locus-tag class description FOC89_00065 ENOG4108IMY Transcriptional regulator FOC89_00115 ENOG4106CVF DNA replication protein FOC89_00170 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC89_00210 ENOG4108MDF Phage Portal Protein FOC89_00215 ENOG4106CGH Phage Mu protein F like protein FOC89_00245 ENOG41060SN FOC89_00300 ENOG4105XSJ toxin secretion phage lysis holin FOC89_00325 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC89_00350 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC89_00370 ENOG4107QJE Chromosome Partitioning Protein FOC89_00390 ENOG41060AI SEC-C motif FOC89_00405 ENOG4105DUX Transporter FOC89_00450 ENOG4105KCT ABC transporter FOC89_00455 ENOG4108M15 ABC transporter FOC89_00510 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC89_00550 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC89_00630 ENOG4105K4H Nlp p60 protein FOC89_00805 ENOG4107QJE Chromosome Partitioning Protein FOC89_00830 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC89_00870 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC89_00915 ENOG4105C4R Atp-dependent dna helicase FOC89_01190 ENOG4105C2M dna polymerase I FOC89_01480 ENOG4107XK4 dna polymerase iii subunits gamma and tau FOC89_01750 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC89_01755 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC89_01820 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC89_02030 ENOG4108VXD carboxy-peptidase FOC89_02185 ENOG4105IEH endo-beta-N-acetylglucosaminidase FOC89_02270 ENOG4105MZU cell filamentation protein FOC89_02320 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC89_02325 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC89_02450 ENOG4105C2M dna polymerase I FOC89_02475 ENOG410906U SprT-like FOC89_02560 ENOG4105EQI Metal Dependent Phosphohydrolase FOC89_02635 ENOG4105D9P serine threonine protein kinase FOC89_03055 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOC89_03160 ENOG4105EQ0 Major Facilitator superfamily FOC89_03165 ENOG4108IND Tetr family transcriptional regulator FOC89_03175 ENOG41067QW Transcriptional regulator FOC89_03180 ENOG4108Z66 YbaK ebsC protein FOC89_03200 ENOG4105KVH Transcriptional regulator FOC89_03205 ENOG4108RCM Nitroreductase FOC89_03225 ENOG4108PSK reductase FOC89_03235 ENOG4105CJ1 ABC, transporter FOC89_03295 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC89_03300 ENOG4105DKQ ROK family FOC89_03305 ENOG4106UW1 Major Facilitator superfamily FOC89_03310 ENOG4108UW5 maltose o-acetyltransferase FOC89_03320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC89_03360 ENOG4105DMQ Methyltransferase FOC89_03370 ENOG4105EV4 Multidrug resistance protein mdtH FOC89_03400 ENOG4105C37 (CBS) domain FOC89_03415 ENOG4105DDN Pentapeptide repeat-containing protein FOC89_03420 ENOG4105XDF Protein of unknown function (DUF1272) FOC89_03425 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC89_03430 ENOG4105CMG Carbohydrate kinase FOC89_03435 ENOG4105C6Z Gluconate FOC89_03440 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC89_03455 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC89_03470 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC89_03490 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC89_03495 ENOG4105D4Y metalloprotease FOC89_03530 ENOG4105C44 Serine transporter FOC89_03560 ENOG4105KVH Transcriptional regulator FOC89_03565 ENOG4108TZY GntR Family Transcriptional Regulator FOC89_03570 ENOG4105D9R oxidoreductase FOC89_03575 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC89_03580 ENOG4105KVH Transcriptional regulator FOC89_03585 ENOG4105KVH Transcriptional regulator FOC89_03625 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC89_03635 ENOG4105CHR reductase FOC89_03650 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC89_03655 ENOG4105KVH Transcriptional regulator FOC89_03710 ENOG4105KAF membrAne FOC89_03735 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC89_03785 ENOG4105H3G oxidoreductase FOC89_03820 ENOG4105CIS alcohol dehydrogenase FOC89_03855 ENOG4108TN2 lmbE family FOC89_03865 ENOG4107R3E Citrate transporter FOC89_03880 ENOG4108MES Periplasmic binding protein FOC89_03885 ENOG4105EHG Permease protein FOC89_03890 ENOG4105DQ5 transport system permease protein FOC89_03895 ENOG4105NX3 Membrane FOC89_03900 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC89_03920 ENOG4107CUJ Protein of unknown function (DUF2690) FOC89_03930 ENOG4107V2S Transcriptional regulator FOC89_03950 ENOG4105C98 muts2 protein FOC89_03960 ENOG4105E5K Alpha-amylase FOC89_03965 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC89_03970 ENOG4105DPN Oligoendopeptidase f FOC89_03975 ENOG4108A04 Beta-lactamase FOC89_04005 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC89_04030 ENOG41082BM Transcriptional regulator, arsr family FOC89_04035 ENOG4105CIS alcohol dehydrogenase FOC89_04085 ENOG4105RHY Pfam:UPF0157 FOC89_04095 ENOG4105C09 Bile acid FOC89_04100 ENOG4105CQB FAD linked oxidase domain protein FOC89_04120 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC89_04130 ENOG4105K64 Glycosyl transferase, family 2 FOC89_04135 ENOG4105E39 Enoyl-CoA hydratase FOC89_04145 ENOG4105KT7 mgtC SapB transporter FOC89_04160 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC89_04165 ENOG41073R8 VanW family FOC89_04175 ENOG4108R1P FOC89_04195 ENOG4105VEQ Cold shock protein FOC89_04215 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC89_04255 ENOG4105DR5 peptidase FOC89_04270 ENOG4107YXZ hydrolase, family 25 FOC89_04275 ENOG4105DR5 peptidase FOC89_04330 ENOG410904N short-chain dehydrogenase reductase FOC89_04340 ENOG4106IQC argininosuccinate lyase FOC89_04355 ENOG4108IA2 Sodium pantothenate symporter FOC89_04360 ENOG4105RG0 Membrane FOC89_04365 ENOG4105C26 Dehydrogenase FOC89_04370 ENOG4105CHR reductase FOC89_04380 ENOG4105EWU Squalene--hopene cyclase FOC89_04390 ENOG4105FR1 rard protein FOC89_04395 ENOG410696E Membrane FOC89_04410 ENOG4105D1F ATP-binding protein FOC89_04420 ENOG4108ZAF Molybdopterin FOC89_04425 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC89_04430 ENOG4105D06 uba thif-type nad fad binding protein FOC89_04435 ENOG4105TMB Formate nitrite transporter FOC89_04445 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC89_04450 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC89_04460 ENOG4108JB9 formate dehydrogenase FOC89_04470 ENOG4105E1K spore germination protein FOC89_04535 ENOG4107QJT sodium dicarboxylate symporter FOC89_04540 ENOG4108KGH TRANSCRIPTIONal FOC89_04550 ENOG4105EMN RNA polymerase sigma factor FOC89_04570 ENOG4105CIG ABC transporter FOC89_04580 ENOG4105D9R oxidoreductase FOC89_04590 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC89_04595 ENOG4105K4P CoA-binding domain protein FOC89_04600 ENOG4105C0H protease FOC89_04605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_04615 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC89_04625 ENOG4105W8X HesB YadR YfhF-family protein FOC89_04655 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC89_04660 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC89_04670 ENOG4108JJA ABC, transporter FOC89_04675 ENOG4108I0Z Aconitate hydratase FOC89_04715 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC89_04735 ENOG4107F3J Amp-dependent synthetase and ligase FOC89_04740 ENOG4107ZYJ bioY protein FOC89_04745 ENOG4105CEY Amp-dependent synthetase and ligase FOC89_04795 ENOG4107AYK membrAne FOC89_04805 ENOG4105BZU Histidine kinase FOC89_04810 ENOG4105FBA Phospholipase Carboxylesterase FOC89_04815 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC89_04820 ENOG4105CK7 Sodium proline symporter FOC89_04825 ENOG4105CBC glutamate synthase FOC89_04830 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC89_04835 ENOG4108VJ1 Transcriptional regulator (CarD family FOC89_04840 ENOG4108903 Formimidoylglutamase FOC89_04905 ENOG4107QIV Cytochrome c biogenesis protein FOC89_04925 ENOG4105CJ1 ABC, transporter FOC89_04935 ENOG4107RSM transcriptional regulator FOC89_04945 ENOG41067MG lrgb family FOC89_04970 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC89_04985 ENOG4105BZ1 (ABC) transporter FOC89_04990 ENOG4105BZ1 (ABC) transporter FOC89_05010 ENOG4105D7V transposase FOC89_05025 ENOG4105D5T phosphonate abc transporter FOC89_05030 ENOG4108HW3 (ABC) transporter FOC89_05035 ENOG4105CGH 5'-nucleotidase FOC89_05045 ENOG4108SVB resolvase FOC89_05065 ENOG4105K7K Transcriptional regulator FOC89_05095 ENOG4105C5F glutamine synthetase FOC89_05100 ENOG4105KV4 Transcriptional regulator FOC89_05105 ENOG4105CXI aluminum resistance protein FOC89_05110 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC89_05115 ENOG4105EN6 Membrane FOC89_05120 ENOG4106F1P AAA ATPase, central domain protein FOC89_05150 ENOG41069ER domain protein FOC89_05155 ENOG4105DM4 PTS System FOC89_05160 ENOG4105DE4 1-phosphofructokinase FOC89_05165 ENOG4105E98 transcriptional regulator DeoR family FOC89_05170 ENOG4107QW4 alcohol dehydrogenase FOC89_05175 ENOG4108SJC Membrane FOC89_05185 ENOG4105C85 amino acid FOC89_05205 ENOG4105TMB Formate nitrite transporter FOC89_05210 ENOG4105K70 DNA-binding protein FOC89_05220 ENOG4105C59 p-type ATPase FOC89_05225 ENOG410681U heavy metal transport detoxification protein FOC89_05230 ENOG4105VPX protein, conserved in bacteria FOC89_05240 ENOG4105NIV Esterase FOC89_05245 ENOG4105E0A ABC, transporter FOC89_05265 ENOG4105CGK Exodeoxyribonuclease III FOC89_05275 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC89_05280 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC89_05310 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC89_05315 ENOG4105BZU Histidine kinase FOC89_05330 ENOG41067MG lrgb family FOC89_05350 ENOG4107YEI lmbE family FOC89_05375 ENOG4105F0V Cell wall hydrolase FOC89_05380 ENOG4107R6R udp-galactopyranose mutase FOC89_05385 ENOG4105E0M Sulfatase FOC89_05390 ENOG410890F Dynamin family FOC89_05400 ENOG4107QHE Choloylglycine hydrolase FOC89_05430 ENOG4105DQU oxidoreductase, subunit beta FOC89_05435 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC89_05440 ENOG4108IGT Dipeptidase FOC89_05445 ENOG4105MCT stage V sporulation protein S FOC89_05450 ENOG4105D48 metallophosphoesterase FOC89_05475 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC89_05490 ENOG4105XZV Protein of unknown function (DUF3243) FOC89_05495 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC89_05515 ENOG4105UIB (ABC) transporter FOC89_05520 ENOG4108JQ9 ABC transporter FOC89_05525 ENOG4105DIH basic membrane FOC89_05530 ENOG4105FDP GntR family transcriptional regulator FOC89_05535 ENOG4107QZI cell division protein FtsK FOC89_05545 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC89_05555 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC89_05565 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC89_05570 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC89_05575 ENOG4105E35 Dipicolinate synthase subunit A FOC89_05585 ENOG4105C1V Peptidase, M16 FOC89_05605 ENOG4105DTN riboflavin biosynthesis protein ribF FOC89_05610 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC89_05620 ENOG4105W7A Protein of unknown function (DUF503) FOC89_05630 ENOG4105VHM ribosomal protein FOC89_05635 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC89_05640 ENOG4105CHV Transcription elongation factor NusA FOC89_05650 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC89_05660 ENOG4105DZP Membrane-associated zinc metalloprotease FOC89_05670 ENOG4105KNE Phosphatidate cytidylyltransferase FOC89_05715 ENOG4108HE4 integrase family FOC89_05725 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC89_05730 ENOG4105C79 DNA protecting protein DprA FOC89_05735 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC89_05750 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC89_05775 ENOG4105VB6 UPF0109 protein FOC89_05795 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC89_05800 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC89_05815 ENOG4105CHR reductase FOC89_05820 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC89_05835 ENOG4105CB5 ATP-dependent DNA helicase recG FOC89_05840 ENOG4105DP4 dak2 domain fusion protein ylov FOC89_05845 ENOG4108ZAA Alkaline-shock protein FOC89_05860 ENOG4105FJ0 thiamine FOC89_05865 ENOG4105DJV ribulose-phosphate 3-epimerase FOC89_05870 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC89_05875 ENOG4105D9P serine threonine protein kinase FOC89_05880 ENOG4108ZF3 Phosphatase FOC89_05890 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC89_05900 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC89_05905 ENOG4105C25 Primosomal protein n' FOC89_05910 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC89_05930 ENOG4105DSJ YicC domain protein FOC89_05945 ENOG4105DC7 peptidase M24 FOC89_06030 ENOG4105C34 Pseudouridine synthase FOC89_06055 ENOG4105DBK s4 domain protein FOC89_06060 ENOG41067XK integral membrane protein FOC89_06070 ENOG4105DFA alanine racemase domain protein FOC89_06075 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC89_06080 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC89_06090 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC89_06100 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC89_06105 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC89_06110 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC89_06115 ENOG4105D4A Cell wall formation (By similarity) FOC89_06125 ENOG4105CNI cell division protein FtsW FOC89_06140 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC89_06145 ENOG4105CJN penicillin-binding protein FOC89_06150 ENOG4105CJN penicillin-binding protein FOC89_06155 ENOG41068DC Essential cell division protein (By similarity) FOC89_06190 ENOG4105KNH Nucleic acid-binding protein FOC89_06200 ENOG41063PX domain protein FOC89_06205 ENOG4105D78 K07001 NTE family protein FOC89_06210 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC89_06220 ENOG4106H78 methyltransferase FOC89_06240 ENOG4107TB6 phosphoglycerate mutase FOC89_06255 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC89_06305 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC89_06310 ENOG4105CNI cell division protein FtsW FOC89_06325 ENOG4108IAB Phoh family FOC89_06345 ENOG4105QA2 FOC89_06350 ENOG4105CI3 gtp-binding protein typa FOC89_06360 ENOG4105ECY inositol monophosphatase FOC89_06380 ENOG4105CXN decarboxylase FOC89_06430 ENOG4105CPP Dehydrogenase, E1 component FOC89_06445 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC89_06450 ENOG4108X4Q Hydrolase FOC89_06460 ENOG4105CN5 Metallo-Beta-Lactamase FOC89_06465 ENOG4107ZYR domain protein FOC89_06500 ENOG4108XRC Protein of unknown function (DUF458) FOC89_06510 ENOG4107IN1 Protein of unknown function (DUF1797) FOC89_06525 ENOG4105EPM Diguanylate phosphodiesterase FOC89_06530 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC89_06545 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC89_06555 ENOG4105UIN FOC89_06610 ENOG4108HGU Histidine kinase FOC89_06620 ENOG4105CHM Aminotransferase FOC89_06625 ENOG4105FKQ transcriptional regulator FOC89_06630 ENOG4105EG2 ABC transporter, permease FOC89_06640 ENOG4107FKK extracellular solute-binding protein family 1 FOC89_06650 ENOG4105CG3 alpha amylase, catalytic region FOC89_06695 ENOG4105CHU acetyl-coa acetyltransferase FOC89_06735 ENOG4105DTD Dehydrogenase FOC89_06755 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC89_06795 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC89_06800 ENOG4106TD9 Diguanylate cyclase FOC89_06820 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC89_06835 ENOG4105CID antiterminator FOC89_06855 ENOG4105CE4 GlcNAc 6-P deacetylase FOC89_06890 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC89_06895 ENOG4105PTM secreted protein FOC89_06900 ENOG4105J7I hydrolase FOC89_06910 ENOG4105G6R Stage v sporulation protein ae FOC89_06920 ENOG4105CZ3 stage V sporulation protein ad FOC89_06925 ENOG41090VF Stage v sporulation protein ac FOC89_06945 ENOG4105C8J )-transporter FOC89_06950 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC89_06960 ENOG41082AN stage II sporulation protein FOC89_06965 ENOG4105DZ1 carboxypeptidase FOC89_06970 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC89_06975 ENOG4105DVE abc transporter atp-binding protein FOC89_07010 ENOG4105D7N magnesium and cobalt transport protein CorA FOC89_07035 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC89_07045 ENOG4105I3K Ferric uptake regulator, Fur family FOC89_07050 ENOG4105MZ9 stage II sporulation protein m FOC89_07070 ENOG4105CPC Aldo Keto reductase FOC89_07080 ENOG4105RHY Pfam:UPF0157 FOC89_07100 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC89_07110 ENOG4105ETE Transcriptional regulator (LacI family FOC89_07115 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC89_07135 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC89_07140 ENOG4108R6K riboflavin synthase, subunit alpha FOC89_07165 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC89_07170 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC89_07185 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC89_07195 ENOG4105DFD Na H antiporter FOC89_07200 ENOG4105CGH 5'-nucleotidase FOC89_07240 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC89_07255 ENOG4108IXY short-chain dehydrogenase reductase FOC89_07260 ENOG41069FQ Metallo-beta-lactamase superfamily FOC89_07265 ENOG4105II7 pyrroline-5-carboxylate reductase FOC89_07270 ENOG4105EJQ L-serine dehydratase FOC89_07295 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC89_07305 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC89_07310 ENOG4105D9U N-acetyltransferase FOC89_07325 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC89_07330 ENOG4108QEG Membrane FOC89_07335 ENOG4105CDA abc transporter atp-binding protein FOC89_07340 ENOG4105E5Q amino acid AbC transporter FOC89_07345 ENOG4108HW3 (ABC) transporter FOC89_07355 ENOG4105G7B Protein of unknown function (DUF2992) FOC89_07360 ENOG4105E09 nadh pyrophosphatase FOC89_07370 ENOG4105C7S Dehydrogenase FOC89_07375 ENOG4105CPP Dehydrogenase, E1 component FOC89_07395 ENOG4107RDP Dehydrogenase FOC89_07405 ENOG4108JUB Transcriptional regulator FOC89_07415 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC89_07430 ENOG4107QQR Sporulation FOC89_07435 ENOG4105S1Z Stage IV sporulation protein B FOC89_07440 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC89_07450 ENOG4105DX0 Hemolysin A FOC89_07460 ENOG4105CTB Polyprenyl synthetase FOC89_07485 ENOG4108ZSR alkaline shock protein FOC89_07490 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC89_07515 ENOG410644B Stage III sporulation protein af FOC89_07525 ENOG4105KQ4 Stage iii sporulation protein ad FOC89_07530 ENOG4108CQH stage III sporulation protein AC FOC89_07535 ENOG4105KR5 Stage iii sporulation protein FOC89_07540 ENOG4105CD2 stage iii sporulation protein aa FOC89_07565 ENOG4105DC7 peptidase M24 FOC89_07580 ENOG4105CBJ Metal-dependent enzyme FOC89_07590 ENOG4107YBY Hydrolase FOC89_07610 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC89_07615 ENOG4105WZW rhodanese family FOC89_07635 ENOG41080TC multidrug resistance protein FOC89_07670 ENOG4105CJ1 ABC, transporter FOC89_07675 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC89_07705 ENOG4105C0D helicase FOC89_07825 ENOG4105C3R Methionine synthase FOC89_07835 ENOG4105C28 cystathionine FOC89_07840 ENOG4105C28 cystathionine FOC89_07860 ENOG4105C5X domain protein FOC89_07870 ENOG4105DKQ ROK family FOC89_07880 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC89_07895 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC89_07905 ENOG4105E2Z phosphate ABC transporter (Permease FOC89_07910 ENOG4105C8U phosphate abc transporter FOC89_07915 ENOG4105PWN phosphate abc transporter FOC89_07920 ENOG4107RF6 penicillin-binding protein FOC89_07930 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC89_07955 ENOG4105N80 Ferric uptake regulator, Fur family FOC89_07965 ENOG4105FDK ABC transporter FOC89_07970 ENOG4108JYZ YitT family FOC89_07975 ENOG41069ZM Protein of unknown function (DUF2624) FOC89_08000 ENOG4105EGD dinuclear metal center protein, YbgI family FOC89_08015 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC89_08020 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC89_08050 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC89_08055 ENOG4105KG3 cytidine deaminase FOC89_08060 ENOG4107YR5 Diacylglycerol kinase FOC89_08070 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC89_08075 ENOG4105C9A Phoh family FOC89_08085 ENOG41068P3 sporulation protein YqfC FOC89_08090 ENOG4105KTH gatB Yqey FOC89_08100 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC89_08105 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC89_08135 ENOG4105CSA Coproporphyrinogen iii oxidase FOC89_08140 ENOG4105KVH Transcriptional regulator FOC89_08165 ENOG4105TQK DNA polymerase iii, delta' subunit FOC89_08175 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC89_08180 ENOG4108UK2 deaminase FOC89_08185 ENOG4105KQC Competence protein FOC89_08195 ENOG4105DXX methyltransferase FOC89_08205 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC89_08215 ENOG410812S Rna-binding protein FOC89_08225 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC89_08230 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC89_08245 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC89_08265 ENOG4108TVJ Nitroreductase FOC89_08280 ENOG4105G6Z alkaline phosphatase FOC89_08290 ENOG4108MUZ hydrolase FOC89_08325 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC89_08330 ENOG4105MIR Phenylalanine 4-monooxygenase FOC89_08340 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC89_08380 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC89_08385 ENOG4108V5C ABC transporter FOC89_08395 ENOG4105C0A alcohol dehydrogenase FOC89_08400 ENOG4105C28 cystathionine FOC89_08430 ENOG4107XRG penicillin-binding protein FOC89_08445 ENOG4105CFP Peptidase U32 FOC89_08450 ENOG4105XYU peptidase (U32 family) FOC89_08460 ENOG4105HHA aminodeoxychorismate lyase FOC89_08490 ENOG4105C02 permease FOC89_08505 ENOG41060CR FOC89_08510 ENOG4105C7H Helicase, RecD TraA family FOC89_08525 ENOG4105C3J Cysteine desulfurase FOC89_08535 ENOG4105D1H recombination factor protein RarA FOC89_08540 ENOG4108VCI transcription factor, rsfa family FOC89_08545 ENOG4105CUZ uba thif-type nad fad binding protein FOC89_08575 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC89_08585 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC89_08590 ENOG41076HS cation diffusion facilitator family transporter FOC89_08595 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC89_08605 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC89_08610 ENOG4108QG2 Membrane FOC89_08620 ENOG4105VIE preprotein translocase, subunit YajC FOC89_08635 ENOG41061AI Protein of unknown function (DUF2905) FOC89_08650 ENOG4108HUF Transporter FOC89_08680 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC89_08685 ENOG4108IYU L-aspartate oxidase FOC89_08700 ENOG4108RPX mosc domain containing protein FOC89_08705 ENOG4105CQC Prephenate dehydratase FOC89_08725 ENOG4105EWM Histidine kinase FOC89_08750 ENOG4105X36 (ribosomal) protein FOC89_08760 ENOG4105C03 ribonuclease FOC89_08775 ENOG4107QMS site-determining protein FOC89_08795 ENOG4105DFF Rod shape-determining protein mreb FOC89_08815 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC89_08820 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC89_08830 ENOG41068KH stage VI sporulation protein D FOC89_08840 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC89_08865 ENOG4105K56 Transcriptional regulator FOC89_08885 ENOG4108IUQ atp-dependent protease FOC89_08915 ENOG4108QCI YvbH-like oligomerisation region FOC89_08935 ENOG4105M59 Phosphodiesterase, mj0936 family FOC89_08950 ENOG4108XJQ germination protein FOC89_08960 ENOG4108PCX Major Facilitator FOC89_08970 ENOG4105KBX Transcriptional regulator, TetR family FOC89_08985 ENOG4105PFC Transcriptional regulator FOC89_09000 ENOG4105DZC cytosine deaminase FOC89_09005 ENOG4105DZC cytosine deaminase FOC89_09010 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC89_09015 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC89_09030 ENOG4108JQ7 (ABC) transporter FOC89_09035 ENOG4108HRK Histidine kinase FOC89_09040 ENOG4105DY9 regulatoR FOC89_09050 ENOG41067S9 phage shock protein C, PspC FOC89_09055 ENOG4108JCI Transcriptional regulator FOC89_09065 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC89_09070 ENOG4108Z40 Transcriptional regulator FOC89_09075 ENOG4105RHA ABC transporter, permease FOC89_09080 ENOG4108IUX (ABC) transporter FOC89_09085 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC89_09090 ENOG4105ER2 Ompa motb domain protein FOC89_09095 ENOG4105E14 MotA TolQ exbB proton channel FOC89_09100 ENOG4108VXD carboxy-peptidase FOC89_09110 ENOG4105E33 succinate dehydrogenase FOC89_09120 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC89_09135 ENOG4105K63 Thioredoxin FOC89_09140 ENOG4105C10 Electron transfer flavoprotein FOC89_09145 ENOG4105BZJ Electron transfer flavoprotein FOC89_09150 ENOG41060WC Enoyl-CoA hydratase FOC89_09155 ENOG4107Z3H Transcriptional regulator, TetR family FOC89_09160 ENOG4105CEY Amp-dependent synthetase and ligase FOC89_09170 ENOG4105J76 Periplasmic binding protein FOC89_09175 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC89_09215 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC89_09230 ENOG4105DR4 Methyltransferase FOC89_09245 ENOG4105KFN sortase, SrtB family FOC89_09250 ENOG4105E0A ABC, transporter FOC89_09265 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC89_09275 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC89_09285 ENOG4105FE9 pseudouridine synthase FOC89_09295 ENOG4105DCG PHP domain protein FOC89_09345 ENOG4108RWN rrna methyltransferase FOC89_09380 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC89_09385 ENOG4105CW7 secretion protein, HlyD family FOC89_09390 ENOG4108JGH Tetr family transcriptional regulator FOC89_09395 ENOG4105CN9 Peptidase m42 family protein FOC89_09420 ENOG4105C22 threonyL-tRNA synthetase FOC89_09425 ENOG4108TDW sporulation protein YtxC FOC89_09450 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC89_09455 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC89_09470 ENOG4105C2M dna polymerase I FOC89_09475 ENOG4105BZU Histidine kinase FOC89_09480 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC89_09500 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC89_09505 ENOG4105BZN citrate synthase FOC89_09515 ENOG4108REF Sporulation integral membrane protein ytvi FOC89_09520 ENOG4105FS0 cytoplasmic membrane protein FOC89_09545 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC89_09550 ENOG4105C6K Malic enzyme FOC89_09555 ENOG4105C0B DNA polymerase III (alpha subunit) FOC89_09560 ENOG4105VV2 FOC89_09570 ENOG4105SFS phosphoesterase RecJ domain protein FOC89_09605 ENOG4105DC7 peptidase M24 FOC89_09630 ENOG4105D7V transposase FOC89_09655 ENOG4105Z7P Acetyltransferase (GNAT) family FOC89_09660 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC89_09670 ENOG4105VZ8 Transcriptional regulator FOC89_09690 ENOG4107YZX Universal stress protein FOC89_09730 ENOG4108JYZ YitT family FOC89_09760 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC89_09765 ENOG4105KBJ sporulation protein ytfj FOC89_09780 ENOG4105EFZ amidohydrolase FOC89_09790 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC89_09815 ENOG4106KR7 LysR family Transcriptional regulator FOC89_09825 ENOG4105U5Y Transcriptional regulator FOC89_09835 ENOG4105C28 cystathionine FOC89_09865 ENOG4105EMN RNA polymerase sigma factor FOC89_09880 ENOG4105F1V Acetoin utilization protein FOC89_09885 ENOG4105W87 Cbs domain FOC89_09890 ENOG4105DGU Histone deacetylase FOC89_09895 ENOG4106HB6 Alpha beta hydrolase FOC89_09905 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC89_09915 ENOG4107SNB ankyrin repeat protein YahD FOC89_09920 ENOG4105EP9 oxidoreductase FOC89_09950 ENOG4105ETE Transcriptional regulator (LacI family FOC89_09970 ENOG4105C88 aminopeptidase FOC89_10000 ENOG4108IPJ Membrane FOC89_10030 ENOG4108VDD TRNA binding domain protein FOC89_10060 ENOG4105C8F Beta-lactamase domain protein FOC89_10075 ENOG4108V15 phosphotransferase enzyme family FOC89_10080 ENOG4108IUM Glycogen debranching enzyme FOC89_10090 ENOG4107QSE Dipeptidase FOC89_10095 ENOG4105YW5 deoR family transcriptional regulator FOC89_10110 ENOG4105CBX hi0933 family FOC89_10145 ENOG4108VJ1 Transcriptional regulator (CarD family FOC89_10150 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC89_10170 ENOG4108ZAF Molybdopterin FOC89_10175 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC89_10180 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC89_10190 ENOG4105D06 uba thif-type nad fad binding protein FOC89_10195 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC89_10215 ENOG41085GJ domain protein FOC89_10225 ENOG4105DWV Homoserine O-trans-acetylase FOC89_10235 ENOG4108B31 Spore germination protein FOC89_10265 ENOG410605W Major Facilitator FOC89_10270 ENOG4107S91 Sodium hydrogen exchanger FOC89_10275 ENOG4105NCW Trka-c domain protein FOC89_10290 ENOG4105C19 ABC transporter FOC89_10310 ENOG4105N5T Radical SAM Protein FOC89_10320 ENOG4105DA5 (ABC) transporter FOC89_10350 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC89_10355 ENOG4108Z0R Transferase FOC89_10360 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC89_10365 ENOG4105BZF Glycosyl transferase (Group 1 FOC89_10375 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC89_10430 ENOG4105EGD dinuclear metal center protein, YbgI family FOC89_10435 ENOG4105BZU Histidine kinase FOC89_10440 ENOG4105BZU Histidine kinase FOC89_10445 ENOG4107S9D Alpha beta hydrolase FOC89_10450 ENOG4107T7U Sulfatase FOC89_10465 ENOG4105D2X ABC transporter substrate-binding protein FOC89_10475 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC89_10490 ENOG4107XGZ Hydrolase FOC89_10535 ENOG4108V2W Carbonate dehydratase FOC89_10540 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC89_10545 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC89_10590 ENOG41087YS Phage shock protein A FOC89_10620 ENOG4105BZU Histidine kinase FOC89_10625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_10650 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC89_10655 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC89_10680 ENOG4107ZTW SNARE associated Golgi FOC89_10695 ENOG4105C19 ABC transporter FOC89_10700 ENOG41086D8 Transcriptional regulator FOC89_10765 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC89_10795 ENOG4105DTQ mandelate racemase muconate lactonizing FOC89_10805 ENOG4108IPT Naphthoate synthase FOC89_10810 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC89_10815 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC89_10820 ENOG4105E4F Isochorismate synthase FOC89_10825 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC89_10835 ENOG4105VEQ Cold shock protein FOC89_10895 ENOG4105JVQ RNA Polymerase FOC89_10990 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC89_11025 ENOG4105KT7 mgtC SapB transporter FOC89_11030 ENOG4107PBV potassium channel FOC89_11045 ENOG4105WG9 Conserved Protein FOC89_11055 ENOG4105CHM Aminotransferase FOC89_11060 ENOG4108ZB6 transcriptional regulator AsnC family FOC89_11065 ENOG4105C5I Dehydrogenase FOC89_11070 ENOG4108MUZ hydrolase FOC89_11080 ENOG4105C87 Aminotransferase class I and II FOC89_11095 ENOG4105Y38 Kinase-associated protein B FOC89_11105 ENOG4107R3E Citrate transporter FOC89_11125 ENOG4105KA0 thioesterase Superfamily protein FOC89_11145 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC89_11165 ENOG41069ER domain protein FOC89_11180 ENOG4105CEP NADH dehydrogenase FOC89_11210 ENOG4105EWC Purine nucleoside phosphorylase FOC89_11225 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC89_11250 ENOG4108JJA ABC, transporter FOC89_11255 ENOG4105C4B ABC transporter, permease FOC89_11260 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC89_11285 ENOG41083MR nifu domain-containing protein FOC89_11300 ENOG4108W5N phosphatidylglycerophosphatase a FOC89_11310 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC89_11320 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC89_11335 ENOG4105CBT Fructose-1,6-bisphosphatase FOC89_11350 ENOG4105MMD transcriptional regulator FOC89_11355 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC89_11360 ENOG4107TXC Transcriptional regulator FOC89_11365 ENOG41090T1 Membrane FOC89_11390 ENOG4105FAA peptidase M23 FOC89_11400 ENOG4105KZD Domain of unknown function (DUF1805) FOC89_11405 ENOG4107R8B 5'-nucleotidase FOC89_11410 ENOG4105DIW FeS assembly protein SUFB FOC89_11415 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC89_11420 ENOG4105C9B Cysteine desulfurase FOC89_11425 ENOG4105JRK feS assembly protein SufD FOC89_11430 ENOG4105C3K feS assembly ATPase SufC FOC89_11435 ENOG4105D01 (LipO)protein FOC89_11440 ENOG4105D01 (LipO)protein FOC89_11445 ENOG4108UMI ABC transporter, permease FOC89_11475 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC89_11555 ENOG4108IMY Transcriptional regulator FOC89_11565 ENOG4108W8B Beta-lactamase domain protein FOC89_11570 ENOG4105C1G acyl-Coa dehydrogenase FOC89_11575 ENOG4105CHU acetyl-coa acetyltransferase FOC89_11590 ENOG4105DZ1 carboxypeptidase FOC89_11610 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC89_11630 ENOG4108SUT Major Facilitator Superfamily FOC89_11635 ENOG4107R7I amino acid FOC89_11645 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC89_11655 ENOG4107AYK membrAne FOC89_11690 ENOG4107ZTW SNARE associated Golgi FOC89_11700 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC89_11705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_11710 ENOG4105BZU Histidine kinase FOC89_11730 ENOG4105C8Q Methyl-accepting chemotaxis FOC89_11735 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC89_11740 ENOG4105VG1 fes assembly suf system protein FOC89_11745 ENOG4105D4Y metalloprotease FOC89_11765 ENOG4107S91 Sodium hydrogen exchanger FOC89_11770 ENOG4105NCW Trka-c domain protein FOC89_11780 ENOG4108RMU ferritin dps family protein FOC89_11795 ENOG4108URH decarboxylase FOC89_11815 ENOG4105D9N nucleoside FOC89_11820 ENOG4105D9N nucleoside FOC89_11830 ENOG4108RYK Nad-dependent epimerase dehydratase FOC89_11850 ENOG4105CV8 reductase FOC89_11855 ENOG4105F27 Major Facilitator FOC89_11860 ENOG4105KVH Transcriptional regulator FOC89_11875 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC89_11880 ENOG4105D4A Cell wall formation (By similarity) FOC89_11905 ENOG4105C8Q Methyl-accepting chemotaxis FOC89_11935 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC89_11955 ENOG4108IPW abc transporter atp-binding protein FOC89_11960 ENOG4105CM4 permease protein FOC89_11975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_12035 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC89_12045 ENOG4105XZU Preprotein translocase, subunit SecG FOC89_12050 ENOG41067MG lrgb family FOC89_12100 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC89_12120 ENOG41090VF Stage v sporulation protein ac FOC89_12125 ENOG4105CZ3 stage V sporulation protein ad FOC89_12140 ENOG4105H67 Protein of unknown function (DUF421) FOC89_12150 ENOG4105KRI phosphocarrier protein (HPr FOC89_12160 ENOG4105CHW UPF0052 protein FOC89_12170 ENOG4108Z4K mutator MutT protein FOC89_12180 ENOG4105C3M thioredoxin reductase FOC89_12190 ENOG4108S4C acetyltransferase FOC89_12210 ENOG41086DT Membrane protein of unknown function FOC89_12220 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC89_12225 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC89_12240 ENOG4107TXC Transcriptional regulator FOC89_12265 ENOG4105HMI Membrane FOC89_12270 ENOG4105DUM transcriptional regulator, lysR family FOC89_12280 ENOG4108WS4 fmn reductase FOC89_12295 ENOG4105BZ1 (ABC) transporter FOC89_12305 ENOG4105CN1 protease FOC89_12310 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC89_12315 ENOG4105CAK Cell division ATP-binding protein ftsE FOC89_12335 ENOG4105MS2 ribosomal subunit Interface protein FOC89_12340 ENOG4105VEQ Cold shock protein FOC89_12345 ENOG41081UC Inherit from COG: Competence protein FOC89_12360 ENOG4105KVH Transcriptional regulator FOC89_12370 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC89_12375 ENOG4108KGH TRANSCRIPTIONal FOC89_12380 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC89_12385 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC89_12390 ENOG4105ESV Glycosyl transferase, family 4 FOC89_12400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC89_12420 ENOG4105F8D glycoside hydrolase family 4 FOC89_12425 ENOG4105VCP PTS System FOC89_12430 ENOG4105CK1 PTS System FOC89_12440 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC89_12450 ENOG4105VCP PTS System FOC89_12460 ENOG4105VZJ PTS System FOC89_12475 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC89_12480 ENOG4105ECB domain protein FOC89_12485 ENOG4107RSM transcriptional regulator FOC89_12520 ENOG4105DAA L-lactate FOC89_12530 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC89_12540 ENOG4105E0M Sulfatase FOC89_12565 ENOG4107R8N Glycosyl transferase, family 2 FOC89_12570 ENOG4105C94 Transporter FOC89_12575 ENOG41069ER domain protein FOC89_12600 ENOG4105KBK Zinc finger, swim domain protein FOC89_12605 ENOG4105C0D helicase FOC89_12635 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC89_12650 ENOG4107RBB ABC transporter, permease FOC89_12655 ENOG4105C19 ABC transporter FOC89_12675 ENOG4105CXY transporter FOC89_12690 ENOG4105BZU Histidine kinase FOC89_12695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_12700 ENOG4105CMR udp-glucose 4-epimerase FOC89_12715 ENOG4105CMR udp-glucose 4-epimerase FOC89_12720 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC89_12745 ENOG4105D3Q Sugar transferase FOC89_12750 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC89_12755 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC89_12760 ENOG4107YJ4 chain length determinant protein FOC89_12765 ENOG4105HTX biosynthesis protein FOC89_12770 ENOG4107YJ4 chain length determinant protein FOC89_12785 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC89_12795 ENOG4105FRN stage II sporulation protein FOC89_12810 ENOG4105DY9 regulatoR FOC89_12830 ENOG4106778 Protein of unknown function (DUF1146) FOC89_12835 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC89_12840 ENOG4105C8S subunit m FOC89_12845 ENOG4105D65 subunit l FOC89_12870 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC89_12875 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC89_12890 ENOG4105BZU Histidine kinase FOC89_12940 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC89_12945 ENOG41062M3 atp synthase FOC89_12975 ENOG4108YZG isomerase FOC89_12990 ENOG4108VGI doxx family FOC89_12995 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC89_13010 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC89_13020 ENOG4108ZXQ stage ii sporulation protein r FOC89_13025 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC89_13045 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC89_13050 ENOG4105CBT Fructose-1,6-bisphosphatase FOC89_13090 ENOG4105C1G acyl-Coa dehydrogenase FOC89_13095 ENOG4105C1G acyl-Coa dehydrogenase FOC89_13100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC89_13110 ENOG4105DF6 Fe-S oxidoreductase FOC89_13125 ENOG4105BZU Histidine kinase FOC89_13155 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC89_13165 ENOG4105IIU Aminopeptidase FOC89_13185 ENOG4105EMN RNA polymerase sigma factor FOC89_13195 ENOG410684U Domain of unknown function (DUF1934) FOC89_13215 ENOG4105CYW agmatinase FOC89_13225 ENOG4105DXB Major Facilitator superfamily FOC89_13230 ENOG4107SWG transcriptional regulator MERR family FOC89_13235 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC89_13240 ENOG4105BZ4 penicillin-binding protein FOC89_13245 ENOG4108XFG YwhD family FOC89_13250 ENOG4108Z4T Peptidase M50 FOC89_13255 ENOG41069HH 4-oxalocrotonate tautomerase FOC89_13260 ENOG4105DCI Phosphohydrolase FOC89_13265 ENOG4108MES Periplasmic binding protein FOC89_13270 ENOG4105E0A ABC, transporter FOC89_13275 ENOG4105EHG Permease protein FOC89_13280 ENOG4105DQ5 transport system permease protein FOC89_13290 ENOG4108VCI transcription factor, rsfa family FOC89_13305 ENOG4108IJ2 phosphate acetyltransferase FOC89_13320 ENOG4108VKI Cell wall hydrolase FOC89_13340 ENOG4107SVH Potassium channel protein FOC89_13350 ENOG410667J hydrolase FOC89_13355 ENOG4105VCH membrane FOC89_13365 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC89_13370 ENOG4105CJ1 ABC, transporter FOC89_13375 ENOG41090WU lipolytic protein G-D-S-L family FOC89_13390 ENOG4105D6E homoserine dehydrogenase FOC89_13415 ENOG4108Y4K DNA-binding transcriptional activator FOC89_13425 ENOG4105WH1 Two component transcriptional regulator luxr family FOC89_13430 ENOG4105BZU Histidine kinase FOC89_13435 ENOG4105DWF phosphomethylpyrimidine kinase FOC89_13440 ENOG4105BZU Histidine kinase FOC89_13445 ENOG4105VCD cytoplasmic protein FOC89_13450 ENOG4105D22 carbon starvation protein FOC89_13455 ENOG4105DY9 regulatoR FOC89_13460 ENOG41079KZ Major Facilitator Superfamily FOC89_13480 ENOG4105EN6 Membrane FOC89_13485 ENOG4106YBV Methyl-accepting chemotaxis FOC89_13495 ENOG4108S4H thioesterase Superfamily protein FOC89_13505 ENOG4105JEU Glycosyl transferase, family 2 FOC89_13510 ENOG4105C5H ABC transporter FOC89_13530 ENOG4105CKK Glycosyl transferase, family 2 FOC89_13535 ENOG41067SE Tetr family transcriptional regulator FOC89_13545 ENOG4105E0X reductase FOC89_13550 ENOG4106F5Q Membrane FOC89_13565 ENOG4105DY9 regulatoR FOC89_13570 ENOG4108HRK Histidine kinase FOC89_13575 ENOG4107RGD Major Facilitator superfamily FOC89_13590 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC89_13600 ENOG4105IW1 AmiS UreI transporter FOC89_13610 ENOG4105CMR udp-glucose 4-epimerase FOC89_13615 ENOG4108UT2 hemolysin iii FOC89_13625 ENOG4105C1J atp-dependent rna helicase FOC89_13640 ENOG4105DPN Oligoendopeptidase f FOC89_13660 ENOG4105C0H protease FOC89_13665 ENOG4105Q2H domain protein FOC89_13680 ENOG4105BZU Histidine kinase FOC89_13685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_13715 ENOG4105CDU Replicative dna helicase FOC89_13725 ENOG4105BZR domain protein FOC89_13730 ENOG4108XMW Membrane FOC89_13740 ENOG4108UUM single-stranded DNA-binding protein FOC89_13750 ENOG4105C3G gtp-binding protein FOC89_13755 ENOG4105VDK protein, conserved in bacteria FOC89_13760 ENOG4105D8X mechanosensitive ion channel FOC89_13765 ENOG4108ZDA Sporulation protein YyaC FOC89_13770 ENOG4105FA0 parb-like partition protein FOC89_13775 ENOG4107QJE Chromosome Partitioning Protein FOC89_13805 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC89_13825 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC89_13830 ENOG410848D S4 domain protein YaaA FOC89_13845 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC89_13880 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC89_13915 ENOG4105ZMH deoxynucleoside kinase FOC89_13925 ENOG4105GTG Isochorismatase FOC89_13930 ENOG4108Z6B deaminase FOC89_13940 ENOG4105C6E dna polymerase iii FOC89_13960 ENOG41067KS pro-sigma K processing FOC89_13995 ENOG4105CXN decarboxylase FOC89_14005 ENOG4105FA2 dna polymerase iii FOC89_14010 ENOG4105MA4 psp1 domain protein FOC89_14020 ENOG41060K3 Methyltransferase FOC89_14030 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC89_14035 ENOG4105KRN Transcriptional regulator, abrb family FOC89_14045 ENOG4105F8V Hydrolase, tatD family FOC89_14050 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC89_14060 ENOG4105XFA sporulation peptidase YabG FOC89_14065 ENOG4105W42 Veg protein FOC89_14080 ENOG4105DFT pur operon repressor FOC89_14085 ENOG4105KME endoribonuclease L-psp FOC89_14115 ENOG4108JA2 transcriptioN-repair coupling factor FOC89_14120 ENOG4108M14 stage v sporulation protein t FOC89_14130 ENOG4108IY2 MazG family FOC89_14135 ENOG41082I2 s4 domain protein FOC89_14140 ENOG4105VYY sporulation protein yabp FOC89_14155 ENOG41060GV RNA binding s1 domain protein FOC89_14180 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC89_14185 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC89_14200 ENOG4105C6T cysteine synthase FOC89_14205 ENOG4105CRQ synthase (Component I) FOC89_14210 ENOG4105DDQ anthranilate synthase FOC89_14215 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC89_14220 ENOG4105EEI dihydropteroate synthase FOC89_14225 ENOG4105KRF dihydroneopterin aldolase FOC89_14230 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC89_14240 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC89_14330 ENOG4108Z0C Uvrb UvrC protein FOC89_14345 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC89_14355 ENOG4105CTP PilT protein domain protein FOC89_14375 ENOG4105D7W serine acetyltransferase FOC89_14390 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC89_14395 ENOG4105M0M Tetracycline resistance protein FOC89_14400 ENOG4105QIV RNA polymerase FOC89_14415 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC89_14440 ENOG4107Y49 methyltransferase FOC89_14455 ENOG4105XPM ribosomal protein FOC89_14585 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC89_14595 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC89_14640 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC89_14670 ENOG4105D1F ATP-binding protein FOC89_14685 ENOG4108NMV polysaccharide deacetylase FOC89_14765 ENOG4105C8B TIGR00159 family FOC89_14770 ENOG4107U5W ybbr family FOC89_14785 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC89_14790 ENOG4108VQT Alpha beta hydrolase fold protein FOC89_14800 ENOG4105CMG Carbohydrate kinase FOC89_14810 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC89_14815 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC89_14855 ENOG4108PSK reductase FOC89_14860 ENOG4108UMI ABC transporter, permease FOC89_14865 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC89_14870 ENOG4105D01 (LipO)protein FOC89_14885 ENOG4105IQ5 FAD linked oxidase domain protein FOC89_14900 ENOG4105C2C drug resistance transporter, Bcr CflA FOC89_14915 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC89_14920 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC89_14925 ENOG4105C3U ABC transporter FOC89_14930 ENOG4108JQ7 (ABC) transporter FOC89_14955 ENOG4105U5Y Transcriptional regulator FOC89_14965 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC89_14970 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC89_14980 ENOG4105II7 pyrroline-5-carboxylate reductase FOC89_14985 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC89_14995 ENOG4105E0C molybdate abc transporter FOC89_15000 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC89_15005 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC89_15035 ENOG4105F6E Acyl-transferase FOC89_15055 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC89_15065 ENOG4108RE7 deoxyribonuclease FOC89_15070 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC89_15095 ENOG4105C5H ABC transporter FOC89_15100 ENOG4105BZU Histidine kinase FOC89_15105 ENOG4105WH1 Two component transcriptional regulator luxr family FOC89_15110 ENOG4105CJ1 ABC, transporter FOC89_15115 ENOG41090VJ ABC-2 type transporter FOC89_15120 ENOG4108KYE ABC-2 type transporter FOC89_15130 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC89_15140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC89_15145 ENOG4105C3U ABC transporter FOC89_15150 ENOG4108JQ7 (ABC) transporter FOC89_15155 ENOG410667J hydrolase FOC89_15180 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC89_15185 ENOG4105ERH Fumarylacetoacetate hydrolase FOC89_15200 ENOG4105CPF Cell wall formation (By similarity) FOC89_15205 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC89_15220 ENOG4107ZXI Rhomboid family FOC89_15230 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC89_15235 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC89_15245 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC89_15345 ENOG4105K8N protein family UPF0079, ATPase FOC89_15350 ENOG41072GX Peptidase M22 Glycoprotease FOC89_15355 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC89_15365 ENOG4105C5H ABC transporter FOC89_15380 ENOG4108TYN CAAX amino terminal protease family protein FOC89_15400 ENOG4105C7N Xanthine uracil vitamin C permease FOC89_15410 ENOG4105BZU Histidine kinase FOC89_15435 ENOG4107ZXU DSBA oxidoreductase FOC89_15465 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC89_15485 ENOG4108SHN Glycosyl transferase, family 2 FOC89_15530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC89_15550 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC89_15555 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC89_15560 ENOG4105C83 adenylosuccinate lyase FOC89_15570 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC89_15595 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC89_15605 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC89_15630 ENOG4105C4R Atp-dependent dna helicase FOC89_15660 ENOG4108W2Y isochorismatase FOC89_15665 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC89_15670 ENOG4108UMI ABC transporter, permease FOC89_15675 ENOG4105D01 (LipO)protein FOC89_15695 ENOG410834F Transcriptional regulator FOC89_15700 ENOG4107I77 yiaA/B two helix domain FOC89_15720 ENOG4105CBD Diacylglycerol kinase FOC89_15725 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC89_15730 ENOG4108JPW Aminotransferase FOC89_15740 ENOG4105C26 Dehydrogenase FOC89_15745 ENOG4105KPY Small multidrug resistance protein FOC89_15765 ENOG4105D9N nucleoside FOC89_15770 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC89_15785 ENOG4108W15 Protein of unknown function (DUF1456) FOC89_15800 ENOG4105DTQ mandelate racemase muconate lactonizing FOC89_15810 ENOG4105DFD Na H antiporter FOC89_15830 ENOG4105D3R alkyl hydroperoxide reductase FOC89_15850 ENOG4105EHG Permease protein FOC89_15855 ENOG4105DQ5 transport system permease protein FOC89_15860 ENOG4108V5C ABC transporter FOC89_15880 ENOG4106UIA FOC89_15885 ENOG4106UIA FOC89_15900 ENOG4105BZU Histidine kinase FOC89_15920 ENOG410756H nucleotidyltransferase FOC89_15940 ENOG4105E5Q amino acid AbC transporter FOC89_15945 ENOG4105EAB amino acid AbC transporter FOC89_15955 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC89_15980 ENOG4105C5B carbamate kinase FOC89_16000 ENOG4105CI1 PTS System FOC89_16030 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC89_16045 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC89_16060 ENOG4105C5H ABC transporter FOC89_16090 ENOG41062JF Transcriptional regulator FOC89_16110 ENOG4105DEU major facilitator superfamily FOC89_16140 ENOG4108N0M stress protein FOC89_16145 ENOG4106FN3 tellurium resistance protein FOC89_16150 ENOG4106FN3 tellurium resistance protein FOC89_16155 ENOG4107TS3 membrane protein, TerC FOC89_16160 ENOG4108TTB tellurium resistance protein FOC89_16180 ENOG4105KJF protein tyrosine phosphatase FOC89_16190 ENOG4107U9T Pfam:Ribonuclease_BN FOC89_16195 ENOG4105C59 p-type ATPase FOC89_16200 ENOG4108IPJ Membrane FOC89_16215 ENOG4105C3F Signal peptidase i FOC89_16225 ENOG4107ZTW SNARE associated Golgi FOC89_16240 ENOG410606W general stress protein FOC89_16245 ENOG4105UPD Calcium Proton FOC89_16280 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC89_16330 ENOG4108A04 Beta-lactamase FOC89_16345 ENOG4105CKK Glycosyl transferase, family 2 FOC89_16350 ENOG4107QQG Dehydrogenase FOC89_16355 ENOG4105C3I Nad-dependent epimerase dehydratase FOC89_16375 ENOG4105F1A Pyruvate formate-lyase FOC89_16395 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC89_16400 ENOG4105ECP epimerase FOC89_16430 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC89_16435 ENOG4105CEN a g-specific adenine glycosylase FOC89_16440 ENOG4106BXE FOC89_16460 ENOG4105BZ1 (ABC) transporter FOC89_16465 ENOG4107NBY Membrane FOC89_16470 ENOG4105CBC glutamate synthase FOC89_16480 ENOG4108IUW ABC transporter FOC89_16500 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC89_16505 ENOG4105G5W regulator Fur family FOC89_16620 ENOG4108JQC penicillin-binding protein 1A FOC89_16625 ENOG4107ZQN disulfide bond FOC89_16635 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC89_16645 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC89_16650 ENOG4105BZU Histidine kinase FOC89_16655 ENOG4105CYN Serine protein kinase FOC89_16675 ENOG4105C94 Transporter FOC89_16690 ENOG4105DZ6 Band 7 protein FOC89_16700 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC89_16705 ENOG4108V9W transcriptional regulatory protein FOC89_16710 ENOG4105D4T Citrate transporter FOC89_16730 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC89_16735 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC89_16740 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC89_16745 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC89_16750 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC89_16755 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC89_16760 ENOG4108STX response regulator FOC89_16765 ENOG4105US7 Histidine kinase FOC89_16790 ENOG4108MRH transcriptional regulatory protein FOC89_16800 ENOG4105C6K Malic enzyme FOC89_16810 ENOG4108UZ3 Transporter FOC89_16815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC89_16825 ENOG4105BZU Histidine kinase FOC89_16830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_16835 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC89_16840 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC89_16845 ENOG4108JB9 formate dehydrogenase FOC89_16865 ENOG4105CUB amino acid FOC89_16875 ENOG4105C59 p-type ATPase FOC89_16880 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC89_16915 ENOG41073R8 VanW family FOC89_16920 ENOG4108KGH TRANSCRIPTIONal FOC89_16925 ENOG4105D9N nucleoside FOC89_16930 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC89_16935 ENOG4105C37 (CBS) domain FOC89_16940 ENOG4108IJ0 Aspartate ammonia-lyase FOC89_16945 ENOG4105DAA L-lactate FOC89_16960 ENOG4105DUX Transporter FOC89_16965 ENOG4108MES Periplasmic binding protein FOC89_16970 ENOG4105DQ5 transport system permease protein FOC89_16975 ENOG4108IHU transport system permease protein FOC89_16980 ENOG4105E0A ABC, transporter FOC89_16995 ENOG4105EXW epimerase dehydratase FOC89_17000 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOC89_17010 ENOG4107T89 von Willebrand factor, type A FOC89_17015 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC89_17020 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC89_17035 ENOG4105BZU Histidine kinase FOC89_17040 ENOG4105D5Q Arginine ornithine antiporter FOC89_17045 ENOG4107414 GntR family transcriptional regulator FOC89_17050 ENOG4105C5Y PTS System FOC89_17055 ENOG4105CG3 alpha amylase, catalytic region FOC89_17070 ENOG4105E1K spore germination protein FOC89_17080 ENOG4105CRN Aminoglycoside phosphotransferase FOC89_17085 ENOG4105BZG amino acid carrier protein FOC89_17090 ENOG4105CDA abc transporter atp-binding protein FOC89_17095 ENOG4105CT1 (ABC) transporter FOC89_17100 ENOG4105EAD ABC transporter FOC89_17105 ENOG4105DRP amino acid AbC transporter FOC89_17110 ENOG4108IQI permease FOC89_17135 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC89_17140 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC89_17145 ENOG4105BZU Histidine kinase FOC89_17150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_17160 ENOG4105CHH sulfate transporter FOC89_17165 ENOG41068KF Universal stress protein FOC89_17175 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC89_17185 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC89_17190 ENOG4108JQ7 (ABC) transporter FOC89_17200 ENOG4105CXY transporter FOC89_17205 ENOG41067TZ transcriptional regulator, MarR family FOC89_17210 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC89_17215 ENOG4105ETE Transcriptional regulator (LacI family FOC89_17220 ENOG4108RVA ribokinase FOC89_17235 ENOG4105CNN ABC, transporter FOC89_17240 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC89_17305 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC89_17310 ENOG41069ER domain protein FOC89_17315 ENOG4105VZ8 Transcriptional regulator FOC89_17320 ENOG4107D63 FOC89_17330 ENOG4105DUX Transporter FOC89_17350 ENOG4105C85 amino acid FOC89_17355 ENOG4105C7N Xanthine uracil vitamin C permease FOC89_17370 ENOG4105MA6 gCN5-related N-acetyltransferase FOC89_17395 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC89_17400 ENOG4105E2S oxidase) subunit II FOC89_17405 ENOG4108IQI permease FOC89_17420 ENOG4106CAD Protein of unknown function (DUF3311) FOC89_17425 ENOG4105E1V na solute symporter FOC89_17440 ENOG4108NHD germination protein FOC89_17445 ENOG4105CE1 Ferrous iron transport protein b FOC89_17450 ENOG4105CE1 Ferrous iron transport protein b FOC89_17455 ENOG4105CE1 Ferrous iron transport protein b FOC89_17460 ENOG4105CVA phosphate FOC89_17465 ENOG4105C8U phosphate abc transporter FOC89_17470 ENOG4105E2Z phosphate ABC transporter (Permease FOC89_17600 ENOG41080XQ Signal transduction protein with cbs domains FOC89_17620 ENOG4105ETU transcriptional activator (TenA FOC89_17630 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC89_17640 ENOG4108VEU Thiamine monophosphate synthase FOC89_17645 ENOG41080HI glycine oxidase FOC89_17660 ENOG4105D06 uba thif-type nad fad binding protein FOC89_17665 ENOG4105DWF phosphomethylpyrimidine kinase FOC89_17715 ENOG4108INS Transcriptional regulator FOC89_17730 ENOG4105C7N Xanthine uracil vitamin C permease FOC89_17740 ENOG4108PXI ErfK YbiS YcfS YnhG FOC89_17775 ENOG4108B31 Spore germination protein FOC89_17795 ENOG4107Y03 Nitroreductase FOC89_17800 ENOG4105ED1 spovr family FOC89_17810 ENOG4108TCS Glutamyl endopeptidase FOC89_17820 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC89_17825 ENOG4105XTG Pfam:DUF156 FOC89_17830 ENOG4105VFE sira family FOC89_17835 ENOG4107TPS domain protein FOC89_17840 ENOG4105VFE sira family FOC89_17845 ENOG41085GJ domain protein FOC89_17855 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC89_17860 ENOG41087NI Sulfite exporter TauE/SafE FOC89_17870 ENOG4108KGH TRANSCRIPTIONal FOC89_17875 ENOG4105CZN Potassium uptake protein FOC89_17895 ENOG4105EMD TRANSCRIPTIONal FOC89_17900 ENOG4105VCP PTS System FOC89_17905 ENOG4105VZJ PTS System FOC89_17925 ENOG41069ER domain protein FOC89_17930 ENOG4107RBB ABC transporter, permease FOC89_17935 ENOG4105C19 ABC transporter FOC89_17965 ENOG4105WEF catalase FOC89_18000 ENOG4107T5V SNARE associated Golgi FOC89_18035 ENOG4105CUB amino acid FOC89_18040 ENOG4107RWR Sodium hydrogen exchanger FOC89_18050 ENOG4106KNT transcriptional regulator FOC89_18090 ENOG4108YXU transcriptional regulator AsnC family FOC89_18105 ENOG4105KPY Small multidrug resistance protein FOC89_18130 ENOG4105NF4 modulator of drug activity FOC89_18140 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC89_18145 ENOG4105E5W Transporter FOC89_18155 ENOG4107RKG DJ-1/PfpI family FOC89_18160 ENOG4105CH6 catalase FOC89_18170 ENOG4105D5Q Arginine ornithine antiporter FOC89_18175 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC89_18185 ENOG4105C26 Dehydrogenase FOC89_18190 ENOG4105BZ1 (ABC) transporter FOC89_18195 ENOG4105BZ1 (ABC) transporter FOC89_18205 ENOG4105DRP amino acid AbC transporter FOC89_18210 ENOG4105CDA abc transporter atp-binding protein FOC89_18225 ENOG410839P FOC89_18260 ENOG4107FQX Alpha-acetolactate decarboxylase FOC89_18280 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC89_18285 ENOG4105D4P Coproporphyrinogen iii oxidase FOC89_18300 ENOG4105CHH sulfate transporter FOC89_18345 ENOG4106AKK s-layer domain-containing protein FOC89_18355 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC89_18360 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC89_18375 ENOG4105CGU Enoyl-CoA hydratase FOC89_18395 ENOG4105DER m42 family FOC89_18415 ENOG4105CTU Proline racemase FOC89_18460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC89_18470 ENOG4108JQ7 (ABC) transporter FOC89_18485 ENOG4105CSH Transporter FOC89_18495 ENOG4108MRH transcriptional regulatory protein FOC89_18530 ENOG4105EYH Exonuclease FOC89_18540 ENOG4107QI6 Cysteine desulfurase FOC89_18590 ENOG4105CDU Replicative dna helicase FOC89_18615 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC89_18690 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC89_18720 ENOG4105CMT Dihydroxyacetone kinase FOC89_18730 ENOG4105CMT Dihydroxyacetone kinase FOC89_18745 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC89_18810 ENOG4105WN5 stage II sporulation protein FOC89_18820 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC89_18830 ENOG4108MJI response regulator FOC89_18835 ENOG4105BZU Histidine kinase FOC89_18840 ENOG4105BZU Histidine kinase FOC89_18900 ENOG4107VRP DNA repair exonuclease FOC89_18905 ENOG4106D4I domain protein FOC89_18960 ENOG4108MUZ hydrolase FOC89_18980 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC89_18995 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC89_19010 ENOG4105EMN RNA polymerase sigma factor FOC89_19020 ENOG4105CNI cell division protein FtsW FOC89_19035 ENOG4105C57 major facilitator superfamily FOC89_19040 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC89_19050 ENOG4105EEM helicase FOC89_19055 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC89_19080 ENOG4105K59 histidine triad (HIT) protein FOC89_19155 ENOG410905X membrane-flanked domain protein FOC89_19160 ENOG4105CKV Membrane FOC89_19200 ENOG410905X membrane-flanked domain protein FOC89_19205 ENOG4105CKV Membrane FOC89_19210 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC89_19215 ENOG4105BZ4 penicillin-binding protein FOC89_19230 ENOG4105C1Q protoporphyrinogen oxidase FOC89_19260 ENOG4105ECB domain protein FOC89_19280 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FOC89_19290 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC89_19300 ENOG4106AXD FOC89_19305 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC89_19310 ENOG4105DF9 Lipoate-protein, ligase FOC89_19320 ENOG4105CEY Amp-dependent synthetase and ligase FOC89_19370 ENOG4107RN3 metallophosphoesterase FOC89_19380 ENOG4107TVP HD domain protein FOC89_19390 ENOG4108AEY RNA polymerase sigma factor FOC89_19395 ENOG41086D8 Transcriptional regulator FOC89_19415 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC89_19440 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC89_19445 ENOG4105C8Q Methyl-accepting chemotaxis FOC89_19470 ENOG4107QP3 malate synthase g FOC89_19500 ENOG4105XVF Competence transcription factor FOC89_19565 ENOG4105ERH Fumarylacetoacetate hydrolase FOC89_19590 ENOG4105CAQ asparagine synthetase FOC89_19595 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC89_19600 ENOG4105CH6 catalase FOC89_19605 ENOG4105BZU Histidine kinase FOC89_19625 ENOG4105QNR S1 RNA binding domain protein FOC89_19635 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC89_19645 ENOG4107AYK membrAne FOC89_19650 ENOG41073B9 FOC89_19660 ENOG4108KP7 hydrolase FOC89_19670 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC89_19695 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC89_19700 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC89_19715 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC89_19730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC89_19735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC89_19745 ENOG4108JQ7 (ABC) transporter FOC89_19750 ENOG4105UQX Mate efflux family protein FOC89_19770 ENOG4108ZCF integral membrane protein FOC89_19780 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC89_19790 ENOG4105DPN Oligoendopeptidase f FOC89_19805 ENOG4108Z18 K06886 hemoglobin FOC89_19810 ENOG4105MIX Adenylate cyclase FOC89_19825 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC89_19830 ENOG4105EMS pseudouridine synthase FOC89_19850 ENOG4105K64 Glycosyl transferase, family 2 FOC89_19870 ENOG4107TVC Glycosyl transferase, family 2 FOC89_19890 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC89_19895 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC89_19905 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC89_19980 ENOG4105CK7 Sodium proline symporter FOC89_19990 ENOG4105DDQ anthranilate synthase FOC89_20085 ENOG4105C7S Dehydrogenase FOC89_20095 ENOG4105VZ8 Transcriptional regulator FOC89_20150 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC89_20160 ENOG4105DZ1 carboxypeptidase FOC89_20165 ENOG4105VFR signal peptidase FOC89_20200 ENOG4105C26 Dehydrogenase FOC89_20210 ENOG4105F38 ABC transporter, permease FOC89_20215 ENOG4105D38 putrescine abc transporter FOC89_20220 ENOG4107RUE extracellular solute-binding protein family 1 FOC89_20230 ENOG4105EYF MMPL domain protein FOC89_20240 ENOG4108YBP pseudouridine synthase FOC89_20250 ENOG4105K4I Scp-like extracellular FOC89_20255 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC89_20260 ENOG4105CQB FAD linked oxidase domain protein FOC89_20275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_20280 ENOG4105BZU Histidine kinase FOC89_20285 ENOG4105JXH GntR family transcriptional regulator FOC89_20305 ENOG4106A3R peptidase FOC89_20315 ENOG4108QTI )-transporter FOC89_20320 ENOG4107TS3 membrane protein, TerC FOC89_20325 ENOG4105CZN Potassium uptake protein FOC89_20330 ENOG410681C small acid-soluble spore protein FOC89_20335 ENOG4108Z7G MaoC domain protein dehydratase FOC89_20355 ENOG4105CHR reductase FOC89_20365 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC89_20385 ENOG4105C4Y ABC transporter FOC89_20390 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC89_20395 ENOG4107RCV ABC transporter, permease FOC89_20415 ENOG4105E98 transcriptional regulator DeoR family FOC89_20425 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC89_20435 ENOG4105PXI polysaccharide deacetylase FOC89_20445 ENOG4105BZU Histidine kinase FOC89_20450 ENOG41090MY MarR family Transcriptional regulator FOC89_20460 ENOG4106DF1 FOC89_20465 ENOG4105BZU Histidine kinase FOC89_20475 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC89_20480 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC89_20520 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC89_20540 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC89_20545 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC89_20550 ENOG4105CZV ABC transporter FOC89_20560 ENOG4105CJ1 ABC, transporter FOC89_20600 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC89_20605 ENOG4105EA8 2-Nitropropane dioxygenase FOC89_20610 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC89_20620 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC89_20645 ENOG4105NQC Flavodoxin FOC89_20680 ENOG4107QMU Mate efflux family protein FOC89_20685 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC89_20715 ENOG4105CZN Potassium uptake protein FOC89_20720 ENOG41063Y9 FOC89_20725 ENOG4105KBJ sporulation protein ytfj FOC89_20745 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC89_20750 ENOG4105C7K acetolactate synthase FOC89_20755 ENOG4108ZP8 Acetolactate synthase small subunit FOC89_20760 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC89_20770 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC89_20830 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC89_20845 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC89_20850 ENOG4105E0M Sulfatase FOC89_20860 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC89_20880 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC89_20885 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC89_20895 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC89_20900 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC89_20905 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC89_20910 ENOG4105C8J )-transporter FOC89_20930 ENOG4105DFD Na H antiporter FOC89_20950 ENOG4105ENE Histidine kinase FOC89_20955 ENOG4105WH1 Two component transcriptional regulator luxr family FOC89_20975 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC89_21020 ENOG4105CJ3 phosphate transporter FOC89_21025 ENOG4107GRR phosphate transport regulator FOC89_21030 ENOG4105BZ4 penicillin-binding protein FOC89_21045 ENOG4105BZU Histidine kinase FOC89_21050 ENOG4105I3N Conserved Protein FOC89_21065 ENOG4105BZU Histidine kinase FOC89_21100 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC89_21105 ENOG4105DZ1 carboxypeptidase FOC89_21110 ENOG4108JIC nucleoside recognition domain protein FOC89_21120 ENOG4105FE9 pseudouridine synthase FOC89_21130 ENOG4107TWT Cytochrome c biogenesis protein FOC89_21135 ENOG4105CRE cytochrome C FOC89_21140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_21145 ENOG4105BZU Histidine kinase FOC89_21150 ENOG4108WBT adenosyltransferase FOC89_21155 ENOG41063SB peptidase FOC89_21165 ENOG4108SAX Membrane FOC89_21180 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC89_21185 ENOG4105I7S Abortive infection protein FOC89_21195 ENOG4107RGJ metallophosphoesterase FOC89_21200 ENOG4107X2D transcriptional regulator, merr family FOC89_21205 ENOG4108S6Z Negative regulator of genetic competence FOC89_21230 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC89_21235 ENOG4105HDK L-asparaginase FOC89_21270 ENOG4105S2F FOC89_21275 ENOG41065D1 FOC89_21305 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC89_21320 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC89_21330 ENOG4105EAH synthase FOC89_21350 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC89_21355 ENOG41068YB TPR repeat-containing protein FOC89_21370 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC89_21375 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC89_21380 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC89_21410 ENOG4108JYZ YitT family FOC89_21415 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC89_21430 ENOG4105FJR Lmbe family FOC89_21435 ENOG4105CPK Glycosyl transferase (Group 1 FOC89_21470 ENOG4105DVT helicase FOC89_21475 ENOG4105YAC FOC89_21495 ENOG4105CSM endonuclease III FOC89_21505 ENOG4105BZ4 penicillin-binding protein FOC89_21565 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC89_21575 ENOG4105DVT helicase FOC89_21580 ENOG4105CTD carboxy-peptidase FOC89_21595 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC89_21605 ENOG4105C2W permease FOC89_21610 ENOG4105DHF Membrane FOC89_21615 ENOG410890F Dynamin family FOC89_21625 ENOG4108W0I acetyltransferase FOC89_21635 ENOG4105KHC sulfurtransferase FOC89_21660 ENOG4106032 Glutathionylspermidine synthase FOC89_21720 ENOG4105CPK Glycosyl transferase (Group 1 FOC89_21735 ENOG4108SZE gCN5-related N-acetyltransferase FOC89_21755 ENOG41081VK Ribonuclease FOC89_21820 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC89_21830 ENOG4107RWR Sodium hydrogen exchanger FOC89_21835 ENOG4105CN5 Metallo-Beta-Lactamase FOC89_21840 ENOG4108Z5V transcriptional regulator, merr family FOC89_21850 ENOG4105H67 Protein of unknown function (DUF421) FOC89_21855 ENOG41080C8 DUF218 domain FOC89_21910 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC89_21920 ENOG4107R0U MotA TolQ exbB proton channel FOC89_21925 ENOG4105ER2 Ompa motb domain protein FOC89_21930 ENOG4107YTP response regulator receiver protein FOC89_21935 ENOG4105CBS Chea signal transduction histidine kinase FOC89_21940 ENOG4105DD5 Flagellar motor switch protein FOC89_21955 ENOG4105BZU Histidine kinase FOC89_21975 ENOG4105E1Q flagellar hook-associated protein FOC89_21980 ENOG4105DTJ flagellar hook-associated protein FOC89_21985 ENOG4107TPX flagellar hook-associated FOC89_22000 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC89_22005 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC89_22015 ENOG4107U2N Flagellar M-ring protein FOC89_22020 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC89_22050 ENOG4105BZE flagellar hook protein, FlgE FOC89_22065 ENOG4107R88 Chemotaxis protein (CheV) FOC89_22075 ENOG4105I03 Flagellin FOC89_22080 ENOG4105I03 Flagellin FOC89_22085 ENOG4105E4C Lytic transglycosylase catalytic FOC89_22095 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC89_22100 ENOG4105DD5 Flagellar motor switch protein FOC89_22110 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC89_22115 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC89_22125 ENOG4105D00 flagellar biosynthetic protein flhB FOC89_22130 ENOG4105D7B Flagellar biosynthesis protein flha FOC89_22135 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC89_22140 ENOG4105KTQ flagellar basal-body rod protein FOC89_22145 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC89_22180 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC89_22210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC89_22215 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC89_22220 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC89_22225 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC89_22285 ENOG4105K56 Transcriptional regulator FOC89_22295 ENOG4105CAQ asparagine synthetase FOC89_22315 ENOG4105PGM cation diffusion facilitator family transporter FOC89_22325 ENOG4105DRR Transcriptional regulator, GntR family FOC89_22330 ENOG4108UZ3 Transporter FOC89_22335 ENOG4105CKI cobalamin synthesis protein FOC89_22340 ENOG4108PJD permease FOC89_22355 ENOG4105DFD Na H antiporter FOC89_22360 ENOG4105VUF Transcriptional regulator FOC89_22370 ENOG4105C9Q fumarate hydratase class II FOC89_22390 ENOG4107QJQ Mate efflux family protein FOC89_22395 ENOG4105EC3 peptidase S51, dipeptidase E FOC89_22415 ENOG4107QIV Cytochrome c biogenesis protein FOC89_22445 ENOG4106BRA Membrane FOC89_22480 ENOG4105CJ1 ABC, transporter FOC89_22500 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC89_22510 ENOG4108IJ0 Aspartate ammonia-lyase FOC89_22515 ENOG4105C6K Malic enzyme FOC89_22580 ENOG4105FVX FOC89_22620 ENOG4105CSR polyphosphate kinase 2 FOC89_22625 ENOG4105DXI Major Facilitator superfamily FOC89_22640 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC89_22650 ENOG4105EU0 Major facilitator Superfamily FOC89_22655 ENOG4105C6T cysteine synthase FOC89_22675 ENOG4105C8J )-transporter FOC89_22685 ENOG4105X5K response regulator receiver protein FOC89_22690 ENOG4105H67 Protein of unknown function (DUF421) FOC89_22705 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC89_22710 ENOG4105CHR reductase FOC89_22715 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC89_22720 ENOG4105C7K acetolactate synthase FOC89_22725 ENOG4108ZP8 Acetolactate synthase small subunit FOC89_22730 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC89_22740 ENOG4105C7B Threonine dehydratase FOC89_22765 ENOG4105C6X Major Facilitator FOC89_22770 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC89_22780 ENOG4105DY9 regulatoR FOC89_22785 ENOG4105CYC Transferase FOC89_22805 ENOG4105F6J Alpha beta hydrolase fold FOC89_22810 ENOG4105VTR Integrase FOC89_22925 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FOC89_22965 ENOG410900G Protein of unknown function (DUF421) FOC89_22975 ENOG4105CNU cell division protein FtsK FOC89_23020 ENOG4105CAR Terminase, large subunit FOC89_23030 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC89_23095 ENOG4105XSJ toxin secretion phage lysis holin FOC89_23165 ENOG41068WN FOC89_23185 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC89_23200 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC89_23205 ENOG4105C0X amino acid FOC89_23230 ENOG4107RHR regulatoR FOC89_23240 ENOG4105D9N nucleoside FOC89_23245 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC89_23280 ENOG4107RAQ aminopeptidase FOC89_23285 ENOG4107R16 Multicopper oxidase FOC89_23335 ENOG4108T5E Copper resistance protein FOC89_23340 ENOG4105KTB nuclear export factor GLE1 FOC89_23345 ENOG4107RT3 EamA-like transporter family FOC89_23350 ENOG4105GZI Transcriptional regulator FOC89_23355 ENOG4108Z40 Transcriptional regulator FOC89_23360 ENOG4107ZXU DSBA oxidoreductase FOC89_23365 ENOG4108TVJ Nitroreductase FOC89_23370 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC89_23375 ENOG4106F5Q Membrane FOC89_23390 ENOG4105CKI cobalamin synthesis protein FOC89_23410 ENOG4108Z7G MaoC domain protein dehydratase FOC89_23415 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC89_23425 ENOG4105C0Z ABC transporter FOC89_23430 ENOG4108IV0 ABC, transporter FOC89_23435 ENOG4105C32 Amino acid ABC transporter (Permease) FOC89_23445 ENOG4105SKE transcriptional Regulator LysR family FOC89_23475 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC89_23480 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC89_23485 ENOG4108JJ9 ABC, transporter FOC89_23490 ENOG4108JJ8 (ABC) transporter FOC89_23505 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC89_23535 ENOG4105BZ1 (ABC) transporter FOC89_23540 ENOG4105EFI regulatoR FOC89_23545 ENOG4105BZU Histidine kinase FOC89_23565 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC89_23575 ENOG4106AKJ FOC89_23590 ENOG4105D6E homoserine dehydrogenase FOC89_23615 ENOG4108KGH TRANSCRIPTIONal FOC89_23625 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC89_23630 ENOG4105BZU Histidine kinase FOC89_23645 ENOG4105KT7 mgtC SapB transporter FOC89_23650 ENOG4105VRR gCN5-related N-acetyltransferase FOC89_23660 ENOG4105DUU IucA IucC family protein FOC89_23665 ENOG4105CEY Amp-dependent synthetase and ligase FOC89_23680 ENOG4108WBH protein TIM barrel FOC89_23685 ENOG4105YWU small acid-soluble spore protein FOC89_23695 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC89_23745 ENOG4105KRN Transcriptional regulator, abrb family FOC89_23765 ENOG4105YVS arsR family transcriptional regulator FOC89_23770 ENOG4107SET aldo keto reductase FOC89_23775 ENOG4107XZQ multidrug resistance protein FOC89_23800 ENOG4105C8Q Methyl-accepting chemotaxis FOC89_23815 ENOG4108K88 Membrane FOC89_23820 ENOG4108WPJ Ferritin-like domain FOC89_23835 ENOG4105DEN Luciferase family FOC89_23855 ENOG4107QM2 Aldo Keto reductase FOC89_23860 ENOG4105CKI cobalamin synthesis protein FOC89_23925 ENOG4105DSE periplasmic solute binding protein FOC89_23935 ENOG4105K4T epimerase FOC89_23945 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC89_23970 ENOG4107TB6 phosphoglycerate mutase FOC89_23990 ENOG4107T5V SNARE associated Golgi FOC89_24005 ENOG4108PJD permease FOC89_24015 ENOG4108S4H thioesterase Superfamily protein FOC89_24025 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC89_24045 ENOG4105SXS Protein of unknown function (DUF456) FOC89_24050 ENOG4105C37 (CBS) domain FOC89_24070 ENOG4108Z7R Chaperone CsaA FOC89_24090 ENOG4108ZRV stage ii sporulation protein p FOC89_24100 ENOG4108VXD carboxy-peptidase FOC89_24110 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC89_24135 ENOG4108X4Q Hydrolase FOC89_24145 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC89_24165 ENOG41087PP glycosyltransferase MGT family FOC89_24170 ENOG4108JYZ YitT family FOC89_24175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC89_24205 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC89_24275 ENOG4105KBJ sporulation protein ytfj FOC89_24300 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC89_24325 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC89_24335 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC89_24340 ENOG4105EMN RNA polymerase sigma factor FOC89_24355 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOC89_24375 ENOG4108V06 Glutathione peroxidase FOC89_24390 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC89_24400 ENOG4108IUE nitrate reductase beta subunit FOC89_24405 ENOG4105R3A Nitrate reductase FOC89_24420 ENOG4108Z40 Transcriptional regulator FOC89_24425 ENOG4105K63 Thioredoxin FOC89_24430 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC89_24435 ENOG4106HZJ FOC89_24440 ENOG4108X3M OsmC Ohr family protein FOC89_24445 ENOG4105D3W isochorismatase FOC89_24455 ENOG4107V6Q Cyclic nucleotide-binding domain FOC89_24460 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC89_24465 ENOG4105D06 uba thif-type nad fad binding protein FOC89_24470 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC89_24475 ENOG4108ZAF Molybdopterin FOC89_24495 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC89_24500 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC89_24505 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC89_24510 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC89_24515 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC89_24520 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC89_24555 ENOG4105MCT stage V sporulation protein S FOC89_24585 ENOG4105C5H ABC transporter FOC89_24600 ENOG4108UUM single-stranded DNA-binding protein FOC89_24620 ENOG4107YX5 Pfam:DUF548 FOC89_24625 ENOG4105C75 arginyL-tRNA synthetase FOC89_24665 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC89_24670 ENOG4105C5S asparaginyl-tRNA synthetase FOC89_24690 ENOG4105EC2 ftsk spoIIIe FOC89_24775 ENOG4105BZW Glycerate kinase FOC89_24780 ENOG4107QPK )-transporter FOC89_24785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_24790 ENOG41062D9 Histidine kinase FOC89_24805 ENOG4105C8J )-transporter FOC89_24825 ENOG4107XGZ Hydrolase FOC89_24830 ENOG4105CY2 Citrate transporter FOC89_24835 ENOG4105C0A alcohol dehydrogenase FOC89_24850 ENOG4105KD7 acetyltransferase FOC89_24855 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC89_24880 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC89_24900 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC89_24915 ENOG4107RVG penicillin-binding protein FOC89_24925 ENOG4105E9Q Acyl-transferase FOC89_24930 ENOG4108UT2 hemolysin iii FOC89_24940 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC89_24950 ENOG4108RCR degv family FOC89_24955 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC89_24960 ENOG4108KF3 Electron transport protein SCO1 SenC FOC89_24965 ENOG4107Y70 Heat shock protein FOC89_24970 ENOG4105CAQ asparagine synthetase FOC89_24985 ENOG4108MES Periplasmic binding protein FOC89_24990 ENOG4105F0I Aminotransferase FOC89_25020 ENOG4107Y70 Heat shock protein FOC89_25025 ENOG4105D8X mechanosensitive ion channel FOC89_25030 ENOG4105BZU Histidine kinase FOC89_25035 ENOG4105WH1 Two component transcriptional regulator luxr family FOC89_25070 ENOG4105CMG Carbohydrate kinase FOC89_25075 ENOG4105CMG Carbohydrate kinase FOC89_25105 ENOG4108IJ8 ABC transporter FOC89_25110 ENOG4105E90 ABC transporter FOC89_25145 ENOG4105C37 (CBS) domain FOC89_25170 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC89_25185 ENOG4107S4Y M20 DapE family protein YgeY FOC89_25190 ENOG4108TSC N-acetyltransferase FOC89_25195 ENOG4108JUB Transcriptional regulator FOC89_25200 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC89_25240 ENOG4108N23 SpoOM-related protein FOC89_25245 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC89_25255 ENOG4105SZ6 Thioredoxin FOC89_25270 ENOG4107EV6 Inherit from COG: YD repeat protein FOC89_25350 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC89_25390 ENOG4105BZ4 penicillin-binding protein FOC89_25395 ENOG4105CZM Major Facilitator FOC89_25400 ENOG4105W8X HesB YadR YfhF-family protein FOC89_25410 ENOG4105DXD 2-methylcitrate dehydratase FOC89_25415 ENOG4105CR4 methylisocitrate lyase FOC89_25420 ENOG4105C1G acyl-Coa dehydrogenase FOC89_25425 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC89_25435 ENOG4105N14 lysine exporter protein LysE YggA FOC89_25440 ENOG4105E39 Enoyl-CoA hydratase FOC89_25455 ENOG4107RFY SbcCD D subunit FOC89_25460 ENOG4105EYH Exonuclease FOC89_25475 ENOG4105FCD Major Facilitator FOC89_25480 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC89_25485 ENOG4105E4F Isochorismate synthase FOC89_25490 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC89_25495 ENOG4105WQI isochorismatase FOC89_25500 ENOG4105CEY Amp-dependent synthetase and ligase FOC89_25505 ENOG4105WQT MbtH domain protein FOC89_25510 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC89_25525 ENOG4105K70 DNA-binding protein FOC89_25545 ENOG4105BZG amino acid carrier protein FOC89_25565 ENOG4105FE9 pseudouridine synthase FOC89_25570 ENOG4105C22 threonyL-tRNA synthetase FOC89_25575 ENOG4105C19 ABC transporter FOC89_25585 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC89_25605 ENOG4108D32 Methyltransferase FOC89_25625 ENOG41081I9 integral membrane protein FOC89_25640 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC89_25650 ENOG4105EYF MMPL domain protein FOC89_25675 ENOG4105WCN acetyltransferase FOC89_25705 ENOG4105C1Q protoporphyrinogen oxidase FOC89_25715 ENOG41068WN FOC89_25725 ENOG4105VEQ Cold shock protein FOC89_25745 ENOG410667J hydrolase FOC89_25790 ENOG4107V2S Transcriptional regulator FOC89_25795 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC89_25810 ENOG4107RSM transcriptional regulator FOC89_25815 ENOG4108RPX mosc domain containing protein FOC89_25830 ENOG4105BZ1 (ABC) transporter FOC89_25835 ENOG4105BZ1 (ABC) transporter FOC89_25855 ENOG4108JCI Transcriptional regulator FOC89_25885 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC89_25895 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC89_25900 ENOG4108KPJ rna polymerase sigma factor FOC89_25930 ENOG4105F32 YngK protein FOC89_25955 ENOG4105RD7 BadF BadG BcrA BcrD FOC89_25965 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC89_26000 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC89_26015 ENOG4105C1J atp-dependent rna helicase FOC89_26095 ENOG4105VTR Integrase FOC89_26120 ENOG41088CC tellurite resistance protein tehB FOC89_26135 ENOG4107RA9 decarboxylase FOC89_26140 ENOG41090HR transcriptional regulator FOC89_26170 ENOG4105CIN aminoacyl-histidine dipeptidase FOC89_26195 ENOG4107RF6 penicillin-binding protein FOC89_26200 ENOG4107RF6 penicillin-binding protein FOC89_26210 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC89_26215 ENOG4105ETE Transcriptional regulator (LacI family FOC89_26220 ENOG4105IE8 Alpha-ketoglutarate permease FOC89_26225 ENOG4105CK5 oxidoreductase FOC89_26250 ENOG4105D2N Aldolase FOC89_26255 ENOG4105DH8 myo-inositol catabolism FOC89_26270 ENOG4105CGH 5'-nucleotidase FOC89_26285 ENOG4105VZ8 Transcriptional regulator FOC89_26300 ENOG4108VXD carboxy-peptidase FOC89_26315 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC89_26320 ENOG41067SE Tetr family transcriptional regulator FOC89_26325 ENOG4105C5H ABC transporter FOC89_26330 ENOG4105BZU Histidine kinase FOC89_26355 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC89_26370 ENOG4105CJ1 ABC, transporter FOC89_26380 ENOG4107Z3H Transcriptional regulator, TetR family FOC89_26395 ENOG4105C1G acyl-Coa dehydrogenase FOC89_26400 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC89_26405 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC89_26410 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC89_26415 ENOG4105E39 Enoyl-CoA hydratase FOC89_26420 ENOG4107QX3 carboxylase FOC89_26425 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC89_26435 ENOG4105WCN acetyltransferase FOC89_26440 ENOG4105DBI uridine monophosphokinase FOC89_26455 ENOG4105DZ1 carboxypeptidase FOC89_26470 ENOG4105T9C HD domain FOC89_26480 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC89_26530 ENOG4105FQP Beta-lactamase FOC89_26540 ENOG4107Y80 Major Facilitator superfamily FOC89_26560 ENOG4105CUV Homoserine Kinase FOC89_26595 ENOG4105CPQ Dehydrogenase FOC89_26615 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC89_26625 ENOG4105DK7 lysyl-tRNA synthetase FOC89_26710 ENOG4105ETU transcriptional activator (TenA FOC89_26810 ENOG410667J hydrolase FOC89_26815 ENOG4105BZU Histidine kinase FOC89_26820 ENOG4107RF6 penicillin-binding protein FOC89_26855 ENOG4108HGU Histidine kinase FOC89_26870 ENOG4105CB2 alcohol dehydrogenase FOC89_26875 ENOG4105CJN penicillin-binding protein FOC89_26885 ENOG4105FQP Beta-lactamase FOC89_26920 ENOG4108V4B ThiJ pfpI FOC89_26950 ENOG4107Y80 Major Facilitator superfamily FOC89_26965 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC89_26985 ENOG4107Y9U Membrane FOC89_27025 ENOG4105FCD Major Facilitator FOC89_27040 ENOG4105E09 nadh pyrophosphatase FOC89_27045 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC89_27050 ENOG4108Z4K mutator MutT protein FOC89_27085 ENOG4108XI2 Domain of unknown function (DUF1963) FOC89_27105 ENOG4108NRW Phospholipase, patatin family FOC89_27110 ENOG4105KWG Pfam:DUF1696 FOC89_27145 ENOG4105PKS Excinuclease abc c subunit domain protein FOC89_27185 ENOG4107VFR oxidoreductase FOC89_27235 ENOG4105DY8 decarboxylase FOC89_27250 ENOG4108IUM Glycogen debranching enzyme FOC89_27275 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC89_27285 ENOG4105FDR Membrane FOC89_27345 ENOG4105MSI germination protein ypeb FOC89_27380 ENOG4107Z3H Transcriptional regulator, TetR family FOC89_27410 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC89_27430 ENOG4105E98 transcriptional regulator DeoR family FOC89_27455 ENOG4107QKR Dehydrogenase FOC89_27465 ENOG4107RUY (E1 component), alpha subunit FOC89_27475 ENOG4105E1F short-chain dehydrogenase reductase FOC89_27480 ENOG4105RHY Pfam:UPF0157 FOC89_27485 ENOG4105DBI uridine monophosphokinase FOC89_27515 ENOG4107SQ8 Glycine betaine FOC89_27520 ENOG4108IJ7 Glycine betaine FOC89_27550 ENOG41082BV acetyltransferase FOC89_27555 ENOG4108M1A Chitin-binding protein FOC89_27575 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC89_27600 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC89_27630 ENOG4108Z7F N-acetyltransferase FOC89_27650 ENOG4105EEM helicase FOC89_27670 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC89_27715 ENOG4108M1A Chitin-binding protein FOC89_27735 ENOG4105BZG amino acid carrier protein FOC89_27740 ENOG4105C26 Dehydrogenase FOC89_27745 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC89_27750 ENOG4105CTU Proline racemase FOC89_27755 ENOG4105CTU Proline racemase FOC89_27760 ENOG41080HI glycine oxidase FOC89_27770 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC89_27800 ENOG4107T5V SNARE associated Golgi FOC89_27815 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC89_27820 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC89_27835 ENOG4105DTQ mandelate racemase muconate lactonizing FOC89_27880 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC89_27885 ENOG4105BZU Histidine kinase FOC89_27890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_27925 ENOG4105DPN Oligoendopeptidase f FOC89_27935 ENOG4105EPR degv family FOC89_27975 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC89_27980 ENOG4106K7D Major facilitator family transporter FOC89_28000 ENOG4107BMA Transglycosylase associated protein FOC89_28015 ENOG41089UC methyltransferase, type 11 FOC89_28050 ENOG4105CHM Aminotransferase FOC89_28065 ENOG4108ZMI UPF0477 protein FOC89_28080 ENOG4105DVE abc transporter atp-binding protein FOC89_28130 ENOG4105C02 permease FOC89_28140 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC89_28145 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC89_28150 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC89_28175 ENOG4105E09 nadh pyrophosphatase FOC89_28195 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC89_28245 ENOG4107VC0 DNA alkylation repair enzyme FOC89_28265 ENOG4108ZCF integral membrane protein FOC89_28270 ENOG4105E0M Sulfatase FOC89_28275 ENOG4105C5H ABC transporter FOC89_28285 ENOG4105EYF MMPL domain protein FOC89_28290 ENOG41082JN Transcriptional regulator FOC89_28310 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC89_28320 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC89_28340 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC89_28355 ENOG41069ER domain protein FOC89_28365 ENOG4105CY2 Citrate transporter FOC89_28370 ENOG4105E39 Enoyl-CoA hydratase FOC89_28375 ENOG4105J5T Amp-dependent synthetase and ligase FOC89_28380 ENOG4108JUB Transcriptional regulator FOC89_28395 ENOG4105D4B ABC, transporter FOC89_28405 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC89_28415 ENOG4105DKT Transcriptional regulator FOC89_28420 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC89_28430 ENOG41061GT Aldolase FOC89_28450 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC89_28480 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC89_28485 ENOG4105II7 pyrroline-5-carboxylate reductase FOC89_28505 ENOG4107258 Transcriptional regulator FOC89_28515 ENOG4105E0Y RtcB Protein FOC89_28520 ENOG4105ECK Fatty Acid Desaturase FOC89_28525 ENOG4105G6Z alkaline phosphatase FOC89_28535 ENOG4105VMP Transcriptional regulator FOC89_28550 ENOG41090T1 Membrane FOC89_28560 ENOG4108WCX response regulator FOC89_28570 ENOG41068WN FOC89_28595 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC89_28610 ENOG4105CSH Transporter FOC89_28620 ENOG4105CKK Glycosyl transferase, family 2 FOC89_28635 ENOG4105CKK Glycosyl transferase, family 2 FOC89_28645 ENOG4105C8Y Acetylornithine aminotransferase FOC89_28685 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC89_28695 ENOG4108TVJ Nitroreductase FOC89_28700 ENOG4105FS7 Transcriptional regulator FOC89_28720 ENOG4105ERH Fumarylacetoacetate hydrolase FOC89_28735 ENOG41082UD thioesterase Superfamily protein FOC89_28740 ENOG4105CEY Amp-dependent synthetase and ligase FOC89_28745 ENOG4105CHU acetyl-coa acetyltransferase FOC89_28750 ENOG4105E39 Enoyl-CoA hydratase FOC89_28755 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC89_28760 ENOG4105CS2 ec 3.2.1.21 FOC89_28765 ENOG4105VCP PTS System FOC89_28770 ENOG4108QVC Component IIC FOC89_28775 ENOG4107XMU Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC89_28785 ENOG4105VZJ PTS System FOC89_28795 ENOG4105G9B Transcriptional regulator FOC89_28800 ENOG4105D2S major facilitator superfamily FOC89_28805 ENOG4105EFZ amidohydrolase FOC89_28835 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC89_28840 ENOG4105CMR udp-glucose 4-epimerase FOC89_28845 ENOG4105C19 ABC transporter FOC89_28875 ENOG4108XET gCN5-related N-acetyltransferase FOC89_28940 ENOG410635A Membrane FOC89_28945 ENOG4105KNA -acetyltransferase FOC89_28950 ENOG4108IQI permease FOC89_28960 ENOG4105F1N DNA alkylation repair FOC89_28990 ENOG4107RF6 penicillin-binding protein FOC89_29030 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC89_29035 ENOG4107258 Transcriptional regulator FOC89_29045 ENOG4106N3A copper homeostasis protein cutc FOC89_29050 ENOG4108ZRV stage ii sporulation protein p FOC89_29055 ENOG4108ZHR arsR family transcriptional regulator FOC89_29065 ENOG4105FDT acyl-CoA dehydrogenase FOC89_29080 ENOG4105DWD nucleoside recognition domain protein FOC89_29110 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC89_29175 ENOG4105E2A Dehydrogenase FOC89_29185 ENOG4108IJ0 Aspartate ammonia-lyase FOC89_29190 ENOG4105HDK L-asparaginase FOC89_29195 ENOG4108IMY Transcriptional regulator FOC89_29215 ENOG4108B31 Spore germination protein FOC89_29225 ENOG4105BZU Histidine kinase FOC89_29250 ENOG41075H3 AraC family transcriptional regulator FOC89_29265 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC89_29270 ENOG4105CUB amino acid FOC89_29280 ENOG4105II7 pyrroline-5-carboxylate reductase FOC89_29295 ENOG4108NHD germination protein FOC89_29300 ENOG4108Q8B Spore germination protein FOC89_29320 ENOG4105CSV Glutaminase FOC89_29335 ENOG4105CGH 5'-nucleotidase FOC89_29340 ENOG4105CH6 catalase FOC89_29350 ENOG4105CHJ isochorismatase hydrolase FOC89_29355 ENOG4105CHJ isochorismatase hydrolase FOC89_29375 ENOG41090MY MarR family Transcriptional regulator FOC89_29410 ENOG4108606 TspO/MBR family FOC89_29415 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC89_29430 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC89_29435 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC89_29450 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC89_29455 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC89_29490 ENOG4105D6J arsenicaL-resistance protein FOC89_29495 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC89_29500 ENOG41085FC arsR family transcriptional regulator FOC89_29520 ENOG4105BZU Histidine kinase FOC89_29525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_29540 ENOG4107P5I polyketide synthase FOC89_29545 ENOG4108IG5 Transcriptional regulator FOC89_29550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC89_29555 ENOG4108YXU transcriptional regulator AsnC family FOC89_29630 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC89_29635 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC89_29645 ENOG4105IIP Membrane FOC89_29660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC89_29665 ENOG41062D9 Histidine kinase FOC89_29690 ENOG4105K6H D-cysteine desulfhydrase FOC89_29715 ENOG4108NNI Beta-lactamase domain-containing protein FOC89_29720 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC89_29730 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC89_29745 ENOG4105C88 aminopeptidase FOC89_29755 ENOG4105W1Y Transcriptional regulator FOC89_29775 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC89_29780 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC89_29795 ENOG4105BZU Histidine kinase FOC89_29805 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC89_29810 ENOG4105DJB Major Facilitator Superfamily FOC89_29815 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC89_29820 ENOG4107QR9 Iron-sulfur cluster binding protein FOC89_29830 ENOG4106P55 Transcriptional regulator FOC89_29840 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC89_29870 ENOG4105TRI Hydrolase FOC89_29905 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC89_29940 ENOG4105C44 Serine transporter FOC89_29945 ENOG4105EJQ L-serine dehydratase FOC89_29960 ENOG4108JPW Aminotransferase FOC89_29970 ENOG4105C45 hydrogenase expression formation protein (HypE) FOC89_29975 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC89_29985 ENOG4105DVH amino acid FOC89_30000 ENOG4108JQ1 Dehydrogenase FOC89_30020 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC89_30025 ENOG410874W AraC family transcriptional regulator FOC89_30045 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC89_30085 ENOG4108ISG Major Facilitator FOC89_30095 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC89_30100 ENOG4105CZM Major Facilitator FOC89_30110 ENOG4105RXJ FOC89_30115 ENOG4105KPY Small multidrug resistance protein FOC89_30120 ENOG4105KBX Transcriptional regulator, TetR family FOC89_30130 ENOG4105CRW Short chain fatty acid transporter FOC89_30140 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC89_30175 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)