locus-tag class description BTI247_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BTI247_00030 ENOG410848D S4 domain protein YaaA BTI247_00060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTI247_00130 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BTI247_00210 ENOG4105ZMH deoxynucleoside kinase BTI247_00230 ENOG4105GTG Isochorismatase BTI247_00240 ENOG4108Z6B deaminase BTI247_00260 ENOG4105C6E dna polymerase iii BTI247_00300 ENOG41067KS pro-sigma K processing BTI247_00370 ENOG4105CXN decarboxylase BTI247_00390 ENOG4105FA2 dna polymerase iii BTI247_00400 ENOG4105MA4 psp1 domain protein BTI247_00420 ENOG41060K3 Methyltransferase BTI247_00440 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BTI247_00450 ENOG4105KRN Transcriptional regulator, abrb family BTI247_00460 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BTI247_00470 ENOG4105F8V Hydrolase, tatD family BTI247_00480 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BTI247_00500 ENOG4105XFA sporulation peptidase YabG BTI247_00510 ENOG4105W42 Veg protein BTI247_00540 ENOG4105DFT pur operon repressor BTI247_00550 ENOG4105KME endoribonuclease L-psp BTI247_00580 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BTI247_00590 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BTI247_00610 ENOG4108JA2 transcriptioN-repair coupling factor BTI247_00620 ENOG4108M14 stage v sporulation protein t BTI247_00640 ENOG4108IY2 MazG family BTI247_00650 ENOG41082I2 s4 domain protein BTI247_00660 ENOG4105VYY sporulation protein yabp BTI247_00690 ENOG41060GV RNA binding s1 domain protein BTI247_00730 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BTI247_00740 ENOG4108UGV hypoxanthine phosphoribosyltransferase BTI247_00750 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BTI247_00780 ENOG4105C6T cysteine synthase BTI247_00790 ENOG4105CRQ synthase (Component I) BTI247_00800 ENOG4105DDQ anthranilate synthase BTI247_00810 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BTI247_00820 ENOG4105EEI dihydropteroate synthase BTI247_00830 ENOG4105KRF dihydroneopterin aldolase BTI247_00840 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BTI247_00860 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BTI247_01040 ENOG4108Z0C Uvrb UvrC protein BTI247_01070 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BTI247_01090 ENOG4105CTP PilT protein domain protein BTI247_01130 ENOG4105D7W serine acetyltransferase BTI247_01160 ENOG4105C2N RNA methyltransferase TrmH family group 3 BTI247_01170 ENOG4105M0M Tetracycline resistance protein BTI247_01180 ENOG4105QIV RNA polymerase BTI247_01200 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BTI247_01240 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BTI247_01250 ENOG4107Y49 methyltransferase BTI247_01270 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BTI247_01280 ENOG4105XPM ribosomal protein BTI247_01490 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BTI247_01540 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BTI247_01560 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BTI247_01580 ENOG41067V7 50S ribosomal protein L36 BTI247_01630 ENOG4108JJB ABC transporter BTI247_01640 ENOG4108JJB ABC transporter BTI247_01650 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BTI247_01660 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BTI247_01710 ENOG4105D1F ATP-binding protein BTI247_01740 ENOG4108NMV polysaccharide deacetylase BTI247_01900 ENOG4105C8B TIGR00159 family BTI247_01910 ENOG4107U5W ybbr family BTI247_01940 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BTI247_01990 ENOG4108PSK reductase BTI247_02000 ENOG4108UMI ABC transporter, permease BTI247_02010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTI247_02020 ENOG4105D01 (LipO)protein BTI247_02030 ENOG4105CB2 alcohol dehydrogenase BTI247_02050 ENOG4105IQ5 FAD linked oxidase domain protein BTI247_02080 ENOG4105C2C drug resistance transporter, Bcr CflA BTI247_02120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTI247_02130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTI247_02140 ENOG4105C3U ABC transporter BTI247_02150 ENOG4108JQ7 (ABC) transporter BTI247_02180 ENOG4108J59 Extracellular solute-binding protein, family 5 BTI247_02190 ENOG4108J59 Extracellular solute-binding protein, family 5 BTI247_02210 ENOG4105II7 pyrroline-5-carboxylate reductase BTI247_02220 ENOG4106Z1T Nicotinamide Mononucleotide Transporter BTI247_02240 ENOG4105E0C molybdate abc transporter BTI247_02250 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BTI247_02260 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BTI247_02290 ENOG4105EGI Transcriptional regulator BTI247_02320 ENOG4105F6E Acyl-transferase BTI247_02360 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BTI247_02400 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BTI247_02440 ENOG4105C5H ABC transporter BTI247_02460 ENOG4105DEF Extracellular solute-binding protein, family 5 BTI247_02480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTI247_02490 ENOG4105C3U ABC transporter BTI247_02500 ENOG4108JQ7 (ABC) transporter BTI247_02510 ENOG410667J hydrolase BTI247_02570 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BTI247_02580 ENOG4105ERH Fumarylacetoacetate hydrolase BTI247_02600 ENOG4105CUB amino acid BTI247_02610 ENOG4108SC4 )-transporter BTI247_02620 ENOG4105CPF Cell wall formation (By similarity) BTI247_02630 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BTI247_02680 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BTI247_02690 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BTI247_02710 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BTI247_02910 ENOG4105K8N protein family UPF0079, ATPase BTI247_02920 ENOG41072GX Peptidase M22 Glycoprotease BTI247_02930 ENOG410801F ribosomal-protein-alanine acetyltransferase BTI247_02940 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BTI247_02950 ENOG4105C5H ABC transporter BTI247_02980 ENOG4108TYN CAAX amino terminal protease family protein BTI247_03010 ENOG4107EV6 Inherit from COG: YD repeat protein BTI247_03040 ENOG4105C7N Xanthine uracil vitamin C permease BTI247_03060 ENOG4105BZU Histidine kinase BTI247_03110 ENOG4107ZXU DSBA oxidoreductase BTI247_03190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTI247_03280 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BTI247_03330 ENOG4105DQ6 Transposase BTI247_03360 ENOG4107RA4 Glycosyl transferase (Group 1 BTI247_03400 ENOG4105SX7 Transporter BTI247_03450 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BTI247_03460 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BTI247_03470 ENOG4105C83 adenylosuccinate lyase BTI247_03490 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BTI247_03540 ENOG4108V3E phosphoribosylglycinamide formyltransferase BTI247_03560 ENOG4105C12 Phosphoribosylglycinamide synthetase BTI247_03610 ENOG4105C4R Atp-dependent dna helicase BTI247_03620 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BTI247_03670 ENOG4108W2Y isochorismatase BTI247_03680 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTI247_03690 ENOG4108UMI ABC transporter, permease BTI247_03700 ENOG4105D01 (LipO)protein BTI247_03730 ENOG410834F Transcriptional regulator BTI247_03740 ENOG4107I77 yiaA/B two helix domain BTI247_03780 ENOG4105CBD Diacylglycerol kinase BTI247_03800 ENOG4108JPW Aminotransferase BTI247_03820 ENOG4105C26 Dehydrogenase BTI247_03830 ENOG4105KPY Small multidrug resistance protein BTI247_03910 ENOG4108IMY Transcriptional regulator BTI247_04000 ENOG4105WXW Antirepressor BTI247_04300 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BTI247_04380 ENOG4105D9N nucleoside BTI247_04390 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BTI247_04400 ENOG4105VTR Integrase BTI247_04450 ENOG41067QW Transcriptional regulator BTI247_04580 ENOG4105KRN Transcriptional regulator, abrb family BTI247_04710 ENOG410836F Transposase BTI247_04750 ENOG4105CNU cell division protein FtsK BTI247_04940 ENOG410836F Transposase BTI247_04980 ENOG410836F Transposase BTI247_05000 ENOG4105XSJ toxin secretion phage lysis holin BTI247_05060 ENOG4108W15 Protein of unknown function (DUF1456) BTI247_05090 ENOG4105DTQ mandelate racemase muconate lactonizing BTI247_05110 ENOG4105DFD Na H antiporter BTI247_05150 ENOG4105D3R alkyl hydroperoxide reductase BTI247_05160 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BTI247_05170 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BTI247_05180 ENOG4107W7X Aldolase BTI247_05200 ENOG4105EHG Permease protein BTI247_05210 ENOG4105DQ5 transport system permease protein BTI247_05220 ENOG4108V5C ABC transporter BTI247_05230 ENOG4105CAY ferredoxin--nadp reductase BTI247_05260 ENOG4106UIA BTI247_05270 ENOG4106UIA BTI247_05300 ENOG4105BZU Histidine kinase BTI247_05320 ENOG4105BZU Histidine kinase BTI247_05360 ENOG410756H nucleotidyltransferase BTI247_05370 ENOG4105D2S major facilitator superfamily BTI247_05410 ENOG4105E5Q amino acid AbC transporter BTI247_05420 ENOG4105EAB amino acid AbC transporter BTI247_05430 ENOG4105CDA abc transporter atp-binding protein BTI247_05440 ENOG4105C8Q Methyl-accepting chemotaxis BTI247_05470 ENOG4105DBV ornithine carbamoyltransferase BTI247_05490 ENOG4105C5B carbamate kinase BTI247_05500 ENOG4108W63 CRP FNR family transcriptional regulator BTI247_05520 ENOG4105DNP FAD linked oxidase domain protein BTI247_05540 ENOG4105CI1 PTS System BTI247_05570 ENOG4105C9U ATP-dependent DNA helicase RecQ BTI247_05600 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BTI247_05640 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BTI247_05650 ENOG4105D2X ABC transporter substrate-binding protein BTI247_05670 ENOG4105C5H ABC transporter BTI247_05730 ENOG41062JF Transcriptional regulator BTI247_05760 ENOG4105DEU major facilitator superfamily BTI247_05790 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BTI247_05830 ENOG4108N0M stress protein BTI247_05840 ENOG4106FN3 tellurium resistance protein BTI247_05850 ENOG4106FN3 tellurium resistance protein BTI247_05860 ENOG4107TS3 membrane protein, TerC BTI247_05870 ENOG4108TTB tellurium resistance protein BTI247_05900 ENOG41068PA UPF0435 protein BTI247_05910 ENOG4105KJF protein tyrosine phosphatase BTI247_05930 ENOG4107U9T Pfam:Ribonuclease_BN BTI247_05940 ENOG4105C59 p-type ATPase BTI247_05950 ENOG4108IPJ Membrane BTI247_05970 ENOG4105C3F Signal peptidase i BTI247_06000 ENOG4107ZTW SNARE associated Golgi BTI247_06030 ENOG410606W general stress protein BTI247_06040 ENOG4105UPD Calcium Proton BTI247_06110 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BTI247_06120 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BTI247_06140 ENOG4108JUB Transcriptional regulator BTI247_06160 ENOG4108IQI permease BTI247_06240 ENOG4108A04 Beta-lactamase BTI247_06270 ENOG4107R51 Glycosyl transferase, family 2 BTI247_06280 ENOG4107QQG Dehydrogenase BTI247_06290 ENOG4105C3I Nad-dependent epimerase dehydratase BTI247_06300 ENOG4105CKK Glycosyl transferase, family 2 BTI247_06320 ENOG4105F1A Pyruvate formate-lyase BTI247_06360 ENOG4105CI2 imidazolone-5-propionate hydrolase BTI247_06370 ENOG4105ECP epimerase BTI247_06430 ENOG41067AE Membrane-bound metal-dependent hydrolase BTI247_06440 ENOG4105CEN a g-specific adenine glycosylase BTI247_06450 ENOG4106BXE BTI247_06490 ENOG4105BZ1 (ABC) transporter BTI247_06500 ENOG4107NBY Membrane BTI247_06510 ENOG4105CBC glutamate synthase BTI247_06530 ENOG4108IUW ABC transporter BTI247_06570 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTI247_06580 ENOG4105G5W regulator Fur family BTI247_06820 ENOG4108JQC penicillin-binding protein 1A BTI247_06830 ENOG4108R9S DSBA oxidoreductase BTI247_06850 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BTI247_06870 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BTI247_06880 ENOG4105BZU Histidine kinase BTI247_06900 ENOG4105CYN Serine protein kinase BTI247_06940 ENOG4105C94 Transporter BTI247_06970 ENOG4105DZ6 Band 7 protein BTI247_06990 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BTI247_07000 ENOG4108V9W transcriptional regulatory protein BTI247_07010 ENOG410836F Transposase BTI247_07020 ENOG4105D4T Citrate transporter BTI247_07060 ENOG410836F Transposase BTI247_07080 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BTI247_07090 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTI247_07100 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BTI247_07110 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BTI247_07120 ENOG4105BZ7 extracellular solute-binding protein family 1 BTI247_07130 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BTI247_07140 ENOG4108STX response regulator BTI247_07150 ENOG4105US7 Histidine kinase BTI247_07200 ENOG4108MRH transcriptional regulatory protein BTI247_07220 ENOG4105C6K Malic enzyme BTI247_07240 ENOG4108UZ3 Transporter BTI247_07260 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTI247_07280 ENOG4105BZU Histidine kinase BTI247_07290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_07320 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BTI247_07330 ENOG4108JB9 formate dehydrogenase BTI247_07370 ENOG4105CUB amino acid BTI247_07400 ENOG4105C59 p-type ATPase BTI247_07410 ENOG4105DAP Nicotinate phosphoribosyltransferase BTI247_07480 ENOG41073R8 VanW family BTI247_07490 ENOG4108KGH TRANSCRIPTIONal BTI247_07500 ENOG4105D9N nucleoside BTI247_07510 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BTI247_07520 ENOG4105C37 (CBS) domain BTI247_07530 ENOG4108IJ0 Aspartate ammonia-lyase BTI247_07540 ENOG4105DAA L-lactate BTI247_07570 ENOG4105DUX Transporter BTI247_07580 ENOG4108MES Periplasmic binding protein BTI247_07590 ENOG4105DQ5 transport system permease protein BTI247_07600 ENOG4108IHU transport system permease protein BTI247_07610 ENOG4105E0A ABC, transporter BTI247_07640 ENOG4105EXW epimerase dehydratase BTI247_07660 ENOG4107T89 von Willebrand factor, type A BTI247_07670 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BTI247_07680 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTI247_07700 ENOG4105BZU Histidine kinase BTI247_07710 ENOG4105D5Q Arginine ornithine antiporter BTI247_07720 ENOG4107414 GntR family transcriptional regulator BTI247_07730 ENOG4105C5Y PTS System BTI247_07740 ENOG4105CG3 alpha amylase, catalytic region BTI247_07780 ENOG4105E1K spore germination protein BTI247_07790 ENOG4108XG2 Histidine kinase BTI247_07800 ENOG4105WH1 Two component transcriptional regulator luxr family BTI247_07810 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BTI247_07830 ENOG4105CRN Aminoglycoside phosphotransferase BTI247_07840 ENOG4105BZG amino acid carrier protein BTI247_07850 ENOG4105CDA abc transporter atp-binding protein BTI247_07860 ENOG4105CT1 (ABC) transporter BTI247_07870 ENOG4105EAD ABC transporter BTI247_07880 ENOG4105DRP amino acid AbC transporter BTI247_07890 ENOG4108IQI permease BTI247_07920 ENOG4105D29 Helix-turn-helix type 11 domain protein BTI247_07930 ENOG4105NAE bifunctional deaminase-reductase domain protein BTI247_07940 ENOG4105BZU Histidine kinase BTI247_07970 ENOG4105CHH sulfate transporter BTI247_07980 ENOG41068KF Universal stress protein BTI247_08000 ENOG4105DEF Extracellular solute-binding protein, family 5 BTI247_08020 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTI247_08030 ENOG4108JQ7 (ABC) transporter BTI247_08050 ENOG4105CXY transporter BTI247_08060 ENOG41067TZ transcriptional regulator, MarR family BTI247_08070 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTI247_08080 ENOG4105ETE Transcriptional regulator (LacI family BTI247_08090 ENOG4108RVA ribokinase BTI247_08110 ENOG4105C2J ABC transporter BTI247_08120 ENOG4105CNN ABC, transporter BTI247_08130 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BTI247_08140 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BTI247_08240 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BTI247_08580 ENOG4105CAR Terminase, large subunit BTI247_08600 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BTI247_08740 ENOG4105XSJ toxin secretion phage lysis holin BTI247_08790 ENOG4105CNU cell division protein FtsK BTI247_08870 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BTI247_08880 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTI247_08890 ENOG41069ER domain protein BTI247_08900 ENOG4105VZ8 Transcriptional regulator BTI247_08910 ENOG4107D63 BTI247_08950 ENOG4105DUX Transporter BTI247_09000 ENOG4105C85 amino acid BTI247_09010 ENOG4105C7N Xanthine uracil vitamin C permease BTI247_09030 ENOG4105D7V transposase BTI247_09060 ENOG4105MA6 gCN5-related N-acetyltransferase BTI247_09110 ENOG4105BZ9 Cytochrome C oxidase, subunit I BTI247_09120 ENOG4105E2S oxidase) subunit II BTI247_09160 ENOG4106CAD Protein of unknown function (DUF3311) BTI247_09170 ENOG4105E1V na solute symporter BTI247_09200 ENOG4108NHD germination protein BTI247_09210 ENOG4105CE1 Ferrous iron transport protein b BTI247_09220 ENOG4105CE1 Ferrous iron transport protein b BTI247_09230 ENOG4105CE1 Ferrous iron transport protein b BTI247_09240 ENOG4105CVA phosphate BTI247_09250 ENOG4105C8U phosphate abc transporter BTI247_09260 ENOG4105E2Z phosphate ABC transporter (Permease BTI247_09520 ENOG41080XQ Signal transduction protein with cbs domains BTI247_09560 ENOG4105ETU transcriptional activator (TenA BTI247_09590 ENOG4105DQ6 Transposase BTI247_09610 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BTI247_09630 ENOG4108VEU Thiamine monophosphate synthase BTI247_09640 ENOG41080HI glycine oxidase BTI247_09670 ENOG4105D06 uba thif-type nad fad binding protein BTI247_09680 ENOG4105DWF phosphomethylpyrimidine kinase BTI247_09740 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BTI247_09770 ENOG4108INS Transcriptional regulator BTI247_09800 ENOG4105CNN ABC, transporter BTI247_09830 ENOG4105C7N Xanthine uracil vitamin C permease BTI247_09850 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BTI247_09880 ENOG4105K63 Thioredoxin BTI247_09920 ENOG4108B31 Spore germination protein BTI247_09960 ENOG4107Y03 Nitroreductase BTI247_09970 ENOG4105ED1 spovr family BTI247_09980 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 BTI247_10000 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BTI247_10010 ENOG4105XTG Pfam:DUF156 BTI247_10020 ENOG4105VFE sira family BTI247_10030 ENOG4107TPS domain protein BTI247_10040 ENOG4105VFE sira family BTI247_10070 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BTI247_10080 ENOG41087NI Sulfite exporter TauE/SafE BTI247_10100 ENOG4108KGH TRANSCRIPTIONal BTI247_10150 ENOG4105EMD TRANSCRIPTIONal BTI247_10160 ENOG4105VCP PTS System BTI247_10170 ENOG4105VZJ PTS System BTI247_10210 ENOG41069ER domain protein BTI247_10220 ENOG4107RBB ABC transporter, permease BTI247_10230 ENOG4105C19 ABC transporter BTI247_10290 ENOG4105WEF catalase BTI247_10360 ENOG4107T5V SNARE associated Golgi BTI247_10430 ENOG4105CUB amino acid BTI247_10440 ENOG4107RWR Sodium hydrogen exchanger BTI247_10460 ENOG4106KNT transcriptional regulator BTI247_10470 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BTI247_10550 ENOG4108YXU transcriptional regulator AsnC family BTI247_10570 ENOG4105CH7 arginosuccinase BTI247_10580 ENOG4108IXY short-chain dehydrogenase reductase BTI247_10610 ENOG4105KPY Small multidrug resistance protein BTI247_10670 ENOG4105NF4 modulator of drug activity BTI247_10690 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BTI247_10700 ENOG4105E5W Transporter BTI247_10720 ENOG4107RKG DJ-1/PfpI family BTI247_10740 ENOG4105D5Q Arginine ornithine antiporter BTI247_10780 ENOG4105C26 Dehydrogenase BTI247_10790 ENOG4105BZ1 (ABC) transporter BTI247_10800 ENOG4105BZ1 (ABC) transporter BTI247_10820 ENOG4105DRP amino acid AbC transporter BTI247_10830 ENOG4105CDA abc transporter atp-binding protein BTI247_10860 ENOG410839P BTI247_10880 ENOG4108UH6 UPF0754 membrane protein BTI247_10940 ENOG4107FQX Alpha-acetolactate decarboxylase BTI247_10980 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTI247_11000 ENOG4105D4P Coproporphyrinogen iii oxidase BTI247_11010 ENOG4105CEY Amp-dependent synthetase and ligase BTI247_11040 ENOG4105CHH sulfate transporter BTI247_11090 ENOG4105CGU Enoyl-CoA hydratase BTI247_11130 ENOG4105DER m42 family BTI247_11170 ENOG4105CTU Proline racemase BTI247_11180 ENOG4105CIF Ornithine Cyclodeaminase BTI247_11220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTI247_11240 ENOG4108JQ7 (ABC) transporter BTI247_11300 ENOG4105CSH Transporter BTI247_11320 ENOG4108MRH transcriptional regulatory protein BTI247_11410 ENOG4105CVR type I restriction-modification system BTI247_11430 ENOG4105DZR Type I site-specific deoxyribonuclease BTI247_11590 ENOG4105CDU Replicative dna helicase BTI247_11650 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTI247_11700 ENOG4105F6J Alpha beta hydrolase fold BTI247_11780 ENOG410836F Transposase BTI247_11800 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BTI247_11820 ENOG4105F27 Major Facilitator BTI247_11830 ENOG4105WAB arsR family transcriptional regulator BTI247_11850 ENOG4105CMT Dihydroxyacetone kinase BTI247_11870 ENOG4105CMT Dihydroxyacetone kinase BTI247_12070 ENOG4105WN5 stage II sporulation protein BTI247_12090 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTI247_12110 ENOG4108MJI response regulator BTI247_12120 ENOG4105BZU Histidine kinase BTI247_12130 ENOG4105BZU Histidine kinase BTI247_12140 ENOG4105DQ6 Transposase BTI247_12200 ENOG4105K8R UPF0145 protein BTI247_12240 ENOG4107QHE Choloylglycine hydrolase BTI247_12280 ENOG4107VRP DNA repair exonuclease BTI247_12290 ENOG4106D4I domain protein BTI247_12310 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTI247_12560 ENOG4106E8G BTI247_12770 ENOG4105XSJ toxin secretion phage lysis holin BTI247_12780 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BTI247_12870 ENOG410829K Lysine exporter protein (Lyse ygga) BTI247_12920 ENOG4108MUZ hydrolase BTI247_12950 ENOG4105F0F Oxalate decarboxylase BTI247_12960 ENOG41067QW Transcriptional regulator BTI247_12970 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BTI247_13000 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BTI247_13050 ENOG4105EMN RNA polymerase sigma factor BTI247_13100 ENOG4105EEM helicase BTI247_13120 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTI247_13170 ENOG4105K59 histidine triad (HIT) protein BTI247_13290 ENOG410905X membrane-flanked domain protein BTI247_13300 ENOG4105CKV Membrane BTI247_13410 ENOG410905X membrane-flanked domain protein BTI247_13420 ENOG4105CKV Membrane BTI247_13430 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BTI247_13440 ENOG4105BZ4 penicillin-binding protein BTI247_13460 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BTI247_13470 ENOG4105C1Q protoporphyrinogen oxidase BTI247_13530 ENOG4105NA0 Transcriptional regulator BTI247_13560 ENOG4105ECB domain protein BTI247_13620 ENOG4106AXD BTI247_13630 ENOG4108RQ5 Beta-lactamase domain-containing protein BTI247_13640 ENOG4105DF9 Lipoate-protein, ligase BTI247_13660 ENOG4105CEY Amp-dependent synthetase and ligase BTI247_13680 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BTI247_13690 ENOG4108I5D sulfate abc transporter BTI247_13700 ENOG4105ECW sulfate abc transporter BTI247_13710 ENOG4108IJ6 ABC transporter BTI247_13750 ENOG4105CNA YD repeat protein BTI247_13860 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BTI247_13870 ENOG4107RN3 metallophosphoesterase BTI247_13890 ENOG4107TVP HD domain protein BTI247_13910 ENOG4108AEY RNA polymerase sigma factor BTI247_13920 ENOG41086D8 Transcriptional regulator BTI247_13960 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTI247_14000 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BTI247_14010 ENOG4105C8Q Methyl-accepting chemotaxis BTI247_14020 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) BTI247_14040 ENOG4107QP3 malate synthase g BTI247_14080 ENOG4105VEQ Cold shock protein BTI247_14130 ENOG4105XVF Competence transcription factor BTI247_14170 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BTI247_14180 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BTI247_14260 ENOG4105ERH Fumarylacetoacetate hydrolase BTI247_14280 ENOG4105C8Y Acetylornithine aminotransferase BTI247_14290 ENOG4106BKT UPF0344 protein BTI247_14310 ENOG4105CAQ asparagine synthetase BTI247_14320 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BTI247_14330 ENOG4105CH6 catalase BTI247_14340 ENOG4105BZU Histidine kinase BTI247_14380 ENOG4105QNR S1 RNA binding domain protein BTI247_14430 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTI247_14450 ENOG4107AYK membrAne BTI247_14460 ENOG41073B9 BTI247_14480 ENOG4108KP7 hydrolase BTI247_14500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BTI247_14550 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BTI247_14560 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BTI247_14590 ENOG4105C31 Tryptophanyl-tRNA synthetase BTI247_14630 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTI247_14640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTI247_14660 ENOG4108JQ7 (ABC) transporter BTI247_14670 ENOG4105UQX Mate efflux family protein BTI247_14680 ENOG4105UQX Mate efflux family protein BTI247_14720 ENOG4108ZCF integral membrane protein BTI247_14740 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTI247_14760 ENOG4105DPN Oligoendopeptidase f BTI247_14780 ENOG4108Z18 K06886 hemoglobin BTI247_14790 ENOG4105MIX Adenylate cyclase BTI247_14800 ENOG4106EFP UPF0738 protein BTI247_14820 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BTI247_14830 ENOG4105EMS pseudouridine synthase BTI247_14870 ENOG4105K64 Glycosyl transferase, family 2 BTI247_14910 ENOG4107TVC Glycosyl transferase, family 2 BTI247_14950 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BTI247_14960 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BTI247_14980 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BTI247_15120 ENOG4105CK7 Sodium proline symporter BTI247_15150 ENOG4105CRQ synthase (Component I) BTI247_15160 ENOG4105DDQ anthranilate synthase BTI247_15170 ENOG4108I0Q anthranilate phosphoribosyltransferase BTI247_15190 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BTI247_15200 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BTI247_15210 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BTI247_15360 ENOG4105C7S Dehydrogenase BTI247_15370 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BTI247_15380 ENOG4105VZ8 Transcriptional regulator BTI247_15430 ENOG4108IUX (ABC) transporter BTI247_15440 ENOG4105RHA ABC transporter, permease BTI247_15550 ENOG4105DQ6 Transposase BTI247_15600 ENOG4105DQ6 Transposase BTI247_15670 ENOG4108NE4 BTI247_15700 ENOG4108HE4 integrase family BTI247_15760 ENOG4105DZ1 carboxypeptidase BTI247_15770 ENOG4105VFR signal peptidase BTI247_15840 ENOG4105C26 Dehydrogenase BTI247_15850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTI247_15860 ENOG4105F38 ABC transporter, permease BTI247_15870 ENOG4105D38 putrescine abc transporter BTI247_15880 ENOG4107RUE extracellular solute-binding protein family 1 BTI247_15900 ENOG4105EYF MMPL domain protein BTI247_15920 ENOG4108YBP pseudouridine synthase BTI247_15940 ENOG4105K4I Scp-like extracellular BTI247_15950 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BTI247_15960 ENOG4105DQ6 Transposase BTI247_15980 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BTI247_15990 ENOG4105CQB FAD linked oxidase domain protein BTI247_16020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_16030 ENOG4105BZU Histidine kinase BTI247_16040 ENOG4105JXH GntR family transcriptional regulator BTI247_16080 ENOG4106A3R peptidase BTI247_16100 ENOG4108QTI )-transporter BTI247_16110 ENOG4107TS3 membrane protein, TerC BTI247_16120 ENOG4105CZN Potassium uptake protein BTI247_16130 ENOG410681C small acid-soluble spore protein BTI247_16140 ENOG4108Z7G MaoC domain protein dehydratase BTI247_16180 ENOG4105CHR reductase BTI247_16240 ENOG4105C4Y ABC transporter BTI247_16250 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTI247_16260 ENOG4107RCV ABC transporter, permease BTI247_16330 ENOG4105E98 transcriptional regulator DeoR family BTI247_16360 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BTI247_16380 ENOG4105PXI polysaccharide deacetylase BTI247_16400 ENOG4105BZU Histidine kinase BTI247_16410 ENOG41090MY MarR family Transcriptional regulator BTI247_16430 ENOG4106DF1 BTI247_16450 ENOG4105BZU Histidine kinase BTI247_16460 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BTI247_16470 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BTI247_16480 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BTI247_16560 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BTI247_16570 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BTI247_16580 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BTI247_16590 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BTI247_16600 ENOG4105CZV ABC transporter BTI247_16620 ENOG4105CJ1 ABC, transporter BTI247_16700 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BTI247_16710 ENOG4105EA8 2-Nitropropane dioxygenase BTI247_16720 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BTI247_16740 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BTI247_16790 ENOG4105NQC Flavodoxin BTI247_16840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BTI247_16900 ENOG4105CZN Potassium uptake protein BTI247_16910 ENOG41063Y9 BTI247_16920 ENOG4105KBJ sporulation protein ytfj BTI247_16960 ENOG4105CM2 brancheD-chain amino acid aminotransferase BTI247_16980 ENOG4105C7K acetolactate synthase BTI247_16990 ENOG4108ZP8 Acetolactate synthase small subunit BTI247_17000 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BTI247_17030 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BTI247_17070 ENOG4105DQ6 Transposase BTI247_17090 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BTI247_17100 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BTI247_17110 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BTI247_17160 ENOG4107RVV histidinol phosphate phosphatase, hisj family BTI247_17190 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BTI247_17200 ENOG4105E0M Sulfatase BTI247_17230 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BTI247_17270 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BTI247_17280 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BTI247_17300 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BTI247_17310 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BTI247_17320 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BTI247_17340 ENOG4105C8J )-transporter BTI247_17390 ENOG4105DFD Na H antiporter BTI247_17430 ENOG4105ENE Histidine kinase BTI247_17440 ENOG4105WH1 Two component transcriptional regulator luxr family BTI247_17490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTI247_17540 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BTI247_17580 ENOG4105CJ3 phosphate transporter BTI247_17590 ENOG4107GRR phosphate transport regulator BTI247_17600 ENOG4105BZ4 penicillin-binding protein BTI247_17630 ENOG4105BZU Histidine kinase BTI247_17640 ENOG4105I3N Conserved Protein BTI247_17670 ENOG4105BZU Histidine kinase BTI247_17730 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTI247_17740 ENOG4105DZ1 carboxypeptidase BTI247_17750 ENOG4108JIC nucleoside recognition domain protein BTI247_17770 ENOG4105FE9 pseudouridine synthase BTI247_17780 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTI247_17790 ENOG4107TWT Cytochrome c biogenesis protein BTI247_17800 ENOG4105CRE cytochrome C BTI247_17810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_17820 ENOG4105BZU Histidine kinase BTI247_17830 ENOG4108WBT adenosyltransferase BTI247_17870 ENOG4108SAX Membrane BTI247_17900 ENOG4105C9U ATP-dependent DNA helicase RecQ BTI247_17910 ENOG4105I7S Abortive infection protein BTI247_17930 ENOG4107RGJ metallophosphoesterase BTI247_17940 ENOG4108XDN Transcriptional regulator BTI247_17950 ENOG4108S6Z Negative regulator of genetic competence BTI247_18000 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BTI247_18010 ENOG4107RB3 L-asparaginase BTI247_18080 ENOG4105S2F BTI247_18090 ENOG41065D1 BTI247_18150 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BTI247_18180 ENOG4105XXQ heptaprenyl diphosphate synthase component I BTI247_18200 ENOG4105EAH synthase BTI247_18210 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BTI247_18220 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BTI247_18250 ENOG41068YB TPR repeat-containing protein BTI247_18280 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BTI247_18290 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BTI247_18360 ENOG4108JYZ YitT family BTI247_18370 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BTI247_18400 ENOG4105FJR Lmbe family BTI247_18410 ENOG4105CPK Glycosyl transferase (Group 1 BTI247_18450 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BTI247_18480 ENOG4105DVT helicase BTI247_18490 ENOG4105YAC BTI247_18530 ENOG4105CSM endonuclease III BTI247_18550 ENOG4105BZ4 penicillin-binding protein BTI247_18670 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BTI247_18690 ENOG4105DVT helicase BTI247_18700 ENOG4105CTD carboxy-peptidase BTI247_18720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BTI247_18740 ENOG4105C2W permease BTI247_18760 ENOG410836F Transposase BTI247_18770 ENOG4105DHF Membrane BTI247_18790 ENOG410890F Dynamin family BTI247_18810 ENOG4108W0I acetyltransferase BTI247_18830 ENOG4105KHC sulfurtransferase BTI247_18930 ENOG4105HTX biosynthesis protein BTI247_18990 ENOG4105CPK Glycosyl transferase (Group 1 BTI247_19000 ENOG410607W Transposase BTI247_19030 ENOG4108SZE gCN5-related N-acetyltransferase BTI247_19070 ENOG41081VK Ribonuclease BTI247_19200 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTI247_19220 ENOG4107RWR Sodium hydrogen exchanger BTI247_19230 ENOG4108Z5V transcriptional regulator, merr family BTI247_19250 ENOG4105H67 Protein of unknown function (DUF421) BTI247_19260 ENOG41080C8 DUF218 domain BTI247_19360 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTI247_19380 ENOG4107R0U MotA TolQ exbB proton channel BTI247_19390 ENOG4105ER2 Ompa motb domain protein BTI247_19400 ENOG4107YTP response regulator receiver protein BTI247_19410 ENOG4105CBS Chea signal transduction histidine kinase BTI247_19420 ENOG4105DD5 Flagellar motor switch protein BTI247_19450 ENOG4105BZU Histidine kinase BTI247_19470 ENOG4105BZU Histidine kinase BTI247_19510 ENOG4105E1Q flagellar hook-associated protein BTI247_19520 ENOG4105DTJ flagellar hook-associated protein BTI247_19560 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BTI247_19570 ENOG4108ZC9 flagellar basal-body rod protein flgc BTI247_19580 ENOG41075Z6 flagellar hook-basal body complex protein fliE BTI247_19590 ENOG4107U2N Flagellar M-ring protein BTI247_19600 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BTI247_19660 ENOG4105BZE flagellar hook protein, FlgE BTI247_19690 ENOG4107R88 Chemotaxis protein (CheV) BTI247_19710 ENOG4105I03 Flagellin BTI247_19720 ENOG4105I03 Flagellin BTI247_19730 ENOG4105E4C Lytic transglycosylase catalytic BTI247_19750 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BTI247_19760 ENOG4105DD5 Flagellar motor switch protein BTI247_19780 ENOG4105CN7 Flagellar biosynthetic protein FliP BTI247_19790 ENOG4105VS8 Flagellar biosynthetic protein fliq BTI247_19810 ENOG4105D00 flagellar biosynthetic protein flhB BTI247_19820 ENOG4105D7B Flagellar biosynthesis protein flha BTI247_19830 ENOG4105FZW flagellar biosynthesis regulator FlhF BTI247_19860 ENOG4105KTQ flagellar basal-body rod protein BTI247_19880 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTI247_19940 ENOG4105KAC Antibiotic biosynthesis monooxygenase BTI247_19950 ENOG4107QZ7 Cellulose synthase catalytic subunit BTI247_20000 ENOG4105DUM transcriptional regulator, lysR family BTI247_20010 ENOG410836F Transposase BTI247_20020 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTI247_20040 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BTI247_20120 ENOG4105CVJ phosphoglycerate mutase BTI247_20140 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BTI247_20180 ENOG4105CAQ asparagine synthetase BTI247_20220 ENOG4105PGM cation diffusion facilitator family transporter BTI247_20240 ENOG4105DRR Transcriptional regulator, GntR family BTI247_20250 ENOG4108UZ3 Transporter BTI247_20270 ENOG4105CKI cobalamin synthesis protein BTI247_20280 ENOG4108PJD permease BTI247_20310 ENOG4105DFD Na H antiporter BTI247_20320 ENOG4105VUF Transcriptional regulator BTI247_20340 ENOG4105C9Q fumarate hydratase class II BTI247_20370 ENOG4107QJQ Mate efflux family protein BTI247_20380 ENOG4105EC3 peptidase S51, dipeptidase E BTI247_20420 ENOG4107QIV Cytochrome c biogenesis protein BTI247_20430 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTI247_20460 ENOG4107JM4 Tetratricopeptide repeat BTI247_20490 ENOG4105BZC d-serine deaminase BTI247_20500 ENOG4106BRA Membrane BTI247_20550 ENOG4105WH1 Two component transcriptional regulator luxr family BTI247_20570 ENOG4105CJ1 ABC, transporter BTI247_20620 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BTI247_20640 ENOG4108IJ0 Aspartate ammonia-lyase BTI247_20650 ENOG4105C6K Malic enzyme BTI247_20790 ENOG4105FVX BTI247_20800 ENOG4105E09 nadh pyrophosphatase BTI247_20840 ENOG4105CSR polyphosphate kinase 2 BTI247_20850 ENOG410836F Transposase BTI247_20860 ENOG4105U3E Transcriptional regulator BTI247_20880 ENOG4105DXI Major Facilitator superfamily BTI247_20910 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BTI247_20920 ENOG4105EU0 Major facilitator Superfamily BTI247_20930 ENOG4105C6T cysteine synthase BTI247_20980 ENOG4105C8J )-transporter BTI247_21010 ENOG4105X5K response regulator receiver protein BTI247_21020 ENOG4105H67 Protein of unknown function (DUF421) BTI247_21070 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BTI247_21080 ENOG4105CHR reductase BTI247_21090 ENOG4105CM2 brancheD-chain amino acid aminotransferase BTI247_21100 ENOG4105C7K acetolactate synthase BTI247_21120 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BTI247_21140 ENOG4105C7B Threonine dehydratase BTI247_21180 ENOG4105C6X Major Facilitator BTI247_21190 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BTI247_21210 ENOG4105DY9 regulatoR BTI247_21220 ENOG4105CYC Transferase BTI247_21230 ENOG4105K5X acetyltransferase BTI247_21250 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BTI247_21270 ENOG41068WN BTI247_21310 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BTI247_21340 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BTI247_21360 ENOG4105C0X amino acid BTI247_21450 ENOG410849A acetyltransferase, (GNAT) family BTI247_21460 ENOG4105K8R UPF0145 protein BTI247_21470 ENOG4108TYN CAAX amino terminal protease family protein BTI247_21490 ENOG4107RHR regulatoR BTI247_21510 ENOG4105D9N nucleoside BTI247_21520 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BTI247_21530 ENOG4105KG3 cytidine deaminase BTI247_21580 ENOG410811B TRANSCRIPTIONal BTI247_21620 ENOG4107RAQ aminopeptidase BTI247_21650 ENOG4107R16 Multicopper oxidase BTI247_21690 ENOG410836F Transposase BTI247_21740 ENOG4108T5E Copper resistance protein BTI247_21750 ENOG4105KTB nuclear export factor GLE1 BTI247_21760 ENOG4107RT3 EamA-like transporter family BTI247_21770 ENOG4105GZI Transcriptional regulator BTI247_21780 ENOG4108Z40 Transcriptional regulator BTI247_21790 ENOG4107ZXU DSBA oxidoreductase BTI247_21800 ENOG4108TVJ Nitroreductase BTI247_21840 ENOG4105D7V transposase BTI247_21850 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BTI247_21860 ENOG4106F5Q Membrane BTI247_21870 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BTI247_21890 ENOG4105CKI cobalamin synthesis protein BTI247_21910 ENOG4105C0Z ABC transporter BTI247_21920 ENOG4108IV0 ABC, transporter BTI247_21930 ENOG4105C32 Amino acid ABC transporter (Permease) BTI247_21950 ENOG410836F Transposase BTI247_21960 ENOG4105EGI Transcriptional regulator BTI247_21980 ENOG4105MDS 4-oxalocrotonate tautomerase BTI247_22020 ENOG4105C4M (Ubiquinol oxidase) subunit I BTI247_22030 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BTI247_22040 ENOG4108JJ9 ABC, transporter BTI247_22050 ENOG4108JJ8 (ABC) transporter BTI247_22070 ENOG4105K64 Glycosyl transferase, family 2 BTI247_22090 ENOG4108UT6 Transferase hexapeptide repeat containing protein BTI247_22210 ENOG4105DQ6 Transposase BTI247_22240 ENOG4105BZ1 (ABC) transporter BTI247_22250 ENOG4105EFI regulatoR BTI247_22260 ENOG4105BZU Histidine kinase BTI247_22270 ENOG4105BZU Histidine kinase BTI247_22310 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BTI247_22320 ENOG4108ZJ4 polysaccharide deacetylase BTI247_22380 ENOG4105D6E homoserine dehydrogenase BTI247_22400 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BTI247_22430 ENOG4108KGH TRANSCRIPTIONal BTI247_22450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTI247_22460 ENOG4105BZU Histidine kinase BTI247_22470 ENOG4107VMI polysaccharide deacetylase BTI247_22490 ENOG4105KT7 mgtC SapB transporter BTI247_22500 ENOG4105VRR gCN5-related N-acetyltransferase BTI247_22520 ENOG4105DUU IucA IucC family protein BTI247_22530 ENOG4105CEY Amp-dependent synthetase and ligase BTI247_22560 ENOG4108WBH protein TIM barrel BTI247_22570 ENOG4105YWU small acid-soluble spore protein BTI247_22590 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BTI247_22600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTI247_22700 ENOG4105KRN Transcriptional regulator, abrb family BTI247_22720 ENOG4105YVS arsR family transcriptional regulator BTI247_22730 ENOG4105CPC Aldo Keto reductase BTI247_22740 ENOG4107XZQ multidrug resistance protein BTI247_22750 ENOG4107XZQ multidrug resistance protein BTI247_22800 ENOG4105C8Q Methyl-accepting chemotaxis BTI247_22830 ENOG4108K88 Membrane BTI247_22840 ENOG4108WPJ Ferritin-like domain BTI247_22870 ENOG4105DEN Luciferase family BTI247_22900 ENOG4105VMI -acetyltransferase BTI247_22910 ENOG4107QM2 Aldo Keto reductase BTI247_22930 ENOG4105CKI cobalamin synthesis protein BTI247_22950 ENOG4105DSE periplasmic solute binding protein BTI247_22970 ENOG4105K4T epimerase BTI247_22990 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BTI247_23090 ENOG4107T5V SNARE associated Golgi BTI247_23120 ENOG4108PJD permease BTI247_23140 ENOG4108S4H thioesterase Superfamily protein BTI247_23150 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTI247_23190 ENOG4105SXS Protein of unknown function (DUF456) BTI247_23200 ENOG4105C37 (CBS) domain BTI247_23260 ENOG4108Z7R Chaperone CsaA BTI247_23300 ENOG4108ZRV stage ii sporulation protein p BTI247_23320 ENOG4108VXD carboxy-peptidase BTI247_23380 ENOG4108ZRV stage ii sporulation protein p BTI247_23400 ENOG4108X4Q Hydrolase BTI247_23410 ENOG41082F9 transcriptional regulator BTI247_23420 ENOG4105D94 Major Facilitator Superfamily BTI247_23440 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BTI247_23450 ENOG4107RBS Methyltransferase BTI247_23480 ENOG41087PP glycosyltransferase MGT family BTI247_23490 ENOG4108JYZ YitT family BTI247_23500 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTI247_23560 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BTI247_23610 ENOG4105KBJ sporulation protein ytfj BTI247_23660 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTI247_23700 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BTI247_23710 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BTI247_23730 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BTI247_23740 ENOG4105EMN RNA polymerase sigma factor BTI247_23770 ENOG4105CNW domain protein BTI247_23790 ENOG4108V06 Glutathione peroxidase BTI247_23820 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BTI247_23840 ENOG4108IUE nitrate reductase beta subunit BTI247_23850 ENOG4105R3A Nitrate reductase BTI247_23870 ENOG4107V6Q Cyclic nucleotide-binding domain BTI247_23880 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BTI247_23890 ENOG4105D06 uba thif-type nad fad binding protein BTI247_23900 ENOG4105D06 uba thif-type nad fad binding protein BTI247_23910 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTI247_23920 ENOG4108ZAF Molybdopterin BTI247_23970 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BTI247_23980 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BTI247_23990 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BTI247_24000 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BTI247_24010 ENOG4108IFG nitrite reductase, (NAD(P)H) BTI247_24020 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BTI247_24090 ENOG4105MCT stage V sporulation protein S BTI247_24140 ENOG4105C5H ABC transporter BTI247_24170 ENOG4108UUM single-stranded DNA-binding protein BTI247_24220 ENOG4107YX5 Pfam:DUF548 BTI247_24240 ENOG4105C75 arginyL-tRNA synthetase BTI247_24280 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BTI247_24330 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BTI247_24350 ENOG4105C5S asparaginyl-tRNA synthetase BTI247_24410 ENOG4105EC2 ftsk spoIIIe BTI247_24500 ENOG4105C8J )-transporter BTI247_24540 ENOG4107XGZ Hydrolase BTI247_24550 ENOG4105CY2 Citrate transporter BTI247_24590 ENOG4105KD7 acetyltransferase BTI247_24610 ENOG4105VMP Transcriptional regulator BTI247_24620 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BTI247_24670 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BTI247_24690 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BTI247_24720 ENOG4107RVG penicillin-binding protein BTI247_24740 ENOG4105E9Q Acyl-transferase BTI247_24750 ENOG4108UT2 hemolysin iii BTI247_24770 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BTI247_24790 ENOG4108RCR degv family BTI247_24810 ENOG4108KF3 Electron transport protein SCO1 SenC BTI247_24820 ENOG4107Y70 Heat shock protein BTI247_24830 ENOG4105CAQ asparagine synthetase BTI247_24860 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BTI247_24870 ENOG4108MES Periplasmic binding protein BTI247_24880 ENOG4105F0I Aminotransferase BTI247_24890 ENOG4108DBC nitroreductase BTI247_24930 ENOG4105D8X mechanosensitive ion channel BTI247_24940 ENOG4105BZU Histidine kinase BTI247_24950 ENOG4105WH1 Two component transcriptional regulator luxr family BTI247_24960 ENOG4106KNT transcriptional regulator BTI247_24970 ENOG4107ZY0 Phenazine biosynthesis-like protein BTI247_25020 ENOG4105CMG Carbohydrate kinase BTI247_25030 ENOG4105C6Z Gluconate BTI247_25050 ENOG4108YV3 Protein of unknown function (DUF2711) BTI247_25110 ENOG4108IJ8 ABC transporter BTI247_25120 ENOG4105E90 ABC transporter BTI247_25190 ENOG4105C37 (CBS) domain BTI247_25240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTI247_25270 ENOG4107S4Y M20 DapE family protein YgeY BTI247_25280 ENOG4108TSC N-acetyltransferase BTI247_25290 ENOG4108JUB Transcriptional regulator BTI247_25300 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BTI247_25390 ENOG410841Q phosphoesterase PA-phosphatase related protein BTI247_25420 ENOG4105SZ6 Thioredoxin BTI247_25430 ENOG4105KNA -acetyltransferase BTI247_25520 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTI247_25650 ENOG4105BZ4 penicillin-binding protein BTI247_25670 ENOG4105CZM Major Facilitator BTI247_25680 ENOG4105W8X HesB YadR YfhF-family protein BTI247_25700 ENOG4105DXD 2-methylcitrate dehydratase BTI247_25710 ENOG4105CR4 methylisocitrate lyase BTI247_25720 ENOG4105C1G acyl-Coa dehydrogenase BTI247_25730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BTI247_25750 ENOG4105N14 lysine exporter protein LysE YggA BTI247_25760 ENOG4105E39 Enoyl-CoA hydratase BTI247_25780 ENOG410836F Transposase BTI247_25800 ENOG4107RFY SbcCD D subunit BTI247_25810 ENOG4105EYH Exonuclease BTI247_25820 ENOG4105DQ6 Transposase BTI247_25870 ENOG4105FCD Major Facilitator BTI247_25880 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BTI247_25890 ENOG4105E4F Isochorismate synthase BTI247_25900 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BTI247_25910 ENOG4105WQI isochorismatase BTI247_25920 ENOG4105CEY Amp-dependent synthetase and ligase BTI247_25930 ENOG4105WQT MbtH domain protein BTI247_25940 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTI247_25970 ENOG4105K70 DNA-binding protein BTI247_26010 ENOG4105BZG amino acid carrier protein BTI247_26060 ENOG4105FE9 pseudouridine synthase BTI247_26070 ENOG4105C22 threonyL-tRNA synthetase BTI247_26080 ENOG4105C19 ABC transporter BTI247_26100 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BTI247_26170 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BTI247_26210 ENOG41081I9 integral membrane protein BTI247_26230 ENOG4108Y4K DNA-binding transcriptional activator BTI247_26260 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BTI247_26280 ENOG4105EYF MMPL domain protein BTI247_26330 ENOG4105WCN acetyltransferase BTI247_26380 ENOG4105C1Q protoporphyrinogen oxidase BTI247_26400 ENOG41068WN BTI247_26460 ENOG4107V2S Transcriptional regulator BTI247_26470 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BTI247_26500 ENOG4105DND Transcriptional regulator BTI247_26520 ENOG4108RPX mosc domain containing protein BTI247_26550 ENOG4105BZ1 (ABC) transporter BTI247_26560 ENOG4105BZ1 (ABC) transporter BTI247_26640 ENOG4108JCI Transcriptional regulator BTI247_26710 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BTI247_26720 ENOG4108KPJ rna polymerase sigma factor BTI247_26770 ENOG4105F32 YngK protein BTI247_26810 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BTI247_26860 ENOG4105DQ6 Transposase BTI247_26890 ENOG4105BZU Histidine kinase BTI247_26910 ENOG4107S9D Alpha beta hydrolase BTI247_27020 ENOG4105DQ6 Transposase BTI247_27060 ENOG4107RVG penicillin-binding protein BTI247_27090 ENOG4107RF6 penicillin-binding protein BTI247_27100 ENOG4107RF6 penicillin-binding protein BTI247_27130 ENOG4105DIN metallophosphoesterase BTI247_27150 ENOG4105CJ1 ABC, transporter BTI247_27170 ENOG4107Z3H Transcriptional regulator, TetR family BTI247_27200 ENOG4105C1G acyl-Coa dehydrogenase BTI247_27210 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BTI247_27220 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BTI247_27230 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BTI247_27240 ENOG4105E39 Enoyl-CoA hydratase BTI247_27250 ENOG4107QX3 carboxylase BTI247_27260 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BTI247_27300 ENOG4105DBI uridine monophosphokinase BTI247_27330 ENOG4105DZ1 carboxypeptidase BTI247_27360 ENOG4105T9C HD domain BTI247_27390 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BTI247_27430 ENOG41075H3 AraC family transcriptional regulator BTI247_27470 ENOG410836F Transposase BTI247_27590 ENOG4105CHR reductase BTI247_27600 ENOG4105KVH Transcriptional regulator BTI247_27610 ENOG41089UC methyltransferase, type 11 BTI247_27630 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BTI247_27760 ENOG4105CPQ Dehydrogenase BTI247_27780 ENOG410900G Protein of unknown function (DUF421) BTI247_27810 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BTI247_27830 ENOG4105DK7 lysyl-tRNA synthetase BTI247_27970 ENOG4105D6E homoserine dehydrogenase BTI247_27990 ENOG4105CPF Cell wall formation (By similarity) BTI247_28000 ENOG4105ETU transcriptional activator (TenA BTI247_28050 ENOG4105VTR Integrase BTI247_28330 ENOG410836F Transposase BTI247_28350 ENOG410836F Transposase BTI247_28370 ENOG410836F Transposase BTI247_28560 ENOG410836F Transposase BTI247_28720 ENOG410667J hydrolase BTI247_28730 ENOG4105BZU Histidine kinase BTI247_28740 ENOG4107RF6 penicillin-binding protein BTI247_28800 ENOG4108JJB ABC transporter BTI247_28830 ENOG4108HGU Histidine kinase BTI247_28970 ENOG4105DY8 decarboxylase BTI247_29000 ENOG4107WD8 ABC transporter, permease BTI247_29040 ENOG4105BZU Histidine kinase BTI247_29050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_29060 ENOG4105U0R haloacid dehalogenase-like hydrolase BTI247_29110 ENOG4107VFR oxidoreductase BTI247_29130 ENOG410836F Transposase BTI247_29200 ENOG4105PKS Excinuclease abc c subunit domain protein BTI247_29300 ENOG4105KWG Pfam:DUF1696 BTI247_29340 ENOG4108XI2 Domain of unknown function (DUF1963) BTI247_29380 ENOG4105E09 nadh pyrophosphatase BTI247_29400 ENOG4105FCD Major Facilitator BTI247_29410 ENOG410836F Transposase BTI247_29500 ENOG4107Y9U Membrane BTI247_29550 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BTI247_29600 ENOG4108Z5V transcriptional regulator, merr family BTI247_29610 ENOG4107Y80 Major Facilitator superfamily BTI247_29650 ENOG4105DQ6 Transposase BTI247_29770 ENOG4105CJN penicillin-binding protein BTI247_29780 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BTI247_29790 ENOG4105CB2 alcohol dehydrogenase BTI247_29870 ENOG4108IUM Glycogen debranching enzyme BTI247_29890 ENOG4105CGH 5'-nucleotidase BTI247_29920 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BTI247_29930 ENOG4105FDR Membrane BTI247_29970 ENOG4105D13 transposase BTI247_30000 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BTI247_30090 ENOG4105MSI germination protein ypeb BTI247_30150 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BTI247_30160 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BTI247_30170 ENOG4107Z3H Transcriptional regulator, TetR family BTI247_30220 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BTI247_30250 ENOG4105E98 transcriptional regulator DeoR family BTI247_30280 ENOG41062ES Transcriptional regulator BTI247_30320 ENOG4107QKR Dehydrogenase BTI247_30340 ENOG4107RUY (E1 component), alpha subunit BTI247_30370 ENOG4105E1F short-chain dehydrogenase reductase BTI247_30380 ENOG4105RHY Pfam:UPF0157 BTI247_30450 ENOG4107SQ8 Glycine betaine BTI247_30460 ENOG4108IJ7 Glycine betaine BTI247_30510 ENOG4105E66 phosphoriboisomerase A BTI247_30520 ENOG41082BV acetyltransferase BTI247_30530 ENOG4105CYP glycoside hydrolase, family BTI247_30540 ENOG4108M1A Chitin-binding protein BTI247_30600 ENOG4105MSB protein, conserved in bacteria BTI247_30650 ENOG4108Z7F N-acetyltransferase BTI247_30710 ENOG4105DQ6 Transposase BTI247_30720 ENOG4105EEM helicase BTI247_30760 ENOG4105C9U ATP-dependent DNA helicase RecQ BTI247_30870 ENOG4108M1A Chitin-binding protein BTI247_30910 ENOG4105BZG amino acid carrier protein BTI247_30920 ENOG4105C26 Dehydrogenase BTI247_30930 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BTI247_30940 ENOG4105CTU Proline racemase BTI247_30950 ENOG4105CTU Proline racemase BTI247_30960 ENOG41080HI glycine oxidase BTI247_31050 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BTI247_31060 ENOG4105DCI Phosphohydrolase BTI247_31070 ENOG4107T5V SNARE associated Golgi BTI247_31090 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BTI247_31130 ENOG4105DTQ mandelate racemase muconate lactonizing BTI247_31160 ENOG4107SET aldo keto reductase BTI247_31220 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BTI247_31230 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTI247_31240 ENOG4105BZU Histidine kinase BTI247_31250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_31280 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BTI247_31320 ENOG4105DPN Oligoendopeptidase f BTI247_31330 ENOG4105EPR degv family BTI247_31450 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BTI247_31460 ENOG4106K7D Major facilitator family transporter BTI247_31510 ENOG4107BMA Transglycosylase associated protein BTI247_31540 ENOG41089UC methyltransferase, type 11 BTI247_31630 ENOG4105CHM Aminotransferase BTI247_31660 ENOG4108ZMI UPF0477 protein BTI247_31720 ENOG4105C02 permease BTI247_31740 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BTI247_31750 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BTI247_31760 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BTI247_31770 ENOG4105D7T ABC transporter BTI247_31850 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BTI247_31930 ENOG4107VC0 DNA alkylation repair enzyme BTI247_31940 ENOG4105C6T cysteine synthase BTI247_31950 ENOG4105C6T cysteine synthase BTI247_31960 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BTI247_31980 ENOG4107VMI polysaccharide deacetylase BTI247_32000 ENOG4108ZCF integral membrane protein BTI247_32010 ENOG4105E0M Sulfatase BTI247_32020 ENOG4105C5H ABC transporter BTI247_32030 ENOG4105EYF MMPL domain protein BTI247_32040 ENOG41082JN Transcriptional regulator BTI247_32050 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BTI247_32100 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BTI247_32120 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BTI247_32240 ENOG41069ER domain protein BTI247_32270 ENOG4105DNP FAD linked oxidase domain protein BTI247_32290 ENOG4105JVQ RNA Polymerase BTI247_32330 ENOG4105D4B ABC, transporter BTI247_32340 ENOG4105F5R ABC transporter BTI247_32350 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BTI247_32370 ENOG4105DKT Transcriptional regulator BTI247_32380 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BTI247_32400 ENOG41061GT Aldolase BTI247_32430 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BTI247_32460 ENOG4105YVS arsR family transcriptional regulator BTI247_32510 ENOG4105II7 pyrroline-5-carboxylate reductase BTI247_32530 ENOG4107258 Transcriptional regulator BTI247_32570 ENOG4105ECK Fatty Acid Desaturase BTI247_32590 ENOG4107RBI VanW family BTI247_32600 ENOG4105G6Z alkaline phosphatase BTI247_32620 ENOG4105VMP Transcriptional regulator BTI247_32670 ENOG41068WN BTI247_32720 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BTI247_32760 ENOG4105C8Y Acetylornithine aminotransferase BTI247_32840 ENOG4108TVJ Nitroreductase BTI247_32850 ENOG4105FS7 Transcriptional regulator BTI247_32880 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BTI247_32940 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BTI247_32960 ENOG4105CMR udp-glucose 4-epimerase BTI247_33000 ENOG4108DMH HTH_ARAC BTI247_33010 ENOG4108XET gCN5-related N-acetyltransferase BTI247_33040 ENOG4108PCN EamA-like transporter family BTI247_33170 ENOG410635A Membrane BTI247_33200 ENOG4108IQI permease BTI247_33220 ENOG4105F1N DNA alkylation repair BTI247_33240 ENOG4105BZU Histidine kinase BTI247_33250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_33270 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BTI247_33340 ENOG4107RF6 penicillin-binding protein BTI247_33350 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BTI247_33360 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BTI247_33390 ENOG4105E7W lamb ycsf family protein BTI247_33410 ENOG4105P4J Allophanate hydrolase, subunit 1 BTI247_33420 ENOG4107258 Transcriptional regulator BTI247_33450 ENOG4106N3A copper homeostasis protein cutc BTI247_33460 ENOG4108ZHR arsR family transcriptional regulator BTI247_33480 ENOG4105FDT acyl-CoA dehydrogenase BTI247_33520 ENOG4105DWD nucleoside recognition domain protein BTI247_33640 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BTI247_33690 ENOG4105E2A Dehydrogenase BTI247_33710 ENOG4105CN5 Metallo-Beta-Lactamase BTI247_33730 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BTI247_33760 ENOG4105CGH 5'-nucleotidase BTI247_33780 ENOG4105CHJ isochorismatase hydrolase BTI247_33830 ENOG41090MY MarR family Transcriptional regulator BTI247_33920 ENOG4105E1K spore germination protein BTI247_33950 ENOG4108606 TspO/MBR family BTI247_33960 ENOG4105CVP deoxyribo-dipyrimidine photolyase BTI247_33990 ENOG4108TWJ NADH dehydrogenase subunit 5 BTI247_34000 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BTI247_34010 ENOG4107VMI polysaccharide deacetylase BTI247_34020 ENOG4105KY5 gCN5-related N-acetyltransferase BTI247_34030 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BTI247_34050 ENOG4105D6J arsenicaL-resistance protein BTI247_34060 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BTI247_34070 ENOG41085FC arsR family transcriptional regulator BTI247_34100 ENOG4105DQ6 Transposase BTI247_34110 ENOG4107P5I polyketide synthase BTI247_34120 ENOG4108IG5 Transcriptional regulator BTI247_34140 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BTI247_34190 ENOG4105CHR reductase BTI247_34200 ENOG4108YXU transcriptional regulator AsnC family BTI247_34300 ENOG4105C37 (CBS) domain BTI247_34370 ENOG4105C44 Serine transporter BTI247_34380 ENOG4105DUM transcriptional regulator, lysR family BTI247_34390 ENOG4105DWP Membrane BTI247_34400 ENOG4105N0V mono-oxygenase ydhR BTI247_34470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_34480 ENOG41062D9 Histidine kinase BTI247_34570 ENOG4105C19 ABC transporter BTI247_34630 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BTI247_34640 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTI247_34680 ENOG410836F Transposase BTI247_34710 ENOG4105K6H D-cysteine desulfhydrase BTI247_34730 ENOG4105E0Y RtcB Protein BTI247_34750 ENOG4105JQZ Methyltransferase BTI247_34790 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BTI247_34830 ENOG4105BZU Histidine kinase BTI247_34850 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BTI247_34880 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BTI247_34920 ENOG4108JQ1 Dehydrogenase BTI247_34930 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BTI247_34960 ENOG41082W1 Cupin 2, conserved barrel domain protein BTI247_34970 ENOG410874W AraC family transcriptional regulator BTI247_35010 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTI247_35050 ENOG4108VXD carboxy-peptidase BTI247_35060 ENOG4105PNM synthesis protein BTI247_35080 ENOG4108ISG Major Facilitator BTI247_35110 ENOG4107MII Sugar-specific transcriptional regulator TrmB BTI247_35120 ENOG4105CZM Major Facilitator BTI247_35150 ENOG4105DA5 (ABC) transporter BTI247_35160 ENOG41069JR BTI247_35210 ENOG4105CRW Short chain fatty acid transporter BTI247_35230 ENOG4105DYS nad(p)h dehydrogenase (quinone) BTI247_35350 ENOG4108K8S endonuclease I BTI247_35370 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BTI247_35420 ENOG4108Z66 YbaK ebsC protein BTI247_35460 ENOG4105KVH Transcriptional regulator BTI247_35470 ENOG4108RCM Nitroreductase BTI247_35540 ENOG4108PSK reductase BTI247_35680 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BTI247_35690 ENOG4105DKQ ROK family BTI247_35710 ENOG4108UW5 maltose o-acetyltransferase BTI247_35720 ENOG4105C31 Tryptophanyl-tRNA synthetase BTI247_35740 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BTI247_35800 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BTI247_35820 ENOG4105EV4 Multidrug resistance protein mdtH BTI247_35870 ENOG4105C37 (CBS) domain BTI247_35900 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BTI247_35910 ENOG4105FAW cDP-glucose 4,6-dehydratase BTI247_35980 ENOG4105DDN Pentapeptide repeat-containing protein BTI247_35990 ENOG4105XDF Protein of unknown function (DUF1272) BTI247_36000 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BTI247_36010 ENOG4105CMG Carbohydrate kinase BTI247_36020 ENOG4105C6Z Gluconate BTI247_36050 ENOG4105CV1 Transketolase (EC 2.2.1.1) BTI247_36060 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BTI247_36070 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BTI247_36080 ENOG4105CIS alcohol dehydrogenase BTI247_36090 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BTI247_36110 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BTI247_36140 ENOG4105C8Q Methyl-accepting chemotaxis BTI247_36150 ENOG4108UX3 '-nucleotidase BTI247_36160 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BTI247_36170 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BTI247_36180 ENOG4105KVH Transcriptional regulator BTI247_36210 ENOG4105CV8 reductase BTI247_36220 ENOG4105F27 Major Facilitator BTI247_36240 ENOG41090KN UPF0303 protein BTI247_36270 ENOG4105C44 Serine transporter BTI247_36340 ENOG4105KVH Transcriptional regulator BTI247_36350 ENOG4108TZY GntR Family Transcriptional Regulator BTI247_36360 ENOG4105D9R oxidoreductase BTI247_36370 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BTI247_36380 ENOG4105KVH Transcriptional regulator BTI247_36390 ENOG4105KVH Transcriptional regulator BTI247_36450 ENOG410836F Transposase BTI247_36490 ENOG4105JAB phenazine biosynthesis protein, phzf family BTI247_36520 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BTI247_36530 ENOG4105KVH Transcriptional regulator BTI247_36560 ENOG4108ZJ4 polysaccharide deacetylase BTI247_36700 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BTI247_36740 ENOG4107YXZ hydrolase, family 25 BTI247_36800 ENOG4105H3G oxidoreductase BTI247_36940 ENOG4108TN2 lmbE family BTI247_36960 ENOG4107R3E Citrate transporter BTI247_36990 ENOG4108MES Periplasmic binding protein BTI247_37000 ENOG4105EHG Permease protein BTI247_37010 ENOG4105DQ5 transport system permease protein BTI247_37020 ENOG4105NX3 Membrane BTI247_37050 ENOG4105NX3 Membrane BTI247_37090 ENOG4107CUJ Protein of unknown function (DUF2690) BTI247_37110 ENOG4107V2S Transcriptional regulator BTI247_37150 ENOG4105C98 muts2 protein BTI247_37170 ENOG4105DQ6 Transposase BTI247_37180 ENOG4105C98 muts2 protein BTI247_37200 ENOG4105E5K Alpha-amylase BTI247_37210 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BTI247_37220 ENOG4105DPN Oligoendopeptidase f BTI247_37260 ENOG4105FFC UPF0187 protein BTI247_37290 ENOG4108A04 Beta-lactamase BTI247_37340 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BTI247_37360 ENOG4105EEM helicase BTI247_37430 ENOG41082BM Transcriptional regulator, arsr family BTI247_37440 ENOG4105CIS alcohol dehydrogenase BTI247_37450 ENOG4105CNG UPF0061 protein BTI247_37520 ENOG4105CQB FAD linked oxidase domain protein BTI247_37570 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BTI247_37580 ENOG4108M1A Chitin-binding protein BTI247_37620 ENOG4105E1K spore germination protein BTI247_37700 ENOG410836F Transposase BTI247_37740 ENOG4105BZU Histidine kinase BTI247_37750 ENOG4105DQ6 Transposase BTI247_37770 ENOG4105BZU Histidine kinase BTI247_37790 ENOG41067SE Tetr family transcriptional regulator BTI247_37800 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BTI247_37840 ENOG4108VXD carboxy-peptidase BTI247_37850 ENOG4107DUR UPF0457 protein BTI247_37890 ENOG4105BZU Histidine kinase BTI247_37910 ENOG4105KT7 mgtC SapB transporter BTI247_37930 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BTI247_37950 ENOG41073R8 VanW family BTI247_37970 ENOG4108R1P BTI247_38020 ENOG4105VEQ Cold shock protein BTI247_38060 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BTI247_38100 ENOG410904N short-chain dehydrogenase reductase BTI247_38120 ENOG4106IQC argininosuccinate lyase BTI247_38150 ENOG4108IA2 Sodium pantothenate symporter BTI247_38170 ENOG4105C26 Dehydrogenase BTI247_38180 ENOG4105CHR reductase BTI247_38200 ENOG4105EWU Squalene--hopene cyclase BTI247_38220 ENOG4105FR1 rard protein BTI247_38230 ENOG410696E Membrane BTI247_38260 ENOG4105D1F ATP-binding protein BTI247_38280 ENOG4108ZAF Molybdopterin BTI247_38290 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTI247_38300 ENOG4105D06 uba thif-type nad fad binding protein BTI247_38310 ENOG4105TMB Formate nitrite transporter BTI247_38330 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BTI247_38340 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BTI247_38360 ENOG4108JB9 formate dehydrogenase BTI247_38370 ENOG4105E1K spore germination protein BTI247_38400 ENOG4105CUB amino acid BTI247_38410 ENOG4105CUB amino acid BTI247_38520 ENOG4108KGH TRANSCRIPTIONal BTI247_38540 ENOG4105EMN RNA polymerase sigma factor BTI247_38560 ENOG4105CIG ABC transporter BTI247_38620 ENOG4105D9R oxidoreductase BTI247_38640 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTI247_38650 ENOG4105K4P CoA-binding domain protein BTI247_38660 ENOG4105C0H protease BTI247_38670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_38690 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BTI247_38700 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BTI247_38710 ENOG4105W8X HesB YadR YfhF-family protein BTI247_38760 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BTI247_38770 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTI247_38790 ENOG4108JJA ABC, transporter BTI247_38800 ENOG4108I0Z Aconitate hydratase BTI247_38860 ENOG4105E5W Transporter BTI247_38880 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTI247_38920 ENOG4107F3J Amp-dependent synthetase and ligase BTI247_38930 ENOG4107ZYJ bioY protein BTI247_38940 ENOG4105CEY Amp-dependent synthetase and ligase BTI247_38950 ENOG4108IMY Transcriptional regulator BTI247_39020 ENOG4107AYK membrAne BTI247_39040 ENOG4105BZU Histidine kinase BTI247_39050 ENOG4105FBA Phospholipase Carboxylesterase BTI247_39060 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BTI247_39070 ENOG4105CK7 Sodium proline symporter BTI247_39090 ENOG4105CBC glutamate synthase BTI247_39100 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BTI247_39110 ENOG4108VJ1 Transcriptional regulator (CarD family BTI247_39120 ENOG4108903 Formimidoylglutamase BTI247_39170 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BTI247_39230 ENOG4107QIV Cytochrome c biogenesis protein BTI247_39250 ENOG4105CH2 amidohydrolase BTI247_39270 ENOG4105CJ1 ABC, transporter BTI247_39280 ENOG4105CJ1 ABC, transporter BTI247_39320 ENOG4107RSM transcriptional regulator BTI247_39330 ENOG4105VAW lrga family BTI247_39340 ENOG41067MG lrgb family BTI247_39390 ENOG410836F Transposase BTI247_39430 ENOG4105BZ1 (ABC) transporter BTI247_39440 ENOG4105BZ1 (ABC) transporter BTI247_39510 ENOG4108HW3 (ABC) transporter BTI247_39520 ENOG4105CGH 5'-nucleotidase BTI247_39540 ENOG4108SVB resolvase BTI247_39580 ENOG4105K7K Transcriptional regulator BTI247_39590 ENOG4105C5F glutamine synthetase BTI247_39600 ENOG4105KV4 Transcriptional regulator BTI247_39610 ENOG4105CXI aluminum resistance protein BTI247_39620 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BTI247_39630 ENOG4105EN6 Membrane BTI247_39650 ENOG4106F1P AAA ATPase, central domain protein BTI247_39720 ENOG41069ER domain protein BTI247_39730 ENOG4105DM4 PTS System BTI247_39740 ENOG4105DE4 1-phosphofructokinase BTI247_39750 ENOG4105E98 transcriptional regulator DeoR family BTI247_39760 ENOG4107QW4 alcohol dehydrogenase BTI247_39770 ENOG4108SJC Membrane BTI247_39800 ENOG4105C85 amino acid BTI247_39830 ENOG4105TMB Formate nitrite transporter BTI247_39840 ENOG4105K70 DNA-binding protein BTI247_39860 ENOG4105C59 p-type ATPase BTI247_39870 ENOG410681U heavy metal transport detoxification protein BTI247_39880 ENOG4105VPX protein, conserved in bacteria BTI247_39920 ENOG4105NIV Esterase BTI247_39930 ENOG4105E0A ABC, transporter BTI247_39970 ENOG4105CGK Exodeoxyribonuclease III BTI247_39990 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BTI247_40000 ENOG4105D03 DNA-3-methyladenine glycosylase II BTI247_40060 ENOG4105BZU Histidine kinase BTI247_40130 ENOG41067MG lrgb family BTI247_40160 ENOG4105DQ6 Transposase BTI247_40190 ENOG4108S3Y transcriptional regulator BTI247_40200 ENOG4105CS2 ec 3.2.1.21 BTI247_40230 ENOG4105F0V Cell wall hydrolase BTI247_40250 ENOG4105E0M Sulfatase BTI247_40260 ENOG410890F Dynamin family BTI247_40350 ENOG4105DQU oxidoreductase, subunit beta BTI247_40360 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BTI247_40370 ENOG4108IGT Dipeptidase BTI247_40380 ENOG4105MCT stage V sporulation protein S BTI247_40390 ENOG4105D48 metallophosphoesterase BTI247_40440 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BTI247_40470 ENOG4105XZV Protein of unknown function (DUF3243) BTI247_40480 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BTI247_40520 ENOG4105UIB (ABC) transporter BTI247_40530 ENOG4108JQ9 ABC transporter BTI247_40540 ENOG4105DIH basic membrane BTI247_40550 ENOG4105FDP GntR family transcriptional regulator BTI247_40570 ENOG4105CNU cell division protein FtsK BTI247_40590 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BTI247_40610 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BTI247_40630 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BTI247_40640 ENOG4108S0H Dipicolinic acid synthetase, b subunit BTI247_40650 ENOG4105E35 Dipicolinate synthase subunit A BTI247_40670 ENOG4105C1V Peptidase, M16 BTI247_40710 ENOG4105DTN riboflavin biosynthesis protein ribF BTI247_40740 ENOG4105W7A Protein of unknown function (DUF503) BTI247_40760 ENOG4105VHM ribosomal protein BTI247_40770 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BTI247_40780 ENOG4105CHV Transcription elongation factor NusA BTI247_40800 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BTI247_40820 ENOG4105DZP Membrane-associated zinc metalloprotease BTI247_40830 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BTI247_40840 ENOG4105KNE Phosphatidate cytidylyltransferase BTI247_40850 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BTI247_40870 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BTI247_40930 ENOG4108HE4 integrase family BTI247_40950 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BTI247_40960 ENOG4105C79 DNA protecting protein DprA BTI247_40970 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BTI247_41000 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BTI247_41050 ENOG4105VB6 UPF0109 protein BTI247_41090 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BTI247_41100 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BTI247_41130 ENOG4105CHR reductase BTI247_41140 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BTI247_41170 ENOG4105CB5 ATP-dependent DNA helicase recG BTI247_41180 ENOG4105DP4 dak2 domain fusion protein ylov BTI247_41190 ENOG4108ZAA Alkaline-shock protein BTI247_41210 ENOG4105FJ0 thiamine BTI247_41220 ENOG4105DJV ribulose-phosphate 3-epimerase BTI247_41230 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BTI247_41240 ENOG4105D9P serine threonine protein kinase BTI247_41250 ENOG4108ZF3 Phosphatase BTI247_41270 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BTI247_41300 ENOG4105C25 Primosomal protein n' BTI247_41310 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BTI247_41350 ENOG4105DSJ YicC domain protein BTI247_41370 ENOG4105F23 Fibronectin-binding protein BTI247_41390 ENOG4105DC7 peptidase M24 BTI247_41490 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BTI247_41560 ENOG4105C34 Pseudouridine synthase BTI247_41590 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BTI247_41620 ENOG4105DBK s4 domain protein BTI247_41630 ENOG41067XK integral membrane protein BTI247_41650 ENOG4105DFA alanine racemase domain protein BTI247_41660 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BTI247_41670 ENOG4105WR5 sporulation protein, YlmC YmxH family BTI247_41690 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTI247_41710 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BTI247_41720 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BTI247_41740 ENOG4105D4A Cell wall formation (By similarity) BTI247_41750 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BTI247_41760 ENOG4105CNI cell division protein FtsW BTI247_41790 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BTI247_41800 ENOG4105CJN penicillin-binding protein BTI247_41810 ENOG4105CJN penicillin-binding protein BTI247_41840 ENOG41074B2 UPF0747 protein BTI247_41890 ENOG4105KNH Nucleic acid-binding protein BTI247_41910 ENOG41063PX domain protein BTI247_41920 ENOG4105D78 K07001 NTE family protein BTI247_41930 ENOG4105H20 Sporulation integral membrane protein YlbJ BTI247_41950 ENOG4106H78 methyltransferase BTI247_42000 ENOG4107TB6 phosphoglycerate mutase BTI247_42030 ENOG4106UY4 Inherit from COG: Scp-like extracellular BTI247_42130 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BTI247_42140 ENOG4105CNI cell division protein FtsW BTI247_42170 ENOG4108IAB Phoh family BTI247_42210 ENOG4105QA2 BTI247_42220 ENOG4105CI3 gtp-binding protein typa BTI247_42240 ENOG4105ECY inositol monophosphatase BTI247_42280 ENOG4105CXN decarboxylase BTI247_42380 ENOG4105CPP Dehydrogenase, E1 component BTI247_42410 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BTI247_42420 ENOG4108X4Q Hydrolase BTI247_42440 ENOG4105CN5 Metallo-Beta-Lactamase BTI247_42450 ENOG4107ZYR domain protein BTI247_42520 ENOG4108XRC Protein of unknown function (DUF458) BTI247_42540 ENOG4107IN1 Protein of unknown function (DUF1797) BTI247_42570 ENOG4105EPM Diguanylate phosphodiesterase BTI247_42580 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BTI247_42610 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BTI247_42630 ENOG4105UIN BTI247_42710 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BTI247_42750 ENOG4108HGU Histidine kinase BTI247_42770 ENOG4105CHM Aminotransferase BTI247_42780 ENOG4105FKQ transcriptional regulator BTI247_42790 ENOG4105EG2 ABC transporter, permease BTI247_42810 ENOG4107FKK extracellular solute-binding protein family 1 BTI247_42830 ENOG4105CG3 alpha amylase, catalytic region BTI247_42920 ENOG4105CHU acetyl-coa acetyltransferase BTI247_42980 ENOG4105K7K Transcriptional regulator BTI247_42990 ENOG4105DTD Dehydrogenase BTI247_43030 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BTI247_43080 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BTI247_43110 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BTI247_43130 ENOG4105BZU Histidine kinase BTI247_43170 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BTI247_43200 ENOG4105CID antiterminator BTI247_43220 ENOG4105FDP GntR family transcriptional regulator BTI247_43240 ENOG4105CE4 GlcNAc 6-P deacetylase BTI247_43310 ENOG4107ZE5 PPIases accelerate the folding of proteins BTI247_43320 ENOG4105PTM secreted protein BTI247_43330 ENOG4105J7I hydrolase BTI247_43350 ENOG4105G6R Stage v sporulation protein ae BTI247_43370 ENOG4105CZ3 stage V sporulation protein ad BTI247_43380 ENOG41090VF Stage v sporulation protein ac BTI247_43420 ENOG4105C8J )-transporter BTI247_43430 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTI247_43450 ENOG41082AN stage II sporulation protein BTI247_43460 ENOG4105DZ1 carboxypeptidase BTI247_43470 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BTI247_43480 ENOG4105DVE abc transporter atp-binding protein BTI247_43550 ENOG4105D7N magnesium and cobalt transport protein CorA BTI247_43620 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTI247_43640 ENOG4105I3K Ferric uptake regulator, Fur family BTI247_43650 ENOG4105MZ9 stage II sporulation protein m BTI247_43690 ENOG4105CPC Aldo Keto reductase BTI247_43710 ENOG4105RHY Pfam:UPF0157 BTI247_43750 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BTI247_43770 ENOG4105ETE Transcriptional regulator (LacI family BTI247_43780 ENOG4108YM7 Gcn5-related n-acetyltransferase BTI247_43830 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BTI247_43840 ENOG4108R6K riboflavin synthase, subunit alpha BTI247_43890 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTI247_43900 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTI247_43930 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTI247_43960 ENOG4105DFD Na H antiporter BTI247_43970 ENOG4105CGH 5'-nucleotidase BTI247_44020 ENOG4105DBV ornithine carbamoyltransferase BTI247_44050 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BTI247_44080 ENOG4108IXY short-chain dehydrogenase reductase BTI247_44090 ENOG41069FQ Metallo-beta-lactamase superfamily BTI247_44100 ENOG4105II7 pyrroline-5-carboxylate reductase BTI247_44110 ENOG4105EJQ L-serine dehydratase BTI247_44170 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BTI247_44200 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BTI247_44210 ENOG4105D9U N-acetyltransferase BTI247_44230 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BTI247_44240 ENOG4108QEG Membrane BTI247_44250 ENOG4105CDA abc transporter atp-binding protein BTI247_44260 ENOG4105E5Q amino acid AbC transporter BTI247_44270 ENOG4108HW3 (ABC) transporter BTI247_44290 ENOG4105G7B Protein of unknown function (DUF2992) BTI247_44310 ENOG4108QY0 Membrane BTI247_44330 ENOG4105C7S Dehydrogenase BTI247_44340 ENOG4105CPP Dehydrogenase, E1 component BTI247_44370 ENOG4105CKM Branched-chain carboxylic acid kinase BTI247_44380 ENOG4107RDP Dehydrogenase BTI247_44400 ENOG4108JUB Transcriptional regulator BTI247_44420 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BTI247_44450 ENOG4107QQR Sporulation BTI247_44460 ENOG4105S1Z Stage IV sporulation protein B BTI247_44470 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BTI247_44480 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BTI247_44490 ENOG4105DX0 Hemolysin A BTI247_44510 ENOG4105CTB Polyprenyl synthetase BTI247_44540 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BTI247_44560 ENOG4108ZSR alkaline shock protein BTI247_44570 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BTI247_44620 ENOG410644B Stage III sporulation protein af BTI247_44640 ENOG4105KQ4 Stage iii sporulation protein ad BTI247_44650 ENOG4108CQH stage III sporulation protein AC BTI247_44660 ENOG4105KR5 Stage iii sporulation protein BTI247_44670 ENOG4105CD2 stage iii sporulation protein aa BTI247_44720 ENOG4105DC7 peptidase M24 BTI247_44730 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BTI247_44750 ENOG4105CBJ Metal-dependent enzyme BTI247_44770 ENOG4107YBY Hydrolase BTI247_44830 ENOG41082GG biotin lipoate A B protein ligase BTI247_44840 ENOG4105WZW rhodanese family BTI247_44890 ENOG41080TC multidrug resistance protein BTI247_44950 ENOG4105CJ1 ABC, transporter BTI247_44960 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BTI247_45020 ENOG4105C0D helicase BTI247_45190 ENOG4107R6U sodium dicarboxylate symporter BTI247_45270 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BTI247_45280 ENOG4105C3R Methionine synthase BTI247_45300 ENOG4105C28 cystathionine BTI247_45310 ENOG4105C28 cystathionine BTI247_45350 ENOG4105C5X domain protein BTI247_45370 ENOG4105DKQ ROK family BTI247_45390 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BTI247_45430 ENOG4108UTW Plays a role in the regulation of phosphate uptake BTI247_45460 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BTI247_45470 ENOG4105C8U phosphate abc transporter BTI247_45480 ENOG4105C8U phosphate abc transporter BTI247_45490 ENOG4105EXS phosphate abc transporter BTI247_45500 ENOG4107RF6 penicillin-binding protein BTI247_45520 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTI247_45570 ENOG4105N80 Ferric uptake regulator, Fur family BTI247_45590 ENOG4105FDK ABC transporter BTI247_45600 ENOG4108JYZ YitT family BTI247_45610 ENOG41069ZM Protein of unknown function (DUF2624) BTI247_45660 ENOG4105EGD dinuclear metal center protein, YbgI family BTI247_45690 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTI247_45700 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BTI247_45750 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BTI247_45760 ENOG4105KG3 cytidine deaminase BTI247_45770 ENOG4107YR5 Diacylglycerol kinase BTI247_45780 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BTI247_45790 ENOG4105CTJ Metal Dependent Phosphohydrolase BTI247_45800 ENOG4105C9A Phoh family BTI247_45820 ENOG41068P3 sporulation protein YqfC BTI247_45840 ENOG4105KTH gatB Yqey BTI247_45860 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BTI247_45870 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BTI247_45930 ENOG4105CSA Coproporphyrinogen iii oxidase BTI247_45940 ENOG4105KVH Transcriptional regulator BTI247_45990 ENOG4105TQK DNA polymerase iii, delta' subunit BTI247_46010 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BTI247_46020 ENOG4108UK2 deaminase BTI247_46030 ENOG4105KQC Competence protein BTI247_46050 ENOG4105DXX methyltransferase BTI247_46070 ENOG4108WF2 Metal Dependent Phosphohydrolase BTI247_46090 ENOG410812S Rna-binding protein BTI247_46110 ENOG4105CQW ribosome biogenesis GTPase YqeH BTI247_46120 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BTI247_46150 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTI247_46190 ENOG4108TVJ Nitroreductase BTI247_46220 ENOG4105G6Z alkaline phosphatase BTI247_46230 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BTI247_46240 ENOG4108MUZ hydrolase BTI247_46310 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BTI247_46340 ENOG4105MIR Phenylalanine 4-monooxygenase BTI247_46360 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BTI247_46440 ENOG4105S6R Iron-hydroxamate transporter permease subunit BTI247_46450 ENOG4108V5C ABC transporter BTI247_46470 ENOG4108EKI Dehydrogenase BTI247_46480 ENOG4105C28 cystathionine BTI247_46540 ENOG4107XRG penicillin-binding protein BTI247_46550 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BTI247_46570 ENOG4105CFP Peptidase U32 BTI247_46580 ENOG4105XYU peptidase (U32 family) BTI247_46590 ENOG4108VQJ O-methyltransferase BTI247_46600 ENOG4105HHA aminodeoxychorismate lyase BTI247_46640 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTI247_46660 ENOG4105C02 permease BTI247_46690 ENOG41060CR BTI247_46700 ENOG4105C7H Helicase, RecD TraA family BTI247_46720 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BTI247_46730 ENOG4105C3J Cysteine desulfurase BTI247_46750 ENOG4105D1H recombination factor protein RarA BTI247_46760 ENOG4108VCI transcription factor, rsfa family BTI247_46770 ENOG4105CUZ uba thif-type nad fad binding protein BTI247_46790 ENOG4105CUT histidyl-tRNA synthetase BTI247_46830 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BTI247_46840 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BTI247_46860 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BTI247_46870 ENOG41076HS cation diffusion facilitator family transporter BTI247_46880 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BTI247_46900 ENOG4105CKP Polysaccharide Biosynthesis Protein BTI247_46910 ENOG4108QG2 Membrane BTI247_46930 ENOG4105VIE preprotein translocase, subunit YajC BTI247_46960 ENOG41061AI Protein of unknown function (DUF2905) BTI247_46990 ENOG4108HUF Transporter BTI247_47050 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BTI247_47060 ENOG4108IYU L-aspartate oxidase BTI247_47090 ENOG4108RPX mosc domain containing protein BTI247_47100 ENOG4105CQC Prephenate dehydratase BTI247_47130 ENOG4105C19 ABC transporter BTI247_47140 ENOG4105EWM Histidine kinase BTI247_47160 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BTI247_47190 ENOG4105X36 (ribosomal) protein BTI247_47210 ENOG4105C03 ribonuclease BTI247_47240 ENOG4107QMS site-determining protein BTI247_47270 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BTI247_47280 ENOG4105DFF Rod shape-determining protein mreb BTI247_47360 ENOG4105DQ6 Transposase BTI247_47390 ENOG4106E8G BTI247_47460 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BTI247_47490 ENOG4105CHH sulfate transporter BTI247_47600 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BTI247_47610 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BTI247_47640 ENOG41068KH stage VI sporulation protein D BTI247_47660 ENOG4105D52 delta-aminolevulinic acid dehydratase BTI247_47710 ENOG4105K56 Transcriptional regulator BTI247_47750 ENOG4108IUQ atp-dependent protease BTI247_47810 ENOG4108QCI YvbH-like oligomerisation region BTI247_47880 ENOG4105M59 Phosphodiesterase, mj0936 family BTI247_47910 ENOG4108XJQ germination protein BTI247_47930 ENOG4108PCX Major Facilitator BTI247_47950 ENOG4105PFC Transcriptional regulator BTI247_47970 ENOG4105DZC cytosine deaminase BTI247_47980 ENOG41067S9 phage shock protein C, PspC BTI247_47990 ENOG4108JCI Transcriptional regulator BTI247_48010 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BTI247_48020 ENOG4108Z40 Transcriptional regulator BTI247_48030 ENOG4105RHA ABC transporter, permease BTI247_48040 ENOG4108IUX (ABC) transporter BTI247_48050 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BTI247_48060 ENOG4105ER2 Ompa motb domain protein BTI247_48070 ENOG4105E14 MotA TolQ exbB proton channel BTI247_48080 ENOG4108VXD carboxy-peptidase BTI247_48100 ENOG4105E33 succinate dehydrogenase BTI247_48120 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BTI247_48140 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BTI247_48150 ENOG4105K63 Thioredoxin BTI247_48160 ENOG4105C10 Electron transfer flavoprotein BTI247_48170 ENOG4105BZJ Electron transfer flavoprotein BTI247_48180 ENOG41060WC Enoyl-CoA hydratase BTI247_48190 ENOG4107Z3H Transcriptional regulator, TetR family BTI247_48200 ENOG4105CEY Amp-dependent synthetase and ligase BTI247_48220 ENOG4105J76 Periplasmic binding protein BTI247_48230 ENOG4105DQ6 Transposase BTI247_48250 ENOG4105S6R Iron-hydroxamate transporter permease subunit BTI247_48360 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTI247_48390 ENOG4105DR4 Methyltransferase BTI247_48410 ENOG4105KFN sortase, SrtB family BTI247_48420 ENOG4105E0A ABC, transporter BTI247_48450 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BTI247_48470 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BTI247_48490 ENOG4105FE9 pseudouridine synthase BTI247_48510 ENOG4105DCG PHP domain protein BTI247_48540 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BTI247_48570 ENOG4105C5S asparaginyl-tRNA synthetase BTI247_48590 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BTI247_48620 ENOG4108RWN rrna methyltransferase BTI247_48680 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTI247_48690 ENOG4105CW7 secretion protein, HlyD family BTI247_48700 ENOG4108JGH Tetr family transcriptional regulator BTI247_48710 ENOG4105CN9 Peptidase m42 family protein BTI247_48750 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BTI247_48760 ENOG4105C22 threonyL-tRNA synthetase BTI247_48770 ENOG4108TDW sporulation protein YtxC BTI247_48820 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BTI247_48830 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BTI247_48840 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BTI247_48860 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BTI247_48870 ENOG4105C2M dna polymerase I BTI247_48880 ENOG4105BZU Histidine kinase BTI247_48890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTI247_48940 ENOG4108HMX isocitrate dehydrogenase (NADP) BTI247_48950 ENOG4105BZN citrate synthase BTI247_48970 ENOG4108REF Sporulation integral membrane protein ytvi BTI247_48980 ENOG4105FS0 cytoplasmic membrane protein BTI247_49030 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BTI247_49040 ENOG4105C6K Malic enzyme BTI247_49050 ENOG4105C0B DNA polymerase III (alpha subunit) BTI247_49060 ENOG4105VV2 BTI247_49080 ENOG4105SFS phosphoesterase RecJ domain protein BTI247_49140 ENOG4105DC7 peptidase M24 BTI247_49220 ENOG4105Z7P Acetyltransferase (GNAT) family BTI247_49230 ENOG41082W1 Cupin 2, conserved barrel domain protein BTI247_49270 ENOG4107YZX Universal stress protein BTI247_49360 ENOG4108JYZ YitT family BTI247_49400 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BTI247_49420 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BTI247_49430 ENOG4106F1P AAA ATPase, central domain protein BTI247_49450 ENOG4106F1P AAA ATPase, central domain protein BTI247_49460 ENOG4105KBJ sporulation protein ytfj BTI247_49490 ENOG4105EFZ amidohydrolase BTI247_49510 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BTI247_49560 ENOG4105RQF LysR family Transcriptional regulator BTI247_49580 ENOG4105U5Y Transcriptional regulator BTI247_49600 ENOG4105C28 cystathionine BTI247_49680 ENOG4105EMN RNA polymerase sigma factor BTI247_49700 ENOG4108UW5 maltose o-acetyltransferase BTI247_49720 ENOG4105F1V Acetoin utilization protein BTI247_49730 ENOG4105W87 Cbs domain BTI247_49740 ENOG4105DGU Histone deacetylase BTI247_49760 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTI247_49770 ENOG4105BZU Histidine kinase BTI247_49780 ENOG4107SNB ankyrin repeat protein YahD BTI247_49790 ENOG4105EP9 oxidoreductase BTI247_49840 ENOG4105ETE Transcriptional regulator (LacI family BTI247_49850 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BTI247_49890 ENOG4105C88 aminopeptidase BTI247_49980 ENOG4108VDD TRNA binding domain protein BTI247_50040 ENOG4105C8F Beta-lactamase domain protein BTI247_50070 ENOG4108V15 phosphotransferase enzyme family BTI247_50080 ENOG4108IUM Glycogen debranching enzyme BTI247_50100 ENOG4107QSE Dipeptidase BTI247_50110 ENOG4105YW5 deoR family transcriptional regulator BTI247_50140 ENOG4105CBX hi0933 family BTI247_50230 ENOG4108VJ1 Transcriptional regulator (CarD family BTI247_50240 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BTI247_50250 ENOG4105CSC Glucose uptake protein BTI247_50280 ENOG4108ZAF Molybdopterin BTI247_50290 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BTI247_50300 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTI247_50320 ENOG4105D06 uba thif-type nad fad binding protein BTI247_50330 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BTI247_50370 ENOG41085GJ domain protein BTI247_50390 ENOG4105DWV Homoserine O-trans-acetylase BTI247_50410 ENOG4108B31 Spore germination protein BTI247_50460 ENOG4105C8T Leucyl-tRNA synthetase BTI247_50480 ENOG410605W Major Facilitator BTI247_50490 ENOG4107S91 Sodium hydrogen exchanger BTI247_50500 ENOG4105NCW Trka-c domain protein BTI247_50530 ENOG4105C19 ABC transporter BTI247_50570 ENOG4105N5T Radical SAM Protein BTI247_50630 ENOG4105E8V Alpha Beta Hydrolase Fold protein BTI247_50640 ENOG4108Z0R Transferase BTI247_50650 ENOG4105YVM Phosphoesterase, PA-phosphatase related BTI247_50660 ENOG4105BZF Glycosyl transferase (Group 1 BTI247_50680 ENOG4105EPU Molybdenum cofactor synthesis domain protein BTI247_50820 ENOG4105BZU Histidine kinase BTI247_50830 ENOG4105BZU Histidine kinase BTI247_50840 ENOG4105CH6 catalase BTI247_50850 ENOG4107S9D Alpha beta hydrolase BTI247_50860 ENOG4107T7U Sulfatase BTI247_50890 ENOG4105D2X ABC transporter substrate-binding protein BTI247_50910 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BTI247_51040 ENOG4108V2W Carbonate dehydratase BTI247_51050 ENOG4105C4M (Ubiquinol oxidase) subunit I BTI247_51060 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BTI247_51140 ENOG41087YS Phage shock protein A BTI247_51220 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BTI247_51230 ENOG4105BZU Histidine kinase BTI247_51240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_51290 ENOG4108UGV hypoxanthine phosphoribosyltransferase BTI247_51300 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BTI247_51390 ENOG4105C19 ABC transporter BTI247_51420 ENOG4107ZTW SNARE associated Golgi BTI247_51450 ENOG4105C19 ABC transporter BTI247_51460 ENOG41086D8 Transcriptional regulator BTI247_51480 ENOG41082BM Transcriptional regulator, arsr family BTI247_51580 ENOG4105C6Z Gluconate BTI247_51590 ENOG4105FDP GntR family transcriptional regulator BTI247_51630 ENOG41069H0 dihydroorotase EC 3.5.2.3 BTI247_51670 ENOG4105DTQ mandelate racemase muconate lactonizing BTI247_51680 ENOG4105CEY Amp-dependent synthetase and ligase BTI247_51690 ENOG4108IPT Naphthoate synthase BTI247_51700 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BTI247_51710 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BTI247_51720 ENOG4105E4F Isochorismate synthase BTI247_51730 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BTI247_51750 ENOG4105VEQ Cold shock protein BTI247_51840 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BTI247_51850 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BTI247_51870 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BTI247_52160 ENOG4105KT7 mgtC SapB transporter BTI247_52170 ENOG4107PBV potassium channel BTI247_52200 ENOG4105WG9 Conserved Protein BTI247_52220 ENOG4105CHM Aminotransferase BTI247_52230 ENOG4108ZB6 transcriptional regulator AsnC family BTI247_52240 ENOG4105C5I Dehydrogenase BTI247_52250 ENOG4108MUZ hydrolase BTI247_52270 ENOG4105C87 Aminotransferase class I and II BTI247_52300 ENOG4105Y38 Kinase-associated protein B BTI247_52320 ENOG4107R3E Citrate transporter BTI247_52350 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BTI247_52360 ENOG4105KA0 thioesterase Superfamily protein BTI247_52390 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BTI247_52430 ENOG41069ER domain protein BTI247_52460 ENOG4105CEP NADH dehydrogenase BTI247_52520 ENOG4105EWC Purine nucleoside phosphorylase BTI247_52540 ENOG4108VQJ O-methyltransferase BTI247_52580 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BTI247_52620 ENOG4108JJA ABC, transporter BTI247_52630 ENOG4105C4B ABC transporter, permease BTI247_52640 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BTI247_52750 ENOG41083MR nifu domain-containing protein BTI247_52780 ENOG4108W5N phosphatidylglycerophosphatase a BTI247_52820 ENOG4105DAX Pfam:DUF2983 BTI247_52840 ENOG4105DYS nad(p)h dehydrogenase (quinone) BTI247_52850 ENOG4105D4U had-superfamily hydrolase, subfamily iia BTI247_52880 ENOG4105CBT Fructose-1,6-bisphosphatase BTI247_52910 ENOG4105MMD transcriptional regulator BTI247_52920 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BTI247_52930 ENOG4107TXC Transcriptional regulator BTI247_52940 ENOG41090T1 Membrane BTI247_52990 ENOG4105FAA peptidase M23 BTI247_53000 ENOG4108YTE sporulation protein YunB BTI247_53010 ENOG4105KZD Domain of unknown function (DUF1805) BTI247_53020 ENOG4107R8B 5'-nucleotidase BTI247_53030 ENOG4105DIW FeS assembly protein SUFB BTI247_53040 ENOG4108UNV SUF system FeS assembly protein, NifU family BTI247_53050 ENOG4105C9B Cysteine desulfurase BTI247_53060 ENOG4105JRK feS assembly protein SufD BTI247_53070 ENOG4105C3K feS assembly ATPase SufC BTI247_53080 ENOG4105D01 (LipO)protein BTI247_53090 ENOG4105D01 (LipO)protein BTI247_53100 ENOG4108UMI ABC transporter, permease BTI247_53110 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTI247_53150 ENOG410836F Transposase BTI247_53170 ENOG41080E8 Transcriptional regulator, Spx MgsR family BTI247_53210 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BTI247_53260 ENOG4105DQ6 Transposase BTI247_53290 ENOG4108W8B Beta-lactamase domain protein BTI247_53300 ENOG4105C1G acyl-Coa dehydrogenase BTI247_53310 ENOG4105CHU acetyl-coa acetyltransferase BTI247_53340 ENOG4105DZ1 carboxypeptidase BTI247_53380 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTI247_53410 ENOG4108SUT Major Facilitator Superfamily BTI247_53420 ENOG4107R7I amino acid BTI247_53450 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BTI247_53470 ENOG4107AYK membrAne BTI247_53540 ENOG4107ZTW SNARE associated Golgi BTI247_53560 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BTI247_53570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_53580 ENOG4105BZU Histidine kinase BTI247_53600 ENOG4108FPN Integrase BTI247_53630 ENOG4105C8Q Methyl-accepting chemotaxis BTI247_53640 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTI247_53650 ENOG4105VG1 fes assembly suf system protein BTI247_53660 ENOG4105D4Y metalloprotease BTI247_53700 ENOG4107T5V SNARE associated Golgi BTI247_53710 ENOG4107S91 Sodium hydrogen exchanger BTI247_53720 ENOG4105NCW Trka-c domain protein BTI247_53750 ENOG4105DQ6 Transposase BTI247_53770 ENOG410836F Transposase BTI247_53780 ENOG4108RMU ferritin dps family protein BTI247_53810 ENOG4108URH decarboxylase BTI247_53830 ENOG41090A1 ferritin BTI247_53840 ENOG4105DHF Membrane BTI247_53850 ENOG4105D9N nucleoside BTI247_53860 ENOG4105D9N nucleoside BTI247_53900 ENOG4108RYK Nad-dependent epimerase dehydratase BTI247_53930 ENOG4105CV8 reductase BTI247_53940 ENOG4105F27 Major Facilitator BTI247_53950 ENOG4105KVH Transcriptional regulator BTI247_53980 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BTI247_53990 ENOG4105D4A Cell wall formation (By similarity) BTI247_54030 ENOG4105WMR Protein CrcB homolog BTI247_54040 ENOG4105WMR Protein CrcB homolog BTI247_54080 ENOG4105C5H ABC transporter BTI247_54090 ENOG4108MK9 spermidine N(1)-acetyltransferase BTI247_54100 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BTI247_54120 ENOG4108W2Y isochorismatase BTI247_54180 ENOG4108IPW abc transporter atp-binding protein BTI247_54190 ENOG4105CM4 permease protein BTI247_54250 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BTI247_54270 ENOG4105XZU Preprotein translocase, subunit SecG BTI247_54280 ENOG41067MG lrgb family BTI247_54380 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTI247_54420 ENOG41090VF Stage v sporulation protein ac BTI247_54430 ENOG4105CZ3 stage V sporulation protein ad BTI247_54460 ENOG4108QY0 Membrane BTI247_54470 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BTI247_54480 ENOG4105KRI phosphocarrier protein (HPr BTI247_54500 ENOG4105CHW UPF0052 protein BTI247_54510 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BTI247_54520 ENOG4108Z4K mutator MutT protein BTI247_54770 ENOG4105CYP glycoside hydrolase, family BTI247_54810 ENOG4105CAR Terminase, large subunit BTI247_54900 ENOG4105WXW Antirepressor BTI247_55020 ENOG4108IMY Transcriptional regulator BTI247_55060 ENOG4105C3M thioredoxin reductase BTI247_55080 ENOG4108S4C acetyltransferase BTI247_55120 ENOG41086DT Membrane protein of unknown function BTI247_55130 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BTI247_55190 ENOG4107TXC Transcriptional regulator BTI247_55240 ENOG4105HMI Membrane BTI247_55250 ENOG4105DUM transcriptional regulator, lysR family BTI247_55270 ENOG4108WS4 fmn reductase BTI247_55300 ENOG4105BZ1 (ABC) transporter BTI247_55320 ENOG4105CN1 protease BTI247_55330 ENOG4105CRP Part of the ABC transporter FtsEX involved in BTI247_55340 ENOG4105CAK Cell division ATP-binding protein ftsE BTI247_55360 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BTI247_55380 ENOG4105MS2 ribosomal subunit Interface protein BTI247_55390 ENOG4105VEQ Cold shock protein BTI247_55400 ENOG41081UC Inherit from COG: Competence protein BTI247_55430 ENOG4105KVH Transcriptional regulator BTI247_55450 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BTI247_55460 ENOG4108KGH TRANSCRIPTIONal BTI247_55470 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BTI247_55480 ENOG4105C6Y Udp-glucose 6-dehydrogenase BTI247_55490 ENOG4105ESV Glycosyl transferase, family 4 BTI247_55510 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BTI247_55550 ENOG4105F8D glycoside hydrolase family 4 BTI247_55560 ENOG4105VCP PTS System BTI247_55570 ENOG4105CK1 PTS System BTI247_55590 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BTI247_55600 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BTI247_55610 ENOG4105VCP PTS System BTI247_55650 ENOG4105VZJ PTS System BTI247_55690 ENOG4105ECB domain protein BTI247_55700 ENOG4107RSM transcriptional regulator BTI247_55800 ENOG4105DAA L-lactate BTI247_55820 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BTI247_55840 ENOG4105E0M Sulfatase BTI247_55890 ENOG4107R8N Glycosyl transferase, family 2 BTI247_55910 ENOG4105C94 Transporter BTI247_55920 ENOG41069ER domain protein BTI247_55970 ENOG4105KBK Zinc finger, swim domain protein BTI247_55980 ENOG4105C0D helicase BTI247_56040 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTI247_56060 ENOG4107RBB ABC transporter, permease BTI247_56070 ENOG4105C19 ABC transporter BTI247_56110 ENOG4105CXY transporter BTI247_56140 ENOG4105BZU Histidine kinase BTI247_56160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_56170 ENOG4105CMR udp-glucose 4-epimerase BTI247_56190 ENOG4108KGH TRANSCRIPTIONal BTI247_56210 ENOG4105C6Y Udp-glucose 6-dehydrogenase BTI247_56240 ENOG4107STW synthase BTI247_56260 ENOG4107SBE Glycosyl transferase (Group 1 BTI247_56270 ENOG4108PQP glycosyl transferase group 1 BTI247_56290 ENOG4105D3Q Sugar transferase BTI247_56300 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BTI247_56320 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BTI247_56330 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BTI247_56340 ENOG4107YJ4 chain length determinant protein BTI247_56350 ENOG4105HTX biosynthesis protein BTI247_56370 ENOG4107YJ4 chain length determinant protein BTI247_56400 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BTI247_56410 ENOG4105FRN stage II sporulation protein BTI247_56440 ENOG4105DY9 regulatoR BTI247_56480 ENOG4106778 Protein of unknown function (DUF1146) BTI247_56490 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BTI247_56500 ENOG4105C8S subunit m BTI247_56510 ENOG4105D65 subunit l BTI247_56560 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BTI247_56570 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BTI247_56590 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BTI247_56600 ENOG4105BZU Histidine kinase BTI247_56700 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BTI247_56710 ENOG41062M3 atp synthase BTI247_56740 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BTI247_56750 ENOG4108UIC UPF0340 protein BTI247_56760 ENOG4108YZG isomerase BTI247_56790 ENOG4108VGI doxx family BTI247_56800 ENOG4107XC4 flavin reductase domain protein, FMN-binding BTI247_56840 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BTI247_56860 ENOG4108ZXQ stage ii sporulation protein r BTI247_56870 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BTI247_56880 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BTI247_56910 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BTI247_56920 ENOG4105CBT Fructose-1,6-bisphosphatase BTI247_56930 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BTI247_56970 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BTI247_57000 ENOG4105C1G acyl-Coa dehydrogenase BTI247_57010 ENOG4105C1G acyl-Coa dehydrogenase BTI247_57020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BTI247_57040 ENOG4105DF6 Fe-S oxidoreductase BTI247_57070 ENOG4105BZU Histidine kinase BTI247_57100 ENOG4105D4Y metalloprotease BTI247_57120 ENOG4105BZU Histidine kinase BTI247_57130 ENOG4105KCT ABC transporter BTI247_57140 ENOG4108M15 ABC transporter BTI247_57150 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BTI247_57170 ENOG4105IIU Aminopeptidase BTI247_57210 ENOG4105EMN RNA polymerase sigma factor BTI247_57230 ENOG410684U Domain of unknown function (DUF1934) BTI247_57270 ENOG4105CYW agmatinase BTI247_57290 ENOG4105DXB Major Facilitator superfamily BTI247_57300 ENOG4107SWG transcriptional regulator MERR family BTI247_57310 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BTI247_57320 ENOG4105BZ4 penicillin-binding protein BTI247_57330 ENOG4108XFG YwhD family BTI247_57340 ENOG4108Z4T Peptidase M50 BTI247_57350 ENOG41069HH 4-oxalocrotonate tautomerase BTI247_57360 ENOG4105DCI Phosphohydrolase BTI247_57370 ENOG4108MES Periplasmic binding protein BTI247_57380 ENOG4105E0A ABC, transporter BTI247_57390 ENOG4105EHG Permease protein BTI247_57400 ENOG4105DQ5 transport system permease protein BTI247_57420 ENOG4108VCI transcription factor, rsfa family BTI247_57430 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BTI247_57440 ENOG4108IJ2 phosphate acetyltransferase BTI247_57450 ENOG4107UEZ chlorite dismutase BTI247_57470 ENOG4108VKI Cell wall hydrolase BTI247_57510 ENOG4107SVH Potassium channel protein BTI247_57530 ENOG410667J hydrolase BTI247_57540 ENOG4105VCH membrane BTI247_57560 ENOG4108TU7 Inherit from COG: (ABC) transporter BTI247_57570 ENOG4105CJ1 ABC, transporter BTI247_57580 ENOG41090WU lipolytic protein G-D-S-L family BTI247_57610 ENOG4105D6E homoserine dehydrogenase BTI247_57620 ENOG4105CVG Homoserine O-transsuccinylase BTI247_57660 ENOG4108Y4K DNA-binding transcriptional activator BTI247_57680 ENOG4105WH1 Two component transcriptional regulator luxr family BTI247_57690 ENOG4105BZU Histidine kinase BTI247_57700 ENOG4105DWF phosphomethylpyrimidine kinase BTI247_57710 ENOG4105BZU Histidine kinase BTI247_57720 ENOG4105VCD cytoplasmic protein BTI247_57730 ENOG4105D22 carbon starvation protein BTI247_57740 ENOG4105DY9 regulatoR BTI247_57750 ENOG41079KZ Major Facilitator Superfamily BTI247_57770 ENOG4105CG5 Glycosyl transferase (Group 1 BTI247_57790 ENOG4105EN6 Membrane BTI247_57800 ENOG4106YBV Methyl-accepting chemotaxis BTI247_57820 ENOG4108S4H thioesterase Superfamily protein BTI247_57840 ENOG4105K64 Glycosyl transferase, family 2 BTI247_57860 ENOG4105C5H ABC transporter BTI247_57890 ENOG4105CKK Glycosyl transferase, family 2 BTI247_57900 ENOG41067SE Tetr family transcriptional regulator BTI247_57920 ENOG4105E0X reductase BTI247_57930 ENOG4106F5Q Membrane BTI247_57960 ENOG4108NEV two component transcriptional regulator, LytTR family BTI247_57990 ENOG4108HRK Histidine kinase BTI247_58000 ENOG4107RGD Major Facilitator superfamily BTI247_58030 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTI247_58050 ENOG4105IW1 AmiS UreI transporter BTI247_58080 ENOG4105CMR udp-glucose 4-epimerase BTI247_58090 ENOG4108UT2 hemolysin iii BTI247_58120 ENOG4105C1J atp-dependent rna helicase BTI247_58130 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BTI247_58140 ENOG4105DPN Oligoendopeptidase f BTI247_58160 ENOG4105BZU Histidine kinase BTI247_58190 ENOG4105C0H protease BTI247_58200 ENOG4105Q2H domain protein BTI247_58230 ENOG4105BZU Histidine kinase BTI247_58240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTI247_58290 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BTI247_58300 ENOG4105CDU Replicative dna helicase BTI247_58320 ENOG4105BZR domain protein BTI247_58330 ENOG4108XMW Membrane BTI247_58350 ENOG4108UUM single-stranded DNA-binding protein BTI247_58370 ENOG4105C3G gtp-binding protein BTI247_58380 ENOG4105VDK protein, conserved in bacteria BTI247_58390 ENOG4105D8X mechanosensitive ion channel BTI247_58400 ENOG4108ZDA Sporulation protein YyaC BTI247_58410 ENOG4105FA0 parb-like partition protein BTI247_58420 ENOG4107QJE Chromosome Partitioning Protein BTI247_58450 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BTI247_58460 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BTI247_58480 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BTI247_58510 ENOG4105DQ6 Transposase BTI247_58560 ENOG4105DQ6 Transposase BTI247_58620 ENOG4105DQ6 Transposase BTI247_58690 ENOG4105DQ6 Transposase BTI247_58760 ENOG4105DQ6 Transposase BTI247_58780 ENOG4107QRS glycosyltransferase group 2 family protein BTI247_58810 ENOG4108BUD transposase BTI247_58870 ENOG4108BUD transposase BTI247_58910 ENOG4105DQ6 Transposase BTI247_58960 ENOG4105DQ6 Transposase BTI247_58970 ENOG4105FAW cDP-glucose 4,6-dehydratase BTI247_58980 ENOG4105CMR udp-glucose 4-epimerase BTI247_58990 ENOG41090R9 glycosyltransferase BTI247_59000 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BTI247_59280 ENOG4106E8G BTI247_59300 ENOG4105DQ6 Transposase BTI247_59350 ENOG4105DQ6 Transposase BTI247_59360 ENOG4105DQ6 Transposase BTI247_59380 ENOG4108BUD transposase BTI247_59460 ENOG4108BUD transposase BTI247_59620 ENOG4108BUD transposase BTI247_59690 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BTI247_59760 ENOG4105G6Z alkaline phosphatase BTI247_59810 ENOG4108BUD transposase BTI247_59820 ENOG4105E1K spore germination protein BTI247_59840 ENOG4108Q8B Spore germination protein BTI247_59910 ENOG4107RBB ABC transporter, permease BTI247_59920 ENOG4105C19 ABC transporter BTI247_59970 ENOG4108IUW ABC transporter BTI247_60130 ENOG4105D13 transposase BTI247_60210 ENOG4107QJE Chromosome Partitioning Protein BTI247_60250 ENOG4105D13 transposase BTI247_60270 ENOG4105DQ6 Transposase BTI247_60390 ENOG4105DQ6 Transposase BTI247_60460 ENOG4105DQ6 Transposase BTI247_60480 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BTI247_60490 ENOG4105E4F Isochorismate synthase BTI247_60530 ENOG4105D13 transposase BTI247_60590 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTI247_60660 ENOG4108BUD transposase BTI247_60740 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BTI247_60770 ENOG4105EXC Acyl-transferase BTI247_60810 ENOG4108V2W Carbonate dehydratase BTI247_60820 ENOG4105CHH sulfate transporter BTI247_60830 ENOG4105CHH sulfate transporter BTI247_60840 ENOG4105CHH sulfate transporter BTI247_60900 ENOG4105DQ6 Transposase BTI247_60920 ENOG4105EKQ RNA-directed DNA polymerase BTI247_61020 ENOG4108IMY Transcriptional regulator BTI247_61090 ENOG4105DQ6 Transposase BTI247_61290 ENOG4105DQ6 Transposase BTI247_61360 ENOG4105DQ6 Transposase BTI247_61380 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BTI247_61390 ENOG4105E4F Isochorismate synthase BTI247_61430 ENOG4105D13 transposase BTI247_61520 ENOG4108BUD transposase BTI247_61600 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTI247_61660 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BTI247_61690 ENOG4105EXC Acyl-transferase BTI247_61730 ENOG4108V2W Carbonate dehydratase BTI247_61740 ENOG4105EKQ RNA-directed DNA polymerase BTI247_62040 ENOG4105CNU cell division protein FtsK BTI247_62180 ENOG410607W Transposase BTI247_62200 ENOG4105DQ6 Transposase BTI247_62230 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTI247_62320 ENOG4105D13 transposase BTI247_62410 ENOG4108BUD transposase BTI247_62430 ENOG4105D13 transposase BTI247_62450 ENOG4105D13 transposase BTI247_62520 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTI247_62560 ENOG4108B1Q Ribonuclease BTI247_62640 ENOG4105D13 transposase BTI247_62760 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BTI247_62770 ENOG4105KRN Transcriptional regulator, abrb family BTI247_62790 ENOG4108UUM single-stranded DNA-binding protein BTI247_62950 ENOG4105K4H Nlp p60 protein BTI247_63030 ENOG4108IMY Transcriptional regulator BTI247_63080 ENOG4105DQ6 Transposase BTI247_63210 ENOG4105EKQ RNA-directed DNA polymerase BTI247_63250 ENOG410836F Transposase BTI247_63360 ENOG4105DQ6 Transposase BTI247_63510 ENOG41082J7 Rhodanese domain protein BTI247_63600 ENOG4108BUD transposase BTI247_63620 ENOG4108IJ6 ABC transporter BTI247_63700 ENOG4105C9U ATP-dependent DNA helicase RecQ BTI247_63710 ENOG4105C9U ATP-dependent DNA helicase RecQ BTI247_63750 ENOG4105KRN Transcriptional regulator, abrb family BTI247_63760 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTI247_63870 ENOG4105DQ6 Transposase BTI247_63970 ENOG4105D13 transposase