locus-tag class description AXW78_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AXW78_00015 ENOG410848D S4 domain protein YaaA AXW78_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AXW78_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AXW78_00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AXW78_00100 ENOG4105ZMH deoxynucleoside kinase AXW78_00110 ENOG4105GTG Isochorismatase AXW78_00115 ENOG4108Z6B deaminase AXW78_00125 ENOG4105C6E dna polymerase iii AXW78_00145 ENOG41067KS pro-sigma K processing AXW78_00180 ENOG4105CXN decarboxylase AXW78_00190 ENOG4105FA2 dna polymerase iii AXW78_00195 ENOG4105MA4 psp1 domain protein AXW78_00205 ENOG41060K3 Methyltransferase AXW78_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AXW78_00220 ENOG4105KRN Transcriptional regulator, abrb family AXW78_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AXW78_00230 ENOG4105F8V Hydrolase, tatD family AXW78_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AXW78_00245 ENOG4105XFA sporulation peptidase YabG AXW78_00250 ENOG4105W42 Veg protein AXW78_00265 ENOG4105DFT pur operon repressor AXW78_00270 ENOG4105KME endoribonuclease L-psp AXW78_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AXW78_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AXW78_00300 ENOG4108JA2 transcriptioN-repair coupling factor AXW78_00305 ENOG4108M14 stage v sporulation protein t AXW78_00315 ENOG4108IY2 MazG family AXW78_00320 ENOG41082I2 s4 domain protein AXW78_00325 ENOG4105VYY sporulation protein yabp AXW78_00340 ENOG41060GV RNA binding s1 domain protein AXW78_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AXW78_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase AXW78_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AXW78_00385 ENOG4105C6T cysteine synthase AXW78_00390 ENOG4105CRQ synthase (Component I) AXW78_00395 ENOG4105DDQ anthranilate synthase AXW78_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AXW78_00405 ENOG4105EEI dihydropteroate synthase AXW78_00410 ENOG4105KRF dihydroneopterin aldolase AXW78_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AXW78_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AXW78_00515 ENOG4108Z0C Uvrb UvrC protein AXW78_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AXW78_00540 ENOG4105CTP PilT protein domain protein AXW78_00545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AXW78_00560 ENOG4105D7W serine acetyltransferase AXW78_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 AXW78_00580 ENOG4105M0M Tetracycline resistance protein AXW78_00585 ENOG4105QIV RNA polymerase AXW78_00595 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AXW78_00620 ENOG4107Y49 methyltransferase AXW78_00635 ENOG4105XPM ribosomal protein AXW78_00740 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AXW78_00765 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AXW78_00775 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AXW78_00785 ENOG41067V7 50S ribosomal protein L36 AXW78_00815 ENOG4108JJB ABC transporter AXW78_00820 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AXW78_00825 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AXW78_00850 ENOG4105D1F ATP-binding protein AXW78_00865 ENOG4108NMV polysaccharide deacetylase AXW78_00945 ENOG4105C8B TIGR00159 family AXW78_00950 ENOG4107U5W ybbr family AXW78_00965 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AXW78_00990 ENOG4108PSK reductase AXW78_00995 ENOG4108UMI ABC transporter, permease AXW78_01000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AXW78_01005 ENOG4105D01 (LipO)protein AXW78_01010 ENOG4105CB2 alcohol dehydrogenase AXW78_01035 ENOG4105C2C drug resistance transporter, Bcr CflA AXW78_01070 ENOG4108J59 Extracellular solute-binding protein, family 5 AXW78_01090 ENOG4105E0C molybdate abc transporter AXW78_01095 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AXW78_01100 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AXW78_01105 ENOG4105EGI Transcriptional regulator AXW78_01120 ENOG4105F6E Acyl-transferase AXW78_01135 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AXW78_01155 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AXW78_01175 ENOG4105C5H ABC transporter AXW78_01185 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AXW78_01195 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AXW78_01200 ENOG4105C3U ABC transporter AXW78_01205 ENOG4108JQ7 (ABC) transporter AXW78_01210 ENOG410667J hydrolase AXW78_01235 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AXW78_01240 ENOG4105ERH Fumarylacetoacetate hydrolase AXW78_01250 ENOG4105CUB amino acid AXW78_01255 ENOG4108SC4 )-transporter AXW78_01260 ENOG4105CPF Cell wall formation (By similarity) AXW78_01265 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AXW78_01290 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AXW78_01295 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AXW78_01305 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AXW78_01400 ENOG4107ZXU DSBA oxidoreductase AXW78_01430 ENOG4105K8N protein family UPF0079, ATPase AXW78_01435 ENOG41072GX Peptidase M22 Glycoprotease AXW78_01440 ENOG410801F ribosomal-protein-alanine acetyltransferase AXW78_01445 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AXW78_01450 ENOG4105C5H ABC transporter AXW78_01465 ENOG4108TYN CAAX amino terminal protease family protein AXW78_01485 ENOG4105C7N Xanthine uracil vitamin C permease AXW78_01495 ENOG4105BZU Histidine kinase AXW78_01525 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AXW78_01545 ENOG4108SHN Glycosyl transferase, family 2 AXW78_01590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXW78_01610 ENOG4105SX7 Transporter AXW78_01635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AXW78_01640 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AXW78_01645 ENOG4105C83 adenylosuccinate lyase AXW78_01655 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AXW78_01680 ENOG4108V3E phosphoribosylglycinamide formyltransferase AXW78_01685 ENOG4105DC1 bifunctional purine biosynthesis protein purh AXW78_01690 ENOG4105C12 Phosphoribosylglycinamide synthetase AXW78_01715 ENOG4105C4R Atp-dependent dna helicase AXW78_01720 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AXW78_01740 ENOG4108W2Y isochorismatase AXW78_01745 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AXW78_01750 ENOG4108UMI ABC transporter, permease AXW78_01755 ENOG4105D01 (LipO)protein AXW78_01760 ENOG410834F Transcriptional regulator AXW78_01765 ENOG4107I77 yiaA/B two helix domain AXW78_01785 ENOG4105CBD Diacylglycerol kinase AXW78_01795 ENOG4108JPW Aminotransferase AXW78_01805 ENOG4105C26 Dehydrogenase AXW78_01810 ENOG4105KPY Small multidrug resistance protein AXW78_01835 ENOG4105D9N nucleoside AXW78_01840 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AXW78_01850 ENOG4108W15 Protein of unknown function (DUF1456) AXW78_01865 ENOG4105DTQ mandelate racemase muconate lactonizing AXW78_01875 ENOG4105DFD Na H antiporter AXW78_01895 ENOG4105D3R alkyl hydroperoxide reductase AXW78_01900 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AXW78_01905 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AXW78_01910 ENOG4107W7X Aldolase AXW78_01915 ENOG4105EHG Permease protein AXW78_01920 ENOG4105DQ5 transport system permease protein AXW78_01925 ENOG4108V5C ABC transporter AXW78_01930 ENOG4105CAY ferredoxin--nadp reductase AXW78_01945 ENOG4106UIA AXW78_01950 ENOG4106UIA AXW78_01965 ENOG4105BZU Histidine kinase AXW78_01985 ENOG410756H nucleotidyltransferase AXW78_01990 ENOG4105D2S major facilitator superfamily AXW78_02005 ENOG4105E5Q amino acid AbC transporter AXW78_02010 ENOG4105EAB amino acid AbC transporter AXW78_02020 ENOG4105C8Q Methyl-accepting chemotaxis AXW78_02035 ENOG4105DBV ornithine carbamoyltransferase AXW78_02045 ENOG4105C5B carbamate kinase AXW78_02050 ENOG4108W63 CRP FNR family transcriptional regulator AXW78_02065 ENOG4105CI1 PTS System AXW78_02080 ENOG4105C9U ATP-dependent DNA helicase RecQ AXW78_02095 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AXW78_02115 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AXW78_02120 ENOG4105D2X ABC transporter substrate-binding protein AXW78_02155 ENOG41062JF Transcriptional regulator AXW78_02170 ENOG4105DEU major facilitator superfamily AXW78_02185 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AXW78_02200 ENOG4108N0M stress protein AXW78_02205 ENOG4106FN3 tellurium resistance protein AXW78_02210 ENOG4106FN3 tellurium resistance protein AXW78_02215 ENOG4107TS3 membrane protein, TerC AXW78_02220 ENOG4108TTB tellurium resistance protein AXW78_02235 ENOG41068PA UPF0435 protein AXW78_02240 ENOG4105KJF protein tyrosine phosphatase AXW78_02250 ENOG4107U9T Pfam:Ribonuclease_BN AXW78_02255 ENOG4105C59 p-type ATPase AXW78_02260 ENOG4108IPJ Membrane AXW78_02280 ENOG4107ZTW SNARE associated Golgi AXW78_02295 ENOG410606W general stress protein AXW78_02300 ENOG4105UPD Calcium Proton AXW78_02340 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AXW78_02350 ENOG4108JUB Transcriptional regulator AXW78_02360 ENOG4108IQI permease AXW78_02395 ENOG4108A04 Beta-lactamase AXW78_02410 ENOG4105CKK Glycosyl transferase, family 2 AXW78_02415 ENOG4107QQG Dehydrogenase AXW78_02420 ENOG4105C3I Nad-dependent epimerase dehydratase AXW78_02435 ENOG4105F1A Pyruvate formate-lyase AXW78_02440 ENOG4108QBV Monogalactosyldiacylglycerol synthase AXW78_02455 ENOG4105CI2 imidazolone-5-propionate hydrolase AXW78_02460 ENOG4105ECP epimerase AXW78_02490 ENOG41067AE Membrane-bound metal-dependent hydrolase AXW78_02495 ENOG4105CEN a g-specific adenine glycosylase AXW78_02500 ENOG4106BXE AXW78_02520 ENOG4105BZ1 (ABC) transporter AXW78_02525 ENOG4107NBY Membrane AXW78_02530 ENOG4105CBC glutamate synthase AXW78_02540 ENOG4108IUW ABC transporter AXW78_02560 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AXW78_02565 ENOG4105G5W regulator Fur family AXW78_02675 ENOG4105CDY transcriptional regulatory protein AXW78_02685 ENOG4108JQC penicillin-binding protein 1A AXW78_02690 ENOG4108R9S DSBA oxidoreductase AXW78_02700 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AXW78_02710 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AXW78_02720 ENOG4105CYN Serine protein kinase AXW78_02735 ENOG4105C94 Transporter AXW78_02750 ENOG4105DZ6 Band 7 protein AXW78_02760 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AXW78_02765 ENOG4108V9W transcriptional regulatory protein AXW78_02770 ENOG4105D4T Citrate transporter AXW78_02795 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AXW78_02800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AXW78_02805 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AXW78_02810 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AXW78_02815 ENOG4105BZ7 extracellular solute-binding protein family 1 AXW78_02820 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AXW78_02825 ENOG4108STX response regulator AXW78_02830 ENOG4105US7 Histidine kinase AXW78_02855 ENOG4108MRH transcriptional regulatory protein AXW78_02865 ENOG4105C6K Malic enzyme AXW78_02875 ENOG4108UZ3 Transporter AXW78_02880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AXW78_02890 ENOG4105BZU Histidine kinase AXW78_02910 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AXW78_02915 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AXW78_02920 ENOG4108JB9 formate dehydrogenase AXW78_02940 ENOG4105CUB amino acid AXW78_02950 ENOG4105C59 p-type ATPase AXW78_02955 ENOG4105DAP Nicotinate phosphoribosyltransferase AXW78_02985 ENOG41073R8 VanW family AXW78_02990 ENOG4108KGH TRANSCRIPTIONal AXW78_02995 ENOG4105D9N nucleoside AXW78_03000 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AXW78_03005 ENOG4105C37 (CBS) domain AXW78_03010 ENOG4108IJ0 Aspartate ammonia-lyase AXW78_03015 ENOG4105DAA L-lactate AXW78_03030 ENOG4105DUX Transporter AXW78_03035 ENOG4108MES Periplasmic binding protein AXW78_03040 ENOG4105DQ5 transport system permease protein AXW78_03045 ENOG4108IHU transport system permease protein AXW78_03050 ENOG4105E0A ABC, transporter AXW78_03065 ENOG4105EXW epimerase dehydratase AXW78_03075 ENOG4107T89 von Willebrand factor, type A AXW78_03080 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AXW78_03085 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AXW78_03095 ENOG4105BZU Histidine kinase AXW78_03100 ENOG4105D5Q Arginine ornithine antiporter AXW78_03105 ENOG4107414 GntR family transcriptional regulator AXW78_03110 ENOG4105C5Y PTS System AXW78_03115 ENOG4105CG3 alpha amylase, catalytic region AXW78_03130 ENOG4105E1K spore germination protein AXW78_03135 ENOG4105CRN Aminoglycoside phosphotransferase AXW78_03140 ENOG4105BZG amino acid carrier protein AXW78_03150 ENOG4105CDA abc transporter atp-binding protein AXW78_03155 ENOG4105CT1 (ABC) transporter AXW78_03160 ENOG4105EAD ABC transporter AXW78_03165 ENOG4105DRP amino acid AbC transporter AXW78_03170 ENOG4108IQI permease AXW78_03185 ENOG4105GFR rna polymerase sigma factor AXW78_03195 ENOG4105D29 Helix-turn-helix type 11 domain protein AXW78_03200 ENOG4105NAE bifunctional deaminase-reductase domain protein AXW78_03205 ENOG4105BZU Histidine kinase AXW78_03220 ENOG4105CHH sulfate transporter AXW78_03225 ENOG41068KF Universal stress protein AXW78_03235 ENOG4105CXY transporter AXW78_03240 ENOG41067TZ transcriptional regulator, MarR family AXW78_03245 ENOG4105C0R drug resistance transporter emrb qaca subfamily AXW78_03250 ENOG4105ETE Transcriptional regulator (LacI family AXW78_03255 ENOG4108RVA ribokinase AXW78_03265 ENOG4105C2J ABC transporter AXW78_03270 ENOG4105CNN ABC, transporter AXW78_03275 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AXW78_03280 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AXW78_03315 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) AXW78_03345 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AXW78_03350 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AXW78_03355 ENOG41069ER domain protein AXW78_03360 ENOG4105VZ8 Transcriptional regulator AXW78_03365 ENOG4107D63 AXW78_03380 ENOG4105DUX Transporter AXW78_03400 ENOG4105C85 amino acid AXW78_03405 ENOG4105C7N Xanthine uracil vitamin C permease AXW78_03420 ENOG4105MA6 gCN5-related N-acetyltransferase AXW78_03445 ENOG4105BZ9 Cytochrome C oxidase, subunit I AXW78_03450 ENOG4105E2S oxidase) subunit II AXW78_03470 ENOG4106CAD Protein of unknown function (DUF3311) AXW78_03475 ENOG4105E1V na solute symporter AXW78_03490 ENOG4108NHD germination protein AXW78_03495 ENOG4105CE1 Ferrous iron transport protein b AXW78_03500 ENOG4105CE1 Ferrous iron transport protein b AXW78_03505 ENOG4105CE1 Ferrous iron transport protein b AXW78_03510 ENOG4105CVA phosphate AXW78_03515 ENOG4105C8U phosphate abc transporter AXW78_03520 ENOG4105E2Z phosphate ABC transporter (Permease AXW78_03650 ENOG41080XQ Signal transduction protein with cbs domains AXW78_03670 ENOG4105ETU transcriptional activator (TenA AXW78_03680 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AXW78_03690 ENOG4108VEU Thiamine monophosphate synthase AXW78_03695 ENOG41080HI glycine oxidase AXW78_03710 ENOG4105D06 uba thif-type nad fad binding protein AXW78_03715 ENOG4105DWF phosphomethylpyrimidine kinase AXW78_03735 ENOG4105C19 ABC transporter AXW78_03740 ENOG4105C3F Signal peptidase i AXW78_03790 ENOG4108INS Transcriptional regulator AXW78_03805 ENOG4105C7N Xanthine uracil vitamin C permease AXW78_03815 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AXW78_03835 ENOG4105C5Y PTS System AXW78_03850 ENOG4105K63 Thioredoxin AXW78_03870 ENOG4108B31 Spore germination protein AXW78_03890 ENOG4107Y03 Nitroreductase AXW78_03895 ENOG4105ED1 spovr family AXW78_03905 ENOG41085GJ domain protein AXW78_03910 ENOG4105XTG Pfam:DUF156 AXW78_03915 ENOG4105VFE sira family AXW78_03920 ENOG4107TPS domain protein AXW78_03925 ENOG4105VFE sira family AXW78_03930 ENOG4105VFE sira family AXW78_03935 ENOG41085GJ domain protein AXW78_03940 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AXW78_03945 ENOG41087NI Sulfite exporter TauE/SafE AXW78_03955 ENOG4108KGH TRANSCRIPTIONal AXW78_03980 ENOG4105EMD TRANSCRIPTIONal AXW78_03985 ENOG4105VCP PTS System AXW78_03990 ENOG4105VZJ PTS System AXW78_04015 ENOG41069ER domain protein AXW78_04020 ENOG4107RBB ABC transporter, permease AXW78_04025 ENOG4105C19 ABC transporter AXW78_04055 ENOG4105WEF catalase AXW78_04090 ENOG4107T5V SNARE associated Golgi AXW78_04120 ENOG4105CUB amino acid AXW78_04125 ENOG4107RWR Sodium hydrogen exchanger AXW78_04135 ENOG4106KNT transcriptional regulator AXW78_04175 ENOG4108YXU transcriptional regulator AsnC family AXW78_04185 ENOG4105KPY Small multidrug resistance protein AXW78_04190 ENOG4105KPY Small multidrug resistance protein AXW78_04205 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AXW78_04210 ENOG410605W Major Facilitator AXW78_04220 ENOG4107RKG DJ-1/PfpI family AXW78_04225 ENOG4105CH6 catalase AXW78_04235 ENOG4105D5Q Arginine ornithine antiporter AXW78_04240 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AXW78_04250 ENOG4105C26 Dehydrogenase AXW78_04255 ENOG4105BZ1 (ABC) transporter AXW78_04260 ENOG4105BZ1 (ABC) transporter AXW78_04270 ENOG4105DRP amino acid AbC transporter AXW78_04275 ENOG4105CDA abc transporter atp-binding protein AXW78_04290 ENOG410839P AXW78_04325 ENOG4107FQX Alpha-acetolactate decarboxylase AXW78_04350 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AXW78_04355 ENOG4105D4P Coproporphyrinogen iii oxidase AXW78_04360 ENOG4105CEY Amp-dependent synthetase and ligase AXW78_04375 ENOG4105CHH sulfate transporter AXW78_04400 ENOG4105CGU Enoyl-CoA hydratase AXW78_04420 ENOG4105DER m42 family AXW78_04465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AXW78_04470 ENOG4105C3U ABC transporter AXW78_04475 ENOG4108JQ7 (ABC) transporter AXW78_04515 ENOG4108IBT Inherit from COG: transposase AXW78_04540 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) AXW78_04590 ENOG4105CSH Transporter AXW78_04600 ENOG4108MRH transcriptional regulatory protein AXW78_04655 ENOG4105CDU Replicative dna helicase AXW78_04675 ENOG4105C0R drug resistance transporter emrb qaca subfamily AXW78_04690 ENOG4105DQ6 Transposase AXW78_04715 ENOG4105F6J Alpha beta hydrolase fold AXW78_04760 ENOG4107P5I polyketide synthase AXW78_04765 ENOG4108IG5 Transcriptional regulator AXW78_04780 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AXW78_04795 ENOG4105CMT Dihydroxyacetone kinase AXW78_04870 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AXW78_04955 ENOG4105WN5 stage II sporulation protein AXW78_04965 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXW78_04975 ENOG4108MJI response regulator AXW78_04980 ENOG4105BZU Histidine kinase AXW78_04985 ENOG4105BZU Histidine kinase AXW78_05005 ENOG4105K8R UPF0145 protein AXW78_05015 ENOG4105D7V transposase AXW78_05030 ENOG4105ENE Histidine kinase AXW78_05035 ENOG4108VB1 regulatoR AXW78_05060 ENOG4107VRP DNA repair exonuclease AXW78_05065 ENOG4106D4I domain protein AXW78_05095 ENOG4108MUZ hydrolase AXW78_05115 ENOG4105F0F Oxalate decarboxylase AXW78_05120 ENOG41067QW Transcriptional regulator AXW78_05125 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AXW78_05140 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AXW78_05150 ENOG4105EMN RNA polymerase sigma factor AXW78_05165 ENOG4105EEM helicase AXW78_05175 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AXW78_05200 ENOG4105K59 histidine triad (HIT) protein AXW78_05230 ENOG410905X membrane-flanked domain protein AXW78_05235 ENOG4105CKV Membrane AXW78_05275 ENOG410905X membrane-flanked domain protein AXW78_05280 ENOG4105CKV Membrane AXW78_05285 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AXW78_05290 ENOG4105BZ4 penicillin-binding protein AXW78_05300 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AXW78_05305 ENOG4105C1Q protoporphyrinogen oxidase AXW78_05330 ENOG4105NA0 Transcriptional regulator AXW78_05345 ENOG4105ECB domain protein AXW78_05365 ENOG4108MK9 spermidine N(1)-acetyltransferase AXW78_05380 ENOG4108RQ5 Beta-lactamase domain-containing protein AXW78_05385 ENOG4105DF9 Lipoate-protein, ligase AXW78_05395 ENOG4105CEY Amp-dependent synthetase and ligase AXW78_05410 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) AXW78_05415 ENOG4107RN3 metallophosphoesterase AXW78_05420 ENOG4107TVP HD domain protein AXW78_05430 ENOG4108AEY RNA polymerase sigma factor AXW78_05435 ENOG41086D8 Transcriptional regulator AXW78_05445 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXW78_05465 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AXW78_05470 ENOG4105C8Q Methyl-accepting chemotaxis AXW78_05475 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AXW78_05485 ENOG4107QP3 malate synthase g AXW78_05505 ENOG4105VEQ Cold shock protein AXW78_05540 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AXW78_05545 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AXW78_05585 ENOG4105ERH Fumarylacetoacetate hydrolase AXW78_05595 ENOG4105C8Y Acetylornithine aminotransferase AXW78_05610 ENOG4105CAQ asparagine synthetase AXW78_05615 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AXW78_05620 ENOG4105CH6 catalase AXW78_05625 ENOG4105BZU Histidine kinase AXW78_05640 ENOG4108VPT UPF0234 protein AXW78_05645 ENOG4105QNR S1 RNA binding domain protein AXW78_05650 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AXW78_05655 ENOG4107AYK membrAne AXW78_05660 ENOG41073B9 AXW78_05670 ENOG4108KP7 hydrolase AXW78_05680 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AXW78_05705 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AXW78_05710 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AXW78_05725 ENOG4105C31 Tryptophanyl-tRNA synthetase AXW78_05740 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AXW78_05745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AXW78_05755 ENOG4108JQ7 (ABC) transporter AXW78_05760 ENOG4105UQX Mate efflux family protein AXW78_05780 ENOG4108ZCF integral membrane protein AXW78_05790 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AXW78_05800 ENOG4105DPN Oligoendopeptidase f AXW78_05810 ENOG4108Z18 K06886 hemoglobin AXW78_05815 ENOG4105MIX Adenylate cyclase AXW78_05820 ENOG4106EFP UPF0738 protein AXW78_05830 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AXW78_05835 ENOG4105EMS pseudouridine synthase AXW78_05855 ENOG4105K64 Glycosyl transferase, family 2 AXW78_05885 ENOG4107TVC Glycosyl transferase, family 2 AXW78_05905 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AXW78_05910 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AXW78_05920 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AXW78_05970 ENOG4108ZMI UPF0477 protein AXW78_05995 ENOG4105CK7 Sodium proline symporter AXW78_06005 ENOG4105CRQ synthase (Component I) AXW78_06010 ENOG4105DDQ anthranilate synthase AXW78_06105 ENOG4105C7S Dehydrogenase AXW78_06115 ENOG4105VZ8 Transcriptional regulator AXW78_06165 ENOG4105DZ1 carboxypeptidase AXW78_06170 ENOG4105VFR signal peptidase AXW78_06205 ENOG4105C26 Dehydrogenase AXW78_06210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AXW78_06215 ENOG4105F38 ABC transporter, permease AXW78_06220 ENOG4105D38 putrescine abc transporter AXW78_06225 ENOG4107RUE extracellular solute-binding protein family 1 AXW78_06235 ENOG4105EYF MMPL domain protein AXW78_06245 ENOG4108YBP pseudouridine synthase AXW78_06255 ENOG4105K4I Scp-like extracellular AXW78_06260 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AXW78_06265 ENOG4105CQB FAD linked oxidase domain protein AXW78_06280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_06285 ENOG4105BZU Histidine kinase AXW78_06290 ENOG4105JXH GntR family transcriptional regulator AXW78_06310 ENOG4106A3R peptidase AXW78_06320 ENOG4108QTI )-transporter AXW78_06325 ENOG4107TS3 membrane protein, TerC AXW78_06330 ENOG4105CZN Potassium uptake protein AXW78_06335 ENOG410681C small acid-soluble spore protein AXW78_06340 ENOG4108Z7G MaoC domain protein dehydratase AXW78_06360 ENOG4105CHR reductase AXW78_06390 ENOG4105C4Y ABC transporter AXW78_06395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AXW78_06400 ENOG4107RCV ABC transporter, permease AXW78_06420 ENOG4105E98 transcriptional regulator DeoR family AXW78_06435 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AXW78_06445 ENOG4105PXI polysaccharide deacetylase AXW78_06455 ENOG4105BZU Histidine kinase AXW78_06460 ENOG41090MY MarR family Transcriptional regulator AXW78_06470 ENOG4106DF1 AXW78_06480 ENOG4105BZU Histidine kinase AXW78_06485 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AXW78_06490 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AXW78_06495 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AXW78_06535 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AXW78_06540 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AXW78_06545 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AXW78_06550 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AXW78_06555 ENOG4105CZV ABC transporter AXW78_06565 ENOG4105CJ1 ABC, transporter AXW78_06605 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AXW78_06610 ENOG4105EA8 2-Nitropropane dioxygenase AXW78_06615 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AXW78_06625 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AXW78_06650 ENOG4105NQC Flavodoxin AXW78_06690 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AXW78_06725 ENOG4105CZN Potassium uptake protein AXW78_06730 ENOG41063Y9 AXW78_06735 ENOG4105KBJ sporulation protein ytfj AXW78_06755 ENOG4105CM2 brancheD-chain amino acid aminotransferase AXW78_06760 ENOG4105C7K acetolactate synthase AXW78_06765 ENOG4108ZP8 Acetolactate synthase small subunit AXW78_06770 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AXW78_06785 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AXW78_06800 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AXW78_06805 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AXW78_06810 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AXW78_06815 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AXW78_06820 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AXW78_06825 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AXW78_06840 ENOG4107RVV histidinol phosphate phosphatase, hisj family AXW78_06855 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AXW78_06860 ENOG4105E0M Sulfatase AXW78_06870 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AXW78_06885 ENOG4107S4M Sulfate adenylate transferase AXW78_06890 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AXW78_06895 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AXW78_06905 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AXW78_06910 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AXW78_06915 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AXW78_06920 ENOG4105C8J )-transporter AXW78_06940 ENOG4105DFD Na H antiporter AXW78_06960 ENOG4105ENE Histidine kinase AXW78_06965 ENOG4105WH1 Two component transcriptional regulator luxr family AXW78_06985 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AXW78_07010 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AXW78_07030 ENOG4105CJ3 phosphate transporter AXW78_07035 ENOG4107GRR phosphate transport regulator AXW78_07040 ENOG4105BZ4 penicillin-binding protein AXW78_07055 ENOG4105BZU Histidine kinase AXW78_07060 ENOG4105I3N Conserved Protein AXW78_07075 ENOG4105BZU Histidine kinase AXW78_07105 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AXW78_07110 ENOG4105DZ1 carboxypeptidase AXW78_07115 ENOG4108JIC nucleoside recognition domain protein AXW78_07125 ENOG4105FE9 pseudouridine synthase AXW78_07130 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AXW78_07135 ENOG4107TWT Cytochrome c biogenesis protein AXW78_07140 ENOG4105CRE cytochrome C AXW78_07145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_07150 ENOG4105BZU Histidine kinase AXW78_07170 ENOG4108SAX Membrane AXW78_07185 ENOG4105C9U ATP-dependent DNA helicase RecQ AXW78_07190 ENOG4105I7S Abortive infection protein AXW78_07200 ENOG4107RGJ metallophosphoesterase AXW78_07205 ENOG4108XDN Transcriptional regulator AXW78_07210 ENOG4108S6Z Negative regulator of genetic competence AXW78_07235 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AXW78_07240 ENOG4107RB3 L-asparaginase AXW78_07255 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AXW78_07270 ENOG4105S2F AXW78_07275 ENOG41065D1 AXW78_07305 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AXW78_07320 ENOG4105XXQ heptaprenyl diphosphate synthase component I AXW78_07330 ENOG4105EAH synthase AXW78_07335 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AXW78_07340 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AXW78_07355 ENOG41068YB TPR repeat-containing protein AXW78_07370 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AXW78_07375 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AXW78_07410 ENOG4108JYZ YitT family AXW78_07415 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AXW78_07430 ENOG4105FJR Lmbe family AXW78_07435 ENOG4105CPK Glycosyl transferase (Group 1 AXW78_07450 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AXW78_07465 ENOG4105DVT helicase AXW78_07470 ENOG4105YAC AXW78_07490 ENOG4105CSM endonuclease III AXW78_07500 ENOG4105BZ4 penicillin-binding protein AXW78_07555 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AXW78_07565 ENOG4105DVT helicase AXW78_07570 ENOG4105CTD carboxy-peptidase AXW78_07580 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AXW78_07585 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AXW78_07590 ENOG4105C2W permease AXW78_07595 ENOG4105DHF Membrane AXW78_07600 ENOG410890F Dynamin family AXW78_07610 ENOG4108W0I acetyltransferase AXW78_07620 ENOG4105KHC sulfurtransferase AXW78_07645 ENOG4106032 Glutathionylspermidine synthase AXW78_07675 ENOG4105HTX biosynthesis protein AXW78_07705 ENOG4105CPK Glycosyl transferase (Group 1 AXW78_07740 ENOG41081VK Ribonuclease AXW78_07805 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AXW78_07815 ENOG4107RWR Sodium hydrogen exchanger AXW78_07820 ENOG4108Z5V transcriptional regulator, merr family AXW78_07830 ENOG4105H67 Protein of unknown function (DUF421) AXW78_07835 ENOG41080C8 DUF218 domain AXW78_07865 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AXW78_07875 ENOG4107R0U MotA TolQ exbB proton channel AXW78_07880 ENOG4105ER2 Ompa motb domain protein AXW78_07885 ENOG4107YTP response regulator receiver protein AXW78_07890 ENOG4105CBS Chea signal transduction histidine kinase AXW78_07895 ENOG4105DD5 Flagellar motor switch protein AXW78_07910 ENOG4105BZU Histidine kinase AXW78_07930 ENOG4105E1Q flagellar hook-associated protein AXW78_07935 ENOG4105DTJ flagellar hook-associated protein AXW78_07955 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AXW78_07960 ENOG4108ZC9 flagellar basal-body rod protein flgc AXW78_07965 ENOG41075Z6 flagellar hook-basal body complex protein fliE AXW78_07970 ENOG4107U2N Flagellar M-ring protein AXW78_07975 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AXW78_08005 ENOG4105BZE flagellar hook protein, FlgE AXW78_08020 ENOG4107R88 Chemotaxis protein (CheV) AXW78_08035 ENOG4105I03 Flagellin AXW78_08040 ENOG4105I03 Flagellin AXW78_08045 ENOG4105I03 Flagellin AXW78_08050 ENOG4105E4C Lytic transglycosylase catalytic AXW78_08060 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AXW78_08065 ENOG4105DD5 Flagellar motor switch protein AXW78_08075 ENOG4105CN7 Flagellar biosynthetic protein FliP AXW78_08080 ENOG4105VS8 Flagellar biosynthetic protein fliq AXW78_08090 ENOG4105D00 flagellar biosynthetic protein flhB AXW78_08095 ENOG4105D7B Flagellar biosynthesis protein flha AXW78_08100 ENOG4105FZW flagellar biosynthesis regulator FlhF AXW78_08110 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AXW78_08140 ENOG4105KAC Antibiotic biosynthesis monooxygenase AXW78_08145 ENOG4107QZ7 Cellulose synthase catalytic subunit AXW78_08170 ENOG4105DUM transcriptional regulator, lysR family AXW78_08185 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AXW78_08215 ENOG4105CVJ phosphoglycerate mutase AXW78_08225 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AXW78_08245 ENOG4105CAQ asparagine synthetase AXW78_08265 ENOG4105PGM cation diffusion facilitator family transporter AXW78_08275 ENOG4105DRR Transcriptional regulator, GntR family AXW78_08280 ENOG4108UZ3 Transporter AXW78_08285 ENOG4105CKI cobalamin synthesis protein AXW78_08290 ENOG4108PJD permease AXW78_08305 ENOG4105DFD Na H antiporter AXW78_08310 ENOG4105VUF Transcriptional regulator AXW78_08320 ENOG4105C9Q fumarate hydratase class II AXW78_08335 ENOG4107QJQ Mate efflux family protein AXW78_08340 ENOG4105EC3 peptidase S51, dipeptidase E AXW78_08380 ENOG4106BRA Membrane AXW78_08415 ENOG4105CJ1 ABC, transporter AXW78_08435 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AXW78_08445 ENOG4108IJ0 Aspartate ammonia-lyase AXW78_08450 ENOG4105C6K Malic enzyme AXW78_08505 ENOG4105FVX AXW78_08510 ENOG4105E09 nadh pyrophosphatase AXW78_08530 ENOG4105CSR polyphosphate kinase 2 AXW78_08535 ENOG4105U3E Transcriptional regulator AXW78_08550 ENOG4105DXI Major Facilitator superfamily AXW78_08560 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AXW78_08565 ENOG4105EU0 Major facilitator Superfamily AXW78_08570 ENOG4105C6T cysteine synthase AXW78_08590 ENOG4105C8J )-transporter AXW78_08600 ENOG4105X5K response regulator receiver protein AXW78_08605 ENOG4105H67 Protein of unknown function (DUF421) AXW78_08630 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AXW78_08635 ENOG4105CHR reductase AXW78_08640 ENOG4105CM2 brancheD-chain amino acid aminotransferase AXW78_08645 ENOG4105C7K acetolactate synthase AXW78_08655 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AXW78_08665 ENOG4105C7B Threonine dehydratase AXW78_08690 ENOG4105C6X Major Facilitator AXW78_08695 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AXW78_08705 ENOG4105DY9 regulatoR AXW78_08710 ENOG4105CYC Transferase AXW78_08735 ENOG41068WN AXW78_08755 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AXW78_08770 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AXW78_08780 ENOG4105C0X amino acid AXW78_08805 ENOG4105K8R UPF0145 protein AXW78_08820 ENOG4107RHR regulatoR AXW78_08830 ENOG4105D9N nucleoside AXW78_08835 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AXW78_08855 ENOG4107RAQ aminopeptidase AXW78_08865 ENOG4107R16 Multicopper oxidase AXW78_08905 ENOG4108T5E Copper resistance protein AXW78_08910 ENOG4105KTB nuclear export factor GLE1 AXW78_08915 ENOG4107RT3 EamA-like transporter family AXW78_08920 ENOG4105GZI Transcriptional regulator AXW78_08925 ENOG4108Z40 Transcriptional regulator AXW78_08930 ENOG4107ZXU DSBA oxidoreductase AXW78_08935 ENOG4108TVJ Nitroreductase AXW78_08945 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AXW78_09035 ENOG4105C2M dna polymerase I AXW78_09115 ENOG4105KRN Transcriptional regulator, abrb family AXW78_09130 ENOG4107QPV Serine Threonine protein kinase AXW78_09150 ENOG4108C33 Resolvase AXW78_09260 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AXW78_09270 ENOG4105DQ6 Transposase AXW78_09285 ENOG4105DHP deoxycytidine triphosphate deaminase AXW78_09340 ENOG4108SVB resolvase AXW78_09350 ENOG4106F5Q Membrane AXW78_09355 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AXW78_09365 ENOG4105CKI cobalamin synthesis protein AXW78_09375 ENOG4105C0Z ABC transporter AXW78_09380 ENOG4108IV0 ABC, transporter AXW78_09385 ENOG4105C32 Amino acid ABC transporter (Permease) AXW78_09395 ENOG4105SKE transcriptional Regulator LysR family AXW78_09415 ENOG4105YGB Transcriptional regulator AXW78_09425 ENOG4105C4M (Ubiquinol oxidase) subunit I AXW78_09430 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AXW78_09435 ENOG4108JJ9 ABC, transporter AXW78_09440 ENOG4108JJ8 (ABC) transporter AXW78_09450 ENOG4105K64 Glycosyl transferase, family 2 AXW78_09460 ENOG4108UT6 Transferase hexapeptide repeat containing protein AXW78_09515 ENOG4105BZ1 (ABC) transporter AXW78_09520 ENOG4105EFI regulatoR AXW78_09525 ENOG4105BZU Histidine kinase AXW78_09535 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AXW78_09540 ENOG4108ZJ4 polysaccharide deacetylase AXW78_09550 ENOG41081VB Hydrolase AXW78_09560 ENOG4105D6E homoserine dehydrogenase AXW78_09570 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AXW78_09585 ENOG4108KGH TRANSCRIPTIONal AXW78_09595 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXW78_09600 ENOG4105BZU Histidine kinase AXW78_09605 ENOG4107VMI polysaccharide deacetylase AXW78_09615 ENOG4105KT7 mgtC SapB transporter AXW78_09620 ENOG4105VRR gCN5-related N-acetyltransferase AXW78_09630 ENOG4105DUU IucA IucC family protein AXW78_09635 ENOG4105CEY Amp-dependent synthetase and ligase AXW78_09650 ENOG4108WBH protein TIM barrel AXW78_09655 ENOG4105YWU small acid-soluble spore protein AXW78_09665 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AXW78_09720 ENOG4105KRN Transcriptional regulator, abrb family AXW78_09730 ENOG4105YVS arsR family transcriptional regulator AXW78_09735 ENOG4105CPC Aldo Keto reductase AXW78_09740 ENOG4107XZQ multidrug resistance protein AXW78_09750 ENOG4105KAF membrAne AXW78_09775 ENOG4105C8Q Methyl-accepting chemotaxis AXW78_09790 ENOG4108K88 Membrane AXW78_09795 ENOG4108WPJ Ferritin-like domain AXW78_09810 ENOG4105DEN Luciferase family AXW78_09825 ENOG4105VMI -acetyltransferase AXW78_09830 ENOG4107QM2 Aldo Keto reductase AXW78_09835 ENOG4105CKI cobalamin synthesis protein AXW78_09845 ENOG4105DSE periplasmic solute binding protein AXW78_09850 ENOG4105K4T epimerase AXW78_09860 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AXW78_09905 ENOG4107T5V SNARE associated Golgi AXW78_09920 ENOG4108PJD permease AXW78_09930 ENOG4108S4H thioesterase Superfamily protein AXW78_09935 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AXW78_09955 ENOG4105SXS Protein of unknown function (DUF456) AXW78_09960 ENOG4105C37 (CBS) domain AXW78_09995 ENOG4108Z7R Chaperone CsaA AXW78_10010 ENOG4108ZRV stage ii sporulation protein p AXW78_10020 ENOG4108VXD carboxy-peptidase AXW78_10050 ENOG4108ZRV stage ii sporulation protein p AXW78_10060 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AXW78_10070 ENOG41087PP glycosyltransferase MGT family AXW78_10075 ENOG4108JYZ YitT family AXW78_10080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AXW78_10110 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AXW78_10140 ENOG4106PAW secretion accessory protein EsaA YueB AXW78_10150 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) AXW78_10155 ENOG4108MGT Required for secretion of EsxA and EsxB AXW78_10250 ENOG4105KBJ sporulation protein ytfj AXW78_10275 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AXW78_10295 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AXW78_10300 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AXW78_10310 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AXW78_10315 ENOG4105EMN RNA polymerase sigma factor AXW78_10330 ENOG4105CNW domain protein AXW78_10340 ENOG4108V06 Glutathione peroxidase AXW78_10355 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AXW78_10365 ENOG4108IUE nitrate reductase beta subunit AXW78_10370 ENOG4105R3A Nitrate reductase AXW78_10380 ENOG4107V6Q Cyclic nucleotide-binding domain AXW78_10385 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AXW78_10390 ENOG4105D06 uba thif-type nad fad binding protein AXW78_10395 ENOG4105CVM Molybdenum cofactor synthesis domain protein AXW78_10400 ENOG4108ZAF Molybdopterin AXW78_10425 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AXW78_10430 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AXW78_10435 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AXW78_10440 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AXW78_10445 ENOG4108IFG nitrite reductase, (NAD(P)H) AXW78_10450 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AXW78_10470 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AXW78_10485 ENOG4105MCT stage V sporulation protein S AXW78_10520 ENOG4105C5H ABC transporter AXW78_10535 ENOG4108UUM single-stranded DNA-binding protein AXW78_10560 ENOG4107YX5 Pfam:DUF548 AXW78_10565 ENOG4105C75 arginyL-tRNA synthetase AXW78_10595 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AXW78_10610 ENOG4105C5S asparaginyl-tRNA synthetase AXW78_10615 ENOG4105C8J )-transporter AXW78_10620 ENOG4108EF6 Proline imino-peptidase AXW78_10635 ENOG4107XGZ Hydrolase AXW78_10640 ENOG4105CY2 Citrate transporter AXW78_10660 ENOG4105KD7 acetyltransferase AXW78_10665 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AXW78_10680 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AXW78_10695 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AXW78_10700 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AXW78_10710 ENOG4107RVG penicillin-binding protein AXW78_10715 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AXW78_10720 ENOG4105E9Q Acyl-transferase AXW78_10725 ENOG4108UT2 hemolysin iii AXW78_10735 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AXW78_10745 ENOG4108RCR degv family AXW78_10755 ENOG4108KF3 Electron transport protein SCO1 SenC AXW78_10760 ENOG4107Y70 Heat shock protein AXW78_10765 ENOG4105CAQ asparagine synthetase AXW78_10780 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AXW78_10785 ENOG4108MES Periplasmic binding protein AXW78_10790 ENOG4105F0I Aminotransferase AXW78_10810 ENOG4107Y70 Heat shock protein AXW78_10815 ENOG4105D8X mechanosensitive ion channel AXW78_10820 ENOG4105BZU Histidine kinase AXW78_10825 ENOG4105WH1 Two component transcriptional regulator luxr family AXW78_10830 ENOG4106KNT transcriptional regulator AXW78_10835 ENOG4107ZY0 Phenazine biosynthesis-like protein AXW78_10855 ENOG4105CMG Carbohydrate kinase AXW78_10860 ENOG4105C6Z Gluconate AXW78_10900 ENOG4108IJ8 ABC transporter AXW78_10905 ENOG4105E90 ABC transporter AXW78_10940 ENOG4105C37 (CBS) domain AXW78_10965 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AXW78_10980 ENOG4107S4Y M20 DapE family protein YgeY AXW78_10985 ENOG4108TSC N-acetyltransferase AXW78_10990 ENOG4108JUB Transcriptional regulator AXW78_10995 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AXW78_11035 ENOG410841Q phosphoesterase PA-phosphatase related protein AXW78_11045 ENOG4105SZ6 Thioredoxin AXW78_11050 ENOG4105KNA -acetyltransferase AXW78_11100 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AXW78_11135 ENOG4105CHR reductase AXW78_11155 ENOG4105BZ4 penicillin-binding protein AXW78_11165 ENOG4105CZM Major Facilitator AXW78_11170 ENOG4105W8X HesB YadR YfhF-family protein AXW78_11180 ENOG4105DXD 2-methylcitrate dehydratase AXW78_11185 ENOG4105CR4 methylisocitrate lyase AXW78_11190 ENOG4105C1G acyl-Coa dehydrogenase AXW78_11195 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AXW78_11205 ENOG4105N14 lysine exporter protein LysE YggA AXW78_11210 ENOG4105E39 Enoyl-CoA hydratase AXW78_11225 ENOG4107RFY SbcCD D subunit AXW78_11230 ENOG4105EYH Exonuclease AXW78_11250 ENOG4105FCD Major Facilitator AXW78_11255 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AXW78_11260 ENOG4105E4F Isochorismate synthase AXW78_11265 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AXW78_11270 ENOG4105WQI isochorismatase AXW78_11275 ENOG4105CEY Amp-dependent synthetase and ligase AXW78_11280 ENOG4105WQT MbtH domain protein AXW78_11285 ENOG4105C0R drug resistance transporter emrb qaca subfamily AXW78_11300 ENOG4105K70 DNA-binding protein AXW78_11320 ENOG4105BZG amino acid carrier protein AXW78_11340 ENOG4105FE9 pseudouridine synthase AXW78_11345 ENOG4105C22 threonyL-tRNA synthetase AXW78_11350 ENOG4105C19 ABC transporter AXW78_11380 ENOG41081I9 integral membrane protein AXW78_11390 ENOG4108Y4K DNA-binding transcriptional activator AXW78_11415 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AXW78_11425 ENOG4105EYF MMPL domain protein AXW78_11450 ENOG4105WCN acetyltransferase AXW78_11475 ENOG4105C1Q protoporphyrinogen oxidase AXW78_11485 ENOG41068WN AXW78_11515 ENOG4107V2S Transcriptional regulator AXW78_11520 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AXW78_11540 ENOG4105DND Transcriptional regulator AXW78_11545 ENOG4108RPX mosc domain containing protein AXW78_11560 ENOG4105BZ1 (ABC) transporter AXW78_11565 ENOG4105BZ1 (ABC) transporter AXW78_11585 ENOG4108JCI Transcriptional regulator AXW78_11620 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AXW78_11625 ENOG4108KPJ rna polymerase sigma factor AXW78_11655 ENOG4105F32 YngK protein AXW78_11675 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AXW78_11680 ENOG4105RD7 BadF BadG BcrA BcrD AXW78_11685 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AXW78_11690 ENOG4107STF Involved in phosphonate degradation (By similarity) AXW78_11695 ENOG4105C7B Threonine dehydratase AXW78_11700 ENOG4108INS Transcriptional regulator AXW78_11715 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AXW78_11720 ENOG4105C1J atp-dependent rna helicase AXW78_11730 ENOG4108RZE Tetr family transcriptional regulator AXW78_11750 ENOG41088CC tellurite resistance protein tehB AXW78_11775 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AXW78_11800 ENOG4105CIN aminoacyl-histidine dipeptidase AXW78_11825 ENOG4105KRN Transcriptional regulator, abrb family AXW78_11835 ENOG4105EJ9 Membrane AXW78_11840 ENOG4105EQK -acetyltransferase AXW78_11875 ENOG4105W8Z 4'-phosphopantetheinyl transferase AXW78_11895 ENOG4105CSV Glutaminase AXW78_11915 ENOG4108Q8B Spore germination protein AXW78_11920 ENOG4108NHD germination protein AXW78_11930 ENOG4105II7 pyrroline-5-carboxylate reductase AXW78_11940 ENOG4105CUB amino acid AXW78_11945 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AXW78_11950 ENOG4105YWU small acid-soluble spore protein AXW78_11955 ENOG41075H3 AraC family transcriptional regulator AXW78_11980 ENOG4105BZU Histidine kinase AXW78_11990 ENOG4108B31 Spore germination protein AXW78_12045 ENOG4108IMY Transcriptional regulator AXW78_12050 ENOG4105BZC d-serine deaminase AXW78_12060 ENOG4107VMI polysaccharide deacetylase AXW78_12075 ENOG4107RVG penicillin-binding protein AXW78_12090 ENOG4107RF6 penicillin-binding protein AXW78_12095 ENOG4107RF6 penicillin-binding protein AXW78_12105 ENOG4105DIN metallophosphoesterase AXW78_12115 ENOG4105CJ1 ABC, transporter AXW78_12125 ENOG4107Z3H Transcriptional regulator, TetR family AXW78_12140 ENOG4105C1G acyl-Coa dehydrogenase AXW78_12145 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AXW78_12150 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AXW78_12155 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AXW78_12160 ENOG4105E39 Enoyl-CoA hydratase AXW78_12165 ENOG4107QX3 carboxylase AXW78_12170 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AXW78_12195 ENOG4105DZ1 carboxypeptidase AXW78_12210 ENOG4105T9C HD domain AXW78_12220 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AXW78_12240 ENOG41075H3 AraC family transcriptional regulator AXW78_12285 ENOG41089UC methyltransferase, type 11 AXW78_12300 ENOG4105MDS 4-oxalocrotonate tautomerase AXW78_12305 ENOG4107V2S Transcriptional regulator AXW78_12330 ENOG4105SX7 Transporter AXW78_12365 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AXW78_12375 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AXW78_12440 ENOG4105D6E homoserine dehydrogenase AXW78_12450 ENOG4105CPF Cell wall formation (By similarity) AXW78_12455 ENOG4105ETU transcriptional activator (TenA AXW78_12475 ENOG4105VTR Integrase AXW78_12510 ENOG4105KRN Transcriptional regulator, abrb family AXW78_12580 ENOG4105CNU cell division protein FtsK AXW78_12630 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AXW78_12785 ENOG410667J hydrolase AXW78_12790 ENOG4105BZU Histidine kinase AXW78_12795 ENOG4107RF6 penicillin-binding protein AXW78_12815 ENOG4108JJB ABC transporter AXW78_12825 ENOG4108HGU Histidine kinase AXW78_12865 ENOG4105CB2 alcohol dehydrogenase AXW78_12870 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AXW78_12875 ENOG4105CJN penicillin-binding protein AXW78_12880 ENOG4108IG5 Transcriptional regulator AXW78_12885 ENOG4105CHR reductase AXW78_12930 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AXW78_12955 ENOG4107Y9U Membrane AXW78_12975 ENOG4105EGD dinuclear metal center protein, YbgI family AXW78_13000 ENOG4105FCD Major Facilitator AXW78_13015 ENOG4105E09 nadh pyrophosphatase AXW78_13020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AXW78_13040 ENOG4108XI2 Domain of unknown function (DUF1963) AXW78_13065 ENOG4108NRW Phospholipase, patatin family AXW78_13070 ENOG4105KWG Pfam:DUF1696 AXW78_13080 ENOG4108YYS metal-dependent hydrolase (By similarity) AXW78_13095 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AXW78_13105 ENOG4105PKS Excinuclease abc c subunit domain protein AXW78_13145 ENOG4107VFR oxidoreductase AXW78_13170 ENOG4105U0R haloacid dehalogenase-like hydrolase AXW78_13175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_13180 ENOG4105BZU Histidine kinase AXW78_13200 ENOG4107WD8 ABC transporter, permease AXW78_13215 ENOG4105DY8 decarboxylase AXW78_13230 ENOG4108IUM Glycogen debranching enzyme AXW78_13240 ENOG4105CGH 5'-nucleotidase AXW78_13255 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AXW78_13260 ENOG4105FDR Membrane AXW78_13265 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AXW78_13315 ENOG4105MSI germination protein ypeb AXW78_13345 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AXW78_13350 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AXW78_13355 ENOG4107Z3H Transcriptional regulator, TetR family AXW78_13370 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AXW78_13385 ENOG4105E98 transcriptional regulator DeoR family AXW78_13400 ENOG41062ES Transcriptional regulator AXW78_13420 ENOG4107QKR Dehydrogenase AXW78_13430 ENOG4107RUY (E1 component), alpha subunit AXW78_13440 ENOG4105E1F short-chain dehydrogenase reductase AXW78_13470 ENOG4107SQ8 Glycine betaine AXW78_13475 ENOG4108IJ7 Glycine betaine AXW78_13500 ENOG4105E66 phosphoriboisomerase A AXW78_13505 ENOG41082BV acetyltransferase AXW78_13510 ENOG4108M1A Chitin-binding protein AXW78_13535 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AXW78_13540 ENOG4105MSB protein, conserved in bacteria AXW78_13565 ENOG4108Z7F N-acetyltransferase AXW78_13590 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AXW78_13610 ENOG4105C9U ATP-dependent DNA helicase RecQ AXW78_13655 ENOG4108M1A Chitin-binding protein AXW78_13670 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AXW78_13680 ENOG4105BZG amino acid carrier protein AXW78_13685 ENOG4105C26 Dehydrogenase AXW78_13690 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AXW78_13695 ENOG4105CTU Proline racemase AXW78_13700 ENOG4105CTU Proline racemase AXW78_13705 ENOG41080HI glycine oxidase AXW78_13715 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein AXW78_13750 ENOG4105DCI Phosphohydrolase AXW78_13755 ENOG4107T5V SNARE associated Golgi AXW78_13765 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AXW78_13780 ENOG4105DTQ mandelate racemase muconate lactonizing AXW78_13795 ENOG4107SET aldo keto reductase AXW78_13830 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AXW78_13835 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AXW78_13840 ENOG4105BZU Histidine kinase AXW78_13845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_13865 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 AXW78_13880 ENOG4105DPN Oligoendopeptidase f AXW78_13885 ENOG4105EPR degv family AXW78_13945 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AXW78_13950 ENOG4106K7D Major facilitator family transporter AXW78_13970 ENOG4107BMA Transglycosylase associated protein AXW78_13985 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AXW78_14010 ENOG4105CHM Aminotransferase AXW78_14065 ENOG4105C02 permease AXW78_14075 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AXW78_14080 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AXW78_14085 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AXW78_14090 ENOG4105D7T ABC transporter AXW78_14115 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AXW78_14155 ENOG4107VC0 DNA alkylation repair enzyme AXW78_14160 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AXW78_14170 ENOG4107VMI polysaccharide deacetylase AXW78_14175 ENOG4108ZCF integral membrane protein AXW78_14180 ENOG4105E0M Sulfatase AXW78_14185 ENOG4105C5H ABC transporter AXW78_14190 ENOG4105EYF MMPL domain protein AXW78_14195 ENOG41082JN Transcriptional regulator AXW78_14215 ENOG4105CIH Imidazole acetol-phosphate transaminase AXW78_14220 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AXW78_14225 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AXW78_14270 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AXW78_14285 ENOG4105EMN RNA polymerase sigma factor AXW78_14310 ENOG4105D4B ABC, transporter AXW78_14315 ENOG4105F5R ABC transporter AXW78_14320 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AXW78_14330 ENOG4105DKT Transcriptional regulator AXW78_14335 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AXW78_14345 ENOG41061GT Aldolase AXW78_14355 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AXW78_14390 ENOG4105II7 pyrroline-5-carboxylate reductase AXW78_14400 ENOG4107258 Transcriptional regulator AXW78_14415 ENOG4105ECK Fatty Acid Desaturase AXW78_14425 ENOG4107RBI VanW family AXW78_14430 ENOG4105G6Z alkaline phosphatase AXW78_14440 ENOG4105VMP Transcriptional regulator AXW78_14470 ENOG41068WN AXW78_14495 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AXW78_14520 ENOG4105CKK Glycosyl transferase, family 2 AXW78_14545 ENOG4105CKK Glycosyl transferase, family 2 AXW78_14555 ENOG4105C8Y Acetylornithine aminotransferase AXW78_14595 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AXW78_14645 ENOG4108IBT Inherit from COG: transposase AXW78_14665 ENOG4108TVJ Nitroreductase AXW78_14670 ENOG4105FS7 Transcriptional regulator AXW78_14690 ENOG4105WEC Molybdate metabolism regulator AXW78_14700 ENOG4105CMR udp-glucose 4-epimerase AXW78_14710 ENOG4108DMH HTH_ARAC AXW78_14715 ENOG4108XET gCN5-related N-acetyltransferase AXW78_14730 ENOG4108PCN EamA-like transporter family AXW78_14775 ENOG410635A Membrane AXW78_14785 ENOG4108IQI permease AXW78_14795 ENOG4105F1N DNA alkylation repair AXW78_14805 ENOG4105BZU Histidine kinase AXW78_14810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_14820 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AXW78_14855 ENOG4107RF6 penicillin-binding protein AXW78_14865 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AXW78_14885 ENOG4105E7W lamb ycsf family protein AXW78_14895 ENOG4105P4J Allophanate hydrolase, subunit 1 AXW78_14900 ENOG4107258 Transcriptional regulator AXW78_14910 ENOG4106N3A copper homeostasis protein cutc AXW78_14915 ENOG4108ZHR arsR family transcriptional regulator AXW78_14925 ENOG4105FDT acyl-CoA dehydrogenase AXW78_14940 ENOG4105DWD nucleoside recognition domain protein AXW78_14970 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AXW78_15035 ENOG4105E2A Dehydrogenase AXW78_15045 ENOG4105CN5 Metallo-Beta-Lactamase AXW78_15055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AXW78_15070 ENOG4105CGH 5'-nucleotidase AXW78_15080 ENOG4105CHJ isochorismatase hydrolase AXW78_15115 ENOG4105F6J Alpha beta hydrolase fold AXW78_15130 ENOG4108606 TspO/MBR family AXW78_15135 ENOG4105CVP deoxyribo-dipyrimidine photolyase AXW78_15170 ENOG4108TWJ NADH dehydrogenase subunit 5 AXW78_15175 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AXW78_15190 ENOG4105E1K spore germination protein AXW78_15200 ENOG4108U7W acetyltransferase AXW78_15205 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AXW78_15210 ENOG4105DSE periplasmic solute binding protein AXW78_15215 ENOG4105CC5 ABC transporter AXW78_15220 ENOG4105DIK (ABC) transporter AXW78_15245 ENOG4105D6J arsenicaL-resistance protein AXW78_15250 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AXW78_15255 ENOG41085FC arsR family transcriptional regulator AXW78_15300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_15305 ENOG41062D9 Histidine kinase AXW78_15335 ENOG4105WH1 Two component transcriptional regulator luxr family AXW78_15355 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AXW78_15360 ENOG4105C0R drug resistance transporter emrb qaca subfamily AXW78_15375 ENOG4105K6H D-cysteine desulfhydrase AXW78_15385 ENOG4105E0Y RtcB Protein AXW78_15395 ENOG4105JQZ Methyltransferase AXW78_15410 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AXW78_15415 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AXW78_15420 ENOG4105BZU Histidine kinase AXW78_15430 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AXW78_15455 ENOG4108JQ1 Dehydrogenase AXW78_15475 ENOG41082W1 Cupin 2, conserved barrel domain protein AXW78_15480 ENOG410874W AraC family transcriptional regulator AXW78_15500 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AXW78_15575 ENOG4108VXD carboxy-peptidase AXW78_15580 ENOG4105PNM synthesis protein AXW78_15590 ENOG4108ISG Major Facilitator AXW78_15605 ENOG4107MII Sugar-specific transcriptional regulator TrmB AXW78_15610 ENOG4105CZM Major Facilitator AXW78_15620 ENOG4105CRW Short chain fatty acid transporter AXW78_15630 ENOG4105DYS nad(p)h dehydrogenase (quinone) AXW78_15690 ENOG4108K8S endonuclease I AXW78_15695 ENOG4108Z66 YbaK ebsC protein AXW78_15700 ENOG4105CUT histidyl-tRNA synthetase AXW78_15715 ENOG4105KVH Transcriptional regulator AXW78_15720 ENOG4108RCM Nitroreductase AXW78_15750 ENOG4108PSK reductase AXW78_15815 ENOG4105C31 Tryptophanyl-tRNA synthetase AXW78_15885 ENOG4105C37 (CBS) domain AXW78_15900 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AXW78_15905 ENOG4105FAW cDP-glucose 4,6-dehydratase AXW78_15935 ENOG4105DDN Pentapeptide repeat-containing protein AXW78_15940 ENOG4105XDF Protein of unknown function (DUF1272) AXW78_15945 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AXW78_15950 ENOG4105CMG Carbohydrate kinase AXW78_15955 ENOG4105C6Z Gluconate AXW78_15960 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AXW78_15975 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AXW78_15980 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AXW78_16000 ENOG4105C8Q Methyl-accepting chemotaxis AXW78_16005 ENOG4108UX3 '-nucleotidase AXW78_16010 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AXW78_16015 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AXW78_16020 ENOG4105KVH Transcriptional regulator AXW78_16030 ENOG41090KN UPF0303 protein AXW78_16040 ENOG4105C44 Serine transporter AXW78_16065 ENOG4108TZY GntR Family Transcriptional Regulator AXW78_16070 ENOG4105D9R oxidoreductase AXW78_16110 ENOG4105JAB phenazine biosynthesis protein, phzf family AXW78_16120 ENOG4108RU0 short-chain dehydrogenase reductase AXW78_16135 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AXW78_16140 ENOG4105KVH Transcriptional regulator AXW78_16145 ENOG4107SCK Monooxygenase AXW78_16165 ENOG4108ZJ4 polysaccharide deacetylase AXW78_16225 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AXW78_16255 ENOG4105H3G oxidoreductase AXW78_16290 ENOG4105CIS alcohol dehydrogenase AXW78_16325 ENOG4108TN2 lmbE family AXW78_16335 ENOG4107R3E Citrate transporter AXW78_16350 ENOG4108MES Periplasmic binding protein AXW78_16355 ENOG4105EHG Permease protein AXW78_16360 ENOG4105DQ5 transport system permease protein AXW78_16365 ENOG4105NX3 Membrane AXW78_16385 ENOG4107CUJ Protein of unknown function (DUF2690) AXW78_16395 ENOG4107V2S Transcriptional regulator AXW78_16420 ENOG4105C98 muts2 protein AXW78_16430 ENOG4105E5K Alpha-amylase AXW78_16435 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AXW78_16440 ENOG4105DPN Oligoendopeptidase f AXW78_16445 ENOG4108A04 Beta-lactamase AXW78_16470 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AXW78_16480 ENOG41082BM Transcriptional regulator, arsr family AXW78_16485 ENOG4105CIS alcohol dehydrogenase AXW78_16520 ENOG4105C09 Bile acid AXW78_16525 ENOG4105CQB FAD linked oxidase domain protein AXW78_16585 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXW78_16655 ENOG4105BZU Histidine kinase AXW78_16660 ENOG4105C5H ABC transporter AXW78_16670 ENOG4107DUR UPF0457 protein AXW78_16690 ENOG4105BZU Histidine kinase AXW78_16700 ENOG4105KT7 mgtC SapB transporter AXW78_16710 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AXW78_16715 ENOG41073R8 VanW family AXW78_16725 ENOG4108R1P AXW78_16740 ENOG4105VEQ Cold shock protein AXW78_16760 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AXW78_16780 ENOG410904N short-chain dehydrogenase reductase AXW78_16790 ENOG4106IQC argininosuccinate lyase AXW78_16805 ENOG4108IA2 Sodium pantothenate symporter AXW78_16815 ENOG4105C26 Dehydrogenase AXW78_16820 ENOG4105CHR reductase AXW78_16830 ENOG4105EWU Squalene--hopene cyclase AXW78_16840 ENOG4105FR1 rard protein AXW78_16845 ENOG410696E Membrane AXW78_16860 ENOG4105D1F ATP-binding protein AXW78_16870 ENOG4108ZAF Molybdopterin AXW78_16875 ENOG4105CVM Molybdenum cofactor synthesis domain protein AXW78_16880 ENOG4105D06 uba thif-type nad fad binding protein AXW78_16885 ENOG4105TMB Formate nitrite transporter AXW78_16895 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AXW78_16900 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AXW78_16910 ENOG4108JB9 formate dehydrogenase AXW78_16915 ENOG4105E1K spore germination protein AXW78_16980 ENOG4107QJT sodium dicarboxylate symporter AXW78_16985 ENOG4108KGH TRANSCRIPTIONal AXW78_16995 ENOG4105EMN RNA polymerase sigma factor AXW78_17005 ENOG4105CIG ABC transporter AXW78_17015 ENOG4105D9R oxidoreductase AXW78_17025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AXW78_17030 ENOG4105K4P CoA-binding domain protein AXW78_17035 ENOG4105C0H protease AXW78_17040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_17050 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AXW78_17055 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AXW78_17060 ENOG4105W8X HesB YadR YfhF-family protein AXW78_17090 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AXW78_17095 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AXW78_17110 ENOG4105BZ1 (ABC) transporter AXW78_17115 ENOG4108I0Z Aconitate hydratase AXW78_17145 ENOG4105E5W Transporter AXW78_17155 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AXW78_17175 ENOG4107F3J Amp-dependent synthetase and ligase AXW78_17180 ENOG4107ZYJ bioY protein AXW78_17185 ENOG4105CEY Amp-dependent synthetase and ligase AXW78_17200 ENOG4108IMY Transcriptional regulator AXW78_17245 ENOG4107AYK membrAne AXW78_17255 ENOG4105BZU Histidine kinase AXW78_17260 ENOG4105FBA Phospholipase Carboxylesterase AXW78_17265 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AXW78_17270 ENOG4105CK7 Sodium proline symporter AXW78_17280 ENOG4105CBC glutamate synthase AXW78_17285 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AXW78_17290 ENOG4108VJ1 Transcriptional regulator (CarD family AXW78_17295 ENOG4108903 Formimidoylglutamase AXW78_17305 ENOG4105CGP Urocanate hydratase AXW78_17320 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AXW78_17350 ENOG4107QIV Cytochrome c biogenesis protein AXW78_17360 ENOG4105CH2 amidohydrolase AXW78_17370 ENOG4105CJ1 ABC, transporter AXW78_17385 ENOG4107RSM transcriptional regulator AXW78_17390 ENOG4105VAW lrga family AXW78_17395 ENOG41067MG lrgb family AXW78_17435 ENOG4105BZ1 (ABC) transporter AXW78_17440 ENOG4105BZ1 (ABC) transporter AXW78_17475 ENOG4108HW3 (ABC) transporter AXW78_17480 ENOG4105CGH 5'-nucleotidase AXW78_17510 ENOG4105K7K Transcriptional regulator AXW78_17525 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AXW78_17530 ENOG4105C5F glutamine synthetase AXW78_17535 ENOG4105KV4 Transcriptional regulator AXW78_17540 ENOG4105CXI aluminum resistance protein AXW78_17545 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AXW78_17550 ENOG4105EN6 Membrane AXW78_17560 ENOG4106F1P AAA ATPase, central domain protein AXW78_17590 ENOG41069ER domain protein AXW78_17595 ENOG4105DM4 PTS System AXW78_17600 ENOG4105DE4 1-phosphofructokinase AXW78_17605 ENOG4105E98 transcriptional regulator DeoR family AXW78_17610 ENOG4107QW4 alcohol dehydrogenase AXW78_17615 ENOG4108SJC Membrane AXW78_17630 ENOG4105C85 amino acid AXW78_17650 ENOG4105TMB Formate nitrite transporter AXW78_17655 ENOG4105K70 DNA-binding protein AXW78_17665 ENOG4105C59 p-type ATPase AXW78_17670 ENOG410681U heavy metal transport detoxification protein AXW78_17675 ENOG4105VPX protein, conserved in bacteria AXW78_17685 ENOG4105NIV Esterase AXW78_17690 ENOG4105E0A ABC, transporter AXW78_17710 ENOG4105CGK Exodeoxyribonuclease III AXW78_17720 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AXW78_17725 ENOG4105D03 DNA-3-methyladenine glycosylase II AXW78_17755 ENOG4105BZU Histidine kinase AXW78_17775 ENOG4105C5E polysaccharide biosynthesis protein AXW78_17805 ENOG4105C8Q Methyl-accepting chemotaxis AXW78_17820 ENOG4105F0V Cell wall hydrolase AXW78_17830 ENOG4105E0M Sulfatase AXW78_17835 ENOG410890F Dynamin family AXW78_17870 ENOG4105DQU oxidoreductase, subunit beta AXW78_17875 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AXW78_17880 ENOG4108IGT Dipeptidase AXW78_17885 ENOG4105MCT stage V sporulation protein S AXW78_17890 ENOG4105D48 metallophosphoesterase AXW78_17910 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AXW78_17925 ENOG4105XZV Protein of unknown function (DUF3243) AXW78_17930 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AXW78_17950 ENOG4105UIB (ABC) transporter AXW78_17955 ENOG4108JQ9 ABC transporter AXW78_17960 ENOG4105DIH basic membrane AXW78_17965 ENOG4105FDP GntR family transcriptional regulator AXW78_17970 ENOG4105CNU cell division protein FtsK AXW78_17980 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AXW78_17990 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AXW78_18000 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AXW78_18005 ENOG4108S0H Dipicolinic acid synthetase, b subunit AXW78_18010 ENOG4105E35 Dipicolinate synthase subunit A AXW78_18020 ENOG4105C1V Peptidase, M16 AXW78_18040 ENOG4105DTN riboflavin biosynthesis protein ribF AXW78_18055 ENOG4105W7A Protein of unknown function (DUF503) AXW78_18065 ENOG4105VHM ribosomal protein AXW78_18070 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AXW78_18075 ENOG4105CHV Transcription elongation factor NusA AXW78_18085 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AXW78_18095 ENOG4105DZP Membrane-associated zinc metalloprotease AXW78_18100 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AXW78_18105 ENOG4105KNE Phosphatidate cytidylyltransferase AXW78_18110 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AXW78_18120 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AXW78_18150 ENOG4108HE4 integrase family AXW78_18160 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AXW78_18165 ENOG4105C79 DNA protecting protein DprA AXW78_18170 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AXW78_18185 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AXW78_18210 ENOG4105VB6 UPF0109 protein AXW78_18230 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AXW78_18235 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AXW78_18250 ENOG4105CHR reductase AXW78_18255 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AXW78_18270 ENOG4105CB5 ATP-dependent DNA helicase recG AXW78_18275 ENOG4105DP4 dak2 domain fusion protein ylov AXW78_18280 ENOG4108ZAA Alkaline-shock protein AXW78_18295 ENOG4105FJ0 thiamine AXW78_18300 ENOG4105DJV ribulose-phosphate 3-epimerase AXW78_18305 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AXW78_18310 ENOG4105D9P serine threonine protein kinase AXW78_18315 ENOG4108ZF3 Phosphatase AXW78_18325 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AXW78_18340 ENOG4105C25 Primosomal protein n' AXW78_18345 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AXW78_18365 ENOG4105DSJ YicC domain protein AXW78_18375 ENOG4105F23 Fibronectin-binding protein AXW78_18385 ENOG4105DC7 peptidase M24 AXW78_18425 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AXW78_18430 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AXW78_18440 ENOG4105CD3 dihydroorotase AXW78_18460 ENOG4105C34 Pseudouridine synthase AXW78_18475 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AXW78_18485 ENOG4105DBK s4 domain protein AXW78_18490 ENOG41067XK integral membrane protein AXW78_18500 ENOG4105DFA alanine racemase domain protein AXW78_18505 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AXW78_18510 ENOG4105WR5 sporulation protein, YlmC YmxH family AXW78_18520 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXW78_18530 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AXW78_18535 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AXW78_18545 ENOG4105D4A Cell wall formation (By similarity) AXW78_18550 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AXW78_18555 ENOG4105CNI cell division protein FtsW AXW78_18570 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AXW78_18575 ENOG4105CJN penicillin-binding protein AXW78_18580 ENOG4105CJN penicillin-binding protein AXW78_18595 ENOG41074B2 UPF0747 protein AXW78_18620 ENOG4105KNH Nucleic acid-binding protein AXW78_18630 ENOG41063PX domain protein AXW78_18635 ENOG4105D78 K07001 NTE family protein AXW78_18640 ENOG4105H20 Sporulation integral membrane protein YlbJ AXW78_18650 ENOG4106H78 methyltransferase AXW78_18670 ENOG4107TB6 phosphoglycerate mutase AXW78_18685 ENOG4106UY4 Inherit from COG: Scp-like extracellular AXW78_18735 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AXW78_18740 ENOG4105CNI cell division protein FtsW AXW78_18755 ENOG4108IAB Phoh family AXW78_18775 ENOG4105QA2 AXW78_18780 ENOG4105CI3 gtp-binding protein typa AXW78_18790 ENOG4105ECY inositol monophosphatase AXW78_18810 ENOG4105CXN decarboxylase AXW78_18860 ENOG4105CPP Dehydrogenase, E1 component AXW78_18875 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AXW78_18880 ENOG4108X4Q Hydrolase AXW78_18890 ENOG4105CN5 Metallo-Beta-Lactamase AXW78_18895 ENOG4107ZYR domain protein AXW78_18930 ENOG4108XRC Protein of unknown function (DUF458) AXW78_18940 ENOG4107IN1 Protein of unknown function (DUF1797) AXW78_18955 ENOG4105EPM Diguanylate phosphodiesterase AXW78_18960 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AXW78_18975 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AXW78_18985 ENOG4105UIN AXW78_19020 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AXW78_19040 ENOG4108HGU Histidine kinase AXW78_19050 ENOG4105CHM Aminotransferase AXW78_19055 ENOG4105FKQ transcriptional regulator AXW78_19060 ENOG4105EG2 ABC transporter, permease AXW78_19070 ENOG4107FKK extracellular solute-binding protein family 1 AXW78_19080 ENOG4105CG3 alpha amylase, catalytic region AXW78_19125 ENOG4105CHU acetyl-coa acetyltransferase AXW78_19155 ENOG4105K7K Transcriptional regulator AXW78_19160 ENOG4105DTD Dehydrogenase AXW78_19180 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AXW78_19220 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AXW78_19230 ENOG4105BZU Histidine kinase AXW78_19250 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AXW78_19265 ENOG4105CID antiterminator AXW78_19275 ENOG4105FDP GntR family transcriptional regulator AXW78_19285 ENOG4105CE4 GlcNAc 6-P deacetylase AXW78_19320 ENOG4107ZE5 PPIases accelerate the folding of proteins AXW78_19325 ENOG4105PTM secreted protein AXW78_19330 ENOG4105J7I hydrolase AXW78_19340 ENOG4105G6R Stage v sporulation protein ae AXW78_19350 ENOG4105CZ3 stage V sporulation protein ad AXW78_19355 ENOG41090VF Stage v sporulation protein ac AXW78_19375 ENOG4105C8J )-transporter AXW78_19380 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXW78_19390 ENOG41082AN stage II sporulation protein AXW78_19395 ENOG4105DZ1 carboxypeptidase AXW78_19400 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AXW78_19405 ENOG4105DVE abc transporter atp-binding protein AXW78_19440 ENOG4105D7N magnesium and cobalt transport protein CorA AXW78_19465 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AXW78_19475 ENOG4105I3K Ferric uptake regulator, Fur family AXW78_19480 ENOG4105MZ9 stage II sporulation protein m AXW78_19500 ENOG4105CPC Aldo Keto reductase AXW78_19510 ENOG4105RHY Pfam:UPF0157 AXW78_19530 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AXW78_19540 ENOG4105ETE Transcriptional regulator (LacI family AXW78_19545 ENOG4108YM7 Gcn5-related n-acetyltransferase AXW78_19565 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AXW78_19570 ENOG4108R6K riboflavin synthase, subunit alpha AXW78_19595 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AXW78_19600 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AXW78_19615 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AXW78_19625 ENOG4105DFD Na H antiporter AXW78_19630 ENOG4105CGH 5'-nucleotidase AXW78_19655 ENOG4105DBV ornithine carbamoyltransferase AXW78_19670 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AXW78_19685 ENOG4108IXY short-chain dehydrogenase reductase AXW78_19690 ENOG41069FQ Metallo-beta-lactamase superfamily AXW78_19695 ENOG4105II7 pyrroline-5-carboxylate reductase AXW78_19700 ENOG4105EJQ L-serine dehydratase AXW78_19715 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AXW78_19740 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AXW78_19745 ENOG4105D9U N-acetyltransferase AXW78_19755 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AXW78_19760 ENOG4108QEG Membrane AXW78_19765 ENOG4105CDA abc transporter atp-binding protein AXW78_19770 ENOG4105E5Q amino acid AbC transporter AXW78_19775 ENOG4108HW3 (ABC) transporter AXW78_19785 ENOG4105G7B Protein of unknown function (DUF2992) AXW78_19795 ENOG4108QY0 Membrane AXW78_19810 ENOG4105C7S Dehydrogenase AXW78_19815 ENOG4105CPP Dehydrogenase, E1 component AXW78_19835 ENOG4107RDP Dehydrogenase AXW78_19850 ENOG4108JUB Transcriptional regulator AXW78_19860 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AXW78_19875 ENOG4107QQR Sporulation AXW78_19880 ENOG4105S1Z Stage IV sporulation protein B AXW78_19885 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AXW78_19895 ENOG4105DX0 Hemolysin A AXW78_19905 ENOG4105CTB Polyprenyl synthetase AXW78_19920 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AXW78_19930 ENOG4108ZSR alkaline shock protein AXW78_19935 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AXW78_19960 ENOG410644B Stage III sporulation protein af AXW78_19970 ENOG4105KQ4 Stage iii sporulation protein ad AXW78_19975 ENOG4108CQH stage III sporulation protein AC AXW78_19980 ENOG4105KR5 Stage iii sporulation protein AXW78_19985 ENOG4105CD2 stage iii sporulation protein aa AXW78_20010 ENOG4105DC7 peptidase M24 AXW78_20025 ENOG4105CBJ Metal-dependent enzyme AXW78_20035 ENOG4107YBY Hydrolase AXW78_20050 ENOG4105K7K Transcriptional regulator AXW78_20065 ENOG41082GG biotin lipoate A B protein ligase AXW78_20070 ENOG4105WZW rhodanese family AXW78_20090 ENOG41080TC multidrug resistance protein AXW78_20125 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AXW78_20155 ENOG4105C0D helicase AXW78_20240 ENOG4107R6U sodium dicarboxylate symporter AXW78_20275 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AXW78_20280 ENOG4105C3R Methionine synthase AXW78_20290 ENOG4105C28 cystathionine AXW78_20295 ENOG4105C28 cystathionine AXW78_20315 ENOG4105C5X domain protein AXW78_20320 ENOG4105DKQ ROK family AXW78_20330 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AXW78_20345 ENOG4108UTW Plays a role in the regulation of phosphate uptake AXW78_20350 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AXW78_20355 ENOG4105C8U phosphate abc transporter AXW78_20360 ENOG4105C8U phosphate abc transporter AXW78_20365 ENOG4105EXS phosphate abc transporter AXW78_20370 ENOG4107RF6 penicillin-binding protein AXW78_20380 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AXW78_20405 ENOG4105N80 Ferric uptake regulator, Fur family AXW78_20415 ENOG4105FDK ABC transporter AXW78_20420 ENOG4108JYZ YitT family AXW78_20425 ENOG41069ZM Protein of unknown function (DUF2624) AXW78_20450 ENOG4105EGD dinuclear metal center protein, YbgI family AXW78_20465 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXW78_20470 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AXW78_20495 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AXW78_20500 ENOG4105KG3 cytidine deaminase AXW78_20505 ENOG4107YR5 Diacylglycerol kinase AXW78_20520 ENOG4105C9A Phoh family AXW78_20530 ENOG41068P3 sporulation protein YqfC AXW78_20540 ENOG4105KTH gatB Yqey AXW78_20550 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AXW78_20555 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AXW78_20575 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AXW78_20585 ENOG4105CSA Coproporphyrinogen iii oxidase AXW78_20590 ENOG4105KVH Transcriptional regulator AXW78_20615 ENOG4105TQK DNA polymerase iii, delta' subunit AXW78_20625 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AXW78_20630 ENOG4108UK2 deaminase AXW78_20635 ENOG4105KQC Competence protein AXW78_20645 ENOG4105DXX methyltransferase AXW78_20655 ENOG4108WF2 Metal Dependent Phosphohydrolase AXW78_20665 ENOG410812S Rna-binding protein AXW78_20675 ENOG4105CQW ribosome biogenesis GTPase YqeH AXW78_20680 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AXW78_20695 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXW78_20715 ENOG4108TVJ Nitroreductase AXW78_20730 ENOG4105G6Z alkaline phosphatase AXW78_20735 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AXW78_20740 ENOG4108MUZ hydrolase AXW78_20775 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AXW78_20780 ENOG4105MIR Phenylalanine 4-monooxygenase AXW78_20790 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AXW78_20830 ENOG4105S6R Iron-hydroxamate transporter permease subunit AXW78_20835 ENOG4108V5C ABC transporter AXW78_20845 ENOG4108EKI Dehydrogenase AXW78_20850 ENOG4105C28 cystathionine AXW78_20880 ENOG4107XRG penicillin-binding protein AXW78_20890 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AXW78_20900 ENOG4105CFP Peptidase U32 AXW78_20905 ENOG4105XYU peptidase (U32 family) AXW78_20910 ENOG4108VQJ O-methyltransferase AXW78_20915 ENOG4105HHA aminodeoxychorismate lyase AXW78_20935 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AXW78_20945 ENOG4105C02 permease AXW78_20960 ENOG41060CR AXW78_20965 ENOG4105C7H Helicase, RecD TraA family AXW78_20975 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AXW78_20980 ENOG4105C3J Cysteine desulfurase AXW78_20990 ENOG4105D1H recombination factor protein RarA AXW78_20995 ENOG4108VCI transcription factor, rsfa family AXW78_21000 ENOG4105CUZ uba thif-type nad fad binding protein AXW78_21010 ENOG4105CUT histidyl-tRNA synthetase AXW78_21025 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AXW78_21030 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AXW78_21040 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AXW78_21045 ENOG41076HS cation diffusion facilitator family transporter AXW78_21050 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AXW78_21060 ENOG4105CKP Polysaccharide Biosynthesis Protein AXW78_21065 ENOG4108QG2 Membrane AXW78_21075 ENOG4105VIE preprotein translocase, subunit YajC AXW78_21090 ENOG41061AI Protein of unknown function (DUF2905) AXW78_21105 ENOG4108HUF Transporter AXW78_21135 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AXW78_21140 ENOG4108IYU L-aspartate oxidase AXW78_21155 ENOG4108RPX mosc domain containing protein AXW78_21165 ENOG4105CQC Prephenate dehydratase AXW78_21185 ENOG4105EWM Histidine kinase AXW78_21210 ENOG4105X36 (ribosomal) protein AXW78_21220 ENOG4105C03 ribonuclease AXW78_21235 ENOG4107QMS site-determining protein AXW78_21250 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AXW78_21255 ENOG4105DFF Rod shape-determining protein mreb AXW78_21290 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AXW78_21480 ENOG4108C33 Resolvase AXW78_21500 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AXW78_21505 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AXW78_21515 ENOG41068KH stage VI sporulation protein D AXW78_21525 ENOG4105D52 delta-aminolevulinic acid dehydratase AXW78_21550 ENOG4105K56 Transcriptional regulator AXW78_21570 ENOG4108IUQ atp-dependent protease AXW78_21595 ENOG4108QCI YvbH-like oligomerisation region AXW78_21615 ENOG4105M59 Phosphodiesterase, mj0936 family AXW78_21630 ENOG4108XJQ germination protein AXW78_21640 ENOG4108PCX Major Facilitator AXW78_21650 ENOG4105KBX Transcriptional regulator, TetR family AXW78_21665 ENOG4105PFC Transcriptional regulator AXW78_21675 ENOG4105DZC cytosine deaminase AXW78_21680 ENOG41067S9 phage shock protein C, PspC AXW78_21685 ENOG4108JCI Transcriptional regulator AXW78_21695 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AXW78_21700 ENOG4108Z40 Transcriptional regulator AXW78_21705 ENOG4105RHA ABC transporter, permease AXW78_21710 ENOG4108IUX (ABC) transporter AXW78_21715 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AXW78_21720 ENOG4105ER2 Ompa motb domain protein AXW78_21725 ENOG4105E14 MotA TolQ exbB proton channel AXW78_21730 ENOG4108VXD carboxy-peptidase AXW78_21740 ENOG4105E33 succinate dehydrogenase AXW78_21750 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AXW78_21760 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AXW78_21765 ENOG4105K63 Thioredoxin AXW78_21770 ENOG4105C10 Electron transfer flavoprotein AXW78_21775 ENOG4105BZJ Electron transfer flavoprotein AXW78_21780 ENOG41060WC Enoyl-CoA hydratase AXW78_21785 ENOG4107Z3H Transcriptional regulator, TetR family AXW78_21790 ENOG4105CEY Amp-dependent synthetase and ligase AXW78_21800 ENOG4105J76 Periplasmic binding protein AXW78_21805 ENOG4105S6R Iron-hydroxamate transporter permease subunit AXW78_21845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXW78_21860 ENOG4105DR4 Methyltransferase AXW78_21875 ENOG4105KFN sortase, SrtB family AXW78_21880 ENOG4105E0A ABC, transporter AXW78_21895 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AXW78_21905 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AXW78_21915 ENOG4105FE9 pseudouridine synthase AXW78_21925 ENOG4105DCG PHP domain protein AXW78_21940 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AXW78_21955 ENOG4105C5S asparaginyl-tRNA synthetase AXW78_21960 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AXW78_21970 ENOG4108RWN rrna methyltransferase AXW78_21995 ENOG4105C0R drug resistance transporter emrb qaca subfamily AXW78_22000 ENOG4105CW7 secretion protein, HlyD family AXW78_22005 ENOG4108JGH Tetr family transcriptional regulator AXW78_22010 ENOG4105CN9 Peptidase m42 family protein AXW78_22030 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AXW78_22035 ENOG4105C22 threonyL-tRNA synthetase AXW78_22040 ENOG4108TDW sporulation protein YtxC AXW78_22060 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AXW78_22065 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AXW78_22070 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AXW78_22080 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AXW78_22085 ENOG4105C2M dna polymerase I AXW78_22090 ENOG4105BZU Histidine kinase AXW78_22095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXW78_22115 ENOG4108HMX isocitrate dehydrogenase (NADP) AXW78_22120 ENOG4105BZN citrate synthase AXW78_22130 ENOG4108REF Sporulation integral membrane protein ytvi AXW78_22135 ENOG4105FS0 cytoplasmic membrane protein AXW78_22160 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AXW78_22165 ENOG4105C6K Malic enzyme AXW78_22170 ENOG4105C0B DNA polymerase III (alpha subunit) AXW78_22175 ENOG4105VV2 AXW78_22185 ENOG4105SFS phosphoesterase RecJ domain protein AXW78_22210 ENOG4105E8R UPF0173 metal-dependent hydrolase AXW78_22215 ENOG4105DC7 peptidase M24 AXW78_22255 ENOG41082W1 Cupin 2, conserved barrel domain protein AXW78_22275 ENOG4107YZX Universal stress protein AXW78_22310 ENOG4108JYZ YitT family AXW78_22330 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AXW78_22340 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AXW78_22345 ENOG4105KBJ sporulation protein ytfj AXW78_22360 ENOG4105EFZ amidohydrolase AXW78_22370 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AXW78_22395 ENOG4105RQF LysR family Transcriptional regulator AXW78_22405 ENOG4105U5Y Transcriptional regulator AXW78_22430 ENOG4108IBT Inherit from COG: transposase AXW78_22470 ENOG4105EMN RNA polymerase sigma factor AXW78_22480 ENOG4108UW5 maltose o-acetyltransferase AXW78_22490 ENOG4105F1V Acetoin utilization protein AXW78_22495 ENOG4105W87 Cbs domain AXW78_22500 ENOG4105DGU Histone deacetylase AXW78_22505 ENOG4106HB6 Alpha beta hydrolase AXW78_22515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXW78_22525 ENOG4107SNB ankyrin repeat protein YahD AXW78_22530 ENOG4105EP9 oxidoreductase AXW78_22535 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AXW78_22560 ENOG4105ETE Transcriptional regulator (LacI family AXW78_22565 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AXW78_22585 ENOG4105C88 aminopeptidase AXW78_22620 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AXW78_22630 ENOG4108VDD TRNA binding domain protein AXW78_22660 ENOG4105C8F Beta-lactamase domain protein AXW78_22675 ENOG4108V15 phosphotransferase enzyme family AXW78_22680 ENOG4108IUM Glycogen debranching enzyme AXW78_22690 ENOG4107QSE Dipeptidase AXW78_22695 ENOG4105YW5 deoR family transcriptional regulator AXW78_22710 ENOG4105CBX hi0933 family AXW78_22745 ENOG4108VJ1 Transcriptional regulator (CarD family AXW78_22750 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AXW78_22755 ENOG4105CSC Glucose uptake protein AXW78_22770 ENOG4108ZAF Molybdopterin AXW78_22775 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AXW78_22780 ENOG4105CVM Molybdenum cofactor synthesis domain protein AXW78_22790 ENOG4105D06 uba thif-type nad fad binding protein AXW78_22795 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AXW78_22820 ENOG41085GJ domain protein AXW78_22830 ENOG4105DWV Homoserine O-trans-acetylase AXW78_22845 ENOG4108B31 Spore germination protein AXW78_22870 ENOG4105C8T Leucyl-tRNA synthetase AXW78_22875 ENOG410605W Major Facilitator AXW78_22880 ENOG4107S91 Sodium hydrogen exchanger AXW78_22885 ENOG4105NCW Trka-c domain protein AXW78_22905 ENOG4105C19 ABC transporter AXW78_22925 ENOG4105N5T Radical SAM Protein AXW78_22955 ENOG4105E8V Alpha Beta Hydrolase Fold protein AXW78_22960 ENOG4108Z0R Transferase AXW78_22965 ENOG4105YVM Phosphoesterase, PA-phosphatase related AXW78_22970 ENOG4105BZF Glycosyl transferase (Group 1 AXW78_22980 ENOG4105EPU Molybdenum cofactor synthesis domain protein AXW78_22990 ENOG4108MK9 spermidine N(1)-acetyltransferase AXW78_23035 ENOG4105BZU Histidine kinase AXW78_23040 ENOG4105BZU Histidine kinase AXW78_23045 ENOG4107S9D Alpha beta hydrolase AXW78_23050 ENOG4107T7U Sulfatase AXW78_23075 ENOG4105D2X ABC transporter substrate-binding protein AXW78_23085 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AXW78_23140 ENOG41080TC multidrug resistance protein AXW78_23145 ENOG410839T multidrug resistance protein AXW78_23165 ENOG4108V2W Carbonate dehydratase AXW78_23170 ENOG4105D7V transposase AXW78_23175 ENOG4105C4M (Ubiquinol oxidase) subunit I AXW78_23180 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AXW78_23215 ENOG41087YS Phage shock protein A AXW78_23245 ENOG4105BZU Histidine kinase AXW78_23250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_23275 ENOG4108UGV hypoxanthine phosphoribosyltransferase AXW78_23280 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AXW78_23295 ENOG4107ZTW SNARE associated Golgi AXW78_23310 ENOG4105C19 ABC transporter AXW78_23315 ENOG41086D8 Transcriptional regulator AXW78_23325 ENOG4105CJ1 ABC, transporter AXW78_23335 ENOG41082BM Transcriptional regulator, arsr family AXW78_23380 ENOG4105C6Z Gluconate AXW78_23385 ENOG4105FDP GntR family transcriptional regulator AXW78_23405 ENOG41069H0 dihydroorotase EC 3.5.2.3 AXW78_23425 ENOG4105DTQ mandelate racemase muconate lactonizing AXW78_23435 ENOG4108IPT Naphthoate synthase AXW78_23440 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AXW78_23445 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AXW78_23450 ENOG4105E4F Isochorismate synthase AXW78_23455 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AXW78_23465 ENOG4105VEQ Cold shock protein AXW78_23515 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AXW78_23610 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AXW78_23645 ENOG4105KT7 mgtC SapB transporter AXW78_23650 ENOG4107PBV potassium channel AXW78_23665 ENOG4105WG9 Conserved Protein AXW78_23675 ENOG4105CHM Aminotransferase AXW78_23680 ENOG4108ZB6 transcriptional regulator AsnC family AXW78_23685 ENOG4105C5I Dehydrogenase AXW78_23690 ENOG4108MUZ hydrolase AXW78_23700 ENOG4105C87 Aminotransferase class I and II AXW78_23715 ENOG4105Y38 Kinase-associated protein B AXW78_23725 ENOG4107R3E Citrate transporter AXW78_23740 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AXW78_23745 ENOG4105KA0 thioesterase Superfamily protein AXW78_23760 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AXW78_23775 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AXW78_23780 ENOG41069ER domain protein AXW78_23795 ENOG4105CEP NADH dehydrogenase AXW78_23825 ENOG4105EWC Purine nucleoside phosphorylase AXW78_23840 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AXW78_23865 ENOG4108JJA ABC, transporter AXW78_23870 ENOG4105C4B ABC transporter, permease AXW78_23875 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AXW78_23905 ENOG41083MR nifu domain-containing protein AXW78_23920 ENOG4108W5N phosphatidylglycerophosphatase a AXW78_23930 ENOG4105DYS nad(p)h dehydrogenase (quinone) AXW78_23935 ENOG4105D4U had-superfamily hydrolase, subfamily iia AXW78_23950 ENOG4105CBT Fructose-1,6-bisphosphatase AXW78_23965 ENOG4105MMD transcriptional regulator AXW78_23970 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AXW78_23975 ENOG4107TXC Transcriptional regulator AXW78_23980 ENOG41090T1 Membrane AXW78_24005 ENOG4105FAA peptidase M23 AXW78_24010 ENOG4108YTE sporulation protein YunB AXW78_24015 ENOG4105KZD Domain of unknown function (DUF1805) AXW78_24020 ENOG4107R8B 5'-nucleotidase AXW78_24030 ENOG4105DIW FeS assembly protein SUFB AXW78_24035 ENOG4108UNV SUF system FeS assembly protein, NifU family AXW78_24040 ENOG4105C9B Cysteine desulfurase AXW78_24045 ENOG4105JRK feS assembly protein SufD AXW78_24050 ENOG4105C3K feS assembly ATPase SufC AXW78_24055 ENOG4105D01 (LipO)protein AXW78_24060 ENOG4105D01 (LipO)protein AXW78_24065 ENOG4108UMI ABC transporter, permease AXW78_24095 ENOG41080E8 Transcriptional regulator, Spx MgsR family AXW78_24115 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AXW78_24130 ENOG4108W8B Beta-lactamase domain protein AXW78_24135 ENOG4105C1G acyl-Coa dehydrogenase AXW78_24140 ENOG4105CHU acetyl-coa acetyltransferase AXW78_24155 ENOG4105DZ1 carboxypeptidase AXW78_24175 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AXW78_24190 ENOG4108SUT Major Facilitator Superfamily AXW78_24195 ENOG4107R7I amino acid AXW78_24210 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AXW78_24220 ENOG4107AYK membrAne AXW78_24255 ENOG4107ZTW SNARE associated Golgi AXW78_24265 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AXW78_24270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_24275 ENOG4105BZU Histidine kinase AXW78_24290 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AXW78_24300 ENOG4105C8Q Methyl-accepting chemotaxis AXW78_24305 ENOG4105C8Q Methyl-accepting chemotaxis AXW78_24310 ENOG4105VG1 fes assembly suf system protein AXW78_24315 ENOG4105D4Y metalloprotease AXW78_24320 ENOG4105C2I pirin domain protein AXW78_24335 ENOG4107S91 Sodium hydrogen exchanger AXW78_24340 ENOG4105NCW Trka-c domain protein AXW78_24350 ENOG4108RMU ferritin dps family protein AXW78_24365 ENOG4108URH decarboxylase AXW78_24375 ENOG41090A1 ferritin AXW78_24380 ENOG4105DHF Membrane AXW78_24385 ENOG4105D9N nucleoside AXW78_24390 ENOG4105D9N nucleoside AXW78_24405 ENOG4108RYK Nad-dependent epimerase dehydratase AXW78_24420 ENOG4105CV8 reductase AXW78_24425 ENOG4105F27 Major Facilitator AXW78_24430 ENOG4105KVH Transcriptional regulator AXW78_24445 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AXW78_24450 ENOG4105D4A Cell wall formation (By similarity) AXW78_24470 ENOG4105WMR Protein CrcB homolog AXW78_24475 ENOG4105WMR Protein CrcB homolog AXW78_24495 ENOG4105C5H ABC transporter AXW78_24500 ENOG4108MK9 spermidine N(1)-acetyltransferase AXW78_24510 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AXW78_24520 ENOG4108W2Y isochorismatase AXW78_24545 ENOG4108IPW abc transporter atp-binding protein AXW78_24550 ENOG4105CM4 permease protein AXW78_24580 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AXW78_24590 ENOG4105XZU Preprotein translocase, subunit SecG AXW78_24595 ENOG41067MG lrgb family AXW78_24615 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AXW78_24645 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXW78_24665 ENOG41090VF Stage v sporulation protein ac AXW78_24670 ENOG4105CZ3 stage V sporulation protein ad AXW78_24685 ENOG4108QY0 Membrane AXW78_24690 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AXW78_24695 ENOG4105KRI phosphocarrier protein (HPr AXW78_24705 ENOG4105CHW UPF0052 protein AXW78_24710 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AXW78_24715 ENOG4108Z4K mutator MutT protein AXW78_24725 ENOG4105C3M thioredoxin reductase AXW78_24735 ENOG4108S4C acetyltransferase AXW78_24755 ENOG41086DT Membrane protein of unknown function AXW78_24765 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AXW78_24785 ENOG4107TXC Transcriptional regulator AXW78_24805 ENOG4105DUM transcriptional regulator, lysR family AXW78_24815 ENOG4108WS4 fmn reductase AXW78_24830 ENOG4105BZ1 (ABC) transporter AXW78_24840 ENOG4105CN1 protease AXW78_24845 ENOG4105CRP Part of the ABC transporter FtsEX involved in AXW78_24850 ENOG4105CAK Cell division ATP-binding protein ftsE AXW78_24860 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AXW78_24870 ENOG4105MS2 ribosomal subunit Interface protein AXW78_24875 ENOG4105VEQ Cold shock protein AXW78_24880 ENOG41081UC Inherit from COG: Competence protein AXW78_24895 ENOG4105KVH Transcriptional regulator AXW78_24905 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AXW78_24910 ENOG4108KGH TRANSCRIPTIONal AXW78_24915 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AXW78_24920 ENOG4105C6Y Udp-glucose 6-dehydrogenase AXW78_24925 ENOG4105ESV Glycosyl transferase, family 4 AXW78_24935 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AXW78_24955 ENOG4105F8D glycoside hydrolase family 4 AXW78_24960 ENOG4105VCP PTS System AXW78_24965 ENOG4105CK1 PTS System AXW78_24975 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AXW78_24985 ENOG4105VCP PTS System AXW78_24995 ENOG4105VZJ PTS System AXW78_25010 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AXW78_25015 ENOG4105ECB domain protein AXW78_25020 ENOG4107RSM transcriptional regulator AXW78_25065 ENOG4105DAA L-lactate AXW78_25075 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AXW78_25085 ENOG4105E0M Sulfatase AXW78_25110 ENOG4107R8N Glycosyl transferase, family 2 AXW78_25120 ENOG4105C94 Transporter AXW78_25125 ENOG41069ER domain protein AXW78_25150 ENOG4105KBK Zinc finger, swim domain protein AXW78_25155 ENOG4105C0D helicase AXW78_25185 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXW78_25195 ENOG4107RBB ABC transporter, permease AXW78_25200 ENOG4105C19 ABC transporter AXW78_25210 ENOG4105CXY transporter AXW78_25230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_25235 ENOG4105CMR udp-glucose 4-epimerase AXW78_25245 ENOG4108KGH TRANSCRIPTIONal AXW78_25255 ENOG4105K64 Glycosyl transferase, family 2 AXW78_25270 ENOG4107T8Q Glycosyl transferase (Group 1 AXW78_25280 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AXW78_25285 ENOG4105CPF Cell wall formation (By similarity) AXW78_25290 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AXW78_25300 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AXW78_25305 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AXW78_25310 ENOG4107YJ4 chain length determinant protein AXW78_25315 ENOG4105HTX biosynthesis protein AXW78_25320 ENOG4107YJ4 chain length determinant protein AXW78_25335 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AXW78_25345 ENOG4105FRN stage II sporulation protein AXW78_25360 ENOG4105DY9 regulatoR AXW78_25380 ENOG4106778 Protein of unknown function (DUF1146) AXW78_25385 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AXW78_25390 ENOG4105C8S subunit m AXW78_25395 ENOG4105D65 subunit l AXW78_25420 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AXW78_25425 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AXW78_25440 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AXW78_25445 ENOG4105BZU Histidine kinase AXW78_25495 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AXW78_25500 ENOG41062M3 atp synthase AXW78_25520 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AXW78_25525 ENOG4108UIC UPF0340 protein AXW78_25530 ENOG4108YZG isomerase AXW78_25545 ENOG4108VGI doxx family AXW78_25550 ENOG4107XC4 flavin reductase domain protein, FMN-binding AXW78_25570 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AXW78_25580 ENOG4108ZXQ stage ii sporulation protein r AXW78_25585 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AXW78_25590 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AXW78_25595 ENOG4107104 thymidine kinase AXW78_25605 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AXW78_25610 ENOG4105CBT Fructose-1,6-bisphosphatase AXW78_25615 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AXW78_25635 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AXW78_25650 ENOG4105C1G acyl-Coa dehydrogenase AXW78_25655 ENOG4105C1G acyl-Coa dehydrogenase AXW78_25660 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AXW78_25670 ENOG4105DF6 Fe-S oxidoreductase AXW78_25685 ENOG4105BZU Histidine kinase AXW78_25700 ENOG4105D4Y metalloprotease AXW78_25710 ENOG4105BZU Histidine kinase AXW78_25715 ENOG4105KCT ABC transporter AXW78_25720 ENOG4108M15 ABC transporter AXW78_25725 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AXW78_25735 ENOG4105IIU Aminopeptidase AXW78_25755 ENOG4105JVQ RNA Polymerase AXW78_25765 ENOG410684U Domain of unknown function (DUF1934) AXW78_25785 ENOG4105CYW agmatinase AXW78_25795 ENOG4105DXB Major Facilitator superfamily AXW78_25800 ENOG4107SWG transcriptional regulator MERR family AXW78_25805 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AXW78_25810 ENOG4105BZ4 penicillin-binding protein AXW78_25815 ENOG4108XFG YwhD family AXW78_25820 ENOG4108Z4T Peptidase M50 AXW78_25825 ENOG41069HH 4-oxalocrotonate tautomerase AXW78_25830 ENOG4105DCI Phosphohydrolase AXW78_25835 ENOG4108MES Periplasmic binding protein AXW78_25840 ENOG4105E0A ABC, transporter AXW78_25845 ENOG4105EHG Permease protein AXW78_25850 ENOG4105DQ5 transport system permease protein AXW78_25860 ENOG4108VCI transcription factor, rsfa family AXW78_25865 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AXW78_25870 ENOG4108IJ2 phosphate acetyltransferase AXW78_25875 ENOG4107UEZ chlorite dismutase AXW78_25885 ENOG4108VKI Cell wall hydrolase AXW78_25905 ENOG4107SVH Potassium channel protein AXW78_25915 ENOG410667J hydrolase AXW78_25920 ENOG4105VCH membrane AXW78_25930 ENOG4108TU7 Inherit from COG: (ABC) transporter AXW78_25935 ENOG4105CJ1 ABC, transporter AXW78_25940 ENOG41090WU lipolytic protein G-D-S-L family AXW78_25955 ENOG4105D6E homoserine dehydrogenase AXW78_25960 ENOG4105CVG Homoserine O-transsuccinylase AXW78_25975 ENOG4108Y4K DNA-binding transcriptional activator AXW78_25985 ENOG4105WH1 Two component transcriptional regulator luxr family AXW78_25990 ENOG4105BZU Histidine kinase AXW78_25995 ENOG4105DWF phosphomethylpyrimidine kinase AXW78_26000 ENOG4105BZU Histidine kinase AXW78_26005 ENOG4105VCD cytoplasmic protein AXW78_26010 ENOG4105D22 carbon starvation protein AXW78_26015 ENOG4105DY9 regulatoR AXW78_26020 ENOG41079KZ Major Facilitator Superfamily AXW78_26030 ENOG4105CG5 Glycosyl transferase (Group 1 AXW78_26040 ENOG4105EN6 Membrane AXW78_26045 ENOG4106YBV Methyl-accepting chemotaxis AXW78_26055 ENOG4108S4H thioesterase Superfamily protein AXW78_26060 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AXW78_26075 ENOG4105K64 Glycosyl transferase, family 2 AXW78_26085 ENOG4105EJV Membrane AXW78_26090 ENOG4105CKK Glycosyl transferase, family 2 AXW78_26095 ENOG4105C5H ABC transporter AXW78_26100 ENOG41067SE Tetr family transcriptional regulator AXW78_26110 ENOG4105E0X reductase AXW78_26115 ENOG4106F5Q Membrane AXW78_26130 ENOG4108NEV two component transcriptional regulator, LytTR family AXW78_26135 ENOG4108HRK Histidine kinase AXW78_26140 ENOG4107RGD Major Facilitator superfamily AXW78_26155 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AXW78_26165 ENOG4105IW1 AmiS UreI transporter AXW78_26170 ENOG4105CMR udp-glucose 4-epimerase AXW78_26175 ENOG4108UT2 hemolysin iii AXW78_26185 ENOG4105C1J atp-dependent rna helicase AXW78_26190 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) AXW78_26225 ENOG4105C0H protease AXW78_26230 ENOG4105Q2H domain protein AXW78_26245 ENOG4105BZU Histidine kinase AXW78_26250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_26275 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AXW78_26280 ENOG4105CDU Replicative dna helicase AXW78_26290 ENOG4105BZR domain protein AXW78_26295 ENOG4108XMW Membrane AXW78_26305 ENOG4108UUM single-stranded DNA-binding protein AXW78_26315 ENOG4105C3G gtp-binding protein AXW78_26320 ENOG4105VDK protein, conserved in bacteria AXW78_26325 ENOG4105D8X mechanosensitive ion channel AXW78_26330 ENOG4108ZDA Sporulation protein YyaC AXW78_26335 ENOG4105FA0 parb-like partition protein AXW78_26340 ENOG4107QJE Chromosome Partitioning Protein AXW78_26355 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AXW78_26360 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AXW78_26370 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AXW78_26395 ENOG4105C0W non-ribosomal peptide synthetase AXW78_26420 ENOG4105CJ1 ABC, transporter AXW78_26425 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AXW78_26455 ENOG4105C8Q Methyl-accepting chemotaxis AXW78_26485 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AXW78_26505 ENOG4105DQ6 Transposase AXW78_26515 ENOG41067FT ParB-like nuclease domain AXW78_26545 ENOG4105TRI Hydrolase AXW78_26585 ENOG4105IBP Cyclic peptide transporter AXW78_26590 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AXW78_26595 ENOG4105C0W non-ribosomal peptide synthetase AXW78_26610 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) AXW78_26615 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AXW78_26630 ENOG4105C1G acyl-Coa dehydrogenase AXW78_26670 ENOG4105CKK Glycosyl transferase, family 2 AXW78_26695 ENOG4107SET aldo keto reductase AXW78_26715 ENOG4105D7V transposase AXW78_26735 ENOG4105D2T synthase AXW78_26750 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AXW78_26755 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AXW78_26760 ENOG4105C1B dTDP-glucose 4-6-dehydratase AXW78_26765 ENOG4105C5E polysaccharide biosynthesis protein AXW78_26780 ENOG4105CHR reductase AXW78_26795 ENOG4105D2T synthase AXW78_26800 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AXW78_26825 ENOG4108IMY Transcriptional regulator AXW78_26850 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AXW78_26855 ENOG4108UT6 Transferase hexapeptide repeat containing protein AXW78_26865 ENOG4105K64 Glycosyl transferase, family 2 AXW78_26870 ENOG4105E39 Enoyl-CoA hydratase AXW78_26885 ENOG4105CFF transcriptional regulator AXW78_26920 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AXW78_26930 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AXW78_26960 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AXW78_26980 ENOG4105DQ6 Transposase AXW78_27030 ENOG4105K70 DNA-binding protein AXW78_27070 ENOG4105CAQ asparagine synthetase AXW78_27075 ENOG4108RZE Tetr family transcriptional regulator AXW78_27080 ENOG4107VMI polysaccharide deacetylase AXW78_27095 ENOG4108IMY Transcriptional regulator AXW78_27140 ENOG4108IBT Inherit from COG: transposase AXW78_27210 ENOG4105D7V transposase AXW78_27215 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AXW78_27230 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AXW78_27235 ENOG4105DR5 peptidase AXW78_27240 ENOG41065S2 pneumococcal vaccine antigen AXW78_27270 ENOG4108SHJ s-layer protein AXW78_27275 ENOG4107U9B transcriptional regulator AXW78_27280 ENOG4108UMN azlc family AXW78_27285 ENOG4105KMT branched-chain amino acid AXW78_27310 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AXW78_27315 ENOG4108V2W Carbonate dehydratase AXW78_27345 ENOG4105D7V transposase AXW78_27350 ENOG4105E4C Lytic transglycosylase catalytic AXW78_27360 ENOG41069ER domain protein AXW78_27370 ENOG4107JM4 Tetratricopeptide repeat AXW78_27480 ENOG4105D7V transposase AXW78_27520 ENOG4105EKQ RNA-directed DNA polymerase AXW78_27530 ENOG4105EKQ RNA-directed DNA polymerase AXW78_27535 ENOG4105EKQ RNA-directed DNA polymerase AXW78_27635 ENOG4105DQ6 Transposase AXW78_27655 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AXW78_27660 ENOG4105CZV ABC transporter AXW78_27695 ENOG4108VJ1 Transcriptional regulator (CarD family AXW78_27730 ENOG4105DHF Membrane AXW78_27810 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AXW78_27815 ENOG4107TXC Transcriptional regulator AXW78_27825 ENOG4105KNA -acetyltransferase AXW78_27830 ENOG41087PP glycosyltransferase MGT family AXW78_27835 ENOG4108WC5 Alpha Beta Hydrolase Fold protein AXW78_27840 ENOG4108WC5 Alpha Beta Hydrolase Fold protein AXW78_27860 ENOG4105D7V transposase AXW78_27895 ENOG4108R5S membrane AXW78_27900 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AXW78_27905 ENOG41069DP small acid-soluble spore protein AXW78_27910 ENOG4108QY0 Membrane AXW78_27935 ENOG4108KS4 Spore coat protein AXW78_27940 ENOG4107SBE Glycosyl transferase (Group 1 AXW78_27960 ENOG4107SBE Glycosyl transferase (Group 1 AXW78_27965 ENOG4108IAJ Nad-dependent epimerase dehydratase AXW78_28095 ENOG4107TVC Glycosyl transferase, family 2 AXW78_28120 ENOG4105DUX Transporter AXW78_28130 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AXW78_28150 ENOG410829K Lysine exporter protein (Lyse ygga) AXW78_28210 ENOG41087PP glycosyltransferase MGT family AXW78_28220 ENOG4105ED2 Beta-lactamase AXW78_28255 ENOG4105DHF Membrane AXW78_28270 ENOG4105C19 ABC transporter AXW78_28330 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AXW78_28350 ENOG4105DRR Transcriptional regulator, GntR family AXW78_28365 ENOG4105DQ6 Transposase AXW78_28410 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AXW78_28415 ENOG4105CZV ABC transporter AXW78_28440 ENOG4105DVH amino acid AXW78_28455 ENOG4105EJQ L-serine dehydratase AXW78_28460 ENOG4105C44 Serine transporter AXW78_28470 ENOG4108JGH Tetr family transcriptional regulator AXW78_28475 ENOG4105EQ0 Major Facilitator superfamily AXW78_28480 ENOG4105MZU cell filamentation protein AXW78_28495 ENOG4107QJQ Mate efflux family protein AXW78_28515 ENOG4107QTZ amino acid AXW78_28540 ENOG4107QHE Choloylglycine hydrolase AXW78_28545 ENOG4105FQP Beta-lactamase AXW78_28550 ENOG4105CNI cell division protein FtsW AXW78_28555 ENOG4105CJW magnesium transporter AXW78_28565 ENOG4105F27 Major Facilitator AXW78_28570 ENOG4105GZI Transcriptional regulator AXW78_28585 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AXW78_28605 ENOG4108E1C hydrolase AXW78_28660 ENOG4108JPW Aminotransferase AXW78_28670 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AXW78_28675 ENOG4105CP9 extracellular ligand-binding receptor AXW78_28685 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AXW78_28705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXW78_28715 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AXW78_28735 ENOG4107TPS domain protein AXW78_28740 ENOG4105CEP NADH dehydrogenase AXW78_28755 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C AXW78_28760 ENOG4108M1A Chitin-binding protein AXW78_28770 ENOG4105E1K spore germination protein AXW78_28855 ENOG4105D78 K07001 NTE family protein AXW78_28860 ENOG41063PX domain protein AXW78_28880 ENOG4105FDK ABC transporter AXW78_28885 ENOG4105W8Z 4'-phosphopantetheinyl transferase AXW78_28995 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AXW78_29155 ENOG4107QJE Chromosome Partitioning Protein AXW78_29170 ENOG4108IMY Transcriptional regulator AXW78_29195 ENOG4105XB7 anti-repressor protein AXW78_29215 ENOG4108NF7 phage-type endonuclease AXW78_29220 ENOG4108PNI recT protein AXW78_29280 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AXW78_29325 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AXW78_29390 ENOG410907Z n-acetylmuramoyl-l-alanine amidase AXW78_29520 ENOG4108N0N Phage Terminase Large Subunit AXW78_29545 ENOG4107QZI cell division protein FtsK AXW78_29560 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AXW78_29690 ENOG4107QJE Chromosome Partitioning Protein AXW78_29730 ENOG41067QW Transcriptional regulator AXW78_29780 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AXW78_29920 ENOG4105XSJ toxin secretion phage lysis holin AXW78_30005 ENOG4105W8Z 4'-phosphopantetheinyl transferase AXW78_30055 ENOG4105F0V Cell wall hydrolase AXW78_30125 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AXW78_30185 ENOG4105D7V transposase AXW78_30195 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AXW78_30330 ENOG4105DQ6 Transposase AXW78_30345 ENOG4105DQ6 Transposase AXW78_30360 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AXW78_30365 ENOG4105IEH endo-beta-N-acetylglucosaminidase AXW78_30390 ENOG4105CJW magnesium transporter AXW78_30405 ENOG4105D7V transposase AXW78_30415 ENOG4105D7V transposase AXW78_30425 ENOG4105DQ6 Transposase AXW78_30435 ENOG4105EKQ RNA-directed DNA polymerase AXW78_30475 ENOG4105DQ6 Transposase AXW78_30535 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AXW78_30540 ENOG4105D7V transposase AXW78_30590 ENOG4108JJA ABC, transporter AXW78_30595 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AXW78_30605 ENOG4105CZV ABC transporter AXW78_30675 ENOG4105EKQ RNA-directed DNA polymerase AXW78_30715 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) AXW78_30720 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) AXW78_30740 ENOG4105FB9 CRISPR-associated protein AXW78_30780 ENOG4105D7V transposase AXW78_30835 ENOG4105XFA sporulation peptidase YabG AXW78_30880 ENOG4105CK5 oxidoreductase AXW78_30885 ENOG4105CK5 oxidoreductase AXW78_30915 ENOG4105EKQ RNA-directed DNA polymerase AXW78_31195 ENOG4105DHF Membrane AXW78_31220 ENOG4105DQ6 Transposase AXW78_31260 ENOG4105EKQ RNA-directed DNA polymerase AXW78_31275 ENOG4105K70 DNA-binding protein AXW78_31285 ENOG4105KRN Transcriptional regulator, abrb family AXW78_31295 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)