locus-tag class description FOC88_00115 ENOG4108MDF Phage Portal Protein FOC88_00120 ENOG4106CGH Phage Mu protein F like protein FOC88_00150 ENOG41060SN FOC88_00230 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC88_00255 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC88_00275 ENOG4107QJE Chromosome Partitioning Protein FOC88_00355 ENOG4108IMY Transcriptional regulator FOC88_00405 ENOG4106CVF DNA replication protein FOC88_00440 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC88_00460 ENOG4107R8N Glycosyl transferase, family 2 FOC88_00485 ENOG4105E0M Sulfatase FOC88_00495 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC88_00505 ENOG4105DAA L-lactate FOC88_00540 ENOG4107RSM transcriptional regulator FOC88_00545 ENOG4105ECB domain protein FOC88_00550 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC88_00565 ENOG4105VZJ PTS System FOC88_00575 ENOG4105VCP PTS System FOC88_00580 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC88_00585 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC88_00595 ENOG4105CK1 PTS System FOC88_00600 ENOG4105VCP PTS System FOC88_00605 ENOG4105F8D glycoside hydrolase family 4 FOC88_00625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC88_00635 ENOG4105ESV Glycosyl transferase, family 4 FOC88_00640 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC88_00645 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC88_00650 ENOG4108KGH TRANSCRIPTIONal FOC88_00655 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC88_00665 ENOG4105KVH Transcriptional regulator FOC88_00680 ENOG41081UC Inherit from COG: Competence protein FOC88_00685 ENOG4105VEQ Cold shock protein FOC88_00690 ENOG4105MS2 ribosomal subunit Interface protein FOC88_00710 ENOG4105CAK Cell division ATP-binding protein ftsE FOC88_00715 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC88_00720 ENOG4105CN1 protease FOC88_00730 ENOG4105BZ1 (ABC) transporter FOC88_00745 ENOG4108WS4 fmn reductase FOC88_00755 ENOG4105DUM transcriptional regulator, lysR family FOC88_00760 ENOG4105HMI Membrane FOC88_00790 ENOG4107TXC Transcriptional regulator FOC88_00810 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC88_00820 ENOG41086DT Membrane protein of unknown function FOC88_00840 ENOG4108S4C acetyltransferase FOC88_00850 ENOG4105C3M thioredoxin reductase FOC88_00860 ENOG4108Z4K mutator MutT protein FOC88_00870 ENOG4105CHW UPF0052 protein FOC88_00880 ENOG4105KRI phosphocarrier protein (HPr FOC88_00890 ENOG4105H67 Protein of unknown function (DUF421) FOC88_00905 ENOG4105CZ3 stage V sporulation protein ad FOC88_00910 ENOG41090VF Stage v sporulation protein ac FOC88_00930 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_00980 ENOG41067MG lrgb family FOC88_00985 ENOG4105XZU Preprotein translocase, subunit SecG FOC88_00995 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC88_01015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_01030 ENOG4105CM4 permease protein FOC88_01035 ENOG4108IPW abc transporter atp-binding protein FOC88_01055 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC88_01085 ENOG4105C8Q Methyl-accepting chemotaxis FOC88_01110 ENOG4105D4A Cell wall formation (By similarity) FOC88_01115 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC88_01130 ENOG4105KVH Transcriptional regulator FOC88_01135 ENOG4105F27 Major Facilitator FOC88_01140 ENOG4105CV8 reductase FOC88_01160 ENOG4108RYK Nad-dependent epimerase dehydratase FOC88_01170 ENOG4105D9N nucleoside FOC88_01175 ENOG4105D9N nucleoside FOC88_01195 ENOG4108URH decarboxylase FOC88_01210 ENOG4108RMU ferritin dps family protein FOC88_01220 ENOG4105NCW Trka-c domain protein FOC88_01225 ENOG4107S91 Sodium hydrogen exchanger FOC88_01245 ENOG4105D4Y metalloprotease FOC88_01250 ENOG4105VG1 fes assembly suf system protein FOC88_01255 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC88_01260 ENOG4105C8Q Methyl-accepting chemotaxis FOC88_01280 ENOG4105BZU Histidine kinase FOC88_01285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_01290 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC88_01300 ENOG4107ZTW SNARE associated Golgi FOC88_01335 ENOG4107AYK membrAne FOC88_01345 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC88_01355 ENOG4107R7I amino acid FOC88_01360 ENOG4108SUT Major Facilitator Superfamily FOC88_01380 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC88_01400 ENOG4105DZ1 carboxypeptidase FOC88_01415 ENOG4105CHU acetyl-coa acetyltransferase FOC88_01425 ENOG4105C1G acyl-Coa dehydrogenase FOC88_01430 ENOG4108W8B Beta-lactamase domain protein FOC88_01440 ENOG4108IMY Transcriptional regulator FOC88_01510 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC88_01540 ENOG4108UMI ABC transporter, permease FOC88_01545 ENOG4105D01 (LipO)protein FOC88_01550 ENOG4105D01 (LipO)protein FOC88_01555 ENOG4105C3K feS assembly ATPase SufC FOC88_01560 ENOG4105JRK feS assembly protein SufD FOC88_01565 ENOG4105C9B Cysteine desulfurase FOC88_01570 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC88_01575 ENOG4105DIW FeS assembly protein SUFB FOC88_01580 ENOG4107R8B 5'-nucleotidase FOC88_01585 ENOG4105KZD Domain of unknown function (DUF1805) FOC88_01595 ENOG4105FAA peptidase M23 FOC88_01620 ENOG41090T1 Membrane FOC88_01625 ENOG4107TXC Transcriptional regulator FOC88_01630 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC88_01635 ENOG4105MMD transcriptional regulator FOC88_01650 ENOG4105CBT Fructose-1,6-bisphosphatase FOC88_01665 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC88_01675 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC88_01685 ENOG4108W5N phosphatidylglycerophosphatase a FOC88_01700 ENOG41083MR nifu domain-containing protein FOC88_01725 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC88_01730 ENOG4105C4B ABC transporter, permease FOC88_01735 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC88_01760 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC88_01770 ENOG4105EWC Purine nucleoside phosphorylase FOC88_01800 ENOG4105CEP NADH dehydrogenase FOC88_01820 ENOG41069ER domain protein FOC88_01840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC88_01860 ENOG4105KA0 thioesterase Superfamily protein FOC88_01880 ENOG4107R3E Citrate transporter FOC88_01890 ENOG4105Y38 Kinase-associated protein B FOC88_01905 ENOG4105C87 Aminotransferase class I and II FOC88_01915 ENOG4108MUZ hydrolase FOC88_01920 ENOG4105C5I Dehydrogenase FOC88_01925 ENOG4108ZB6 transcriptional regulator AsnC family FOC88_01930 ENOG4105CHM Aminotransferase FOC88_01940 ENOG4105WG9 Conserved Protein FOC88_01955 ENOG4107PBV potassium channel FOC88_01960 ENOG4105KT7 mgtC SapB transporter FOC88_01995 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC88_02090 ENOG4105JVQ RNA Polymerase FOC88_02150 ENOG4105VEQ Cold shock protein FOC88_02160 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC88_02165 ENOG4105E4F Isochorismate synthase FOC88_02170 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC88_02175 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC88_02180 ENOG4108IPT Naphthoate synthase FOC88_02190 ENOG4105DTQ mandelate racemase muconate lactonizing FOC88_02220 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC88_02285 ENOG41086D8 Transcriptional regulator FOC88_02290 ENOG4105C19 ABC transporter FOC88_02305 ENOG4107ZTW SNARE associated Golgi FOC88_02330 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC88_02335 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC88_02360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_02365 ENOG4105BZU Histidine kinase FOC88_02395 ENOG41087YS Phage shock protein A FOC88_02440 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC88_02445 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC88_02450 ENOG4108V2W Carbonate dehydratase FOC88_02510 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC88_02520 ENOG4105D2X ABC transporter substrate-binding protein FOC88_02535 ENOG4107T7U Sulfatase FOC88_02540 ENOG4107S9D Alpha beta hydrolase FOC88_02545 ENOG4105BZU Histidine kinase FOC88_02550 ENOG4105BZU Histidine kinase FOC88_02555 ENOG4105EGD dinuclear metal center protein, YbgI family FOC88_02610 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC88_02620 ENOG4105BZF Glycosyl transferase (Group 1 FOC88_02625 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC88_02630 ENOG4108Z0R Transferase FOC88_02635 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC88_02665 ENOG4105CIG ABC transporter FOC88_02675 ENOG4105N5T Radical SAM Protein FOC88_02695 ENOG4105C19 ABC transporter FOC88_02710 ENOG4105NCW Trka-c domain protein FOC88_02715 ENOG4107S91 Sodium hydrogen exchanger FOC88_02720 ENOG410605W Major Facilitator FOC88_02750 ENOG4108B31 Spore germination protein FOC88_02760 ENOG4105DWV Homoserine O-trans-acetylase FOC88_02770 ENOG41085GJ domain protein FOC88_02790 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC88_02795 ENOG4105D06 uba thif-type nad fad binding protein FOC88_02805 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC88_02810 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC88_02815 ENOG4108ZAF Molybdopterin FOC88_02835 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC88_02840 ENOG4108VJ1 Transcriptional regulator (CarD family FOC88_02875 ENOG4105CBX hi0933 family FOC88_02890 ENOG4105YW5 deoR family transcriptional regulator FOC88_02895 ENOG4107QSE Dipeptidase FOC88_02905 ENOG4108IUM Glycogen debranching enzyme FOC88_02910 ENOG4108V15 phosphotransferase enzyme family FOC88_02925 ENOG4105C8F Beta-lactamase domain protein FOC88_02955 ENOG4108VDD TRNA binding domain protein FOC88_02985 ENOG4105K7K Transcriptional regulator FOC88_03015 ENOG4105C88 aminopeptidase FOC88_03035 ENOG4105ETE Transcriptional regulator (LacI family FOC88_03065 ENOG4105EP9 oxidoreductase FOC88_03070 ENOG4107SNB ankyrin repeat protein YahD FOC88_03080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_03090 ENOG4106HB6 Alpha beta hydrolase FOC88_03095 ENOG4105DGU Histone deacetylase FOC88_03100 ENOG4105W87 Cbs domain FOC88_03105 ENOG4105F1V Acetoin utilization protein FOC88_03120 ENOG4105EMN RNA polymerase sigma factor FOC88_03150 ENOG4105C28 cystathionine FOC88_03160 ENOG4105U5Y Transcriptional regulator FOC88_03170 ENOG4106KR7 LysR family Transcriptional regulator FOC88_03195 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC88_03205 ENOG4105EFZ amidohydrolase FOC88_03220 ENOG4105KBJ sporulation protein ytfj FOC88_03225 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC88_03255 ENOG4108JYZ YitT family FOC88_03295 ENOG4107YZX Universal stress protein FOC88_03315 ENOG4105VZ8 Transcriptional regulator FOC88_03325 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC88_03370 ENOG4105DC7 peptidase M24 FOC88_03410 ENOG4105SFS phosphoesterase RecJ domain protein FOC88_03420 ENOG4105VV2 FOC88_03425 ENOG4105C0B DNA polymerase III (alpha subunit) FOC88_03430 ENOG4105C6K Malic enzyme FOC88_03435 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC88_03460 ENOG4105FS0 cytoplasmic membrane protein FOC88_03465 ENOG4108REF Sporulation integral membrane protein ytvi FOC88_03475 ENOG4105BZN citrate synthase FOC88_03480 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC88_03500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_03505 ENOG4105BZU Histidine kinase FOC88_03510 ENOG4105C2M dna polymerase I FOC88_03525 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC88_03530 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC88_03555 ENOG4108TDW sporulation protein YtxC FOC88_03560 ENOG4105C22 threonyL-tRNA synthetase FOC88_03585 ENOG4105CN9 Peptidase m42 family protein FOC88_03590 ENOG4108JGH Tetr family transcriptional regulator FOC88_03595 ENOG4105CW7 secretion protein, HlyD family FOC88_03600 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_03635 ENOG4108RWN rrna methyltransferase FOC88_03685 ENOG4105DCG PHP domain protein FOC88_03695 ENOG4105FE9 pseudouridine synthase FOC88_03705 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC88_03710 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC88_03725 ENOG4105E0A ABC, transporter FOC88_03730 ENOG4105KFN sortase, SrtB family FOC88_03745 ENOG4105DR4 Methyltransferase FOC88_03760 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_03800 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC88_03805 ENOG4105J76 Periplasmic binding protein FOC88_03815 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_03820 ENOG4107Z3H Transcriptional regulator, TetR family FOC88_03825 ENOG41060WC Enoyl-CoA hydratase FOC88_03830 ENOG4105BZJ Electron transfer flavoprotein FOC88_03835 ENOG4105C10 Electron transfer flavoprotein FOC88_03840 ENOG4105K63 Thioredoxin FOC88_03855 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC88_03865 ENOG4105E33 succinate dehydrogenase FOC88_03875 ENOG4108VXD carboxy-peptidase FOC88_03880 ENOG4105E14 MotA TolQ exbB proton channel FOC88_03885 ENOG4105ER2 Ompa motb domain protein FOC88_03890 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC88_03895 ENOG4108IUX (ABC) transporter FOC88_03900 ENOG4105RHA ABC transporter, permease FOC88_03905 ENOG4108Z40 Transcriptional regulator FOC88_03910 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC88_03920 ENOG4108JCI Transcriptional regulator FOC88_03925 ENOG41067S9 phage shock protein C, PspC FOC88_03945 ENOG4105DY9 regulatoR FOC88_03950 ENOG4108HRK Histidine kinase FOC88_03955 ENOG4108JQ7 (ABC) transporter FOC88_03970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_03975 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC88_03980 ENOG4105DZC cytosine deaminase FOC88_03985 ENOG4105DZC cytosine deaminase FOC88_04000 ENOG4105PFC Transcriptional regulator FOC88_04015 ENOG4105KBX Transcriptional regulator, TetR family FOC88_04025 ENOG4108PCX Major Facilitator FOC88_04035 ENOG4108XJQ germination protein FOC88_04050 ENOG4105M59 Phosphodiesterase, mj0936 family FOC88_04070 ENOG4108QCI YvbH-like oligomerisation region FOC88_04100 ENOG4108IUQ atp-dependent protease FOC88_04120 ENOG4105K56 Transcriptional regulator FOC88_04145 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC88_04155 ENOG41068KH stage VI sporulation protein D FOC88_04165 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC88_04170 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC88_04190 ENOG4105DFF Rod shape-determining protein mreb FOC88_04210 ENOG4107QMS site-determining protein FOC88_04225 ENOG4105C03 ribonuclease FOC88_04235 ENOG4105X36 (ribosomal) protein FOC88_04260 ENOG4105EWM Histidine kinase FOC88_04280 ENOG4105CQC Prephenate dehydratase FOC88_04285 ENOG4108RPX mosc domain containing protein FOC88_04300 ENOG4108IYU L-aspartate oxidase FOC88_04305 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC88_04330 ENOG41082BM Transcriptional regulator, arsr family FOC88_04335 ENOG4108IPJ Membrane FOC88_04345 ENOG4108HUF Transporter FOC88_04360 ENOG41061AI Protein of unknown function (DUF2905) FOC88_04375 ENOG4105VIE preprotein translocase, subunit YajC FOC88_04385 ENOG4108QG2 Membrane FOC88_04390 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC88_04400 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC88_04405 ENOG41076HS cation diffusion facilitator family transporter FOC88_04410 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC88_04420 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC88_04445 ENOG4105CUZ uba thif-type nad fad binding protein FOC88_04450 ENOG4108VCI transcription factor, rsfa family FOC88_04455 ENOG4105D1H recombination factor protein RarA FOC88_04465 ENOG4105C3J Cysteine desulfurase FOC88_04480 ENOG4105C7H Helicase, RecD TraA family FOC88_04485 ENOG41060CR FOC88_04500 ENOG4105C02 permease FOC88_04530 ENOG4105HHA aminodeoxychorismate lyase FOC88_04540 ENOG4105XYU peptidase (U32 family) FOC88_04545 ENOG4105CFP Peptidase U32 FOC88_04560 ENOG4107XRG penicillin-binding protein FOC88_04590 ENOG4105C28 cystathionine FOC88_04595 ENOG4105C0A alcohol dehydrogenase FOC88_04605 ENOG4108V5C ABC transporter FOC88_04610 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC88_04650 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_04660 ENOG4105MIR Phenylalanine 4-monooxygenase FOC88_04665 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC88_04700 ENOG4108MUZ hydrolase FOC88_04710 ENOG4105G6Z alkaline phosphatase FOC88_04725 ENOG4108TVJ Nitroreductase FOC88_04745 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_04760 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC88_04765 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC88_04775 ENOG410812S Rna-binding protein FOC88_04785 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC88_04795 ENOG4105DXX methyltransferase FOC88_04805 ENOG4105KQC Competence protein FOC88_04810 ENOG4108UK2 deaminase FOC88_04815 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC88_04825 ENOG4105TQK DNA polymerase iii, delta' subunit FOC88_04850 ENOG4105KVH Transcriptional regulator FOC88_04855 ENOG4105CSA Coproporphyrinogen iii oxidase FOC88_04885 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC88_04890 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC88_04900 ENOG4105KTH gatB Yqey FOC88_04905 ENOG41068P3 sporulation protein YqfC FOC88_04915 ENOG4105C9A Phoh family FOC88_04920 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC88_04930 ENOG4107YR5 Diacylglycerol kinase FOC88_04935 ENOG4105KG3 cytidine deaminase FOC88_04940 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC88_04970 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC88_04975 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_04990 ENOG4105EGD dinuclear metal center protein, YbgI family FOC88_05015 ENOG41069ZM Protein of unknown function (DUF2624) FOC88_05020 ENOG4108JYZ YitT family FOC88_05025 ENOG4105FDK ABC transporter FOC88_05035 ENOG4105N80 Ferric uptake regulator, Fur family FOC88_05060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC88_05070 ENOG4107RF6 penicillin-binding protein FOC88_05075 ENOG4105PWN phosphate abc transporter FOC88_05080 ENOG4105C8U phosphate abc transporter FOC88_05085 ENOG4105E2Z phosphate ABC transporter (Permease FOC88_05095 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC88_05110 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC88_05120 ENOG4105DKQ ROK family FOC88_05130 ENOG4105C5X domain protein FOC88_05150 ENOG4105C28 cystathionine FOC88_05155 ENOG4105C28 cystathionine FOC88_05165 ENOG4105C3R Methionine synthase FOC88_05170 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC88_05285 ENOG4105C0D helicase FOC88_05315 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC88_05355 ENOG41080TC multidrug resistance protein FOC88_05375 ENOG4105WZW rhodanese family FOC88_05380 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC88_05415 ENOG4107YBY Hydrolase FOC88_05425 ENOG4105CBJ Metal-dependent enzyme FOC88_05440 ENOG4105DC7 peptidase M24 FOC88_05465 ENOG4105CD2 stage iii sporulation protein aa FOC88_05470 ENOG4105KR5 Stage iii sporulation protein FOC88_05475 ENOG4108CQH stage III sporulation protein AC FOC88_05480 ENOG4105KQ4 Stage iii sporulation protein ad FOC88_05490 ENOG410644B Stage III sporulation protein af FOC88_05515 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC88_05520 ENOG4108ZSR alkaline shock protein FOC88_05545 ENOG4105CTB Polyprenyl synthetase FOC88_05555 ENOG4105DX0 Hemolysin A FOC88_05565 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC88_05570 ENOG4105S1Z Stage IV sporulation protein B FOC88_05575 ENOG4107QQR Sporulation FOC88_05590 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC88_05600 ENOG4108JUB Transcriptional regulator FOC88_05610 ENOG4107RDP Dehydrogenase FOC88_05630 ENOG4105CPP Dehydrogenase, E1 component FOC88_05635 ENOG4105C7S Dehydrogenase FOC88_05645 ENOG4105E09 nadh pyrophosphatase FOC88_05650 ENOG4105G7B Protein of unknown function (DUF2992) FOC88_05660 ENOG4108HW3 (ABC) transporter FOC88_05665 ENOG4105E5Q amino acid AbC transporter FOC88_05670 ENOG4105CDA abc transporter atp-binding protein FOC88_05675 ENOG4108QEG Membrane FOC88_05680 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC88_05695 ENOG4105D9U N-acetyltransferase FOC88_05700 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC88_05710 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC88_05735 ENOG4105EJQ L-serine dehydratase FOC88_05740 ENOG4105II7 pyrroline-5-carboxylate reductase FOC88_05745 ENOG41069FQ Metallo-beta-lactamase superfamily FOC88_05750 ENOG4108IXY short-chain dehydrogenase reductase FOC88_05765 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC88_05805 ENOG4105CGH 5'-nucleotidase FOC88_05810 ENOG4105DFD Na H antiporter FOC88_05820 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC88_05835 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC88_05840 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC88_05865 ENOG4108R6K riboflavin synthase, subunit alpha FOC88_05870 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC88_05890 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC88_05895 ENOG4105ETE Transcriptional regulator (LacI family FOC88_05905 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC88_05925 ENOG4105RHY Pfam:UPF0157 FOC88_05935 ENOG4105CPC Aldo Keto reductase FOC88_05955 ENOG4105MZ9 stage II sporulation protein m FOC88_05960 ENOG4105I3K Ferric uptake regulator, Fur family FOC88_05970 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC88_05995 ENOG4105D7N magnesium and cobalt transport protein CorA FOC88_06030 ENOG4105DVE abc transporter atp-binding protein FOC88_06035 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC88_06040 ENOG4105DZ1 carboxypeptidase FOC88_06045 ENOG41082AN stage II sporulation protein FOC88_06055 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_06060 ENOG4105C8J )-transporter FOC88_06080 ENOG41090VF Stage v sporulation protein ac FOC88_06085 ENOG4105CZ3 stage V sporulation protein ad FOC88_06095 ENOG4105G6R Stage v sporulation protein ae FOC88_06105 ENOG4105J7I hydrolase FOC88_06110 ENOG4105PTM secreted protein FOC88_06115 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC88_06150 ENOG4105CE4 GlcNAc 6-P deacetylase FOC88_06170 ENOG4105CID antiterminator FOC88_06185 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC88_06205 ENOG4106TD9 Diguanylate cyclase FOC88_06210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC88_06250 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC88_06270 ENOG4105DTD Dehydrogenase FOC88_06275 ENOG4105K7K Transcriptional regulator FOC88_06310 ENOG4105CHU acetyl-coa acetyltransferase FOC88_06355 ENOG4105CG3 alpha amylase, catalytic region FOC88_06365 ENOG4107FKK extracellular solute-binding protein family 1 FOC88_06375 ENOG4105EG2 ABC transporter, permease FOC88_06380 ENOG4105FKQ transcriptional regulator FOC88_06385 ENOG4105CHM Aminotransferase FOC88_06395 ENOG4108HGU Histidine kinase FOC88_06450 ENOG4105UIN FOC88_06460 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC88_06475 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC88_06480 ENOG4105EPM Diguanylate phosphodiesterase FOC88_06495 ENOG4107IN1 Protein of unknown function (DUF1797) FOC88_06505 ENOG4108XRC Protein of unknown function (DUF458) FOC88_06540 ENOG4107ZYR domain protein FOC88_06545 ENOG4105CN5 Metallo-Beta-Lactamase FOC88_06555 ENOG4108X4Q Hydrolase FOC88_06560 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC88_06575 ENOG4105CPP Dehydrogenase, E1 component FOC88_06625 ENOG4105CXN decarboxylase FOC88_06645 ENOG4105ECY inositol monophosphatase FOC88_06655 ENOG4105CI3 gtp-binding protein typa FOC88_06660 ENOG4105QA2 FOC88_06680 ENOG4108IAB Phoh family FOC88_06695 ENOG4105CNI cell division protein FtsW FOC88_06700 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC88_06750 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC88_06765 ENOG4107TB6 phosphoglycerate mutase FOC88_06785 ENOG4106H78 methyltransferase FOC88_06795 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC88_06800 ENOG4105D78 K07001 NTE family protein FOC88_06805 ENOG41063PX domain protein FOC88_06815 ENOG4105KNH Nucleic acid-binding protein FOC88_06850 ENOG41068DC Essential cell division protein (By similarity) FOC88_06855 ENOG4105CJN penicillin-binding protein FOC88_06860 ENOG4105CJN penicillin-binding protein FOC88_06865 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC88_06880 ENOG4105CNI cell division protein FtsW FOC88_06890 ENOG4105D4A Cell wall formation (By similarity) FOC88_06895 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC88_06900 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC88_06905 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC88_06915 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_06925 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC88_06930 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC88_06935 ENOG4105DFA alanine racemase domain protein FOC88_06945 ENOG41067XK integral membrane protein FOC88_06950 ENOG4105DBK s4 domain protein FOC88_06975 ENOG4105C34 Pseudouridine synthase FOC88_07055 ENOG4105DC7 peptidase M24 FOC88_07070 ENOG4105DSJ YicC domain protein FOC88_07090 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC88_07095 ENOG4105C25 Primosomal protein n' FOC88_07100 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC88_07110 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC88_07120 ENOG4108ZF3 Phosphatase FOC88_07125 ENOG4105D9P serine threonine protein kinase FOC88_07130 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC88_07135 ENOG4105DJV ribulose-phosphate 3-epimerase FOC88_07140 ENOG4105FJ0 thiamine FOC88_07155 ENOG4108ZAA Alkaline-shock protein FOC88_07160 ENOG4105DP4 dak2 domain fusion protein ylov FOC88_07165 ENOG4105CB5 ATP-dependent DNA helicase recG FOC88_07180 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC88_07185 ENOG4105CHR reductase FOC88_07200 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC88_07205 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC88_07225 ENOG4105VB6 UPF0109 protein FOC88_07250 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC88_07265 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC88_07270 ENOG4105C79 DNA protecting protein DprA FOC88_07275 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC88_07285 ENOG4108HE4 integrase family FOC88_07330 ENOG4105KNE Phosphatidate cytidylyltransferase FOC88_07340 ENOG4105DZP Membrane-associated zinc metalloprotease FOC88_07350 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC88_07360 ENOG4105CHV Transcription elongation factor NusA FOC88_07365 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC88_07370 ENOG4105VHM ribosomal protein FOC88_07380 ENOG4105W7A Protein of unknown function (DUF503) FOC88_07390 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC88_07395 ENOG4105DTN riboflavin biosynthesis protein ribF FOC88_07415 ENOG4105C1V Peptidase, M16 FOC88_07425 ENOG4105E35 Dipicolinate synthase subunit A FOC88_07430 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC88_07435 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC88_07445 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC88_07455 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC88_07465 ENOG4107QZI cell division protein FtsK FOC88_07470 ENOG4105FDP GntR family transcriptional regulator FOC88_07475 ENOG4105DIH basic membrane FOC88_07480 ENOG4108JQ9 ABC transporter FOC88_07485 ENOG4105UIB (ABC) transporter FOC88_07505 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC88_07510 ENOG4105XZV Protein of unknown function (DUF3243) FOC88_07525 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC88_07550 ENOG4105D48 metallophosphoesterase FOC88_07555 ENOG4105MCT stage V sporulation protein S FOC88_07560 ENOG4108IGT Dipeptidase FOC88_07565 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC88_07570 ENOG4105DQU oxidoreductase, subunit beta FOC88_07600 ENOG4107QHE Choloylglycine hydrolase FOC88_07610 ENOG410890F Dynamin family FOC88_07615 ENOG4105E0M Sulfatase FOC88_07620 ENOG4107R6R udp-galactopyranose mutase FOC88_07625 ENOG4105F0V Cell wall hydrolase FOC88_07650 ENOG4107YEI lmbE family FOC88_07655 ENOG4107TTQ Alpha beta hydrolase fold FOC88_07670 ENOG41067MG lrgb family FOC88_07685 ENOG4105BZU Histidine kinase FOC88_07690 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_07720 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC88_07725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC88_07735 ENOG4105CGK Exodeoxyribonuclease III FOC88_07755 ENOG4105E0A ABC, transporter FOC88_07760 ENOG4105NIV Esterase FOC88_07770 ENOG4105VPX protein, conserved in bacteria FOC88_07775 ENOG410681U heavy metal transport detoxification protein FOC88_07780 ENOG4105C59 p-type ATPase FOC88_07790 ENOG4105K70 DNA-binding protein FOC88_07795 ENOG4105TMB Formate nitrite transporter FOC88_07815 ENOG4105C85 amino acid FOC88_07825 ENOG4108SJC Membrane FOC88_07830 ENOG4107QW4 alcohol dehydrogenase FOC88_07835 ENOG4105E98 transcriptional regulator DeoR family FOC88_07840 ENOG4105DE4 1-phosphofructokinase FOC88_07845 ENOG4105DM4 PTS System FOC88_07850 ENOG41069ER domain protein FOC88_07880 ENOG4106F1P AAA ATPase, central domain protein FOC88_07885 ENOG4105EN6 Membrane FOC88_07890 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC88_07895 ENOG4105CXI aluminum resistance protein FOC88_07900 ENOG4105KV4 Transcriptional regulator FOC88_07905 ENOG4105C5F glutamine synthetase FOC88_08010 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC88_08200 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC88_08240 ENOG4105K7K Transcriptional regulator FOC88_08260 ENOG4108SVB resolvase FOC88_08270 ENOG4105CGH 5'-nucleotidase FOC88_08280 ENOG4105D5T phosphonate abc transporter FOC88_08295 ENOG4105D7V transposase FOC88_08315 ENOG4105BZ1 (ABC) transporter FOC88_08320 ENOG4105BZ1 (ABC) transporter FOC88_08335 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC88_08360 ENOG41067MG lrgb family FOC88_08370 ENOG4107RSM transcriptional regulator FOC88_08380 ENOG4105CJ1 ABC, transporter FOC88_08400 ENOG4107QIV Cytochrome c biogenesis protein FOC88_08465 ENOG4108903 Formimidoylglutamase FOC88_08470 ENOG4108VJ1 Transcriptional regulator (CarD family FOC88_08475 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC88_08480 ENOG4105CBC glutamate synthase FOC88_08485 ENOG4105CK7 Sodium proline symporter FOC88_08490 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC88_08495 ENOG4105FBA Phospholipase Carboxylesterase FOC88_08500 ENOG4105BZU Histidine kinase FOC88_08510 ENOG4107AYK membrAne FOC88_08560 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_08565 ENOG4107ZYJ bioY protein FOC88_08570 ENOG4107F3J Amp-dependent synthetase and ligase FOC88_08590 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC88_08630 ENOG4108I0Z Aconitate hydratase FOC88_08635 ENOG4108JJA ABC, transporter FOC88_08645 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC88_08650 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC88_08680 ENOG4105W8X HesB YadR YfhF-family protein FOC88_08690 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC88_08700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_08705 ENOG4105C0H protease FOC88_08710 ENOG4105K4P CoA-binding domain protein FOC88_08715 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC88_08725 ENOG4105D9R oxidoreductase FOC88_08735 ENOG4105CIG ABC transporter FOC88_08755 ENOG4105EMN RNA polymerase sigma factor FOC88_08765 ENOG4108KGH TRANSCRIPTIONal FOC88_08770 ENOG4107QJT sodium dicarboxylate symporter FOC88_08835 ENOG4105E1K spore germination protein FOC88_08840 ENOG4108JB9 formate dehydrogenase FOC88_08850 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC88_08855 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC88_08865 ENOG4105TMB Formate nitrite transporter FOC88_08870 ENOG4105D06 uba thif-type nad fad binding protein FOC88_08875 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC88_08880 ENOG4108ZAF Molybdopterin FOC88_08890 ENOG4105D1F ATP-binding protein FOC88_08905 ENOG410696E Membrane FOC88_08910 ENOG4105FR1 rard protein FOC88_08920 ENOG4105EWU Squalene--hopene cyclase FOC88_08930 ENOG4105CHR reductase FOC88_08935 ENOG4105C26 Dehydrogenase FOC88_08945 ENOG4108IA2 Sodium pantothenate symporter FOC88_08960 ENOG4106IQC argininosuccinate lyase FOC88_08970 ENOG410904N short-chain dehydrogenase reductase FOC88_08990 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC88_09010 ENOG4105VEQ Cold shock protein FOC88_09030 ENOG4108R1P FOC88_09040 ENOG41073R8 VanW family FOC88_09045 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_09055 ENOG4105KT7 mgtC SapB transporter FOC88_09065 ENOG4105E39 Enoyl-CoA hydratase FOC88_09070 ENOG4105K64 Glycosyl transferase, family 2 FOC88_09080 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC88_09105 ENOG4105CQB FAD linked oxidase domain protein FOC88_09110 ENOG4105C09 Bile acid FOC88_09145 ENOG4105CIS alcohol dehydrogenase FOC88_09150 ENOG41082BM Transcriptional regulator, arsr family FOC88_09175 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC88_09205 ENOG4108A04 Beta-lactamase FOC88_09210 ENOG4105DPN Oligoendopeptidase f FOC88_09215 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC88_09220 ENOG4105E5K Alpha-amylase FOC88_09230 ENOG4105C98 muts2 protein FOC88_09250 ENOG4107V2S Transcriptional regulator FOC88_09260 ENOG4107CUJ Protein of unknown function (DUF2690) FOC88_09285 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC88_09290 ENOG4105NX3 Membrane FOC88_09295 ENOG4105DQ5 transport system permease protein FOC88_09300 ENOG4105EHG Permease protein FOC88_09305 ENOG4108MES Periplasmic binding protein FOC88_09320 ENOG4107R3E Citrate transporter FOC88_09330 ENOG4108TN2 lmbE family FOC88_09365 ENOG4105CIS alcohol dehydrogenase FOC88_09400 ENOG4105H3G oxidoreductase FOC88_09450 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC88_09475 ENOG4105KAF membrAne FOC88_09530 ENOG4105KVH Transcriptional regulator FOC88_09535 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC88_09550 ENOG4105CHR reductase FOC88_09560 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC88_09600 ENOG4105KVH Transcriptional regulator FOC88_09605 ENOG4105KVH Transcriptional regulator FOC88_09610 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC88_09615 ENOG4105D9R oxidoreductase FOC88_09620 ENOG4108TZY GntR Family Transcriptional Regulator FOC88_09660 ENOG4105C44 Serine transporter FOC88_09695 ENOG4105D4Y metalloprotease FOC88_09700 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC88_09715 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC88_09730 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC88_09745 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC88_09750 ENOG4105C6Z Gluconate FOC88_09755 ENOG4105CMG Carbohydrate kinase FOC88_09760 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC88_09765 ENOG4105XDF Protein of unknown function (DUF1272) FOC88_09770 ENOG4105DDN Pentapeptide repeat-containing protein FOC88_09785 ENOG4105C37 (CBS) domain FOC88_09815 ENOG4105EV4 Multidrug resistance protein mdtH FOC88_09825 ENOG4105DMQ Methyltransferase FOC88_09865 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC88_09875 ENOG4108UW5 maltose o-acetyltransferase FOC88_09880 ENOG4106UW1 Major Facilitator superfamily FOC88_09885 ENOG4105DKQ ROK family FOC88_09890 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_09950 ENOG4105CJ1 ABC, transporter FOC88_09960 ENOG4108PSK reductase FOC88_09980 ENOG4108RCM Nitroreductase FOC88_09985 ENOG4105KVH Transcriptional regulator FOC88_10000 ENOG4105CUT histidyl-tRNA synthetase FOC88_10005 ENOG4108Z66 YbaK ebsC protein FOC88_10015 ENOG41067QW Transcriptional regulator FOC88_10025 ENOG4108IND Tetr family transcriptional regulator FOC88_10030 ENOG4105EQ0 Major Facilitator superfamily FOC88_10065 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC88_10100 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC88_10110 ENOG4105CRW Short chain fatty acid transporter FOC88_10120 ENOG4105KBX Transcriptional regulator, TetR family FOC88_10125 ENOG4105KPY Small multidrug resistance protein FOC88_10130 ENOG4105RXJ FOC88_10140 ENOG41069JR FOC88_10145 ENOG4105DA5 (ABC) transporter FOC88_10160 ENOG4105CZM Major Facilitator FOC88_10165 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC88_10175 ENOG4108ISG Major Facilitator FOC88_10215 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC88_10235 ENOG410874W AraC family transcriptional regulator FOC88_10240 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC88_10260 ENOG4108JQ1 Dehydrogenase FOC88_10275 ENOG4105DVH amino acid FOC88_10285 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC88_10300 ENOG4108JPW Aminotransferase FOC88_10315 ENOG4105EJQ L-serine dehydratase FOC88_10320 ENOG4105C44 Serine transporter FOC88_10355 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC88_10390 ENOG4105TRI Hydrolase FOC88_10425 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC88_10435 ENOG4106P55 Transcriptional regulator FOC88_10445 ENOG4107QR9 Iron-sulfur cluster binding protein FOC88_10455 ENOG4105DJB Major Facilitator Superfamily FOC88_10460 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC88_10470 ENOG4105BZU Histidine kinase FOC88_10485 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC88_10490 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC88_10505 ENOG4105JQZ Methyltransferase FOC88_10510 ENOG4105W1Y Transcriptional regulator FOC88_10520 ENOG4105C88 aminopeptidase FOC88_10535 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC88_10545 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC88_10550 ENOG4108NNI Beta-lactamase domain-containing protein FOC88_10575 ENOG4105K6H D-cysteine desulfhydrase FOC88_10600 ENOG41062D9 Histidine kinase FOC88_10605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_10620 ENOG4105IIP Membrane FOC88_10630 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_10635 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC88_10710 ENOG4108YXU transcriptional regulator AsnC family FOC88_10715 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC88_10720 ENOG4108IG5 Transcriptional regulator FOC88_10725 ENOG4107P5I polyketide synthase FOC88_10740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_10745 ENOG4105BZU Histidine kinase FOC88_10765 ENOG41085FC arsR family transcriptional regulator FOC88_10770 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_10775 ENOG4105D6J arsenicaL-resistance protein FOC88_10785 ENOG4105DBI uridine monophosphokinase FOC88_10810 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC88_10815 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC88_10830 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC88_10835 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC88_10850 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC88_10855 ENOG4108606 TspO/MBR family FOC88_10890 ENOG41090MY MarR family Transcriptional regulator FOC88_10915 ENOG4105CHJ isochorismatase hydrolase FOC88_10925 ENOG4105CH6 catalase FOC88_10930 ENOG4105CGH 5'-nucleotidase FOC88_10965 ENOG4105CSV Glutaminase FOC88_10985 ENOG4108Q8B Spore germination protein FOC88_10990 ENOG4108NHD germination protein FOC88_11000 ENOG4105C6K Malic enzyme FOC88_11010 ENOG4105II7 pyrroline-5-carboxylate reductase FOC88_11020 ENOG4105CUB amino acid FOC88_11025 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC88_11030 ENOG4105YWU small acid-soluble spore protein FOC88_11040 ENOG41075H3 AraC family transcriptional regulator FOC88_11065 ENOG4105BZU Histidine kinase FOC88_11075 ENOG4108B31 Spore germination protein FOC88_11095 ENOG4108IMY Transcriptional regulator FOC88_11100 ENOG4105HDK L-asparaginase FOC88_11105 ENOG4108IJ0 Aspartate ammonia-lyase FOC88_11115 ENOG4105E2A Dehydrogenase FOC88_11180 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC88_11210 ENOG4105DWD nucleoside recognition domain protein FOC88_11225 ENOG4105FDT acyl-CoA dehydrogenase FOC88_11235 ENOG4108ZHR arsR family transcriptional regulator FOC88_11240 ENOG4108ZRV stage ii sporulation protein p FOC88_11245 ENOG4106N3A copper homeostasis protein cutc FOC88_11255 ENOG4107258 Transcriptional regulator FOC88_11260 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC88_11300 ENOG4107RF6 penicillin-binding protein FOC88_11340 ENOG4105F1N DNA alkylation repair FOC88_11350 ENOG4108IQI permease FOC88_11355 ENOG4105KNA -acetyltransferase FOC88_11360 ENOG410635A Membrane FOC88_11420 ENOG4108XET gCN5-related N-acetyltransferase FOC88_11450 ENOG4105C19 ABC transporter FOC88_11460 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC88_11490 ENOG4105EFZ amidohydrolase FOC88_11495 ENOG4105D2S major facilitator superfamily FOC88_11500 ENOG4105G9B Transcriptional regulator FOC88_11510 ENOG4105VZJ PTS System FOC88_11525 ENOG4108QVC Component IIC FOC88_11530 ENOG4105VCP PTS System FOC88_11535 ENOG4105CS2 ec 3.2.1.21 FOC88_11540 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC88_11545 ENOG4105E39 Enoyl-CoA hydratase FOC88_11550 ENOG4105CHU acetyl-coa acetyltransferase FOC88_11555 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_11560 ENOG41082UD thioesterase Superfamily protein FOC88_11575 ENOG4105ERH Fumarylacetoacetate hydrolase FOC88_11595 ENOG4105FS7 Transcriptional regulator FOC88_11600 ENOG4108TVJ Nitroreductase FOC88_11645 ENOG4105C8Y Acetylornithine aminotransferase FOC88_11655 ENOG4105CKK Glycosyl transferase, family 2 FOC88_11670 ENOG4105CKK Glycosyl transferase, family 2 FOC88_11680 ENOG4105CSH Transporter FOC88_11695 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC88_11720 ENOG41068WN FOC88_11730 ENOG4108WCX response regulator FOC88_11740 ENOG41090T1 Membrane FOC88_11755 ENOG4105VMP Transcriptional regulator FOC88_11765 ENOG4105G6Z alkaline phosphatase FOC88_11770 ENOG4105ECK Fatty Acid Desaturase FOC88_11775 ENOG4105E0Y RtcB Protein FOC88_11785 ENOG4107258 Transcriptional regulator FOC88_11795 ENOG4105II7 pyrroline-5-carboxylate reductase FOC88_11830 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC88_11850 ENOG41061GT Aldolase FOC88_11860 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC88_11865 ENOG4105DKT Transcriptional regulator FOC88_11875 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC88_11880 ENOG4105F5R ABC transporter FOC88_11885 ENOG4105D4B ABC, transporter FOC88_11900 ENOG4108JUB Transcriptional regulator FOC88_11905 ENOG4105J5T Amp-dependent synthetase and ligase FOC88_11910 ENOG4105E39 Enoyl-CoA hydratase FOC88_11915 ENOG4105CY2 Citrate transporter FOC88_11925 ENOG41069ER domain protein FOC88_11940 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC88_11960 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC88_11970 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC88_11990 ENOG41082JN Transcriptional regulator FOC88_11995 ENOG4105EYF MMPL domain protein FOC88_12005 ENOG4105C5H ABC transporter FOC88_12010 ENOG4105E0M Sulfatase FOC88_12015 ENOG4108ZCF integral membrane protein FOC88_12035 ENOG4107VC0 DNA alkylation repair enzyme FOC88_12085 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC88_12105 ENOG4105E09 nadh pyrophosphatase FOC88_12130 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC88_12135 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC88_12140 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC88_12150 ENOG4105C02 permease FOC88_12190 ENOG4108ZMI UPF0477 protein FOC88_12205 ENOG4105CHM Aminotransferase FOC88_12245 ENOG41089UC methyltransferase, type 11 FOC88_12260 ENOG4107BMA Transglycosylase associated protein FOC88_12280 ENOG4106K7D Major facilitator family transporter FOC88_12285 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC88_12325 ENOG4105EPR degv family FOC88_12335 ENOG4105DPN Oligoendopeptidase f FOC88_12365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_12370 ENOG4105BZU Histidine kinase FOC88_12375 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC88_12420 ENOG4105DTQ mandelate racemase muconate lactonizing FOC88_12435 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC88_12440 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC88_12455 ENOG4107T5V SNARE associated Golgi FOC88_12485 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC88_12495 ENOG41080HI glycine oxidase FOC88_12500 ENOG4105CTU Proline racemase FOC88_12505 ENOG4105CTU Proline racemase FOC88_12510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC88_12515 ENOG4105C26 Dehydrogenase FOC88_12520 ENOG4105BZG amino acid carrier protein FOC88_12540 ENOG4108M1A Chitin-binding protein FOC88_12585 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC88_12605 ENOG4105EEM helicase FOC88_12625 ENOG4108Z7F N-acetyltransferase FOC88_12655 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC88_12680 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC88_12700 ENOG41087PP glycosyltransferase MGT family FOC88_12705 ENOG4108M1A Chitin-binding protein FOC88_12710 ENOG41082BV acetyltransferase FOC88_12740 ENOG4108IJ7 Glycine betaine FOC88_12745 ENOG4107SQ8 Glycine betaine FOC88_12775 ENOG4105DBI uridine monophosphokinase FOC88_12780 ENOG4105RHY Pfam:UPF0157 FOC88_12785 ENOG4105E1F short-chain dehydrogenase reductase FOC88_12795 ENOG4107RUY (E1 component), alpha subunit FOC88_12805 ENOG4107QKR Dehydrogenase FOC88_12830 ENOG4105E98 transcriptional regulator DeoR family FOC88_12850 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC88_12870 ENOG4107Z3H Transcriptional regulator, TetR family FOC88_12905 ENOG4105MSI germination protein ypeb FOC88_12965 ENOG4105FDR Membrane FOC88_12975 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC88_13000 ENOG4108IUM Glycogen debranching enzyme FOC88_13015 ENOG4105DY8 decarboxylase FOC88_13055 ENOG4107VFR oxidoreductase FOC88_13095 ENOG4105PKS Excinuclease abc c subunit domain protein FOC88_13130 ENOG4105KWG Pfam:DUF1696 FOC88_13135 ENOG4108NRW Phospholipase, patatin family FOC88_13155 ENOG4108XI2 Domain of unknown function (DUF1963) FOC88_13180 ENOG4108Z4K mutator MutT protein FOC88_13185 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC88_13190 ENOG4105E09 nadh pyrophosphatase FOC88_13205 ENOG4105FCD Major Facilitator FOC88_13240 ENOG4107Y9U Membrane FOC88_13260 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC88_13275 ENOG4107Y80 Major Facilitator superfamily FOC88_13330 ENOG4105FQP Beta-lactamase FOC88_13340 ENOG4105CJN penicillin-binding protein FOC88_13345 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC88_13350 ENOG4105CB2 alcohol dehydrogenase FOC88_13365 ENOG4108HGU Histidine kinase FOC88_13380 ENOG4108JJB ABC transporter FOC88_13400 ENOG4107RF6 penicillin-binding protein FOC88_13405 ENOG4105BZU Histidine kinase FOC88_13410 ENOG410667J hydrolase FOC88_13495 ENOG4105ETU transcriptional activator (TenA FOC88_13590 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC88_13605 ENOG4105CPQ Dehydrogenase FOC88_13650 ENOG4105CUV Homoserine Kinase FOC88_13665 ENOG41089UC methyltransferase, type 11 FOC88_13685 ENOG4108V4B ThiJ pfpI FOC88_13705 ENOG4105FQP Beta-lactamase FOC88_13720 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC88_13750 ENOG41075H3 AraC family transcriptional regulator FOC88_13775 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC88_13785 ENOG4105T9C HD domain FOC88_13815 ENOG4105DBI uridine monophosphokinase FOC88_13820 ENOG4105WCN acetyltransferase FOC88_13830 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC88_13835 ENOG4107QX3 carboxylase FOC88_13840 ENOG4105E39 Enoyl-CoA hydratase FOC88_13845 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC88_13850 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC88_13855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC88_13860 ENOG4105C1G acyl-Coa dehydrogenase FOC88_13875 ENOG4107Z3H Transcriptional regulator, TetR family FOC88_13885 ENOG4105CJ1 ABC, transporter FOC88_13900 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC88_13925 ENOG4105BZU Histidine kinase FOC88_13935 ENOG4105C5H ABC transporter FOC88_13940 ENOG41067SE Tetr family transcriptional regulator FOC88_13955 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC88_13970 ENOG4108VXD carboxy-peptidase FOC88_13985 ENOG4105VZ8 Transcriptional regulator FOC88_14000 ENOG4105CGH 5'-nucleotidase FOC88_14015 ENOG4105DH8 myo-inositol catabolism FOC88_14020 ENOG4105D2N Aldolase FOC88_14045 ENOG4105CK5 oxidoreductase FOC88_14050 ENOG4105IE8 Alpha-ketoglutarate permease FOC88_14055 ENOG4105ETE Transcriptional regulator (LacI family FOC88_14065 ENOG4107RF6 penicillin-binding protein FOC88_14070 ENOG4107RF6 penicillin-binding protein FOC88_14095 ENOG4105CIN aminoacyl-histidine dipeptidase FOC88_14135 ENOG41090HR transcriptional regulator FOC88_14140 ENOG4107RA9 decarboxylase FOC88_14155 ENOG41088CC tellurite resistance protein tehB FOC88_14175 ENOG4108RZE Tetr family transcriptional regulator FOC88_14190 ENOG4105C1J atp-dependent rna helicase FOC88_14205 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC88_14240 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC88_14250 ENOG4105RD7 BadF BadG BcrA BcrD FOC88_14275 ENOG4105F32 YngK protein FOC88_14300 ENOG4108KPJ rna polymerase sigma factor FOC88_14305 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC88_14315 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC88_14345 ENOG4108JCI Transcriptional regulator FOC88_14365 ENOG4105BZ1 (ABC) transporter FOC88_14370 ENOG4105BZ1 (ABC) transporter FOC88_14385 ENOG4108RPX mosc domain containing protein FOC88_14390 ENOG4105DND Transcriptional regulator FOC88_14405 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC88_14410 ENOG4107V2S Transcriptional regulator FOC88_14450 ENOG410667J hydrolase FOC88_14470 ENOG4105VEQ Cold shock protein FOC88_14480 ENOG41068WN FOC88_14485 ENOG41089UC methyltransferase, type 11 FOC88_14495 ENOG4105C1Q protoporphyrinogen oxidase FOC88_14525 ENOG4105WCN acetyltransferase FOC88_14550 ENOG4105EYF MMPL domain protein FOC88_14560 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC88_14575 ENOG4108Y4K DNA-binding transcriptional activator FOC88_14585 ENOG41081I9 integral membrane protein FOC88_14630 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC88_14640 ENOG4105C19 ABC transporter FOC88_14645 ENOG4105C22 threonyL-tRNA synthetase FOC88_14650 ENOG4105FE9 pseudouridine synthase FOC88_14670 ENOG4105BZG amino acid carrier protein FOC88_14690 ENOG4105K70 DNA-binding protein FOC88_14705 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_14710 ENOG4105WQT MbtH domain protein FOC88_14715 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_14720 ENOG4105WQI isochorismatase FOC88_14725 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC88_14730 ENOG4105E4F Isochorismate synthase FOC88_14735 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC88_14740 ENOG4105FCD Major Facilitator FOC88_14880 ENOG4105VTR Integrase FOC88_14885 ENOG4105EYH Exonuclease FOC88_14890 ENOG4107RFY SbcCD D subunit FOC88_14905 ENOG4105E39 Enoyl-CoA hydratase FOC88_14910 ENOG4105N14 lysine exporter protein LysE YggA FOC88_14920 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC88_14925 ENOG4105C1G acyl-Coa dehydrogenase FOC88_14930 ENOG4105CR4 methylisocitrate lyase FOC88_14935 ENOG4105DXD 2-methylcitrate dehydratase FOC88_14945 ENOG4105W8X HesB YadR YfhF-family protein FOC88_14950 ENOG4105CZM Major Facilitator FOC88_14955 ENOG4105BZ4 penicillin-binding protein FOC88_14995 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC88_15050 ENOG4105SZ6 Thioredoxin FOC88_15060 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC88_15065 ENOG4108N23 SpoOM-related protein FOC88_15105 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC88_15110 ENOG4108JUB Transcriptional regulator FOC88_15115 ENOG4108TSC N-acetyltransferase FOC88_15120 ENOG4107S4Y M20 DapE family protein YgeY FOC88_15135 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC88_15160 ENOG4105C37 (CBS) domain FOC88_15195 ENOG4105E90 ABC transporter FOC88_15200 ENOG4108IJ8 ABC transporter FOC88_15270 ENOG4105WH1 Two component transcriptional regulator luxr family FOC88_15275 ENOG4105BZU Histidine kinase FOC88_15280 ENOG4105D8X mechanosensitive ion channel FOC88_15285 ENOG4107Y70 Heat shock protein FOC88_15315 ENOG4105F0I Aminotransferase FOC88_15320 ENOG4108MES Periplasmic binding protein FOC88_15335 ENOG4105CAQ asparagine synthetase FOC88_15340 ENOG4107Y70 Heat shock protein FOC88_15345 ENOG4108KF3 Electron transport protein SCO1 SenC FOC88_15350 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC88_15355 ENOG4108RCR degv family FOC88_15365 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC88_15375 ENOG4108UT2 hemolysin iii FOC88_15380 ENOG4105E9Q Acyl-transferase FOC88_15390 ENOG4107RVG penicillin-binding protein FOC88_15410 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC88_15430 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC88_15455 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC88_15460 ENOG4105KD7 acetyltransferase FOC88_15475 ENOG4105C0A alcohol dehydrogenase FOC88_15480 ENOG4105CY2 Citrate transporter FOC88_15485 ENOG4107XGZ Hydrolase FOC88_15505 ENOG4105C8J )-transporter FOC88_15520 ENOG41062D9 Histidine kinase FOC88_15525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_15530 ENOG4107QPK )-transporter FOC88_15535 ENOG4105BZW Glycerate kinase FOC88_15615 ENOG4106ANW SMI1_KNR4 FOC88_15620 ENOG4106BHF FOC88_15645 ENOG4105EC2 ftsk spoIIIe FOC88_15665 ENOG4105C5S asparaginyl-tRNA synthetase FOC88_15715 ENOG4107YX5 Pfam:DUF548 FOC88_15735 ENOG4108UUM single-stranded DNA-binding protein FOC88_15750 ENOG4105C5H ABC transporter FOC88_15770 ENOG4105MCT stage V sporulation protein S FOC88_15805 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC88_15810 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC88_15815 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC88_15820 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC88_15825 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC88_15830 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC88_15850 ENOG4108ZAF Molybdopterin FOC88_15855 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC88_15860 ENOG4105D06 uba thif-type nad fad binding protein FOC88_15865 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC88_15870 ENOG4107V6Q Cyclic nucleotide-binding domain FOC88_15880 ENOG4105CZV ABC transporter FOC88_15895 ENOG4105R3A Nitrate reductase FOC88_15900 ENOG4108IUE nitrate reductase beta subunit FOC88_15910 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC88_15925 ENOG4108V06 Glutathione peroxidase FOC88_15945 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOC88_15960 ENOG4105EMN RNA polymerase sigma factor FOC88_15965 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC88_15975 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC88_15980 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FOC88_16000 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC88_16025 ENOG4105KBJ sporulation protein ytfj FOC88_16050 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC88_16080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC88_16085 ENOG4108JYZ YitT family FOC88_16105 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC88_16115 ENOG4108X4Q Hydrolase FOC88_16140 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC88_16150 ENOG4108VXD carboxy-peptidase FOC88_16160 ENOG4108ZRV stage ii sporulation protein p FOC88_16180 ENOG4108Z7R Chaperone CsaA FOC88_16200 ENOG4105C37 (CBS) domain FOC88_16205 ENOG4105SXS Protein of unknown function (DUF456) FOC88_16225 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC88_16235 ENOG4108S4H thioesterase Superfamily protein FOC88_16245 ENOG4108PJD permease FOC88_16260 ENOG4107T5V SNARE associated Golgi FOC88_16280 ENOG4105CVJ phosphoglycerate mutase FOC88_16305 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC88_16315 ENOG4105K4T epimerase FOC88_16325 ENOG4105DSE periplasmic solute binding protein FOC88_16385 ENOG4105CKI cobalamin synthesis protein FOC88_16390 ENOG4107QM2 Aldo Keto reductase FOC88_16410 ENOG4105DEN Luciferase family FOC88_16425 ENOG4108WPJ Ferritin-like domain FOC88_16430 ENOG4108K88 Membrane FOC88_16445 ENOG4105C8Q Methyl-accepting chemotaxis FOC88_16470 ENOG4107XZQ multidrug resistance protein FOC88_16475 ENOG4107SET aldo keto reductase FOC88_16480 ENOG4105YVS arsR family transcriptional regulator FOC88_16500 ENOG4105KRN Transcriptional regulator, abrb family FOC88_16550 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC88_16560 ENOG4105YWU small acid-soluble spore protein FOC88_16565 ENOG4108WBH protein TIM barrel FOC88_16580 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_16585 ENOG4105DUU IucA IucC family protein FOC88_16595 ENOG4105VRR gCN5-related N-acetyltransferase FOC88_16600 ENOG4105KT7 mgtC SapB transporter FOC88_16615 ENOG4105BZU Histidine kinase FOC88_16620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_16630 ENOG4108KGH TRANSCRIPTIONal FOC88_16655 ENOG4105D6E homoserine dehydrogenase FOC88_16670 ENOG4106AKJ FOC88_16680 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC88_16700 ENOG4105BZU Histidine kinase FOC88_16705 ENOG4105EFI regulatoR FOC88_16710 ENOG4105BZ1 (ABC) transporter FOC88_16740 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC88_16755 ENOG4108JJ8 (ABC) transporter FOC88_16760 ENOG4108JJ9 ABC, transporter FOC88_16765 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC88_16770 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC88_16800 ENOG4105SKE transcriptional Regulator LysR family FOC88_16810 ENOG4105C32 Amino acid ABC transporter (Permease) FOC88_16815 ENOG4108IV0 ABC, transporter FOC88_16820 ENOG4105C0Z ABC transporter FOC88_16830 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC88_16835 ENOG4108Z7G MaoC domain protein dehydratase FOC88_16855 ENOG4105CKI cobalamin synthesis protein FOC88_16870 ENOG4106F5Q Membrane FOC88_16875 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC88_16885 ENOG4108TVJ Nitroreductase FOC88_16890 ENOG4107ZXU DSBA oxidoreductase FOC88_16895 ENOG4108Z40 Transcriptional regulator FOC88_16900 ENOG4105GZI Transcriptional regulator FOC88_16905 ENOG4107RT3 EamA-like transporter family FOC88_16910 ENOG4105KTB nuclear export factor GLE1 FOC88_16915 ENOG4108T5E Copper resistance protein FOC88_16960 ENOG4107R16 Multicopper oxidase FOC88_16965 ENOG4107RAQ aminopeptidase FOC88_17000 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC88_17005 ENOG4105D9N nucleoside FOC88_17015 ENOG4107RHR regulatoR FOC88_17040 ENOG4105C0X amino acid FOC88_17045 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC88_17060 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC88_17080 ENOG41068WN FOC88_17130 ENOG4105CYC Transferase FOC88_17135 ENOG4105DY9 regulatoR FOC88_17145 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC88_17150 ENOG4105C6X Major Facilitator FOC88_17175 ENOG4105C7B Threonine dehydratase FOC88_17185 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC88_17190 ENOG4108ZP8 Acetolactate synthase small subunit FOC88_17195 ENOG4105C7K acetolactate synthase FOC88_17200 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC88_17205 ENOG4105CHR reductase FOC88_17210 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC88_17225 ENOG4105H67 Protein of unknown function (DUF421) FOC88_17230 ENOG4105X5K response regulator receiver protein FOC88_17240 ENOG4105C8J )-transporter FOC88_17260 ENOG4105C6T cysteine synthase FOC88_17265 ENOG4105EU0 Major facilitator Superfamily FOC88_17275 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC88_17290 ENOG4105DXI Major Facilitator superfamily FOC88_17300 ENOG4105U3E Transcriptional regulator FOC88_17305 ENOG4105CSR polyphosphate kinase 2 FOC88_17345 ENOG4105FVX FOC88_17410 ENOG4105C6K Malic enzyme FOC88_17415 ENOG4108IJ0 Aspartate ammonia-lyase FOC88_17425 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC88_17445 ENOG4105CJ1 ABC, transporter FOC88_17480 ENOG4106BRA Membrane FOC88_17510 ENOG4107QIV Cytochrome c biogenesis protein FOC88_17530 ENOG4105EC3 peptidase S51, dipeptidase E FOC88_17535 ENOG4107QJQ Mate efflux family protein FOC88_17555 ENOG4105C9Q fumarate hydratase class II FOC88_17565 ENOG4105VUF Transcriptional regulator FOC88_17570 ENOG4105DFD Na H antiporter FOC88_17585 ENOG4108PJD permease FOC88_17590 ENOG4105CKI cobalamin synthesis protein FOC88_17595 ENOG4108UZ3 Transporter FOC88_17600 ENOG4105DRR Transcriptional regulator, GntR family FOC88_17610 ENOG4105PGM cation diffusion facilitator family transporter FOC88_17630 ENOG4105CAQ asparagine synthetase FOC88_17640 ENOG4105K56 Transcriptional regulator FOC88_17660 ENOG4105CVJ phosphoglycerate mutase FOC88_17700 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC88_17705 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC88_17715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC88_17745 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC88_17780 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC88_17785 ENOG4105KTQ flagellar basal-body rod protein FOC88_17790 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC88_17795 ENOG4105D7B Flagellar biosynthesis protein flha FOC88_17800 ENOG4105D00 flagellar biosynthetic protein flhB FOC88_17810 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC88_17815 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC88_17825 ENOG4105DD5 Flagellar motor switch protein FOC88_17830 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC88_17840 ENOG4105E4C Lytic transglycosylase catalytic FOC88_17845 ENOG4105I03 Flagellin FOC88_17865 ENOG4107R88 Chemotaxis protein (CheV) FOC88_17880 ENOG4105BZE flagellar hook protein, FlgE FOC88_17910 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC88_17925 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC88_17930 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC88_17945 ENOG4107TPX flagellar hook-associated FOC88_17950 ENOG4105DTJ flagellar hook-associated protein FOC88_17955 ENOG4105E1Q flagellar hook-associated protein FOC88_17975 ENOG4105BZU Histidine kinase FOC88_17990 ENOG4105DD5 Flagellar motor switch protein FOC88_17995 ENOG4105CBS Chea signal transduction histidine kinase FOC88_18000 ENOG4107YTP response regulator receiver protein FOC88_18005 ENOG4105ER2 Ompa motb domain protein FOC88_18010 ENOG4107R0U MotA TolQ exbB proton channel FOC88_18020 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC88_18075 ENOG41080C8 DUF218 domain FOC88_18080 ENOG4105H67 Protein of unknown function (DUF421) FOC88_18090 ENOG4108Z5V transcriptional regulator, merr family FOC88_18095 ENOG4105CN5 Metallo-Beta-Lactamase FOC88_18100 ENOG4107RWR Sodium hydrogen exchanger FOC88_18110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC88_18175 ENOG41081VK Ribonuclease FOC88_18195 ENOG4108SZE gCN5-related N-acetyltransferase FOC88_18210 ENOG4105CPK Glycosyl transferase (Group 1 FOC88_18270 ENOG4106032 Glutathionylspermidine synthase FOC88_18295 ENOG4105KHC sulfurtransferase FOC88_18305 ENOG4108W0I acetyltransferase FOC88_18315 ENOG410890F Dynamin family FOC88_18320 ENOG4105DHF Membrane FOC88_18325 ENOG4105C2W permease FOC88_18335 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC88_18350 ENOG4105CTD carboxy-peptidase FOC88_18355 ENOG4105DVT helicase FOC88_18365 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC88_18425 ENOG4105BZ4 penicillin-binding protein FOC88_18435 ENOG4105CSM endonuclease III FOC88_18455 ENOG4105YAC FOC88_18460 ENOG4105DVT helicase FOC88_18495 ENOG4105CPK Glycosyl transferase (Group 1 FOC88_18500 ENOG4105FJR Lmbe family FOC88_18515 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC88_18520 ENOG4108JYZ YitT family FOC88_18550 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC88_18555 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC88_18560 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC88_18575 ENOG41068YB TPR repeat-containing protein FOC88_18580 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC88_18600 ENOG4105EAH synthase FOC88_18610 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC88_18625 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC88_18655 ENOG41065D1 FOC88_18660 ENOG4105S2F FOC88_18695 ENOG4105HDK L-asparaginase FOC88_18700 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC88_18725 ENOG4108S6Z Negative regulator of genetic competence FOC88_18730 ENOG4107X2D transcriptional regulator, merr family FOC88_18735 ENOG4107RGJ metallophosphoesterase FOC88_18745 ENOG4105I7S Abortive infection protein FOC88_18750 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC88_18765 ENOG4108SAX Membrane FOC88_18775 ENOG41063SB peptidase FOC88_18780 ENOG4108WBT adenosyltransferase FOC88_18785 ENOG4105BZU Histidine kinase FOC88_18790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_18795 ENOG4105CRE cytochrome C FOC88_18800 ENOG4107TWT Cytochrome c biogenesis protein FOC88_18810 ENOG4105FE9 pseudouridine synthase FOC88_18820 ENOG4108JIC nucleoside recognition domain protein FOC88_18825 ENOG4105DZ1 carboxypeptidase FOC88_18830 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC88_18865 ENOG4105BZU Histidine kinase FOC88_18880 ENOG4105I3N Conserved Protein FOC88_18885 ENOG4105BZU Histidine kinase FOC88_18900 ENOG4105BZ4 penicillin-binding protein FOC88_18905 ENOG4107GRR phosphate transport regulator FOC88_18910 ENOG4105CJ3 phosphate transporter FOC88_18955 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC88_18975 ENOG4105WH1 Two component transcriptional regulator luxr family FOC88_18980 ENOG4105ENE Histidine kinase FOC88_19000 ENOG4105DFD Na H antiporter FOC88_19020 ENOG4105C8J )-transporter FOC88_19025 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC88_19030 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC88_19035 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC88_19045 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC88_19050 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC88_19070 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC88_19080 ENOG4105E0M Sulfatase FOC88_19085 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC88_19100 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC88_19175 ENOG4108ZP8 Acetolactate synthase small subunit FOC88_19180 ENOG4105C7K acetolactate synthase FOC88_19185 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC88_19205 ENOG4105KBJ sporulation protein ytfj FOC88_19210 ENOG41063Y9 FOC88_19215 ENOG4105CZN Potassium uptake protein FOC88_19245 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC88_19250 ENOG4107QMU Mate efflux family protein FOC88_19285 ENOG4105NQC Flavodoxin FOC88_19310 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC88_19320 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC88_19325 ENOG4105EA8 2-Nitropropane dioxygenase FOC88_19330 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC88_19370 ENOG4105CJ1 ABC, transporter FOC88_19380 ENOG4105CZV ABC transporter FOC88_19385 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC88_19390 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC88_19410 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC88_19450 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC88_19455 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC88_19465 ENOG4105BZU Histidine kinase FOC88_19470 ENOG4106DF1 FOC88_19480 ENOG41090MY MarR family Transcriptional regulator FOC88_19485 ENOG4105BZU Histidine kinase FOC88_19495 ENOG4105PXI polysaccharide deacetylase FOC88_19505 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC88_19515 ENOG4105E98 transcriptional regulator DeoR family FOC88_19535 ENOG4107RCV ABC transporter, permease FOC88_19540 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC88_19545 ENOG4105C4Y ABC transporter FOC88_19565 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC88_19575 ENOG4105CHR reductase FOC88_19595 ENOG4108Z7G MaoC domain protein dehydratase FOC88_19600 ENOG410681C small acid-soluble spore protein FOC88_19605 ENOG4105CZN Potassium uptake protein FOC88_19610 ENOG4107TS3 membrane protein, TerC FOC88_19615 ENOG4108QTI )-transporter FOC88_19625 ENOG4106A3R peptidase FOC88_19645 ENOG4105JXH GntR family transcriptional regulator FOC88_19650 ENOG4105BZU Histidine kinase FOC88_19655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_19670 ENOG4105CQB FAD linked oxidase domain protein FOC88_19675 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC88_19680 ENOG4105K4I Scp-like extracellular FOC88_19690 ENOG4108YBP pseudouridine synthase FOC88_19700 ENOG4105EYF MMPL domain protein FOC88_19710 ENOG4107RUE extracellular solute-binding protein family 1 FOC88_19715 ENOG4105D38 putrescine abc transporter FOC88_19720 ENOG4105F38 ABC transporter, permease FOC88_19730 ENOG4105C26 Dehydrogenase FOC88_19765 ENOG4105VFR signal peptidase FOC88_19770 ENOG4105DZ1 carboxypeptidase FOC88_19780 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC88_19840 ENOG4105VZ8 Transcriptional regulator FOC88_19850 ENOG4105C7S Dehydrogenase FOC88_19940 ENOG4105DDQ anthranilate synthase FOC88_19950 ENOG4105CK7 Sodium proline symporter FOC88_20025 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC88_20035 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC88_20040 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC88_20060 ENOG4107TVC Glycosyl transferase, family 2 FOC88_20080 ENOG4105K64 Glycosyl transferase, family 2 FOC88_20100 ENOG4105EMS pseudouridine synthase FOC88_20120 ENOG4105MIX Adenylate cyclase FOC88_20125 ENOG4108Z18 K06886 hemoglobin FOC88_20140 ENOG4105DPN Oligoendopeptidase f FOC88_20150 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC88_20160 ENOG4108ZCF integral membrane protein FOC88_20180 ENOG4105UQX Mate efflux family protein FOC88_20185 ENOG4108JQ7 (ABC) transporter FOC88_20195 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_20200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC88_20215 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC88_20230 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC88_20235 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC88_20260 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC88_20270 ENOG4108KP7 hydrolase FOC88_20280 ENOG41073B9 FOC88_20285 ENOG4107AYK membrAne FOC88_20295 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC88_20305 ENOG4105QNR S1 RNA binding domain protein FOC88_20325 ENOG4105BZU Histidine kinase FOC88_20330 ENOG4105CH6 catalase FOC88_20335 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC88_20340 ENOG4105CAQ asparagine synthetase FOC88_20365 ENOG4105ERH Fumarylacetoacetate hydrolase FOC88_20430 ENOG4105XVF Competence transcription factor FOC88_20460 ENOG4107QP3 malate synthase g FOC88_20485 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC88_20510 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_20530 ENOG41086D8 Transcriptional regulator FOC88_20535 ENOG4108AEY RNA polymerase sigma factor FOC88_20545 ENOG4107TVP HD domain protein FOC88_20550 ENOG4107RN3 metallophosphoesterase FOC88_20570 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_20580 ENOG4105DF9 Lipoate-protein, ligase FOC88_20585 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC88_20590 ENOG4106AXD FOC88_20600 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC88_20620 ENOG4105ECB domain protein FOC88_20655 ENOG4105C1Q protoporphyrinogen oxidase FOC88_20670 ENOG4105BZ4 penicillin-binding protein FOC88_20675 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC88_20680 ENOG4105CKV Membrane FOC88_20685 ENOG410905X membrane-flanked domain protein FOC88_20725 ENOG4105CKV Membrane FOC88_20730 ENOG410905X membrane-flanked domain protein FOC88_20765 ENOG4105K59 histidine triad (HIT) protein FOC88_20790 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC88_20795 ENOG4105EEM helicase FOC88_20805 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_20810 ENOG4105C57 major facilitator superfamily FOC88_20825 ENOG4105CNI cell division protein FtsW FOC88_20835 ENOG4105EMN RNA polymerase sigma factor FOC88_20850 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC88_20865 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC88_20885 ENOG4108MUZ hydrolase FOC88_20935 ENOG4106D4I domain protein FOC88_20940 ENOG4107VRP DNA repair exonuclease FOC88_20995 ENOG4105BZU Histidine kinase FOC88_21000 ENOG4105BZU Histidine kinase FOC88_21005 ENOG4108MJI response regulator FOC88_21015 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_21025 ENOG4105WN5 stage II sporulation protein FOC88_21090 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC88_21105 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC88_21115 ENOG4105CMT Dihydroxyacetone kinase FOC88_21125 ENOG4105CMT Dihydroxyacetone kinase FOC88_21145 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC88_21160 ENOG4108IG5 Transcriptional regulator FOC88_21165 ENOG4107P5I polyketide synthase FOC88_21210 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_21250 ENOG4105CDU Replicative dna helicase FOC88_21335 ENOG4108MRH transcriptional regulatory protein FOC88_21345 ENOG4105CSH Transporter FOC88_21360 ENOG4108JQ7 (ABC) transporter FOC88_21370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_21440 ENOG4105DER m42 family FOC88_21470 ENOG4105CGU Enoyl-CoA hydratase FOC88_21480 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC88_21490 ENOG4106AKK s-layer domain-containing protein FOC88_21530 ENOG4105CHH sulfate transporter FOC88_21545 ENOG4105D4P Coproporphyrinogen iii oxidase FOC88_21550 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC88_21570 ENOG4107FQX Alpha-acetolactate decarboxylase FOC88_21605 ENOG410839P FOC88_21620 ENOG4105CDA abc transporter atp-binding protein FOC88_21625 ENOG4105DRP amino acid AbC transporter FOC88_21635 ENOG4105BZ1 (ABC) transporter FOC88_21640 ENOG4105BZ1 (ABC) transporter FOC88_21645 ENOG4105C26 Dehydrogenase FOC88_21655 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC88_21660 ENOG4105D5Q Arginine ornithine antiporter FOC88_21670 ENOG4105CH6 catalase FOC88_21675 ENOG4107RKG DJ-1/PfpI family FOC88_21685 ENOG4105E5W Transporter FOC88_21690 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC88_21700 ENOG4105NF4 modulator of drug activity FOC88_21725 ENOG4105KPY Small multidrug resistance protein FOC88_21740 ENOG4108YXU transcriptional regulator AsnC family FOC88_21780 ENOG4106KNT transcriptional regulator FOC88_21790 ENOG4107RWR Sodium hydrogen exchanger FOC88_21795 ENOG4105CUB amino acid FOC88_21830 ENOG4107T5V SNARE associated Golgi FOC88_21865 ENOG4105WEF catalase FOC88_21895 ENOG4105C19 ABC transporter FOC88_21900 ENOG4107RBB ABC transporter, permease FOC88_21905 ENOG41069ER domain protein FOC88_21925 ENOG4105VZJ PTS System FOC88_21930 ENOG4105VCP PTS System FOC88_21935 ENOG4105EMD TRANSCRIPTIONal FOC88_21960 ENOG4108KGH TRANSCRIPTIONal FOC88_21970 ENOG41087NI Sulfite exporter TauE/SafE FOC88_21975 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC88_21985 ENOG4105VFE sira family FOC88_21990 ENOG4105VFE sira family FOC88_21995 ENOG4107TPS domain protein FOC88_22000 ENOG4105VFE sira family FOC88_22005 ENOG4105XTG Pfam:DUF156 FOC88_22010 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC88_22020 ENOG4108TCS Glutamyl endopeptidase FOC88_22025 ENOG4105ED1 spovr family FOC88_22030 ENOG4107Y03 Nitroreductase FOC88_22050 ENOG4108B31 Spore germination protein FOC88_22085 ENOG4105C5Y PTS System FOC88_22105 ENOG4108PXI ErfK YbiS YcfS YnhG FOC88_22115 ENOG4105C7N Xanthine uracil vitamin C permease FOC88_22140 ENOG4108INS Transcriptional regulator FOC88_22190 ENOG4105DWF phosphomethylpyrimidine kinase FOC88_22195 ENOG4105D06 uba thif-type nad fad binding protein FOC88_22210 ENOG41080HI glycine oxidase FOC88_22215 ENOG4108VEU Thiamine monophosphate synthase FOC88_22225 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC88_22235 ENOG4105ETU transcriptional activator (TenA FOC88_22255 ENOG41080XQ Signal transduction protein with cbs domains FOC88_22380 ENOG4105E2Z phosphate ABC transporter (Permease FOC88_22385 ENOG4105C8U phosphate abc transporter FOC88_22390 ENOG4105CVA phosphate FOC88_22395 ENOG4105CE1 Ferrous iron transport protein b FOC88_22400 ENOG4105CE1 Ferrous iron transport protein b FOC88_22405 ENOG4105CE1 Ferrous iron transport protein b FOC88_22410 ENOG4108NHD germination protein FOC88_22425 ENOG4105E1V na solute symporter FOC88_22430 ENOG4106CAD Protein of unknown function (DUF3311) FOC88_22445 ENOG4108IQI permease FOC88_22450 ENOG4105E2S oxidase) subunit II FOC88_22455 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC88_22480 ENOG4105MA6 gCN5-related N-acetyltransferase FOC88_22495 ENOG4105C7N Xanthine uracil vitamin C permease FOC88_22500 ENOG4105C85 amino acid FOC88_22520 ENOG4105DUX Transporter FOC88_22530 ENOG4107D63 FOC88_22535 ENOG4105VZ8 Transcriptional regulator FOC88_22540 ENOG41069ER domain protein FOC88_22545 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC88_22610 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC88_22615 ENOG4105CNN ABC, transporter FOC88_22630 ENOG4108RVA ribokinase FOC88_22635 ENOG4105ETE Transcriptional regulator (LacI family FOC88_22640 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_22645 ENOG41067TZ transcriptional regulator, MarR family FOC88_22650 ENOG4105CXY transporter FOC88_22660 ENOG4108JQ7 (ABC) transporter FOC88_22665 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC88_22685 ENOG41068KF Universal stress protein FOC88_22690 ENOG4105CHH sulfate transporter FOC88_22700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_22705 ENOG4105BZU Histidine kinase FOC88_22710 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC88_22715 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC88_22735 ENOG4105GFR rna polymerase sigma factor FOC88_22750 ENOG4108IQI permease FOC88_22755 ENOG4105DRP amino acid AbC transporter FOC88_22760 ENOG4105EAD ABC transporter FOC88_22765 ENOG4105CT1 (ABC) transporter FOC88_22770 ENOG4105CDA abc transporter atp-binding protein FOC88_22775 ENOG4105BZG amino acid carrier protein FOC88_22780 ENOG4105CRN Aminoglycoside phosphotransferase FOC88_22790 ENOG4105E1K spore germination protein FOC88_22805 ENOG4105CG3 alpha amylase, catalytic region FOC88_22810 ENOG4105C5Y PTS System FOC88_22815 ENOG4107414 GntR family transcriptional regulator FOC88_22820 ENOG4105D5Q Arginine ornithine antiporter FOC88_22825 ENOG4105BZU Histidine kinase FOC88_22840 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC88_22845 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC88_22850 ENOG4107T89 von Willebrand factor, type A FOC88_22860 ENOG4105EXW epimerase dehydratase FOC88_22870 ENOG4105DMQ Methyltransferase FOC88_22875 ENOG4105E0A ABC, transporter FOC88_22880 ENOG4108IHU transport system permease protein FOC88_22885 ENOG4105DQ5 transport system permease protein FOC88_22890 ENOG4108MES Periplasmic binding protein FOC88_22895 ENOG4105DUX Transporter FOC88_22910 ENOG4105DAA L-lactate FOC88_22915 ENOG4108IJ0 Aspartate ammonia-lyase FOC88_22920 ENOG4105C37 (CBS) domain FOC88_22925 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC88_22930 ENOG4105D9N nucleoside FOC88_22935 ENOG4108KGH TRANSCRIPTIONal FOC88_22940 ENOG41073R8 VanW family FOC88_22975 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC88_22980 ENOG4105C59 p-type ATPase FOC88_22990 ENOG4105CUB amino acid FOC88_23010 ENOG4108JB9 formate dehydrogenase FOC88_23015 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC88_23020 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC88_23025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_23030 ENOG4105BZU Histidine kinase FOC88_23040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC88_23045 ENOG4108UZ3 Transporter FOC88_23055 ENOG4105C6K Malic enzyme FOC88_23065 ENOG4108MRH transcriptional regulatory protein FOC88_23090 ENOG4105US7 Histidine kinase FOC88_23095 ENOG4108STX response regulator FOC88_23100 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC88_23105 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC88_23110 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC88_23115 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC88_23120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC88_23125 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC88_23145 ENOG4105D4T Citrate transporter FOC88_23150 ENOG4108V9W transcriptional regulatory protein FOC88_23155 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC88_23165 ENOG4105DZ6 Band 7 protein FOC88_23180 ENOG4105C94 Transporter FOC88_23200 ENOG4105CYN Serine protein kinase FOC88_23205 ENOG4105BZU Histidine kinase FOC88_23210 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC88_23220 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC88_23230 ENOG4107ZQN disulfide bond FOC88_23235 ENOG4108JQC penicillin-binding protein 1A FOC88_23350 ENOG4105G5W regulator Fur family FOC88_23355 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC88_23375 ENOG4108IUW ABC transporter FOC88_23385 ENOG4105CBC glutamate synthase FOC88_23390 ENOG4107NBY Membrane FOC88_23395 ENOG4105BZ1 (ABC) transporter FOC88_23415 ENOG4106BXE FOC88_23420 ENOG4105CEN a g-specific adenine glycosylase FOC88_23425 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC88_23455 ENOG4105ECP epimerase FOC88_23460 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC88_23480 ENOG4105F1A Pyruvate formate-lyase FOC88_23500 ENOG4105C3I Nad-dependent epimerase dehydratase FOC88_23505 ENOG4107QQG Dehydrogenase FOC88_23510 ENOG4105CKK Glycosyl transferase, family 2 FOC88_23525 ENOG4108A04 Beta-lactamase FOC88_23575 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC88_23610 ENOG4105UPD Calcium Proton FOC88_23615 ENOG410606W general stress protein FOC88_23630 ENOG4107ZTW SNARE associated Golgi FOC88_23640 ENOG4105C3F Signal peptidase i FOC88_23655 ENOG4108IPJ Membrane FOC88_23660 ENOG4105C59 p-type ATPase FOC88_23665 ENOG4107U9T Pfam:Ribonuclease_BN FOC88_23675 ENOG4105KJF protein tyrosine phosphatase FOC88_23695 ENOG4108TTB tellurium resistance protein FOC88_23700 ENOG4107TS3 membrane protein, TerC FOC88_23705 ENOG4106FN3 tellurium resistance protein FOC88_23710 ENOG4106FN3 tellurium resistance protein FOC88_23715 ENOG4108N0M stress protein FOC88_23745 ENOG4105DEU major facilitator superfamily FOC88_23765 ENOG41062JF Transcriptional regulator FOC88_23795 ENOG4105C5H ABC transporter FOC88_23810 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC88_23825 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC88_23855 ENOG4105CI1 PTS System FOC88_23875 ENOG4105C5B carbamate kinase FOC88_23900 ENOG4105C8Q Methyl-accepting chemotaxis FOC88_23910 ENOG4105EAB amino acid AbC transporter FOC88_23915 ENOG4105E5Q amino acid AbC transporter FOC88_23930 ENOG4105D2S major facilitator superfamily FOC88_23935 ENOG410756H nucleotidyltransferase FOC88_23980 ENOG4106UIA FOC88_23985 ENOG4106UIA FOC88_24005 ENOG4108V5C ABC transporter FOC88_24010 ENOG4105DQ5 transport system permease protein FOC88_24015 ENOG4105EHG Permease protein FOC88_24035 ENOG4105D3R alkyl hydroperoxide reductase FOC88_24055 ENOG4105DFD Na H antiporter FOC88_24065 ENOG4105DTQ mandelate racemase muconate lactonizing FOC88_24080 ENOG4108W15 Protein of unknown function (DUF1456) FOC88_24095 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC88_24100 ENOG4105D9N nucleoside FOC88_24120 ENOG4105KPY Small multidrug resistance protein FOC88_24125 ENOG4105C26 Dehydrogenase FOC88_24135 ENOG4108JPW Aminotransferase FOC88_24140 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC88_24145 ENOG4105CBD Diacylglycerol kinase FOC88_24165 ENOG4107I77 yiaA/B two helix domain FOC88_24170 ENOG410834F Transcriptional regulator FOC88_24190 ENOG4105D01 (LipO)protein FOC88_24195 ENOG4108UMI ABC transporter, permease FOC88_24200 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC88_24205 ENOG4108W2Y isochorismatase FOC88_24235 ENOG4105C4R Atp-dependent dna helicase FOC88_24260 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC88_24270 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC88_24295 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC88_24305 ENOG4105C83 adenylosuccinate lyase FOC88_24310 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC88_24315 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC88_24335 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_24380 ENOG4108SHN Glycosyl transferase, family 2 FOC88_24400 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC88_24430 ENOG4107ZXU DSBA oxidoreductase FOC88_24455 ENOG4105BZU Histidine kinase FOC88_24465 ENOG4105C7N Xanthine uracil vitamin C permease FOC88_24485 ENOG4108TYN CAAX amino terminal protease family protein FOC88_24500 ENOG4105C5H ABC transporter FOC88_24510 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC88_24515 ENOG41072GX Peptidase M22 Glycoprotease FOC88_24520 ENOG4105K8N protein family UPF0079, ATPase FOC88_24620 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC88_24630 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC88_24635 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC88_24645 ENOG4107ZXI Rhomboid family FOC88_24660 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC88_24665 ENOG4105CPF Cell wall formation (By similarity) FOC88_24670 ENOG4108SC4 )-transporter FOC88_24680 ENOG4105ERH Fumarylacetoacetate hydrolase FOC88_24685 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC88_24715 ENOG410667J hydrolase FOC88_24720 ENOG4108JQ7 (ABC) transporter FOC88_24725 ENOG4105C3U ABC transporter FOC88_24730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_24740 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC88_24750 ENOG4108KYE ABC-2 type transporter FOC88_24755 ENOG41090VJ ABC-2 type transporter FOC88_24760 ENOG4105CJ1 ABC, transporter FOC88_24765 ENOG4105WH1 Two component transcriptional regulator luxr family FOC88_24770 ENOG4105BZU Histidine kinase FOC88_24775 ENOG4105C5H ABC transporter FOC88_24800 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC88_24805 ENOG4108RE7 deoxyribonuclease FOC88_24815 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC88_24835 ENOG4105F6E Acyl-transferase FOC88_24865 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC88_24870 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC88_24875 ENOG4105E0C molybdate abc transporter FOC88_24885 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC88_24890 ENOG4105II7 pyrroline-5-carboxylate reductase FOC88_24900 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC88_24905 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC88_24935 ENOG4108JQ7 (ABC) transporter FOC88_24940 ENOG4105C3U ABC transporter FOC88_24945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_24950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC88_24965 ENOG4105C2C drug resistance transporter, Bcr CflA FOC88_24980 ENOG4105IQ5 FAD linked oxidase domain protein FOC88_24995 ENOG4105D01 (LipO)protein FOC88_25000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC88_25005 ENOG4108UMI ABC transporter, permease FOC88_25010 ENOG4108PSK reductase FOC88_25045 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC88_25055 ENOG4105CMG Carbohydrate kinase FOC88_25065 ENOG4108VQT Alpha beta hydrolase fold protein FOC88_25085 ENOG4107U5W ybbr family FOC88_25090 ENOG4105C8B TIGR00159 family FOC88_25170 ENOG4108NMV polysaccharide deacetylase FOC88_25185 ENOG4105D1F ATP-binding protein FOC88_25215 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC88_25260 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC88_25270 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC88_25400 ENOG4105XPM ribosomal protein FOC88_25415 ENOG4107Y49 methyltransferase FOC88_25440 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC88_25455 ENOG4105QIV RNA polymerase FOC88_25460 ENOG4105M0M Tetracycline resistance protein FOC88_25465 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC88_25480 ENOG4105D7W serine acetyltransferase FOC88_25500 ENOG4105CTP PilT protein domain protein FOC88_25510 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC88_25525 ENOG4108Z0C Uvrb UvrC protein FOC88_25615 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC88_25625 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC88_25630 ENOG4105KRF dihydroneopterin aldolase FOC88_25635 ENOG4105EEI dihydropteroate synthase FOC88_25640 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC88_25645 ENOG4105DDQ anthranilate synthase FOC88_25650 ENOG4105CRQ synthase (Component I) FOC88_25655 ENOG4105C6T cysteine synthase FOC88_25670 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC88_25675 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC88_25700 ENOG41060GV RNA binding s1 domain protein FOC88_25715 ENOG4105VYY sporulation protein yabp FOC88_25720 ENOG41082I2 s4 domain protein FOC88_25725 ENOG4108IY2 MazG family FOC88_25735 ENOG4108M14 stage v sporulation protein t FOC88_25740 ENOG4108JA2 transcriptioN-repair coupling factor FOC88_25770 ENOG4105KME endoribonuclease L-psp FOC88_25775 ENOG4105DFT pur operon repressor FOC88_25790 ENOG4105W42 Veg protein FOC88_25795 ENOG4105XFA sporulation peptidase YabG FOC88_25805 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC88_25810 ENOG4105F8V Hydrolase, tatD family FOC88_25820 ENOG4105KRN Transcriptional regulator, abrb family FOC88_25825 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC88_25835 ENOG41060K3 Methyltransferase FOC88_25845 ENOG4105MA4 psp1 domain protein FOC88_25850 ENOG4105FA2 dna polymerase iii FOC88_25860 ENOG4105CXN decarboxylase FOC88_25895 ENOG41067KS pro-sigma K processing FOC88_25915 ENOG4105C6E dna polymerase iii FOC88_25925 ENOG4108Z6B deaminase FOC88_25930 ENOG4105GTG Isochorismatase FOC88_25940 ENOG4105ZMH deoxynucleoside kinase FOC88_25975 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC88_26010 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC88_26025 ENOG410848D S4 domain protein YaaA FOC88_26030 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC88_26050 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC88_26080 ENOG4107QJE Chromosome Partitioning Protein FOC88_26085 ENOG4105FA0 parb-like partition protein FOC88_26090 ENOG4108ZDA Sporulation protein YyaC FOC88_26095 ENOG4105D8X mechanosensitive ion channel FOC88_26100 ENOG4105VDK protein, conserved in bacteria FOC88_26105 ENOG4105C3G gtp-binding protein FOC88_26115 ENOG4108UUM single-stranded DNA-binding protein FOC88_26125 ENOG4108XMW Membrane FOC88_26130 ENOG4105BZR domain protein FOC88_26140 ENOG4105CDU Replicative dna helicase FOC88_26170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_26175 ENOG4105BZU Histidine kinase FOC88_26190 ENOG4105Q2H domain protein FOC88_26195 ENOG4105C0H protease FOC88_26215 ENOG4105DPN Oligoendopeptidase f FOC88_26230 ENOG4105C1J atp-dependent rna helicase FOC88_26240 ENOG4108UT2 hemolysin iii FOC88_26245 ENOG4105CMR udp-glucose 4-epimerase FOC88_26255 ENOG4105IW1 AmiS UreI transporter FOC88_26265 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC88_26280 ENOG4107RGD Major Facilitator superfamily FOC88_26285 ENOG4108HRK Histidine kinase FOC88_26290 ENOG4105DY9 regulatoR FOC88_26305 ENOG4106F5Q Membrane FOC88_26310 ENOG4105E0X reductase FOC88_26320 ENOG41067SE Tetr family transcriptional regulator FOC88_26325 ENOG4105CKK Glycosyl transferase, family 2 FOC88_26345 ENOG4105C5H ABC transporter FOC88_26350 ENOG4105JEU Glycosyl transferase, family 2 FOC88_26360 ENOG4108S4H thioesterase Superfamily protein FOC88_26370 ENOG4106YBV Methyl-accepting chemotaxis FOC88_26375 ENOG4105EN6 Membrane FOC88_26395 ENOG41079KZ Major Facilitator Superfamily FOC88_26400 ENOG4105DY9 regulatoR FOC88_26405 ENOG4105D22 carbon starvation protein FOC88_26410 ENOG4105VCD cytoplasmic protein FOC88_26415 ENOG4105BZU Histidine kinase FOC88_26420 ENOG4105DWF phosphomethylpyrimidine kinase FOC88_26425 ENOG4105BZU Histidine kinase FOC88_26430 ENOG4105WH1 Two component transcriptional regulator luxr family FOC88_26440 ENOG4108Y4K DNA-binding transcriptional activator FOC88_26465 ENOG4105D6E homoserine dehydrogenase FOC88_26480 ENOG41090WU lipolytic protein G-D-S-L family FOC88_26485 ENOG4105CJ1 ABC, transporter FOC88_26490 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC88_26500 ENOG4105VCH membrane FOC88_26505 ENOG410667J hydrolase FOC88_26515 ENOG4107SVH Potassium channel protein FOC88_26535 ENOG4108VKI Cell wall hydrolase FOC88_26550 ENOG4108IJ2 phosphate acetyltransferase FOC88_26565 ENOG4108VCI transcription factor, rsfa family FOC88_26575 ENOG4105DQ5 transport system permease protein FOC88_26580 ENOG4105EHG Permease protein FOC88_26585 ENOG4105E0A ABC, transporter FOC88_26590 ENOG4108MES Periplasmic binding protein FOC88_26595 ENOG4105DCI Phosphohydrolase FOC88_26600 ENOG41069HH 4-oxalocrotonate tautomerase FOC88_26605 ENOG4108Z4T Peptidase M50 FOC88_26610 ENOG4108XFG YwhD family FOC88_26615 ENOG4105BZ4 penicillin-binding protein FOC88_26620 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC88_26625 ENOG4107SWG transcriptional regulator MERR family FOC88_26630 ENOG4105DXB Major Facilitator superfamily FOC88_26640 ENOG4105CYW agmatinase FOC88_26660 ENOG410684U Domain of unknown function (DUF1934) FOC88_26670 ENOG4105EMN RNA polymerase sigma factor FOC88_26690 ENOG4105IIU Aminopeptidase FOC88_26700 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC88_26705 ENOG4108M15 ABC transporter FOC88_26710 ENOG4105KCT ABC transporter FOC88_26715 ENOG4105BZU Histidine kinase FOC88_26740 ENOG4105BZU Histidine kinase FOC88_26755 ENOG4105DF6 Fe-S oxidoreductase FOC88_26765 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC88_26770 ENOG4105C1G acyl-Coa dehydrogenase FOC88_26775 ENOG4105C1G acyl-Coa dehydrogenase FOC88_26815 ENOG4105CBT Fructose-1,6-bisphosphatase FOC88_26820 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC88_26840 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC88_26845 ENOG4108ZXQ stage ii sporulation protein r FOC88_26855 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC88_26870 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC88_26875 ENOG4108VGI doxx family FOC88_26890 ENOG4108YZG isomerase FOC88_26920 ENOG41062M3 atp synthase FOC88_26925 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC88_26975 ENOG4105BZU Histidine kinase FOC88_26990 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC88_26995 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC88_27020 ENOG4105D65 subunit l FOC88_27025 ENOG4105C8S subunit m FOC88_27030 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC88_27035 ENOG4106778 Protein of unknown function (DUF1146) FOC88_27055 ENOG4105DY9 regulatoR FOC88_27070 ENOG4105FRN stage II sporulation protein FOC88_27085 ENOG4107BJW polysaccharide deacetylase FOC88_27090 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC88_27120 ENOG4107VDP teichoic acid biosynthesis FOC88_27140 ENOG4105EY8 ABC transporter FOC88_27145 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC88_27165 ENOG4105CMR udp-glucose 4-epimerase FOC88_27170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_27175 ENOG4105BZU Histidine kinase FOC88_27190 ENOG4105CXY transporter FOC88_27200 ENOG4105C19 ABC transporter FOC88_27205 ENOG4107RBB ABC transporter, permease FOC88_27215 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_27245 ENOG4105C0D helicase FOC88_27250 ENOG4105KBK Zinc finger, swim domain protein FOC88_27275 ENOG41069ER domain protein FOC88_27280 ENOG4105C94 Transporter FOC88_27285 ENOG4107R8N Glycosyl transferase, family 2 FOC88_27375 ENOG4106CVF DNA replication protein FOC88_27425 ENOG4108IMY Transcriptional regulator FOC88_27505 ENOG4107QJE Chromosome Partitioning Protein FOC88_27525 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC88_27550 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC88_27630 ENOG41060SN FOC88_27660 ENOG4106CGH Phage Mu protein F like protein FOC88_27665 ENOG4108MDF Phage Portal Protein FOC88_27715 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)