locus-tag class description DDE73_00020 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DDE73_00025 ENOG4105BZU Histidine kinase DDE73_00030 ENOG4107SNB ankyrin repeat protein YahD DDE73_00035 ENOG4105EP9 oxidoreductase DDE73_00065 ENOG4105ETE Transcriptional regulator (LacI family DDE73_00070 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DDE73_00090 ENOG4105C88 aminopeptidase DDE73_00115 ENOG4108IPJ Membrane DDE73_00140 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DDE73_00150 ENOG4108VDD TRNA binding domain protein DDE73_00180 ENOG4105C8F Beta-lactamase domain protein DDE73_00195 ENOG4108V15 phosphotransferase enzyme family DDE73_00200 ENOG4108IUM Glycogen debranching enzyme DDE73_00210 ENOG4107QSE Dipeptidase DDE73_00215 ENOG4105YW5 deoR family transcriptional regulator DDE73_00230 ENOG4105CBX hi0933 family DDE73_00270 ENOG4108VJ1 Transcriptional regulator (CarD family DDE73_00275 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DDE73_00280 ENOG4105CSC Glucose uptake protein DDE73_00295 ENOG4108ZAF Molybdopterin DDE73_00300 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DDE73_00305 ENOG4105CVM Molybdenum cofactor synthesis domain protein DDE73_00315 ENOG4105D06 uba thif-type nad fad binding protein DDE73_00320 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DDE73_00350 ENOG41085GJ domain protein DDE73_00360 ENOG4105DWV Homoserine O-trans-acetylase DDE73_00370 ENOG4108B31 Spore germination protein DDE73_00395 ENOG4105C8T Leucyl-tRNA synthetase DDE73_00400 ENOG410605W Major Facilitator DDE73_00405 ENOG4107S91 Sodium hydrogen exchanger DDE73_00410 ENOG4105NCW Trka-c domain protein DDE73_00430 ENOG4105C19 ABC transporter DDE73_00450 ENOG4105N5T Radical SAM Protein DDE73_00485 ENOG4105E8V Alpha Beta Hydrolase Fold protein DDE73_00490 ENOG4108Z0R Transferase DDE73_00495 ENOG4105YVM Phosphoesterase, PA-phosphatase related DDE73_00500 ENOG4105BZF Glycosyl transferase (Group 1 DDE73_00510 ENOG4105EPU Molybdenum cofactor synthesis domain protein DDE73_00590 ENOG4105BZU Histidine kinase DDE73_00595 ENOG4105BZU Histidine kinase DDE73_00600 ENOG4105CH6 catalase DDE73_00610 ENOG4107S9D Alpha beta hydrolase DDE73_00615 ENOG4107T7U Sulfatase DDE73_00640 ENOG4105D2X ABC transporter substrate-binding protein DDE73_00650 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DDE73_00715 ENOG4108V2W Carbonate dehydratase DDE73_00725 ENOG4105C4M (Ubiquinol oxidase) subunit I DDE73_00730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DDE73_00765 ENOG41087YS Phage shock protein A DDE73_00800 ENOG4105BZU Histidine kinase DDE73_00805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_00830 ENOG4108UGV hypoxanthine phosphoribosyltransferase DDE73_00835 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DDE73_00880 ENOG4105C19 ABC transporter DDE73_00895 ENOG4107ZTW SNARE associated Golgi DDE73_00910 ENOG4105C19 ABC transporter DDE73_00915 ENOG41086D8 Transcriptional regulator DDE73_00930 ENOG41082BM Transcriptional regulator, arsr family DDE73_00970 ENOG4105C6Z Gluconate DDE73_00975 ENOG4105FDP GntR family transcriptional regulator DDE73_00995 ENOG41069H0 dihydroorotase EC 3.5.2.3 DDE73_01020 ENOG4105DTQ mandelate racemase muconate lactonizing DDE73_01025 ENOG4105CEY Amp-dependent synthetase and ligase DDE73_01030 ENOG4108IPT Naphthoate synthase DDE73_01035 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DDE73_01040 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DDE73_01045 ENOG4105E4F Isochorismate synthase DDE73_01050 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DDE73_01060 ENOG4105VEQ Cold shock protein DDE73_01090 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DDE73_01105 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DDE73_01210 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DDE73_01245 ENOG4105KT7 mgtC SapB transporter DDE73_01250 ENOG4107PBV potassium channel DDE73_01270 ENOG4105WG9 Conserved Protein DDE73_01280 ENOG4105CHM Aminotransferase DDE73_01285 ENOG4108ZB6 transcriptional regulator AsnC family DDE73_01290 ENOG4105C5I Dehydrogenase DDE73_01295 ENOG4108MUZ hydrolase DDE73_01305 ENOG4105C87 Aminotransferase class I and II DDE73_01315 ENOG4105Y38 Kinase-associated protein B DDE73_01325 ENOG4107R3E Citrate transporter DDE73_01340 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DDE73_01345 ENOG4105KA0 thioesterase Superfamily protein DDE73_01360 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DDE73_01385 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) DDE73_01390 ENOG4106YN8 Prenyltransferase DDE73_01400 ENOG41069ER domain protein DDE73_01415 ENOG4105CEP NADH dehydrogenase DDE73_01445 ENOG4105EWC Purine nucleoside phosphorylase DDE73_01465 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DDE73_01490 ENOG4108JJA ABC, transporter DDE73_01495 ENOG4105C4B ABC transporter, permease DDE73_01500 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DDE73_01540 ENOG41083MR nifu domain-containing protein DDE73_01555 ENOG4108W5N phosphatidylglycerophosphatase a DDE73_01570 ENOG4105DYS nad(p)h dehydrogenase (quinone) DDE73_01580 ENOG4105D4U had-superfamily hydrolase, subfamily iia DDE73_01595 ENOG4105CBT Fructose-1,6-bisphosphatase DDE73_01620 ENOG4105MMD transcriptional regulator DDE73_01625 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DDE73_01630 ENOG4107TXC Transcriptional regulator DDE73_01635 ENOG41090T1 Membrane DDE73_01670 ENOG4105FAA peptidase M23 DDE73_01675 ENOG4108YTE sporulation protein YunB DDE73_01680 ENOG4105KZD Domain of unknown function (DUF1805) DDE73_01685 ENOG4107R8B 5'-nucleotidase DDE73_01690 ENOG4105DIW FeS assembly protein SUFB DDE73_01695 ENOG4108UNV SUF system FeS assembly protein, NifU family DDE73_01700 ENOG4105C9B Cysteine desulfurase DDE73_01705 ENOG4105JRK feS assembly protein SufD DDE73_01710 ENOG4105C3K feS assembly ATPase SufC DDE73_01715 ENOG4105D01 (LipO)protein DDE73_01720 ENOG4105D01 (LipO)protein DDE73_01725 ENOG4108UMI ABC transporter, permease DDE73_01755 ENOG41080E8 Transcriptional regulator, Spx MgsR family DDE73_01775 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DDE73_01800 ENOG4108W8B Beta-lactamase domain protein DDE73_01805 ENOG4105C1G acyl-Coa dehydrogenase DDE73_01810 ENOG4105CHU acetyl-coa acetyltransferase DDE73_01825 ENOG4105DZ1 carboxypeptidase DDE73_01845 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DDE73_01860 ENOG4108SUT Major Facilitator Superfamily DDE73_01865 ENOG4107R7I amino acid DDE73_01880 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DDE73_01890 ENOG4107AYK membrAne DDE73_01930 ENOG4107ZTW SNARE associated Golgi DDE73_01940 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DDE73_01945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_01950 ENOG4105BZU Histidine kinase DDE73_01965 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DDE73_01980 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DDE73_01985 ENOG4105VG1 fes assembly suf system protein DDE73_01990 ENOG4105D4Y metalloprotease DDE73_01995 ENOG4105C2I pirin domain protein DDE73_02010 ENOG4107T5V SNARE associated Golgi DDE73_02015 ENOG4107S91 Sodium hydrogen exchanger DDE73_02020 ENOG4105NCW Trka-c domain protein DDE73_02040 ENOG4108RMU ferritin dps family protein DDE73_02060 ENOG4108URH decarboxylase DDE73_02070 ENOG41090A1 ferritin DDE73_02080 ENOG4105D9N nucleoside DDE73_02085 ENOG4105D9N nucleoside DDE73_02100 ENOG4108RYK Nad-dependent epimerase dehydratase DDE73_02115 ENOG4105CV8 reductase DDE73_02120 ENOG4105F27 Major Facilitator DDE73_02125 ENOG4105KVH Transcriptional regulator DDE73_02140 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DDE73_02145 ENOG4105D4A Cell wall formation (By similarity) DDE73_02165 ENOG4105WMR Protein CrcB homolog DDE73_02170 ENOG4105WMR Protein CrcB homolog DDE73_02190 ENOG4105C5H ABC transporter DDE73_02195 ENOG4108MK9 spermidine N(1)-acetyltransferase DDE73_02205 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DDE73_02240 ENOG4108IPW abc transporter atp-binding protein DDE73_02245 ENOG4105CM4 permease protein DDE73_02280 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DDE73_02290 ENOG4105XZU Preprotein translocase, subunit SecG DDE73_02295 ENOG41067MG lrgb family DDE73_02315 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DDE73_02345 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDE73_02365 ENOG41090VF Stage v sporulation protein ac DDE73_02370 ENOG4105CZ3 stage V sporulation protein ad DDE73_02385 ENOG4108QY0 Membrane DDE73_02390 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DDE73_02395 ENOG4105KRI phosphocarrier protein (HPr DDE73_02405 ENOG4105CHW UPF0052 protein DDE73_02410 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DDE73_02415 ENOG4108Z4K mutator MutT protein DDE73_02425 ENOG4105C3M thioredoxin reductase DDE73_02435 ENOG4108S4C acetyltransferase DDE73_02455 ENOG41086DT Membrane protein of unknown function DDE73_02465 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DDE73_02470 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DDE73_02475 ENOG4105D7V transposase DDE73_02490 ENOG4107TXC Transcriptional regulator DDE73_02515 ENOG4105HMI Membrane DDE73_02520 ENOG4105DUM transcriptional regulator, lysR family DDE73_02530 ENOG4108WS4 fmn reductase DDE73_02550 ENOG4105BZ1 (ABC) transporter DDE73_02560 ENOG4105CN1 protease DDE73_02565 ENOG4105CRP Part of the ABC transporter FtsEX involved in DDE73_02570 ENOG4105CAK Cell division ATP-binding protein ftsE DDE73_02595 ENOG4105MS2 ribosomal subunit Interface protein DDE73_02600 ENOG4105VEQ Cold shock protein DDE73_02605 ENOG41081UC Inherit from COG: Competence protein DDE73_02620 ENOG4105KVH Transcriptional regulator DDE73_02630 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DDE73_02635 ENOG4108KGH TRANSCRIPTIONal DDE73_02640 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DDE73_02645 ENOG4105C6Y Udp-glucose 6-dehydrogenase DDE73_02650 ENOG4105ESV Glycosyl transferase, family 4 DDE73_02655 ENOG4108ZJ4 polysaccharide deacetylase DDE73_02660 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DDE73_02680 ENOG4105F8D glycoside hydrolase family 4 DDE73_02685 ENOG4105VCP PTS System DDE73_02690 ENOG4105CK1 PTS System DDE73_02700 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DDE73_02705 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DDE73_02710 ENOG4105VCP PTS System DDE73_02720 ENOG4105VZJ PTS System DDE73_02740 ENOG4105ECB domain protein DDE73_02745 ENOG4107RSM transcriptional regulator DDE73_02770 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DDE73_02795 ENOG4105DAA L-lactate DDE73_02805 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DDE73_02820 ENOG4105E0M Sulfatase DDE73_02845 ENOG4107R8N Glycosyl transferase, family 2 DDE73_02850 ENOG4105C94 Transporter DDE73_02860 ENOG41069ER domain protein DDE73_02890 ENOG4105KBK Zinc finger, swim domain protein DDE73_02895 ENOG4105C0D helicase DDE73_02925 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDE73_02935 ENOG4107RBB ABC transporter, permease DDE73_02940 ENOG4105C19 ABC transporter DDE73_02950 ENOG4105CXY transporter DDE73_02965 ENOG4105BZU Histidine kinase DDE73_02970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_02975 ENOG4105CMR udp-glucose 4-epimerase DDE73_02980 ENOG4105CMR udp-glucose 4-epimerase DDE73_02990 ENOG4108KGH TRANSCRIPTIONal DDE73_03000 ENOG4105CG5 Glycosyl transferase (Group 1 DDE73_03005 ENOG4105CG5 Glycosyl transferase (Group 1 DDE73_03025 ENOG4107RA4 Glycosyl transferase (Group 1 DDE73_03035 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DDE73_03040 ENOG4105C6Y Udp-glucose 6-dehydrogenase DDE73_03045 ENOG4105D3Q Sugar transferase DDE73_03050 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DDE73_03055 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DDE73_03060 ENOG4107YJ4 chain length determinant protein DDE73_03065 ENOG4105HTX biosynthesis protein DDE73_03070 ENOG4107YJ4 chain length determinant protein DDE73_03085 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DDE73_03095 ENOG4105FRN stage II sporulation protein DDE73_03110 ENOG4105DY9 regulatoR DDE73_03130 ENOG4106778 Protein of unknown function (DUF1146) DDE73_03135 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDE73_03140 ENOG4105C8S subunit m DDE73_03145 ENOG4105D65 subunit l DDE73_03170 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDE73_03175 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DDE73_03185 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DDE73_03190 ENOG4105BZU Histidine kinase DDE73_03240 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DDE73_03245 ENOG41062M3 atp synthase DDE73_03265 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DDE73_03270 ENOG4108UIC UPF0340 protein DDE73_03275 ENOG4108YZG isomerase DDE73_03290 ENOG4108VGI doxx family DDE73_03295 ENOG4107XC4 flavin reductase domain protein, FMN-binding DDE73_03310 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DDE73_03320 ENOG4108ZXQ stage ii sporulation protein r DDE73_03325 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DDE73_03330 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DDE73_03335 ENOG4107104 thymidine kinase DDE73_03350 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DDE73_03355 ENOG4105CBT Fructose-1,6-bisphosphatase DDE73_03360 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DDE73_03380 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DDE73_03395 ENOG4105C1G acyl-Coa dehydrogenase DDE73_03400 ENOG4105C1G acyl-Coa dehydrogenase DDE73_03405 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DDE73_03415 ENOG4105DF6 Fe-S oxidoreductase DDE73_03430 ENOG4105BZU Histidine kinase DDE73_03445 ENOG4105D4Y metalloprotease DDE73_03455 ENOG4105BZU Histidine kinase DDE73_03460 ENOG4105KCT ABC transporter DDE73_03465 ENOG4108M15 ABC transporter DDE73_03470 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DDE73_03480 ENOG4105IIU Aminopeptidase DDE73_03500 ENOG4105DU6 RNA polymerase DDE73_03515 ENOG410684U Domain of unknown function (DUF1934) DDE73_03535 ENOG4105CYW agmatinase DDE73_03545 ENOG4105DXB Major Facilitator superfamily DDE73_03550 ENOG4107SWG transcriptional regulator MERR family DDE73_03555 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DDE73_03560 ENOG4105BZ4 penicillin-binding protein DDE73_03565 ENOG4108XFG YwhD family DDE73_03570 ENOG4108Z4T Peptidase M50 DDE73_03575 ENOG41069HH 4-oxalocrotonate tautomerase DDE73_03580 ENOG4105DCI Phosphohydrolase DDE73_03585 ENOG4108MES Periplasmic binding protein DDE73_03590 ENOG4105E0A ABC, transporter DDE73_03595 ENOG4105EHG Permease protein DDE73_03600 ENOG4105DQ5 transport system permease protein DDE73_03610 ENOG4108VCI transcription factor, rsfa family DDE73_03615 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DDE73_03620 ENOG4108IJ2 phosphate acetyltransferase DDE73_03625 ENOG4107UEZ chlorite dismutase DDE73_03635 ENOG4108VKI Cell wall hydrolase DDE73_03655 ENOG4107SVH Potassium channel protein DDE73_03665 ENOG410667J hydrolase DDE73_03670 ENOG4105VCH membrane DDE73_03680 ENOG4108TU7 Inherit from COG: (ABC) transporter DDE73_03685 ENOG4105CJ1 ABC, transporter DDE73_03690 ENOG41090WU lipolytic protein G-D-S-L family DDE73_03705 ENOG4105D6E homoserine dehydrogenase DDE73_03710 ENOG4105CVG Homoserine O-transsuccinylase DDE73_03730 ENOG4108Y4K DNA-binding transcriptional activator DDE73_03740 ENOG4105WH1 Two component transcriptional regulator luxr family DDE73_03745 ENOG4105BZU Histidine kinase DDE73_03750 ENOG4105DWF phosphomethylpyrimidine kinase DDE73_03755 ENOG4105BZU Histidine kinase DDE73_03760 ENOG4105VCD cytoplasmic protein DDE73_03765 ENOG4105D22 carbon starvation protein DDE73_03775 ENOG41079KZ Major Facilitator Superfamily DDE73_03790 ENOG4105CG5 Glycosyl transferase (Group 1 DDE73_03800 ENOG4105EN6 Membrane DDE73_03805 ENOG4106YBV Methyl-accepting chemotaxis DDE73_03815 ENOG4108S4H thioesterase Superfamily protein DDE73_03820 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) DDE73_03830 ENOG4105K64 Glycosyl transferase, family 2 DDE73_03845 ENOG4105C5H ABC transporter DDE73_03850 ENOG41067SE Tetr family transcriptional regulator DDE73_03860 ENOG4105E0X reductase DDE73_03865 ENOG4106F5Q Membrane DDE73_03880 ENOG4108NEV two component transcriptional regulator, LytTR family DDE73_03890 ENOG4107RGD Major Facilitator superfamily DDE73_03910 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DDE73_03920 ENOG4105IW1 AmiS UreI transporter DDE73_03930 ENOG4105CMR udp-glucose 4-epimerase DDE73_03935 ENOG4108UT2 hemolysin iii DDE73_03945 ENOG4105C1J atp-dependent rna helicase DDE73_03950 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DDE73_03955 ENOG4105DPN Oligoendopeptidase f DDE73_03965 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DDE73_03975 ENOG4105C0H protease DDE73_03980 ENOG4105Q2H domain protein DDE73_03995 ENOG4105BZU Histidine kinase DDE73_04000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_04025 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DDE73_04030 ENOG4105CDU Replicative dna helicase DDE73_04040 ENOG4105BZR domain protein DDE73_04045 ENOG4108XMW Membrane DDE73_04055 ENOG4108UUM single-stranded DNA-binding protein DDE73_04065 ENOG4105C3G gtp-binding protein DDE73_04070 ENOG4105VDK protein, conserved in bacteria DDE73_04075 ENOG4105D8X mechanosensitive ion channel DDE73_04080 ENOG4108ZDA Sporulation protein YyaC DDE73_04085 ENOG4105FA0 parb-like partition protein DDE73_04090 ENOG4107QJE Chromosome Partitioning Protein DDE73_04105 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DDE73_04110 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DDE73_04120 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DDE73_04140 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DDE73_04145 ENOG410848D S4 domain protein YaaA DDE73_04160 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DDE73_04195 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DDE73_04230 ENOG4105ZMH deoxynucleoside kinase DDE73_04240 ENOG4105GTG Isochorismatase DDE73_04250 ENOG4108Z6B deaminase DDE73_04260 ENOG4105C6E dna polymerase iii DDE73_04280 ENOG41067KS pro-sigma K processing DDE73_04315 ENOG4105CXN decarboxylase DDE73_04325 ENOG4105FA2 dna polymerase iii DDE73_04330 ENOG4105MA4 psp1 domain protein DDE73_04340 ENOG41060K3 Methyltransferase DDE73_04350 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DDE73_04355 ENOG4105KRN Transcriptional regulator, abrb family DDE73_04360 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DDE73_04365 ENOG4105F8V Hydrolase, tatD family DDE73_04370 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DDE73_04380 ENOG4105XFA sporulation peptidase YabG DDE73_04385 ENOG4105W42 Veg protein DDE73_04400 ENOG4105DFT pur operon repressor DDE73_04405 ENOG4105KME endoribonuclease L-psp DDE73_04420 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DDE73_04425 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DDE73_04435 ENOG4108JA2 transcriptioN-repair coupling factor DDE73_04440 ENOG4108M14 stage v sporulation protein t DDE73_04450 ENOG4108IY2 MazG family DDE73_04455 ENOG41082I2 s4 domain protein DDE73_04460 ENOG4105VYY sporulation protein yabp DDE73_04475 ENOG41060GV RNA binding s1 domain protein DDE73_04495 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DDE73_04500 ENOG4108UGV hypoxanthine phosphoribosyltransferase DDE73_04505 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DDE73_04520 ENOG4105C6T cysteine synthase DDE73_04525 ENOG4105CRQ synthase (Component I) DDE73_04530 ENOG4105DDQ anthranilate synthase DDE73_04535 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DDE73_04540 ENOG4105EEI dihydropteroate synthase DDE73_04545 ENOG4105KRF dihydroneopterin aldolase DDE73_04550 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DDE73_04560 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DDE73_04650 ENOG4108Z0C Uvrb UvrC protein DDE73_04665 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DDE73_04670 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DDE73_04675 ENOG4105CTP PilT protein domain protein DDE73_04680 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DDE73_04695 ENOG4105D7W serine acetyltransferase DDE73_04710 ENOG4105C2N RNA methyltransferase TrmH family group 3 DDE73_04715 ENOG4105M0M Tetracycline resistance protein DDE73_04720 ENOG4105QIV RNA polymerase DDE73_04735 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DDE73_04760 ENOG4107Y49 methyltransferase DDE73_04775 ENOG4105XPM ribosomal protein DDE73_04885 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DDE73_04910 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DDE73_04920 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DDE73_04930 ENOG41067V7 50S ribosomal protein L36 DDE73_04955 ENOG4108JJB ABC transporter DDE73_04960 ENOG4108JJB ABC transporter DDE73_04965 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DDE73_04970 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DDE73_04995 ENOG4105D1F ATP-binding protein DDE73_05010 ENOG4108NMV polysaccharide deacetylase DDE73_05090 ENOG4105C8B TIGR00159 family DDE73_05095 ENOG4107U5W ybbr family DDE73_05110 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DDE73_05135 ENOG4108PSK reductase DDE73_05140 ENOG4108UMI ABC transporter, permease DDE73_05145 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DDE73_05150 ENOG4105D01 (LipO)protein DDE73_05155 ENOG4105EE1 crotonyl-CoA reductase DDE73_05165 ENOG4105IQ5 FAD linked oxidase domain protein DDE73_05180 ENOG4105C2C drug resistance transporter, Bcr CflA DDE73_05195 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DDE73_05200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDE73_05205 ENOG4105C3U ABC transporter DDE73_05210 ENOG4108JQ7 (ABC) transporter DDE73_05240 ENOG4108J59 Extracellular solute-binding protein, family 5 DDE73_05245 ENOG4108J59 Extracellular solute-binding protein, family 5 DDE73_05265 ENOG4105E0C molybdate abc transporter DDE73_05270 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DDE73_05275 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DDE73_05285 ENOG4105EGI Transcriptional regulator DDE73_05305 ENOG4105F6E Acyl-transferase DDE73_05325 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DDE73_05340 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DDE73_05360 ENOG4105C5H ABC transporter DDE73_05375 ENOG4105DEF Extracellular solute-binding protein, family 5 DDE73_05385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDE73_05390 ENOG4105C3U ABC transporter DDE73_05395 ENOG4108JQ7 (ABC) transporter DDE73_05400 ENOG410667J hydrolase DDE73_05430 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DDE73_05435 ENOG4105ERH Fumarylacetoacetate hydrolase DDE73_05445 ENOG4105CUB amino acid DDE73_05450 ENOG4108SC4 )-transporter DDE73_05455 ENOG4105CPF Cell wall formation (By similarity) DDE73_05460 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DDE73_05485 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DDE73_05490 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DDE73_05500 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DDE73_05605 ENOG4105K8N protein family UPF0079, ATPase DDE73_05610 ENOG41072GX Peptidase M22 Glycoprotease DDE73_05615 ENOG410801F ribosomal-protein-alanine acetyltransferase DDE73_05620 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DDE73_05625 ENOG4105C5H ABC transporter DDE73_05640 ENOG4108TYN CAAX amino terminal protease family protein DDE73_05660 ENOG4105C7N Xanthine uracil vitamin C permease DDE73_05670 ENOG4105BZU Histidine kinase DDE73_05700 ENOG4107ZXU DSBA oxidoreductase DDE73_05750 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DDE73_05790 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) DDE73_05800 ENOG4108SHN Glycosyl transferase, family 2 DDE73_05820 ENOG4105SX7 Transporter DDE73_05850 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DDE73_05855 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DDE73_05860 ENOG4105C83 adenylosuccinate lyase DDE73_05870 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DDE73_05900 ENOG4108V3E phosphoribosylglycinamide formyltransferase DDE73_05905 ENOG4105DC1 bifunctional purine biosynthesis protein purh DDE73_05910 ENOG4105C12 Phosphoribosylglycinamide synthetase DDE73_05940 ENOG4105C4R Atp-dependent dna helicase DDE73_05945 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DDE73_05965 ENOG4108W2Y isochorismatase DDE73_05975 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DDE73_05980 ENOG4108UMI ABC transporter, permease DDE73_05985 ENOG4105D01 (LipO)protein DDE73_06005 ENOG410834F Transcriptional regulator DDE73_06010 ENOG4107I77 yiaA/B two helix domain DDE73_06020 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DDE73_06030 ENOG4105CBD Diacylglycerol kinase DDE73_06040 ENOG4108JPW Aminotransferase DDE73_06050 ENOG4105C26 Dehydrogenase DDE73_06055 ENOG4105KPY Small multidrug resistance protein DDE73_06080 ENOG4105D9N nucleoside DDE73_06085 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DDE73_06105 ENOG4108W15 Protein of unknown function (DUF1456) DDE73_06125 ENOG4105DTQ mandelate racemase muconate lactonizing DDE73_06135 ENOG4105DFD Na H antiporter DDE73_06155 ENOG4105D3R alkyl hydroperoxide reductase DDE73_06160 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DDE73_06165 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DDE73_06170 ENOG4107W7X Aldolase DDE73_06175 ENOG4105EHG Permease protein DDE73_06180 ENOG4105DQ5 transport system permease protein DDE73_06185 ENOG4108V5C ABC transporter DDE73_06195 ENOG4105CAY ferredoxin--nadp reductase DDE73_06215 ENOG4106UIA DDE73_06220 ENOG4106UIA DDE73_06235 ENOG4105BZU Histidine kinase DDE73_06255 ENOG410756H nucleotidyltransferase DDE73_06260 ENOG4105D2S major facilitator superfamily DDE73_06275 ENOG4105E5Q amino acid AbC transporter DDE73_06280 ENOG4105EAB amino acid AbC transporter DDE73_06285 ENOG4105CDA abc transporter atp-binding protein DDE73_06290 ENOG4105C8Q Methyl-accepting chemotaxis DDE73_06305 ENOG4105DBV ornithine carbamoyltransferase DDE73_06315 ENOG4105C5B carbamate kinase DDE73_06320 ENOG4108W63 CRP FNR family transcriptional regulator DDE73_06330 ENOG4105DNP FAD linked oxidase domain protein DDE73_06340 ENOG4105CI1 PTS System DDE73_06355 ENOG4105C9U ATP-dependent DNA helicase RecQ DDE73_06360 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase DDE73_06370 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DDE73_06390 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DDE73_06395 ENOG4105D2X ABC transporter substrate-binding protein DDE73_06440 ENOG41062JF Transcriptional regulator DDE73_06455 ENOG4105DEU major facilitator superfamily DDE73_06470 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DDE73_06485 ENOG4108N0M stress protein DDE73_06490 ENOG4106FN3 tellurium resistance protein DDE73_06495 ENOG4106FN3 tellurium resistance protein DDE73_06500 ENOG4107TS3 membrane protein, TerC DDE73_06505 ENOG4108TTB tellurium resistance protein DDE73_06520 ENOG41068PA UPF0435 protein DDE73_06525 ENOG4105KJF protein tyrosine phosphatase DDE73_06535 ENOG4107U9T Pfam:Ribonuclease_BN DDE73_06540 ENOG4105C59 p-type ATPase DDE73_06545 ENOG4108IPJ Membrane DDE73_06565 ENOG4107ZTW SNARE associated Golgi DDE73_06580 ENOG410606W general stress protein DDE73_06585 ENOG4105UPD Calcium Proton DDE73_06620 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DDE73_06625 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DDE73_06635 ENOG4108JUB Transcriptional regulator DDE73_06645 ENOG4108IQI permease DDE73_06685 ENOG4108A04 Beta-lactamase DDE73_06700 ENOG4105CKK Glycosyl transferase, family 2 DDE73_06705 ENOG4107QQG Dehydrogenase DDE73_06710 ENOG4105C3I Nad-dependent epimerase dehydratase DDE73_06715 ENOG4105C3Q Glycosyl transferase, family 2 DDE73_06730 ENOG4105F1A Pyruvate formate-lyase DDE73_06735 ENOG4108QBV Monogalactosyldiacylglycerol synthase DDE73_06750 ENOG4105CI2 imidazolone-5-propionate hydrolase DDE73_06755 ENOG4105ECP epimerase DDE73_06785 ENOG41067AE Membrane-bound metal-dependent hydrolase DDE73_06790 ENOG4105CEN a g-specific adenine glycosylase DDE73_06795 ENOG4106BXE DDE73_06815 ENOG4105BZ1 (ABC) transporter DDE73_06820 ENOG4107NBY Membrane DDE73_06825 ENOG4105CBC glutamate synthase DDE73_06835 ENOG4108IUW ABC transporter DDE73_06855 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DDE73_06860 ENOG4105G5W regulator Fur family DDE73_06970 ENOG4105CDY transcriptional regulatory protein DDE73_06980 ENOG4108JQC penicillin-binding protein 1A DDE73_06985 ENOG4108R9S DSBA oxidoreductase DDE73_06995 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DDE73_07005 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DDE73_07010 ENOG4105BZU Histidine kinase DDE73_07015 ENOG4105CYN Serine protein kinase DDE73_07035 ENOG4105C94 Transporter DDE73_07050 ENOG4105DZ6 Band 7 protein DDE73_07060 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DDE73_07065 ENOG4108V9W transcriptional regulatory protein DDE73_07070 ENOG4105D4T Citrate transporter DDE73_07095 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DDE73_07100 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DDE73_07105 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DDE73_07110 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DDE73_07115 ENOG4105BZ7 extracellular solute-binding protein family 1 DDE73_07120 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DDE73_07125 ENOG4108STX response regulator DDE73_07130 ENOG4105US7 Histidine kinase DDE73_07155 ENOG4108MRH transcriptional regulatory protein DDE73_07165 ENOG4105C6K Malic enzyme DDE73_07175 ENOG4108UZ3 Transporter DDE73_07180 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DDE73_07190 ENOG4105BZU Histidine kinase DDE73_07195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_07200 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DDE73_07205 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DDE73_07210 ENOG4108JB9 formate dehydrogenase DDE73_07230 ENOG4105CUB amino acid DDE73_07240 ENOG4105C59 p-type ATPase DDE73_07250 ENOG4105DAP Nicotinate phosphoribosyltransferase DDE73_07290 ENOG4108KGH TRANSCRIPTIONal DDE73_07295 ENOG4105D9N nucleoside DDE73_07300 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DDE73_07305 ENOG4105C37 (CBS) domain DDE73_07310 ENOG4108IJ0 Aspartate ammonia-lyase DDE73_07315 ENOG4105DAA L-lactate DDE73_07330 ENOG4105DUX Transporter DDE73_07335 ENOG4108MES Periplasmic binding protein DDE73_07340 ENOG4105DQ5 transport system permease protein DDE73_07345 ENOG4108IHU transport system permease protein DDE73_07350 ENOG4105E0A ABC, transporter DDE73_07360 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DDE73_07365 ENOG4105EXW epimerase dehydratase DDE73_07370 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DDE73_07380 ENOG4107T89 von Willebrand factor, type A DDE73_07385 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DDE73_07390 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DDE73_07400 ENOG4105BZU Histidine kinase DDE73_07410 ENOG4105D5Q Arginine ornithine antiporter DDE73_07415 ENOG4107414 GntR family transcriptional regulator DDE73_07420 ENOG4105C5Y PTS System DDE73_07425 ENOG4105CG3 alpha amylase, catalytic region DDE73_07440 ENOG4105E1K spore germination protein DDE73_07445 ENOG4105CRN Aminoglycoside phosphotransferase DDE73_07450 ENOG4105BZG amino acid carrier protein DDE73_07460 ENOG4105CDA abc transporter atp-binding protein DDE73_07465 ENOG4105CT1 (ABC) transporter DDE73_07470 ENOG4105EAD ABC transporter DDE73_07475 ENOG4105DRP amino acid AbC transporter DDE73_07480 ENOG4108IQI permease DDE73_07510 ENOG4105NAE bifunctional deaminase-reductase domain protein DDE73_07515 ENOG4105BZU Histidine kinase DDE73_07540 ENOG4105CHH sulfate transporter DDE73_07545 ENOG41068KF Universal stress protein DDE73_07555 ENOG4105CXY transporter DDE73_07560 ENOG41067TZ transcriptional regulator, MarR family DDE73_07565 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDE73_07570 ENOG4105ETE Transcriptional regulator (LacI family DDE73_07575 ENOG4108RVA ribokinase DDE73_07580 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DDE73_07585 ENOG4105C2J ABC transporter DDE73_07590 ENOG4105CNN ABC, transporter DDE73_07595 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DDE73_07600 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DDE73_07630 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) DDE73_07660 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DDE73_07665 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DDE73_07670 ENOG41069ER domain protein DDE73_07675 ENOG4105VZ8 Transcriptional regulator DDE73_07680 ENOG4107D63 DDE73_07695 ENOG4105DUX Transporter DDE73_07715 ENOG4105C85 amino acid DDE73_07720 ENOG4105C7N Xanthine uracil vitamin C permease DDE73_07735 ENOG4105MA6 gCN5-related N-acetyltransferase DDE73_07760 ENOG4105BZ9 Cytochrome C oxidase, subunit I DDE73_07765 ENOG4105E2S oxidase) subunit II DDE73_07785 ENOG4106CAD Protein of unknown function (DUF3311) DDE73_07790 ENOG4105E1V na solute symporter DDE73_07805 ENOG4108NHD germination protein DDE73_07810 ENOG4105CE1 Ferrous iron transport protein b DDE73_07815 ENOG4105CE1 Ferrous iron transport protein b DDE73_07820 ENOG4105CE1 Ferrous iron transport protein b DDE73_07825 ENOG4105CVA phosphate DDE73_07830 ENOG4105C8U phosphate abc transporter DDE73_07835 ENOG4105E2Z phosphate ABC transporter (Permease DDE73_07965 ENOG41080XQ Signal transduction protein with cbs domains DDE73_07985 ENOG4105ETU transcriptional activator (TenA DDE73_07995 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DDE73_08005 ENOG4108VEU Thiamine monophosphate synthase DDE73_08010 ENOG41080HI glycine oxidase DDE73_08025 ENOG4105D06 uba thif-type nad fad binding protein DDE73_08030 ENOG4105DWF phosphomethylpyrimidine kinase DDE73_08065 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) DDE73_08080 ENOG4108INS Transcriptional regulator DDE73_08090 ENOG4105C7N Xanthine uracil vitamin C permease DDE73_08100 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DDE73_08120 ENOG4105C5Y PTS System DDE73_08135 ENOG4105K63 Thioredoxin DDE73_08155 ENOG4108B31 Spore germination protein DDE73_08175 ENOG4107Y03 Nitroreductase DDE73_08180 ENOG4105ED1 spovr family DDE73_08210 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 DDE73_08210 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 DDE73_08225 ENOG4105J4Q Transcriptional regulator DDE73_08240 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DDE73_08245 ENOG4105XTG Pfam:DUF156 DDE73_08250 ENOG4105VFE sira family DDE73_08255 ENOG4107TPS domain protein DDE73_08260 ENOG4105VFE sira family DDE73_08265 ENOG4105VFE sira family DDE73_08270 ENOG41085GJ domain protein DDE73_08275 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DDE73_08280 ENOG41087NI Sulfite exporter TauE/SafE DDE73_08290 ENOG4108KGH TRANSCRIPTIONal DDE73_08320 ENOG4105EMD TRANSCRIPTIONal DDE73_08325 ENOG4105VCP PTS System DDE73_08330 ENOG4105VZJ PTS System DDE73_08350 ENOG41069ER domain protein DDE73_08355 ENOG4107RBB ABC transporter, permease DDE73_08360 ENOG4105C19 ABC transporter DDE73_08390 ENOG4105WEF catalase DDE73_08425 ENOG4107T5V SNARE associated Golgi DDE73_08455 ENOG4105CUB amino acid DDE73_08460 ENOG4107RWR Sodium hydrogen exchanger DDE73_08470 ENOG4106KNT transcriptional regulator DDE73_08475 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DDE73_08510 ENOG4108YXU transcriptional regulator AsnC family DDE73_08515 ENOG4105CH7 arginosuccinase DDE73_08520 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DDE73_08530 ENOG4105KPY Small multidrug resistance protein DDE73_08590 ENOG4107RKG DJ-1/PfpI family DDE73_08595 ENOG4105CH6 catalase DDE73_08610 ENOG4105D5Q Arginine ornithine antiporter DDE73_08615 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DDE73_08625 ENOG4105C26 Dehydrogenase DDE73_08640 ENOG4105BZ1 (ABC) transporter DDE73_08645 ENOG4105BZ1 (ABC) transporter DDE73_08660 ENOG4105DRP amino acid AbC transporter DDE73_08665 ENOG4105CDA abc transporter atp-binding protein DDE73_08680 ENOG410839P DDE73_08690 ENOG4108UH6 UPF0754 membrane protein DDE73_08700 ENOG4105BZU Histidine kinase DDE73_08705 ENOG4105WH1 Two component transcriptional regulator luxr family DDE73_08715 ENOG4107FQX Alpha-acetolactate decarboxylase DDE73_08725 ENOG4108VX5 3-methyladenine DNA glycosylase DDE73_08745 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DDE73_08750 ENOG4105D4P Coproporphyrinogen iii oxidase DDE73_08755 ENOG4105CEY Amp-dependent synthetase and ligase DDE73_08770 ENOG4105CHH sulfate transporter DDE73_08795 ENOG4105CGU Enoyl-CoA hydratase DDE73_08815 ENOG4105DER m42 family DDE73_08840 ENOG4105CIF Ornithine Cyclodeaminase DDE73_08855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDE73_08915 ENOG4108IBT Inherit from COG: transposase DDE73_08950 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) DDE73_09000 ENOG4105CSH Transporter DDE73_09010 ENOG4108MRH transcriptional regulatory protein DDE73_09020 ENOG4105M6F mutator MutT protein DDE73_09035 ENOG4105CFI type iii restriction protein res subunit DDE73_09070 ENOG4105CDU Replicative dna helicase DDE73_09095 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDE73_09110 ENOG4105D9U N-acetyltransferase DDE73_09135 ENOG4105F6J Alpha beta hydrolase fold DDE73_09175 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DDE73_09190 ENOG4105CMT Dihydroxyacetone kinase DDE73_09205 ENOG4105CMT Dihydroxyacetone kinase DDE73_09245 ENOG41069ER domain protein DDE73_09315 ENOG4105WN5 stage II sporulation protein DDE73_09325 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDE73_09335 ENOG4108MJI response regulator DDE73_09340 ENOG4105BZU Histidine kinase DDE73_09345 ENOG4105BZU Histidine kinase DDE73_09365 ENOG4105K8R UPF0145 protein DDE73_09385 ENOG4107QHE Choloylglycine hydrolase DDE73_09405 ENOG4107VRP DNA repair exonuclease DDE73_09410 ENOG4106D4I domain protein DDE73_09425 ENOG410829K Lysine exporter protein (Lyse ygga) DDE73_09450 ENOG4108MUZ hydrolase DDE73_09480 ENOG4105F0F Oxalate decarboxylase DDE73_09490 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DDE73_09505 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DDE73_09520 ENOG4105EMN RNA polymerase sigma factor DDE73_09530 ENOG4105CNI cell division protein FtsW DDE73_09535 ENOG4105EEM helicase DDE73_09545 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DDE73_09575 ENOG4105K59 histidine triad (HIT) protein DDE73_09605 ENOG410905X membrane-flanked domain protein DDE73_09610 ENOG4105CKV Membrane DDE73_09650 ENOG410905X membrane-flanked domain protein DDE73_09655 ENOG4105CKV Membrane DDE73_09660 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DDE73_09665 ENOG4105BZ4 penicillin-binding protein DDE73_09675 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DDE73_09680 ENOG4105C1Q protoporphyrinogen oxidase DDE73_09705 ENOG4105NA0 Transcriptional regulator DDE73_09720 ENOG4105ECB domain protein DDE73_09740 ENOG4108MK9 spermidine N(1)-acetyltransferase DDE73_09750 ENOG4106AXD DDE73_09755 ENOG4108RQ5 Beta-lactamase domain-containing protein DDE73_09760 ENOG4105DF9 Lipoate-protein, ligase DDE73_09770 ENOG4105CEY Amp-dependent synthetase and ligase DDE73_09895 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) DDE73_09905 ENOG4107RN3 metallophosphoesterase DDE73_09910 ENOG4107TVP HD domain protein DDE73_09915 ENOG4108AEY RNA polymerase sigma factor DDE73_09920 ENOG41086D8 Transcriptional regulator DDE73_09930 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DDE73_09950 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DDE73_09955 ENOG4105C8Q Methyl-accepting chemotaxis DDE73_09960 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) DDE73_09970 ENOG4107QP3 malate synthase g DDE73_09990 ENOG4105VEQ Cold shock protein DDE73_10025 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DDE73_10070 ENOG4105ERH Fumarylacetoacetate hydrolase DDE73_10080 ENOG4105C8Y Acetylornithine aminotransferase DDE73_10085 ENOG4106BKT UPF0344 protein DDE73_10095 ENOG4105CAQ asparagine synthetase DDE73_10100 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DDE73_10105 ENOG4105CH6 catalase DDE73_10110 ENOG4105BZU Histidine kinase DDE73_10130 ENOG4108VPT UPF0234 protein DDE73_10135 ENOG4105QNR S1 RNA binding domain protein DDE73_10140 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DDE73_10150 ENOG4107AYK membrAne DDE73_10160 ENOG41073B9 DDE73_10170 ENOG4108KP7 hydrolase DDE73_10180 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DDE73_10205 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DDE73_10210 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DDE73_10225 ENOG4105C31 Tryptophanyl-tRNA synthetase DDE73_10245 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DDE73_10250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDE73_10260 ENOG4108JQ7 (ABC) transporter DDE73_10270 ENOG4105UQX Mate efflux family protein DDE73_10295 ENOG4108ZCF integral membrane protein DDE73_10305 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DDE73_10315 ENOG4105DPN Oligoendopeptidase f DDE73_10325 ENOG4108Z18 K06886 hemoglobin DDE73_10330 ENOG4105MIX Adenylate cyclase DDE73_10335 ENOG4106EFP UPF0738 protein DDE73_10345 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DDE73_10350 ENOG4105EMS pseudouridine synthase DDE73_10370 ENOG4105K64 Glycosyl transferase, family 2 DDE73_10390 ENOG4107TVC Glycosyl transferase, family 2 DDE73_10410 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DDE73_10415 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DDE73_10425 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DDE73_10475 ENOG4108ZMI UPF0477 protein DDE73_10500 ENOG4105CK7 Sodium proline symporter DDE73_10505 ENOG4105CRQ synthase (Component I) DDE73_10510 ENOG4105DDQ anthranilate synthase DDE73_10515 ENOG4108I0Q anthranilate phosphoribosyltransferase DDE73_10535 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DDE73_10600 ENOG4105C7S Dehydrogenase DDE73_10610 ENOG4105VZ8 Transcriptional regulator DDE73_10670 ENOG4105DZ1 carboxypeptidase DDE73_10675 ENOG4105VFR signal peptidase DDE73_10710 ENOG4105C26 Dehydrogenase DDE73_10715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DDE73_10720 ENOG4105F38 ABC transporter, permease DDE73_10725 ENOG4105D38 putrescine abc transporter DDE73_10730 ENOG4107RUE extracellular solute-binding protein family 1 DDE73_10740 ENOG4105EYF MMPL domain protein DDE73_10750 ENOG4108YBP pseudouridine synthase DDE73_10760 ENOG4105K4I Scp-like extracellular DDE73_10765 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DDE73_10770 ENOG4105CQB FAD linked oxidase domain protein DDE73_10785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_10790 ENOG4105BZU Histidine kinase DDE73_10795 ENOG4105JXH GntR family transcriptional regulator DDE73_10815 ENOG4106A3R peptidase DDE73_10825 ENOG4108QTI )-transporter DDE73_10830 ENOG4107TS3 membrane protein, TerC DDE73_10835 ENOG4105CZN Potassium uptake protein DDE73_10840 ENOG410681C small acid-soluble spore protein DDE73_10845 ENOG4108Z7G MaoC domain protein dehydratase DDE73_10865 ENOG4105CHR reductase DDE73_10890 ENOG4105C4Y ABC transporter DDE73_10895 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DDE73_10900 ENOG4107RCV ABC transporter, permease DDE73_10920 ENOG4105E98 transcriptional regulator DeoR family DDE73_10930 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DDE73_10940 ENOG4105PXI polysaccharide deacetylase DDE73_10950 ENOG4105BZU Histidine kinase DDE73_10955 ENOG41090MY MarR family Transcriptional regulator DDE73_10965 ENOG4106DF1 DDE73_10970 ENOG4105BZU Histidine kinase DDE73_10975 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DDE73_10980 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DDE73_10985 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DDE73_11025 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DDE73_11055 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DDE73_11060 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DDE73_11065 ENOG4105CZV ABC transporter DDE73_11075 ENOG4105CJ1 ABC, transporter DDE73_11115 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DDE73_11120 ENOG4105EA8 2-Nitropropane dioxygenase DDE73_11125 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DDE73_11135 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DDE73_11155 ENOG4105NQC Flavodoxin DDE73_11185 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DDE73_11215 ENOG4105CZN Potassium uptake protein DDE73_11220 ENOG41063Y9 DDE73_11225 ENOG4105KBJ sporulation protein ytfj DDE73_11245 ENOG4105CM2 brancheD-chain amino acid aminotransferase DDE73_11250 ENOG4105C7K acetolactate synthase DDE73_11255 ENOG4108ZP8 Acetolactate synthase small subunit DDE73_11260 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DDE73_11275 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DDE73_11290 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DDE73_11295 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DDE73_11300 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DDE73_11305 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DDE73_11310 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DDE73_11315 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DDE73_11330 ENOG4107RVV histidinol phosphate phosphatase, hisj family DDE73_11345 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DDE73_11350 ENOG4105E0M Sulfatase DDE73_11360 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DDE73_11375 ENOG4107S4M Sulfate adenylate transferase DDE73_11380 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DDE73_11385 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DDE73_11395 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DDE73_11400 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DDE73_11405 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DDE73_11410 ENOG4105C8J )-transporter DDE73_11430 ENOG4105DFD Na H antiporter DDE73_11450 ENOG4105ENE Histidine kinase DDE73_11455 ENOG4105WH1 Two component transcriptional regulator luxr family DDE73_11475 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDE73_11500 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DDE73_11520 ENOG4105CJ3 phosphate transporter DDE73_11525 ENOG4107GRR phosphate transport regulator DDE73_11530 ENOG4105BZ4 penicillin-binding protein DDE73_11545 ENOG4105BZU Histidine kinase DDE73_11550 ENOG4105I3N Conserved Protein DDE73_11565 ENOG4105BZU Histidine kinase DDE73_11600 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DDE73_11605 ENOG4105DZ1 carboxypeptidase DDE73_11610 ENOG4108JIC nucleoside recognition domain protein DDE73_11620 ENOG4105FE9 pseudouridine synthase DDE73_11625 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DDE73_11630 ENOG4107TWT Cytochrome c biogenesis protein DDE73_11635 ENOG4105CRE cytochrome C DDE73_11640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_11645 ENOG4105BZU Histidine kinase DDE73_11650 ENOG4108WBT adenosyltransferase DDE73_11665 ENOG4108SAX Membrane DDE73_11680 ENOG4105C9U ATP-dependent DNA helicase RecQ DDE73_11685 ENOG4105I7S Abortive infection protein DDE73_11695 ENOG4107RGJ metallophosphoesterase DDE73_11700 ENOG4108XDN Transcriptional regulator DDE73_11705 ENOG4108S6Z Negative regulator of genetic competence DDE73_11730 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DDE73_11735 ENOG4107RB3 L-asparaginase DDE73_11750 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DDE73_11765 ENOG4105S2F DDE73_11770 ENOG41065D1 DDE73_11800 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DDE73_11815 ENOG4105XXQ heptaprenyl diphosphate synthase component I DDE73_11825 ENOG4105EAH synthase DDE73_11830 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DDE73_11835 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DDE73_11840 ENOG4105D49 3-dehydroquinate synthase DDE73_11850 ENOG41068YB TPR repeat-containing protein DDE73_11865 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DDE73_11870 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DDE73_11905 ENOG4108JYZ YitT family DDE73_11915 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DDE73_11920 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DDE73_11930 ENOG4105FJR Lmbe family DDE73_11935 ENOG4105CPK Glycosyl transferase (Group 1 DDE73_11955 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DDE73_11970 ENOG4105DVT helicase DDE73_11975 ENOG4105YAC DDE73_11995 ENOG4105CSM endonuclease III DDE73_12005 ENOG4105BZ4 penicillin-binding protein DDE73_12045 ENOG4106F55 Protein of unknown function (DUF1273) DDE73_12060 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DDE73_12070 ENOG4105DVT helicase DDE73_12075 ENOG4105CTD carboxy-peptidase DDE73_12095 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DDE73_12105 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DDE73_12110 ENOG4105C2W permease DDE73_12115 ENOG4105DHF Membrane DDE73_12120 ENOG410890F Dynamin family DDE73_12130 ENOG4108W0I acetyltransferase DDE73_12140 ENOG4105KHC sulfurtransferase DDE73_12195 ENOG4105HTX biosynthesis protein DDE73_12225 ENOG4105CPK Glycosyl transferase (Group 1 DDE73_12240 ENOG4108SZE gCN5-related N-acetyltransferase DDE73_12260 ENOG41081VK Ribonuclease DDE73_12325 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DDE73_12335 ENOG4107RWR Sodium hydrogen exchanger DDE73_12340 ENOG4105CN5 Metallo-Beta-Lactamase DDE73_12345 ENOG4108Z5V transcriptional regulator, merr family DDE73_12355 ENOG4105H67 Protein of unknown function (DUF421) DDE73_12360 ENOG41080C8 DUF218 domain DDE73_12410 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DDE73_12420 ENOG4107R0U MotA TolQ exbB proton channel DDE73_12425 ENOG4105ER2 Ompa motb domain protein DDE73_12430 ENOG4107YTP response regulator receiver protein DDE73_12435 ENOG4105CBS Chea signal transduction histidine kinase DDE73_12440 ENOG4105DD5 Flagellar motor switch protein DDE73_12455 ENOG4105BZU Histidine kinase DDE73_12475 ENOG4105E1Q flagellar hook-associated protein DDE73_12480 ENOG4105DTJ flagellar hook-associated protein DDE73_12485 ENOG4105DTS flagellar hook-associated DDE73_12500 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DDE73_12505 ENOG4108ZC9 flagellar basal-body rod protein flgc DDE73_12510 ENOG41075Z6 flagellar hook-basal body complex protein fliE DDE73_12515 ENOG4107U2N Flagellar M-ring protein DDE73_12520 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DDE73_12550 ENOG4105BZE flagellar hook protein, FlgE DDE73_12565 ENOG4107R88 Chemotaxis protein (CheV) DDE73_12580 ENOG4105I03 Flagellin DDE73_12585 ENOG4105I03 Flagellin DDE73_12590 ENOG4105E4C Lytic transglycosylase catalytic DDE73_12600 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DDE73_12605 ENOG4105DD5 Flagellar motor switch protein DDE73_12615 ENOG4105CN7 Flagellar biosynthetic protein FliP DDE73_12620 ENOG4105VS8 Flagellar biosynthetic protein fliq DDE73_12630 ENOG4105D00 flagellar biosynthetic protein flhB DDE73_12635 ENOG4105D7B Flagellar biosynthesis protein flha DDE73_12640 ENOG4105FZW flagellar biosynthesis regulator FlhF DDE73_12645 ENOG4105KTQ flagellar basal-body rod protein DDE73_12650 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DDE73_12685 ENOG4105KAC Antibiotic biosynthesis monooxygenase DDE73_12710 ENOG4105DUM transcriptional regulator, lysR family DDE73_12725 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DDE73_12730 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DDE73_12760 ENOG4105CVJ phosphoglycerate mutase DDE73_12770 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DDE73_12790 ENOG4105CAQ asparagine synthetase DDE73_12810 ENOG4105PGM cation diffusion facilitator family transporter DDE73_12820 ENOG4105DRR Transcriptional regulator, GntR family DDE73_12825 ENOG4108UZ3 Transporter DDE73_12835 ENOG4105CKI cobalamin synthesis protein DDE73_12840 ENOG4108PJD permease DDE73_12855 ENOG4105DFD Na H antiporter DDE73_12860 ENOG4105VUF Transcriptional regulator DDE73_12870 ENOG4105C9Q fumarate hydratase class II DDE73_12885 ENOG4107QJQ Mate efflux family protein DDE73_12890 ENOG4105EC3 peptidase S51, dipeptidase E DDE73_12910 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DDE73_13095 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDE73_13130 ENOG4105K63 Thioredoxin DDE73_13210 ENOG4105BZC d-serine deaminase DDE73_13255 ENOG4105CJ1 ABC, transporter DDE73_13275 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DDE73_13300 ENOG4108IJ0 Aspartate ammonia-lyase DDE73_13305 ENOG4105C6K Malic enzyme DDE73_13360 ENOG4105FVX DDE73_13365 ENOG4105E09 nadh pyrophosphatase DDE73_13380 ENOG4105CSR polyphosphate kinase 2 DDE73_13385 ENOG4105U3E Transcriptional regulator DDE73_13400 ENOG4105DXI Major Facilitator superfamily DDE73_13410 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DDE73_13415 ENOG4105EU0 Major facilitator Superfamily DDE73_13420 ENOG4105C6T cysteine synthase DDE73_13440 ENOG4105C8J )-transporter DDE73_13450 ENOG4105X5K response regulator receiver protein DDE73_13455 ENOG4105H67 Protein of unknown function (DUF421) DDE73_13475 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DDE73_13480 ENOG4105CHR reductase DDE73_13485 ENOG4105CM2 brancheD-chain amino acid aminotransferase DDE73_13490 ENOG4105C7K acetolactate synthase DDE73_13500 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DDE73_13505 ENOG4105C01 Dihydroxy-acid dehydratase DDE73_13510 ENOG4105C7B Threonine dehydratase DDE73_13530 ENOG4105C6X Major Facilitator DDE73_13535 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DDE73_13545 ENOG4105DY9 regulatoR DDE73_13550 ENOG4105CYC Transferase DDE73_13560 ENOG4105DQ6 Transposase DDE73_13575 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DDE73_13595 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDE73_13605 ENOG41068WN DDE73_13625 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DDE73_13630 ENOG4105C72 UPF0176 protein DDE73_13645 ENOG4105C0X amino acid DDE73_13680 ENOG410849A acetyltransferase, (GNAT) family DDE73_13705 ENOG4107RHR regulatoR DDE73_13715 ENOG4105D9N nucleoside DDE73_13720 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DDE73_13750 ENOG410811B TRANSCRIPTIONal DDE73_13765 ENOG4107RAQ aminopeptidase DDE73_13775 ENOG4107R16 Multicopper oxidase DDE73_13820 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DDE73_13860 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DDE73_13865 ENOG4108KP7 hydrolase DDE73_13870 ENOG4105C8V SAICAR synthetase DDE73_13880 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DDE73_13885 ENOG4105CHR reductase DDE73_13925 ENOG4108T5E Copper resistance protein DDE73_13930 ENOG4105KTB nuclear export factor GLE1 DDE73_13935 ENOG4107RT3 EamA-like transporter family DDE73_13940 ENOG4105GZI Transcriptional regulator DDE73_13945 ENOG4108Z40 Transcriptional regulator DDE73_13950 ENOG4107ZXU DSBA oxidoreductase DDE73_13955 ENOG4108TVJ Nitroreductase DDE73_13960 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DDE73_13965 ENOG4106F5Q Membrane DDE73_13970 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DDE73_13985 ENOG4105CKI cobalamin synthesis protein DDE73_13995 ENOG4105C0Z ABC transporter DDE73_14000 ENOG4108IV0 ABC, transporter DDE73_14005 ENOG4105C32 Amino acid ABC transporter (Permease) DDE73_14015 ENOG4105SKE transcriptional Regulator LysR family DDE73_14025 ENOG4105MDS 4-oxalocrotonate tautomerase DDE73_14045 ENOG4105C4M (Ubiquinol oxidase) subunit I DDE73_14050 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DDE73_14055 ENOG4108JJ9 ABC, transporter DDE73_14060 ENOG4108JJ8 (ABC) transporter DDE73_14070 ENOG4105K64 Glycosyl transferase, family 2 DDE73_14080 ENOG4108UT6 Transferase hexapeptide repeat containing protein DDE73_14135 ENOG4105BZ1 (ABC) transporter DDE73_14140 ENOG4105EFI regulatoR DDE73_14145 ENOG4105BZU Histidine kinase DDE73_14160 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DDE73_14165 ENOG4108ZJ4 polysaccharide deacetylase DDE73_14185 ENOG4105D6E homoserine dehydrogenase DDE73_14195 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DDE73_14210 ENOG4108KGH TRANSCRIPTIONal DDE73_14220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DDE73_14225 ENOG4105BZU Histidine kinase DDE73_14230 ENOG4107VMI polysaccharide deacetylase DDE73_14240 ENOG4105KT7 mgtC SapB transporter DDE73_14255 ENOG4105VRR gCN5-related N-acetyltransferase DDE73_14265 ENOG4105DUU IucA IucC family protein DDE73_14270 ENOG4105CEY Amp-dependent synthetase and ligase DDE73_14285 ENOG4108WBH protein TIM barrel DDE73_14290 ENOG4105YWU small acid-soluble spore protein DDE73_14300 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DDE73_14305 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DDE73_14355 ENOG4105KRN Transcriptional regulator, abrb family DDE73_14365 ENOG4105YVS arsR family transcriptional regulator DDE73_14370 ENOG4105CPC Aldo Keto reductase DDE73_14375 ENOG4107XZQ multidrug resistance protein DDE73_14385 ENOG4105KAF membrAne DDE73_14410 ENOG4105C8Q Methyl-accepting chemotaxis DDE73_14425 ENOG4108K88 Membrane DDE73_14430 ENOG4108WPJ Ferritin-like domain DDE73_14445 ENOG4105DEN Luciferase family DDE73_14460 ENOG4105VMI -acetyltransferase DDE73_14465 ENOG4107QM2 Aldo Keto reductase DDE73_14470 ENOG4105CKI cobalamin synthesis protein DDE73_14480 ENOG4105DSE periplasmic solute binding protein DDE73_14485 ENOG4105K4T epimerase DDE73_14495 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DDE73_14540 ENOG4107T5V SNARE associated Golgi DDE73_14555 ENOG4108PJD permease DDE73_14565 ENOG4108S4H thioesterase Superfamily protein DDE73_14575 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DDE73_14595 ENOG4105SXS Protein of unknown function (DUF456) DDE73_14600 ENOG4105C37 (CBS) domain DDE73_14620 ENOG4108Z7R Chaperone CsaA DDE73_14640 ENOG4108ZRV stage ii sporulation protein p DDE73_14650 ENOG4108VXD carboxy-peptidase DDE73_14660 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DDE73_14680 ENOG4108ZRV stage ii sporulation protein p DDE73_14690 ENOG4108X4Q Hydrolase DDE73_14705 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DDE73_14725 ENOG41087PP glycosyltransferase MGT family DDE73_14730 ENOG4108JYZ YitT family DDE73_14735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DDE73_14765 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DDE73_14795 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) DDE73_14800 ENOG4108MGT Required for secretion of EsxA and EsxB DDE73_14855 ENOG4105KBJ sporulation protein ytfj DDE73_14880 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDE73_14900 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DDE73_14905 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DDE73_14915 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DDE73_14920 ENOG4105EMN RNA polymerase sigma factor DDE73_14935 ENOG4105CNW domain protein DDE73_14945 ENOG4108V06 Glutathione peroxidase DDE73_14960 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DDE73_14970 ENOG4108IUE nitrate reductase beta subunit DDE73_14975 ENOG4105R3A Nitrate reductase DDE73_14985 ENOG4107V6Q Cyclic nucleotide-binding domain DDE73_14990 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DDE73_14995 ENOG4105D06 uba thif-type nad fad binding protein DDE73_15000 ENOG4105CVM Molybdenum cofactor synthesis domain protein DDE73_15005 ENOG4108ZAF Molybdopterin DDE73_15040 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DDE73_15045 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DDE73_15050 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DDE73_15055 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DDE73_15060 ENOG4108IFG nitrite reductase, (NAD(P)H) DDE73_15065 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DDE73_15100 ENOG4105MCT stage V sporulation protein S DDE73_15145 ENOG4105C5H ABC transporter DDE73_15160 ENOG4108UUM single-stranded DNA-binding protein DDE73_15180 ENOG4107YX5 Pfam:DUF548 DDE73_15185 ENOG4105C75 arginyL-tRNA synthetase DDE73_15210 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DDE73_15225 ENOG4105C5S asparaginyl-tRNA synthetase DDE73_15230 ENOG4105C8J )-transporter DDE73_15250 ENOG4107XGZ Hydrolase DDE73_15255 ENOG4105CY2 Citrate transporter DDE73_15275 ENOG4105KD7 acetyltransferase DDE73_15285 ENOG4105VMP Transcriptional regulator DDE73_15290 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DDE73_15315 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DDE73_15330 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) DDE73_15335 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DDE73_15345 ENOG4107RVG penicillin-binding protein DDE73_15350 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DDE73_15355 ENOG4105E9Q Acyl-transferase DDE73_15360 ENOG4108UT2 hemolysin iii DDE73_15370 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DDE73_15380 ENOG4108RCR degv family DDE73_15390 ENOG4108KF3 Electron transport protein SCO1 SenC DDE73_15395 ENOG4107Y70 Heat shock protein DDE73_15400 ENOG4105CAQ asparagine synthetase DDE73_15415 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DDE73_15420 ENOG4108MES Periplasmic binding protein DDE73_15425 ENOG4105F0I Aminotransferase DDE73_15460 ENOG4105D8X mechanosensitive ion channel DDE73_15465 ENOG4105BZU Histidine kinase DDE73_15470 ENOG4105WH1 Two component transcriptional regulator luxr family DDE73_15475 ENOG4106KNT transcriptional regulator DDE73_15480 ENOG4107ZY0 Phenazine biosynthesis-like protein DDE73_15500 ENOG4105CMG Carbohydrate kinase DDE73_15505 ENOG4105C6Z Gluconate DDE73_15515 ENOG4108YV3 Protein of unknown function (DUF2711) DDE73_15545 ENOG4108IJ8 ABC transporter DDE73_15550 ENOG4105E90 ABC transporter DDE73_15585 ENOG4105C37 (CBS) domain DDE73_15610 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DDE73_15625 ENOG4107S4Y M20 DapE family protein YgeY DDE73_15630 ENOG4108TSC N-acetyltransferase DDE73_15635 ENOG4108JUB Transcriptional regulator DDE73_15640 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DDE73_15685 ENOG410841Q phosphoesterase PA-phosphatase related protein DDE73_15695 ENOG4105SZ6 Thioredoxin DDE73_15750 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DDE73_15805 ENOG4105BZ4 penicillin-binding protein DDE73_15815 ENOG4105CZM Major Facilitator DDE73_15820 ENOG4105W8X HesB YadR YfhF-family protein DDE73_15830 ENOG4105DXD 2-methylcitrate dehydratase DDE73_15835 ENOG4105CR4 methylisocitrate lyase DDE73_15840 ENOG4105C1G acyl-Coa dehydrogenase DDE73_15845 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DDE73_15855 ENOG4105N14 lysine exporter protein LysE YggA DDE73_15860 ENOG4105E39 Enoyl-CoA hydratase DDE73_15875 ENOG4107RFY SbcCD D subunit DDE73_15880 ENOG4105EYH Exonuclease DDE73_15900 ENOG4105FCD Major Facilitator DDE73_15910 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DDE73_15915 ENOG4105E4F Isochorismate synthase DDE73_15920 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DDE73_15925 ENOG4105WQI isochorismatase DDE73_15930 ENOG4105CEY Amp-dependent synthetase and ligase DDE73_15935 ENOG4105WQT MbtH domain protein DDE73_15940 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDE73_15955 ENOG4105K70 DNA-binding protein DDE73_15975 ENOG4105BZG amino acid carrier protein DDE73_15995 ENOG4105FE9 pseudouridine synthase DDE73_16000 ENOG4105C22 threonyL-tRNA synthetase DDE73_16005 ENOG4105C19 ABC transporter DDE73_16020 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DDE73_16040 ENOG41081I9 integral membrane protein DDE73_16050 ENOG4108Y4K DNA-binding transcriptional activator DDE73_16060 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) DDE73_16070 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DDE73_16080 ENOG4105EYF MMPL domain protein DDE73_16125 ENOG4105WCN acetyltransferase DDE73_16150 ENOG4105C1Q protoporphyrinogen oxidase DDE73_16160 ENOG41068WN DDE73_16190 ENOG4107V2S Transcriptional regulator DDE73_16195 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DDE73_16215 ENOG4105DND Transcriptional regulator DDE73_16220 ENOG4108RPX mosc domain containing protein DDE73_16235 ENOG4105BZ1 (ABC) transporter DDE73_16240 ENOG4105BZ1 (ABC) transporter DDE73_16300 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DDE73_16305 ENOG4108KPJ rna polymerase sigma factor DDE73_16325 ENOG4105F32 YngK protein DDE73_16345 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DDE73_16350 ENOG4105RD7 BadF BadG BcrA BcrD DDE73_16355 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DDE73_16360 ENOG4107STF Involved in phosphonate degradation (By similarity) DDE73_16365 ENOG4105C7B Threonine dehydratase DDE73_16370 ENOG4108INS Transcriptional regulator DDE73_16385 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DDE73_16395 ENOG4105C1J atp-dependent rna helicase DDE73_16410 ENOG4108RZE Tetr family transcriptional regulator DDE73_16430 ENOG41088CC tellurite resistance protein tehB DDE73_16440 ENOG4108I0C methyltransferase DDE73_16445 ENOG4107RA9 decarboxylase DDE73_16450 ENOG4105K56 Transcriptional regulator DDE73_16455 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DDE73_16480 ENOG4105CIN aminoacyl-histidine dipeptidase DDE73_16505 ENOG4105KRN Transcriptional regulator, abrb family DDE73_16515 ENOG4105EJ9 Membrane DDE73_16520 ENOG4105EQK -acetyltransferase DDE73_16630 ENOG4105FQP Beta-lactamase DDE73_16635 ENOG4107RVG penicillin-binding protein DDE73_16650 ENOG4107RF6 penicillin-binding protein DDE73_16655 ENOG4107RF6 penicillin-binding protein DDE73_16665 ENOG4105DIN metallophosphoesterase DDE73_16675 ENOG4105CJ1 ABC, transporter DDE73_16685 ENOG4107Z3H Transcriptional regulator, TetR family DDE73_16700 ENOG4105C1G acyl-Coa dehydrogenase DDE73_16705 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DDE73_16710 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DDE73_16715 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DDE73_16720 ENOG4105E39 Enoyl-CoA hydratase DDE73_16730 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DDE73_16755 ENOG4105DBI uridine monophosphokinase DDE73_16780 ENOG4105DZ1 carboxypeptidase DDE73_16795 ENOG4105T9C HD domain DDE73_16805 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DDE73_16825 ENOG41075H3 AraC family transcriptional regulator DDE73_16855 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DDE73_16865 ENOG4107Y80 Major Facilitator superfamily DDE73_16870 ENOG4105CHR reductase DDE73_16875 ENOG4105KVH Transcriptional regulator DDE73_16895 ENOG4105MDS 4-oxalocrotonate tautomerase DDE73_16900 ENOG4107V2S Transcriptional regulator DDE73_16950 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DDE73_16960 ENOG4105DK7 lysyl-tRNA synthetase DDE73_17025 ENOG4105D6E homoserine dehydrogenase DDE73_17035 ENOG4105CPF Cell wall formation (By similarity) DDE73_17040 ENOG4105ETU transcriptional activator (TenA DDE73_17140 ENOG410667J hydrolase DDE73_17145 ENOG4105BZU Histidine kinase DDE73_17150 ENOG4107RF6 penicillin-binding protein DDE73_17175 ENOG4108JJB ABC transporter DDE73_17190 ENOG4108HGU Histidine kinase DDE73_17255 ENOG4105CB2 alcohol dehydrogenase DDE73_17260 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DDE73_17265 ENOG4105CJN penicillin-binding protein DDE73_17305 ENOG4108V4B ThiJ pfpI DDE73_17310 ENOG4107TXC Transcriptional regulator DDE73_17315 ENOG4107Y80 Major Facilitator superfamily DDE73_17330 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DDE73_17355 ENOG4107Y9U Membrane DDE73_17395 ENOG4105FCD Major Facilitator DDE73_17410 ENOG4105E09 nadh pyrophosphatase DDE73_17415 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DDE73_17435 ENOG4105KME endoribonuclease L-psp DDE73_17460 ENOG4108NRW Phospholipase, patatin family DDE73_17465 ENOG4105KWG Pfam:DUF1696 DDE73_17475 ENOG4108YYS metal-dependent hydrolase (By similarity) DDE73_17490 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DDE73_17500 ENOG4105PKS Excinuclease abc c subunit domain protein DDE73_17530 ENOG4105CJ1 ABC, transporter DDE73_17550 ENOG4107VFR oxidoreductase DDE73_17580 ENOG4105U0R haloacid dehalogenase-like hydrolase DDE73_17605 ENOG4105DY8 decarboxylase DDE73_17620 ENOG4108IUM Glycogen debranching enzyme DDE73_17630 ENOG4105CGH 5'-nucleotidase DDE73_17645 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DDE73_17650 ENOG4105FDR Membrane DDE73_17660 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DDE73_17705 ENOG4105MSI germination protein ypeb DDE73_17735 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DDE73_17740 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DDE73_17745 ENOG4107Z3H Transcriptional regulator, TetR family DDE73_17795 ENOG4105E98 transcriptional regulator DeoR family DDE73_17810 ENOG41062ES Transcriptional regulator DDE73_17830 ENOG4107QKR Dehydrogenase DDE73_17840 ENOG4107RUY (E1 component), alpha subunit DDE73_17850 ENOG4105E1F short-chain dehydrogenase reductase DDE73_17855 ENOG4105RHY Pfam:UPF0157 DDE73_17890 ENOG4107SQ8 Glycine betaine DDE73_17895 ENOG4108IJ7 Glycine betaine DDE73_17905 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DDE73_17920 ENOG4105E66 phosphoriboisomerase A DDE73_17925 ENOG41082BV acetyltransferase DDE73_17930 ENOG4108M1A Chitin-binding protein DDE73_17980 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DDE73_17985 ENOG4105MSB protein, conserved in bacteria DDE73_18010 ENOG4108Z7F N-acetyltransferase DDE73_18030 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DDE73_18035 ENOG4105EEM helicase DDE73_18050 ENOG4105C9U ATP-dependent DNA helicase RecQ DDE73_18105 ENOG4108M1A Chitin-binding protein DDE73_18125 ENOG4105BZG amino acid carrier protein DDE73_18130 ENOG4105C26 Dehydrogenase DDE73_18135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DDE73_18140 ENOG4105CTU Proline racemase DDE73_18145 ENOG4105CTU Proline racemase DDE73_18150 ENOG41080HI glycine oxidase DDE73_18160 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DDE73_18190 ENOG4107T5V SNARE associated Golgi DDE73_18200 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DDE73_18220 ENOG4105DTQ mandelate racemase muconate lactonizing DDE73_18235 ENOG4107SET aldo keto reductase DDE73_18275 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DDE73_18280 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DDE73_18285 ENOG4105BZU Histidine kinase DDE73_18290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_18315 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 DDE73_18330 ENOG4105DPN Oligoendopeptidase f DDE73_18335 ENOG4105EPR degv family DDE73_18380 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DDE73_18385 ENOG4106K7D Major facilitator family transporter DDE73_18405 ENOG4107BMA Transglycosylase associated protein DDE73_18420 ENOG41089UC methyltransferase, type 11 DDE73_18455 ENOG4105CHM Aminotransferase DDE73_18510 ENOG4105C02 permease DDE73_18520 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DDE73_18525 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DDE73_18530 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DDE73_18535 ENOG4105D7T ABC transporter DDE73_18570 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DDE73_18610 ENOG4107VC0 DNA alkylation repair enzyme DDE73_18615 ENOG4105C6T cysteine synthase DDE73_18620 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DDE73_18630 ENOG4107VMI polysaccharide deacetylase DDE73_18640 ENOG4108ZCF integral membrane protein DDE73_18645 ENOG4105E0M Sulfatase DDE73_18650 ENOG4105C5H ABC transporter DDE73_18660 ENOG4105EYF MMPL domain protein DDE73_18665 ENOG41082JN Transcriptional regulator DDE73_18685 ENOG4105CIH Imidazole acetol-phosphate transaminase DDE73_18690 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DDE73_18695 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DDE73_18755 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DDE73_18785 ENOG4105D4B ABC, transporter DDE73_18790 ENOG4105F5R ABC transporter DDE73_18795 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DDE73_18805 ENOG4105DKT Transcriptional regulator DDE73_18810 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DDE73_18820 ENOG41061GT Aldolase DDE73_18835 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DDE73_18870 ENOG4105II7 pyrroline-5-carboxylate reductase DDE73_18880 ENOG4107258 Transcriptional regulator DDE73_18900 ENOG4105ECK Fatty Acid Desaturase DDE73_18910 ENOG4107RBI VanW family DDE73_18915 ENOG4105G6Z alkaline phosphatase DDE73_18925 ENOG4105VMP Transcriptional regulator DDE73_18945 ENOG41068WN DDE73_18980 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DDE73_19035 ENOG4105C8Y Acetylornithine aminotransferase DDE73_19080 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DDE73_19160 ENOG4108TVJ Nitroreductase DDE73_19165 ENOG4105FS7 Transcriptional regulator DDE73_19185 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DDE73_19210 ENOG4108DMH HTH_ARAC DDE73_19215 ENOG4108XET gCN5-related N-acetyltransferase DDE73_19250 ENOG4107XJU UPF0178 protein DDE73_19290 ENOG410635A Membrane DDE73_19300 ENOG4108IQI permease DDE73_19315 ENOG4105F1N DNA alkylation repair DDE73_19355 ENOG4107RF6 penicillin-binding protein DDE73_19360 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DDE73_19385 ENOG4105E7W lamb ycsf family protein DDE73_19395 ENOG4105P4J Allophanate hydrolase, subunit 1 DDE73_19400 ENOG4107258 Transcriptional regulator DDE73_19410 ENOG4106N3A copper homeostasis protein cutc DDE73_19415 ENOG4108ZHR arsR family transcriptional regulator DDE73_19425 ENOG4105FDT acyl-CoA dehydrogenase DDE73_19440 ENOG4105DWD nucleoside recognition domain protein DDE73_19550 ENOG4105E2A Dehydrogenase DDE73_19565 ENOG4108IJ0 Aspartate ammonia-lyase DDE73_19570 ENOG4105HDK L-asparaginase DDE73_19575 ENOG4108IMY Transcriptional regulator DDE73_19600 ENOG4108B31 Spore germination protein DDE73_19610 ENOG4105BZU Histidine kinase DDE73_19635 ENOG41075H3 AraC family transcriptional regulator DDE73_19650 ENOG4105YWU small acid-soluble spore protein DDE73_19655 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DDE73_19660 ENOG4105CUB amino acid DDE73_19665 ENOG4105II7 pyrroline-5-carboxylate reductase DDE73_19675 ENOG4105C6K Malic enzyme DDE73_19685 ENOG4108NHD germination protein DDE73_19690 ENOG4108Q8B Spore germination protein DDE73_19715 ENOG4105CSV Glutaminase DDE73_19730 ENOG4106A3M Cytochrome p-450 DDE73_19750 ENOG4105CGH 5'-nucleotidase DDE73_19760 ENOG4105CHJ isochorismatase hydrolase DDE73_19785 ENOG41090MY MarR family Transcriptional regulator DDE73_19810 ENOG4105F6J Alpha beta hydrolase fold DDE73_19825 ENOG4108606 TspO/MBR family DDE73_19830 ENOG4105CVP deoxyribo-dipyrimidine photolyase DDE73_19855 ENOG4108TWJ NADH dehydrogenase subunit 5 DDE73_19860 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DDE73_19865 ENOG4107VMI polysaccharide deacetylase DDE73_19875 ENOG4105KY5 gCN5-related N-acetyltransferase DDE73_19880 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DDE73_19890 ENOG4105D6J arsenicaL-resistance protein DDE73_19895 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase DDE73_19900 ENOG41085FC arsR family transcriptional regulator DDE73_19915 ENOG4107P5I polyketide synthase DDE73_19920 ENOG4108IG5 Transcriptional regulator DDE73_19925 ENOG4105CHR reductase DDE73_19930 ENOG4108YXU transcriptional regulator AsnC family DDE73_20005 ENOG4105C44 Serine transporter DDE73_20025 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DDE73_20030 ENOG4105DUM transcriptional regulator, lysR family DDE73_20035 ENOG4105DWP Membrane DDE73_20065 ENOG4105CZV ABC transporter DDE73_20070 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DDE73_20080 ENOG4105N0V mono-oxygenase ydhR DDE73_20105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_20110 ENOG41062D9 Histidine kinase DDE73_20130 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DDE73_20135 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDE73_20155 ENOG4105K6H D-cysteine desulfhydrase DDE73_20170 ENOG4105JQZ Methyltransferase DDE73_20190 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DDE73_20210 ENOG4105BZU Histidine kinase DDE73_20225 ENOG4108U05 Transcriptional regulator DDE73_20230 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DDE73_20240 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DDE73_20250 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DDE73_20265 ENOG4105TRI Hydrolase DDE73_20310 ENOG4107QJQ Mate efflux family protein DDE73_20330 ENOG4105EQ0 Major Facilitator superfamily DDE73_20335 ENOG4108JGH Tetr family transcriptional regulator DDE73_20340 ENOG4107QHE Choloylglycine hydrolase DDE73_20350 ENOG4105DVH amino acid DDE73_20370 ENOG4108JQ1 Dehydrogenase DDE73_20375 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DDE73_20390 ENOG41082W1 Cupin 2, conserved barrel domain protein DDE73_20400 ENOG410874W AraC family transcriptional regulator DDE73_20420 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DDE73_20655 ENOG4108VXD carboxy-peptidase DDE73_20660 ENOG4105PNM synthesis protein DDE73_20670 ENOG4108ISG Major Facilitator DDE73_20685 ENOG4107MII Sugar-specific transcriptional regulator TrmB DDE73_20690 ENOG4105CZM Major Facilitator DDE73_20700 ENOG4105CRW Short chain fatty acid transporter DDE73_20710 ENOG4105DYS nad(p)h dehydrogenase (quinone) DDE73_20770 ENOG4108K8S endonuclease I DDE73_20775 ENOG4108Z66 YbaK ebsC protein DDE73_20780 ENOG4105CUT histidyl-tRNA synthetase DDE73_20795 ENOG4105KVH Transcriptional regulator DDE73_20800 ENOG4108RCM Nitroreductase DDE73_20830 ENOG4108PSK reductase DDE73_20900 ENOG4105C31 Tryptophanyl-tRNA synthetase DDE73_20905 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DDE73_20945 ENOG4105EV4 Multidrug resistance protein mdtH DDE73_20975 ENOG4105C37 (CBS) domain DDE73_20990 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DDE73_20995 ENOG4105FAW cDP-glucose 4,6-dehydratase DDE73_21025 ENOG4105DDN Pentapeptide repeat-containing protein DDE73_21030 ENOG4105XDF Protein of unknown function (DUF1272) DDE73_21035 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DDE73_21040 ENOG4105CMG Carbohydrate kinase DDE73_21045 ENOG4105C6Z Gluconate DDE73_21060 ENOG4105CV1 Transketolase (EC 2.2.1.1) DDE73_21065 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DDE73_21080 ENOG4105CIS alcohol dehydrogenase DDE73_21085 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DDE73_21095 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DDE73_21110 ENOG4105C8Q Methyl-accepting chemotaxis DDE73_21115 ENOG4108UX3 '-nucleotidase DDE73_21120 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DDE73_21125 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DDE73_21130 ENOG4105KVH Transcriptional regulator DDE73_21155 ENOG4105CV8 reductase DDE73_21160 ENOG4105F27 Major Facilitator DDE73_21170 ENOG41090KN UPF0303 protein DDE73_21180 ENOG4105FS7 Transcriptional regulator DDE73_21190 ENOG4105C44 Serine transporter DDE73_21225 ENOG4105KVH Transcriptional regulator DDE73_21230 ENOG4108TZY GntR Family Transcriptional Regulator DDE73_21235 ENOG4105D9R oxidoreductase DDE73_21245 ENOG4105KVH Transcriptional regulator DDE73_21250 ENOG4105KVH Transcriptional regulator DDE73_21290 ENOG4105JAB phenazine biosynthesis protein, phzf family DDE73_21300 ENOG4105KNA -acetyltransferase DDE73_21310 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DDE73_21315 ENOG4105KVH Transcriptional regulator DDE73_21325 ENOG4107SCK Monooxygenase DDE73_21415 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DDE73_21450 ENOG4105H3G oxidoreductase DDE73_21520 ENOG4108TN2 lmbE family DDE73_21530 ENOG4107R3E Citrate transporter DDE73_21540 ENOG4105WCN acetyltransferase DDE73_21545 ENOG4108MES Periplasmic binding protein DDE73_21550 ENOG4105EHG Permease protein DDE73_21555 ENOG4105DQ5 transport system permease protein DDE73_21560 ENOG4105NX3 Membrane DDE73_21580 ENOG41068WN DDE73_21585 ENOG4107CUJ Protein of unknown function (DUF2690) DDE73_21595 ENOG4107V2S Transcriptional regulator DDE73_21615 ENOG4105C98 muts2 protein DDE73_21625 ENOG4105E5K Alpha-amylase DDE73_21630 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DDE73_21635 ENOG4105DPN Oligoendopeptidase f DDE73_21640 ENOG4108A04 Beta-lactamase DDE73_21665 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DDE73_21675 ENOG41082BM Transcriptional regulator, arsr family DDE73_21680 ENOG4105CIS alcohol dehydrogenase DDE73_21690 ENOG4107JM4 Tetratricopeptide repeat DDE73_21720 ENOG4105CQB FAD linked oxidase domain protein DDE73_21755 ENOG4105BZU Histidine kinase DDE73_21765 ENOG4105KT7 mgtC SapB transporter DDE73_21775 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DDE73_21780 ENOG41073R8 VanW family DDE73_21790 ENOG4108R1P DDE73_21805 ENOG4105VEQ Cold shock protein DDE73_21825 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DDE73_21845 ENOG410904N short-chain dehydrogenase reductase DDE73_21855 ENOG4106IQC argininosuccinate lyase DDE73_21870 ENOG4108IA2 Sodium pantothenate symporter DDE73_21880 ENOG4105C26 Dehydrogenase DDE73_21885 ENOG4105CHR reductase DDE73_21895 ENOG4105EWU Squalene--hopene cyclase DDE73_21905 ENOG4105FR1 rard protein DDE73_21910 ENOG410696E Membrane DDE73_21925 ENOG4105D1F ATP-binding protein DDE73_21935 ENOG4108ZAF Molybdopterin DDE73_21940 ENOG4105CVM Molybdenum cofactor synthesis domain protein DDE73_21945 ENOG4105D06 uba thif-type nad fad binding protein DDE73_21950 ENOG4105TMB Formate nitrite transporter DDE73_21960 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DDE73_21965 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DDE73_21975 ENOG4108JB9 formate dehydrogenase DDE73_21980 ENOG4105E1K spore germination protein DDE73_21995 ENOG4105CUB amino acid DDE73_22050 ENOG4108KGH TRANSCRIPTIONal DDE73_22060 ENOG4105EMN RNA polymerase sigma factor DDE73_22070 ENOG4105CIG ABC transporter DDE73_22080 ENOG4105D9R oxidoreductase DDE73_22090 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DDE73_22095 ENOG4105K4P CoA-binding domain protein DDE73_22100 ENOG4105C0H protease DDE73_22105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDE73_22115 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DDE73_22120 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DDE73_22125 ENOG4105W8X HesB YadR YfhF-family protein DDE73_22155 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DDE73_22160 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DDE73_22170 ENOG4108JJA ABC, transporter DDE73_22175 ENOG4108I0Z Aconitate hydratase DDE73_22205 ENOG4105E5W Transporter DDE73_22215 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DDE73_22235 ENOG4107F3J Amp-dependent synthetase and ligase DDE73_22240 ENOG4107ZYJ bioY protein DDE73_22245 ENOG4105CEY Amp-dependent synthetase and ligase DDE73_22295 ENOG4107AYK membrAne DDE73_22310 ENOG4105BZU Histidine kinase DDE73_22315 ENOG4105FBA Phospholipase Carboxylesterase DDE73_22320 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DDE73_22325 ENOG4105CK7 Sodium proline symporter DDE73_22330 ENOG4105CBC glutamate synthase DDE73_22335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DDE73_22340 ENOG4108VJ1 Transcriptional regulator (CarD family DDE73_22345 ENOG4108903 Formimidoylglutamase DDE73_22355 ENOG4105CGP Urocanate hydratase DDE73_22405 ENOG4107QIV Cytochrome c biogenesis protein DDE73_22420 ENOG4105CH2 amidohydrolase DDE73_22430 ENOG4105CJ1 ABC, transporter DDE73_22445 ENOG4107RSM transcriptional regulator DDE73_22450 ENOG4105VAW lrga family DDE73_22455 ENOG41067MG lrgb family DDE73_22495 ENOG4105BZ1 (ABC) transporter DDE73_22500 ENOG4105BZ1 (ABC) transporter DDE73_22535 ENOG4108HW3 (ABC) transporter DDE73_22540 ENOG4105CGH 5'-nucleotidase DDE73_22550 ENOG4108SVB resolvase DDE73_22570 ENOG4105K7K Transcriptional regulator DDE73_22575 ENOG4105C5F glutamine synthetase DDE73_22580 ENOG4105KV4 Transcriptional regulator DDE73_22585 ENOG4105CXI aluminum resistance protein DDE73_22590 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DDE73_22595 ENOG4105EN6 Membrane DDE73_22600 ENOG4106F1P AAA ATPase, central domain protein DDE73_22640 ENOG41069ER domain protein DDE73_22645 ENOG4105DM4 PTS System DDE73_22650 ENOG4105DE4 1-phosphofructokinase DDE73_22655 ENOG4105E98 transcriptional regulator DeoR family DDE73_22660 ENOG4107QW4 alcohol dehydrogenase DDE73_22665 ENOG4108SJC Membrane DDE73_22675 ENOG4105C85 amino acid DDE73_22700 ENOG4105K70 DNA-binding protein DDE73_22710 ENOG4105C59 p-type ATPase DDE73_22715 ENOG410681U heavy metal transport detoxification protein DDE73_22720 ENOG4105VPX protein, conserved in bacteria DDE73_22730 ENOG4105NIV Esterase DDE73_22735 ENOG4105E0A ABC, transporter DDE73_22755 ENOG4105CGK Exodeoxyribonuclease III DDE73_22765 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DDE73_22770 ENOG4105D03 DNA-3-methyladenine glycosylase II DDE73_22775 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DDE73_22795 ENOG4105BZU Histidine kinase DDE73_22835 ENOG41067MG lrgb family DDE73_22860 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C DDE73_22870 ENOG4105F0V Cell wall hydrolase DDE73_22885 ENOG4105E0M Sulfatase DDE73_22890 ENOG410890F Dynamin family DDE73_22925 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DDE73_22930 ENOG4105DQU oxidoreductase, subunit beta DDE73_22935 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DDE73_22940 ENOG4108IGT Dipeptidase DDE73_22945 ENOG4105MCT stage V sporulation protein S DDE73_22950 ENOG4105D48 metallophosphoesterase DDE73_22965 ENOG4105CEV competence damage-inducible protein DDE73_22970 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DDE73_22985 ENOG4105XZV Protein of unknown function (DUF3243) DDE73_22990 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DDE73_23010 ENOG4105UIB (ABC) transporter DDE73_23015 ENOG4108JQ9 ABC transporter DDE73_23020 ENOG4105DIH basic membrane DDE73_23025 ENOG4105FDP GntR family transcriptional regulator DDE73_23035 ENOG4105CNU cell division protein FtsK DDE73_23045 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DDE73_23060 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DDE73_23070 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DDE73_23075 ENOG4108S0H Dipicolinic acid synthetase, b subunit DDE73_23080 ENOG4105E35 Dipicolinate synthase subunit A DDE73_23090 ENOG4105C1V Peptidase, M16 DDE73_23110 ENOG4105DTN riboflavin biosynthesis protein ribF DDE73_23125 ENOG4105W7A Protein of unknown function (DUF503) DDE73_23135 ENOG4105VHM ribosomal protein DDE73_23140 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DDE73_23145 ENOG4105CHV Transcription elongation factor NusA DDE73_23155 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DDE73_23160 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DDE73_23165 ENOG4105DZP Membrane-associated zinc metalloprotease DDE73_23170 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DDE73_23175 ENOG4105KNE Phosphatidate cytidylyltransferase DDE73_23180 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DDE73_23190 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DDE73_23220 ENOG4108HE4 integrase family DDE73_23230 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DDE73_23235 ENOG4105C79 DNA protecting protein DprA DDE73_23240 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DDE73_23255 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DDE73_23280 ENOG4105VB6 UPF0109 protein DDE73_23300 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DDE73_23305 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DDE73_23320 ENOG4105CHR reductase DDE73_23325 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DDE73_23340 ENOG4105CB5 ATP-dependent DNA helicase recG DDE73_23345 ENOG4105DP4 dak2 domain fusion protein ylov DDE73_23350 ENOG4108ZAA Alkaline-shock protein DDE73_23365 ENOG4105FJ0 thiamine DDE73_23370 ENOG4105DJV ribulose-phosphate 3-epimerase DDE73_23375 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DDE73_23380 ENOG4105D9P serine threonine protein kinase DDE73_23385 ENOG4108ZF3 Phosphatase DDE73_23390 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DDE73_23395 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DDE73_23410 ENOG4105C25 Primosomal protein n' DDE73_23415 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DDE73_23435 ENOG4105DSJ YicC domain protein DDE73_23445 ENOG4105F23 Fibronectin-binding protein DDE73_23455 ENOG4105DC7 peptidase M24 DDE73_23490 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DDE73_23505 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DDE73_23510 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DDE73_23520 ENOG4105CD3 dihydroorotase DDE73_23540 ENOG4105C34 Pseudouridine synthase DDE73_23555 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DDE73_23565 ENOG4105DBK s4 domain protein DDE73_23570 ENOG41067XK integral membrane protein DDE73_23580 ENOG4105DFA alanine racemase domain protein DDE73_23585 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DDE73_23590 ENOG4105WR5 sporulation protein, YlmC YmxH family DDE73_23600 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDE73_23610 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DDE73_23615 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DDE73_23625 ENOG4105D4A Cell wall formation (By similarity) DDE73_23630 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DDE73_23635 ENOG4105CNI cell division protein FtsW DDE73_23640 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DDE73_23650 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DDE73_23655 ENOG4105CJN penicillin-binding protein DDE73_23660 ENOG4105CJN penicillin-binding protein DDE73_23675 ENOG41074B2 UPF0747 protein DDE73_23700 ENOG4105KNH Nucleic acid-binding protein DDE73_23710 ENOG41063PX domain protein DDE73_23715 ENOG4105D78 K07001 NTE family protein DDE73_23720 ENOG4105H20 Sporulation integral membrane protein YlbJ DDE73_23730 ENOG4106H78 methyltransferase DDE73_23750 ENOG4107TB6 phosphoglycerate mutase DDE73_23765 ENOG4106UY4 Inherit from COG: Scp-like extracellular DDE73_23815 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DDE73_23825 ENOG4105CNI cell division protein FtsW DDE73_23840 ENOG4108IAB Phoh family DDE73_23860 ENOG4105QA2 DDE73_23865 ENOG4105CI3 gtp-binding protein typa DDE73_23875 ENOG4105ECY inositol monophosphatase DDE73_23895 ENOG4105CXN decarboxylase DDE73_23945 ENOG4105CPP Dehydrogenase, E1 component DDE73_23960 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DDE73_23965 ENOG4108X4Q Hydrolase DDE73_23980 ENOG4105CN5 Metallo-Beta-Lactamase DDE73_23985 ENOG4107ZYR domain protein DDE73_24020 ENOG4108XRC Protein of unknown function (DUF458) DDE73_24025 ENOG4107IN1 Protein of unknown function (DUF1797) DDE73_24040 ENOG4105EPM Diguanylate phosphodiesterase DDE73_24045 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DDE73_24060 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DDE73_24070 ENOG4105UIN DDE73_24105 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DDE73_24125 ENOG4108HGU Histidine kinase DDE73_24135 ENOG4105CHM Aminotransferase DDE73_24140 ENOG4105FKQ transcriptional regulator DDE73_24145 ENOG4105EG2 ABC transporter, permease DDE73_24155 ENOG4107FKK extracellular solute-binding protein family 1 DDE73_24165 ENOG4105CG3 alpha amylase, catalytic region DDE73_24210 ENOG4105CHU acetyl-coa acetyltransferase DDE73_24245 ENOG4105K7K Transcriptional regulator DDE73_24250 ENOG4105DTD Dehydrogenase DDE73_24270 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DDE73_24280 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate DDE73_24295 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DDE73_24310 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DDE73_24320 ENOG4105BZU Histidine kinase DDE73_24340 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DDE73_24355 ENOG4105CID antiterminator DDE73_24365 ENOG4105FDP GntR family transcriptional regulator DDE73_24375 ENOG4105CE4 GlcNAc 6-P deacetylase DDE73_24415 ENOG4107ZE5 PPIases accelerate the folding of proteins DDE73_24420 ENOG4105PTM secreted protein DDE73_24425 ENOG4105J7I hydrolase DDE73_24435 ENOG4105G6R Stage v sporulation protein ae DDE73_24445 ENOG4105CZ3 stage V sporulation protein ad DDE73_24450 ENOG41090VF Stage v sporulation protein ac DDE73_24470 ENOG4105C8J )-transporter DDE73_24475 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDE73_24485 ENOG41082AN stage II sporulation protein DDE73_24490 ENOG4105DZ1 carboxypeptidase DDE73_24500 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DDE73_24505 ENOG4105DVE abc transporter atp-binding protein DDE73_24540 ENOG4105D7N magnesium and cobalt transport protein CorA DDE73_24565 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DDE73_24575 ENOG4105I3K Ferric uptake regulator, Fur family DDE73_24580 ENOG4105MZ9 stage II sporulation protein m DDE73_24600 ENOG4105CPC Aldo Keto reductase DDE73_24610 ENOG4105RHY Pfam:UPF0157 DDE73_24630 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DDE73_24640 ENOG4105ETE Transcriptional regulator (LacI family DDE73_24645 ENOG4108YM7 Gcn5-related n-acetyltransferase DDE73_24665 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DDE73_24670 ENOG4108R6K riboflavin synthase, subunit alpha DDE73_24695 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DDE73_24700 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DDE73_24710 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DDE73_24715 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DDE73_24725 ENOG4105DFD Na H antiporter DDE73_24730 ENOG4105CGH 5'-nucleotidase DDE73_24755 ENOG4105DBV ornithine carbamoyltransferase DDE73_24770 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DDE73_24785 ENOG4108IXY short-chain dehydrogenase reductase DDE73_24790 ENOG41069FQ Metallo-beta-lactamase superfamily DDE73_24795 ENOG4105II7 pyrroline-5-carboxylate reductase DDE73_24800 ENOG4105EJQ L-serine dehydratase DDE73_24815 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DDE73_24830 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DDE73_24845 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DDE73_24850 ENOG4105D9U N-acetyltransferase DDE73_24870 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DDE73_24875 ENOG4108QEG Membrane DDE73_24880 ENOG4105CDA abc transporter atp-binding protein DDE73_24885 ENOG4105E5Q amino acid AbC transporter DDE73_24890 ENOG4108HW3 (ABC) transporter DDE73_24900 ENOG4105G7B Protein of unknown function (DUF2992) DDE73_24920 ENOG4105C7S Dehydrogenase DDE73_24925 ENOG4105CPP Dehydrogenase, E1 component DDE73_24940 ENOG4105CKM Branched-chain carboxylic acid kinase DDE73_24945 ENOG4107RDP Dehydrogenase DDE73_24960 ENOG4108JUB Transcriptional regulator DDE73_24970 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DDE73_24985 ENOG4107QQR Sporulation DDE73_24995 ENOG4105S1Z Stage IV sporulation protein B DDE73_25000 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DDE73_25005 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DDE73_25010 ENOG4105DX0 Hemolysin A DDE73_25020 ENOG4105CTB Polyprenyl synthetase DDE73_25035 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DDE73_25045 ENOG4108ZSR alkaline shock protein DDE73_25050 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DDE73_25075 ENOG410644B Stage III sporulation protein af DDE73_25085 ENOG4105KQ4 Stage iii sporulation protein ad DDE73_25090 ENOG4108CQH stage III sporulation protein AC DDE73_25095 ENOG4105KR5 Stage iii sporulation protein DDE73_25100 ENOG4105CD2 stage iii sporulation protein aa DDE73_25125 ENOG4105DC7 peptidase M24 DDE73_25130 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DDE73_25140 ENOG4105CBJ Metal-dependent enzyme DDE73_25150 ENOG4107YBY Hydrolase DDE73_25180 ENOG41082GG biotin lipoate A B protein ligase DDE73_25185 ENOG4105WZW rhodanese family DDE73_25210 ENOG41080TC multidrug resistance protein DDE73_25245 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DDE73_25260 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DDE73_25280 ENOG4105C0D helicase DDE73_25365 ENOG4107R6U sodium dicarboxylate symporter DDE73_25400 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DDE73_25405 ENOG4105C3R Methionine synthase DDE73_25415 ENOG4105C28 cystathionine DDE73_25420 ENOG4105C28 cystathionine DDE73_25440 ENOG4105C5X domain protein DDE73_25450 ENOG4105DKQ ROK family DDE73_25460 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DDE73_25480 ENOG4108UTW Plays a role in the regulation of phosphate uptake DDE73_25485 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DDE73_25490 ENOG4105C8U phosphate abc transporter DDE73_25495 ENOG4105C8U phosphate abc transporter DDE73_25500 ENOG4105EXS phosphate abc transporter DDE73_25505 ENOG4107RF6 penicillin-binding protein DDE73_25515 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DDE73_25540 ENOG4105N80 Ferric uptake regulator, Fur family DDE73_25550 ENOG4105FDK ABC transporter DDE73_25555 ENOG4108JYZ YitT family DDE73_25560 ENOG41069ZM Protein of unknown function (DUF2624) DDE73_25585 ENOG4105EGD dinuclear metal center protein, YbgI family DDE73_25600 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDE73_25605 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DDE73_25630 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DDE73_25635 ENOG4105KG3 cytidine deaminase DDE73_25640 ENOG4107YR5 Diacylglycerol kinase DDE73_25645 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DDE73_25650 ENOG4105CTJ Metal Dependent Phosphohydrolase DDE73_25655 ENOG4105C9A Phoh family DDE73_25665 ENOG41068P3 sporulation protein YqfC DDE73_25675 ENOG4105KTH gatB Yqey DDE73_25685 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DDE73_25690 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DDE73_25720 ENOG4105CSA Coproporphyrinogen iii oxidase DDE73_25725 ENOG4105KVH Transcriptional regulator DDE73_25750 ENOG4105TQK DNA polymerase iii, delta' subunit DDE73_25760 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DDE73_25765 ENOG4108UK2 deaminase DDE73_25770 ENOG4105KQC Competence protein DDE73_25780 ENOG4105DXX methyltransferase DDE73_25790 ENOG4108WF2 Metal Dependent Phosphohydrolase DDE73_25800 ENOG410812S Rna-binding protein DDE73_25810 ENOG4105CQW ribosome biogenesis GTPase YqeH DDE73_25815 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DDE73_25830 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDE73_25850 ENOG4108TVJ Nitroreductase DDE73_25865 ENOG4105G6Z alkaline phosphatase DDE73_25870 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DDE73_25875 ENOG4108MUZ hydrolase DDE73_25915 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DDE73_25920 ENOG4105MIR Phenylalanine 4-monooxygenase DDE73_25930 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DDE73_25975 ENOG4105S6R Iron-hydroxamate transporter permease subunit DDE73_25980 ENOG4108V5C ABC transporter DDE73_25995 ENOG4108EKI Dehydrogenase DDE73_26000 ENOG4105C28 cystathionine DDE73_26030 ENOG4107XRG penicillin-binding protein DDE73_26040 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DDE73_26050 ENOG4105CFP Peptidase U32 DDE73_26055 ENOG4105XYU peptidase (U32 family) DDE73_26060 ENOG4108VQJ O-methyltransferase DDE73_26065 ENOG4105HHA aminodeoxychorismate lyase DDE73_26085 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DDE73_26095 ENOG4105C02 permease DDE73_26110 ENOG41060CR DDE73_26115 ENOG4105C7H Helicase, RecD TraA family DDE73_26125 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DDE73_26130 ENOG4105C3J Cysteine desulfurase DDE73_26140 ENOG4105D1H recombination factor protein RarA DDE73_26145 ENOG4108VCI transcription factor, rsfa family DDE73_26155 ENOG4105CUZ uba thif-type nad fad binding protein DDE73_26165 ENOG4105CUT histidyl-tRNA synthetase DDE73_26170 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DDE73_26175 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DDE73_26185 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DDE73_26190 ENOG41076HS cation diffusion facilitator family transporter DDE73_26195 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DDE73_26205 ENOG4105CKP Polysaccharide Biosynthesis Protein DDE73_26210 ENOG4108QG2 Membrane DDE73_26220 ENOG4105VIE preprotein translocase, subunit YajC DDE73_26235 ENOG41061AI Protein of unknown function (DUF2905) DDE73_26250 ENOG4108HUF Transporter DDE73_26275 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DDE73_26280 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DDE73_26285 ENOG4108IYU L-aspartate oxidase DDE73_26300 ENOG4108RPX mosc domain containing protein DDE73_26305 ENOG4105CQC Prephenate dehydratase DDE73_26325 ENOG4105EWM Histidine kinase DDE73_26335 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DDE73_26355 ENOG4105C03 ribonuclease DDE73_26370 ENOG4107QMS site-determining protein DDE73_26385 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DDE73_26390 ENOG4105DFF Rod shape-determining protein mreb DDE73_26410 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DDE73_26415 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DDE73_26425 ENOG41068KH stage VI sporulation protein D DDE73_26435 ENOG4105D52 delta-aminolevulinic acid dehydratase DDE73_26460 ENOG4105K56 Transcriptional regulator DDE73_26480 ENOG4108IUQ atp-dependent protease DDE73_26505 ENOG4108QCI YvbH-like oligomerisation region DDE73_26525 ENOG4105M59 Phosphodiesterase, mj0936 family DDE73_26530 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DDE73_26540 ENOG4108XJQ germination protein DDE73_26550 ENOG4108PCX Major Facilitator DDE73_26560 ENOG4105KBX Transcriptional regulator, TetR family DDE73_26570 ENOG4105PFC Transcriptional regulator DDE73_26580 ENOG4105DZC cytosine deaminase DDE73_26585 ENOG41067S9 phage shock protein C, PspC DDE73_26590 ENOG4108JCI Transcriptional regulator DDE73_26600 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DDE73_26605 ENOG4108Z40 Transcriptional regulator DDE73_26610 ENOG4105RHA ABC transporter, permease DDE73_26615 ENOG4108IUX (ABC) transporter DDE73_26620 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DDE73_26625 ENOG4105ER2 Ompa motb domain protein DDE73_26630 ENOG4105E14 MotA TolQ exbB proton channel DDE73_26640 ENOG4108VXD carboxy-peptidase DDE73_26650 ENOG4105E33 succinate dehydrogenase DDE73_26660 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DDE73_26670 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DDE73_26675 ENOG4105K63 Thioredoxin DDE73_26680 ENOG4105C10 Electron transfer flavoprotein DDE73_26685 ENOG4105BZJ Electron transfer flavoprotein DDE73_26690 ENOG41060WC Enoyl-CoA hydratase DDE73_26695 ENOG4107Z3H Transcriptional regulator, TetR family DDE73_26700 ENOG4105CEY Amp-dependent synthetase and ligase DDE73_26710 ENOG4105J76 Periplasmic binding protein DDE73_26715 ENOG4105S6R Iron-hydroxamate transporter permease subunit DDE73_26765 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DDE73_26775 ENOG4105DR4 Methyltransferase DDE73_26785 ENOG4105KFN sortase, SrtB family DDE73_26790 ENOG4105E0A ABC, transporter DDE73_26815 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DDE73_26825 ENOG4105FE9 pseudouridine synthase DDE73_26835 ENOG4105DCG PHP domain protein DDE73_26850 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DDE73_26870 ENOG4105C5S asparaginyl-tRNA synthetase DDE73_26875 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DDE73_26885 ENOG4108RWN rrna methyltransferase DDE73_26910 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDE73_26915 ENOG4105CW7 secretion protein, HlyD family DDE73_26920 ENOG4108JGH Tetr family transcriptional regulator DDE73_26925 ENOG4105CN9 Peptidase m42 family protein DDE73_26945 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DDE73_26950 ENOG4105C22 threonyL-tRNA synthetase DDE73_26955 ENOG4108TDW sporulation protein YtxC DDE73_26980 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DDE73_26985 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DDE73_26990 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DDE73_27000 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DDE73_27005 ENOG4105C2M dna polymerase I DDE73_27010 ENOG4105BZU Histidine kinase DDE73_27015 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DDE73_27030 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DDE73_27035 ENOG4108HMX isocitrate dehydrogenase (NADP) DDE73_27040 ENOG4105BZN citrate synthase DDE73_27055 ENOG4108REF Sporulation integral membrane protein ytvi DDE73_27060 ENOG4105FS0 cytoplasmic membrane protein DDE73_27085 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DDE73_27090 ENOG4105C6K Malic enzyme DDE73_27095 ENOG4105C0B DNA polymerase III (alpha subunit) DDE73_27100 ENOG4105VV2 DDE73_27110 ENOG4105SFS phosphoesterase RecJ domain protein DDE73_27135 ENOG4105DC7 peptidase M24 DDE73_27175 ENOG4105Z7P Acetyltransferase (GNAT) family DDE73_27180 ENOG41082W1 Cupin 2, conserved barrel domain protein DDE73_27200 ENOG4107YZX Universal stress protein DDE73_27240 ENOG4108JYZ YitT family DDE73_27260 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DDE73_27270 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DDE73_27275 ENOG4105KBJ sporulation protein ytfj DDE73_27290 ENOG4105EFZ amidohydrolase DDE73_27300 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DDE73_27325 ENOG4105RQF LysR family Transcriptional regulator DDE73_27335 ENOG4105U5Y Transcriptional regulator DDE73_27345 ENOG4105C28 cystathionine DDE73_27370 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DDE73_27375 ENOG4108UW5 maltose o-acetyltransferase DDE73_27385 ENOG4105F1V Acetoin utilization protein DDE73_27390 ENOG4105W87 Cbs domain DDE73_27415 ENOG4108IBT Inherit from COG: transposase DDE73_27465 ENOG41082W1 Cupin 2, conserved barrel domain protein DDE73_27525 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DDE73_27545 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DDE73_27550 ENOG4107JM4 Tetratricopeptide repeat DDE73_27570 ENOG4105K70 DNA-binding protein DDE73_27585 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DDE73_27645 ENOG410645S MarR family Transcriptional regulator DDE73_27695 ENOG4105CVR type I restriction-modification system DDE73_27740 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein DDE73_27785 ENOG4105CFF transcriptional regulator DDE73_27860 ENOG4108QY0 Membrane DDE73_27870 ENOG41069DP small acid-soluble spore protein DDE73_27875 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DDE73_27880 ENOG4108R5S membrane DDE73_27890 ENOG4105E39 Enoyl-CoA hydratase DDE73_27895 ENOG4105K64 Glycosyl transferase, family 2 DDE73_27905 ENOG4108UT6 Transferase hexapeptide repeat containing protein DDE73_27930 ENOG4108IMY Transcriptional regulator DDE73_27960 ENOG4107SET aldo keto reductase DDE73_28040 ENOG4105BZ1 (ABC) transporter DDE73_28090 ENOG4105BZU Histidine kinase DDE73_28130 ENOG4105D4Y metalloprotease DDE73_28150 ENOG4105CHR reductase DDE73_28195 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DDE73_28205 ENOG4105D7V transposase DDE73_28230 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin DDE73_28240 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DDE73_28310 ENOG4105EYF MMPL domain protein DDE73_28390 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) DDE73_28500 ENOG4107Y80 Major Facilitator superfamily DDE73_28520 ENOG4105D7V transposase DDE73_28535 ENOG41085GJ domain protein DDE73_28540 ENOG4105CEP NADH dehydrogenase DDE73_28550 ENOG4105D4Y metalloprotease DDE73_28605 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DDE73_28615 ENOG4108M1A Chitin-binding protein DDE73_28665 ENOG4105CJ1 ABC, transporter DDE73_28715 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DDE73_28720 ENOG4108VQT Alpha beta hydrolase fold protein DDE73_28765 ENOG4105C0W non-ribosomal peptide synthetase DDE73_28770 ENOG4107SQU synthase DDE73_28775 ENOG4105C0W non-ribosomal peptide synthetase DDE73_28775 ENOG4105C0W non-ribosomal peptide synthetase DDE73_28780 ENOG4105C0W non-ribosomal peptide synthetase DDE73_28785 ENOG4107SQU synthase DDE73_28790 ENOG4107SQU synthase DDE73_28795 ENOG4105C0W non-ribosomal peptide synthetase DDE73_28800 ENOG4107SQU synthase DDE73_28805 ENOG4107SQU synthase DDE73_28810 ENOG4107SQU synthase DDE73_28820 ENOG4108KQ6 Enoyl-CoA hydratase DDE73_28825 ENOG4108MGH Enoyl-CoA hydratase DDE73_28830 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DDE73_28835 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase DDE73_28840 ENOG41062T2 Acyl carrier protein DDE73_28845 ENOG4107SQU synthase DDE73_28845 ENOG4107SQU synthase DDE73_28850 ENOG4105C0W non-ribosomal peptide synthetase DDE73_28855 ENOG4105C0W non-ribosomal peptide synthetase DDE73_28860 ENOG4105C0W non-ribosomal peptide synthetase DDE73_28865 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DDE73_28875 ENOG4107QKG PfaD family DDE73_28880 ENOG4108151 Beta-lactamase domain protein DDE73_28955 ENOG4108594 Permease of the drug metabolite transporter DDE73_28960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DDE73_28970 ENOG4105DUX Transporter DDE73_29005 ENOG4105KRN Transcriptional regulator, abrb family DDE73_29050 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) DDE73_29055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DDE73_29070 ENOG4106ANW SMI1_KNR4 DDE73_29075 ENOG4106BHF DDE73_29470 ENOG4107QZI cell division protein FtsK DDE73_29605 ENOG4108KP7 hydrolase DDE73_29610 ENOG4107QPR SAICAR synthetase DDE73_29620 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DDE73_29625 ENOG4105EMU Dehydrogenase DDE73_29640 ENOG4106DF4 Sigma-70, region 4 DDE73_29645 ENOG4105CN9 Peptidase m42 family protein DDE73_29665 ENOG4107Y80 Major Facilitator superfamily DDE73_29680 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DDE73_29725 ENOG4105DQ6 Transposase DDE73_29745 ENOG4105E4C Lytic transglycosylase catalytic DDE73_29785 ENOG4105BZ1 (ABC) transporter DDE73_29800 ENOG4105CAQ asparagine synthetase DDE73_29805 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DDE73_29830 ENOG4105IIU Aminopeptidase DDE73_29840 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DDE73_29885 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DDE73_29930 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DDE73_29945 ENOG4105KRN Transcriptional regulator, abrb family DDE73_29955 ENOG4105K70 DNA-binding protein DDE73_30065 ENOG4105C19 ABC transporter DDE73_30415 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DDE73_30585 ENOG41075H3 AraC family transcriptional regulator DDE73_30605 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C DDE73_30670 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DDE73_30730 ENOG4105WEF catalase DDE73_30775 ENOG4105C5Y PTS System DDE73_30800 ENOG4105E1K spore germination protein DDE73_30830 ENOG4105CJ1 ABC, transporter DDE73_30840 ENOG4105BZ1 (ABC) transporter DDE73_30850 ENOG4108M1A Chitin-binding protein DDE73_30930 ENOG4105EMD TRANSCRIPTIONal DDE73_30995 ENOG4105D7V transposase DDE73_31010 ENOG4108QXE glycerophosphoryl diester phosphodiesterase