locus-tag class description FOC85_00030 ENOG41060SN FOC85_00115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC85_00155 ENOG4107QJE Chromosome Partitioning Protein FOC85_00220 ENOG4105WXW Antirepressor FOC85_00250 ENOG4106CVF DNA replication protein FOC85_00325 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC85_00350 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC85_00355 ENOG4108TFU terminase (Small subunit) FOC85_00365 ENOG4108MDF Phage Portal Protein FOC85_00370 ENOG4106CGH Phage Mu protein F like protein FOC85_00405 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_00410 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_00420 ENOG4107258 Transcriptional regulator FOC85_00430 ENOG4105E0Y RtcB Protein FOC85_00435 ENOG4105ECK Fatty Acid Desaturase FOC85_00450 ENOG4105VMP Transcriptional regulator FOC85_00465 ENOG41090T1 Membrane FOC85_00475 ENOG4108WCX response regulator FOC85_00485 ENOG41068WN FOC85_00525 ENOG4105CSH Transporter FOC85_00535 ENOG4105CKK Glycosyl transferase, family 2 FOC85_00550 ENOG4105CKK Glycosyl transferase, family 2 FOC85_00560 ENOG4105C8Y Acetylornithine aminotransferase FOC85_00565 ENOG4105CH6 catalase FOC85_00605 ENOG4108TVJ Nitroreductase FOC85_00610 ENOG4105FS7 Transcriptional regulator FOC85_00645 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC85_00665 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC85_00695 ENOG4108XET gCN5-related N-acetyltransferase FOC85_00755 ENOG410635A Membrane FOC85_00760 ENOG4105KNA -acetyltransferase FOC85_00765 ENOG4108IQI permease FOC85_00775 ENOG4105F1N DNA alkylation repair FOC85_00805 ENOG4107RF6 penicillin-binding protein FOC85_00840 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC85_00845 ENOG4107258 Transcriptional regulator FOC85_00855 ENOG4106N3A copper homeostasis protein cutc FOC85_00860 ENOG4108ZRV stage ii sporulation protein p FOC85_00865 ENOG4108ZHR arsR family transcriptional regulator FOC85_00875 ENOG4105FDT acyl-CoA dehydrogenase FOC85_00890 ENOG4105DWD nucleoside recognition domain protein FOC85_00985 ENOG4105E2A Dehydrogenase FOC85_00995 ENOG4108IJ0 Aspartate ammonia-lyase FOC85_01000 ENOG4105HDK L-asparaginase FOC85_01005 ENOG4108IMY Transcriptional regulator FOC85_01025 ENOG4108B31 Spore germination protein FOC85_01060 ENOG41075H3 AraC family transcriptional regulator FOC85_01080 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC85_01085 ENOG4105CUB amino acid FOC85_01090 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_01110 ENOG4105CSV Glutaminase FOC85_01145 ENOG4105CGH 5'-nucleotidase FOC85_01150 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC85_01190 ENOG4108606 TspO/MBR family FOC85_01195 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC85_01210 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC85_01215 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC85_01230 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC85_01240 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC85_01245 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC85_01255 ENOG4105C19 ABC transporter FOC85_01270 ENOG4108NEV two component transcriptional regulator, LytTR family FOC85_01275 ENOG4105DSE periplasmic solute binding protein FOC85_01280 ENOG4105CC5 ABC transporter FOC85_01285 ENOG4105DIK (ABC) transporter FOC85_01310 ENOG4105D6J arsenicaL-resistance protein FOC85_01315 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_01320 ENOG41085FC arsR family transcriptional regulator FOC85_01335 ENOG4105F7F Chaperone FOC85_01370 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC85_01375 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_01385 ENOG4105IIP Membrane FOC85_01400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_01405 ENOG41062D9 Histidine kinase FOC85_01430 ENOG4105K6H D-cysteine desulfhydrase FOC85_01455 ENOG4108NNI Beta-lactamase domain-containing protein FOC85_01460 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC85_01470 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC85_01485 ENOG4105C88 aminopeptidase FOC85_01495 ENOG4105W1Y Transcriptional regulator FOC85_01500 ENOG4105JQZ Methyltransferase FOC85_01520 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC85_01535 ENOG4105BZU Histidine kinase FOC85_01550 ENOG4108U05 Transcriptional regulator FOC85_01555 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOC85_01565 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC85_01580 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC85_01595 ENOG4105CEP NADH dehydrogenase FOC85_01600 ENOG4105D4Y metalloprotease FOC85_01605 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC85_01655 ENOG4105TRI Hydrolase FOC85_01695 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC85_01720 ENOG4105C44 Serine transporter FOC85_01725 ENOG4105EJQ L-serine dehydratase FOC85_01735 ENOG4105MZU cell filamentation protein FOC85_01740 ENOG4108JPW Aminotransferase FOC85_01755 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC85_01765 ENOG4105DVH amino acid FOC85_01780 ENOG4108JQ1 Dehydrogenase FOC85_01800 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC85_01805 ENOG410874W AraC family transcriptional regulator FOC85_01820 ENOG4108IBT Inherit from COG: transposase FOC85_01835 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC85_01875 ENOG4108ISG Major Facilitator FOC85_01885 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC85_01890 ENOG4105CZM Major Facilitator FOC85_01905 ENOG4105DA5 (ABC) transporter FOC85_01910 ENOG41069JR FOC85_01920 ENOG4105RXJ FOC85_01930 ENOG4105KBX Transcriptional regulator, TetR family FOC85_01935 ENOG4107AUC FOC85_01945 ENOG4105CRW Short chain fatty acid transporter FOC85_01955 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC85_01990 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC85_02015 ENOG4108K8S endonuclease I FOC85_02020 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC85_02050 ENOG4105DSE periplasmic solute binding protein FOC85_02055 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC85_02075 ENOG4108Z66 YbaK ebsC protein FOC85_02085 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_02105 ENOG4105KVH Transcriptional regulator FOC85_02110 ENOG4108RCM Nitroreductase FOC85_02130 ENOG4108PSK reductase FOC85_02140 ENOG4105CJ1 ABC, transporter FOC85_02175 ENOG4105D7V transposase FOC85_02215 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_02220 ENOG4105DKQ ROK family FOC85_02225 ENOG4106UW1 Major Facilitator superfamily FOC85_02230 ENOG4108UW5 maltose o-acetyltransferase FOC85_02255 ENOG4105DMQ Methyltransferase FOC85_02265 ENOG4105EV4 Multidrug resistance protein mdtH FOC85_02295 ENOG4105C37 (CBS) domain FOC85_02310 ENOG4105DDN Pentapeptide repeat-containing protein FOC85_02315 ENOG4105XDF Protein of unknown function (DUF1272) FOC85_02320 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC85_02325 ENOG4105CMG Carbohydrate kinase FOC85_02330 ENOG4105C6Z Gluconate FOC85_02335 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC85_02350 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC85_02370 ENOG4105C44 Serine transporter FOC85_02405 ENOG4108TZY GntR Family Transcriptional Regulator FOC85_02410 ENOG4105D9R oxidoreductase FOC85_02445 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC85_02455 ENOG4105CHR reductase FOC85_02465 ENOG4105KNA -acetyltransferase FOC85_02475 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC85_02480 ENOG4105KVH Transcriptional regulator FOC85_02545 ENOG4105KAF membrAne FOC85_02595 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC85_02610 ENOG4107YXZ hydrolase, family 25 FOC85_02645 ENOG4105H3G oxidoreductase FOC85_02690 ENOG4105K7K Transcriptional regulator FOC85_02695 ENOG4105CIS alcohol dehydrogenase FOC85_02730 ENOG4108TN2 lmbE family FOC85_02740 ENOG4107R3E Citrate transporter FOC85_02755 ENOG4108MES Periplasmic binding protein FOC85_02760 ENOG4105EHG Permease protein FOC85_02765 ENOG4105DQ5 transport system permease protein FOC85_02770 ENOG4105NX3 Membrane FOC85_02775 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC85_02795 ENOG4107V2S Transcriptional regulator FOC85_02815 ENOG4105C98 muts2 protein FOC85_02830 ENOG4105E5K Alpha-amylase FOC85_02835 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC85_02840 ENOG4105DPN Oligoendopeptidase f FOC85_02845 ENOG4108A04 Beta-lactamase FOC85_02875 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC85_02900 ENOG41082BM Transcriptional regulator, arsr family FOC85_02905 ENOG4105CIS alcohol dehydrogenase FOC85_02940 ENOG4105C09 Bile acid FOC85_02945 ENOG4105CQB FAD linked oxidase domain protein FOC85_02965 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC85_02975 ENOG4105K64 Glycosyl transferase, family 2 FOC85_02980 ENOG4105E39 Enoyl-CoA hydratase FOC85_02990 ENOG4105KT7 mgtC SapB transporter FOC85_03005 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_03010 ENOG41073R8 VanW family FOC85_03020 ENOG4108R1P FOC85_03035 ENOG4105VEQ Cold shock protein FOC85_03075 ENOG410904N short-chain dehydrogenase reductase FOC85_03085 ENOG4106IQC argininosuccinate lyase FOC85_03100 ENOG4108IA2 Sodium pantothenate symporter FOC85_03110 ENOG4105C26 Dehydrogenase FOC85_03115 ENOG4105CHR reductase FOC85_03125 ENOG4105EWU Squalene--hopene cyclase FOC85_03135 ENOG4105FR1 rard protein FOC85_03140 ENOG410696E Membrane FOC85_03155 ENOG4105D1F ATP-binding protein FOC85_03165 ENOG4108ZAF Molybdopterin FOC85_03170 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC85_03175 ENOG4105D06 uba thif-type nad fad binding protein FOC85_03180 ENOG4105TMB Formate nitrite transporter FOC85_03190 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC85_03195 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC85_03205 ENOG4108JB9 formate dehydrogenase FOC85_03210 ENOG4105E1K spore germination protein FOC85_03275 ENOG4107QJT sodium dicarboxylate symporter FOC85_03280 ENOG4108KGH TRANSCRIPTIONal FOC85_03290 ENOG4105EMN RNA polymerase sigma factor FOC85_03310 ENOG4105CIG ABC transporter FOC85_03320 ENOG4105D9R oxidoreductase FOC85_03335 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC85_03340 ENOG4105K4P CoA-binding domain protein FOC85_03345 ENOG4105C0H protease FOC85_03350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_03360 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC85_03370 ENOG4105W8X HesB YadR YfhF-family protein FOC85_03400 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC85_03405 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC85_03415 ENOG4108JJA ABC, transporter FOC85_03420 ENOG4108I0Z Aconitate hydratase FOC85_03460 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC85_03480 ENOG4107F3J Amp-dependent synthetase and ligase FOC85_03485 ENOG4107ZYJ bioY protein FOC85_03490 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_03540 ENOG4107AYK membrAne FOC85_03550 ENOG4105BZU Histidine kinase FOC85_03555 ENOG4105FBA Phospholipase Carboxylesterase FOC85_03560 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC85_03565 ENOG4105CK7 Sodium proline symporter FOC85_03570 ENOG4105CBC glutamate synthase FOC85_03575 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC85_03580 ENOG4108VJ1 Transcriptional regulator (CarD family FOC85_03585 ENOG4108903 Formimidoylglutamase FOC85_03610 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC85_03655 ENOG4107QIV Cytochrome c biogenesis protein FOC85_03675 ENOG4105CJ1 ABC, transporter FOC85_03685 ENOG4107RSM transcriptional regulator FOC85_03695 ENOG41067MG lrgb family FOC85_03720 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC85_03735 ENOG4105BZ1 (ABC) transporter FOC85_03740 ENOG4105BZ1 (ABC) transporter FOC85_03780 ENOG4105CGH 5'-nucleotidase FOC85_03790 ENOG4108SVB resolvase FOC85_03810 ENOG4105K7K Transcriptional regulator FOC85_03815 ENOG4105C5F glutamine synthetase FOC85_03820 ENOG4105KV4 Transcriptional regulator FOC85_03825 ENOG4105CXI aluminum resistance protein FOC85_03830 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC85_03835 ENOG4105EN6 Membrane FOC85_03840 ENOG4106F1P AAA ATPase, central domain protein FOC85_03870 ENOG41069ER domain protein FOC85_03875 ENOG4105DM4 PTS System FOC85_03880 ENOG4105DE4 1-phosphofructokinase FOC85_03885 ENOG4105E98 transcriptional regulator DeoR family FOC85_03890 ENOG4107QW4 alcohol dehydrogenase FOC85_03895 ENOG4108SJC Membrane FOC85_03905 ENOG4105C85 amino acid FOC85_03925 ENOG4105TMB Formate nitrite transporter FOC85_03930 ENOG4105K70 DNA-binding protein FOC85_03935 ENOG4105C59 p-type ATPase FOC85_03940 ENOG410681U heavy metal transport detoxification protein FOC85_03945 ENOG4105VPX protein, conserved in bacteria FOC85_03965 ENOG4105NIV Esterase FOC85_03970 ENOG4105E0A ABC, transporter FOC85_03990 ENOG4105CGK Exodeoxyribonuclease III FOC85_04000 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC85_04005 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC85_04035 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_04040 ENOG4105BZU Histidine kinase FOC85_04130 ENOG4105F0V Cell wall hydrolase FOC85_04140 ENOG4105E0M Sulfatase FOC85_04145 ENOG410890F Dynamin family FOC85_04155 ENOG4107QHE Choloylglycine hydrolase FOC85_04185 ENOG4105DQU oxidoreductase, subunit beta FOC85_04190 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC85_04195 ENOG4108IGT Dipeptidase FOC85_04200 ENOG4105MCT stage V sporulation protein S FOC85_04205 ENOG4105D48 metallophosphoesterase FOC85_04225 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC85_04240 ENOG4105XZV Protein of unknown function (DUF3243) FOC85_04245 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC85_04265 ENOG4105UIB (ABC) transporter FOC85_04270 ENOG4108JQ9 ABC transporter FOC85_04275 ENOG4105DIH basic membrane FOC85_04280 ENOG4105FDP GntR family transcriptional regulator FOC85_04285 ENOG4107QZI cell division protein FtsK FOC85_04295 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC85_04305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC85_04315 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC85_04320 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC85_04325 ENOG4105E35 Dipicolinate synthase subunit A FOC85_04335 ENOG4105C1V Peptidase, M16 FOC85_04355 ENOG4105DTN riboflavin biosynthesis protein ribF FOC85_04370 ENOG4105W7A Protein of unknown function (DUF503) FOC85_04380 ENOG4105VHM ribosomal protein FOC85_04385 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC85_04390 ENOG4105CHV Transcription elongation factor NusA FOC85_04400 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC85_04405 ENOG4105EKQ RNA-directed DNA polymerase FOC85_04420 ENOG4105DZP Membrane-associated zinc metalloprotease FOC85_04430 ENOG4105KNE Phosphatidate cytidylyltransferase FOC85_04475 ENOG4108HE4 integrase family FOC85_04485 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC85_04490 ENOG4105C79 DNA protecting protein DprA FOC85_04495 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC85_04510 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC85_04535 ENOG4105VB6 UPF0109 protein FOC85_04555 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC85_04560 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC85_04575 ENOG4105CHR reductase FOC85_04580 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC85_04595 ENOG4105CB5 ATP-dependent DNA helicase recG FOC85_04600 ENOG4105DP4 dak2 domain fusion protein ylov FOC85_04605 ENOG4108ZAA Alkaline-shock protein FOC85_04620 ENOG4105FJ0 thiamine FOC85_04625 ENOG4105DJV ribulose-phosphate 3-epimerase FOC85_04630 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC85_04635 ENOG4105D9P serine threonine protein kinase FOC85_04640 ENOG4108ZF3 Phosphatase FOC85_04650 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC85_04660 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC85_04665 ENOG4105C25 Primosomal protein n' FOC85_04670 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC85_04690 ENOG4105DSJ YicC domain protein FOC85_04705 ENOG4105DC7 peptidase M24 FOC85_04795 ENOG4105C34 Pseudouridine synthase FOC85_04820 ENOG4105DBK s4 domain protein FOC85_04825 ENOG41067XK integral membrane protein FOC85_04835 ENOG4105DFA alanine racemase domain protein FOC85_04840 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC85_04845 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC85_04855 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_04865 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC85_04870 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC85_04875 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC85_04880 ENOG4105D4A Cell wall formation (By similarity) FOC85_04890 ENOG4105CNI cell division protein FtsW FOC85_04905 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC85_04910 ENOG4105CJN penicillin-binding protein FOC85_04915 ENOG4105CJN penicillin-binding protein FOC85_04920 ENOG41068DC Essential cell division protein (By similarity) FOC85_04955 ENOG4105KNH Nucleic acid-binding protein FOC85_04965 ENOG41063PX domain protein FOC85_04970 ENOG4105D78 K07001 NTE family protein FOC85_04975 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC85_04985 ENOG4106H78 methyltransferase FOC85_05005 ENOG4107TB6 phosphoglycerate mutase FOC85_05020 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC85_05070 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC85_05075 ENOG4105CNI cell division protein FtsW FOC85_05090 ENOG4108IAB Phoh family FOC85_05110 ENOG4105QA2 FOC85_05115 ENOG4105CI3 gtp-binding protein typa FOC85_05125 ENOG4105ECY inositol monophosphatase FOC85_05145 ENOG4105CXN decarboxylase FOC85_05195 ENOG4105CPP Dehydrogenase, E1 component FOC85_05210 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC85_05215 ENOG4108X4Q Hydrolase FOC85_05225 ENOG4105CN5 Metallo-Beta-Lactamase FOC85_05230 ENOG4107ZYR domain protein FOC85_05265 ENOG4108XRC Protein of unknown function (DUF458) FOC85_05275 ENOG4107IN1 Protein of unknown function (DUF1797) FOC85_05290 ENOG4105EPM Diguanylate phosphodiesterase FOC85_05295 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC85_05310 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC85_05320 ENOG4105UIN FOC85_05375 ENOG4108HGU Histidine kinase FOC85_05385 ENOG4105CHM Aminotransferase FOC85_05390 ENOG4105FKQ transcriptional regulator FOC85_05395 ENOG4105EG2 ABC transporter, permease FOC85_05405 ENOG4107FKK extracellular solute-binding protein family 1 FOC85_05415 ENOG4105CG3 alpha amylase, catalytic region FOC85_05460 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOC85_05465 ENOG4105CHU acetyl-coa acetyltransferase FOC85_05495 ENOG4105K7K Transcriptional regulator FOC85_05500 ENOG4105DTD Dehydrogenase FOC85_05520 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC85_05560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC85_05565 ENOG4105BZU Histidine kinase FOC85_05585 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC85_05600 ENOG4105CID antiterminator FOC85_05620 ENOG4105CE4 GlcNAc 6-P deacetylase FOC85_05655 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC85_05660 ENOG4105PTM secreted protein FOC85_05665 ENOG4105J7I hydrolase FOC85_05675 ENOG4105G6R Stage v sporulation protein ae FOC85_05685 ENOG4105CZ3 stage V sporulation protein ad FOC85_05690 ENOG41090VF Stage v sporulation protein ac FOC85_05710 ENOG4105C8J )-transporter FOC85_05715 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_05725 ENOG41082AN stage II sporulation protein FOC85_05730 ENOG4105DZ1 carboxypeptidase FOC85_05735 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC85_05740 ENOG4105DVE abc transporter atp-binding protein FOC85_05770 ENOG4105D7N magnesium and cobalt transport protein CorA FOC85_05795 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC85_05805 ENOG4105I3K Ferric uptake regulator, Fur family FOC85_05810 ENOG4105MZ9 stage II sporulation protein m FOC85_05830 ENOG4105CPC Aldo Keto reductase FOC85_05840 ENOG4105RHY Pfam:UPF0157 FOC85_05860 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC85_05870 ENOG4105ETE Transcriptional regulator (LacI family FOC85_05875 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC85_05895 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC85_05900 ENOG4108R6K riboflavin synthase, subunit alpha FOC85_05925 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC85_05930 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC85_05945 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC85_05955 ENOG4105DFD Na H antiporter FOC85_05960 ENOG4105CGH 5'-nucleotidase FOC85_06000 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC85_06015 ENOG4108IXY short-chain dehydrogenase reductase FOC85_06020 ENOG41069FQ Metallo-beta-lactamase superfamily FOC85_06025 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_06030 ENOG4105EJQ L-serine dehydratase FOC85_06055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC85_06065 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC85_06070 ENOG4105D9U N-acetyltransferase FOC85_06085 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC85_06090 ENOG4108QEG Membrane FOC85_06095 ENOG4105CDA abc transporter atp-binding protein FOC85_06100 ENOG4105E5Q amino acid AbC transporter FOC85_06105 ENOG4108HW3 (ABC) transporter FOC85_06115 ENOG4105G7B Protein of unknown function (DUF2992) FOC85_06120 ENOG4105E09 nadh pyrophosphatase FOC85_06130 ENOG4105C7S Dehydrogenase FOC85_06135 ENOG4105CPP Dehydrogenase, E1 component FOC85_06155 ENOG4107RDP Dehydrogenase FOC85_06165 ENOG4108JUB Transcriptional regulator FOC85_06175 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC85_06190 ENOG4107QQR Sporulation FOC85_06195 ENOG4105S1Z Stage IV sporulation protein B FOC85_06200 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC85_06210 ENOG4105DX0 Hemolysin A FOC85_06220 ENOG4105CTB Polyprenyl synthetase FOC85_06245 ENOG4108ZSR alkaline shock protein FOC85_06250 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC85_06275 ENOG410644B Stage III sporulation protein af FOC85_06285 ENOG4105KQ4 Stage iii sporulation protein ad FOC85_06290 ENOG4108CQH stage III sporulation protein AC FOC85_06295 ENOG4105KR5 Stage iii sporulation protein FOC85_06300 ENOG4105CD2 stage iii sporulation protein aa FOC85_06325 ENOG4105DC7 peptidase M24 FOC85_06340 ENOG4105CBJ Metal-dependent enzyme FOC85_06350 ENOG4107YBY Hydrolase FOC85_06365 ENOG4105K7K Transcriptional regulator FOC85_06380 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC85_06385 ENOG4105WZW rhodanese family FOC85_06405 ENOG41080TC multidrug resistance protein FOC85_06440 ENOG4105CJ1 ABC, transporter FOC85_06445 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC85_06475 ENOG4105C0D helicase FOC85_06595 ENOG4105C3R Methionine synthase FOC85_06605 ENOG4105C28 cystathionine FOC85_06610 ENOG4105C28 cystathionine FOC85_06630 ENOG4105C5X domain protein FOC85_06640 ENOG4105DKQ ROK family FOC85_06650 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC85_06665 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC85_06675 ENOG4105E2Z phosphate ABC transporter (Permease FOC85_06680 ENOG4105C8U phosphate abc transporter FOC85_06685 ENOG4105PWN phosphate abc transporter FOC85_06690 ENOG4107RF6 penicillin-binding protein FOC85_06700 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC85_06725 ENOG4105N80 Ferric uptake regulator, Fur family FOC85_06735 ENOG4105FDK ABC transporter FOC85_06740 ENOG4108JYZ YitT family FOC85_06745 ENOG41069ZM Protein of unknown function (DUF2624) FOC85_06770 ENOG4105EGD dinuclear metal center protein, YbgI family FOC85_06785 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_06790 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC85_06820 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC85_06825 ENOG4105KG3 cytidine deaminase FOC85_06830 ENOG4107YR5 Diacylglycerol kinase FOC85_06840 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC85_06845 ENOG4105C9A Phoh family FOC85_06855 ENOG41068P3 sporulation protein YqfC FOC85_06860 ENOG4105KTH gatB Yqey FOC85_06870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC85_06875 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC85_06905 ENOG4105CSA Coproporphyrinogen iii oxidase FOC85_06910 ENOG4105KVH Transcriptional regulator FOC85_06935 ENOG4105TQK DNA polymerase iii, delta' subunit FOC85_06945 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC85_06950 ENOG4108UK2 deaminase FOC85_06955 ENOG4105KQC Competence protein FOC85_06965 ENOG4105DXX methyltransferase FOC85_06975 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC85_06985 ENOG410812S Rna-binding protein FOC85_06995 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC85_07000 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC85_07015 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_07045 ENOG4108TVJ Nitroreductase FOC85_07060 ENOG4105G6Z alkaline phosphatase FOC85_07070 ENOG4108MUZ hydrolase FOC85_07105 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC85_07110 ENOG4105MIR Phenylalanine 4-monooxygenase FOC85_07120 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_07160 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC85_07165 ENOG4108V5C ABC transporter FOC85_07175 ENOG4105C0A alcohol dehydrogenase FOC85_07180 ENOG4105C28 cystathionine FOC85_07210 ENOG4107XRG penicillin-binding protein FOC85_07225 ENOG4105CFP Peptidase U32 FOC85_07230 ENOG4105XYU peptidase (U32 family) FOC85_07240 ENOG4105HHA aminodeoxychorismate lyase FOC85_07270 ENOG4105C02 permease FOC85_07285 ENOG41060CR FOC85_07290 ENOG4105C7H Helicase, RecD TraA family FOC85_07305 ENOG4105C3J Cysteine desulfurase FOC85_07315 ENOG4105D1H recombination factor protein RarA FOC85_07320 ENOG4108VCI transcription factor, rsfa family FOC85_07325 ENOG4105CUZ uba thif-type nad fad binding protein FOC85_07350 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC85_07360 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC85_07365 ENOG41076HS cation diffusion facilitator family transporter FOC85_07370 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC85_07380 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC85_07385 ENOG4108QG2 Membrane FOC85_07395 ENOG4105VIE preprotein translocase, subunit YajC FOC85_07410 ENOG41061AI Protein of unknown function (DUF2905) FOC85_07425 ENOG4108HUF Transporter FOC85_07435 ENOG4108IPJ Membrane FOC85_07440 ENOG41082BM Transcriptional regulator, arsr family FOC85_07465 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC85_07470 ENOG4108IYU L-aspartate oxidase FOC85_07485 ENOG4108RPX mosc domain containing protein FOC85_07490 ENOG4105CQC Prephenate dehydratase FOC85_07510 ENOG4105EWM Histidine kinase FOC85_07535 ENOG4105X36 (ribosomal) protein FOC85_07545 ENOG4105C03 ribonuclease FOC85_07560 ENOG4107QMS site-determining protein FOC85_07580 ENOG4105DFF Rod shape-determining protein mreb FOC85_07660 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC85_07675 ENOG41068KH stage VI sporulation protein D FOC85_07685 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC85_07710 ENOG4105K56 Transcriptional regulator FOC85_07730 ENOG4108IUQ atp-dependent protease FOC85_07760 ENOG4108QCI YvbH-like oligomerisation region FOC85_07775 ENOG4105M59 Phosphodiesterase, mj0936 family FOC85_07790 ENOG4108XJQ germination protein FOC85_07800 ENOG4108PCX Major Facilitator FOC85_07810 ENOG4105KBX Transcriptional regulator, TetR family FOC85_07825 ENOG4105PFC Transcriptional regulator FOC85_07835 ENOG4105DZC cytosine deaminase FOC85_07840 ENOG41067S9 phage shock protein C, PspC FOC85_07845 ENOG4108JCI Transcriptional regulator FOC85_07855 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC85_07860 ENOG4108Z40 Transcriptional regulator FOC85_07865 ENOG4105RHA ABC transporter, permease FOC85_07870 ENOG4108IUX (ABC) transporter FOC85_07875 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC85_07880 ENOG4105ER2 Ompa motb domain protein FOC85_07885 ENOG4105E14 MotA TolQ exbB proton channel FOC85_07890 ENOG4108VXD carboxy-peptidase FOC85_07900 ENOG4105E33 succinate dehydrogenase FOC85_07910 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC85_07925 ENOG4105K63 Thioredoxin FOC85_07930 ENOG4105C10 Electron transfer flavoprotein FOC85_07935 ENOG4105BZJ Electron transfer flavoprotein FOC85_07940 ENOG41060WC Enoyl-CoA hydratase FOC85_07945 ENOG4107Z3H Transcriptional regulator, TetR family FOC85_07950 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_07960 ENOG4105J76 Periplasmic binding protein FOC85_07965 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC85_08005 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_08020 ENOG4105DR4 Methyltransferase FOC85_08035 ENOG4105KFN sortase, SrtB family FOC85_08040 ENOG4105E0A ABC, transporter FOC85_08055 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC85_08060 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC85_08070 ENOG4105FE9 pseudouridine synthase FOC85_08080 ENOG4105DCG PHP domain protein FOC85_08130 ENOG4108RWN rrna methyltransferase FOC85_08175 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_08180 ENOG4105CW7 secretion protein, HlyD family FOC85_08185 ENOG4108JGH Tetr family transcriptional regulator FOC85_08190 ENOG4105CN9 Peptidase m42 family protein FOC85_08215 ENOG4105C22 threonyL-tRNA synthetase FOC85_08220 ENOG4108TDW sporulation protein YtxC FOC85_08245 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC85_08250 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC85_08265 ENOG4105C2M dna polymerase I FOC85_08270 ENOG4105BZU Histidine kinase FOC85_08275 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_08295 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC85_08300 ENOG4105BZN citrate synthase FOC85_08310 ENOG4108REF Sporulation integral membrane protein ytvi FOC85_08315 ENOG4105FS0 cytoplasmic membrane protein FOC85_08340 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC85_08345 ENOG4105C6K Malic enzyme FOC85_08350 ENOG4105C0B DNA polymerase III (alpha subunit) FOC85_08355 ENOG4105VV2 FOC85_08365 ENOG4105SFS phosphoesterase RecJ domain protein FOC85_08405 ENOG4105DC7 peptidase M24 FOC85_08450 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC85_08460 ENOG4105VZ8 Transcriptional regulator FOC85_08480 ENOG4107YZX Universal stress protein FOC85_08520 ENOG4108JYZ YitT family FOC85_08535 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC85_08545 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC85_08550 ENOG4105KBJ sporulation protein ytfj FOC85_08565 ENOG4105EFZ amidohydrolase FOC85_08575 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC85_08600 ENOG4106KR7 LysR family Transcriptional regulator FOC85_08610 ENOG4105U5Y Transcriptional regulator FOC85_08620 ENOG4105C28 cystathionine FOC85_08670 ENOG4105EMN RNA polymerase sigma factor FOC85_08685 ENOG4105F1V Acetoin utilization protein FOC85_08690 ENOG4105W87 Cbs domain FOC85_08695 ENOG4105DGU Histone deacetylase FOC85_08710 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_08720 ENOG4107SNB ankyrin repeat protein YahD FOC85_08725 ENOG4105EP9 oxidoreductase FOC85_08755 ENOG4105ETE Transcriptional regulator (LacI family FOC85_08775 ENOG4105C88 aminopeptidase FOC85_08820 ENOG4108VDD TRNA binding domain protein FOC85_08850 ENOG4105C8F Beta-lactamase domain protein FOC85_08865 ENOG4108V15 phosphotransferase enzyme family FOC85_08870 ENOG4108IUM Glycogen debranching enzyme FOC85_08880 ENOG4107QSE Dipeptidase FOC85_08885 ENOG4105YW5 deoR family transcriptional regulator FOC85_08900 ENOG4105CBX hi0933 family FOC85_08935 ENOG4108VJ1 Transcriptional regulator (CarD family FOC85_08940 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC85_08960 ENOG4108ZAF Molybdopterin FOC85_08965 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC85_08970 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC85_08980 ENOG4105D06 uba thif-type nad fad binding protein FOC85_08985 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC85_09005 ENOG41085GJ domain protein FOC85_09015 ENOG4105DWV Homoserine O-trans-acetylase FOC85_09025 ENOG4108B31 Spore germination protein FOC85_09060 ENOG410605W Major Facilitator FOC85_09065 ENOG4107S91 Sodium hydrogen exchanger FOC85_09070 ENOG4105NCW Trka-c domain protein FOC85_09085 ENOG4105C19 ABC transporter FOC85_09105 ENOG4105N5T Radical SAM Protein FOC85_09115 ENOG4105CIG ABC transporter FOC85_09160 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC85_09165 ENOG4108Z0R Transferase FOC85_09170 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC85_09175 ENOG4105BZF Glycosyl transferase (Group 1 FOC85_09185 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC85_09250 ENOG4107XGZ Hydrolase FOC85_09255 ENOG4105E98 transcriptional regulator DeoR family FOC85_09265 ENOG4105BZU Histidine kinase FOC85_09270 ENOG4105BZU Histidine kinase FOC85_09275 ENOG4107S9D Alpha beta hydrolase FOC85_09280 ENOG4107T7U Sulfatase FOC85_09295 ENOG4105D2X ABC transporter substrate-binding protein FOC85_09305 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC85_09320 ENOG4107XGZ Hydrolase FOC85_09365 ENOG4108V2W Carbonate dehydratase FOC85_09370 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC85_09375 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC85_09420 ENOG41087YS Phage shock protein A FOC85_09480 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FOC85_09485 ENOG4105BZU Histidine kinase FOC85_09490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_09515 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC85_09520 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC85_09530 ENOG4105D7V transposase FOC85_09550 ENOG4107ZTW SNARE associated Golgi FOC85_09560 ENOG41063TF transcriptional regulator (AraC FOC85_09575 ENOG4105C19 ABC transporter FOC85_09580 ENOG41086D8 Transcriptional regulator FOC85_09620 ENOG4105C6Z Gluconate FOC85_09645 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC85_09665 ENOG4105DTQ mandelate racemase muconate lactonizing FOC85_09675 ENOG4108IPT Naphthoate synthase FOC85_09680 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC85_09690 ENOG4105E4F Isochorismate synthase FOC85_09695 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC85_09705 ENOG4105VEQ Cold shock protein FOC85_09750 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC85_09850 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC85_09885 ENOG4105KT7 mgtC SapB transporter FOC85_09890 ENOG4107PBV potassium channel FOC85_09905 ENOG4105WG9 Conserved Protein FOC85_09915 ENOG4105CHM Aminotransferase FOC85_09920 ENOG4108ZB6 transcriptional regulator AsnC family FOC85_09925 ENOG4105C5I Dehydrogenase FOC85_09930 ENOG4108MUZ hydrolase FOC85_09940 ENOG4105C87 Aminotransferase class I and II FOC85_09955 ENOG4105Y38 Kinase-associated protein B FOC85_09965 ENOG4107R3E Citrate transporter FOC85_09985 ENOG4105KA0 thioesterase Superfamily protein FOC85_10000 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC85_10020 ENOG41069ER domain protein FOC85_10035 ENOG4105CEP NADH dehydrogenase FOC85_10065 ENOG4105EWC Purine nucleoside phosphorylase FOC85_10075 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC85_10100 ENOG4108JJA ABC, transporter FOC85_10105 ENOG4105C4B ABC transporter, permease FOC85_10110 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC85_10135 ENOG41083MR nifu domain-containing protein FOC85_10150 ENOG4108W5N phosphatidylglycerophosphatase a FOC85_10165 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC85_10170 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC85_10175 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC85_10190 ENOG4105CBT Fructose-1,6-bisphosphatase FOC85_10205 ENOG4105MMD transcriptional regulator FOC85_10210 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC85_10215 ENOG4107TXC Transcriptional regulator FOC85_10220 ENOG41090T1 Membrane FOC85_10245 ENOG4105FAA peptidase M23 FOC85_10255 ENOG4105KZD Domain of unknown function (DUF1805) FOC85_10260 ENOG4107R8B 5'-nucleotidase FOC85_10275 ENOG4105DIW FeS assembly protein SUFB FOC85_10280 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC85_10285 ENOG4105C9B Cysteine desulfurase FOC85_10290 ENOG4105JRK feS assembly protein SufD FOC85_10295 ENOG4105C3K feS assembly ATPase SufC FOC85_10300 ENOG4105D01 (LipO)protein FOC85_10305 ENOG4105D01 (LipO)protein FOC85_10310 ENOG4108UMI ABC transporter, permease FOC85_10340 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC85_10385 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC85_10410 ENOG4108IMY Transcriptional regulator FOC85_10420 ENOG4108W8B Beta-lactamase domain protein FOC85_10430 ENOG4108IUW ABC transporter FOC85_10455 ENOG4105C1G acyl-Coa dehydrogenase FOC85_10460 ENOG4105CHU acetyl-coa acetyltransferase FOC85_10475 ENOG4105DZ1 carboxypeptidase FOC85_10495 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC85_10515 ENOG4108SUT Major Facilitator Superfamily FOC85_10520 ENOG4107R7I amino acid FOC85_10535 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC85_10545 ENOG4107AYK membrAne FOC85_10580 ENOG4107ZTW SNARE associated Golgi FOC85_10590 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC85_10595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_10600 ENOG4105BZU Histidine kinase FOC85_10620 ENOG4105C8Q Methyl-accepting chemotaxis FOC85_10625 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC85_10630 ENOG4105VG1 fes assembly suf system protein FOC85_10635 ENOG4105D4Y metalloprotease FOC85_10655 ENOG4107S91 Sodium hydrogen exchanger FOC85_10660 ENOG4105NCW Trka-c domain protein FOC85_10670 ENOG4108RMU ferritin dps family protein FOC85_10685 ENOG4108URH decarboxylase FOC85_10705 ENOG4105D9N nucleoside FOC85_10710 ENOG4105D9N nucleoside FOC85_10725 ENOG4108RYK Nad-dependent epimerase dehydratase FOC85_10740 ENOG4105CV8 reductase FOC85_10745 ENOG4105F27 Major Facilitator FOC85_10750 ENOG4105KVH Transcriptional regulator FOC85_10765 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC85_10790 ENOG4105WMR Protein CrcB homolog FOC85_10815 ENOG4105C5H ABC transporter FOC85_10820 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC85_10840 ENOG4108IPW abc transporter atp-binding protein FOC85_10845 ENOG4105CM4 permease protein FOC85_10860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_10875 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC85_10885 ENOG4105XZU Preprotein translocase, subunit SecG FOC85_10890 ENOG41067MG lrgb family FOC85_10940 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_10960 ENOG41090VF Stage v sporulation protein ac FOC85_10965 ENOG4105CZ3 stage V sporulation protein ad FOC85_10980 ENOG4105H67 Protein of unknown function (DUF421) FOC85_10990 ENOG4105KRI phosphocarrier protein (HPr FOC85_11000 ENOG4105CHW UPF0052 protein FOC85_11010 ENOG4108Z4K mutator MutT protein FOC85_11020 ENOG4105C3M thioredoxin reductase FOC85_11030 ENOG4108S4C acetyltransferase FOC85_11050 ENOG41086DT Membrane protein of unknown function FOC85_11100 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC85_11105 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC85_11120 ENOG4107TXC Transcriptional regulator FOC85_11145 ENOG4105HMI Membrane FOC85_11150 ENOG4105DUM transcriptional regulator, lysR family FOC85_11160 ENOG4108WS4 fmn reductase FOC85_11165 ENOG4105C5H ABC transporter FOC85_11175 ENOG4105BZ1 (ABC) transporter FOC85_11185 ENOG4105CN1 protease FOC85_11190 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC85_11195 ENOG4105CAK Cell division ATP-binding protein ftsE FOC85_11215 ENOG4105MS2 ribosomal subunit Interface protein FOC85_11220 ENOG4105VEQ Cold shock protein FOC85_11225 ENOG41081UC Inherit from COG: Competence protein FOC85_11240 ENOG4105KVH Transcriptional regulator FOC85_11250 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC85_11255 ENOG4108KGH TRANSCRIPTIONal FOC85_11260 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC85_11265 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC85_11270 ENOG4105ESV Glycosyl transferase, family 4 FOC85_11280 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC85_11300 ENOG4105F8D glycoside hydrolase family 4 FOC85_11305 ENOG4105VCP PTS System FOC85_11310 ENOG4105CK1 PTS System FOC85_11320 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC85_11340 ENOG4105VCP PTS System FOC85_11350 ENOG4105VZJ PTS System FOC85_11365 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC85_11385 ENOG4105ECB domain protein FOC85_11390 ENOG4107RSM transcriptional regulator FOC85_11425 ENOG4105DAA L-lactate FOC85_11430 ENOG4105D7V transposase FOC85_11440 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC85_11450 ENOG4105E0M Sulfatase FOC85_11475 ENOG4107R8N Glycosyl transferase, family 2 FOC85_11480 ENOG4105C94 Transporter FOC85_11485 ENOG41069ER domain protein FOC85_11510 ENOG4105KBK Zinc finger, swim domain protein FOC85_11515 ENOG4105C0D helicase FOC85_11545 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_11560 ENOG4107RBB ABC transporter, permease FOC85_11565 ENOG4105C19 ABC transporter FOC85_11585 ENOG4105CXY transporter FOC85_11605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_11610 ENOG4105DG6 mannose-6-phosphate isomerase FOC85_11615 ENOG4105DM4 PTS System FOC85_11625 ENOG4105CMR udp-glucose 4-epimerase FOC85_11635 ENOG4108KGH TRANSCRIPTIONal FOC85_11640 ENOG4105DG6 mannose-6-phosphate isomerase FOC85_11645 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOC85_11650 ENOG4105CPK Glycosyl transferase (Group 1 FOC85_11655 ENOG4108TJN glycosyl transferase group 1 FOC85_11660 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC85_11680 ENOG4105D3Q Sugar transferase FOC85_11685 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC85_11690 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC85_11695 ENOG4107YJ4 chain length determinant protein FOC85_11700 ENOG4105HTX biosynthesis protein FOC85_11705 ENOG4107YJ4 chain length determinant protein FOC85_11720 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC85_11730 ENOG4105FRN stage II sporulation protein FOC85_11745 ENOG4105DY9 regulatoR FOC85_11765 ENOG4106778 Protein of unknown function (DUF1146) FOC85_11770 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC85_11775 ENOG4105C8S subunit m FOC85_11780 ENOG4105D65 subunit l FOC85_11810 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC85_11825 ENOG4105BZU Histidine kinase FOC85_11875 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC85_11880 ENOG41062M3 atp synthase FOC85_11910 ENOG4108YZG isomerase FOC85_11925 ENOG4108VGI doxx family FOC85_11930 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC85_11945 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC85_11955 ENOG4108ZXQ stage ii sporulation protein r FOC85_11960 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC85_11980 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC85_11985 ENOG4105CBT Fructose-1,6-bisphosphatase FOC85_12025 ENOG4105C1G acyl-Coa dehydrogenase FOC85_12030 ENOG4105C1G acyl-Coa dehydrogenase FOC85_12035 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC85_12045 ENOG4105DF6 Fe-S oxidoreductase FOC85_12060 ENOG4105BZU Histidine kinase FOC85_12085 ENOG4105BZU Histidine kinase FOC85_12090 ENOG4105KCT ABC transporter FOC85_12095 ENOG4108M15 ABC transporter FOC85_12100 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC85_12110 ENOG4105IIU Aminopeptidase FOC85_12130 ENOG4105EMN RNA polymerase sigma factor FOC85_12140 ENOG410684U Domain of unknown function (DUF1934) FOC85_12160 ENOG4105CYW agmatinase FOC85_12170 ENOG4105DXB Major Facilitator superfamily FOC85_12175 ENOG4107SWG transcriptional regulator MERR family FOC85_12180 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC85_12185 ENOG4105BZ4 penicillin-binding protein FOC85_12190 ENOG4108XFG YwhD family FOC85_12195 ENOG4108Z4T Peptidase M50 FOC85_12200 ENOG41069HH 4-oxalocrotonate tautomerase FOC85_12205 ENOG4105DCI Phosphohydrolase FOC85_12210 ENOG4108MES Periplasmic binding protein FOC85_12215 ENOG4105E0A ABC, transporter FOC85_12220 ENOG4105EHG Permease protein FOC85_12225 ENOG4105DQ5 transport system permease protein FOC85_12235 ENOG4108VCI transcription factor, rsfa family FOC85_12250 ENOG4108IJ2 phosphate acetyltransferase FOC85_12265 ENOG4108VKI Cell wall hydrolase FOC85_12285 ENOG4107SVH Potassium channel protein FOC85_12295 ENOG410667J hydrolase FOC85_12300 ENOG4105VCH membrane FOC85_12310 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC85_12315 ENOG4105CJ1 ABC, transporter FOC85_12320 ENOG41090WU lipolytic protein G-D-S-L family FOC85_12335 ENOG4105D6E homoserine dehydrogenase FOC85_12355 ENOG4108Y4K DNA-binding transcriptional activator FOC85_12365 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_12370 ENOG4105BZU Histidine kinase FOC85_12375 ENOG4105DWF phosphomethylpyrimidine kinase FOC85_12380 ENOG4105BZU Histidine kinase FOC85_12385 ENOG4105VCD cytoplasmic protein FOC85_12390 ENOG4105D22 carbon starvation protein FOC85_12395 ENOG4105DY9 regulatoR FOC85_12400 ENOG41079KZ Major Facilitator Superfamily FOC85_12420 ENOG4105EN6 Membrane FOC85_12425 ENOG4106YBV Methyl-accepting chemotaxis FOC85_12435 ENOG4108S4H thioesterase Superfamily protein FOC85_12445 ENOG4105JEU Glycosyl transferase, family 2 FOC85_12450 ENOG4105C5H ABC transporter FOC85_12470 ENOG4105CKK Glycosyl transferase, family 2 FOC85_12475 ENOG41067SE Tetr family transcriptional regulator FOC85_12485 ENOG4105E0X reductase FOC85_12490 ENOG4106F5Q Membrane FOC85_12505 ENOG4105DY9 regulatoR FOC85_12510 ENOG4108HRK Histidine kinase FOC85_12515 ENOG4107RGD Major Facilitator superfamily FOC85_12530 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC85_12540 ENOG4105IW1 AmiS UreI transporter FOC85_12550 ENOG4105CMR udp-glucose 4-epimerase FOC85_12555 ENOG4108UT2 hemolysin iii FOC85_12565 ENOG4105C1J atp-dependent rna helicase FOC85_12580 ENOG4105DPN Oligoendopeptidase f FOC85_12600 ENOG4105C0H protease FOC85_12605 ENOG4105Q2H domain protein FOC85_12620 ENOG4105BZU Histidine kinase FOC85_12625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_12655 ENOG4105CDU Replicative dna helicase FOC85_12665 ENOG4105BZR domain protein FOC85_12670 ENOG4108XMW Membrane FOC85_12680 ENOG4108UUM single-stranded DNA-binding protein FOC85_12690 ENOG4105C3G gtp-binding protein FOC85_12695 ENOG4105VDK protein, conserved in bacteria FOC85_12700 ENOG4105D8X mechanosensitive ion channel FOC85_12705 ENOG4108ZDA Sporulation protein YyaC FOC85_12710 ENOG4105FA0 parb-like partition protein FOC85_12715 ENOG4107QJE Chromosome Partitioning Protein FOC85_12745 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC85_12765 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC85_12770 ENOG410848D S4 domain protein YaaA FOC85_12785 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC85_12820 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC85_12855 ENOG4105ZMH deoxynucleoside kinase FOC85_12865 ENOG4105GTG Isochorismatase FOC85_12870 ENOG4108Z6B deaminase FOC85_12880 ENOG4105C6E dna polymerase iii FOC85_12900 ENOG41067KS pro-sigma K processing FOC85_12935 ENOG4105CXN decarboxylase FOC85_12945 ENOG4105FA2 dna polymerase iii FOC85_12950 ENOG4105MA4 psp1 domain protein FOC85_12960 ENOG41060K3 Methyltransferase FOC85_12970 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC85_12975 ENOG4105KRN Transcriptional regulator, abrb family FOC85_12985 ENOG4105F8V Hydrolase, tatD family FOC85_12990 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC85_13000 ENOG4105XFA sporulation peptidase YabG FOC85_13005 ENOG4105W42 Veg protein FOC85_13020 ENOG4105DFT pur operon repressor FOC85_13025 ENOG4105KME endoribonuclease L-psp FOC85_13055 ENOG4108JA2 transcriptioN-repair coupling factor FOC85_13060 ENOG4108M14 stage v sporulation protein t FOC85_13070 ENOG4108IY2 MazG family FOC85_13075 ENOG41082I2 s4 domain protein FOC85_13080 ENOG4105VYY sporulation protein yabp FOC85_13095 ENOG41060GV RNA binding s1 domain protein FOC85_13120 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC85_13125 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC85_13140 ENOG4105C6T cysteine synthase FOC85_13145 ENOG4105CRQ synthase (Component I) FOC85_13150 ENOG4105DDQ anthranilate synthase FOC85_13155 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC85_13160 ENOG4105EEI dihydropteroate synthase FOC85_13165 ENOG4105KRF dihydroneopterin aldolase FOC85_13170 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC85_13180 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC85_13270 ENOG4108Z0C Uvrb UvrC protein FOC85_13285 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC85_13295 ENOG4105CTP PilT protein domain protein FOC85_13315 ENOG4105D7W serine acetyltransferase FOC85_13330 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC85_13335 ENOG4105M0M Tetracycline resistance protein FOC85_13340 ENOG4105QIV RNA polymerase FOC85_13355 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC85_13380 ENOG4107Y49 methyltransferase FOC85_13395 ENOG4105XPM ribosomal protein FOC85_13525 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC85_13535 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC85_13580 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC85_13610 ENOG4105D1F ATP-binding protein FOC85_13625 ENOG4108NMV polysaccharide deacetylase FOC85_13705 ENOG4105C8B TIGR00159 family FOC85_13710 ENOG4107U5W ybbr family FOC85_13745 ENOG4105CMG Carbohydrate kinase FOC85_13755 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC85_13760 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC85_13800 ENOG4108PSK reductase FOC85_13805 ENOG4108UMI ABC transporter, permease FOC85_13810 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC85_13815 ENOG4105D01 (LipO)protein FOC85_13830 ENOG4105IQ5 FAD linked oxidase domain protein FOC85_13845 ENOG4105C2C drug resistance transporter, Bcr CflA FOC85_13860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC85_13865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC85_13870 ENOG4105C3U ABC transporter FOC85_13875 ENOG4108JQ7 (ABC) transporter FOC85_13900 ENOG4105U5Y Transcriptional regulator FOC85_13910 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC85_13915 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC85_13925 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_13930 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC85_13940 ENOG4105E0C molybdate abc transporter FOC85_13945 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC85_13950 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC85_13980 ENOG4105F6E Acyl-transferase FOC85_14000 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC85_14010 ENOG4108RE7 deoxyribonuclease FOC85_14020 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC85_14045 ENOG4105C5H ABC transporter FOC85_14060 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC85_14070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC85_14075 ENOG4105C3U ABC transporter FOC85_14080 ENOG4108JQ7 (ABC) transporter FOC85_14085 ENOG410667J hydrolase FOC85_14115 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC85_14120 ENOG4105ERH Fumarylacetoacetate hydrolase FOC85_14130 ENOG4105CUB amino acid FOC85_14135 ENOG4108SC4 )-transporter FOC85_14140 ENOG4105CPF Cell wall formation (By similarity) FOC85_14145 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC85_14160 ENOG4107ZXI Rhomboid family FOC85_14170 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC85_14175 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC85_14185 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC85_14285 ENOG4105K8N protein family UPF0079, ATPase FOC85_14290 ENOG41072GX Peptidase M22 Glycoprotease FOC85_14295 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC85_14305 ENOG4105C5H ABC transporter FOC85_14320 ENOG4108TYN CAAX amino terminal protease family protein FOC85_14335 ENOG4107EV6 Inherit from COG: YD repeat protein FOC85_14355 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC85_14395 ENOG4105C7N Xanthine uracil vitamin C permease FOC85_14405 ENOG4105BZU Histidine kinase FOC85_14430 ENOG4107ZXU DSBA oxidoreductase FOC85_14505 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_14525 ENOG4105SX7 Transporter FOC85_14550 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC85_14555 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC85_14560 ENOG4105C83 adenylosuccinate lyase FOC85_14570 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC85_14595 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC85_14605 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC85_14630 ENOG4105C4R Atp-dependent dna helicase FOC85_14660 ENOG4108W2Y isochorismatase FOC85_14665 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC85_14670 ENOG4108UMI ABC transporter, permease FOC85_14675 ENOG4105D01 (LipO)protein FOC85_14705 ENOG410834F Transcriptional regulator FOC85_14710 ENOG4107I77 yiaA/B two helix domain FOC85_14730 ENOG4105CBD Diacylglycerol kinase FOC85_14735 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC85_14740 ENOG4108JPW Aminotransferase FOC85_14750 ENOG4105C26 Dehydrogenase FOC85_14755 ENOG4105KPY Small multidrug resistance protein FOC85_14775 ENOG4105D9N nucleoside FOC85_14780 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC85_14790 ENOG4105BZU Histidine kinase FOC85_14795 ENOG4108W15 Protein of unknown function (DUF1456) FOC85_14810 ENOG4105DTQ mandelate racemase muconate lactonizing FOC85_14820 ENOG4105DFD Na H antiporter FOC85_14840 ENOG4105D3R alkyl hydroperoxide reductase FOC85_14860 ENOG4105EHG Permease protein FOC85_14865 ENOG4105DQ5 transport system permease protein FOC85_14870 ENOG4108V5C ABC transporter FOC85_14890 ENOG4106UIA FOC85_14895 ENOG4106UIA FOC85_14915 ENOG4105BZU Histidine kinase FOC85_14935 ENOG410756H nucleotidyltransferase FOC85_14940 ENOG4105D2S major facilitator superfamily FOC85_14960 ENOG4105EAB amino acid AbC transporter FOC85_14970 ENOG4105C8Q Methyl-accepting chemotaxis FOC85_14985 ENOG4105DBV ornithine carbamoyltransferase FOC85_14995 ENOG4105C5B carbamate kinase FOC85_15020 ENOG4105CI1 PTS System FOC85_15050 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC85_15065 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC85_15110 ENOG41062JF Transcriptional regulator FOC85_15130 ENOG4105DEU major facilitator superfamily FOC85_15160 ENOG4108N0M stress protein FOC85_15165 ENOG4106FN3 tellurium resistance protein FOC85_15170 ENOG4106FN3 tellurium resistance protein FOC85_15175 ENOG4107TS3 membrane protein, TerC FOC85_15180 ENOG4108TTB tellurium resistance protein FOC85_15200 ENOG4105KJF protein tyrosine phosphatase FOC85_15210 ENOG4107U9T Pfam:Ribonuclease_BN FOC85_15215 ENOG4105C59 p-type ATPase FOC85_15220 ENOG4108IPJ Membrane FOC85_15240 ENOG4107ZTW SNARE associated Golgi FOC85_15255 ENOG410606W general stress protein FOC85_15260 ENOG4105UPD Calcium Proton FOC85_15310 ENOG4108JUB Transcriptional regulator FOC85_15320 ENOG4108IQI permease FOC85_15360 ENOG4108A04 Beta-lactamase FOC85_15375 ENOG4105CKK Glycosyl transferase, family 2 FOC85_15380 ENOG4107QQG Dehydrogenase FOC85_15385 ENOG4105C3I Nad-dependent epimerase dehydratase FOC85_15405 ENOG4105F1A Pyruvate formate-lyase FOC85_15425 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC85_15430 ENOG4105ECP epimerase FOC85_15460 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC85_15465 ENOG4105CEN a g-specific adenine glycosylase FOC85_15470 ENOG4106BXE FOC85_15490 ENOG4105BZ1 (ABC) transporter FOC85_15495 ENOG4107NBY Membrane FOC85_15500 ENOG4105CBC glutamate synthase FOC85_15510 ENOG4108IUW ABC transporter FOC85_15530 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC85_15535 ENOG4105G5W regulator Fur family FOC85_15670 ENOG4105BZ1 (ABC) transporter FOC85_15685 ENOG4108JQC penicillin-binding protein 1A FOC85_15690 ENOG4107ZQN disulfide bond FOC85_15705 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC85_15715 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC85_15725 ENOG4105CYN Serine protein kinase FOC85_15745 ENOG4105C94 Transporter FOC85_15760 ENOG4105DZ6 Band 7 protein FOC85_15770 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC85_15775 ENOG4108V9W transcriptional regulatory protein FOC85_15780 ENOG4105D4T Citrate transporter FOC85_15800 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC85_15805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC85_15810 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC85_15815 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC85_15820 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC85_15825 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC85_15830 ENOG4108STX response regulator FOC85_15835 ENOG4105US7 Histidine kinase FOC85_15860 ENOG4108MRH transcriptional regulatory protein FOC85_15870 ENOG4105C6K Malic enzyme FOC85_15880 ENOG4108UZ3 Transporter FOC85_15885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC85_15895 ENOG4105BZU Histidine kinase FOC85_15900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_15905 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC85_15910 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC85_15915 ENOG4108JB9 formate dehydrogenase FOC85_15935 ENOG4105CUB amino acid FOC85_15945 ENOG4105C59 p-type ATPase FOC85_15950 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC85_15985 ENOG41073R8 VanW family FOC85_15990 ENOG4108KGH TRANSCRIPTIONal FOC85_15995 ENOG4105D9N nucleoside FOC85_16000 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC85_16005 ENOG4105C37 (CBS) domain FOC85_16010 ENOG4108IJ0 Aspartate ammonia-lyase FOC85_16015 ENOG4105DAA L-lactate FOC85_16030 ENOG4105DUX Transporter FOC85_16035 ENOG4108MES Periplasmic binding protein FOC85_16040 ENOG4105DQ5 transport system permease protein FOC85_16045 ENOG4108IHU transport system permease protein FOC85_16050 ENOG4105E0A ABC, transporter FOC85_16055 ENOG4105DMQ Methyltransferase FOC85_16065 ENOG4105EXW epimerase dehydratase FOC85_16075 ENOG4107T89 von Willebrand factor, type A FOC85_16080 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC85_16085 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC85_16095 ENOG4105BZU Histidine kinase FOC85_16100 ENOG4105D5Q Arginine ornithine antiporter FOC85_16105 ENOG4107414 GntR family transcriptional regulator FOC85_16110 ENOG4105C5Y PTS System FOC85_16115 ENOG4105CG3 alpha amylase, catalytic region FOC85_16130 ENOG4105E1K spore germination protein FOC85_16135 ENOG4108XG2 Histidine kinase FOC85_16140 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_16145 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC85_16160 ENOG4105CRN Aminoglycoside phosphotransferase FOC85_16165 ENOG4105BZG amino acid carrier protein FOC85_16170 ENOG4105CDA abc transporter atp-binding protein FOC85_16175 ENOG4105CT1 (ABC) transporter FOC85_16180 ENOG4105EAD ABC transporter FOC85_16185 ENOG4105DRP amino acid AbC transporter FOC85_16190 ENOG4108IQI permease FOC85_16215 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC85_16220 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC85_16225 ENOG4105BZU Histidine kinase FOC85_16230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_16240 ENOG4105CHH sulfate transporter FOC85_16245 ENOG41068KF Universal stress protein FOC85_16255 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC85_16265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC85_16270 ENOG4108JQ7 (ABC) transporter FOC85_16280 ENOG4105CXY transporter FOC85_16285 ENOG41067TZ transcriptional regulator, MarR family FOC85_16290 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_16295 ENOG4105ETE Transcriptional regulator (LacI family FOC85_16300 ENOG4108RVA ribokinase FOC85_16315 ENOG4105CNN ABC, transporter FOC85_16320 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC85_16385 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC85_16390 ENOG41069ER domain protein FOC85_16395 ENOG4105VZ8 Transcriptional regulator FOC85_16400 ENOG4107D63 FOC85_16410 ENOG4105DUX Transporter FOC85_16430 ENOG4105C85 amino acid FOC85_16435 ENOG4105C7N Xanthine uracil vitamin C permease FOC85_16450 ENOG4105MA6 gCN5-related N-acetyltransferase FOC85_16475 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC85_16480 ENOG4105E2S oxidase) subunit II FOC85_16495 ENOG4106CAD Protein of unknown function (DUF3311) FOC85_16500 ENOG4105E1V na solute symporter FOC85_16515 ENOG4108NHD germination protein FOC85_16520 ENOG4105CE1 Ferrous iron transport protein b FOC85_16525 ENOG4105CE1 Ferrous iron transport protein b FOC85_16530 ENOG4105CE1 Ferrous iron transport protein b FOC85_16535 ENOG4105CVA phosphate FOC85_16540 ENOG4105C8U phosphate abc transporter FOC85_16545 ENOG4105E2Z phosphate ABC transporter (Permease FOC85_16675 ENOG41080XQ Signal transduction protein with cbs domains FOC85_16695 ENOG4105ETU transcriptional activator (TenA FOC85_16705 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC85_16715 ENOG4108VEU Thiamine monophosphate synthase FOC85_16720 ENOG41080HI glycine oxidase FOC85_16735 ENOG4105D06 uba thif-type nad fad binding protein FOC85_16740 ENOG4105DWF phosphomethylpyrimidine kinase FOC85_16790 ENOG4108INS Transcriptional regulator FOC85_16815 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC85_16825 ENOG4105C7N Xanthine uracil vitamin C permease FOC85_16835 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC85_16855 ENOG4105C5Y PTS System FOC85_16890 ENOG4108B31 Spore germination protein FOC85_16910 ENOG4107Y03 Nitroreductase FOC85_16915 ENOG4105ED1 spovr family FOC85_16920 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC85_16925 ENOG4105XTG Pfam:DUF156 FOC85_16930 ENOG4105VFE sira family FOC85_16935 ENOG4107TPS domain protein FOC85_16940 ENOG4105VFE sira family FOC85_16945 ENOG41085GJ domain protein FOC85_16955 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC85_16960 ENOG41087NI Sulfite exporter TauE/SafE FOC85_16970 ENOG4108KGH TRANSCRIPTIONal FOC85_16995 ENOG4105EMD TRANSCRIPTIONal FOC85_17000 ENOG4105VCP PTS System FOC85_17005 ENOG4105VZJ PTS System FOC85_17025 ENOG41069ER domain protein FOC85_17030 ENOG4107RBB ABC transporter, permease FOC85_17035 ENOG4105C19 ABC transporter FOC85_17070 ENOG4105WEF catalase FOC85_17105 ENOG4107T5V SNARE associated Golgi FOC85_17140 ENOG4105CUB amino acid FOC85_17145 ENOG4107RWR Sodium hydrogen exchanger FOC85_17155 ENOG4106KNT transcriptional regulator FOC85_17200 ENOG4108YXU transcriptional regulator AsnC family FOC85_17215 ENOG4105KPY Small multidrug resistance protein FOC85_17230 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC85_17235 ENOG4105E5W Transporter FOC85_17245 ENOG4107RKG DJ-1/PfpI family FOC85_17250 ENOG4105CH6 catalase FOC85_17260 ENOG4105D5Q Arginine ornithine antiporter FOC85_17265 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC85_17275 ENOG4105C26 Dehydrogenase FOC85_17280 ENOG4105BZ1 (ABC) transporter FOC85_17285 ENOG4105BZ1 (ABC) transporter FOC85_17295 ENOG4105DRP amino acid AbC transporter FOC85_17300 ENOG4105CDA abc transporter atp-binding protein FOC85_17315 ENOG410839P FOC85_17350 ENOG4107FQX Alpha-acetolactate decarboxylase FOC85_17365 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC85_17370 ENOG4105D4P Coproporphyrinogen iii oxidase FOC85_17385 ENOG4105CHH sulfate transporter FOC85_17425 ENOG4106AKK s-layer domain-containing protein FOC85_17430 ENOG4106AKK s-layer domain-containing protein FOC85_17440 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC85_17450 ENOG4105CGU Enoyl-CoA hydratase FOC85_17470 ENOG4105DER m42 family FOC85_17490 ENOG4105CTU Proline racemase FOC85_17515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC85_17525 ENOG4108JQ7 (ABC) transporter FOC85_17570 ENOG4105CSH Transporter FOC85_17580 ENOG4108MRH transcriptional regulatory protein FOC85_17640 ENOG4105CDU Replicative dna helicase FOC85_17660 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_17720 ENOG4107P5I polyketide synthase FOC85_17725 ENOG4108IG5 Transcriptional regulator FOC85_17740 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC85_17770 ENOG4105CMT Dihydroxyacetone kinase FOC85_17780 ENOG4105CMT Dihydroxyacetone kinase FOC85_17785 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC85_17790 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC85_17805 ENOG410780I phosphoprotein phosphatase activity FOC85_17815 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC85_17880 ENOG4105WN5 stage II sporulation protein FOC85_17890 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_17900 ENOG4108MJI response regulator FOC85_17905 ENOG4105BZU Histidine kinase FOC85_17910 ENOG4105BZU Histidine kinase FOC85_17950 ENOG4105ENE Histidine kinase FOC85_17955 ENOG4108VB1 regulatoR FOC85_17985 ENOG4107VRP DNA repair exonuclease FOC85_17990 ENOG4106D4I domain protein FOC85_18040 ENOG4108MUZ hydrolase FOC85_18060 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC85_18075 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC85_18095 ENOG4105EMN RNA polymerase sigma factor FOC85_18120 ENOG4105C57 major facilitator superfamily FOC85_18125 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_18135 ENOG4105EEM helicase FOC85_18140 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC85_18165 ENOG4105K59 histidine triad (HIT) protein FOC85_18200 ENOG410905X membrane-flanked domain protein FOC85_18205 ENOG4105CKV Membrane FOC85_18225 ENOG41060BG Tetr family transcriptional regulator FOC85_18245 ENOG410905X membrane-flanked domain protein FOC85_18250 ENOG4105CKV Membrane FOC85_18255 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC85_18260 ENOG4105BZ4 penicillin-binding protein FOC85_18275 ENOG4105C1Q protoporphyrinogen oxidase FOC85_18305 ENOG4105NA0 Transcriptional regulator FOC85_18320 ENOG4105ECB domain protein FOC85_18325 ENOG4105ECB domain protein FOC85_18355 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FOC85_18365 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC85_18375 ENOG4106AXD FOC85_18380 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC85_18385 ENOG4105DF9 Lipoate-protein, ligase FOC85_18395 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_18460 ENOG4105ENX hydrolase FOC85_18465 ENOG4107RN3 metallophosphoesterase FOC85_18475 ENOG4107TVP HD domain protein FOC85_18485 ENOG4108AEY RNA polymerase sigma factor FOC85_18490 ENOG41086D8 Transcriptional regulator FOC85_18500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_18520 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC85_18545 ENOG4107QP3 malate synthase g FOC85_18575 ENOG4105XVF Competence transcription factor FOC85_18640 ENOG4105ERH Fumarylacetoacetate hydrolase FOC85_18665 ENOG4105CAQ asparagine synthetase FOC85_18670 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC85_18675 ENOG4105CH6 catalase FOC85_18680 ENOG4105BZU Histidine kinase FOC85_18700 ENOG4105QNR S1 RNA binding domain protein FOC85_18710 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC85_18720 ENOG4107AYK membrAne FOC85_18725 ENOG41073B9 FOC85_18735 ENOG4108KP7 hydrolase FOC85_18745 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC85_18770 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC85_18775 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC85_18790 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC85_18805 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC85_18810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC85_18820 ENOG4108JQ7 (ABC) transporter FOC85_18825 ENOG4105UQX Mate efflux family protein FOC85_18845 ENOG4108ZCF integral membrane protein FOC85_18855 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC85_18865 ENOG4105DPN Oligoendopeptidase f FOC85_18880 ENOG4108Z18 K06886 hemoglobin FOC85_18885 ENOG4105MIX Adenylate cyclase FOC85_18905 ENOG4105EMS pseudouridine synthase FOC85_18925 ENOG4105K64 Glycosyl transferase, family 2 FOC85_18945 ENOG4107TVC Glycosyl transferase, family 2 FOC85_18965 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC85_18970 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC85_18980 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC85_19055 ENOG4105CK7 Sodium proline symporter FOC85_19065 ENOG4105DDQ anthranilate synthase FOC85_19160 ENOG4105C7S Dehydrogenase FOC85_19170 ENOG4105VZ8 Transcriptional regulator FOC85_19230 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC85_19245 ENOG4108IUX (ABC) transporter FOC85_19250 ENOG4105RHA ABC transporter, permease FOC85_19295 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC85_19310 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC85_19320 ENOG4105DZ1 carboxypeptidase FOC85_19325 ENOG4105VFR signal peptidase FOC85_19360 ENOG4105C26 Dehydrogenase FOC85_19370 ENOG4105F38 ABC transporter, permease FOC85_19375 ENOG4105D38 putrescine abc transporter FOC85_19380 ENOG4107RUE extracellular solute-binding protein family 1 FOC85_19390 ENOG4105EYF MMPL domain protein FOC85_19400 ENOG4108YBP pseudouridine synthase FOC85_19410 ENOG4105K4I Scp-like extracellular FOC85_19415 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC85_19420 ENOG4105CQB FAD linked oxidase domain protein FOC85_19435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_19440 ENOG4105BZU Histidine kinase FOC85_19445 ENOG4105JXH GntR family transcriptional regulator FOC85_19465 ENOG4106A3R peptidase FOC85_19475 ENOG4108QTI )-transporter FOC85_19480 ENOG4107TS3 membrane protein, TerC FOC85_19485 ENOG4105CZN Potassium uptake protein FOC85_19490 ENOG410681C small acid-soluble spore protein FOC85_19495 ENOG4108Z7G MaoC domain protein dehydratase FOC85_19515 ENOG4105CHR reductase FOC85_19525 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC85_19545 ENOG4105C4Y ABC transporter FOC85_19550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC85_19555 ENOG4107RCV ABC transporter, permease FOC85_19575 ENOG4105E98 transcriptional regulator DeoR family FOC85_19585 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC85_19595 ENOG4105PXI polysaccharide deacetylase FOC85_19605 ENOG4105BZU Histidine kinase FOC85_19610 ENOG41090MY MarR family Transcriptional regulator FOC85_19620 ENOG4106DF1 FOC85_19625 ENOG4105BZU Histidine kinase FOC85_19635 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC85_19640 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC85_19680 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC85_19685 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC85_19690 ENOG41079K6 HNH endonuclease FOC85_19700 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC85_19705 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC85_19710 ENOG4105CZV ABC transporter FOC85_19720 ENOG4105CJ1 ABC, transporter FOC85_19760 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC85_19765 ENOG4105EA8 2-Nitropropane dioxygenase FOC85_19770 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC85_19780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC85_19805 ENOG4105NQC Flavodoxin FOC85_19840 ENOG4107QMU Mate efflux family protein FOC85_19845 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC85_19875 ENOG4105CZN Potassium uptake protein FOC85_19880 ENOG41063Y9 FOC85_19885 ENOG4105KBJ sporulation protein ytfj FOC85_19910 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC85_19915 ENOG4105C7K acetolactate synthase FOC85_19920 ENOG4108ZP8 Acetolactate synthase small subunit FOC85_19995 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC85_20005 ENOG4105C5I Dehydrogenase FOC85_20010 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC85_20015 ENOG4105E0M Sulfatase FOC85_20025 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC85_20045 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC85_20050 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC85_20060 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC85_20065 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC85_20070 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC85_20075 ENOG4105C8J )-transporter FOC85_20095 ENOG4105DFD Na H antiporter FOC85_20115 ENOG4105ENE Histidine kinase FOC85_20120 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_20140 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC85_20185 ENOG4105CJ3 phosphate transporter FOC85_20190 ENOG4107GRR phosphate transport regulator FOC85_20195 ENOG4105BZ4 penicillin-binding protein FOC85_20210 ENOG4105BZU Histidine kinase FOC85_20215 ENOG4105I3N Conserved Protein FOC85_20230 ENOG4105BZU Histidine kinase FOC85_20260 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC85_20265 ENOG4105DZ1 carboxypeptidase FOC85_20270 ENOG4108JIC nucleoside recognition domain protein FOC85_20280 ENOG4105FE9 pseudouridine synthase FOC85_20290 ENOG4107TWT Cytochrome c biogenesis protein FOC85_20295 ENOG4105CRE cytochrome C FOC85_20300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_20305 ENOG4105BZU Histidine kinase FOC85_20310 ENOG4108WBT adenosyltransferase FOC85_20315 ENOG41063SB peptidase FOC85_20325 ENOG4108SAX Membrane FOC85_20340 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC85_20345 ENOG4105I7S Abortive infection protein FOC85_20355 ENOG4107RGJ metallophosphoesterase FOC85_20360 ENOG4107X2D transcriptional regulator, merr family FOC85_20365 ENOG4108S6Z Negative regulator of genetic competence FOC85_20390 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC85_20395 ENOG4105HDK L-asparaginase FOC85_20430 ENOG4105S2F FOC85_20435 ENOG41065D1 FOC85_20465 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC85_20480 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC85_20490 ENOG4105EAH synthase FOC85_20510 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC85_20515 ENOG41068YB TPR repeat-containing protein FOC85_20530 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC85_20535 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC85_20540 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC85_20570 ENOG4108JYZ YitT family FOC85_20575 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC85_20590 ENOG4105FJR Lmbe family FOC85_20595 ENOG4105CPK Glycosyl transferase (Group 1 FOC85_20630 ENOG4105DVT helicase FOC85_20635 ENOG4105YAC FOC85_20655 ENOG4105CSM endonuclease III FOC85_20665 ENOG4105BZ4 penicillin-binding protein FOC85_20725 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC85_20735 ENOG4105DVT helicase FOC85_20740 ENOG4105CTD carboxy-peptidase FOC85_20755 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC85_20765 ENOG4105C2W permease FOC85_20770 ENOG4105DHF Membrane FOC85_20775 ENOG410890F Dynamin family FOC85_20785 ENOG4108W0I acetyltransferase FOC85_20795 ENOG4105KHC sulfurtransferase FOC85_20820 ENOG4106032 Glutathionylspermidine synthase FOC85_20850 ENOG4108SZE gCN5-related N-acetyltransferase FOC85_20870 ENOG41081VK Ribonuclease FOC85_20935 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC85_20945 ENOG4107RWR Sodium hydrogen exchanger FOC85_20950 ENOG4105CN5 Metallo-Beta-Lactamase FOC85_20955 ENOG4108Z5V transcriptional regulator, merr family FOC85_20965 ENOG4105H67 Protein of unknown function (DUF421) FOC85_20970 ENOG41080C8 DUF218 domain FOC85_21025 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC85_21035 ENOG4107R0U MotA TolQ exbB proton channel FOC85_21040 ENOG4105ER2 Ompa motb domain protein FOC85_21045 ENOG4107YTP response regulator receiver protein FOC85_21050 ENOG4105CBS Chea signal transduction histidine kinase FOC85_21055 ENOG4105DD5 Flagellar motor switch protein FOC85_21070 ENOG4105BZU Histidine kinase FOC85_21090 ENOG4105E1Q flagellar hook-associated protein FOC85_21095 ENOG4105DTJ flagellar hook-associated protein FOC85_21100 ENOG4107TPX flagellar hook-associated FOC85_21115 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC85_21120 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC85_21130 ENOG4107U2N Flagellar M-ring protein FOC85_21135 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC85_21165 ENOG4105BZE flagellar hook protein, FlgE FOC85_21180 ENOG4107R88 Chemotaxis protein (CheV) FOC85_21190 ENOG4105I03 Flagellin FOC85_21195 ENOG4105I03 Flagellin FOC85_21200 ENOG4105E4C Lytic transglycosylase catalytic FOC85_21210 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC85_21215 ENOG4105DD5 Flagellar motor switch protein FOC85_21225 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC85_21230 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC85_21240 ENOG4105D00 flagellar biosynthetic protein flhB FOC85_21245 ENOG4105D7B Flagellar biosynthesis protein flha FOC85_21250 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC85_21255 ENOG4105KTQ flagellar basal-body rod protein FOC85_21260 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC85_21285 ENOG41062JF Transcriptional regulator FOC85_21315 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC85_21345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC85_21355 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC85_21360 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC85_21400 ENOG4105CVJ phosphoglycerate mutase FOC85_21420 ENOG4105K56 Transcriptional regulator FOC85_21430 ENOG4105CAQ asparagine synthetase FOC85_21450 ENOG4105PGM cation diffusion facilitator family transporter FOC85_21460 ENOG4105DRR Transcriptional regulator, GntR family FOC85_21465 ENOG4108UZ3 Transporter FOC85_21470 ENOG4105CKI cobalamin synthesis protein FOC85_21475 ENOG4108PJD permease FOC85_21490 ENOG4105DFD Na H antiporter FOC85_21495 ENOG4105C9Q fumarate hydratase class II FOC85_21510 ENOG4107QJQ Mate efflux family protein FOC85_21515 ENOG4105EC3 peptidase S51, dipeptidase E FOC85_21535 ENOG4107QIV Cytochrome c biogenesis protein FOC85_21565 ENOG4106BRA Membrane FOC85_21600 ENOG4105CJ1 ABC, transporter FOC85_21620 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC85_21630 ENOG4108IJ0 Aspartate ammonia-lyase FOC85_21635 ENOG4105C6K Malic enzyme FOC85_21670 ENOG41067QW Transcriptional regulator FOC85_21690 ENOG4105FVX FOC85_21725 ENOG4105CSR polyphosphate kinase 2 FOC85_21730 ENOG4105DXI Major Facilitator superfamily FOC85_21745 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC85_21755 ENOG4105EU0 Major facilitator Superfamily FOC85_21760 ENOG4105C6T cysteine synthase FOC85_21780 ENOG4105C8J )-transporter FOC85_21790 ENOG4105X5K response regulator receiver protein FOC85_21795 ENOG4105H67 Protein of unknown function (DUF421) FOC85_21815 ENOG4106KE4 Dehydrogenase FOC85_21830 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC85_21835 ENOG4105CHR reductase FOC85_21840 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC85_21845 ENOG4105C7K acetolactate synthase FOC85_21855 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC85_21865 ENOG4105C7B Threonine dehydratase FOC85_21890 ENOG4105C6X Major Facilitator FOC85_21895 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC85_21915 ENOG4105DY9 regulatoR FOC85_21920 ENOG4105CYC Transferase FOC85_21980 ENOG41068WN FOC85_21985 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_22005 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC85_22020 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC85_22025 ENOG4105C0X amino acid FOC85_22070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_22080 ENOG4107RHR regulatoR FOC85_22090 ENOG4105D9N nucleoside FOC85_22095 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC85_22125 ENOG4107RAQ aminopeptidase FOC85_22130 ENOG4107R16 Multicopper oxidase FOC85_22175 ENOG4108T5E Copper resistance protein FOC85_22180 ENOG4105KTB nuclear export factor GLE1 FOC85_22185 ENOG4107RT3 EamA-like transporter family FOC85_22190 ENOG4105GZI Transcriptional regulator FOC85_22195 ENOG4108Z40 Transcriptional regulator FOC85_22200 ENOG4107ZXU DSBA oxidoreductase FOC85_22205 ENOG4108TVJ Nitroreductase FOC85_22210 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC85_22215 ENOG4106F5Q Membrane FOC85_22230 ENOG4105CKI cobalamin synthesis protein FOC85_22250 ENOG4108Z7G MaoC domain protein dehydratase FOC85_22255 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC85_22265 ENOG4105C0Z ABC transporter FOC85_22270 ENOG4108IV0 ABC, transporter FOC85_22275 ENOG4105C32 Amino acid ABC transporter (Permease) FOC85_22285 ENOG4105EGI Transcriptional regulator FOC85_22295 ENOG4105MDS 4-oxalocrotonate tautomerase FOC85_22315 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC85_22320 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC85_22325 ENOG4108JJ9 ABC, transporter FOC85_22330 ENOG4108JJ8 (ABC) transporter FOC85_22375 ENOG4105BZ1 (ABC) transporter FOC85_22380 ENOG4105EFI regulatoR FOC85_22385 ENOG4105EB3 Histidine kinase FOC85_22405 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC85_22430 ENOG4105D6E homoserine dehydrogenase FOC85_22455 ENOG4108KGH TRANSCRIPTIONal FOC85_22465 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_22470 ENOG4105BZU Histidine kinase FOC85_22485 ENOG4105KT7 mgtC SapB transporter FOC85_22490 ENOG4105VRR gCN5-related N-acetyltransferase FOC85_22500 ENOG4105DUU IucA IucC family protein FOC85_22505 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_22520 ENOG4108WBH protein TIM barrel FOC85_22525 ENOG4105YWU small acid-soluble spore protein FOC85_22535 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC85_22540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC85_22590 ENOG4105KRN Transcriptional regulator, abrb family FOC85_22600 ENOG4105YVS arsR family transcriptional regulator FOC85_22605 ENOG4107SET aldo keto reductase FOC85_22610 ENOG4107XZQ multidrug resistance protein FOC85_22635 ENOG4105C8Q Methyl-accepting chemotaxis FOC85_22650 ENOG4108K88 Membrane FOC85_22655 ENOG4108WPJ Ferritin-like domain FOC85_22670 ENOG4105DEN Luciferase family FOC85_22690 ENOG4107QM2 Aldo Keto reductase FOC85_22695 ENOG4105CKI cobalamin synthesis protein FOC85_22715 ENOG4108IBT Inherit from COG: transposase FOC85_22720 ENOG4105DSE periplasmic solute binding protein FOC85_22730 ENOG4105K4T epimerase FOC85_22740 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC85_22765 ENOG4105CVJ phosphoglycerate mutase FOC85_22785 ENOG4107T5V SNARE associated Golgi FOC85_22800 ENOG4108PJD permease FOC85_22810 ENOG4108S4H thioesterase Superfamily protein FOC85_22820 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC85_22840 ENOG4105SXS Protein of unknown function (DUF456) FOC85_22845 ENOG4105C37 (CBS) domain FOC85_22865 ENOG4108Z7R Chaperone CsaA FOC85_22885 ENOG4108ZRV stage ii sporulation protein p FOC85_22895 ENOG4108VXD carboxy-peptidase FOC85_22925 ENOG4105EFA 4-hydroxyphenylacetate FOC85_22935 ENOG4105U1N riboflavin FOC85_22950 ENOG4105KME endoribonuclease L-psp FOC85_22960 ENOG4105IKQ hydratase FOC85_22980 ENOG41069HH 4-oxalocrotonate tautomerase FOC85_22990 ENOG4108X4Q Hydrolase FOC85_23000 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC85_23020 ENOG41087PP glycosyltransferase MGT family FOC85_23025 ENOG4108JYZ YitT family FOC85_23030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC85_23060 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC85_23140 ENOG4105KBJ sporulation protein ytfj FOC85_23165 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC85_23190 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC85_23200 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC85_23205 ENOG4105EMN RNA polymerase sigma factor FOC85_23220 ENOG4105CNW domain protein FOC85_23230 ENOG4108V06 Glutathione peroxidase FOC85_23245 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC85_23265 ENOG4108IUE nitrate reductase beta subunit FOC85_23270 ENOG4105R3A Nitrate reductase FOC85_23280 ENOG4107V6Q Cyclic nucleotide-binding domain FOC85_23285 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC85_23290 ENOG4105D06 uba thif-type nad fad binding protein FOC85_23300 ENOG4108ZAF Molybdopterin FOC85_23320 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC85_23325 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC85_23330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC85_23335 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC85_23340 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC85_23345 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC85_23370 ENOG4105MCT stage V sporulation protein S FOC85_23435 ENOG4105C5H ABC transporter FOC85_23450 ENOG4108UUM single-stranded DNA-binding protein FOC85_23480 ENOG4107YX5 Pfam:DUF548 FOC85_23525 ENOG4105C5S asparaginyl-tRNA synthetase FOC85_23545 ENOG4105EC2 ftsk spoIIIe FOC85_23665 ENOG4105BZW Glycerate kinase FOC85_23670 ENOG4107QPK )-transporter FOC85_23675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_23680 ENOG41062D9 Histidine kinase FOC85_23695 ENOG4105C8J )-transporter FOC85_23715 ENOG4107XGZ Hydrolase FOC85_23720 ENOG4105CY2 Citrate transporter FOC85_23725 ENOG4105C0A alcohol dehydrogenase FOC85_23740 ENOG4105KD7 acetyltransferase FOC85_23745 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC85_23770 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC85_23790 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC85_23810 ENOG4107RVG penicillin-binding protein FOC85_23820 ENOG4105E9Q Acyl-transferase FOC85_23825 ENOG4108UT2 hemolysin iii FOC85_23835 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC85_23845 ENOG4108RCR degv family FOC85_23850 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC85_23855 ENOG4108KF3 Electron transport protein SCO1 SenC FOC85_23860 ENOG4107Y70 Heat shock protein FOC85_23865 ENOG4105CAQ asparagine synthetase FOC85_23885 ENOG4108MES Periplasmic binding protein FOC85_23890 ENOG4105F0I Aminotransferase FOC85_23925 ENOG4105D8X mechanosensitive ion channel FOC85_23930 ENOG4105BZU Histidine kinase FOC85_23935 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_23970 ENOG4105CMG Carbohydrate kinase FOC85_24000 ENOG4108IJ8 ABC transporter FOC85_24005 ENOG4105E90 ABC transporter FOC85_24040 ENOG4105C37 (CBS) domain FOC85_24065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC85_24080 ENOG4107S4Y M20 DapE family protein YgeY FOC85_24085 ENOG4108TSC N-acetyltransferase FOC85_24090 ENOG4108JUB Transcriptional regulator FOC85_24095 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC85_24135 ENOG4108N23 SpoOM-related protein FOC85_24140 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC85_24150 ENOG4105SZ6 Thioredoxin FOC85_24210 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC85_24265 ENOG4105BZ4 penicillin-binding protein FOC85_24275 ENOG4105W8X HesB YadR YfhF-family protein FOC85_24285 ENOG4105DXD 2-methylcitrate dehydratase FOC85_24290 ENOG4105CR4 methylisocitrate lyase FOC85_24295 ENOG4105C1G acyl-Coa dehydrogenase FOC85_24300 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC85_24310 ENOG4105N14 lysine exporter protein LysE YggA FOC85_24315 ENOG4105E39 Enoyl-CoA hydratase FOC85_24330 ENOG4107RFY SbcCD D subunit FOC85_24335 ENOG4105EYH Exonuclease FOC85_24355 ENOG4105FCD Major Facilitator FOC85_24360 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC85_24365 ENOG4105E4F Isochorismate synthase FOC85_24370 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC85_24375 ENOG4105WQI isochorismatase FOC85_24380 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_24385 ENOG4105WQT MbtH domain protein FOC85_24390 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_24405 ENOG4105K70 DNA-binding protein FOC85_24425 ENOG4105BZG amino acid carrier protein FOC85_24445 ENOG4105FE9 pseudouridine synthase FOC85_24450 ENOG4105C22 threonyL-tRNA synthetase FOC85_24460 ENOG4105C19 ABC transporter FOC85_24470 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC85_24495 ENOG4108D32 Methyltransferase FOC85_24525 ENOG41081I9 integral membrane protein FOC85_24540 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC85_24550 ENOG4105EYF MMPL domain protein FOC85_24575 ENOG4105WCN acetyltransferase FOC85_24605 ENOG4105C1Q protoporphyrinogen oxidase FOC85_24615 ENOG41089UC methyltransferase, type 11 FOC85_24620 ENOG41068WN FOC85_24630 ENOG4105VEQ Cold shock protein FOC85_24655 ENOG4107V2S Transcriptional regulator FOC85_24660 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC85_24675 ENOG4105DND Transcriptional regulator FOC85_24680 ENOG4108RPX mosc domain containing protein FOC85_24695 ENOG4105BZ1 (ABC) transporter FOC85_24700 ENOG4105BZ1 (ABC) transporter FOC85_24720 ENOG4108JCI Transcriptional regulator FOC85_24750 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC85_24760 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC85_24765 ENOG4108KPJ rna polymerase sigma factor FOC85_24790 ENOG4105F32 YngK protein FOC85_24815 ENOG4105RD7 BadF BadG BcrA BcrD FOC85_24825 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC85_24860 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC85_24875 ENOG4105C1J atp-dependent rna helicase FOC85_24950 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC85_24975 ENOG41088CC tellurite resistance protein tehB FOC85_25070 ENOG41090HR transcriptional regulator FOC85_25105 ENOG4105CIN aminoacyl-histidine dipeptidase FOC85_25115 ENOG4105EQK -acetyltransferase FOC85_25130 ENOG4107RVG penicillin-binding protein FOC85_25145 ENOG4107RF6 penicillin-binding protein FOC85_25150 ENOG4107RF6 penicillin-binding protein FOC85_25165 ENOG4105ETE Transcriptional regulator (LacI family FOC85_25170 ENOG4105IE8 Alpha-ketoglutarate permease FOC85_25175 ENOG4105CK5 oxidoreductase FOC85_25200 ENOG4105D2N Aldolase FOC85_25205 ENOG4105DH8 myo-inositol catabolism FOC85_25230 ENOG4105CGH 5'-nucleotidase FOC85_25240 ENOG4107JM4 Tetratricopeptide repeat FOC85_25245 ENOG4105VZ8 Transcriptional regulator FOC85_25260 ENOG4108VXD carboxy-peptidase FOC85_25275 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC85_25280 ENOG41067SE Tetr family transcriptional regulator FOC85_25285 ENOG4105C5H ABC transporter FOC85_25315 ENOG4105CEP NADH dehydrogenase FOC85_25320 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC85_25350 ENOG4105C1G acyl-Coa dehydrogenase FOC85_25355 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC85_25360 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC85_25365 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC85_25370 ENOG4105E39 Enoyl-CoA hydratase FOC85_25375 ENOG4107QX3 carboxylase FOC85_25380 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC85_25390 ENOG4105WCN acetyltransferase FOC85_25395 ENOG4105DBI uridine monophosphokinase FOC85_25425 ENOG4105T9C HD domain FOC85_25435 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC85_25475 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC85_25475 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC85_25520 ENOG4105CUV Homoserine Kinase FOC85_25580 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC85_25590 ENOG4105DK7 lysyl-tRNA synthetase FOC85_25675 ENOG4105ETU transcriptional activator (TenA FOC85_25785 ENOG410667J hydrolase FOC85_25790 ENOG4105BZU Histidine kinase FOC85_25795 ENOG4107RF6 penicillin-binding protein FOC85_25830 ENOG4108HGU Histidine kinase FOC85_25840 ENOG4105RHY Pfam:UPF0157 FOC85_25845 ENOG4105CB2 alcohol dehydrogenase FOC85_25850 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC85_25855 ENOG4105CJN penicillin-binding protein FOC85_25860 ENOG4108IG5 Transcriptional regulator FOC85_25865 ENOG4107GJV short-chain dehydrogenase reductase FOC85_25875 ENOG4105FQP Beta-lactamase FOC85_25915 ENOG4108V4B ThiJ pfpI FOC85_25930 ENOG4107Y80 Major Facilitator superfamily FOC85_25945 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC85_25970 ENOG4107Y9U Membrane FOC85_26005 ENOG4105FCD Major Facilitator FOC85_26010 ENOG4105E09 nadh pyrophosphatase FOC85_26015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC85_26020 ENOG4108Z4K mutator MutT protein FOC85_26040 ENOG4107TB6 phosphoglycerate mutase FOC85_26050 ENOG4108XI2 Domain of unknown function (DUF1963) FOC85_26070 ENOG4108NRW Phospholipase, patatin family FOC85_26075 ENOG4105KWG Pfam:DUF1696 FOC85_26110 ENOG4105PKS Excinuclease abc c subunit domain protein FOC85_26145 ENOG4107VFR oxidoreductase FOC85_26190 ENOG4108IUM Glycogen debranching enzyme FOC85_26215 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC85_26220 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC85_26230 ENOG4105FDR Membrane FOC85_26285 ENOG4105MSI germination protein ypeb FOC85_26320 ENOG4107Z3H Transcriptional regulator, TetR family FOC85_26355 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC85_26370 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC85_26375 ENOG4105E98 transcriptional regulator DeoR family FOC85_26395 ENOG41062ES Transcriptional regulator FOC85_26415 ENOG4107QKR Dehydrogenase FOC85_26425 ENOG4107RUY (E1 component), alpha subunit FOC85_26435 ENOG4105E1F short-chain dehydrogenase reductase FOC85_26440 ENOG4105RHY Pfam:UPF0157 FOC85_26445 ENOG4105DBI uridine monophosphokinase FOC85_26455 ENOG4105M6F mutator MutT protein FOC85_26480 ENOG4107SQ8 Glycine betaine FOC85_26485 ENOG4108IJ7 Glycine betaine FOC85_26510 ENOG4105E66 phosphoriboisomerase A FOC85_26515 ENOG41082BV acetyltransferase FOC85_26520 ENOG4108M1A Chitin-binding protein FOC85_26535 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC85_26540 ENOG4105MSB protein, conserved in bacteria FOC85_26545 ENOG4107YB6 acetyltransferase, (GNAT) family FOC85_26550 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC85_26580 ENOG4108Z7F N-acetyltransferase FOC85_26600 ENOG4105EEM helicase FOC85_26620 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC85_26670 ENOG4108M1A Chitin-binding protein FOC85_26690 ENOG4105BZG amino acid carrier protein FOC85_26695 ENOG4105C26 Dehydrogenase FOC85_26700 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC85_26705 ENOG4105CTU Proline racemase FOC85_26710 ENOG4105CTU Proline racemase FOC85_26715 ENOG41080HI glycine oxidase FOC85_26725 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC85_26755 ENOG4107T5V SNARE associated Golgi FOC85_26770 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC85_26775 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC85_26790 ENOG4105DTQ mandelate racemase muconate lactonizing FOC85_26835 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC85_26840 ENOG4105BZU Histidine kinase FOC85_26845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_26875 ENOG4105DPN Oligoendopeptidase f FOC85_26880 ENOG4105DVH amino acid FOC85_26890 ENOG4105EPR degv family FOC85_26950 ENOG4106K7D Major facilitator family transporter FOC85_26970 ENOG4107BMA Transglycosylase associated protein FOC85_26985 ENOG41089UC methyltransferase, type 11 FOC85_27015 ENOG4105CHM Aminotransferase FOC85_27030 ENOG4108ZMI UPF0477 protein FOC85_27045 ENOG4105DVE abc transporter atp-binding protein FOC85_27090 ENOG4105C02 permease FOC85_27100 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC85_27105 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC85_27110 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC85_27125 ENOG4105E09 nadh pyrophosphatase FOC85_27145 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC85_27215 ENOG4108ZCF integral membrane protein FOC85_27220 ENOG4105E0M Sulfatase FOC85_27225 ENOG4105C5H ABC transporter FOC85_27235 ENOG4105EYF MMPL domain protein FOC85_27240 ENOG41082JN Transcriptional regulator FOC85_27260 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC85_27270 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC85_27290 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC85_27310 ENOG41069ER domain protein FOC85_27320 ENOG4105CY2 Citrate transporter FOC85_27325 ENOG4105E39 Enoyl-CoA hydratase FOC85_27330 ENOG4105J5T Amp-dependent synthetase and ligase FOC85_27335 ENOG4108JUB Transcriptional regulator FOC85_27350 ENOG4105D4B ABC, transporter FOC85_27355 ENOG4105F5R ABC transporter FOC85_27360 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC85_27370 ENOG4105DKT Transcriptional regulator FOC85_27375 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC85_27385 ENOG41061GT Aldolase FOC85_27410 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC85_27445 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_27455 ENOG4107258 Transcriptional regulator FOC85_27465 ENOG4105E0Y RtcB Protein FOC85_27470 ENOG4105ECK Fatty Acid Desaturase