmic solute binding protein B7P25_10440 ENOG4105K4T epimerase B7P25_10450 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B7P25_10475 ENOG4105CVJ phosphoglycerate mutase B7P25_10495 ENOG4107T5V SNARE associated Golgi B7P25_10510 ENOG4108PJD permease B7P25_10520 ENOG4108S4H thioesterase Superfamily protein B7P25_10530 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B7P25_10550 ENOG4105SXS Protein of unknown function (DUF456) B7P25_10555 ENOG4105C37 (CBS) domain B7P25_10575 ENOG4108Z7R Chaperone CsaA B7P25_10595 ENOG4108ZRV stage ii sporulation protein p B7P25_10605 ENOG4108VXD carboxy-peptidase B7P25_10615 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B7P25_10635 ENOG4105EFA 4-hydroxyphenylacetate B7P25_10645 ENOG4105U1N riboflavin B7P25_10660 ENOG4105KME endoribonuclease L-psp B7P25_10690 ENOG41069HH 4-oxalocrotonate tautomerase B7P25_10700 ENOG4108X4Q Hydrolase B7P25_10710 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B7P25_10715 ENOG4107RBS Methyltransferase B7P25_10730 ENOG41087PP glycosyltransferase MGT family B7P25_10735 ENOG4108JYZ YitT family B7P25_10740 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7P25_10770 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B7P25_10795 ENOG4106PAW secretion accessory protein EsaA YueB B7P25_10805 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) B7P25_10810 ENOG4108MGT Required for secretion of EsxA and EsxB B7P25_10890 ENOG4105KBJ sporulation protein ytfj B7P25_10915 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B7P25_10940 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily B7P25_10950 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein B7P25_10955 ENOG4105EMN RNA polymerase sigma factor B7P25_10970 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) B7P25_10980 ENOG4105CNW domain protein B7P25_10990 ENOG4108V06 Glutathione peroxidase B7P25_11005 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B7P25_11025 ENOG4108IUE nitrate reductase beta subunit B7P25_11030 ENOG4105R3A Nitrate reductase B7P25_11040 ENOG4107V6Q Cyclic nucleotide-binding domain B7P25_11045 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7P25_11050 ENOG4105D06 uba thif-type nad fad binding protein B7P25_11055 ENOG4105CVM Molybdenum cofactor synthesis domain protein B7P25_11060 ENOG4108ZAF Molybdopterin B7P25_11090 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B7P25_11095 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B7P25_11100 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B7P25_11105 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit B7P25_11110 ENOG4108IFG nitrite reductase, (NAD(P)H) B7P25_11115 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) B7P25_11140 ENOG4105MCT stage V sporulation protein S B7P25_11165 ENOG4105C5H ABC transporter B7P25_11210 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) B7P25_11215 ENOG4105C4R Atp-dependent dna helicase B7P25_11230 ENOG4108KF3 Electron transport protein SCO1 SenC B7P25_11235 ENOG4107ZQN disulfide bond B7P25_11255 ENOG41085FC arsR family transcriptional regulator B7P25_11270 ENOG4105H3G oxidoreductase B7P25_11285 ENOG41082YX Transcriptional regulator, arsr family B7P25_11290 ENOG4105D6J arsenicaL-resistance protein B7P25_11330 ENOG4108UUM single-stranded DNA-binding protein B7P25_11350 ENOG4107YX5 Pfam:DUF548 B7P25_11355 ENOG4105C75 arginyL-tRNA synthetase B7P25_11415 ENOG4105C5S asparaginyl-tRNA synthetase B7P25_11420 ENOG4105BZW Glycerate kinase B7P25_11425 ENOG4107QPK )-transporter B7P25_11430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_11435 ENOG41062D9 Histidine kinase B7P25_11450 ENOG4105C8J )-transporter B7P25_11470 ENOG4107XGZ Hydrolase B7P25_11475 ENOG4105CY2 Citrate transporter B7P25_11480 ENOG4105C0A alcohol dehydrogenase B7P25_11495 ENOG4105KD7 acetyltransferase B7P25_11500 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase B7P25_11525 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 B7P25_11545 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) B7P25_11560 ENOG4107RVG penicillin-binding protein B7P25_11570 ENOG4105E9Q Acyl-transferase B7P25_11575 ENOG4108UT2 hemolysin iii B7P25_11585 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B7P25_11600 ENOG4108RCR degv family B7P25_11605 ENOG4105E8R UPF0173 metal-dependent hydrolase B7P25_11610 ENOG4108KF3 Electron transport protein SCO1 SenC B7P25_11615 ENOG4107Y70 Heat shock protein B7P25_11620 ENOG4105CAQ asparagine synthetase B7P25_11640 ENOG4108MES Periplasmic binding protein B7P25_11645 ENOG4105F0I Aminotransferase B7P25_11680 ENOG4105D8X mechanosensitive ion channel B7P25_11685 ENOG4105BZU Histidine kinase B7P25_11690 ENOG4105WH1 Two component transcriptional regulator luxr family B7P25_11700 ENOG4106KNT transcriptional regulator B7P25_11730 ENOG4105CMG Carbohydrate kinase B7P25_11735 ENOG4105CMG Carbohydrate kinase B7P25_11765 ENOG4108IJ8 ABC transporter B7P25_11770 ENOG4105E90 ABC transporter B7P25_11835 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7P25_11850 ENOG4107S4Y M20 DapE family protein YgeY B7P25_11855 ENOG4108TSC N-acetyltransferase B7P25_11860 ENOG4108JUB Transcriptional regulator B7P25_11870 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B7P25_11910 ENOG4108N23 SpoOM-related protein B7P25_11915 ENOG410841Q phosphoesterase PA-phosphatase related protein B7P25_11925 ENOG4105SZ6 Thioredoxin B7P25_12000 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B7P25_12040 ENOG4105BZ4 penicillin-binding protein B7P25_12045 ENOG4105CZM Major Facilitator B7P25_12050 ENOG4105W8X HesB YadR YfhF-family protein B7P25_12060 ENOG4105DXD 2-methylcitrate dehydratase B7P25_12065 ENOG4105CR4 methylisocitrate lyase B7P25_12070 ENOG4105C1G acyl-Coa dehydrogenase B7P25_12075 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B7P25_12085 ENOG4105N14 lysine exporter protein LysE YggA B7P25_12090 ENOG4105E39 Enoyl-CoA hydratase B7P25_12105 ENOG4107RFY SbcCD D subunit B7P25_12110 ENOG4105EYH Exonuclease B7P25_12145 ENOG4105FCD Major Facilitator B7P25_12155 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase B7P25_12160 ENOG4105E4F Isochorismate synthase B7P25_12165 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase B7P25_12170 ENOG4105WQI isochorismatase B7P25_12175 ENOG4105CEY Amp-dependent synthetase and ligase B7P25_12180 ENOG4105WQT MbtH domain protein B7P25_12185 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7P25_12200 ENOG4105K70 DNA-binding protein B7P25_12220 ENOG4105BZG amino acid carrier protein B7P25_12240 ENOG4105FE9 pseudouridine synthase B7P25_12245 ENOG4105C22 threonyL-tRNA synthetase B7P25_12250 ENOG4105C19 ABC transporter B7P25_12265 ENOG4107SKW Inherit from COG: Alpha beta hydrolase B7P25_12290 ENOG4108D32 Methyltransferase B7P25_12310 ENOG41081I9 integral membrane protein B7P25_12325 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) B7P25_12335 ENOG4105EYF MMPL domain protein B7P25_12360 ENOG4105WCN acetyltransferase B7P25_12390 ENOG4105C1Q protoporphyrinogen oxidase B7P25_12400 ENOG41068WN B7P25_12410 ENOG4105VEQ Cold shock protein B7P25_12430 ENOG410667J hydrolase B7P25_12480 ENOG4107V2S Transcriptional regulator B7P25_12485 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B7P25_12500 ENOG4105DND Transcriptional regulator B7P25_12505 ENOG4108RPX mosc domain containing protein B7P25_12520 ENOG4105BZ1 (ABC) transporter B7P25_12525 ENOG4105BZ1 (ABC) transporter B7P25_12545 ENOG4108JCI Transcriptional regulator B7P25_12575 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B7P25_12590 ENOG4108KPJ rna polymerase sigma factor B7P25_12620 ENOG4105F32 YngK protein B7P25_12650 ENOG4105RD7 BadF BadG BcrA BcrD B7P25_12660 ENOG4107STF Involved in phosphonate degradation (By similarity) B7P25_12715 ENOG4105C1J atp-dependent rna helicase B7P25_12730 ENOG4108RZE Tetr family transcriptional regulator B7P25_12750 ENOG41088CC tellurite resistance protein tehB B7P25_12765 ENOG4107RA9 decarboxylase B7P25_12770 ENOG41090HR transcriptional regulator B7P25_12800 ENOG4105CIN aminoacyl-histidine dipeptidase B7P25_12820 ENOG4107RVG penicillin-binding protein B7P25_12825 ENOG4105EMN RNA polymerase sigma factor B7P25_12835 ENOG4107RF6 penicillin-binding protein B7P25_12840 ENOG4107RF6 penicillin-binding protein B7P25_12860 ENOG4105DIN metallophosphoesterase B7P25_12880 ENOG4107Z3H Transcriptional regulator, TetR family B7P25_12900 ENOG4105C1G acyl-Coa dehydrogenase B7P25_12905 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B7P25_12910 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit B7P25_12915 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase B7P25_12920 ENOG4105E39 Enoyl-CoA hydratase B7P25_12925 ENOG4107QX3 carboxylase B7P25_12930 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B7P25_12945 ENOG4105DBI uridine monophosphokinase B7P25_12960 ENOG4105DZ1 carboxypeptidase B7P25_12975 ENOG4105T9C HD domain B7P25_12985 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B7P25_13025 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B7P25_13040 ENOG4105FQP Beta-lactamase B7P25_13050 ENOG4107Y80 Major Facilitator superfamily B7P25_13070 ENOG4105CUV Homoserine Kinase B7P25_13110 ENOG410900G Protein of unknown function (DUF421) B7P25_13135 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B7P25_13145 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein B7P25_13155 ENOG4105DK7 lysyl-tRNA synthetase B7P25_13240 ENOG4105ETU transcriptional activator (TenA B7P25_13330 ENOG410667J hydrolase B7P25_13340 ENOG4105BZU Histidine kinase B7P25_13345 ENOG4107RF6 penicillin-binding protein B7P25_13380 ENOG4108HGU Histidine kinase B7P25_13390 ENOG4105RHY Pfam:UPF0157 B7P25_13395 ENOG4105CB2 alcohol dehydrogenase B7P25_13400 ENOG4105CJN penicillin-binding protein B7P25_13410 ENOG4105FQP Beta-lactamase B7P25_13445 ENOG4108V4B ThiJ pfpI B7P25_13485 ENOG4107Y80 Major Facilitator superfamily B7P25_13505 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B7P25_13525 ENOG4107Y9U Membrane B7P25_13570 ENOG4105FCD Major Facilitator B7P25_13585 ENOG4105E09 nadh pyrophosphatase B7P25_13590 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B7P25_13595 ENOG4108Z4K mutator MutT protein B7P25_13630 ENOG4108XI2 Domain of unknown function (DUF1963) B7P25_13650 ENOG4108NRW Phospholipase, patatin family B7P25_13655 ENOG4105KWG Pfam:DUF1696 B7P25_13690 ENOG4105PKS Excinuclease abc c subunit domain protein B7P25_13735 ENOG4107VFR oxidoreductase B7P25_13760 ENOG4105U0R haloacid dehalogenase-like hydrolase B7P25_13785 ENOG4108IUM Glycogen debranching enzyme B7P25_13810 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B7P25_13820 ENOG4105FDR Membrane B7P25_13875 ENOG4105MSI germination protein ypeb B7P25_13900 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) B7P25_13910 ENOG4107Z3H Transcriptional regulator, TetR family B7P25_13945 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family B7P25_13965 ENOG4105E98 transcriptional regulator DeoR family B7P25_13985 ENOG41062ES Transcriptional regulator B7P25_14005 ENOG4107QKR Dehydrogenase B7P25_14100 ENOG4105E66 phosphoriboisomerase A B7P25_14105 ENOG41082BV acetyltransferase B7P25_14110 ENOG4108M1A Chitin-binding protein B7P25_14115 ENOG41087PP glycosyltransferase MGT family B7P25_14140 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B7P25_14180 ENOG4108Z7F N-acetyltransferase B7P25_14200 ENOG4105EEM helicase B7P25_14220 ENOG4105C9U ATP-dependent DNA helicase RecQ B7P25_14280 ENOG4108M1A Chitin-binding protein B7P25_14300 ENOG4105BZG amino acid carrier protein B7P25_14305 ENOG4105C26 Dehydrogenase B7P25_14310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B7P25_14315 ENOG4105CTU Proline racemase B7P25_14320 ENOG4105CTU Proline racemase B7P25_14325 ENOG41080HI glycine oxidase B7P25_14335 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein B7P25_14365 ENOG4107T5V SNARE associated Golgi B7P25_14380 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B7P25_14385 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) B7P25_14400 ENOG4105DTQ mandelate racemase muconate lactonizing B7P25_14450 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) B7P25_14455 ENOG4105BZU Histidine kinase B7P25_14460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_14490 ENOG4105DPN Oligoendopeptidase f B7P25_14505 ENOG4105EPR degv family B7P25_14565 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) B7P25_14570 ENOG4106K7D Major facilitator family transporter B7P25_14590 ENOG4107BMA Transglycosylase associated protein B7P25_14605 ENOG41089UC methyltransferase, type 11 B7P25_14650 ENOG4105CHM Aminotransferase B7P25_14665 ENOG4108ZMI UPF0477 protein B7P25_14710 ENOG4105C02 permease B7P25_14725 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) B7P25_14730 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component B7P25_14735 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein B7P25_14760 ENOG4105E09 nadh pyrophosphatase B7P25_14780 ENOG4108AQF aminoglycoside N(3)-acetyltransferase B7P25_14835 ENOG4107VC0 DNA alkylation repair enzyme B7P25_14850 ENOG4107VMI polysaccharide deacetylase B7P25_14875 ENOG4108ZCF integral membrane protein B7P25_14880 ENOG4105E0M Sulfatase B7P25_14890 ENOG4105C5H ABC transporter B7P25_14900 ENOG4105EYF MMPL domain protein B7P25_14905 ENOG41082JN Transcriptional regulator B7P25_14925 ENOG4105CIH Imidazole acetol-phosphate transaminase B7P25_14940 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B7P25_14985 ENOG41069ER domain protein B7P25_15000 ENOG4105EMN RNA polymerase sigma factor B7P25_15025 ENOG4105D4B ABC, transporter B7P25_15035 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane B7P25_15045 ENOG4105DKT Transcriptional regulator B7P25_15050 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) B7P25_15060 ENOG41061GT Aldolase B7P25_15085 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) B7P25_15120 ENOG4105II7 pyrroline-5-carboxylate reductase B7P25_15130 ENOG4107258 Transcriptional regulator B7P25_15145 ENOG4105E0Y RtcB Protein B7P25_15155 ENOG4105ECK Fatty Acid Desaturase B7P25_15160 ENOG4105G6Z alkaline phosphatase B7P25_15170 ENOG4105VMP Transcriptional regulator B7P25_15185 ENOG41090T1 Membrane B7P25_15195 ENOG4108WCX response regulator B7P25_15205 ENOG4105KNA -acetyltransferase B7P25_15230 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B7P25_15255 ENOG4105CKK Glycosyl transferase, family 2 B7P25_15275 ENOG4105CKK Glycosyl transferase, family 2 B7P25_15285 ENOG4105C8Y Acetylornithine aminotransferase B7P25_15335 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B7P25_15430 ENOG4108IBT Inherit from COG: transposase B7P25_15450 ENOG4108TVJ Nitroreductase B7P25_15455 ENOG4105FS7 Transcriptional regulator B7P25_15480 ENOG4105WEC Molybdate metabolism regulator B7P25_15490 ENOG4105CMR udp-glucose 4-epimerase B7P25_15495 ENOG4105C19 ABC transporter B7P25_15525 ENOG4108XET gCN5-related N-acetyltransferase B7P25_15590 ENOG410635A Membrane B7P25_15600 ENOG4108IQI permease B7P25_15610 ENOG4105F1N DNA alkylation repair B7P25_15650 ENOG4107RF6 penicillin-binding protein B7P25_15690 ENOG4105P4J Allophanate hydrolase, subunit 1 B7P25_15695 ENOG4107258 Transcriptional regulator B7P25_15705 ENOG4106N3A copper homeostasis protein cutc B7P25_15715 ENOG4108ZRV stage ii sporulation protein p B7P25_15720 ENOG4108ZHR arsR family transcriptional regulator B7P25_15730 ENOG4105FDT acyl-CoA dehydrogenase B7P25_15745 ENOG4105DWD nucleoside recognition domain protein B7P25_15775 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B7P25_15850 ENOG4105E2A Dehydrogenase B7P25_15860 ENOG4108IJ0 Aspartate ammonia-lyase B7P25_15865 ENOG4105HDK L-asparaginase B7P25_15870 ENOG4108IMY Transcriptional regulator B7P25_15880 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) B7P25_15885 ENOG4105CUB amino acid B7P25_15955 ENOG4105CGH 5'-nucleotidase B7P25_15960 ENOG4105CH6 catalase B7P25_15970 ENOG4105CHJ isochorismatase hydrolase B7P25_16000 ENOG41090MY MarR family Transcriptional regulator B7P25_16040 ENOG4108606 TspO/MBR family B7P25_16045 ENOG4105CVP deoxyribo-dipyrimidine photolyase B7P25_16060 ENOG4108TWJ NADH dehydrogenase subunit 5 B7P25_16065 ENOG4105GPN Uncharacterized conserved protein (DUF2294) B7P25_16080 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B7P25_16090 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B7P25_16130 ENOG4105D6J arsenicaL-resistance protein B7P25_16135 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase B7P25_16140 ENOG41085FC arsR family transcriptional regulator B7P25_16165 ENOG4105BZU Histidine kinase B7P25_16170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_16185 ENOG4107P5I polyketide synthase B7P25_16190 ENOG4108IG5 Transcriptional regulator B7P25_16195 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B7P25_16200 ENOG4108YXU transcriptional regulator AsnC family B7P25_16270 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B7P25_16275 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7P25_16290 ENOG4105IIP Membrane B7P25_16305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_16310 ENOG41062D9 Histidine kinase B7P25_16345 ENOG4105K6H D-cysteine desulfhydrase B7P25_16375 ENOG4108NNI Beta-lactamase domain-containing protein B7P25_16380 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase B7P25_16390 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7P25_16405 ENOG4105C88 aminopeptidase B7P25_16420 ENOG4105W1Y Transcriptional regulator B7P25_16425 ENOG4105JQZ Methyltransferase B7P25_16445 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) B7P25_16465 ENOG4105BZU Histidine kinase B7P25_16475 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B7P25_16495 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B7P25_16515 ENOG4108JQ1 Dehydrogenase B7P25_16535 ENOG4108AEY RNA polymerase sigma factor B7P25_16550 ENOG41082W1 Cupin 2, conserved barrel domain protein B7P25_16560 ENOG410874W AraC family transcriptional regulator B7P25_16595 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B7P25_16760 ENOG4106YAD MORN repeat variant B7P25_16840 ENOG4108ISG Major Facilitator B7P25_16850 ENOG4107MII Sugar-specific transcriptional regulator TrmB B7P25_16855 ENOG4105CZM Major Facilitator B7P25_16875 ENOG4105DA5 (ABC) transporter B7P25_16880 ENOG41069JR B7P25_16890 ENOG4105RXJ B7P25_16895 ENOG4105KPY Small multidrug resistance protein B7P25_16900 ENOG4105KBX Transcriptional regulator, TetR family B7P25_16915 ENOG4105CRW Short chain fatty acid transporter B7P25_16925 ENOG4105DYS nad(p)h dehydrogenase (quinone) B7P25_16955 ENOG4108JJB ABC transporter B7P25_16960 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) B7P25_17010 ENOG41067QW Transcriptional regulator B7P25_17020 ENOG4108Z66 YbaK ebsC protein B7P25_17040 ENOG4105KVH Transcriptional regulator B7P25_17045 ENOG4108RCM Nitroreductase B7P25_17070 ENOG4108PSK reductase B7P25_17080 ENOG4105CJ1 ABC, transporter B7P25_17140 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase B7P25_17145 ENOG4105DKQ ROK family B7P25_17150 ENOG4106UW1 Major Facilitator superfamily B7P25_17155 ENOG4108UW5 maltose o-acetyltransferase B7P25_17160 ENOG4105C31 Tryptophanyl-tRNA synthetase B7P25_17190 ENOG4105DMQ Methyltransferase B7P25_17200 ENOG4105EV4 Multidrug resistance protein mdtH B7P25_17230 ENOG4105C37 (CBS) domain B7P25_17245 ENOG4105DDN Pentapeptide repeat-containing protein B7P25_17250 ENOG4105XDF Protein of unknown function (DUF1272) B7P25_17255 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) B7P25_17260 ENOG4105CMG Carbohydrate kinase B7P25_17265 ENOG4105C6Z Gluconate B7P25_17270 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) B7P25_17285 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase B7P25_17290 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase B7P25_17295 ENOG4105CIS alcohol dehydrogenase B7P25_17300 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone B7P25_17320 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B7P25_17325 ENOG4105D4Y metalloprotease B7P25_17335 ENOG4105C8Q Methyl-accepting chemotaxis B7P25_17340 ENOG4108UX3 '-nucleotidase B7P25_17350 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) B7P25_17355 ENOG4105KVH Transcriptional regulator B7P25_17370 ENOG4105CV8 reductase B7P25_17375 ENOG4105F27 Major Facilitator B7P25_17390 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) B7P25_17395 ENOG4105C44 Serine transporter B7P25_17430 ENOG4105KVH Transcriptional regulator B7P25_17435 ENOG4108TZY GntR Family Transcriptional Regulator B7P25_17440 ENOG4105D9R oxidoreductase B7P25_17445 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase B7P25_17450 ENOG4105KVH Transcriptional regulator B7P25_17455 ENOG4105KVH Transcriptional regulator B7P25_17490 ENOG4105JAB phenazine biosynthesis protein, phzf family B7P25_17500 ENOG4105CHR reductase B7P25_17515 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B7P25_17520 ENOG4105KVH Transcriptional regulator B7P25_17530 ENOG4108ZJ4 polysaccharide deacetylase B7P25_17580 ENOG4105KAF membrAne B7P25_17610 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) B7P25_17630 ENOG4107YXZ hydrolase, family 25 B7P25_17665 ENOG4105H3G oxidoreductase B7P25_17700 ENOG4105CIS alcohol dehydrogenase B7P25_17740 ENOG4108TN2 lmbE family B7P25_17750 ENOG4107R3E Citrate transporter B7P25_17765 ENOG4108MES Periplasmic binding protein B7P25_17770 ENOG4105EHG Permease protein B7P25_17775 ENOG4105DQ5 transport system permease protein B7P25_17780 ENOG4105NX3 Membrane B7P25_17785 ENOG4107ZY0 Phenazine biosynthesis-like protein B7P25_17805 ENOG4107V2S Transcriptional regulator B7P25_17825 ENOG4105C98 muts2 protein B7P25_17835 ENOG4105E5K Alpha-amylase B7P25_17840 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B7P25_17845 ENOG4105DPN Oligoendopeptidase f B7P25_17850 ENOG4108A04 Beta-lactamase B7P25_17880 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B7P25_17890 ENOG4105EEM helicase B7P25_17905 ENOG41082BM Transcriptional regulator, arsr family B7P25_17910 ENOG4105CIS alcohol dehydrogenase B7P25_17930 ENOG4105RHY Pfam:UPF0157 B7P25_17940 ENOG4105C09 Bile acid B7P25_17945 ENOG4105CQB FAD linked oxidase domain protein B7P25_17975 ENOG4108UT6 Transferase hexapeptide repeat containing protein B7P25_17985 ENOG4105K64 Glycosyl transferase, family 2 B7P25_17990 ENOG4105E39 Enoyl-CoA hydratase B7P25_18000 ENOG4105KT7 mgtC SapB transporter B7P25_18015 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B7P25_18020 ENOG41073R8 VanW family B7P25_18030 ENOG4108R1P B7P25_18050 ENOG4105VEQ Cold shock protein B7P25_18070 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B7P25_18105 ENOG4105DR5 peptidase B7P25_18110 ENOG41065S2 pneumococcal vaccine antigen B7P25_18115 ENOG4107YXZ hydrolase, family 25 B7P25_18160 ENOG410904N short-chain dehydrogenase reductase B7P25_18170 ENOG4106IQC argininosuccinate lyase B7P25_18185 ENOG4108IA2 Sodium pantothenate symporter B7P25_18195 ENOG4105C26 Dehydrogenase B7P25_18200 ENOG4105CHR reductase B7P25_18210 ENOG4105EWU Squalene--hopene cyclase B7P25_18220 ENOG4105FR1 rard protein B7P25_18225 ENOG410696E Membrane B7P25_18240 ENOG4105D1F ATP-binding protein B7P25_18250 ENOG4108ZAF Molybdopterin B7P25_18255 ENOG4105CVM Molybdenum cofactor synthesis domain protein B7P25_18260 ENOG4105D06 uba thif-type nad fad binding protein B7P25_18265 ENOG4105TMB Formate nitrite transporter B7P25_18280 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B7P25_18285 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) B7P25_18295 ENOG4108JB9 formate dehydrogenase B7P25_18305 ENOG4105E1K spore germination protein B7P25_18365 ENOG4107QJT sodium dicarboxylate symporter B7P25_18370 ENOG4108KGH TRANSCRIPTIONal B7P25_18380 ENOG4105EMN RNA polymerase sigma factor B7P25_18390 ENOG4105CIG ABC transporter B7P25_18400 ENOG4105D9R oxidoreductase B7P25_18410 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7P25_18420 ENOG4105K4P CoA-binding domain protein B7P25_18425 ENOG4105C0H protease B7P25_18430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_18440 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase B7P25_18445 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) B7P25_18450 ENOG4105W8X HesB YadR YfhF-family protein B7P25_18480 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B7P25_18490 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B7P25_18500 ENOG4108JJA ABC, transporter B7P25_18505 ENOG4108I0Z Aconitate hydratase B7P25_18535 ENOG4105E5W Transporter B7P25_18545 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B7P25_18565 ENOG4107F3J Amp-dependent synthetase and ligase B7P25_18570 ENOG4107ZYJ bioY protein B7P25_18575 ENOG4105CEY Amp-dependent synthetase and ligase B7P25_18590 ENOG4108IMY Transcriptional regulator B7P25_18640 ENOG4107AYK membrAne B7P25_18655 ENOG4105BZU Histidine kinase B7P25_18660 ENOG4105FBA Phospholipase Carboxylesterase B7P25_18665 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase B7P25_18670 ENOG4105CK7 Sodium proline symporter B7P25_18675 ENOG4105CBC glutamate synthase B7P25_18680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B7P25_18685 ENOG4108VJ1 Transcriptional regulator (CarD family B7P25_18690 ENOG4108903 Formimidoylglutamase B7P25_18715 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) B7P25_18760 ENOG4107QIV Cytochrome c biogenesis protein B7P25_18775 ENOG4105CH2 amidohydrolase B7P25_18785 ENOG4105CJ1 ABC, transporter B7P25_18795 ENOG4107RSM transcriptional regulator B7P25_18805 ENOG41067MG lrgb family B7P25_18845 ENOG4105BZ1 (ABC) transporter B7P25_18850 ENOG4105BZ1 (ABC) transporter B7P25_18875 ENOG4105D7V transposase B7P25_18895 ENOG4105D5T phosphonate abc transporter B7P25_18905 ENOG4105CGH 5'-nucleotidase B7P25_18915 ENOG4108SVB resolvase B7P25_18935 ENOG4105K7K Transcriptional regulator B7P25_18940 ENOG4105BZ1 (ABC) transporter B7P25_18965 ENOG4105CAQ asparagine synthetase B7P25_18970 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7P25_18980 ENOG4105D3Q Sugar transferase B7P25_19010 ENOG4105CGN Glycosyl transferase (Group 1 B7P25_19025 ENOG4105X1N Glycosyl transferase family 8 B7P25_19035 ENOG41068W6 Capsular polysaccharide biosynthesis protein B7P25_19040 ENOG4107SJB teichoic acid biosynthesis B7P25_19045 ENOG4108KMV Glycosyl transferase (Group 1 B7P25_19050 ENOG4108PQP glycosyl transferase group 1 B7P25_19060 ENOG4107YJ4 chain length determinant protein B7P25_19065 ENOG4105HTX biosynthesis protein B7P25_19070 ENOG4105C5F glutamine synthetase B7P25_19075 ENOG4105KV4 Transcriptional regulator B7P25_19080 ENOG4105CXI aluminum resistance protein B7P25_19085 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B7P25_19090 ENOG4105EN6 Membrane B7P25_19095 ENOG4106F1P AAA ATPase, central domain protein B7P25_19125 ENOG41069ER domain protein B7P25_19130 ENOG4105DM4 PTS System B7P25_19135 ENOG4105DE4 1-phosphofructokinase B7P25_19140 ENOG4105E98 transcriptional regulator DeoR family B7P25_19145 ENOG4107QW4 alcohol dehydrogenase B7P25_19150 ENOG4108SJC Membrane B7P25_19165 ENOG4105C85 amino acid B7P25_19195 ENOG4105TMB Formate nitrite transporter B7P25_19200 ENOG4105K70 DNA-binding protein B7P25_19210 ENOG4105C59 p-type ATPase B7P25_19215 ENOG410681U heavy metal transport detoxification protein B7P25_19220 ENOG4105VPX protein, conserved in bacteria B7P25_19230 ENOG4105NIV Esterase B7P25_19235 ENOG4105E0A ABC, transporter B7P25_19255 ENOG4105CGK Exodeoxyribonuclease III B7P25_19265 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B7P25_19270 ENOG4105D03 DNA-3-methyladenine glycosylase II B7P25_19300 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B7P25_19305 ENOG4105BZU Histidine kinase B7P25_19325 ENOG41067MG lrgb family B7P25_19340 ENOG4107TTQ Alpha beta hydrolase fold B7P25_19345 ENOG4107YEI lmbE family B7P25_19370 ENOG4105F0V Cell wall hydrolase B7P25_19375 ENOG4107R6R udp-galactopyranose mutase B7P25_19385 ENOG4105E0M Sulfatase B7P25_19390 ENOG410890F Dynamin family B7P25_19400 ENOG4107QHE Choloylglycine hydrolase B7P25_19425 ENOG4105DA5 (ABC) transporter B7P25_19455 ENOG4105DQU oxidoreductase, subunit beta B7P25_19465 ENOG4108IGT Dipeptidase B7P25_19470 ENOG4105MCT stage V sporulation protein S B7P25_19475 ENOG4105D48 metallophosphoesterase B7P25_19500 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase B7P25_19515 ENOG4105XZV Protein of unknown function (DUF3243) B7P25_19520 ENOG4108RKS Short-chain dehydrogenase reductase Sdr B7P25_19540 ENOG4105UIB (ABC) transporter B7P25_19545 ENOG4108JQ9 ABC transporter B7P25_19550 ENOG4105DIH basic membrane B7P25_19555 ENOG4105FDP GntR family transcriptional regulator B7P25_19560 ENOG4107QZI cell division protein FtsK B7P25_19570 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit B7P25_19585 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B7P25_19595 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B7P25_19600 ENOG4108S0H Dipicolinic acid synthetase, b subunit B7P25_19615 ENOG4105XSJ toxin secretion phage lysis holin B7P25_19680 ENOG4105CDU Replicative dna helicase B7P25_19715 ENOG4108IMY Transcriptional regulator B7P25_19745 ENOG4108S0H Dipicolinic acid synthetase, b subunit B7P25_19750 ENOG4105E35 Dipicolinate synthase subunit A B7P25_19765 ENOG4105C1V Peptidase, M16 B7P25_19785 ENOG4105DTN riboflavin biosynthesis protein ribF B7P25_19790 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) B7P25_19800 ENOG4105W7A Protein of unknown function (DUF503) B7P25_19810 ENOG4105VHM ribosomal protein B7P25_19815 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination B7P25_19820 ENOG4105CHV Transcription elongation factor NusA B7P25_19830 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B7P25_19845 ENOG4105DZP Membrane-associated zinc metalloprotease B7P25_19850 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) B7P25_19855 ENOG4105KNE Phosphatidate cytidylyltransferase B7P25_19900 ENOG4108HE4 integrase family B7P25_19910 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B7P25_19915 ENOG4105C79 DNA protecting protein DprA B7P25_19920 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha B7P25_19935 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) B7P25_19960 ENOG4105VB6 UPF0109 protein B7P25_19980 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) B7P25_19985 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) B7P25_20000 ENOG4105CHR reductase B7P25_20005 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase B7P25_20020 ENOG4105CB5 ATP-dependent DNA helicase recG B7P25_20025 ENOG4105DP4 dak2 domain fusion protein ylov B7P25_20030 ENOG4108ZAA Alkaline-shock protein B7P25_20045 ENOG4105FJ0 thiamine B7P25_20050 ENOG4105DJV ribulose-phosphate 3-epimerase B7P25_20055 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) B7P25_20060 ENOG4105D9P serine threonine protein kinase B7P25_20065 ENOG4108ZF3 Phosphatase B7P25_20075 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B B7P25_20085 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B7P25_20090 ENOG4105C25 Primosomal protein n' B7P25_20095 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase B7P25_20115 ENOG4105DSJ YicC domain protein B7P25_20125 ENOG4105F23 Fibronectin-binding protein B7P25_20130 ENOG4105DC7 peptidase M24 B7P25_20185 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B7P25_20215 ENOG4105C34 Pseudouridine synthase B7P25_20240 ENOG4105DBK s4 domain protein B7P25_20245 ENOG41067XK integral membrane protein B7P25_20255 ENOG4105DFA alanine racemase domain protein B7P25_20260 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase B7P25_20265 ENOG4105WR5 sporulation protein, YlmC YmxH family B7P25_20275 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7P25_20285 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) B7P25_20290 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) B7P25_20295 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) B7P25_20300 ENOG4105D4A Cell wall formation (By similarity) B7P25_20305 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B7P25_20310 ENOG4105CNI cell division protein FtsW B7P25_20325 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B7P25_20330 ENOG4105CJN penicillin-binding protein B7P25_20335 ENOG4105CJN penicillin-binding protein B7P25_20340 ENOG41068DC Essential cell division protein (By similarity) B7P25_20375 ENOG4105KNH Nucleic acid-binding protein B7P25_20385 ENOG41063PX domain protein B7P25_20390 ENOG4105D78 K07001 NTE family protein B7P25_20395 ENOG4105H20 Sporulation integral membrane protein YlbJ B7P25_20405 ENOG4106H78 methyltransferase B7P25_20425 ENOG4107TB6 phosphoglycerate mutase B7P25_20440 ENOG4106UY4 Inherit from COG: Scp-like extracellular B7P25_20490 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) B7P25_20500 ENOG4105CNI cell division protein FtsW B7P25_20515 ENOG4108IAB Phoh family B7P25_20535 ENOG4105QA2 B7P25_20540 ENOG4105CI3 gtp-binding protein typa B7P25_20550 ENOG4105ECY inositol monophosphatase B7P25_20570 ENOG4105CXN decarboxylase B7P25_20620 ENOG4105CPP Dehydrogenase, E1 component B7P25_20635 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B7P25_20640 ENOG4108X4Q Hydrolase B7P25_20655 ENOG4105CN5 Metallo-Beta-Lactamase B7P25_20660 ENOG4107ZYR domain protein B7P25_20695 ENOG4108XRC Protein of unknown function (DUF458) B7P25_20705 ENOG4107IN1 Protein of unknown function (DUF1797) B7P25_20720 ENOG4105EPM Diguanylate phosphodiesterase B7P25_20725 ENOG4105K6S Short-chain dehydrogenase reductase Sdr B7P25_20745 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) B7P25_20755 ENOG4105UIN B7P25_20825 ENOG4108HGU Histidine kinase B7P25_20835 ENOG4105CHM Aminotransferase B7P25_20840 ENOG4105FKQ transcriptional regulator B7P25_20845 ENOG4105EG2 ABC transporter, permease B7P25_20855 ENOG4107FKK extracellular solute-binding protein family 1 B7P25_20865 ENOG4105CG3 alpha amylase, catalytic region B7P25_20910 ENOG4105CHU acetyl-coa acetyltransferase B7P25_20950 ENOG4105DTD Dehydrogenase B7P25_20970 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B7P25_21010 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B7P25_21020 ENOG4106TD9 Diguanylate cyclase B7P25_21040 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) B7P25_21065 ENOG4105FDP GntR family transcriptional regulator B7P25_21120 ENOG4107ZE5 PPIases accelerate the folding of proteins B7P25_21125 ENOG4105PTM secreted protein B7P25_21130 ENOG4105J7I hydrolase B7P25_21140 ENOG4105G6R Stage v sporulation protein ae B7P25_21150 ENOG4105CZ3 stage V sporulation protein ad B7P25_21155 ENOG41090VF Stage v sporulation protein ac B7P25_21175 ENOG4105C8J )-transporter B7P25_21180 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7P25_21190 ENOG41082AN stage II sporulation protein B7P25_21195 ENOG4105DZ1 carboxypeptidase B7P25_21205 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B7P25_21210 ENOG4105DVE abc transporter atp-binding protein B7P25_21250 ENOG4105D7N magnesium and cobalt transport protein CorA B7P25_21275 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7P25_21285 ENOG4105I3K Ferric uptake regulator, Fur family B7P25_21290 ENOG4105MZ9 stage II sporulation protein m B7P25_21310 ENOG4105CPC Aldo Keto reductase B7P25_21320 ENOG4105RHY Pfam:UPF0157 B7P25_21340 ENOG4107SKW Inherit from COG: Alpha beta hydrolase B7P25_21350 ENOG4105ETE Transcriptional regulator (LacI family B7P25_21355 ENOG4108YM7 Gcn5-related n-acetyltransferase B7P25_21375 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) B7P25_21380 ENOG4108R6K riboflavin synthase, subunit alpha B7P25_21400 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) B7P25_21405 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B7P25_21410 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B7P25_21415 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B7P25_21425 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7P25_21440 ENOG4105DFD Na H antiporter B7P25_21445 ENOG4105CGH 5'-nucleotidase B7P25_21470 ENOG4105DBV ornithine carbamoyltransferase B7P25_21485 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) B7P25_21500 ENOG4108IXY short-chain dehydrogenase reductase B7P25_21505 ENOG41069FQ Metallo-beta-lactamase superfamily B7P25_21510 ENOG4105II7 pyrroline-5-carboxylate reductase B7P25_21515 ENOG4105EJQ L-serine dehydratase B7P25_21545 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B7P25_21555 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B7P25_21560 ENOG4105D9U N-acetyltransferase B7P25_21575 ENOG4108VZI ErfK ybiS ycfS ynhG family protein B7P25_21580 ENOG4108QEG Membrane B7P25_21585 ENOG4105CDA abc transporter atp-binding protein B7P25_21590 ENOG4105E5Q amino acid AbC transporter B7P25_21595 ENOG4108HW3 (ABC) transporter B7P25_21620 ENOG4108QY0 Membrane B7P25_21635 ENOG4105C7S Dehydrogenase B7P25_21640 ENOG4105CPP Dehydrogenase, E1 component B7P25_21660 ENOG4107RDP Dehydrogenase B7P25_21675 ENOG4108JUB Transcriptional regulator B7P25_21685 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B7P25_21700 ENOG4107QQR Sporulation B7P25_21710 ENOG4105S1Z Stage IV sporulation protein B B7P25_21715 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) B7P25_21725 ENOG4105DX0 Hemolysin A B7P25_21735 ENOG4105CTB Polyprenyl synthetase B7P25_21760 ENOG4108ZSR alkaline shock protein B7P25_21765 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B7P25_21790 ENOG410644B Stage III sporulation protein af B7P25_21800 ENOG4105KQ4 Stage iii sporulation protein ad B7P25_21805 ENOG4108CQH stage III sporulation protein AC B7P25_21810 ENOG4105KR5 Stage iii sporulation protein B7P25_21815 ENOG4105CD2 stage iii sporulation protein aa B7P25_21840 ENOG4105DC7 peptidase M24 B7P25_21855 ENOG4105CBJ Metal-dependent enzyme B7P25_21865 ENOG4107YBY Hydrolase B7P25_21885 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) B7P25_21890 ENOG4105WZW rhodanese family B7P25_21910 ENOG41080TC multidrug resistance protein B7P25_21955 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B7P25_21990 ENOG4105C0D helicase B7P25_22115 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B7P25_22120 ENOG4105C3R Methionine synthase B7P25_22130 ENOG4105C28 cystathionine B7P25_22135 ENOG4105C28 cystathionine B7P25_22155 ENOG4105C5X domain protein B7P25_22165 ENOG4105DKQ ROK family B7P25_22175 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase B7P25_22190 ENOG4108UTW Plays a role in the regulation of phosphate uptake B7P25_22195 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B7P25_22200 ENOG4105E2Z phosphate ABC transporter (Permease B7P25_22205 ENOG4105C8U phosphate abc transporter B7P25_22210 ENOG4105PWN phosphate abc transporter B7P25_22215 ENOG4107RF6 penicillin-binding protein B7P25_22225 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B7P25_22250 ENOG4105N80 Ferric uptake regulator, Fur family B7P25_22260 ENOG4105FDK ABC transporter B7P25_22265 ENOG4108JYZ YitT family B7P25_22270 ENOG41069ZM Protein of unknown function (DUF2624) B7P25_22295 ENOG4105EGD dinuclear metal center protein, YbgI family B7P25_22310 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7P25_22315 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B7P25_22355 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) B7P25_22360 ENOG4105KG3 cytidine deaminase B7P25_22365 ENOG4107YR5 Diacylglycerol kinase B7P25_22375 ENOG4105CTJ Metal Dependent Phosphohydrolase B7P25_22380 ENOG4105C9A Phoh family B7P25_22395 ENOG41068P3 sporulation protein YqfC B7P25_22400 ENOG4105KTH gatB Yqey B7P25_22415 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B7P25_22420 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) B7P25_22440 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ B7P25_22450 ENOG4105CSA Coproporphyrinogen iii oxidase B7P25_22455 ENOG4105KVH Transcriptional regulator B7P25_22480 ENOG4105TQK DNA polymerase iii, delta' subunit B7P25_22490 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 B7P25_22495 ENOG4108UK2 deaminase B7P25_22500 ENOG4105KQC Competence protein B7P25_22510 ENOG4105DXX methyltransferase B7P25_22520 ENOG4108WF2 Metal Dependent Phosphohydrolase B7P25_22530 ENOG410812S Rna-binding protein B7P25_22540 ENOG4105CQW ribosome biogenesis GTPase YqeH B7P25_22545 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase B7P25_22560 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7P25_22580 ENOG4108TVJ Nitroreductase B7P25_22595 ENOG4105G6Z alkaline phosphatase B7P25_22605 ENOG4108MUZ hydrolase B7P25_22640 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin B7P25_22645 ENOG4105MIR Phenylalanine 4-monooxygenase B7P25_22655 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B7P25_22695 ENOG4105S6R Iron-hydroxamate transporter permease subunit B7P25_22700 ENOG4108V5C ABC transporter B7P25_22715 ENOG4108EKI Dehydrogenase B7P25_22720 ENOG4105C28 cystathionine B7P25_22750 ENOG4107XRG penicillin-binding protein B7P25_22765 ENOG4105CFP Peptidase U32 B7P25_22770 ENOG4105XYU peptidase (U32 family) B7P25_22775 ENOG4108VQJ O-methyltransferase B7P25_22780 ENOG4105HHA aminodeoxychorismate lyase B7P25_22810 ENOG4105C02 permease B7P25_22825 ENOG41060CR B7P25_22830 ENOG4105C7H Helicase, RecD TraA family B7P25_22845 ENOG4105C3J Cysteine desulfurase B7P25_22855 ENOG4105D1H recombination factor protein RarA B7P25_22860 ENOG4108VCI transcription factor, rsfa family B7P25_22870 ENOG4105CUZ uba thif-type nad fad binding protein B7P25_22880 ENOG4105CUT histidyl-tRNA synthetase B7P25_22900 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B7P25_22910 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) B7P25_22915 ENOG41076HS cation diffusion facilitator family transporter B7P25_22920 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B7P25_22930 ENOG4105CKP Polysaccharide Biosynthesis Protein B7P25_22935 ENOG4108QG2 Membrane B7P25_22945 ENOG4105VIE preprotein translocase, subunit YajC B7P25_22960 ENOG41061AI Protein of unknown function (DUF2905) B7P25_22975 ENOG4108HUF Transporter B7P25_23010 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase B7P25_23015 ENOG4108IYU L-aspartate oxidase B7P25_23030 ENOG4108RPX mosc domain containing protein B7P25_23035 ENOG4105CQC Prephenate dehydratase B7P25_23055 ENOG4105EWM Histidine kinase B7P25_23080 ENOG4105X36 (ribosomal) protein B7P25_23090 ENOG4105C03 ribonuclease B7P25_23105 ENOG4107QMS site-determining protein B7P25_23120 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) B7P25_23125 ENOG4105DFF Rod shape-determining protein mreb B7P25_23150 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase B7P25_23155 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) B7P25_23165 ENOG41068KH stage VI sporulation protein D B7P25_23175 ENOG4105D52 delta-aminolevulinic acid dehydratase B7P25_23200 ENOG4105K56 Transcriptional regulator B7P25_23220 ENOG4108IUQ atp-dependent protease B7P25_23250 ENOG4108QCI YvbH-like oligomerisation region B7P25_23275 ENOG4105M59 Phosphodiesterase, mj0936 family B7P25_23290 ENOG4108XJQ germination protein B7P25_23300 ENOG4108PCX Major Facilitator B7P25_23310 ENOG4105KBX Transcriptional regulator, TetR family B7P25_23325 ENOG4105PFC Transcriptional regulator B7P25_23335 ENOG4105DZC cytosine deaminase B7P25_23340 ENOG41067S9 phage shock protein C, PspC B7P25_23345 ENOG4108JCI Transcriptional regulator B7P25_23355 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) B7P25_23360 ENOG4108Z40 Transcriptional regulator B7P25_23370 ENOG4108IUX (ABC) transporter B7P25_23375 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family B7P25_23380 ENOG4105ER2 Ompa motb domain protein B7P25_23385 ENOG4105E14 MotA TolQ exbB proton channel B7P25_23390 ENOG4108VXD carboxy-peptidase B7P25_23400 ENOG4105E33 succinate dehydrogenase B7P25_23410 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit B7P25_23425 ENOG4105K63 Thioredoxin B7P25_23430 ENOG4105C10 Electron transfer flavoprotein B7P25_23435 ENOG4105BZJ Electron transfer flavoprotein B7P25_23440 ENOG41060WC Enoyl-CoA hydratase B7P25_23445 ENOG4107Z3H Transcriptional regulator, TetR family B7P25_23450 ENOG4105CEY Amp-dependent synthetase and ligase B7P25_23465 ENOG4105J76 Periplasmic binding protein B7P25_23470 ENOG4105S6R Iron-hydroxamate transporter permease subunit B7P25_23510 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7P25_23525 ENOG4105DR4 Methyltransferase B7P25_23540 ENOG4105KFN sortase, SrtB family B7P25_23545 ENOG4105E0A ABC, transporter B7P25_23560 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) B7P25_23565 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) B7P25_23575 ENOG4105FE9 pseudouridine synthase B7P25_23590 ENOG4105DCG PHP domain protein B7P25_23625 ENOG4105C5S asparaginyl-tRNA synthetase B7P25_23640 ENOG4108RWN rrna methyltransferase B7P25_23660 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7P25_23665 ENOG4105CW7 secretion protein, HlyD family B7P25_23670 ENOG4108JGH Tetr family transcriptional regulator B7P25_23675 ENOG4105CN9 Peptidase m42 family protein B7P25_23695 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) B7P25_23700 ENOG4105C22 threonyL-tRNA synthetase B7P25_23705 ENOG4108TDW sporulation protein YtxC B7P25_23725 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B7P25_23735 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B7P25_23740 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) B7P25_23750 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) B7P25_23755 ENOG4105C2M dna polymerase I B7P25_23760 ENOG4105BZU Histidine kinase B7P25_23765 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7P25_23790 ENOG4108HMX isocitrate dehydrogenase (NADP) B7P25_23795 ENOG4105BZN citrate synthase B7P25_23810 ENOG4108REF Sporulation integral membrane protein ytvi B7P25_23815 ENOG4105FS0 cytoplasmic membrane protein B7P25_23840 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B7P25_23850 ENOG4105C0B DNA polymerase III (alpha subunit) B7P25_23855 ENOG4105VV2 B7P25_23865 ENOG4105SFS phosphoesterase RecJ domain protein B7P25_23905 ENOG4105DC7 peptidase M24 B7P25_23950 ENOG41082W1 Cupin 2, conserved barrel domain protein B7P25_23960 ENOG4105VZ8 Transcriptional regulator B7P25_23980 ENOG4107YZX Universal stress protein B7P25_24030 ENOG4108JYZ YitT family B7P25_24050 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) B7P25_24060 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) B7P25_24065 ENOG4105KBJ sporulation protein ytfj B7P25_24080 ENOG4105EFZ amidohydrolase B7P25_24090 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B7P25_24115 ENOG4106KR7 LysR family Transcriptional regulator B7P25_24125 ENOG4105U5Y Transcriptional regulator B7P25_24135 ENOG4105C28 cystathionine B7P25_24170 ENOG4105EMN RNA polymerase sigma factor B7P25_24190 ENOG4105F1V Acetoin utilization protein B7P25_24195 ENOG4105W87 Cbs domain B7P25_24200 ENOG4105DGU Histone deacetylase B7P25_24205 ENOG4106HB6 Alpha beta hydrolase B7P25_24210 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7P25_24220 ENOG4107SNB ankyrin repeat protein YahD B7P25_24225 ENOG4105EP9 oxidoreductase B7P25_24255 ENOG4105ETE Transcriptional regulator (LacI family B7P25_24285 ENOG4105C88 aminopeptidase B7P25_24310 ENOG4108IPJ Membrane B7P25_24320 ENOG4105K7K Transcriptional regulator B7P25_24355 ENOG4108VDD TRNA binding domain protein B7P25_24385 ENOG4105C8F Beta-lactamase domain protein B7P25_24400 ENOG4108V15 phosphotransferase enzyme family B7P25_24405 ENOG4108IUM Glycogen debranching enzyme B7P25_24420 ENOG4107QSE Dipeptidase B7P25_24425 ENOG4105YW5 deoR family transcriptional regulator B7P25_24440 ENOG4105CBX hi0933 family B7P25_24485 ENOG4108VJ1 Transcriptional regulator (CarD family B7P25_24490 ENOG4107EXU Short-chain dehydrogenase reductase Sdr B7P25_24510 ENOG4108ZAF Molybdopterin B7P25_24515 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein B7P25_24520 ENOG4105CVM Molybdenum cofactor synthesis domain protein B7P25_24530 ENOG4105D06 uba thif-type nad fad binding protein B7P25_24535 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7P25_24555 ENOG41085GJ domain protein B7P25_24565 ENOG4105DWV Homoserine O-trans-acetylase B7P25_24575 ENOG4108B31 Spore germination protein B7P25_24610 ENOG410605W Major Facilitator B7P25_24615 ENOG4107S91 Sodium hydrogen exchanger B7P25_24620 ENOG4105NCW Trka-c domain protein B7P25_24635 ENOG4105C19 ABC transporter B7P25_24655 ENOG4105N5T Radical SAM Protein B7P25_24665 ENOG4105CIG ABC transporter B7P25_24695 ENOG4105E8V Alpha Beta Hydrolase Fold protein B7P25_24700 ENOG4108Z0R Transferase B7P25_24705 ENOG4105YVM Phosphoesterase, PA-phosphatase related B7P25_24710 ENOG4105BZF Glycosyl transferase (Group 1 B7P25_24720 ENOG4108RIR Molybdenum cofactor biosynthesis protein B7P25_24735 ENOG4108MK9 spermidine N(1)-acetyltransferase B7P25_24785 ENOG4105EGD dinuclear metal center protein, YbgI family B7P25_24790 ENOG4105BZU Histidine kinase B7P25_24795 ENOG4105BZU Histidine kinase B7P25_24800 ENOG4107S9D Alpha beta hydrolase B7P25_24820 ENOG4105D2X ABC transporter substrate-binding protein B7P25_24830 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component B7P25_24880 ENOG4108V2W Carbonate dehydratase B7P25_24885 ENOG4105C4M (Ubiquinol oxidase) subunit I B7P25_24890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B7P25_24940 ENOG41087YS Phage shock protein A B7P25_24970 ENOG4105BZU Histidine kinase B7P25_24975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_25000 ENOG4108UGV hypoxanthine phosphoribosyltransferase B7P25_25005 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) B7P25_25025 ENOG4105C19 ABC transporter B7P25_25040 ENOG4107ZTW SNARE associated Golgi B7P25_25055 ENOG4105C19 ABC transporter B7P25_25060 ENOG41086D8 Transcriptional regulator B7P25_25100 ENOG4105C6Z Gluconate B7P25_25105 ENOG4105FDP GntR family transcriptional regulator B7P25_25125 ENOG41069H0 dihydroorotase EC 3.5.2.3 B7P25_25160 ENOG4108IPT Naphthoate synthase B7P25_25165 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) B7P25_25170 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) B7P25_25175 ENOG4105E4F Isochorismate synthase B7P25_25180 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B7P25_25190 ENOG4105VEQ Cold shock protein B7P25_25225 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) B7P25_25245 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B7P25_25350 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation B7P25_25390 ENOG4105KT7 mgtC SapB transporter B7P25_25395 ENOG4107PBV potassium channel B7P25_25415 ENOG4105WG9 Conserved Protein B7P25_25425 ENOG4105CHM Aminotransferase B7P25_25430 ENOG4108ZB6 transcriptional regulator AsnC family B7P25_25435 ENOG4105C5I Dehydrogenase B7P25_25440 ENOG4108MUZ hydrolase B7P25_25450 ENOG4105C87 Aminotransferase class I and II B7P25_25465 ENOG4105Y38 Kinase-associated protein B B7P25_25475 ENOG4107R3E Citrate transporter B7P25_25495 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) B7P25_25500 ENOG4105KA0 thioesterase Superfamily protein B7P25_25520 ENOG4107QPH glycogen) synthase B7P25_25530 ENOG4105EJV Membrane B7P25_25535 ENOG4105WH5 Teichoic acid glycosylation protein B7P25_25545 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B7P25_25600 ENOG41069ER domain protein B7P25_25615 ENOG4105CEP NADH dehydrogenase B7P25_25645 ENOG4105EWC Purine nucleoside phosphorylase B7P25_25665 ENOG4108YX9 iron--sulfur cluster insertion protein erpA B7P25_25690 ENOG4108JJA ABC, transporter B7P25_25695 ENOG4105C4B ABC transporter, permease B7P25_25705 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA B7P25_25730 ENOG41083MR nifu domain-containing protein B7P25_25745 ENOG4108W5N phosphatidylglycerophosphatase a B7P25_25760 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7P25_25765 ENOG4105DYS nad(p)h dehydrogenase (quinone) B7P25_25775 ENOG4105D4U had-superfamily hydrolase, subfamily iia B7P25_25790 ENOG4105CBT Fructose-1,6-bisphosphatase B7P25_25810 ENOG4105MMD transcriptional regulator B7P25_25815 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) B7P25_25820 ENOG4107TXC Transcriptional regulator B7P25_25825 ENOG41090T1 Membrane B7P25_25850 ENOG4105FAA peptidase M23 B7P25_25860 ENOG4105KZD Domain of unknown function (DUF1805) B7P25_25865 ENOG4107R8B 5'-nucleotidase B7P25_25890 ENOG4105DIW FeS assembly protein SUFB B7P25_25895 ENOG4108UNV SUF system FeS assembly protein, NifU family B7P25_25900 ENOG4105C9B Cysteine desulfurase B7P25_25905 ENOG4105JRK feS assembly protein SufD B7P25_25910 ENOG4105C3K feS assembly ATPase SufC B7P25_25915 ENOG4105D01 (LipO)protein B7P25_25920 ENOG4105D01 (LipO)protein B7P25_25925 ENOG4108UMI ABC transporter, permease B7P25_25955 ENOG41080E8 Transcriptional regulator, Spx MgsR family B7P25_26070 ENOG4105DZ1 carboxypeptidase B7P25_26110 ENOG4108SUT Major Facilitator Superfamily B7P25_26115 ENOG4107R7I amino acid B7P25_26125 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins B7P25_26135 ENOG4107AYK membrAne B7P25_26175 ENOG4107ZTW SNARE associated Golgi B7P25_26185 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein B7P25_26190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_26195 ENOG4105BZU Histidine kinase B7P25_26215 ENOG4105C8Q Methyl-accepting chemotaxis B7P25_26220 ENOG4105C8Q Methyl-accepting chemotaxis B7P25_26225 ENOG4105VG1 fes assembly suf system protein B7P25_26230 ENOG4105D4Y metalloprotease B7P25_26250 ENOG4107S91 Sodium hydrogen exchanger B7P25_26255 ENOG4105NCW Trka-c domain protein B7P25_26270 ENOG4108RMU ferritin dps family protein B7P25_26290 ENOG4108URH decarboxylase B7P25_26310 ENOG4105D9N nucleoside B7P25_26315 ENOG4105D9N nucleoside B7P25_26325 ENOG4108RYK Nad-dependent epimerase dehydratase B7P25_26345 ENOG4105CV8 reductase B7P25_26350 ENOG4105F27 Major Facilitator B7P25_26355 ENOG4105KVH Transcriptional regulator B7P25_26370 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B7P25_26385 ENOG4105C8Q Methyl-accepting chemotaxis B7P25_26415 ENOG4108MK9 spermidine N(1)-acetyltransferase B7P25_26420 ENOG4108VY7 phosphate-starvation-inducible protein PsiE B7P25_26440 ENOG4108IPW abc transporter atp-binding protein B7P25_26445 ENOG4105CM4 permease protein B7P25_26480 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) B7P25_26490 ENOG4105XZU Preprotein translocase, subunit SecG B7P25_26495 ENOG41067MG lrgb family B7P25_26515 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) B7P25_26545 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7P25_26600 ENOG41090VF Stage v sporulation protein ac B7P25_26605 ENOG4105CZ3 stage V sporulation protein ad B7P25_26620 ENOG4108QY0 Membrane B7P25_26625 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B7P25_26630 ENOG4105KRI phosphocarrier protein (HPr B7P25_26640 ENOG4105CHW UPF0052 protein B7P25_26650 ENOG4108Z4K mutator MutT protein B7P25_26660 ENOG4105C3M thioredoxin reductase B7P25_26670 ENOG4108S4C acetyltransferase B7P25_26690 ENOG41086DT Membrane protein of unknown function B7P25_26700 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B7P25_26705 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) B7P25_26720 ENOG4107TXC Transcriptional regulator B7P25_26750 ENOG4105DUM transcriptional regulator, lysR family B7P25_26760 ENOG4108WS4 fmn reductase B7P25_26775 ENOG4105BZ1 (ABC) transporter B7P25_26780 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B7P25_26785 ENOG4107RSM transcriptional regulator B7P25_26795 ENOG4105CN1 protease B7P25_26800 ENOG4105CRP Part of the ABC transporter FtsEX involved in B7P25_26805 ENOG4105CAK Cell division ATP-binding protein ftsE B7P25_26815 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) B7P25_26830 ENOG4105MS2 ribosomal subunit Interface protein B7P25_26835 ENOG4105VEQ Cold shock protein B7P25_26840 ENOG41081UC Inherit from COG: Competence protein B7P25_26855 ENOG4105KVH Transcriptional regulator B7P25_26870 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein B7P25_26875 ENOG4108KGH TRANSCRIPTIONal B7P25_26880 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase B7P25_26885 ENOG4105C6Y Udp-glucose 6-dehydrogenase B7P25_26890 ENOG4105ESV Glycosyl transferase, family 4 B7P25_26900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family B7P25_26915 ENOG410901P UPF0249 protein B7P25_26920 ENOG4105F8D glycoside hydrolase family 4 B7P25_26925 ENOG4105VCP PTS System B7P25_26930 ENOG4105CK1 PTS System B7P25_26940 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B7P25_26945 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B7P25_26950 ENOG4105VCP PTS System B7P25_26960 ENOG4105VZJ PTS System B7P25_26980 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase B7P25_26985 ENOG4105ECB domain protein B7P25_26990 ENOG4107RSM transcriptional regulator B7P25_27025 ENOG4105DAA L-lactate B7P25_27050 ENOG4105DAA L-lactate B7P25_27060 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) B7P25_27075 ENOG4105E0M Sulfatase B7P25_27105 ENOG4107R8N Glycosyl transferase, family 2 B7P25_27115 ENOG4105C94 Transporter B7P25_27125 ENOG41069ER domain protein B7P25_27135 ENOG4105KBK Zinc finger, swim domain protein B7P25_27140 ENOG4105C0D helicase B7P25_27170 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7P25_27190 ENOG4107RBB ABC transporter, permease B7P25_27195 ENOG4105C19 ABC transporter B7P25_27215 ENOG4105CXY transporter B7P25_27230 ENOG4105BZU Histidine kinase B7P25_27235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_27240 ENOG4105DG6 mannose-6-phosphate isomerase B7P25_27245 ENOG4105DM4 PTS System B7P25_27260 ENOG4105CMR udp-glucose 4-epimerase B7P25_27270 ENOG4108KGH TRANSCRIPTIONal B7P25_27275 ENOG4105DG6 mannose-6-phosphate isomerase B7P25_27280 ENOG4105CJT Mannose-1-phosphate guanylyltransferase B7P25_27285 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) B7P25_27290 ENOG4108TJN glycosyl transferase group 1 B7P25_27295 ENOG4105C6Y Udp-glucose 6-dehydrogenase B7P25_27315 ENOG4105D3Q Sugar transferase B7P25_27320 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B7P25_27325 ENOG4108RB3 Capsular polysaccharide biosynthesis protein B7P25_27330 ENOG4107YJ4 chain length determinant protein B7P25_27335 ENOG4105HTX biosynthesis protein B7P25_27340 ENOG4107YJ4 chain length determinant protein B7P25_27355 ENOG4105MT0 Sporulation transcriptional regulator spoiiid B7P25_27365 ENOG4105FRN stage II sporulation protein B7P25_27380 ENOG4105DY9 regulatoR B7P25_27400 ENOG4106778 Protein of unknown function (DUF1146) B7P25_27405 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7P25_27410 ENOG4105C8S subunit m B7P25_27415 ENOG4105D65 subunit l B7P25_27445 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B7P25_27455 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B7P25_27460 ENOG4105BZU Histidine kinase B7P25_27510 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) B7P25_27515 ENOG41062M3 atp synthase B7P25_27545 ENOG4108YZG isomerase B7P25_27565 ENOG4108VGI doxx family B7P25_27570 ENOG4107XC4 flavin reductase domain protein, FMN-binding B7P25_27585 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B7P25_27595 ENOG4108ZXQ stage ii sporulation protein r B7P25_27600 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B7P25_27605 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) B7P25_27620 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) B7P25_27625 ENOG4105CBT Fructose-1,6-bisphosphatase B7P25_27635 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B7P25_27670 ENOG4105C1G acyl-Coa dehydrogenase B7P25_27675 ENOG4105C1G acyl-Coa dehydrogenase B7P25_27680 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7P25_27690 ENOG4105DF6 Fe-S oxidoreductase B7P25_27705 ENOG4105BZU Histidine kinase B7P25_27730 ENOG4105BZU Histidine kinase B7P25_27735 ENOG4105KCT ABC transporter B7P25_27740 ENOG4108M15 ABC transporter B7P25_27745 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) B7P25_27760 ENOG4105IIU Aminopeptidase B7P25_27780 ENOG4105EMN RNA polymerase sigma factor B7P25_27790 ENOG410684U Domain of unknown function (DUF1934) B7P25_27815 ENOG4105CYW agmatinase B7P25_27825 ENOG4105DXB Major Facilitator superfamily B7P25_27830 ENOG4107SWG transcriptional regulator MERR family B7P25_27835 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B7P25_27840 ENOG4105BZ4 penicillin-binding protein B7P25_27845 ENOG4108XFG YwhD family B7P25_27850 ENOG4108Z4T Peptidase M50 B7P25_27855 ENOG41069HH 4-oxalocrotonate tautomerase B7P25_27860 ENOG4105DCI Phosphohydrolase B7P25_27865 ENOG4108MES Periplasmic binding protein B7P25_27870 ENOG4105E0A ABC, transporter B7P25_27875 ENOG4105EHG Permease protein B7P25_27880 ENOG4105DQ5 transport system permease protein B7P25_27890 ENOG4108VCI transcription factor, rsfa family B7P25_27905 ENOG4108IJ2 phosphate acetyltransferase B7P25_27920 ENOG4108VKI Cell wall hydrolase B7P25_27940 ENOG4107SVH Potassium channel protein B7P25_27950 ENOG410667J hydrolase B7P25_27955 ENOG4105VCH membrane B7P25_27965 ENOG4108TU7 Inherit from COG: (ABC) transporter B7P25_27970 ENOG4105CJ1 ABC, transporter B7P25_27975 ENOG41090WU lipolytic protein G-D-S-L family B7P25_27990 ENOG4105D6E homoserine dehydrogenase B7P25_28015 ENOG4108Y4K DNA-binding transcriptional activator B7P25_28025 ENOG4105WH1 Two component transcriptional regulator luxr family B7P25_28030 ENOG4105BZU Histidine kinase B7P25_28035 ENOG4105DWF phosphomethylpyrimidine kinase B7P25_28040 ENOG4105BZU Histidine kinase B7P25_28045 ENOG4105VCD cytoplasmic protein B7P25_28050 ENOG4105D22 carbon starvation protein B7P25_28055 ENOG4105DY9 regulatoR B7P25_28060 ENOG41079KZ Major Facilitator Superfamily B7P25_28080 ENOG4105EN6 Membrane B7P25_28085 ENOG4106YBV Methyl-accepting chemotaxis B7P25_28095 ENOG4108S4H thioesterase Superfamily protein B7P25_28105 ENOG4105JEU Glycosyl transferase, family 2 B7P25_28110 ENOG4105C5H ABC transporter B7P25_28120 ENOG41067SE Tetr family transcriptional regulator B7P25_28130 ENOG4105E0X reductase B7P25_28135 ENOG4106F5Q Membrane B7P25_28150 ENOG4105DY9 regulatoR B7P25_28155 ENOG4108HRK Histidine kinase B7P25_28160 ENOG4107RGD Major Facilitator superfamily B7P25_28180 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B7P25_28190 ENOG4105IW1 AmiS UreI transporter B7P25_28200 ENOG4105CMR udp-glucose 4-epimerase B7P25_28205 ENOG4108UT2 hemolysin iii B7P25_28215 ENOG4105C1J atp-dependent rna helicase B7P25_28225 ENOG4105DPN Oligoendopeptidase f B7P25_28245 ENOG4105C0H protease B7P25_28250 ENOG4105Q2H domain protein B7P25_28265 ENOG4105BZU Histidine kinase B7P25_28270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7P25_28300 ENOG4105CDU Replicative dna helicase B7P25_28310 ENOG4105BZR domain protein B7P25_28315 ENOG4108XMW Membrane B7P25_28325 ENOG4108UUM single-stranded DNA-binding protein B7P25_28335 ENOG4105C3G gtp-binding protein B7P25_28340 ENOG4105VDK protein, conserved in bacteria B7P25_28345 ENOG4105D8X mechanosensitive ion channel B7P25_28350 ENOG4108ZDA Sporulation protein YyaC B7P25_28355 ENOG4105FA0 parb-like partition protein B7P25_28360 ENOG4107QJE Chromosome Partitioning Protein B7P25_28380 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) B7P25_28390 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins