locus-tag class description ATN06_00020 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ATN06_00055 ENOG4105ZMH deoxynucleoside kinase ATN06_00065 ENOG4105GTG Isochorismatase ATN06_00075 ENOG4108Z6B deaminase ATN06_00080 ENOG4105C6E dna polymerase iii ATN06_00100 ENOG41067KS pro-sigma K processing ATN06_00125 ENOG4105CXN decarboxylase ATN06_00135 ENOG4105FA2 dna polymerase iii ATN06_00140 ENOG4105MA4 psp1 domain protein ATN06_00150 ENOG41060K3 Methyltransferase ATN06_00160 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ATN06_00165 ENOG4105KRN Transcriptional regulator, abrb family ATN06_00170 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ATN06_00175 ENOG4105F8V Hydrolase, tatD family ATN06_00180 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) ATN06_00185 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ATN06_00190 ENOG4105XFA sporulation peptidase YabG ATN06_00195 ENOG4105W42 Veg protein ATN06_00210 ENOG4105DFT pur operon repressor ATN06_00215 ENOG4105KME endoribonuclease L-psp ATN06_00230 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ATN06_00245 ENOG4108JA2 transcriptioN-repair coupling factor ATN06_00250 ENOG4108M14 stage v sporulation protein t ATN06_00260 ENOG4108IY2 MazG family ATN06_00265 ENOG41082I2 s4 domain protein ATN06_00270 ENOG4105VYY sporulation protein yabp ATN06_00285 ENOG41060GV RNA binding s1 domain protein ATN06_00310 ENOG4108UGV hypoxanthine phosphoribosyltransferase ATN06_00315 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ATN06_00330 ENOG4105C6T cysteine synthase ATN06_00335 ENOG4105CRQ synthase (Component I) ATN06_00340 ENOG4105DDQ anthranilate synthase ATN06_00345 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 ATN06_00350 ENOG4105EEI dihydropteroate synthase ATN06_00355 ENOG4105KRF dihydroneopterin aldolase ATN06_00360 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ATN06_00370 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ATN06_00400 ENOG4108Z0C Uvrb UvrC protein ATN06_00415 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ATN06_00425 ENOG4105CTP PilT protein domain protein ATN06_00445 ENOG4105D7W serine acetyltransferase ATN06_00460 ENOG4105C2N RNA methyltransferase TrmH family group 3 ATN06_00465 ENOG4105M0M Tetracycline resistance protein ATN06_00470 ENOG4105QIV RNA polymerase ATN06_00485 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ATN06_00510 ENOG4107Y49 methyltransferase ATN06_00525 ENOG4105XPM ribosomal protein ATN06_00630 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ATN06_00645 ENOG4105VPB 50S ribosomal protein L30 ATN06_00655 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ATN06_00665 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ATN06_00675 ENOG41067V7 50S ribosomal protein L36 ATN06_00710 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) ATN06_00740 ENOG4105D1F ATP-binding protein ATN06_00755 ENOG4108NMV polysaccharide deacetylase ATN06_00835 ENOG4105C8B TIGR00159 family ATN06_00840 ENOG4107U5W ybbr family ATN06_00855 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ATN06_00860 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein ATN06_00875 ENOG4108PSK reductase ATN06_00880 ENOG4108UMI ABC transporter, permease ATN06_00885 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ATN06_00890 ENOG4105D01 (LipO)protein ATN06_00895 ENOG4105EE1 crotonyl-CoA reductase ATN06_00905 ENOG4105IQ5 FAD linked oxidase domain protein ATN06_00920 ENOG4105C2C drug resistance transporter, Bcr CflA ATN06_00935 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ATN06_00940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ATN06_00945 ENOG4105C3U ABC transporter ATN06_00950 ENOG4108JQ7 (ABC) transporter ATN06_00975 ENOG4105U5Y Transcriptional regulator ATN06_00985 ENOG4108J59 Extracellular solute-binding protein, family 5 ATN06_00990 ENOG4108J59 Extracellular solute-binding protein, family 5 ATN06_01010 ENOG4105E0C molybdate abc transporter ATN06_01015 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ATN06_01020 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family ATN06_01050 ENOG4105F6E Acyl-transferase ATN06_01070 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) ATN06_01095 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) ATN06_01120 ENOG4105C5H ABC transporter ATN06_01125 ENOG4105BZU Histidine kinase ATN06_01130 ENOG4105WH1 Two component transcriptional regulator luxr family ATN06_01135 ENOG4105CJ1 ABC, transporter ATN06_01140 ENOG41090VJ ABC-2 type transporter ATN06_01145 ENOG4108KYE ABC-2 type transporter ATN06_01155 ENOG4105DEF Extracellular solute-binding protein, family 5 ATN06_01160 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein ATN06_01170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ATN06_01175 ENOG4105C3U ABC transporter ATN06_01180 ENOG4108JQ7 (ABC) transporter ATN06_01185 ENOG410667J hydrolase ATN06_01210 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase ATN06_01215 ENOG4105ERH Fumarylacetoacetate hydrolase ATN06_01225 ENOG4105CUB amino acid ATN06_01230 ENOG4108SC4 )-transporter ATN06_01235 ENOG4105CPF Cell wall formation (By similarity) ATN06_01240 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) ATN06_01265 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein ATN06_01270 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ATN06_01280 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) ATN06_01385 ENOG4105K8N protein family UPF0079, ATPase ATN06_01390 ENOG41072GX Peptidase M22 Glycoprotease ATN06_01395 ENOG410801F ribosomal-protein-alanine acetyltransferase ATN06_01405 ENOG4105C5H ABC transporter ATN06_01420 ENOG4108TYN CAAX amino terminal protease family protein ATN06_01430 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ATN06_01440 ENOG4105C7N Xanthine uracil vitamin C permease ATN06_01450 ENOG4105BZU Histidine kinase ATN06_01475 ENOG4107ZXU DSBA oxidoreductase ATN06_01505 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ATN06_01525 ENOG4108SHN Glycosyl transferase, family 2 ATN06_01555 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ATN06_01560 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ATN06_01565 ENOG4105C83 adenylosuccinate lyase ATN06_01575 ENOG4105VR9 phosphoribosylformylglycinamidine synthase ATN06_01600 ENOG4108V3E phosphoribosylglycinamide formyltransferase ATN06_01610 ENOG4105C12 Phosphoribosylglycinamide synthetase ATN06_01640 ENOG4105C4R Atp-dependent dna helicase ATN06_01645 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ATN06_01670 ENOG4108W2Y isochorismatase ATN06_01680 ENOG4108UMI ABC transporter, permease ATN06_01685 ENOG4105D01 (LipO)protein ATN06_01705 ENOG410834F Transcriptional regulator ATN06_01710 ENOG4107I77 yiaA/B two helix domain ATN06_01730 ENOG4105CBD Diacylglycerol kinase ATN06_01740 ENOG4108JPW Aminotransferase ATN06_01750 ENOG4105C26 Dehydrogenase ATN06_01755 ENOG4105KPY Small multidrug resistance protein ATN06_01775 ENOG4105D9N nucleoside ATN06_01780 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ATN06_01790 ENOG4105BZU Histidine kinase ATN06_01795 ENOG4108W15 Protein of unknown function (DUF1456) ATN06_01810 ENOG4105DTQ mandelate racemase muconate lactonizing ATN06_01820 ENOG4105DFD Na H antiporter ATN06_01840 ENOG4105D3R alkyl hydroperoxide reductase ATN06_01845 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) ATN06_01850 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) ATN06_01855 ENOG4107W7X Aldolase ATN06_01860 ENOG4105EHG Permease protein ATN06_01865 ENOG4105DQ5 transport system permease protein ATN06_01870 ENOG4108V5C ABC transporter ATN06_01895 ENOG4106UIA ATN06_01900 ENOG4106UIA ATN06_01915 ENOG4105BZU Histidine kinase ATN06_01935 ENOG410756H nucleotidyltransferase ATN06_01940 ENOG4105D2S major facilitator superfamily ATN06_01955 ENOG4105E5Q amino acid AbC transporter ATN06_01960 ENOG4105EAB amino acid AbC transporter ATN06_01970 ENOG4105C8Q Methyl-accepting chemotaxis ATN06_01975 ENOG4105DNP FAD linked oxidase domain protein ATN06_01985 ENOG4105CI1 PTS System ATN06_02015 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ATN06_02030 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ATN06_02045 ENOG4105C5H ABC transporter ATN06_02075 ENOG41062JF Transcriptional regulator ATN06_02095 ENOG4105DEU major facilitator superfamily ATN06_02125 ENOG4108N0M stress protein ATN06_02130 ENOG4106FN3 tellurium resistance protein ATN06_02135 ENOG4106FN3 tellurium resistance protein ATN06_02140 ENOG4107TS3 membrane protein, TerC ATN06_02145 ENOG4108TTB tellurium resistance protein ATN06_02165 ENOG4105KJF protein tyrosine phosphatase ATN06_02175 ENOG4107U9T Pfam:Ribonuclease_BN ATN06_02180 ENOG4105C59 p-type ATPase ATN06_02185 ENOG4108IPJ Membrane ATN06_02200 ENOG4105C3F Signal peptidase i ATN06_02210 ENOG4107ZTW SNARE associated Golgi ATN06_02225 ENOG410606W general stress protein ATN06_02230 ENOG4105UPD Calcium Proton ATN06_02270 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ATN06_02280 ENOG4108JUB Transcriptional regulator ATN06_02290 ENOG4108IQI permease ATN06_02325 ENOG4105CSV Glutaminase ATN06_02335 ENOG4108A04 Beta-lactamase ATN06_02355 ENOG4107R51 Glycosyl transferase, family 2 ATN06_02360 ENOG4107QQG Dehydrogenase ATN06_02365 ENOG4105C3I Nad-dependent epimerase dehydratase ATN06_02370 ENOG4105CKK Glycosyl transferase, family 2 ATN06_02385 ENOG4105F1A Pyruvate formate-lyase ATN06_02405 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) ATN06_02410 ENOG4105ECP epimerase ATN06_02440 ENOG41067AE Membrane-bound metal-dependent hydrolase ATN06_02445 ENOG4105CEN a g-specific adenine glycosylase ATN06_02450 ENOG4106BXE ATN06_02470 ENOG4105BZ1 (ABC) transporter ATN06_02475 ENOG4107NBY Membrane ATN06_02480 ENOG4105CBC glutamate synthase ATN06_02490 ENOG4108IUW ABC transporter ATN06_02510 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ATN06_02515 ENOG4105G5W regulator Fur family ATN06_02630 ENOG4108JQC penicillin-binding protein 1A ATN06_02635 ENOG4107ZQN disulfide bond ATN06_02645 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ATN06_02655 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ATN06_02670 ENOG4105CYN Serine protein kinase ATN06_02695 ENOG4105C94 Transporter ATN06_02710 ENOG4105DZ6 Band 7 protein ATN06_02720 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ATN06_02725 ENOG4108V9W transcriptional regulatory protein ATN06_02730 ENOG4105D4T Citrate transporter ATN06_02755 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator ATN06_02760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ATN06_02765 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component ATN06_02770 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component ATN06_02775 ENOG4105BZ7 extracellular solute-binding protein family 1 ATN06_02780 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) ATN06_02785 ENOG4108STX response regulator ATN06_02790 ENOG4105US7 Histidine kinase ATN06_02815 ENOG4108MRH transcriptional regulatory protein ATN06_02825 ENOG4105C6K Malic enzyme ATN06_02835 ENOG4108UZ3 Transporter ATN06_02840 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ATN06_02850 ENOG4105BZU Histidine kinase ATN06_02855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_02865 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ATN06_02870 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ATN06_02875 ENOG4108JB9 formate dehydrogenase ATN06_02895 ENOG4105CUB amino acid ATN06_02905 ENOG4105C59 p-type ATPase ATN06_02910 ENOG4105DAP Nicotinate phosphoribosyltransferase ATN06_02940 ENOG41073R8 VanW family ATN06_02945 ENOG4108KGH TRANSCRIPTIONal ATN06_02950 ENOG4105D9N nucleoside ATN06_02955 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ATN06_02960 ENOG4105C37 (CBS) domain ATN06_02965 ENOG4108IJ0 Aspartate ammonia-lyase ATN06_02970 ENOG4105DAA L-lactate ATN06_02985 ENOG4105DUX Transporter ATN06_02990 ENOG4108MES Periplasmic binding protein ATN06_02995 ENOG4105DQ5 transport system permease protein ATN06_03000 ENOG4108IHU transport system permease protein ATN06_03005 ENOG4105E0A ABC, transporter ATN06_03010 ENOG4105DMQ Methyltransferase ATN06_03020 ENOG4105EXW epimerase dehydratase ATN06_03025 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ATN06_03035 ENOG4107T89 von Willebrand factor, type A ATN06_03040 ENOG4105GMT ATPase associated with various cellular activities aaa_5 ATN06_03045 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ATN06_03055 ENOG4105BZU Histidine kinase ATN06_03060 ENOG4105D5Q Arginine ornithine antiporter ATN06_03065 ENOG4107414 GntR family transcriptional regulator ATN06_03070 ENOG4105C5Y PTS System ATN06_03075 ENOG4105CG3 alpha amylase, catalytic region ATN06_03090 ENOG4105E1K spore germination protein ATN06_03100 ENOG4105CRN Aminoglycoside phosphotransferase ATN06_03105 ENOG4105BZG amino acid carrier protein ATN06_03115 ENOG4105CDA abc transporter atp-binding protein ATN06_03120 ENOG4105CT1 (ABC) transporter ATN06_03125 ENOG4105EAD ABC transporter ATN06_03130 ENOG4105DRP amino acid AbC transporter ATN06_03135 ENOG4108IQI permease ATN06_03150 ENOG4105D29 Helix-turn-helix type 11 domain protein ATN06_03155 ENOG4105NAE bifunctional deaminase-reductase domain protein ATN06_03160 ENOG4105BZU Histidine kinase ATN06_03175 ENOG4105CHH sulfate transporter ATN06_03180 ENOG41068KF Universal stress protein ATN06_03190 ENOG4105DEF Extracellular solute-binding protein, family 5 ATN06_03200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ATN06_03205 ENOG4108JQ7 (ABC) transporter ATN06_03215 ENOG4105CXY transporter ATN06_03220 ENOG41067TZ transcriptional regulator, MarR family ATN06_03225 ENOG4105C0R drug resistance transporter emrb qaca subfamily ATN06_03230 ENOG4105ETE Transcriptional regulator (LacI family ATN06_03235 ENOG4108RVA ribokinase ATN06_03245 ENOG4105C2J ABC transporter ATN06_03250 ENOG4105CNN ABC, transporter ATN06_03255 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ATN06_03260 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ATN06_03320 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ATN06_03325 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer ATN06_03330 ENOG41069ER domain protein ATN06_03335 ENOG4105VZ8 Transcriptional regulator ATN06_03340 ENOG4107D63 ATN06_03355 ENOG4105DUX Transporter ATN06_03375 ENOG4105C85 amino acid ATN06_03380 ENOG4105C7N Xanthine uracil vitamin C permease ATN06_03395 ENOG4105MA6 gCN5-related N-acetyltransferase ATN06_03420 ENOG4105BZ9 Cytochrome C oxidase, subunit I ATN06_03425 ENOG4105E2S oxidase) subunit II ATN06_03445 ENOG4106CAD Protein of unknown function (DUF3311) ATN06_03450 ENOG4105E1V na solute symporter ATN06_03465 ENOG4108NHD germination protein ATN06_03475 ENOG4105CE1 Ferrous iron transport protein b ATN06_03480 ENOG4105CE1 Ferrous iron transport protein b ATN06_03485 ENOG4105CE1 Ferrous iron transport protein b ATN06_03490 ENOG4105CVA phosphate ATN06_03495 ENOG4105C8U phosphate abc transporter ATN06_03500 ENOG4105E2Z phosphate ABC transporter (Permease ATN06_03625 ENOG41080XQ Signal transduction protein with cbs domains ATN06_03650 ENOG4105ETU transcriptional activator (TenA ATN06_03660 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ATN06_03670 ENOG4108VEU Thiamine monophosphate synthase ATN06_03690 ENOG4105D06 uba thif-type nad fad binding protein ATN06_03695 ENOG4105DWF phosphomethylpyrimidine kinase ATN06_03750 ENOG4108INS Transcriptional regulator ATN06_03775 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ATN06_03780 ENOG4105C7N Xanthine uracil vitamin C permease ATN06_03790 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ATN06_03825 ENOG4108B31 Spore germination protein ATN06_03845 ENOG4107Y03 Nitroreductase ATN06_03850 ENOG4105ED1 spovr family ATN06_03910 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase ATN06_03915 ENOG4105XTG Pfam:DUF156 ATN06_03920 ENOG4105VFE sira family ATN06_03925 ENOG4107TPS domain protein ATN06_03930 ENOG4105VFE sira family ATN06_03940 ENOG41085GJ domain protein ATN06_03950 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase ATN06_03955 ENOG41087NI Sulfite exporter TauE/SafE ATN06_03965 ENOG4108KGH TRANSCRIPTIONal ATN06_03990 ENOG4105EMD TRANSCRIPTIONal ATN06_03995 ENOG4105VCP PTS System ATN06_04000 ENOG4105VZJ PTS System ATN06_04025 ENOG41069ER domain protein ATN06_04045 ENOG4105XSJ toxin secretion phage lysis holin ATN06_04055 ENOG4105K4H Nlp p60 protein ATN06_04060 ENOG41069ER domain protein ATN06_04065 ENOG4107RBB ABC transporter, permease ATN06_04070 ENOG4105C19 ABC transporter ATN06_04100 ENOG4105WEF catalase ATN06_04135 ENOG4107T5V SNARE associated Golgi ATN06_04170 ENOG4105CUB amino acid ATN06_04175 ENOG4107RWR Sodium hydrogen exchanger ATN06_04185 ENOG4106KNT transcriptional regulator ATN06_04225 ENOG4108YXU transcriptional regulator AsnC family ATN06_04235 ENOG4105UBK short-chain dehydrogenase reductase ATN06_04245 ENOG4105KPY Small multidrug resistance protein ATN06_04275 ENOG4105NF4 modulator of drug activity ATN06_04280 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) ATN06_04285 ENOG4105E5W Transporter ATN06_04295 ENOG4107RKG DJ-1/PfpI family ATN06_04305 ENOG4105D5Q Arginine ornithine antiporter ATN06_04320 ENOG4105C26 Dehydrogenase ATN06_04330 ENOG4105BZ1 (ABC) transporter ATN06_04335 ENOG4105BZ1 (ABC) transporter ATN06_04345 ENOG4105DRP amino acid AbC transporter ATN06_04350 ENOG4105CDA abc transporter atp-binding protein ATN06_04365 ENOG410839P ATN06_04400 ENOG4107FQX Alpha-acetolactate decarboxylase ATN06_04420 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase ATN06_04425 ENOG4105D4P Coproporphyrinogen iii oxidase ATN06_04440 ENOG4107T5V SNARE associated Golgi ATN06_04460 ENOG4105CHH sulfate transporter ATN06_04495 ENOG4106AKK s-layer domain-containing protein ATN06_04505 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein ATN06_04510 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein ATN06_04525 ENOG4105CGU Enoyl-CoA hydratase ATN06_04545 ENOG4105DER m42 family ATN06_04565 ENOG4105C85 amino acid ATN06_04570 ENOG4108JPW Aminotransferase ATN06_04585 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) ATN06_04590 ENOG4105D5U fad dependent oxidoreductase ATN06_04620 ENOG410890F Dynamin family ATN06_04625 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ATN06_04650 ENOG4105D7A ATP-binding protein ATN06_04660 ENOG4105EYH Exonuclease ATN06_04670 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ATN06_04695 ENOG4107QI6 Cysteine desulfurase ATN06_04745 ENOG4105CDU Replicative dna helicase ATN06_04770 ENOG4105C0R drug resistance transporter emrb qaca subfamily ATN06_04815 ENOG4105F27 Major Facilitator ATN06_04820 ENOG4105WAB arsR family transcriptional regulator ATN06_04840 ENOG4105CID antiterminator ATN06_04845 ENOG4105C5Y PTS System ATN06_04850 ENOG4105CS2 ec 3.2.1.21 ATN06_04860 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase ATN06_04885 ENOG4105CMT Dihydroxyacetone kinase ATN06_04950 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ATN06_05015 ENOG4105WN5 stage II sporulation protein ATN06_05025 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ATN06_05035 ENOG4108MJI response regulator ATN06_05040 ENOG4105BZU Histidine kinase ATN06_05045 ENOG4105BZU Histidine kinase ATN06_05110 ENOG4107VRP DNA repair exonuclease ATN06_05115 ENOG4106D4I domain protein ATN06_05140 ENOG4108MUZ hydrolase ATN06_05150 ENOG41067QW Transcriptional regulator ATN06_05155 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator ATN06_05170 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ATN06_05190 ENOG4105EMN RNA polymerase sigma factor ATN06_05210 ENOG4105EYF MMPL domain protein ATN06_05225 ENOG4105EEM helicase ATN06_05235 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) ATN06_05265 ENOG4105K59 histidine triad (HIT) protein ATN06_05345 ENOG410905X membrane-flanked domain protein ATN06_05350 ENOG4105CKV Membrane ATN06_05390 ENOG410905X membrane-flanked domain protein ATN06_05395 ENOG4105CKV Membrane ATN06_05400 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation ATN06_05405 ENOG4105BZ4 penicillin-binding protein ATN06_05420 ENOG4105C1Q protoporphyrinogen oxidase ATN06_05430 ENOG4105D7V transposase ATN06_05450 ENOG4105NA0 Transcriptional regulator ATN06_05465 ENOG4105ECB domain protein ATN06_05500 ENOG4105D29 Helix-turn-helix type 11 domain protein ATN06_05510 ENOG4106AXD ATN06_05515 ENOG4108RQ5 Beta-lactamase domain-containing protein ATN06_05520 ENOG4105DF9 Lipoate-protein, ligase ATN06_05530 ENOG4105CEY Amp-dependent synthetase and ligase ATN06_05580 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) ATN06_05585 ENOG4107RN3 metallophosphoesterase ATN06_05590 ENOG4107TVP HD domain protein ATN06_05600 ENOG4105C57 major facilitator superfamily ATN06_05610 ENOG4108AEY RNA polymerase sigma factor ATN06_05615 ENOG41086D8 Transcriptional regulator ATN06_05630 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ATN06_05655 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 ATN06_05660 ENOG4105C8Q Methyl-accepting chemotaxis ATN06_05685 ENOG4107QP3 malate synthase g ATN06_05705 ENOG4105VEQ Cold shock protein ATN06_05720 ENOG4105XVF Competence transcription factor ATN06_05785 ENOG4105ERH Fumarylacetoacetate hydrolase ATN06_05795 ENOG4105C8Y Acetylornithine aminotransferase ATN06_05810 ENOG4105CAQ asparagine synthetase ATN06_05815 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ATN06_05820 ENOG4105CH6 catalase ATN06_05825 ENOG4105BZU Histidine kinase ATN06_05840 ENOG4107A6P ATN06_05865 ENOG4105QNR S1 RNA binding domain protein ATN06_05870 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) ATN06_05880 ENOG4107AYK membrAne ATN06_05885 ENOG41073B9 ATN06_05895 ENOG4108KP7 hydrolase ATN06_05935 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ATN06_05940 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ATN06_05955 ENOG4105C31 Tryptophanyl-tRNA synthetase ATN06_05970 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ATN06_05975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ATN06_05985 ENOG4108JQ7 (ABC) transporter ATN06_05990 ENOG4105UQX Mate efflux family protein ATN06_06015 ENOG4108ZCF integral membrane protein ATN06_06025 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ATN06_06035 ENOG4105DPN Oligoendopeptidase f ATN06_06050 ENOG4108Z18 K06886 hemoglobin ATN06_06055 ENOG4105MIX Adenylate cyclase ATN06_06060 ENOG4106EFP UPF0738 protein ATN06_06070 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ATN06_06075 ENOG4105EMS pseudouridine synthase ATN06_06095 ENOG4105K64 Glycosyl transferase, family 2 ATN06_06115 ENOG4107TVC Glycosyl transferase, family 2 ATN06_06135 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ATN06_06140 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase ATN06_06150 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase ATN06_06190 ENOG4105ENA helicase ATN06_06235 ENOG4105CK7 Sodium proline symporter ATN06_06245 ENOG4105CRQ synthase (Component I) ATN06_06250 ENOG4105DDQ anthranilate synthase ATN06_06270 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ATN06_06370 ENOG4105C7S Dehydrogenase ATN06_06380 ENOG4105VZ8 Transcriptional regulator ATN06_06455 ENOG4105DZ1 carboxypeptidase ATN06_06460 ENOG4105VFR signal peptidase ATN06_06475 ENOG4105DQ6 Transposase ATN06_06505 ENOG4105C26 Dehydrogenase ATN06_06515 ENOG4105F38 ABC transporter, permease ATN06_06520 ENOG4105D38 putrescine abc transporter ATN06_06525 ENOG4107RUE extracellular solute-binding protein family 1 ATN06_06535 ENOG4105EYF MMPL domain protein ATN06_06545 ENOG4108YBP pseudouridine synthase ATN06_06555 ENOG4105K4I Scp-like extracellular ATN06_06560 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ATN06_06565 ENOG4105CQB FAD linked oxidase domain protein ATN06_06580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_06585 ENOG4105BZU Histidine kinase ATN06_06590 ENOG4105JXH GntR family transcriptional regulator ATN06_06610 ENOG4106A3R peptidase ATN06_06620 ENOG4108QTI )-transporter ATN06_06625 ENOG4107TS3 membrane protein, TerC ATN06_06630 ENOG4105CZN Potassium uptake protein ATN06_06635 ENOG410681C small acid-soluble spore protein ATN06_06640 ENOG4108Z7G MaoC domain protein dehydratase ATN06_06660 ENOG4105CHR reductase ATN06_06690 ENOG4105C4Y ABC transporter ATN06_06695 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ATN06_06700 ENOG4107RCV ABC transporter, permease ATN06_06720 ENOG4105E98 transcriptional regulator DeoR family ATN06_06735 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) ATN06_06745 ENOG4105PXI polysaccharide deacetylase ATN06_06755 ENOG4105BZU Histidine kinase ATN06_06760 ENOG41090MY MarR family Transcriptional regulator ATN06_06770 ENOG4106DF1 ATN06_06780 ENOG4105BZU Histidine kinase ATN06_06790 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase ATN06_06795 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ATN06_06845 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) ATN06_06860 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ATN06_06865 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family ATN06_06870 ENOG4105CZV ABC transporter ATN06_06880 ENOG4105CJ1 ABC, transporter ATN06_06920 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ATN06_06925 ENOG4105EA8 2-Nitropropane dioxygenase ATN06_06930 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD ATN06_06940 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein ATN06_06965 ENOG4105NQC Flavodoxin ATN06_07000 ENOG4107QMU Mate efflux family protein ATN06_07035 ENOG4105CZN Potassium uptake protein ATN06_07040 ENOG41063Y9 ATN06_07045 ENOG4105KBJ sporulation protein ytfj ATN06_07075 ENOG4105CM2 brancheD-chain amino acid aminotransferase ATN06_07080 ENOG4105C7K acetolactate synthase ATN06_07085 ENOG4108ZP8 Acetolactate synthase small subunit ATN06_07160 ENOG4107RVV histidinol phosphate phosphatase, hisj family ATN06_07170 ENOG4105C5I Dehydrogenase ATN06_07175 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase ATN06_07180 ENOG4105E0M Sulfatase ATN06_07190 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ATN06_07210 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) ATN06_07215 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ATN06_07225 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ATN06_07230 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein ATN06_07235 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein ATN06_07245 ENOG4105C8J )-transporter ATN06_07265 ENOG4105DFD Na H antiporter ATN06_07285 ENOG4105ENE Histidine kinase ATN06_07290 ENOG4105WH1 Two component transcriptional regulator luxr family ATN06_07310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ATN06_07360 ENOG4105CJ3 phosphate transporter ATN06_07365 ENOG4107GRR phosphate transport regulator ATN06_07370 ENOG4105BZ4 penicillin-binding protein ATN06_07385 ENOG4105BZU Histidine kinase ATN06_07390 ENOG4105I3N Conserved Protein ATN06_07405 ENOG4105BZU Histidine kinase ATN06_07435 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ATN06_07440 ENOG4105DZ1 carboxypeptidase ATN06_07445 ENOG4108JIC nucleoside recognition domain protein ATN06_07455 ENOG4105FE9 pseudouridine synthase ATN06_07465 ENOG4107TWT Cytochrome c biogenesis protein ATN06_07470 ENOG4105CRE cytochrome C ATN06_07475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_07480 ENOG4105BZU Histidine kinase ATN06_07485 ENOG4108WBT adenosyltransferase ATN06_07490 ENOG41063SB peptidase ATN06_07500 ENOG4108SAX Membrane ATN06_07515 ENOG4105C9U ATP-dependent DNA helicase RecQ ATN06_07520 ENOG4105I7S Abortive infection protein ATN06_07530 ENOG4107RGJ metallophosphoesterase ATN06_07535 ENOG4107X2D transcriptional regulator, merr family ATN06_07540 ENOG4108S6Z Negative regulator of genetic competence ATN06_07565 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase ATN06_07570 ENOG4107RB3 L-asparaginase ATN06_07605 ENOG4105S2F ATN06_07610 ENOG41065D1 ATN06_07615 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ATN06_07640 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) ATN06_07655 ENOG4105XXQ heptaprenyl diphosphate synthase component I ATN06_07665 ENOG4105EAH synthase ATN06_07690 ENOG41068YB TPR repeat-containing protein ATN06_07705 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) ATN06_07710 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ATN06_07745 ENOG4108JYZ YitT family ATN06_07750 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase ATN06_07765 ENOG4105FJR Lmbe family ATN06_07770 ENOG4105CPK Glycosyl transferase (Group 1 ATN06_07810 ENOG4105DVT helicase ATN06_07815 ENOG4105YAC ATN06_07835 ENOG4105CSM endonuclease III ATN06_07845 ENOG4105BZ4 penicillin-binding protein ATN06_07895 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ATN06_07905 ENOG4105DVT helicase ATN06_07910 ENOG4105CTD carboxy-peptidase ATN06_07920 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ATN06_07925 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) ATN06_07930 ENOG4105C2W permease ATN06_07935 ENOG4105DHF Membrane ATN06_07940 ENOG410890F Dynamin family ATN06_07950 ENOG4108W0I acetyltransferase ATN06_07960 ENOG4105KHC sulfurtransferase ATN06_07975 ENOG4106032 Glutathionylspermidine synthase ATN06_08005 ENOG4105DQ6 Transposase ATN06_08045 ENOG4105CPK Glycosyl transferase (Group 1 ATN06_08060 ENOG4108SZE gCN5-related N-acetyltransferase ATN06_08080 ENOG41081VK Ribonuclease ATN06_08145 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ATN06_08155 ENOG4107RWR Sodium hydrogen exchanger ATN06_08160 ENOG4105CN5 Metallo-Beta-Lactamase ATN06_08165 ENOG4108Z5V transcriptional regulator, merr family ATN06_08175 ENOG4105H67 Protein of unknown function (DUF421) ATN06_08180 ENOG41080C8 DUF218 domain ATN06_08240 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ATN06_08250 ENOG4107R0U MotA TolQ exbB proton channel ATN06_08255 ENOG4105ER2 Ompa motb domain protein ATN06_08260 ENOG4107YTP response regulator receiver protein ATN06_08265 ENOG4105CBS Chea signal transduction histidine kinase ATN06_08270 ENOG4105DD5 Flagellar motor switch protein ATN06_08285 ENOG4105BZU Histidine kinase ATN06_08305 ENOG4105E1Q flagellar hook-associated protein ATN06_08310 ENOG4105DTJ flagellar hook-associated protein ATN06_08330 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ATN06_08335 ENOG4108ZC9 flagellar basal-body rod protein flgc ATN06_08340 ENOG41075Z6 flagellar hook-basal body complex protein fliE ATN06_08345 ENOG4107U2N Flagellar M-ring protein ATN06_08350 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ATN06_08380 ENOG4105BZE flagellar hook protein, FlgE ATN06_08395 ENOG4107R88 Chemotaxis protein (CheV) ATN06_08405 ENOG4105I03 Flagellin ATN06_08410 ENOG4105I03 Flagellin ATN06_08415 ENOG4105E4C Lytic transglycosylase catalytic ATN06_08425 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ATN06_08430 ENOG4105DD5 Flagellar motor switch protein ATN06_08440 ENOG4105CN7 Flagellar biosynthetic protein FliP ATN06_08445 ENOG4105VS8 Flagellar biosynthetic protein fliq ATN06_08455 ENOG4105D00 flagellar biosynthetic protein flhB ATN06_08460 ENOG4105D7B Flagellar biosynthesis protein flha ATN06_08465 ENOG4105FZW flagellar biosynthesis regulator FlhF ATN06_08470 ENOG4105KTQ flagellar basal-body rod protein ATN06_08475 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ATN06_08520 ENOG4105KAC Antibiotic biosynthesis monooxygenase ATN06_08545 ENOG4105DUM transcriptional regulator, lysR family ATN06_08550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ATN06_08555 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ATN06_08560 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component ATN06_08565 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) ATN06_08600 ENOG4105CVJ phosphoglycerate mutase ATN06_08615 ENOG4105K56 Transcriptional regulator ATN06_08625 ENOG4105CAQ asparagine synthetase ATN06_08645 ENOG4105PGM cation diffusion facilitator family transporter ATN06_08655 ENOG4105DRR Transcriptional regulator, GntR family ATN06_08660 ENOG4108UZ3 Transporter ATN06_08670 ENOG4105DFD Na H antiporter ATN06_08675 ENOG4105C9Q fumarate hydratase class II ATN06_08700 ENOG4107QJQ Mate efflux family protein ATN06_08705 ENOG4105EC3 peptidase S51, dipeptidase E ATN06_08725 ENOG4107QIV Cytochrome c biogenesis protein ATN06_08750 ENOG4106BRA Membrane ATN06_08785 ENOG4105CJ1 ABC, transporter ATN06_08805 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ATN06_08815 ENOG4108IJ0 Aspartate ammonia-lyase ATN06_08820 ENOG4105C6K Malic enzyme ATN06_08835 ENOG4105C0D helicase ATN06_08890 ENOG4105FVX ATN06_08930 ENOG4105CSR polyphosphate kinase 2 ATN06_08935 ENOG4105DXI Major Facilitator superfamily ATN06_08950 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ATN06_08960 ENOG4105EU0 Major facilitator Superfamily ATN06_08965 ENOG4105C6T cysteine synthase ATN06_08985 ENOG4105C8J )-transporter ATN06_08995 ENOG4105X5K response regulator receiver protein ATN06_09000 ENOG4105H67 Protein of unknown function (DUF421) ATN06_09015 ENOG4105DQ6 Transposase ATN06_09040 ENOG4105C19 ABC transporter ATN06_09045 ENOG4107Y80 Major Facilitator superfamily ATN06_09070 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ATN06_09075 ENOG4105CM2 brancheD-chain amino acid aminotransferase ATN06_09080 ENOG4105C7K acetolactate synthase ATN06_09090 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ATN06_09100 ENOG4105C7B Threonine dehydratase ATN06_09125 ENOG4105C6X Major Facilitator ATN06_09135 ENOG4105E5G Alpha beta hydrolase fold ATN06_09140 ENOG4107X42 5-methylthioadenosine S-adenosylhomocysteine nucleosidase ATN06_09145 ENOG4105DY9 regulatoR ATN06_09150 ENOG4105CYC Transferase ATN06_09170 ENOG4105F6J Alpha beta hydrolase fold ATN06_09200 ENOG41068WN ATN06_09205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ATN06_09220 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) ATN06_09235 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ATN06_09245 ENOG4105C0X amino acid ATN06_09305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_09310 ENOG4105BZU Histidine kinase ATN06_09330 ENOG4107RHR regulatoR ATN06_09340 ENOG4105D9N nucleoside ATN06_09345 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) ATN06_09375 ENOG410811B TRANSCRIPTIONal ATN06_09390 ENOG4107RAQ aminopeptidase ATN06_09395 ENOG4107R16 Multicopper oxidase ATN06_09445 ENOG4105DQ6 Transposase ATN06_09460 ENOG4108T5E Copper resistance protein ATN06_09465 ENOG4105KTB nuclear export factor GLE1 ATN06_09475 ENOG4107RT3 EamA-like transporter family ATN06_09480 ENOG4105GZI Transcriptional regulator ATN06_09485 ENOG4108Z40 Transcriptional regulator ATN06_09490 ENOG4107ZXU DSBA oxidoreductase ATN06_09495 ENOG4108TVJ Nitroreductase ATN06_09505 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ATN06_09510 ENOG4106F5Q Membrane ATN06_09515 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ATN06_09525 ENOG4105CKI cobalamin synthesis protein ATN06_09545 ENOG4108Z7G MaoC domain protein dehydratase ATN06_09550 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ATN06_09560 ENOG4105C0Z ABC transporter ATN06_09565 ENOG4108IV0 ABC, transporter ATN06_09570 ENOG4105C32 Amino acid ABC transporter (Permease) ATN06_09580 ENOG4105SKE transcriptional Regulator LysR family ATN06_09610 ENOG4105C4M (Ubiquinol oxidase) subunit I ATN06_09615 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ATN06_09620 ENOG4108JJ9 ABC, transporter ATN06_09625 ENOG4108JJ8 (ABC) transporter ATN06_09635 ENOG4105K64 Glycosyl transferase, family 2 ATN06_09645 ENOG4108UT6 Transferase hexapeptide repeat containing protein ATN06_09690 ENOG4105BZ1 (ABC) transporter ATN06_09700 ENOG4105D7V transposase ATN06_09705 ENOG4105EFI regulatoR ATN06_09710 ENOG4105BZU Histidine kinase ATN06_09725 ENOG4108VQJ O-methyltransferase ATN06_09730 ENOG41075D4 Aminoglycoside 6-adenylyltransferase ATN06_09735 ENOG4108ZJ4 polysaccharide deacetylase ATN06_09750 ENOG4105D6E homoserine dehydrogenase ATN06_09775 ENOG4108KGH TRANSCRIPTIONal ATN06_09785 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ATN06_09790 ENOG4105BZU Histidine kinase ATN06_09795 ENOG4107VMI polysaccharide deacetylase ATN06_09805 ENOG4105KT7 mgtC SapB transporter ATN06_09810 ENOG4105VRR gCN5-related N-acetyltransferase ATN06_09820 ENOG4105DUU IucA IucC family protein ATN06_09825 ENOG4105CEY Amp-dependent synthetase and ligase ATN06_09840 ENOG4108WBH protein TIM barrel ATN06_09845 ENOG4105YWU small acid-soluble spore protein ATN06_09855 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ATN06_09860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ATN06_09910 ENOG4105KRN Transcriptional regulator, abrb family ATN06_09920 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase ATN06_09925 ENOG4105YVS arsR family transcriptional regulator ATN06_09930 ENOG4105CPC Aldo Keto reductase ATN06_09935 ENOG4107XZQ multidrug resistance protein ATN06_09940 ENOG4105KAF membrAne ATN06_09965 ENOG4105C8Q Methyl-accepting chemotaxis ATN06_09980 ENOG4108K88 Membrane ATN06_09985 ENOG4108WPJ Ferritin-like domain ATN06_10000 ENOG4105DEN Luciferase family ATN06_10015 ENOG4105VMI -acetyltransferase ATN06_10020 ENOG4107QM2 Aldo Keto reductase ATN06_10025 ENOG4105CKI cobalamin synthesis protein ATN06_10035 ENOG4105DSE periplasmic solute binding protein ATN06_10045 ENOG4105K4T epimerase ATN06_10055 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ATN06_10100 ENOG4107T5V SNARE associated Golgi ATN06_10115 ENOG4108PJD permease ATN06_10125 ENOG4108S4H thioesterase Superfamily protein ATN06_10130 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ATN06_10150 ENOG4105SXS Protein of unknown function (DUF456) ATN06_10155 ENOG4105C37 (CBS) domain ATN06_10175 ENOG4108Z7R Chaperone CsaA ATN06_10195 ENOG4108ZRV stage ii sporulation protein p ATN06_10205 ENOG4108VXD carboxy-peptidase ATN06_10210 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ATN06_10215 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ATN06_10235 ENOG4105EFA 4-hydroxyphenylacetate ATN06_10245 ENOG4105U1N riboflavin ATN06_10260 ENOG4105KME endoribonuclease L-psp ATN06_10300 ENOG4108X4Q Hydrolase ATN06_10310 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ATN06_10315 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) ATN06_10330 ENOG4108JYZ YitT family ATN06_10335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ATN06_10360 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ATN06_10430 ENOG4105KBJ sporulation protein ytfj ATN06_10455 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ATN06_10475 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ATN06_10485 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ATN06_10490 ENOG4105EMN RNA polymerase sigma factor ATN06_10510 ENOG4105CNW domain protein ATN06_10520 ENOG4108V06 Glutathione peroxidase ATN06_10535 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ATN06_10585 ENOG4105MCT stage V sporulation protein S ATN06_10600 ENOG4105C5H ABC transporter ATN06_10615 ENOG4108UUM single-stranded DNA-binding protein ATN06_10635 ENOG4107YX5 Pfam:DUF548 ATN06_10640 ENOG4105C75 arginyL-tRNA synthetase ATN06_10670 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) ATN06_10675 ENOG4105C5S asparaginyl-tRNA synthetase ATN06_10695 ENOG4105EC2 ftsk spoIIIe ATN06_10735 ENOG4105C8J )-transporter ATN06_10755 ENOG4107XGZ Hydrolase ATN06_10760 ENOG4105CY2 Citrate transporter ATN06_10765 ENOG4105C0A alcohol dehydrogenase ATN06_10780 ENOG4105KD7 acetyltransferase ATN06_10785 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ATN06_10810 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 ATN06_10830 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) ATN06_10850 ENOG4107RVG penicillin-binding protein ATN06_10860 ENOG4105E9Q Acyl-transferase ATN06_10865 ENOG4108UT2 hemolysin iii ATN06_10875 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ATN06_10885 ENOG4108RCR degv family ATN06_10890 ENOG4105E8R UPF0173 metal-dependent hydrolase ATN06_10895 ENOG4108KF3 Electron transport protein SCO1 SenC ATN06_10900 ENOG4107Y70 Heat shock protein ATN06_10905 ENOG4105CAQ asparagine synthetase ATN06_10920 ENOG4108MES Periplasmic binding protein ATN06_10925 ENOG4105F0I Aminotransferase ATN06_10955 ENOG4107Y70 Heat shock protein ATN06_10960 ENOG4105D8X mechanosensitive ion channel ATN06_10965 ENOG4105BZU Histidine kinase ATN06_10970 ENOG4105WH1 Two component transcriptional regulator luxr family ATN06_10975 ENOG4106KNT transcriptional regulator ATN06_11005 ENOG4105CMG Carbohydrate kinase ATN06_11010 ENOG4105C6Z Gluconate ATN06_11045 ENOG4108IJ8 ABC transporter ATN06_11050 ENOG4105E90 ABC transporter ATN06_11085 ENOG4105C37 (CBS) domain ATN06_11110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ATN06_11125 ENOG4107S4Y M20 DapE family protein YgeY ATN06_11130 ENOG4108TSC N-acetyltransferase ATN06_11135 ENOG4108JUB Transcriptional regulator ATN06_11140 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ATN06_11180 ENOG4108N23 SpoOM-related protein ATN06_11185 ENOG410841Q phosphoesterase PA-phosphatase related protein ATN06_11195 ENOG4105SZ6 Thioredoxin ATN06_11230 ENOG4108AEY RNA polymerase sigma factor ATN06_11275 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) ATN06_11330 ENOG4105BZ4 penicillin-binding protein ATN06_11340 ENOG4105CZM Major Facilitator ATN06_11355 ENOG4105DXD 2-methylcitrate dehydratase ATN06_11360 ENOG4105CR4 methylisocitrate lyase ATN06_11365 ENOG4105C1G acyl-Coa dehydrogenase ATN06_11370 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ATN06_11380 ENOG4105N14 lysine exporter protein LysE YggA ATN06_11385 ENOG4105E39 Enoyl-CoA hydratase ATN06_11400 ENOG4107RFY SbcCD D subunit ATN06_11430 ENOG4105FCD Major Facilitator ATN06_11435 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ATN06_11440 ENOG4105E4F Isochorismate synthase ATN06_11445 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ATN06_11450 ENOG4105WQI isochorismatase ATN06_11455 ENOG4105CEY Amp-dependent synthetase and ligase ATN06_11460 ENOG4105WQT MbtH domain protein ATN06_11465 ENOG4105C0R drug resistance transporter emrb qaca subfamily ATN06_11480 ENOG4105K70 DNA-binding protein ATN06_11500 ENOG4105BZG amino acid carrier protein ATN06_11530 ENOG4105FE9 pseudouridine synthase ATN06_11535 ENOG4105C22 threonyL-tRNA synthetase ATN06_11545 ENOG4105C19 ABC transporter ATN06_11555 ENOG4107SKW Inherit from COG: Alpha beta hydrolase ATN06_11610 ENOG41081I9 integral membrane protein ATN06_11635 ENOG4107MII Sugar-specific transcriptional regulator TrmB ATN06_11640 ENOG4105D7V transposase ATN06_11655 ENOG4105EYF MMPL domain protein ATN06_11680 ENOG4105WCN acetyltransferase ATN06_11705 ENOG4105C1Q protoporphyrinogen oxidase ATN06_11715 ENOG41068WN ATN06_11745 ENOG4108KP7 hydrolase ATN06_11755 ENOG4107V2S Transcriptional regulator ATN06_11760 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ATN06_11775 ENOG4105DND Transcriptional regulator ATN06_11780 ENOG4108RPX mosc domain containing protein ATN06_11795 ENOG4105BZ1 (ABC) transporter ATN06_11800 ENOG4105BZ1 (ABC) transporter ATN06_11825 ENOG4108JCI Transcriptional regulator ATN06_11860 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B ATN06_11865 ENOG4108KPJ rna polymerase sigma factor ATN06_11890 ENOG4105F32 YngK protein ATN06_11910 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) ATN06_11915 ENOG4105RD7 BadF BadG BcrA BcrD ATN06_11950 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ATN06_11965 ENOG4105C1J atp-dependent rna helicase ATN06_11990 ENOG4108RZE Tetr family transcriptional regulator ATN06_12010 ENOG41088CC tellurite resistance protein tehB ATN06_12020 ENOG4108I0C methyltransferase ATN06_12025 ENOG4107RA9 decarboxylase ATN06_12030 ENOG41090HR transcriptional regulator ATN06_12055 ENOG4105CIN aminoacyl-histidine dipeptidase ATN06_12065 ENOG4105EQK -acetyltransferase ATN06_12090 ENOG4105DVH amino acid ATN06_12105 ENOG4105EJQ L-serine dehydratase ATN06_12110 ENOG4105C44 Serine transporter ATN06_12130 ENOG4105F6S Spore photoproduct lyase ATN06_12135 ENOG4105CVK Glutamate decarboxylase ATN06_12170 ENOG4107RVG penicillin-binding protein ATN06_12175 ENOG4105EMN RNA polymerase sigma factor ATN06_12185 ENOG4105CJN penicillin-binding protein ATN06_12190 ENOG4107RF6 penicillin-binding protein ATN06_12200 ENOG4105EXC Acyl-transferase ATN06_12270 ENOG4108XG2 Histidine kinase ATN06_12275 ENOG4105WH1 Two component transcriptional regulator luxr family ATN06_12280 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin ATN06_12325 ENOG4108VXD carboxy-peptidase ATN06_12335 ENOG4105D7V transposase ATN06_12345 ENOG4105BZU Histidine kinase ATN06_12385 ENOG4105CJ1 ABC, transporter ATN06_12395 ENOG4107Z3H Transcriptional regulator, TetR family ATN06_12410 ENOG4105C1G acyl-Coa dehydrogenase ATN06_12415 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ATN06_12420 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit ATN06_12425 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase ATN06_12430 ENOG4105E39 Enoyl-CoA hydratase ATN06_12435 ENOG4107QX3 carboxylase ATN06_12440 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ATN06_12460 ENOG4105DBI uridine monophosphokinase ATN06_12490 ENOG4105T9C HD domain ATN06_12505 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ATN06_12510 ENOG4108RYK Nad-dependent epimerase dehydratase ATN06_12540 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ATN06_12555 ENOG4105FQP Beta-lactamase ATN06_12565 ENOG4107Y80 Major Facilitator superfamily ATN06_12585 ENOG41089UC methyltransferase, type 11 ATN06_12625 ENOG4105EFA 4-hydroxyphenylacetate ATN06_12645 ENOG410900G Protein of unknown function (DUF421) ATN06_12655 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ATN06_12735 ENOG4105D6E homoserine dehydrogenase ATN06_12750 ENOG4105ETU transcriptional activator (TenA ATN06_12990 ENOG410667J hydrolase ATN06_12995 ENOG4105BZU Histidine kinase ATN06_13000 ENOG4107RF6 penicillin-binding protein ATN06_13030 ENOG4108HGU Histidine kinase ATN06_13040 ENOG4105RHY Pfam:UPF0157 ATN06_13050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_13055 ENOG4105GR3 Histidine kinase ATN06_13060 ENOG4105CB2 alcohol dehydrogenase ATN06_13065 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase ATN06_13070 ENOG4105CJN penicillin-binding protein ATN06_13125 ENOG4108V4B ThiJ pfpI ATN06_13135 ENOG4107Y80 Major Facilitator superfamily ATN06_13170 ENOG4107Y9U Membrane ATN06_13190 ENOG4105EGD dinuclear metal center protein, YbgI family ATN06_13215 ENOG4105FCD Major Facilitator ATN06_13230 ENOG4105E09 nadh pyrophosphatase ATN06_13235 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ATN06_13240 ENOG4108Z4K mutator MutT protein ATN06_13260 ENOG4105KME endoribonuclease L-psp ATN06_13265 ENOG4108XI2 Domain of unknown function (DUF1963) ATN06_13290 ENOG4108NRW Phospholipase, patatin family ATN06_13295 ENOG4105KWG Pfam:DUF1696 ATN06_13330 ENOG4105PKS Excinuclease abc c subunit domain protein ATN06_13370 ENOG4107VFR oxidoreductase ATN06_13400 ENOG4105U0R haloacid dehalogenase-like hydrolase ATN06_13405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_13410 ENOG4105BZU Histidine kinase ATN06_13445 ENOG4107WD8 ABC transporter, permease ATN06_13460 ENOG4108IUM Glycogen debranching enzyme ATN06_13475 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ATN06_13485 ENOG4105FDR Membrane ATN06_13495 ENOG4105CIS alcohol dehydrogenase ATN06_13545 ENOG4105MSI germination protein ypeb ATN06_13585 ENOG4107Z3H Transcriptional regulator, TetR family ATN06_13610 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family ATN06_13630 ENOG4105E98 transcriptional regulator DeoR family ATN06_13650 ENOG41062ES Transcriptional regulator ATN06_13670 ENOG4107QKR Dehydrogenase ATN06_13680 ENOG4107RUY (E1 component), alpha subunit ATN06_13690 ENOG4105E1F short-chain dehydrogenase reductase ATN06_13695 ENOG4105RHY Pfam:UPF0157 ATN06_13700 ENOG4105DBI uridine monophosphokinase ATN06_13735 ENOG4107SQ8 Glycine betaine ATN06_13740 ENOG4108IJ7 Glycine betaine ATN06_13770 ENOG41082BV acetyltransferase ATN06_13775 ENOG4108M1A Chitin-binding protein ATN06_13780 ENOG41087PP glycosyltransferase MGT family ATN06_13790 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ATN06_13800 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ATN06_13805 ENOG4105MSB protein, conserved in bacteria ATN06_13815 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 ATN06_13865 ENOG4105EEM helicase ATN06_13885 ENOG4105C9U ATP-dependent DNA helicase RecQ ATN06_13940 ENOG4108M1A Chitin-binding protein ATN06_13965 ENOG4105BZG amino acid carrier protein ATN06_13970 ENOG4105C26 Dehydrogenase ATN06_13975 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ATN06_13980 ENOG4105CTU Proline racemase ATN06_13985 ENOG4105CTU Proline racemase ATN06_13990 ENOG41080HI glycine oxidase ATN06_14000 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein ATN06_14030 ENOG4107T5V SNARE associated Golgi ATN06_14045 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD ATN06_14075 ENOG4105DTQ mandelate racemase muconate lactonizing ATN06_14090 ENOG4105CPC Aldo Keto reductase ATN06_14130 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) ATN06_14135 ENOG4105BZU Histidine kinase ATN06_14140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_14165 ENOG4105DPN Oligoendopeptidase f ATN06_14170 ENOG4105DVH amino acid ATN06_14180 ENOG4105EPR degv family ATN06_14250 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) ATN06_14255 ENOG4106K7D Major facilitator family transporter ATN06_14280 ENOG4107BMA Transglycosylase associated protein ATN06_14295 ENOG41089UC methyltransferase, type 11 ATN06_14335 ENOG4105CHM Aminotransferase ATN06_14350 ENOG4108ZMI UPF0477 protein ATN06_14365 ENOG4105DVE abc transporter atp-binding protein ATN06_14425 ENOG4105C02 permease ATN06_14445 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ATN06_14450 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein ATN06_14475 ENOG4105E09 nadh pyrophosphatase ATN06_14495 ENOG4108AQF aminoglycoside N(3)-acetyltransferase ATN06_14545 ENOG4107VMI polysaccharide deacetylase ATN06_14555 ENOG4108ZCF integral membrane protein ATN06_14565 ENOG4105C5H ABC transporter ATN06_14570 ENOG4105EYF MMPL domain protein ATN06_14575 ENOG41082JN Transcriptional regulator ATN06_14605 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase ATN06_14640 ENOG41069ER domain protein ATN06_14660 ENOG4105D4B ABC, transporter ATN06_14670 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane ATN06_14680 ENOG4105DKT Transcriptional regulator ATN06_14685 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) ATN06_14695 ENOG41061GT Aldolase ATN06_14725 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) ATN06_14755 ENOG4105II7 pyrroline-5-carboxylate reductase ATN06_14765 ENOG4107258 Transcriptional regulator ATN06_14775 ENOG4105E0Y RtcB Protein ATN06_14780 ENOG4105ECK Fatty Acid Desaturase ATN06_14790 ENOG4105G6Z alkaline phosphatase ATN06_14800 ENOG4105VMP Transcriptional regulator ATN06_14815 ENOG41090T1 Membrane ATN06_14825 ENOG4108WCX response regulator ATN06_14840 ENOG41068WN ATN06_14865 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ATN06_14885 ENOG4105C8Y Acetylornithine aminotransferase ATN06_14930 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ATN06_14935 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ATN06_14945 ENOG4105CHH sulfate transporter ATN06_14965 ENOG4108TVJ Nitroreductase ATN06_14970 ENOG4105FS7 Transcriptional regulator ATN06_14990 ENOG4105ERH Fumarylacetoacetate hydrolase ATN06_15010 ENOG4105CEY Amp-dependent synthetase and ligase ATN06_15015 ENOG4105CHU acetyl-coa acetyltransferase ATN06_15020 ENOG4105E39 Enoyl-CoA hydratase ATN06_15025 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ATN06_15030 ENOG4105CS2 ec 3.2.1.21 ATN06_15035 ENOG4105VCP PTS System ATN06_15040 ENOG4108QVC Component IIC ATN06_15055 ENOG4105VZJ PTS System ATN06_15065 ENOG4105G9B Transcriptional regulator ATN06_15070 ENOG4105D2S major facilitator superfamily ATN06_15075 ENOG4105EFZ amidohydrolase ATN06_15085 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ATN06_15110 ENOG4108DMH HTH_ARAC ATN06_15115 ENOG4108XET gCN5-related N-acetyltransferase ATN06_15130 ENOG4108PCN EamA-like transporter family ATN06_15140 ENOG4107XJU UPF0178 protein ATN06_15190 ENOG410635A Membrane ATN06_15200 ENOG4108IQI permease ATN06_15215 ENOG4105F1N DNA alkylation repair ATN06_15225 ENOG4107ZY0 Phenazine biosynthesis-like protein ATN06_15260 ENOG4107RF6 penicillin-binding protein ATN06_15270 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ATN06_15300 ENOG4105P4J Allophanate hydrolase, subunit 1 ATN06_15305 ENOG4107258 Transcriptional regulator ATN06_15325 ENOG4106N3A copper homeostasis protein cutc ATN06_15330 ENOG4108ZRV stage ii sporulation protein p ATN06_15335 ENOG4105FDT acyl-CoA dehydrogenase ATN06_15350 ENOG4105DWD nucleoside recognition domain protein ATN06_15385 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) ATN06_15410 ENOG4105E2A Dehydrogenase ATN06_15415 ENOG4105BZU Histidine kinase ATN06_15440 ENOG41075H3 AraC family transcriptional regulator ATN06_15450 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ATN06_15455 ENOG4105CUB amino acid ATN06_15460 ENOG4105II7 pyrroline-5-carboxylate reductase ATN06_15465 ENOG4108NHD germination protein ATN06_15470 ENOG4108Q8B Spore germination protein ATN06_15520 ENOG4105CGH 5'-nucleotidase ATN06_15530 ENOG4105CHJ isochorismatase hydrolase ATN06_15625 ENOG4105E1K spore germination protein ATN06_15645 ENOG4105CVP deoxyribo-dipyrimidine photolyase ATN06_15660 ENOG4108TWJ NADH dehydrogenase subunit 5 ATN06_15665 ENOG4105GPN Uncharacterized conserved protein (DUF2294) ATN06_15675 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ATN06_15700 ENOG4108JGH Tetr family transcriptional regulator ATN06_15705 ENOG4105EQ0 Major Facilitator superfamily ATN06_15790 ENOG4105D6J arsenicaL-resistance protein ATN06_15795 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase ATN06_15800 ENOG41085FC arsR family transcriptional regulator ATN06_15815 ENOG4105F7F Chaperone ATN06_15820 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ATN06_15825 ENOG4108YXU transcriptional regulator AsnC family ATN06_15870 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ATN06_15875 ENOG4105C0R drug resistance transporter emrb qaca subfamily ATN06_15895 ENOG4105M4P Tetr family transcriptional regulator ATN06_15915 ENOG4108NIW Leucine export protein LeuE ATN06_15950 ENOG4105K6H D-cysteine desulfhydrase ATN06_15975 ENOG4105VZ8 Transcriptional regulator ATN06_15995 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase ATN06_16035 ENOG4105W1Y Transcriptional regulator ATN06_16040 ENOG4105JQZ Methyltransferase ATN06_16060 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) ATN06_16080 ENOG4105BZU Histidine kinase ATN06_16090 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) ATN06_16095 ENOG4105DJB Major Facilitator Superfamily ATN06_16100 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) ATN06_16105 ENOG4107QR9 Iron-sulfur cluster binding protein ATN06_16115 ENOG4106P55 Transcriptional regulator ATN06_16135 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ATN06_16155 ENOG4108JQ1 Dehydrogenase ATN06_16205 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase ATN06_16255 ENOG4108ISG Major Facilitator ATN06_16270 ENOG4107MII Sugar-specific transcriptional regulator TrmB ATN06_16275 ENOG4105CZM Major Facilitator ATN06_16295 ENOG4105DA5 (ABC) transporter ATN06_16300 ENOG41069JR ATN06_16320 ENOG4108QY0 Membrane ATN06_16335 ENOG4105FQ6 thiopurine methyltransferase ATN06_16345 ENOG4105C26 Dehydrogenase ATN06_16370 ENOG4105CRW Short chain fatty acid transporter ATN06_16380 ENOG4105DYS nad(p)h dehydrogenase (quinone) ATN06_16410 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) ATN06_16435 ENOG4108K8S endonuclease I ATN06_16445 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ATN06_16450 ENOG4105D7V transposase ATN06_16480 ENOG4107TXC Transcriptional regulator ATN06_16510 ENOG4108Z66 YbaK ebsC protein ATN06_16530 ENOG4105KVH Transcriptional regulator ATN06_16535 ENOG4108RCM Nitroreductase ATN06_16555 ENOG4108PSK reductase ATN06_16655 ENOG4107WD8 ABC transporter, permease ATN06_16665 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase ATN06_16670 ENOG4105DKQ ROK family ATN06_16675 ENOG4108UW5 maltose o-acetyltransferase ATN06_16685 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ATN06_16690 ENOG4105C31 Tryptophanyl-tRNA synthetase ATN06_16730 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) ATN06_16740 ENOG4105EV4 Multidrug resistance protein mdtH ATN06_16765 ENOG4105C37 (CBS) domain ATN06_16780 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase ATN06_16785 ENOG4105FAW cDP-glucose 4,6-dehydratase ATN06_16810 ENOG4105DDN Pentapeptide repeat-containing protein ATN06_16815 ENOG4105XDF Protein of unknown function (DUF1272) ATN06_16820 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) ATN06_16825 ENOG4105CMG Carbohydrate kinase ATN06_16830 ENOG4105C6Z Gluconate ATN06_16850 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ATN06_16860 ENOG4105CIS alcohol dehydrogenase ATN06_16865 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ATN06_16890 ENOG4105EWI Short-chain dehydrogenase reductase Sdr ATN06_16905 ENOG4105C8Q Methyl-accepting chemotaxis ATN06_16910 ENOG4108UX3 '-nucleotidase ATN06_16915 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ATN06_16920 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ATN06_16925 ENOG4105KVH Transcriptional regulator ATN06_16940 ENOG4105CV8 reductase ATN06_16945 ENOG4105F27 Major Facilitator ATN06_16955 ENOG41090KN UPF0303 protein ATN06_16960 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) ATN06_16965 ENOG4105C44 Serine transporter ATN06_17000 ENOG4105KVH Transcriptional regulator ATN06_17005 ENOG4108TZY GntR Family Transcriptional Regulator ATN06_17010 ENOG4105D9R oxidoreductase ATN06_17015 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ATN06_17020 ENOG4105KVH Transcriptional regulator ATN06_17025 ENOG4105KVH Transcriptional regulator ATN06_17070 ENOG4105JAB phenazine biosynthesis protein, phzf family ATN06_17080 ENOG4105CHR reductase ATN06_17095 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ATN06_17100 ENOG4105KVH Transcriptional regulator ATN06_17115 ENOG4108ZJ4 polysaccharide deacetylase ATN06_17140 ENOG4105W1N transcriptional regulator ATN06_17150 ENOG4108IG5 Transcriptional regulator ATN06_17180 ENOG4105KAF membrAne ATN06_17205 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) ATN06_17240 ENOG4105ED2 Beta-lactamase ATN06_17250 ENOG4105H3G oxidoreductase ATN06_17320 ENOG4108TN2 lmbE family ATN06_17330 ENOG4107R3E Citrate transporter ATN06_17345 ENOG4108MES Periplasmic binding protein ATN06_17350 ENOG4105EHG Permease protein ATN06_17355 ENOG4105DQ5 transport system permease protein ATN06_17360 ENOG4105NX3 Membrane ATN06_17375 ENOG41068WN ATN06_17380 ENOG4107CUJ Protein of unknown function (DUF2690) ATN06_17390 ENOG4107V2S Transcriptional regulator ATN06_17400 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ATN06_17415 ENOG4105C98 muts2 protein ATN06_17425 ENOG4105E5K Alpha-amylase ATN06_17430 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase ATN06_17435 ENOG4105DPN Oligoendopeptidase f ATN06_17460 ENOG4105FFC UPF0187 protein ATN06_17475 ENOG4108A04 Beta-lactamase ATN06_17490 ENOG4105EGI Transcriptional regulator ATN06_17500 ENOG4107VXM glycerophosphoryl diester phosphodiesterase ATN06_17525 ENOG41082BM Transcriptional regulator, arsr family ATN06_17530 ENOG4105CB2 alcohol dehydrogenase ATN06_17560 ENOG4105C09 Bile acid ATN06_17565 ENOG4105CQB FAD linked oxidase domain protein ATN06_17580 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) ATN06_17595 ENOG41067SE Tetr family transcriptional regulator ATN06_17600 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity ATN06_17625 ENOG4105BZU Histidine kinase ATN06_17640 ENOG4105KT7 mgtC SapB transporter ATN06_17655 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase ATN06_17660 ENOG4105EAB amino acid AbC transporter ATN06_17670 ENOG4108HW4 amino acid AbC transporter ATN06_17675 ENOG41073R8 VanW family ATN06_17685 ENOG4108R1P ATN06_17700 ENOG4105VEQ Cold shock protein ATN06_17720 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ATN06_17740 ENOG410904N short-chain dehydrogenase reductase ATN06_17750 ENOG4106IQC argininosuccinate lyase ATN06_17765 ENOG4108IA2 Sodium pantothenate symporter ATN06_17775 ENOG4105C26 Dehydrogenase ATN06_17780 ENOG4105CHR reductase ATN06_17790 ENOG4105EWU Squalene--hopene cyclase ATN06_17800 ENOG4105FR1 rard protein ATN06_17805 ENOG410696E Membrane ATN06_17820 ENOG4105D1F ATP-binding protein ATN06_17830 ENOG4108ZAF Molybdopterin ATN06_17835 ENOG4105CVM Molybdenum cofactor synthesis domain protein ATN06_17840 ENOG4105D06 uba thif-type nad fad binding protein ATN06_17845 ENOG4105TMB Formate nitrite transporter ATN06_17855 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ATN06_17860 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) ATN06_17870 ENOG4108JB9 formate dehydrogenase ATN06_17880 ENOG4105E1K spore germination protein ATN06_17945 ENOG4108KGH TRANSCRIPTIONal ATN06_17955 ENOG4105EMN RNA polymerase sigma factor ATN06_17970 ENOG4105CIG ABC transporter ATN06_17990 ENOG4105D9R oxidoreductase ATN06_18000 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ATN06_18010 ENOG4105K4P CoA-binding domain protein ATN06_18015 ENOG4105C0H protease ATN06_18020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_18025 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) ATN06_18030 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase ATN06_18040 ENOG4105W8X HesB YadR YfhF-family protein ATN06_18065 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) ATN06_18070 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ATN06_18080 ENOG4105BZ1 (ABC) transporter ATN06_18085 ENOG4108I0Z Aconitate hydratase ATN06_18115 ENOG4105E5W Transporter ATN06_18125 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ATN06_18145 ENOG4107F3J Amp-dependent synthetase and ligase ATN06_18150 ENOG4107ZYJ bioY protein ATN06_18155 ENOG4105CEY Amp-dependent synthetase and ligase ATN06_18170 ENOG4108IMY Transcriptional regulator ATN06_18215 ENOG4107AYK membrAne ATN06_18225 ENOG4105BZU Histidine kinase ATN06_18230 ENOG4105FBA Phospholipase Carboxylesterase ATN06_18235 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase ATN06_18240 ENOG4105CK7 Sodium proline symporter ATN06_18250 ENOG4105CBC glutamate synthase ATN06_18255 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ATN06_18260 ENOG4108VJ1 Transcriptional regulator (CarD family ATN06_18265 ENOG4108903 Formimidoylglutamase ATN06_18325 ENOG4107QIV Cytochrome c biogenesis protein ATN06_18335 ENOG4105CH2 amidohydrolase ATN06_18345 ENOG4105CJ1 ABC, transporter ATN06_18365 ENOG4107RSM transcriptional regulator ATN06_18375 ENOG41067MG lrgb family ATN06_18400 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase ATN06_18420 ENOG4105BZ1 (ABC) transporter ATN06_18425 ENOG4105BZ1 (ABC) transporter ATN06_18460 ENOG4108HW3 (ABC) transporter ATN06_18465 ENOG4105CGH 5'-nucleotidase ATN06_18475 ENOG4108SVB resolvase ATN06_18495 ENOG4105K7K Transcriptional regulator ATN06_18500 ENOG4105C5F glutamine synthetase ATN06_18505 ENOG4105KV4 Transcriptional regulator ATN06_18510 ENOG4105CXI aluminum resistance protein ATN06_18515 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ATN06_18520 ENOG4105EN6 Membrane ATN06_18530 ENOG4106F1P AAA ATPase, central domain protein ATN06_18560 ENOG41069ER domain protein ATN06_18565 ENOG4105DM4 PTS System ATN06_18570 ENOG4105DE4 1-phosphofructokinase ATN06_18575 ENOG4105E98 transcriptional regulator DeoR family ATN06_18580 ENOG4107QW4 alcohol dehydrogenase ATN06_18585 ENOG4108SJC Membrane ATN06_18600 ENOG4105C85 amino acid ATN06_18615 ENOG4105TMB Formate nitrite transporter ATN06_18620 ENOG4105K70 DNA-binding protein ATN06_18630 ENOG4105C59 p-type ATPase ATN06_18635 ENOG410681U heavy metal transport detoxification protein ATN06_18640 ENOG4105VPX protein, conserved in bacteria ATN06_18650 ENOG4105NIV Esterase ATN06_18655 ENOG4105E0A ABC, transporter ATN06_18675 ENOG4105CGK Exodeoxyribonuclease III ATN06_18685 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ATN06_18690 ENOG4105D03 DNA-3-methyladenine glycosylase II ATN06_18720 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase ATN06_18725 ENOG4105BZU Histidine kinase ATN06_18740 ENOG4107ZY0 Phenazine biosynthesis-like protein ATN06_18750 ENOG41067MG lrgb family ATN06_18765 ENOG4107TTQ Alpha beta hydrolase fold ATN06_18770 ENOG4107YEI lmbE family ATN06_18785 ENOG4108S3Y transcriptional regulator ATN06_18790 ENOG4105CS2 ec 3.2.1.21 ATN06_18805 ENOG4105F0V Cell wall hydrolase ATN06_18820 ENOG410890F Dynamin family ATN06_18830 ENOG4107QHE Choloylglycine hydrolase ATN06_18855 ENOG4105DA5 (ABC) transporter ATN06_18885 ENOG4105DQU oxidoreductase, subunit beta ATN06_18890 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein ATN06_18895 ENOG4108IGT Dipeptidase ATN06_18900 ENOG4105MCT stage V sporulation protein S ATN06_18905 ENOG4105D48 metallophosphoesterase ATN06_18930 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase ATN06_18945 ENOG4105XZV Protein of unknown function (DUF3243) ATN06_18950 ENOG4108RKS Short-chain dehydrogenase reductase Sdr ATN06_18970 ENOG4105UIB (ABC) transporter ATN06_18975 ENOG4108JQ9 ABC transporter ATN06_18980 ENOG4105DIH basic membrane ATN06_18985 ENOG4105FDP GntR family transcriptional regulator ATN06_18990 ENOG4107QZI cell division protein FtsK ATN06_19000 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit ATN06_19015 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ATN06_19025 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ATN06_19030 ENOG4108S0H Dipicolinic acid synthetase, b subunit ATN06_19045 ENOG4105XSJ toxin secretion phage lysis holin ATN06_19105 ENOG4105E35 Dipicolinate synthase subunit A ATN06_19115 ENOG4105C1V Peptidase, M16 ATN06_19135 ENOG4105DTN riboflavin biosynthesis protein ribF ATN06_19150 ENOG4105W7A Protein of unknown function (DUF503) ATN06_19160 ENOG4105VHM ribosomal protein ATN06_19165 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination ATN06_19170 ENOG4105CHV Transcription elongation factor NusA ATN06_19180 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) ATN06_19190 ENOG4105DZP Membrane-associated zinc metalloprotease ATN06_19200 ENOG4105KNE Phosphatidate cytidylyltransferase ATN06_19245 ENOG4108HE4 integrase family ATN06_19255 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ATN06_19260 ENOG4105C79 DNA protecting protein DprA ATN06_19265 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ATN06_19280 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) ATN06_19305 ENOG4105VB6 UPF0109 protein ATN06_19325 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ATN06_19330 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) ATN06_19345 ENOG4105CHR reductase ATN06_19350 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ATN06_19365 ENOG4105CB5 ATP-dependent DNA helicase recG ATN06_19370 ENOG4105DP4 dak2 domain fusion protein ylov ATN06_19375 ENOG4108ZAA Alkaline-shock protein ATN06_19390 ENOG4105FJ0 thiamine ATN06_19395 ENOG4105DJV ribulose-phosphate 3-epimerase ATN06_19405 ENOG4105D9P serine threonine protein kinase ATN06_19410 ENOG4108ZF3 Phosphatase ATN06_19420 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ATN06_19430 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ATN06_19435 ENOG4105C25 Primosomal protein n' ATN06_19440 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ATN06_19460 ENOG4105DSJ YicC domain protein ATN06_19470 ENOG4105F23 Fibronectin-binding protein ATN06_19480 ENOG4105DC7 peptidase M24 ATN06_19530 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) ATN06_19565 ENOG4105C34 Pseudouridine synthase ATN06_19590 ENOG4105DBK s4 domain protein ATN06_19595 ENOG41067XK integral membrane protein ATN06_19600 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) ATN06_19605 ENOG4105DFA alanine racemase domain protein ATN06_19610 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ATN06_19615 ENOG4105WR5 sporulation protein, YlmC YmxH family ATN06_19625 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ATN06_19635 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ATN06_19640 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ATN06_19645 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) ATN06_19655 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ATN06_19660 ENOG4105CNI cell division protein FtsW ATN06_19675 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ATN06_19680 ENOG4105CJN penicillin-binding protein ATN06_19685 ENOG4105CJN penicillin-binding protein ATN06_19690 ENOG41068DC Essential cell division protein (By similarity) ATN06_19725 ENOG4105KNH Nucleic acid-binding protein ATN06_19735 ENOG41063PX domain protein ATN06_19740 ENOG4105D78 K07001 NTE family protein ATN06_19745 ENOG4105H20 Sporulation integral membrane protein YlbJ ATN06_19755 ENOG4106H78 methyltransferase ATN06_19775 ENOG4107TB6 phosphoglycerate mutase ATN06_19790 ENOG4106UY4 Inherit from COG: Scp-like extracellular ATN06_19835 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) ATN06_19840 ENOG4105CNI cell division protein FtsW ATN06_19855 ENOG4108IAB Phoh family ATN06_19875 ENOG4105QA2 ATN06_19880 ENOG4105CI3 gtp-binding protein typa ATN06_19890 ENOG4105ECY inositol monophosphatase ATN06_19910 ENOG4105CXN decarboxylase ATN06_19955 ENOG4105C7S Dehydrogenase ATN06_19960 ENOG4105CPP Dehydrogenase, E1 component ATN06_19975 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ATN06_19980 ENOG4108X4Q Hydrolase ATN06_19990 ENOG4105CN5 Metallo-Beta-Lactamase ATN06_19995 ENOG4107ZYR domain protein ATN06_20030 ENOG4108XRC Protein of unknown function (DUF458) ATN06_20040 ENOG4107IN1 Protein of unknown function (DUF1797) ATN06_20055 ENOG4105EPM Diguanylate phosphodiesterase ATN06_20060 ENOG4105K6S Short-chain dehydrogenase reductase Sdr ATN06_20075 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ATN06_20085 ENOG4105UIN ATN06_20150 ENOG4108HGU Histidine kinase ATN06_20160 ENOG4105CHM Aminotransferase ATN06_20165 ENOG4105FKQ transcriptional regulator ATN06_20170 ENOG4105EG2 ABC transporter, permease ATN06_20180 ENOG4107FKK extracellular solute-binding protein family 1 ATN06_20190 ENOG4105CG3 alpha amylase, catalytic region ATN06_20240 ENOG4105CHU acetyl-coa acetyltransferase ATN06_20275 ENOG4105K7K Transcriptional regulator ATN06_20280 ENOG4105DTD Dehydrogenase ATN06_20300 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ATN06_20340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ATN06_20350 ENOG4105BZU Histidine kinase ATN06_20370 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ATN06_20385 ENOG4105CID antiterminator ATN06_20395 ENOG4105FDP GntR family transcriptional regulator ATN06_20405 ENOG4105CE4 GlcNAc 6-P deacetylase ATN06_20450 ENOG4107ZE5 PPIases accelerate the folding of proteins ATN06_20455 ENOG4105PTM secreted protein ATN06_20460 ENOG4105J7I hydrolase ATN06_20470 ENOG4105G6R Stage v sporulation protein ae ATN06_20480 ENOG4105CZ3 stage V sporulation protein ad ATN06_20485 ENOG41090VF Stage v sporulation protein ac ATN06_20505 ENOG4105C8J )-transporter ATN06_20510 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ATN06_20520 ENOG41082AN stage II sporulation protein ATN06_20525 ENOG4105DZ1 carboxypeptidase ATN06_20530 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family ATN06_20535 ENOG4105DVE abc transporter atp-binding protein ATN06_20575 ENOG4105D7N magnesium and cobalt transport protein CorA ATN06_20600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ATN06_20610 ENOG4105I3K Ferric uptake regulator, Fur family ATN06_20615 ENOG4105MZ9 stage II sporulation protein m ATN06_20635 ENOG4105CPC Aldo Keto reductase ATN06_20645 ENOG4105RHY Pfam:UPF0157 ATN06_20665 ENOG4107SKW Inherit from COG: Alpha beta hydrolase ATN06_20675 ENOG4105ETE Transcriptional regulator (LacI family ATN06_20680 ENOG4108YM7 Gcn5-related n-acetyltransferase ATN06_20700 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ATN06_20705 ENOG4108R6K riboflavin synthase, subunit alpha ATN06_20730 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ATN06_20735 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ATN06_20740 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ATN06_20750 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ATN06_20760 ENOG4105DFD Na H antiporter ATN06_20765 ENOG4105CGH 5'-nucleotidase ATN06_20820 ENOG4108IXY short-chain dehydrogenase reductase ATN06_20825 ENOG41069FQ Metallo-beta-lactamase superfamily ATN06_20830 ENOG4105II7 pyrroline-5-carboxylate reductase ATN06_20835 ENOG4105EJQ L-serine dehydratase ATN06_20870 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic ATN06_20880 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ATN06_20890 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ATN06_20895 ENOG4105D9U N-acetyltransferase ATN06_20910 ENOG4108VZI ErfK ybiS ycfS ynhG family protein ATN06_20915 ENOG4108QEG Membrane ATN06_20920 ENOG4105CDA abc transporter atp-binding protein ATN06_20925 ENOG4105E5Q amino acid AbC transporter ATN06_20930 ENOG4108HW3 (ABC) transporter ATN06_20940 ENOG4105G7B Protein of unknown function (DUF2992) ATN06_20950 ENOG4108QY0 Membrane ATN06_20965 ENOG4105C7S Dehydrogenase ATN06_20970 ENOG4105CPP Dehydrogenase, E1 component ATN06_20985 ENOG4105CKM Branched-chain carboxylic acid kinase ATN06_20990 ENOG4107RDP Dehydrogenase ATN06_21005 ENOG4108JUB Transcriptional regulator ATN06_21015 ENOG4108QXE glycerophosphoryl diester phosphodiesterase ATN06_21040 ENOG4107QQR Sporulation ATN06_21050 ENOG4105S1Z Stage IV sporulation protein B ATN06_21055 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ATN06_21065 ENOG4105DX0 Hemolysin A ATN06_21075 ENOG4105CTB Polyprenyl synthetase ATN06_21100 ENOG4108ZSR alkaline shock protein ATN06_21105 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ATN06_21130 ENOG410644B Stage III sporulation protein af ATN06_21140 ENOG4105KQ4 Stage iii sporulation protein ad ATN06_21145 ENOG4108CQH stage III sporulation protein AC ATN06_21150 ENOG4105KR5 Stage iii sporulation protein ATN06_21155 ENOG4105CD2 stage iii sporulation protein aa ATN06_21175 ENOG4105DC7 peptidase M24 ATN06_21190 ENOG4105CBJ Metal-dependent enzyme ATN06_21200 ENOG4107YBY Hydrolase ATN06_21230 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) ATN06_21235 ENOG4105WZW rhodanese family ATN06_21260 ENOG41080TC multidrug resistance protein ATN06_21305 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family ATN06_21320 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ATN06_21335 ENOG4105C0D helicase ATN06_21455 ENOG4105C3R Methionine synthase ATN06_21470 ENOG4105C28 cystathionine ATN06_21475 ENOG4105C28 cystathionine ATN06_21495 ENOG4105C5X domain protein ATN06_21505 ENOG4105DKQ ROK family ATN06_21515 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ATN06_21530 ENOG4108UTW Plays a role in the regulation of phosphate uptake ATN06_21535 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ATN06_21540 ENOG4105E2Z phosphate ABC transporter (Permease ATN06_21545 ENOG4105C8U phosphate abc transporter ATN06_21550 ENOG4105PWN phosphate abc transporter ATN06_21555 ENOG4107RF6 penicillin-binding protein ATN06_21565 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ATN06_21590 ENOG4105N80 Ferric uptake regulator, Fur family ATN06_21600 ENOG4105FDK ABC transporter ATN06_21605 ENOG4108JYZ YitT family ATN06_21610 ENOG41069ZM Protein of unknown function (DUF2624) ATN06_21635 ENOG4105EGD dinuclear metal center protein, YbgI family ATN06_21650 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ATN06_21655 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ATN06_21690 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ATN06_21695 ENOG4105KG3 cytidine deaminase ATN06_21700 ENOG4107YR5 Diacylglycerol kinase ATN06_21710 ENOG4105CTJ Metal Dependent Phosphohydrolase ATN06_21715 ENOG4105C9A Phoh family ATN06_21730 ENOG41068P3 sporulation protein YqfC ATN06_21735 ENOG4105KTH gatB Yqey ATN06_21745 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ATN06_21750 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ATN06_21780 ENOG4105CSA Coproporphyrinogen iii oxidase ATN06_21785 ENOG4105KVH Transcriptional regulator ATN06_21810 ENOG4105TQK DNA polymerase iii, delta' subunit ATN06_21820 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 ATN06_21825 ENOG4108UK2 deaminase ATN06_21830 ENOG4105KQC Competence protein ATN06_21840 ENOG4105DXX methyltransferase ATN06_21850 ENOG4108WF2 Metal Dependent Phosphohydrolase ATN06_21860 ENOG410812S Rna-binding protein ATN06_21870 ENOG4105CQW ribosome biogenesis GTPase YqeH ATN06_21875 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase ATN06_21890 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ATN06_21910 ENOG4108TVJ Nitroreductase ATN06_21925 ENOG4105G6Z alkaline phosphatase ATN06_21935 ENOG4108MUZ hydrolase ATN06_21970 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin ATN06_21975 ENOG4105MIR Phenylalanine 4-monooxygenase ATN06_21985 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase ATN06_22025 ENOG4105S6R Iron-hydroxamate transporter permease subunit ATN06_22030 ENOG4108HUF Transporter ATN06_22040 ENOG4108EKI Dehydrogenase ATN06_22045 ENOG4105C28 cystathionine ATN06_22055 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ATN06_22075 ENOG4107XRG penicillin-binding protein ATN06_22095 ENOG4105CFP Peptidase U32 ATN06_22100 ENOG4105XYU peptidase (U32 family) ATN06_22105 ENOG4108VQJ O-methyltransferase ATN06_22110 ENOG4105HHA aminodeoxychorismate lyase ATN06_22140 ENOG4105C02 permease ATN06_22155 ENOG41060CR ATN06_22160 ENOG4105C7H Helicase, RecD TraA family ATN06_22170 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ATN06_22175 ENOG4105C3J Cysteine desulfurase ATN06_22185 ENOG4105D1H recombination factor protein RarA ATN06_22190 ENOG4108VCI transcription factor, rsfa family ATN06_22200 ENOG4105CUZ uba thif-type nad fad binding protein ATN06_22210 ENOG4105CUT histidyl-tRNA synthetase ATN06_22230 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ATN06_22240 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ATN06_22245 ENOG41076HS cation diffusion facilitator family transporter ATN06_22250 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ATN06_22260 ENOG4105CKP Polysaccharide Biosynthesis Protein ATN06_22265 ENOG4108QG2 Membrane ATN06_22275 ENOG4105VIE preprotein translocase, subunit YajC ATN06_22290 ENOG41061AI Protein of unknown function (DUF2905) ATN06_22305 ENOG4108HUF Transporter ATN06_22315 ENOG4108IPJ Membrane ATN06_22320 ENOG41082BM Transcriptional regulator, arsr family ATN06_22345 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ATN06_22350 ENOG4108IYU L-aspartate oxidase ATN06_22365 ENOG4108RPX mosc domain containing protein ATN06_22370 ENOG4105CQC Prephenate dehydratase ATN06_22385 ENOG4105C19 ABC transporter ATN06_22390 ENOG4105EWM Histidine kinase ATN06_22400 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ATN06_22415 ENOG4105X36 (ribosomal) protein ATN06_22425 ENOG4105C03 ribonuclease ATN06_22440 ENOG4107QMS site-determining protein ATN06_22455 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ATN06_22460 ENOG4105DFF Rod shape-determining protein mreb ATN06_22480 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ATN06_22495 ENOG41068KH stage VI sporulation protein D ATN06_22505 ENOG4105D52 delta-aminolevulinic acid dehydratase ATN06_22530 ENOG4105K56 Transcriptional regulator ATN06_22550 ENOG4108IUQ atp-dependent protease ATN06_22575 ENOG4108QCI YvbH-like oligomerisation region ATN06_22600 ENOG4105M59 Phosphodiesterase, mj0936 family ATN06_22615 ENOG4108XJQ germination protein ATN06_22625 ENOG4105C0R drug resistance transporter emrb qaca subfamily ATN06_22635 ENOG4105KBX Transcriptional regulator, TetR family ATN06_22650 ENOG4105PFC Transcriptional regulator ATN06_22660 ENOG4105DZC cytosine deaminase ATN06_22665 ENOG41067S9 phage shock protein C, PspC ATN06_22670 ENOG4108JCI Transcriptional regulator ATN06_22680 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ATN06_22685 ENOG4108Z40 Transcriptional regulator ATN06_22690 ENOG4105RHA ABC transporter, permease ATN06_22695 ENOG4108IUX (ABC) transporter ATN06_22700 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family ATN06_22705 ENOG4105ER2 Ompa motb domain protein ATN06_22710 ENOG4105E14 MotA TolQ exbB proton channel ATN06_22715 ENOG4108VXD carboxy-peptidase ATN06_22725 ENOG4105E33 succinate dehydrogenase ATN06_22735 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit ATN06_22750 ENOG4105K63 Thioredoxin ATN06_22755 ENOG4105C10 Electron transfer flavoprotein ATN06_22760 ENOG4105BZJ Electron transfer flavoprotein ATN06_22765 ENOG41060WC Enoyl-CoA hydratase ATN06_22770 ENOG4107Z3H Transcriptional regulator, TetR family ATN06_22775 ENOG4105CEY Amp-dependent synthetase and ligase ATN06_22825 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ATN06_22840 ENOG4105DR4 Methyltransferase ATN06_22850 ENOG4105KFN sortase, SrtB family ATN06_22855 ENOG4105E0A ABC, transporter ATN06_22870 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) ATN06_22880 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) ATN06_22890 ENOG4105FE9 pseudouridine synthase ATN06_22910 ENOG4105DCG PHP domain protein ATN06_22925 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ATN06_22945 ENOG4105C5S asparaginyl-tRNA synthetase ATN06_22950 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ATN06_22960 ENOG4108RWN rrna methyltransferase ATN06_23000 ENOG4105C0R drug resistance transporter emrb qaca subfamily ATN06_23005 ENOG4105CW7 secretion protein, HlyD family ATN06_23010 ENOG4108JGH Tetr family transcriptional regulator ATN06_23015 ENOG4105CN9 Peptidase m42 family protein ATN06_23035 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ATN06_23040 ENOG4105C22 threonyL-tRNA synthetase ATN06_23045 ENOG4108TDW sporulation protein YtxC ATN06_23065 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) ATN06_23070 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ATN06_23075 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ATN06_23085 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ATN06_23090 ENOG4105C2M dna polymerase I ATN06_23095 ENOG4105BZU Histidine kinase ATN06_23100 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ATN06_23120 ENOG4108HMX isocitrate dehydrogenase (NADP) ATN06_23125 ENOG4105BZN citrate synthase ATN06_23140 ENOG4108REF Sporulation integral membrane protein ytvi ATN06_23145 ENOG4105FS0 cytoplasmic membrane protein ATN06_23150 ENOG4105CA9 Pyruvate kinase ATN06_23170 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family ATN06_23175 ENOG4105C6K Malic enzyme ATN06_23180 ENOG4105C0B DNA polymerase III (alpha subunit) ATN06_23185 ENOG4105VV2 ATN06_23195 ENOG4105SFS phosphoesterase RecJ domain protein ATN06_23235 ENOG4105DC7 peptidase M24 ATN06_23275 ENOG4105Z7P Acetyltransferase (GNAT) family ATN06_23280 ENOG41082W1 Cupin 2, conserved barrel domain protein ATN06_23290 ENOG4105VZ8 Transcriptional regulator ATN06_23310 ENOG4107YZX Universal stress protein ATN06_23350 ENOG4108JYZ YitT family ATN06_23370 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ATN06_23380 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ATN06_23385 ENOG4105KBJ sporulation protein ytfj ATN06_23400 ENOG4105EFZ amidohydrolase ATN06_23410 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ATN06_23450 ENOG4105U5Y Transcriptional regulator ATN06_23460 ENOG4105C28 cystathionine ATN06_23465 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ATN06_23510 ENOG4105EMN RNA polymerase sigma factor ATN06_23530 ENOG4105F1V Acetoin utilization protein ATN06_23535 ENOG4105W87 Cbs domain ATN06_23540 ENOG4105DGU Histone deacetylase ATN06_23555 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ATN06_23565 ENOG4107SNB ankyrin repeat protein YahD ATN06_23570 ENOG4105EP9 oxidoreductase ATN06_23600 ENOG4105ETE Transcriptional regulator (LacI family ATN06_23625 ENOG4105C88 aminopeptidase ATN06_23655 ENOG4108IPJ Membrane ATN06_23665 ENOG4105K7K Transcriptional regulator ATN06_23700 ENOG4108VDD TRNA binding domain protein ATN06_23730 ENOG4105C8F Beta-lactamase domain protein ATN06_23745 ENOG4108V15 phosphotransferase enzyme family ATN06_23750 ENOG4108IUM Glycogen debranching enzyme ATN06_23765 ENOG4107QSE Dipeptidase ATN06_23770 ENOG4105YW5 deoR family transcriptional regulator ATN06_23785 ENOG4105CBX hi0933 family ATN06_23820 ENOG4108VJ1 Transcriptional regulator (CarD family ATN06_23825 ENOG4107EXU Short-chain dehydrogenase reductase Sdr ATN06_23845 ENOG4108ZAF Molybdopterin ATN06_23850 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein ATN06_23855 ENOG4105CVM Molybdenum cofactor synthesis domain protein ATN06_23865 ENOG4105D06 uba thif-type nad fad binding protein ATN06_23870 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ATN06_23890 ENOG41085GJ domain protein ATN06_23900 ENOG4105DWV Homoserine O-trans-acetylase ATN06_23910 ENOG4108B31 Spore germination protein ATN06_23945 ENOG410605W Major Facilitator ATN06_23950 ENOG4107S91 Sodium hydrogen exchanger ATN06_23955 ENOG4105NCW Trka-c domain protein ATN06_23970 ENOG4105C19 ABC transporter ATN06_23990 ENOG4105N5T Radical SAM Protein ATN06_24000 ENOG4105DA5 (ABC) transporter ATN06_24030 ENOG4105E8V Alpha Beta Hydrolase Fold protein ATN06_24035 ENOG4108Z0R Transferase ATN06_24040 ENOG4105YVM Phosphoesterase, PA-phosphatase related ATN06_24045 ENOG4105BZF Glycosyl transferase (Group 1 ATN06_24055 ENOG4108RIR Molybdenum cofactor biosynthesis protein ATN06_24080 ENOG4108MK9 spermidine N(1)-acetyltransferase ATN06_24130 ENOG4105BZU Histidine kinase ATN06_24135 ENOG4105BZU Histidine kinase ATN06_24140 ENOG4107S9D Alpha beta hydrolase ATN06_24145 ENOG4107T7U Sulfatase ATN06_24160 ENOG4105D2X ABC transporter substrate-binding protein ATN06_24170 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component ATN06_24225 ENOG4108V2W Carbonate dehydratase ATN06_24230 ENOG4105C4M (Ubiquinol oxidase) subunit I ATN06_24235 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ATN06_24285 ENOG41087YS Phage shock protein A ATN06_24315 ENOG4105BZU Histidine kinase ATN06_24320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_24345 ENOG4108UGV hypoxanthine phosphoribosyltransferase ATN06_24350 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) ATN06_24385 ENOG4107ZTW SNARE associated Golgi ATN06_24410 ENOG4105C19 ABC transporter ATN06_24415 ENOG41086D8 Transcriptional regulator ATN06_24425 ENOG41082BM Transcriptional regulator, arsr family ATN06_24475 ENOG4105C6Z Gluconate ATN06_24480 ENOG4105FDP GntR family transcriptional regulator ATN06_24500 ENOG41069H0 dihydroorotase EC 3.5.2.3 ATN06_24520 ENOG4105DTQ mandelate racemase muconate lactonizing ATN06_24530 ENOG4108IPT Naphthoate synthase ATN06_24535 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) ATN06_24545 ENOG4105E4F Isochorismate synthase ATN06_24550 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ATN06_24560 ENOG4105VEQ Cold shock protein ATN06_24570 ENOG4108Z40 Transcriptional regulator ATN06_24620 ENOG4105D7V transposase ATN06_24630 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ATN06_24640 ENOG4105JVQ RNA Polymerase ATN06_24790 ENOG4105KT7 mgtC SapB transporter ATN06_24795 ENOG4107PBV potassium channel ATN06_24815 ENOG4105WG9 Conserved Protein ATN06_24825 ENOG4105CHM Aminotransferase ATN06_24830 ENOG4108ZB6 transcriptional regulator AsnC family ATN06_24835 ENOG4105C5I Dehydrogenase ATN06_24840 ENOG4108MUZ hydrolase ATN06_24850 ENOG4105C87 Aminotransferase class I and II ATN06_24865 ENOG4105Y38 Kinase-associated protein B ATN06_24875 ENOG4107R3E Citrate transporter ATN06_24890 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) ATN06_24895 ENOG4105KA0 thioesterase Superfamily protein ATN06_24915 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ATN06_24935 ENOG41069ER domain protein ATN06_24950 ENOG4105CEP NADH dehydrogenase ATN06_24975 ENOG4105EWC Purine nucleoside phosphorylase ATN06_25010 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ATN06_25035 ENOG4105C19 ABC transporter ATN06_25040 ENOG4105C4B ABC transporter, permease ATN06_25045 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ATN06_25070 ENOG41083MR nifu domain-containing protein ATN06_25085 ENOG4108W5N phosphatidylglycerophosphatase a ATN06_25100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ATN06_25105 ENOG4105DYS nad(p)h dehydrogenase (quinone) ATN06_25115 ENOG4105D4U had-superfamily hydrolase, subfamily iia ATN06_25130 ENOG4105CBT Fructose-1,6-bisphosphatase ATN06_25150 ENOG4105MMD transcriptional regulator ATN06_25155 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) ATN06_25160 ENOG4107TXC Transcriptional regulator ATN06_25165 ENOG41090T1 Membrane ATN06_25190 ENOG4105FAA peptidase M23 ATN06_25200 ENOG4105KZD Domain of unknown function (DUF1805) ATN06_25205 ENOG4107R8B 5'-nucleotidase ATN06_25220 ENOG4105DIW FeS assembly protein SUFB ATN06_25225 ENOG4108UNV SUF system FeS assembly protein, NifU family ATN06_25230 ENOG4105C9B Cysteine desulfurase ATN06_25235 ENOG4105JRK feS assembly protein SufD ATN06_25240 ENOG4105C3K feS assembly ATPase SufC ATN06_25245 ENOG4105D01 (LipO)protein ATN06_25250 ENOG4105D01 (LipO)protein ATN06_25255 ENOG4108UMI ABC transporter, permease ATN06_25285 ENOG41080E8 Transcriptional regulator, Spx MgsR family ATN06_25340 ENOG4108W8B Beta-lactamase domain protein ATN06_25345 ENOG4105C1G acyl-Coa dehydrogenase ATN06_25350 ENOG4105CHU acetyl-coa acetyltransferase ATN06_25365 ENOG4105DZ1 carboxypeptidase ATN06_25385 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer ATN06_25405 ENOG4105F27 Major Facilitator ATN06_25410 ENOG4107R7I amino acid ATN06_25425 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ATN06_25435 ENOG4107AYK membrAne ATN06_25465 ENOG4107ZTW SNARE associated Golgi ATN06_25475 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ATN06_25480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_25485 ENOG4105BZU Histidine kinase ATN06_25510 ENOG4105C8Q Methyl-accepting chemotaxis ATN06_25515 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer ATN06_25520 ENOG4105VG1 fes assembly suf system protein ATN06_25525 ENOG4105D4Y metalloprotease ATN06_25545 ENOG4107T5V SNARE associated Golgi ATN06_25550 ENOG4107S91 Sodium hydrogen exchanger ATN06_25555 ENOG4105NCW Trka-c domain protein ATN06_25570 ENOG4108RMU ferritin dps family protein ATN06_25580 ENOG4108URH decarboxylase ATN06_25600 ENOG4105D9N nucleoside ATN06_25605 ENOG4105D9N nucleoside ATN06_25620 ENOG4108RYK Nad-dependent epimerase dehydratase ATN06_25630 ENOG4105CV8 reductase ATN06_25635 ENOG4105F27 Major Facilitator ATN06_25640 ENOG4105KVH Transcriptional regulator ATN06_25655 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ATN06_25660 ENOG4105D4A Cell wall formation (By similarity) ATN06_25670 ENOG4105C8Q Methyl-accepting chemotaxis ATN06_25680 ENOG4105WMR Protein CrcB homolog ATN06_25685 ENOG4105WMR Protein CrcB homolog ATN06_25700 ENOG4108MK9 spermidine N(1)-acetyltransferase ATN06_25705 ENOG4108VY7 phosphate-starvation-inducible protein PsiE ATN06_25730 ENOG4108IPW abc transporter atp-binding protein ATN06_25735 ENOG4105CM4 permease protein ATN06_25760 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ATN06_25770 ENOG4105XZU Preprotein translocase, subunit SecG ATN06_25775 ENOG41067MG lrgb family ATN06_25825 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ATN06_25875 ENOG41090VF Stage v sporulation protein ac ATN06_25880 ENOG4105CZ3 stage V sporulation protein ad ATN06_25895 ENOG4108QY0 Membrane ATN06_25900 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ATN06_25905 ENOG4105KRI phosphocarrier protein (HPr ATN06_25915 ENOG4105CHW UPF0052 protein ATN06_25925 ENOG4108Z4K mutator MutT protein ATN06_25935 ENOG4105C3M thioredoxin reductase ATN06_25945 ENOG4108S4C acetyltransferase ATN06_25965 ENOG41086DT Membrane protein of unknown function ATN06_25975 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ATN06_25995 ENOG4107TXC Transcriptional regulator ATN06_26025 ENOG4105DUM transcriptional regulator, lysR family ATN06_26035 ENOG4108WS4 fmn reductase ATN06_26050 ENOG4105BZ1 (ABC) transporter ATN06_26060 ENOG4105CN1 protease ATN06_26065 ENOG4105CRP Part of the ABC transporter FtsEX involved in ATN06_26070 ENOG4105CAK Cell division ATP-binding protein ftsE ATN06_26085 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ATN06_26095 ENOG4105MS2 ribosomal subunit Interface protein ATN06_26100 ENOG4105VEQ Cold shock protein ATN06_26105 ENOG41081UC Inherit from COG: Competence protein ATN06_26120 ENOG4105KVH Transcriptional regulator ATN06_26135 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ATN06_26140 ENOG4108KGH TRANSCRIPTIONal ATN06_26145 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ATN06_26150 ENOG4105C6Y Udp-glucose 6-dehydrogenase ATN06_26155 ENOG4105ESV Glycosyl transferase, family 4 ATN06_26165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ATN06_26185 ENOG4105F8D glycoside hydrolase family 4 ATN06_26190 ENOG4105VCP PTS System ATN06_26195 ENOG4105CK1 PTS System ATN06_26205 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) ATN06_26215 ENOG4105VCP PTS System ATN06_26225 ENOG4105VZJ PTS System ATN06_26240 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase ATN06_26245 ENOG4105ECB domain protein ATN06_26250 ENOG4107RSM transcriptional regulator ATN06_26285 ENOG4105DAA L-lactate ATN06_26295 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) ATN06_26305 ENOG4105E0M Sulfatase ATN06_26330 ENOG4107R8N Glycosyl transferase, family 2 ATN06_26340 ENOG4105C94 Transporter ATN06_26345 ENOG41069ER domain protein ATN06_26370 ENOG4105KBK Zinc finger, swim domain protein ATN06_26375 ENOG4105C0D helicase ATN06_26405 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ATN06_26415 ENOG4107RBB ABC transporter, permease ATN06_26420 ENOG4105C19 ABC transporter ATN06_26430 ENOG4105CXY transporter ATN06_26450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_26455 ENOG4105CMR udp-glucose 4-epimerase ATN06_26465 ENOG4107VDP teichoic acid biosynthesis ATN06_26480 ENOG4105EY8 ABC transporter ATN06_26490 ENOG4107SJB teichoic acid biosynthesis ATN06_26495 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ATN06_26500 ENOG4107SJB teichoic acid biosynthesis ATN06_26510 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase ATN06_26520 ENOG4105MT0 Sporulation transcriptional regulator spoiiid ATN06_26530 ENOG4105FRN stage II sporulation protein ATN06_26545 ENOG4105DY9 regulatoR ATN06_26550 ENOG4105CEY Amp-dependent synthetase and ligase ATN06_26570 ENOG4106778 Protein of unknown function (DUF1146) ATN06_26575 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ATN06_26580 ENOG4105C8S subunit m ATN06_26585 ENOG4105D65 subunit l ATN06_26610 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ATN06_26615 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ATN06_26625 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ATN06_26630 ENOG4105BZU Histidine kinase ATN06_26660 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ATN06_26680 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) ATN06_26685 ENOG41062M3 atp synthase ATN06_26715 ENOG4108YZG isomerase ATN06_26730 ENOG4108VGI doxx family ATN06_26735 ENOG4107XC4 flavin reductase domain protein, FMN-binding ATN06_26750 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ATN06_26760 ENOG4108ZXQ stage ii sporulation protein r ATN06_26765 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ATN06_26770 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ATN06_26775 ENOG4107104 thymidine kinase ATN06_26785 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ATN06_26790 ENOG4105CBT Fructose-1,6-bisphosphatase ATN06_26795 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ATN06_26830 ENOG4105C1G acyl-Coa dehydrogenase ATN06_26835 ENOG4105C1G acyl-Coa dehydrogenase ATN06_26840 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ATN06_26850 ENOG4105DF6 Fe-S oxidoreductase ATN06_26865 ENOG4105BZU Histidine kinase ATN06_26885 ENOG4105BZU Histidine kinase ATN06_26890 ENOG4105KCT ABC transporter ATN06_26895 ENOG4108M15 ABC transporter ATN06_26900 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) ATN06_26910 ENOG4105IIU Aminopeptidase ATN06_26945 ENOG4105EMN RNA polymerase sigma factor ATN06_26955 ENOG410684U Domain of unknown function (DUF1934) ATN06_26975 ENOG4105CYW agmatinase ATN06_26985 ENOG4105DXB Major Facilitator superfamily ATN06_26990 ENOG4107SWG transcriptional regulator MERR family ATN06_26995 ENOG4108QXE glycerophosphoryl diester phosphodiesterase ATN06_27000 ENOG4105BZ4 penicillin-binding protein ATN06_27005 ENOG4108XFG YwhD family ATN06_27010 ENOG4108Z4T Peptidase M50 ATN06_27015 ENOG41069HH 4-oxalocrotonate tautomerase ATN06_27020 ENOG4105DCI Phosphohydrolase ATN06_27025 ENOG4108MES Periplasmic binding protein ATN06_27030 ENOG4105E0A ABC, transporter ATN06_27035 ENOG4105EHG Permease protein ATN06_27040 ENOG4105DQ5 transport system permease protein ATN06_27050 ENOG4108VCI transcription factor, rsfa family ATN06_27055 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) ATN06_27060 ENOG4108IJ2 phosphate acetyltransferase ATN06_27065 ENOG4107UEZ chlorite dismutase ATN06_27075 ENOG4108VKI Cell wall hydrolase ATN06_27095 ENOG4107SVH Potassium channel protein ATN06_27105 ENOG410667J hydrolase ATN06_27110 ENOG4105VCH membrane ATN06_27120 ENOG4108TU7 Inherit from COG: (ABC) transporter ATN06_27125 ENOG4105CJ1 ABC, transporter ATN06_27130 ENOG41090WU lipolytic protein G-D-S-L family ATN06_27145 ENOG4105D6E homoserine dehydrogenase ATN06_27170 ENOG4108Y4K DNA-binding transcriptional activator ATN06_27180 ENOG4105WH1 Two component transcriptional regulator luxr family ATN06_27185 ENOG4105BZU Histidine kinase ATN06_27190 ENOG4105DWF phosphomethylpyrimidine kinase ATN06_27195 ENOG4105BZU Histidine kinase ATN06_27200 ENOG4105VCD cytoplasmic protein ATN06_27205 ENOG4105D22 carbon starvation protein ATN06_27210 ENOG4105DY9 regulatoR ATN06_27215 ENOG41079KZ Major Facilitator Superfamily ATN06_27235 ENOG4105EN6 Membrane ATN06_27240 ENOG4106YBV Methyl-accepting chemotaxis ATN06_27250 ENOG4108S4H thioesterase Superfamily protein ATN06_27260 ENOG4105JEU Glycosyl transferase, family 2 ATN06_27265 ENOG4105C5H ABC transporter ATN06_27280 ENOG4105CKK Glycosyl transferase, family 2 ATN06_27285 ENOG41067SE Tetr family transcriptional regulator ATN06_27295 ENOG4105E0X reductase ATN06_27300 ENOG4106F5Q Membrane ATN06_27315 ENOG4108NEV two component transcriptional regulator, LytTR family ATN06_27320 ENOG4108HRK Histidine kinase ATN06_27325 ENOG4107RGD Major Facilitator superfamily ATN06_27340 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ATN06_27350 ENOG4105IW1 AmiS UreI transporter ATN06_27360 ENOG4105CMR udp-glucose 4-epimerase ATN06_27365 ENOG4108UT2 hemolysin iii ATN06_27375 ENOG4105C1J atp-dependent rna helicase ATN06_27420 ENOG4105C0H protease ATN06_27425 ENOG4105Q2H domain protein ATN06_27440 ENOG4105BZU Histidine kinase ATN06_27445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ATN06_27475 ENOG4105CDU Replicative dna helicase ATN06_27485 ENOG4105BZR domain protein ATN06_27490 ENOG4108XMW Membrane ATN06_27500 ENOG4108UUM single-stranded DNA-binding protein ATN06_27510 ENOG4105C3G gtp-binding protein ATN06_27515 ENOG4105VDK protein, conserved in bacteria ATN06_27520 ENOG4105D8X mechanosensitive ion channel ATN06_27525 ENOG4108ZDA Sporulation protein YyaC ATN06_27530 ENOG4105FA0 parb-like partition protein ATN06_27535 ENOG4107QJE Chromosome Partitioning Protein ATN06_27565 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ATN06_27585 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ATN06_27590 ENOG410848D S4 domain protein YaaA ATN06_27605 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)