locus-tag class description BTB_502p00040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTB_502p00060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTB_502p00080 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BTB_502p00100 ENOG4108UUM single-stranded DNA-binding protein BTB_502p00390 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BTB_502p00680 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) BTB_502p01220 ENOG4107104 thymidine kinase BTB_502p01440 ENOG4105MUA Resistance protein BTB_502p01460 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BTB_502p01490 ENOG4105C7H Helicase, RecD TraA family BTB_502p01930 ENOG4105C3F Signal peptidase i BTB_502p02940 ENOG4107TS3 membrane protein, TerC BTB_502p03090 ENOG4105EQI Metal Dependent Phosphohydrolase BTB_502p03290 ENOG410906U SprT-like BTB_502p03300 ENOG410906U SprT-like BTB_502p03510 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTB_502p03980 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BTB_502p04050 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BTB_502p04070 ENOG4105K46 50S ribosomal protein l27 BTB_502p04080 ENOG4105X36 (ribosomal) protein BTB_502p04330 ENOG41065RQ ADP-ribosylation crystallin J1 BTB_502p04560 ENOG410906U SprT-like BTB_502p04750 ENOG4106FN3 tellurium resistance protein BTB_502p05060 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTB_502p05130 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BTB_502p05190 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BTB_502p05420 ENOG4105BZ4 penicillin-binding protein BTB_502p06050 ENOG4105CUB amino acid BTB_502p06060 ENOG4105CB5 ATP-dependent DNA helicase recG BTB_502p06140 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BTB_502p06160 ENOG4105CPI Metal Dependent Phosphohydrolase BTB_502p06270 ENOG4108R1E Serine threonine protein phosphatase 1 BTB_502p06290 ENOG4105C0B DNA polymerase III (alpha subunit) BTB_502p06360 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BTB_502p06430 ENOG41069ER domain protein BTB_502p06520 ENOG4107TT5 NLP P60 protein BTB_502p06610 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BTB_502p06650 ENOG4105VXP Protein of unknown function DUF86 BTB_502p06960 ENOG4105E0Y RtcB Protein BTB_502p07030 ENOG4105MZU cell filamentation protein BTB_502p07110 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BTB_502p07220 ENOG4105C7H Helicase, RecD TraA family BTB_502p07240 ENOG4107YTP response regulator receiver protein BTB_502p07260 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BTB_502p07290 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BTB_502p07360 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BTB_502p07400 ENOG4105ZU5 s-layer protein BTB_502p07410 ENOG4108UVJ appr-1-p processing domain protein BTB_502p07440 ENOG4105NI8 Cytosine-specific methyltransferase BTB_502p07520 ENOG4105CZX twitching motility protein BTB_502p07600 ENOG4105K70 DNA-binding protein BTB_502p07630 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTB_502p07650 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_78p00140 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTB_78p00200 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTB_78p00560 ENOG4105K4H Nlp p60 protein BTB_78p00630 ENOG4105EKQ RNA-directed DNA polymerase BTB_78p00690 ENOG4108FPN Integrase BTB_78p00700 ENOG4108KU9 integrase family BTB_7p00070 ENOG41086VY Fic/DOC family BTB_8p00030 ENOG4107QYX exodeoxyribonuclease v alpha BTB_c00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BTB_c00030 ENOG410848D S4 domain protein YaaA BTB_c00060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTB_c00130 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BTB_c00200 ENOG4105ZMH deoxynucleoside kinase BTB_c00220 ENOG4105GTG Isochorismatase BTB_c00230 ENOG4108Z6B deaminase BTB_c00240 ENOG4105C6E dna polymerase iii BTB_c00280 ENOG41067KS pro-sigma K processing BTB_c00350 ENOG4105CXN decarboxylase BTB_c00370 ENOG4105FA2 dna polymerase iii BTB_c00380 ENOG4105MA4 psp1 domain protein BTB_c00400 ENOG41060K3 Methyltransferase BTB_c00420 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BTB_c00430 ENOG4105KRN Transcriptional regulator, abrb family BTB_c00440 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BTB_c00450 ENOG4105F8V Hydrolase, tatD family BTB_c00460 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BTB_c00480 ENOG4105XFA sporulation peptidase YabG BTB_c00490 ENOG4105W42 Veg protein BTB_c00520 ENOG4105DFT pur operon repressor BTB_c00530 ENOG4105KME endoribonuclease L-psp BTB_c00560 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BTB_c00570 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BTB_c00590 ENOG4108JA2 transcriptioN-repair coupling factor BTB_c00600 ENOG4108M14 stage v sporulation protein t BTB_c00620 ENOG4108IY2 MazG family BTB_c00630 ENOG41082I2 s4 domain protein BTB_c00640 ENOG4105VYY sporulation protein yabp BTB_c00670 ENOG41060GV RNA binding s1 domain protein BTB_c00710 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BTB_c00720 ENOG4108UGV hypoxanthine phosphoribosyltransferase BTB_c00730 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BTB_c00760 ENOG4105C6T cysteine synthase BTB_c00770 ENOG4105CRQ synthase (Component I) BTB_c00780 ENOG4105DDQ anthranilate synthase BTB_c00790 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BTB_c00800 ENOG4105EEI dihydropteroate synthase BTB_c00810 ENOG4105KRF dihydroneopterin aldolase BTB_c00820 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BTB_c00840 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BTB_c01020 ENOG4108Z0C Uvrb UvrC protein BTB_c01050 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BTB_c01070 ENOG4105CTP PilT protein domain protein BTB_c01110 ENOG4105D7W serine acetyltransferase BTB_c01140 ENOG4105C2N RNA methyltransferase TrmH family group 3 BTB_c01150 ENOG4105M0M Tetracycline resistance protein BTB_c01160 ENOG4105QIV RNA polymerase BTB_c01180 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BTB_c01220 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BTB_c01230 ENOG4107Y49 methyltransferase BTB_c01250 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BTB_c01260 ENOG4105XPM ribosomal protein BTB_c01470 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BTB_c01520 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BTB_c01540 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BTB_c01560 ENOG41067V7 50S ribosomal protein L36 BTB_c01610 ENOG4108JJB ABC transporter BTB_c01620 ENOG4108JJB ABC transporter BTB_c01630 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BTB_c01640 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BTB_c01690 ENOG4105D1F ATP-binding protein BTB_c01720 ENOG4108NMV polysaccharide deacetylase BTB_c01880 ENOG4105C8B TIGR00159 family BTB_c01890 ENOG4107U5W ybbr family BTB_c01910 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BTB_c01970 ENOG4108PSK reductase BTB_c01980 ENOG4108UMI ABC transporter, permease BTB_c01990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTB_c02000 ENOG4105D01 (LipO)protein BTB_c02010 ENOG4105CB2 alcohol dehydrogenase BTB_c02030 ENOG4105IQ5 FAD linked oxidase domain protein BTB_c02060 ENOG4105C2C drug resistance transporter, Bcr CflA BTB_c02100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTB_c02110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTB_c02120 ENOG4105C3U ABC transporter BTB_c02130 ENOG4108JQ7 (ABC) transporter BTB_c02170 ENOG4108J59 Extracellular solute-binding protein, family 5 BTB_c02180 ENOG4108J59 Extracellular solute-binding protein, family 5 BTB_c02230 ENOG4105E0C molybdate abc transporter BTB_c02240 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BTB_c02250 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BTB_c02280 ENOG4105EGI Transcriptional regulator BTB_c02320 ENOG4105F6E Acyl-transferase BTB_c02360 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BTB_c02400 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BTB_c02440 ENOG4105C5H ABC transporter BTB_c02460 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BTB_c02480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTB_c02490 ENOG4105C3U ABC transporter BTB_c02500 ENOG4108JQ7 (ABC) transporter BTB_c02510 ENOG410667J hydrolase BTB_c02550 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BTB_c02560 ENOG4105ERH Fumarylacetoacetate hydrolase BTB_c02580 ENOG4105CUB amino acid BTB_c02590 ENOG4108SC4 )-transporter BTB_c02600 ENOG4105CPF Cell wall formation (By similarity) BTB_c02610 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BTB_c02660 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BTB_c02670 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BTB_c02690 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BTB_c02890 ENOG4105K8N protein family UPF0079, ATPase BTB_c02900 ENOG41072GX Peptidase M22 Glycoprotease BTB_c02910 ENOG410801F ribosomal-protein-alanine acetyltransferase BTB_c02920 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BTB_c02930 ENOG4105C5H ABC transporter BTB_c02960 ENOG4108TYN CAAX amino terminal protease family protein BTB_c03000 ENOG4107EV6 Inherit from COG: YD repeat protein BTB_c03030 ENOG4105C7N Xanthine uracil vitamin C permease BTB_c03050 ENOG4105BZU Histidine kinase BTB_c03100 ENOG4107ZXU DSBA oxidoreductase BTB_c03140 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTB_c03260 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BTB_c03320 ENOG4105SX7 Transporter BTB_c03370 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BTB_c03380 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BTB_c03390 ENOG4105C83 adenylosuccinate lyase BTB_c03410 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BTB_c03460 ENOG4108V3E phosphoribosylglycinamide formyltransferase BTB_c03480 ENOG4105C12 Phosphoribosylglycinamide synthetase BTB_c03500 ENOG4105EGI Transcriptional regulator BTB_c03550 ENOG4105C4R Atp-dependent dna helicase BTB_c03560 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BTB_c03600 ENOG4108W2Y isochorismatase BTB_c03610 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTB_c03620 ENOG4108UMI ABC transporter, permease BTB_c03630 ENOG4105D01 (LipO)protein BTB_c03660 ENOG410834F Transcriptional regulator BTB_c03670 ENOG4107I77 yiaA/B two helix domain BTB_c03710 ENOG4105CBD Diacylglycerol kinase BTB_c03730 ENOG4108JPW Aminotransferase BTB_c03750 ENOG4105C26 Dehydrogenase BTB_c03760 ENOG4105KPY Small multidrug resistance protein BTB_c03820 ENOG4105D9N nucleoside BTB_c03830 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BTB_c03850 ENOG4108W15 Protein of unknown function (DUF1456) BTB_c03880 ENOG4105DTQ mandelate racemase muconate lactonizing BTB_c03900 ENOG4105DFD Na H antiporter BTB_c03950 ENOG4105D3R alkyl hydroperoxide reductase BTB_c03960 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BTB_c03970 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BTB_c03980 ENOG4107W7X Aldolase BTB_c03990 ENOG4105EHG Permease protein BTB_c04000 ENOG4105DQ5 transport system permease protein BTB_c04010 ENOG4108V5C ABC transporter BTB_c04020 ENOG4105CAY ferredoxin--nadp reductase BTB_c04050 ENOG4106UIA BTB_c04060 ENOG4106UIA BTB_c04090 ENOG4105BZU Histidine kinase BTB_c04130 ENOG410756H nucleotidyltransferase BTB_c04140 ENOG4105D2S major facilitator superfamily BTB_c04170 ENOG4105E5Q amino acid AbC transporter BTB_c04180 ENOG4105EAB amino acid AbC transporter BTB_c04200 ENOG4105C8Q Methyl-accepting chemotaxis BTB_c04230 ENOG4105DBV ornithine carbamoyltransferase BTB_c04250 ENOG4105C5B carbamate kinase BTB_c04260 ENOG4108W63 CRP FNR family transcriptional regulator BTB_c04280 ENOG4105DNP FAD linked oxidase domain protein BTB_c04300 ENOG4105CI1 PTS System BTB_c04330 ENOG4105C9U ATP-dependent DNA helicase RecQ BTB_c04360 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BTB_c04400 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BTB_c04410 ENOG4105D2X ABC transporter substrate-binding protein BTB_c04430 ENOG4105C5H ABC transporter BTB_c04500 ENOG41062JF Transcriptional regulator BTB_c04530 ENOG4105DEU major facilitator superfamily BTB_c04560 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BTB_c04590 ENOG4108N0M stress protein BTB_c04600 ENOG4106FN3 tellurium resistance protein BTB_c04610 ENOG4106FN3 tellurium resistance protein BTB_c04620 ENOG4107TS3 membrane protein, TerC BTB_c04630 ENOG4108TTB tellurium resistance protein BTB_c04660 ENOG41068PA UPF0435 protein BTB_c04670 ENOG4105KJF protein tyrosine phosphatase BTB_c04690 ENOG4107U9T Pfam:Ribonuclease_BN BTB_c04700 ENOG4105C59 p-type ATPase BTB_c04710 ENOG4108IPJ Membrane BTB_c04750 ENOG4107ZTW SNARE associated Golgi BTB_c04780 ENOG410606W general stress protein BTB_c04790 ENOG4105UPD Calcium Proton BTB_c04860 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BTB_c04870 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BTB_c04890 ENOG4108JUB Transcriptional regulator BTB_c04910 ENOG4108IQI permease BTB_c04980 ENOG4108A04 Beta-lactamase BTB_c05010 ENOG4107R51 Glycosyl transferase, family 2 BTB_c05020 ENOG4107QQG Dehydrogenase BTB_c05030 ENOG4105C3I Nad-dependent epimerase dehydratase BTB_c05040 ENOG4105CKK Glycosyl transferase, family 2 BTB_c05060 ENOG4105F1A Pyruvate formate-lyase BTB_c05100 ENOG4105CI2 imidazolone-5-propionate hydrolase BTB_c05110 ENOG4105ECP epimerase BTB_c05170 ENOG41067AE Membrane-bound metal-dependent hydrolase BTB_c05180 ENOG4105CEN a g-specific adenine glycosylase BTB_c05190 ENOG4106BXE BTB_c05230 ENOG4105BZ1 (ABC) transporter BTB_c05240 ENOG4107NBY Membrane BTB_c05250 ENOG4105CBC glutamate synthase BTB_c05270 ENOG4108IUW ABC transporter BTB_c05310 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTB_c05320 ENOG4105G5W regulator Fur family BTB_c05560 ENOG4108JQC penicillin-binding protein 1A BTB_c05570 ENOG4108R9S DSBA oxidoreductase BTB_c05590 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BTB_c05610 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BTB_c05620 ENOG4105BZU Histidine kinase BTB_c05640 ENOG4105CYN Serine protein kinase BTB_c05680 ENOG4105C94 Transporter BTB_c05710 ENOG4105DZ6 Band 7 protein BTB_c05730 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BTB_c05740 ENOG4108V9W transcriptional regulatory protein BTB_c05750 ENOG4105D4T Citrate transporter BTB_c05800 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BTB_c05810 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTB_c05820 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BTB_c05830 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BTB_c05840 ENOG4105BZ7 extracellular solute-binding protein family 1 BTB_c05850 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BTB_c05860 ENOG4108STX response regulator BTB_c05870 ENOG4105US7 Histidine kinase BTB_c05920 ENOG4108MRH transcriptional regulatory protein BTB_c05940 ENOG4105C6K Malic enzyme BTB_c05960 ENOG4108UZ3 Transporter BTB_c05970 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTB_c05990 ENOG4105BZU Histidine kinase BTB_c06000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c06020 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BTB_c06030 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BTB_c06040 ENOG4108JB9 formate dehydrogenase BTB_c06080 ENOG4105CUB amino acid BTB_c06100 ENOG4105C59 p-type ATPase BTB_c06110 ENOG4105DAP Nicotinate phosphoribosyltransferase BTB_c06180 ENOG41073R8 VanW family BTB_c06190 ENOG4108KGH TRANSCRIPTIONal BTB_c06200 ENOG4105D9N nucleoside BTB_c06210 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BTB_c06220 ENOG4105C37 (CBS) domain BTB_c06230 ENOG4108IJ0 Aspartate ammonia-lyase BTB_c06240 ENOG4105DAA L-lactate BTB_c06270 ENOG4105DUX Transporter BTB_c06280 ENOG4108MES Periplasmic binding protein BTB_c06290 ENOG4105DQ5 transport system permease protein BTB_c06300 ENOG4108IHU transport system permease protein BTB_c06310 ENOG4105E0A ABC, transporter BTB_c06330 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BTB_c06340 ENOG4105EKQ RNA-directed DNA polymerase BTB_c06360 ENOG4105EXW epimerase dehydratase BTB_c06380 ENOG4107T89 von Willebrand factor, type A BTB_c06390 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BTB_c06400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTB_c06420 ENOG4105BZU Histidine kinase BTB_c06430 ENOG4105D5Q Arginine ornithine antiporter BTB_c06440 ENOG4107414 GntR family transcriptional regulator BTB_c06450 ENOG4105C5Y PTS System BTB_c06460 ENOG4105CG3 alpha amylase, catalytic region BTB_c06490 ENOG4105E1K spore germination protein BTB_c06510 ENOG4105CRN Aminoglycoside phosphotransferase BTB_c06520 ENOG4105BZG amino acid carrier protein BTB_c06530 ENOG4105CDA abc transporter atp-binding protein BTB_c06540 ENOG4105CT1 (ABC) transporter BTB_c06550 ENOG4105EAD ABC transporter BTB_c06560 ENOG4105DRP amino acid AbC transporter BTB_c06570 ENOG4108IQI permease BTB_c06600 ENOG4105GFR rna polymerase sigma factor BTB_c06620 ENOG4105D29 Helix-turn-helix type 11 domain protein BTB_c06630 ENOG4105NAE bifunctional deaminase-reductase domain protein BTB_c06640 ENOG4105BZU Histidine kinase BTB_c06690 ENOG4105CHH sulfate transporter BTB_c06700 ENOG41068KF Universal stress protein BTB_c06720 ENOG4105DEF Extracellular solute-binding protein, family 5 BTB_c06740 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTB_c06750 ENOG4108JQ7 (ABC) transporter BTB_c06770 ENOG4105CXY transporter BTB_c06780 ENOG41067TZ transcriptional regulator, MarR family BTB_c06790 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTB_c06800 ENOG4105ETE Transcriptional regulator (LacI family BTB_c06810 ENOG4108RVA ribokinase BTB_c06830 ENOG4105C2J ABC transporter BTB_c06840 ENOG4105CNN ABC, transporter BTB_c06850 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BTB_c06860 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BTB_c06920 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BTB_c06960 ENOG4108IMY Transcriptional regulator BTB_c07050 ENOG4108NF7 phage-type endonuclease BTB_c07060 ENOG4108PNI recT protein BTB_c07140 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_c07170 ENOG4105WXW Antirepressor BTB_c07220 ENOG4108C33 Resolvase BTB_c07410 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BTB_c07450 ENOG4105CNU cell division protein FtsK BTB_c07530 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BTB_c07540 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTB_c07550 ENOG41069ER domain protein BTB_c07560 ENOG4105VZ8 Transcriptional regulator BTB_c07570 ENOG4107D63 BTB_c07600 ENOG4105DUX Transporter BTB_c07640 ENOG4105C85 amino acid BTB_c07650 ENOG4105C7N Xanthine uracil vitamin C permease BTB_c07680 ENOG4105MA6 gCN5-related N-acetyltransferase BTB_c07720 ENOG4105CCU oxidase (Subunit III) BTB_c07730 ENOG4105BZ9 Cytochrome C oxidase, subunit I BTB_c07740 ENOG4105E2S oxidase) subunit II BTB_c07780 ENOG4106CAD Protein of unknown function (DUF3311) BTB_c07790 ENOG4105E1V na solute symporter BTB_c07820 ENOG4108NHD germination protein BTB_c07830 ENOG4105CE1 Ferrous iron transport protein b BTB_c07840 ENOG4105CE1 Ferrous iron transport protein b BTB_c07850 ENOG4105CE1 Ferrous iron transport protein b BTB_c07860 ENOG4105CVA phosphate BTB_c07870 ENOG4105C8U phosphate abc transporter BTB_c07880 ENOG4105E2Z phosphate ABC transporter (Permease BTB_c08140 ENOG41080XQ Signal transduction protein with cbs domains BTB_c08180 ENOG4105ETU transcriptional activator (TenA BTB_c08200 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BTB_c08220 ENOG4108VEU Thiamine monophosphate synthase BTB_c08230 ENOG41080HI glycine oxidase BTB_c08260 ENOG4105D06 uba thif-type nad fad binding protein BTB_c08270 ENOG4105DWF phosphomethylpyrimidine kinase BTB_c08320 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BTB_c08350 ENOG4108INS Transcriptional regulator BTB_c08380 ENOG4105C7N Xanthine uracil vitamin C permease BTB_c08400 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BTB_c08440 ENOG4105C5Y PTS System BTB_c08470 ENOG4105K63 Thioredoxin BTB_c08510 ENOG4108B31 Spore germination protein BTB_c08560 ENOG4107Y03 Nitroreductase BTB_c08570 ENOG4105ED1 spovr family BTB_c08590 ENOG4105J4Q Transcriptional regulator BTB_c08620 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BTB_c08630 ENOG4105XTG Pfam:DUF156 BTB_c08640 ENOG4105VFE sira family BTB_c08650 ENOG4107TPS domain protein BTB_c08660 ENOG4105VFE sira family BTB_c08670 ENOG41085GJ domain protein BTB_c08690 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BTB_c08700 ENOG41087NI Sulfite exporter TauE/SafE BTB_c08720 ENOG4108KGH TRANSCRIPTIONal BTB_c08770 ENOG4105EMD TRANSCRIPTIONal BTB_c08780 ENOG4105VCP PTS System BTB_c08790 ENOG4105VZJ PTS System BTB_c08830 ENOG41069ER domain protein BTB_c08840 ENOG4107RBB ABC transporter, permease BTB_c08850 ENOG4105C19 ABC transporter BTB_c08910 ENOG4105WEF catalase BTB_c08980 ENOG4107T5V SNARE associated Golgi BTB_c09050 ENOG4105CUB amino acid BTB_c09060 ENOG4107RWR Sodium hydrogen exchanger BTB_c09080 ENOG4106KNT transcriptional regulator BTB_c09160 ENOG4108YXU transcriptional regulator AsnC family BTB_c09170 ENOG4105CH7 arginosuccinase BTB_c09180 ENOG4105UBK short-chain dehydrogenase reductase BTB_c09200 ENOG4105KPY Small multidrug resistance protein BTB_c09270 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BTB_c09280 ENOG4105E5W Transporter BTB_c09300 ENOG4107RKG DJ-1/PfpI family BTB_c09310 ENOG4105CH6 catalase BTB_c09330 ENOG4105D5Q Arginine ornithine antiporter BTB_c09340 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BTB_c09360 ENOG4105C26 Dehydrogenase BTB_c09370 ENOG4105BZ1 (ABC) transporter BTB_c09380 ENOG4105BZ1 (ABC) transporter BTB_c09400 ENOG4105DRP amino acid AbC transporter BTB_c09410 ENOG4105CDA abc transporter atp-binding protein BTB_c09440 ENOG410839P BTB_c09460 ENOG4108UH6 UPF0754 membrane protein BTB_c09530 ENOG4107FQX Alpha-acetolactate decarboxylase BTB_c09580 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTB_c09590 ENOG4105D4P Coproporphyrinogen iii oxidase BTB_c09600 ENOG4105CEY Amp-dependent synthetase and ligase BTB_c09630 ENOG4105CHH sulfate transporter BTB_c09680 ENOG4105CGU Enoyl-CoA hydratase BTB_c09720 ENOG4105DER m42 family BTB_c09760 ENOG4105CTU Proline racemase BTB_c09770 ENOG4105CIF Ornithine Cyclodeaminase BTB_c09810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTB_c09820 ENOG4105C3U ABC transporter BTB_c09830 ENOG4108JQ7 (ABC) transporter BTB_c09930 ENOG4105CSH Transporter BTB_c09950 ENOG4108MRH transcriptional regulatory protein BTB_c09970 ENOG4105M6F mutator MutT protein BTB_c10000 ENOG4105CDU Replicative dna helicase BTB_c10060 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTB_c10120 ENOG4105F6J Alpha beta hydrolase fold BTB_c10210 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BTB_c10230 ENOG4105F27 Major Facilitator BTB_c10240 ENOG4105WAB arsR family transcriptional regulator BTB_c10260 ENOG4105CMT Dihydroxyacetone kinase BTB_c10280 ENOG4105CMT Dihydroxyacetone kinase BTB_c10440 ENOG4108WC5 Alpha Beta Hydrolase Fold protein BTB_c10520 ENOG4105WN5 stage II sporulation protein BTB_c10540 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_c10560 ENOG4108MJI response regulator BTB_c10570 ENOG4105BZU Histidine kinase BTB_c10580 ENOG4105BZU Histidine kinase BTB_c10650 ENOG4105DQ6 Transposase BTB_c10680 ENOG4105EKQ RNA-directed DNA polymerase BTB_c10700 ENOG4107QHE Choloylglycine hydrolase BTB_c10740 ENOG4107VRP DNA repair exonuclease BTB_c10750 ENOG4106D4I domain protein BTB_c10780 ENOG410829K Lysine exporter protein (Lyse ygga) BTB_c10830 ENOG4108MUZ hydrolase BTB_c10880 ENOG4105F0F Oxalate decarboxylase BTB_c10890 ENOG41067QW Transcriptional regulator BTB_c10900 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BTB_c10930 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BTB_c10970 ENOG4105EMN RNA polymerase sigma factor BTB_c11000 ENOG4105EEM helicase BTB_c11020 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTB_c11070 ENOG4105K59 histidine triad (HIT) protein BTB_c11200 ENOG410905X membrane-flanked domain protein BTB_c11210 ENOG4105CKV Membrane BTB_c11320 ENOG410905X membrane-flanked domain protein BTB_c11330 ENOG4105CKV Membrane BTB_c11340 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BTB_c11350 ENOG4105BZ4 penicillin-binding protein BTB_c11370 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BTB_c11380 ENOG4105C1Q protoporphyrinogen oxidase BTB_c11430 ENOG4105NA0 Transcriptional regulator BTB_c11460 ENOG4105ECB domain protein BTB_c11500 ENOG4108MK9 spermidine N(1)-acetyltransferase BTB_c11520 ENOG4106AXD BTB_c11530 ENOG4108RQ5 Beta-lactamase domain-containing protein BTB_c11540 ENOG4105DF9 Lipoate-protein, ligase BTB_c11560 ENOG4105CEY Amp-dependent synthetase and ligase BTB_c11580 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BTB_c11590 ENOG4108I5D sulfate abc transporter BTB_c11600 ENOG4105ECW sulfate abc transporter BTB_c11610 ENOG4108IJ6 ABC transporter BTB_c11620 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BTB_c11630 ENOG4107RN3 metallophosphoesterase BTB_c11640 ENOG4107TVP HD domain protein BTB_c11660 ENOG4108AEY RNA polymerase sigma factor BTB_c11670 ENOG41086D8 Transcriptional regulator BTB_c11680 ENOG41085W3 Transposase BTB_c11710 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTB_c11760 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BTB_c11770 ENOG4105C8Q Methyl-accepting chemotaxis BTB_c11780 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) BTB_c11800 ENOG4107QP3 malate synthase g BTB_c11840 ENOG4105VEQ Cold shock protein BTB_c11920 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BTB_c11930 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BTB_c12010 ENOG4105ERH Fumarylacetoacetate hydrolase BTB_c12030 ENOG4105C8Y Acetylornithine aminotransferase BTB_c12060 ENOG4105CAQ asparagine synthetase BTB_c12070 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BTB_c12080 ENOG4105CH6 catalase BTB_c12090 ENOG4105BZU Histidine kinase BTB_c12110 ENOG4108IUK alpha amylase, catalytic BTB_c12140 ENOG4105QNR S1 RNA binding domain protein BTB_c12150 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTB_c12170 ENOG4107AYK membrAne BTB_c12180 ENOG41073B9 BTB_c12200 ENOG4108KP7 hydrolase BTB_c12220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BTB_c12270 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BTB_c12280 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BTB_c12310 ENOG4105C31 Tryptophanyl-tRNA synthetase BTB_c12340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTB_c12350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTB_c12370 ENOG4108JQ7 (ABC) transporter BTB_c12380 ENOG4105UQX Mate efflux family protein BTB_c12420 ENOG4108ZCF integral membrane protein BTB_c12440 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTB_c12460 ENOG4105DPN Oligoendopeptidase f BTB_c12480 ENOG4108Z18 K06886 hemoglobin BTB_c12490 ENOG4105MIX Adenylate cyclase BTB_c12500 ENOG4106EFP UPF0738 protein BTB_c12520 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BTB_c12530 ENOG4105EMS pseudouridine synthase BTB_c12570 ENOG4105K64 Glycosyl transferase, family 2 BTB_c12610 ENOG4107TVC Glycosyl transferase, family 2 BTB_c12650 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BTB_c12660 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BTB_c12680 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BTB_c12820 ENOG4105CK7 Sodium proline symporter BTB_c12830 ENOG4105CRQ synthase (Component I) BTB_c12840 ENOG4105DDQ anthranilate synthase BTB_c12860 ENOG4105DK0 Indole-3-glycerol phosphate synthase BTB_c12870 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BTB_c12880 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BTB_c12950 ENOG4105T65 Membrane-associated protein BTB_c13010 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTB_c13050 ENOG4105C7S Dehydrogenase BTB_c13070 ENOG4105VZ8 Transcriptional regulator BTB_c13210 ENOG4105DZ1 carboxypeptidase BTB_c13220 ENOG4105VFR signal peptidase BTB_c13290 ENOG4105C26 Dehydrogenase BTB_c13300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTB_c13310 ENOG4105F38 ABC transporter, permease BTB_c13320 ENOG4105D38 putrescine abc transporter BTB_c13330 ENOG4107RUE extracellular solute-binding protein family 1 BTB_c13350 ENOG4105EYF MMPL domain protein BTB_c13370 ENOG4108YBP pseudouridine synthase BTB_c13390 ENOG4105K4I Scp-like extracellular BTB_c13400 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BTB_c13410 ENOG4105CQB FAD linked oxidase domain protein BTB_c13440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c13450 ENOG4105BZU Histidine kinase BTB_c13460 ENOG4105JXH GntR family transcriptional regulator BTB_c13500 ENOG4106A3R peptidase BTB_c13520 ENOG4108QTI )-transporter BTB_c13530 ENOG4107TS3 membrane protein, TerC BTB_c13540 ENOG4105CZN Potassium uptake protein BTB_c13550 ENOG410681C small acid-soluble spore protein BTB_c13560 ENOG4108Z7G MaoC domain protein dehydratase BTB_c13600 ENOG4105CHR reductase BTB_c13660 ENOG4105C4Y ABC transporter BTB_c13670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTB_c13680 ENOG4107RCV ABC transporter, permease BTB_c13720 ENOG4105E98 transcriptional regulator DeoR family BTB_c13750 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BTB_c13770 ENOG4105PXI polysaccharide deacetylase BTB_c13790 ENOG4105BZU Histidine kinase BTB_c13800 ENOG41090MY MarR family Transcriptional regulator BTB_c13820 ENOG4106DF1 BTB_c13840 ENOG4105BZU Histidine kinase BTB_c13850 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BTB_c13860 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BTB_c13870 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BTB_c13950 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BTB_c13960 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BTB_c13970 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BTB_c13980 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BTB_c13990 ENOG4105CZV ABC transporter BTB_c14010 ENOG4105CJ1 ABC, transporter BTB_c14090 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BTB_c14100 ENOG4105EA8 2-Nitropropane dioxygenase BTB_c14110 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BTB_c14130 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BTB_c14180 ENOG4105NQC Flavodoxin BTB_c14260 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BTB_c14320 ENOG4105CZN Potassium uptake protein BTB_c14330 ENOG41063Y9 BTB_c14340 ENOG4105KBJ sporulation protein ytfj BTB_c14380 ENOG4105CM2 brancheD-chain amino acid aminotransferase BTB_c14390 ENOG4105C7K acetolactate synthase BTB_c14400 ENOG4108ZP8 Acetolactate synthase small subunit BTB_c14410 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BTB_c14440 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BTB_c14480 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BTB_c14490 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BTB_c14500 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BTB_c14550 ENOG4107RVV histidinol phosphate phosphatase, hisj family BTB_c14580 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BTB_c14590 ENOG4105E0M Sulfatase BTB_c14610 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BTB_c14650 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BTB_c14660 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BTB_c14680 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BTB_c14690 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BTB_c14700 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BTB_c14710 ENOG4105C8J )-transporter BTB_c14760 ENOG4105DFD Na H antiporter BTB_c14800 ENOG4105ENE Histidine kinase BTB_c14810 ENOG4105WH1 Two component transcriptional regulator luxr family BTB_c14850 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTB_c14900 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BTB_c14940 ENOG4105CJ3 phosphate transporter BTB_c14950 ENOG4107GRR phosphate transport regulator BTB_c14960 ENOG4105BZ4 penicillin-binding protein BTB_c14990 ENOG4105BZU Histidine kinase BTB_c15000 ENOG4105I3N Conserved Protein BTB_c15030 ENOG4105BZU Histidine kinase BTB_c15090 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTB_c15100 ENOG4105DZ1 carboxypeptidase BTB_c15110 ENOG4108JIC nucleoside recognition domain protein BTB_c15130 ENOG4105FE9 pseudouridine synthase BTB_c15140 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTB_c15150 ENOG4107TWT Cytochrome c biogenesis protein BTB_c15160 ENOG4105CRE cytochrome C BTB_c15170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c15180 ENOG4105BZU Histidine kinase BTB_c15190 ENOG4108WBT adenosyltransferase BTB_c15220 ENOG4108SAX Membrane BTB_c15250 ENOG4105C9U ATP-dependent DNA helicase RecQ BTB_c15260 ENOG4105I7S Abortive infection protein BTB_c15280 ENOG4107RGJ metallophosphoesterase BTB_c15290 ENOG4108XDN Transcriptional regulator BTB_c15300 ENOG4108S6Z Negative regulator of genetic competence BTB_c15350 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BTB_c15360 ENOG4107RB3 L-asparaginase BTB_c15430 ENOG4105S2F BTB_c15440 ENOG41065D1 BTB_c15500 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BTB_c15530 ENOG4105XXQ heptaprenyl diphosphate synthase component I BTB_c15550 ENOG4105EAH synthase BTB_c15560 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BTB_c15570 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BTB_c15600 ENOG41068YB TPR repeat-containing protein BTB_c15630 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BTB_c15640 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BTB_c15710 ENOG4108JYZ YitT family BTB_c15720 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BTB_c15750 ENOG4105FJR Lmbe family BTB_c15760 ENOG4105CPK Glycosyl transferase (Group 1 BTB_c15800 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BTB_c15830 ENOG4105DVT helicase BTB_c15840 ENOG4105YAC BTB_c15880 ENOG4105CSM endonuclease III BTB_c15890 ENOG4105BZ4 penicillin-binding protein BTB_c15980 ENOG4106F55 Protein of unknown function (DUF1273) BTB_c16000 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BTB_c16020 ENOG4105DVT helicase BTB_c16030 ENOG4105CTD carboxy-peptidase BTB_c16050 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BTB_c16060 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BTB_c16070 ENOG4105C2W permease BTB_c16080 ENOG4105DHF Membrane BTB_c16100 ENOG410890F Dynamin family BTB_c16120 ENOG4108W0I acetyltransferase BTB_c16140 ENOG4105KHC sulfurtransferase BTB_c16230 ENOG4105HTX biosynthesis protein BTB_c16290 ENOG4105CPK Glycosyl transferase (Group 1 BTB_c16320 ENOG4108SZE gCN5-related N-acetyltransferase BTB_c16360 ENOG41081VK Ribonuclease BTB_c16490 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTB_c16510 ENOG4107RWR Sodium hydrogen exchanger BTB_c16520 ENOG4108Z5V transcriptional regulator, merr family BTB_c16540 ENOG4105H67 Protein of unknown function (DUF421) BTB_c16550 ENOG41080C8 DUF218 domain BTB_c16670 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTB_c16690 ENOG4107R0U MotA TolQ exbB proton channel BTB_c16700 ENOG4105ER2 Ompa motb domain protein BTB_c16710 ENOG4107YTP response regulator receiver protein BTB_c16720 ENOG4105CBS Chea signal transduction histidine kinase BTB_c16730 ENOG4105DD5 Flagellar motor switch protein BTB_c16760 ENOG4105BZU Histidine kinase BTB_c16800 ENOG4105E1Q flagellar hook-associated protein BTB_c16810 ENOG4105DTJ flagellar hook-associated protein BTB_c16850 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BTB_c16860 ENOG4108ZC9 flagellar basal-body rod protein flgc BTB_c16870 ENOG41075Z6 flagellar hook-basal body complex protein fliE BTB_c16880 ENOG4107U2N Flagellar M-ring protein BTB_c16890 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BTB_c16950 ENOG4105BZE flagellar hook protein, FlgE BTB_c16980 ENOG4107R88 Chemotaxis protein (CheV) BTB_c17000 ENOG4105I03 Flagellin BTB_c17010 ENOG4105I03 Flagellin BTB_c17020 ENOG4105E4C Lytic transglycosylase catalytic BTB_c17040 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BTB_c17050 ENOG4105DD5 Flagellar motor switch protein BTB_c17070 ENOG4105CN7 Flagellar biosynthetic protein FliP BTB_c17080 ENOG4105VS8 Flagellar biosynthetic protein fliq BTB_c17100 ENOG4105D00 flagellar biosynthetic protein flhB BTB_c17110 ENOG4105D7B Flagellar biosynthesis protein flha BTB_c17120 ENOG4105FZW flagellar biosynthesis regulator FlhF BTB_c17130 ENOG4105KTQ flagellar basal-body rod protein BTB_c17140 ENOG4105CPU Monooxygenase BTB_c17150 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTB_c17210 ENOG4105KAC Antibiotic biosynthesis monooxygenase BTB_c17220 ENOG4107QZ7 Cellulose synthase catalytic subunit BTB_c17270 ENOG4105DUM transcriptional regulator, lysR family BTB_c17280 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTB_c17300 ENOG4105D38 putrescine abc transporter BTB_c17380 ENOG4105CVJ phosphoglycerate mutase BTB_c17400 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BTB_c17440 ENOG4105CAQ asparagine synthetase BTB_c17480 ENOG4105PGM cation diffusion facilitator family transporter BTB_c17500 ENOG4105DRR Transcriptional regulator, GntR family BTB_c17510 ENOG4108UZ3 Transporter BTB_c17530 ENOG4105CKI cobalamin synthesis protein BTB_c17540 ENOG4108PJD permease BTB_c17570 ENOG4105DFD Na H antiporter BTB_c17580 ENOG4105VUF Transcriptional regulator BTB_c17600 ENOG4105C9Q fumarate hydratase class II BTB_c17630 ENOG4107QJQ Mate efflux family protein BTB_c17640 ENOG4105EC3 peptidase S51, dipeptidase E BTB_c17680 ENOG4107QIV Cytochrome c biogenesis protein BTB_c17690 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTB_c17720 ENOG4107JM4 Tetratricopeptide repeat BTB_c17740 ENOG4105BZC d-serine deaminase BTB_c17750 ENOG4106BRA Membrane BTB_c17830 ENOG4105CJ1 ABC, transporter BTB_c17870 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BTB_c17890 ENOG4108IJ0 Aspartate ammonia-lyase BTB_c17900 ENOG4105C6K Malic enzyme BTB_c18020 ENOG4105FVX BTB_c18040 ENOG4105CSR polyphosphate kinase 2 BTB_c18050 ENOG4105U3E Transcriptional regulator BTB_c18070 ENOG4105DXI Major Facilitator superfamily BTB_c18110 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BTB_c18120 ENOG4105EU0 Major facilitator Superfamily BTB_c18130 ENOG4105C6T cysteine synthase BTB_c18170 ENOG4105C8J )-transporter BTB_c18190 ENOG4105X5K response regulator receiver protein BTB_c18200 ENOG4105H67 Protein of unknown function (DUF421) BTB_c18250 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BTB_c18260 ENOG4105CHR reductase BTB_c18270 ENOG4105CM2 brancheD-chain amino acid aminotransferase BTB_c18280 ENOG4105C7K acetolactate synthase BTB_c18300 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BTB_c18320 ENOG4105C7B Threonine dehydratase BTB_c18370 ENOG4105C6X Major Facilitator BTB_c18380 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BTB_c18400 ENOG4105DY9 regulatoR BTB_c18410 ENOG4105CYC Transferase BTB_c18450 ENOG4105EQ0 Major Facilitator superfamily BTB_c18460 ENOG4108IND Tetr family transcriptional regulator BTB_c18480 ENOG41068WN BTB_c18530 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BTB_c18560 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BTB_c18580 ENOG4105C0X amino acid BTB_c18660 ENOG410849A acetyltransferase, (GNAT) family BTB_c18700 ENOG4107RHR regulatoR BTB_c18720 ENOG4105D9N nucleoside BTB_c18730 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BTB_c18790 ENOG410811B TRANSCRIPTIONal BTB_c18820 ENOG4107RAQ aminopeptidase BTB_c18840 ENOG4107R16 Multicopper oxidase BTB_c18920 ENOG4108T5E Copper resistance protein BTB_c18930 ENOG4105KTB nuclear export factor GLE1 BTB_c18940 ENOG4107RT3 EamA-like transporter family BTB_c18950 ENOG4105GZI Transcriptional regulator BTB_c18960 ENOG4108Z40 Transcriptional regulator BTB_c18970 ENOG4107ZXU DSBA oxidoreductase BTB_c18980 ENOG4108TVJ Nitroreductase BTB_c19000 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BTB_c19080 ENOG41085W3 Transposase BTB_c19230 ENOG4105C2M dna polymerase I BTB_c19420 ENOG4105KRN Transcriptional regulator, abrb family BTB_c19710 ENOG4105XSJ toxin secretion phage lysis holin BTB_c19900 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BTB_c19910 ENOG4106F5Q Membrane BTB_c19920 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BTB_c19940 ENOG4105CKI cobalamin synthesis protein BTB_c19960 ENOG4105C0Z ABC transporter BTB_c19970 ENOG4108IV0 ABC, transporter BTB_c19980 ENOG4105C32 Amino acid ABC transporter (Permease) BTB_c20000 ENOG4105EGI Transcriptional regulator BTB_c20020 ENOG4105MDS 4-oxalocrotonate tautomerase BTB_c20060 ENOG4105C4M (Ubiquinol oxidase) subunit I BTB_c20070 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BTB_c20080 ENOG4108JJ9 ABC, transporter BTB_c20090 ENOG4108JJ8 (ABC) transporter BTB_c20110 ENOG4105K64 Glycosyl transferase, family 2 BTB_c20130 ENOG4108UT6 Transferase hexapeptide repeat containing protein BTB_c20240 ENOG4105BZ1 (ABC) transporter BTB_c20250 ENOG4105EFI regulatoR BTB_c20260 ENOG4105BZU Histidine kinase BTB_c20300 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BTB_c20310 ENOG4108ZJ4 polysaccharide deacetylase BTB_c20350 ENOG4105D6E homoserine dehydrogenase BTB_c20370 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BTB_c20400 ENOG4108KGH TRANSCRIPTIONal BTB_c20420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTB_c20430 ENOG4105BZU Histidine kinase BTB_c20440 ENOG4107VMI polysaccharide deacetylase BTB_c20460 ENOG4105KT7 mgtC SapB transporter BTB_c20470 ENOG4105VRR gCN5-related N-acetyltransferase BTB_c20490 ENOG4105DUU IucA IucC family protein BTB_c20500 ENOG4105CEY Amp-dependent synthetase and ligase BTB_c20530 ENOG4108WBH protein TIM barrel BTB_c20540 ENOG4105YWU small acid-soluble spore protein BTB_c20560 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BTB_c20570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTB_c20670 ENOG4105KRN Transcriptional regulator, abrb family BTB_c20690 ENOG4105YVS arsR family transcriptional regulator BTB_c20700 ENOG4105CPC Aldo Keto reductase BTB_c20710 ENOG4107XZQ multidrug resistance protein BTB_c20760 ENOG4105C8Q Methyl-accepting chemotaxis BTB_c20790 ENOG4108K88 Membrane BTB_c20800 ENOG4108WPJ Ferritin-like domain BTB_c20830 ENOG4105DEN Luciferase family BTB_c20860 ENOG4105VMI -acetyltransferase BTB_c20870 ENOG4107QM2 Aldo Keto reductase BTB_c20880 ENOG4105CKI cobalamin synthesis protein BTB_c20900 ENOG4105DSE periplasmic solute binding protein BTB_c20920 ENOG4105K4T epimerase BTB_c21030 ENOG4107T5V SNARE associated Golgi BTB_c21060 ENOG4108PJD permease BTB_c21080 ENOG4108S4H thioesterase Superfamily protein BTB_c21090 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTB_c21130 ENOG4105SXS Protein of unknown function (DUF456) BTB_c21140 ENOG4105C37 (CBS) domain BTB_c21200 ENOG4108Z7R Chaperone CsaA BTB_c21230 ENOG4108ZRV stage ii sporulation protein p BTB_c21250 ENOG4108VXD carboxy-peptidase BTB_c21310 ENOG4108ZRV stage ii sporulation protein p BTB_c21330 ENOG4108X4Q Hydrolase BTB_c21340 ENOG41082F9 transcriptional regulator BTB_c21350 ENOG4105D94 Major Facilitator Superfamily BTB_c21370 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BTB_c21380 ENOG4107RBS Methyltransferase BTB_c21410 ENOG41087PP glycosyltransferase MGT family BTB_c21420 ENOG4108JYZ YitT family BTB_c21430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTB_c21490 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BTB_c21590 ENOG4105KBJ sporulation protein ytfj BTB_c21640 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTB_c21680 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BTB_c21690 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BTB_c21710 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BTB_c21720 ENOG4105EMN RNA polymerase sigma factor BTB_c21750 ENOG4105CNW domain protein BTB_c21770 ENOG4108V06 Glutathione peroxidase BTB_c21800 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BTB_c21820 ENOG4108IUE nitrate reductase beta subunit BTB_c21830 ENOG4105R3A Nitrate reductase BTB_c21850 ENOG4107V6Q Cyclic nucleotide-binding domain BTB_c21860 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BTB_c21870 ENOG4105D06 uba thif-type nad fad binding protein BTB_c21880 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTB_c21890 ENOG4108ZAF Molybdopterin BTB_c21940 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BTB_c21950 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BTB_c21960 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BTB_c21970 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BTB_c21980 ENOG4108IFG nitrite reductase, (NAD(P)H) BTB_c21990 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BTB_c22060 ENOG4105MCT stage V sporulation protein S BTB_c22080 ENOG4108IBT Inherit from COG: transposase BTB_c22120 ENOG4105C5H ABC transporter BTB_c22150 ENOG4108UUM single-stranded DNA-binding protein BTB_c22200 ENOG4107YX5 Pfam:DUF548 BTB_c22210 ENOG4105C75 arginyL-tRNA synthetase BTB_c22240 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BTB_c22290 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BTB_c22300 ENOG4105C5S asparaginyl-tRNA synthetase BTB_c22340 ENOG4105EC2 ftsk spoIIIe BTB_c22480 ENOG4105C8J )-transporter BTB_c22520 ENOG4107XGZ Hydrolase BTB_c22530 ENOG4105CY2 Citrate transporter BTB_c22570 ENOG4105KD7 acetyltransferase BTB_c22590 ENOG4105VMP Transcriptional regulator BTB_c22600 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BTB_c22650 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BTB_c22670 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BTB_c22700 ENOG4107RVG penicillin-binding protein BTB_c22720 ENOG4105E9Q Acyl-transferase BTB_c22730 ENOG4108UT2 hemolysin iii BTB_c22750 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BTB_c22770 ENOG4108RCR degv family BTB_c22790 ENOG4108KF3 Electron transport protein SCO1 SenC BTB_c22800 ENOG4107Y70 Heat shock protein BTB_c22810 ENOG4105CAQ asparagine synthetase BTB_c22840 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BTB_c22850 ENOG4108MES Periplasmic binding protein BTB_c22860 ENOG4105F0I Aminotransferase BTB_c22910 ENOG4105D8X mechanosensitive ion channel BTB_c22920 ENOG4105BZU Histidine kinase BTB_c22930 ENOG4105WH1 Two component transcriptional regulator luxr family BTB_c22940 ENOG4106KNT transcriptional regulator BTB_c22950 ENOG4107ZY0 Phenazine biosynthesis-like protein BTB_c23030 ENOG4105CMG Carbohydrate kinase BTB_c23040 ENOG4105C6Z Gluconate BTB_c23060 ENOG4108YV3 Protein of unknown function (DUF2711) BTB_c23120 ENOG4108IJ8 ABC transporter BTB_c23130 ENOG4105E90 ABC transporter BTB_c23210 ENOG4105C37 (CBS) domain BTB_c23270 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTB_c23300 ENOG4107S4Y M20 DapE family protein YgeY BTB_c23310 ENOG4108TSC N-acetyltransferase BTB_c23320 ENOG4108JUB Transcriptional regulator BTB_c23330 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BTB_c23420 ENOG410841Q phosphoesterase PA-phosphatase related protein BTB_c23440 ENOG4105SZ6 Thioredoxin BTB_c23450 ENOG4105KNA -acetyltransferase BTB_c23520 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTB_c23640 ENOG4105BZ4 penicillin-binding protein BTB_c23660 ENOG4105CZM Major Facilitator BTB_c23670 ENOG4105W8X HesB YadR YfhF-family protein BTB_c23690 ENOG4105DXD 2-methylcitrate dehydratase BTB_c23700 ENOG4105CR4 methylisocitrate lyase BTB_c23710 ENOG4105C1G acyl-Coa dehydrogenase BTB_c23720 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BTB_c23740 ENOG4105N14 lysine exporter protein LysE YggA BTB_c23750 ENOG4105E39 Enoyl-CoA hydratase BTB_c23780 ENOG4107RFY SbcCD D subunit BTB_c23790 ENOG4105EYH Exonuclease BTB_c23830 ENOG4105FCD Major Facilitator BTB_c23840 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BTB_c23850 ENOG4105E4F Isochorismate synthase BTB_c23860 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BTB_c23870 ENOG4105WQI isochorismatase BTB_c23880 ENOG4105CEY Amp-dependent synthetase and ligase BTB_c23890 ENOG4105WQT MbtH domain protein BTB_c23900 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTB_c23930 ENOG4105K70 DNA-binding protein BTB_c23970 ENOG4105BZG amino acid carrier protein BTB_c24010 ENOG4105FE9 pseudouridine synthase BTB_c24020 ENOG4105C22 threonyL-tRNA synthetase BTB_c24030 ENOG4105C19 ABC transporter BTB_c24130 ENOG41081I9 integral membrane protein BTB_c24150 ENOG4108Y4K DNA-binding transcriptional activator BTB_c24180 ENOG4107MII Sugar-specific transcriptional regulator TrmB BTB_c24200 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BTB_c24220 ENOG4105EYF MMPL domain protein BTB_c24270 ENOG4105WCN acetyltransferase BTB_c24320 ENOG4105C1Q protoporphyrinogen oxidase BTB_c24340 ENOG41068WN BTB_c24400 ENOG4107V2S Transcriptional regulator BTB_c24410 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BTB_c24440 ENOG4105DND Transcriptional regulator BTB_c24450 ENOG4108RPX mosc domain containing protein BTB_c24480 ENOG4105BZ1 (ABC) transporter BTB_c24490 ENOG4105BZ1 (ABC) transporter BTB_c24710 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTB_c24730 ENOG4108IBT Inherit from COG: transposase BTB_c24770 ENOG4108JCI Transcriptional regulator BTB_c24840 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BTB_c24850 ENOG4108KPJ rna polymerase sigma factor BTB_c24900 ENOG4105F32 YngK protein BTB_c24940 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BTB_c24950 ENOG4105RD7 BadF BadG BcrA BcrD BTB_c24960 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BTB_c24980 ENOG4105C7B Threonine dehydratase BTB_c24990 ENOG4108INS Transcriptional regulator BTB_c25020 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BTB_c25030 ENOG4105C1J atp-dependent rna helicase BTB_c25080 ENOG41088CC tellurite resistance protein tehB BTB_c25100 ENOG4108I0C methyltransferase BTB_c25110 ENOG4107RA9 decarboxylase BTB_c25120 ENOG4105K56 Transcriptional regulator BTB_c25130 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BTB_c25190 ENOG4105CIN aminoacyl-histidine dipeptidase BTB_c25250 ENOG4105KRN Transcriptional regulator, abrb family BTB_c25270 ENOG4105EJ9 Membrane BTB_c25280 ENOG4105EQK -acetyltransferase BTB_c25360 ENOG4105W8Z 4'-phosphopantetheinyl transferase BTB_c25410 ENOG4105CSV Glutaminase BTB_c25450 ENOG4108Q8B Spore germination protein BTB_c25460 ENOG4108NHD germination protein BTB_c25470 ENOG4105II7 pyrroline-5-carboxylate reductase BTB_c25480 ENOG4105CUB amino acid BTB_c25490 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BTB_c25500 ENOG41075H3 AraC family transcriptional regulator BTB_c25550 ENOG4105BZU Histidine kinase BTB_c25570 ENOG4107S9D Alpha beta hydrolase BTB_c25700 ENOG41085W3 Transposase BTB_c25720 ENOG4107RVG penicillin-binding protein BTB_c25750 ENOG4105CJN penicillin-binding protein BTB_c25760 ENOG4107RF6 penicillin-binding protein BTB_c25790 ENOG4105DIN metallophosphoesterase BTB_c25810 ENOG4105CJ1 ABC, transporter BTB_c25830 ENOG4107Z3H Transcriptional regulator, TetR family BTB_c25860 ENOG4105C1G acyl-Coa dehydrogenase BTB_c25870 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BTB_c25880 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BTB_c25890 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BTB_c25900 ENOG4105E39 Enoyl-CoA hydratase BTB_c25910 ENOG4107QX3 carboxylase BTB_c25920 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BTB_c25940 ENOG41085W3 Transposase BTB_c26000 ENOG4105DZ1 carboxypeptidase BTB_c26030 ENOG4105T9C HD domain BTB_c26050 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BTB_c26170 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BTB_c26190 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BTB_c26230 ENOG4105KVH Transcriptional regulator BTB_c26350 ENOG4105EFA 4-hydroxyphenylacetate BTB_c26380 ENOG4105CPQ Dehydrogenase BTB_c26400 ENOG410900G Protein of unknown function (DUF421) BTB_c26420 ENOG4108V4B ThiJ pfpI BTB_c26450 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BTB_c26470 ENOG4105DK7 lysyl-tRNA synthetase BTB_c26620 ENOG4105D6E homoserine dehydrogenase BTB_c26640 ENOG4105CPF Cell wall formation (By similarity) BTB_c26650 ENOG4105ETU transcriptional activator (TenA BTB_c26700 ENOG4105VTR Integrase BTB_c26860 ENOG4105KRN Transcriptional regulator, abrb family BTB_c27110 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BTB_c27230 ENOG41085W3 Transposase BTB_c27250 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BTB_c27440 ENOG410667J hydrolase BTB_c27450 ENOG4105BZU Histidine kinase BTB_c27460 ENOG4107RF6 penicillin-binding protein BTB_c27520 ENOG4108JJB ABC transporter BTB_c27540 ENOG4108HGU Histidine kinase BTB_c27650 ENOG4105CB2 alcohol dehydrogenase BTB_c27660 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BTB_c27670 ENOG4105CJN penicillin-binding protein BTB_c27780 ENOG4107Y80 Major Facilitator superfamily BTB_c27820 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BTB_c27880 ENOG4107Y9U Membrane BTB_c27970 ENOG4105FCD Major Facilitator BTB_c27990 ENOG4105E09 nadh pyrophosphatase BTB_c28000 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BTB_c28070 ENOG4108XI2 Domain of unknown function (DUF1963) BTB_c28120 ENOG4108NRW Phospholipase, patatin family BTB_c28130 ENOG4105KWG Pfam:DUF1696 BTB_c28200 ENOG4105PKS Excinuclease abc c subunit domain protein BTB_c28280 ENOG4107VFR oxidoreductase BTB_c28330 ENOG4105U0R haloacid dehalogenase-like hydrolase BTB_c28340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c28350 ENOG4105BZU Histidine kinase BTB_c28410 ENOG4107WD8 ABC transporter, permease BTB_c28440 ENOG4105DY8 decarboxylase BTB_c28470 ENOG4108IUM Glycogen debranching enzyme BTB_c28490 ENOG4105CGH 5'-nucleotidase BTB_c28520 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BTB_c28540 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BTB_c28550 ENOG4105FDR Membrane BTB_c28570 ENOG4105CIS alcohol dehydrogenase BTB_c28580 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BTB_c28670 ENOG4105MSI germination protein ypeb BTB_c28730 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BTB_c28740 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BTB_c28750 ENOG4107Z3H Transcriptional regulator, TetR family BTB_c28800 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BTB_c28840 ENOG4105E98 transcriptional regulator DeoR family BTB_c28870 ENOG41062ES Transcriptional regulator BTB_c28910 ENOG4107QKR Dehydrogenase BTB_c28930 ENOG4107RUY (E1 component), alpha subunit BTB_c28960 ENOG4105E1F short-chain dehydrogenase reductase BTB_c28970 ENOG4105RHY Pfam:UPF0157 BTB_c29030 ENOG4107SQ8 Glycine betaine BTB_c29040 ENOG4108IJ7 Glycine betaine BTB_c29090 ENOG4105E66 phosphoriboisomerase A BTB_c29100 ENOG41082BV acetyltransferase BTB_c29110 ENOG4108M1A Chitin-binding protein BTB_c29120 ENOG41087PP glycosyltransferase MGT family BTB_c29170 ENOG4105MSB protein, conserved in bacteria BTB_c29220 ENOG4108Z7F N-acetyltransferase BTB_c29270 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BTB_c29280 ENOG4105EEM helicase BTB_c29300 ENOG4105DQ6 Transposase BTB_c29340 ENOG4105C9U ATP-dependent DNA helicase RecQ BTB_c29450 ENOG4108M1A Chitin-binding protein BTB_c29490 ENOG4105BZG amino acid carrier protein BTB_c29500 ENOG4105C26 Dehydrogenase BTB_c29510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BTB_c29520 ENOG4105CTU Proline racemase BTB_c29530 ENOG4105CTU Proline racemase BTB_c29540 ENOG41080HI glycine oxidase BTB_c29560 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BTB_c29630 ENOG4105DCI Phosphohydrolase BTB_c29640 ENOG4107T5V SNARE associated Golgi BTB_c29660 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BTB_c29700 ENOG4105DTQ mandelate racemase muconate lactonizing BTB_c29730 ENOG4107SET aldo keto reductase BTB_c29790 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BTB_c29800 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTB_c29810 ENOG4105BZU Histidine kinase BTB_c29820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c29850 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BTB_c29890 ENOG4105DPN Oligoendopeptidase f BTB_c29900 ENOG4105EPR degv family BTB_c29990 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BTB_c30000 ENOG4106K7D Major facilitator family transporter BTB_c30050 ENOG4107BMA Transglycosylase associated protein BTB_c30090 ENOG41089UC methyltransferase, type 11 BTB_c30170 ENOG4105CHM Aminotransferase BTB_c30200 ENOG4108ZMI UPF0477 protein BTB_c30230 ENOG4105DVE abc transporter atp-binding protein BTB_c30320 ENOG4105C02 permease BTB_c30340 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BTB_c30350 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BTB_c30360 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BTB_c30370 ENOG4105D7T ABC transporter BTB_c30450 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BTB_c30530 ENOG4107VC0 DNA alkylation repair enzyme BTB_c30550 ENOG4105C6T cysteine synthase BTB_c30560 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BTB_c30590 ENOG4107VMI polysaccharide deacetylase BTB_c30610 ENOG4108ZCF integral membrane protein BTB_c30620 ENOG4105E0M Sulfatase BTB_c30630 ENOG4105C5H ABC transporter BTB_c30640 ENOG4105EYF MMPL domain protein BTB_c30660 ENOG41082JN Transcriptional regulator BTB_c30710 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BTB_c30720 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BTB_c30810 ENOG41069ER domain protein BTB_c30830 ENOG4105DNP FAD linked oxidase domain protein BTB_c30880 ENOG4105D4B ABC, transporter BTB_c30890 ENOG4105F5R ABC transporter BTB_c30900 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BTB_c30920 ENOG4105C2J ABC transporter BTB_c30930 ENOG4105DKT Transcriptional regulator BTB_c30940 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BTB_c30960 ENOG41061GT Aldolase BTB_c30980 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BTB_c31000 ENOG4105YVS arsR family transcriptional regulator BTB_c31040 ENOG4105II7 pyrroline-5-carboxylate reductase BTB_c31060 ENOG4107258 Transcriptional regulator BTB_c31110 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BTB_c31130 ENOG4105ECK Fatty Acid Desaturase BTB_c31150 ENOG4107RBI VanW family BTB_c31160 ENOG4105G6Z alkaline phosphatase BTB_c31180 ENOG4105VMP Transcriptional regulator BTB_c31220 ENOG41068WN BTB_c31270 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BTB_c31310 ENOG4105C8Y Acetylornithine aminotransferase BTB_c31390 ENOG4108TVJ Nitroreductase BTB_c31400 ENOG4105FS7 Transcriptional regulator BTB_c31440 ENOG4105WEC Molybdate metabolism regulator BTB_c31450 ENOG4105CMR udp-glucose 4-epimerase BTB_c31500 ENOG4108DMH HTH_ARAC BTB_c31510 ENOG4108XET gCN5-related N-acetyltransferase BTB_c31540 ENOG4108PCN EamA-like transporter family BTB_c31640 ENOG410635A Membrane BTB_c31660 ENOG4108IQI permease BTB_c31680 ENOG4105F1N DNA alkylation repair BTB_c31700 ENOG4105BZU Histidine kinase BTB_c31710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c31730 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BTB_c31800 ENOG4107RF6 penicillin-binding protein BTB_c31810 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BTB_c31820 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BTB_c31850 ENOG4105E7W lamb ycsf family protein BTB_c31870 ENOG4105P4J Allophanate hydrolase, subunit 1 BTB_c31880 ENOG4107258 Transcriptional regulator BTB_c31910 ENOG4106N3A copper homeostasis protein cutc BTB_c31920 ENOG4108ZHR arsR family transcriptional regulator BTB_c31940 ENOG4105FDT acyl-CoA dehydrogenase BTB_c31980 ENOG4105DWD nucleoside recognition domain protein BTB_c32100 ENOG4105CGH 5'-nucleotidase BTB_c32120 ENOG4105CHJ isochorismatase hydrolase BTB_c32180 ENOG41090MY MarR family Transcriptional regulator BTB_c32300 ENOG4105E1K spore germination protein BTB_c32330 ENOG4108606 TspO/MBR family BTB_c32340 ENOG4105CVP deoxyribo-dipyrimidine photolyase BTB_c32370 ENOG4108TWJ NADH dehydrogenase subunit 5 BTB_c32380 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BTB_c32400 ENOG4107VMI polysaccharide deacetylase BTB_c32410 ENOG4105KY5 gCN5-related N-acetyltransferase BTB_c32420 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BTB_c32440 ENOG4105D6J arsenicaL-resistance protein BTB_c32450 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BTB_c32460 ENOG41085FC arsR family transcriptional regulator BTB_c32480 ENOG4105NAE bifunctional deaminase-reductase domain protein BTB_c32500 ENOG4107P5I polyketide synthase BTB_c32510 ENOG4108IG5 Transcriptional regulator BTB_c32610 ENOG4105F27 Major Facilitator BTB_c32620 ENOG4105M4P Tetr family transcriptional regulator BTB_c32630 ENOG4105CHR reductase BTB_c32640 ENOG4108YXU transcriptional regulator AsnC family BTB_c32740 ENOG4105N0V mono-oxygenase ydhR BTB_c32790 ENOG41085W3 Transposase BTB_c32820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c32830 ENOG41062D9 Histidine kinase BTB_c32910 ENOG4105C19 ABC transporter BTB_c32980 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BTB_c32990 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTB_c33040 ENOG4105K6H D-cysteine desulfhydrase BTB_c33090 ENOG4105E0Y RtcB Protein BTB_c33110 ENOG4105JQZ Methyltransferase BTB_c33140 ENOG4105DNP FAD linked oxidase domain protein BTB_c33160 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BTB_c33200 ENOG4105BZU Histidine kinase BTB_c33220 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BTB_c33250 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BTB_c33290 ENOG4108JQ1 Dehydrogenase BTB_c33300 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BTB_c33330 ENOG41082W1 Cupin 2, conserved barrel domain protein BTB_c33340 ENOG410874W AraC family transcriptional regulator BTB_c33370 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTB_c33410 ENOG4108VXD carboxy-peptidase BTB_c33420 ENOG4105PNM synthesis protein BTB_c33440 ENOG4108ISG Major Facilitator BTB_c33470 ENOG4107MII Sugar-specific transcriptional regulator TrmB BTB_c33480 ENOG4105CZM Major Facilitator BTB_c33530 ENOG4105CRW Short chain fatty acid transporter BTB_c33550 ENOG4105DYS nad(p)h dehydrogenase (quinone) BTB_c33670 ENOG4108K8S endonuclease I BTB_c33690 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BTB_c33710 ENOG41067QW Transcriptional regulator BTB_c33740 ENOG4108Z66 YbaK ebsC protein BTB_c33750 ENOG4105CUT histidyl-tRNA synthetase BTB_c33780 ENOG4105KVH Transcriptional regulator BTB_c33790 ENOG4108RCM Nitroreductase BTB_c33850 ENOG4108PSK reductase BTB_c34000 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BTB_c34010 ENOG4105DKQ ROK family BTB_c34030 ENOG4108UW5 maltose o-acetyltransferase BTB_c34040 ENOG4105C31 Tryptophanyl-tRNA synthetase BTB_c34050 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BTB_c34110 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BTB_c34130 ENOG4105EV4 Multidrug resistance protein mdtH BTB_c34180 ENOG4105C37 (CBS) domain BTB_c34210 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BTB_c34220 ENOG4105FAW cDP-glucose 4,6-dehydratase BTB_c34290 ENOG4105DDN Pentapeptide repeat-containing protein BTB_c34300 ENOG4105XDF Protein of unknown function (DUF1272) BTB_c34310 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BTB_c34320 ENOG4105CMG Carbohydrate kinase BTB_c34330 ENOG4105C6Z Gluconate BTB_c34360 ENOG4105CV1 Transketolase (EC 2.2.1.1) BTB_c34370 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BTB_c34380 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BTB_c34390 ENOG4105CIS alcohol dehydrogenase BTB_c34400 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BTB_c34420 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BTB_c34450 ENOG4105C8Q Methyl-accepting chemotaxis BTB_c34460 ENOG4108UX3 '-nucleotidase BTB_c34470 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BTB_c34480 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BTB_c34490 ENOG4105KVH Transcriptional regulator BTB_c34520 ENOG4105CV8 reductase BTB_c34530 ENOG4105F27 Major Facilitator BTB_c34550 ENOG41090KN UPF0303 protein BTB_c34580 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BTB_c34590 ENOG4105CHH sulfate transporter BTB_c34620 ENOG4105C44 Serine transporter BTB_c34690 ENOG4105KVH Transcriptional regulator BTB_c34700 ENOG4108TZY GntR Family Transcriptional Regulator BTB_c34720 ENOG4105D9R oxidoreductase BTB_c34730 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BTB_c34740 ENOG4105KVH Transcriptional regulator BTB_c34750 ENOG4105KVH Transcriptional regulator BTB_c34850 ENOG4105JAB phenazine biosynthesis protein, phzf family BTB_c34870 ENOG4105CHR reductase BTB_c34900 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BTB_c34910 ENOG4105KVH Transcriptional regulator BTB_c34940 ENOG4108ZJ4 polysaccharide deacetylase BTB_c35070 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BTB_c35100 ENOG4107YXZ hydrolase, family 25 BTB_c35170 ENOG4105H3G oxidoreductase BTB_c35300 ENOG4108TN2 lmbE family BTB_c35320 ENOG4107R3E Citrate transporter BTB_c35350 ENOG4108MES Periplasmic binding protein BTB_c35360 ENOG4105EHG Permease protein BTB_c35370 ENOG4105DQ5 transport system permease protein BTB_c35380 ENOG4105NX3 Membrane BTB_c35420 ENOG4107CUJ Protein of unknown function (DUF2690) BTB_c35440 ENOG4107V2S Transcriptional regulator BTB_c35480 ENOG4105C98 muts2 protein BTB_c35500 ENOG4105E5K Alpha-amylase BTB_c35510 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BTB_c35520 ENOG4105DPN Oligoendopeptidase f BTB_c35560 ENOG4105FFC UPF0187 protein BTB_c35590 ENOG4108A04 Beta-lactamase BTB_c35640 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BTB_c35660 ENOG41082BM Transcriptional regulator, arsr family BTB_c35670 ENOG4105CB2 alcohol dehydrogenase BTB_c35690 ENOG4107JM4 Tetratricopeptide repeat BTB_c35740 ENOG4105CQB FAD linked oxidase domain protein BTB_c35790 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BTB_c35800 ENOG4108M1A Chitin-binding protein BTB_c35820 ENOG4105E1K spore germination protein BTB_c35900 ENOG4105BZU Histidine kinase BTB_c35910 ENOG4105C5H ABC transporter BTB_c35920 ENOG41067SE Tetr family transcriptional regulator BTB_c35930 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BTB_c35950 ENOG4108VXD carboxy-peptidase BTB_c35960 ENOG4107DUR UPF0457 protein BTB_c36000 ENOG4105BZU Histidine kinase BTB_c36020 ENOG4105KT7 mgtC SapB transporter BTB_c36050 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BTB_c36060 ENOG4105EAB amino acid AbC transporter BTB_c36080 ENOG4108HW4 amino acid AbC transporter BTB_c36090 ENOG41073R8 VanW family BTB_c36110 ENOG4108R1P BTB_c36150 ENOG4105VEQ Cold shock protein BTB_c36190 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BTB_c36230 ENOG410904N short-chain dehydrogenase reductase BTB_c36250 ENOG4106IQC argininosuccinate lyase BTB_c36280 ENOG4108IA2 Sodium pantothenate symporter BTB_c36300 ENOG4105C26 Dehydrogenase BTB_c36310 ENOG4105CHR reductase BTB_c36330 ENOG4105EWU Squalene--hopene cyclase BTB_c36350 ENOG4105FR1 rard protein BTB_c36360 ENOG410696E Membrane BTB_c36390 ENOG4105D1F ATP-binding protein BTB_c36410 ENOG4108ZAF Molybdopterin BTB_c36420 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTB_c36430 ENOG4105D06 uba thif-type nad fad binding protein BTB_c36440 ENOG4105TMB Formate nitrite transporter BTB_c36460 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BTB_c36470 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BTB_c36490 ENOG4108JB9 formate dehydrogenase BTB_c36500 ENOG4105E1K spore germination protein BTB_c36540 ENOG4105CUB amino acid BTB_c36630 ENOG4105DQ6 Transposase BTB_c36670 ENOG4108KGH TRANSCRIPTIONal BTB_c36690 ENOG4105EMN RNA polymerase sigma factor BTB_c36720 ENOG4105CIG ABC transporter BTB_c36760 ENOG4105D9R oxidoreductase BTB_c36780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTB_c36790 ENOG4105K4P CoA-binding domain protein BTB_c36800 ENOG4105C0H protease BTB_c36810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c36830 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BTB_c36840 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BTB_c36850 ENOG4105W8X HesB YadR YfhF-family protein BTB_c36910 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BTB_c36920 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTB_c36940 ENOG4108JJA ABC, transporter BTB_c36950 ENOG4108I0Z Aconitate hydratase BTB_c37010 ENOG4105E5W Transporter BTB_c37030 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTB_c37070 ENOG4107F3J Amp-dependent synthetase and ligase BTB_c37080 ENOG4107ZYJ bioY protein BTB_c37090 ENOG4105CEY Amp-dependent synthetase and ligase BTB_c37100 ENOG4108IMY Transcriptional regulator BTB_c37170 ENOG4107AYK membrAne BTB_c37190 ENOG4105BZU Histidine kinase BTB_c37200 ENOG4105FBA Phospholipase Carboxylesterase BTB_c37210 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BTB_c37220 ENOG4105CK7 Sodium proline symporter BTB_c37230 ENOG4105CBC glutamate synthase BTB_c37240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BTB_c37250 ENOG4108VJ1 Transcriptional regulator (CarD family BTB_c37260 ENOG4108903 Formimidoylglutamase BTB_c37310 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BTB_c37370 ENOG4107QIV Cytochrome c biogenesis protein BTB_c37400 ENOG4105CH2 amidohydrolase BTB_c37420 ENOG4105CJ1 ABC, transporter BTB_c37460 ENOG4107RSM transcriptional regulator BTB_c37470 ENOG4105VAW lrga family BTB_c37480 ENOG41067MG lrgb family BTB_c37570 ENOG4105BZ1 (ABC) transporter BTB_c37580 ENOG4105BZ1 (ABC) transporter BTB_c37650 ENOG4108HW3 (ABC) transporter BTB_c37660 ENOG4105CGH 5'-nucleotidase BTB_c37680 ENOG4108SVB resolvase BTB_c37720 ENOG4105K7K Transcriptional regulator BTB_c37730 ENOG4105C5F glutamine synthetase BTB_c37740 ENOG4105KV4 Transcriptional regulator BTB_c37750 ENOG4105CXI aluminum resistance protein BTB_c37760 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BTB_c37770 ENOG4105EN6 Membrane BTB_c37790 ENOG4106F1P AAA ATPase, central domain protein BTB_c37820 ENOG4105DQ6 Transposase BTB_c37870 ENOG41069ER domain protein BTB_c37880 ENOG4105DM4 PTS System BTB_c37890 ENOG4105DE4 1-phosphofructokinase BTB_c37900 ENOG4105E98 transcriptional regulator DeoR family BTB_c37910 ENOG4107QW4 alcohol dehydrogenase BTB_c37920 ENOG4108SJC Membrane BTB_c37950 ENOG4105C85 amino acid BTB_c37980 ENOG4105TMB Formate nitrite transporter BTB_c37990 ENOG4105K70 DNA-binding protein BTB_c38010 ENOG4105C59 p-type ATPase BTB_c38020 ENOG410681U heavy metal transport detoxification protein BTB_c38030 ENOG4105VPX protein, conserved in bacteria BTB_c38070 ENOG4105NIV Esterase BTB_c38080 ENOG4105E0A ABC, transporter BTB_c38120 ENOG4105CGK Exodeoxyribonuclease III BTB_c38140 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BTB_c38150 ENOG4105D03 DNA-3-methyladenine glycosylase II BTB_c38210 ENOG4105BZU Histidine kinase BTB_c38280 ENOG41067MG lrgb family BTB_c38320 ENOG4108S3Y transcriptional regulator BTB_c38330 ENOG4105CS2 ec 3.2.1.21 BTB_c38360 ENOG4105F0V Cell wall hydrolase BTB_c38380 ENOG4105E0M Sulfatase BTB_c38390 ENOG410890F Dynamin family BTB_c38460 ENOG4105DQU oxidoreductase, subunit beta BTB_c38470 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BTB_c38480 ENOG4108IGT Dipeptidase BTB_c38490 ENOG4105MCT stage V sporulation protein S BTB_c38500 ENOG4105D48 metallophosphoesterase BTB_c38540 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BTB_c38570 ENOG4105XZV Protein of unknown function (DUF3243) BTB_c38580 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BTB_c38620 ENOG4105UIB (ABC) transporter BTB_c38630 ENOG4108JQ9 ABC transporter BTB_c38640 ENOG4105DIH basic membrane BTB_c38650 ENOG4105FDP GntR family transcriptional regulator BTB_c38670 ENOG4105CNU cell division protein FtsK BTB_c38690 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BTB_c38710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BTB_c38730 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BTB_c38800 ENOG41085W3 Transposase BTB_c39130 ENOG4105CDU Replicative dna helicase BTB_c39210 ENOG4108IMY Transcriptional regulator BTB_c39270 ENOG4108S0H Dipicolinic acid synthetase, b subunit BTB_c39280 ENOG4105E35 Dipicolinate synthase subunit A BTB_c39300 ENOG4105C1V Peptidase, M16 BTB_c39340 ENOG4105DTN riboflavin biosynthesis protein ribF BTB_c39370 ENOG4105W7A Protein of unknown function (DUF503) BTB_c39390 ENOG4105VHM ribosomal protein BTB_c39400 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BTB_c39410 ENOG4105CHV Transcription elongation factor NusA BTB_c39430 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BTB_c39450 ENOG4105DZP Membrane-associated zinc metalloprotease BTB_c39460 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BTB_c39470 ENOG4105KNE Phosphatidate cytidylyltransferase BTB_c39480 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BTB_c39500 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BTB_c39570 ENOG4108HE4 integrase family BTB_c39590 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BTB_c39600 ENOG4105C79 DNA protecting protein DprA BTB_c39610 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BTB_c39640 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BTB_c39690 ENOG4105VB6 UPF0109 protein BTB_c39730 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BTB_c39740 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BTB_c39770 ENOG4105CHR reductase BTB_c39780 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BTB_c39810 ENOG4105CB5 ATP-dependent DNA helicase recG BTB_c39820 ENOG4105DP4 dak2 domain fusion protein ylov BTB_c39830 ENOG4108ZAA Alkaline-shock protein BTB_c39850 ENOG4105FJ0 thiamine BTB_c39860 ENOG4105DJV ribulose-phosphate 3-epimerase BTB_c39870 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BTB_c39880 ENOG4105D9P serine threonine protein kinase BTB_c39890 ENOG4108ZF3 Phosphatase BTB_c39910 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BTB_c39940 ENOG4105C25 Primosomal protein n' BTB_c39950 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BTB_c39990 ENOG4105DSJ YicC domain protein BTB_c40010 ENOG4105F23 Fibronectin-binding protein BTB_c40030 ENOG4105DC7 peptidase M24 BTB_c40130 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BTB_c40200 ENOG4105C34 Pseudouridine synthase BTB_c40230 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BTB_c40250 ENOG4105DBK s4 domain protein BTB_c40260 ENOG41067XK integral membrane protein BTB_c40280 ENOG4105DFA alanine racemase domain protein BTB_c40290 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BTB_c40300 ENOG4105WR5 sporulation protein, YlmC YmxH family BTB_c40320 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_c40340 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BTB_c40350 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BTB_c40370 ENOG4105D4A Cell wall formation (By similarity) BTB_c40380 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BTB_c40390 ENOG4105CNI cell division protein FtsW BTB_c40420 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BTB_c40430 ENOG4105CJN penicillin-binding protein BTB_c40440 ENOG4105CJN penicillin-binding protein BTB_c40470 ENOG41074B2 UPF0747 protein BTB_c40520 ENOG4105KNH Nucleic acid-binding protein BTB_c40540 ENOG41063PX domain protein BTB_c40550 ENOG4105D78 K07001 NTE family protein BTB_c40560 ENOG4105H20 Sporulation integral membrane protein YlbJ BTB_c40580 ENOG4106H78 methyltransferase BTB_c40620 ENOG4107TB6 phosphoglycerate mutase BTB_c40650 ENOG4106UY4 Inherit from COG: Scp-like extracellular BTB_c40690 ENOG4105DQ6 Transposase BTB_c40710 ENOG4105EKQ RNA-directed DNA polymerase BTB_c40800 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BTB_c40810 ENOG4105CNI cell division protein FtsW BTB_c40840 ENOG4108IAB Phoh family BTB_c40880 ENOG4105QA2 BTB_c40890 ENOG4105CI3 gtp-binding protein typa BTB_c40910 ENOG4105ECY inositol monophosphatase BTB_c40950 ENOG4105CXN decarboxylase BTB_c41050 ENOG4105CPP Dehydrogenase, E1 component BTB_c41080 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BTB_c41090 ENOG4108X4Q Hydrolase BTB_c41110 ENOG4105CN5 Metallo-Beta-Lactamase BTB_c41120 ENOG4107ZYR domain protein BTB_c41190 ENOG4108XRC Protein of unknown function (DUF458) BTB_c41210 ENOG4107IN1 Protein of unknown function (DUF1797) BTB_c41240 ENOG4105EPM Diguanylate phosphodiesterase BTB_c41250 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BTB_c41280 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BTB_c41300 ENOG4105UIN BTB_c41370 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BTB_c41410 ENOG4108HGU Histidine kinase BTB_c41430 ENOG4105CHM Aminotransferase BTB_c41440 ENOG4105FKQ transcriptional regulator BTB_c41450 ENOG4105EG2 ABC transporter, permease BTB_c41470 ENOG4107FKK extracellular solute-binding protein family 1 BTB_c41490 ENOG4105CG3 alpha amylase, catalytic region BTB_c41580 ENOG4105CHU acetyl-coa acetyltransferase BTB_c41640 ENOG4105K7K Transcriptional regulator BTB_c41650 ENOG4105DTD Dehydrogenase BTB_c41690 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BTB_c41740 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BTB_c41770 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BTB_c41790 ENOG4105BZU Histidine kinase BTB_c41830 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BTB_c41860 ENOG4105CID antiterminator BTB_c41880 ENOG4105FDP GntR family transcriptional regulator BTB_c41900 ENOG4105CE4 GlcNAc 6-P deacetylase BTB_c41970 ENOG4107ZE5 PPIases accelerate the folding of proteins BTB_c41980 ENOG4105PTM secreted protein BTB_c41990 ENOG4105J7I hydrolase BTB_c42010 ENOG4105G6R Stage v sporulation protein ae BTB_c42030 ENOG4105CZ3 stage V sporulation protein ad BTB_c42040 ENOG41090VF Stage v sporulation protein ac BTB_c42080 ENOG4105C8J )-transporter BTB_c42090 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_c42110 ENOG41082AN stage II sporulation protein BTB_c42120 ENOG4105DZ1 carboxypeptidase BTB_c42130 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BTB_c42140 ENOG4105DVE abc transporter atp-binding protein BTB_c42210 ENOG4105D7N magnesium and cobalt transport protein CorA BTB_c42260 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTB_c42280 ENOG4105I3K Ferric uptake regulator, Fur family BTB_c42290 ENOG4105MZ9 stage II sporulation protein m BTB_c42330 ENOG4105CPC Aldo Keto reductase BTB_c42350 ENOG4105RHY Pfam:UPF0157 BTB_c42390 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BTB_c42410 ENOG4105ETE Transcriptional regulator (LacI family BTB_c42420 ENOG4108YM7 Gcn5-related n-acetyltransferase BTB_c42460 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BTB_c42470 ENOG4108R6K riboflavin synthase, subunit alpha BTB_c42520 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTB_c42530 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTB_c42560 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTB_c42580 ENOG4105DFD Na H antiporter BTB_c42590 ENOG4105CGH 5'-nucleotidase BTB_c42710 ENOG4105DBV ornithine carbamoyltransferase BTB_c42740 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BTB_c42770 ENOG4108IXY short-chain dehydrogenase reductase BTB_c42780 ENOG41069FQ Metallo-beta-lactamase superfamily BTB_c42790 ENOG4105II7 pyrroline-5-carboxylate reductase BTB_c42800 ENOG4105EJQ L-serine dehydratase BTB_c42850 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BTB_c42880 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BTB_c42890 ENOG4105D9U N-acetyltransferase BTB_c42910 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BTB_c42920 ENOG4108QEG Membrane BTB_c42930 ENOG4105CDA abc transporter atp-binding protein BTB_c42940 ENOG4105E5Q amino acid AbC transporter BTB_c42950 ENOG4108HW3 (ABC) transporter BTB_c42970 ENOG4105G7B Protein of unknown function (DUF2992) BTB_c42990 ENOG4108QY0 Membrane BTB_c43010 ENOG4105C7S Dehydrogenase BTB_c43020 ENOG4105CPP Dehydrogenase, E1 component BTB_c43050 ENOG4105CKM Branched-chain carboxylic acid kinase BTB_c43060 ENOG4107RDP Dehydrogenase BTB_c43080 ENOG4108JUB Transcriptional regulator BTB_c43100 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BTB_c43130 ENOG4107QQR Sporulation BTB_c43140 ENOG4105S1Z Stage IV sporulation protein B BTB_c43150 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BTB_c43160 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BTB_c43170 ENOG4105DX0 Hemolysin A BTB_c43190 ENOG4105CTB Polyprenyl synthetase BTB_c43220 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BTB_c43240 ENOG4108ZSR alkaline shock protein BTB_c43250 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BTB_c43300 ENOG410644B Stage III sporulation protein af BTB_c43320 ENOG4105KQ4 Stage iii sporulation protein ad BTB_c43330 ENOG4108CQH stage III sporulation protein AC BTB_c43340 ENOG4105KR5 Stage iii sporulation protein BTB_c43350 ENOG4105CD2 stage iii sporulation protein aa BTB_c43400 ENOG4105DC7 peptidase M24 BTB_c43410 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BTB_c43430 ENOG4105CBJ Metal-dependent enzyme BTB_c43450 ENOG4107YBY Hydrolase BTB_c43510 ENOG41082GG biotin lipoate A B protein ligase BTB_c43520 ENOG4105WZW rhodanese family BTB_c43570 ENOG41080TC multidrug resistance protein BTB_c43640 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BTB_c43700 ENOG4105C0D helicase BTB_c43870 ENOG4107R6U sodium dicarboxylate symporter BTB_c43940 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BTB_c43950 ENOG4105D7V transposase BTB_c43960 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BTB_c43970 ENOG4105C3R Methionine synthase BTB_c43990 ENOG4105C28 cystathionine BTB_c44000 ENOG4105C28 cystathionine BTB_c44040 ENOG4105C5X domain protein BTB_c44060 ENOG4105DKQ ROK family BTB_c44080 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BTB_c44110 ENOG4108UTW Plays a role in the regulation of phosphate uptake BTB_c44120 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BTB_c44130 ENOG4105C8U phosphate abc transporter BTB_c44140 ENOG4105C8U phosphate abc transporter BTB_c44150 ENOG4105EXS phosphate abc transporter BTB_c44160 ENOG4107RF6 penicillin-binding protein BTB_c44180 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTB_c44230 ENOG4105N80 Ferric uptake regulator, Fur family BTB_c44250 ENOG4105FDK ABC transporter BTB_c44260 ENOG4108JYZ YitT family BTB_c44270 ENOG41069ZM Protein of unknown function (DUF2624) BTB_c44320 ENOG4105EGD dinuclear metal center protein, YbgI family BTB_c44350 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_c44360 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BTB_c44410 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BTB_c44420 ENOG4105KG3 cytidine deaminase BTB_c44430 ENOG4107YR5 Diacylglycerol kinase BTB_c44440 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BTB_c44450 ENOG4105CTJ Metal Dependent Phosphohydrolase BTB_c44460 ENOG4105C9A Phoh family BTB_c44480 ENOG41068P3 sporulation protein YqfC BTB_c44500 ENOG4105KTH gatB Yqey BTB_c44520 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BTB_c44530 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BTB_c44590 ENOG4105CSA Coproporphyrinogen iii oxidase BTB_c44600 ENOG4105KVH Transcriptional regulator BTB_c44650 ENOG4105TQK DNA polymerase iii, delta' subunit BTB_c44670 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BTB_c44680 ENOG4108UK2 deaminase BTB_c44690 ENOG4105KQC Competence protein BTB_c44710 ENOG4105DXX methyltransferase BTB_c44730 ENOG4108WF2 Metal Dependent Phosphohydrolase BTB_c44750 ENOG410812S Rna-binding protein BTB_c44770 ENOG4105CQW ribosome biogenesis GTPase YqeH BTB_c44780 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BTB_c44810 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_c44850 ENOG4108TVJ Nitroreductase BTB_c44880 ENOG4105G6Z alkaline phosphatase BTB_c44890 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BTB_c44900 ENOG4108MUZ hydrolase BTB_c44970 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BTB_c44980 ENOG4105MIR Phenylalanine 4-monooxygenase BTB_c45000 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BTB_c45080 ENOG4105S6R Iron-hydroxamate transporter permease subunit BTB_c45090 ENOG4108V5C ABC transporter BTB_c45110 ENOG4108EKI Dehydrogenase BTB_c45120 ENOG4105C28 cystathionine BTB_c45180 ENOG4107XRG penicillin-binding protein BTB_c45190 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BTB_c45210 ENOG4105CFP Peptidase U32 BTB_c45220 ENOG4105XYU peptidase (U32 family) BTB_c45230 ENOG4108VQJ O-methyltransferase BTB_c45240 ENOG4105HHA aminodeoxychorismate lyase BTB_c45280 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTB_c45300 ENOG4105C02 permease BTB_c45330 ENOG41060CR BTB_c45340 ENOG4105C7H Helicase, RecD TraA family BTB_c45360 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BTB_c45370 ENOG4105C3J Cysteine desulfurase BTB_c45390 ENOG4105D1H recombination factor protein RarA BTB_c45400 ENOG4108VCI transcription factor, rsfa family BTB_c45410 ENOG4105CUZ uba thif-type nad fad binding protein BTB_c45430 ENOG4105CUT histidyl-tRNA synthetase BTB_c45450 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BTB_c45460 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BTB_c45480 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BTB_c45490 ENOG41076HS cation diffusion facilitator family transporter BTB_c45500 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BTB_c45520 ENOG4105CKP Polysaccharide Biosynthesis Protein BTB_c45530 ENOG4108QG2 Membrane BTB_c45550 ENOG4105VIE preprotein translocase, subunit YajC BTB_c45580 ENOG41061AI Protein of unknown function (DUF2905) BTB_c45610 ENOG4108HUF Transporter BTB_c45670 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BTB_c45680 ENOG4108IYU L-aspartate oxidase BTB_c45710 ENOG4108RPX mosc domain containing protein BTB_c45720 ENOG4105CQC Prephenate dehydratase BTB_c45750 ENOG4105C19 ABC transporter BTB_c45760 ENOG4105EWM Histidine kinase BTB_c45780 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BTB_c45810 ENOG4105X36 (ribosomal) protein BTB_c45830 ENOG4105C03 ribonuclease BTB_c45860 ENOG4107QMS site-determining protein BTB_c45890 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BTB_c45900 ENOG4105DFF Rod shape-determining protein mreb BTB_c45940 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BTB_c45950 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BTB_c45970 ENOG41068KH stage VI sporulation protein D BTB_c45990 ENOG4105D52 delta-aminolevulinic acid dehydratase BTB_c46040 ENOG4105K56 Transcriptional regulator BTB_c46080 ENOG4108IUQ atp-dependent protease BTB_c46140 ENOG4108QCI YvbH-like oligomerisation region BTB_c46400 ENOG4105M59 Phosphodiesterase, mj0936 family BTB_c46430 ENOG4108XJQ germination protein BTB_c46450 ENOG4108PCX Major Facilitator BTB_c46470 ENOG4105KBX Transcriptional regulator, TetR family BTB_c46490 ENOG4105PFC Transcriptional regulator BTB_c46510 ENOG4105DZC cytosine deaminase BTB_c46520 ENOG41067S9 phage shock protein C, PspC BTB_c46530 ENOG4108JCI Transcriptional regulator BTB_c46550 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BTB_c46560 ENOG4108Z40 Transcriptional regulator BTB_c46570 ENOG4105RHA ABC transporter, permease BTB_c46580 ENOG4108IUX (ABC) transporter BTB_c46590 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BTB_c46600 ENOG4105ER2 Ompa motb domain protein BTB_c46610 ENOG4105E14 MotA TolQ exbB proton channel BTB_c46620 ENOG4108VXD carboxy-peptidase BTB_c46640 ENOG4105E33 succinate dehydrogenase BTB_c46660 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BTB_c46680 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BTB_c46690 ENOG4105K63 Thioredoxin BTB_c46700 ENOG4105C10 Electron transfer flavoprotein BTB_c46710 ENOG4105BZJ Electron transfer flavoprotein BTB_c46720 ENOG41060WC Enoyl-CoA hydratase BTB_c46730 ENOG4107Z3H Transcriptional regulator, TetR family BTB_c46740 ENOG4105CEY Amp-dependent synthetase and ligase BTB_c46760 ENOG4105J76 Periplasmic binding protein BTB_c46770 ENOG4105S6R Iron-hydroxamate transporter permease subunit BTB_c46870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTB_c46900 ENOG4105DR4 Methyltransferase BTB_c46920 ENOG4105KFN sortase, SrtB family BTB_c46930 ENOG4105E0A ABC, transporter BTB_c46960 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BTB_c46970 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BTB_c46990 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BTB_c47010 ENOG4105FE9 pseudouridine synthase BTB_c47040 ENOG4105DCG PHP domain protein BTB_c47070 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BTB_c47100 ENOG4105C5S asparaginyl-tRNA synthetase BTB_c47110 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BTB_c47130 ENOG4108RWN rrna methyltransferase BTB_c47190 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTB_c47200 ENOG4105CW7 secretion protein, HlyD family BTB_c47210 ENOG4108JGH Tetr family transcriptional regulator BTB_c47220 ENOG4105CN9 Peptidase m42 family protein BTB_c47260 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BTB_c47270 ENOG4105C22 threonyL-tRNA synthetase BTB_c47280 ENOG4108TDW sporulation protein YtxC BTB_c47330 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BTB_c47340 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BTB_c47350 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BTB_c47370 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BTB_c47380 ENOG4105C2M dna polymerase I BTB_c47390 ENOG4105BZU Histidine kinase BTB_c47400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTB_c47450 ENOG4108HMX isocitrate dehydrogenase (NADP) BTB_c47460 ENOG4105BZN citrate synthase BTB_c47480 ENOG4108REF Sporulation integral membrane protein ytvi BTB_c47490 ENOG4105FS0 cytoplasmic membrane protein BTB_c47540 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BTB_c47550 ENOG4105C6K Malic enzyme BTB_c47560 ENOG4105C0B DNA polymerase III (alpha subunit) BTB_c47570 ENOG4105VV2 BTB_c47590 ENOG4105SFS phosphoesterase RecJ domain protein BTB_c47650 ENOG4105DC7 peptidase M24 BTB_c47720 ENOG4105Z7P Acetyltransferase (GNAT) family BTB_c47730 ENOG41082W1 Cupin 2, conserved barrel domain protein BTB_c47770 ENOG4107YZX Universal stress protein BTB_c47860 ENOG4108JYZ YitT family BTB_c47900 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BTB_c47920 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BTB_c47930 ENOG4105KBJ sporulation protein ytfj BTB_c47960 ENOG4105EFZ amidohydrolase BTB_c47980 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BTB_c48030 ENOG4105RQF LysR family Transcriptional regulator BTB_c48050 ENOG4105U5Y Transcriptional regulator BTB_c48070 ENOG4105C28 cystathionine BTB_c48130 ENOG4105EMN RNA polymerase sigma factor BTB_c48150 ENOG4108UW5 maltose o-acetyltransferase BTB_c48170 ENOG4105F1V Acetoin utilization protein BTB_c48180 ENOG4105W87 Cbs domain BTB_c48190 ENOG4105DGU Histone deacetylase BTB_c48200 ENOG4106HB6 Alpha beta hydrolase BTB_c48220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTB_c48230 ENOG4105BZU Histidine kinase BTB_c48240 ENOG4107SNB ankyrin repeat protein YahD BTB_c48250 ENOG4105EP9 oxidoreductase BTB_c48300 ENOG4105ETE Transcriptional regulator (LacI family BTB_c48310 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BTB_c48350 ENOG4105C88 aminopeptidase BTB_c48390 ENOG4108IPJ Membrane BTB_c48460 ENOG4108VDD TRNA binding domain protein BTB_c48520 ENOG4105C8F Beta-lactamase domain protein BTB_c48550 ENOG4108V15 phosphotransferase enzyme family BTB_c48560 ENOG4108IUM Glycogen debranching enzyme BTB_c48580 ENOG4107QSE Dipeptidase BTB_c48590 ENOG4105YW5 deoR family transcriptional regulator BTB_c48620 ENOG4105CBX hi0933 family BTB_c48690 ENOG4108VJ1 Transcriptional regulator (CarD family BTB_c48700 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BTB_c48710 ENOG4105CSC Glucose uptake protein BTB_c48740 ENOG4108ZAF Molybdopterin BTB_c48750 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BTB_c48760 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTB_c48780 ENOG4105D06 uba thif-type nad fad binding protein BTB_c48790 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BTB_c48840 ENOG41085GJ domain protein BTB_c48860 ENOG4105DWV Homoserine O-trans-acetylase BTB_c48880 ENOG4108B31 Spore germination protein BTB_c48930 ENOG4105C8T Leucyl-tRNA synthetase BTB_c48940 ENOG410605W Major Facilitator BTB_c48950 ENOG4107S91 Sodium hydrogen exchanger BTB_c48960 ENOG4105NCW Trka-c domain protein BTB_c48990 ENOG4105C19 ABC transporter BTB_c49010 ENOG4105D7V transposase BTB_c49040 ENOG4105N5T Radical SAM Protein BTB_c49060 ENOG4105DA5 (ABC) transporter BTB_c49120 ENOG4105E8V Alpha Beta Hydrolase Fold protein BTB_c49130 ENOG4108Z0R Transferase BTB_c49140 ENOG4105YVM Phosphoesterase, PA-phosphatase related BTB_c49150 ENOG4105BZF Glycosyl transferase (Group 1 BTB_c49170 ENOG4105EPU Molybdenum cofactor synthesis domain protein BTB_c49310 ENOG4105BZU Histidine kinase BTB_c49320 ENOG4105BZU Histidine kinase BTB_c49330 ENOG4105CH6 catalase BTB_c49340 ENOG4107S9D Alpha beta hydrolase BTB_c49350 ENOG4107T7U Sulfatase BTB_c49390 ENOG4105D2X ABC transporter substrate-binding protein BTB_c49410 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BTB_c49520 ENOG41080TC multidrug resistance protein BTB_c49530 ENOG410839T multidrug resistance protein BTB_c49570 ENOG4108V2W Carbonate dehydratase BTB_c49580 ENOG4105C4M (Ubiquinol oxidase) subunit I BTB_c49590 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BTB_c49660 ENOG41087YS Phage shock protein A BTB_c49710 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BTB_c49720 ENOG4105BZU Histidine kinase BTB_c49730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c49780 ENOG4108UGV hypoxanthine phosphoribosyltransferase BTB_c49790 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BTB_c49820 ENOG4105C19 ABC transporter BTB_c49850 ENOG4107ZTW SNARE associated Golgi BTB_c49880 ENOG4105C19 ABC transporter BTB_c49890 ENOG41086D8 Transcriptional regulator BTB_c49920 ENOG41082BM Transcriptional regulator, arsr family BTB_c50020 ENOG4105C6Z Gluconate BTB_c50030 ENOG4105FDP GntR family transcriptional regulator BTB_c50070 ENOG41069H0 dihydroorotase EC 3.5.2.3 BTB_c50120 ENOG4105DTQ mandelate racemase muconate lactonizing BTB_c50130 ENOG4105CEY Amp-dependent synthetase and ligase BTB_c50140 ENOG4108IPT Naphthoate synthase BTB_c50150 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BTB_c50160 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BTB_c50170 ENOG4105E4F Isochorismate synthase BTB_c50180 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BTB_c50200 ENOG4105VEQ Cold shock protein BTB_c50290 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BTB_c50300 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BTB_c50320 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BTB_c50590 ENOG4105KT7 mgtC SapB transporter BTB_c50600 ENOG4107PBV potassium channel BTB_c50630 ENOG4105WG9 Conserved Protein BTB_c50650 ENOG4105CHM Aminotransferase BTB_c50660 ENOG4108ZB6 transcriptional regulator AsnC family BTB_c50670 ENOG4105C5I Dehydrogenase BTB_c50680 ENOG4108MUZ hydrolase BTB_c50700 ENOG4105C87 Aminotransferase class I and II BTB_c50730 ENOG4105Y38 Kinase-associated protein B BTB_c50750 ENOG4107R3E Citrate transporter BTB_c50780 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BTB_c50790 ENOG4105KA0 thioesterase Superfamily protein BTB_c50820 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BTB_c50870 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BTB_c50880 ENOG4106YN8 Prenyltransferase BTB_c50900 ENOG41069ER domain protein BTB_c50930 ENOG4105CEP NADH dehydrogenase BTB_c51020 ENOG4105EWC Purine nucleoside phosphorylase BTB_c51130 ENOG4105XSJ toxin secretion phage lysis holin BTB_c51410 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_c51460 ENOG4108ZUE Phage regulatory protein rha BTB_c51520 ENOG4108IMY Transcriptional regulator BTB_c51590 ENOG4108VQJ O-methyltransferase BTB_c51630 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BTB_c51670 ENOG4105C4B ABC transporter, permease BTB_c51680 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BTB_c51730 ENOG41083MR nifu domain-containing protein BTB_c51760 ENOG4108W5N phosphatidylglycerophosphatase a BTB_c51800 ENOG4105DAX Pfam:DUF2983 BTB_c51820 ENOG4105DYS nad(p)h dehydrogenase (quinone) BTB_c51830 ENOG4105D4U had-superfamily hydrolase, subfamily iia BTB_c51860 ENOG4105CBT Fructose-1,6-bisphosphatase BTB_c51900 ENOG4105MMD transcriptional regulator BTB_c51910 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BTB_c51920 ENOG4107TXC Transcriptional regulator BTB_c51930 ENOG41090T1 Membrane BTB_c51980 ENOG4105FAA peptidase M23 BTB_c51990 ENOG4108YTE sporulation protein YunB BTB_c52000 ENOG4105KZD Domain of unknown function (DUF1805) BTB_c52010 ENOG4107R8B 5'-nucleotidase BTB_c52020 ENOG4105DIW FeS assembly protein SUFB BTB_c52030 ENOG4108UNV SUF system FeS assembly protein, NifU family BTB_c52040 ENOG4105C9B Cysteine desulfurase BTB_c52050 ENOG4105JRK feS assembly protein SufD BTB_c52060 ENOG4105C3K feS assembly ATPase SufC BTB_c52070 ENOG4105D01 (LipO)protein BTB_c52080 ENOG4105D01 (LipO)protein BTB_c52090 ENOG4108UMI ABC transporter, permease BTB_c52100 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTB_c52150 ENOG41080E8 Transcriptional regulator, Spx MgsR family BTB_c52230 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BTB_c52290 ENOG4108W8B Beta-lactamase domain protein BTB_c52300 ENOG4105C1G acyl-Coa dehydrogenase BTB_c52310 ENOG4105CHU acetyl-coa acetyltransferase BTB_c52340 ENOG4105DZ1 carboxypeptidase BTB_c52380 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTB_c52410 ENOG4108SUT Major Facilitator Superfamily BTB_c52420 ENOG4107R7I amino acid BTB_c52450 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BTB_c52470 ENOG4107AYK membrAne BTB_c52540 ENOG4107ZTW SNARE associated Golgi BTB_c52560 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BTB_c52570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c52580 ENOG4105BZU Histidine kinase BTB_c52630 ENOG4105C8Q Methyl-accepting chemotaxis BTB_c52640 ENOG4105C8Q Methyl-accepting chemotaxis BTB_c52650 ENOG4105VG1 fes assembly suf system protein BTB_c52660 ENOG4105D4Y metalloprotease BTB_c52670 ENOG4105C2I pirin domain protein BTB_c52700 ENOG4107T5V SNARE associated Golgi BTB_c52710 ENOG4107S91 Sodium hydrogen exchanger BTB_c52720 ENOG4105NCW Trka-c domain protein BTB_c52740 ENOG4108RMU ferritin dps family protein BTB_c52780 ENOG4108URH decarboxylase BTB_c52800 ENOG41090A1 ferritin BTB_c52820 ENOG4105D9N nucleoside BTB_c52830 ENOG4105D9N nucleoside BTB_c52860 ENOG4108RYK Nad-dependent epimerase dehydratase BTB_c52890 ENOG4105CV8 reductase BTB_c52900 ENOG4105F27 Major Facilitator BTB_c52910 ENOG4105KVH Transcriptional regulator BTB_c52940 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BTB_c52950 ENOG4105D4A Cell wall formation (By similarity) BTB_c53000 ENOG4105WMR Protein CrcB homolog BTB_c53010 ENOG4105WMR Protein CrcB homolog BTB_c53040 ENOG4108MK9 spermidine N(1)-acetyltransferase BTB_c53050 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BTB_c53070 ENOG4108W2Y isochorismatase BTB_c53130 ENOG4108IPW abc transporter atp-binding protein BTB_c53140 ENOG4105CM4 permease protein BTB_c53200 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BTB_c53220 ENOG4105XZU Preprotein translocase, subunit SecG BTB_c53230 ENOG41067MG lrgb family BTB_c53330 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_c53350 ENOG4105BZU Histidine kinase BTB_c53360 ENOG4108W5X Transcriptional Regulator, LuxR family BTB_c53400 ENOG41090VF Stage v sporulation protein ac BTB_c53410 ENOG4105CZ3 stage V sporulation protein ad BTB_c53440 ENOG4108QY0 Membrane BTB_c53450 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BTB_c53460 ENOG4105KRI phosphocarrier protein (HPr BTB_c53480 ENOG4105CHW UPF0052 protein BTB_c53490 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BTB_c53500 ENOG4108Z4K mutator MutT protein BTB_c53520 ENOG4105C3M thioredoxin reductase BTB_c53540 ENOG4108S4C acetyltransferase BTB_c53580 ENOG41086DT Membrane protein of unknown function BTB_c53600 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BTB_c53640 ENOG4107TXC Transcriptional regulator BTB_c53680 ENOG4105DUM transcriptional regulator, lysR family BTB_c53700 ENOG4108WS4 fmn reductase BTB_c53710 ENOG4105C5H ABC transporter BTB_c53730 ENOG4105BZ1 (ABC) transporter BTB_c53750 ENOG4105CN1 protease BTB_c53760 ENOG4105CRP Part of the ABC transporter FtsEX involved in BTB_c53770 ENOG4105CAK Cell division ATP-binding protein ftsE BTB_c53790 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BTB_c53810 ENOG4105MS2 ribosomal subunit Interface protein BTB_c53820 ENOG4105VEQ Cold shock protein BTB_c53830 ENOG41081UC Inherit from COG: Competence protein BTB_c53860 ENOG4105KVH Transcriptional regulator BTB_c53880 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BTB_c53890 ENOG4108KGH TRANSCRIPTIONal BTB_c53900 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BTB_c53910 ENOG4105C6Y Udp-glucose 6-dehydrogenase BTB_c53920 ENOG4105ESV Glycosyl transferase, family 4 BTB_c53940 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BTB_c53980 ENOG4105F8D glycoside hydrolase family 4 BTB_c53990 ENOG4105VCP PTS System BTB_c54000 ENOG4105CK1 PTS System BTB_c54020 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BTB_c54030 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BTB_c54040 ENOG4105VCP PTS System BTB_c54060 ENOG4105VZJ PTS System BTB_c54100 ENOG4105ECB domain protein BTB_c54110 ENOG4107RSM transcriptional regulator BTB_c54210 ENOG4105DAA L-lactate BTB_c54230 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BTB_c54250 ENOG4105E0M Sulfatase BTB_c54310 ENOG4107R8N Glycosyl transferase, family 2 BTB_c54330 ENOG4105C94 Transporter BTB_c54340 ENOG41069ER domain protein BTB_c54390 ENOG4105KBK Zinc finger, swim domain protein BTB_c54400 ENOG4105C0D helicase BTB_c54420 ENOG41085W3 Transposase BTB_c54470 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTB_c54490 ENOG4107RBB ABC transporter, permease BTB_c54500 ENOG4105C19 ABC transporter BTB_c54540 ENOG4105CXY transporter BTB_c54570 ENOG4105BZU Histidine kinase BTB_c54580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c54590 ENOG4105DG6 mannose-6-phosphate isomerase BTB_c54600 ENOG4105DM4 PTS System BTB_c54620 ENOG4105CMR udp-glucose 4-epimerase BTB_c54640 ENOG4108KGH TRANSCRIPTIONal BTB_c54650 ENOG4105DG6 mannose-6-phosphate isomerase BTB_c54660 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BTB_c54680 ENOG4107T8Q Glycosyl transferase (Group 1 BTB_c54690 ENOG4107EF8 Glycosyl transferase (Group 1 BTB_c54710 ENOG4107RA4 Glycosyl transferase (Group 1 BTB_c54720 ENOG4108UW5 maltose o-acetyltransferase BTB_c54750 ENOG4105D3Q Sugar transferase BTB_c54760 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BTB_c54770 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BTB_c54780 ENOG4107YJ4 chain length determinant protein BTB_c54790 ENOG4105HTX biosynthesis protein BTB_c54800 ENOG4107YJ4 chain length determinant protein BTB_c54830 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BTB_c54840 ENOG4105FRN stage II sporulation protein BTB_c54870 ENOG4105DY9 regulatoR BTB_c54910 ENOG4106778 Protein of unknown function (DUF1146) BTB_c54920 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BTB_c54930 ENOG4105C8S subunit m BTB_c54940 ENOG4105D65 subunit l BTB_c54990 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BTB_c55000 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BTB_c55020 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BTB_c55030 ENOG4105BZU Histidine kinase BTB_c55130 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BTB_c55140 ENOG41062M3 atp synthase BTB_c55170 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BTB_c55180 ENOG4108UIC UPF0340 protein BTB_c55190 ENOG4108YZG isomerase BTB_c55220 ENOG4108VGI doxx family BTB_c55230 ENOG4107XC4 flavin reductase domain protein, FMN-binding BTB_c55270 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BTB_c55290 ENOG4108ZXQ stage ii sporulation protein r BTB_c55300 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BTB_c55310 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BTB_c55340 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BTB_c55350 ENOG4105CBT Fructose-1,6-bisphosphatase BTB_c55360 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BTB_c55400 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BTB_c55430 ENOG4105C1G acyl-Coa dehydrogenase BTB_c55440 ENOG4105C1G acyl-Coa dehydrogenase BTB_c55450 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BTB_c55470 ENOG4105DF6 Fe-S oxidoreductase BTB_c55500 ENOG4105BZU Histidine kinase BTB_c55530 ENOG4105D4Y metalloprotease BTB_c55550 ENOG4105BZU Histidine kinase BTB_c55560 ENOG4105KCT ABC transporter BTB_c55570 ENOG4108M15 ABC transporter BTB_c55580 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BTB_c55600 ENOG4105IIU Aminopeptidase BTB_c55640 ENOG4105EMN RNA polymerase sigma factor BTB_c55660 ENOG410684U Domain of unknown function (DUF1934) BTB_c55700 ENOG4105CYW agmatinase BTB_c55720 ENOG4105DXB Major Facilitator superfamily BTB_c55730 ENOG4107SWG transcriptional regulator MERR family BTB_c55740 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BTB_c55750 ENOG4105BZ4 penicillin-binding protein BTB_c55760 ENOG4108XFG YwhD family BTB_c55770 ENOG4108Z4T Peptidase M50 BTB_c55780 ENOG41069HH 4-oxalocrotonate tautomerase BTB_c55790 ENOG4105DCI Phosphohydrolase BTB_c55800 ENOG4108MES Periplasmic binding protein BTB_c55810 ENOG4105E0A ABC, transporter BTB_c55820 ENOG4105EHG Permease protein BTB_c55830 ENOG4105DQ5 transport system permease protein BTB_c55850 ENOG4108VCI transcription factor, rsfa family BTB_c55860 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BTB_c55870 ENOG4108IJ2 phosphate acetyltransferase BTB_c55880 ENOG4107UEZ chlorite dismutase BTB_c55900 ENOG4108VKI Cell wall hydrolase BTB_c55940 ENOG4107SVH Potassium channel protein BTB_c55960 ENOG410667J hydrolase BTB_c55970 ENOG4105VCH membrane BTB_c55990 ENOG4108TU7 Inherit from COG: (ABC) transporter BTB_c56000 ENOG4105CJ1 ABC, transporter BTB_c56010 ENOG41090WU lipolytic protein G-D-S-L family BTB_c56040 ENOG4105D6E homoserine dehydrogenase BTB_c56050 ENOG4105CVG Homoserine O-transsuccinylase BTB_c56090 ENOG4108Y4K DNA-binding transcriptional activator BTB_c56110 ENOG4105WH1 Two component transcriptional regulator luxr family BTB_c56120 ENOG4105BZU Histidine kinase BTB_c56130 ENOG4105DWF phosphomethylpyrimidine kinase BTB_c56140 ENOG4105BZU Histidine kinase BTB_c56150 ENOG4105VCD cytoplasmic protein BTB_c56160 ENOG4105D22 carbon starvation protein BTB_c56170 ENOG4105DY9 regulatoR BTB_c56180 ENOG41079KZ Major Facilitator Superfamily BTB_c56200 ENOG4105CG5 Glycosyl transferase (Group 1 BTB_c56220 ENOG4105EN6 Membrane BTB_c56230 ENOG4106YBV Methyl-accepting chemotaxis BTB_c56250 ENOG4108S4H thioesterase Superfamily protein BTB_c56260 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BTB_c56280 ENOG4105K64 Glycosyl transferase, family 2 BTB_c56300 ENOG4105EJV Membrane BTB_c56310 ENOG4105CKK Glycosyl transferase, family 2 BTB_c56330 ENOG4108IG5 Transcriptional regulator BTB_c56340 ENOG4105C5H ABC transporter BTB_c56350 ENOG41067SE Tetr family transcriptional regulator BTB_c56370 ENOG4105E0X reductase BTB_c56380 ENOG4106F5Q Membrane BTB_c56410 ENOG4108NEV two component transcriptional regulator, LytTR family BTB_c56420 ENOG4108HRK Histidine kinase BTB_c56430 ENOG4107RGD Major Facilitator superfamily BTB_c56460 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTB_c56480 ENOG4105IW1 AmiS UreI transporter BTB_c56490 ENOG4105CMR udp-glucose 4-epimerase BTB_c56500 ENOG4108UT2 hemolysin iii BTB_c56520 ENOG4105C1J atp-dependent rna helicase BTB_c56540 ENOG4105DPN Oligoendopeptidase f BTB_c56560 ENOG4105BZU Histidine kinase BTB_c56590 ENOG4105C0H protease BTB_c56600 ENOG4105Q2H domain protein BTB_c56630 ENOG4105BZU Histidine kinase BTB_c56640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTB_c56690 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BTB_c56700 ENOG4105CDU Replicative dna helicase BTB_c56720 ENOG4105BZR domain protein BTB_c56730 ENOG4108XMW Membrane BTB_c56750 ENOG4108UUM single-stranded DNA-binding protein BTB_c56770 ENOG4105C3G gtp-binding protein BTB_c56780 ENOG4105VDK protein, conserved in bacteria BTB_c56790 ENOG4105D8X mechanosensitive ion channel BTB_c56800 ENOG4108ZDA Sporulation protein YyaC BTB_c56810 ENOG4105FA0 parb-like partition protein BTB_c56820 ENOG4107QJE Chromosome Partitioning Protein BTB_c56850 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BTB_c56860 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BTB_c56880 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins