locus-tag class description FOC87_00020 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC87_00025 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC87_00040 ENOG4105C2M dna polymerase I FOC87_00045 ENOG4105BZU Histidine kinase FOC87_00050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_00070 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC87_00075 ENOG4105BZN citrate synthase FOC87_00085 ENOG4108REF Sporulation integral membrane protein ytvi FOC87_00090 ENOG4105FS0 cytoplasmic membrane protein FOC87_00115 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC87_00120 ENOG4105C6K Malic enzyme FOC87_00125 ENOG4105C0B DNA polymerase III (alpha subunit) FOC87_00130 ENOG4105VV2 FOC87_00140 ENOG4105SFS phosphoesterase RecJ domain protein FOC87_00180 ENOG4105DC7 peptidase M24 FOC87_00225 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC87_00235 ENOG4105VZ8 Transcriptional regulator FOC87_00255 ENOG4107YZX Universal stress protein FOC87_00295 ENOG4108JYZ YitT family FOC87_00310 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC87_00320 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC87_00325 ENOG4105KBJ sporulation protein ytfj FOC87_00340 ENOG4105EFZ amidohydrolase FOC87_00350 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC87_00375 ENOG4106KR7 LysR family Transcriptional regulator FOC87_00385 ENOG4105U5Y Transcriptional regulator FOC87_00395 ENOG4105C28 cystathionine FOC87_00445 ENOG4105EMN RNA polymerase sigma factor FOC87_00460 ENOG4105F1V Acetoin utilization protein FOC87_00465 ENOG4105W87 Cbs domain FOC87_00470 ENOG4105DGU Histone deacetylase FOC87_00485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_00495 ENOG4107SNB ankyrin repeat protein YahD FOC87_00500 ENOG4105EP9 oxidoreductase FOC87_00530 ENOG4105ETE Transcriptional regulator (LacI family FOC87_00550 ENOG4105C88 aminopeptidase FOC87_00595 ENOG4108VDD TRNA binding domain protein FOC87_00625 ENOG4105C8F Beta-lactamase domain protein FOC87_00640 ENOG4108V15 phosphotransferase enzyme family FOC87_00645 ENOG4108IUM Glycogen debranching enzyme FOC87_00655 ENOG4107QSE Dipeptidase FOC87_00660 ENOG4105YW5 deoR family transcriptional regulator FOC87_00675 ENOG4105CBX hi0933 family FOC87_00710 ENOG4108VJ1 Transcriptional regulator (CarD family FOC87_00715 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC87_00735 ENOG4108ZAF Molybdopterin FOC87_00740 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC87_00745 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC87_00755 ENOG4105D06 uba thif-type nad fad binding protein FOC87_00760 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC87_00780 ENOG41085GJ domain protein FOC87_00790 ENOG4105DWV Homoserine O-trans-acetylase FOC87_00800 ENOG4108B31 Spore germination protein FOC87_00835 ENOG410605W Major Facilitator FOC87_00840 ENOG4107S91 Sodium hydrogen exchanger FOC87_00845 ENOG4105NCW Trka-c domain protein FOC87_00860 ENOG4105C19 ABC transporter FOC87_00880 ENOG4105N5T Radical SAM Protein FOC87_00890 ENOG4105CIG ABC transporter FOC87_00935 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC87_00940 ENOG4108Z0R Transferase FOC87_00945 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC87_00950 ENOG4105BZF Glycosyl transferase (Group 1 FOC87_00960 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC87_01025 ENOG4107XGZ Hydrolase FOC87_01030 ENOG4105E98 transcriptional regulator DeoR family FOC87_01040 ENOG4105BZU Histidine kinase FOC87_01045 ENOG4105BZU Histidine kinase FOC87_01050 ENOG4107S9D Alpha beta hydrolase FOC87_01055 ENOG4107T7U Sulfatase FOC87_01070 ENOG4105D2X ABC transporter substrate-binding protein FOC87_01080 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC87_01095 ENOG4107XGZ Hydrolase FOC87_01140 ENOG4108V2W Carbonate dehydratase FOC87_01145 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC87_01150 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC87_01195 ENOG41087YS Phage shock protein A FOC87_01255 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FOC87_01260 ENOG4105BZU Histidine kinase FOC87_01265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_01290 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC87_01295 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC87_01305 ENOG4105D7V transposase FOC87_01325 ENOG4107ZTW SNARE associated Golgi FOC87_01335 ENOG41063TF transcriptional regulator (AraC FOC87_01350 ENOG4105C19 ABC transporter FOC87_01355 ENOG41086D8 Transcriptional regulator FOC87_01395 ENOG4105C6Z Gluconate FOC87_01420 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC87_01440 ENOG4105DTQ mandelate racemase muconate lactonizing FOC87_01450 ENOG4108IPT Naphthoate synthase FOC87_01455 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC87_01465 ENOG4105E4F Isochorismate synthase FOC87_01470 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC87_01480 ENOG4105VEQ Cold shock protein FOC87_01525 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC87_01625 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC87_01660 ENOG4105KT7 mgtC SapB transporter FOC87_01665 ENOG4107PBV potassium channel FOC87_01680 ENOG4105WG9 Conserved Protein FOC87_01690 ENOG4105CHM Aminotransferase FOC87_01695 ENOG4108ZB6 transcriptional regulator AsnC family FOC87_01700 ENOG4105C5I Dehydrogenase FOC87_01705 ENOG4108MUZ hydrolase FOC87_01715 ENOG4105C87 Aminotransferase class I and II FOC87_01730 ENOG4105Y38 Kinase-associated protein B FOC87_01740 ENOG4107R3E Citrate transporter FOC87_01760 ENOG4105KA0 thioesterase Superfamily protein FOC87_01775 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC87_01795 ENOG41069ER domain protein FOC87_01810 ENOG4105CEP NADH dehydrogenase FOC87_01840 ENOG4105EWC Purine nucleoside phosphorylase FOC87_01850 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC87_01875 ENOG4108JJA ABC, transporter FOC87_01880 ENOG4105C4B ABC transporter, permease FOC87_01885 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC87_01910 ENOG41083MR nifu domain-containing protein FOC87_01925 ENOG4108W5N phosphatidylglycerophosphatase a FOC87_01940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC87_01945 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC87_01950 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC87_01965 ENOG4105CBT Fructose-1,6-bisphosphatase FOC87_01980 ENOG4105MMD transcriptional regulator FOC87_01985 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC87_01990 ENOG4107TXC Transcriptional regulator FOC87_01995 ENOG41090T1 Membrane FOC87_02020 ENOG4105FAA peptidase M23 FOC87_02030 ENOG4105KZD Domain of unknown function (DUF1805) FOC87_02035 ENOG4107R8B 5'-nucleotidase FOC87_02050 ENOG4105DIW FeS assembly protein SUFB FOC87_02055 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC87_02060 ENOG4105C9B Cysteine desulfurase FOC87_02065 ENOG4105JRK feS assembly protein SufD FOC87_02070 ENOG4105C3K feS assembly ATPase SufC FOC87_02075 ENOG4105D01 (LipO)protein FOC87_02080 ENOG4105D01 (LipO)protein FOC87_02085 ENOG4108UMI ABC transporter, permease FOC87_02115 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC87_02160 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC87_02185 ENOG4108IMY Transcriptional regulator FOC87_02195 ENOG4108W8B Beta-lactamase domain protein FOC87_02205 ENOG4108IUW ABC transporter FOC87_02230 ENOG4105C1G acyl-Coa dehydrogenase FOC87_02235 ENOG4105CHU acetyl-coa acetyltransferase FOC87_02250 ENOG4105DZ1 carboxypeptidase FOC87_02270 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC87_02290 ENOG4108SUT Major Facilitator Superfamily FOC87_02295 ENOG4107R7I amino acid FOC87_02310 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC87_02320 ENOG4107AYK membrAne FOC87_02355 ENOG4107ZTW SNARE associated Golgi FOC87_02365 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC87_02370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_02375 ENOG4105BZU Histidine kinase FOC87_02395 ENOG4105C8Q Methyl-accepting chemotaxis FOC87_02400 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC87_02405 ENOG4105VG1 fes assembly suf system protein FOC87_02410 ENOG4105D4Y metalloprotease FOC87_02430 ENOG4107S91 Sodium hydrogen exchanger FOC87_02435 ENOG4105NCW Trka-c domain protein FOC87_02445 ENOG4108RMU ferritin dps family protein FOC87_02460 ENOG4108URH decarboxylase FOC87_02480 ENOG4105D9N nucleoside FOC87_02485 ENOG4105D9N nucleoside FOC87_02500 ENOG4108RYK Nad-dependent epimerase dehydratase FOC87_02515 ENOG4105CV8 reductase FOC87_02520 ENOG4105F27 Major Facilitator FOC87_02525 ENOG4105KVH Transcriptional regulator FOC87_02540 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC87_02565 ENOG4105WMR Protein CrcB homolog FOC87_02590 ENOG4105C5H ABC transporter FOC87_02595 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC87_02615 ENOG4108IPW abc transporter atp-binding protein FOC87_02620 ENOG4105CM4 permease protein FOC87_02635 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_02650 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC87_02660 ENOG4105XZU Preprotein translocase, subunit SecG FOC87_02665 ENOG41067MG lrgb family FOC87_02715 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_02735 ENOG41090VF Stage v sporulation protein ac FOC87_02740 ENOG4105CZ3 stage V sporulation protein ad FOC87_02755 ENOG4105H67 Protein of unknown function (DUF421) FOC87_02765 ENOG4105KRI phosphocarrier protein (HPr FOC87_02775 ENOG4105CHW UPF0052 protein FOC87_02785 ENOG4108Z4K mutator MutT protein FOC87_02795 ENOG4105C3M thioredoxin reductase FOC87_02805 ENOG4108S4C acetyltransferase FOC87_02825 ENOG41086DT Membrane protein of unknown function FOC87_02875 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC87_02880 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC87_02895 ENOG4107TXC Transcriptional regulator FOC87_02920 ENOG4105HMI Membrane FOC87_02925 ENOG4105DUM transcriptional regulator, lysR family FOC87_02935 ENOG4108WS4 fmn reductase FOC87_02940 ENOG4105C5H ABC transporter FOC87_02950 ENOG4105BZ1 (ABC) transporter FOC87_02960 ENOG4105CN1 protease FOC87_02965 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC87_02970 ENOG4105CAK Cell division ATP-binding protein ftsE FOC87_02990 ENOG4105MS2 ribosomal subunit Interface protein FOC87_02995 ENOG4105VEQ Cold shock protein FOC87_03000 ENOG41081UC Inherit from COG: Competence protein FOC87_03015 ENOG4105KVH Transcriptional regulator FOC87_03025 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC87_03030 ENOG4108KGH TRANSCRIPTIONal FOC87_03035 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC87_03040 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC87_03045 ENOG4105ESV Glycosyl transferase, family 4 FOC87_03055 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC87_03075 ENOG4105F8D glycoside hydrolase family 4 FOC87_03080 ENOG4105VCP PTS System FOC87_03085 ENOG4105CK1 PTS System FOC87_03095 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC87_03115 ENOG4105VCP PTS System FOC87_03125 ENOG4105VZJ PTS System FOC87_03140 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC87_03160 ENOG4105ECB domain protein FOC87_03165 ENOG4107RSM transcriptional regulator FOC87_03200 ENOG4105DAA L-lactate FOC87_03205 ENOG4105D7V transposase FOC87_03215 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC87_03225 ENOG4105E0M Sulfatase FOC87_03250 ENOG4107R8N Glycosyl transferase, family 2 FOC87_03255 ENOG4105C94 Transporter FOC87_03260 ENOG41069ER domain protein FOC87_03285 ENOG4105KBK Zinc finger, swim domain protein FOC87_03290 ENOG4105C0D helicase FOC87_03320 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_03335 ENOG4107RBB ABC transporter, permease FOC87_03340 ENOG4105C19 ABC transporter FOC87_03360 ENOG4105CXY transporter FOC87_03380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_03385 ENOG4105DG6 mannose-6-phosphate isomerase FOC87_03390 ENOG4105DM4 PTS System FOC87_03400 ENOG4105CMR udp-glucose 4-epimerase FOC87_03410 ENOG4108KGH TRANSCRIPTIONal FOC87_03415 ENOG4105DG6 mannose-6-phosphate isomerase FOC87_03420 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOC87_03425 ENOG4105CPK Glycosyl transferase (Group 1 FOC87_03430 ENOG4108TJN glycosyl transferase group 1 FOC87_03435 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC87_03455 ENOG4105D3Q Sugar transferase FOC87_03460 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC87_03465 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC87_03470 ENOG4107YJ4 chain length determinant protein FOC87_03475 ENOG4105HTX biosynthesis protein FOC87_03480 ENOG4107YJ4 chain length determinant protein FOC87_03495 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC87_03505 ENOG4105FRN stage II sporulation protein FOC87_03520 ENOG4105DY9 regulatoR FOC87_03540 ENOG4106778 Protein of unknown function (DUF1146) FOC87_03545 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC87_03550 ENOG4105C8S subunit m FOC87_03555 ENOG4105D65 subunit l FOC87_03585 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC87_03600 ENOG4105BZU Histidine kinase FOC87_03650 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC87_03655 ENOG41062M3 atp synthase FOC87_03685 ENOG4108YZG isomerase FOC87_03700 ENOG4108VGI doxx family FOC87_03705 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC87_03720 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC87_03730 ENOG4108ZXQ stage ii sporulation protein r FOC87_03735 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC87_03755 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC87_03760 ENOG4105CBT Fructose-1,6-bisphosphatase FOC87_03800 ENOG4105C1G acyl-Coa dehydrogenase FOC87_03805 ENOG4105C1G acyl-Coa dehydrogenase FOC87_03810 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC87_03820 ENOG4105DF6 Fe-S oxidoreductase FOC87_03835 ENOG4105BZU Histidine kinase FOC87_03860 ENOG4105BZU Histidine kinase FOC87_03865 ENOG4105KCT ABC transporter FOC87_03870 ENOG4108M15 ABC transporter FOC87_03875 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC87_03885 ENOG4105IIU Aminopeptidase FOC87_03905 ENOG4105EMN RNA polymerase sigma factor FOC87_03915 ENOG410684U Domain of unknown function (DUF1934) FOC87_03935 ENOG4105CYW agmatinase FOC87_03945 ENOG4105DXB Major Facilitator superfamily FOC87_03950 ENOG4107SWG transcriptional regulator MERR family FOC87_03955 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC87_03960 ENOG4105BZ4 penicillin-binding protein FOC87_03965 ENOG4108XFG YwhD family FOC87_03970 ENOG4108Z4T Peptidase M50 FOC87_03975 ENOG41069HH 4-oxalocrotonate tautomerase FOC87_03980 ENOG4105DCI Phosphohydrolase FOC87_03985 ENOG4108MES Periplasmic binding protein FOC87_03990 ENOG4105E0A ABC, transporter FOC87_03995 ENOG4105EHG Permease protein FOC87_04000 ENOG4105DQ5 transport system permease protein FOC87_04010 ENOG4108VCI transcription factor, rsfa family FOC87_04025 ENOG4108IJ2 phosphate acetyltransferase FOC87_04040 ENOG4108VKI Cell wall hydrolase FOC87_04060 ENOG4107SVH Potassium channel protein FOC87_04070 ENOG410667J hydrolase FOC87_04075 ENOG4105VCH membrane FOC87_04085 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC87_04090 ENOG4105CJ1 ABC, transporter FOC87_04095 ENOG41090WU lipolytic protein G-D-S-L family FOC87_04110 ENOG4105D6E homoserine dehydrogenase FOC87_04130 ENOG4108Y4K DNA-binding transcriptional activator FOC87_04140 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_04145 ENOG4105BZU Histidine kinase FOC87_04150 ENOG4105DWF phosphomethylpyrimidine kinase FOC87_04155 ENOG4105BZU Histidine kinase FOC87_04160 ENOG4105VCD cytoplasmic protein FOC87_04165 ENOG4105D22 carbon starvation protein FOC87_04170 ENOG4105DY9 regulatoR FOC87_04175 ENOG41079KZ Major Facilitator Superfamily FOC87_04195 ENOG4105EN6 Membrane FOC87_04200 ENOG4106YBV Methyl-accepting chemotaxis FOC87_04210 ENOG4108S4H thioesterase Superfamily protein FOC87_04220 ENOG4105JEU Glycosyl transferase, family 2 FOC87_04225 ENOG4105C5H ABC transporter FOC87_04245 ENOG4105CKK Glycosyl transferase, family 2 FOC87_04250 ENOG41067SE Tetr family transcriptional regulator FOC87_04260 ENOG4105E0X reductase FOC87_04265 ENOG4106F5Q Membrane FOC87_04280 ENOG4105DY9 regulatoR FOC87_04285 ENOG4108HRK Histidine kinase FOC87_04290 ENOG4107RGD Major Facilitator superfamily FOC87_04305 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC87_04315 ENOG4105IW1 AmiS UreI transporter FOC87_04325 ENOG4105CMR udp-glucose 4-epimerase FOC87_04330 ENOG4108UT2 hemolysin iii FOC87_04340 ENOG4105C1J atp-dependent rna helicase FOC87_04355 ENOG4105DPN Oligoendopeptidase f FOC87_04375 ENOG4105C0H protease FOC87_04380 ENOG4105Q2H domain protein FOC87_04395 ENOG4105BZU Histidine kinase FOC87_04400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_04430 ENOG4105CDU Replicative dna helicase FOC87_04440 ENOG4105BZR domain protein FOC87_04445 ENOG4108XMW Membrane FOC87_04455 ENOG4108UUM single-stranded DNA-binding protein FOC87_04465 ENOG4105C3G gtp-binding protein FOC87_04470 ENOG4105VDK protein, conserved in bacteria FOC87_04475 ENOG4105D8X mechanosensitive ion channel FOC87_04480 ENOG4108ZDA Sporulation protein YyaC FOC87_04485 ENOG4105FA0 parb-like partition protein FOC87_04490 ENOG4107QJE Chromosome Partitioning Protein FOC87_04520 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC87_04540 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC87_04545 ENOG410848D S4 domain protein YaaA FOC87_04560 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC87_04595 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC87_04630 ENOG4105ZMH deoxynucleoside kinase FOC87_04640 ENOG4105GTG Isochorismatase FOC87_04645 ENOG4108Z6B deaminase FOC87_04655 ENOG4105C6E dna polymerase iii FOC87_04675 ENOG41067KS pro-sigma K processing FOC87_04710 ENOG4105CXN decarboxylase FOC87_04720 ENOG4105FA2 dna polymerase iii FOC87_04725 ENOG4105MA4 psp1 domain protein FOC87_04735 ENOG41060K3 Methyltransferase FOC87_04745 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC87_04750 ENOG4105KRN Transcriptional regulator, abrb family FOC87_04760 ENOG4105F8V Hydrolase, tatD family FOC87_04765 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC87_04775 ENOG4105XFA sporulation peptidase YabG FOC87_04780 ENOG4105W42 Veg protein FOC87_04795 ENOG4105DFT pur operon repressor FOC87_04800 ENOG4105KME endoribonuclease L-psp FOC87_04830 ENOG4108JA2 transcriptioN-repair coupling factor FOC87_04835 ENOG4108M14 stage v sporulation protein t FOC87_04845 ENOG4108IY2 MazG family FOC87_04850 ENOG41082I2 s4 domain protein FOC87_04855 ENOG4105VYY sporulation protein yabp FOC87_04870 ENOG41060GV RNA binding s1 domain protein FOC87_04895 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC87_04900 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC87_04915 ENOG4105C6T cysteine synthase FOC87_04920 ENOG4105CRQ synthase (Component I) FOC87_04925 ENOG4105DDQ anthranilate synthase FOC87_04930 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC87_04935 ENOG4105EEI dihydropteroate synthase FOC87_04940 ENOG4105KRF dihydroneopterin aldolase FOC87_04945 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC87_04955 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC87_05045 ENOG4108Z0C Uvrb UvrC protein FOC87_05060 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC87_05070 ENOG4105CTP PilT protein domain protein FOC87_05090 ENOG4105D7W serine acetyltransferase FOC87_05105 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC87_05110 ENOG4105M0M Tetracycline resistance protein FOC87_05115 ENOG4105QIV RNA polymerase FOC87_05130 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC87_05155 ENOG4107Y49 methyltransferase FOC87_05170 ENOG4105XPM ribosomal protein FOC87_05300 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC87_05310 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC87_05355 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC87_05385 ENOG4105D1F ATP-binding protein FOC87_05400 ENOG4108NMV polysaccharide deacetylase FOC87_05480 ENOG4105C8B TIGR00159 family FOC87_05485 ENOG4107U5W ybbr family FOC87_05520 ENOG4105CMG Carbohydrate kinase FOC87_05530 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC87_05535 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC87_05575 ENOG4108PSK reductase FOC87_05580 ENOG4108UMI ABC transporter, permease FOC87_05585 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC87_05590 ENOG4105D01 (LipO)protein FOC87_05605 ENOG4105IQ5 FAD linked oxidase domain protein FOC87_05620 ENOG4105C2C drug resistance transporter, Bcr CflA FOC87_05635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC87_05640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC87_05645 ENOG4105C3U ABC transporter FOC87_05650 ENOG4108JQ7 (ABC) transporter FOC87_05675 ENOG4105U5Y Transcriptional regulator FOC87_05685 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC87_05690 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC87_05700 ENOG4105II7 pyrroline-5-carboxylate reductase FOC87_05705 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC87_05715 ENOG4105E0C molybdate abc transporter FOC87_05720 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC87_05725 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC87_05755 ENOG4105F6E Acyl-transferase FOC87_05775 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC87_05785 ENOG4108RE7 deoxyribonuclease FOC87_05795 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC87_05820 ENOG4105C5H ABC transporter FOC87_05835 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC87_05845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC87_05850 ENOG4105C3U ABC transporter FOC87_05855 ENOG4108JQ7 (ABC) transporter FOC87_05860 ENOG410667J hydrolase FOC87_05890 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC87_05895 ENOG4105ERH Fumarylacetoacetate hydrolase FOC87_05905 ENOG4105CUB amino acid FOC87_05910 ENOG4108SC4 )-transporter FOC87_05915 ENOG4105CPF Cell wall formation (By similarity) FOC87_05920 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC87_05935 ENOG4107ZXI Rhomboid family FOC87_05945 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC87_05950 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC87_05960 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC87_06060 ENOG4105K8N protein family UPF0079, ATPase FOC87_06065 ENOG41072GX Peptidase M22 Glycoprotease FOC87_06070 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC87_06080 ENOG4105C5H ABC transporter FOC87_06095 ENOG4108TYN CAAX amino terminal protease family protein FOC87_06110 ENOG4107EV6 Inherit from COG: YD repeat protein FOC87_06130 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC87_06170 ENOG4105C7N Xanthine uracil vitamin C permease FOC87_06180 ENOG4105BZU Histidine kinase FOC87_06205 ENOG4107ZXU DSBA oxidoreductase FOC87_06280 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_06300 ENOG4105SX7 Transporter FOC87_06325 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC87_06330 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC87_06335 ENOG4105C83 adenylosuccinate lyase FOC87_06345 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC87_06370 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC87_06380 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC87_06405 ENOG4105C4R Atp-dependent dna helicase FOC87_06435 ENOG4108W2Y isochorismatase FOC87_06440 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC87_06445 ENOG4108UMI ABC transporter, permease FOC87_06450 ENOG4105D01 (LipO)protein FOC87_06480 ENOG410834F Transcriptional regulator FOC87_06485 ENOG4107I77 yiaA/B two helix domain FOC87_06505 ENOG4105CBD Diacylglycerol kinase FOC87_06510 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC87_06515 ENOG4108JPW Aminotransferase FOC87_06525 ENOG4105C26 Dehydrogenase FOC87_06530 ENOG4105KPY Small multidrug resistance protein FOC87_06550 ENOG4105D9N nucleoside FOC87_06555 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC87_06565 ENOG4105BZU Histidine kinase FOC87_06570 ENOG4108W15 Protein of unknown function (DUF1456) FOC87_06585 ENOG4105DTQ mandelate racemase muconate lactonizing FOC87_06595 ENOG4105DFD Na H antiporter FOC87_06615 ENOG4105D3R alkyl hydroperoxide reductase FOC87_06635 ENOG4105EHG Permease protein FOC87_06640 ENOG4105DQ5 transport system permease protein FOC87_06645 ENOG4108V5C ABC transporter FOC87_06665 ENOG4106UIA FOC87_06670 ENOG4106UIA FOC87_06690 ENOG4105BZU Histidine kinase FOC87_06710 ENOG410756H nucleotidyltransferase FOC87_06715 ENOG4105D2S major facilitator superfamily FOC87_06735 ENOG4105EAB amino acid AbC transporter FOC87_06745 ENOG4105C8Q Methyl-accepting chemotaxis FOC87_06760 ENOG4105DBV ornithine carbamoyltransferase FOC87_06770 ENOG4105C5B carbamate kinase FOC87_06795 ENOG4105CI1 PTS System FOC87_06825 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC87_06840 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC87_06885 ENOG41062JF Transcriptional regulator FOC87_06905 ENOG4105DEU major facilitator superfamily FOC87_06935 ENOG4108N0M stress protein FOC87_06940 ENOG4106FN3 tellurium resistance protein FOC87_06945 ENOG4106FN3 tellurium resistance protein FOC87_06950 ENOG4107TS3 membrane protein, TerC FOC87_06955 ENOG4108TTB tellurium resistance protein FOC87_06975 ENOG4105KJF protein tyrosine phosphatase FOC87_06985 ENOG4107U9T Pfam:Ribonuclease_BN FOC87_06990 ENOG4105C59 p-type ATPase FOC87_06995 ENOG4108IPJ Membrane FOC87_07015 ENOG4107ZTW SNARE associated Golgi FOC87_07030 ENOG410606W general stress protein FOC87_07035 ENOG4105UPD Calcium Proton FOC87_07085 ENOG4108JUB Transcriptional regulator FOC87_07095 ENOG4108IQI permease FOC87_07135 ENOG4108A04 Beta-lactamase FOC87_07150 ENOG4105CKK Glycosyl transferase, family 2 FOC87_07155 ENOG4107QQG Dehydrogenase FOC87_07160 ENOG4105C3I Nad-dependent epimerase dehydratase FOC87_07180 ENOG4105F1A Pyruvate formate-lyase FOC87_07200 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC87_07205 ENOG4105ECP epimerase FOC87_07235 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC87_07240 ENOG4105CEN a g-specific adenine glycosylase FOC87_07245 ENOG4106BXE FOC87_07265 ENOG4105BZ1 (ABC) transporter FOC87_07270 ENOG4107NBY Membrane FOC87_07275 ENOG4105CBC glutamate synthase FOC87_07285 ENOG4108IUW ABC transporter FOC87_07305 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC87_07310 ENOG4105G5W regulator Fur family FOC87_07445 ENOG4105BZ1 (ABC) transporter FOC87_07460 ENOG4108JQC penicillin-binding protein 1A FOC87_07465 ENOG4107ZQN disulfide bond FOC87_07480 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC87_07490 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC87_07500 ENOG4105CYN Serine protein kinase FOC87_07520 ENOG4105C94 Transporter FOC87_07535 ENOG4105DZ6 Band 7 protein FOC87_07545 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC87_07550 ENOG4108V9W transcriptional regulatory protein FOC87_07555 ENOG4105D4T Citrate transporter FOC87_07575 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC87_07580 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC87_07585 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC87_07590 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC87_07595 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC87_07600 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC87_07605 ENOG4108STX response regulator FOC87_07610 ENOG4105US7 Histidine kinase FOC87_07635 ENOG4108MRH transcriptional regulatory protein FOC87_07645 ENOG4105C6K Malic enzyme FOC87_07655 ENOG4108UZ3 Transporter FOC87_07660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC87_07670 ENOG4105BZU Histidine kinase FOC87_07675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_07680 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC87_07685 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC87_07690 ENOG4108JB9 formate dehydrogenase FOC87_07710 ENOG4105CUB amino acid FOC87_07720 ENOG4105C59 p-type ATPase FOC87_07725 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC87_07760 ENOG41073R8 VanW family FOC87_07765 ENOG4108KGH TRANSCRIPTIONal FOC87_07770 ENOG4105D9N nucleoside FOC87_07775 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC87_07780 ENOG4105C37 (CBS) domain FOC87_07785 ENOG4108IJ0 Aspartate ammonia-lyase FOC87_07790 ENOG4105DAA L-lactate FOC87_07805 ENOG4105DUX Transporter FOC87_07810 ENOG4108MES Periplasmic binding protein FOC87_07815 ENOG4105DQ5 transport system permease protein FOC87_07820 ENOG4108IHU transport system permease protein FOC87_07825 ENOG4105E0A ABC, transporter FOC87_07830 ENOG4105DMQ Methyltransferase FOC87_07840 ENOG4105EXW epimerase dehydratase FOC87_07850 ENOG4107T89 von Willebrand factor, type A FOC87_07855 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC87_07860 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC87_07870 ENOG4105BZU Histidine kinase FOC87_07875 ENOG4105D5Q Arginine ornithine antiporter FOC87_07880 ENOG4107414 GntR family transcriptional regulator FOC87_07885 ENOG4105C5Y PTS System FOC87_07890 ENOG4105CG3 alpha amylase, catalytic region FOC87_07905 ENOG4105E1K spore germination protein FOC87_07910 ENOG4108XG2 Histidine kinase FOC87_07915 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_07920 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC87_07935 ENOG4105CRN Aminoglycoside phosphotransferase FOC87_07940 ENOG4105BZG amino acid carrier protein FOC87_07945 ENOG4105CDA abc transporter atp-binding protein FOC87_07950 ENOG4105CT1 (ABC) transporter FOC87_07955 ENOG4105EAD ABC transporter FOC87_07960 ENOG4105DRP amino acid AbC transporter FOC87_07965 ENOG4108IQI permease FOC87_07990 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC87_07995 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC87_08000 ENOG4105BZU Histidine kinase FOC87_08005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_08015 ENOG4105CHH sulfate transporter FOC87_08020 ENOG41068KF Universal stress protein FOC87_08030 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC87_08040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC87_08045 ENOG4108JQ7 (ABC) transporter FOC87_08055 ENOG4105CXY transporter FOC87_08060 ENOG41067TZ transcriptional regulator, MarR family FOC87_08065 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_08070 ENOG4105ETE Transcriptional regulator (LacI family FOC87_08075 ENOG4108RVA ribokinase FOC87_08090 ENOG4105CNN ABC, transporter FOC87_08095 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC87_08160 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC87_08165 ENOG41069ER domain protein FOC87_08170 ENOG4105VZ8 Transcriptional regulator FOC87_08175 ENOG4107D63 FOC87_08185 ENOG4105DUX Transporter FOC87_08205 ENOG4105C85 amino acid FOC87_08210 ENOG4105C7N Xanthine uracil vitamin C permease FOC87_08225 ENOG4105MA6 gCN5-related N-acetyltransferase FOC87_08250 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC87_08255 ENOG4105E2S oxidase) subunit II FOC87_08270 ENOG4106CAD Protein of unknown function (DUF3311) FOC87_08275 ENOG4105E1V na solute symporter FOC87_08290 ENOG4108NHD germination protein FOC87_08295 ENOG4105CE1 Ferrous iron transport protein b FOC87_08300 ENOG4105CE1 Ferrous iron transport protein b FOC87_08305 ENOG4105CE1 Ferrous iron transport protein b FOC87_08310 ENOG4105CVA phosphate FOC87_08315 ENOG4105C8U phosphate abc transporter FOC87_08320 ENOG4105E2Z phosphate ABC transporter (Permease FOC87_08450 ENOG41080XQ Signal transduction protein with cbs domains FOC87_08470 ENOG4105ETU transcriptional activator (TenA FOC87_08480 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC87_08490 ENOG4108VEU Thiamine monophosphate synthase FOC87_08495 ENOG41080HI glycine oxidase FOC87_08510 ENOG4105D06 uba thif-type nad fad binding protein FOC87_08515 ENOG4105DWF phosphomethylpyrimidine kinase FOC87_08565 ENOG4108INS Transcriptional regulator FOC87_08590 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC87_08600 ENOG4105C7N Xanthine uracil vitamin C permease FOC87_08610 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC87_08630 ENOG4105C5Y PTS System FOC87_08665 ENOG4108B31 Spore germination protein FOC87_08685 ENOG4107Y03 Nitroreductase FOC87_08690 ENOG4105ED1 spovr family FOC87_08695 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC87_08700 ENOG4105XTG Pfam:DUF156 FOC87_08705 ENOG4105VFE sira family FOC87_08710 ENOG4107TPS domain protein FOC87_08715 ENOG4105VFE sira family FOC87_08720 ENOG41085GJ domain protein FOC87_08730 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC87_08735 ENOG41087NI Sulfite exporter TauE/SafE FOC87_08745 ENOG4108KGH TRANSCRIPTIONal FOC87_08770 ENOG4105EMD TRANSCRIPTIONal FOC87_08775 ENOG4105VCP PTS System FOC87_08780 ENOG4105VZJ PTS System FOC87_08800 ENOG41069ER domain protein FOC87_08805 ENOG4107RBB ABC transporter, permease FOC87_08810 ENOG4105C19 ABC transporter FOC87_08845 ENOG4105WEF catalase FOC87_08880 ENOG4107T5V SNARE associated Golgi FOC87_08915 ENOG4105CUB amino acid FOC87_08920 ENOG4107RWR Sodium hydrogen exchanger FOC87_08930 ENOG4106KNT transcriptional regulator FOC87_08975 ENOG4108YXU transcriptional regulator AsnC family FOC87_08990 ENOG4105KPY Small multidrug resistance protein FOC87_09005 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC87_09010 ENOG4105E5W Transporter FOC87_09020 ENOG4107RKG DJ-1/PfpI family FOC87_09025 ENOG4105CH6 catalase FOC87_09035 ENOG4105D5Q Arginine ornithine antiporter FOC87_09040 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC87_09050 ENOG4105C26 Dehydrogenase FOC87_09055 ENOG4105BZ1 (ABC) transporter FOC87_09060 ENOG4105BZ1 (ABC) transporter FOC87_09070 ENOG4105DRP amino acid AbC transporter FOC87_09075 ENOG4105CDA abc transporter atp-binding protein FOC87_09090 ENOG410839P FOC87_09125 ENOG4107FQX Alpha-acetolactate decarboxylase FOC87_09140 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC87_09145 ENOG4105D4P Coproporphyrinogen iii oxidase FOC87_09160 ENOG4105CHH sulfate transporter FOC87_09200 ENOG4106AKK s-layer domain-containing protein FOC87_09205 ENOG4106AKK s-layer domain-containing protein FOC87_09215 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC87_09225 ENOG4105CGU Enoyl-CoA hydratase FOC87_09245 ENOG4105DER m42 family FOC87_09265 ENOG4105CTU Proline racemase FOC87_09290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC87_09300 ENOG4108JQ7 (ABC) transporter FOC87_09345 ENOG4105CSH Transporter FOC87_09355 ENOG4108MRH transcriptional regulatory protein FOC87_09415 ENOG4105CDU Replicative dna helicase FOC87_09435 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_09495 ENOG4107P5I polyketide synthase FOC87_09500 ENOG4108IG5 Transcriptional regulator FOC87_09515 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC87_09545 ENOG4105CMT Dihydroxyacetone kinase FOC87_09555 ENOG4105CMT Dihydroxyacetone kinase FOC87_09560 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC87_09565 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC87_09580 ENOG410780I phosphoprotein phosphatase activity FOC87_09590 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC87_09655 ENOG4105WN5 stage II sporulation protein FOC87_09665 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_09675 ENOG4108MJI response regulator FOC87_09680 ENOG4105BZU Histidine kinase FOC87_09685 ENOG4105BZU Histidine kinase FOC87_09725 ENOG4105ENE Histidine kinase FOC87_09730 ENOG4108VB1 regulatoR FOC87_09760 ENOG4107VRP DNA repair exonuclease FOC87_09765 ENOG4106D4I domain protein FOC87_09815 ENOG4108MUZ hydrolase FOC87_09835 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC87_09850 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC87_09870 ENOG4105EMN RNA polymerase sigma factor FOC87_09895 ENOG4105C57 major facilitator superfamily FOC87_09900 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_09910 ENOG4105EEM helicase FOC87_09915 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC87_09940 ENOG4105K59 histidine triad (HIT) protein FOC87_09975 ENOG410905X membrane-flanked domain protein FOC87_09980 ENOG4105CKV Membrane FOC87_10000 ENOG41060BG Tetr family transcriptional regulator FOC87_10020 ENOG410905X membrane-flanked domain protein FOC87_10025 ENOG4105CKV Membrane FOC87_10030 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC87_10035 ENOG4105BZ4 penicillin-binding protein FOC87_10050 ENOG4105C1Q protoporphyrinogen oxidase FOC87_10080 ENOG4105NA0 Transcriptional regulator FOC87_10095 ENOG4105ECB domain protein FOC87_10100 ENOG4105ECB domain protein FOC87_10130 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FOC87_10140 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC87_10150 ENOG4106AXD FOC87_10155 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC87_10160 ENOG4105DF9 Lipoate-protein, ligase FOC87_10170 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_10235 ENOG4105ENX hydrolase FOC87_10240 ENOG4107RN3 metallophosphoesterase FOC87_10250 ENOG4107TVP HD domain protein FOC87_10260 ENOG4108AEY RNA polymerase sigma factor FOC87_10265 ENOG41086D8 Transcriptional regulator FOC87_10275 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_10295 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC87_10320 ENOG4107QP3 malate synthase g FOC87_10350 ENOG4105XVF Competence transcription factor FOC87_10415 ENOG4105ERH Fumarylacetoacetate hydrolase FOC87_10440 ENOG4105CAQ asparagine synthetase FOC87_10445 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC87_10450 ENOG4105CH6 catalase FOC87_10455 ENOG4105BZU Histidine kinase FOC87_10475 ENOG4105QNR S1 RNA binding domain protein FOC87_10485 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC87_10495 ENOG4107AYK membrAne FOC87_10500 ENOG41073B9 FOC87_10510 ENOG4108KP7 hydrolase FOC87_10520 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC87_10545 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC87_10550 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC87_10565 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC87_10580 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC87_10585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC87_10595 ENOG4108JQ7 (ABC) transporter FOC87_10600 ENOG4105UQX Mate efflux family protein FOC87_10620 ENOG4108ZCF integral membrane protein FOC87_10630 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC87_10640 ENOG4105DPN Oligoendopeptidase f FOC87_10655 ENOG4108Z18 K06886 hemoglobin FOC87_10660 ENOG4105MIX Adenylate cyclase FOC87_10680 ENOG4105EMS pseudouridine synthase FOC87_10700 ENOG4105K64 Glycosyl transferase, family 2 FOC87_10720 ENOG4107TVC Glycosyl transferase, family 2 FOC87_10740 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC87_10745 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC87_10755 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC87_10830 ENOG4105CK7 Sodium proline symporter FOC87_10840 ENOG4105DDQ anthranilate synthase FOC87_10935 ENOG4105C7S Dehydrogenase FOC87_10945 ENOG4105VZ8 Transcriptional regulator FOC87_11005 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC87_11020 ENOG4108IUX (ABC) transporter FOC87_11025 ENOG4105RHA ABC transporter, permease FOC87_11070 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC87_11085 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC87_11095 ENOG4105DZ1 carboxypeptidase FOC87_11100 ENOG4105VFR signal peptidase FOC87_11135 ENOG4105C26 Dehydrogenase FOC87_11145 ENOG4105F38 ABC transporter, permease FOC87_11150 ENOG4105D38 putrescine abc transporter FOC87_11155 ENOG4107RUE extracellular solute-binding protein family 1 FOC87_11165 ENOG4105EYF MMPL domain protein FOC87_11175 ENOG4108YBP pseudouridine synthase FOC87_11185 ENOG4105K4I Scp-like extracellular FOC87_11190 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC87_11195 ENOG4105CQB FAD linked oxidase domain protein FOC87_11210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_11215 ENOG4105BZU Histidine kinase FOC87_11220 ENOG4105JXH GntR family transcriptional regulator FOC87_11240 ENOG4106A3R peptidase FOC87_11250 ENOG4108QTI )-transporter FOC87_11255 ENOG4107TS3 membrane protein, TerC FOC87_11260 ENOG4105CZN Potassium uptake protein FOC87_11265 ENOG410681C small acid-soluble spore protein FOC87_11270 ENOG4108Z7G MaoC domain protein dehydratase FOC87_11290 ENOG4105CHR reductase FOC87_11300 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC87_11320 ENOG4105C4Y ABC transporter FOC87_11325 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC87_11330 ENOG4107RCV ABC transporter, permease FOC87_11350 ENOG4105E98 transcriptional regulator DeoR family FOC87_11360 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC87_11370 ENOG4105PXI polysaccharide deacetylase FOC87_11380 ENOG4105BZU Histidine kinase FOC87_11385 ENOG41090MY MarR family Transcriptional regulator FOC87_11395 ENOG4106DF1 FOC87_11400 ENOG4105BZU Histidine kinase FOC87_11410 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC87_11415 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC87_11455 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC87_11460 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC87_11465 ENOG41079K6 HNH endonuclease FOC87_11475 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC87_11480 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC87_11485 ENOG4105CZV ABC transporter FOC87_11495 ENOG4105CJ1 ABC, transporter FOC87_11535 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC87_11540 ENOG4105EA8 2-Nitropropane dioxygenase FOC87_11545 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC87_11555 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC87_11580 ENOG4105NQC Flavodoxin FOC87_11615 ENOG4107QMU Mate efflux family protein FOC87_11620 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC87_11650 ENOG4105CZN Potassium uptake protein FOC87_11655 ENOG41063Y9 FOC87_11660 ENOG4105KBJ sporulation protein ytfj FOC87_11685 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC87_11690 ENOG4105C7K acetolactate synthase FOC87_11695 ENOG4108ZP8 Acetolactate synthase small subunit FOC87_11770 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC87_11780 ENOG4105C5I Dehydrogenase FOC87_11785 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC87_11790 ENOG4105E0M Sulfatase FOC87_11800 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC87_11820 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC87_11825 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC87_11835 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC87_11840 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC87_11845 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC87_11850 ENOG4105C8J )-transporter FOC87_11870 ENOG4105DFD Na H antiporter FOC87_11890 ENOG4105ENE Histidine kinase FOC87_11895 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_11915 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC87_11960 ENOG4105CJ3 phosphate transporter FOC87_11965 ENOG4107GRR phosphate transport regulator FOC87_11970 ENOG4105BZ4 penicillin-binding protein FOC87_11985 ENOG4105BZU Histidine kinase FOC87_11990 ENOG4105I3N Conserved Protein FOC87_12005 ENOG4105BZU Histidine kinase FOC87_12035 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC87_12040 ENOG4105DZ1 carboxypeptidase FOC87_12045 ENOG4108JIC nucleoside recognition domain protein FOC87_12055 ENOG4105FE9 pseudouridine synthase FOC87_12065 ENOG4107TWT Cytochrome c biogenesis protein FOC87_12070 ENOG4105CRE cytochrome C FOC87_12075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_12080 ENOG4105BZU Histidine kinase FOC87_12085 ENOG4108WBT adenosyltransferase FOC87_12090 ENOG41063SB peptidase FOC87_12100 ENOG4108SAX Membrane FOC87_12115 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC87_12120 ENOG4105I7S Abortive infection protein FOC87_12130 ENOG4107RGJ metallophosphoesterase FOC87_12135 ENOG4107X2D transcriptional regulator, merr family FOC87_12140 ENOG4108S6Z Negative regulator of genetic competence FOC87_12165 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC87_12170 ENOG4105HDK L-asparaginase FOC87_12205 ENOG4105S2F FOC87_12210 ENOG41065D1 FOC87_12240 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC87_12255 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC87_12265 ENOG4105EAH synthase FOC87_12285 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC87_12290 ENOG41068YB TPR repeat-containing protein FOC87_12305 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC87_12310 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC87_12315 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC87_12345 ENOG4108JYZ YitT family FOC87_12350 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC87_12365 ENOG4105FJR Lmbe family FOC87_12370 ENOG4105CPK Glycosyl transferase (Group 1 FOC87_12405 ENOG4105DVT helicase FOC87_12410 ENOG4105YAC FOC87_12430 ENOG4105CSM endonuclease III FOC87_12440 ENOG4105BZ4 penicillin-binding protein FOC87_12500 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC87_12510 ENOG4105DVT helicase FOC87_12515 ENOG4105CTD carboxy-peptidase FOC87_12530 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC87_12540 ENOG4105C2W permease FOC87_12545 ENOG4105DHF Membrane FOC87_12550 ENOG410890F Dynamin family FOC87_12560 ENOG4108W0I acetyltransferase FOC87_12570 ENOG4105KHC sulfurtransferase FOC87_12595 ENOG4106032 Glutathionylspermidine synthase FOC87_12625 ENOG4108SZE gCN5-related N-acetyltransferase FOC87_12645 ENOG41081VK Ribonuclease FOC87_12710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC87_12720 ENOG4107RWR Sodium hydrogen exchanger FOC87_12725 ENOG4105CN5 Metallo-Beta-Lactamase FOC87_12730 ENOG4108Z5V transcriptional regulator, merr family FOC87_12740 ENOG4105H67 Protein of unknown function (DUF421) FOC87_12745 ENOG41080C8 DUF218 domain FOC87_12800 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC87_12810 ENOG4107R0U MotA TolQ exbB proton channel FOC87_12815 ENOG4105ER2 Ompa motb domain protein FOC87_12825 ENOG4105CBS Chea signal transduction histidine kinase FOC87_12830 ENOG4105DD5 Flagellar motor switch protein FOC87_12845 ENOG4105BZU Histidine kinase FOC87_12865 ENOG4105E1Q flagellar hook-associated protein FOC87_12870 ENOG4105DTJ flagellar hook-associated protein FOC87_12875 ENOG4107TPX flagellar hook-associated FOC87_12890 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC87_12895 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC87_12905 ENOG4107U2N Flagellar M-ring protein FOC87_12910 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC87_12940 ENOG4105BZE flagellar hook protein, FlgE FOC87_12955 ENOG4107R88 Chemotaxis protein (CheV) FOC87_12965 ENOG4105I03 Flagellin FOC87_12970 ENOG4105I03 Flagellin FOC87_12975 ENOG4105E4C Lytic transglycosylase catalytic FOC87_12985 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC87_12990 ENOG4105DD5 Flagellar motor switch protein FOC87_13000 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC87_13005 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC87_13015 ENOG4105D00 flagellar biosynthetic protein flhB FOC87_13020 ENOG4105D7B Flagellar biosynthesis protein flha FOC87_13025 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC87_13030 ENOG4105KTQ flagellar basal-body rod protein FOC87_13035 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC87_13060 ENOG41062JF Transcriptional regulator FOC87_13090 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC87_13120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC87_13130 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC87_13135 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC87_13175 ENOG4105CVJ phosphoglycerate mutase FOC87_13195 ENOG4105K56 Transcriptional regulator FOC87_13205 ENOG4105CAQ asparagine synthetase FOC87_13225 ENOG4105PGM cation diffusion facilitator family transporter FOC87_13235 ENOG4105DRR Transcriptional regulator, GntR family FOC87_13240 ENOG4108UZ3 Transporter FOC87_13245 ENOG4105CKI cobalamin synthesis protein FOC87_13250 ENOG4108PJD permease FOC87_13265 ENOG4105DFD Na H antiporter FOC87_13270 ENOG4105C9Q fumarate hydratase class II FOC87_13285 ENOG4107QJQ Mate efflux family protein FOC87_13290 ENOG4105EC3 peptidase S51, dipeptidase E FOC87_13310 ENOG4107QIV Cytochrome c biogenesis protein FOC87_13340 ENOG4106BRA Membrane FOC87_13375 ENOG4105CJ1 ABC, transporter FOC87_13395 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC87_13405 ENOG4108IJ0 Aspartate ammonia-lyase FOC87_13410 ENOG4105C6K Malic enzyme FOC87_13445 ENOG41067QW Transcriptional regulator FOC87_13465 ENOG4105FVX FOC87_13500 ENOG4105CSR polyphosphate kinase 2 FOC87_13505 ENOG4105DXI Major Facilitator superfamily FOC87_13520 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC87_13530 ENOG4105EU0 Major facilitator Superfamily FOC87_13535 ENOG4105C6T cysteine synthase FOC87_13555 ENOG4105C8J )-transporter FOC87_13565 ENOG4105X5K response regulator receiver protein FOC87_13570 ENOG4105H67 Protein of unknown function (DUF421) FOC87_13590 ENOG4106KE4 Dehydrogenase FOC87_13605 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC87_13610 ENOG4105CHR reductase FOC87_13615 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC87_13620 ENOG4105C7K acetolactate synthase FOC87_13630 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC87_13640 ENOG4105C7B Threonine dehydratase FOC87_13665 ENOG4105C6X Major Facilitator FOC87_13670 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC87_13690 ENOG4105DY9 regulatoR FOC87_13695 ENOG4105CYC Transferase FOC87_13755 ENOG41068WN FOC87_13760 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_13780 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC87_13795 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC87_13800 ENOG4105C0X amino acid FOC87_13845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_13855 ENOG4107RHR regulatoR FOC87_13865 ENOG4105D9N nucleoside FOC87_13870 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC87_13900 ENOG4107RAQ aminopeptidase FOC87_13905 ENOG4107R16 Multicopper oxidase FOC87_13950 ENOG4108T5E Copper resistance protein FOC87_13955 ENOG4105KTB nuclear export factor GLE1 FOC87_13960 ENOG4107RT3 EamA-like transporter family FOC87_13965 ENOG4105GZI Transcriptional regulator FOC87_13970 ENOG4108Z40 Transcriptional regulator FOC87_13975 ENOG4107ZXU DSBA oxidoreductase FOC87_13980 ENOG4108TVJ Nitroreductase FOC87_13985 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC87_13990 ENOG4106F5Q Membrane FOC87_14005 ENOG4105CKI cobalamin synthesis protein FOC87_14025 ENOG4108Z7G MaoC domain protein dehydratase FOC87_14030 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC87_14040 ENOG4105C0Z ABC transporter FOC87_14045 ENOG4108IV0 ABC, transporter FOC87_14050 ENOG4105C32 Amino acid ABC transporter (Permease) FOC87_14060 ENOG4105EGI Transcriptional regulator FOC87_14090 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC87_14095 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC87_14100 ENOG4108JJ9 ABC, transporter FOC87_14105 ENOG4108JJ8 (ABC) transporter FOC87_14150 ENOG4105BZ1 (ABC) transporter FOC87_14155 ENOG4105EFI regulatoR FOC87_14160 ENOG4105EB3 Histidine kinase FOC87_14180 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC87_14205 ENOG4105D6E homoserine dehydrogenase FOC87_14230 ENOG4108KGH TRANSCRIPTIONal FOC87_14240 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_14245 ENOG4105BZU Histidine kinase FOC87_14260 ENOG4105KT7 mgtC SapB transporter FOC87_14265 ENOG4105VRR gCN5-related N-acetyltransferase FOC87_14275 ENOG4105DUU IucA IucC family protein FOC87_14280 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_14295 ENOG4108WBH protein TIM barrel FOC87_14300 ENOG4105YWU small acid-soluble spore protein FOC87_14310 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC87_14315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC87_14365 ENOG4105KRN Transcriptional regulator, abrb family FOC87_14375 ENOG4105YVS arsR family transcriptional regulator FOC87_14380 ENOG4107SET aldo keto reductase FOC87_14385 ENOG4107XZQ multidrug resistance protein FOC87_14410 ENOG4105C8Q Methyl-accepting chemotaxis FOC87_14425 ENOG4108K88 Membrane FOC87_14430 ENOG4108WPJ Ferritin-like domain FOC87_14445 ENOG4105DEN Luciferase family FOC87_14465 ENOG4107QM2 Aldo Keto reductase FOC87_14470 ENOG4105CKI cobalamin synthesis protein FOC87_14490 ENOG4108IBT Inherit from COG: transposase FOC87_14495 ENOG4105DSE periplasmic solute binding protein FOC87_14505 ENOG4105K4T epimerase FOC87_14515 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC87_14540 ENOG4105CVJ phosphoglycerate mutase FOC87_14560 ENOG4107T5V SNARE associated Golgi FOC87_14575 ENOG4108PJD permease FOC87_14585 ENOG4108S4H thioesterase Superfamily protein FOC87_14595 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC87_14615 ENOG4105SXS Protein of unknown function (DUF456) FOC87_14620 ENOG4105C37 (CBS) domain FOC87_14640 ENOG4108Z7R Chaperone CsaA FOC87_14660 ENOG4108ZRV stage ii sporulation protein p FOC87_14670 ENOG4108VXD carboxy-peptidase FOC87_14700 ENOG4105EFA 4-hydroxyphenylacetate FOC87_14710 ENOG4105U1N riboflavin FOC87_14725 ENOG4105KME endoribonuclease L-psp FOC87_14735 ENOG4105IKQ hydratase FOC87_14755 ENOG41069HH 4-oxalocrotonate tautomerase FOC87_14765 ENOG4108X4Q Hydrolase FOC87_14775 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC87_14795 ENOG41087PP glycosyltransferase MGT family FOC87_14800 ENOG4108JYZ YitT family FOC87_14805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC87_14835 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC87_14915 ENOG4105KBJ sporulation protein ytfj FOC87_14940 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC87_14965 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC87_14975 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC87_14980 ENOG4105EMN RNA polymerase sigma factor FOC87_14995 ENOG4105CNW domain protein FOC87_15005 ENOG4108V06 Glutathione peroxidase FOC87_15020 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC87_15040 ENOG4108IUE nitrate reductase beta subunit FOC87_15045 ENOG4105R3A Nitrate reductase FOC87_15055 ENOG4107V6Q Cyclic nucleotide-binding domain FOC87_15060 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC87_15065 ENOG4105D06 uba thif-type nad fad binding protein FOC87_15075 ENOG4108ZAF Molybdopterin FOC87_15095 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC87_15100 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC87_15105 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC87_15110 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC87_15115 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC87_15120 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC87_15145 ENOG4105MCT stage V sporulation protein S FOC87_15210 ENOG4105C5H ABC transporter FOC87_15225 ENOG4108UUM single-stranded DNA-binding protein FOC87_15255 ENOG4107YX5 Pfam:DUF548 FOC87_15300 ENOG4105C5S asparaginyl-tRNA synthetase FOC87_15320 ENOG4105EC2 ftsk spoIIIe FOC87_15440 ENOG4105BZW Glycerate kinase FOC87_15445 ENOG4107QPK )-transporter FOC87_15450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_15455 ENOG41062D9 Histidine kinase FOC87_15470 ENOG4105C8J )-transporter FOC87_15490 ENOG4107XGZ Hydrolase FOC87_15495 ENOG4105CY2 Citrate transporter FOC87_15500 ENOG4105C0A alcohol dehydrogenase FOC87_15515 ENOG4105KD7 acetyltransferase FOC87_15520 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC87_15545 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC87_15565 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC87_15585 ENOG4107RVG penicillin-binding protein FOC87_15595 ENOG4105E9Q Acyl-transferase FOC87_15600 ENOG4108UT2 hemolysin iii FOC87_15610 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC87_15620 ENOG4108RCR degv family FOC87_15625 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC87_15630 ENOG4108KF3 Electron transport protein SCO1 SenC FOC87_15635 ENOG4107Y70 Heat shock protein FOC87_15640 ENOG4105CAQ asparagine synthetase FOC87_15660 ENOG4108MES Periplasmic binding protein FOC87_15665 ENOG4105F0I Aminotransferase FOC87_15700 ENOG4105D8X mechanosensitive ion channel FOC87_15705 ENOG4105BZU Histidine kinase FOC87_15710 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_15745 ENOG4105CMG Carbohydrate kinase FOC87_15775 ENOG4108IJ8 ABC transporter FOC87_15780 ENOG4105E90 ABC transporter FOC87_15815 ENOG4105C37 (CBS) domain FOC87_15840 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC87_15855 ENOG4107S4Y M20 DapE family protein YgeY FOC87_15860 ENOG4108TSC N-acetyltransferase FOC87_15865 ENOG4108JUB Transcriptional regulator FOC87_15870 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC87_15910 ENOG4108N23 SpoOM-related protein FOC87_15915 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC87_15925 ENOG4105SZ6 Thioredoxin FOC87_15985 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC87_16040 ENOG4105BZ4 penicillin-binding protein FOC87_16050 ENOG4105W8X HesB YadR YfhF-family protein FOC87_16060 ENOG4105DXD 2-methylcitrate dehydratase FOC87_16065 ENOG4105CR4 methylisocitrate lyase FOC87_16070 ENOG4105C1G acyl-Coa dehydrogenase FOC87_16075 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC87_16085 ENOG4105N14 lysine exporter protein LysE YggA FOC87_16090 ENOG4105E39 Enoyl-CoA hydratase FOC87_16105 ENOG4107RFY SbcCD D subunit FOC87_16110 ENOG4105EYH Exonuclease FOC87_16130 ENOG4105FCD Major Facilitator FOC87_16135 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC87_16140 ENOG4105E4F Isochorismate synthase FOC87_16145 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC87_16150 ENOG4105WQI isochorismatase FOC87_16155 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_16160 ENOG4105WQT MbtH domain protein FOC87_16165 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_16180 ENOG4105K70 DNA-binding protein FOC87_16200 ENOG4105BZG amino acid carrier protein FOC87_16220 ENOG4105FE9 pseudouridine synthase FOC87_16225 ENOG4105C22 threonyL-tRNA synthetase FOC87_16235 ENOG4105C19 ABC transporter FOC87_16245 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC87_16270 ENOG4108D32 Methyltransferase FOC87_16300 ENOG41081I9 integral membrane protein FOC87_16315 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC87_16325 ENOG4105EYF MMPL domain protein FOC87_16350 ENOG4105WCN acetyltransferase FOC87_16380 ENOG4105C1Q protoporphyrinogen oxidase FOC87_16390 ENOG41089UC methyltransferase, type 11 FOC87_16395 ENOG41068WN FOC87_16405 ENOG4105VEQ Cold shock protein FOC87_16430 ENOG4107V2S Transcriptional regulator FOC87_16435 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC87_16450 ENOG4105DND Transcriptional regulator FOC87_16455 ENOG4108RPX mosc domain containing protein FOC87_16470 ENOG4105BZ1 (ABC) transporter FOC87_16475 ENOG4105BZ1 (ABC) transporter FOC87_16495 ENOG4108JCI Transcriptional regulator FOC87_16525 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC87_16535 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC87_16540 ENOG4108KPJ rna polymerase sigma factor FOC87_16565 ENOG4105F32 YngK protein FOC87_16590 ENOG4105RD7 BadF BadG BcrA BcrD FOC87_16600 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC87_16635 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC87_16650 ENOG4105C1J atp-dependent rna helicase FOC87_16725 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC87_16750 ENOG41088CC tellurite resistance protein tehB FOC87_16845 ENOG41090HR transcriptional regulator FOC87_16880 ENOG4105CIN aminoacyl-histidine dipeptidase FOC87_16890 ENOG4105EQK -acetyltransferase FOC87_16905 ENOG4107RVG penicillin-binding protein FOC87_16920 ENOG4107RF6 penicillin-binding protein FOC87_16925 ENOG4107RF6 penicillin-binding protein FOC87_16940 ENOG4105ETE Transcriptional regulator (LacI family FOC87_16945 ENOG4105IE8 Alpha-ketoglutarate permease FOC87_16950 ENOG4105CK5 oxidoreductase FOC87_16975 ENOG4105D2N Aldolase FOC87_16980 ENOG4105DH8 myo-inositol catabolism FOC87_17005 ENOG4105CGH 5'-nucleotidase FOC87_17015 ENOG4107JM4 Tetratricopeptide repeat FOC87_17020 ENOG4105VZ8 Transcriptional regulator FOC87_17035 ENOG4108VXD carboxy-peptidase FOC87_17050 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC87_17055 ENOG41067SE Tetr family transcriptional regulator FOC87_17060 ENOG4105C5H ABC transporter FOC87_17090 ENOG4105CEP NADH dehydrogenase FOC87_17095 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC87_17125 ENOG4105C1G acyl-Coa dehydrogenase FOC87_17130 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC87_17135 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC87_17140 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC87_17145 ENOG4105E39 Enoyl-CoA hydratase FOC87_17150 ENOG4107QX3 carboxylase FOC87_17155 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC87_17165 ENOG4105WCN acetyltransferase FOC87_17170 ENOG4105DBI uridine monophosphokinase FOC87_17200 ENOG4105T9C HD domain FOC87_17210 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC87_17250 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC87_17250 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC87_17295 ENOG4105CUV Homoserine Kinase FOC87_17355 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC87_17365 ENOG4105DK7 lysyl-tRNA synthetase FOC87_17450 ENOG4105ETU transcriptional activator (TenA FOC87_17560 ENOG410667J hydrolase FOC87_17565 ENOG4105BZU Histidine kinase FOC87_17570 ENOG4107RF6 penicillin-binding protein FOC87_17605 ENOG4108HGU Histidine kinase FOC87_17615 ENOG4105RHY Pfam:UPF0157 FOC87_17620 ENOG4105CB2 alcohol dehydrogenase FOC87_17625 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC87_17630 ENOG4105CJN penicillin-binding protein FOC87_17635 ENOG4108IG5 Transcriptional regulator FOC87_17640 ENOG4107GJV short-chain dehydrogenase reductase FOC87_17650 ENOG4105FQP Beta-lactamase FOC87_17690 ENOG4108V4B ThiJ pfpI FOC87_17705 ENOG4107Y80 Major Facilitator superfamily FOC87_17720 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC87_17745 ENOG4107Y9U Membrane FOC87_17780 ENOG4105FCD Major Facilitator FOC87_17785 ENOG4105E09 nadh pyrophosphatase FOC87_17790 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC87_17795 ENOG4108Z4K mutator MutT protein FOC87_17815 ENOG4107TB6 phosphoglycerate mutase FOC87_17825 ENOG4108XI2 Domain of unknown function (DUF1963) FOC87_17845 ENOG4108NRW Phospholipase, patatin family FOC87_17850 ENOG4105KWG Pfam:DUF1696 FOC87_17885 ENOG4105PKS Excinuclease abc c subunit domain protein FOC87_17920 ENOG4107VFR oxidoreductase FOC87_17965 ENOG4108IUM Glycogen debranching enzyme FOC87_17990 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC87_17995 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC87_18005 ENOG4105FDR Membrane FOC87_18060 ENOG4105MSI germination protein ypeb FOC87_18095 ENOG4107Z3H Transcriptional regulator, TetR family FOC87_18130 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC87_18145 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC87_18150 ENOG4105E98 transcriptional regulator DeoR family FOC87_18170 ENOG41062ES Transcriptional regulator FOC87_18190 ENOG4107QKR Dehydrogenase FOC87_18200 ENOG4107RUY (E1 component), alpha subunit FOC87_18210 ENOG4105E1F short-chain dehydrogenase reductase FOC87_18215 ENOG4105RHY Pfam:UPF0157 FOC87_18220 ENOG4105DBI uridine monophosphokinase FOC87_18230 ENOG4105M6F mutator MutT protein FOC87_18255 ENOG4107SQ8 Glycine betaine FOC87_18260 ENOG4108IJ7 Glycine betaine FOC87_18285 ENOG4105E66 phosphoriboisomerase A FOC87_18290 ENOG41082BV acetyltransferase FOC87_18295 ENOG4108M1A Chitin-binding protein FOC87_18310 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC87_18315 ENOG4105MSB protein, conserved in bacteria FOC87_18320 ENOG4107YB6 acetyltransferase, (GNAT) family FOC87_18325 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC87_18355 ENOG4108Z7F N-acetyltransferase FOC87_18375 ENOG4105EEM helicase FOC87_18395 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC87_18445 ENOG4108M1A Chitin-binding protein FOC87_18465 ENOG4105BZG amino acid carrier protein FOC87_18470 ENOG4105C26 Dehydrogenase FOC87_18475 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC87_18480 ENOG4105CTU Proline racemase FOC87_18485 ENOG4105CTU Proline racemase FOC87_18490 ENOG41080HI glycine oxidase FOC87_18500 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC87_18530 ENOG4107T5V SNARE associated Golgi FOC87_18545 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC87_18550 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC87_18565 ENOG4105DTQ mandelate racemase muconate lactonizing FOC87_18610 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC87_18615 ENOG4105BZU Histidine kinase FOC87_18620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_18650 ENOG4105DPN Oligoendopeptidase f FOC87_18655 ENOG4105DVH amino acid FOC87_18665 ENOG4105EPR degv family FOC87_18725 ENOG4106K7D Major facilitator family transporter FOC87_18745 ENOG4107BMA Transglycosylase associated protein FOC87_18760 ENOG41089UC methyltransferase, type 11 FOC87_18790 ENOG4105CHM Aminotransferase FOC87_18805 ENOG4108ZMI UPF0477 protein FOC87_18820 ENOG4105DVE abc transporter atp-binding protein FOC87_18865 ENOG4105C02 permease FOC87_18875 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC87_18880 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC87_18885 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC87_18900 ENOG4105E09 nadh pyrophosphatase FOC87_18920 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC87_18990 ENOG4108ZCF integral membrane protein FOC87_18995 ENOG4105E0M Sulfatase FOC87_19000 ENOG4105C5H ABC transporter FOC87_19010 ENOG4105EYF MMPL domain protein FOC87_19015 ENOG41082JN Transcriptional regulator FOC87_19035 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC87_19045 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC87_19065 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC87_19085 ENOG41069ER domain protein FOC87_19095 ENOG4105CY2 Citrate transporter FOC87_19100 ENOG4105E39 Enoyl-CoA hydratase FOC87_19105 ENOG4105J5T Amp-dependent synthetase and ligase FOC87_19110 ENOG4108JUB Transcriptional regulator FOC87_19125 ENOG4105D4B ABC, transporter FOC87_19130 ENOG4105F5R ABC transporter FOC87_19135 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC87_19145 ENOG4105DKT Transcriptional regulator FOC87_19150 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC87_19160 ENOG41061GT Aldolase FOC87_19185 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC87_19220 ENOG4105II7 pyrroline-5-carboxylate reductase FOC87_19230 ENOG4107258 Transcriptional regulator FOC87_19240 ENOG4105E0Y RtcB Protein FOC87_19245 ENOG4105ECK Fatty Acid Desaturase FOC87_19250 ENOG4105G6Z alkaline phosphatase FOC87_19260 ENOG4105VMP Transcriptional regulator FOC87_19275 ENOG41090T1 Membrane FOC87_19285 ENOG4108WCX response regulator FOC87_19295 ENOG41068WN FOC87_19320 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC87_19335 ENOG4105CSH Transporter FOC87_19345 ENOG4105CKK Glycosyl transferase, family 2 FOC87_19360 ENOG4105CKK Glycosyl transferase, family 2 FOC87_19370 ENOG4105C8Y Acetylornithine aminotransferase FOC87_19375 ENOG4105CH6 catalase FOC87_19415 ENOG4108TVJ Nitroreductase FOC87_19420 ENOG4105FS7 Transcriptional regulator FOC87_19455 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC87_19475 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC87_19505 ENOG4108XET gCN5-related N-acetyltransferase FOC87_19565 ENOG410635A Membrane FOC87_19570 ENOG4105KNA -acetyltransferase FOC87_19575 ENOG4108IQI permease FOC87_19585 ENOG4105F1N DNA alkylation repair FOC87_19615 ENOG4107RF6 penicillin-binding protein FOC87_19650 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC87_19655 ENOG4107258 Transcriptional regulator FOC87_19665 ENOG4106N3A copper homeostasis protein cutc FOC87_19670 ENOG4108ZRV stage ii sporulation protein p FOC87_19675 ENOG4108ZHR arsR family transcriptional regulator FOC87_19685 ENOG4105FDT acyl-CoA dehydrogenase FOC87_19700 ENOG4105DWD nucleoside recognition domain protein FOC87_19795 ENOG4105E2A Dehydrogenase FOC87_19805 ENOG4108IJ0 Aspartate ammonia-lyase FOC87_19810 ENOG4105HDK L-asparaginase FOC87_19815 ENOG4108IMY Transcriptional regulator FOC87_19835 ENOG4108B31 Spore germination protein FOC87_19870 ENOG41075H3 AraC family transcriptional regulator FOC87_19890 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC87_19895 ENOG4105CUB amino acid FOC87_19900 ENOG4105II7 pyrroline-5-carboxylate reductase FOC87_19920 ENOG4105CSV Glutaminase FOC87_19955 ENOG4105CGH 5'-nucleotidase FOC87_19960 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC87_20000 ENOG4108606 TspO/MBR family FOC87_20005 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC87_20020 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC87_20025 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC87_20040 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC87_20050 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC87_20055 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC87_20065 ENOG4105C19 ABC transporter FOC87_20080 ENOG4108NEV two component transcriptional regulator, LytTR family FOC87_20085 ENOG4105DSE periplasmic solute binding protein FOC87_20090 ENOG4105CC5 ABC transporter FOC87_20095 ENOG4105DIK (ABC) transporter FOC87_20120 ENOG4105D6J arsenicaL-resistance protein FOC87_20125 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_20130 ENOG41085FC arsR family transcriptional regulator FOC87_20145 ENOG4105F7F Chaperone FOC87_20180 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC87_20185 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_20195 ENOG4105IIP Membrane FOC87_20210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_20215 ENOG41062D9 Histidine kinase FOC87_20240 ENOG4105K6H D-cysteine desulfhydrase FOC87_20265 ENOG4108NNI Beta-lactamase domain-containing protein FOC87_20270 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC87_20280 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC87_20295 ENOG4105C88 aminopeptidase FOC87_20305 ENOG4105W1Y Transcriptional regulator FOC87_20310 ENOG4105JQZ Methyltransferase FOC87_20330 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC87_20345 ENOG4105BZU Histidine kinase FOC87_20360 ENOG4108U05 Transcriptional regulator FOC87_20365 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOC87_20375 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC87_20390 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC87_20405 ENOG4105CEP NADH dehydrogenase FOC87_20410 ENOG4105D4Y metalloprotease FOC87_20415 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC87_20465 ENOG4105TRI Hydrolase FOC87_20505 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC87_20530 ENOG4105C44 Serine transporter FOC87_20535 ENOG4105EJQ L-serine dehydratase FOC87_20545 ENOG4105MZU cell filamentation protein FOC87_20550 ENOG4108JPW Aminotransferase FOC87_20565 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC87_20575 ENOG4105DVH amino acid FOC87_20590 ENOG4108JQ1 Dehydrogenase FOC87_20610 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC87_20615 ENOG410874W AraC family transcriptional regulator FOC87_20630 ENOG4108IBT Inherit from COG: transposase FOC87_20645 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC87_20685 ENOG4108ISG Major Facilitator FOC87_20695 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC87_20700 ENOG4105CZM Major Facilitator FOC87_20715 ENOG4105DA5 (ABC) transporter FOC87_20720 ENOG41069JR FOC87_20730 ENOG4105RXJ FOC87_20740 ENOG4105KBX Transcriptional regulator, TetR family FOC87_20745 ENOG4107AUC FOC87_20755 ENOG4105CRW Short chain fatty acid transporter FOC87_20765 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC87_20800 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC87_20825 ENOG4108K8S endonuclease I FOC87_20830 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC87_20860 ENOG4105DSE periplasmic solute binding protein FOC87_20865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC87_20885 ENOG4108Z66 YbaK ebsC protein FOC87_20895 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_20915 ENOG4105KVH Transcriptional regulator FOC87_20920 ENOG4108RCM Nitroreductase FOC87_20940 ENOG4108PSK reductase FOC87_20950 ENOG4105CJ1 ABC, transporter FOC87_20985 ENOG4105D7V transposase FOC87_21025 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_21030 ENOG4105DKQ ROK family FOC87_21035 ENOG4106UW1 Major Facilitator superfamily FOC87_21040 ENOG4108UW5 maltose o-acetyltransferase FOC87_21065 ENOG4105DMQ Methyltransferase FOC87_21075 ENOG4105EV4 Multidrug resistance protein mdtH FOC87_21105 ENOG4105C37 (CBS) domain FOC87_21120 ENOG4105DDN Pentapeptide repeat-containing protein FOC87_21125 ENOG4105XDF Protein of unknown function (DUF1272) FOC87_21130 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC87_21135 ENOG4105CMG Carbohydrate kinase FOC87_21140 ENOG4105C6Z Gluconate FOC87_21145 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC87_21160 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC87_21180 ENOG4105C44 Serine transporter FOC87_21215 ENOG4108TZY GntR Family Transcriptional Regulator FOC87_21220 ENOG4105D9R oxidoreductase FOC87_21255 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC87_21265 ENOG4105CHR reductase FOC87_21275 ENOG4105KNA -acetyltransferase FOC87_21285 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC87_21290 ENOG4105KVH Transcriptional regulator FOC87_21355 ENOG4105KAF membrAne FOC87_21405 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC87_21420 ENOG4107YXZ hydrolase, family 25 FOC87_21455 ENOG4105H3G oxidoreductase FOC87_21500 ENOG4105K7K Transcriptional regulator FOC87_21505 ENOG4105CIS alcohol dehydrogenase FOC87_21540 ENOG4108TN2 lmbE family FOC87_21550 ENOG4107R3E Citrate transporter FOC87_21565 ENOG4108MES Periplasmic binding protein FOC87_21570 ENOG4105EHG Permease protein FOC87_21575 ENOG4105DQ5 transport system permease protein FOC87_21580 ENOG4105NX3 Membrane FOC87_21585 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC87_21605 ENOG4107V2S Transcriptional regulator FOC87_21625 ENOG4105C98 muts2 protein FOC87_21640 ENOG4105E5K Alpha-amylase FOC87_21645 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC87_21650 ENOG4105DPN Oligoendopeptidase f FOC87_21655 ENOG4108A04 Beta-lactamase FOC87_21685 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC87_21710 ENOG41082BM Transcriptional regulator, arsr family FOC87_21715 ENOG4105CIS alcohol dehydrogenase FOC87_21750 ENOG4105C09 Bile acid FOC87_21755 ENOG4105CQB FAD linked oxidase domain protein FOC87_21775 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC87_21785 ENOG4105K64 Glycosyl transferase, family 2 FOC87_21790 ENOG4105E39 Enoyl-CoA hydratase FOC87_21800 ENOG4105KT7 mgtC SapB transporter FOC87_21815 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_21820 ENOG41073R8 VanW family FOC87_21830 ENOG4108R1P FOC87_21845 ENOG4105VEQ Cold shock protein FOC87_21885 ENOG410904N short-chain dehydrogenase reductase FOC87_21895 ENOG4106IQC argininosuccinate lyase FOC87_21910 ENOG4108IA2 Sodium pantothenate symporter FOC87_21920 ENOG4105C26 Dehydrogenase FOC87_21925 ENOG4105CHR reductase FOC87_21935 ENOG4105EWU Squalene--hopene cyclase FOC87_21945 ENOG4105FR1 rard protein FOC87_21950 ENOG410696E Membrane FOC87_21965 ENOG4105D1F ATP-binding protein FOC87_21975 ENOG4108ZAF Molybdopterin FOC87_21980 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC87_21985 ENOG4105D06 uba thif-type nad fad binding protein FOC87_21990 ENOG4105TMB Formate nitrite transporter FOC87_22000 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC87_22005 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC87_22015 ENOG4108JB9 formate dehydrogenase FOC87_22020 ENOG4105E1K spore germination protein FOC87_22085 ENOG4107QJT sodium dicarboxylate symporter FOC87_22090 ENOG4108KGH TRANSCRIPTIONal FOC87_22100 ENOG4105EMN RNA polymerase sigma factor FOC87_22120 ENOG4105CIG ABC transporter FOC87_22130 ENOG4105D9R oxidoreductase FOC87_22145 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC87_22150 ENOG4105K4P CoA-binding domain protein FOC87_22155 ENOG4105C0H protease FOC87_22160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_22170 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC87_22180 ENOG4105W8X HesB YadR YfhF-family protein FOC87_22210 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC87_22215 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC87_22225 ENOG4108JJA ABC, transporter FOC87_22230 ENOG4108I0Z Aconitate hydratase FOC87_22270 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC87_22290 ENOG4107F3J Amp-dependent synthetase and ligase FOC87_22295 ENOG4107ZYJ bioY protein FOC87_22300 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_22350 ENOG4107AYK membrAne FOC87_22360 ENOG4105BZU Histidine kinase FOC87_22365 ENOG4105FBA Phospholipase Carboxylesterase FOC87_22370 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC87_22375 ENOG4105CK7 Sodium proline symporter FOC87_22380 ENOG4105CBC glutamate synthase FOC87_22385 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC87_22390 ENOG4108VJ1 Transcriptional regulator (CarD family FOC87_22395 ENOG4108903 Formimidoylglutamase FOC87_22420 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC87_22465 ENOG4107QIV Cytochrome c biogenesis protein FOC87_22485 ENOG4105CJ1 ABC, transporter FOC87_22495 ENOG4107RSM transcriptional regulator FOC87_22505 ENOG41067MG lrgb family FOC87_22530 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC87_22545 ENOG4105BZ1 (ABC) transporter FOC87_22550 ENOG4105BZ1 (ABC) transporter FOC87_22590 ENOG4105CGH 5'-nucleotidase FOC87_22600 ENOG4108SVB resolvase FOC87_22620 ENOG4105K7K Transcriptional regulator FOC87_22625 ENOG4105C5F glutamine synthetase FOC87_22630 ENOG4105KV4 Transcriptional regulator FOC87_22635 ENOG4105CXI aluminum resistance protein FOC87_22640 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC87_22645 ENOG4105EN6 Membrane FOC87_22650 ENOG4106F1P AAA ATPase, central domain protein FOC87_22680 ENOG41069ER domain protein FOC87_22685 ENOG4105DM4 PTS System FOC87_22690 ENOG4105DE4 1-phosphofructokinase FOC87_22695 ENOG4105E98 transcriptional regulator DeoR family FOC87_22700 ENOG4107QW4 alcohol dehydrogenase FOC87_22705 ENOG4108SJC Membrane FOC87_22715 ENOG4105C85 amino acid FOC87_22735 ENOG4105TMB Formate nitrite transporter FOC87_22740 ENOG4105K70 DNA-binding protein FOC87_22745 ENOG4105C59 p-type ATPase FOC87_22750 ENOG410681U heavy metal transport detoxification protein FOC87_22755 ENOG4105VPX protein, conserved in bacteria FOC87_22775 ENOG4105NIV Esterase FOC87_22780 ENOG4105E0A ABC, transporter FOC87_22800 ENOG4105CGK Exodeoxyribonuclease III FOC87_22810 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC87_22815 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC87_22845 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_22850 ENOG4105BZU Histidine kinase FOC87_22940 ENOG4105F0V Cell wall hydrolase FOC87_22950 ENOG4105E0M Sulfatase FOC87_22955 ENOG410890F Dynamin family FOC87_22965 ENOG4107QHE Choloylglycine hydrolase FOC87_22995 ENOG4105DQU oxidoreductase, subunit beta FOC87_23000 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC87_23005 ENOG4108IGT Dipeptidase FOC87_23010 ENOG4105MCT stage V sporulation protein S FOC87_23015 ENOG4105D48 metallophosphoesterase FOC87_23035 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC87_23050 ENOG4105XZV Protein of unknown function (DUF3243) FOC87_23055 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC87_23075 ENOG4105UIB (ABC) transporter FOC87_23080 ENOG4108JQ9 ABC transporter FOC87_23085 ENOG4105DIH basic membrane FOC87_23090 ENOG4105FDP GntR family transcriptional regulator FOC87_23095 ENOG4107QZI cell division protein FtsK FOC87_23105 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC87_23115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC87_23125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC87_23130 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC87_23135 ENOG4105E35 Dipicolinate synthase subunit A FOC87_23145 ENOG4105C1V Peptidase, M16 FOC87_23165 ENOG4105DTN riboflavin biosynthesis protein ribF FOC87_23180 ENOG4105W7A Protein of unknown function (DUF503) FOC87_23190 ENOG4105VHM ribosomal protein FOC87_23195 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC87_23200 ENOG4105CHV Transcription elongation factor NusA FOC87_23210 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC87_23215 ENOG4105EKQ RNA-directed DNA polymerase FOC87_23230 ENOG4105DZP Membrane-associated zinc metalloprotease FOC87_23240 ENOG4105KNE Phosphatidate cytidylyltransferase FOC87_23285 ENOG4108HE4 integrase family FOC87_23295 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC87_23300 ENOG4105C79 DNA protecting protein DprA FOC87_23305 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC87_23320 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC87_23345 ENOG4105VB6 UPF0109 protein FOC87_23365 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC87_23370 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC87_23385 ENOG4105CHR reductase FOC87_23390 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC87_23405 ENOG4105CB5 ATP-dependent DNA helicase recG FOC87_23410 ENOG4105DP4 dak2 domain fusion protein ylov FOC87_23415 ENOG4108ZAA Alkaline-shock protein FOC87_23430 ENOG4105FJ0 thiamine FOC87_23435 ENOG4105DJV ribulose-phosphate 3-epimerase FOC87_23440 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC87_23445 ENOG4105D9P serine threonine protein kinase FOC87_23450 ENOG4108ZF3 Phosphatase FOC87_23460 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC87_23470 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC87_23475 ENOG4105C25 Primosomal protein n' FOC87_23480 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC87_23500 ENOG4105DSJ YicC domain protein FOC87_23515 ENOG4105DC7 peptidase M24 FOC87_23605 ENOG4105C34 Pseudouridine synthase FOC87_23630 ENOG4105DBK s4 domain protein FOC87_23635 ENOG41067XK integral membrane protein FOC87_23645 ENOG4105DFA alanine racemase domain protein FOC87_23650 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC87_23655 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC87_23665 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_23675 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC87_23680 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC87_23685 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC87_23690 ENOG4105D4A Cell wall formation (By similarity) FOC87_23700 ENOG4105CNI cell division protein FtsW FOC87_23715 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC87_23720 ENOG4105CJN penicillin-binding protein FOC87_23725 ENOG4105CJN penicillin-binding protein FOC87_23730 ENOG41068DC Essential cell division protein (By similarity) FOC87_23765 ENOG4105KNH Nucleic acid-binding protein FOC87_23775 ENOG41063PX domain protein FOC87_23780 ENOG4105D78 K07001 NTE family protein FOC87_23785 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC87_23795 ENOG4106H78 methyltransferase FOC87_23815 ENOG4107TB6 phosphoglycerate mutase FOC87_23830 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC87_23880 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC87_23885 ENOG4105CNI cell division protein FtsW FOC87_23900 ENOG4108IAB Phoh family FOC87_23920 ENOG4105QA2 FOC87_23925 ENOG4105CI3 gtp-binding protein typa FOC87_23935 ENOG4105ECY inositol monophosphatase FOC87_23955 ENOG4105CXN decarboxylase FOC87_24005 ENOG4105CPP Dehydrogenase, E1 component FOC87_24020 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC87_24025 ENOG4108X4Q Hydrolase FOC87_24035 ENOG4105CN5 Metallo-Beta-Lactamase FOC87_24040 ENOG4107ZYR domain protein FOC87_24075 ENOG4108XRC Protein of unknown function (DUF458) FOC87_24085 ENOG4107IN1 Protein of unknown function (DUF1797) FOC87_24100 ENOG4105EPM Diguanylate phosphodiesterase FOC87_24105 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC87_24120 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC87_24130 ENOG4105UIN FOC87_24185 ENOG4108HGU Histidine kinase FOC87_24195 ENOG4105CHM Aminotransferase FOC87_24200 ENOG4105FKQ transcriptional regulator FOC87_24205 ENOG4105EG2 ABC transporter, permease FOC87_24215 ENOG4107FKK extracellular solute-binding protein family 1 FOC87_24225 ENOG4105CG3 alpha amylase, catalytic region FOC87_24270 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOC87_24275 ENOG4105CHU acetyl-coa acetyltransferase FOC87_24305 ENOG4105K7K Transcriptional regulator FOC87_24310 ENOG4105DTD Dehydrogenase FOC87_24330 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC87_24370 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC87_24375 ENOG4105BZU Histidine kinase FOC87_24395 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC87_24410 ENOG4105CID antiterminator FOC87_24430 ENOG4105CE4 GlcNAc 6-P deacetylase FOC87_24465 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC87_24470 ENOG4105PTM secreted protein FOC87_24475 ENOG4105J7I hydrolase FOC87_24485 ENOG4105G6R Stage v sporulation protein ae FOC87_24495 ENOG4105CZ3 stage V sporulation protein ad FOC87_24500 ENOG41090VF Stage v sporulation protein ac FOC87_24520 ENOG4105C8J )-transporter FOC87_24525 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_24535 ENOG41082AN stage II sporulation protein FOC87_24540 ENOG4105DZ1 carboxypeptidase FOC87_24545 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC87_24550 ENOG4105DVE abc transporter atp-binding protein FOC87_24580 ENOG4105D7N magnesium and cobalt transport protein CorA FOC87_24605 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC87_24615 ENOG4105I3K Ferric uptake regulator, Fur family FOC87_24620 ENOG4105MZ9 stage II sporulation protein m FOC87_24640 ENOG4105CPC Aldo Keto reductase FOC87_24650 ENOG4105RHY Pfam:UPF0157 FOC87_24670 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC87_24680 ENOG4105ETE Transcriptional regulator (LacI family FOC87_24685 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC87_24705 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC87_24710 ENOG4108R6K riboflavin synthase, subunit alpha FOC87_24735 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC87_24740 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC87_24755 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC87_24765 ENOG4105DFD Na H antiporter FOC87_24770 ENOG4105CGH 5'-nucleotidase FOC87_24810 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC87_24825 ENOG4108IXY short-chain dehydrogenase reductase FOC87_24830 ENOG41069FQ Metallo-beta-lactamase superfamily FOC87_24835 ENOG4105II7 pyrroline-5-carboxylate reductase FOC87_24840 ENOG4105EJQ L-serine dehydratase FOC87_24865 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC87_24875 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC87_24880 ENOG4105D9U N-acetyltransferase FOC87_24895 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC87_24900 ENOG4108QEG Membrane FOC87_24905 ENOG4105CDA abc transporter atp-binding protein FOC87_24910 ENOG4105E5Q amino acid AbC transporter FOC87_24915 ENOG4108HW3 (ABC) transporter FOC87_24925 ENOG4105G7B Protein of unknown function (DUF2992) FOC87_24930 ENOG4105E09 nadh pyrophosphatase FOC87_24940 ENOG4105C7S Dehydrogenase FOC87_24945 ENOG4105CPP Dehydrogenase, E1 component FOC87_24965 ENOG4107RDP Dehydrogenase FOC87_24975 ENOG4108JUB Transcriptional regulator FOC87_24985 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC87_25000 ENOG4107QQR Sporulation FOC87_25005 ENOG4105S1Z Stage IV sporulation protein B FOC87_25010 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC87_25020 ENOG4105DX0 Hemolysin A FOC87_25030 ENOG4105CTB Polyprenyl synthetase FOC87_25055 ENOG4108ZSR alkaline shock protein FOC87_25060 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC87_25085 ENOG410644B Stage III sporulation protein af FOC87_25095 ENOG4105KQ4 Stage iii sporulation protein ad FOC87_25100 ENOG4108CQH stage III sporulation protein AC FOC87_25105 ENOG4105KR5 Stage iii sporulation protein FOC87_25110 ENOG4105CD2 stage iii sporulation protein aa FOC87_25135 ENOG4105DC7 peptidase M24 FOC87_25150 ENOG4105CBJ Metal-dependent enzyme FOC87_25160 ENOG4107YBY Hydrolase FOC87_25175 ENOG4105K7K Transcriptional regulator FOC87_25190 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC87_25195 ENOG4105WZW rhodanese family FOC87_25215 ENOG41080TC multidrug resistance protein FOC87_25250 ENOG4105CJ1 ABC, transporter FOC87_25255 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC87_25285 ENOG4105C0D helicase FOC87_25405 ENOG4105C3R Methionine synthase FOC87_25415 ENOG4105C28 cystathionine FOC87_25420 ENOG4105C28 cystathionine FOC87_25440 ENOG4105C5X domain protein FOC87_25450 ENOG4105DKQ ROK family FOC87_25460 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC87_25475 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC87_25485 ENOG4105E2Z phosphate ABC transporter (Permease FOC87_25490 ENOG4105C8U phosphate abc transporter FOC87_25495 ENOG4105PWN phosphate abc transporter FOC87_25500 ENOG4107RF6 penicillin-binding protein FOC87_25510 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC87_25535 ENOG4105N80 Ferric uptake regulator, Fur family FOC87_25545 ENOG4105FDK ABC transporter FOC87_25550 ENOG4108JYZ YitT family FOC87_25555 ENOG41069ZM Protein of unknown function (DUF2624) FOC87_25580 ENOG4105EGD dinuclear metal center protein, YbgI family FOC87_25595 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_25600 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC87_25630 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC87_25635 ENOG4105KG3 cytidine deaminase FOC87_25640 ENOG4107YR5 Diacylglycerol kinase FOC87_25650 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC87_25655 ENOG4105C9A Phoh family FOC87_25665 ENOG41068P3 sporulation protein YqfC FOC87_25670 ENOG4105KTH gatB Yqey FOC87_25680 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC87_25685 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC87_25715 ENOG4105CSA Coproporphyrinogen iii oxidase FOC87_25720 ENOG4105KVH Transcriptional regulator FOC87_25745 ENOG4105TQK DNA polymerase iii, delta' subunit FOC87_25755 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC87_25760 ENOG4108UK2 deaminase FOC87_25765 ENOG4105KQC Competence protein FOC87_25775 ENOG4105DXX methyltransferase FOC87_25785 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC87_25795 ENOG410812S Rna-binding protein FOC87_25805 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC87_25810 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC87_25825 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_25855 ENOG4108TVJ Nitroreductase FOC87_25870 ENOG4105G6Z alkaline phosphatase FOC87_25880 ENOG4108MUZ hydrolase FOC87_25915 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC87_25920 ENOG4105MIR Phenylalanine 4-monooxygenase FOC87_25930 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_25970 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC87_25975 ENOG4108V5C ABC transporter FOC87_25985 ENOG4105C0A alcohol dehydrogenase FOC87_25990 ENOG4105C28 cystathionine FOC87_26020 ENOG4107XRG penicillin-binding protein FOC87_26035 ENOG4105CFP Peptidase U32 FOC87_26040 ENOG4105XYU peptidase (U32 family) FOC87_26050 ENOG4105HHA aminodeoxychorismate lyase FOC87_26080 ENOG4105C02 permease FOC87_26095 ENOG41060CR FOC87_26100 ENOG4105C7H Helicase, RecD TraA family FOC87_26115 ENOG4105C3J Cysteine desulfurase FOC87_26125 ENOG4105D1H recombination factor protein RarA FOC87_26130 ENOG4108VCI transcription factor, rsfa family FOC87_26135 ENOG4105CUZ uba thif-type nad fad binding protein FOC87_26160 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC87_26170 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC87_26175 ENOG41076HS cation diffusion facilitator family transporter FOC87_26180 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC87_26190 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC87_26195 ENOG4108QG2 Membrane FOC87_26205 ENOG4105VIE preprotein translocase, subunit YajC FOC87_26220 ENOG41061AI Protein of unknown function (DUF2905) FOC87_26235 ENOG4108HUF Transporter FOC87_26245 ENOG4108IPJ Membrane FOC87_26250 ENOG41082BM Transcriptional regulator, arsr family FOC87_26275 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC87_26280 ENOG4108IYU L-aspartate oxidase FOC87_26295 ENOG4108RPX mosc domain containing protein FOC87_26300 ENOG4105CQC Prephenate dehydratase FOC87_26320 ENOG4105EWM Histidine kinase FOC87_26345 ENOG4105X36 (ribosomal) protein FOC87_26355 ENOG4105C03 ribonuclease FOC87_26370 ENOG4107QMS site-determining protein FOC87_26390 ENOG4105DFF Rod shape-determining protein mreb FOC87_26470 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC87_26485 ENOG41068KH stage VI sporulation protein D FOC87_26495 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC87_26520 ENOG4105K56 Transcriptional regulator FOC87_26540 ENOG4108IUQ atp-dependent protease FOC87_26570 ENOG4108QCI YvbH-like oligomerisation region FOC87_26585 ENOG4105M59 Phosphodiesterase, mj0936 family FOC87_26600 ENOG4108XJQ germination protein FOC87_26610 ENOG4108PCX Major Facilitator FOC87_26620 ENOG4105KBX Transcriptional regulator, TetR family FOC87_26635 ENOG4105PFC Transcriptional regulator FOC87_26645 ENOG4105DZC cytosine deaminase FOC87_26650 ENOG41067S9 phage shock protein C, PspC FOC87_26655 ENOG4108JCI Transcriptional regulator FOC87_26665 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC87_26670 ENOG4108Z40 Transcriptional regulator FOC87_26675 ENOG4105RHA ABC transporter, permease FOC87_26680 ENOG4108IUX (ABC) transporter FOC87_26685 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC87_26690 ENOG4105ER2 Ompa motb domain protein FOC87_26695 ENOG4105E14 MotA TolQ exbB proton channel FOC87_26700 ENOG4108VXD carboxy-peptidase FOC87_26710 ENOG4105E33 succinate dehydrogenase FOC87_26720 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC87_26735 ENOG4105K63 Thioredoxin FOC87_26740 ENOG4105C10 Electron transfer flavoprotein FOC87_26745 ENOG4105BZJ Electron transfer flavoprotein FOC87_26750 ENOG41060WC Enoyl-CoA hydratase FOC87_26755 ENOG4107Z3H Transcriptional regulator, TetR family FOC87_26760 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_26770 ENOG4105J76 Periplasmic binding protein FOC87_26775 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC87_26815 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_26830 ENOG4105DR4 Methyltransferase FOC87_26845 ENOG4105KFN sortase, SrtB family FOC87_26850 ENOG4105E0A ABC, transporter FOC87_26865 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC87_26870 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC87_26880 ENOG4105FE9 pseudouridine synthase FOC87_26890 ENOG4105DCG PHP domain protein FOC87_26940 ENOG4108RWN rrna methyltransferase FOC87_26985 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_26990 ENOG4105CW7 secretion protein, HlyD family FOC87_26995 ENOG4108JGH Tetr family transcriptional regulator FOC87_27000 ENOG4105CN9 Peptidase m42 family protein FOC87_27025 ENOG4105C22 threonyL-tRNA synthetase FOC87_27030 ENOG4108TDW sporulation protein YtxC FOC87_27055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC87_27140 ENOG41060SN FOC87_27170 ENOG4106CGH Phage Mu protein F like protein FOC87_27175 ENOG4108MDF Phage Portal Protein FOC87_27185 ENOG4108TFU terminase (Small subunit) FOC87_27190 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC87_27215 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC87_27290 ENOG4106CVF DNA replication protein FOC87_27320 ENOG4105WXW Antirepressor FOC87_27385 ENOG4107QJE Chromosome Partitioning Protein