locus-tag class description FOC90_00010 ENOG41067QW Transcriptional regulator FOC90_00135 ENOG4105EQI Metal Dependent Phosphohydrolase FOC90_00210 ENOG4105D9P serine threonine protein kinase FOC90_00630 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOC90_00735 ENOG4105C4R Atp-dependent dna helicase FOC90_01010 ENOG4105C2M dna polymerase I FOC90_01300 ENOG4107XK4 dna polymerase iii subunits gamma and tau FOC90_01570 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC90_01575 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC90_01640 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC90_01850 ENOG4108VXD carboxy-peptidase FOC90_02010 ENOG4105IEH endo-beta-N-acetylglucosaminidase FOC90_02095 ENOG4105MZU cell filamentation protein FOC90_02145 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC90_02150 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC90_02275 ENOG4105C2M dna polymerase I FOC90_02300 ENOG410906U SprT-like FOC90_02565 ENOG4108IBT Inherit from COG: transposase FOC90_02605 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC90_02610 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC90_02615 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC90_02620 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FOC90_02645 ENOG4105D9N nucleoside FOC90_02655 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC90_02665 ENOG4107TS3 membrane protein, TerC FOC90_02675 ENOG4106FN3 tellurium resistance protein FOC90_02680 ENOG4106FN3 tellurium resistance protein FOC90_02705 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC90_02890 ENOG4105ZMH deoxynucleoside kinase FOC90_02910 ENOG4105GR3 Histidine kinase FOC90_02915 ENOG4105BZU Histidine kinase FOC90_02930 ENOG4105C0D helicase FOC90_02935 ENOG4105K6T rare lipoprotein A FOC90_02980 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FOC90_02985 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC90_02990 ENOG4105C4R Atp-dependent dna helicase FOC90_03010 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FOC90_03015 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOC90_03050 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FOC90_03060 ENOG4108UUM single-stranded DNA-binding protein FOC90_03175 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC90_03235 ENOG4107JM4 Tetratricopeptide repeat FOC90_03275 ENOG4105GJD protein, conserved in bacteria FOC90_03280 ENOG4105EKQ RNA-directed DNA polymerase FOC90_03290 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOC90_03305 ENOG4105C0B DNA polymerase III (alpha subunit) FOC90_03315 ENOG4105C0B DNA polymerase III (alpha subunit) FOC90_03385 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FOC90_03410 ENOG4105K4W Could be involved in septation (By similarity) FOC90_03440 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FOC90_03685 ENOG4105YWU small acid-soluble spore protein FOC90_03690 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC90_03695 ENOG4105CUB amino acid FOC90_03700 ENOG4105II7 pyrroline-5-carboxylate reductase FOC90_03710 ENOG4108Q8B Spore germination protein FOC90_03745 ENOG4106A3M Cytochrome p-450 FOC90_03760 ENOG4105CGH 5'-nucleotidase FOC90_03770 ENOG4105CHJ isochorismatase hydrolase FOC90_03795 ENOG41090MY MarR family Transcriptional regulator FOC90_03820 ENOG4105F6J Alpha beta hydrolase fold FOC90_03835 ENOG4108606 TspO/MBR family FOC90_03840 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC90_03855 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC90_03860 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC90_03875 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC90_03880 ENOG4105DSE periplasmic solute binding protein FOC90_03885 ENOG4105CC5 ABC transporter FOC90_03890 ENOG4105DIK (ABC) transporter FOC90_03910 ENOG4105D6J arsenicaL-resistance protein FOC90_03915 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC90_03920 ENOG41085FC arsR family transcriptional regulator FOC90_03930 ENOG4105EGI Transcriptional regulator FOC90_03970 ENOG4105VZ8 Transcriptional regulator FOC90_03980 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FOC90_03990 ENOG4107P5I polyketide synthase FOC90_03995 ENOG4108IG5 Transcriptional regulator FOC90_04000 ENOG4105CHR reductase FOC90_04005 ENOG4108YXU transcriptional regulator AsnC family FOC90_04045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_04090 ENOG4105DNP FAD linked oxidase domain protein FOC90_04100 ENOG4105C19 ABC transporter FOC90_04130 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC90_04135 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC90_04145 ENOG4105K6H D-cysteine desulfhydrase FOC90_04165 ENOG4105JQZ Methyltransferase FOC90_04185 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC90_04205 ENOG4105BZU Histidine kinase FOC90_04220 ENOG4108U05 Transcriptional regulator FOC90_04225 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOC90_04235 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC90_04260 ENOG4108JQ1 Dehydrogenase FOC90_04265 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOC90_04280 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC90_04285 ENOG410874W AraC family transcriptional regulator FOC90_04300 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC90_04310 ENOG4108IG5 Transcriptional regulator FOC90_04415 ENOG4107EV6 Inherit from COG: YD repeat protein FOC90_04440 ENOG4108VXD carboxy-peptidase FOC90_04445 ENOG4105PNM synthesis protein FOC90_04455 ENOG4108ISG Major Facilitator FOC90_04470 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC90_04475 ENOG4105CZM Major Facilitator FOC90_04485 ENOG4105CRW Short chain fatty acid transporter FOC90_04500 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC90_04560 ENOG4108K8S endonuclease I FOC90_04570 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC90_04575 ENOG4108Z66 YbaK ebsC protein FOC90_04595 ENOG4105KVH Transcriptional regulator FOC90_04600 ENOG4108RCM Nitroreductase FOC90_04630 ENOG4108PSK reductase FOC90_04695 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC90_04700 ENOG4105DKQ ROK family FOC90_04705 ENOG4106UW1 Major Facilitator superfamily FOC90_04710 ENOG4108UW5 maltose o-acetyltransferase FOC90_04720 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC90_04770 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FOC90_04780 ENOG4105EV4 Multidrug resistance protein mdtH FOC90_04810 ENOG4105C37 (CBS) domain FOC90_04835 ENOG4105DDN Pentapeptide repeat-containing protein FOC90_04840 ENOG4105XDF Protein of unknown function (DUF1272) FOC90_04845 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC90_04850 ENOG4105CMG Carbohydrate kinase FOC90_04855 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC90_04865 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC90_04870 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC90_04890 ENOG4105C44 Serine transporter FOC90_04920 ENOG4105KVH Transcriptional regulator FOC90_04925 ENOG4108TZY GntR Family Transcriptional Regulator FOC90_04930 ENOG4105D9R oxidoreductase FOC90_04975 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC90_04990 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC90_04995 ENOG4105KVH Transcriptional regulator FOC90_05000 ENOG4107SCK Monooxygenase FOC90_05070 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC90_05105 ENOG4105H3G oxidoreductase FOC90_05140 ENOG4105CIS alcohol dehydrogenase FOC90_05175 ENOG4108TN2 lmbE family FOC90_05185 ENOG4107R3E Citrate transporter FOC90_05195 ENOG4105WCN acetyltransferase FOC90_05200 ENOG4105NX3 Membrane FOC90_05220 ENOG4107CUJ Protein of unknown function (DUF2690) FOC90_05230 ENOG4107V2S Transcriptional regulator FOC90_05250 ENOG4105C98 muts2 protein FOC90_05260 ENOG4105E5K Alpha-amylase FOC90_05265 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC90_05270 ENOG4105DPN Oligoendopeptidase f FOC90_05305 ENOG4108A04 Beta-lactamase FOC90_05330 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC90_05340 ENOG41082BM Transcriptional regulator, arsr family FOC90_05345 ENOG4105CIS alcohol dehydrogenase FOC90_05365 ENOG4105C09 Bile acid FOC90_05370 ENOG4105CQB FAD linked oxidase domain protein FOC90_05390 ENOG4105CEP NADH dehydrogenase FOC90_05415 ENOG4105D2T synthase FOC90_05430 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FOC90_05435 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOC90_05440 ENOG4105C1B dTDP-glucose 4-6-dehydratase FOC90_05445 ENOG4105C5E polysaccharide biosynthesis protein FOC90_05470 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FOC90_05475 ENOG4108M1A Chitin-binding protein FOC90_05485 ENOG4105E1K spore germination protein FOC90_05505 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOC90_05520 ENOG4105FAW cDP-glucose 4,6-dehydratase FOC90_05570 ENOG4105BZU Histidine kinase FOC90_05580 ENOG41067SE Tetr family transcriptional regulator FOC90_05585 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC90_05595 ENOG4108VXD carboxy-peptidase FOC90_05600 ENOG4107DUR UPF0457 protein FOC90_05620 ENOG4105BZU Histidine kinase FOC90_05630 ENOG4105KT7 mgtC SapB transporter FOC90_05640 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC90_05645 ENOG41073R8 VanW family FOC90_05655 ENOG4108R1P FOC90_05675 ENOG4105VEQ Cold shock protein FOC90_05695 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC90_05715 ENOG410904N short-chain dehydrogenase reductase FOC90_05725 ENOG4106IQC argininosuccinate lyase FOC90_05740 ENOG4108IA2 Sodium pantothenate symporter FOC90_05750 ENOG4105C26 Dehydrogenase FOC90_05755 ENOG4105CHR reductase FOC90_05765 ENOG4105EWU Squalene--hopene cyclase FOC90_05775 ENOG4105FR1 rard protein FOC90_05780 ENOG410696E Membrane FOC90_05795 ENOG4105D1F ATP-binding protein FOC90_05805 ENOG4108ZAF Molybdopterin FOC90_05810 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC90_05815 ENOG4105D06 uba thif-type nad fad binding protein FOC90_05820 ENOG4105TMB Formate nitrite transporter FOC90_05830 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC90_05835 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC90_05885 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC90_05985 ENOG4108C33 Resolvase FOC90_06010 ENOG4105WXW Antirepressor FOC90_06025 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC90_06065 ENOG4108PNI recT protein FOC90_06070 ENOG4108NF7 phage-type endonuclease FOC90_06130 ENOG4108JB9 formate dehydrogenase FOC90_06205 ENOG4107QJT sodium dicarboxylate symporter FOC90_06210 ENOG4108KGH TRANSCRIPTIONal FOC90_06220 ENOG4105EMN RNA polymerase sigma factor FOC90_06230 ENOG4105CIG ABC transporter FOC90_06250 ENOG4105D9R oxidoreductase FOC90_06260 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC90_06265 ENOG4105K4P CoA-binding domain protein FOC90_06270 ENOG4105C0H protease FOC90_06275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_06285 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC90_06295 ENOG4105W8X HesB YadR YfhF-family protein FOC90_06320 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC90_06325 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC90_06335 ENOG4108JJB ABC transporter FOC90_06340 ENOG4108I0Z Aconitate hydratase FOC90_06370 ENOG4105E5W Transporter FOC90_06380 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC90_06400 ENOG4107F3J Amp-dependent synthetase and ligase FOC90_06405 ENOG4107ZYJ bioY protein FOC90_06410 ENOG4105CEY Amp-dependent synthetase and ligase FOC90_06415 ENOG4108IMY Transcriptional regulator FOC90_06450 ENOG4107AYK membrAne FOC90_06460 ENOG4105BZU Histidine kinase FOC90_06465 ENOG4105FBA Phospholipase Carboxylesterase FOC90_06470 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC90_06475 ENOG4105CK7 Sodium proline symporter FOC90_06485 ENOG4105CBC glutamate synthase FOC90_06490 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC90_06495 ENOG4108VJ1 Transcriptional regulator (CarD family FOC90_06500 ENOG4108903 Formimidoylglutamase FOC90_06555 ENOG4107QIV Cytochrome c biogenesis protein FOC90_06575 ENOG4105CJ1 ABC, transporter FOC90_06595 ENOG4107RSM transcriptional regulator FOC90_06605 ENOG41067MG lrgb family FOC90_06645 ENOG4105BZ1 (ABC) transporter FOC90_06650 ENOG4105BZ1 (ABC) transporter FOC90_06685 ENOG4108HW3 (ABC) transporter FOC90_06690 ENOG4105CGH 5'-nucleotidase FOC90_06700 ENOG4108SVB resolvase FOC90_06720 ENOG4105K7K Transcriptional regulator FOC90_06730 ENOG4105E4C Lytic transglycosylase catalytic FOC90_06735 ENOG41065S2 pneumococcal vaccine antigen FOC90_06770 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOC90_06775 ENOG4105C5F glutamine synthetase FOC90_06780 ENOG4105KV4 Transcriptional regulator FOC90_06785 ENOG4105CXI aluminum resistance protein FOC90_06790 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC90_06795 ENOG4105EN6 Membrane FOC90_06805 ENOG4106F1P AAA ATPase, central domain protein FOC90_06835 ENOG41069ER domain protein FOC90_06840 ENOG4105DM4 PTS System FOC90_06845 ENOG4105DE4 1-phosphofructokinase FOC90_06850 ENOG4105E98 transcriptional regulator DeoR family FOC90_06855 ENOG4107QW4 alcohol dehydrogenase FOC90_06860 ENOG4108SJC Membrane FOC90_06870 ENOG4105C85 amino acid FOC90_06890 ENOG4105TMB Formate nitrite transporter FOC90_06895 ENOG4105K70 DNA-binding protein FOC90_06905 ENOG4105C59 p-type ATPase FOC90_06910 ENOG410681U heavy metal transport detoxification protein FOC90_06915 ENOG4105VPX protein, conserved in bacteria FOC90_06935 ENOG4105NIV Esterase FOC90_06940 ENOG4105E0A ABC, transporter FOC90_06960 ENOG4105CGK Exodeoxyribonuclease III FOC90_06970 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC90_06975 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC90_07005 ENOG4105BZU Histidine kinase FOC90_07040 ENOG41067MG lrgb family FOC90_07060 ENOG4105C8Q Methyl-accepting chemotaxis FOC90_07075 ENOG4105F0V Cell wall hydrolase FOC90_07085 ENOG4105E0M Sulfatase FOC90_07090 ENOG410890F Dynamin family FOC90_07125 ENOG4105DQU oxidoreductase, subunit beta FOC90_07130 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC90_07135 ENOG4108IGT Dipeptidase FOC90_07140 ENOG4105MCT stage V sporulation protein S FOC90_07145 ENOG4105D48 metallophosphoesterase FOC90_07165 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC90_07180 ENOG4105XZV Protein of unknown function (DUF3243) FOC90_07185 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC90_07205 ENOG4105UIB (ABC) transporter FOC90_07210 ENOG4108JQ9 ABC transporter FOC90_07215 ENOG4105DIH basic membrane FOC90_07220 ENOG4105FDP GntR family transcriptional regulator FOC90_07225 ENOG4105CNU cell division protein FtsK FOC90_07235 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC90_07245 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC90_07255 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC90_07260 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC90_07265 ENOG4108IBT Inherit from COG: transposase FOC90_07385 ENOG4105VEQ Cold shock protein FOC90_07425 ENOG4105CDU Replicative dna helicase FOC90_07470 ENOG4108IMY Transcriptional regulator FOC90_07495 ENOG4105E35 Dipicolinate synthase subunit A FOC90_07505 ENOG4105C1V Peptidase, M16 FOC90_07525 ENOG4105DTN riboflavin biosynthesis protein ribF FOC90_07540 ENOG4105W7A Protein of unknown function (DUF503) FOC90_07550 ENOG4105VHM ribosomal protein FOC90_07555 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC90_07560 ENOG4105CHV Transcription elongation factor NusA FOC90_07570 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC90_07580 ENOG4105DZP Membrane-associated zinc metalloprotease FOC90_07585 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC90_07590 ENOG4105KNE Phosphatidate cytidylyltransferase FOC90_07595 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC90_07605 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC90_07635 ENOG4108HE4 integrase family FOC90_07645 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC90_07650 ENOG4105C79 DNA protecting protein DprA FOC90_07655 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC90_07670 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC90_07695 ENOG4105VB6 UPF0109 protein FOC90_07715 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC90_07720 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC90_07735 ENOG4105CHR reductase FOC90_07740 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC90_07755 ENOG4105CB5 ATP-dependent DNA helicase recG FOC90_07760 ENOG4105DP4 dak2 domain fusion protein ylov FOC90_07765 ENOG4108ZAA Alkaline-shock protein FOC90_07780 ENOG4105FJ0 thiamine FOC90_07785 ENOG4105DJV ribulose-phosphate 3-epimerase FOC90_07790 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC90_07795 ENOG4105D9P serine threonine protein kinase FOC90_07800 ENOG4108ZF3 Phosphatase FOC90_07810 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC90_07825 ENOG4105C25 Primosomal protein n' FOC90_07830 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC90_07850 ENOG4105DSJ YicC domain protein FOC90_07865 ENOG4105DC7 peptidase M24 FOC90_07945 ENOG4105C34 Pseudouridine synthase FOC90_07970 ENOG4105DBK s4 domain protein FOC90_07975 ENOG41067XK integral membrane protein FOC90_07985 ENOG4105DFA alanine racemase domain protein FOC90_07990 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC90_07995 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC90_08005 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC90_08015 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC90_08020 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC90_08030 ENOG4105D4A Cell wall formation (By similarity) FOC90_08040 ENOG4105CNI cell division protein FtsW FOC90_08055 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC90_08060 ENOG4105CJN penicillin-binding protein FOC90_08065 ENOG4105CJN penicillin-binding protein FOC90_08105 ENOG4105KNH Nucleic acid-binding protein FOC90_08115 ENOG41063PX domain protein FOC90_08120 ENOG4105D78 K07001 NTE family protein FOC90_08125 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC90_08135 ENOG4106H78 methyltransferase FOC90_08155 ENOG4107TB6 phosphoglycerate mutase FOC90_08170 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC90_08220 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC90_08225 ENOG4105CNI cell division protein FtsW FOC90_08240 ENOG4108IAB Phoh family FOC90_08260 ENOG4105QA2 FOC90_08265 ENOG4105CI3 gtp-binding protein typa FOC90_08275 ENOG4105ECY inositol monophosphatase FOC90_08295 ENOG4105CXN decarboxylase FOC90_08345 ENOG4105CPP Dehydrogenase, E1 component FOC90_08360 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC90_08365 ENOG4108X4Q Hydrolase FOC90_08375 ENOG4105CN5 Metallo-Beta-Lactamase FOC90_08380 ENOG4107ZYR domain protein FOC90_08415 ENOG4108XRC Protein of unknown function (DUF458) FOC90_08425 ENOG4107IN1 Protein of unknown function (DUF1797) FOC90_08440 ENOG4105EPM Diguanylate phosphodiesterase FOC90_08445 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC90_08525 ENOG4108HGU Histidine kinase FOC90_08535 ENOG4105CHM Aminotransferase FOC90_08540 ENOG4105FKQ transcriptional regulator FOC90_08545 ENOG4105EG2 ABC transporter, permease FOC90_08555 ENOG4107FKK extracellular solute-binding protein family 1 FOC90_08565 ENOG4105CG3 alpha amylase, catalytic region FOC90_08610 ENOG4105CHU acetyl-coa acetyltransferase FOC90_08645 ENOG4105K7K Transcriptional regulator FOC90_08650 ENOG4105DTD Dehydrogenase FOC90_08670 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC90_08695 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC90_08710 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC90_08720 ENOG4105BZU Histidine kinase FOC90_08740 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC90_08755 ENOG4105CID antiterminator FOC90_08775 ENOG4105CE4 GlcNAc 6-P deacetylase FOC90_08810 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC90_08815 ENOG4105PTM secreted protein FOC90_08820 ENOG4105J7I hydrolase FOC90_08830 ENOG4105G6R Stage v sporulation protein ae FOC90_08840 ENOG4105CZ3 stage V sporulation protein ad FOC90_08845 ENOG41090VF Stage v sporulation protein ac FOC90_08865 ENOG4105C8J )-transporter FOC90_08870 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC90_08880 ENOG41082AN stage II sporulation protein FOC90_08885 ENOG4105DZ1 carboxypeptidase FOC90_08890 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC90_08895 ENOG4105DVE abc transporter atp-binding protein FOC90_08930 ENOG4105D7N magnesium and cobalt transport protein CorA FOC90_08955 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC90_08965 ENOG4105I3K Ferric uptake regulator, Fur family FOC90_08970 ENOG4105MZ9 stage II sporulation protein m FOC90_08990 ENOG4105CPC Aldo Keto reductase FOC90_09000 ENOG4105RHY Pfam:UPF0157 FOC90_09020 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC90_09030 ENOG4105ETE Transcriptional regulator (LacI family FOC90_09035 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC90_09055 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC90_09060 ENOG4108R6K riboflavin synthase, subunit alpha FOC90_09085 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC90_09090 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC90_09105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC90_09115 ENOG4105DFD Na H antiporter FOC90_09120 ENOG4105CGH 5'-nucleotidase FOC90_09145 ENOG4105DBV ornithine carbamoyltransferase FOC90_09160 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC90_09175 ENOG4108IXY short-chain dehydrogenase reductase FOC90_09180 ENOG41069FQ Metallo-beta-lactamase superfamily FOC90_09185 ENOG4105II7 pyrroline-5-carboxylate reductase FOC90_09190 ENOG4105EJQ L-serine dehydratase FOC90_09220 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC90_09240 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC90_09245 ENOG4105D9U N-acetyltransferase FOC90_09260 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC90_09265 ENOG4108QEG Membrane FOC90_09270 ENOG4105CDA abc transporter atp-binding protein FOC90_09275 ENOG4105E5Q amino acid AbC transporter FOC90_09280 ENOG4108HW3 (ABC) transporter FOC90_09290 ENOG4105G7B Protein of unknown function (DUF2992) FOC90_09300 ENOG4108QY0 Membrane FOC90_09310 ENOG4105C7S Dehydrogenase FOC90_09315 ENOG4105CPP Dehydrogenase, E1 component FOC90_09335 ENOG4107RDP Dehydrogenase FOC90_09345 ENOG4108JUB Transcriptional regulator FOC90_09355 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC90_09405 ENOG4108C33 Resolvase FOC90_09440 ENOG4107QQR Sporulation FOC90_09445 ENOG4105S1Z Stage IV sporulation protein B FOC90_09450 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC90_09455 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOC90_09460 ENOG4105DX0 Hemolysin A FOC90_09470 ENOG4105CTB Polyprenyl synthetase FOC90_09495 ENOG4108ZSR alkaline shock protein FOC90_09500 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC90_09525 ENOG410644B Stage III sporulation protein af FOC90_09535 ENOG4105KQ4 Stage iii sporulation protein ad FOC90_09540 ENOG4108CQH stage III sporulation protein AC FOC90_09545 ENOG4105KR5 Stage iii sporulation protein FOC90_09550 ENOG4105CD2 stage iii sporulation protein aa FOC90_09575 ENOG4105DC7 peptidase M24 FOC90_09590 ENOG4105CBJ Metal-dependent enzyme FOC90_09600 ENOG4107YBY Hydrolase FOC90_09630 ENOG41082GG biotin lipoate A B protein ligase FOC90_09635 ENOG4105WZW rhodanese family FOC90_09660 ENOG41080TC multidrug resistance protein FOC90_09700 ENOG4105C0D helicase FOC90_09785 ENOG4107R6U sodium dicarboxylate symporter FOC90_09820 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC90_09825 ENOG4105C3R Methionine synthase FOC90_09835 ENOG4105C28 cystathionine FOC90_09840 ENOG4105C28 cystathionine FOC90_09860 ENOG4105C5X domain protein FOC90_09870 ENOG4105DKQ ROK family FOC90_09880 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC90_09895 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC90_09900 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC90_09905 ENOG4105C8U phosphate abc transporter FOC90_09910 ENOG4105C8U phosphate abc transporter FOC90_09920 ENOG4107RF6 penicillin-binding protein FOC90_09930 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC90_09955 ENOG4105N80 Ferric uptake regulator, Fur family FOC90_09965 ENOG4105FDK ABC transporter FOC90_09970 ENOG4108JYZ YitT family FOC90_09975 ENOG41069ZM Protein of unknown function (DUF2624) FOC90_10000 ENOG4105EGD dinuclear metal center protein, YbgI family FOC90_10015 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC90_10020 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC90_10025 ENOG4107XJU UPF0178 protein FOC90_10050 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC90_10055 ENOG4105KG3 cytidine deaminase FOC90_10060 ENOG4107YR5 Diacylglycerol kinase FOC90_10070 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC90_10075 ENOG4105C9A Phoh family FOC90_10085 ENOG41068P3 sporulation protein YqfC FOC90_10095 ENOG4105KTH gatB Yqey FOC90_10105 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC90_10110 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC90_10140 ENOG4105CSA Coproporphyrinogen iii oxidase FOC90_10145 ENOG4105KVH Transcriptional regulator FOC90_10170 ENOG4105TQK DNA polymerase iii, delta' subunit FOC90_10180 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC90_10185 ENOG4108UK2 deaminase FOC90_10190 ENOG4105KQC Competence protein FOC90_10200 ENOG4105DXX methyltransferase FOC90_10210 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC90_10220 ENOG410812S Rna-binding protein FOC90_10230 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC90_10235 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC90_10250 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC90_10270 ENOG4108TVJ Nitroreductase FOC90_10285 ENOG4105G6Z alkaline phosphatase FOC90_10290 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOC90_10295 ENOG4108MUZ hydrolase FOC90_10330 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC90_10335 ENOG4105MIR Phenylalanine 4-monooxygenase FOC90_10345 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC90_10385 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC90_10390 ENOG4108V5C ABC transporter FOC90_10400 ENOG4105C0A alcohol dehydrogenase FOC90_10405 ENOG4105C28 cystathionine FOC90_10435 ENOG4107XRG penicillin-binding protein FOC90_10445 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOC90_10455 ENOG4105CFP Peptidase U32 FOC90_10460 ENOG4105XYU peptidase (U32 family) FOC90_10470 ENOG4105HHA aminodeoxychorismate lyase FOC90_10490 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC90_10500 ENOG4105C02 permease FOC90_10515 ENOG41060CR FOC90_10520 ENOG4105C7H Helicase, RecD TraA family FOC90_10530 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC90_10535 ENOG4105C3J Cysteine desulfurase FOC90_10545 ENOG4105D1H recombination factor protein RarA FOC90_10550 ENOG4108VCI transcription factor, rsfa family FOC90_10555 ENOG4105CUZ uba thif-type nad fad binding protein FOC90_10565 ENOG4105CUT histidyl-tRNA synthetase FOC90_10585 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC90_10595 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC90_10600 ENOG41076HS cation diffusion facilitator family transporter FOC90_10605 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC90_10615 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC90_10620 ENOG4108QG2 Membrane FOC90_10630 ENOG4105VIE preprotein translocase, subunit YajC FOC90_10645 ENOG41061AI Protein of unknown function (DUF2905) FOC90_10660 ENOG4108HUF Transporter FOC90_10690 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC90_10695 ENOG4108IYU L-aspartate oxidase FOC90_10710 ENOG4108RPX mosc domain containing protein FOC90_10720 ENOG4105CQC Prephenate dehydratase FOC90_10740 ENOG4105EWM Histidine kinase FOC90_10765 ENOG4105X36 (ribosomal) protein FOC90_10775 ENOG4105C03 ribonuclease FOC90_10790 ENOG4107QMS site-determining protein FOC90_10810 ENOG4105DFF Rod shape-determining protein mreb FOC90_10830 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC90_10835 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC90_10845 ENOG41068KH stage VI sporulation protein D FOC90_10855 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC90_10880 ENOG4105K56 Transcriptional regulator FOC90_10900 ENOG4108IUQ atp-dependent protease FOC90_10925 ENOG4108QCI YvbH-like oligomerisation region FOC90_10950 ENOG4105M59 Phosphodiesterase, mj0936 family FOC90_10965 ENOG4108XJQ germination protein FOC90_10975 ENOG4108PCX Major Facilitator FOC90_10985 ENOG4105KBX Transcriptional regulator, TetR family FOC90_10995 ENOG4105PFC Transcriptional regulator FOC90_11005 ENOG4105DZC cytosine deaminase FOC90_11010 ENOG41067S9 phage shock protein C, PspC FOC90_11015 ENOG4108JCI Transcriptional regulator FOC90_11025 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC90_11030 ENOG4108Z40 Transcriptional regulator FOC90_11035 ENOG4105RHA ABC transporter, permease FOC90_11040 ENOG4108IUX (ABC) transporter FOC90_11045 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC90_11050 ENOG4105ER2 Ompa motb domain protein FOC90_11055 ENOG4105E14 MotA TolQ exbB proton channel FOC90_11060 ENOG4108VXD carboxy-peptidase FOC90_11070 ENOG4105E33 succinate dehydrogenase FOC90_11080 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC90_11095 ENOG4105K63 Thioredoxin FOC90_11100 ENOG4105C10 Electron transfer flavoprotein FOC90_11105 ENOG4105BZJ Electron transfer flavoprotein FOC90_11110 ENOG41060WC Enoyl-CoA hydratase FOC90_11115 ENOG4107Z3H Transcriptional regulator, TetR family FOC90_11120 ENOG4105CEY Amp-dependent synthetase and ligase FOC90_11130 ENOG4105J76 Periplasmic binding protein FOC90_11135 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC90_11175 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC90_11190 ENOG4105DR4 Methyltransferase FOC90_11200 ENOG4105KFN sortase, SrtB family FOC90_11205 ENOG4105E0A ABC, transporter FOC90_11220 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC90_11230 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC90_11240 ENOG4105FE9 pseudouridine synthase FOC90_11250 ENOG4105DCG PHP domain protein FOC90_11265 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOC90_11285 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC90_11295 ENOG4108RWN rrna methyltransferase FOC90_11320 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC90_11325 ENOG4105CW7 secretion protein, HlyD family FOC90_11330 ENOG4108JGH Tetr family transcriptional regulator FOC90_11335 ENOG4105CN9 Peptidase m42 family protein FOC90_11355 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC90_11360 ENOG4105C22 threonyL-tRNA synthetase FOC90_11365 ENOG4108TDW sporulation protein YtxC FOC90_11395 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC90_11400 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC90_11410 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC90_11415 ENOG4105C2M dna polymerase I FOC90_11420 ENOG4105BZU Histidine kinase FOC90_11425 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC90_11445 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC90_11450 ENOG4105BZN citrate synthase FOC90_11460 ENOG4108REF Sporulation integral membrane protein ytvi FOC90_11465 ENOG4105FS0 cytoplasmic membrane protein FOC90_11490 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC90_11495 ENOG4105C6K Malic enzyme FOC90_11500 ENOG4105C0B DNA polymerase III (alpha subunit) FOC90_11505 ENOG4105VV2 FOC90_11515 ENOG4105SFS phosphoesterase RecJ domain protein FOC90_11545 ENOG4105DC7 peptidase M24 FOC90_11580 ENOG4105Z7P Acetyltransferase (GNAT) family FOC90_11585 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC90_11605 ENOG4107YZX Universal stress protein FOC90_11645 ENOG4108JYZ YitT family FOC90_11665 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC90_11675 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC90_11680 ENOG4105KBJ sporulation protein ytfj FOC90_11695 ENOG4105EFZ amidohydrolase FOC90_11705 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC90_11730 ENOG4107RSM transcriptional regulator FOC90_11740 ENOG4105U5Y Transcriptional regulator FOC90_11750 ENOG4105C28 cystathionine FOC90_11775 ENOG4108UW5 maltose o-acetyltransferase FOC90_11785 ENOG4105F1V Acetoin utilization protein FOC90_11790 ENOG4105W87 Cbs domain FOC90_11795 ENOG4105DGU Histone deacetylase FOC90_11810 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC90_11815 ENOG4105BZU Histidine kinase FOC90_11820 ENOG4107SNB ankyrin repeat protein YahD FOC90_11825 ENOG4105EP9 oxidoreductase FOC90_11855 ENOG4105ETE Transcriptional regulator (LacI family FOC90_11865 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC90_11870 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC90_11890 ENOG4105C88 aminopeptidase FOC90_11910 ENOG4108IPJ Membrane FOC90_11935 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC90_11945 ENOG4108VDD TRNA binding domain protein FOC90_11975 ENOG4105C8F Beta-lactamase domain protein FOC90_11990 ENOG4108V15 phosphotransferase enzyme family FOC90_11995 ENOG4108IUM Glycogen debranching enzyme FOC90_12005 ENOG4107QSE Dipeptidase FOC90_12010 ENOG4105YW5 deoR family transcriptional regulator FOC90_12025 ENOG4105CBX hi0933 family FOC90_12060 ENOG4108VJ1 Transcriptional regulator (CarD family FOC90_12065 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC90_12070 ENOG4105CSC Glucose uptake protein FOC90_12085 ENOG4108ZAF Molybdopterin FOC90_12090 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC90_12095 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC90_12105 ENOG4105D06 uba thif-type nad fad binding protein FOC90_12110 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC90_12130 ENOG41085GJ domain protein FOC90_12140 ENOG4105DWV Homoserine O-trans-acetylase FOC90_12180 ENOG410605W Major Facilitator FOC90_12185 ENOG4107S91 Sodium hydrogen exchanger FOC90_12190 ENOG4105NCW Trka-c domain protein FOC90_12205 ENOG4105C19 ABC transporter FOC90_12225 ENOG4105N5T Radical SAM Protein FOC90_12250 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC90_12255 ENOG4108Z0R Transferase FOC90_12260 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC90_12265 ENOG4105BZF Glycosyl transferase (Group 1 FOC90_12275 ENOG4105EPU Molybdenum cofactor synthesis domain protein FOC90_12360 ENOG4105BZU Histidine kinase FOC90_12365 ENOG4105BZU Histidine kinase FOC90_12370 ENOG4105CH6 catalase FOC90_12375 ENOG4107S9D Alpha beta hydrolase FOC90_12380 ENOG4107T7U Sulfatase FOC90_12405 ENOG4105D2X ABC transporter substrate-binding protein FOC90_12415 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC90_12470 ENOG41080TC multidrug resistance protein FOC90_12475 ENOG410839T multidrug resistance protein FOC90_12495 ENOG4108V2W Carbonate dehydratase FOC90_12500 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC90_12505 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC90_12550 ENOG41087YS Phage shock protein A FOC90_12575 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FOC90_12580 ENOG4105BZU Histidine kinase FOC90_12585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_12610 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC90_12615 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC90_12665 ENOG4105BZU Histidine kinase FOC90_12675 ENOG4107ZTW SNARE associated Golgi FOC90_12690 ENOG4105C19 ABC transporter FOC90_12695 ENOG41086D8 Transcriptional regulator FOC90_12705 ENOG4105CJ1 ABC, transporter FOC90_12715 ENOG41082BM Transcriptional regulator, arsr family FOC90_12760 ENOG4105C6Z Gluconate FOC90_12785 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC90_12805 ENOG4105DTQ mandelate racemase muconate lactonizing FOC90_12815 ENOG4108IPT Naphthoate synthase FOC90_12820 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC90_12830 ENOG4105E4F Isochorismate synthase FOC90_12835 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC90_12845 ENOG4105VEQ Cold shock protein FOC90_12910 ENOG4108Q5F Tetr family transcriptional regulator FOC90_13045 ENOG4105KT7 mgtC SapB transporter FOC90_13050 ENOG4107PBV potassium channel FOC90_13065 ENOG4105WG9 Conserved Protein FOC90_13075 ENOG4105CHM Aminotransferase FOC90_13080 ENOG4108ZB6 transcriptional regulator AsnC family FOC90_13085 ENOG4105C5I Dehydrogenase FOC90_13090 ENOG4108MUZ hydrolase FOC90_13100 ENOG4105C87 Aminotransferase class I and II FOC90_13115 ENOG4105Y38 Kinase-associated protein B FOC90_13125 ENOG4107R3E Citrate transporter FOC90_13145 ENOG4105KA0 thioesterase Superfamily protein FOC90_13160 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC90_13180 ENOG41069ER domain protein FOC90_13195 ENOG4105CEP NADH dehydrogenase FOC90_13220 ENOG4105EWC Purine nucleoside phosphorylase FOC90_13250 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC90_13275 ENOG4108JJA ABC, transporter FOC90_13280 ENOG4105C4B ABC transporter, permease FOC90_13285 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC90_13335 ENOG41083MR nifu domain-containing protein FOC90_13350 ENOG4108W5N phosphatidylglycerophosphatase a FOC90_13370 ENOG4105DAX Pfam:DUF2983 FOC90_13380 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC90_13385 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC90_13400 ENOG4105CBT Fructose-1,6-bisphosphatase FOC90_13415 ENOG4105MMD transcriptional regulator FOC90_13420 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC90_13425 ENOG4107TXC Transcriptional regulator FOC90_13430 ENOG41090T1 Membrane FOC90_13455 ENOG4105FAA peptidase M23 FOC90_13460 ENOG4108YTE sporulation protein YunB FOC90_13465 ENOG4105KZD Domain of unknown function (DUF1805) FOC90_13470 ENOG4107R8B 5'-nucleotidase FOC90_13475 ENOG4105DIW FeS assembly protein SUFB FOC90_13480 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC90_13485 ENOG4105C9B Cysteine desulfurase FOC90_13490 ENOG4105JRK feS assembly protein SufD FOC90_13495 ENOG4105C3K feS assembly ATPase SufC FOC90_13500 ENOG4105D01 (LipO)protein FOC90_13505 ENOG4105D01 (LipO)protein FOC90_13510 ENOG4108UMI ABC transporter, permease FOC90_13515 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC90_13540 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC90_13560 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC90_13575 ENOG4108W8B Beta-lactamase domain protein FOC90_13580 ENOG4105C1G acyl-Coa dehydrogenase FOC90_13585 ENOG4105CHU acetyl-coa acetyltransferase FOC90_13600 ENOG4105DZ1 carboxypeptidase FOC90_13620 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC90_13635 ENOG4108SUT Major Facilitator Superfamily FOC90_13640 ENOG4107R7I amino acid FOC90_13655 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC90_13665 ENOG4107AYK membrAne FOC90_13700 ENOG4107ZTW SNARE associated Golgi FOC90_13710 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC90_13715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_13720 ENOG4105BZU Histidine kinase FOC90_13745 ENOG4105C8Q Methyl-accepting chemotaxis FOC90_13750 ENOG4105C8Q Methyl-accepting chemotaxis FOC90_13755 ENOG4105VG1 fes assembly suf system protein FOC90_13765 ENOG4105D4Y metalloprotease FOC90_13770 ENOG4105C2I pirin domain protein FOC90_13785 ENOG4107T5V SNARE associated Golgi FOC90_13790 ENOG4107S91 Sodium hydrogen exchanger FOC90_13795 ENOG4105NCW Trka-c domain protein FOC90_13805 ENOG4108RMU ferritin dps family protein FOC90_13820 ENOG4108URH decarboxylase FOC90_13830 ENOG41090A1 ferritin FOC90_13840 ENOG4105D9N nucleoside FOC90_13845 ENOG4105D9N nucleoside FOC90_13860 ENOG4108RYK Nad-dependent epimerase dehydratase FOC90_13875 ENOG4105CV8 reductase FOC90_13880 ENOG4105F27 Major Facilitator FOC90_13885 ENOG4105KVH Transcriptional regulator FOC90_13900 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC90_13905 ENOG4105D4A Cell wall formation (By similarity) FOC90_13915 ENOG4105C8Q Methyl-accepting chemotaxis FOC90_13930 ENOG4105WMR Protein CrcB homolog FOC90_13950 ENOG4105C5H ABC transporter FOC90_13955 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC90_13975 ENOG4108W2Y isochorismatase FOC90_13995 ENOG4108V2W Carbonate dehydratase FOC90_14000 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FOC90_14015 ENOG4108IPW abc transporter atp-binding protein FOC90_14020 ENOG4105CM4 permease protein FOC90_14035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_14050 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC90_14060 ENOG4105XZU Preprotein translocase, subunit SecG FOC90_14065 ENOG41067MG lrgb family FOC90_14115 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC90_14135 ENOG41090VF Stage v sporulation protein ac FOC90_14140 ENOG4105CZ3 stage V sporulation protein ad FOC90_14155 ENOG4108QY0 Membrane FOC90_14165 ENOG4105KRI phosphocarrier protein (HPr FOC90_14175 ENOG4105CHW UPF0052 protein FOC90_14185 ENOG4108Z4K mutator MutT protein FOC90_14195 ENOG4105C3M thioredoxin reductase FOC90_14205 ENOG4108S4C acetyltransferase FOC90_14225 ENOG41086DT Membrane protein of unknown function FOC90_14235 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC90_14255 ENOG4107TXC Transcriptional regulator FOC90_14270 ENOG4105HMI Membrane FOC90_14275 ENOG4105DUM transcriptional regulator, lysR family FOC90_14285 ENOG4108WS4 fmn reductase FOC90_14290 ENOG4105C5H ABC transporter FOC90_14300 ENOG4105BZ1 (ABC) transporter FOC90_14310 ENOG4105CN1 protease FOC90_14315 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC90_14320 ENOG4105CAK Cell division ATP-binding protein ftsE FOC90_14340 ENOG4105MS2 ribosomal subunit Interface protein FOC90_14345 ENOG4105VEQ Cold shock protein FOC90_14350 ENOG41081UC Inherit from COG: Competence protein FOC90_14365 ENOG4105KVH Transcriptional regulator FOC90_14375 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC90_14380 ENOG4108KGH TRANSCRIPTIONal FOC90_14385 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC90_14390 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC90_14395 ENOG4105ESV Glycosyl transferase, family 4 FOC90_14405 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC90_14425 ENOG4105F8D glycoside hydrolase family 4 FOC90_14430 ENOG4105VCP PTS System FOC90_14435 ENOG4105CK1 PTS System FOC90_14445 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC90_14450 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC90_14455 ENOG4105VCP PTS System FOC90_14465 ENOG4105VZJ PTS System FOC90_14485 ENOG4105ECB domain protein FOC90_14490 ENOG4107RSM transcriptional regulator FOC90_14525 ENOG4105DAA L-lactate FOC90_14535 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC90_14545 ENOG4105E0M Sulfatase FOC90_14570 ENOG4107R8N Glycosyl transferase, family 2 FOC90_14575 ENOG4105C94 Transporter FOC90_14580 ENOG41069ER domain protein FOC90_14605 ENOG4105KBK Zinc finger, swim domain protein FOC90_14610 ENOG4105C0D helicase FOC90_14640 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC90_14650 ENOG4107RBB ABC transporter, permease FOC90_14655 ENOG4105C19 ABC transporter FOC90_14675 ENOG4105CXY transporter FOC90_14690 ENOG4105BZU Histidine kinase FOC90_14695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_14710 ENOG4105CMR udp-glucose 4-epimerase FOC90_14715 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC90_14725 ENOG4105CPK Glycosyl transferase (Group 1 FOC90_14740 ENOG4105D3Q Sugar transferase FOC90_14745 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC90_14750 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC90_14755 ENOG4107YJ4 chain length determinant protein FOC90_14760 ENOG4105HTX biosynthesis protein FOC90_14765 ENOG4107YJ4 chain length determinant protein FOC90_14780 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC90_14790 ENOG4105FRN stage II sporulation protein FOC90_14805 ENOG4105DY9 regulatoR FOC90_14825 ENOG4106778 Protein of unknown function (DUF1146) FOC90_14830 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC90_14835 ENOG4105C8S subunit m FOC90_14840 ENOG4105D65 subunit l FOC90_14865 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC90_14870 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC90_14880 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC90_14885 ENOG4105BZU Histidine kinase FOC90_14935 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC90_14940 ENOG41062M3 atp synthase FOC90_14965 ENOG4108UIC UPF0340 protein FOC90_14970 ENOG4108YZG isomerase FOC90_14985 ENOG4108VGI doxx family FOC90_14990 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC90_15010 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC90_15020 ENOG4108ZXQ stage ii sporulation protein r FOC90_15025 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC90_15045 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC90_15050 ENOG4105CBT Fructose-1,6-bisphosphatase FOC90_15055 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC90_15090 ENOG4105C1G acyl-Coa dehydrogenase FOC90_15095 ENOG4105C1G acyl-Coa dehydrogenase FOC90_15100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC90_15110 ENOG4105DF6 Fe-S oxidoreductase FOC90_15115 ENOG41067QW Transcriptional regulator FOC90_15155 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC90_15160 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) FOC90_15215 ENOG4105BZU Histidine kinase FOC90_15230 ENOG4105D4Y metalloprotease FOC90_15240 ENOG4105BZU Histidine kinase FOC90_15245 ENOG4105KCT ABC transporter FOC90_15250 ENOG4108M15 ABC transporter FOC90_15255 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC90_15265 ENOG4105IIU Aminopeptidase FOC90_15285 ENOG4105EMN RNA polymerase sigma factor FOC90_15300 ENOG410684U Domain of unknown function (DUF1934) FOC90_15320 ENOG4105CYW agmatinase FOC90_15330 ENOG4105DXB Major Facilitator superfamily FOC90_15335 ENOG4107SWG transcriptional regulator MERR family FOC90_15340 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC90_15345 ENOG4105BZ4 penicillin-binding protein FOC90_15350 ENOG4108XFG YwhD family FOC90_15355 ENOG4108Z4T Peptidase M50 FOC90_15360 ENOG41069HH 4-oxalocrotonate tautomerase FOC90_15365 ENOG4105DCI Phosphohydrolase FOC90_15370 ENOG4108MES Periplasmic binding protein FOC90_15375 ENOG4105E0A ABC, transporter FOC90_15380 ENOG4105EHG Permease protein FOC90_15385 ENOG4105DQ5 transport system permease protein FOC90_15395 ENOG4108VCI transcription factor, rsfa family FOC90_15400 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FOC90_15405 ENOG4108IJ2 phosphate acetyltransferase FOC90_15420 ENOG4108VKI Cell wall hydrolase FOC90_15440 ENOG4107SVH Potassium channel protein FOC90_15450 ENOG410667J hydrolase FOC90_15455 ENOG4105VCH membrane FOC90_15465 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC90_15470 ENOG4105CJ1 ABC, transporter FOC90_15475 ENOG41090WU lipolytic protein G-D-S-L family FOC90_15490 ENOG4105D6E homoserine dehydrogenase FOC90_15510 ENOG4108Y4K DNA-binding transcriptional activator FOC90_15520 ENOG4105WH1 Two component transcriptional regulator luxr family FOC90_15525 ENOG4105BZU Histidine kinase FOC90_15530 ENOG4105DWF phosphomethylpyrimidine kinase FOC90_15535 ENOG4105BZU Histidine kinase FOC90_15540 ENOG4105VCD cytoplasmic protein FOC90_15545 ENOG4105D22 carbon starvation protein FOC90_15550 ENOG4105DY9 regulatoR FOC90_15555 ENOG41079KZ Major Facilitator Superfamily FOC90_15565 ENOG4105CG5 Glycosyl transferase (Group 1 FOC90_15575 ENOG4105EN6 Membrane FOC90_15580 ENOG4106YBV Methyl-accepting chemotaxis FOC90_15590 ENOG4108S4H thioesterase Superfamily protein FOC90_15595 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FOC90_15610 ENOG4105K64 Glycosyl transferase, family 2 FOC90_15620 ENOG4105EJV Membrane FOC90_15625 ENOG4105CKK Glycosyl transferase, family 2 FOC90_15635 ENOG4107XI7 Tetr family transcriptional regulator FOC90_15640 ENOG4105C5H ABC transporter FOC90_15645 ENOG41067SE Tetr family transcriptional regulator FOC90_15655 ENOG4105E0X reductase FOC90_15660 ENOG4106F5Q Membrane FOC90_15675 ENOG4108NEV two component transcriptional regulator, LytTR family FOC90_15680 ENOG4108HRK Histidine kinase FOC90_15685 ENOG4107RGD Major Facilitator superfamily FOC90_15700 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC90_15710 ENOG4105IW1 AmiS UreI transporter FOC90_15720 ENOG4105CMR udp-glucose 4-epimerase FOC90_15725 ENOG4108UT2 hemolysin iii FOC90_15735 ENOG4105C1J atp-dependent rna helicase FOC90_15740 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FOC90_15745 ENOG4105DPN Oligoendopeptidase f FOC90_15765 ENOG4107Y5K Resolvase FOC90_15815 ENOG4107Y5K Resolvase FOC90_15820 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC90_15865 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FOC90_15880 ENOG4105C0H protease FOC90_15885 ENOG4105Q2H domain protein FOC90_15900 ENOG4105BZU Histidine kinase FOC90_15905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_15930 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOC90_15935 ENOG4105CDU Replicative dna helicase FOC90_15945 ENOG4105BZR domain protein FOC90_15950 ENOG4108XMW Membrane FOC90_15960 ENOG4108UUM single-stranded DNA-binding protein FOC90_15970 ENOG4105C3G gtp-binding protein FOC90_15975 ENOG4105VDK protein, conserved in bacteria FOC90_15980 ENOG4105D8X mechanosensitive ion channel FOC90_15985 ENOG4108ZDA Sporulation protein YyaC FOC90_15990 ENOG4105FA0 parb-like partition protein FOC90_15995 ENOG4107QJE Chromosome Partitioning Protein FOC90_16015 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC90_16025 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC90_16045 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC90_16050 ENOG410848D S4 domain protein YaaA FOC90_16065 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC90_16100 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC90_16135 ENOG4105ZMH deoxynucleoside kinase FOC90_16145 ENOG4105GTG Isochorismatase FOC90_16150 ENOG4108Z6B deaminase FOC90_16160 ENOG4105C6E dna polymerase iii FOC90_16180 ENOG41067KS pro-sigma K processing FOC90_16215 ENOG4105CXN decarboxylase FOC90_16225 ENOG4105FA2 dna polymerase iii FOC90_16230 ENOG4105MA4 psp1 domain protein FOC90_16240 ENOG41060K3 Methyltransferase FOC90_16250 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC90_16255 ENOG4105KRN Transcriptional regulator, abrb family FOC90_16260 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC90_16265 ENOG4105F8V Hydrolase, tatD family FOC90_16270 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC90_16280 ENOG4105XFA sporulation peptidase YabG FOC90_16285 ENOG4105W42 Veg protein FOC90_16300 ENOG4105DFT pur operon repressor FOC90_16305 ENOG4105KME endoribonuclease L-psp FOC90_16325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC90_16335 ENOG4108JA2 transcriptioN-repair coupling factor FOC90_16340 ENOG4108M14 stage v sporulation protein t FOC90_16350 ENOG4108IY2 MazG family FOC90_16355 ENOG41082I2 s4 domain protein FOC90_16360 ENOG4105VYY sporulation protein yabp FOC90_16375 ENOG41060GV RNA binding s1 domain protein FOC90_16395 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC90_16400 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC90_16405 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC90_16420 ENOG4105C6T cysteine synthase FOC90_16425 ENOG4105CRQ synthase (Component I) FOC90_16430 ENOG4105DDQ anthranilate synthase FOC90_16435 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC90_16440 ENOG4105EEI dihydropteroate synthase FOC90_16445 ENOG4105KRF dihydroneopterin aldolase FOC90_16450 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC90_16460 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC90_16550 ENOG4108Z0C Uvrb UvrC protein FOC90_16565 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC90_16575 ENOG4105CTP PilT protein domain protein FOC90_16595 ENOG4105D7W serine acetyltransferase FOC90_16610 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC90_16615 ENOG4105M0M Tetracycline resistance protein FOC90_16620 ENOG4105QIV RNA polymerase FOC90_16635 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC90_16660 ENOG4107Y49 methyltransferase FOC90_16675 ENOG4105XPM ribosomal protein FOC90_16805 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC90_16815 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC90_16850 ENOG4108JJB ABC transporter FOC90_16855 ENOG4108JJB ABC transporter FOC90_16860 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC90_16865 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC90_16890 ENOG4105D1F ATP-binding protein FOC90_16905 ENOG4108NMV polysaccharide deacetylase FOC90_16985 ENOG4105C8B TIGR00159 family FOC90_16990 ENOG4107U5W ybbr family FOC90_17005 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC90_17025 ENOG4108PSK reductase FOC90_17030 ENOG4108UMI ABC transporter, permease FOC90_17035 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC90_17040 ENOG4105D01 (LipO)protein FOC90_17045 ENOG4105CB2 alcohol dehydrogenase FOC90_17055 ENOG4105IQ5 FAD linked oxidase domain protein FOC90_17070 ENOG4105C2C drug resistance transporter, Bcr CflA FOC90_17090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC90_17095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC90_17100 ENOG4105C3U ABC transporter FOC90_17105 ENOG4108JQ7 (ABC) transporter FOC90_17125 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC90_17150 ENOG4105E0C molybdate abc transporter FOC90_17155 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC90_17160 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC90_17190 ENOG4105F6E Acyl-transferase FOC90_17210 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC90_17225 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC90_17245 ENOG4105C5H ABC transporter FOC90_17255 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC90_17265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC90_17270 ENOG4105C3U ABC transporter FOC90_17275 ENOG4108JQ7 (ABC) transporter FOC90_17280 ENOG410667J hydrolase FOC90_17305 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC90_17310 ENOG4105ERH Fumarylacetoacetate hydrolase FOC90_17320 ENOG4105CUB amino acid FOC90_17325 ENOG4108SC4 )-transporter FOC90_17330 ENOG4105CPF Cell wall formation (By similarity) FOC90_17335 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC90_17360 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC90_17365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC90_17375 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC90_17480 ENOG4105K8N protein family UPF0079, ATPase FOC90_17485 ENOG41072GX Peptidase M22 Glycoprotease FOC90_17490 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC90_17495 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC90_17500 ENOG4105C5H ABC transporter FOC90_17515 ENOG4108TYN CAAX amino terminal protease family protein FOC90_17605 ENOG4108IBT Inherit from COG: transposase FOC90_17650 ENOG4106BHR ftsk SpoIIIE family protein FOC90_17660 ENOG4106128 DNA-binding helix-turn-helix protein FOC90_17675 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC90_17685 ENOG4105C7N Xanthine uracil vitamin C permease FOC90_17695 ENOG4105BZU Histidine kinase FOC90_17720 ENOG4107ZXU DSBA oxidoreductase FOC90_17740 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC90_17790 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC90_17810 ENOG410631K Membrane FOC90_17835 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC90_17840 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC90_17845 ENOG4105C83 adenylosuccinate lyase FOC90_17855 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC90_17880 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC90_17890 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC90_17915 ENOG4105C4R Atp-dependent dna helicase FOC90_17940 ENOG4108W2Y isochorismatase FOC90_17945 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC90_17950 ENOG4108UMI ABC transporter, permease FOC90_17955 ENOG4105D01 (LipO)protein FOC90_17975 ENOG410834F Transcriptional regulator FOC90_17980 ENOG4107I77 yiaA/B two helix domain FOC90_18000 ENOG4105CBD Diacylglycerol kinase FOC90_18005 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC90_18010 ENOG4108JPW Aminotransferase FOC90_18020 ENOG4105C26 Dehydrogenase FOC90_18025 ENOG4105KPY Small multidrug resistance protein FOC90_18050 ENOG4105D9N nucleoside FOC90_18055 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC90_18065 ENOG4108W15 Protein of unknown function (DUF1456) FOC90_18080 ENOG4105DTQ mandelate racemase muconate lactonizing FOC90_18090 ENOG4105DFD Na H antiporter FOC90_18110 ENOG4105D3R alkyl hydroperoxide reductase FOC90_18135 ENOG4105EHG Permease protein FOC90_18140 ENOG4105DQ5 transport system permease protein FOC90_18145 ENOG4108V5C ABC transporter FOC90_18165 ENOG4106UIA FOC90_18170 ENOG4106UIA FOC90_18185 ENOG4105BZU Histidine kinase FOC90_18205 ENOG410756H nucleotidyltransferase FOC90_18210 ENOG4105D2S major facilitator superfamily FOC90_18225 ENOG4105E5Q amino acid AbC transporter FOC90_18230 ENOG4105EAB amino acid AbC transporter FOC90_18235 ENOG4105CDA abc transporter atp-binding protein FOC90_18240 ENOG4105C8Q Methyl-accepting chemotaxis FOC90_18255 ENOG4105DBV ornithine carbamoyltransferase FOC90_18265 ENOG4105C5B carbamate kinase FOC90_18270 ENOG4108W63 CRP FNR family transcriptional regulator FOC90_18280 ENOG4105DNP FAD linked oxidase domain protein FOC90_18290 ENOG4105CI1 PTS System FOC90_18305 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC90_18320 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC90_18340 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC90_18345 ENOG4105D2X ABC transporter substrate-binding protein FOC90_18355 ENOG4105C5H ABC transporter FOC90_18385 ENOG41062JF Transcriptional regulator FOC90_18400 ENOG4105DEU major facilitator superfamily FOC90_18430 ENOG4108N0M stress protein FOC90_18435 ENOG4106FN3 tellurium resistance protein FOC90_18440 ENOG4106FN3 tellurium resistance protein FOC90_18445 ENOG4107TS3 membrane protein, TerC FOC90_18450 ENOG4108TTB tellurium resistance protein FOC90_18470 ENOG4105KJF protein tyrosine phosphatase FOC90_18480 ENOG4107U9T Pfam:Ribonuclease_BN FOC90_18485 ENOG4105C59 p-type ATPase FOC90_18490 ENOG4108IPJ Membrane FOC90_18500 ENOG4105C3F Signal peptidase i FOC90_18510 ENOG4107ZTW SNARE associated Golgi FOC90_18525 ENOG410606W general stress protein FOC90_18530 ENOG4105UPD Calcium Proton FOC90_18565 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC90_18575 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC90_18585 ENOG4108JUB Transcriptional regulator FOC90_18595 ENOG4108IQI permease FOC90_18635 ENOG4108A04 Beta-lactamase FOC90_18650 ENOG4105CKK Glycosyl transferase, family 2 FOC90_18655 ENOG4107QQG Dehydrogenase FOC90_18660 ENOG4105C3I Nad-dependent epimerase dehydratase FOC90_18665 ENOG4105CKK Glycosyl transferase, family 2 FOC90_18680 ENOG4105F1A Pyruvate formate-lyase FOC90_18700 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC90_18705 ENOG4105ECP epimerase FOC90_18735 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC90_18740 ENOG4105CEN a g-specific adenine glycosylase FOC90_18745 ENOG4106BXE FOC90_18765 ENOG4105BZ1 (ABC) transporter FOC90_18770 ENOG4107NBY Membrane FOC90_18775 ENOG4105CBC glutamate synthase FOC90_18785 ENOG4108IUW ABC transporter FOC90_18805 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC90_18810 ENOG4105G5W regulator Fur family FOC90_18930 ENOG4108JQC penicillin-binding protein 1A FOC90_18935 ENOG4108R9S DSBA oxidoreductase FOC90_18945 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC90_18955 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC90_18960 ENOG4105BZU Histidine kinase FOC90_18965 ENOG4105CYN Serine protein kinase FOC90_18980 ENOG4105C94 Transporter FOC90_18995 ENOG4105DZ6 Band 7 protein FOC90_19005 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC90_19010 ENOG4108V9W transcriptional regulatory protein FOC90_19015 ENOG4105D4T Citrate transporter FOC90_19040 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC90_19045 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC90_19050 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC90_19055 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC90_19060 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC90_19065 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC90_19070 ENOG4108STX response regulator FOC90_19075 ENOG4105US7 Histidine kinase FOC90_19100 ENOG4108MRH transcriptional regulatory protein FOC90_19110 ENOG4105C6K Malic enzyme FOC90_19120 ENOG4108UZ3 Transporter FOC90_19125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC90_19130 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC90_19140 ENOG4105BZU Histidine kinase FOC90_19145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_19160 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC90_19165 ENOG4108JB9 formate dehydrogenase FOC90_19185 ENOG4105CUB amino acid FOC90_19195 ENOG4105C59 p-type ATPase FOC90_19200 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC90_19235 ENOG41073R8 VanW family FOC90_19240 ENOG4108KGH TRANSCRIPTIONal FOC90_19245 ENOG4105D9N nucleoside FOC90_19250 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC90_19255 ENOG4105C37 (CBS) domain FOC90_19260 ENOG4108IJ0 Aspartate ammonia-lyase FOC90_19265 ENOG4105DAA L-lactate FOC90_19280 ENOG4105DUX Transporter FOC90_19285 ENOG4108MES Periplasmic binding protein FOC90_19290 ENOG4105DQ5 transport system permease protein FOC90_19295 ENOG4108IHU transport system permease protein FOC90_19300 ENOG4105E0A ABC, transporter FOC90_19315 ENOG4105EXW epimerase dehydratase FOC90_19325 ENOG4107T89 von Willebrand factor, type A FOC90_19330 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC90_19335 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC90_19345 ENOG4105BZU Histidine kinase FOC90_19350 ENOG4105D5Q Arginine ornithine antiporter FOC90_19355 ENOG4107414 GntR family transcriptional regulator FOC90_19360 ENOG4105C5Y PTS System FOC90_19365 ENOG4105CG3 alpha amylase, catalytic region FOC90_19380 ENOG4105E1K spore germination protein FOC90_19385 ENOG4105CRN Aminoglycoside phosphotransferase FOC90_19395 ENOG4105BZG amino acid carrier protein FOC90_19400 ENOG4105CDA abc transporter atp-binding protein FOC90_19405 ENOG4105CT1 (ABC) transporter FOC90_19410 ENOG4105EAD ABC transporter FOC90_19415 ENOG4105DRP amino acid AbC transporter FOC90_19420 ENOG4108IQI permease FOC90_19435 ENOG4105GFR rna polymerase sigma factor FOC90_19445 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC90_19450 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC90_19455 ENOG4105BZU Histidine kinase FOC90_19460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_19480 ENOG4105CHH sulfate transporter FOC90_19485 ENOG41068KF Universal stress protein FOC90_19495 ENOG4105CXY transporter FOC90_19500 ENOG41067TZ transcriptional regulator, MarR family FOC90_19505 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC90_19510 ENOG4105ETE Transcriptional regulator (LacI family FOC90_19515 ENOG4108RVA ribokinase FOC90_19525 ENOG4105C2J ABC transporter FOC90_19530 ENOG4105CNN ABC, transporter FOC90_19535 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC90_19580 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FOC90_19610 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC90_19615 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC90_19620 ENOG41069ER domain protein FOC90_19625 ENOG4105VZ8 Transcriptional regulator FOC90_19630 ENOG4107D63 FOC90_19645 ENOG4105DUX Transporter FOC90_19665 ENOG4105C85 amino acid FOC90_19670 ENOG4105C7N Xanthine uracil vitamin C permease FOC90_19685 ENOG4105MA6 gCN5-related N-acetyltransferase FOC90_19710 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC90_19715 ENOG4105E2S oxidase) subunit II FOC90_19735 ENOG4106CAD Protein of unknown function (DUF3311) FOC90_19740 ENOG4105E1V na solute symporter FOC90_19755 ENOG4108NHD germination protein FOC90_19765 ENOG4105CE1 Ferrous iron transport protein b FOC90_19770 ENOG4105CE1 Ferrous iron transport protein b FOC90_19775 ENOG4105CE1 Ferrous iron transport protein b FOC90_19780 ENOG4105CVA phosphate FOC90_19785 ENOG4105C8U phosphate abc transporter FOC90_19790 ENOG4105E2Z phosphate ABC transporter (Permease FOC90_19920 ENOG41080XQ Signal transduction protein with cbs domains FOC90_19940 ENOG4105ETU transcriptional activator (TenA FOC90_19950 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC90_19960 ENOG4108VEU Thiamine monophosphate synthase FOC90_19965 ENOG41080HI glycine oxidase FOC90_19980 ENOG4105D06 uba thif-type nad fad binding protein FOC90_19985 ENOG4105DWF phosphomethylpyrimidine kinase FOC90_20035 ENOG4108INS Transcriptional regulator FOC90_20050 ENOG4105C7N Xanthine uracil vitamin C permease FOC90_20060 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC90_20075 ENOG4105K63 Thioredoxin FOC90_20095 ENOG4108B31 Spore germination protein FOC90_20115 ENOG4107Y03 Nitroreductase FOC90_20120 ENOG4105ED1 spovr family FOC90_20140 ENOG4105XTG Pfam:DUF156 FOC90_20145 ENOG4105VFE sira family FOC90_20150 ENOG4107TPS domain protein FOC90_20155 ENOG4105VFE sira family FOC90_20160 ENOG4105VFE sira family FOC90_20170 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC90_20175 ENOG41087NI Sulfite exporter TauE/SafE FOC90_20185 ENOG4108KGH TRANSCRIPTIONal FOC90_20210 ENOG4105EMD TRANSCRIPTIONal FOC90_20215 ENOG4105VCP PTS System FOC90_20220 ENOG4105VZJ PTS System FOC90_20245 ENOG41069ER domain protein FOC90_20250 ENOG4107RBB ABC transporter, permease FOC90_20255 ENOG4105C19 ABC transporter FOC90_20285 ENOG4105WEF catalase FOC90_20320 ENOG4107T5V SNARE associated Golgi FOC90_20355 ENOG4105CUB amino acid FOC90_20360 ENOG4107RWR Sodium hydrogen exchanger FOC90_20370 ENOG4106KNT transcriptional regulator FOC90_20410 ENOG4108YXU transcriptional regulator AsnC family FOC90_20420 ENOG4105UBK short-chain dehydrogenase reductase FOC90_20425 ENOG4105W1Y Transcriptional regulator FOC90_20470 ENOG4107RKG DJ-1/PfpI family FOC90_20475 ENOG4105CH6 catalase FOC90_20485 ENOG4105D5Q Arginine ornithine antiporter FOC90_20490 ENOG4105C26 Dehydrogenase FOC90_20495 ENOG4105BZ1 (ABC) transporter FOC90_20500 ENOG4105BZ1 (ABC) transporter FOC90_20510 ENOG4105DRP amino acid AbC transporter FOC90_20515 ENOG4105CDA abc transporter atp-binding protein FOC90_20530 ENOG410839P FOC90_20565 ENOG4107FQX Alpha-acetolactate decarboxylase FOC90_20590 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC90_20595 ENOG4105D4P Coproporphyrinogen iii oxidase FOC90_20600 ENOG4105CEY Amp-dependent synthetase and ligase FOC90_20610 ENOG4105CHH sulfate transporter FOC90_20635 ENOG4105CGU Enoyl-CoA hydratase FOC90_20655 ENOG4105DER m42 family FOC90_20680 ENOG4105CIF Ornithine Cyclodeaminase FOC90_20695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC90_20705 ENOG4108JQ7 (ABC) transporter FOC90_20735 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FOC90_20750 ENOG4105D06 uba thif-type nad fad binding protein FOC90_20755 ENOG4107SFI Major Facilitator superfamily FOC90_20815 ENOG4105GMB type VI secretion system effector, hcp1 family FOC90_20870 ENOG4105CSH Transporter FOC90_20880 ENOG4108MRH transcriptional regulatory protein FOC90_20925 ENOG4105C4R Atp-dependent dna helicase FOC90_20945 ENOG4105CDU Replicative dna helicase FOC90_20975 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC90_21060 ENOG4105F6J Alpha beta hydrolase fold FOC90_21120 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC90_21130 ENOG4105F27 Major Facilitator FOC90_21135 ENOG4105WAB arsR family transcriptional regulator FOC90_21145 ENOG4105CMT Dihydroxyacetone kinase FOC90_21155 ENOG4105CMT Dihydroxyacetone kinase FOC90_21280 ENOG4105WN5 stage II sporulation protein FOC90_21290 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC90_21300 ENOG4108MJI response regulator FOC90_21305 ENOG4105BZU Histidine kinase FOC90_21310 ENOG4105BZU Histidine kinase FOC90_21350 ENOG4105D7V transposase FOC90_21360 ENOG4107QHE Choloylglycine hydrolase FOC90_21380 ENOG4107VRP DNA repair exonuclease FOC90_21385 ENOG4106D4I domain protein FOC90_21400 ENOG410829K Lysine exporter protein (Lyse ygga) FOC90_21425 ENOG4108MUZ hydrolase FOC90_21450 ENOG4105F0F Oxalate decarboxylase FOC90_21455 ENOG41067QW Transcriptional regulator FOC90_21460 ENOG4105D7V transposase FOC90_21465 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC90_21480 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC90_21515 ENOG4105EEM helicase FOC90_21520 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC90_21545 ENOG4105K59 histidine triad (HIT) protein FOC90_21580 ENOG410905X membrane-flanked domain protein FOC90_21585 ENOG4105CKV Membrane FOC90_21625 ENOG410905X membrane-flanked domain protein FOC90_21635 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC90_21640 ENOG4105BZ4 penicillin-binding protein FOC90_21650 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC90_21655 ENOG4105C1Q protoporphyrinogen oxidase FOC90_21685 ENOG4105ECB domain protein FOC90_21715 ENOG4106AXD FOC90_21720 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC90_21725 ENOG4105DF9 Lipoate-protein, ligase FOC90_21735 ENOG4105CEY Amp-dependent synthetase and ligase FOC90_21795 ENOG4105ENX hydrolase FOC90_21800 ENOG4107RN3 metallophosphoesterase FOC90_21805 ENOG4107TVP HD domain protein FOC90_21815 ENOG4108AEY RNA polymerase sigma factor FOC90_21820 ENOG41086D8 Transcriptional regulator FOC90_21835 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC90_21855 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC90_21860 ENOG4105C8Q Methyl-accepting chemotaxis FOC90_21870 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FOC90_21880 ENOG4107QP3 malate synthase g FOC90_21915 ENOG4105XVF Competence transcription factor FOC90_21980 ENOG4105ERH Fumarylacetoacetate hydrolase FOC90_21990 ENOG4105C8Y Acetylornithine aminotransferase FOC90_22005 ENOG4105CAQ asparagine synthetase FOC90_22010 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC90_22015 ENOG4105CH6 catalase FOC90_22020 ENOG4105BZU Histidine kinase FOC90_22040 ENOG4105QNR S1 RNA binding domain protein FOC90_22045 ENOG4105CNA YD repeat protein FOC90_22090 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC90_22100 ENOG4107AYK membrAne FOC90_22105 ENOG41073B9 FOC90_22115 ENOG4108KP7 hydrolase FOC90_22125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC90_22150 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC90_22155 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC90_22170 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC90_22185 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC90_22190 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC90_22200 ENOG4108JQ7 (ABC) transporter FOC90_22205 ENOG4105UQX Mate efflux family protein FOC90_22225 ENOG4108ZCF integral membrane protein FOC90_22235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC90_22245 ENOG4105DPN Oligoendopeptidase f FOC90_22260 ENOG4108Z18 K06886 hemoglobin FOC90_22265 ENOG4105MIX Adenylate cyclase FOC90_22280 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC90_22285 ENOG4105EMS pseudouridine synthase FOC90_22305 ENOG4105K64 Glycosyl transferase, family 2 FOC90_22345 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC90_22350 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC90_22360 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC90_22435 ENOG4105CK7 Sodium proline symporter FOC90_22445 ENOG4105DDQ anthranilate synthase FOC90_22540 ENOG4105C7S Dehydrogenase FOC90_22550 ENOG4105VZ8 Transcriptional regulator FOC90_22580 ENOG4108IUX (ABC) transporter FOC90_22585 ENOG4105RHA ABC transporter, permease FOC90_22610 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC90_22620 ENOG4105DZ1 carboxypeptidase FOC90_22625 ENOG4105VFR signal peptidase FOC90_22660 ENOG4105C26 Dehydrogenase FOC90_22665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC90_22670 ENOG4105F38 ABC transporter, permease FOC90_22675 ENOG4105D38 putrescine abc transporter FOC90_22680 ENOG4108HM4 ABC transporter FOC90_22685 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC90_22690 ENOG4105EYF MMPL domain protein FOC90_22700 ENOG4108YBP pseudouridine synthase FOC90_22710 ENOG4105K4I Scp-like extracellular FOC90_22715 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC90_22720 ENOG4105CQB FAD linked oxidase domain protein FOC90_22735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_22740 ENOG4105BZU Histidine kinase FOC90_22745 ENOG4105JXH GntR family transcriptional regulator FOC90_22765 ENOG4106A3R peptidase FOC90_22775 ENOG4108QTI )-transporter FOC90_22780 ENOG4107TS3 membrane protein, TerC FOC90_22785 ENOG4105CZN Potassium uptake protein FOC90_22790 ENOG410681C small acid-soluble spore protein FOC90_22795 ENOG4108Z7G MaoC domain protein dehydratase FOC90_22815 ENOG4105CHR reductase FOC90_22845 ENOG4105C4Y ABC transporter FOC90_22850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC90_22855 ENOG4107RCV ABC transporter, permease FOC90_22875 ENOG4105E98 transcriptional regulator DeoR family FOC90_22885 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC90_22895 ENOG4105PXI polysaccharide deacetylase FOC90_22905 ENOG4105BZU Histidine kinase FOC90_22910 ENOG41090MY MarR family Transcriptional regulator FOC90_22920 ENOG4106DF1 FOC90_22925 ENOG4105BZU Histidine kinase FOC90_22935 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC90_22940 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC90_22980 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC90_22985 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC90_22990 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC90_22995 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC90_23000 ENOG4105CZV ABC transporter FOC90_23010 ENOG4105CJ1 ABC, transporter FOC90_23050 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC90_23055 ENOG4105EA8 2-Nitropropane dioxygenase FOC90_23060 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC90_23070 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC90_23095 ENOG4105NQC Flavodoxin FOC90_23135 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC90_23165 ENOG4105CZN Potassium uptake protein FOC90_23170 ENOG41063Y9 FOC90_23175 ENOG4105KBJ sporulation protein ytfj FOC90_23195 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC90_23200 ENOG4105C7K acetolactate synthase FOC90_23205 ENOG4108ZP8 Acetolactate synthase small subunit FOC90_23210 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC90_23245 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC90_23280 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC90_23295 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC90_23300 ENOG4105E0M Sulfatase FOC90_23310 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC90_23330 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC90_23335 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC90_23345 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC90_23350 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC90_23355 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC90_23360 ENOG4105C8J )-transporter FOC90_23385 ENOG4105DFD Na H antiporter FOC90_23405 ENOG4105ENE Histidine kinase FOC90_23410 ENOG4105WH1 Two component transcriptional regulator luxr family FOC90_23430 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC90_23455 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC90_23475 ENOG4105CJ3 phosphate transporter FOC90_23480 ENOG4107GRR phosphate transport regulator FOC90_23485 ENOG4105BZ4 penicillin-binding protein FOC90_23500 ENOG4105BZU Histidine kinase FOC90_23505 ENOG4105I3N Conserved Protein FOC90_23520 ENOG4105BZU Histidine kinase FOC90_23550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC90_23555 ENOG4105DZ1 carboxypeptidase FOC90_23560 ENOG4108JIC nucleoside recognition domain protein FOC90_23570 ENOG4105FE9 pseudouridine synthase FOC90_23575 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC90_23580 ENOG4107TWT Cytochrome c biogenesis protein FOC90_23585 ENOG4105CRE cytochrome C FOC90_23590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_23595 ENOG4105BZU Histidine kinase FOC90_23600 ENOG4108WBT adenosyltransferase FOC90_23605 ENOG41063SB peptidase FOC90_23615 ENOG4108SAX Membrane FOC90_23630 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC90_23635 ENOG4105I7S Abortive infection protein FOC90_23645 ENOG4107RGJ metallophosphoesterase FOC90_23650 ENOG4108XDN Transcriptional regulator FOC90_23655 ENOG4108S6Z Negative regulator of genetic competence FOC90_23680 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC90_23685 ENOG4107RB3 L-asparaginase FOC90_23720 ENOG4105S2F FOC90_23725 ENOG41065D1 FOC90_23755 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC90_23770 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC90_23780 ENOG4105EAH synthase FOC90_23785 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOC90_23790 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC90_23805 ENOG41068YB TPR repeat-containing protein FOC90_23820 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC90_23825 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC90_23860 ENOG4108JYZ YitT family FOC90_23865 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC90_23880 ENOG4105FJR Lmbe family FOC90_23885 ENOG4105CPK Glycosyl transferase (Group 1 FOC90_23920 ENOG4105DVT helicase FOC90_23925 ENOG4105YAC FOC90_23945 ENOG4105CSM endonuclease III FOC90_23955 ENOG4105BZ4 penicillin-binding protein FOC90_24010 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC90_24020 ENOG4105DVT helicase FOC90_24025 ENOG4105CTD carboxy-peptidase FOC90_24040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC90_24050 ENOG4105C2W permease FOC90_24055 ENOG4105DHF Membrane FOC90_24065 ENOG410890F Dynamin family FOC90_24075 ENOG4108W0I acetyltransferase FOC90_24085 ENOG4105KHC sulfurtransferase FOC90_24110 ENOG4106032 Glutathionylspermidine synthase FOC90_24140 ENOG4105HTX biosynthesis protein FOC90_24170 ENOG4105CPK Glycosyl transferase (Group 1 FOC90_24185 ENOG4108SZE gCN5-related N-acetyltransferase FOC90_24205 ENOG41081VK Ribonuclease FOC90_24270 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC90_24280 ENOG4107RWR Sodium hydrogen exchanger FOC90_24290 ENOG4108Z5V transcriptional regulator, merr family FOC90_24300 ENOG4105H67 Protein of unknown function (DUF421) FOC90_24305 ENOG41080C8 DUF218 domain FOC90_24345 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC90_24355 ENOG4107R0U MotA TolQ exbB proton channel FOC90_24360 ENOG4105ER2 Ompa motb domain protein FOC90_24365 ENOG4107YTP response regulator receiver protein FOC90_24370 ENOG4105CBS Chea signal transduction histidine kinase FOC90_24375 ENOG4105DD5 Flagellar motor switch protein FOC90_24390 ENOG4105BZU Histidine kinase FOC90_24410 ENOG4105E1Q flagellar hook-associated protein FOC90_24415 ENOG4105DTJ flagellar hook-associated protein FOC90_24435 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC90_24440 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC90_24450 ENOG4107U2N Flagellar M-ring protein FOC90_24455 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC90_24485 ENOG4105BZE flagellar hook protein, FlgE FOC90_24500 ENOG4107R88 Chemotaxis protein (CheV) FOC90_24520 ENOG4105I03 Flagellin FOC90_24525 ENOG4105E4C Lytic transglycosylase catalytic FOC90_24535 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC90_24540 ENOG4105DD5 Flagellar motor switch protein FOC90_24550 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC90_24555 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC90_24565 ENOG4105D00 flagellar biosynthetic protein flhB FOC90_24570 ENOG4105D7B Flagellar biosynthesis protein flha FOC90_24575 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC90_24580 ENOG4105KTQ flagellar basal-body rod protein FOC90_24590 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC90_24620 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC90_24625 ENOG4107QZ7 Cellulose synthase catalytic subunit FOC90_24665 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC90_24670 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC90_24705 ENOG4105CVJ phosphoglycerate mutase FOC90_24715 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FOC90_24725 ENOG4105K56 Transcriptional regulator FOC90_24735 ENOG4105CAQ asparagine synthetase FOC90_24755 ENOG4105PGM cation diffusion facilitator family transporter FOC90_24775 ENOG4105CKI cobalamin synthesis protein FOC90_24780 ENOG4108PJD permease FOC90_24795 ENOG4105DFD Na H antiporter FOC90_24800 ENOG4105VUF Transcriptional regulator FOC90_24810 ENOG4105C9Q fumarate hydratase class II FOC90_24830 ENOG4107QJQ Mate efflux family protein FOC90_24835 ENOG4105EC3 peptidase S51, dipeptidase E FOC90_24855 ENOG4107QIV Cytochrome c biogenesis protein FOC90_24860 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC90_24875 ENOG4107JM4 Tetratricopeptide repeat FOC90_24895 ENOG4106BRA Membrane FOC90_24930 ENOG4105CJ1 ABC, transporter FOC90_24950 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC90_24960 ENOG4108IJ0 Aspartate ammonia-lyase FOC90_24965 ENOG4105C6K Malic enzyme FOC90_25015 ENOG4105FVX FOC90_25020 ENOG4105E09 nadh pyrophosphatase FOC90_25035 ENOG4105CSR polyphosphate kinase 2 FOC90_25040 ENOG4105U3E Transcriptional regulator FOC90_25050 ENOG4105DXI Major Facilitator superfamily FOC90_25060 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC90_25065 ENOG4105EU0 Major facilitator Superfamily FOC90_25070 ENOG4105C6T cysteine synthase FOC90_25090 ENOG4105C8J )-transporter FOC90_25100 ENOG4105X5K response regulator receiver protein FOC90_25105 ENOG4105H67 Protein of unknown function (DUF421) FOC90_25125 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC90_25130 ENOG4105CHR reductase FOC90_25135 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC90_25140 ENOG4105C7K acetolactate synthase FOC90_25150 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC90_25160 ENOG4105C7B Threonine dehydratase FOC90_25185 ENOG4105C6X Major Facilitator FOC90_25190 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC90_25205 ENOG4105DY9 regulatoR FOC90_25210 ENOG4105CYC Transferase FOC90_25235 ENOG41068WN FOC90_25255 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC90_25270 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC90_25275 ENOG4105C0X amino acid FOC90_25310 ENOG410849A acetyltransferase, (GNAT) family FOC90_25315 ENOG4105K8R UPF0145 protein FOC90_25330 ENOG4107RHR regulatoR FOC90_25340 ENOG4105D9N nucleoside FOC90_25345 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC90_25350 ENOG4105KG3 cytidine deaminase FOC90_25395 ENOG4107RAQ aminopeptidase FOC90_25405 ENOG4107R16 Multicopper oxidase FOC90_25445 ENOG4108T5E Copper resistance protein FOC90_25450 ENOG4105KTB nuclear export factor GLE1 FOC90_25455 ENOG4107RT3 EamA-like transporter family FOC90_25460 ENOG4105GZI Transcriptional regulator FOC90_25465 ENOG4108Z40 Transcriptional regulator FOC90_25470 ENOG4107ZXU DSBA oxidoreductase FOC90_25475 ENOG4108TVJ Nitroreductase FOC90_25480 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC90_25485 ENOG4106F5Q Membrane FOC90_25490 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC90_25500 ENOG4105CKI cobalamin synthesis protein FOC90_25510 ENOG4105C0Z ABC transporter FOC90_25515 ENOG4108IV0 ABC, transporter FOC90_25520 ENOG4105C32 Amino acid ABC transporter (Permease) FOC90_25530 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family FOC90_25560 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC90_25565 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC90_25570 ENOG4108JJ9 ABC, transporter FOC90_25575 ENOG4108JJ8 (ABC) transporter FOC90_25585 ENOG4105K64 Glycosyl transferase, family 2 FOC90_25595 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC90_25650 ENOG4105BZ1 (ABC) transporter FOC90_25655 ENOG4105EFI regulatoR FOC90_25660 ENOG4105BZU Histidine kinase FOC90_25680 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC90_25705 ENOG4105D6E homoserine dehydrogenase FOC90_25730 ENOG4108KGH TRANSCRIPTIONal FOC90_25745 ENOG4105KT7 mgtC SapB transporter FOC90_25750 ENOG4105VRR gCN5-related N-acetyltransferase FOC90_25760 ENOG4105DUU IucA IucC family protein FOC90_25765 ENOG4105CEY Amp-dependent synthetase and ligase FOC90_25780 ENOG4108WBH protein TIM barrel FOC90_25785 ENOG4105YWU small acid-soluble spore protein FOC90_25795 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC90_25800 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC90_25850 ENOG4105KRN Transcriptional regulator, abrb family FOC90_25860 ENOG4105YVS arsR family transcriptional regulator FOC90_25865 ENOG4105CPC Aldo Keto reductase FOC90_25895 ENOG4105C8Q Methyl-accepting chemotaxis FOC90_25910 ENOG4108K88 Membrane FOC90_25915 ENOG4108WPJ Ferritin-like domain FOC90_25930 ENOG4105DEN Luciferase family FOC90_25945 ENOG4105VMI -acetyltransferase FOC90_25950 ENOG4107QM2 Aldo Keto reductase FOC90_25955 ENOG4105CKI cobalamin synthesis protein FOC90_25965 ENOG4105DSE periplasmic solute binding protein FOC90_25975 ENOG4105K4T epimerase FOC90_25985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC90_26010 ENOG4105CVJ phosphoglycerate mutase FOC90_26030 ENOG4107T5V SNARE associated Golgi FOC90_26045 ENOG4108PJD permease FOC90_26055 ENOG4108S4H thioesterase Superfamily protein FOC90_26065 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC90_26085 ENOG4105SXS Protein of unknown function (DUF456) FOC90_26090 ENOG4105C37 (CBS) domain FOC90_26120 ENOG4108Z7R Chaperone CsaA FOC90_26140 ENOG4108ZRV stage ii sporulation protein p FOC90_26150 ENOG4108VXD carboxy-peptidase FOC90_26180 ENOG4108ZRV stage ii sporulation protein p FOC90_26190 ENOG4108X4Q Hydrolase FOC90_26195 ENOG41082F9 transcriptional regulator FOC90_26200 ENOG4105D94 Major Facilitator Superfamily FOC90_26210 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC90_26230 ENOG41087PP glycosyltransferase MGT family FOC90_26235 ENOG4108JYZ YitT family FOC90_26240 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC90_26270 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC90_26425 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC90_26435 ENOG4105KBJ sporulation protein ytfj FOC90_26460 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC90_26480 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FOC90_26485 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC90_26495 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC90_26500 ENOG4105EMN RNA polymerase sigma factor FOC90_26510 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOC90_26520 ENOG4105CNW domain protein FOC90_26530 ENOG4108V06 Glutathione peroxidase FOC90_26545 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC90_26555 ENOG4108IUE nitrate reductase beta subunit FOC90_26560 ENOG4105R3A Nitrate reductase FOC90_26570 ENOG4107V6Q Cyclic nucleotide-binding domain FOC90_26575 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC90_26580 ENOG4105D06 uba thif-type nad fad binding protein FOC90_26585 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC90_26590 ENOG4108ZAF Molybdopterin FOC90_26615 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC90_26620 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC90_26625 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC90_26630 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC90_26635 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC90_26640 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC90_26675 ENOG4105MCT stage V sporulation protein S FOC90_26715 ENOG4105C5H ABC transporter FOC90_26730 ENOG4108UUM single-stranded DNA-binding protein FOC90_26755 ENOG4107YX5 Pfam:DUF548 FOC90_26760 ENOG4105C75 arginyL-tRNA synthetase FOC90_26785 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC90_26800 ENOG4105C5S asparaginyl-tRNA synthetase FOC90_26805 ENOG4105C8J )-transporter FOC90_26810 ENOG4108EF6 Proline imino-peptidase FOC90_26825 ENOG4107XGZ Hydrolase FOC90_26830 ENOG4105CY2 Citrate transporter FOC90_26850 ENOG4105KD7 acetyltransferase FOC90_26860 ENOG4105VMP Transcriptional regulator FOC90_26865 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC90_26890 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC90_26920 ENOG4107RVG penicillin-binding protein FOC90_26930 ENOG4105E9Q Acyl-transferase FOC90_26935 ENOG4108UT2 hemolysin iii FOC90_26945 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC90_26955 ENOG4108RCR degv family FOC90_26965 ENOG4108KF3 Electron transport protein SCO1 SenC FOC90_26970 ENOG4107Y70 Heat shock protein FOC90_26975 ENOG4105CAQ asparagine synthetase FOC90_26990 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC90_26995 ENOG4108MES Periplasmic binding protein FOC90_27000 ENOG4105F0I Aminotransferase FOC90_27025 ENOG4105D8X mechanosensitive ion channel FOC90_27030 ENOG4105BZU Histidine kinase FOC90_27035 ENOG4105WH1 Two component transcriptional regulator luxr family FOC90_27040 ENOG4106KNT transcriptional regulator FOC90_27045 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC90_27065 ENOG4105CMG Carbohydrate kinase FOC90_27070 ENOG4105C6Z Gluconate FOC90_27080 ENOG4108YV3 Protein of unknown function (DUF2711) FOC90_27110 ENOG4108IJ8 ABC transporter FOC90_27115 ENOG4105E90 ABC transporter FOC90_27150 ENOG4105C37 (CBS) domain FOC90_27175 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC90_27190 ENOG4107S4Y M20 DapE family protein YgeY FOC90_27195 ENOG4108TSC N-acetyltransferase FOC90_27200 ENOG4108JUB Transcriptional regulator FOC90_27205 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC90_27250 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC90_27260 ENOG4105SZ6 Thioredoxin FOC90_27300 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC90_27355 ENOG4105BZ4 penicillin-binding protein FOC90_27365 ENOG4105CZM Major Facilitator FOC90_27370 ENOG4105W8X HesB YadR YfhF-family protein FOC90_27380 ENOG4105DXD 2-methylcitrate dehydratase FOC90_27385 ENOG4105CR4 methylisocitrate lyase FOC90_27390 ENOG4105C1G acyl-Coa dehydrogenase FOC90_27395 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC90_27405 ENOG4105N14 lysine exporter protein LysE YggA FOC90_27410 ENOG4105E39 Enoyl-CoA hydratase FOC90_27425 ENOG4107RFY SbcCD D subunit FOC90_27430 ENOG4105EYH Exonuclease FOC90_27450 ENOG4105FCD Major Facilitator FOC90_27455 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC90_27460 ENOG4105E4F Isochorismate synthase FOC90_27465 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC90_27470 ENOG4105WQI isochorismatase FOC90_27475 ENOG4105CEY Amp-dependent synthetase and ligase FOC90_27480 ENOG4105WQT MbtH domain protein FOC90_27485 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC90_27500 ENOG4105K70 DNA-binding protein FOC90_27520 ENOG4105BZG amino acid carrier protein FOC90_27540 ENOG4105FE9 pseudouridine synthase FOC90_27545 ENOG4105C22 threonyL-tRNA synthetase FOC90_27550 ENOG4105C19 ABC transporter FOC90_27585 ENOG41081I9 integral membrane protein FOC90_27595 ENOG4108Y4K DNA-binding transcriptional activator FOC90_27615 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC90_27625 ENOG4105EYF MMPL domain protein FOC90_27650 ENOG4105WCN acetyltransferase FOC90_27675 ENOG4105C1Q protoporphyrinogen oxidase FOC90_27685 ENOG41068WN FOC90_27715 ENOG4107V2S Transcriptional regulator FOC90_27720 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC90_27735 ENOG4105DND Transcriptional regulator FOC90_27740 ENOG4108RPX mosc domain containing protein FOC90_27755 ENOG4105BZ1 (ABC) transporter FOC90_27760 ENOG4105BZ1 (ABC) transporter FOC90_27785 ENOG4108JCI Transcriptional regulator FOC90_27815 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FOC90_27820 ENOG4108KPJ rna polymerase sigma factor FOC90_27845 ENOG4105F32 YngK protein FOC90_27870 ENOG4105RD7 BadF BadG BcrA BcrD FOC90_27875 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC90_27880 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC90_27890 ENOG4108INS Transcriptional regulator FOC90_27905 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC90_27915 ENOG4105C1J atp-dependent rna helicase FOC90_27920 ENOG41088CC tellurite resistance protein tehB FOC90_27930 ENOG4108I0C methyltransferase FOC90_27975 ENOG4105CIN aminoacyl-histidine dipeptidase FOC90_28000 ENOG4105KRN Transcriptional regulator, abrb family FOC90_28010 ENOG4105EJ9 Membrane FOC90_28055 ENOG4105W8Z 4'-phosphopantetheinyl transferase FOC90_28065 ENOG4105CHR reductase FOC90_28125 ENOG4108W0I acetyltransferase FOC90_28130 ENOG4107QQG Dehydrogenase FOC90_28135 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOC90_28140 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC90_28145 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOC90_28160 ENOG4105FJR Lmbe family FOC90_28170 ENOG4105IIU Aminopeptidase FOC90_28175 ENOG4108SC4 )-transporter FOC90_28215 ENOG4108IMY Transcriptional regulator FOC90_28265 ENOG4107RVG penicillin-binding protein FOC90_28280 ENOG4107RF6 penicillin-binding protein FOC90_28290 ENOG4107RF6 penicillin-binding protein FOC90_28300 ENOG4105DIN metallophosphoesterase FOC90_28320 ENOG4107Z3H Transcriptional regulator, TetR family FOC90_28335 ENOG4105C1G acyl-Coa dehydrogenase FOC90_28340 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC90_28345 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC90_28350 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC90_28355 ENOG4105E39 Enoyl-CoA hydratase FOC90_28360 ENOG4107QX3 carboxylase FOC90_28365 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC90_28400 ENOG4105DZ1 carboxypeptidase FOC90_28415 ENOG4105T9C HD domain FOC90_28430 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC90_28450 ENOG41075H3 AraC family transcriptional regulator FOC90_28480 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC90_28490 ENOG4105CHR reductase FOC90_28495 ENOG4105KVH Transcriptional regulator FOC90_28565 ENOG410900G Protein of unknown function (DUF421) FOC90_28575 ENOG4108V4B ThiJ pfpI FOC90_28585 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC90_28595 ENOG4105DK7 lysyl-tRNA synthetase FOC90_28620 ENOG4106NZI LysR family Transcriptional regulator FOC90_28625 ENOG4105CPC Aldo Keto reductase FOC90_28670 ENOG4105D6E homoserine dehydrogenase FOC90_28680 ENOG4105CPF Cell wall formation (By similarity) FOC90_28685 ENOG4105ETU transcriptional activator (TenA FOC90_28780 ENOG410667J hydrolase FOC90_28785 ENOG4105BZU Histidine kinase FOC90_28790 ENOG4107RF6 penicillin-binding protein FOC90_28815 ENOG4108FPN Integrase FOC90_28855 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FOC90_28865 ENOG4108VJ1 Transcriptional regulator (CarD family FOC90_28925 ENOG4105KVH Transcriptional regulator FOC90_28935 ENOG4105C4W S-formylglutathione hydrolase FOC90_28945 ENOG4105D9M gamma-glutamylcysteine synthetase FOC90_28955 ENOG41082BM Transcriptional regulator, arsr family FOC90_28980 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC90_28985 ENOG4108606 TspO/MBR family FOC90_29000 ENOG4105WG9 Conserved Protein FOC90_29015 ENOG4105ECP epimerase FOC90_29025 ENOG4105XZV Protein of unknown function (DUF3243) FOC90_29035 ENOG4105F6S Spore photoproduct lyase FOC90_29060 ENOG4108JJB ABC transporter FOC90_29075 ENOG4108HGU Histidine kinase FOC90_29165 ENOG4105CB2 alcohol dehydrogenase FOC90_29170 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC90_29175 ENOG4105CJN penicillin-binding protein FOC90_29220 ENOG4107Y80 Major Facilitator superfamily FOC90_29240 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC90_29270 ENOG4107Y9U Membrane FOC90_29290 ENOG4105EGD dinuclear metal center protein, YbgI family FOC90_29295 ENOG4105M6F mutator MutT protein FOC90_29315 ENOG4105FCD Major Facilitator FOC90_29330 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC90_29335 ENOG4108Z4K mutator MutT protein FOC90_29360 ENOG4108XI2 Domain of unknown function (DUF1963) FOC90_29380 ENOG4108NRW Phospholipase, patatin family FOC90_29385 ENOG4105KWG Pfam:DUF1696 FOC90_29410 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC90_29420 ENOG4105PKS Excinuclease abc c subunit domain protein FOC90_29455 ENOG41087PP glycosyltransferase MGT family FOC90_29475 ENOG4107VFR oxidoreductase FOC90_29505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_29510 ENOG4105BZU Histidine kinase FOC90_29530 ENOG4107WD8 ABC transporter, permease FOC90_29545 ENOG4105DY8 decarboxylase FOC90_29560 ENOG4108IUM Glycogen debranching enzyme FOC90_29570 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FOC90_29585 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC90_29590 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC90_29595 ENOG4105FDR Membrane FOC90_29600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC90_29650 ENOG4105MSI germination protein ypeb FOC90_29680 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC90_29685 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC90_29690 ENOG4107Z3H Transcriptional regulator, TetR family FOC90_29710 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC90_29730 ENOG4105E98 transcriptional regulator DeoR family FOC90_29745 ENOG41062ES Transcriptional regulator FOC90_29765 ENOG4107QKR Dehydrogenase FOC90_29775 ENOG4107RUY (E1 component), alpha subunit FOC90_29790 ENOG4105E1F short-chain dehydrogenase reductase FOC90_29795 ENOG4105RHY Pfam:UPF0157 FOC90_29835 ENOG4107SQ8 Glycine betaine FOC90_29840 ENOG4108IJ7 Glycine betaine FOC90_29850 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC90_29865 ENOG4105E66 phosphoriboisomerase A FOC90_29870 ENOG41082BV acetyltransferase FOC90_29890 ENOG4108M1A Chitin-binding protein FOC90_29895 ENOG41087PP glycosyltransferase MGT family FOC90_29905 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOC90_29920 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC90_29925 ENOG4105MSB protein, conserved in bacteria FOC90_29950 ENOG4108Z7F N-acetyltransferase FOC90_29975 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOC90_29980 ENOG4105EEM helicase FOC90_29995 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC90_30045 ENOG4108M1A Chitin-binding protein FOC90_30065 ENOG4105BZG amino acid carrier protein FOC90_30070 ENOG4105C26 Dehydrogenase FOC90_30075 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC90_30085 ENOG4105CTU Proline racemase FOC90_30090 ENOG41080HI glycine oxidase FOC90_30100 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC90_30135 ENOG4107T5V SNARE associated Golgi FOC90_30145 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC90_30160 ENOG4105DTQ mandelate racemase muconate lactonizing FOC90_30175 ENOG4107SET aldo keto reductase FOC90_30210 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC90_30215 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC90_30220 ENOG4105BZU Histidine kinase FOC90_30225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC90_30250 ENOG4105DPN Oligoendopeptidase f FOC90_30255 ENOG4105EPR degv family FOC90_30315 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC90_30320 ENOG4106K7D Major facilitator family transporter FOC90_30345 ENOG4107BMA Transglycosylase associated protein FOC90_30360 ENOG41089UC methyltransferase, type 11 FOC90_30395 ENOG4105CHM Aminotransferase FOC90_30445 ENOG4105C02 permease FOC90_30460 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC90_30465 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC90_30470 ENOG4105D7T ABC transporter FOC90_30495 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC90_30530 ENOG4107VC0 DNA alkylation repair enzyme FOC90_30535 ENOG4105C6T cysteine synthase FOC90_30540 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC90_30575 ENOG4108ZCF integral membrane protein FOC90_30580 ENOG4105E0M Sulfatase FOC90_30585 ENOG4105C5H ABC transporter FOC90_30590 ENOG4105EYF MMPL domain protein FOC90_30595 ENOG41082JN Transcriptional regulator FOC90_30620 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC90_30625 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC90_30645 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC90_30660 ENOG41069ER domain protein FOC90_30690 ENOG4105D4B ABC, transporter FOC90_30700 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC90_30710 ENOG4105DKT Transcriptional regulator FOC90_30715 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC90_30725 ENOG41061GT Aldolase FOC90_30740 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC90_30770 ENOG4105II7 pyrroline-5-carboxylate reductase FOC90_30780 ENOG4107258 Transcriptional regulator FOC90_30795 ENOG4105E0Y RtcB Protein FOC90_30805 ENOG4105ECK Fatty Acid Desaturase FOC90_30815 ENOG4107RBI VanW family FOC90_30820 ENOG4105G6Z alkaline phosphatase FOC90_30830 ENOG4105VMP Transcriptional regulator FOC90_30850 ENOG41068WN FOC90_30875 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC90_30895 ENOG4105CSH Transporter FOC90_30900 ENOG4105C8Y Acetylornithine aminotransferase FOC90_30935 ENOG41090AA FOC90_30965 ENOG4108TVJ Nitroreductase FOC90_30970 ENOG4105FS7 Transcriptional regulator FOC90_30985 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC90_30990 ENOG4105WEC Molybdate metabolism regulator FOC90_30995 ENOG4105CMR udp-glucose 4-epimerase FOC90_31000 ENOG4105C19 ABC transporter FOC90_31025 ENOG4108XET gCN5-related N-acetyltransferase FOC90_31035 ENOG4105E09 nadh pyrophosphatase FOC90_31040 ENOG4108PCN EamA-like transporter family FOC90_31090 ENOG410635A Membrane FOC90_31100 ENOG4108IQI permease FOC90_31145 ENOG4108VJ1 Transcriptional regulator (CarD family FOC90_31155 ENOG4105BZU Histidine kinase FOC90_31180 ENOG4107RF6 penicillin-binding protein FOC90_31185 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC90_31215 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC90_31220 ENOG4107258 Transcriptional regulator FOC90_31230 ENOG4106N3A copper homeostasis protein cutc FOC90_31235 ENOG4108ZHR arsR family transcriptional regulator FOC90_31245 ENOG4105FDT acyl-CoA dehydrogenase FOC90_31260 ENOG4105DWD nucleoside recognition domain protein FOC90_31300 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC90_31325 ENOG4105E2A Dehydrogenase FOC90_31335 ENOG4108IJ0 Aspartate ammonia-lyase FOC90_31345 ENOG4108IMY Transcriptional regulator FOC90_31365 ENOG4108B31 Spore germination protein FOC90_31375 ENOG4105BZU Histidine kinase FOC90_31520 ENOG4108BUD transposase FOC90_31525 ENOG4108BUD transposase FOC90_31555 ENOG4108BUD transposase FOC90_31565 ENOG4108BUD transposase FOC90_31580 ENOG4105KRN Transcriptional regulator, abrb family FOC90_31605 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC90_31630 ENOG4105C19 ABC transporter FOC90_31635 ENOG4107RBB ABC transporter, permease FOC90_31705 ENOG4108BUD transposase FOC90_31735 ENOG4108BUD transposase FOC90_31855 ENOG4105E1K spore germination protein FOC90_31870 ENOG4108BUD transposase FOC90_31880 ENOG4105K70 DNA-binding protein FOC90_31885 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC90_31890 ENOG4105KRN Transcriptional regulator, abrb family FOC90_31905 ENOG4105C87 Aminotransferase class I and II FOC90_31910 ENOG410880H cysteine synthase FOC90_31915 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC90_31930 ENOG4108BUD transposase FOC90_31980 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC90_32085 ENOG4105DQ6 Transposase FOC90_32165 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FOC90_32255 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)