locus-tag class description BTF1_00015 ENOG4108N0M stress protein BTF1_00020 ENOG4106FN3 tellurium resistance protein BTF1_00025 ENOG4106FN3 tellurium resistance protein BTF1_00030 ENOG4107TS3 membrane protein, TerC BTF1_00035 ENOG4108TTB tellurium resistance protein BTF1_00050 ENOG41068PA UPF0435 protein BTF1_00055 ENOG4105KJF protein tyrosine phosphatase BTF1_00065 ENOG4107U9T Pfam:Ribonuclease_BN BTF1_00075 ENOG4105C59 p-type ATPase BTF1_00080 ENOG4108IPJ Membrane BTF1_00090 ENOG4105C3F Signal peptidase i BTF1_00100 ENOG4107ZTW SNARE associated Golgi BTF1_00115 ENOG410606W general stress protein BTF1_00120 ENOG4105UPD Calcium Proton BTF1_00155 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BTF1_00165 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BTF1_00175 ENOG4108JUB Transcriptional regulator BTF1_00185 ENOG4108IQI permease BTF1_00215 ENOG4105CSV Glutaminase BTF1_00225 ENOG4108A04 Beta-lactamase BTF1_00240 ENOG4105CKK Glycosyl transferase, family 2 BTF1_00245 ENOG4107QQG Dehydrogenase BTF1_00250 ENOG4105C3I Nad-dependent epimerase dehydratase BTF1_00255 ENOG4105CKK Glycosyl transferase, family 2 BTF1_00265 ENOG4105F1A Pyruvate formate-lyase BTF1_00285 ENOG4105CI2 imidazolone-5-propionate hydrolase BTF1_00290 ENOG4105ECP epimerase BTF1_00320 ENOG41067AE Membrane-bound metal-dependent hydrolase BTF1_00325 ENOG4105CEN a g-specific adenine glycosylase BTF1_00330 ENOG4106BXE BTF1_00350 ENOG4105BZ1 (ABC) transporter BTF1_00355 ENOG4107NBY Membrane BTF1_00360 ENOG4105CBC glutamate synthase BTF1_00370 ENOG4108IUW ABC transporter BTF1_00390 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTF1_00395 ENOG4105G5W regulator Fur family BTF1_00430 ENOG4108JQC penicillin-binding protein 1A BTF1_00435 ENOG4108R9S DSBA oxidoreductase BTF1_00440 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BTF1_00450 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BTF1_00455 ENOG4105BZU Histidine kinase BTF1_00465 ENOG4105CYN Serine protein kinase BTF1_00480 ENOG4105C94 Transporter BTF1_00495 ENOG4105DZ6 Band 7 protein BTF1_00505 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BTF1_00510 ENOG4108V9W transcriptional regulatory protein BTF1_00515 ENOG4105D4T Citrate transporter BTF1_00540 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BTF1_00545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTF1_00550 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BTF1_00555 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BTF1_00560 ENOG4105BZ7 extracellular solute-binding protein family 1 BTF1_00565 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BTF1_00570 ENOG4108STX response regulator BTF1_00575 ENOG4105US7 Histidine kinase BTF1_00600 ENOG4108MRH transcriptional regulatory protein BTF1_00610 ENOG4105C6K Malic enzyme BTF1_00620 ENOG4108UZ3 Transporter BTF1_00640 ENOG4105BZU Histidine kinase BTF1_00665 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BTF1_00670 ENOG4108JB9 formate dehydrogenase BTF1_00690 ENOG4105CUB amino acid BTF1_00700 ENOG4105C59 p-type ATPase BTF1_00705 ENOG4105DAP Nicotinate phosphoribosyltransferase BTF1_00740 ENOG41073R8 VanW family BTF1_00745 ENOG4108KGH TRANSCRIPTIONal BTF1_00750 ENOG4105D9N nucleoside BTF1_00755 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BTF1_00760 ENOG4105C37 (CBS) domain BTF1_00765 ENOG4108IJ0 Aspartate ammonia-lyase BTF1_00770 ENOG4105DAA L-lactate BTF1_00785 ENOG4105DUX Transporter BTF1_00790 ENOG4108MES Periplasmic binding protein BTF1_00795 ENOG4105DQ5 transport system permease protein BTF1_00800 ENOG4108IHU transport system permease protein BTF1_00805 ENOG4105E0A ABC, transporter BTF1_00820 ENOG4105EXW epimerase dehydratase BTF1_00830 ENOG4107T89 von Willebrand factor, type A BTF1_00835 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BTF1_00840 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTF1_00850 ENOG4105BZU Histidine kinase BTF1_00855 ENOG4105D5Q Arginine ornithine antiporter BTF1_00860 ENOG4107414 GntR family transcriptional regulator BTF1_00865 ENOG4105C5Y PTS System BTF1_00870 ENOG4105CG3 alpha amylase, catalytic region BTF1_00890 ENOG4105E1K spore germination protein BTF1_00905 ENOG4105BZG amino acid carrier protein BTF1_00915 ENOG4105CDA abc transporter atp-binding protein BTF1_00920 ENOG4105CT1 (ABC) transporter BTF1_00925 ENOG4105EAD ABC transporter BTF1_00930 ENOG4105DRP amino acid AbC transporter BTF1_00935 ENOG4108IQI permease BTF1_00950 ENOG4105GFR rna polymerase sigma factor BTF1_00960 ENOG4105D29 Helix-turn-helix type 11 domain protein BTF1_00965 ENOG4105NAE bifunctional deaminase-reductase domain protein BTF1_00970 ENOG4105BZU Histidine kinase BTF1_00995 ENOG4105CHH sulfate transporter BTF1_01000 ENOG41068KF Universal stress protein BTF1_01010 ENOG4105CXY transporter BTF1_01015 ENOG41067TZ transcriptional regulator, MarR family BTF1_01020 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTF1_01025 ENOG4105ETE Transcriptional regulator (LacI family BTF1_01030 ENOG4108RVA ribokinase BTF1_01040 ENOG4105C2J ABC transporter BTF1_01045 ENOG4105CNN ABC, transporter BTF1_01050 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BTF1_01055 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BTF1_01095 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BTF1_01120 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BTF1_01125 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTF1_01130 ENOG41069ER domain protein BTF1_01135 ENOG4105VZ8 Transcriptional regulator BTF1_01140 ENOG4107D63 BTF1_01155 ENOG4105DUX Transporter BTF1_01180 ENOG4105C85 amino acid BTF1_01185 ENOG4105C7N Xanthine uracil vitamin C permease BTF1_01200 ENOG4105MA6 gCN5-related N-acetyltransferase BTF1_01225 ENOG4105BZ9 Cytochrome C oxidase, subunit I BTF1_01230 ENOG4105E2S oxidase) subunit II BTF1_01250 ENOG4106CAD Protein of unknown function (DUF3311) BTF1_01255 ENOG4105E1V na solute symporter BTF1_01270 ENOG4108NHD germination protein BTF1_01280 ENOG4105CE1 Ferrous iron transport protein b BTF1_01285 ENOG4105CE1 Ferrous iron transport protein b BTF1_01290 ENOG4105CE1 Ferrous iron transport protein b BTF1_01295 ENOG4105CVA phosphate BTF1_01300 ENOG4105C8U phosphate abc transporter BTF1_01305 ENOG4105E2Z phosphate ABC transporter (Permease BTF1_01320 ENOG41080XQ Signal transduction protein with cbs domains BTF1_01340 ENOG4105ETU transcriptional activator (TenA BTF1_01350 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BTF1_01360 ENOG4108VEU Thiamine monophosphate synthase BTF1_01365 ENOG41080HI glycine oxidase BTF1_01380 ENOG4105D06 uba thif-type nad fad binding protein BTF1_01385 ENOG4105DWF phosphomethylpyrimidine kinase BTF1_01430 ENOG4108INS Transcriptional regulator BTF1_01445 ENOG4105C7N Xanthine uracil vitamin C permease BTF1_01455 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BTF1_01470 ENOG4105K63 Thioredoxin BTF1_01490 ENOG4108B31 Spore germination protein BTF1_01510 ENOG4107Y03 Nitroreductase BTF1_01515 ENOG4105ED1 spovr family BTF1_01535 ENOG4108TCS Glutamyl endopeptidase BTF1_01545 ENOG4105XTG Pfam:DUF156 BTF1_01550 ENOG4105VFE sira family BTF1_01555 ENOG4107TPS domain protein BTF1_01560 ENOG4105VFE sira family BTF1_01565 ENOG4105VFE sira family BTF1_01575 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BTF1_01580 ENOG41087NI Sulfite exporter TauE/SafE BTF1_01590 ENOG4108KGH TRANSCRIPTIONal BTF1_01615 ENOG4105EMD TRANSCRIPTIONal BTF1_01620 ENOG4105VCP PTS System BTF1_01625 ENOG4105VZJ PTS System BTF1_01650 ENOG41069ER domain protein BTF1_01655 ENOG4107RBB ABC transporter, permease BTF1_01660 ENOG4105C19 ABC transporter BTF1_01690 ENOG4105WEF catalase BTF1_01725 ENOG4107T5V SNARE associated Golgi BTF1_01760 ENOG4105CUB amino acid BTF1_01765 ENOG4107RWR Sodium hydrogen exchanger BTF1_01775 ENOG4106KNT transcriptional regulator BTF1_01815 ENOG4108YXU transcriptional regulator AsnC family BTF1_01825 ENOG4105UBK short-chain dehydrogenase reductase BTF1_01830 ENOG4105W1Y Transcriptional regulator BTF1_01835 ENOG4105KPY Small multidrug resistance protein BTF1_01875 ENOG4107RKG DJ-1/PfpI family BTF1_01880 ENOG4105CH6 catalase BTF1_01890 ENOG4105D5Q Arginine ornithine antiporter BTF1_01895 ENOG4105C26 Dehydrogenase BTF1_01900 ENOG4105BZ1 (ABC) transporter BTF1_01905 ENOG4105BZ1 (ABC) transporter BTF1_01915 ENOG4105DRP amino acid AbC transporter BTF1_01920 ENOG4105CDA abc transporter atp-binding protein BTF1_01935 ENOG410839P BTF1_01970 ENOG4107FQX Alpha-acetolactate decarboxylase BTF1_01990 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein BTF1_01995 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTF1_02000 ENOG4105D4P Coproporphyrinogen iii oxidase BTF1_02005 ENOG4105CEY Amp-dependent synthetase and ligase BTF1_02015 ENOG4105CHH sulfate transporter BTF1_02040 ENOG4105CGU Enoyl-CoA hydratase BTF1_02060 ENOG4105DER m42 family BTF1_02085 ENOG4105CIF Ornithine Cyclodeaminase BTF1_02100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTF1_02110 ENOG4108JQ7 (ABC) transporter BTF1_02145 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase BTF1_02160 ENOG4105D06 uba thif-type nad fad binding protein BTF1_02165 ENOG4107SFI Major Facilitator superfamily BTF1_02235 ENOG4108IBT Inherit from COG: transposase BTF1_02240 ENOG4108IBT Inherit from COG: transposase BTF1_02250 ENOG4105GMB type VI secretion system effector, hcp1 family BTF1_02305 ENOG4105CSH Transporter BTF1_02315 ENOG4108MRH transcriptional regulatory protein BTF1_02360 ENOG4105C4R Atp-dependent dna helicase BTF1_02380 ENOG4105CDU Replicative dna helicase BTF1_02410 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTF1_02495 ENOG4105F6J Alpha beta hydrolase fold BTF1_02565 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BTF1_02575 ENOG4105F27 Major Facilitator BTF1_02580 ENOG4105WAB arsR family transcriptional regulator BTF1_02590 ENOG4105CMT Dihydroxyacetone kinase BTF1_02600 ENOG4105CMT Dihydroxyacetone kinase BTF1_02730 ENOG4105WN5 stage II sporulation protein BTF1_02740 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTF1_02750 ENOG4108MJI response regulator BTF1_02755 ENOG4105BZU Histidine kinase BTF1_02760 ENOG4105BZU Histidine kinase BTF1_02800 ENOG4105D7V transposase BTF1_02815 ENOG4107QHE Choloylglycine hydrolase BTF1_02830 ENOG4107VRP DNA repair exonuclease BTF1_02835 ENOG4106D4I domain protein BTF1_02850 ENOG410829K Lysine exporter protein (Lyse ygga) BTF1_02875 ENOG4108MUZ hydrolase BTF1_02900 ENOG4105F0F Oxalate decarboxylase BTF1_02905 ENOG41067QW Transcriptional regulator BTF1_02915 ENOG4105D7V transposase BTF1_02920 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BTF1_02935 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BTF1_02955 ENOG4105EMN RNA polymerase sigma factor BTF1_02975 ENOG4105EEM helicase BTF1_02980 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTF1_03005 ENOG4105K59 histidine triad (HIT) protein BTF1_03035 ENOG410905X membrane-flanked domain protein BTF1_03040 ENOG4105CKV Membrane BTF1_03080 ENOG410905X membrane-flanked domain protein BTF1_03085 ENOG4105CKV Membrane BTF1_03090 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BTF1_03095 ENOG4105BZ4 penicillin-binding protein BTF1_03105 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BTF1_03110 ENOG4105C1Q protoporphyrinogen oxidase BTF1_03140 ENOG4105ECB domain protein BTF1_03170 ENOG4106AXD BTF1_03175 ENOG4108RQ5 Beta-lactamase domain-containing protein BTF1_03180 ENOG4105DF9 Lipoate-protein, ligase BTF1_03190 ENOG4105CEY Amp-dependent synthetase and ligase BTF1_03245 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BTF1_03255 ENOG4105ENX hydrolase BTF1_03260 ENOG4107RN3 metallophosphoesterase BTF1_03265 ENOG4107TVP HD domain protein BTF1_03275 ENOG4108AEY RNA polymerase sigma factor BTF1_03280 ENOG41086D8 Transcriptional regulator BTF1_03295 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTF1_03315 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BTF1_03320 ENOG4105C8Q Methyl-accepting chemotaxis BTF1_03330 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) BTF1_03340 ENOG4107QP3 malate synthase g BTF1_03360 ENOG4105VEQ Cold shock protein BTF1_03375 ENOG4105XVF Competence transcription factor BTF1_03440 ENOG4105ERH Fumarylacetoacetate hydrolase BTF1_03445 ENOG4105C8Y Acetylornithine aminotransferase BTF1_03460 ENOG4105CAQ asparagine synthetase BTF1_03465 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BTF1_03470 ENOG4105CH6 catalase BTF1_03475 ENOG4105BZU Histidine kinase BTF1_03495 ENOG4105QNR S1 RNA binding domain protein BTF1_03500 ENOG4105CNA YD repeat protein BTF1_03550 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTF1_03560 ENOG4107AYK membrAne BTF1_03565 ENOG41073B9 BTF1_03575 ENOG4108KP7 hydrolase BTF1_03585 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BTF1_03610 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BTF1_03615 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BTF1_03635 ENOG4105C31 Tryptophanyl-tRNA synthetase BTF1_03650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTF1_03655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTF1_03665 ENOG4108JQ7 (ABC) transporter BTF1_03670 ENOG4105UQX Mate efflux family protein BTF1_03685 ENOG4108ZCF integral membrane protein BTF1_03695 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTF1_03705 ENOG4105DPN Oligoendopeptidase f BTF1_03720 ENOG4108Z18 K06886 hemoglobin BTF1_03725 ENOG4105MIX Adenylate cyclase BTF1_03740 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BTF1_03745 ENOG4105EMS pseudouridine synthase BTF1_03765 ENOG4105K64 Glycosyl transferase, family 2 BTF1_03810 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BTF1_03815 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BTF1_03825 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BTF1_03900 ENOG4105CK7 Sodium proline symporter BTF1_03910 ENOG4105CRQ synthase (Component I) BTF1_03915 ENOG4105DDQ anthranilate synthase BTF1_04005 ENOG4105C7S Dehydrogenase BTF1_04015 ENOG4105VZ8 Transcriptional regulator BTF1_04050 ENOG4108IUX (ABC) transporter BTF1_04055 ENOG4105RHA ABC transporter, permease BTF1_04065 ENOG4105DQ6 Transposase BTF1_04080 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BTF1_04090 ENOG4105DZ1 carboxypeptidase BTF1_04095 ENOG4105VFR signal peptidase BTF1_04130 ENOG4105C26 Dehydrogenase BTF1_04135 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTF1_04140 ENOG4105F38 ABC transporter, permease BTF1_04145 ENOG4105D38 putrescine abc transporter BTF1_04150 ENOG4107RUE extracellular solute-binding protein family 1 BTF1_04155 ENOG410841Q phosphoesterase PA-phosphatase related protein BTF1_04160 ENOG4105EYF MMPL domain protein BTF1_04170 ENOG4108YBP pseudouridine synthase BTF1_04180 ENOG4105K4I Scp-like extracellular BTF1_04185 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BTF1_04190 ENOG4105CQB FAD linked oxidase domain protein BTF1_04205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_04210 ENOG4105BZU Histidine kinase BTF1_04215 ENOG4105JXH GntR family transcriptional regulator BTF1_04235 ENOG4106A3R peptidase BTF1_04245 ENOG4108QTI )-transporter BTF1_04250 ENOG4107TS3 membrane protein, TerC BTF1_04255 ENOG4105CZN Potassium uptake protein BTF1_04260 ENOG410681C small acid-soluble spore protein BTF1_04265 ENOG4108Z7G MaoC domain protein dehydratase BTF1_04285 ENOG4105CHR reductase BTF1_04315 ENOG4105C4Y ABC transporter BTF1_04320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTF1_04325 ENOG4107RCV ABC transporter, permease BTF1_04345 ENOG4105E98 transcriptional regulator DeoR family BTF1_04360 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BTF1_04370 ENOG4105PXI polysaccharide deacetylase BTF1_04380 ENOG4105BZU Histidine kinase BTF1_04385 ENOG41090MY MarR family Transcriptional regulator BTF1_04395 ENOG4106DF1 BTF1_04410 ENOG4105BZU Histidine kinase BTF1_04420 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BTF1_04425 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BTF1_04465 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BTF1_04470 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BTF1_04475 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BTF1_04480 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BTF1_04485 ENOG4105CZV ABC transporter BTF1_04495 ENOG4105CJ1 ABC, transporter BTF1_04535 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BTF1_04540 ENOG4105EA8 2-Nitropropane dioxygenase BTF1_04545 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BTF1_04555 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BTF1_04580 ENOG4105NQC Flavodoxin BTF1_04620 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BTF1_04655 ENOG4105CZN Potassium uptake protein BTF1_04660 ENOG41063Y9 BTF1_04665 ENOG4105KBJ sporulation protein ytfj BTF1_04685 ENOG4105CM2 brancheD-chain amino acid aminotransferase BTF1_04690 ENOG4105C7K acetolactate synthase BTF1_04695 ENOG4108ZP8 Acetolactate synthase small subunit BTF1_04700 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BTF1_04735 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BTF1_04770 ENOG4107RVV histidinol phosphate phosphatase, hisj family BTF1_04785 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BTF1_04790 ENOG4105E0M Sulfatase BTF1_04800 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BTF1_04820 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BTF1_04825 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BTF1_04835 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BTF1_04840 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BTF1_04845 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BTF1_04850 ENOG4105C8J )-transporter BTF1_04875 ENOG4105DFD Na H antiporter BTF1_04895 ENOG4105ENE Histidine kinase BTF1_04900 ENOG4105WH1 Two component transcriptional regulator luxr family BTF1_04920 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTF1_04945 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BTF1_04965 ENOG4105CJ3 phosphate transporter BTF1_04970 ENOG4107GRR phosphate transport regulator BTF1_04975 ENOG4105BZ4 penicillin-binding protein BTF1_04990 ENOG4105BZU Histidine kinase BTF1_04995 ENOG4105I3N Conserved Protein BTF1_05015 ENOG4105BZU Histidine kinase BTF1_05045 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTF1_05050 ENOG4105DZ1 carboxypeptidase BTF1_05055 ENOG4108JIC nucleoside recognition domain protein BTF1_05065 ENOG4105FE9 pseudouridine synthase BTF1_05070 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTF1_05075 ENOG4107TWT Cytochrome c biogenesis protein BTF1_05080 ENOG4105CRE cytochrome C BTF1_05085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_05090 ENOG4105BZU Histidine kinase BTF1_05095 ENOG4108WBT adenosyltransferase BTF1_05100 ENOG41063SB peptidase BTF1_05110 ENOG4108SAX Membrane BTF1_05125 ENOG4105C9U ATP-dependent DNA helicase RecQ BTF1_05130 ENOG4105I7S Abortive infection protein BTF1_05140 ENOG4107RGJ metallophosphoesterase BTF1_05145 ENOG4108XDN Transcriptional regulator BTF1_05150 ENOG4108S6Z Negative regulator of genetic competence BTF1_05175 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BTF1_05180 ENOG4107RB3 L-asparaginase BTF1_05215 ENOG4105S2F BTF1_05220 ENOG41065D1 BTF1_05250 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BTF1_05265 ENOG4105XXQ heptaprenyl diphosphate synthase component I BTF1_05275 ENOG4105EAH synthase BTF1_05280 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BTF1_05285 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BTF1_05300 ENOG41068YB TPR repeat-containing protein BTF1_05315 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BTF1_05320 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BTF1_05355 ENOG4108JYZ YitT family BTF1_05360 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BTF1_05375 ENOG4105FJR Lmbe family BTF1_05380 ENOG4105CPK Glycosyl transferase (Group 1 BTF1_05415 ENOG4105DVT helicase BTF1_05420 ENOG4105YAC BTF1_05440 ENOG4105CSM endonuclease III BTF1_05450 ENOG4105BZ4 penicillin-binding protein BTF1_05505 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BTF1_05515 ENOG4105DVT helicase BTF1_05520 ENOG4105CTD carboxy-peptidase BTF1_05535 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BTF1_05545 ENOG4105C2W permease BTF1_05550 ENOG4105DHF Membrane BTF1_05560 ENOG410890F Dynamin family BTF1_05570 ENOG4108W0I acetyltransferase BTF1_05580 ENOG4105KHC sulfurtransferase BTF1_05595 ENOG4106032 Glutathionylspermidine synthase BTF1_05625 ENOG4105HTX biosynthesis protein BTF1_05655 ENOG4105CPK Glycosyl transferase (Group 1 BTF1_05670 ENOG4108SZE gCN5-related N-acetyltransferase BTF1_05690 ENOG41081VK Ribonuclease BTF1_05755 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTF1_05765 ENOG4107RWR Sodium hydrogen exchanger BTF1_05780 ENOG4108Z5V transcriptional regulator, merr family BTF1_05790 ENOG4105H67 Protein of unknown function (DUF421) BTF1_05795 ENOG41080C8 DUF218 domain BTF1_05830 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTF1_05840 ENOG4107R0U MotA TolQ exbB proton channel BTF1_05845 ENOG4105ER2 Ompa motb domain protein BTF1_05850 ENOG4107YTP response regulator receiver protein BTF1_05855 ENOG4105CBS Chea signal transduction histidine kinase BTF1_05860 ENOG4105DD5 Flagellar motor switch protein BTF1_05875 ENOG4105BZU Histidine kinase BTF1_05900 ENOG4105E1Q flagellar hook-associated protein BTF1_05905 ENOG4105DTJ flagellar hook-associated protein BTF1_05925 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BTF1_05930 ENOG4108ZC9 flagellar basal-body rod protein flgc BTF1_05935 ENOG41075Z6 flagellar hook-basal body complex protein fliE BTF1_05940 ENOG4107U2N Flagellar M-ring protein BTF1_05945 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BTF1_05975 ENOG4105BZE flagellar hook protein, FlgE BTF1_05990 ENOG4107R88 Chemotaxis protein (CheV) BTF1_06020 ENOG4105I03 Flagellin BTF1_06025 ENOG4105E4C Lytic transglycosylase catalytic BTF1_06035 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BTF1_06040 ENOG4105DD5 Flagellar motor switch protein BTF1_06050 ENOG4105CN7 Flagellar biosynthetic protein FliP BTF1_06055 ENOG4105VS8 Flagellar biosynthetic protein fliq BTF1_06065 ENOG4105D00 flagellar biosynthetic protein flhB BTF1_06070 ENOG4105D7B Flagellar biosynthesis protein flha BTF1_06075 ENOG4105FZW flagellar biosynthesis regulator FlhF BTF1_06080 ENOG4105KTQ flagellar basal-body rod protein BTF1_06085 ENOG4105CPU Monooxygenase BTF1_06090 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTF1_06120 ENOG4105KAC Antibiotic biosynthesis monooxygenase BTF1_06125 ENOG4107QZ7 Cellulose synthase catalytic subunit BTF1_06150 ENOG4105DUM transcriptional regulator, lysR family BTF1_06155 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTF1_06165 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BTF1_06170 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BTF1_06200 ENOG4105CVJ phosphoglycerate mutase BTF1_06210 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BTF1_06220 ENOG4105K56 Transcriptional regulator BTF1_06230 ENOG4105CAQ asparagine synthetase BTF1_06250 ENOG4105PGM cation diffusion facilitator family transporter BTF1_06265 ENOG4105CKI cobalamin synthesis protein BTF1_06270 ENOG4108PJD permease BTF1_06285 ENOG4105DFD Na H antiporter BTF1_06290 ENOG4105VUF Transcriptional regulator BTF1_06300 ENOG4105C9Q fumarate hydratase class II BTF1_06320 ENOG4107QJQ Mate efflux family protein BTF1_06325 ENOG4105EC3 peptidase S51, dipeptidase E BTF1_06345 ENOG4107QIV Cytochrome c biogenesis protein BTF1_06350 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTF1_06365 ENOG4107JM4 Tetratricopeptide repeat BTF1_06385 ENOG4106BRA Membrane BTF1_06420 ENOG4105CJ1 ABC, transporter BTF1_06440 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BTF1_06450 ENOG4108IJ0 Aspartate ammonia-lyase BTF1_06455 ENOG4105C6K Malic enzyme BTF1_06510 ENOG4105FVX BTF1_06515 ENOG4105E09 nadh pyrophosphatase BTF1_06530 ENOG4105CSR polyphosphate kinase 2 BTF1_06535 ENOG4105U3E Transcriptional regulator BTF1_06545 ENOG4105DXI Major Facilitator superfamily BTF1_06555 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BTF1_06560 ENOG4105EU0 Major facilitator Superfamily BTF1_06565 ENOG4105C6T cysteine synthase BTF1_06585 ENOG4105C8J )-transporter BTF1_06595 ENOG4105X5K response regulator receiver protein BTF1_06600 ENOG4105H67 Protein of unknown function (DUF421) BTF1_06630 ENOG4105CHR reductase BTF1_06635 ENOG4105CM2 brancheD-chain amino acid aminotransferase BTF1_06640 ENOG4105C7K acetolactate synthase BTF1_06650 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BTF1_06660 ENOG4105C7B Threonine dehydratase BTF1_06680 ENOG4105C6X Major Facilitator BTF1_06685 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BTF1_06700 ENOG4105DY9 regulatoR BTF1_06705 ENOG4105CYC Transferase BTF1_06730 ENOG41068WN BTF1_06750 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BTF1_06765 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BTF1_06775 ENOG4105C0X amino acid BTF1_06810 ENOG410849A acetyltransferase, (GNAT) family BTF1_06815 ENOG4105K8R UPF0145 protein BTF1_06830 ENOG4107RHR regulatoR BTF1_06840 ENOG4105D9N nucleoside BTF1_06845 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BTF1_06850 ENOG4105KG3 cytidine deaminase BTF1_06900 ENOG4107RAQ aminopeptidase BTF1_06910 ENOG4107R16 Multicopper oxidase BTF1_06950 ENOG4108T5E Copper resistance protein BTF1_06955 ENOG4105KTB nuclear export factor GLE1 BTF1_06960 ENOG4107RT3 EamA-like transporter family BTF1_06965 ENOG4105GZI Transcriptional regulator BTF1_06970 ENOG4108Z40 Transcriptional regulator BTF1_06975 ENOG4107ZXU DSBA oxidoreductase BTF1_06980 ENOG4108TVJ Nitroreductase BTF1_06990 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BTF1_06995 ENOG4106F5Q Membrane BTF1_07000 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BTF1_07010 ENOG4105CKI cobalamin synthesis protein BTF1_07020 ENOG4105C0Z ABC transporter BTF1_07025 ENOG4108IV0 ABC, transporter BTF1_07030 ENOG4105C32 Amino acid ABC transporter (Permease) BTF1_07040 ENOG4105EGI Transcriptional regulator BTF1_07080 ENOG4105C4M (Ubiquinol oxidase) subunit I BTF1_07085 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BTF1_07090 ENOG4108JJ9 ABC, transporter BTF1_07095 ENOG4108JJ8 (ABC) transporter BTF1_07105 ENOG4105K64 Glycosyl transferase, family 2 BTF1_07115 ENOG4108UT6 Transferase hexapeptide repeat containing protein BTF1_07170 ENOG4105BZ1 (ABC) transporter BTF1_07175 ENOG4105EFI regulatoR BTF1_07180 ENOG4105BZU Histidine kinase BTF1_07190 ENOG4108VQJ O-methyltransferase BTF1_07200 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BTF1_07205 ENOG4108ZJ4 polysaccharide deacetylase BTF1_07230 ENOG4105D6E homoserine dehydrogenase BTF1_07255 ENOG4108KGH TRANSCRIPTIONal BTF1_07260 ENOG4107VMI polysaccharide deacetylase BTF1_07270 ENOG4105KT7 mgtC SapB transporter BTF1_07275 ENOG4105VRR gCN5-related N-acetyltransferase BTF1_07285 ENOG4105DUU IucA IucC family protein BTF1_07290 ENOG4105CEY Amp-dependent synthetase and ligase BTF1_07305 ENOG4108WBH protein TIM barrel BTF1_07310 ENOG4105YWU small acid-soluble spore protein BTF1_07320 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BTF1_07325 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTF1_07380 ENOG4105KRN Transcriptional regulator, abrb family BTF1_07390 ENOG4105YVS arsR family transcriptional regulator BTF1_07395 ENOG4105CPC Aldo Keto reductase BTF1_07400 ENOG4107XZQ multidrug resistance protein BTF1_07425 ENOG4105C8Q Methyl-accepting chemotaxis BTF1_07440 ENOG4108K88 Membrane BTF1_07445 ENOG4108WPJ Ferritin-like domain BTF1_07460 ENOG4105DEN Luciferase family BTF1_07475 ENOG4105VMI -acetyltransferase BTF1_07480 ENOG4107QM2 Aldo Keto reductase BTF1_07485 ENOG4105CKI cobalamin synthesis protein BTF1_07495 ENOG4105DSE periplasmic solute binding protein BTF1_07505 ENOG4105K4T epimerase BTF1_07515 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BTF1_07540 ENOG4105CVJ phosphoglycerate mutase BTF1_07560 ENOG4107T5V SNARE associated Golgi BTF1_07575 ENOG4108PJD permease BTF1_07585 ENOG4108S4H thioesterase Superfamily protein BTF1_07595 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTF1_07615 ENOG4105SXS Protein of unknown function (DUF456) BTF1_07620 ENOG4105C37 (CBS) domain BTF1_07650 ENOG4108Z7R Chaperone CsaA BTF1_07665 ENOG4108ZRV stage ii sporulation protein p BTF1_07675 ENOG4108VXD carboxy-peptidase BTF1_07705 ENOG4108ZRV stage ii sporulation protein p BTF1_07715 ENOG4108X4Q Hydrolase BTF1_07720 ENOG41082F9 transcriptional regulator BTF1_07725 ENOG4105D94 Major Facilitator Superfamily BTF1_07735 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BTF1_07740 ENOG4107RBS Methyltransferase BTF1_07755 ENOG41087PP glycosyltransferase MGT family BTF1_07760 ENOG4108JYZ YitT family BTF1_07765 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTF1_07795 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BTF1_07820 ENOG4106PAW secretion accessory protein EsaA YueB BTF1_07830 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) BTF1_07960 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTF1_07970 ENOG4105KBJ sporulation protein ytfj BTF1_07995 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTF1_08015 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BTF1_08020 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BTF1_08030 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BTF1_08035 ENOG4105EMN RNA polymerase sigma factor BTF1_08045 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BTF1_08055 ENOG4105CNW domain protein BTF1_08065 ENOG4108V06 Glutathione peroxidase BTF1_08080 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BTF1_08090 ENOG4108IUE nitrate reductase beta subunit BTF1_08095 ENOG4105R3A Nitrate reductase BTF1_08105 ENOG4107V6Q Cyclic nucleotide-binding domain BTF1_08110 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BTF1_08115 ENOG4105D06 uba thif-type nad fad binding protein BTF1_08120 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTF1_08125 ENOG4108ZAF Molybdopterin BTF1_08155 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BTF1_08160 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BTF1_08165 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BTF1_08170 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BTF1_08175 ENOG4108IFG nitrite reductase, (NAD(P)H) BTF1_08180 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BTF1_08215 ENOG4105MCT stage V sporulation protein S BTF1_08250 ENOG4105C5H ABC transporter BTF1_08265 ENOG4108UUM single-stranded DNA-binding protein BTF1_08295 ENOG4107YX5 Pfam:DUF548 BTF1_08300 ENOG4105C75 arginyL-tRNA synthetase BTF1_08330 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BTF1_08350 ENOG4105C5S asparaginyl-tRNA synthetase BTF1_08355 ENOG4105C8J )-transporter BTF1_08360 ENOG4108EF6 Proline imino-peptidase BTF1_08375 ENOG4107XGZ Hydrolase BTF1_08380 ENOG4105CY2 Citrate transporter BTF1_08400 ENOG4105KD7 acetyltransferase BTF1_08415 ENOG4105VMP Transcriptional regulator BTF1_08420 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BTF1_08445 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BTF1_08475 ENOG4107RVG penicillin-binding protein BTF1_08485 ENOG4105E9Q Acyl-transferase BTF1_08490 ENOG4108UT2 hemolysin iii BTF1_08500 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BTF1_08510 ENOG4108RCR degv family BTF1_08520 ENOG4108KF3 Electron transport protein SCO1 SenC BTF1_08525 ENOG4107Y70 Heat shock protein BTF1_08530 ENOG4105CAQ asparagine synthetase BTF1_08545 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BTF1_08550 ENOG4108MES Periplasmic binding protein BTF1_08555 ENOG4105F0I Aminotransferase BTF1_08585 ENOG4105D8X mechanosensitive ion channel BTF1_08590 ENOG4105BZU Histidine kinase BTF1_08595 ENOG4105WH1 Two component transcriptional regulator luxr family BTF1_08600 ENOG4106KNT transcriptional regulator BTF1_08605 ENOG4107ZY0 Phenazine biosynthesis-like protein BTF1_08625 ENOG4105CMG Carbohydrate kinase BTF1_08630 ENOG4105C6Z Gluconate BTF1_08640 ENOG4108YV3 Protein of unknown function (DUF2711) BTF1_08665 ENOG4108IJ8 ABC transporter BTF1_08670 ENOG4105E90 ABC transporter BTF1_08705 ENOG4105C37 (CBS) domain BTF1_08730 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTF1_08745 ENOG4107S4Y M20 DapE family protein YgeY BTF1_08750 ENOG4108TSC N-acetyltransferase BTF1_08755 ENOG4108JUB Transcriptional regulator BTF1_08760 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BTF1_08805 ENOG410841Q phosphoesterase PA-phosphatase related protein BTF1_08820 ENOG4105SZ6 Thioredoxin BTF1_08860 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTF1_08920 ENOG4105BZ4 penicillin-binding protein BTF1_08930 ENOG4105CZM Major Facilitator BTF1_08935 ENOG4105W8X HesB YadR YfhF-family protein BTF1_08945 ENOG4105DXD 2-methylcitrate dehydratase BTF1_08950 ENOG4105CR4 methylisocitrate lyase BTF1_08960 ENOG4105C1G acyl-Coa dehydrogenase BTF1_08965 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BTF1_08975 ENOG4105N14 lysine exporter protein LysE YggA BTF1_08980 ENOG4105E39 Enoyl-CoA hydratase BTF1_08995 ENOG4107RFY SbcCD D subunit BTF1_09000 ENOG4105EYH Exonuclease BTF1_09020 ENOG4105FCD Major Facilitator BTF1_09025 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BTF1_09030 ENOG4105E4F Isochorismate synthase BTF1_09035 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BTF1_09040 ENOG4105WQI isochorismatase BTF1_09045 ENOG4105CEY Amp-dependent synthetase and ligase BTF1_09050 ENOG4105WQT MbtH domain protein BTF1_09055 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTF1_09070 ENOG4105K70 DNA-binding protein BTF1_09090 ENOG4105BZG amino acid carrier protein BTF1_09110 ENOG4105FE9 pseudouridine synthase BTF1_09115 ENOG4105C22 threonyL-tRNA synthetase BTF1_09120 ENOG4105C19 ABC transporter BTF1_09150 ENOG41081I9 integral membrane protein BTF1_09160 ENOG4108Y4K DNA-binding transcriptional activator BTF1_09180 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BTF1_09190 ENOG4105EYF MMPL domain protein BTF1_09215 ENOG4105WCN acetyltransferase BTF1_09240 ENOG4105C1Q protoporphyrinogen oxidase BTF1_09250 ENOG41068WN BTF1_09280 ENOG4107V2S Transcriptional regulator BTF1_09285 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BTF1_09295 ENOG4105DND Transcriptional regulator BTF1_09300 ENOG4108RPX mosc domain containing protein BTF1_09315 ENOG4105BZ1 (ABC) transporter BTF1_09320 ENOG4105BZ1 (ABC) transporter BTF1_09350 ENOG4108JCI Transcriptional regulator BTF1_09385 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BTF1_09390 ENOG4108KPJ rna polymerase sigma factor BTF1_09415 ENOG4105F32 YngK protein BTF1_09440 ENOG4105RD7 BadF BadG BcrA BcrD BTF1_09445 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BTF1_09450 ENOG4107STF Involved in phosphonate degradation (By similarity) BTF1_09455 ENOG4105C7B Threonine dehydratase BTF1_09460 ENOG4108INS Transcriptional regulator BTF1_09475 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BTF1_09485 ENOG4105C1J atp-dependent rna helicase BTF1_09490 ENOG41088CC tellurite resistance protein tehB BTF1_09500 ENOG4108I0C methyltransferase BTF1_09505 ENOG4107RA9 decarboxylase BTF1_09545 ENOG4105CIN aminoacyl-histidine dipeptidase BTF1_09575 ENOG4105KRN Transcriptional regulator, abrb family BTF1_09585 ENOG4105EJ9 Membrane BTF1_09630 ENOG4105W8Z 4'-phosphopantetheinyl transferase BTF1_09640 ENOG4105CHR reductase BTF1_09700 ENOG4108W0I acetyltransferase BTF1_09705 ENOG4107QQG Dehydrogenase BTF1_09710 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BTF1_09715 ENOG4108IAJ Nad-dependent epimerase dehydratase BTF1_09720 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BTF1_09735 ENOG4105FJR Lmbe family BTF1_09745 ENOG4105IIU Aminopeptidase BTF1_09750 ENOG4108SC4 )-transporter BTF1_09800 ENOG4108IMY Transcriptional regulator BTF1_09815 ENOG4107VMI polysaccharide deacetylase BTF1_09855 ENOG4107RVG penicillin-binding protein BTF1_09870 ENOG4107RF6 penicillin-binding protein BTF1_09880 ENOG4105DQ6 Transposase BTF1_09885 ENOG4107RF6 penicillin-binding protein BTF1_09895 ENOG4105DIN metallophosphoesterase BTF1_09920 ENOG4107Z3H Transcriptional regulator, TetR family BTF1_09935 ENOG4105C1G acyl-Coa dehydrogenase BTF1_09940 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BTF1_09945 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BTF1_09950 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BTF1_09955 ENOG4105E39 Enoyl-CoA hydratase BTF1_09960 ENOG4107QX3 carboxylase BTF1_09965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BTF1_09990 ENOG4105DZ1 carboxypeptidase BTF1_10005 ENOG4105T9C HD domain BTF1_10020 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BTF1_10045 ENOG41075H3 AraC family transcriptional regulator BTF1_10075 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BTF1_10085 ENOG4105CHR reductase BTF1_10090 ENOG4105KVH Transcriptional regulator BTF1_10160 ENOG410900G Protein of unknown function (DUF421) BTF1_10175 ENOG4108V4B ThiJ pfpI BTF1_10185 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BTF1_10190 ENOG4105DK7 lysyl-tRNA synthetase BTF1_10215 ENOG4106NZI LysR family Transcriptional regulator BTF1_10220 ENOG4105CPC Aldo Keto reductase BTF1_10265 ENOG4105D6E homoserine dehydrogenase BTF1_10275 ENOG4105CPF Cell wall formation (By similarity) BTF1_10280 ENOG4105ETU transcriptional activator (TenA BTF1_10370 ENOG410667J hydrolase BTF1_10375 ENOG4105BZU Histidine kinase BTF1_10380 ENOG4107RF6 penicillin-binding protein BTF1_10405 ENOG4108FPN Integrase BTF1_10445 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BTF1_10460 ENOG4108VJ1 Transcriptional regulator (CarD family BTF1_10515 ENOG4105KVH Transcriptional regulator BTF1_10525 ENOG4105C4W S-formylglutathione hydrolase BTF1_10535 ENOG4105D9M gamma-glutamylcysteine synthetase BTF1_10550 ENOG41082BM Transcriptional regulator, arsr family BTF1_10575 ENOG4105CVP deoxyribo-dipyrimidine photolyase BTF1_10580 ENOG4108606 TspO/MBR family BTF1_10595 ENOG4105WG9 Conserved Protein BTF1_10605 ENOG4105DQ6 Transposase BTF1_10615 ENOG4105ECP epimerase BTF1_10630 ENOG4105XZV Protein of unknown function (DUF3243) BTF1_10640 ENOG4105F6S Spore photoproduct lyase BTF1_10665 ENOG4108JJB ABC transporter BTF1_10680 ENOG4108HGU Histidine kinase BTF1_10775 ENOG4105CB2 alcohol dehydrogenase BTF1_10780 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BTF1_10785 ENOG4105CJN penicillin-binding protein BTF1_10830 ENOG4107Y80 Major Facilitator superfamily BTF1_10855 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BTF1_10885 ENOG4107Y9U Membrane BTF1_10905 ENOG4105EGD dinuclear metal center protein, YbgI family BTF1_10910 ENOG4105M6F mutator MutT protein BTF1_10930 ENOG4105FCD Major Facilitator BTF1_10945 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BTF1_10950 ENOG4108Z4K mutator MutT protein BTF1_10975 ENOG4108XI2 Domain of unknown function (DUF1963) BTF1_10995 ENOG4108NRW Phospholipase, patatin family BTF1_11000 ENOG4105KWG Pfam:DUF1696 BTF1_11030 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BTF1_11040 ENOG4105PKS Excinuclease abc c subunit domain protein BTF1_11075 ENOG41087PP glycosyltransferase MGT family BTF1_11080 ENOG41087PP glycosyltransferase MGT family BTF1_11095 ENOG4107VFR oxidoreductase BTF1_11120 ENOG4105U0R haloacid dehalogenase-like hydrolase BTF1_11125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_11130 ENOG4105BZU Histidine kinase BTF1_11150 ENOG4107WD8 ABC transporter, permease BTF1_11165 ENOG4105DY8 decarboxylase BTF1_11180 ENOG4108IUM Glycogen debranching enzyme BTF1_11190 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BTF1_11205 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BTF1_11210 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BTF1_11215 ENOG4105FDR Membrane BTF1_11220 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTF1_11270 ENOG4105MSI germination protein ypeb BTF1_11300 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BTF1_11305 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BTF1_11310 ENOG4107Z3H Transcriptional regulator, TetR family BTF1_11330 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BTF1_11350 ENOG4105E98 transcriptional regulator DeoR family BTF1_11365 ENOG41062ES Transcriptional regulator BTF1_11385 ENOG4107QKR Dehydrogenase BTF1_11395 ENOG4107RUY (E1 component), alpha subunit BTF1_11410 ENOG4105E1F short-chain dehydrogenase reductase BTF1_11415 ENOG4105RHY Pfam:UPF0157 BTF1_11450 ENOG4107SQ8 Glycine betaine BTF1_11455 ENOG4108IJ7 Glycine betaine BTF1_11465 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BTF1_11480 ENOG4105E66 phosphoriboisomerase A BTF1_11485 ENOG41082BV acetyltransferase BTF1_11505 ENOG4108M1A Chitin-binding protein BTF1_11510 ENOG41087PP glycosyltransferase MGT family BTF1_11520 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BTF1_11535 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTF1_11540 ENOG4105MSB protein, conserved in bacteria BTF1_11565 ENOG4108Z7F N-acetyltransferase BTF1_11590 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BTF1_11595 ENOG4105EEM helicase BTF1_11610 ENOG4105C9U ATP-dependent DNA helicase RecQ BTF1_11665 ENOG4108M1A Chitin-binding protein BTF1_11685 ENOG4105BZG amino acid carrier protein BTF1_11690 ENOG4105C26 Dehydrogenase BTF1_11695 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BTF1_11705 ENOG4105CTU Proline racemase BTF1_11710 ENOG41080HI glycine oxidase BTF1_11720 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BTF1_11760 ENOG4107T5V SNARE associated Golgi BTF1_11770 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BTF1_11785 ENOG4105DTQ mandelate racemase muconate lactonizing BTF1_11800 ENOG4107SET aldo keto reductase BTF1_11835 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BTF1_11840 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTF1_11845 ENOG4105BZU Histidine kinase BTF1_11850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_11875 ENOG4105DPN Oligoendopeptidase f BTF1_11880 ENOG4105EPR degv family BTF1_11940 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BTF1_11945 ENOG4106K7D Major facilitator family transporter BTF1_11965 ENOG4107BMA Transglycosylase associated protein BTF1_11980 ENOG41089UC methyltransferase, type 11 BTF1_12020 ENOG4105CHM Aminotransferase BTF1_12075 ENOG4105C02 permease BTF1_12095 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BTF1_12100 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BTF1_12105 ENOG4105D7T ABC transporter BTF1_12130 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BTF1_12165 ENOG4107VC0 DNA alkylation repair enzyme BTF1_12170 ENOG4105C6T cysteine synthase BTF1_12175 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BTF1_12190 ENOG4107VMI polysaccharide deacetylase BTF1_12210 ENOG4108ZCF integral membrane protein BTF1_12215 ENOG4105E0M Sulfatase BTF1_12220 ENOG4105C5H ABC transporter BTF1_12225 ENOG4105EYF MMPL domain protein BTF1_12230 ENOG41082JN Transcriptional regulator BTF1_12255 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BTF1_12260 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BTF1_12295 ENOG41069ER domain protein BTF1_12330 ENOG4105D4B ABC, transporter BTF1_12340 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BTF1_12350 ENOG4105DKT Transcriptional regulator BTF1_12355 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BTF1_12365 ENOG41061GT Aldolase BTF1_12380 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BTF1_12410 ENOG4105II7 pyrroline-5-carboxylate reductase BTF1_12420 ENOG4107258 Transcriptional regulator BTF1_12445 ENOG4105ECK Fatty Acid Desaturase BTF1_12455 ENOG4107RBI VanW family BTF1_12460 ENOG4105G6Z alkaline phosphatase BTF1_12470 ENOG4105VMP Transcriptional regulator BTF1_12490 ENOG41068WN BTF1_12520 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BTF1_12545 ENOG4105C8Y Acetylornithine aminotransferase BTF1_12575 ENOG41090AA BTF1_12580 ENOG4106BHF BTF1_12585 ENOG4108IBT Inherit from COG: transposase BTF1_12605 ENOG4108TVJ Nitroreductase BTF1_12610 ENOG4105FS7 Transcriptional regulator BTF1_12625 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BTF1_12630 ENOG4105WEC Molybdate metabolism regulator BTF1_12635 ENOG4105CMR udp-glucose 4-epimerase BTF1_12640 ENOG4105C19 ABC transporter BTF1_12670 ENOG4108XET gCN5-related N-acetyltransferase BTF1_12680 ENOG4105E09 nadh pyrophosphatase BTF1_12685 ENOG4108PCN EamA-like transporter family BTF1_12735 ENOG410635A Membrane BTF1_12745 ENOG4108IQI permease BTF1_12800 ENOG4108VJ1 Transcriptional regulator (CarD family BTF1_12820 ENOG4105BZU Histidine kinase BTF1_12845 ENOG4107RF6 penicillin-binding protein BTF1_12850 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BTF1_12880 ENOG4105P4J Allophanate hydrolase, subunit 1 BTF1_12885 ENOG4107258 Transcriptional regulator BTF1_12895 ENOG4106N3A copper homeostasis protein cutc BTF1_12900 ENOG4108ZHR arsR family transcriptional regulator BTF1_12910 ENOG4105FDT acyl-CoA dehydrogenase BTF1_12925 ENOG4105DWD nucleoside recognition domain protein BTF1_12965 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BTF1_12995 ENOG4105E2A Dehydrogenase BTF1_13005 ENOG4108IJ0 Aspartate ammonia-lyase BTF1_13020 ENOG4108IMY Transcriptional regulator BTF1_13035 ENOG4108B31 Spore germination protein BTF1_13045 ENOG4105BZU Histidine kinase BTF1_13070 ENOG41075H3 AraC family transcriptional regulator BTF1_13075 ENOG4105YWU small acid-soluble spore protein BTF1_13080 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BTF1_13085 ENOG4105CUB amino acid BTF1_13090 ENOG4105II7 pyrroline-5-carboxylate reductase BTF1_13095 ENOG4108NHD germination protein BTF1_13100 ENOG4108Q8B Spore germination protein BTF1_13140 ENOG4106A3M Cytochrome p-450 BTF1_13155 ENOG4105CGH 5'-nucleotidase BTF1_13170 ENOG4105CHJ isochorismatase hydrolase BTF1_13195 ENOG41090MY MarR family Transcriptional regulator BTF1_13215 ENOG4105F6J Alpha beta hydrolase fold BTF1_13230 ENOG4108606 TspO/MBR family BTF1_13235 ENOG4105CVP deoxyribo-dipyrimidine photolyase BTF1_13250 ENOG4108TWJ NADH dehydrogenase subunit 5 BTF1_13255 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BTF1_13260 ENOG4107VMI polysaccharide deacetylase BTF1_13270 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BTF1_13275 ENOG4105DSE periplasmic solute binding protein BTF1_13280 ENOG4105CC5 ABC transporter BTF1_13285 ENOG4105DIK (ABC) transporter BTF1_13305 ENOG4105D6J arsenicaL-resistance protein BTF1_13310 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BTF1_13315 ENOG41085FC arsR family transcriptional regulator BTF1_13330 ENOG4105EGI Transcriptional regulator BTF1_13370 ENOG4105VZ8 Transcriptional regulator BTF1_13380 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BTF1_13390 ENOG4107P5I polyketide synthase BTF1_13395 ENOG4108IG5 Transcriptional regulator BTF1_13400 ENOG4105CHR reductase BTF1_13405 ENOG4108YXU transcriptional regulator AsnC family BTF1_13445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_13450 ENOG4105BZU Histidine kinase BTF1_13485 ENOG4105DNP FAD linked oxidase domain protein BTF1_13495 ENOG4105C19 ABC transporter BTF1_13525 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BTF1_13530 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTF1_13540 ENOG4105K6H D-cysteine desulfhydrase BTF1_13560 ENOG4105JQZ Methyltransferase BTF1_13580 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BTF1_13600 ENOG4105BZU Histidine kinase BTF1_13615 ENOG4108U05 Transcriptional regulator BTF1_13620 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BTF1_13630 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BTF1_13660 ENOG4108JQ1 Dehydrogenase BTF1_13665 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BTF1_13680 ENOG41082W1 Cupin 2, conserved barrel domain protein BTF1_13685 ENOG410874W AraC family transcriptional regulator BTF1_13705 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTF1_13715 ENOG4108IG5 Transcriptional regulator BTF1_13830 ENOG4107EV6 Inherit from COG: YD repeat protein BTF1_13855 ENOG4108VXD carboxy-peptidase BTF1_13860 ENOG4105PNM synthesis protein BTF1_13870 ENOG4108ISG Major Facilitator BTF1_13885 ENOG4107MII Sugar-specific transcriptional regulator TrmB BTF1_13890 ENOG4105CZM Major Facilitator BTF1_13905 ENOG4105CRW Short chain fatty acid transporter BTF1_13915 ENOG4105DYS nad(p)h dehydrogenase (quinone) BTF1_13975 ENOG4108K8S endonuclease I BTF1_13985 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BTF1_13990 ENOG4108Z66 YbaK ebsC protein BTF1_14010 ENOG4105KVH Transcriptional regulator BTF1_14015 ENOG4108RCM Nitroreductase BTF1_14045 ENOG4108PSK reductase BTF1_14110 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BTF1_14115 ENOG4105DKQ ROK family BTF1_14120 ENOG4106UW1 Major Facilitator superfamily BTF1_14125 ENOG4108UW5 maltose o-acetyltransferase BTF1_14135 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BTF1_14145 ENOG4105C31 Tryptophanyl-tRNA synthetase BTF1_14185 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BTF1_14195 ENOG4105EV4 Multidrug resistance protein mdtH BTF1_14225 ENOG4105C37 (CBS) domain BTF1_14250 ENOG4105DDN Pentapeptide repeat-containing protein BTF1_14255 ENOG4105XDF Protein of unknown function (DUF1272) BTF1_14260 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BTF1_14265 ENOG4105CMG Carbohydrate kinase BTF1_14270 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BTF1_14280 ENOG4105CV1 Transketolase (EC 2.2.1.1) BTF1_14285 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BTF1_14300 ENOG4105C44 Serine transporter BTF1_14330 ENOG4105KVH Transcriptional regulator BTF1_14335 ENOG4108TZY GntR Family Transcriptional Regulator BTF1_14340 ENOG4105D9R oxidoreductase BTF1_14385 ENOG4105JAB phenazine biosynthesis protein, phzf family BTF1_14400 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BTF1_14405 ENOG4105KVH Transcriptional regulator BTF1_14415 ENOG4107SCK Monooxygenase BTF1_14430 ENOG4108ZJ4 polysaccharide deacetylase BTF1_14490 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BTF1_14525 ENOG4105H3G oxidoreductase BTF1_14560 ENOG4105CIS alcohol dehydrogenase BTF1_14595 ENOG4108TN2 lmbE family BTF1_14605 ENOG4107R3E Citrate transporter BTF1_14615 ENOG4105WCN acetyltransferase BTF1_14625 ENOG4105NX3 Membrane BTF1_14645 ENOG4107CUJ Protein of unknown function (DUF2690) BTF1_14655 ENOG4107V2S Transcriptional regulator BTF1_14675 ENOG4105C98 muts2 protein BTF1_14685 ENOG4105E5K Alpha-amylase BTF1_14690 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BTF1_14695 ENOG4105DPN Oligoendopeptidase f BTF1_14725 ENOG4108A04 Beta-lactamase BTF1_14755 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BTF1_14770 ENOG41082BM Transcriptional regulator, arsr family BTF1_14775 ENOG4105CIS alcohol dehydrogenase BTF1_14800 ENOG4105C09 Bile acid BTF1_14805 ENOG4105CQB FAD linked oxidase domain protein BTF1_14825 ENOG4105CEP NADH dehydrogenase BTF1_14845 ENOG4105CNI cell division protein FtsW BTF1_14860 ENOG4105D2T synthase BTF1_14875 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BTF1_14880 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BTF1_14885 ENOG4105C1B dTDP-glucose 4-6-dehydratase BTF1_14890 ENOG4105C5E polysaccharide biosynthesis protein BTF1_14915 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BTF1_14920 ENOG4108M1A Chitin-binding protein BTF1_14935 ENOG4105E1K spore germination protein BTF1_14955 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BTF1_14970 ENOG4105FAW cDP-glucose 4,6-dehydratase BTF1_15020 ENOG4105BZU Histidine kinase BTF1_15030 ENOG41067SE Tetr family transcriptional regulator BTF1_15095 ENOG4105XSJ toxin secretion phage lysis holin BTF1_15155 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BTF1_15165 ENOG4105CAR Terminase, large subunit BTF1_15325 ENOG4108IMY Transcriptional regulator BTF1_15355 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BTF1_15365 ENOG4108VXD carboxy-peptidase BTF1_15370 ENOG4107DUR UPF0457 protein BTF1_15390 ENOG4105BZU Histidine kinase BTF1_15400 ENOG4105KT7 mgtC SapB transporter BTF1_15410 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BTF1_15420 ENOG41073R8 VanW family BTF1_15430 ENOG4108R1P BTF1_15450 ENOG4105VEQ Cold shock protein BTF1_15470 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BTF1_15490 ENOG410904N short-chain dehydrogenase reductase BTF1_15500 ENOG4106IQC argininosuccinate lyase BTF1_15515 ENOG4108IA2 Sodium pantothenate symporter BTF1_15525 ENOG4105C26 Dehydrogenase BTF1_15530 ENOG4105CHR reductase BTF1_15540 ENOG4105EWU Squalene--hopene cyclase BTF1_15550 ENOG4105FR1 rard protein BTF1_15555 ENOG410696E Membrane BTF1_15570 ENOG4105D1F ATP-binding protein BTF1_15580 ENOG4108ZAF Molybdopterin BTF1_15585 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTF1_15590 ENOG4105D06 uba thif-type nad fad binding protein BTF1_15595 ENOG4105TMB Formate nitrite transporter BTF1_15605 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BTF1_15610 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BTF1_15620 ENOG4108JB9 formate dehydrogenase BTF1_15660 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BTF1_15760 ENOG4108C33 Resolvase BTF1_15785 ENOG4105WXW Antirepressor BTF1_15800 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTF1_15845 ENOG4108PNI recT protein BTF1_15850 ENOG4108NF7 phage-type endonuclease BTF1_15905 ENOG4108JB9 formate dehydrogenase BTF1_15985 ENOG4107QJT sodium dicarboxylate symporter BTF1_15990 ENOG4108KGH TRANSCRIPTIONal BTF1_16000 ENOG4105EMN RNA polymerase sigma factor BTF1_16010 ENOG4105CIG ABC transporter BTF1_16030 ENOG4105D9R oxidoreductase BTF1_16040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTF1_16045 ENOG4105K4P CoA-binding domain protein BTF1_16050 ENOG4105C0H protease BTF1_16055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_16065 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BTF1_16070 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BTF1_16075 ENOG4105W8X HesB YadR YfhF-family protein BTF1_16100 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BTF1_16105 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTF1_16115 ENOG4108JJB ABC transporter BTF1_16120 ENOG4108I0Z Aconitate hydratase BTF1_16150 ENOG4105E5W Transporter BTF1_16160 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTF1_16180 ENOG4107F3J Amp-dependent synthetase and ligase BTF1_16185 ENOG4107ZYJ bioY protein BTF1_16190 ENOG4105CEY Amp-dependent synthetase and ligase BTF1_16195 ENOG4108IMY Transcriptional regulator BTF1_16230 ENOG4107AYK membrAne BTF1_16240 ENOG4105BZU Histidine kinase BTF1_16245 ENOG4105FBA Phospholipase Carboxylesterase BTF1_16250 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BTF1_16255 ENOG4105CK7 Sodium proline symporter BTF1_16265 ENOG4105CBC glutamate synthase BTF1_16270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BTF1_16275 ENOG4108VJ1 Transcriptional regulator (CarD family BTF1_16280 ENOG4108903 Formimidoylglutamase BTF1_16335 ENOG4107QIV Cytochrome c biogenesis protein BTF1_16350 ENOG4105CH2 amidohydrolase BTF1_16360 ENOG4105CJ1 ABC, transporter BTF1_16380 ENOG4107RSM transcriptional regulator BTF1_16385 ENOG4105VAW lrga family BTF1_16390 ENOG41067MG lrgb family BTF1_16430 ENOG4105BZ1 (ABC) transporter BTF1_16435 ENOG4105BZ1 (ABC) transporter BTF1_16470 ENOG4108HW3 (ABC) transporter BTF1_16475 ENOG4105CGH 5'-nucleotidase BTF1_16485 ENOG4108SVB resolvase BTF1_16505 ENOG4105K7K Transcriptional regulator BTF1_16515 ENOG41065S2 pneumococcal vaccine antigen BTF1_16555 ENOG4105C5F glutamine synthetase BTF1_16560 ENOG4105KV4 Transcriptional regulator BTF1_16565 ENOG4105CXI aluminum resistance protein BTF1_16570 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BTF1_16575 ENOG4105EN6 Membrane BTF1_16585 ENOG4106F1P AAA ATPase, central domain protein BTF1_16620 ENOG41069ER domain protein BTF1_16625 ENOG4105DM4 PTS System BTF1_16630 ENOG4105DE4 1-phosphofructokinase BTF1_16635 ENOG4105E98 transcriptional regulator DeoR family BTF1_16640 ENOG4107QW4 alcohol dehydrogenase BTF1_16645 ENOG4108SJC Membrane BTF1_16660 ENOG4105C85 amino acid BTF1_16680 ENOG4105TMB Formate nitrite transporter BTF1_16685 ENOG4105K70 DNA-binding protein BTF1_16695 ENOG4105C59 p-type ATPase BTF1_16700 ENOG410681U heavy metal transport detoxification protein BTF1_16705 ENOG4105VPX protein, conserved in bacteria BTF1_16725 ENOG4105NIV Esterase BTF1_16730 ENOG4105E0A ABC, transporter BTF1_16750 ENOG4105CGK Exodeoxyribonuclease III BTF1_16760 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BTF1_16765 ENOG4105D03 DNA-3-methyladenine glycosylase II BTF1_16795 ENOG4105BZU Histidine kinase BTF1_16830 ENOG41067MG lrgb family BTF1_16855 ENOG4105C8Q Methyl-accepting chemotaxis BTF1_16860 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BTF1_16870 ENOG4105F0V Cell wall hydrolase BTF1_16880 ENOG4105E0M Sulfatase BTF1_16885 ENOG410890F Dynamin family BTF1_16920 ENOG4105DQU oxidoreductase, subunit beta BTF1_16925 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BTF1_16930 ENOG4108IGT Dipeptidase BTF1_16935 ENOG4105MCT stage V sporulation protein S BTF1_16940 ENOG4105D48 metallophosphoesterase BTF1_16960 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BTF1_16975 ENOG4105XZV Protein of unknown function (DUF3243) BTF1_16980 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BTF1_17000 ENOG4105UIB (ABC) transporter BTF1_17005 ENOG4108JQ9 ABC transporter BTF1_17010 ENOG4105DIH basic membrane BTF1_17015 ENOG4105FDP GntR family transcriptional regulator BTF1_17020 ENOG4105CNU cell division protein FtsK BTF1_17030 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BTF1_17040 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BTF1_17050 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BTF1_17055 ENOG4108S0H Dipicolinic acid synthetase, b subunit BTF1_17060 ENOG4108IBT Inherit from COG: transposase BTF1_17235 ENOG4105CDU Replicative dna helicase BTF1_17280 ENOG4108IMY Transcriptional regulator BTF1_17300 ENOG4108S0H Dipicolinic acid synthetase, b subunit BTF1_17305 ENOG4105E35 Dipicolinate synthase subunit A BTF1_17315 ENOG4105C1V Peptidase, M16 BTF1_17335 ENOG4105DTN riboflavin biosynthesis protein ribF BTF1_17350 ENOG4105W7A Protein of unknown function (DUF503) BTF1_17360 ENOG4105VHM ribosomal protein BTF1_17365 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BTF1_17370 ENOG4105CHV Transcription elongation factor NusA BTF1_17380 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BTF1_17390 ENOG4105DZP Membrane-associated zinc metalloprotease BTF1_17395 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BTF1_17400 ENOG4105KNE Phosphatidate cytidylyltransferase BTF1_17405 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BTF1_17415 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BTF1_17445 ENOG4108HE4 integrase family BTF1_17455 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BTF1_17460 ENOG4105C79 DNA protecting protein DprA BTF1_17465 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BTF1_17480 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BTF1_17505 ENOG4105VB6 UPF0109 protein BTF1_17525 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BTF1_17530 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BTF1_17545 ENOG4105CHR reductase BTF1_17550 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BTF1_17565 ENOG4105CB5 ATP-dependent DNA helicase recG BTF1_17570 ENOG4105DP4 dak2 domain fusion protein ylov BTF1_17575 ENOG4108ZAA Alkaline-shock protein BTF1_17590 ENOG4105FJ0 thiamine BTF1_17595 ENOG4105DJV ribulose-phosphate 3-epimerase BTF1_17600 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BTF1_17605 ENOG4105D9P serine threonine protein kinase BTF1_17610 ENOG4108ZF3 Phosphatase BTF1_17620 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BTF1_17635 ENOG4105C25 Primosomal protein n' BTF1_17640 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BTF1_17660 ENOG4105DSJ YicC domain protein BTF1_17670 ENOG4105F23 Fibronectin-binding protein BTF1_17675 ENOG4105DC7 peptidase M24 BTF1_17755 ENOG4105C34 Pseudouridine synthase BTF1_17770 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BTF1_17780 ENOG4105DBK s4 domain protein BTF1_17785 ENOG41067XK integral membrane protein BTF1_17795 ENOG4105DFA alanine racemase domain protein BTF1_17800 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BTF1_17805 ENOG4105WR5 sporulation protein, YlmC YmxH family BTF1_17815 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTF1_17825 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BTF1_17830 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BTF1_17845 ENOG4105D4A Cell wall formation (By similarity) BTF1_17850 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BTF1_17855 ENOG4105CNI cell division protein FtsW BTF1_17870 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BTF1_17875 ENOG4105CJN penicillin-binding protein BTF1_17880 ENOG4105CJN penicillin-binding protein BTF1_17920 ENOG4105KNH Nucleic acid-binding protein BTF1_17930 ENOG41063PX domain protein BTF1_17935 ENOG4105D78 K07001 NTE family protein BTF1_17940 ENOG4105H20 Sporulation integral membrane protein YlbJ BTF1_17950 ENOG4106H78 methyltransferase BTF1_17970 ENOG4107TB6 phosphoglycerate mutase BTF1_17985 ENOG4106UY4 Inherit from COG: Scp-like extracellular BTF1_18035 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BTF1_18040 ENOG4105CNI cell division protein FtsW BTF1_18055 ENOG4108IAB Phoh family BTF1_18075 ENOG4105QA2 BTF1_18080 ENOG4105CI3 gtp-binding protein typa BTF1_18090 ENOG4105ECY inositol monophosphatase BTF1_18110 ENOG4105CXN decarboxylase BTF1_18160 ENOG4105CPP Dehydrogenase, E1 component BTF1_18175 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BTF1_18180 ENOG4108X4Q Hydrolase BTF1_18190 ENOG4105CN5 Metallo-Beta-Lactamase BTF1_18195 ENOG4107ZYR domain protein BTF1_18230 ENOG4108XRC Protein of unknown function (DUF458) BTF1_18240 ENOG4107IN1 Protein of unknown function (DUF1797) BTF1_18255 ENOG4105EPM Diguanylate phosphodiesterase BTF1_18260 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BTF1_18275 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BTF1_18285 ENOG4105UIN BTF1_18340 ENOG4108HGU Histidine kinase BTF1_18350 ENOG4105CHM Aminotransferase BTF1_18355 ENOG4105FKQ transcriptional regulator BTF1_18360 ENOG4105EG2 ABC transporter, permease BTF1_18370 ENOG4107FKK extracellular solute-binding protein family 1 BTF1_18380 ENOG4105CG3 alpha amylase, catalytic region BTF1_18425 ENOG4105CHU acetyl-coa acetyltransferase BTF1_18460 ENOG4105K7K Transcriptional regulator BTF1_18465 ENOG4105DTD Dehydrogenase BTF1_18485 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BTF1_18510 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BTF1_18525 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BTF1_18535 ENOG4105BZU Histidine kinase BTF1_18555 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BTF1_18570 ENOG4105CID antiterminator BTF1_18580 ENOG4105FDP GntR family transcriptional regulator BTF1_18590 ENOG4105CE4 GlcNAc 6-P deacetylase BTF1_18625 ENOG4107ZE5 PPIases accelerate the folding of proteins BTF1_18630 ENOG4105PTM secreted protein BTF1_18635 ENOG4105J7I hydrolase BTF1_18645 ENOG4105G6R Stage v sporulation protein ae BTF1_18655 ENOG4105CZ3 stage V sporulation protein ad BTF1_18660 ENOG41090VF Stage v sporulation protein ac BTF1_18680 ENOG4105C8J )-transporter BTF1_18685 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTF1_18695 ENOG41082AN stage II sporulation protein BTF1_18700 ENOG4105DZ1 carboxypeptidase BTF1_18705 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BTF1_18710 ENOG4105DVE abc transporter atp-binding protein BTF1_18745 ENOG4105D7N magnesium and cobalt transport protein CorA BTF1_18770 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTF1_18780 ENOG4105I3K Ferric uptake regulator, Fur family BTF1_18785 ENOG4105MZ9 stage II sporulation protein m BTF1_18805 ENOG4105CPC Aldo Keto reductase BTF1_18815 ENOG4105RHY Pfam:UPF0157 BTF1_18835 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BTF1_18845 ENOG4105ETE Transcriptional regulator (LacI family BTF1_18850 ENOG4108YM7 Gcn5-related n-acetyltransferase BTF1_18870 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BTF1_18875 ENOG4108R6K riboflavin synthase, subunit alpha BTF1_18900 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTF1_18905 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTF1_18920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTF1_18930 ENOG4105DFD Na H antiporter BTF1_18935 ENOG4105CGH 5'-nucleotidase BTF1_18960 ENOG4105DBV ornithine carbamoyltransferase BTF1_18975 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BTF1_18990 ENOG4108IXY short-chain dehydrogenase reductase BTF1_18995 ENOG41069FQ Metallo-beta-lactamase superfamily BTF1_19000 ENOG4105II7 pyrroline-5-carboxylate reductase BTF1_19005 ENOG4105EJQ L-serine dehydratase BTF1_19035 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BTF1_19055 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BTF1_19060 ENOG4105D9U N-acetyltransferase BTF1_19075 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BTF1_19080 ENOG4108QEG Membrane BTF1_19085 ENOG4105CDA abc transporter atp-binding protein BTF1_19090 ENOG4105E5Q amino acid AbC transporter BTF1_19095 ENOG4108HW3 (ABC) transporter BTF1_19105 ENOG4105G7B Protein of unknown function (DUF2992) BTF1_19115 ENOG4108QY0 Membrane BTF1_19125 ENOG4105C7S Dehydrogenase BTF1_19130 ENOG4105CPP Dehydrogenase, E1 component BTF1_19150 ENOG4107RDP Dehydrogenase BTF1_19160 ENOG4108JUB Transcriptional regulator BTF1_19170 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BTF1_19205 ENOG4105DQ6 Transposase BTF1_19220 ENOG4108C33 Resolvase BTF1_19260 ENOG4107QQR Sporulation BTF1_19265 ENOG4105S1Z Stage IV sporulation protein B BTF1_19270 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BTF1_19275 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BTF1_19280 ENOG4105DX0 Hemolysin A BTF1_19290 ENOG4105CTB Polyprenyl synthetase BTF1_19315 ENOG4108ZSR alkaline shock protein BTF1_19320 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BTF1_19340 ENOG410644B Stage III sporulation protein af BTF1_19350 ENOG4105KQ4 Stage iii sporulation protein ad BTF1_19355 ENOG4108CQH stage III sporulation protein AC BTF1_19360 ENOG4105KR5 Stage iii sporulation protein BTF1_19365 ENOG4105CD2 stage iii sporulation protein aa BTF1_19390 ENOG4105DC7 peptidase M24 BTF1_19405 ENOG4105CBJ Metal-dependent enzyme BTF1_19415 ENOG4107YBY Hydrolase BTF1_19445 ENOG41082GG biotin lipoate A B protein ligase BTF1_19450 ENOG4105WZW rhodanese family BTF1_19475 ENOG41080TC multidrug resistance protein BTF1_19515 ENOG4105C0D helicase BTF1_19545 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BTF1_19600 ENOG4107R6U sodium dicarboxylate symporter BTF1_19635 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BTF1_19640 ENOG4105C3R Methionine synthase BTF1_19650 ENOG4105C28 cystathionine BTF1_19655 ENOG4105C28 cystathionine BTF1_19680 ENOG4105C5X domain protein BTF1_19690 ENOG4105DKQ ROK family BTF1_19700 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BTF1_19715 ENOG4108UTW Plays a role in the regulation of phosphate uptake BTF1_19720 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BTF1_19725 ENOG4105C8U phosphate abc transporter BTF1_19730 ENOG4105C8U phosphate abc transporter BTF1_19740 ENOG4107RF6 penicillin-binding protein BTF1_19780 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BTF1_19875 ENOG4108C33 Resolvase BTF1_19955 ENOG4108IMY Transcriptional regulator BTF1_19985 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTF1_20010 ENOG4105N80 Ferric uptake regulator, Fur family BTF1_20020 ENOG4105FDK ABC transporter BTF1_20025 ENOG4108JYZ YitT family BTF1_20030 ENOG41069ZM Protein of unknown function (DUF2624) BTF1_20055 ENOG4105EGD dinuclear metal center protein, YbgI family BTF1_20070 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTF1_20075 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BTF1_20080 ENOG4107XJU UPF0178 protein BTF1_20085 ENOG4107XJU UPF0178 protein BTF1_20110 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BTF1_20115 ENOG4105KG3 cytidine deaminase BTF1_20120 ENOG4107YR5 Diacylglycerol kinase BTF1_20130 ENOG4105CTJ Metal Dependent Phosphohydrolase BTF1_20135 ENOG4105C9A Phoh family BTF1_20145 ENOG41068P3 sporulation protein YqfC BTF1_20155 ENOG4105KTH gatB Yqey BTF1_20165 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BTF1_20170 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BTF1_20200 ENOG4105CSA Coproporphyrinogen iii oxidase BTF1_20205 ENOG4105KVH Transcriptional regulator BTF1_20230 ENOG4105TQK DNA polymerase iii, delta' subunit BTF1_20240 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BTF1_20245 ENOG4108UK2 deaminase BTF1_20250 ENOG4105KQC Competence protein BTF1_20260 ENOG4105DXX methyltransferase BTF1_20270 ENOG4108WF2 Metal Dependent Phosphohydrolase BTF1_20280 ENOG410812S Rna-binding protein BTF1_20290 ENOG4105CQW ribosome biogenesis GTPase YqeH BTF1_20295 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BTF1_20310 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTF1_20330 ENOG4108TVJ Nitroreductase BTF1_20340 ENOG4105G6Z alkaline phosphatase BTF1_20345 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BTF1_20350 ENOG4108MUZ hydrolase BTF1_20385 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BTF1_20395 ENOG4105MIR Phenylalanine 4-monooxygenase BTF1_20405 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BTF1_20445 ENOG4105S6R Iron-hydroxamate transporter permease subunit BTF1_20450 ENOG4108V5C ABC transporter BTF1_20460 ENOG4108EKI Dehydrogenase BTF1_20465 ENOG4105C28 cystathionine BTF1_20495 ENOG4107XRG penicillin-binding protein BTF1_20505 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BTF1_20515 ENOG4105CFP Peptidase U32 BTF1_20520 ENOG4105XYU peptidase (U32 family) BTF1_20525 ENOG4108VQJ O-methyltransferase BTF1_20530 ENOG4105HHA aminodeoxychorismate lyase BTF1_20550 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTF1_20560 ENOG4105C02 permease BTF1_20575 ENOG41060CR BTF1_20580 ENOG4105C7H Helicase, RecD TraA family BTF1_20590 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BTF1_20595 ENOG4105C3J Cysteine desulfurase BTF1_20605 ENOG4105D1H recombination factor protein RarA BTF1_20610 ENOG4108VCI transcription factor, rsfa family BTF1_20615 ENOG4105CUZ uba thif-type nad fad binding protein BTF1_20625 ENOG4105CUT histidyl-tRNA synthetase BTF1_20645 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BTF1_20655 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BTF1_20660 ENOG41076HS cation diffusion facilitator family transporter BTF1_20665 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BTF1_20675 ENOG4105CKP Polysaccharide Biosynthesis Protein BTF1_20680 ENOG4108QG2 Membrane BTF1_20690 ENOG4105VIE preprotein translocase, subunit YajC BTF1_20705 ENOG41061AI Protein of unknown function (DUF2905) BTF1_20720 ENOG4108HUF Transporter BTF1_20750 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BTF1_20755 ENOG4108IYU L-aspartate oxidase BTF1_20770 ENOG4108RPX mosc domain containing protein BTF1_20780 ENOG4105CQC Prephenate dehydratase BTF1_20800 ENOG4105EWM Histidine kinase BTF1_20825 ENOG4105X36 (ribosomal) protein BTF1_20835 ENOG4105C03 ribonuclease BTF1_20850 ENOG4107QMS site-determining protein BTF1_20865 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BTF1_20870 ENOG4105DFF Rod shape-determining protein mreb BTF1_20890 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BTF1_20895 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BTF1_20905 ENOG41068KH stage VI sporulation protein D BTF1_20915 ENOG4105D52 delta-aminolevulinic acid dehydratase BTF1_20940 ENOG4105K56 Transcriptional regulator BTF1_20960 ENOG4108IUQ atp-dependent protease BTF1_20985 ENOG4108QCI YvbH-like oligomerisation region BTF1_20995 ENOG4105DQ6 Transposase BTF1_21005 ENOG4105M59 Phosphodiesterase, mj0936 family BTF1_21020 ENOG4108XJQ germination protein BTF1_21030 ENOG4108PCX Major Facilitator BTF1_21040 ENOG4105KBX Transcriptional regulator, TetR family BTF1_21050 ENOG4105PFC Transcriptional regulator BTF1_21060 ENOG4105DZC cytosine deaminase BTF1_21065 ENOG41067S9 phage shock protein C, PspC BTF1_21070 ENOG4108JCI Transcriptional regulator BTF1_21080 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BTF1_21085 ENOG4108Z40 Transcriptional regulator BTF1_21090 ENOG4105RHA ABC transporter, permease BTF1_21095 ENOG4108IUX (ABC) transporter BTF1_21100 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BTF1_21105 ENOG4105ER2 Ompa motb domain protein BTF1_21110 ENOG4105E14 MotA TolQ exbB proton channel BTF1_21115 ENOG4108VXD carboxy-peptidase BTF1_21125 ENOG4105E33 succinate dehydrogenase BTF1_21135 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BTF1_21150 ENOG4105K63 Thioredoxin BTF1_21155 ENOG4105C10 Electron transfer flavoprotein BTF1_21160 ENOG4105BZJ Electron transfer flavoprotein BTF1_21165 ENOG41060WC Enoyl-CoA hydratase BTF1_21170 ENOG4107Z3H Transcriptional regulator, TetR family BTF1_21175 ENOG4105CEY Amp-dependent synthetase and ligase BTF1_21185 ENOG4105J76 Periplasmic binding protein BTF1_21190 ENOG4105S6R Iron-hydroxamate transporter permease subunit BTF1_21230 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTF1_21245 ENOG4105DR4 Methyltransferase BTF1_21255 ENOG4105KFN sortase, SrtB family BTF1_21260 ENOG4105E0A ABC, transporter BTF1_21275 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BTF1_21285 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BTF1_21295 ENOG4105FE9 pseudouridine synthase BTF1_21310 ENOG4105DCG PHP domain protein BTF1_21325 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BTF1_21340 ENOG4105C5S asparaginyl-tRNA synthetase BTF1_21345 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BTF1_21355 ENOG4108RWN rrna methyltransferase BTF1_21380 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTF1_21385 ENOG4105CW7 secretion protein, HlyD family BTF1_21390 ENOG4108JGH Tetr family transcriptional regulator BTF1_21395 ENOG4105CN9 Peptidase m42 family protein BTF1_21415 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BTF1_21420 ENOG4105C22 threonyL-tRNA synthetase BTF1_21425 ENOG4108TDW sporulation protein YtxC BTF1_21450 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BTF1_21455 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BTF1_21460 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BTF1_21470 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BTF1_21475 ENOG4105C2M dna polymerase I BTF1_21480 ENOG4105BZU Histidine kinase BTF1_21485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTF1_21510 ENOG4108HMX isocitrate dehydrogenase (NADP) BTF1_21515 ENOG4105BZN citrate synthase BTF1_21525 ENOG4108REF Sporulation integral membrane protein ytvi BTF1_21530 ENOG4105FS0 cytoplasmic membrane protein BTF1_21555 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BTF1_21560 ENOG4105C6K Malic enzyme BTF1_21565 ENOG4105C0B DNA polymerase III (alpha subunit) BTF1_21570 ENOG4105VV2 BTF1_21580 ENOG4105SFS phosphoesterase RecJ domain protein BTF1_21610 ENOG4105DC7 peptidase M24 BTF1_21645 ENOG4105Z7P Acetyltransferase (GNAT) family BTF1_21650 ENOG41082W1 Cupin 2, conserved barrel domain protein BTF1_21670 ENOG4107YZX Universal stress protein BTF1_21715 ENOG4108JYZ YitT family BTF1_21735 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BTF1_21745 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BTF1_21750 ENOG4105KBJ sporulation protein ytfj BTF1_21765 ENOG4105EFZ amidohydrolase BTF1_21775 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BTF1_21800 ENOG4107RSM transcriptional regulator BTF1_21810 ENOG4105U5Y Transcriptional regulator BTF1_21820 ENOG4105C28 cystathionine BTF1_21845 ENOG4108UW5 maltose o-acetyltransferase BTF1_21855 ENOG4105F1V Acetoin utilization protein BTF1_21860 ENOG4105W87 Cbs domain BTF1_21865 ENOG4105DGU Histone deacetylase BTF1_21880 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTF1_21885 ENOG4105BZU Histidine kinase BTF1_21890 ENOG4107SNB ankyrin repeat protein YahD BTF1_21895 ENOG4105EP9 oxidoreductase BTF1_21930 ENOG4105ETE Transcriptional regulator (LacI family BTF1_21935 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BTF1_21940 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BTF1_21945 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BTF1_21965 ENOG4105C88 aminopeptidase BTF1_21985 ENOG4108IPJ Membrane BTF1_22020 ENOG4108VDD TRNA binding domain protein BTF1_22050 ENOG4105C8F Beta-lactamase domain protein BTF1_22065 ENOG4108V15 phosphotransferase enzyme family BTF1_22070 ENOG4108IUM Glycogen debranching enzyme BTF1_22080 ENOG4107QSE Dipeptidase BTF1_22085 ENOG4105YW5 deoR family transcriptional regulator BTF1_22100 ENOG4105CBX hi0933 family BTF1_22135 ENOG4108VJ1 Transcriptional regulator (CarD family BTF1_22140 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BTF1_22145 ENOG4105CSC Glucose uptake protein BTF1_22160 ENOG4108ZAF Molybdopterin BTF1_22165 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BTF1_22170 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTF1_22180 ENOG4105D06 uba thif-type nad fad binding protein BTF1_22185 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BTF1_22205 ENOG41085GJ domain protein BTF1_22215 ENOG4105DWV Homoserine O-trans-acetylase BTF1_22255 ENOG410605W Major Facilitator BTF1_22260 ENOG4107S91 Sodium hydrogen exchanger BTF1_22265 ENOG4105NCW Trka-c domain protein BTF1_22280 ENOG4105C19 ABC transporter BTF1_22300 ENOG4105N5T Radical SAM Protein BTF1_22325 ENOG4105E8V Alpha Beta Hydrolase Fold protein BTF1_22330 ENOG4108Z0R Transferase BTF1_22335 ENOG4105YVM Phosphoesterase, PA-phosphatase related BTF1_22340 ENOG4105BZF Glycosyl transferase (Group 1 BTF1_22350 ENOG4105EPU Molybdenum cofactor synthesis domain protein BTF1_22430 ENOG4105BZU Histidine kinase BTF1_22435 ENOG4105BZU Histidine kinase BTF1_22440 ENOG4105CH6 catalase BTF1_22445 ENOG4107S9D Alpha beta hydrolase BTF1_22450 ENOG4107T7U Sulfatase BTF1_22475 ENOG4105D2X ABC transporter substrate-binding protein BTF1_22485 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BTF1_22540 ENOG41080TC multidrug resistance protein BTF1_22545 ENOG410839T multidrug resistance protein BTF1_22565 ENOG4108V2W Carbonate dehydratase BTF1_22570 ENOG4105C4M (Ubiquinol oxidase) subunit I BTF1_22575 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BTF1_22620 ENOG41087YS Phage shock protein A BTF1_22645 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BTF1_22650 ENOG4105BZU Histidine kinase BTF1_22655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_22680 ENOG4108UGV hypoxanthine phosphoribosyltransferase BTF1_22685 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BTF1_22745 ENOG4105BZU Histidine kinase BTF1_22755 ENOG4107ZTW SNARE associated Golgi BTF1_22770 ENOG4105C19 ABC transporter BTF1_22775 ENOG41086D8 Transcriptional regulator BTF1_22785 ENOG4105CJ1 ABC, transporter BTF1_22795 ENOG41082BM Transcriptional regulator, arsr family BTF1_22840 ENOG4105C6Z Gluconate BTF1_22845 ENOG4105FDP GntR family transcriptional regulator BTF1_22865 ENOG41069H0 dihydroorotase EC 3.5.2.3 BTF1_22885 ENOG4105DTQ mandelate racemase muconate lactonizing BTF1_22895 ENOG4108IPT Naphthoate synthase BTF1_22900 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BTF1_22910 ENOG4105E4F Isochorismate synthase BTF1_22915 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BTF1_22925 ENOG4105VEQ Cold shock protein BTF1_22970 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BTF1_22990 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BTF1_22995 ENOG4108Q5F Tetr family transcriptional regulator BTF1_23005 ENOG4105KT7 mgtC SapB transporter BTF1_23010 ENOG4107PBV potassium channel BTF1_23025 ENOG4105WG9 Conserved Protein BTF1_23035 ENOG4105CHM Aminotransferase BTF1_23040 ENOG4108ZB6 transcriptional regulator AsnC family BTF1_23045 ENOG4105C5I Dehydrogenase BTF1_23050 ENOG4108MUZ hydrolase BTF1_23060 ENOG4105C87 Aminotransferase class I and II BTF1_23075 ENOG4105Y38 Kinase-associated protein B BTF1_23085 ENOG4107R3E Citrate transporter BTF1_23100 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BTF1_23105 ENOG4105KA0 thioesterase Superfamily protein BTF1_23120 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BTF1_23140 ENOG41069ER domain protein BTF1_23155 ENOG4105CEP NADH dehydrogenase BTF1_23180 ENOG4105EWC Purine nucleoside phosphorylase BTF1_23210 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BTF1_23235 ENOG4108JJA ABC, transporter BTF1_23240 ENOG4105C4B ABC transporter, permease BTF1_23245 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BTF1_23300 ENOG41083MR nifu domain-containing protein BTF1_23315 ENOG4108W5N phosphatidylglycerophosphatase a BTF1_23335 ENOG4105DAX Pfam:DUF2983 BTF1_23345 ENOG4105DYS nad(p)h dehydrogenase (quinone) BTF1_23350 ENOG4105D4U had-superfamily hydrolase, subfamily iia BTF1_23365 ENOG4105CBT Fructose-1,6-bisphosphatase BTF1_23380 ENOG4105MMD transcriptional regulator BTF1_23385 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BTF1_23390 ENOG4107TXC Transcriptional regulator BTF1_23395 ENOG41090T1 Membrane BTF1_23420 ENOG4105FAA peptidase M23 BTF1_23425 ENOG4108YTE sporulation protein YunB BTF1_23430 ENOG4105KZD Domain of unknown function (DUF1805) BTF1_23435 ENOG4107R8B 5'-nucleotidase BTF1_23440 ENOG4105DIW FeS assembly protein SUFB BTF1_23445 ENOG4108UNV SUF system FeS assembly protein, NifU family BTF1_23450 ENOG4105C9B Cysteine desulfurase BTF1_23455 ENOG4105JRK feS assembly protein SufD BTF1_23460 ENOG4105C3K feS assembly ATPase SufC BTF1_23465 ENOG4105D01 (LipO)protein BTF1_23470 ENOG4105D01 (LipO)protein BTF1_23475 ENOG4108UMI ABC transporter, permease BTF1_23480 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTF1_23505 ENOG41080E8 Transcriptional regulator, Spx MgsR family BTF1_23525 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BTF1_23540 ENOG4108W8B Beta-lactamase domain protein BTF1_23545 ENOG4105C1G acyl-Coa dehydrogenase BTF1_23555 ENOG4105CHU acetyl-coa acetyltransferase BTF1_23570 ENOG4105DZ1 carboxypeptidase BTF1_23590 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTF1_23605 ENOG4108SUT Major Facilitator Superfamily BTF1_23610 ENOG4107R7I amino acid BTF1_23625 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BTF1_23635 ENOG4107AYK membrAne BTF1_23670 ENOG4107ZTW SNARE associated Golgi BTF1_23680 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BTF1_23685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_23690 ENOG4105BZU Histidine kinase BTF1_23715 ENOG4105C8Q Methyl-accepting chemotaxis BTF1_23720 ENOG4105C8Q Methyl-accepting chemotaxis BTF1_23725 ENOG4105VG1 fes assembly suf system protein BTF1_23735 ENOG4105DQ6 Transposase BTF1_23740 ENOG4105D4Y metalloprotease BTF1_23745 ENOG4105C2I pirin domain protein BTF1_23760 ENOG4107T5V SNARE associated Golgi BTF1_23765 ENOG4107S91 Sodium hydrogen exchanger BTF1_23770 ENOG4105NCW Trka-c domain protein BTF1_23785 ENOG4108RMU ferritin dps family protein BTF1_23800 ENOG4108URH decarboxylase BTF1_23810 ENOG41090A1 ferritin BTF1_23820 ENOG4105D9N nucleoside BTF1_23825 ENOG4105D9N nucleoside BTF1_23840 ENOG4108RYK Nad-dependent epimerase dehydratase BTF1_23855 ENOG4105CV8 reductase BTF1_23860 ENOG4105F27 Major Facilitator BTF1_23865 ENOG4105KVH Transcriptional regulator BTF1_23880 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BTF1_23885 ENOG4105D4A Cell wall formation (By similarity) BTF1_23895 ENOG4105C8Q Methyl-accepting chemotaxis BTF1_23910 ENOG4105WMR Protein CrcB homolog BTF1_23930 ENOG4105C5H ABC transporter BTF1_23935 ENOG4108MK9 spermidine N(1)-acetyltransferase BTF1_23945 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BTF1_23955 ENOG4108W2Y isochorismatase BTF1_23975 ENOG4108V2W Carbonate dehydratase BTF1_23980 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) BTF1_24000 ENOG4108IPW abc transporter atp-binding protein BTF1_24005 ENOG4105CM4 permease protein BTF1_24030 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BTF1_24040 ENOG4105XZU Preprotein translocase, subunit SecG BTF1_24045 ENOG41067MG lrgb family BTF1_24095 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTF1_24110 ENOG41090VF Stage v sporulation protein ac BTF1_24115 ENOG4105CZ3 stage V sporulation protein ad BTF1_24130 ENOG4108QY0 Membrane BTF1_24135 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BTF1_24140 ENOG4105KRI phosphocarrier protein (HPr BTF1_24150 ENOG4105CHW UPF0052 protein BTF1_24160 ENOG4108Z4K mutator MutT protein BTF1_24170 ENOG4105C3M thioredoxin reductase BTF1_24180 ENOG4108S4C acetyltransferase BTF1_24200 ENOG41086DT Membrane protein of unknown function BTF1_24215 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BTF1_24235 ENOG4107TXC Transcriptional regulator BTF1_24250 ENOG4105HMI Membrane BTF1_24255 ENOG4105DUM transcriptional regulator, lysR family BTF1_24265 ENOG4108WS4 fmn reductase BTF1_24270 ENOG4105C5H ABC transporter BTF1_24280 ENOG4105BZ1 (ABC) transporter BTF1_24290 ENOG4105CN1 protease BTF1_24295 ENOG4105CRP Part of the ABC transporter FtsEX involved in BTF1_24300 ENOG4105CAK Cell division ATP-binding protein ftsE BTF1_24330 ENOG4105MS2 ribosomal subunit Interface protein BTF1_24335 ENOG4105VEQ Cold shock protein BTF1_24340 ENOG41081UC Inherit from COG: Competence protein BTF1_24355 ENOG4105KVH Transcriptional regulator BTF1_24365 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BTF1_24370 ENOG4108KGH TRANSCRIPTIONal BTF1_24375 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BTF1_24380 ENOG4105C6Y Udp-glucose 6-dehydrogenase BTF1_24385 ENOG4105ESV Glycosyl transferase, family 4 BTF1_24395 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BTF1_24415 ENOG4105F8D glycoside hydrolase family 4 BTF1_24420 ENOG4105VCP PTS System BTF1_24425 ENOG4105CK1 PTS System BTF1_24435 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BTF1_24440 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BTF1_24445 ENOG4105VCP PTS System BTF1_24455 ENOG4105VZJ PTS System BTF1_24475 ENOG4105ECB domain protein BTF1_24480 ENOG4107RSM transcriptional regulator BTF1_24515 ENOG4105DAA L-lactate BTF1_24525 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BTF1_24535 ENOG4105E0M Sulfatase BTF1_24565 ENOG4107R8N Glycosyl transferase, family 2 BTF1_24575 ENOG4105C94 Transporter BTF1_24580 ENOG41069ER domain protein BTF1_24605 ENOG4105KBK Zinc finger, swim domain protein BTF1_24610 ENOG4105C0D helicase BTF1_24640 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTF1_24650 ENOG4107RBB ABC transporter, permease BTF1_24655 ENOG4105C19 ABC transporter BTF1_24675 ENOG4105CXY transporter BTF1_24690 ENOG4105BZU Histidine kinase BTF1_24695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_24705 ENOG4108KGH TRANSCRIPTIONal BTF1_24710 ENOG4105CMR udp-glucose 4-epimerase BTF1_24715 ENOG4105C6Y Udp-glucose 6-dehydrogenase BTF1_24725 ENOG4105CPK Glycosyl transferase (Group 1 BTF1_24740 ENOG4105D3Q Sugar transferase BTF1_24745 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BTF1_24750 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BTF1_24755 ENOG4107YJ4 chain length determinant protein BTF1_24760 ENOG4105HTX biosynthesis protein BTF1_24765 ENOG4107YJ4 chain length determinant protein BTF1_24780 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BTF1_24790 ENOG4105FRN stage II sporulation protein BTF1_24805 ENOG4105DY9 regulatoR BTF1_24825 ENOG4106778 Protein of unknown function (DUF1146) BTF1_24830 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BTF1_24835 ENOG4105C8S subunit m BTF1_24840 ENOG4105D65 subunit l BTF1_24865 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BTF1_24870 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BTF1_24880 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BTF1_24885 ENOG4105BZU Histidine kinase BTF1_24935 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BTF1_24940 ENOG41062M3 atp synthase BTF1_24965 ENOG4108UIC UPF0340 protein BTF1_24970 ENOG4108YZG isomerase BTF1_24985 ENOG4108VGI doxx family BTF1_24990 ENOG4107XC4 flavin reductase domain protein, FMN-binding BTF1_25000 ENOG4105DQ6 Transposase BTF1_25025 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BTF1_25035 ENOG4108ZXQ stage ii sporulation protein r BTF1_25040 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BTF1_25045 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BTF1_25060 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BTF1_25065 ENOG4105CBT Fructose-1,6-bisphosphatase BTF1_25075 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BTF1_25110 ENOG4105C1G acyl-Coa dehydrogenase BTF1_25115 ENOG4105C1G acyl-Coa dehydrogenase BTF1_25120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BTF1_25130 ENOG4105DF6 Fe-S oxidoreductase BTF1_25135 ENOG41067QW Transcriptional regulator BTF1_25175 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BTF1_25180 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) BTF1_25235 ENOG4105BZU Histidine kinase BTF1_25250 ENOG4105D4Y metalloprotease BTF1_25260 ENOG4105BZU Histidine kinase BTF1_25265 ENOG4105KCT ABC transporter BTF1_25270 ENOG4108M15 ABC transporter BTF1_25275 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BTF1_25285 ENOG4105IIU Aminopeptidase BTF1_25300 ENOG4105EMN RNA polymerase sigma factor BTF1_25310 ENOG410684U Domain of unknown function (DUF1934) BTF1_25330 ENOG4105CYW agmatinase BTF1_25340 ENOG4105DXB Major Facilitator superfamily BTF1_25345 ENOG4107SWG transcriptional regulator MERR family BTF1_25355 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BTF1_25360 ENOG4105BZ4 penicillin-binding protein BTF1_25365 ENOG4108XFG YwhD family BTF1_25370 ENOG4108Z4T Peptidase M50 BTF1_25375 ENOG41069HH 4-oxalocrotonate tautomerase BTF1_25380 ENOG4105DCI Phosphohydrolase BTF1_25385 ENOG4108MES Periplasmic binding protein BTF1_25390 ENOG4105E0A ABC, transporter BTF1_25395 ENOG4105EHG Permease protein BTF1_25400 ENOG4105DQ5 transport system permease protein BTF1_25410 ENOG4108VCI transcription factor, rsfa family BTF1_25415 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BTF1_25420 ENOG4108IJ2 phosphate acetyltransferase BTF1_25425 ENOG4107UEZ chlorite dismutase BTF1_25435 ENOG4108VKI Cell wall hydrolase BTF1_25455 ENOG4107SVH Potassium channel protein BTF1_25465 ENOG410667J hydrolase BTF1_25470 ENOG4105VCH membrane BTF1_25480 ENOG4108TU7 Inherit from COG: (ABC) transporter BTF1_25485 ENOG4105CJ1 ABC, transporter BTF1_25490 ENOG41090WU lipolytic protein G-D-S-L family BTF1_25505 ENOG4105D6E homoserine dehydrogenase BTF1_25530 ENOG4108Y4K DNA-binding transcriptional activator BTF1_25540 ENOG4105WH1 Two component transcriptional regulator luxr family BTF1_25545 ENOG4105BZU Histidine kinase BTF1_25550 ENOG4105DWF phosphomethylpyrimidine kinase BTF1_25555 ENOG4105BZU Histidine kinase BTF1_25560 ENOG4105VCD cytoplasmic protein BTF1_25565 ENOG4105D22 carbon starvation protein BTF1_25570 ENOG4105DY9 regulatoR BTF1_25575 ENOG41079KZ Major Facilitator Superfamily BTF1_25585 ENOG4105CG5 Glycosyl transferase (Group 1 BTF1_25595 ENOG4105EN6 Membrane BTF1_25600 ENOG4106YBV Methyl-accepting chemotaxis BTF1_25610 ENOG4108S4H thioesterase Superfamily protein BTF1_25615 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BTF1_25630 ENOG4105K64 Glycosyl transferase, family 2 BTF1_25640 ENOG4105EJV Membrane BTF1_25645 ENOG4105CKK Glycosyl transferase, family 2 BTF1_25655 ENOG4108IG5 Transcriptional regulator BTF1_25660 ENOG4105C5H ABC transporter BTF1_25665 ENOG41067SE Tetr family transcriptional regulator BTF1_25675 ENOG4105E0X reductase BTF1_25680 ENOG4106F5Q Membrane BTF1_25695 ENOG4108NEV two component transcriptional regulator, LytTR family BTF1_25700 ENOG4108HRK Histidine kinase BTF1_25705 ENOG4107RGD Major Facilitator superfamily BTF1_25720 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTF1_25730 ENOG4105IW1 AmiS UreI transporter BTF1_25745 ENOG4105CMR udp-glucose 4-epimerase BTF1_25750 ENOG4108UT2 hemolysin iii BTF1_25760 ENOG4105C1J atp-dependent rna helicase BTF1_25765 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BTF1_25770 ENOG4105DPN Oligoendopeptidase f BTF1_25785 ENOG4105DQ6 Transposase BTF1_25795 ENOG4107Y5K Resolvase BTF1_25850 ENOG4107Y5K Resolvase BTF1_25855 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BTF1_25900 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BTF1_25915 ENOG4105C0H protease BTF1_25920 ENOG4105Q2H domain protein BTF1_25935 ENOG4105BZU Histidine kinase BTF1_25940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTF1_25945 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BTF1_25950 ENOG4105CDU Replicative dna helicase BTF1_25960 ENOG4105BZR domain protein BTF1_25965 ENOG4108XMW Membrane BTF1_25975 ENOG4108UUM single-stranded DNA-binding protein BTF1_25985 ENOG4105C3G gtp-binding protein BTF1_25990 ENOG4105VDK protein, conserved in bacteria BTF1_25995 ENOG4105D8X mechanosensitive ion channel BTF1_26000 ENOG4108ZDA Sporulation protein YyaC BTF1_26005 ENOG4105FA0 parb-like partition protein BTF1_26010 ENOG4107QJE Chromosome Partitioning Protein BTF1_26030 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BTF1_26040 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BTF1_26060 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BTF1_26065 ENOG410848D S4 domain protein YaaA BTF1_26080 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTF1_26090 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BTF1_26120 ENOG4105ZMH deoxynucleoside kinase BTF1_26130 ENOG4105GTG Isochorismatase BTF1_26135 ENOG4108Z6B deaminase BTF1_26140 ENOG4105C6E dna polymerase iii BTF1_26160 ENOG41067KS pro-sigma K processing BTF1_26170 ENOG4105CXN decarboxylase BTF1_26180 ENOG4105FA2 dna polymerase iii BTF1_26185 ENOG4105MA4 psp1 domain protein BTF1_26195 ENOG41060K3 Methyltransferase BTF1_26205 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BTF1_26210 ENOG4105KRN Transcriptional regulator, abrb family BTF1_26215 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BTF1_26220 ENOG4105F8V Hydrolase, tatD family BTF1_26225 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BTF1_26235 ENOG4105XFA sporulation peptidase YabG BTF1_26240 ENOG4105W42 Veg protein BTF1_26255 ENOG4105DFT pur operon repressor BTF1_26260 ENOG4105KME endoribonuclease L-psp BTF1_26275 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BTF1_26280 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BTF1_26290 ENOG4108JA2 transcriptioN-repair coupling factor BTF1_26295 ENOG4108M14 stage v sporulation protein t BTF1_26305 ENOG4108IY2 MazG family BTF1_26310 ENOG41082I2 s4 domain protein BTF1_26315 ENOG4105VYY sporulation protein yabp BTF1_26330 ENOG41060GV RNA binding s1 domain protein BTF1_26340 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BTF1_26345 ENOG4108UGV hypoxanthine phosphoribosyltransferase BTF1_26350 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BTF1_26365 ENOG4105C6T cysteine synthase BTF1_26370 ENOG4105CRQ synthase (Component I) BTF1_26375 ENOG4105DDQ anthranilate synthase BTF1_26380 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BTF1_26385 ENOG4105EEI dihydropteroate synthase BTF1_26390 ENOG4105KRF dihydroneopterin aldolase BTF1_26395 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BTF1_26405 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BTF1_26420 ENOG4108Z0C Uvrb UvrC protein BTF1_26435 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BTF1_26445 ENOG4105CTP PilT protein domain protein BTF1_26465 ENOG4105D7W serine acetyltransferase BTF1_26480 ENOG4105C2N RNA methyltransferase TrmH family group 3 BTF1_26485 ENOG4105M0M Tetracycline resistance protein BTF1_26490 ENOG4105QIV RNA polymerase BTF1_26505 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BTF1_26535 ENOG4107Y49 methyltransferase BTF1_26545 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BTF1_26550 ENOG4105XPM ribosomal protein BTF1_26660 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BTF1_26685 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BTF1_26695 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BTF1_26705 ENOG41067V7 50S ribosomal protein L36 BTF1_26730 ENOG4108JJB ABC transporter BTF1_26735 ENOG4108JJB ABC transporter BTF1_26740 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BTF1_26745 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BTF1_26770 ENOG4105D1F ATP-binding protein BTF1_26785 ENOG4108NMV polysaccharide deacetylase BTF1_26805 ENOG4105C8B TIGR00159 family BTF1_26810 ENOG4107U5W ybbr family BTF1_26825 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BTF1_26845 ENOG4108PSK reductase BTF1_26850 ENOG4108UMI ABC transporter, permease BTF1_26855 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTF1_26860 ENOG4105D01 (LipO)protein BTF1_26865 ENOG4105CB2 alcohol dehydrogenase BTF1_26875 ENOG4105IQ5 FAD linked oxidase domain protein BTF1_26890 ENOG4105C2C drug resistance transporter, Bcr CflA BTF1_26910 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTF1_26915 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTF1_26920 ENOG4105C3U ABC transporter BTF1_26925 ENOG4108JQ7 (ABC) transporter BTF1_26945 ENOG4108J59 Extracellular solute-binding protein, family 5 BTF1_26975 ENOG4105E0C molybdate abc transporter BTF1_26980 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BTF1_26985 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BTF1_27020 ENOG4105F6E Acyl-transferase BTF1_27045 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BTF1_27065 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BTF1_27090 ENOG4105C5H ABC transporter BTF1_27100 ENOG4105DEF Extracellular solute-binding protein, family 5 BTF1_27110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTF1_27115 ENOG4105C3U ABC transporter BTF1_27120 ENOG4108JQ7 (ABC) transporter BTF1_27125 ENOG410667J hydrolase BTF1_27140 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BTF1_27145 ENOG4105ERH Fumarylacetoacetate hydrolase BTF1_27155 ENOG4105CUB amino acid BTF1_27160 ENOG4108SC4 )-transporter BTF1_27165 ENOG4105CPF Cell wall formation (By similarity) BTF1_27170 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BTF1_27195 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BTF1_27200 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BTF1_27210 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BTF1_27230 ENOG4105K8N protein family UPF0079, ATPase BTF1_27235 ENOG41072GX Peptidase M22 Glycoprotease BTF1_27240 ENOG410801F ribosomal-protein-alanine acetyltransferase BTF1_27245 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BTF1_27250 ENOG4105C5H ABC transporter BTF1_27265 ENOG4108TYN CAAX amino terminal protease family protein BTF1_27345 ENOG4108IBT Inherit from COG: transposase BTF1_27385 ENOG4106BHR ftsk SpoIIIE family protein BTF1_27395 ENOG4106128 DNA-binding helix-turn-helix protein BTF1_27410 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BTF1_27420 ENOG4105C7N Xanthine uracil vitamin C permease BTF1_27430 ENOG4105BZU Histidine kinase BTF1_27440 ENOG4107ZXU DSBA oxidoreductase BTF1_27445 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTF1_27485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTF1_27490 ENOG410631K Membrane BTF1_27500 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BTF1_27505 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BTF1_27510 ENOG4105C83 adenylosuccinate lyase BTF1_27520 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BTF1_27545 ENOG4108V3E phosphoribosylglycinamide formyltransferase BTF1_27555 ENOG4105C12 Phosphoribosylglycinamide synthetase BTF1_27580 ENOG4105C4R Atp-dependent dna helicase BTF1_27605 ENOG4108W2Y isochorismatase BTF1_27610 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTF1_27615 ENOG4108UMI ABC transporter, permease BTF1_27620 ENOG4105D01 (LipO)protein BTF1_27640 ENOG410834F Transcriptional regulator BTF1_27645 ENOG4107I77 yiaA/B two helix domain BTF1_27665 ENOG4105CBD Diacylglycerol kinase BTF1_27675 ENOG4108JPW Aminotransferase BTF1_27685 ENOG4105C26 Dehydrogenase BTF1_27690 ENOG4105KPY Small multidrug resistance protein BTF1_27720 ENOG4105D9N nucleoside BTF1_27725 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BTF1_27735 ENOG4108W15 Protein of unknown function (DUF1456) BTF1_27755 ENOG4105DTQ mandelate racemase muconate lactonizing BTF1_27765 ENOG4105DFD Na H antiporter BTF1_27785 ENOG4105D3R alkyl hydroperoxide reductase BTF1_27790 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BTF1_27795 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BTF1_27800 ENOG4107W7X Aldolase BTF1_27805 ENOG4105DQ6 Transposase BTF1_27815 ENOG4105EHG Permease protein BTF1_27820 ENOG4105DQ5 transport system permease protein BTF1_27825 ENOG4108V5C ABC transporter BTF1_27850 ENOG4106UIA BTF1_27855 ENOG4106UIA BTF1_27875 ENOG4105BZU Histidine kinase BTF1_27895 ENOG410756H nucleotidyltransferase BTF1_27900 ENOG4105D2S major facilitator superfamily BTF1_27915 ENOG4105E5Q amino acid AbC transporter BTF1_27920 ENOG4105EAB amino acid AbC transporter BTF1_27925 ENOG4105CDA abc transporter atp-binding protein BTF1_27930 ENOG4105C8Q Methyl-accepting chemotaxis BTF1_27945 ENOG4105DBV ornithine carbamoyltransferase BTF1_27955 ENOG4105C5B carbamate kinase BTF1_27960 ENOG4108W63 CRP FNR family transcriptional regulator BTF1_27970 ENOG4105DNP FAD linked oxidase domain protein BTF1_27980 ENOG4105CI1 PTS System BTF1_27995 ENOG4105C9U ATP-dependent DNA helicase RecQ BTF1_28010 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BTF1_28030 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BTF1_28035 ENOG4105D2X ABC transporter substrate-binding protein BTF1_28045 ENOG4105C5H ABC transporter BTF1_28075 ENOG41062JF Transcriptional regulator BTF1_28090 ENOG4105DEU major facilitator superfamily BTF1_28787 ENOG4105D9P serine threonine protein kinase BTF1_28862 ENOG4105EQI Metal Dependent Phosphohydrolase BTF1_28942 ENOG410906U SprT-like BTF1_28972 ENOG4105C2M dna polymerase I BTF1_29092 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTF1_29097 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTF1_29147 ENOG4105MZU cell filamentation protein BTF1_29222 ENOG4105IEH endo-beta-N-acetylglucosaminidase BTF1_29367 ENOG4108VXD carboxy-peptidase BTF1_29577 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BTF1_29647 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTF1_29652 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTF1_29892 ENOG4107XK4 dna polymerase iii subunits gamma and tau BTF1_30177 ENOG4105C2M dna polymerase I BTF1_30442 ENOG4105C4R Atp-dependent dna helicase BTF1_30547 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BTF1_30957 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BTF1_30992 ENOG4105K4W Could be involved in septation (By similarity) BTF1_31017 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BTF1_31082 ENOG4105C0B DNA polymerase III (alpha subunit) BTF1_31092 ENOG4105C0B DNA polymerase III (alpha subunit) BTF1_31107 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BTF1_31117 ENOG4105EKQ RNA-directed DNA polymerase BTF1_31127 ENOG4105GJD protein, conserved in bacteria BTF1_31172 ENOG4107JM4 Tetratricopeptide repeat BTF1_31222 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BTF1_31252 ENOG4108UUM single-stranded DNA-binding protein BTF1_31262 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BTF1_31292 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BTF1_31297 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BTF1_31317 ENOG4105C4R Atp-dependent dna helicase BTF1_31322 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BTF1_31327 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BTF1_31367 ENOG4105K6T rare lipoprotein A BTF1_31372 ENOG4105C0D helicase BTF1_31387 ENOG4105BZU Histidine kinase BTF1_31392 ENOG4105GR3 Histidine kinase BTF1_31412 ENOG4105ZMH deoxynucleoside kinase BTF1_31592 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BTF1_31602 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BTF1_31617 ENOG4106FN3 tellurium resistance protein BTF1_31622 ENOG4106FN3 tellurium resistance protein BTF1_31632 ENOG4107TS3 membrane protein, TerC BTF1_31642 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BTF1_31652 ENOG4105D9N nucleoside BTF1_31677 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BTF1_31682 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BTF1_31687 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BTF1_31692 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BTF1_31727 ENOG4108IBT Inherit from COG: transposase BTF1_31896 ENOG4105EA8 2-Nitropropane dioxygenase BTF1_31911 ENOG4108BUD transposase BTF1_31936 ENOG4105E1K spore germination protein BTF1_31966 ENOG4105K70 DNA-binding protein BTF1_31971 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTF1_31976 ENOG4105KRN Transcriptional regulator, abrb family BTF1_31991 ENOG4105C87 Aminotransferase class I and II BTF1_31996 ENOG410880H cysteine synthase BTF1_32001 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTF1_32071 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BTF1_32221 ENOG4105KRN Transcriptional regulator, abrb family BTF1_32226 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTF1_32251 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTF1_32276 ENOG4105C19 ABC transporter BTF1_32281 ENOG4107RBB ABC transporter, permease BTF1_32446 ENOG4108BUD transposase BTF1_32496 ENOG4105CNA YD repeat protein BTF1_32501 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BTF1_32556 ENOG4105K7K Transcriptional regulator BTF1_32561 ENOG4105BZ1 (ABC) transporter BTF1_32566 ENOG4105CJA serine threonine protein kinase BTF1_32876 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BTF1_32896 ENOG4105D13 transposase BTF1_32921 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BTF1_32981 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)