locus-tag class description BtBc_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BtBc_00015 ENOG410848D S4 domain protein YaaA BtBc_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BtBc_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BtBc_00100 ENOG4105ZMH deoxynucleoside kinase BtBc_00110 ENOG4105GTG Isochorismatase BtBc_00115 ENOG4108Z6B deaminase BtBc_00125 ENOG4105C6E dna polymerase iii BtBc_00145 ENOG41067KS pro-sigma K processing BtBc_00180 ENOG4105CXN decarboxylase BtBc_00190 ENOG4105FA2 dna polymerase iii BtBc_00195 ENOG4105MA4 psp1 domain protein BtBc_00205 ENOG41060K3 Methyltransferase BtBc_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BtBc_00220 ENOG4105KRN Transcriptional regulator, abrb family BtBc_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BtBc_00230 ENOG4105F8V Hydrolase, tatD family BtBc_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BtBc_00245 ENOG4105XFA sporulation peptidase YabG BtBc_00250 ENOG4105W42 Veg protein BtBc_00265 ENOG4105DFT pur operon repressor BtBc_00270 ENOG4105KME endoribonuclease L-psp BtBc_00280 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BtBc_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BtBc_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BtBc_00300 ENOG4108JA2 transcriptioN-repair coupling factor BtBc_00305 ENOG4108M14 stage v sporulation protein t BtBc_00315 ENOG4108IY2 MazG family BtBc_00320 ENOG41082I2 s4 domain protein BtBc_00325 ENOG4105VYY sporulation protein yabp BtBc_00340 ENOG41060GV RNA binding s1 domain protein BtBc_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BtBc_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase BtBc_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BtBc_00385 ENOG4105C6T cysteine synthase BtBc_00390 ENOG4105CRQ synthase (Component I) BtBc_00395 ENOG4105DDQ anthranilate synthase BtBc_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BtBc_00405 ENOG4105EEI dihydropteroate synthase BtBc_00410 ENOG4105KRF dihydroneopterin aldolase BtBc_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BtBc_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BtBc_00515 ENOG4108Z0C Uvrb UvrC protein BtBc_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BtBc_00540 ENOG4105CTP PilT protein domain protein BtBc_00545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BtBc_00560 ENOG4105D7W serine acetyltransferase BtBc_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 BtBc_00580 ENOG4105M0M Tetracycline resistance protein BtBc_00585 ENOG4105QIV RNA polymerase BtBc_00595 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BtBc_00620 ENOG4107Y49 methyltransferase BtBc_00635 ENOG4105XPM ribosomal protein BtBc_00740 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BtBc_00765 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BtBc_00775 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BtBc_00785 ENOG41067V7 50S ribosomal protein L36 BtBc_00810 ENOG4108JJB ABC transporter BtBc_00815 ENOG4108JJB ABC transporter BtBc_00820 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BtBc_00825 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BtBc_00850 ENOG4105D1F ATP-binding protein BtBc_00865 ENOG4108NMV polysaccharide deacetylase BtBc_00945 ENOG4105C8B TIGR00159 family BtBc_00950 ENOG4107U5W ybbr family BtBc_00965 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BtBc_00985 ENOG4108PSK reductase BtBc_00990 ENOG4108UMI ABC transporter, permease BtBc_00995 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BtBc_01000 ENOG4105D01 (LipO)protein BtBc_01005 ENOG4105CB2 alcohol dehydrogenase BtBc_01015 ENOG4105IQ5 FAD linked oxidase domain protein BtBc_01030 ENOG4105C2C drug resistance transporter, Bcr CflA BtBc_01060 ENOG4108J59 Extracellular solute-binding protein, family 5 BtBc_01065 ENOG4108J59 Extracellular solute-binding protein, family 5 BtBc_01090 ENOG4105E0C molybdate abc transporter BtBc_01095 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BtBc_01100 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BtBc_01105 ENOG4105EGI Transcriptional regulator BtBc_01120 ENOG4105F6E Acyl-transferase BtBc_01135 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BtBc_01155 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BtBc_01175 ENOG4105C5H ABC transporter BtBc_01185 ENOG4105DEF Extracellular solute-binding protein, family 5 BtBc_01205 ENOG4105EKQ RNA-directed DNA polymerase BtBc_01220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BtBc_01225 ENOG4105C3U ABC transporter BtBc_01230 ENOG4108JQ7 (ABC) transporter BtBc_01235 ENOG4105DQ6 Transposase BtBc_01245 ENOG410667J hydrolase BtBc_01275 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BtBc_01280 ENOG4105ERH Fumarylacetoacetate hydrolase BtBc_01290 ENOG4105CUB amino acid BtBc_01295 ENOG4108SC4 )-transporter BtBc_01300 ENOG4105CPF Cell wall formation (By similarity) BtBc_01305 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BtBc_01330 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BtBc_01335 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BtBc_01345 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BtBc_01445 ENOG4105K8N protein family UPF0079, ATPase BtBc_01450 ENOG41072GX Peptidase M22 Glycoprotease BtBc_01455 ENOG410801F ribosomal-protein-alanine acetyltransferase BtBc_01460 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BtBc_01465 ENOG4105C5H ABC transporter BtBc_01480 ENOG4108TYN CAAX amino terminal protease family protein BtBc_01575 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BtBc_01790 ENOG4105XSJ toxin secretion phage lysis holin BtBc_01815 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BtBc_01825 ENOG4105C7N Xanthine uracil vitamin C permease BtBc_01835 ENOG4105BZU Histidine kinase BtBc_01860 ENOG4107ZXU DSBA oxidoreductase BtBc_01905 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BtBc_01955 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BtBc_01990 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BtBc_01995 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BtBc_02000 ENOG4105C83 adenylosuccinate lyase BtBc_02010 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BtBc_02035 ENOG4108V3E phosphoribosylglycinamide formyltransferase BtBc_02045 ENOG4105C12 Phosphoribosylglycinamide synthetase BtBc_02070 ENOG4105C4R Atp-dependent dna helicase BtBc_02075 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BtBc_02095 ENOG4108W2Y isochorismatase BtBc_02100 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BtBc_02105 ENOG4108UMI ABC transporter, permease BtBc_02110 ENOG4105D01 (LipO)protein BtBc_02125 ENOG410834F Transcriptional regulator BtBc_02130 ENOG4107I77 yiaA/B two helix domain BtBc_02150 ENOG4105CBD Diacylglycerol kinase BtBc_02155 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BtBc_02160 ENOG4108JPW Aminotransferase BtBc_02170 ENOG4105C26 Dehydrogenase BtBc_02175 ENOG4105KPY Small multidrug resistance protein BtBc_02200 ENOG4105D9N nucleoside BtBc_02205 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BtBc_02215 ENOG4108W15 Protein of unknown function (DUF1456) BtBc_02230 ENOG4105DTQ mandelate racemase muconate lactonizing BtBc_02260 ENOG4105D3R alkyl hydroperoxide reductase BtBc_02265 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BtBc_02270 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BtBc_02275 ENOG4107W7X Aldolase BtBc_02280 ENOG4105EHG Permease protein BtBc_02285 ENOG4105DQ5 transport system permease protein BtBc_02290 ENOG4108V5C ABC transporter BtBc_02295 ENOG4105CAY ferredoxin--nadp reductase BtBc_02310 ENOG4106UIA BtBc_02315 ENOG4106UIA BtBc_02330 ENOG4105BZU Histidine kinase BtBc_02350 ENOG410756H nucleotidyltransferase BtBc_02355 ENOG4105D2S major facilitator superfamily BtBc_02380 ENOG4105E5Q amino acid AbC transporter BtBc_02385 ENOG4105EAB amino acid AbC transporter BtBc_02395 ENOG4105C8Q Methyl-accepting chemotaxis BtBc_02410 ENOG4105DBV ornithine carbamoyltransferase BtBc_02420 ENOG4105C5B carbamate kinase BtBc_02425 ENOG4108W63 CRP FNR family transcriptional regulator BtBc_02455 ENOG4105CI1 PTS System BtBc_02470 ENOG4105C9U ATP-dependent DNA helicase RecQ BtBc_02485 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BtBc_02505 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BtBc_02545 ENOG41062JF Transcriptional regulator BtBc_02560 ENOG4105DEU major facilitator superfamily BtBc_02575 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BtBc_02590 ENOG4108N0M stress protein BtBc_02595 ENOG4106FN3 tellurium resistance protein BtBc_02600 ENOG4106FN3 tellurium resistance protein BtBc_02605 ENOG4107TS3 membrane protein, TerC BtBc_02610 ENOG4108TTB tellurium resistance protein BtBc_02625 ENOG41068PA UPF0435 protein BtBc_02630 ENOG4105KJF protein tyrosine phosphatase BtBc_02640 ENOG4107U9T Pfam:Ribonuclease_BN BtBc_02645 ENOG4105C59 p-type ATPase BtBc_02670 ENOG4107ZTW SNARE associated Golgi BtBc_02685 ENOG410606W general stress protein BtBc_02690 ENOG4105UPD Calcium Proton BtBc_02725 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BtBc_02730 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BtBc_02740 ENOG4108JUB Transcriptional regulator BtBc_02750 ENOG4108IQI permease BtBc_02785 ENOG4108A04 Beta-lactamase BtBc_02800 ENOG4105CKK Glycosyl transferase, family 2 BtBc_02805 ENOG4107QQG Dehydrogenase BtBc_02810 ENOG4105C3I Nad-dependent epimerase dehydratase BtBc_02825 ENOG4105F1A Pyruvate formate-lyase BtBc_02830 ENOG4108QBV Monogalactosyldiacylglycerol synthase BtBc_02845 ENOG4105CI2 imidazolone-5-propionate hydrolase BtBc_02850 ENOG4105ECP epimerase BtBc_02880 ENOG41067AE Membrane-bound metal-dependent hydrolase BtBc_02885 ENOG4105CEN a g-specific adenine glycosylase BtBc_02890 ENOG4106BXE BtBc_02910 ENOG4105BZ1 (ABC) transporter BtBc_02915 ENOG4107NBY Membrane BtBc_02920 ENOG4105CBC glutamate synthase BtBc_02930 ENOG4108IUW ABC transporter BtBc_02950 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BtBc_02955 ENOG4105G5W regulator Fur family BtBc_03065 ENOG4105CDY transcriptional regulatory protein BtBc_03075 ENOG4108JQC penicillin-binding protein 1A BtBc_03080 ENOG4108R9S DSBA oxidoreductase BtBc_03090 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BtBc_03100 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BtBc_03110 ENOG4105CYN Serine protein kinase BtBc_03125 ENOG4105C94 Transporter BtBc_03140 ENOG4105DZ6 Band 7 protein BtBc_03150 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BtBc_03155 ENOG4108V9W transcriptional regulatory protein BtBc_03160 ENOG4105D4T Citrate transporter BtBc_03185 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BtBc_03190 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BtBc_03195 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BtBc_03200 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BtBc_03205 ENOG4105BZ7 extracellular solute-binding protein family 1 BtBc_03210 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BtBc_03215 ENOG4108STX response regulator BtBc_03220 ENOG4105US7 Histidine kinase BtBc_03245 ENOG4108MRH transcriptional regulatory protein BtBc_03255 ENOG4105C6K Malic enzyme BtBc_03265 ENOG4108UZ3 Transporter BtBc_03270 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BtBc_03280 ENOG4105BZU Histidine kinase BtBc_03285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_03300 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BtBc_03305 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BtBc_03310 ENOG4108JB9 formate dehydrogenase BtBc_03330 ENOG4105CUB amino acid BtBc_03345 ENOG4105C59 p-type ATPase BtBc_03350 ENOG4105DAP Nicotinate phosphoribosyltransferase BtBc_03385 ENOG41073R8 VanW family BtBc_03390 ENOG4108KGH TRANSCRIPTIONal BtBc_03395 ENOG4105D9N nucleoside BtBc_03410 ENOG4105EKQ RNA-directed DNA polymerase BtBc_03420 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BtBc_03425 ENOG4105C37 (CBS) domain BtBc_03430 ENOG4108IJ0 Aspartate ammonia-lyase BtBc_03435 ENOG4105DAA L-lactate BtBc_03460 ENOG4105DUX Transporter BtBc_03465 ENOG4108MES Periplasmic binding protein BtBc_03470 ENOG4105DQ5 transport system permease protein BtBc_03475 ENOG4108IHU transport system permease protein BtBc_03480 ENOG4105E0A ABC, transporter BtBc_03485 ENOG4105DMQ Methyltransferase BtBc_03490 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BtBc_03495 ENOG4105EXW epimerase dehydratase BtBc_03505 ENOG4107T89 von Willebrand factor, type A BtBc_03510 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BtBc_03515 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BtBc_03525 ENOG4105BZU Histidine kinase BtBc_03530 ENOG4105D5Q Arginine ornithine antiporter BtBc_03535 ENOG4107414 GntR family transcriptional regulator BtBc_03540 ENOG4105C5Y PTS System BtBc_03545 ENOG4105CG3 alpha amylase, catalytic region BtBc_03560 ENOG4105E1K spore germination protein BtBc_03565 ENOG4105CRN Aminoglycoside phosphotransferase BtBc_03570 ENOG4105BZG amino acid carrier protein BtBc_03580 ENOG4105CDA abc transporter atp-binding protein BtBc_03585 ENOG4105CT1 (ABC) transporter BtBc_03590 ENOG4105EAD ABC transporter BtBc_03595 ENOG4105DRP amino acid AbC transporter BtBc_03600 ENOG4108IQI permease BtBc_03615 ENOG4105GFR rna polymerase sigma factor BtBc_03625 ENOG4105D29 Helix-turn-helix type 11 domain protein BtBc_03630 ENOG4105NAE bifunctional deaminase-reductase domain protein BtBc_03635 ENOG4105BZU Histidine kinase BtBc_03655 ENOG41068KF Universal stress protein BtBc_03665 ENOG4105CXY transporter BtBc_03670 ENOG41067TZ transcriptional regulator, MarR family BtBc_03675 ENOG4105C0R drug resistance transporter emrb qaca subfamily BtBc_03680 ENOG4105ETE Transcriptional regulator (LacI family BtBc_03685 ENOG4108RVA ribokinase BtBc_03695 ENOG4105C2J ABC transporter BtBc_03700 ENOG4105CNN ABC, transporter BtBc_03705 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BtBc_03710 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BtBc_03745 ENOG4105DQ6 Transposase BtBc_03760 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BtBc_03775 ENOG4108IMY Transcriptional regulator BtBc_03905 ENOG4105CAR Terminase, large subunit BtBc_03915 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BtBc_04005 ENOG4105CNU cell division protein FtsK BtBc_04045 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BtBc_04050 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BtBc_04055 ENOG41069ER domain protein BtBc_04060 ENOG4105VZ8 Transcriptional regulator BtBc_04065 ENOG4107D63 BtBc_04080 ENOG4105DUX Transporter BtBc_04100 ENOG4105C85 amino acid BtBc_04105 ENOG4105C7N Xanthine uracil vitamin C permease BtBc_04120 ENOG4105MA6 gCN5-related N-acetyltransferase BtBc_04140 ENOG4105CCU oxidase (Subunit III) BtBc_04145 ENOG4105BZ9 Cytochrome C oxidase, subunit I BtBc_04150 ENOG4105E2S oxidase) subunit II BtBc_04170 ENOG4106CAD Protein of unknown function (DUF3311) BtBc_04175 ENOG4105E1V na solute symporter BtBc_04190 ENOG4108NHD germination protein BtBc_04195 ENOG4105CE1 Ferrous iron transport protein b BtBc_04200 ENOG4105CE1 Ferrous iron transport protein b BtBc_04205 ENOG4105CE1 Ferrous iron transport protein b BtBc_04210 ENOG4105CVA phosphate BtBc_04215 ENOG4105C8U phosphate abc transporter BtBc_04220 ENOG4105E2Z phosphate ABC transporter (Permease BtBc_04345 ENOG41080XQ Signal transduction protein with cbs domains BtBc_04365 ENOG4105ETU transcriptional activator (TenA BtBc_04375 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BtBc_04385 ENOG4108VEU Thiamine monophosphate synthase BtBc_04390 ENOG41080HI glycine oxidase BtBc_04405 ENOG4105D06 uba thif-type nad fad binding protein BtBc_04410 ENOG4105DWF phosphomethylpyrimidine kinase BtBc_04485 ENOG4105C19 ABC transporter BtBc_04495 ENOG4105C7N Xanthine uracil vitamin C permease BtBc_04505 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BtBc_04520 ENOG4105K63 Thioredoxin BtBc_04540 ENOG4108B31 Spore germination protein BtBc_04555 ENOG4105DQ6 Transposase BtBc_04570 ENOG4107Y03 Nitroreductase BtBc_04575 ENOG4105ED1 spovr family BtBc_04585 ENOG4108TCS Glutamyl endopeptidase BtBc_04595 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BtBc_04600 ENOG4105XTG Pfam:DUF156 BtBc_04605 ENOG4105VFE sira family BtBc_04610 ENOG4107TPS domain protein BtBc_04615 ENOG4105VFE sira family BtBc_04630 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BtBc_04635 ENOG41087NI Sulfite exporter TauE/SafE BtBc_04645 ENOG4108KGH TRANSCRIPTIONal BtBc_04670 ENOG4105EMD TRANSCRIPTIONal BtBc_04675 ENOG4105VCP PTS System BtBc_04680 ENOG4105VZJ PTS System BtBc_04705 ENOG41069ER domain protein BtBc_04710 ENOG4107RBB ABC transporter, permease BtBc_04715 ENOG4105C19 ABC transporter BtBc_04745 ENOG4105WEF catalase BtBc_04780 ENOG4107T5V SNARE associated Golgi BtBc_04810 ENOG4105CUB amino acid BtBc_04815 ENOG4107RWR Sodium hydrogen exchanger BtBc_04825 ENOG4106KNT transcriptional regulator BtBc_04865 ENOG4108YXU transcriptional regulator AsnC family BtBc_04870 ENOG4105CH7 arginosuccinase BtBc_04875 ENOG4105UBK short-chain dehydrogenase reductase BtBc_04885 ENOG4105KPY Small multidrug resistance protein BtBc_04920 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BtBc_04925 ENOG4105E5W Transporter BtBc_04935 ENOG4107RKG DJ-1/PfpI family BtBc_04940 ENOG4105CH6 catalase BtBc_04950 ENOG4105D5Q Arginine ornithine antiporter BtBc_04955 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BtBc_04965 ENOG4105C26 Dehydrogenase BtBc_04970 ENOG4105BZ1 (ABC) transporter BtBc_04975 ENOG4105BZ1 (ABC) transporter BtBc_04985 ENOG4105DRP amino acid AbC transporter BtBc_04990 ENOG4105CDA abc transporter atp-binding protein BtBc_05005 ENOG410839P BtBc_05040 ENOG4107FQX Alpha-acetolactate decarboxylase BtBc_05050 ENOG4108VX5 3-methyladenine DNA glycosylase BtBc_05065 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BtBc_05070 ENOG4105D4P Coproporphyrinogen iii oxidase BtBc_05075 ENOG4105CEY Amp-dependent synthetase and ligase BtBc_05090 ENOG4105CHH sulfate transporter BtBc_05115 ENOG4105CGU Enoyl-CoA hydratase BtBc_05135 ENOG4105DER m42 family BtBc_05180 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BtBc_05190 ENOG4108JQ7 (ABC) transporter BtBc_05225 ENOG4105DQ6 Transposase BtBc_05245 ENOG4108IBT Inherit from COG: transposase BtBc_05295 ENOG4105CSH Transporter BtBc_05305 ENOG4108MRH transcriptional regulatory protein BtBc_05315 ENOG4105M6F mutator MutT protein BtBc_05330 ENOG4105CDU Replicative dna helicase BtBc_05345 ENOG4105CDU Replicative dna helicase BtBc_05370 ENOG4108Z86 Glutamine amidotransferase BtBc_05385 ENOG41087YS Phage shock protein A BtBc_05395 ENOG4105C0R drug resistance transporter emrb qaca subfamily BtBc_05410 ENOG4105D9U N-acetyltransferase BtBc_05425 ENOG4105DQ6 Transposase BtBc_05465 ENOG4107VUZ BtBc_05490 ENOG4105EKQ RNA-directed DNA polymerase BtBc_05505 ENOG4105F6J Alpha beta hydrolase fold BtBc_05540 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BtBc_05560 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BtBc_05610 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BtBc_05625 ENOG4105DQ6 Transposase BtBc_05630 ENOG4105F27 Major Facilitator BtBc_05635 ENOG4105WAB arsR family transcriptional regulator BtBc_05655 ENOG4108NIW Leucine export protein LeuE BtBc_05660 ENOG4105CMT Dihydroxyacetone kinase BtBc_05770 ENOG4105WN5 stage II sporulation protein BtBc_05780 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BtBc_05790 ENOG4108MJI response regulator BtBc_05795 ENOG4105BZU Histidine kinase BtBc_05800 ENOG4105BZU Histidine kinase BtBc_05820 ENOG4105K8R UPF0145 protein BtBc_05835 ENOG4105C6F GntR Family Transcriptional Regulator BtBc_05845 ENOG4107QHE Choloylglycine hydrolase BtBc_05865 ENOG4107VRP DNA repair exonuclease BtBc_05870 ENOG4106D4I domain protein BtBc_05930 ENOG4105F0F Oxalate decarboxylase BtBc_05935 ENOG41067QW Transcriptional regulator BtBc_05940 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BtBc_05955 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BtBc_05970 ENOG4105EMN RNA polymerase sigma factor BtBc_05980 ENOG4105CNI cell division protein FtsW BtBc_05985 ENOG4105EEM helicase BtBc_05990 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BtBc_06015 ENOG4105K59 histidine triad (HIT) protein BtBc_06045 ENOG410905X membrane-flanked domain protein BtBc_06050 ENOG4105CKV Membrane BtBc_06090 ENOG410905X membrane-flanked domain protein BtBc_06095 ENOG4105CKV Membrane BtBc_06100 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BtBc_06105 ENOG4105BZ4 penicillin-binding protein BtBc_06115 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BtBc_06120 ENOG4105C1Q protoporphyrinogen oxidase BtBc_06145 ENOG4105NA0 Transcriptional regulator BtBc_06160 ENOG4105ECB domain protein BtBc_06160 ENOG4105ECB domain protein BtBc_06190 ENOG4108MK9 spermidine N(1)-acetyltransferase BtBc_06200 ENOG4106AXD BtBc_06205 ENOG4108RQ5 Beta-lactamase domain-containing protein BtBc_06210 ENOG4105DF9 Lipoate-protein, ligase BtBc_06220 ENOG4105CEY Amp-dependent synthetase and ligase BtBc_06230 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BtBc_06235 ENOG4108I5D sulfate abc transporter BtBc_06240 ENOG4105ECW sulfate abc transporter BtBc_06245 ENOG4108IJ6 ABC transporter BtBc_06320 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BtBc_06330 ENOG4105ENX hydrolase BtBc_06335 ENOG4107RN3 metallophosphoesterase BtBc_06340 ENOG4107TVP HD domain protein BtBc_06350 ENOG4108AEY RNA polymerase sigma factor BtBc_06355 ENOG41086D8 Transcriptional regulator BtBc_06370 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BtBc_06390 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BtBc_06395 ENOG4105C8Q Methyl-accepting chemotaxis BtBc_06400 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) BtBc_06410 ENOG4107QP3 malate synthase g BtBc_06430 ENOG4105VEQ Cold shock protein BtBc_06510 ENOG4105ERH Fumarylacetoacetate hydrolase BtBc_06520 ENOG4105C8Y Acetylornithine aminotransferase BtBc_06535 ENOG4105CAQ asparagine synthetase BtBc_06550 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BtBc_06645 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BtBc_06665 ENOG41085W3 Transposase BtBc_06700 ENOG41085W3 Transposase BtBc_06770 ENOG4105XSJ toxin secretion phage lysis holin BtBc_06775 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BtBc_06800 ENOG4105CAQ asparagine synthetase BtBc_06805 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BtBc_06810 ENOG4105CH6 catalase BtBc_06845 ENOG4105BZU Histidine kinase BtBc_06860 ENOG4108VPT UPF0234 protein BtBc_06865 ENOG4105QNR S1 RNA binding domain protein BtBc_06880 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BtBc_06885 ENOG4107AYK membrAne BtBc_06890 ENOG41073B9 BtBc_06900 ENOG4108KP7 hydrolase BtBc_06910 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BtBc_06935 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BtBc_06940 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BtBc_06955 ENOG4105C31 Tryptophanyl-tRNA synthetase BtBc_06975 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BtBc_06980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BtBc_06990 ENOG4108JQ7 (ABC) transporter BtBc_06995 ENOG4105UQX Mate efflux family protein BtBc_07015 ENOG4108ZCF integral membrane protein BtBc_07025 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BtBc_07035 ENOG4105DPN Oligoendopeptidase f BtBc_07045 ENOG4108Z18 K06886 hemoglobin BtBc_07050 ENOG4105MIX Adenylate cyclase BtBc_07055 ENOG4106EFP UPF0738 protein BtBc_07065 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BtBc_07070 ENOG4105EMS pseudouridine synthase BtBc_07090 ENOG4105K64 Glycosyl transferase, family 2 BtBc_07110 ENOG4107TVC Glycosyl transferase, family 2 BtBc_07130 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BtBc_07135 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BtBc_07145 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BtBc_07195 ENOG4108ZMI UPF0477 protein BtBc_07225 ENOG4105CK7 Sodium proline symporter BtBc_07230 ENOG4105CRQ synthase (Component I) BtBc_07235 ENOG4105DDQ anthranilate synthase BtBc_07245 ENOG4105DK0 Indole-3-glycerol phosphate synthase BtBc_07320 ENOG4105DQ6 Transposase BtBc_07325 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BtBc_07345 ENOG4105C7S Dehydrogenase BtBc_07350 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BtBc_07355 ENOG4105VZ8 Transcriptional regulator BtBc_07385 ENOG4105DQ6 Transposase BtBc_07400 ENOG4108IUX (ABC) transporter BtBc_07405 ENOG4105RHA ABC transporter, permease BtBc_07425 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BtBc_07435 ENOG4105DZ1 carboxypeptidase BtBc_07440 ENOG4105VFR signal peptidase BtBc_07475 ENOG4105C26 Dehydrogenase BtBc_07480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BtBc_07485 ENOG4105F38 ABC transporter, permease BtBc_07490 ENOG4105D38 putrescine abc transporter BtBc_07495 ENOG4107RUE extracellular solute-binding protein family 1 BtBc_07505 ENOG4105EYF MMPL domain protein BtBc_07515 ENOG4108YBP pseudouridine synthase BtBc_07525 ENOG4105K4I Scp-like extracellular BtBc_07530 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BtBc_07535 ENOG4105CQB FAD linked oxidase domain protein BtBc_07550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_07555 ENOG4105BZU Histidine kinase BtBc_07560 ENOG4105JXH GntR family transcriptional regulator BtBc_07580 ENOG4106A3R peptidase BtBc_07590 ENOG4108QTI )-transporter BtBc_07595 ENOG4107TS3 membrane protein, TerC BtBc_07600 ENOG4105CZN Potassium uptake protein BtBc_07605 ENOG410681C small acid-soluble spore protein BtBc_07610 ENOG4108Z7G MaoC domain protein dehydratase BtBc_07630 ENOG4105CHR reductase BtBc_07660 ENOG4105C4Y ABC transporter BtBc_07665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BtBc_07670 ENOG4107RCV ABC transporter, permease BtBc_07690 ENOG4105E98 transcriptional regulator DeoR family BtBc_07705 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BtBc_07715 ENOG4105PXI polysaccharide deacetylase BtBc_07725 ENOG4105BZU Histidine kinase BtBc_07730 ENOG41090MY MarR family Transcriptional regulator BtBc_07740 ENOG4106DF1 BtBc_07750 ENOG4105BZU Histidine kinase BtBc_07755 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BtBc_07760 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BtBc_07765 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BtBc_07805 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BtBc_07810 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BtBc_07825 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BtBc_07830 ENOG4105CZV ABC transporter BtBc_07840 ENOG4105CJ1 ABC, transporter BtBc_07880 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BtBc_07885 ENOG4105EA8 2-Nitropropane dioxygenase BtBc_07890 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BtBc_07900 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BtBc_07925 ENOG4105NQC Flavodoxin BtBc_07990 ENOG4105CZN Potassium uptake protein BtBc_07995 ENOG41063Y9 BtBc_08000 ENOG4105KBJ sporulation protein ytfj BtBc_08020 ENOG4105CM2 brancheD-chain amino acid aminotransferase BtBc_08025 ENOG4105C7K acetolactate synthase BtBc_08030 ENOG4108ZP8 Acetolactate synthase small subunit BtBc_08035 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BtBc_08050 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BtBc_08065 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BtBc_08070 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BtBc_08075 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BtBc_08080 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BtBc_08085 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BtBc_08090 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BtBc_08105 ENOG4107RVV histidinol phosphate phosphatase, hisj family BtBc_08120 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BtBc_08125 ENOG4105E0M Sulfatase BtBc_08135 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BtBc_08150 ENOG4107S4M Sulfate adenylate transferase BtBc_08155 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BtBc_08160 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BtBc_08170 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BtBc_08175 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BtBc_08180 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BtBc_08185 ENOG4105C8J )-transporter BtBc_08205 ENOG4105DFD Na H antiporter BtBc_08225 ENOG4105ENE Histidine kinase BtBc_08230 ENOG4105WH1 Two component transcriptional regulator luxr family BtBc_08250 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BtBc_08275 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BtBc_08295 ENOG4105CJ3 phosphate transporter BtBc_08300 ENOG4107GRR phosphate transport regulator BtBc_08305 ENOG4105BZ4 penicillin-binding protein BtBc_08320 ENOG4105BZU Histidine kinase BtBc_08325 ENOG4105I3N Conserved Protein BtBc_08340 ENOG4105BZU Histidine kinase BtBc_08370 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BtBc_08375 ENOG4105DZ1 carboxypeptidase BtBc_08380 ENOG4108JIC nucleoside recognition domain protein BtBc_08390 ENOG4105FE9 pseudouridine synthase BtBc_08395 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BtBc_08400 ENOG4107TWT Cytochrome c biogenesis protein BtBc_08405 ENOG4105CRE cytochrome C BtBc_08410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_08415 ENOG4105BZU Histidine kinase BtBc_08420 ENOG4108WBT adenosyltransferase BtBc_08435 ENOG4108SAX Membrane BtBc_08450 ENOG4105C9U ATP-dependent DNA helicase RecQ BtBc_08455 ENOG4105I7S Abortive infection protein BtBc_08465 ENOG4107RGJ metallophosphoesterase BtBc_08470 ENOG4108XDN Transcriptional regulator BtBc_08475 ENOG4108S6Z Negative regulator of genetic competence BtBc_08500 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BtBc_08505 ENOG4107RB3 L-asparaginase BtBc_08520 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BtBc_08535 ENOG4105S2F BtBc_08540 ENOG41065D1 BtBc_08570 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BtBc_08585 ENOG4105XXQ heptaprenyl diphosphate synthase component I BtBc_08595 ENOG4105EAH synthase BtBc_08600 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BtBc_08605 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BtBc_08625 ENOG41068YB TPR repeat-containing protein BtBc_08640 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BtBc_08645 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BtBc_08680 ENOG4105DQ6 Transposase BtBc_08690 ENOG4108JYZ YitT family BtBc_08695 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BtBc_08710 ENOG4105FJR Lmbe family BtBc_08715 ENOG4105CPK Glycosyl transferase (Group 1 BtBc_08735 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BtBc_08750 ENOG4105DVT helicase BtBc_08755 ENOG4105YAC BtBc_08775 ENOG4105CSM endonuclease III BtBc_08785 ENOG4105BZ4 penicillin-binding protein BtBc_08825 ENOG4106F55 Protein of unknown function (DUF1273) BtBc_08840 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BtBc_08850 ENOG4105DVT helicase BtBc_08855 ENOG4105CTD carboxy-peptidase BtBc_08865 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BtBc_08870 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BtBc_08875 ENOG4105C2W permease BtBc_08880 ENOG4105DHF Membrane BtBc_08885 ENOG410890F Dynamin family BtBc_08895 ENOG4108W0I acetyltransferase BtBc_08905 ENOG4105KHC sulfurtransferase BtBc_08960 ENOG4105HTX biosynthesis protein BtBc_08990 ENOG4105CPK Glycosyl transferase (Group 1 BtBc_09005 ENOG4108SZE gCN5-related N-acetyltransferase BtBc_09025 ENOG41081VK Ribonuclease BtBc_09090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BtBc_09100 ENOG4107RWR Sodium hydrogen exchanger BtBc_09105 ENOG4105CN5 Metallo-Beta-Lactamase BtBc_09110 ENOG4108Z5V transcriptional regulator, merr family BtBc_09120 ENOG4105H67 Protein of unknown function (DUF421) BtBc_09125 ENOG41080C8 DUF218 domain BtBc_09165 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BtBc_09175 ENOG4107R0U MotA TolQ exbB proton channel BtBc_09180 ENOG4105ER2 Ompa motb domain protein BtBc_09185 ENOG4107YTP response regulator receiver protein BtBc_09190 ENOG4105CBS Chea signal transduction histidine kinase BtBc_09195 ENOG4105DD5 Flagellar motor switch protein BtBc_09210 ENOG4105BZU Histidine kinase BtBc_09230 ENOG4105E1Q flagellar hook-associated protein BtBc_09235 ENOG4105DTJ flagellar hook-associated protein BtBc_09255 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BtBc_09260 ENOG4108ZC9 flagellar basal-body rod protein flgc BtBc_09265 ENOG41075Z6 flagellar hook-basal body complex protein fliE BtBc_09270 ENOG4107U2N Flagellar M-ring protein BtBc_09275 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BtBc_09305 ENOG4105BZE flagellar hook protein, FlgE BtBc_09320 ENOG4107R88 Chemotaxis protein (CheV) BtBc_09330 ENOG4105I03 Flagellin BtBc_09335 ENOG4105I03 Flagellin BtBc_09340 ENOG4105I03 Flagellin BtBc_09345 ENOG4105I03 Flagellin BtBc_09350 ENOG4105E4C Lytic transglycosylase catalytic BtBc_09360 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BtBc_09365 ENOG4105DD5 Flagellar motor switch protein BtBc_09375 ENOG4105CN7 Flagellar biosynthetic protein FliP BtBc_09380 ENOG4105VS8 Flagellar biosynthetic protein fliq BtBc_09390 ENOG4105D00 flagellar biosynthetic protein flhB BtBc_09395 ENOG4105D7B Flagellar biosynthesis protein flha BtBc_09400 ENOG4105FZW flagellar biosynthesis regulator FlhF BtBc_09405 ENOG4105KTQ flagellar basal-body rod protein BtBc_09410 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BtBc_09470 ENOG4105DUM transcriptional regulator, lysR family BtBc_09475 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BtBc_09480 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BtBc_09485 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BtBc_09515 ENOG4105CVJ phosphoglycerate mutase BtBc_09525 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BtBc_09530 ENOG41085W3 Transposase BtBc_09550 ENOG4105CAQ asparagine synthetase BtBc_09570 ENOG4105PGM cation diffusion facilitator family transporter BtBc_09580 ENOG4105DRR Transcriptional regulator, GntR family BtBc_09585 ENOG4108UZ3 Transporter BtBc_09595 ENOG4105CKI cobalamin synthesis protein BtBc_09600 ENOG4108PJD permease BtBc_09615 ENOG4105DFD Na H antiporter BtBc_09620 ENOG4105VUF Transcriptional regulator BtBc_09630 ENOG4105C9Q fumarate hydratase class II BtBc_09645 ENOG4107QJQ Mate efflux family protein BtBc_09650 ENOG4105EC3 peptidase S51, dipeptidase E BtBc_09670 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BtBc_09690 ENOG4106BRA Membrane BtBc_09725 ENOG4105CJ1 ABC, transporter BtBc_09750 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BtBc_09765 ENOG4108IJ0 Aspartate ammonia-lyase BtBc_09770 ENOG4105C6K Malic enzyme BtBc_09805 ENOG4105DQ6 Transposase BtBc_09815 ENOG41067QW Transcriptional regulator BtBc_09840 ENOG4105FVX BtBc_09845 ENOG4105E09 nadh pyrophosphatase BtBc_09860 ENOG4105CSR polyphosphate kinase 2 BtBc_09865 ENOG4105U3E Transcriptional regulator BtBc_09875 ENOG4105DXI Major Facilitator superfamily BtBc_09885 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BtBc_09890 ENOG4105EU0 Major facilitator Superfamily BtBc_09895 ENOG4105C6T cysteine synthase BtBc_09915 ENOG4105C8J )-transporter BtBc_09920 ENOG4105X5K response regulator receiver protein BtBc_09925 ENOG4105H67 Protein of unknown function (DUF421) BtBc_09950 ENOG4105CHR reductase BtBc_09955 ENOG4105CM2 brancheD-chain amino acid aminotransferase BtBc_09960 ENOG4105C7K acetolactate synthase BtBc_09970 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BtBc_09975 ENOG4105C01 Dihydroxy-acid dehydratase BtBc_09980 ENOG4105C7B Threonine dehydratase BtBc_10005 ENOG4105C6X Major Facilitator BtBc_10010 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BtBc_10020 ENOG4105DY9 regulatoR BtBc_10025 ENOG4105CYC Transferase BtBc_10030 ENOG4105K5X acetyltransferase BtBc_10050 ENOG41068WN BtBc_10055 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BtBc_10070 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BtBc_10080 ENOG4105C0X amino acid BtBc_10105 ENOG4105K8R UPF0145 protein BtBc_10120 ENOG4107RHR regulatoR BtBc_10130 ENOG4105D9N nucleoside BtBc_10135 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BtBc_10160 ENOG4107RAQ aminopeptidase BtBc_10170 ENOG4107R16 Multicopper oxidase BtBc_10210 ENOG4108T5E Copper resistance protein BtBc_10215 ENOG4105KTB nuclear export factor GLE1 BtBc_10220 ENOG4107RT3 EamA-like transporter family BtBc_10225 ENOG4105GZI Transcriptional regulator BtBc_10230 ENOG4108Z40 Transcriptional regulator BtBc_10235 ENOG4107ZXU DSBA oxidoreductase BtBc_10240 ENOG4108TVJ Nitroreductase BtBc_10255 ENOG4106F5Q Membrane BtBc_10260 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BtBc_10270 ENOG4105CKI cobalamin synthesis protein BtBc_10280 ENOG4105C0Z ABC transporter BtBc_10285 ENOG4108IV0 ABC, transporter BtBc_10290 ENOG4105C32 Amino acid ABC transporter (Permease) BtBc_10300 ENOG4105EGI Transcriptional regulator BtBc_10325 ENOG4105C4M (Ubiquinol oxidase) subunit I BtBc_10330 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BtBc_10335 ENOG4108JJ9 ABC, transporter BtBc_10340 ENOG4108JJ8 (ABC) transporter BtBc_10350 ENOG4105K64 Glycosyl transferase, family 2 BtBc_10360 ENOG4108UT6 Transferase hexapeptide repeat containing protein BtBc_10415 ENOG4105BZ1 (ABC) transporter BtBc_10420 ENOG4105EFI regulatoR BtBc_10425 ENOG4105BZU Histidine kinase BtBc_10435 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BtBc_10440 ENOG4108ZJ4 polysaccharide deacetylase BtBc_10460 ENOG41085W3 Transposase BtBc_10465 ENOG4105D6E homoserine dehydrogenase BtBc_10475 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BtBc_10490 ENOG4108KGH TRANSCRIPTIONal BtBc_10500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BtBc_10505 ENOG4105BZU Histidine kinase BtBc_10510 ENOG4107VMI polysaccharide deacetylase BtBc_10520 ENOG4105KT7 mgtC SapB transporter BtBc_10525 ENOG4105VRR gCN5-related N-acetyltransferase BtBc_10535 ENOG4105D7V transposase BtBc_10565 ENOG4105CEY Amp-dependent synthetase and ligase BtBc_10580 ENOG4108WBH protein TIM barrel BtBc_10585 ENOG4105YWU small acid-soluble spore protein BtBc_10595 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BtBc_10600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BtBc_10650 ENOG4105KRN Transcriptional regulator, abrb family BtBc_10660 ENOG4105YVS arsR family transcriptional regulator BtBc_10665 ENOG4105CPC Aldo Keto reductase BtBc_10670 ENOG4107XZQ multidrug resistance protein BtBc_10680 ENOG4105KAF membrAne BtBc_10705 ENOG4105C8Q Methyl-accepting chemotaxis BtBc_10720 ENOG4108K88 Membrane BtBc_10725 ENOG4108WPJ Ferritin-like domain BtBc_10740 ENOG4105DQ6 Transposase BtBc_10750 ENOG4105DEN Luciferase family BtBc_10765 ENOG4105VMI -acetyltransferase BtBc_10770 ENOG4107QM2 Aldo Keto reductase BtBc_10780 ENOG4105CKI cobalamin synthesis protein BtBc_10790 ENOG4105DSE periplasmic solute binding protein BtBc_10810 ENOG4105EKQ RNA-directed DNA polymerase BtBc_10820 ENOG4105K4T epimerase BtBc_10830 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BtBc_10875 ENOG4107T5V SNARE associated Golgi BtBc_10890 ENOG4108PJD permease BtBc_10900 ENOG4108S4H thioesterase Superfamily protein BtBc_10905 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BtBc_10925 ENOG4105SXS Protein of unknown function (DUF456) BtBc_10930 ENOG4105C37 (CBS) domain BtBc_10945 ENOG4105DQ6 Transposase BtBc_10950 ENOG4105IYK transposase BtBc_10960 ENOG4108Z7R Chaperone CsaA BtBc_10975 ENOG4108ZRV stage ii sporulation protein p BtBc_10985 ENOG4108VXD carboxy-peptidase BtBc_11015 ENOG4108ZRV stage ii sporulation protein p BtBc_11055 ENOG4106050 phage regulatory protein, rha family BtBc_11180 ENOG4105CAR Terminase, large subunit BtBc_11190 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BtBc_11240 ENOG4105EKQ RNA-directed DNA polymerase BtBc_11275 ENOG41085W3 Transposase BtBc_11285 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BtBc_11340 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BtBc_11350 ENOG41087PP glycosyltransferase MGT family BtBc_11355 ENOG4108JYZ YitT family BtBc_11360 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BtBc_11390 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BtBc_11415 ENOG4106PAW secretion accessory protein EsaA YueB BtBc_11425 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) BtBc_11430 ENOG4108MGT Required for secretion of EsxA and EsxB BtBc_11525 ENOG4105KBJ sporulation protein ytfj BtBc_11550 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BtBc_11570 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BtBc_11575 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BtBc_11585 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BtBc_11595 ENOG4105EMN RNA polymerase sigma factor BtBc_11610 ENOG4105CNW domain protein BtBc_11625 ENOG4108V06 Glutathione peroxidase BtBc_11640 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BtBc_11655 ENOG4108IUE nitrate reductase beta subunit BtBc_11660 ENOG4105R3A Nitrate reductase BtBc_11670 ENOG4107V6Q Cyclic nucleotide-binding domain BtBc_11675 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BtBc_11680 ENOG4105D06 uba thif-type nad fad binding protein BtBc_11685 ENOG4105CVM Molybdenum cofactor synthesis domain protein BtBc_11690 ENOG4108ZAF Molybdopterin BtBc_11695 ENOG41067WU Molybdopterin converting factor (Subunit 1) BtBc_11710 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BtBc_11715 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BtBc_11720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BtBc_11725 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BtBc_11730 ENOG4108IFG nitrite reductase, (NAD(P)H) BtBc_11735 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BtBc_11770 ENOG4105MCT stage V sporulation protein S BtBc_11795 ENOG4107TSN permease BtBc_11810 ENOG4108KU9 integrase family BtBc_11815 ENOG4108FPN Integrase BtBc_11840 ENOG4105C5H ABC transporter BtBc_11950 ENOG4108UUM single-stranded DNA-binding protein BtBc_11975 ENOG4107YX5 Pfam:DUF548 BtBc_11980 ENOG4105C75 arginyL-tRNA synthetase BtBc_12005 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BtBc_12025 ENOG4105DQ6 Transposase BtBc_12030 ENOG4105IYK transposase BtBc_12040 ENOG4105C5S asparaginyl-tRNA synthetase BtBc_12045 ENOG4105C8J )-transporter BtBc_12070 ENOG4105CY2 Citrate transporter BtBc_12090 ENOG4105KD7 acetyltransferase BtBc_12100 ENOG4105VMP Transcriptional regulator BtBc_12105 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BtBc_12130 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BtBc_12145 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BtBc_12150 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BtBc_12160 ENOG4107RVG penicillin-binding protein BtBc_12165 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BtBc_12170 ENOG4105E9Q Acyl-transferase BtBc_12175 ENOG4108UT2 hemolysin iii BtBc_12185 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BtBc_12195 ENOG4108RCR degv family BtBc_12205 ENOG4108KF3 Electron transport protein SCO1 SenC BtBc_12210 ENOG4107Y70 Heat shock protein BtBc_12215 ENOG4105CAQ asparagine synthetase BtBc_12235 ENOG4108MES Periplasmic binding protein BtBc_12240 ENOG4105F0I Aminotransferase BtBc_12270 ENOG4105D8X mechanosensitive ion channel BtBc_12275 ENOG4105BZU Histidine kinase BtBc_12280 ENOG4105WH1 Two component transcriptional regulator luxr family BtBc_12285 ENOG4106KNT transcriptional regulator BtBc_12290 ENOG4107ZY0 Phenazine biosynthesis-like protein BtBc_12310 ENOG4105CMG Carbohydrate kinase BtBc_12315 ENOG4105C6Z Gluconate BtBc_12325 ENOG4108YV3 Protein of unknown function (DUF2711) BtBc_12355 ENOG4108IJ8 ABC transporter BtBc_12360 ENOG4105E90 ABC transporter BtBc_12395 ENOG4105C37 (CBS) domain BtBc_12420 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BtBc_12435 ENOG4107S4Y M20 DapE family protein YgeY BtBc_12440 ENOG4108TSC N-acetyltransferase BtBc_12445 ENOG4108JUB Transcriptional regulator BtBc_12450 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BtBc_12490 ENOG410841Q phosphoesterase PA-phosphatase related protein BtBc_12500 ENOG4105SZ6 Thioredoxin BtBc_12535 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BtBc_12600 ENOG4105BZ4 penicillin-binding protein BtBc_12610 ENOG4105CZM Major Facilitator BtBc_12615 ENOG4105W8X HesB YadR YfhF-family protein BtBc_12625 ENOG4105DXD 2-methylcitrate dehydratase BtBc_12630 ENOG4105CR4 methylisocitrate lyase BtBc_12635 ENOG4105C1G acyl-Coa dehydrogenase BtBc_12640 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BtBc_12650 ENOG4105N14 lysine exporter protein LysE YggA BtBc_12655 ENOG4105E39 Enoyl-CoA hydratase BtBc_12670 ENOG4107RFY SbcCD D subunit BtBc_12675 ENOG4105EYH Exonuclease BtBc_12695 ENOG4105FCD Major Facilitator BtBc_12700 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BtBc_12705 ENOG4105E4F Isochorismate synthase BtBc_12710 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BtBc_12715 ENOG4105WQI isochorismatase BtBc_12720 ENOG4105CEY Amp-dependent synthetase and ligase BtBc_12725 ENOG4105WQT MbtH domain protein BtBc_12730 ENOG4105C0R drug resistance transporter emrb qaca subfamily BtBc_12745 ENOG4105K70 DNA-binding protein BtBc_12765 ENOG4105BZG amino acid carrier protein BtBc_12785 ENOG4105FE9 pseudouridine synthase BtBc_12790 ENOG4105C22 threonyL-tRNA synthetase BtBc_12795 ENOG4105C19 ABC transporter BtBc_12835 ENOG41081I9 integral membrane protein BtBc_12845 ENOG4108Y4K DNA-binding transcriptional activator BtBc_12870 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BtBc_12880 ENOG4105EYF MMPL domain protein BtBc_12905 ENOG4105WCN acetyltransferase BtBc_12930 ENOG4105C1Q protoporphyrinogen oxidase BtBc_12940 ENOG41068WN BtBc_12970 ENOG4107V2S Transcriptional regulator BtBc_12975 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BtBc_12995 ENOG4105DND Transcriptional regulator BtBc_13000 ENOG4108RPX mosc domain containing protein BtBc_13015 ENOG4105BZ1 (ABC) transporter BtBc_13020 ENOG4105BZ1 (ABC) transporter BtBc_13045 ENOG4108JCI Transcriptional regulator BtBc_13075 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BtBc_13080 ENOG4108KPJ rna polymerase sigma factor BtBc_13105 ENOG4105F32 YngK protein BtBc_13130 ENOG4105RD7 BadF BadG BcrA BcrD BtBc_13145 ENOG4105C7B Threonine dehydratase BtBc_13150 ENOG4108INS Transcriptional regulator BtBc_13170 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BtBc_13180 ENOG4105C1J atp-dependent rna helicase BtBc_13190 ENOG4108RZE Tetr family transcriptional regulator BtBc_13205 ENOG41088CC tellurite resistance protein tehB BtBc_13215 ENOG4108I0C methyltransferase BtBc_13220 ENOG4107RA9 decarboxylase BtBc_13225 ENOG4105K56 Transcriptional regulator BtBc_13230 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BtBc_13255 ENOG4105CIN aminoacyl-histidine dipeptidase BtBc_13280 ENOG4105KRN Transcriptional regulator, abrb family BtBc_13285 ENOG4105IYK transposase BtBc_13290 ENOG4105DQ6 Transposase BtBc_13300 ENOG4105EJ9 Membrane BtBc_13305 ENOG4105EQK -acetyltransferase BtBc_13340 ENOG4105W8Z 4'-phosphopantetheinyl transferase BtBc_13385 ENOG4105EKQ RNA-directed DNA polymerase BtBc_13395 ENOG4105CJW magnesium transporter BtBc_13470 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BtBc_13480 ENOG4108KDT Molybdate metabolism regulator BtBc_13505 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BtBc_13510 ENOG4108JQ1 Dehydrogenase BtBc_13540 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BtBc_13550 ENOG4105BZU Histidine kinase BtBc_13555 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BtBc_13575 ENOG4105JQZ Methyltransferase BtBc_13585 ENOG4105E0Y RtcB Protein BtBc_13595 ENOG4105K6H D-cysteine desulfhydrase BtBc_13615 ENOG4105C0R drug resistance transporter emrb qaca subfamily BtBc_13620 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BtBc_13700 ENOG4108YXU transcriptional regulator AsnC family BtBc_13705 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BtBc_13710 ENOG4105M4P Tetr family transcriptional regulator BtBc_13715 ENOG4105F27 Major Facilitator BtBc_13720 ENOG41085FC arsR family transcriptional regulator BtBc_13725 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BtBc_13730 ENOG4105D6J arsenicaL-resistance protein BtBc_13740 ENOG4105Z7P Acetyltransferase (GNAT) family BtBc_13745 ENOG4105ECQ AraC Family Transcriptional Regulator BtBc_13750 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BtBc_13755 ENOG4105KY5 gCN5-related N-acetyltransferase BtBc_13760 ENOG4107VMI polysaccharide deacetylase BtBc_13765 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BtBc_13770 ENOG4108TWJ NADH dehydrogenase subunit 5 BtBc_13785 ENOG4105F2M alpha beta hydrolase fold-3 domain protein BtBc_13810 ENOG4105CVP deoxyribo-dipyrimidine photolyase BtBc_13815 ENOG4108606 TspO/MBR family BtBc_13885 ENOG41090MY MarR family Transcriptional regulator BtBc_13910 ENOG4105CHJ isochorismatase hydrolase BtBc_13920 ENOG4105CGH 5'-nucleotidase BtBc_13935 ENOG41075H3 AraC family transcriptional regulator BtBc_13960 ENOG4105BZU Histidine kinase BtBc_13965 ENOG4105E2A Dehydrogenase BtBc_13990 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BtBc_14010 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BtBc_14025 ENOG4105IYK transposase BtBc_14030 ENOG4105DQ6 Transposase BtBc_14050 ENOG4105M18 -acetyltransferase BtBc_14060 ENOG4105DWD nucleoside recognition domain protein BtBc_14075 ENOG4105FDT acyl-CoA dehydrogenase BtBc_14085 ENOG4108ZHR arsR family transcriptional regulator BtBc_14090 ENOG4106N3A copper homeostasis protein cutc BtBc_14100 ENOG4107258 Transcriptional regulator BtBc_14105 ENOG4105P4J Allophanate hydrolase, subunit 1 BtBc_14135 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BtBc_14145 ENOG4107RF6 penicillin-binding protein BtBc_14185 ENOG4108IQI permease BtBc_14195 ENOG410635A Membrane BtBc_14230 ENOG4107XJU UPF0178 protein BtBc_14240 ENOG4108PCN EamA-like transporter family BtBc_14255 ENOG4108XET gCN5-related N-acetyltransferase BtBc_14260 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BtBc_14265 ENOG4108DMH HTH_ARAC BtBc_14285 ENOG4105WEC Molybdate metabolism regulator BtBc_14290 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BtBc_14305 ENOG4105FS7 Transcriptional regulator BtBc_14310 ENOG4108TVJ Nitroreductase BtBc_14330 ENOG4108IBT Inherit from COG: transposase BtBc_14395 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BtBc_14440 ENOG4105C8Y Acetylornithine aminotransferase BtBc_14465 ENOG4105CKK Glycosyl transferase, family 2 BtBc_14480 ENOG4105CKK Glycosyl transferase, family 2 BtBc_14505 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BtBc_14540 ENOG41068WN BtBc_14560 ENOG4105VMP Transcriptional regulator BtBc_14570 ENOG4105G6Z alkaline phosphatase BtBc_14575 ENOG4107RBI VanW family BtBc_14585 ENOG4105ECK Fatty Acid Desaturase BtBc_14600 ENOG4107258 Transcriptional regulator BtBc_14610 ENOG4105II7 pyrroline-5-carboxylate reductase BtBc_14625 ENOG4105DQ6 Transposase BtBc_14650 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BtBc_14665 ENOG41061GT Aldolase BtBc_14675 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BtBc_14680 ENOG4105DKT Transcriptional regulator BtBc_14690 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BtBc_14695 ENOG4105F5R ABC transporter BtBc_14700 ENOG4105D4B ABC, transporter BtBc_14715 ENOG4105DNP FAD linked oxidase domain protein BtBc_14725 ENOG41069ER domain protein BtBc_14765 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BtBc_14770 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BtBc_14795 ENOG41082JN Transcriptional regulator BtBc_14800 ENOG4105EYF MMPL domain protein BtBc_14815 ENOG4105C5H ABC transporter BtBc_14820 ENOG4105E0M Sulfatase BtBc_14825 ENOG4108ZCF integral membrane protein BtBc_14830 ENOG4107VMI polysaccharide deacetylase BtBc_14835 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BtBc_14840 ENOG4107VC0 DNA alkylation repair enzyme BtBc_14880 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BtBc_14905 ENOG4105D7T ABC transporter BtBc_14910 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BtBc_14915 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BtBc_14920 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BtBc_14930 ENOG4105C02 permease BtBc_14980 ENOG4105DVE abc transporter atp-binding protein BtBc_14995 ENOG4108ZMI UPF0477 protein BtBc_15010 ENOG4105CHM Aminotransferase BtBc_15045 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BtBc_15060 ENOG4107BMA Transglycosylase associated protein BtBc_15080 ENOG4106K7D Major facilitator family transporter BtBc_15085 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BtBc_15145 ENOG4105EPR degv family BtBc_15150 ENOG4105DPN Oligoendopeptidase f BtBc_15180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_15185 ENOG4105BZU Histidine kinase BtBc_15190 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BtBc_15195 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BtBc_15230 ENOG4107SET aldo keto reductase BtBc_15245 ENOG4105DTQ mandelate racemase muconate lactonizing BtBc_15265 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BtBc_15275 ENOG4107T5V SNARE associated Golgi BtBc_15305 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BtBc_15315 ENOG41080HI glycine oxidase BtBc_15320 ENOG4105CTU Proline racemase BtBc_15325 ENOG4105CTU Proline racemase BtBc_15330 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BtBc_15335 ENOG4105C26 Dehydrogenase BtBc_15340 ENOG4105BZG amino acid carrier protein BtBc_15350 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BtBc_15365 ENOG4108M1A Chitin-binding protein BtBc_15400 ENOG4105DQ6 Transposase BtBc_15420 ENOG4105DQ6 Transposase BtBc_15435 ENOG4105C9U ATP-dependent DNA helicase RecQ BtBc_15440 ENOG41066HZ AIG2-like family BtBc_15450 ENOG4105EEM helicase BtBc_15455 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BtBc_15475 ENOG4108Z7F N-acetyltransferase BtBc_15500 ENOG4105MSB protein, conserved in bacteria BtBc_15505 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BtBc_15530 ENOG41087PP glycosyltransferase MGT family BtBc_15535 ENOG4108M1A Chitin-binding protein BtBc_15540 ENOG41082BV acetyltransferase BtBc_15545 ENOG4105E66 phosphoriboisomerase A BtBc_15570 ENOG4108IJ7 Glycine betaine BtBc_15575 ENOG4107SQ8 Glycine betaine BtBc_15610 ENOG4105RHY Pfam:UPF0157 BtBc_15615 ENOG4105E1F short-chain dehydrogenase reductase BtBc_15630 ENOG4105EKQ RNA-directed DNA polymerase BtBc_15650 ENOG4105JHE Major Facilitator Superfamily BtBc_15660 ENOG4107RUY (E1 component), alpha subunit BtBc_15670 ENOG4107QKR Dehydrogenase BtBc_15685 ENOG41062ES Transcriptional regulator BtBc_15715 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BtBc_15745 ENOG4107Z3H Transcriptional regulator, TetR family BtBc_15750 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BtBc_15755 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BtBc_15785 ENOG4105MSI germination protein ypeb BtBc_15835 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BtBc_15840 ENOG4105FDR Membrane BtBc_15845 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BtBc_15860 ENOG4105CGH 5'-nucleotidase BtBc_15870 ENOG4108IUM Glycogen debranching enzyme BtBc_15915 ENOG4105DY8 decarboxylase BtBc_15930 ENOG4107WD8 ABC transporter, permease BtBc_15950 ENOG4105BZU Histidine kinase BtBc_15955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_15960 ENOG4105U0R haloacid dehalogenase-like hydrolase BtBc_15985 ENOG4107VFR oxidoreductase BtBc_16005 ENOG4105PKS Excinuclease abc c subunit domain protein BtBc_16015 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BtBc_16030 ENOG4108YYS metal-dependent hydrolase (By similarity) BtBc_16040 ENOG4105KWG Pfam:DUF1696 BtBc_16045 ENOG4108NRW Phospholipase, patatin family BtBc_16070 ENOG4108XI2 Domain of unknown function (DUF1963) BtBc_16095 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BtBc_16100 ENOG4105E09 nadh pyrophosphatase BtBc_16110 ENOG4105FCD Major Facilitator BtBc_16135 ENOG4105EGD dinuclear metal center protein, YbgI family BtBc_16155 ENOG4107Y9U Membrane BtBc_16175 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BtBc_16195 ENOG4107Y80 Major Facilitator superfamily BtBc_16200 ENOG4105F27 Major Facilitator BtBc_16245 ENOG4105CJN penicillin-binding protein BtBc_16250 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BtBc_16255 ENOG4105CB2 alcohol dehydrogenase BtBc_16260 ENOG4105GR3 Histidine kinase BtBc_16265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_16325 ENOG4108HGU Histidine kinase BtBc_16335 ENOG4108JJB ABC transporter BtBc_16360 ENOG4107RF6 penicillin-binding protein BtBc_16365 ENOG4105BZU Histidine kinase BtBc_16370 ENOG410667J hydrolase BtBc_16430 ENOG41085W3 Transposase BtBc_16465 ENOG4105ETU transcriptional activator (TenA BtBc_16470 ENOG4105CPF Cell wall formation (By similarity) BtBc_16480 ENOG4105D6E homoserine dehydrogenase BtBc_16525 ENOG4105EKQ RNA-directed DNA polymerase BtBc_16550 ENOG4105DK7 lysyl-tRNA synthetase BtBc_16555 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BtBc_16565 ENOG4108V4B ThiJ pfpI BtBc_16570 ENOG410900G Protein of unknown function (DUF421) BtBc_16590 ENOG4105EKQ RNA-directed DNA polymerase BtBc_16615 ENOG4105EFA 4-hydroxyphenylacetate BtBc_16650 ENOG4105CJ1 ABC, transporter BtBc_16660 ENOG4107V2S Transcriptional regulator BtBc_16665 ENOG4105MDS 4-oxalocrotonate tautomerase BtBc_16675 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BtBc_16720 ENOG41075H3 AraC family transcriptional regulator BtBc_16740 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BtBc_16750 ENOG4105T9C HD domain BtBc_16770 ENOG4105DZ1 carboxypeptidase BtBc_16780 ENOG4105DBI uridine monophosphokinase BtBc_16795 ENOG41085W3 Transposase BtBc_16820 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BtBc_16825 ENOG4107QX3 carboxylase BtBc_16830 ENOG4105E39 Enoyl-CoA hydratase BtBc_16835 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BtBc_16840 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BtBc_16845 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BtBc_16850 ENOG4105C1G acyl-Coa dehydrogenase BtBc_16865 ENOG4107Z3H Transcriptional regulator, TetR family BtBc_16875 ENOG4105CJ1 ABC, transporter BtBc_16900 ENOG4107RF6 penicillin-binding protein BtBc_16905 ENOG4107RF6 penicillin-binding protein BtBc_16920 ENOG4107RVG penicillin-binding protein BtBc_16930 ENOG4105CJW magnesium transporter BtBc_16935 ENOG4105CNI cell division protein FtsW BtBc_16945 ENOG4108NHD germination protein BtBc_16960 ENOG4105CVK Glutamate decarboxylase BtBc_16970 ENOG4105F6S Spore photoproduct lyase BtBc_16995 ENOG4105C44 Serine transporter BtBc_17000 ENOG4105EJQ L-serine dehydratase BtBc_17035 ENOG4105CAQ asparagine synthetase BtBc_17040 ENOG4108RZE Tetr family transcriptional regulator BtBc_17045 ENOG4107VMI polysaccharide deacetylase BtBc_17060 ENOG4108IMY Transcriptional regulator BtBc_17185 ENOG4108VXD carboxy-peptidase BtBc_17190 ENOG4105PNM synthesis protein BtBc_17200 ENOG4108ISG Major Facilitator BtBc_17215 ENOG4107MII Sugar-specific transcriptional regulator TrmB BtBc_17220 ENOG4105CZM Major Facilitator BtBc_17235 ENOG4105CRW Short chain fatty acid transporter BtBc_17245 ENOG4105DYS nad(p)h dehydrogenase (quinone) BtBc_17315 ENOG4108Z66 YbaK ebsC protein BtBc_17325 ENOG4105KVH Transcriptional regulator BtBc_17330 ENOG4108RCM Nitroreductase BtBc_17360 ENOG4108PSK reductase BtBc_17430 ENOG4105C31 Tryptophanyl-tRNA synthetase BtBc_17435 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BtBc_17465 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BtBc_17475 ENOG4105EV4 Multidrug resistance protein mdtH BtBc_17505 ENOG4105C37 (CBS) domain BtBc_17520 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BtBc_17525 ENOG4105FAW cDP-glucose 4,6-dehydratase BtBc_17560 ENOG4105DDN Pentapeptide repeat-containing protein BtBc_17565 ENOG4105XDF Protein of unknown function (DUF1272) BtBc_17570 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BtBc_17575 ENOG4105CMG Carbohydrate kinase BtBc_17580 ENOG4105C6Z Gluconate BtBc_17585 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BtBc_17595 ENOG4105CV1 Transketolase (EC 2.2.1.1) BtBc_17600 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BtBc_17625 ENOG4105C8Q Methyl-accepting chemotaxis BtBc_17630 ENOG4108UX3 '-nucleotidase BtBc_17635 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BtBc_17640 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BtBc_17645 ENOG4105KVH Transcriptional regulator BtBc_17660 ENOG4105C44 Serine transporter BtBc_17685 ENOG4108TZY GntR Family Transcriptional Regulator BtBc_17690 ENOG4105D9R oxidoreductase BtBc_17730 ENOG4105JAB phenazine biosynthesis protein, phzf family BtBc_17745 ENOG4105KNA -acetyltransferase BtBc_17755 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BtBc_17760 ENOG4105KVH Transcriptional regulator BtBc_17770 ENOG4108ZJ4 polysaccharide deacetylase BtBc_17835 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BtBc_17920 ENOG4108TN2 lmbE family BtBc_17930 ENOG4107R3E Citrate transporter BtBc_17940 ENOG4105WCN acetyltransferase BtBc_17945 ENOG4108MES Periplasmic binding protein BtBc_17950 ENOG4105EHG Permease protein BtBc_17955 ENOG4105DQ5 transport system permease protein BtBc_17960 ENOG4105NX3 Membrane BtBc_17980 ENOG41068WN BtBc_17985 ENOG4107CUJ Protein of unknown function (DUF2690) BtBc_17995 ENOG4107V2S Transcriptional regulator BtBc_18005 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BtBc_18020 ENOG4105C98 muts2 protein BtBc_18025 ENOG4105E5K Alpha-amylase BtBc_18030 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BtBc_18035 ENOG4105DPN Oligoendopeptidase f BtBc_18065 ENOG4108A04 Beta-lactamase BtBc_18090 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BtBc_18100 ENOG41082BM Transcriptional regulator, arsr family BtBc_18105 ENOG4105CIS alcohol dehydrogenase BtBc_18125 ENOG4105C09 Bile acid BtBc_18130 ENOG4105CQB FAD linked oxidase domain protein BtBc_18155 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BtBc_18165 ENOG4107TPS domain protein BtBc_18170 ENOG4105CEP NADH dehydrogenase BtBc_18180 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BtBc_18185 ENOG4108M1A Chitin-binding protein BtBc_18195 ENOG4105E1K spore germination protein BtBc_18225 ENOG4105EKQ RNA-directed DNA polymerase BtBc_18250 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BtBc_18260 ENOG4108IAJ Nad-dependent epimerase dehydratase BtBc_18265 ENOG4105FAW cDP-glucose 4,6-dehydratase BtBc_18345 ENOG4105C5H ABC transporter BtBc_18365 ENOG4105BZU Histidine kinase BtBc_18375 ENOG4105KT7 mgtC SapB transporter BtBc_18385 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BtBc_18390 ENOG41073R8 VanW family BtBc_18400 ENOG4108R1P BtBc_18415 ENOG4105VEQ Cold shock protein BtBc_18440 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BtBc_18460 ENOG410904N short-chain dehydrogenase reductase BtBc_18470 ENOG4106IQC argininosuccinate lyase BtBc_18485 ENOG4108IA2 Sodium pantothenate symporter BtBc_18495 ENOG4105C26 Dehydrogenase BtBc_18500 ENOG4105CHR reductase BtBc_18510 ENOG4105EWU Squalene--hopene cyclase BtBc_18520 ENOG4105FR1 rard protein BtBc_18525 ENOG410696E Membrane BtBc_18540 ENOG4105D1F ATP-binding protein BtBc_18550 ENOG4108ZAF Molybdopterin BtBc_18555 ENOG4105CVM Molybdenum cofactor synthesis domain protein BtBc_18560 ENOG4105D06 uba thif-type nad fad binding protein BtBc_18565 ENOG4105TMB Formate nitrite transporter BtBc_18575 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BtBc_18580 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BtBc_18590 ENOG4108JB9 formate dehydrogenase BtBc_18595 ENOG4105E1K spore germination protein BtBc_18610 ENOG4105CUB amino acid BtBc_18665 ENOG4108KGH TRANSCRIPTIONal BtBc_18675 ENOG4105EMN RNA polymerase sigma factor BtBc_18685 ENOG4105CIG ABC transporter BtBc_18705 ENOG4105D9R oxidoreductase BtBc_18715 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BtBc_18720 ENOG4105K4P CoA-binding domain protein BtBc_18725 ENOG4105C0H protease BtBc_18730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_18740 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BtBc_18745 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BtBc_18750 ENOG4105W8X HesB YadR YfhF-family protein BtBc_18760 ENOG4105D7V transposase BtBc_18785 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BtBc_18790 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BtBc_18800 ENOG4105BZ1 (ABC) transporter BtBc_18805 ENOG4108I0Z Aconitate hydratase BtBc_18835 ENOG4105E5W Transporter BtBc_18845 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BtBc_18865 ENOG4107F3J Amp-dependent synthetase and ligase BtBc_18870 ENOG4107ZYJ bioY protein BtBc_18875 ENOG4105CEY Amp-dependent synthetase and ligase BtBc_18880 ENOG4108IMY Transcriptional regulator BtBc_18905 ENOG4105D9G High-affinity BtBc_18910 ENOG4105IW1 AmiS UreI transporter BtBc_18925 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BtBc_18965 ENOG4107AYK membrAne BtBc_18975 ENOG4105BZU Histidine kinase BtBc_18980 ENOG4105FBA Phospholipase Carboxylesterase BtBc_18985 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BtBc_19000 ENOG4105CBC glutamate synthase BtBc_19010 ENOG4105EKQ RNA-directed DNA polymerase BtBc_19020 ENOG4108VJ1 Transcriptional regulator (CarD family BtBc_19025 ENOG4108903 Formimidoylglutamase BtBc_19035 ENOG4105CGP Urocanate hydratase BtBc_19050 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BtBc_19080 ENOG4107QIV Cytochrome c biogenesis protein BtBc_19090 ENOG4105CH2 amidohydrolase BtBc_19095 ENOG4105IYK transposase BtBc_19100 ENOG4105DQ6 Transposase BtBc_19125 ENOG4107RSM transcriptional regulator BtBc_19130 ENOG4105VAW lrga family BtBc_19135 ENOG41067MG lrgb family BtBc_19175 ENOG4105BZ1 (ABC) transporter BtBc_19180 ENOG4105BZ1 (ABC) transporter BtBc_19215 ENOG4108HW3 (ABC) transporter BtBc_19220 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BtBc_19240 ENOG4108SVB resolvase BtBc_19260 ENOG4105K7K Transcriptional regulator BtBc_19265 ENOG4105C5F glutamine synthetase BtBc_19270 ENOG4105KV4 Transcriptional regulator BtBc_19275 ENOG4105CXI aluminum resistance protein BtBc_19280 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BtBc_19285 ENOG4105EN6 Membrane BtBc_19295 ENOG4106F1P AAA ATPase, central domain protein BtBc_19325 ENOG41069ER domain protein BtBc_19330 ENOG4105DM4 PTS System BtBc_19335 ENOG4105DE4 1-phosphofructokinase BtBc_19340 ENOG4105E98 transcriptional regulator DeoR family BtBc_19345 ENOG4107QW4 alcohol dehydrogenase BtBc_19350 ENOG4108SJC Membrane BtBc_19365 ENOG4105C85 amino acid BtBc_19380 ENOG4105TMB Formate nitrite transporter BtBc_19385 ENOG4105K70 DNA-binding protein BtBc_19395 ENOG4105C59 p-type ATPase BtBc_19400 ENOG410681U heavy metal transport detoxification protein BtBc_19405 ENOG4105VPX protein, conserved in bacteria BtBc_19415 ENOG4105NIV Esterase BtBc_19420 ENOG4105E0A ABC, transporter BtBc_19445 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BtBc_19450 ENOG4105D03 DNA-3-methyladenine glycosylase II BtBc_19475 ENOG4105BZU Histidine kinase BtBc_19495 ENOG4105C5E polysaccharide biosynthesis protein BtBc_19510 ENOG41067MG lrgb family BtBc_19530 ENOG4108S3Y transcriptional regulator BtBc_19535 ENOG4105CS2 ec 3.2.1.21 BtBc_19540 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BtBc_19550 ENOG4105F0V Cell wall hydrolase BtBc_19560 ENOG4105E0M Sulfatase BtBc_19565 ENOG410890F Dynamin family BtBc_19600 ENOG4105DQU oxidoreductase, subunit beta BtBc_19605 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BtBc_19610 ENOG4108IGT Dipeptidase BtBc_19615 ENOG4105MCT stage V sporulation protein S BtBc_19620 ENOG4105D48 metallophosphoesterase BtBc_19640 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BtBc_19655 ENOG4105XZV Protein of unknown function (DUF3243) BtBc_19660 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BtBc_19680 ENOG4105UIB (ABC) transporter BtBc_19685 ENOG4108JQ9 ABC transporter BtBc_19690 ENOG4105DIH basic membrane BtBc_19695 ENOG4105FDP GntR family transcriptional regulator BtBc_19700 ENOG4105CNU cell division protein FtsK BtBc_19710 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BtBc_19720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BtBc_19730 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BtBc_19735 ENOG4108S0H Dipicolinic acid synthetase, b subunit BtBc_19740 ENOG4105E35 Dipicolinate synthase subunit A BtBc_19750 ENOG4105C1V Peptidase, M16 BtBc_19770 ENOG4105DTN riboflavin biosynthesis protein ribF BtBc_19785 ENOG4105W7A Protein of unknown function (DUF503) BtBc_19795 ENOG4105VHM ribosomal protein BtBc_19800 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BtBc_19805 ENOG4105CHV Transcription elongation factor NusA BtBc_19815 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BtBc_19825 ENOG4105DZP Membrane-associated zinc metalloprotease BtBc_19830 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BtBc_19835 ENOG4105KNE Phosphatidate cytidylyltransferase BtBc_19840 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BtBc_19850 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BtBc_19880 ENOG4108HE4 integrase family BtBc_19890 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BtBc_19895 ENOG4105C79 DNA protecting protein DprA BtBc_19900 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BtBc_19915 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BtBc_19940 ENOG4105VB6 UPF0109 protein BtBc_19960 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BtBc_19965 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BtBc_19970 ENOG4105EKQ RNA-directed DNA polymerase BtBc_19975 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BtBc_19990 ENOG4105CHR reductase BtBc_19995 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BtBc_20010 ENOG4105CB5 ATP-dependent DNA helicase recG BtBc_20015 ENOG4105DP4 dak2 domain fusion protein ylov BtBc_20020 ENOG4108ZAA Alkaline-shock protein BtBc_20035 ENOG4105FJ0 thiamine BtBc_20040 ENOG4105DJV ribulose-phosphate 3-epimerase BtBc_20045 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BtBc_20050 ENOG4105D9P serine threonine protein kinase BtBc_20055 ENOG4108ZF3 Phosphatase BtBc_20065 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BtBc_20080 ENOG4105C25 Primosomal protein n' BtBc_20085 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BtBc_20105 ENOG4105DSJ YicC domain protein BtBc_20115 ENOG4105F23 Fibronectin-binding protein BtBc_20120 ENOG4105DC7 peptidase M24 BtBc_20145 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BtBc_20160 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BtBc_20165 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BtBc_20175 ENOG4105CD3 dihydroorotase BtBc_20195 ENOG4105C34 Pseudouridine synthase BtBc_20210 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BtBc_20220 ENOG4105DBK s4 domain protein BtBc_20225 ENOG41067XK integral membrane protein BtBc_20235 ENOG4105DFA alanine racemase domain protein BtBc_20240 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BtBc_20245 ENOG4105WR5 sporulation protein, YlmC YmxH family BtBc_20255 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BtBc_20265 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BtBc_20270 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BtBc_20280 ENOG4105D4A Cell wall formation (By similarity) BtBc_20285 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BtBc_20290 ENOG4105CNI cell division protein FtsW BtBc_20305 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BtBc_20310 ENOG4105CJN penicillin-binding protein BtBc_20315 ENOG4105CJN penicillin-binding protein BtBc_20330 ENOG41074B2 UPF0747 protein BtBc_20355 ENOG4105KNH Nucleic acid-binding protein BtBc_20365 ENOG41063PX domain protein BtBc_20370 ENOG4105D78 K07001 NTE family protein BtBc_20375 ENOG4105H20 Sporulation integral membrane protein YlbJ BtBc_20385 ENOG4106H78 methyltransferase BtBc_20405 ENOG4107TB6 phosphoglycerate mutase BtBc_20420 ENOG4106UY4 Inherit from COG: Scp-like extracellular BtBc_20470 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BtBc_20475 ENOG4105CNI cell division protein FtsW BtBc_20490 ENOG4108IAB Phoh family BtBc_20510 ENOG4105QA2 BtBc_20515 ENOG4105CI3 gtp-binding protein typa BtBc_20525 ENOG4105ECY inositol monophosphatase BtBc_20545 ENOG4105CXN decarboxylase BtBc_20590 ENOG4105CPP Dehydrogenase, E1 component BtBc_20605 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BtBc_20610 ENOG4108X4Q Hydrolase BtBc_20620 ENOG4105CN5 Metallo-Beta-Lactamase BtBc_20625 ENOG4107ZYR domain protein BtBc_20660 ENOG4108XRC Protein of unknown function (DUF458) BtBc_20670 ENOG4107IN1 Protein of unknown function (DUF1797) BtBc_20685 ENOG4105EPM Diguanylate phosphodiesterase BtBc_20690 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BtBc_20705 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BtBc_20715 ENOG4105UIN BtBc_20750 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BtBc_20770 ENOG4108HGU Histidine kinase BtBc_20780 ENOG4105CHM Aminotransferase BtBc_20785 ENOG4105FKQ transcriptional regulator BtBc_20790 ENOG4105EG2 ABC transporter, permease BtBc_20800 ENOG4107FKK extracellular solute-binding protein family 1 BtBc_20810 ENOG4105CG3 alpha amylase, catalytic region BtBc_20850 ENOG4105CHU acetyl-coa acetyltransferase BtBc_20880 ENOG4105K7K Transcriptional regulator BtBc_20885 ENOG4105DTD Dehydrogenase BtBc_20905 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BtBc_20930 ENOG4105C26 Dehydrogenase BtBc_20935 ENOG41082BM Transcriptional regulator, arsr family BtBc_20965 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BtBc_20990 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BtBc_21005 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BtBc_21015 ENOG4105BZU Histidine kinase BtBc_21035 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BtBc_21050 ENOG4105CID antiterminator BtBc_21060 ENOG4105FDP GntR family transcriptional regulator BtBc_21070 ENOG4105CE4 GlcNAc 6-P deacetylase BtBc_21105 ENOG4107ZE5 PPIases accelerate the folding of proteins BtBc_21110 ENOG4105PTM secreted protein BtBc_21115 ENOG4105J7I hydrolase BtBc_21125 ENOG4105G6R Stage v sporulation protein ae BtBc_21135 ENOG4105CZ3 stage V sporulation protein ad BtBc_21140 ENOG41090VF Stage v sporulation protein ac BtBc_21165 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BtBc_21175 ENOG41082AN stage II sporulation protein BtBc_21180 ENOG4105DZ1 carboxypeptidase BtBc_21185 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BtBc_21190 ENOG4105DVE abc transporter atp-binding protein BtBc_21220 ENOG4105D7N magnesium and cobalt transport protein CorA BtBc_21245 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BtBc_21255 ENOG4105I3K Ferric uptake regulator, Fur family BtBc_21260 ENOG4105MZ9 stage II sporulation protein m BtBc_21280 ENOG4105CPC Aldo Keto reductase BtBc_21290 ENOG4105RHY Pfam:UPF0157 BtBc_21310 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BtBc_21320 ENOG4105ETE Transcriptional regulator (LacI family BtBc_21325 ENOG4108YM7 Gcn5-related n-acetyltransferase BtBc_21345 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BtBc_21350 ENOG4108R6K riboflavin synthase, subunit alpha BtBc_21375 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BtBc_21380 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BtBc_21395 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BtBc_21405 ENOG4105DFD Na H antiporter BtBc_21410 ENOG4105CGH 5'-nucleotidase BtBc_21435 ENOG4105DBV ornithine carbamoyltransferase BtBc_21450 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BtBc_21465 ENOG4108IXY short-chain dehydrogenase reductase BtBc_21470 ENOG41069FQ Metallo-beta-lactamase superfamily BtBc_21475 ENOG4105II7 pyrroline-5-carboxylate reductase BtBc_21480 ENOG4105EJQ L-serine dehydratase BtBc_21490 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BtBc_21510 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BtBc_21525 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BtBc_21530 ENOG4105D9U N-acetyltransferase BtBc_21540 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BtBc_21545 ENOG4108QEG Membrane BtBc_21550 ENOG4105CDA abc transporter atp-binding protein BtBc_21555 ENOG4105E5Q amino acid AbC transporter BtBc_21560 ENOG4108HW3 (ABC) transporter BtBc_21570 ENOG4105G7B Protein of unknown function (DUF2992) BtBc_21580 ENOG4108QY0 Membrane BtBc_21590 ENOG4105C7S Dehydrogenase BtBc_21595 ENOG4105CPP Dehydrogenase, E1 component BtBc_21615 ENOG4107RDP Dehydrogenase BtBc_21625 ENOG4108JUB Transcriptional regulator BtBc_21635 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BtBc_21650 ENOG4107QQR Sporulation BtBc_21655 ENOG4105S1Z Stage IV sporulation protein B BtBc_21660 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BtBc_21665 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BtBc_21670 ENOG4105DX0 Hemolysin A BtBc_21680 ENOG4105CTB Polyprenyl synthetase BtBc_21695 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BtBc_21705 ENOG4108ZSR alkaline shock protein BtBc_21710 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BtBc_21730 ENOG410644B Stage III sporulation protein af BtBc_21740 ENOG4105KQ4 Stage iii sporulation protein ad BtBc_21745 ENOG4108CQH stage III sporulation protein AC BtBc_21750 ENOG4105KR5 Stage iii sporulation protein BtBc_21755 ENOG4105CD2 stage iii sporulation protein aa BtBc_21780 ENOG4105DC7 peptidase M24 BtBc_21785 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BtBc_21795 ENOG4105CBJ Metal-dependent enzyme BtBc_21805 ENOG4107YBY Hydrolase BtBc_21835 ENOG41082GG biotin lipoate A B protein ligase BtBc_21840 ENOG4105WZW rhodanese family BtBc_21865 ENOG41080TC multidrug resistance protein BtBc_21895 ENOG4105CJ1 ABC, transporter BtBc_21900 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BtBc_21930 ENOG4105C0D helicase BtBc_22050 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BtBc_22055 ENOG4105C3R Methionine synthase BtBc_22065 ENOG4105C28 cystathionine BtBc_22070 ENOG4105C28 cystathionine BtBc_22090 ENOG4105C5X domain protein BtBc_22095 ENOG4105DKQ ROK family BtBc_22105 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BtBc_22120 ENOG4108UTW Plays a role in the regulation of phosphate uptake BtBc_22125 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BtBc_22130 ENOG4105C8U phosphate abc transporter BtBc_22135 ENOG4105C8U phosphate abc transporter BtBc_22140 ENOG4105EXS phosphate abc transporter BtBc_22145 ENOG4107RF6 penicillin-binding protein BtBc_22155 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BtBc_22180 ENOG4105N80 Ferric uptake regulator, Fur family BtBc_22190 ENOG4105FDK ABC transporter BtBc_22195 ENOG4108JYZ YitT family BtBc_22200 ENOG41069ZM Protein of unknown function (DUF2624) BtBc_22225 ENOG4105EGD dinuclear metal center protein, YbgI family BtBc_22240 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BtBc_22245 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BtBc_22270 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BtBc_22275 ENOG4105KG3 cytidine deaminase BtBc_22280 ENOG4107YR5 Diacylglycerol kinase BtBc_22290 ENOG4105CTJ Metal Dependent Phosphohydrolase BtBc_22295 ENOG4105C9A Phoh family BtBc_22305 ENOG41068P3 sporulation protein YqfC BtBc_22310 ENOG4105KTH gatB Yqey BtBc_22320 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BtBc_22325 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BtBc_22355 ENOG4105CSA Coproporphyrinogen iii oxidase BtBc_22360 ENOG4105KVH Transcriptional regulator BtBc_22385 ENOG4105TQK DNA polymerase iii, delta' subunit BtBc_22395 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BtBc_22400 ENOG4108UK2 deaminase BtBc_22405 ENOG4105KQC Competence protein BtBc_22415 ENOG4105DXX methyltransferase BtBc_22425 ENOG4108WF2 Metal Dependent Phosphohydrolase BtBc_22435 ENOG410812S Rna-binding protein BtBc_22445 ENOG4105CQW ribosome biogenesis GTPase YqeH BtBc_22450 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BtBc_22465 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BtBc_22485 ENOG4108TVJ Nitroreductase BtBc_22500 ENOG4105G6Z alkaline phosphatase BtBc_22505 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BtBc_22510 ENOG4108MUZ hydrolase BtBc_22560 ENOG4105MIR Phenylalanine 4-monooxygenase BtBc_22570 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BtBc_22610 ENOG4105S6R Iron-hydroxamate transporter permease subunit BtBc_22615 ENOG4108V5C ABC transporter BtBc_22625 ENOG4108EKI Dehydrogenase BtBc_22630 ENOG4105C28 cystathionine BtBc_22660 ENOG4107XRG penicillin-binding protein BtBc_22670 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BtBc_22680 ENOG4105CFP Peptidase U32 BtBc_22685 ENOG4105XYU peptidase (U32 family) BtBc_22690 ENOG4108VQJ O-methyltransferase BtBc_22695 ENOG4105HHA aminodeoxychorismate lyase BtBc_22715 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BtBc_22725 ENOG4105C02 permease BtBc_22740 ENOG41060CR BtBc_22745 ENOG4105C7H Helicase, RecD TraA family BtBc_22755 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BtBc_22760 ENOG4105C3J Cysteine desulfurase BtBc_22770 ENOG4105D1H recombination factor protein RarA BtBc_22775 ENOG4108VCI transcription factor, rsfa family BtBc_22785 ENOG4105CUZ uba thif-type nad fad binding protein BtBc_22795 ENOG4105CUT histidyl-tRNA synthetase BtBc_22805 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BtBc_22810 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BtBc_22820 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BtBc_22825 ENOG41076HS cation diffusion facilitator family transporter BtBc_22830 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BtBc_22840 ENOG4105CKP Polysaccharide Biosynthesis Protein BtBc_22845 ENOG4108QG2 Membrane BtBc_22855 ENOG4105VIE preprotein translocase, subunit YajC BtBc_22870 ENOG41061AI Protein of unknown function (DUF2905) BtBc_22885 ENOG4108HUF Transporter BtBc_22910 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BtBc_22915 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BtBc_22920 ENOG4108IYU L-aspartate oxidase BtBc_22935 ENOG4108RPX mosc domain containing protein BtBc_22940 ENOG4105CQC Prephenate dehydratase BtBc_22955 ENOG4105C19 ABC transporter BtBc_22960 ENOG4105EWM Histidine kinase BtBc_22970 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BtBc_22985 ENOG4105X36 (ribosomal) protein BtBc_22995 ENOG4105C03 ribonuclease BtBc_23010 ENOG4107QMS site-determining protein BtBc_23025 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BtBc_23030 ENOG4105DFF Rod shape-determining protein mreb BtBc_23050 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BtBc_23055 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BtBc_23065 ENOG41068KH stage VI sporulation protein D BtBc_23075 ENOG4105D52 delta-aminolevulinic acid dehydratase BtBc_23100 ENOG4105K56 Transcriptional regulator BtBc_23120 ENOG4108IUQ atp-dependent protease BtBc_23140 ENOG4108QCI YvbH-like oligomerisation region BtBc_23160 ENOG4105M59 Phosphodiesterase, mj0936 family BtBc_23165 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BtBc_23175 ENOG4108XJQ germination protein BtBc_23195 ENOG4105PFC Transcriptional regulator BtBc_23205 ENOG4105DZC cytosine deaminase BtBc_23210 ENOG41067S9 phage shock protein C, PspC BtBc_23215 ENOG4108JCI Transcriptional regulator BtBc_23225 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BtBc_23230 ENOG4108Z40 Transcriptional regulator BtBc_23235 ENOG4105RHA ABC transporter, permease BtBc_23240 ENOG4108IUX (ABC) transporter BtBc_23245 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BtBc_23250 ENOG4105ER2 Ompa motb domain protein BtBc_23255 ENOG4105E14 MotA TolQ exbB proton channel BtBc_23260 ENOG4108VXD carboxy-peptidase BtBc_23270 ENOG4105E33 succinate dehydrogenase BtBc_23280 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BtBc_23290 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BtBc_23295 ENOG4105K63 Thioredoxin BtBc_23300 ENOG4105C10 Electron transfer flavoprotein BtBc_23305 ENOG4105BZJ Electron transfer flavoprotein BtBc_23310 ENOG41060WC Enoyl-CoA hydratase BtBc_23315 ENOG4107Z3H Transcriptional regulator, TetR family BtBc_23320 ENOG4105CEY Amp-dependent synthetase and ligase BtBc_23330 ENOG4105J76 Periplasmic binding protein BtBc_23380 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BtBc_23395 ENOG4105DR4 Methyltransferase BtBc_23405 ENOG4105KFN sortase, SrtB family BtBc_23410 ENOG4105E0A ABC, transporter BtBc_23425 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BtBc_23435 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BtBc_23445 ENOG4105FE9 pseudouridine synthase BtBc_23455 ENOG4105DCG PHP domain protein BtBc_23470 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BtBc_23490 ENOG4105C5S asparaginyl-tRNA synthetase BtBc_23495 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BtBc_23505 ENOG4108RWN rrna methyltransferase BtBc_23535 ENOG4105C0R drug resistance transporter emrb qaca subfamily BtBc_23540 ENOG4105CW7 secretion protein, HlyD family BtBc_23545 ENOG4108JGH Tetr family transcriptional regulator BtBc_23550 ENOG4105CN9 Peptidase m42 family protein BtBc_23570 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BtBc_23575 ENOG4105C22 threonyL-tRNA synthetase BtBc_23580 ENOG4108TDW sporulation protein YtxC BtBc_23605 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BtBc_23610 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BtBc_23615 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BtBc_23625 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BtBc_23630 ENOG4105C2M dna polymerase I BtBc_23635 ENOG4105BZU Histidine kinase BtBc_23640 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BtBc_23660 ENOG4108HMX isocitrate dehydrogenase (NADP) BtBc_23665 ENOG4105BZN citrate synthase BtBc_23675 ENOG4108REF Sporulation integral membrane protein ytvi BtBc_23680 ENOG4105FS0 cytoplasmic membrane protein BtBc_23705 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BtBc_23710 ENOG4105C6K Malic enzyme BtBc_23715 ENOG4105C0B DNA polymerase III (alpha subunit) BtBc_23720 ENOG4105VV2 BtBc_23730 ENOG4105SFS phosphoesterase RecJ domain protein BtBc_23755 ENOG4105E8R UPF0173 metal-dependent hydrolase BtBc_23760 ENOG4105DC7 peptidase M24 BtBc_23795 ENOG41082W1 Cupin 2, conserved barrel domain protein BtBc_23815 ENOG4107YZX Universal stress protein BtBc_23860 ENOG4108JYZ YitT family BtBc_23880 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BtBc_23890 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BtBc_23895 ENOG4105KBJ sporulation protein ytfj BtBc_23910 ENOG4105EFZ amidohydrolase BtBc_23920 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BtBc_23945 ENOG4105RQF LysR family Transcriptional regulator BtBc_23955 ENOG4105U5Y Transcriptional regulator BtBc_23965 ENOG4105C28 cystathionine BtBc_24005 ENOG4105EMN RNA polymerase sigma factor BtBc_24015 ENOG4108UW5 maltose o-acetyltransferase BtBc_24025 ENOG4105F1V Acetoin utilization protein BtBc_24030 ENOG4105W87 Cbs domain BtBc_24035 ENOG4105DGU Histone deacetylase BtBc_24050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BtBc_24060 ENOG4107SNB ankyrin repeat protein YahD BtBc_24085 ENOG4105DY9 regulatoR BtBc_24090 ENOG4105EP9 oxidoreductase BtBc_24120 ENOG4105ETE Transcriptional regulator (LacI family BtBc_24125 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BtBc_24145 ENOG4105C88 aminopeptidase BtBc_24190 ENOG4108VDD TRNA binding domain protein BtBc_24220 ENOG4105C8F Beta-lactamase domain protein BtBc_24235 ENOG4108V15 phosphotransferase enzyme family BtBc_24240 ENOG4108IUM Glycogen debranching enzyme BtBc_24250 ENOG4107QSE Dipeptidase BtBc_24255 ENOG4105YW5 deoR family transcriptional regulator BtBc_24270 ENOG4105CBX hi0933 family BtBc_24305 ENOG4108VJ1 Transcriptional regulator (CarD family BtBc_24310 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BtBc_24315 ENOG4105CSC Glucose uptake protein BtBc_24330 ENOG4108ZAF Molybdopterin BtBc_24335 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BtBc_24340 ENOG4105CVM Molybdenum cofactor synthesis domain protein BtBc_24350 ENOG4105D06 uba thif-type nad fad binding protein BtBc_24355 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BtBc_24375 ENOG41085GJ domain protein BtBc_24385 ENOG4105DWV Homoserine O-trans-acetylase BtBc_24395 ENOG4108B31 Spore germination protein BtBc_24425 ENOG4105C8T Leucyl-tRNA synthetase BtBc_24430 ENOG410605W Major Facilitator BtBc_24435 ENOG4107S91 Sodium hydrogen exchanger BtBc_24440 ENOG4105NCW Trka-c domain protein BtBc_24455 ENOG4105C19 ABC transporter BtBc_24475 ENOG4105N5T Radical SAM Protein BtBc_24505 ENOG4105E8V Alpha Beta Hydrolase Fold protein BtBc_24510 ENOG4108Z0R Transferase BtBc_24515 ENOG4105YVM Phosphoesterase, PA-phosphatase related BtBc_24520 ENOG4105BZF Glycosyl transferase (Group 1 BtBc_24530 ENOG4105EPU Molybdenum cofactor synthesis domain protein BtBc_24545 ENOG4108MK9 spermidine N(1)-acetyltransferase BtBc_24585 ENOG4107XGZ Hydrolase BtBc_24590 ENOG4105E98 transcriptional regulator DeoR family BtBc_24600 ENOG4105BZU Histidine kinase BtBc_24605 ENOG4105BZU Histidine kinase BtBc_24610 ENOG4107S9D Alpha beta hydrolase BtBc_24615 ENOG4107T7U Sulfatase BtBc_24635 ENOG4105D2X ABC transporter substrate-binding protein BtBc_24645 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BtBc_24705 ENOG4108V2W Carbonate dehydratase BtBc_24710 ENOG4105C4M (Ubiquinol oxidase) subunit I BtBc_24715 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BtBc_24750 ENOG41087YS Phage shock protein A BtBc_24780 ENOG4105BZU Histidine kinase BtBc_24785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_24810 ENOG4108UGV hypoxanthine phosphoribosyltransferase BtBc_24815 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BtBc_24840 ENOG4107ZTW SNARE associated Golgi BtBc_24855 ENOG4105C19 ABC transporter BtBc_24860 ENOG41086D8 Transcriptional regulator BtBc_24875 ENOG41082BM Transcriptional regulator, arsr family BtBc_24925 ENOG4105C6Z Gluconate BtBc_24935 ENOG4105DQ6 Transposase BtBc_24940 ENOG4105FDP GntR family transcriptional regulator BtBc_24960 ENOG41069H0 dihydroorotase EC 3.5.2.3 BtBc_24980 ENOG4105DTQ mandelate racemase muconate lactonizing BtBc_25000 ENOG4108IPT Naphthoate synthase BtBc_25005 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BtBc_25015 ENOG4105E4F Isochorismate synthase BtBc_25020 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BtBc_25030 ENOG4105VEQ Cold shock protein BtBc_25070 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BtBc_25090 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BtBc_25185 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BtBc_25220 ENOG4105KT7 mgtC SapB transporter BtBc_25225 ENOG4107PBV potassium channel BtBc_25240 ENOG4105WG9 Conserved Protein BtBc_25250 ENOG4105CHM Aminotransferase BtBc_25255 ENOG4108ZB6 transcriptional regulator AsnC family BtBc_25260 ENOG4105C5I Dehydrogenase BtBc_25265 ENOG4108MUZ hydrolase BtBc_25275 ENOG4105C87 Aminotransferase class I and II BtBc_25290 ENOG4105Y38 Kinase-associated protein B BtBc_25300 ENOG4107R3E Citrate transporter BtBc_25315 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BtBc_25325 ENOG4105DQ6 Transposase BtBc_25330 ENOG4105KA0 thioesterase Superfamily protein BtBc_25345 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BtBc_25365 ENOG41069ER domain protein BtBc_25380 ENOG4105CEP NADH dehydrogenase BtBc_25410 ENOG4105EWC Purine nucleoside phosphorylase BtBc_25470 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BtBc_25475 ENOG4105XSJ toxin secretion phage lysis holin BtBc_25535 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BtBc_25545 ENOG4105CAR Terminase, large subunit BtBc_25660 ENOG4108IMY Transcriptional regulator BtBc_25695 ENOG4105IYK transposase BtBc_25700 ENOG4105DQ6 Transposase BtBc_25705 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BtBc_25730 ENOG4108JJA ABC, transporter BtBc_25735 ENOG4105C4B ABC transporter, permease BtBc_25740 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BtBc_25790 ENOG41083MR nifu domain-containing protein BtBc_25805 ENOG4108W5N phosphatidylglycerophosphatase a BtBc_25825 ENOG4105DAX Pfam:DUF2983 BtBc_25835 ENOG4105DYS nad(p)h dehydrogenase (quinone) BtBc_25840 ENOG4105D4U had-superfamily hydrolase, subfamily iia BtBc_25855 ENOG4105CBT Fructose-1,6-bisphosphatase BtBc_25875 ENOG4105MMD transcriptional regulator BtBc_25880 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BtBc_25885 ENOG4107TXC Transcriptional regulator BtBc_25890 ENOG41090T1 Membrane BtBc_25915 ENOG4105FAA peptidase M23 BtBc_25920 ENOG4108YTE sporulation protein YunB BtBc_25925 ENOG4105KZD Domain of unknown function (DUF1805) BtBc_25930 ENOG4107R8B 5'-nucleotidase BtBc_25935 ENOG4105DIW FeS assembly protein SUFB BtBc_25940 ENOG4108UNV SUF system FeS assembly protein, NifU family BtBc_25945 ENOG4105C9B Cysteine desulfurase BtBc_25950 ENOG4105JRK feS assembly protein SufD BtBc_25955 ENOG4105C3K feS assembly ATPase SufC BtBc_25960 ENOG4105D01 (LipO)protein BtBc_25965 ENOG4105D01 (LipO)protein BtBc_25970 ENOG4108UMI ABC transporter, permease BtBc_25975 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BtBc_26000 ENOG41080E8 Transcriptional regulator, Spx MgsR family BtBc_26020 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BtBc_26040 ENOG4108W8B Beta-lactamase domain protein BtBc_26045 ENOG4105C1G acyl-Coa dehydrogenase BtBc_26050 ENOG4105CHU acetyl-coa acetyltransferase BtBc_26065 ENOG4105DZ1 carboxypeptidase BtBc_26085 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BtBc_26100 ENOG4108SUT Major Facilitator Superfamily BtBc_26105 ENOG4107R7I amino acid BtBc_26115 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BtBc_26125 ENOG4107AYK membrAne BtBc_26155 ENOG4107ZTW SNARE associated Golgi BtBc_26165 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BtBc_26170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_26175 ENOG4105BZU Histidine kinase BtBc_26190 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BtBc_26205 ENOG4105C8Q Methyl-accepting chemotaxis BtBc_26210 ENOG4105VG1 fes assembly suf system protein BtBc_26215 ENOG4105D4Y metalloprotease BtBc_26220 ENOG4105C2I pirin domain protein BtBc_26235 ENOG4107T5V SNARE associated Golgi BtBc_26240 ENOG4107S91 Sodium hydrogen exchanger BtBc_26245 ENOG4105NCW Trka-c domain protein BtBc_26255 ENOG4108RMU ferritin dps family protein BtBc_26270 ENOG4108URH decarboxylase BtBc_26280 ENOG41090A1 ferritin BtBc_26290 ENOG4105D9N nucleoside BtBc_26295 ENOG4105D9N nucleoside BtBc_26300 ENOG4105EKQ RNA-directed DNA polymerase BtBc_26310 ENOG4105D9N nucleoside BtBc_26325 ENOG4108RYK Nad-dependent epimerase dehydratase BtBc_26340 ENOG4105CV8 reductase BtBc_26345 ENOG4105F27 Major Facilitator BtBc_26350 ENOG4105KVH Transcriptional regulator BtBc_26365 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BtBc_26370 ENOG4105D4A Cell wall formation (By similarity) BtBc_26390 ENOG4105WMR Protein CrcB homolog BtBc_26395 ENOG4105WMR Protein CrcB homolog BtBc_26415 ENOG4105C5H ABC transporter BtBc_26420 ENOG4108MK9 spermidine N(1)-acetyltransferase BtBc_26425 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BtBc_26450 ENOG4108IPW abc transporter atp-binding protein BtBc_26455 ENOG4105CM4 permease protein BtBc_26470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_26485 ENOG4105EKQ RNA-directed DNA polymerase BtBc_26515 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BtBc_26525 ENOG4105XZU Preprotein translocase, subunit SecG BtBc_26530 ENOG41067MG lrgb family BtBc_26580 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BtBc_26615 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BtBc_26620 ENOG41085W3 Transposase BtBc_26625 ENOG4105XSJ toxin secretion phage lysis holin BtBc_26630 ENOG41085W3 Transposase BtBc_26695 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BtBc_26765 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BtBc_26845 ENOG4106050 phage regulatory protein, rha family BtBc_26870 ENOG4105VTR Integrase BtBc_26890 ENOG41090VF Stage v sporulation protein ac BtBc_26895 ENOG4105CZ3 stage V sporulation protein ad BtBc_26910 ENOG4108QY0 Membrane BtBc_26915 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BtBc_26920 ENOG4105KRI phosphocarrier protein (HPr BtBc_26930 ENOG4105CHW UPF0052 protein BtBc_26935 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BtBc_26940 ENOG4108Z4K mutator MutT protein BtBc_26950 ENOG4105C3M thioredoxin reductase BtBc_26960 ENOG4108S4C acetyltransferase BtBc_26980 ENOG41086DT Membrane protein of unknown function BtBc_26990 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BtBc_26995 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BtBc_27010 ENOG4107TXC Transcriptional regulator BtBc_27030 ENOG4105DUM transcriptional regulator, lysR family BtBc_27040 ENOG4108WS4 fmn reductase BtBc_27055 ENOG4105BZ1 (ABC) transporter BtBc_27065 ENOG4105CN1 protease BtBc_27070 ENOG4105CRP Part of the ABC transporter FtsEX involved in BtBc_27075 ENOG4105CAK Cell division ATP-binding protein ftsE BtBc_27085 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BtBc_27100 ENOG4108RDQ ABC transporter BtBc_27130 ENOG4105MS2 ribosomal subunit Interface protein BtBc_27135 ENOG4105VEQ Cold shock protein BtBc_27140 ENOG41081UC Inherit from COG: Competence protein BtBc_27155 ENOG4105KVH Transcriptional regulator BtBc_27165 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BtBc_27170 ENOG4108KGH TRANSCRIPTIONal BtBc_27175 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BtBc_27180 ENOG4105C6Y Udp-glucose 6-dehydrogenase BtBc_27185 ENOG4105ESV Glycosyl transferase, family 4 BtBc_27195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BtBc_27215 ENOG4105F8D glycoside hydrolase family 4 BtBc_27220 ENOG4105VCP PTS System BtBc_27225 ENOG4105CK1 PTS System BtBc_27235 ENOG4105VCP PTS System BtBc_27245 ENOG4105VZJ PTS System BtBc_27265 ENOG4105ECB domain protein BtBc_27270 ENOG4107RSM transcriptional regulator BtBc_27305 ENOG4105DAA L-lactate BtBc_27310 ENOG4105D7V transposase BtBc_27320 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BtBc_27330 ENOG4105E0M Sulfatase BtBc_27355 ENOG4107R8N Glycosyl transferase, family 2 BtBc_27365 ENOG4105C94 Transporter BtBc_27370 ENOG41069ER domain protein BtBc_27395 ENOG4105KBK Zinc finger, swim domain protein BtBc_27400 ENOG4105C0D helicase BtBc_27430 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BtBc_27440 ENOG4107RBB ABC transporter, permease BtBc_27445 ENOG4105C19 ABC transporter BtBc_27455 ENOG4105CXY transporter BtBc_27470 ENOG4105BZU Histidine kinase BtBc_27475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_27485 ENOG4108KGH TRANSCRIPTIONal BtBc_27490 ENOG4105CMR udp-glucose 4-epimerase BtBc_27495 ENOG4105C6Y Udp-glucose 6-dehydrogenase BtBc_27510 ENOG4107STW synthase BtBc_27520 ENOG4105K64 Glycosyl transferase, family 2 BtBc_27530 ENOG4105D3Q Sugar transferase BtBc_27535 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BtBc_27540 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BtBc_27545 ENOG4107YJ4 chain length determinant protein BtBc_27550 ENOG4105HTX biosynthesis protein BtBc_27555 ENOG4107YJ4 chain length determinant protein BtBc_27570 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BtBc_27580 ENOG4105FRN stage II sporulation protein BtBc_27595 ENOG4105DY9 regulatoR BtBc_27615 ENOG4106778 Protein of unknown function (DUF1146) BtBc_27620 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BtBc_27625 ENOG4105C8S subunit m BtBc_27630 ENOG4105D65 subunit l BtBc_27655 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BtBc_27660 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BtBc_27670 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BtBc_27725 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BtBc_27730 ENOG41062M3 atp synthase BtBc_27750 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BtBc_27755 ENOG4108UIC UPF0340 protein BtBc_27760 ENOG4108YZG isomerase BtBc_27775 ENOG4108VGI doxx family BtBc_27780 ENOG4107XC4 flavin reductase domain protein, FMN-binding BtBc_27800 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BtBc_27810 ENOG4108ZXQ stage ii sporulation protein r BtBc_27815 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BtBc_27820 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BtBc_27825 ENOG4107104 thymidine kinase BtBc_27835 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BtBc_27840 ENOG4105CBT Fructose-1,6-bisphosphatase BtBc_27845 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BtBc_27865 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BtBc_27880 ENOG4105C1G acyl-Coa dehydrogenase BtBc_27885 ENOG4105C1G acyl-Coa dehydrogenase BtBc_27890 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BtBc_27900 ENOG4105DF6 Fe-S oxidoreductase BtBc_27920 ENOG4105EKQ RNA-directed DNA polymerase BtBc_27940 ENOG4105BZU Histidine kinase BtBc_27955 ENOG4105D4Y metalloprotease BtBc_27965 ENOG4105BZU Histidine kinase BtBc_27970 ENOG4105KCT ABC transporter BtBc_27975 ENOG4108M15 ABC transporter BtBc_27980 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BtBc_27990 ENOG4105IIU Aminopeptidase BtBc_27995 ENOG4105DQ6 Transposase BtBc_28020 ENOG4105EMN RNA polymerase sigma factor BtBc_28030 ENOG410684U Domain of unknown function (DUF1934) BtBc_28050 ENOG4105CYW agmatinase BtBc_28060 ENOG4105DXB Major Facilitator superfamily BtBc_28065 ENOG4107SWG transcriptional regulator MERR family BtBc_28070 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BtBc_28075 ENOG4105BZ4 penicillin-binding protein BtBc_28080 ENOG4108XFG YwhD family BtBc_28085 ENOG4108Z4T Peptidase M50 BtBc_28090 ENOG41069HH 4-oxalocrotonate tautomerase BtBc_28095 ENOG4105DCI Phosphohydrolase BtBc_28100 ENOG4108MES Periplasmic binding protein BtBc_28105 ENOG4105E0A ABC, transporter BtBc_28110 ENOG4105EHG Permease protein BtBc_28115 ENOG4105DQ5 transport system permease protein BtBc_28125 ENOG4108VCI transcription factor, rsfa family BtBc_28130 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BtBc_28135 ENOG4108IJ2 phosphate acetyltransferase BtBc_28140 ENOG4107UEZ chlorite dismutase BtBc_28150 ENOG4108VKI Cell wall hydrolase BtBc_28170 ENOG4107SVH Potassium channel protein BtBc_28180 ENOG410667J hydrolase BtBc_28185 ENOG4105VCH membrane BtBc_28195 ENOG4108TU7 Inherit from COG: (ABC) transporter BtBc_28200 ENOG4105CJ1 ABC, transporter BtBc_28205 ENOG41090WU lipolytic protein G-D-S-L family BtBc_28220 ENOG4105D6E homoserine dehydrogenase BtBc_28245 ENOG4108Y4K DNA-binding transcriptional activator BtBc_28255 ENOG4105WH1 Two component transcriptional regulator luxr family BtBc_28260 ENOG4105BZU Histidine kinase BtBc_28265 ENOG4105DWF phosphomethylpyrimidine kinase BtBc_28270 ENOG4105BZU Histidine kinase BtBc_28275 ENOG4105VCD cytoplasmic protein BtBc_28280 ENOG4105D22 carbon starvation protein BtBc_28285 ENOG4105DY9 regulatoR BtBc_28290 ENOG41079KZ Major Facilitator Superfamily BtBc_28300 ENOG4105CG5 Glycosyl transferase (Group 1 BtBc_28310 ENOG4105EN6 Membrane BtBc_28315 ENOG4106YBV Methyl-accepting chemotaxis BtBc_28325 ENOG4108S4H thioesterase Superfamily protein BtBc_28330 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BtBc_28345 ENOG4105K64 Glycosyl transferase, family 2 BtBc_28360 ENOG4105CKK Glycosyl transferase, family 2 BtBc_28365 ENOG4105C5H ABC transporter BtBc_28370 ENOG41067SE Tetr family transcriptional regulator BtBc_28380 ENOG4105E0X reductase BtBc_28385 ENOG4106F5Q Membrane BtBc_28400 ENOG4108NEV two component transcriptional regulator, LytTR family BtBc_28405 ENOG4108HRK Histidine kinase BtBc_28410 ENOG4107RGD Major Facilitator superfamily BtBc_28425 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BtBc_28435 ENOG4105IW1 AmiS UreI transporter BtBc_28440 ENOG4105CMR udp-glucose 4-epimerase BtBc_28445 ENOG4108UT2 hemolysin iii BtBc_28465 ENOG4105EKQ RNA-directed DNA polymerase BtBc_28480 ENOG4105C1J atp-dependent rna helicase BtBc_28485 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BtBc_28505 ENOG4105BZU Histidine kinase BtBc_28520 ENOG4105C0H protease BtBc_28525 ENOG4105Q2H domain protein BtBc_28540 ENOG4105BZU Histidine kinase BtBc_28545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BtBc_28570 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BtBc_28575 ENOG4105CDU Replicative dna helicase BtBc_28585 ENOG4105BZR domain protein BtBc_28590 ENOG4108XMW Membrane BtBc_28600 ENOG4108UUM single-stranded DNA-binding protein BtBc_28610 ENOG4105C3G gtp-binding protein BtBc_28615 ENOG4105VDK protein, conserved in bacteria BtBc_28620 ENOG4105D8X mechanosensitive ion channel BtBc_28625 ENOG4108ZDA Sporulation protein YyaC BtBc_28630 ENOG4105FA0 parb-like partition protein BtBc_28635 ENOG4107QJE Chromosome Partitioning Protein BtBc_28650 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BtBc_28655 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BtBc_28665 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BtBc_28800 ENOG4105FB9 CRISPR-associated protein BtBc_28860 ENOG4105EKQ RNA-directed DNA polymerase BtBc_28895 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BtBc_28945 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BtBc_28960 ENOG4108J59 Extracellular solute-binding protein, family 5 BtBc_28965 ENOG4105KRN Transcriptional regulator, abrb family BtBc_28980 ENOG4105K70 DNA-binding protein BtBc_28995 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BtBc_29000 ENOG4108FPN Integrase BtBc_29005 ENOG4108KU9 integrase family BtBc_29020 ENOG4107TSN permease BtBc_29065 ENOG4108WS4 fmn reductase BtBc_29070 ENOG4107V2S Transcriptional regulator BtBc_29090 ENOG410780I phosphoprotein phosphatase activity BtBc_29100 ENOG4108IBT Inherit from COG: transposase BtBc_29110 ENOG4105DHF Membrane BtBc_29155 ENOG4105EKQ RNA-directed DNA polymerase BtBc_29165 ENOG4105EKQ RNA-directed DNA polymerase BtBc_29180 ENOG4105EKQ RNA-directed DNA polymerase BtBc_29245 ENOG4105EKQ RNA-directed DNA polymerase BtBc_29395 ENOG4105EKQ RNA-directed DNA polymerase BtBc_29400 ENOG4105EKQ RNA-directed DNA polymerase BtBc_29410 ENOG4105EKQ RNA-directed DNA polymerase BtBc_29445 ENOG4105VIZ double-strand break repair protein BtBc_29450 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BtBc_29805 ENOG4105C9U ATP-dependent DNA helicase RecQ BtBc_29835 ENOG4105DQ6 Transposase BtBc_29865 ENOG4108J59 Extracellular solute-binding protein, family 5 BtBc_30125 ENOG4105EKQ RNA-directed DNA polymerase BtBc_30270 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BtBc_30280 ENOG410900G Protein of unknown function (DUF421) BtBc_30360 ENOG4105K4H Nlp p60 protein BtBc_30505 ENOG4105DR5 peptidase BtBc_30725 ENOG4105K4H Nlp p60 protein BtBc_30880 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BtBc_30935 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BtBc_31010 ENOG4108IBT Inherit from COG: transposase BtBc_31075 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BtBc_31085 ENOG410900G Protein of unknown function (DUF421)