locus-tag class description FBF59_00005 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FBF59_00010 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FBF59_00030 ENOG4105VB6 UPF0109 protein FBF59_00055 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FBF59_00070 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FBF59_00075 ENOG4105C79 DNA protecting protein DprA FBF59_00080 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FBF59_00090 ENOG4108HE4 integrase family FBF59_00120 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FBF59_00130 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FBF59_00135 ENOG4105KNE Phosphatidate cytidylyltransferase FBF59_00140 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FBF59_00145 ENOG4105DZP Membrane-associated zinc metalloprotease FBF59_00155 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FBF59_00165 ENOG4105CHV Transcription elongation factor NusA FBF59_00170 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FBF59_00175 ENOG4105VHM ribosomal protein FBF59_00185 ENOG4105W7A Protein of unknown function (DUF503) FBF59_00200 ENOG4105DTN riboflavin biosynthesis protein ribF FBF59_00220 ENOG4105C1V Peptidase, M16 FBF59_00230 ENOG4105E35 Dipicolinate synthase subunit A FBF59_00255 ENOG4108IMY Transcriptional regulator FBF59_00300 ENOG4105CDU Replicative dna helicase FBF59_00460 ENOG4108IBT Inherit from COG: transposase FBF59_00465 ENOG4108S0H Dipicolinic acid synthetase, b subunit FBF59_00470 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FBF59_00480 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FBF59_00490 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FBF59_00500 ENOG4105CNU cell division protein FtsK FBF59_00510 ENOG4105FDP GntR family transcriptional regulator FBF59_00515 ENOG4105DIH basic membrane FBF59_00520 ENOG4108JQ9 ABC transporter FBF59_00525 ENOG4105UIB (ABC) transporter FBF59_00545 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FBF59_00550 ENOG4105XZV Protein of unknown function (DUF3243) FBF59_00565 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FBF59_00585 ENOG4105D48 metallophosphoesterase FBF59_00590 ENOG4105MCT stage V sporulation protein S FBF59_00595 ENOG4108IGT Dipeptidase FBF59_00600 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FBF59_00605 ENOG4105DQU oxidoreductase, subunit beta FBF59_00640 ENOG410890F Dynamin family FBF59_00645 ENOG4105E0M Sulfatase FBF59_00660 ENOG4105F0V Cell wall hydrolase FBF59_00670 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FBF59_00675 ENOG4105C8Q Methyl-accepting chemotaxis FBF59_00700 ENOG41067MG lrgb family FBF59_00740 ENOG4105BZU Histidine kinase FBF59_00770 ENOG4105D03 DNA-3-methyladenine glycosylase II FBF59_00775 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FBF59_00785 ENOG4105CGK Exodeoxyribonuclease III FBF59_00805 ENOG4105E0A ABC, transporter FBF59_00810 ENOG4105NIV Esterase FBF59_00830 ENOG4105VPX protein, conserved in bacteria FBF59_00835 ENOG410681U heavy metal transport detoxification protein FBF59_00840 ENOG4105C59 p-type ATPase FBF59_00850 ENOG4105K70 DNA-binding protein FBF59_00855 ENOG4105TMB Formate nitrite transporter FBF59_00880 ENOG4105C85 amino acid FBF59_00890 ENOG4108SJC Membrane FBF59_00895 ENOG4107QW4 alcohol dehydrogenase FBF59_00900 ENOG4105E98 transcriptional regulator DeoR family FBF59_00905 ENOG4105DE4 1-phosphofructokinase FBF59_00910 ENOG4105DM4 PTS System FBF59_00915 ENOG41069ER domain protein FBF59_00945 ENOG4106F1P AAA ATPase, central domain protein FBF59_00950 ENOG4105EN6 Membrane FBF59_00955 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FBF59_00960 ENOG4105CXI aluminum resistance protein FBF59_00965 ENOG4105KV4 Transcriptional regulator FBF59_00970 ENOG4105C5F glutamine synthetase FBF59_01005 ENOG41065S2 pneumococcal vaccine antigen FBF59_01010 ENOG4105E4C Lytic transglycosylase catalytic FBF59_01020 ENOG4105K7K Transcriptional regulator FBF59_01040 ENOG4108SVB resolvase FBF59_01050 ENOG4105CGH 5'-nucleotidase FBF59_01055 ENOG4108HW3 (ABC) transporter FBF59_01090 ENOG4105BZ1 (ABC) transporter FBF59_01095 ENOG4105BZ1 (ABC) transporter FBF59_01135 ENOG41067MG lrgb family FBF59_01140 ENOG4105VAW lrga family FBF59_01145 ENOG4107RSM transcriptional regulator FBF59_01165 ENOG4105CJ1 ABC, transporter FBF59_01175 ENOG4105CH2 amidohydrolase FBF59_01190 ENOG4107QIV Cytochrome c biogenesis protein FBF59_01250 ENOG4108903 Formimidoylglutamase FBF59_01255 ENOG4108VJ1 Transcriptional regulator (CarD family FBF59_01260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FBF59_01265 ENOG4105CBC glutamate synthase FBF59_01275 ENOG4105CK7 Sodium proline symporter FBF59_01280 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FBF59_01285 ENOG4105FBA Phospholipase Carboxylesterase FBF59_01290 ENOG4105BZU Histidine kinase FBF59_01305 ENOG4107AYK membrAne FBF59_01340 ENOG4108IMY Transcriptional regulator FBF59_01345 ENOG4105CEY Amp-dependent synthetase and ligase FBF59_01350 ENOG4107ZYJ bioY protein FBF59_01355 ENOG4107F3J Amp-dependent synthetase and ligase FBF59_01375 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FBF59_01385 ENOG4105E5W Transporter FBF59_01415 ENOG4108I0Z Aconitate hydratase FBF59_01420 ENOG4108JJB ABC transporter FBF59_01430 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FBF59_01435 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FBF59_01460 ENOG4105W8X HesB YadR YfhF-family protein FBF59_01465 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FBF59_01470 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FBF59_01480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_01485 ENOG4105C0H protease FBF59_01490 ENOG4105K4P CoA-binding domain protein FBF59_01495 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FBF59_01505 ENOG4105D9R oxidoreductase FBF59_01525 ENOG4105CIG ABC transporter FBF59_01535 ENOG4105EMN RNA polymerase sigma factor FBF59_01545 ENOG4108KGH TRANSCRIPTIONal FBF59_01550 ENOG4107QJT sodium dicarboxylate symporter FBF59_01625 ENOG4108JB9 formate dehydrogenase FBF59_01675 ENOG4108NF7 phage-type endonuclease FBF59_01680 ENOG4108PNI recT protein FBF59_01720 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FBF59_01730 ENOG4105WXW Antirepressor FBF59_01755 ENOG4108C33 Resolvase FBF59_01855 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FBF59_01905 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FBF59_01910 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FBF59_01920 ENOG4105TMB Formate nitrite transporter FBF59_01925 ENOG4105D06 uba thif-type nad fad binding protein FBF59_01930 ENOG4105CVM Molybdenum cofactor synthesis domain protein FBF59_01935 ENOG4108ZAF Molybdopterin FBF59_01945 ENOG4105D1F ATP-binding protein FBF59_01960 ENOG410696E Membrane FBF59_01965 ENOG4105FR1 rard protein FBF59_01975 ENOG4105EWU Squalene--hopene cyclase FBF59_01985 ENOG4105CHR reductase FBF59_01990 ENOG4105C26 Dehydrogenase FBF59_02000 ENOG4108IA2 Sodium pantothenate symporter FBF59_02015 ENOG4106IQC argininosuccinate lyase FBF59_02025 ENOG410904N short-chain dehydrogenase reductase FBF59_02045 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FBF59_02065 ENOG4105VEQ Cold shock protein FBF59_02080 ENOG4108R1P FBF59_02090 ENOG41073R8 VanW family FBF59_02095 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FBF59_02105 ENOG4105KT7 mgtC SapB transporter FBF59_02115 ENOG4105BZU Histidine kinase FBF59_02135 ENOG4107DUR UPF0457 protein FBF59_02140 ENOG4108VXD carboxy-peptidase FBF59_02175 ENOG4108IMY Transcriptional regulator FBF59_02320 ENOG4105CAR Terminase, large subunit FBF59_02330 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FBF59_02390 ENOG4105XSJ toxin secretion phage lysis holin FBF59_02455 ENOG41067SE Tetr family transcriptional regulator FBF59_02465 ENOG4105BZU Histidine kinase FBF59_02510 ENOG4105FAW cDP-glucose 4,6-dehydratase FBF59_02525 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FBF59_02545 ENOG4105E1K spore germination protein FBF59_02555 ENOG4108M1A Chitin-binding protein FBF59_02560 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FBF59_02585 ENOG4105C5E polysaccharide biosynthesis protein FBF59_02590 ENOG4105C1B dTDP-glucose 4-6-dehydratase FBF59_02595 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FBF59_02600 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FBF59_02615 ENOG4105D2T synthase FBF59_02640 ENOG4105CEP NADH dehydrogenase FBF59_02660 ENOG4105CQB FAD linked oxidase domain protein FBF59_02665 ENOG4105C09 Bile acid FBF59_02685 ENOG4105CIS alcohol dehydrogenase FBF59_02690 ENOG41082BM Transcriptional regulator, arsr family FBF59_02700 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FBF59_02725 ENOG4108A04 Beta-lactamase FBF59_02760 ENOG4105DPN Oligoendopeptidase f FBF59_02765 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FBF59_02770 ENOG4105E5K Alpha-amylase FBF59_02780 ENOG4105C98 muts2 protein FBF59_02800 ENOG4107V2S Transcriptional regulator FBF59_02810 ENOG4107CUJ Protein of unknown function (DUF2690) FBF59_02830 ENOG4105NX3 Membrane FBF59_02835 ENOG4105WCN acetyltransferase FBF59_02845 ENOG4107R3E Citrate transporter FBF59_02855 ENOG4108TN2 lmbE family FBF59_02895 ENOG4105CIS alcohol dehydrogenase FBF59_02930 ENOG4105H3G oxidoreductase FBF59_02970 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FBF59_03025 ENOG4108ZJ4 polysaccharide deacetylase FBF59_03040 ENOG4107SCK Monooxygenase FBF59_03045 ENOG4105KVH Transcriptional regulator FBF59_03050 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FBF59_03065 ENOG4105JAB phenazine biosynthesis protein, phzf family FBF59_03110 ENOG4105D9R oxidoreductase FBF59_03115 ENOG4108TZY GntR Family Transcriptional Regulator FBF59_03120 ENOG4105KVH Transcriptional regulator FBF59_03150 ENOG4105C44 Serine transporter FBF59_03170 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FBF59_03175 ENOG4105CV1 Transketolase (EC 2.2.1.1) FBF59_03185 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FBF59_03190 ENOG4105CMG Carbohydrate kinase FBF59_03195 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FBF59_03200 ENOG4105XDF Protein of unknown function (DUF1272) FBF59_03205 ENOG4105DDN Pentapeptide repeat-containing protein FBF59_03230 ENOG4105C37 (CBS) domain FBF59_03260 ENOG4105EV4 Multidrug resistance protein mdtH FBF59_03270 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FBF59_03305 ENOG4105C31 Tryptophanyl-tRNA synthetase FBF59_03310 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FBF59_03320 ENOG4108UW5 maltose o-acetyltransferase FBF59_03325 ENOG4106UW1 Major Facilitator superfamily FBF59_03330 ENOG4105DKQ ROK family FBF59_03335 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FBF59_03400 ENOG4108PSK reductase FBF59_03430 ENOG4108RCM Nitroreductase FBF59_03435 ENOG4105KVH Transcriptional regulator FBF59_03455 ENOG4108Z66 YbaK ebsC protein FBF59_03460 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FBF59_03470 ENOG4108K8S endonuclease I FBF59_03530 ENOG4105DYS nad(p)h dehydrogenase (quinone) FBF59_03545 ENOG4105CRW Short chain fatty acid transporter FBF59_03555 ENOG4105CZM Major Facilitator FBF59_03560 ENOG4107MII Sugar-specific transcriptional regulator TrmB FBF59_03575 ENOG4108ISG Major Facilitator FBF59_03585 ENOG4105PNM synthesis protein FBF59_03590 ENOG4108VXD carboxy-peptidase FBF59_03615 ENOG4107EV6 Inherit from COG: YD repeat protein FBF59_03730 ENOG4108IG5 Transcriptional regulator FBF59_03740 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FBF59_03760 ENOG410874W AraC family transcriptional regulator FBF59_03770 ENOG41082W1 Cupin 2, conserved barrel domain protein FBF59_03785 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FBF59_03790 ENOG4108JQ1 Dehydrogenase FBF59_03815 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FBF59_03825 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FBF59_03830 ENOG4108U05 Transcriptional regulator FBF59_03845 ENOG4105BZU Histidine kinase FBF59_03865 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FBF59_03885 ENOG4105JQZ Methyltransferase FBF59_03905 ENOG4105K6H D-cysteine desulfhydrase FBF59_03915 ENOG4105C0R drug resistance transporter emrb qaca subfamily FBF59_03920 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FBF59_03955 ENOG4105C19 ABC transporter FBF59_03970 ENOG4105DNP FAD linked oxidase domain protein FBF59_04010 ENOG4105BZU Histidine kinase FBF59_04015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_04060 ENOG4108YXU transcriptional regulator AsnC family FBF59_04065 ENOG4105CHR reductase FBF59_04070 ENOG4108IG5 Transcriptional regulator FBF59_04075 ENOG4107P5I polyketide synthase FBF59_04085 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FBF59_04100 ENOG4105VZ8 Transcriptional regulator FBF59_04140 ENOG4105EGI Transcriptional regulator FBF59_04155 ENOG41085FC arsR family transcriptional regulator FBF59_04160 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FBF59_04165 ENOG4105D6J arsenicaL-resistance protein FBF59_04185 ENOG4105DIK (ABC) transporter FBF59_04190 ENOG4105CC5 ABC transporter FBF59_04195 ENOG4105DSE periplasmic solute binding protein FBF59_04200 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FBF59_04215 ENOG4107VMI polysaccharide deacetylase FBF59_04220 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FBF59_04225 ENOG4108TWJ NADH dehydrogenase subunit 5 FBF59_04240 ENOG4105CVP deoxyribo-dipyrimidine photolyase FBF59_04245 ENOG4108606 TspO/MBR family FBF59_04260 ENOG4105F6J Alpha beta hydrolase fold FBF59_04290 ENOG41090MY MarR family Transcriptional regulator FBF59_04315 ENOG4105CHJ isochorismatase hydrolase FBF59_04325 ENOG4105CGH 5'-nucleotidase FBF59_04345 ENOG4106A3M Cytochrome p-450 FBF59_04380 ENOG4108Q8B Spore germination protein FBF59_04390 ENOG4105II7 pyrroline-5-carboxylate reductase FBF59_04395 ENOG4105CUB amino acid FBF59_04400 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FBF59_04405 ENOG4105YWU small acid-soluble spore protein FBF59_04420 ENOG41075H3 AraC family transcriptional regulator FBF59_04445 ENOG4105BZU Histidine kinase FBF59_04455 ENOG4108B31 Spore germination protein FBF59_04475 ENOG4108IMY Transcriptional regulator FBF59_04485 ENOG4108IJ0 Aspartate ammonia-lyase FBF59_04495 ENOG4105E2A Dehydrogenase FBF59_04525 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FBF59_04565 ENOG4105DWD nucleoside recognition domain protein FBF59_04580 ENOG4105FDT acyl-CoA dehydrogenase FBF59_04590 ENOG4108ZHR arsR family transcriptional regulator FBF59_04595 ENOG4106N3A copper homeostasis protein cutc FBF59_04605 ENOG4107258 Transcriptional regulator FBF59_04610 ENOG4105P4J Allophanate hydrolase, subunit 1 FBF59_04640 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FBF59_04645 ENOG4107RF6 penicillin-binding protein FBF59_04675 ENOG4105BZU Histidine kinase FBF59_04685 ENOG4108VJ1 Transcriptional regulator (CarD family FBF59_04740 ENOG4108IQI permease FBF59_04750 ENOG410635A Membrane FBF59_04800 ENOG4108PCN EamA-like transporter family FBF59_04805 ENOG4105E09 nadh pyrophosphatase FBF59_04815 ENOG4108XET gCN5-related N-acetyltransferase FBF59_04840 ENOG4105C19 ABC transporter FBF59_04845 ENOG4105CMR udp-glucose 4-epimerase FBF59_04850 ENOG4105WEC Molybdate metabolism regulator FBF59_04855 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FBF59_04875 ENOG4105FS7 Transcriptional regulator FBF59_04880 ENOG4108TVJ Nitroreductase FBF59_04905 ENOG41090AA FBF59_04940 ENOG4105C8Y Acetylornithine aminotransferase FBF59_04965 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FBF59_05000 ENOG41068WN FBF59_05020 ENOG4105VMP Transcriptional regulator FBF59_05030 ENOG4105G6Z alkaline phosphatase FBF59_05035 ENOG4107RBI VanW family FBF59_05045 ENOG4105ECK Fatty Acid Desaturase FBF59_05050 ENOG4105E0Y RtcB Protein FBF59_05070 ENOG4107258 Transcriptional regulator FBF59_05080 ENOG4105II7 pyrroline-5-carboxylate reductase FBF59_05110 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FBF59_05125 ENOG41061GT Aldolase FBF59_05135 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FBF59_05140 ENOG4105DKT Transcriptional regulator FBF59_05150 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FBF59_05160 ENOG4105D4B ABC, transporter FBF59_05190 ENOG41069ER domain protein FBF59_05230 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FBF59_05235 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FBF59_05260 ENOG41082JN Transcriptional regulator FBF59_05265 ENOG4105EYF MMPL domain protein FBF59_05270 ENOG4105C5H ABC transporter FBF59_05275 ENOG4105E0M Sulfatase FBF59_05280 ENOG4108ZCF integral membrane protein FBF59_05300 ENOG4107VMI polysaccharide deacetylase FBF59_05315 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FBF59_05320 ENOG4105C6T cysteine synthase FBF59_05325 ENOG4107VC0 DNA alkylation repair enzyme FBF59_05360 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FBF59_05385 ENOG4105D7T ABC transporter FBF59_05390 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FBF59_05395 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FBF59_05410 ENOG4105C02 permease FBF59_05460 ENOG4105CHM Aminotransferase FBF59_05495 ENOG41089UC methyltransferase, type 11 FBF59_05510 ENOG4107BMA Transglycosylase associated protein FBF59_05535 ENOG4106K7D Major facilitator family transporter FBF59_05540 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FBF59_05600 ENOG4105EPR degv family FBF59_05605 ENOG4105DPN Oligoendopeptidase f FBF59_05630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_05635 ENOG4105BZU Histidine kinase FBF59_05640 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FBF59_05645 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FBF59_05680 ENOG4107SET aldo keto reductase FBF59_05695 ENOG4105DTQ mandelate racemase muconate lactonizing FBF59_05710 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FBF59_05720 ENOG4107T5V SNARE associated Golgi FBF59_05755 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FBF59_05765 ENOG41080HI glycine oxidase FBF59_05770 ENOG4105CTU Proline racemase FBF59_05780 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FBF59_05785 ENOG4105C26 Dehydrogenase FBF59_05790 ENOG4105BZG amino acid carrier protein FBF59_05810 ENOG4108M1A Chitin-binding protein FBF59_05865 ENOG4105C9U ATP-dependent DNA helicase RecQ FBF59_05880 ENOG4105EEM helicase FBF59_05885 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FBF59_05910 ENOG4108Z7F N-acetyltransferase FBF59_05935 ENOG4105MSB protein, conserved in bacteria FBF59_05940 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FBF59_05955 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FBF59_05965 ENOG41087PP glycosyltransferase MGT family FBF59_05970 ENOG4108M1A Chitin-binding protein FBF59_05990 ENOG41082BV acetyltransferase FBF59_05995 ENOG4105E66 phosphoriboisomerase A FBF59_06010 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FBF59_06020 ENOG4108IJ7 Glycine betaine FBF59_06025 ENOG4107SQ8 Glycine betaine FBF59_06065 ENOG4105RHY Pfam:UPF0157 FBF59_06070 ENOG4105E1F short-chain dehydrogenase reductase FBF59_06080 ENOG4107RUY (E1 component), alpha subunit FBF59_06090 ENOG4107QKR Dehydrogenase FBF59_06110 ENOG41062ES Transcriptional regulator FBF59_06125 ENOG4105E98 transcriptional regulator DeoR family FBF59_06140 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FBF59_06165 ENOG4107Z3H Transcriptional regulator, TetR family FBF59_06170 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FBF59_06175 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FBF59_06210 ENOG4105MSI germination protein ypeb FBF59_06260 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FBF59_06265 ENOG4105FDR Membrane FBF59_06270 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FBF59_06275 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FBF59_06295 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FBF59_06305 ENOG4108IUM Glycogen debranching enzyme FBF59_06320 ENOG4105DY8 decarboxylase FBF59_06335 ENOG4107WD8 ABC transporter, permease FBF59_06355 ENOG4105BZU Histidine kinase FBF59_06360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_06365 ENOG4105U0R haloacid dehalogenase-like hydrolase FBF59_06390 ENOG4107VFR oxidoreductase FBF59_06410 ENOG41087PP glycosyltransferase MGT family FBF59_06445 ENOG4105PKS Excinuclease abc c subunit domain protein FBF59_06455 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FBF59_06480 ENOG4105KWG Pfam:DUF1696 FBF59_06485 ENOG4108NRW Phospholipase, patatin family FBF59_06505 ENOG4108XI2 Domain of unknown function (DUF1963) FBF59_06530 ENOG4108Z4K mutator MutT protein FBF59_06535 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FBF59_06550 ENOG4105FCD Major Facilitator FBF59_06565 ENOG4105M6F mutator MutT protein FBF59_06570 ENOG4105EGD dinuclear metal center protein, YbgI family FBF59_06590 ENOG4107Y9U Membrane FBF59_06615 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FBF59_06630 ENOG4107Y80 Major Facilitator superfamily FBF59_06675 ENOG4105CJN penicillin-binding protein FBF59_06680 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FBF59_06685 ENOG4105CB2 alcohol dehydrogenase FBF59_06775 ENOG4108HGU Histidine kinase FBF59_06790 ENOG4108JJB ABC transporter FBF59_06815 ENOG4105F6S Spore photoproduct lyase FBF59_06825 ENOG4105XZV Protein of unknown function (DUF3243) FBF59_06835 ENOG4105ECP epimerase FBF59_06850 ENOG4105WG9 Conserved Protein FBF59_06865 ENOG4108606 TspO/MBR family FBF59_06870 ENOG4105CVP deoxyribo-dipyrimidine photolyase FBF59_06905 ENOG41082BM Transcriptional regulator, arsr family FBF59_06915 ENOG4105D9M gamma-glutamylcysteine synthetase FBF59_06925 ENOG4105C4W S-formylglutathione hydrolase FBF59_06935 ENOG4105KVH Transcriptional regulator FBF59_07000 ENOG4108VJ1 Transcriptional regulator (CarD family FBF59_07015 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FBF59_07060 ENOG4108FPN Integrase FBF59_07085 ENOG4107RF6 penicillin-binding protein FBF59_07090 ENOG4105BZU Histidine kinase FBF59_07095 ENOG410667J hydrolase FBF59_07200 ENOG4105ETU transcriptional activator (TenA FBF59_07205 ENOG4105CPF Cell wall formation (By similarity) FBF59_07215 ENOG4105D6E homoserine dehydrogenase FBF59_07260 ENOG4105CPC Aldo Keto reductase FBF59_07265 ENOG4106NZI LysR family Transcriptional regulator FBF59_07290 ENOG4105DK7 lysyl-tRNA synthetase FBF59_07300 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FBF59_07310 ENOG4108V4B ThiJ pfpI FBF59_07320 ENOG410900G Protein of unknown function (DUF421) FBF59_07390 ENOG4105KVH Transcriptional regulator FBF59_07395 ENOG4105CHR reductase FBF59_07405 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FBF59_07455 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FBF59_07470 ENOG4105T9C HD domain FBF59_07485 ENOG4105DZ1 carboxypeptidase FBF59_07525 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FBF59_07530 ENOG4107QX3 carboxylase FBF59_07535 ENOG4105E39 Enoyl-CoA hydratase FBF59_07540 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FBF59_07545 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FBF59_07550 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FBF59_07555 ENOG4105C1G acyl-Coa dehydrogenase FBF59_07570 ENOG4107Z3H Transcriptional regulator, TetR family FBF59_07590 ENOG4105DIN metallophosphoesterase FBF59_07600 ENOG4107RF6 penicillin-binding protein FBF59_07610 ENOG4107RF6 penicillin-binding protein FBF59_07625 ENOG4107RVG penicillin-binding protein FBF59_07665 ENOG4107VMI polysaccharide deacetylase FBF59_07685 ENOG4108IMY Transcriptional regulator FBF59_07730 ENOG4108SC4 )-transporter FBF59_07735 ENOG4105IIU Aminopeptidase FBF59_07745 ENOG4105FJR Lmbe family FBF59_07760 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FBF59_07765 ENOG4108IAJ Nad-dependent epimerase dehydratase FBF59_07770 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FBF59_07775 ENOG4107QQG Dehydrogenase FBF59_07780 ENOG4108W0I acetyltransferase FBF59_07855 ENOG4105CHR reductase FBF59_07865 ENOG4105W8Z 4'-phosphopantetheinyl transferase FBF59_07910 ENOG4105EJ9 Membrane FBF59_07920 ENOG4105KRN Transcriptional regulator, abrb family FBF59_07945 ENOG4105CIN aminoacyl-histidine dipeptidase FBF59_07985 ENOG4107RA9 decarboxylase FBF59_07990 ENOG4108I0C methyltransferase FBF59_08000 ENOG41088CC tellurite resistance protein tehB FBF59_08005 ENOG4105C1J atp-dependent rna helicase FBF59_08015 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FBF59_08030 ENOG4108INS Transcriptional regulator FBF59_08035 ENOG4105C7B Threonine dehydratase FBF59_08040 ENOG4107STF Involved in phosphonate degradation (By similarity) FBF59_08045 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FBF59_08050 ENOG4105RD7 BadF BadG BcrA BcrD FBF59_08075 ENOG4105F32 YngK protein FBF59_08095 ENOG4108KPJ rna polymerase sigma factor FBF59_08100 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FBF59_08130 ENOG4108JCI Transcriptional regulator FBF59_08160 ENOG4105BZ1 (ABC) transporter FBF59_08165 ENOG4105BZ1 (ABC) transporter FBF59_08180 ENOG4108RPX mosc domain containing protein FBF59_08185 ENOG4105DND Transcriptional regulator FBF59_08200 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FBF59_08205 ENOG4107V2S Transcriptional regulator FBF59_08235 ENOG41068WN FBF59_08245 ENOG4105C1Q protoporphyrinogen oxidase FBF59_08270 ENOG4105WCN acetyltransferase FBF59_08295 ENOG4105EYF MMPL domain protein FBF59_08305 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FBF59_08325 ENOG4108Y4K DNA-binding transcriptional activator FBF59_08335 ENOG41081I9 integral membrane protein FBF59_08370 ENOG4105C19 ABC transporter FBF59_08375 ENOG4105C22 threonyL-tRNA synthetase FBF59_08380 ENOG4105FE9 pseudouridine synthase FBF59_08400 ENOG4105BZG amino acid carrier protein FBF59_08420 ENOG4105K70 DNA-binding protein FBF59_08435 ENOG4105C0R drug resistance transporter emrb qaca subfamily FBF59_08440 ENOG4105WQT MbtH domain protein FBF59_08445 ENOG4105CEY Amp-dependent synthetase and ligase FBF59_08450 ENOG4105WQI isochorismatase FBF59_08455 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FBF59_08460 ENOG4105E4F Isochorismate synthase FBF59_08465 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FBF59_08470 ENOG4105FCD Major Facilitator FBF59_08485 ENOG4105EYH Exonuclease FBF59_08490 ENOG4107RFY SbcCD D subunit FBF59_08505 ENOG4105E39 Enoyl-CoA hydratase FBF59_08510 ENOG4105N14 lysine exporter protein LysE YggA FBF59_08520 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FBF59_08525 ENOG4105C1G acyl-Coa dehydrogenase FBF59_08530 ENOG4105CR4 methylisocitrate lyase FBF59_08535 ENOG4105DXD 2-methylcitrate dehydratase FBF59_08545 ENOG4105W8X HesB YadR YfhF-family protein FBF59_08550 ENOG4105CZM Major Facilitator FBF59_08560 ENOG4105BZ4 penicillin-binding protein FBF59_08615 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FBF59_08660 ENOG4105SZ6 Thioredoxin FBF59_08670 ENOG410841Q phosphoesterase PA-phosphatase related protein FBF59_08715 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FBF59_08720 ENOG4108JUB Transcriptional regulator FBF59_08725 ENOG4108TSC N-acetyltransferase FBF59_08730 ENOG4107S4Y M20 DapE family protein YgeY FBF59_08745 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FBF59_08770 ENOG4105C37 (CBS) domain FBF59_08805 ENOG4105E90 ABC transporter FBF59_08810 ENOG4108IJ8 ABC transporter FBF59_08840 ENOG4108YV3 Protein of unknown function (DUF2711) FBF59_08850 ENOG4105C6Z Gluconate FBF59_08855 ENOG4105CMG Carbohydrate kinase FBF59_08875 ENOG4107ZY0 Phenazine biosynthesis-like protein FBF59_08880 ENOG4106KNT transcriptional regulator FBF59_08885 ENOG4105WH1 Two component transcriptional regulator luxr family FBF59_08890 ENOG4105BZU Histidine kinase FBF59_08895 ENOG4105D8X mechanosensitive ion channel FBF59_08925 ENOG4105F0I Aminotransferase FBF59_08930 ENOG4108MES Periplasmic binding protein FBF59_08935 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FBF59_08950 ENOG4105CAQ asparagine synthetase FBF59_08955 ENOG4107Y70 Heat shock protein FBF59_08960 ENOG4108KF3 Electron transport protein SCO1 SenC FBF59_08970 ENOG4108RCR degv family FBF59_08980 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FBF59_08990 ENOG4108UT2 hemolysin iii FBF59_08995 ENOG4105E9Q Acyl-transferase FBF59_09005 ENOG4107RVG penicillin-binding protein FBF59_09035 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FBF59_09060 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FBF59_09065 ENOG4105VMP Transcriptional regulator FBF59_09075 ENOG4105KD7 acetyltransferase FBF59_09095 ENOG4105CY2 Citrate transporter FBF59_09100 ENOG4107XGZ Hydrolase FBF59_09115 ENOG4108EF6 Proline imino-peptidase FBF59_09125 ENOG4105C5S asparaginyl-tRNA synthetase FBF59_09140 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FBF59_09170 ENOG4105C75 arginyL-tRNA synthetase FBF59_09175 ENOG4107YX5 Pfam:DUF548 FBF59_09200 ENOG4108UUM single-stranded DNA-binding protein FBF59_09215 ENOG4105C5H ABC transporter FBF59_09255 ENOG4105MCT stage V sporulation protein S FBF59_09290 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FBF59_09295 ENOG4108IFG nitrite reductase, (NAD(P)H) FBF59_09300 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FBF59_09305 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FBF59_09310 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FBF59_09315 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FBF59_09340 ENOG4108ZAF Molybdopterin FBF59_09345 ENOG4105CVM Molybdenum cofactor synthesis domain protein FBF59_09350 ENOG4105D06 uba thif-type nad fad binding protein FBF59_09355 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FBF59_09360 ENOG4107V6Q Cyclic nucleotide-binding domain FBF59_09370 ENOG4105R3A Nitrate reductase FBF59_09375 ENOG4108IUE nitrate reductase beta subunit FBF59_09385 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FBF59_09400 ENOG4108V06 Glutathione peroxidase FBF59_09410 ENOG4105CNW domain protein FBF59_09420 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FBF59_09430 ENOG4105EMN RNA polymerase sigma factor FBF59_09435 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FBF59_09445 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FBF59_09450 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FBF59_09470 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FBF59_09495 ENOG4105KBJ sporulation protein ytfj FBF59_09505 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FBF59_09630 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FBF59_09640 ENOG4106PAW secretion accessory protein EsaA YueB FBF59_09660 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FBF59_09690 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FBF59_09695 ENOG4108JYZ YitT family FBF59_09700 ENOG41087PP glycosyltransferase MGT family FBF59_09715 ENOG4107RBS Methyltransferase FBF59_09720 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FBF59_09730 ENOG4105D94 Major Facilitator Superfamily FBF59_09735 ENOG41082F9 transcriptional regulator FBF59_09740 ENOG4108X4Q Hydrolase FBF59_09750 ENOG4108ZRV stage ii sporulation protein p FBF59_09780 ENOG4108VXD carboxy-peptidase FBF59_09790 ENOG4108ZRV stage ii sporulation protein p FBF59_09810 ENOG4108Z7R Chaperone CsaA FBF59_09840 ENOG4105C37 (CBS) domain FBF59_09845 ENOG4105SXS Protein of unknown function (DUF456) FBF59_09865 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FBF59_09875 ENOG4108S4H thioesterase Superfamily protein FBF59_09885 ENOG4108PJD permease FBF59_09900 ENOG4107T5V SNARE associated Golgi FBF59_09920 ENOG4105CVJ phosphoglycerate mutase FBF59_09945 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FBF59_09955 ENOG4105K4T epimerase FBF59_09960 ENOG4105DSE periplasmic solute binding protein FBF59_09970 ENOG4105CKI cobalamin synthesis protein FBF59_09975 ENOG4107QM2 Aldo Keto reductase FBF59_09980 ENOG4105VMI -acetyltransferase FBF59_09995 ENOG4105DEN Luciferase family FBF59_10010 ENOG4108WPJ Ferritin-like domain FBF59_10015 ENOG4108K88 Membrane FBF59_10035 ENOG4105C8Q Methyl-accepting chemotaxis FBF59_10070 ENOG4105CPC Aldo Keto reductase FBF59_10075 ENOG4105YVS arsR family transcriptional regulator FBF59_10085 ENOG4105KRN Transcriptional regulator, abrb family FBF59_10135 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FBF59_10140 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FBF59_10150 ENOG4105YWU small acid-soluble spore protein FBF59_10155 ENOG4108WBH protein TIM barrel FBF59_10170 ENOG4105CEY Amp-dependent synthetase and ligase FBF59_10175 ENOG4105DUU IucA IucC family protein FBF59_10185 ENOG4105VRR gCN5-related N-acetyltransferase FBF59_10190 ENOG4105KT7 mgtC SapB transporter FBF59_10200 ENOG4107VMI polysaccharide deacetylase FBF59_10205 ENOG4108KGH TRANSCRIPTIONal FBF59_10230 ENOG4105D6E homoserine dehydrogenase FBF59_10250 ENOG4108ZJ4 polysaccharide deacetylase FBF59_10255 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FBF59_10275 ENOG4105BZU Histidine kinase FBF59_10280 ENOG4105EFI regulatoR FBF59_10285 ENOG4105BZ1 (ABC) transporter FBF59_10340 ENOG4108UT6 Transferase hexapeptide repeat containing protein FBF59_10350 ENOG4105K64 Glycosyl transferase, family 2 FBF59_10360 ENOG4108JJ8 (ABC) transporter FBF59_10365 ENOG4108JJ9 ABC, transporter FBF59_10370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FBF59_10375 ENOG4105C4M (Ubiquinol oxidase) subunit I FBF59_10405 ENOG4105EGI Transcriptional regulator FBF59_10415 ENOG4105C32 Amino acid ABC transporter (Permease) FBF59_10420 ENOG4108IV0 ABC, transporter FBF59_10425 ENOG4105C0Z ABC transporter FBF59_10435 ENOG4105CKI cobalamin synthesis protein FBF59_10450 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FBF59_10455 ENOG4106F5Q Membrane FBF59_10460 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FBF59_10465 ENOG4108TVJ Nitroreductase FBF59_10470 ENOG4107ZXU DSBA oxidoreductase FBF59_10475 ENOG4108Z40 Transcriptional regulator FBF59_10480 ENOG4105GZI Transcriptional regulator FBF59_10485 ENOG4107RT3 EamA-like transporter family FBF59_10490 ENOG4105KTB nuclear export factor GLE1 FBF59_10495 ENOG4108T5E Copper resistance protein FBF59_10545 ENOG4107R16 Multicopper oxidase FBF59_10555 ENOG4107RAQ aminopeptidase FBF59_10600 ENOG4105KG3 cytidine deaminase FBF59_10605 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FBF59_10610 ENOG4105D9N nucleoside FBF59_10620 ENOG4107RHR regulatoR FBF59_10635 ENOG4105K8R UPF0145 protein FBF59_10645 ENOG410849A acetyltransferase, (GNAT) family FBF59_10680 ENOG4105C0X amino acid FBF59_10685 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FBF59_10700 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FBF59_10720 ENOG41068WN FBF59_10745 ENOG4105CYC Transferase FBF59_10750 ENOG4105DY9 regulatoR FBF59_10765 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FBF59_10770 ENOG4105C6X Major Facilitator FBF59_10795 ENOG4105C7B Threonine dehydratase FBF59_10805 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FBF59_10815 ENOG4105C7K acetolactate synthase FBF59_10820 ENOG4105CM2 brancheD-chain amino acid aminotransferase FBF59_10825 ENOG4105CHR reductase FBF59_10850 ENOG4105H67 Protein of unknown function (DUF421) FBF59_10855 ENOG4105X5K response regulator receiver protein FBF59_10865 ENOG4105C8J )-transporter FBF59_10885 ENOG4105C6T cysteine synthase FBF59_10890 ENOG4105EU0 Major facilitator Superfamily FBF59_10895 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FBF59_10905 ENOG4105DXI Major Facilitator superfamily FBF59_10915 ENOG4105U3E Transcriptional regulator FBF59_10920 ENOG4105CSR polyphosphate kinase 2 FBF59_10935 ENOG4105E09 nadh pyrophosphatase FBF59_10940 ENOG4105FVX FBF59_11000 ENOG4105C6K Malic enzyme FBF59_11005 ENOG4108IJ0 Aspartate ammonia-lyase FBF59_11015 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FBF59_11035 ENOG4105CJ1 ABC, transporter FBF59_11075 ENOG4106BRA Membrane FBF59_11095 ENOG4107JM4 Tetratricopeptide repeat FBF59_11105 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FBF59_11110 ENOG4107QIV Cytochrome c biogenesis protein FBF59_11130 ENOG4105EC3 peptidase S51, dipeptidase E FBF59_11135 ENOG4107QJQ Mate efflux family protein FBF59_11155 ENOG4105C9Q fumarate hydratase class II FBF59_11165 ENOG4105VUF Transcriptional regulator FBF59_11170 ENOG4105DFD Na H antiporter FBF59_11185 ENOG4108PJD permease FBF59_11195 ENOG4105CKI cobalamin synthesis protein FBF59_11215 ENOG4105PGM cation diffusion facilitator family transporter FBF59_11235 ENOG4105CAQ asparagine synthetase FBF59_11245 ENOG4105K56 Transcriptional regulator FBF59_11255 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FBF59_11265 ENOG4105CVJ phosphoglycerate mutase FBF59_11300 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FBF59_11305 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FBF59_11315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FBF59_11320 ENOG4105DUM transcriptional regulator, lysR family FBF59_11345 ENOG4107QZ7 Cellulose synthase catalytic subunit FBF59_11350 ENOG4105KAC Antibiotic biosynthesis monooxygenase FBF59_11380 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FBF59_11385 ENOG4105CPU Monooxygenase FBF59_11390 ENOG4105KTQ flagellar basal-body rod protein FBF59_11395 ENOG4105FZW flagellar biosynthesis regulator FlhF FBF59_11400 ENOG4105D7B Flagellar biosynthesis protein flha FBF59_11405 ENOG4105D00 flagellar biosynthetic protein flhB FBF59_11415 ENOG4105VS8 Flagellar biosynthetic protein fliq FBF59_11420 ENOG4105CN7 Flagellar biosynthetic protein FliP FBF59_11430 ENOG4105DD5 Flagellar motor switch protein FBF59_11435 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FBF59_11445 ENOG4105E4C Lytic transglycosylase catalytic FBF59_11450 ENOG4105I03 Flagellin FBF59_11480 ENOG4107R88 Chemotaxis protein (CheV) FBF59_11495 ENOG4105BZE flagellar hook protein, FlgE FBF59_11525 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FBF59_11530 ENOG4107U2N Flagellar M-ring protein FBF59_11535 ENOG41075Z6 flagellar hook-basal body complex protein fliE FBF59_11540 ENOG4108ZC9 flagellar basal-body rod protein flgc FBF59_11545 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FBF59_11565 ENOG4105DTJ flagellar hook-associated protein FBF59_11570 ENOG4105E1Q flagellar hook-associated protein FBF59_11590 ENOG4105BZU Histidine kinase FBF59_11605 ENOG4105DD5 Flagellar motor switch protein FBF59_11610 ENOG4105CBS Chea signal transduction histidine kinase FBF59_11615 ENOG4107YTP response regulator receiver protein FBF59_11620 ENOG4105ER2 Ompa motb domain protein FBF59_11625 ENOG4107R0U MotA TolQ exbB proton channel FBF59_11635 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FBF59_11675 ENOG41080C8 DUF218 domain FBF59_11680 ENOG4105H67 Protein of unknown function (DUF421) FBF59_11690 ENOG4108Z5V transcriptional regulator, merr family FBF59_11700 ENOG4107RWR Sodium hydrogen exchanger FBF59_11710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FBF59_11775 ENOG41081VK Ribonuclease FBF59_11795 ENOG4108SZE gCN5-related N-acetyltransferase FBF59_11810 ENOG4105CPK Glycosyl transferase (Group 1 FBF59_11840 ENOG4105HTX biosynthesis protein FBF59_11875 ENOG4106032 Glutathionylspermidine synthase FBF59_11900 ENOG4105KHC sulfurtransferase FBF59_11910 ENOG4108W0I acetyltransferase FBF59_11920 ENOG410890F Dynamin family FBF59_11925 ENOG4105DHF Membrane FBF59_11930 ENOG4105C2W permease FBF59_11940 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FBF59_11955 ENOG4105CTD carboxy-peptidase FBF59_11960 ENOG4105DVT helicase FBF59_11970 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FBF59_12025 ENOG4105BZ4 penicillin-binding protein FBF59_12035 ENOG4105CSM endonuclease III FBF59_12055 ENOG4105YAC FBF59_12060 ENOG4105DVT helicase FBF59_12095 ENOG4105CPK Glycosyl transferase (Group 1 FBF59_12100 ENOG4105FJR Lmbe family FBF59_12115 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FBF59_12120 ENOG4108JYZ YitT family FBF59_12155 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FBF59_12160 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FBF59_12175 ENOG41068YB TPR repeat-containing protein FBF59_12195 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FBF59_12200 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FBF59_12205 ENOG4105EAH synthase FBF59_12215 ENOG4105XXQ heptaprenyl diphosphate synthase component I FBF59_12230 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FBF59_12260 ENOG41065D1 FBF59_12265 ENOG4105S2F FBF59_12295 ENOG4107RB3 L-asparaginase FBF59_12300 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FBF59_12325 ENOG4108S6Z Negative regulator of genetic competence FBF59_12330 ENOG4108XDN Transcriptional regulator FBF59_12335 ENOG4107RGJ metallophosphoesterase FBF59_12345 ENOG4105I7S Abortive infection protein FBF59_12350 ENOG4105C9U ATP-dependent DNA helicase RecQ FBF59_12365 ENOG4108SAX Membrane FBF59_12375 ENOG41063SB peptidase FBF59_12380 ENOG4108WBT adenosyltransferase FBF59_12385 ENOG4105BZU Histidine kinase FBF59_12390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_12395 ENOG4105CRE cytochrome C FBF59_12400 ENOG4107TWT Cytochrome c biogenesis protein FBF59_12405 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FBF59_12410 ENOG4105FE9 pseudouridine synthase FBF59_12420 ENOG4108JIC nucleoside recognition domain protein FBF59_12425 ENOG4105DZ1 carboxypeptidase FBF59_12430 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FBF59_12460 ENOG4105BZU Histidine kinase FBF59_12475 ENOG4105I3N Conserved Protein FBF59_12480 ENOG4105BZU Histidine kinase FBF59_12495 ENOG4105BZ4 penicillin-binding protein FBF59_12500 ENOG4107GRR phosphate transport regulator FBF59_12505 ENOG4105CJ3 phosphate transporter FBF59_12525 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FBF59_12550 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FBF59_12570 ENOG4105WH1 Two component transcriptional regulator luxr family FBF59_12595 ENOG4105DFD Na H antiporter FBF59_12615 ENOG4105C8J )-transporter FBF59_12620 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FBF59_12625 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FBF59_12630 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FBF59_12640 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FBF59_12645 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FBF59_12665 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FBF59_12675 ENOG4105E0M Sulfatase FBF59_12680 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FBF59_12695 ENOG4107RVV histidinol phosphate phosphatase, hisj family FBF59_12730 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FBF59_12765 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FBF59_12770 ENOG4108ZP8 Acetolactate synthase small subunit FBF59_12775 ENOG4105C7K acetolactate synthase FBF59_12780 ENOG4105CM2 brancheD-chain amino acid aminotransferase FBF59_12805 ENOG41063Y9 FBF59_12810 ENOG4105CZN Potassium uptake protein FBF59_12840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FBF59_12870 ENOG4105NQC Flavodoxin FBF59_12890 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FBF59_12900 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FBF59_12905 ENOG4105EA8 2-Nitropropane dioxygenase FBF59_12910 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FBF59_12950 ENOG4105CJ1 ABC, transporter FBF59_12960 ENOG4105CZV ABC transporter FBF59_12965 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FBF59_12970 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FBF59_12975 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FBF59_12980 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FBF59_13020 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FBF59_13025 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FBF59_13035 ENOG4105BZU Histidine kinase FBF59_13040 ENOG4106DF1 FBF59_13050 ENOG41090MY MarR family Transcriptional regulator FBF59_13055 ENOG4105BZU Histidine kinase FBF59_13065 ENOG4105PXI polysaccharide deacetylase FBF59_13075 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FBF59_13085 ENOG4105E98 transcriptional regulator DeoR family FBF59_13105 ENOG4107RCV ABC transporter, permease FBF59_13110 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FBF59_13115 ENOG4105C4Y ABC transporter FBF59_13145 ENOG4105CHR reductase FBF59_13165 ENOG4108Z7G MaoC domain protein dehydratase FBF59_13170 ENOG410681C small acid-soluble spore protein FBF59_13175 ENOG4105CZN Potassium uptake protein FBF59_13180 ENOG4107TS3 membrane protein, TerC FBF59_13185 ENOG4108QTI )-transporter FBF59_13195 ENOG4106A3R peptidase FBF59_13215 ENOG4105JXH GntR family transcriptional regulator FBF59_13220 ENOG4105BZU Histidine kinase FBF59_13225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_13240 ENOG4105CQB FAD linked oxidase domain protein FBF59_13245 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FBF59_13250 ENOG4105K4I Scp-like extracellular FBF59_13260 ENOG4108YBP pseudouridine synthase FBF59_13270 ENOG4105EYF MMPL domain protein FBF59_13275 ENOG410841Q phosphoesterase PA-phosphatase related protein FBF59_13280 ENOG4107RUE extracellular solute-binding protein family 1 FBF59_13285 ENOG4105D38 putrescine abc transporter FBF59_13290 ENOG4105F38 ABC transporter, permease FBF59_13295 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FBF59_13300 ENOG4105C26 Dehydrogenase FBF59_13335 ENOG4105VFR signal peptidase FBF59_13340 ENOG4105DZ1 carboxypeptidase FBF59_13350 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FBF59_13375 ENOG4105RHA ABC transporter, permease FBF59_13380 ENOG4108IUX (ABC) transporter FBF59_13415 ENOG4105VZ8 Transcriptional regulator FBF59_13425 ENOG4105C7S Dehydrogenase FBF59_13520 ENOG4105DDQ anthranilate synthase FBF59_13525 ENOG4105CRQ synthase (Component I) FBF59_13535 ENOG4105CK7 Sodium proline symporter FBF59_13610 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FBF59_13620 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FBF59_13625 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FBF59_13665 ENOG4105K64 Glycosyl transferase, family 2 FBF59_13685 ENOG4105EMS pseudouridine synthase FBF59_13690 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FBF59_13705 ENOG4105MIX Adenylate cyclase FBF59_13710 ENOG4108Z18 K06886 hemoglobin FBF59_13720 ENOG4105DPN Oligoendopeptidase f FBF59_13730 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FBF59_13740 ENOG4108ZCF integral membrane protein FBF59_13765 ENOG4105UQX Mate efflux family protein FBF59_13770 ENOG4108JQ7 (ABC) transporter FBF59_13780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FBF59_13785 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FBF59_13810 ENOG4105C31 Tryptophanyl-tRNA synthetase FBF59_13825 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FBF59_13830 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FBF59_13855 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FBF59_13865 ENOG4108KP7 hydrolase FBF59_13875 ENOG41073B9 FBF59_13880 ENOG4107AYK membrAne FBF59_13890 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FBF59_13940 ENOG4105CNA YD repeat protein FBF59_13945 ENOG4105QNR S1 RNA binding domain protein FBF59_13970 ENOG4105BZU Histidine kinase FBF59_13975 ENOG4105CH6 catalase FBF59_13980 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FBF59_13985 ENOG4105CAQ asparagine synthetase FBF59_14005 ENOG4105C8Y Acetylornithine aminotransferase FBF59_14015 ENOG4105ERH Fumarylacetoacetate hydrolase FBF59_14080 ENOG4105XVF Competence transcription factor FBF59_14095 ENOG4105VEQ Cold shock protein FBF59_14115 ENOG4107QP3 malate synthase g FBF59_14125 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FBF59_14135 ENOG4105C8Q Methyl-accepting chemotaxis FBF59_14140 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FBF59_14160 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FBF59_14180 ENOG41086D8 Transcriptional regulator FBF59_14190 ENOG4108AEY RNA polymerase sigma factor FBF59_14200 ENOG4107TVP HD domain protein FBF59_14205 ENOG4107RN3 metallophosphoesterase FBF59_14210 ENOG4105ENX hydrolase FBF59_14220 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FBF59_14270 ENOG4105CEY Amp-dependent synthetase and ligase FBF59_14280 ENOG4105DF9 Lipoate-protein, ligase FBF59_14285 ENOG4108RQ5 Beta-lactamase domain-containing protein FBF59_14290 ENOG4106AXD FBF59_14320 ENOG4105ECB domain protein FBF59_14350 ENOG4105C1Q protoporphyrinogen oxidase FBF59_14355 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FBF59_14365 ENOG4105BZ4 penicillin-binding protein FBF59_14370 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FBF59_14380 ENOG410905X membrane-flanked domain protein FBF59_14420 ENOG4105CKV Membrane FBF59_14425 ENOG410905X membrane-flanked domain protein FBF59_14455 ENOG4105K59 histidine triad (HIT) protein FBF59_14485 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FBF59_14490 ENOG4105EEM helicase FBF59_14520 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FBF59_14535 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FBF59_14540 ENOG4105D7V transposase FBF59_14545 ENOG41067QW Transcriptional regulator FBF59_14550 ENOG4105F0F Oxalate decarboxylase FBF59_14575 ENOG4108MUZ hydrolase FBF59_14600 ENOG410829K Lysine exporter protein (Lyse ygga) FBF59_14615 ENOG4106D4I domain protein FBF59_14620 ENOG4107VRP DNA repair exonuclease FBF59_14640 ENOG4107QHE Choloylglycine hydrolase FBF59_14650 ENOG4105D7V transposase FBF59_14680 ENOG4105BZU Histidine kinase FBF59_14685 ENOG4105BZU Histidine kinase FBF59_14690 ENOG4108MJI response regulator FBF59_14700 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FBF59_14710 ENOG4105WN5 stage II sporulation protein FBF59_14835 ENOG4105CMT Dihydroxyacetone kinase FBF59_14850 ENOG4105CMT Dihydroxyacetone kinase FBF59_14865 ENOG4105WAB arsR family transcriptional regulator FBF59_14870 ENOG4105F27 Major Facilitator FBF59_14880 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FBF59_14945 ENOG4105F6J Alpha beta hydrolase fold FBF59_15030 ENOG4105C0R drug resistance transporter emrb qaca subfamily FBF59_15060 ENOG4105CDU Replicative dna helicase FBF59_15080 ENOG4105C4R Atp-dependent dna helicase FBF59_15125 ENOG4108MRH transcriptional regulatory protein FBF59_15135 ENOG4105CSH Transporter FBF59_15190 ENOG4105GMB type VI secretion system effector, hcp1 family FBF59_15250 ENOG4107SFI Major Facilitator superfamily FBF59_15255 ENOG4105D06 uba thif-type nad fad binding protein FBF59_15270 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FBF59_15300 ENOG4108JQ7 (ABC) transporter FBF59_15310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FBF59_15325 ENOG4105CIF Ornithine Cyclodeaminase FBF59_15350 ENOG4105DER m42 family FBF59_15370 ENOG4105CGU Enoyl-CoA hydratase FBF59_15395 ENOG4105CHH sulfate transporter FBF59_15405 ENOG4105CEY Amp-dependent synthetase and ligase FBF59_15410 ENOG4105D4P Coproporphyrinogen iii oxidase FBF59_15415 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FBF59_15420 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein FBF59_15440 ENOG4107FQX Alpha-acetolactate decarboxylase FBF59_15475 ENOG410839P FBF59_15490 ENOG4105CDA abc transporter atp-binding protein FBF59_15495 ENOG4105DRP amino acid AbC transporter FBF59_15510 ENOG4105BZ1 (ABC) transporter FBF59_15515 ENOG4105BZ1 (ABC) transporter FBF59_15525 ENOG4105C26 Dehydrogenase FBF59_15530 ENOG4105D5Q Arginine ornithine antiporter FBF59_15540 ENOG4105CH6 catalase FBF59_15545 ENOG4107RKG DJ-1/PfpI family FBF59_15585 ENOG4105KPY Small multidrug resistance protein FBF59_15590 ENOG4105W1Y Transcriptional regulator FBF59_15595 ENOG4105UBK short-chain dehydrogenase reductase FBF59_15605 ENOG4108YXU transcriptional regulator AsnC family FBF59_15645 ENOG4106KNT transcriptional regulator FBF59_15655 ENOG4107RWR Sodium hydrogen exchanger FBF59_15660 ENOG4105CUB amino acid FBF59_15690 ENOG4107T5V SNARE associated Golgi FBF59_15725 ENOG4105WEF catalase FBF59_15755 ENOG4105C19 ABC transporter FBF59_15760 ENOG4107RBB ABC transporter, permease FBF59_15765 ENOG41069ER domain protein FBF59_15790 ENOG4105VZJ PTS System FBF59_15795 ENOG4105VCP PTS System FBF59_15800 ENOG4105EMD TRANSCRIPTIONal FBF59_15830 ENOG4108KGH TRANSCRIPTIONal FBF59_15840 ENOG41087NI Sulfite exporter TauE/SafE FBF59_15845 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FBF59_15855 ENOG4105VFE sira family FBF59_15860 ENOG4105VFE sira family FBF59_15865 ENOG4107TPS domain protein FBF59_15870 ENOG4105VFE sira family FBF59_15875 ENOG4105XTG Pfam:DUF156 FBF59_15895 ENOG4105ED1 spovr family FBF59_15900 ENOG4107Y03 Nitroreductase FBF59_15920 ENOG4108B31 Spore germination protein FBF59_15940 ENOG4105K63 Thioredoxin FBF59_15955 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FBF59_15965 ENOG4105C7N Xanthine uracil vitamin C permease FBF59_15980 ENOG4108INS Transcriptional regulator FBF59_16030 ENOG4105DWF phosphomethylpyrimidine kinase FBF59_16035 ENOG4105D06 uba thif-type nad fad binding protein FBF59_16050 ENOG41080HI glycine oxidase FBF59_16055 ENOG4108VEU Thiamine monophosphate synthase FBF59_16065 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FBF59_16075 ENOG4105ETU transcriptional activator (TenA FBF59_16095 ENOG41080XQ Signal transduction protein with cbs domains FBF59_16225 ENOG4105E2Z phosphate ABC transporter (Permease FBF59_16230 ENOG4105C8U phosphate abc transporter FBF59_16235 ENOG4105CVA phosphate FBF59_16245 ENOG4105CE1 Ferrous iron transport protein b FBF59_16250 ENOG4105CE1 Ferrous iron transport protein b FBF59_16255 ENOG4108NHD germination protein FBF59_16270 ENOG4105E1V na solute symporter FBF59_16275 ENOG4106CAD Protein of unknown function (DUF3311) FBF59_16295 ENOG4105E2S oxidase) subunit II FBF59_16300 ENOG4105BZ9 Cytochrome C oxidase, subunit I FBF59_16325 ENOG4105MA6 gCN5-related N-acetyltransferase FBF59_16340 ENOG4105C7N Xanthine uracil vitamin C permease FBF59_16345 ENOG4105C85 amino acid FBF59_16365 ENOG4105DUX Transporter FBF59_16380 ENOG4107D63 FBF59_16385 ENOG4105VZ8 Transcriptional regulator FBF59_16390 ENOG41069ER domain protein FBF59_16395 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FBF59_16400 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FBF59_16430 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FBF59_16470 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FBF59_16475 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FBF59_16480 ENOG4105CNN ABC, transporter FBF59_16485 ENOG4105C2J ABC transporter FBF59_16495 ENOG4108RVA ribokinase FBF59_16500 ENOG4105ETE Transcriptional regulator (LacI family FBF59_16505 ENOG4105C0R drug resistance transporter emrb qaca subfamily FBF59_16510 ENOG41067TZ transcriptional regulator, MarR family FBF59_16515 ENOG4105CXY transporter FBF59_16525 ENOG41068KF Universal stress protein FBF59_16530 ENOG4105CHH sulfate transporter FBF59_16555 ENOG4105BZU Histidine kinase FBF59_16560 ENOG4105NAE bifunctional deaminase-reductase domain protein FBF59_16565 ENOG4105D29 Helix-turn-helix type 11 domain protein FBF59_16575 ENOG4105GFR rna polymerase sigma factor FBF59_16590 ENOG4108IQI permease FBF59_16595 ENOG4105DRP amino acid AbC transporter FBF59_16600 ENOG4105EAD ABC transporter FBF59_16605 ENOG4105CT1 (ABC) transporter FBF59_16610 ENOG4105CDA abc transporter atp-binding protein FBF59_16620 ENOG4105BZG amino acid carrier protein FBF59_16625 ENOG4105CRN Aminoglycoside phosphotransferase FBF59_16630 ENOG4105E1K spore germination protein FBF59_16645 ENOG4105CG3 alpha amylase, catalytic region FBF59_16650 ENOG4105C5Y PTS System FBF59_16655 ENOG4107414 GntR family transcriptional regulator FBF59_16660 ENOG4105D5Q Arginine ornithine antiporter FBF59_16665 ENOG4105BZU Histidine kinase FBF59_16675 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FBF59_16680 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FBF59_16685 ENOG4107T89 von Willebrand factor, type A FBF59_16695 ENOG4105EXW epimerase dehydratase FBF59_16710 ENOG4105E0A ABC, transporter FBF59_16715 ENOG4108IHU transport system permease protein FBF59_16720 ENOG4105DQ5 transport system permease protein FBF59_16725 ENOG4108MES Periplasmic binding protein FBF59_16730 ENOG4105DUX Transporter FBF59_16745 ENOG4105DAA L-lactate FBF59_16750 ENOG4108IJ0 Aspartate ammonia-lyase FBF59_16755 ENOG4105C37 (CBS) domain FBF59_16760 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FBF59_16765 ENOG4105D9N nucleoside FBF59_16770 ENOG4108KGH TRANSCRIPTIONal FBF59_16775 ENOG41073R8 VanW family FBF59_16810 ENOG4105DAP Nicotinate phosphoribosyltransferase FBF59_16815 ENOG4105C59 p-type ATPase FBF59_16825 ENOG4105CUB amino acid FBF59_16845 ENOG4108JB9 formate dehydrogenase FBF59_16850 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FBF59_16875 ENOG4105BZU Histidine kinase FBF59_16885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FBF59_16890 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FBF59_16895 ENOG4108UZ3 Transporter FBF59_16905 ENOG4105C6K Malic enzyme FBF59_16915 ENOG4108MRH transcriptional regulatory protein FBF59_16940 ENOG4105US7 Histidine kinase FBF59_16945 ENOG4108STX response regulator FBF59_16950 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FBF59_16955 ENOG4105BZ7 extracellular solute-binding protein family 1 FBF59_16960 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FBF59_16965 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FBF59_16970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FBF59_16975 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FBF59_17000 ENOG4105D4T Citrate transporter FBF59_17005 ENOG4108V9W transcriptional regulatory protein FBF59_17010 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FBF59_17020 ENOG4105DZ6 Band 7 protein FBF59_17035 ENOG4105C94 Transporter FBF59_17050 ENOG4105CYN Serine protein kinase FBF59_17055 ENOG4105BZU Histidine kinase FBF59_17060 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FBF59_17070 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FBF59_17080 ENOG4108R9S DSBA oxidoreductase FBF59_17085 ENOG4108JQC penicillin-binding protein 1A FBF59_17205 ENOG4105G5W regulator Fur family FBF59_17210 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FBF59_17230 ENOG4108IUW ABC transporter FBF59_17240 ENOG4105CBC glutamate synthase FBF59_17245 ENOG4107NBY Membrane FBF59_17250 ENOG4105BZ1 (ABC) transporter FBF59_17270 ENOG4106BXE FBF59_17275 ENOG4105CEN a g-specific adenine glycosylase FBF59_17280 ENOG41067AE Membrane-bound metal-dependent hydrolase FBF59_17310 ENOG4105ECP epimerase FBF59_17315 ENOG4105CI2 imidazolone-5-propionate hydrolase FBF59_17335 ENOG4105F1A Pyruvate formate-lyase FBF59_17350 ENOG4105CKK Glycosyl transferase, family 2 FBF59_17355 ENOG4105C3I Nad-dependent epimerase dehydratase FBF59_17360 ENOG4107QQG Dehydrogenase FBF59_17365 ENOG4105CKK Glycosyl transferase, family 2 FBF59_17380 ENOG4108A04 Beta-lactamase FBF59_17400 ENOG4105CSV Glutaminase FBF59_17425 ENOG4108IQI permease FBF59_17435 ENOG4108JUB Transcriptional regulator FBF59_17445 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FBF59_17460 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FBF59_17495 ENOG4105UPD Calcium Proton FBF59_17500 ENOG410606W general stress protein FBF59_17515 ENOG4107ZTW SNARE associated Golgi FBF59_17535 ENOG4108IPJ Membrane FBF59_17540 ENOG4105C59 p-type ATPase FBF59_17545 ENOG4107U9T Pfam:Ribonuclease_BN FBF59_17555 ENOG4105KJF protein tyrosine phosphatase FBF59_17560 ENOG41068PA UPF0435 protein FBF59_17575 ENOG4108TTB tellurium resistance protein FBF59_17580 ENOG4107TS3 membrane protein, TerC FBF59_17585 ENOG4106FN3 tellurium resistance protein FBF59_17590 ENOG4106FN3 tellurium resistance protein FBF59_17595 ENOG4108N0M stress protein FBF59_17625 ENOG4105DEU major facilitator superfamily FBF59_17640 ENOG41062JF Transcriptional regulator FBF59_17675 ENOG4105C5H ABC transporter FBF59_17685 ENOG4105D2X ABC transporter substrate-binding protein FBF59_17690 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FBF59_17710 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FBF59_17725 ENOG4105C9U ATP-dependent DNA helicase RecQ FBF59_17740 ENOG4105CI1 PTS System FBF59_17750 ENOG4105DNP FAD linked oxidase domain protein FBF59_17760 ENOG4108W63 CRP FNR family transcriptional regulator FBF59_17765 ENOG4105C5B carbamate kinase FBF59_17775 ENOG4105DBV ornithine carbamoyltransferase FBF59_17790 ENOG4105C8Q Methyl-accepting chemotaxis FBF59_17795 ENOG4105CDA abc transporter atp-binding protein FBF59_17800 ENOG4105EAB amino acid AbC transporter FBF59_17805 ENOG4105E5Q amino acid AbC transporter FBF59_17820 ENOG4105D2S major facilitator superfamily FBF59_17825 ENOG410756H nucleotidyltransferase FBF59_17845 ENOG4105BZU Histidine kinase FBF59_17860 ENOG4106UIA FBF59_17865 ENOG4106UIA FBF59_17895 ENOG4108V5C ABC transporter FBF59_17900 ENOG4105DQ5 transport system permease protein FBF59_17905 ENOG4105EHG Permease protein FBF59_17915 ENOG4107W7X Aldolase FBF59_17920 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FBF59_17925 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FBF59_17930 ENOG4105D3R alkyl hydroperoxide reductase FBF59_17950 ENOG4105DFD Na H antiporter FBF59_17960 ENOG4105DTQ mandelate racemase muconate lactonizing FBF59_17980 ENOG4108W15 Protein of unknown function (DUF1456) FBF59_17990 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FBF59_17995 ENOG4105D9N nucleoside FBF59_18020 ENOG4105KPY Small multidrug resistance protein FBF59_18025 ENOG4105C26 Dehydrogenase FBF59_18035 ENOG4108JPW Aminotransferase FBF59_18045 ENOG4105CBD Diacylglycerol kinase FBF59_18065 ENOG4107I77 yiaA/B two helix domain FBF59_18070 ENOG410834F Transcriptional regulator FBF59_18090 ENOG4105D01 (LipO)protein FBF59_18095 ENOG4108UMI ABC transporter, permease FBF59_18100 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FBF59_18110 ENOG4108W2Y isochorismatase FBF59_18135 ENOG4105C4R Atp-dependent dna helicase FBF59_18160 ENOG4105C12 Phosphoribosylglycinamide synthetase FBF59_18170 ENOG4108V3E phosphoribosylglycinamide formyltransferase FBF59_18195 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FBF59_18205 ENOG4105C83 adenylosuccinate lyase FBF59_18210 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FBF59_18215 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FBF59_18240 ENOG410631K Membrane FBF59_18260 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FBF59_18310 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FBF59_18330 ENOG4107ZXU DSBA oxidoreductase FBF59_18360 ENOG4105BZU Histidine kinase FBF59_18370 ENOG4105C7N Xanthine uracil vitamin C permease FBF59_18380 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FBF59_18395 ENOG4106128 DNA-binding helix-turn-helix protein FBF59_18405 ENOG4106BHR ftsk SpoIIIE family protein FBF59_18445 ENOG4108IBT Inherit from COG: transposase FBF59_18525 ENOG4108TYN CAAX amino terminal protease family protein FBF59_18540 ENOG4105C5H ABC transporter FBF59_18545 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FBF59_18550 ENOG410801F ribosomal-protein-alanine acetyltransferase FBF59_18555 ENOG41072GX Peptidase M22 Glycoprotease FBF59_18560 ENOG4105K8N protein family UPF0079, ATPase FBF59_18665 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FBF59_18675 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FBF59_18680 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FBF59_18705 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FBF59_18710 ENOG4105CPF Cell wall formation (By similarity) FBF59_18715 ENOG4108SC4 )-transporter FBF59_18720 ENOG4105CUB amino acid FBF59_18730 ENOG4105ERH Fumarylacetoacetate hydrolase FBF59_18735 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FBF59_18760 ENOG410667J hydrolase FBF59_18765 ENOG4108JQ7 (ABC) transporter FBF59_18770 ENOG4105C3U ABC transporter FBF59_18775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FBF59_18785 ENOG4105DEF Extracellular solute-binding protein, family 5 FBF59_18800 ENOG4105C5H ABC transporter FBF59_18820 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FBF59_18835 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FBF59_18855 ENOG4105F6E Acyl-transferase FBF59_18885 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FBF59_18890 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FBF59_18895 ENOG4105E0C molybdate abc transporter FBF59_18920 ENOG4108J59 Extracellular solute-binding protein, family 5 FBF59_18940 ENOG4108JQ7 (ABC) transporter FBF59_18945 ENOG4105C3U ABC transporter FBF59_18950 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FBF59_18955 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FBF59_18975 ENOG4105C2C drug resistance transporter, Bcr CflA FBF59_18990 ENOG4105IQ5 FAD linked oxidase domain protein FBF59_19000 ENOG4105CB2 alcohol dehydrogenase FBF59_19005 ENOG4105D01 (LipO)protein FBF59_19010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FBF59_19015 ENOG4108UMI ABC transporter, permease FBF59_19020 ENOG4108PSK reductase FBF59_19040 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FBF59_19055 ENOG4107U5W ybbr family FBF59_19060 ENOG4105C8B TIGR00159 family FBF59_19140 ENOG4108NMV polysaccharide deacetylase FBF59_19155 ENOG4105D1F ATP-binding protein FBF59_19180 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FBF59_19185 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FBF59_19190 ENOG4108JJB ABC transporter FBF59_19195 ENOG4108JJB ABC transporter FBF59_19220 ENOG41067V7 50S ribosomal protein L36 FBF59_19230 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FBF59_19240 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FBF59_19265 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FBF59_19375 ENOG4105XPM ribosomal protein FBF59_19380 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FBF59_19390 ENOG4107Y49 methyltransferase FBF59_19415 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FBF59_19430 ENOG4105QIV RNA polymerase FBF59_19435 ENOG4105M0M Tetracycline resistance protein FBF59_19440 ENOG4105C2N RNA methyltransferase TrmH family group 3 FBF59_19455 ENOG4105D7W serine acetyltransferase FBF59_19475 ENOG4105CTP PilT protein domain protein FBF59_19485 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FBF59_19500 ENOG4108Z0C Uvrb UvrC protein FBF59_19590 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FBF59_19600 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FBF59_19605 ENOG4105KRF dihydroneopterin aldolase FBF59_19610 ENOG4105EEI dihydropteroate synthase FBF59_19615 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FBF59_19620 ENOG4105DDQ anthranilate synthase FBF59_19625 ENOG4105CRQ synthase (Component I) FBF59_19630 ENOG4105C6T cysteine synthase FBF59_19645 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FBF59_19650 ENOG4108UGV hypoxanthine phosphoribosyltransferase FBF59_19655 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FBF59_19675 ENOG41060GV RNA binding s1 domain protein FBF59_19690 ENOG4105VYY sporulation protein yabp FBF59_19695 ENOG41082I2 s4 domain protein FBF59_19700 ENOG4108IY2 MazG family FBF59_19710 ENOG4108M14 stage v sporulation protein t FBF59_19715 ENOG4108JA2 transcriptioN-repair coupling factor FBF59_19725 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FBF59_19730 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FBF59_19745 ENOG4105KME endoribonuclease L-psp FBF59_19750 ENOG4105DFT pur operon repressor FBF59_19765 ENOG4105W42 Veg protein FBF59_19770 ENOG4105XFA sporulation peptidase YabG FBF59_19780 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FBF59_19785 ENOG4105F8V Hydrolase, tatD family FBF59_19790 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FBF59_19795 ENOG4105KRN Transcriptional regulator, abrb family FBF59_19800 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FBF59_19810 ENOG41060K3 Methyltransferase FBF59_19820 ENOG4105MA4 psp1 domain protein FBF59_19825 ENOG4105FA2 dna polymerase iii FBF59_19835 ENOG4105CXN decarboxylase FBF59_19870 ENOG41067KS pro-sigma K processing FBF59_19890 ENOG4105C6E dna polymerase iii FBF59_19900 ENOG4108Z6B deaminase FBF59_19910 ENOG4105GTG Isochorismatase FBF59_19920 ENOG4105ZMH deoxynucleoside kinase FBF59_19955 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FBF59_19990 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FBF59_20005 ENOG410848D S4 domain protein YaaA FBF59_20010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FBF59_20030 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FBF59_20040 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FBF59_20060 ENOG4107QJE Chromosome Partitioning Protein FBF59_20065 ENOG4105FA0 parb-like partition protein FBF59_20070 ENOG4108ZDA Sporulation protein YyaC FBF59_20075 ENOG4105D8X mechanosensitive ion channel FBF59_20080 ENOG4105VDK protein, conserved in bacteria FBF59_20085 ENOG4105C3G gtp-binding protein FBF59_20095 ENOG4108UUM single-stranded DNA-binding protein FBF59_20105 ENOG4108XMW Membrane FBF59_20110 ENOG4105BZR domain protein FBF59_20120 ENOG4105CDU Replicative dna helicase FBF59_20125 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FBF59_20150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_20155 ENOG4105BZU Histidine kinase FBF59_20170 ENOG4105Q2H domain protein FBF59_20175 ENOG4105C0H protease FBF59_20190 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FBF59_20235 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FBF59_20240 ENOG4107Y5K Resolvase FBF59_20285 ENOG4107Y5K Resolvase FBF59_20305 ENOG4105DPN Oligoendopeptidase f FBF59_20310 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FBF59_20315 ENOG4105C1J atp-dependent rna helicase FBF59_20325 ENOG4108UT2 hemolysin iii FBF59_20330 ENOG4105CMR udp-glucose 4-epimerase FBF59_20345 ENOG4105IW1 AmiS UreI transporter FBF59_20355 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FBF59_20375 ENOG4107RGD Major Facilitator superfamily FBF59_20380 ENOG4108HRK Histidine kinase FBF59_20385 ENOG4108NEV two component transcriptional regulator, LytTR family FBF59_20400 ENOG4106F5Q Membrane FBF59_20405 ENOG4105E0X reductase FBF59_20415 ENOG41067SE Tetr family transcriptional regulator FBF59_20420 ENOG4105C5H ABC transporter FBF59_20425 ENOG4108IG5 Transcriptional regulator FBF59_20435 ENOG4105CKK Glycosyl transferase, family 2 FBF59_20440 ENOG4105EJV Membrane FBF59_20450 ENOG4105K64 Glycosyl transferase, family 2 FBF59_20465 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FBF59_20470 ENOG4108S4H thioesterase Superfamily protein FBF59_20480 ENOG4106YBV Methyl-accepting chemotaxis FBF59_20485 ENOG4105EN6 Membrane FBF59_20495 ENOG4105CG5 Glycosyl transferase (Group 1 FBF59_20510 ENOG41079KZ Major Facilitator Superfamily FBF59_20515 ENOG4105DY9 regulatoR FBF59_20520 ENOG4105D22 carbon starvation protein FBF59_20525 ENOG4105VCD cytoplasmic protein FBF59_20535 ENOG4105BZU Histidine kinase FBF59_20540 ENOG4105DWF phosphomethylpyrimidine kinase FBF59_20545 ENOG4105BZU Histidine kinase FBF59_20550 ENOG4105WH1 Two component transcriptional regulator luxr family FBF59_20560 ENOG4108Y4K DNA-binding transcriptional activator FBF59_20580 ENOG4105D6E homoserine dehydrogenase FBF59_20595 ENOG41090WU lipolytic protein G-D-S-L family FBF59_20600 ENOG4105CJ1 ABC, transporter FBF59_20605 ENOG4108TU7 Inherit from COG: (ABC) transporter FBF59_20615 ENOG4105VCH membrane FBF59_20620 ENOG410667J hydrolase FBF59_20630 ENOG4107SVH Potassium channel protein FBF59_20650 ENOG4108VKI Cell wall hydrolase FBF59_20665 ENOG4107UEZ chlorite dismutase FBF59_20670 ENOG4108IJ2 phosphate acetyltransferase FBF59_20675 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FBF59_20680 ENOG4108VCI transcription factor, rsfa family FBF59_20690 ENOG4105DQ5 transport system permease protein FBF59_20695 ENOG4105EHG Permease protein FBF59_20700 ENOG4105E0A ABC, transporter FBF59_20705 ENOG4108MES Periplasmic binding protein FBF59_20710 ENOG4105DCI Phosphohydrolase FBF59_20715 ENOG41069HH 4-oxalocrotonate tautomerase FBF59_20720 ENOG4108Z4T Peptidase M50 FBF59_20725 ENOG4108XFG YwhD family FBF59_20730 ENOG4105BZ4 penicillin-binding protein FBF59_20735 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FBF59_20740 ENOG4107SWG transcriptional regulator MERR family FBF59_20745 ENOG4105DXB Major Facilitator superfamily FBF59_20755 ENOG4105CYW agmatinase FBF59_20775 ENOG410684U Domain of unknown function (DUF1934) FBF59_20785 ENOG4105EMN RNA polymerase sigma factor FBF59_20805 ENOG4105IIU Aminopeptidase FBF59_20815 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FBF59_20820 ENOG4108M15 ABC transporter FBF59_20825 ENOG4105KCT ABC transporter FBF59_20830 ENOG4105BZU Histidine kinase FBF59_20840 ENOG4105D4Y metalloprotease FBF59_20855 ENOG4105BZU Histidine kinase FBF59_20910 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) FBF59_20915 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FBF59_20955 ENOG41067QW Transcriptional regulator FBF59_20960 ENOG4105DF6 Fe-S oxidoreductase FBF59_20970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FBF59_20975 ENOG4105C1G acyl-Coa dehydrogenase FBF59_20980 ENOG4105C1G acyl-Coa dehydrogenase FBF59_21020 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FBF59_21025 ENOG4105CBT Fructose-1,6-bisphosphatase FBF59_21030 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FBF59_21045 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FBF59_21050 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FBF59_21055 ENOG4108ZXQ stage ii sporulation protein r FBF59_21065 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FBF59_21090 ENOG4107XC4 flavin reductase domain protein, FMN-binding FBF59_21095 ENOG4108VGI doxx family FBF59_21110 ENOG4108YZG isomerase FBF59_21115 ENOG4108UIC UPF0340 protein FBF59_21140 ENOG41062M3 atp synthase FBF59_21145 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FBF59_21195 ENOG4105BZU Histidine kinase FBF59_21200 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FBF59_21210 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FBF59_21215 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FBF59_21240 ENOG4105D65 subunit l FBF59_21245 ENOG4105C8S subunit m FBF59_21250 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FBF59_21255 ENOG4106778 Protein of unknown function (DUF1146) FBF59_21275 ENOG4105DY9 regulatoR FBF59_21290 ENOG4105FRN stage II sporulation protein FBF59_21300 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FBF59_21315 ENOG4107YJ4 chain length determinant protein FBF59_21320 ENOG4105HTX biosynthesis protein FBF59_21325 ENOG4107YJ4 chain length determinant protein FBF59_21330 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FBF59_21335 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FBF59_21340 ENOG4105D3Q Sugar transferase FBF59_21355 ENOG4105CPK Glycosyl transferase (Group 1 FBF59_21365 ENOG4105C6Y Udp-glucose 6-dehydrogenase FBF59_21370 ENOG4105CMR udp-glucose 4-epimerase FBF59_21375 ENOG4108KGH TRANSCRIPTIONal FBF59_21385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_21390 ENOG4105BZU Histidine kinase FBF59_21405 ENOG4105CXY transporter FBF59_21425 ENOG4105C19 ABC transporter FBF59_21430 ENOG4107RBB ABC transporter, permease FBF59_21440 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FBF59_21470 ENOG4105C0D helicase FBF59_21475 ENOG4105KBK Zinc finger, swim domain protein FBF59_21500 ENOG41069ER domain protein FBF59_21510 ENOG4105C94 Transporter FBF59_21515 ENOG4107R8N Glycosyl transferase, family 2 FBF59_21540 ENOG4105E0M Sulfatase FBF59_21555 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FBF59_21565 ENOG4105DAA L-lactate FBF59_21595 ENOG4107RSM transcriptional regulator FBF59_21600 ENOG4105ECB domain protein FBF59_21625 ENOG4105VZJ PTS System FBF59_21635 ENOG4105VCP PTS System FBF59_21640 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FBF59_21645 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FBF59_21655 ENOG4105CK1 PTS System FBF59_21660 ENOG4105VCP PTS System FBF59_21665 ENOG4105F8D glycoside hydrolase family 4 FBF59_21690 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FBF59_21700 ENOG4105ESV Glycosyl transferase, family 4 FBF59_21705 ENOG4105C6Y Udp-glucose 6-dehydrogenase FBF59_21710 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FBF59_21715 ENOG4108KGH TRANSCRIPTIONal FBF59_21720 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FBF59_21730 ENOG4105KVH Transcriptional regulator FBF59_21745 ENOG41081UC Inherit from COG: Competence protein FBF59_21750 ENOG4105VEQ Cold shock protein FBF59_21755 ENOG4105MS2 ribosomal subunit Interface protein FBF59_21775 ENOG4105CAK Cell division ATP-binding protein ftsE FBF59_21780 ENOG4105CRP Part of the ABC transporter FtsEX involved in FBF59_21785 ENOG4105CN1 protease FBF59_21795 ENOG4105BZ1 (ABC) transporter FBF59_21805 ENOG4105C5H ABC transporter FBF59_21810 ENOG4108WS4 fmn reductase FBF59_21820 ENOG4105DUM transcriptional regulator, lysR family FBF59_21825 ENOG4105HMI Membrane FBF59_21840 ENOG4107TXC Transcriptional regulator FBF59_21860 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FBF59_21870 ENOG41086DT Membrane protein of unknown function FBF59_21890 ENOG4108S4C acetyltransferase FBF59_21900 ENOG4105C3M thioredoxin reductase FBF59_21910 ENOG4108Z4K mutator MutT protein FBF59_21920 ENOG4105CHW UPF0052 protein FBF59_21930 ENOG4105KRI phosphocarrier protein (HPr FBF59_21935 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FBF59_21940 ENOG4108QY0 Membrane FBF59_21955 ENOG4105CZ3 stage V sporulation protein ad FBF59_21960 ENOG41090VF Stage v sporulation protein ac FBF59_21980 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FBF59_22030 ENOG41067MG lrgb family FBF59_22035 ENOG4105XZU Preprotein translocase, subunit SecG FBF59_22045 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FBF59_22075 ENOG4105CM4 permease protein FBF59_22080 ENOG4108IPW abc transporter atp-binding protein FBF59_22095 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FBF59_22100 ENOG4108V2W Carbonate dehydratase FBF59_22120 ENOG4108W2Y isochorismatase FBF59_22130 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FBF59_22140 ENOG4108MK9 spermidine N(1)-acetyltransferase FBF59_22145 ENOG4105C5H ABC transporter FBF59_22165 ENOG4105WMR Protein CrcB homolog FBF59_22180 ENOG4105C8Q Methyl-accepting chemotaxis FBF59_22190 ENOG4105D4A Cell wall formation (By similarity) FBF59_22195 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FBF59_22215 ENOG4105KVH Transcriptional regulator FBF59_22220 ENOG4105F27 Major Facilitator FBF59_22225 ENOG4105CV8 reductase FBF59_22240 ENOG4108RYK Nad-dependent epimerase dehydratase FBF59_22255 ENOG4105D9N nucleoside FBF59_22265 ENOG4105D9N nucleoside FBF59_22275 ENOG41090A1 ferritin FBF59_22285 ENOG4108URH decarboxylase FBF59_22300 ENOG4108RMU ferritin dps family protein FBF59_22310 ENOG4105NCW Trka-c domain protein FBF59_22315 ENOG4107S91 Sodium hydrogen exchanger FBF59_22320 ENOG4107T5V SNARE associated Golgi FBF59_22335 ENOG4105C2I pirin domain protein FBF59_22340 ENOG4105D4Y metalloprotease FBF59_22350 ENOG4105VG1 fes assembly suf system protein FBF59_22355 ENOG4105C8Q Methyl-accepting chemotaxis FBF59_22360 ENOG4105C8Q Methyl-accepting chemotaxis FBF59_22385 ENOG4105BZU Histidine kinase FBF59_22390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_22395 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FBF59_22405 ENOG4107ZTW SNARE associated Golgi FBF59_22450 ENOG4107AYK membrAne FBF59_22460 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FBF59_22475 ENOG4107R7I amino acid FBF59_22480 ENOG4108SUT Major Facilitator Superfamily FBF59_22495 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FBF59_22515 ENOG4105DZ1 carboxypeptidase FBF59_22530 ENOG4105CHU acetyl-coa acetyltransferase FBF59_22535 ENOG4105C1G acyl-Coa dehydrogenase FBF59_22540 ENOG4108W8B Beta-lactamase domain protein FBF59_22555 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FBF59_22575 ENOG41080E8 Transcriptional regulator, Spx MgsR family FBF59_22600 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FBF59_22605 ENOG4108UMI ABC transporter, permease FBF59_22610 ENOG4105D01 (LipO)protein FBF59_22615 ENOG4105D01 (LipO)protein FBF59_22620 ENOG4105C3K feS assembly ATPase SufC FBF59_22625 ENOG4105JRK feS assembly protein SufD FBF59_22630 ENOG4105C9B Cysteine desulfurase FBF59_22635 ENOG4108UNV SUF system FeS assembly protein, NifU family FBF59_22640 ENOG4105DIW FeS assembly protein SUFB FBF59_22645 ENOG4107R8B 5'-nucleotidase FBF59_22650 ENOG4105KZD Domain of unknown function (DUF1805) FBF59_22655 ENOG4108YTE sporulation protein YunB FBF59_22660 ENOG4105FAA peptidase M23 FBF59_22685 ENOG41090T1 Membrane FBF59_22690 ENOG4107TXC Transcriptional regulator FBF59_22695 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FBF59_22700 ENOG4105MMD transcriptional regulator FBF59_22720 ENOG4105CBT Fructose-1,6-bisphosphatase FBF59_22735 ENOG4105D4U had-superfamily hydrolase, subfamily iia FBF59_22740 ENOG4105DYS nad(p)h dehydrogenase (quinone) FBF59_22750 ENOG4105DAX Pfam:DUF2983 FBF59_22770 ENOG4108W5N phosphatidylglycerophosphatase a FBF59_22785 ENOG41083MR nifu domain-containing protein FBF59_22830 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FBF59_22835 ENOG4105C4B ABC transporter, permease FBF59_22840 ENOG4108JJA ABC, transporter FBF59_22865 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FBF59_22900 ENOG4105EWC Purine nucleoside phosphorylase FBF59_22925 ENOG4105CEP NADH dehydrogenase FBF59_22940 ENOG41069ER domain protein FBF59_22960 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FBF59_22975 ENOG4105KA0 thioesterase Superfamily protein FBF59_22980 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FBF59_22995 ENOG4107R3E Citrate transporter FBF59_23005 ENOG4105Y38 Kinase-associated protein B FBF59_23015 ENOG4105C87 Aminotransferase class I and II FBF59_23025 ENOG4108MUZ hydrolase FBF59_23030 ENOG4105C5I Dehydrogenase FBF59_23035 ENOG4108ZB6 transcriptional regulator AsnC family FBF59_23040 ENOG4105CHM Aminotransferase FBF59_23050 ENOG4105WG9 Conserved Protein FBF59_23070 ENOG4107PBV potassium channel FBF59_23075 ENOG4105KT7 mgtC SapB transporter FBF59_23210 ENOG4108Q5F Tetr family transcriptional regulator FBF59_23215 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FBF59_23240 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FBF59_23275 ENOG4105VEQ Cold shock protein FBF59_23285 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FBF59_23290 ENOG4105E4F Isochorismate synthase FBF59_23300 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FBF59_23305 ENOG4108IPT Naphthoate synthase FBF59_23315 ENOG4105DTQ mandelate racemase muconate lactonizing FBF59_23340 ENOG41069H0 dihydroorotase EC 3.5.2.3 FBF59_23360 ENOG4105FDP GntR family transcriptional regulator FBF59_23365 ENOG4105C6Z Gluconate FBF59_23410 ENOG41082BM Transcriptional regulator, arsr family FBF59_23420 ENOG4105CJ1 ABC, transporter FBF59_23430 ENOG41086D8 Transcriptional regulator FBF59_23435 ENOG4105C19 ABC transporter FBF59_23450 ENOG4107ZTW SNARE associated Golgi FBF59_23460 ENOG4105BZU Histidine kinase FBF59_23515 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FBF59_23520 ENOG4108UGV hypoxanthine phosphoribosyltransferase FBF59_23545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_23550 ENOG4105BZU Histidine kinase FBF59_23555 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FBF59_23580 ENOG41087YS Phage shock protein A FBF59_23625 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FBF59_23630 ENOG4105C4M (Ubiquinol oxidase) subunit I FBF59_23635 ENOG4108V2W Carbonate dehydratase FBF59_23655 ENOG410839T multidrug resistance protein FBF59_23660 ENOG41080TC multidrug resistance protein FBF59_23720 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FBF59_23730 ENOG4105D2X ABC transporter substrate-binding protein FBF59_23755 ENOG4107T7U Sulfatase FBF59_23760 ENOG4107S9D Alpha beta hydrolase FBF59_23765 ENOG4105CH6 catalase FBF59_23770 ENOG4105BZU Histidine kinase FBF59_23775 ENOG4105BZU Histidine kinase FBF59_23860 ENOG4105EPU Molybdenum cofactor synthesis domain protein FBF59_23870 ENOG4105BZF Glycosyl transferase (Group 1 FBF59_23875 ENOG4105YVM Phosphoesterase, PA-phosphatase related FBF59_23880 ENOG4108Z0R Transferase FBF59_23885 ENOG4105E8V Alpha Beta Hydrolase Fold protein FBF59_23915 ENOG4105N5T Radical SAM Protein FBF59_23935 ENOG4105C19 ABC transporter FBF59_23950 ENOG4105NCW Trka-c domain protein FBF59_23955 ENOG4107S91 Sodium hydrogen exchanger FBF59_23960 ENOG410605W Major Facilitator FBF59_24000 ENOG4105DWV Homoserine O-trans-acetylase FBF59_24010 ENOG41085GJ domain protein FBF59_24030 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FBF59_24035 ENOG4105D06 uba thif-type nad fad binding protein FBF59_24045 ENOG4105CVM Molybdenum cofactor synthesis domain protein FBF59_24050 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FBF59_24055 ENOG4108ZAF Molybdopterin FBF59_24070 ENOG4105CSC Glucose uptake protein FBF59_24075 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FBF59_24080 ENOG4108VJ1 Transcriptional regulator (CarD family FBF59_24115 ENOG4105CBX hi0933 family FBF59_24130 ENOG4105YW5 deoR family transcriptional regulator FBF59_24135 ENOG4107QSE Dipeptidase FBF59_24145 ENOG4108IUM Glycogen debranching enzyme FBF59_24150 ENOG4108V15 phosphotransferase enzyme family FBF59_24165 ENOG4105C8F Beta-lactamase domain protein FBF59_24195 ENOG4108VDD TRNA binding domain protein FBF59_24230 ENOG4108IPJ Membrane FBF59_24250 ENOG4105C88 aminopeptidase FBF59_24270 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FBF59_24275 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FBF59_24285 ENOG4105ETE Transcriptional regulator (LacI family FBF59_24315 ENOG4105EP9 oxidoreductase FBF59_24320 ENOG4107SNB ankyrin repeat protein YahD FBF59_24325 ENOG4105BZU Histidine kinase FBF59_24330 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FBF59_24345 ENOG4105DGU Histone deacetylase FBF59_24350 ENOG4105W87 Cbs domain FBF59_24355 ENOG4105F1V Acetoin utilization protein FBF59_24365 ENOG4108UW5 maltose o-acetyltransferase FBF59_24390 ENOG4105C28 cystathionine FBF59_24400 ENOG4105U5Y Transcriptional regulator FBF59_24410 ENOG4107RSM transcriptional regulator FBF59_24435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FBF59_24445 ENOG4105EFZ amidohydrolase FBF59_24460 ENOG4105KBJ sporulation protein ytfj FBF59_24465 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FBF59_24475 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FBF59_24495 ENOG4108JYZ YitT family FBF59_24540 ENOG4107YZX Universal stress protein FBF59_24560 ENOG41082W1 Cupin 2, conserved barrel domain protein FBF59_24565 ENOG4105Z7P Acetyltransferase (GNAT) family FBF59_24600 ENOG4105DC7 peptidase M24 FBF59_24625 ENOG4105SFS phosphoesterase RecJ domain protein FBF59_24635 ENOG4105VV2 FBF59_24640 ENOG4105C0B DNA polymerase III (alpha subunit) FBF59_24645 ENOG4105C6K Malic enzyme FBF59_24650 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FBF59_24675 ENOG4105FS0 cytoplasmic membrane protein FBF59_24680 ENOG4108REF Sporulation integral membrane protein ytvi FBF59_24695 ENOG4105BZN citrate synthase FBF59_24700 ENOG4108HMX isocitrate dehydrogenase (NADP) FBF59_24720 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FBF59_24725 ENOG4105BZU Histidine kinase FBF59_24730 ENOG4105C2M dna polymerase I FBF59_24735 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FBF59_24745 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FBF59_24750 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FBF59_24755 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FBF59_24780 ENOG4108TDW sporulation protein YtxC FBF59_24785 ENOG4105C22 threonyL-tRNA synthetase FBF59_24790 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FBF59_24810 ENOG4105CN9 Peptidase m42 family protein FBF59_24815 ENOG4108JGH Tetr family transcriptional regulator FBF59_24820 ENOG4105CW7 secretion protein, HlyD family FBF59_24825 ENOG4105C0R drug resistance transporter emrb qaca subfamily FBF59_24850 ENOG4108RWN rrna methyltransferase FBF59_24860 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FBF59_24865 ENOG4105C5S asparaginyl-tRNA synthetase FBF59_24880 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FBF59_24895 ENOG4105DCG PHP domain protein FBF59_24905 ENOG4105FE9 pseudouridine synthase FBF59_24915 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FBF59_24925 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FBF59_24940 ENOG4105E0A ABC, transporter FBF59_24945 ENOG4105KFN sortase, SrtB family FBF59_24955 ENOG4105DR4 Methyltransferase FBF59_24965 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FBF59_25000 ENOG4105S6R Iron-hydroxamate transporter permease subunit FBF59_25005 ENOG4105J76 Periplasmic binding protein FBF59_25015 ENOG4105CEY Amp-dependent synthetase and ligase FBF59_25020 ENOG4107Z3H Transcriptional regulator, TetR family FBF59_25025 ENOG41060WC Enoyl-CoA hydratase FBF59_25030 ENOG4105BZJ Electron transfer flavoprotein FBF59_25035 ENOG4105C10 Electron transfer flavoprotein FBF59_25040 ENOG4105K63 Thioredoxin FBF59_25055 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FBF59_25065 ENOG4105E33 succinate dehydrogenase FBF59_25075 ENOG4108VXD carboxy-peptidase FBF59_25080 ENOG4105E14 MotA TolQ exbB proton channel FBF59_25085 ENOG4105ER2 Ompa motb domain protein FBF59_25090 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FBF59_25095 ENOG4108IUX (ABC) transporter FBF59_25100 ENOG4105RHA ABC transporter, permease FBF59_25105 ENOG4108Z40 Transcriptional regulator FBF59_25110 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FBF59_25120 ENOG4108JCI Transcriptional regulator FBF59_25125 ENOG41067S9 phage shock protein C, PspC FBF59_25130 ENOG4105DZC cytosine deaminase FBF59_25140 ENOG4105PFC Transcriptional regulator FBF59_25150 ENOG4105KBX Transcriptional regulator, TetR family FBF59_25160 ENOG4108PCX Major Facilitator FBF59_25170 ENOG4108XJQ germination protein FBF59_25185 ENOG4105M59 Phosphodiesterase, mj0936 family FBF59_25210 ENOG4108QCI YvbH-like oligomerisation region FBF59_25235 ENOG4108IUQ atp-dependent protease FBF59_25255 ENOG4105K56 Transcriptional regulator FBF59_25280 ENOG4105D52 delta-aminolevulinic acid dehydratase FBF59_25290 ENOG41068KH stage VI sporulation protein D FBF59_25300 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FBF59_25305 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FBF59_25325 ENOG4105DFF Rod shape-determining protein mreb FBF59_25330 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FBF59_25345 ENOG4107QMS site-determining protein FBF59_25360 ENOG4105C03 ribonuclease FBF59_25370 ENOG4105X36 (ribosomal) protein FBF59_25395 ENOG4105EWM Histidine kinase FBF59_25415 ENOG4105CQC Prephenate dehydratase FBF59_25425 ENOG4108RPX mosc domain containing protein FBF59_25440 ENOG4108IYU L-aspartate oxidase FBF59_25445 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FBF59_25475 ENOG4108HUF Transporter FBF59_25490 ENOG41061AI Protein of unknown function (DUF2905) FBF59_25505 ENOG4105VIE preprotein translocase, subunit YajC FBF59_25515 ENOG4108QG2 Membrane FBF59_25520 ENOG4105CKP Polysaccharide Biosynthesis Protein FBF59_25530 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FBF59_25535 ENOG41076HS cation diffusion facilitator family transporter FBF59_25540 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FBF59_25550 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FBF59_25565 ENOG4105CUT histidyl-tRNA synthetase FBF59_25580 ENOG4105CUZ uba thif-type nad fad binding protein FBF59_25590 ENOG4108VCI transcription factor, rsfa family FBF59_25595 ENOG4105D1H recombination factor protein RarA FBF59_25605 ENOG4105C3J Cysteine desulfurase FBF59_25610 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FBF59_25620 ENOG4105C7H Helicase, RecD TraA family FBF59_25625 ENOG41060CR FBF59_25640 ENOG4105C02 permease FBF59_25650 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FBF59_25670 ENOG4105HHA aminodeoxychorismate lyase FBF59_25675 ENOG4108VQJ O-methyltransferase FBF59_25680 ENOG4105XYU peptidase (U32 family) FBF59_25685 ENOG4105CFP Peptidase U32 FBF59_25695 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FBF59_25705 ENOG4107XRG penicillin-binding protein FBF59_25735 ENOG4105C28 cystathionine FBF59_25740 ENOG4108EKI Dehydrogenase FBF59_25755 ENOG4108V5C ABC transporter FBF59_25760 ENOG4105S6R Iron-hydroxamate transporter permease subunit FBF59_25800 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FBF59_25810 ENOG4105MIR Phenylalanine 4-monooxygenase FBF59_25815 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FBF59_25850 ENOG4108MUZ hydrolase FBF59_25855 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FBF59_25860 ENOG4105G6Z alkaline phosphatase FBF59_25875 ENOG4108TVJ Nitroreductase FBF59_25895 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FBF59_25910 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FBF59_25915 ENOG4105CQW ribosome biogenesis GTPase YqeH FBF59_25925 ENOG410812S Rna-binding protein FBF59_25935 ENOG4108WF2 Metal Dependent Phosphohydrolase FBF59_25945 ENOG4105DXX methyltransferase FBF59_25955 ENOG4105KQC Competence protein FBF59_25960 ENOG4108UK2 deaminase FBF59_25965 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FBF59_25975 ENOG4105TQK DNA polymerase iii, delta' subunit FBF59_26000 ENOG4105KVH Transcriptional regulator FBF59_26005 ENOG4105CSA Coproporphyrinogen iii oxidase FBF59_26035 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FBF59_26040 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FBF59_26050 ENOG4105KTH gatB Yqey FBF59_26060 ENOG41068P3 sporulation protein YqfC FBF59_26070 ENOG4105C9A Phoh family FBF59_26075 ENOG4105CTJ Metal Dependent Phosphohydrolase FBF59_26085 ENOG4107YR5 Diacylglycerol kinase FBF59_26090 ENOG4105KG3 cytidine deaminase FBF59_26095 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FBF59_26120 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FBF59_26125 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FBF59_26140 ENOG4105EGD dinuclear metal center protein, YbgI family FBF59_26165 ENOG41069ZM Protein of unknown function (DUF2624) FBF59_26170 ENOG4108JYZ YitT family FBF59_26175 ENOG4105FDK ABC transporter FBF59_26185 ENOG4105N80 Ferric uptake regulator, Fur family FBF59_26210 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FBF59_26240 ENOG4108IMY Transcriptional regulator FBF59_26315 ENOG4108C33 Resolvase FBF59_26410 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FBF59_26450 ENOG4107RF6 penicillin-binding protein FBF59_26460 ENOG4105C8U phosphate abc transporter FBF59_26465 ENOG4105C8U phosphate abc transporter FBF59_26470 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FBF59_26475 ENOG4108UTW Plays a role in the regulation of phosphate uptake FBF59_26490 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FBF59_26500 ENOG4105DKQ ROK family FBF59_26510 ENOG4105C5X domain protein FBF59_26530 ENOG4105C28 cystathionine FBF59_26535 ENOG4105C28 cystathionine FBF59_26545 ENOG4105C3R Methionine synthase FBF59_26550 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FBF59_26585 ENOG4107R6U sodium dicarboxylate symporter FBF59_26640 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FBF59_26670 ENOG4105C0D helicase FBF59_26715 ENOG41080TC multidrug resistance protein FBF59_26740 ENOG4105WZW rhodanese family FBF59_26745 ENOG41082GG biotin lipoate A B protein ligase FBF59_26775 ENOG4107YBY Hydrolase FBF59_26785 ENOG4105CBJ Metal-dependent enzyme FBF59_26800 ENOG4105DC7 peptidase M24 FBF59_26825 ENOG4105CD2 stage iii sporulation protein aa FBF59_26830 ENOG4105KR5 Stage iii sporulation protein FBF59_26835 ENOG4108CQH stage III sporulation protein AC FBF59_26840 ENOG4105KQ4 Stage iii sporulation protein ad FBF59_26850 ENOG410644B Stage III sporulation protein af FBF59_26875 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FBF59_26880 ENOG4108ZSR alkaline shock protein FBF59_26905 ENOG4105CTB Polyprenyl synthetase FBF59_26915 ENOG4105DX0 Hemolysin A FBF59_26920 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FBF59_26925 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FBF59_26930 ENOG4105S1Z Stage IV sporulation protein B FBF59_26940 ENOG4107QQR Sporulation FBF59_26980 ENOG4108C33 Resolvase FBF59_27030 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FBF59_27040 ENOG4108JUB Transcriptional regulator FBF59_27055 ENOG4107RDP Dehydrogenase FBF59_27075 ENOG4105CPP Dehydrogenase, E1 component FBF59_27080 ENOG4105C7S Dehydrogenase FBF59_27095 ENOG4108QY0 Membrane FBF59_27105 ENOG4105G7B Protein of unknown function (DUF2992) FBF59_27115 ENOG4108HW3 (ABC) transporter FBF59_27120 ENOG4105E5Q amino acid AbC transporter FBF59_27125 ENOG4105CDA abc transporter atp-binding protein FBF59_27130 ENOG4108QEG Membrane FBF59_27135 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FBF59_27145 ENOG4105D9U N-acetyltransferase FBF59_27150 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FBF59_27165 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FBF59_27195 ENOG4105EJQ L-serine dehydratase FBF59_27200 ENOG4105II7 pyrroline-5-carboxylate reductase FBF59_27205 ENOG41069FQ Metallo-beta-lactamase superfamily FBF59_27210 ENOG4108IXY short-chain dehydrogenase reductase FBF59_27225 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FBF59_27240 ENOG4105DBV ornithine carbamoyltransferase FBF59_27265 ENOG4105CGH 5'-nucleotidase FBF59_27270 ENOG4105DFD Na H antiporter FBF59_27280 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FBF59_27295 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FBF59_27300 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FBF59_27325 ENOG4108R6K riboflavin synthase, subunit alpha FBF59_27330 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FBF59_27350 ENOG4108YM7 Gcn5-related n-acetyltransferase FBF59_27355 ENOG4105ETE Transcriptional regulator (LacI family FBF59_27365 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FBF59_27385 ENOG4105RHY Pfam:UPF0157 FBF59_27395 ENOG4105CPC Aldo Keto reductase FBF59_27415 ENOG4105MZ9 stage II sporulation protein m FBF59_27420 ENOG4105I3K Ferric uptake regulator, Fur family FBF59_27430 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FBF59_27455 ENOG4105D7N magnesium and cobalt transport protein CorA FBF59_27490 ENOG4105DVE abc transporter atp-binding protein FBF59_27495 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FBF59_27505 ENOG4105DZ1 carboxypeptidase FBF59_27510 ENOG41082AN stage II sporulation protein FBF59_27520 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FBF59_27525 ENOG4105C8J )-transporter FBF59_27545 ENOG41090VF Stage v sporulation protein ac FBF59_27550 ENOG4105CZ3 stage V sporulation protein ad FBF59_27560 ENOG4105G6R Stage v sporulation protein ae FBF59_27570 ENOG4105J7I hydrolase FBF59_27575 ENOG4105PTM secreted protein FBF59_27580 ENOG4107ZE5 PPIases accelerate the folding of proteins FBF59_27620 ENOG4105CE4 GlcNAc 6-P deacetylase FBF59_27630 ENOG4105FDP GntR family transcriptional regulator FBF59_27640 ENOG4105CID antiterminator FBF59_27655 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FBF59_27675 ENOG4105BZU Histidine kinase FBF59_27685 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FBF59_27700 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FBF59_27725 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FBF59_27745 ENOG4105DTD Dehydrogenase FBF59_27750 ENOG4105K7K Transcriptional regulator FBF59_27785 ENOG4105CHU acetyl-coa acetyltransferase FBF59_27830 ENOG4105CG3 alpha amylase, catalytic region FBF59_27840 ENOG4107FKK extracellular solute-binding protein family 1 FBF59_27850 ENOG4105EG2 ABC transporter, permease FBF59_27855 ENOG4105FKQ transcriptional regulator FBF59_27860 ENOG4105CHM Aminotransferase FBF59_27870 ENOG4108HGU Histidine kinase FBF59_27925 ENOG4105UIN FBF59_27935 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FBF59_27950 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FBF59_27955 ENOG4105EPM Diguanylate phosphodiesterase FBF59_27970 ENOG4107IN1 Protein of unknown function (DUF1797) FBF59_27975 ENOG4108XRC Protein of unknown function (DUF458) FBF59_28010 ENOG4107ZYR domain protein FBF59_28015 ENOG4105CN5 Metallo-Beta-Lactamase FBF59_28030 ENOG4108X4Q Hydrolase FBF59_28035 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FBF59_28050 ENOG4105CPP Dehydrogenase, E1 component FBF59_28100 ENOG4105CXN decarboxylase FBF59_28120 ENOG4105ECY inositol monophosphatase FBF59_28130 ENOG4105CI3 gtp-binding protein typa FBF59_28135 ENOG4105QA2 FBF59_28155 ENOG4108IAB Phoh family FBF59_28170 ENOG4105CNI cell division protein FtsW FBF59_28180 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FBF59_28230 ENOG4106UY4 Inherit from COG: Scp-like extracellular FBF59_28245 ENOG4107TB6 phosphoglycerate mutase FBF59_28265 ENOG4106H78 methyltransferase FBF59_28275 ENOG4105H20 Sporulation integral membrane protein YlbJ FBF59_28280 ENOG4105D78 K07001 NTE family protein FBF59_28285 ENOG41063PX domain protein FBF59_28295 ENOG4105KNH Nucleic acid-binding protein FBF59_28335 ENOG4105CJN penicillin-binding protein FBF59_28340 ENOG4105CJN penicillin-binding protein FBF59_28345 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FBF59_28360 ENOG4105CNI cell division protein FtsW FBF59_28365 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FBF59_28370 ENOG4105D4A Cell wall formation (By similarity) FBF59_28380 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FBF59_28385 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FBF59_28395 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FBF59_28405 ENOG4105WR5 sporulation protein, YlmC YmxH family FBF59_28410 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FBF59_28415 ENOG4105DFA alanine racemase domain protein FBF59_28425 ENOG41067XK integral membrane protein FBF59_28430 ENOG4105DBK s4 domain protein FBF59_28440 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FBF59_28455 ENOG4105C34 Pseudouridine synthase FBF59_28535 ENOG4105DC7 peptidase M24 FBF59_28540 ENOG4105F23 Fibronectin-binding protein FBF59_28550 ENOG4105DSJ YicC domain protein FBF59_28570 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FBF59_28575 ENOG4105C25 Primosomal protein n' FBF59_28590 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FBF59_28600 ENOG4108ZF3 Phosphatase FBF59_28605 ENOG4105D9P serine threonine protein kinase FBF59_28610 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FBF59_28615 ENOG4105DJV ribulose-phosphate 3-epimerase FBF59_28620 ENOG4105FJ0 thiamine FBF59_28635 ENOG4108ZAA Alkaline-shock protein FBF59_28640 ENOG4105DP4 dak2 domain fusion protein ylov FBF59_28645 ENOG4105CB5 ATP-dependent DNA helicase recG FBF59_28660 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FBF59_28665 ENOG4105CHR reductase FBF59_28770 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FBF59_28785 ENOG4105BZ1 (ABC) transporter FBF59_28800 ENOG4105CAQ asparagine synthetase FBF59_28805 ENOG4105CHR reductase FBF59_28820 ENOG41082UD thioesterase Superfamily protein FBF59_28825 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FBF59_28830 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FBF59_28840 ENOG4105CEY Amp-dependent synthetase and ligase FBF59_28845 ENOG4105CEY Amp-dependent synthetase and ligase FBF59_28950 ENOG4107WD8 ABC transporter, permease FBF59_28955 ENOG4105E98 transcriptional regulator DeoR family FBF59_28960 ENOG4107XGZ Hydrolase FBF59_28970 ENOG4107RF6 penicillin-binding protein FBF59_28980 ENOG4105EMN RNA polymerase sigma factor FBF59_29065 ENOG4108VJ1 Transcriptional regulator (CarD family FBF59_29095 ENOG4107ZBN O-methyltransferase FBF59_29100 ENOG4105F27 Major Facilitator FBF59_29105 ENOG4105M4P Tetr family transcriptional regulator FBF59_29140 ENOG4105CZV ABC transporter FBF59_29145 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FBF59_29160 ENOG4105TRI Hydrolase FBF59_29190 ENOG4105E98 transcriptional regulator DeoR family FBF59_29310 ENOG4105EKQ RNA-directed DNA polymerase FBF59_29315 ENOG41065S2 pneumococcal vaccine antigen FBF59_29450 ENOG4108EKI Dehydrogenase FBF59_29470 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FBF59_29485 ENOG4105CNW domain protein FBF59_29490 ENOG4108IFG nitrite reductase, (NAD(P)H) FBF59_29495 ENOG4105VCQ rubredoxin FBF59_29505 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FBF59_29515 ENOG4105D7V transposase FBF59_29530 ENOG4108QTI )-transporter FBF59_29535 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FBF59_29545 ENOG4107R7I amino acid FBF59_29555 ENOG4105C7B Threonine dehydratase FBF59_29560 ENOG4105CUB amino acid FBF59_29565 ENOG4105F2M alpha beta hydrolase fold-3 domain protein FBF59_29615 ENOG4105EA8 2-Nitropropane dioxygenase FBF59_29625 ENOG4105BZU Histidine kinase FBF59_29630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_29635 ENOG4105C0H protease FBF59_29640 ENOG4107WD8 ABC transporter, permease FBF59_29660 ENOG4105NA0 Transcriptional regulator FBF59_29670 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FBF59_29695 ENOG4108NNZ chitinase FBF59_29705 ENOG4105D7V transposase FBF59_29720 ENOG4105CMT Dihydroxyacetone kinase FBF59_29730 ENOG4105KRI phosphocarrier protein (HPr FBF59_29735 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FBF59_29745 ENOG4105ETZ PTS System FBF59_29750 ENOG4105F3R pts system mannose fructose sorbose family iid FBF59_29760 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FBF59_29765 ENOG41061CK Antibiotic biosynthesis monooxygenase FBF59_29780 ENOG4105NA0 Transcriptional regulator FBF59_29790 ENOG4105PNM synthesis protein FBF59_29795 ENOG4108VXD carboxy-peptidase FBF59_29805 ENOG4108IMY Transcriptional regulator FBF59_29810 ENOG4105BZC d-serine deaminase FBF59_29840 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FBF59_29855 ENOG4105D7V transposase FBF59_29860 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FBF59_29900 ENOG4105VZ8 Transcriptional regulator FBF59_29905 ENOG4107D63 FBF59_29915 ENOG4105CHH sulfate transporter FBF59_29940 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FBF59_29995 ENOG4105BZ4 penicillin-binding protein FBF59_30005 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FBF59_30020 ENOG4105DM4 PTS System FBF59_30025 ENOG4105DG6 mannose-6-phosphate isomerase FBF59_30030 ENOG4105BZU Histidine kinase FBF59_30035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FBF59_30045 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FBF59_30060 ENOG4108IQI permease FBF59_30065 ENOG4108J5H Homocysteine s-methyltransferase FBF59_30080 ENOG4108IMY Transcriptional regulator FBF59_30085 ENOG4105BZC d-serine deaminase FBF59_30095 ENOG4105DQ6 Transposase FBF59_30115 ENOG4107SET aldo keto reductase FBF59_30195 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FBF59_30205 ENOG4105CJW magnesium transporter FBF59_30210 ENOG4105CNI cell division protein FtsW FBF59_30215 ENOG4105FQP Beta-lactamase FBF59_30240 ENOG4106A3M Cytochrome p-450 FBF59_30245 ENOG410625E FBF59_30285 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FBF59_30295 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FBF59_30300 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FBF59_30305 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FBF59_30310 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FBF59_30325 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FBF59_30335 ENOG4105CHR reductase FBF59_30340 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FBF59_30350 ENOG4108KYE ABC-2 type transporter FBF59_30355 ENOG4105CJ1 ABC, transporter FBF59_30360 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein FBF59_30580 ENOG4105C2M dna polymerase I FBF59_30870 ENOG4107XK4 dna polymerase iii subunits gamma and tau FBF59_31115 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FBF59_31120 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FBF59_31190 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FBF59_31395 ENOG4108VXD carboxy-peptidase FBF59_31535 ENOG4105IEH endo-beta-N-acetylglucosaminidase FBF59_31610 ENOG4105MZU cell filamentation protein FBF59_31660 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FBF59_31665 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FBF59_31785 ENOG4105C2M dna polymerase I FBF59_31815 ENOG410906U SprT-like FBF59_31895 ENOG4105EQI Metal Dependent Phosphohydrolase FBF59_31970 ENOG4105D9P serine threonine protein kinase FBF59_32380 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FBF59_32485 ENOG4105C4R Atp-dependent dna helicase FBF59_32595 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FBF59_32620 ENOG4105K4W Could be involved in septation (By similarity) FBF59_32650 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FBF59_33095 ENOG4108IBT Inherit from COG: transposase FBF59_33130 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FBF59_33135 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FBF59_33140 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FBF59_33145 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FBF59_33170 ENOG4105D9N nucleoside FBF59_33180 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FBF59_33190 ENOG4107TS3 membrane protein, TerC FBF59_33200 ENOG4106FN3 tellurium resistance protein FBF59_33205 ENOG4106FN3 tellurium resistance protein FBF59_33220 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FBF59_33230 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FBF59_33415 ENOG4105ZMH deoxynucleoside kinase FBF59_33435 ENOG4105GR3 Histidine kinase FBF59_33440 ENOG4105BZU Histidine kinase FBF59_33455 ENOG4105C0D helicase FBF59_33460 ENOG4105K6T rare lipoprotein A FBF59_33500 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FBF59_33505 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FBF59_33510 ENOG4105C4R Atp-dependent dna helicase FBF59_33530 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FBF59_33535 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FBF59_33565 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FBF59_33575 ENOG4108UUM single-stranded DNA-binding protein FBF59_33685 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FBF59_33740 ENOG4107JM4 Tetratricopeptide repeat FBF59_33785 ENOG4105GJD protein, conserved in bacteria FBF59_33795 ENOG4105EKQ RNA-directed DNA polymerase FBF59_33805 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FBF59_33820 ENOG4105C0B DNA polymerase III (alpha subunit) FBF59_33830 ENOG4105C0B DNA polymerase III (alpha subunit) FBF59_33955 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FBF59_34020 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FBF59_34025 ENOG410880H cysteine synthase FBF59_34030 ENOG4105C87 Aminotransferase class I and II FBF59_34045 ENOG4105KRN Transcriptional regulator, abrb family FBF59_34050 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FBF59_34055 ENOG4105K70 DNA-binding protein FBF59_34080 ENOG4105E1K spore germination protein FBF59_34315 ENOG4107RBB ABC transporter, permease FBF59_34320 ENOG4105C19 ABC transporter FBF59_34345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FBF59_34375 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FBF59_34380 ENOG4105KRN Transcriptional regulator, abrb family FBF59_34455 ENOG4105CJA serine threonine protein kinase FBF59_34460 ENOG4105BZ1 (ABC) transporter FBF59_34465 ENOG4105K7K Transcriptional regulator FBF59_34520 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FBF59_34525 ENOG4105CNA YD repeat protein FBF59_34555 ENOG4105EA8 2-Nitropropane dioxygenase FBF59_34620 ENOG4105D13 transposase FBF59_34640 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C