locus-tag class description AS86_1 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AS86_1002 ENOG41068WN AS86_1006 ENOG4105VMP Transcriptional regulator AS86_1008 ENOG4105G6Z alkaline phosphatase AS86_1009 ENOG4107RBI VanW family AS86_101 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AS86_1011 ENOG4105ECK Fatty Acid Desaturase AS86_1016 ENOG4107258 Transcriptional regulator AS86_1018 ENOG4105II7 pyrroline-5-carboxylate reductase AS86_1024 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AS86_1027 ENOG41061GT Aldolase AS86_1029 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AS86_103 ENOG4105CNU cell division protein FtsK AS86_1030 ENOG4105DKT Transcriptional regulator AS86_1032 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AS86_1034 ENOG4105D4B ABC, transporter AS86_104 ENOG4105FDP GntR family transcriptional regulator AS86_1041 ENOG41069ER domain protein AS86_1048 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AS86_1049 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AS86_105 ENOG4105DIH basic membrane AS86_1054 ENOG41082JN Transcriptional regulator AS86_1055 ENOG4105EYF MMPL domain protein AS86_1056 ENOG4105C5H ABC transporter AS86_1057 ENOG4105E0M Sulfatase AS86_1058 ENOG4108ZCF integral membrane protein AS86_106 ENOG4108JQ9 ABC transporter AS86_1062 ENOG4107VMI polysaccharide deacetylase AS86_1065 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AS86_1066 ENOG4105C6T cysteine synthase AS86_1067 ENOG4107VC0 DNA alkylation repair enzyme AS86_107 ENOG4105UIB (ABC) transporter AS86_1074 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AS86_1079 ENOG4105D7T ABC transporter AS86_1080 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AS86_1081 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AS86_1084 ENOG4105C02 permease AS86_1095 ENOG4105CHM Aminotransferase AS86_11 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AS86_1102 ENOG41089UC methyltransferase, type 11 AS86_1105 ENOG4107BMA Transglycosylase associated protein AS86_1109 ENOG4106K7D Major facilitator family transporter AS86_111 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AS86_1110 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AS86_112 ENOG4105XZV Protein of unknown function (DUF3243) AS86_1122 ENOG4105EPR degv family AS86_1123 ENOG4105DPN Oligoendopeptidase f AS86_1128 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_1129 ENOG4105BZU Histidine kinase AS86_1130 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS86_1131 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AS86_1138 ENOG4107SET aldo keto reductase AS86_1141 ENOG4105DTQ mandelate racemase muconate lactonizing AS86_1144 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AS86_1146 ENOG4107T5V SNARE associated Golgi AS86_115 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AS86_1154 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein AS86_1156 ENOG41080HI glycine oxidase AS86_1157 ENOG4105CTU Proline racemase AS86_1159 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AS86_1160 ENOG4105C26 Dehydrogenase AS86_1161 ENOG4105BZG amino acid carrier protein AS86_1165 ENOG4108M1A Chitin-binding protein AS86_1176 ENOG4105C9U ATP-dependent DNA helicase RecQ AS86_1179 ENOG4105EEM helicase AS86_1180 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AS86_1185 ENOG4108Z7F N-acetyltransferase AS86_119 ENOG4105D48 metallophosphoesterase AS86_1190 ENOG4105MSB protein, conserved in bacteria AS86_1191 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS86_1194 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AS86_1196 ENOG41087PP glycosyltransferase MGT family AS86_1197 ENOG4108M1A Chitin-binding protein AS86_120 ENOG4105MCT stage V sporulation protein S AS86_1201 ENOG41082BV acetyltransferase AS86_1202 ENOG4105E66 phosphoriboisomerase A AS86_1205 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AS86_1207 ENOG4108IJ7 Glycine betaine AS86_1208 ENOG4107SQ8 Glycine betaine AS86_121 ENOG4108IGT Dipeptidase AS86_1215 ENOG4105RHY Pfam:UPF0157 AS86_1216 ENOG4105E1F short-chain dehydrogenase reductase AS86_1219 ENOG4107RUY (E1 component), alpha subunit AS86_122 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AS86_1221 ENOG4107QKR Dehydrogenase AS86_1225 ENOG41062ES Transcriptional regulator AS86_1228 ENOG4105E98 transcriptional regulator DeoR family AS86_123 ENOG4105DQU oxidoreductase, subunit beta AS86_1232 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AS86_1236 ENOG4107Z3H Transcriptional regulator, TetR family AS86_1237 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AS86_1238 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AS86_1244 ENOG4105MSI germination protein ypeb AS86_1255 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS86_1256 ENOG4105FDR Membrane AS86_1257 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AS86_1258 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AS86_1261 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AS86_1263 ENOG4108IUM Glycogen debranching enzyme AS86_1266 ENOG4105DY8 decarboxylase AS86_1269 ENOG4107WD8 ABC transporter, permease AS86_1273 ENOG4105BZU Histidine kinase AS86_1274 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_1275 ENOG4105U0R haloacid dehalogenase-like hydrolase AS86_1280 ENOG4107VFR oxidoreductase AS86_1283 ENOG41087PP glycosyltransferase MGT family AS86_1284 ENOG41087PP glycosyltransferase MGT family AS86_1292 ENOG4105PKS Excinuclease abc c subunit domain protein AS86_1294 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AS86_130 ENOG410890F Dynamin family AS86_1300 ENOG4105KWG Pfam:DUF1696 AS86_1301 ENOG4108NRW Phospholipase, patatin family AS86_1305 ENOG4108XI2 Domain of unknown function (DUF1963) AS86_131 ENOG4105E0M Sulfatase AS86_1310 ENOG4108Z4K mutator MutT protein AS86_1311 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AS86_1314 ENOG4105FCD Major Facilitator AS86_1318 ENOG4105M6F mutator MutT protein AS86_1319 ENOG4105EGD dinuclear metal center protein, YbgI family AS86_1323 ENOG4107Y9U Membrane AS86_1328 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AS86_133 ENOG4105F0V Cell wall hydrolase AS86_1333 ENOG4107Y80 Major Facilitator superfamily AS86_1342 ENOG4105CJN penicillin-binding protein AS86_1343 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AS86_1344 ENOG4105CB2 alcohol dehydrogenase AS86_135 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C AS86_136 ENOG4105C8Q Methyl-accepting chemotaxis AS86_1363 ENOG4108HGU Histidine kinase AS86_1366 ENOG4108JJB ABC transporter AS86_1371 ENOG4105F6S Spore photoproduct lyase AS86_1373 ENOG4105XZV Protein of unknown function (DUF3243) AS86_1375 ENOG4105ECP epimerase AS86_1377 ENOG4105DQ6 Transposase AS86_1379 ENOG4105WG9 Conserved Protein AS86_1382 ENOG4108606 TspO/MBR family AS86_1383 ENOG4105CVP deoxyribo-dipyrimidine photolyase AS86_1388 ENOG41082BM Transcriptional regulator, arsr family AS86_1390 ENOG4105D9M gamma-glutamylcysteine synthetase AS86_1392 ENOG4105C4W S-formylglutathione hydrolase AS86_1394 ENOG4105KVH Transcriptional regulator AS86_14 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AS86_140 ENOG41067MG lrgb family AS86_1405 ENOG4108VJ1 Transcriptional regulator (CarD family AS86_1408 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein AS86_1417 ENOG4108FPN Integrase AS86_1422 ENOG4107RF6 penicillin-binding protein AS86_1423 ENOG4105BZU Histidine kinase AS86_1424 ENOG410667J hydrolase AS86_1442 ENOG4105ETU transcriptional activator (TenA AS86_1443 ENOG4105CPF Cell wall formation (By similarity) AS86_1445 ENOG4105D6E homoserine dehydrogenase AS86_1454 ENOG4105CPC Aldo Keto reductase AS86_1455 ENOG4106NZI LysR family Transcriptional regulator AS86_1460 ENOG4105DK7 lysyl-tRNA synthetase AS86_1462 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AS86_1464 ENOG4108V4B ThiJ pfpI AS86_1467 ENOG410900G Protein of unknown function (DUF421) AS86_147 ENOG4105BZU Histidine kinase AS86_1481 ENOG4105KVH Transcriptional regulator AS86_1482 ENOG4105CHR reductase AS86_1484 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS86_1490 ENOG41075H3 AraC family transcriptional regulator AS86_1495 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AS86_1498 ENOG4105T9C HD domain AS86_15 ENOG4105C79 DNA protecting protein DprA AS86_1501 ENOG4105DZ1 carboxypeptidase AS86_1507 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AS86_1508 ENOG4107QX3 carboxylase AS86_1509 ENOG4105E39 Enoyl-CoA hydratase AS86_1510 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AS86_1511 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AS86_1512 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AS86_1513 ENOG4105C1G acyl-Coa dehydrogenase AS86_1516 ENOG4107Z3H Transcriptional regulator, TetR family AS86_1521 ENOG4105DIN metallophosphoesterase AS86_1523 ENOG4107RF6 penicillin-binding protein AS86_1524 ENOG4105DQ6 Transposase AS86_1526 ENOG4107RF6 penicillin-binding protein AS86_1529 ENOG4107RVG penicillin-binding protein AS86_153 ENOG4105D03 DNA-3-methyladenine glycosylase II AS86_1537 ENOG4107VMI polysaccharide deacetylase AS86_1539 ENOG4108IMY Transcriptional regulator AS86_154 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AS86_1547 ENOG4108SC4 )-transporter AS86_1548 ENOG4105IIU Aminopeptidase AS86_1550 ENOG4105FJR Lmbe family AS86_1553 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AS86_1554 ENOG4108IAJ Nad-dependent epimerase dehydratase AS86_1555 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AS86_1556 ENOG4107QQG Dehydrogenase AS86_1557 ENOG4108W0I acetyltransferase AS86_156 ENOG4105CGK Exodeoxyribonuclease III AS86_1568 ENOG4105CHR reductase AS86_1570 ENOG4105W8Z 4'-phosphopantetheinyl transferase AS86_1579 ENOG4105EJ9 Membrane AS86_1581 ENOG4105KRN Transcriptional regulator, abrb family AS86_1587 ENOG4105CIN aminoacyl-histidine dipeptidase AS86_1594 ENOG4107RA9 decarboxylase AS86_1595 ENOG4108I0C methyltransferase AS86_1597 ENOG41088CC tellurite resistance protein tehB AS86_1598 ENOG4105C1J atp-dependent rna helicase AS86_16 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AS86_160 ENOG4105E0A ABC, transporter AS86_1600 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AS86_1603 ENOG4108INS Transcriptional regulator AS86_1604 ENOG4105C7B Threonine dehydratase AS86_1605 ENOG4107STF Involved in phosphonate degradation (By similarity) AS86_1606 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AS86_1607 ENOG4105RD7 BadF BadG BcrA BcrD AS86_161 ENOG4105NIV Esterase AS86_1612 ENOG4105F32 YngK protein AS86_1617 ENOG4108KPJ rna polymerase sigma factor AS86_1618 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AS86_1624 ENOG4108JCI Transcriptional regulator AS86_1630 ENOG4105BZ1 (ABC) transporter AS86_1631 ENOG4105BZ1 (ABC) transporter AS86_1634 ENOG4108RPX mosc domain containing protein AS86_1635 ENOG4105DND Transcriptional regulator AS86_1637 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AS86_1638 ENOG4107V2S Transcriptional regulator AS86_1644 ENOG41068WN AS86_1646 ENOG4105C1Q protoporphyrinogen oxidase AS86_165 ENOG4105VPX protein, conserved in bacteria AS86_1651 ENOG4105WCN acetyltransferase AS86_1656 ENOG4105EYF MMPL domain protein AS86_1658 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AS86_166 ENOG410681U heavy metal transport detoxification protein AS86_1662 ENOG4108Y4K DNA-binding transcriptional activator AS86_1664 ENOG41081I9 integral membrane protein AS86_167 ENOG4105C59 p-type ATPase AS86_1670 ENOG4105C19 ABC transporter AS86_1671 ENOG4105C22 threonyL-tRNA synthetase AS86_1672 ENOG4105FE9 pseudouridine synthase AS86_1676 ENOG4105BZG amino acid carrier protein AS86_1680 ENOG4105K70 DNA-binding protein AS86_1683 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS86_1684 ENOG4105WQT MbtH domain protein AS86_1685 ENOG4105CEY Amp-dependent synthetase and ligase AS86_1686 ENOG4105WQI isochorismatase AS86_1687 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AS86_1688 ENOG4105E4F Isochorismate synthase AS86_1689 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AS86_169 ENOG4105K70 DNA-binding protein AS86_1690 ENOG4105FCD Major Facilitator AS86_1694 ENOG4105EYH Exonuclease AS86_1695 ENOG4107RFY SbcCD D subunit AS86_1698 ENOG4105E39 Enoyl-CoA hydratase AS86_1699 ENOG4105N14 lysine exporter protein LysE YggA AS86_170 ENOG4105TMB Formate nitrite transporter AS86_1701 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AS86_1702 ENOG4105C1G acyl-Coa dehydrogenase AS86_1703 ENOG4105CR4 methylisocitrate lyase AS86_1704 ENOG4105DXD 2-methylcitrate dehydratase AS86_1706 ENOG4105W8X HesB YadR YfhF-family protein AS86_1707 ENOG4105CZM Major Facilitator AS86_1709 ENOG4105BZ4 penicillin-binding protein AS86_1720 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS86_1728 ENOG4105SZ6 Thioredoxin AS86_1729 ENOG410841Q phosphoesterase PA-phosphatase related protein AS86_1739 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AS86_174 ENOG4105C85 amino acid AS86_1740 ENOG4108JUB Transcriptional regulator AS86_1741 ENOG4108TSC N-acetyltransferase AS86_1742 ENOG4107S4Y M20 DapE family protein YgeY AS86_1745 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS86_1750 ENOG4105C37 (CBS) domain AS86_1757 ENOG4105E90 ABC transporter AS86_1758 ENOG4108IJ8 ABC transporter AS86_1764 ENOG4108YV3 Protein of unknown function (DUF2711) AS86_1766 ENOG4105C6Z Gluconate AS86_1767 ENOG4105CMG Carbohydrate kinase AS86_177 ENOG4108SJC Membrane AS86_1772 ENOG4107ZY0 Phenazine biosynthesis-like protein AS86_1773 ENOG4106KNT transcriptional regulator AS86_1774 ENOG4105WH1 Two component transcriptional regulator luxr family AS86_1775 ENOG4105BZU Histidine kinase AS86_1776 ENOG4105D8X mechanosensitive ion channel AS86_178 ENOG4107QW4 alcohol dehydrogenase AS86_1781 ENOG4105F0I Aminotransferase AS86_1782 ENOG4108MES Periplasmic binding protein AS86_1783 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AS86_1786 ENOG4105CAQ asparagine synthetase AS86_1787 ENOG4107Y70 Heat shock protein AS86_1788 ENOG4108KF3 Electron transport protein SCO1 SenC AS86_179 ENOG4105E98 transcriptional regulator DeoR family AS86_1790 ENOG4108RCR degv family AS86_1792 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AS86_1794 ENOG4108UT2 hemolysin iii AS86_1795 ENOG4105E9Q Acyl-transferase AS86_1797 ENOG4107RVG penicillin-binding protein AS86_18 ENOG4108HE4 integrase family AS86_180 ENOG4105DE4 1-phosphofructokinase AS86_1803 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AS86_1808 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AS86_1809 ENOG4105VMP Transcriptional regulator AS86_181 ENOG4105DM4 PTS System AS86_1810 ENOG4105KD7 acetyltransferase AS86_1814 ENOG4105CY2 Citrate transporter AS86_1815 ENOG4107XGZ Hydrolase AS86_1818 ENOG4108EF6 Proline imino-peptidase AS86_1819 ENOG4105C8J )-transporter AS86_182 ENOG41069ER domain protein AS86_1820 ENOG4105C5S asparaginyl-tRNA synthetase AS86_1823 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AS86_1828 ENOG4105C75 arginyL-tRNA synthetase AS86_1829 ENOG4107YX5 Pfam:DUF548 AS86_1834 ENOG4108UUM single-stranded DNA-binding protein AS86_1837 ENOG4105C5H ABC transporter AS86_1845 ENOG4105MCT stage V sporulation protein S AS86_1852 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AS86_1853 ENOG4108IFG nitrite reductase, (NAD(P)H) AS86_1854 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AS86_1855 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AS86_1856 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AS86_1857 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AS86_1862 ENOG4108ZAF Molybdopterin AS86_1863 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS86_1864 ENOG4105D06 uba thif-type nad fad binding protein AS86_1865 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AS86_1866 ENOG4107V6Q Cyclic nucleotide-binding domain AS86_1868 ENOG4105R3A Nitrate reductase AS86_1869 ENOG4108IUE nitrate reductase beta subunit AS86_1871 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS86_1874 ENOG4108V06 Glutathione peroxidase AS86_1876 ENOG4105CNW domain protein AS86_1878 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AS86_188 ENOG4106F1P AAA ATPase, central domain protein AS86_1880 ENOG4105EMN RNA polymerase sigma factor AS86_1881 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AS86_1883 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AS86_1884 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AS86_1888 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AS86_1893 ENOG4105KBJ sporulation protein ytfj AS86_1895 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS86_190 ENOG4105EN6 Membrane AS86_191 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AS86_192 ENOG4105CXI aluminum resistance protein AS86_1921 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) AS86_1923 ENOG4106PAW secretion accessory protein EsaA YueB AS86_1928 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AS86_193 ENOG4105KV4 Transcriptional regulator AS86_1934 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS86_1935 ENOG4108JYZ YitT family AS86_1936 ENOG41087PP glycosyltransferase MGT family AS86_1939 ENOG4107RBS Methyltransferase AS86_194 ENOG4105C5F glutamine synthetase AS86_1940 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AS86_1942 ENOG4105D94 Major Facilitator Superfamily AS86_1943 ENOG41082F9 transcriptional regulator AS86_1944 ENOG4108X4Q Hydrolase AS86_1946 ENOG4108ZRV stage ii sporulation protein p AS86_1952 ENOG4108VXD carboxy-peptidase AS86_1954 ENOG4108ZRV stage ii sporulation protein p AS86_1957 ENOG4108Z7R Chaperone CsaA AS86_1963 ENOG4105C37 (CBS) domain AS86_1964 ENOG4105SXS Protein of unknown function (DUF456) AS86_1968 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS86_1969 ENOG4108S4H thioesterase Superfamily protein AS86_1971 ENOG4108PJD permease AS86_1974 ENOG4107T5V SNARE associated Golgi AS86_1978 ENOG4105CVJ phosphoglycerate mutase AS86_1983 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AS86_1985 ENOG4105K4T epimerase AS86_1987 ENOG4105DSE periplasmic solute binding protein AS86_1989 ENOG4105CKI cobalamin synthesis protein AS86_1990 ENOG4107QM2 Aldo Keto reductase AS86_1991 ENOG4105VMI -acetyltransferase AS86_1994 ENOG4105DEN Luciferase family AS86_1997 ENOG4108WPJ Ferritin-like domain AS86_1998 ENOG4108K88 Membrane AS86_2 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AS86_2001 ENOG4105C8Q Methyl-accepting chemotaxis AS86_2007 ENOG4105CPC Aldo Keto reductase AS86_2008 ENOG4105YVS arsR family transcriptional regulator AS86_2010 ENOG4105KRN Transcriptional regulator, abrb family AS86_202 ENOG41065S2 pneumococcal vaccine antigen AS86_2020 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS86_2021 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AS86_2023 ENOG4105YWU small acid-soluble spore protein AS86_2024 ENOG4108WBH protein TIM barrel AS86_2027 ENOG4105CEY Amp-dependent synthetase and ligase AS86_2028 ENOG4105DUU IucA IucC family protein AS86_203 ENOG4105E4C Lytic transglycosylase catalytic AS86_2030 ENOG4105VRR gCN5-related N-acetyltransferase AS86_2031 ENOG4105KT7 mgtC SapB transporter AS86_2033 ENOG4107VMI polysaccharide deacetylase AS86_2034 ENOG4108KGH TRANSCRIPTIONal AS86_2039 ENOG4105D6E homoserine dehydrogenase AS86_2043 ENOG4108ZJ4 polysaccharide deacetylase AS86_2044 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AS86_2046 ENOG4108VQJ O-methyltransferase AS86_2048 ENOG4105BZU Histidine kinase AS86_2049 ENOG4105EFI regulatoR AS86_205 ENOG4105K7K Transcriptional regulator AS86_2050 ENOG4105BZ1 (ABC) transporter AS86_2061 ENOG4108UT6 Transferase hexapeptide repeat containing protein AS86_2063 ENOG4105K64 Glycosyl transferase, family 2 AS86_2065 ENOG4108JJ8 (ABC) transporter AS86_2066 ENOG4108JJ9 ABC, transporter AS86_2067 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AS86_2068 ENOG4105C4M (Ubiquinol oxidase) subunit I AS86_2075 ENOG4105EGI Transcriptional regulator AS86_2077 ENOG4105C32 Amino acid ABC transporter (Permease) AS86_2078 ENOG4108IV0 ABC, transporter AS86_2079 ENOG4105C0Z ABC transporter AS86_2081 ENOG4105CKI cobalamin synthesis protein AS86_2083 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS86_2084 ENOG4106F5Q Membrane AS86_2085 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AS86_2087 ENOG4108TVJ Nitroreductase AS86_2088 ENOG4107ZXU DSBA oxidoreductase AS86_2089 ENOG4108Z40 Transcriptional regulator AS86_209 ENOG4108SVB resolvase AS86_2090 ENOG4105GZI Transcriptional regulator AS86_2091 ENOG4107RT3 EamA-like transporter family AS86_2092 ENOG4105KTB nuclear export factor GLE1 AS86_2093 ENOG4108T5E Copper resistance protein AS86_2102 ENOG4107R16 Multicopper oxidase AS86_2104 ENOG4107RAQ aminopeptidase AS86_211 ENOG4105CGH 5'-nucleotidase AS86_2111 ENOG4108IBT Inherit from COG: transposase AS86_2114 ENOG4105KG3 cytidine deaminase AS86_2115 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AS86_2116 ENOG4105D9N nucleoside AS86_2118 ENOG4107RHR regulatoR AS86_212 ENOG4108HW3 (ABC) transporter AS86_2121 ENOG4105K8R UPF0145 protein AS86_2122 ENOG410849A acetyltransferase, (GNAT) family AS86_2129 ENOG4105C0X amino acid AS86_2131 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AS86_2135 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AS86_2139 ENOG41068WN AS86_2144 ENOG4105CYC Transferase AS86_2145 ENOG4105DY9 regulatoR AS86_2148 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AS86_2149 ENOG4105C6X Major Facilitator AS86_2154 ENOG4105C7B Threonine dehydratase AS86_2156 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AS86_2158 ENOG4105C7K acetolactate synthase AS86_2159 ENOG4105CM2 brancheD-chain amino acid aminotransferase AS86_2160 ENOG4105CHR reductase AS86_2165 ENOG4105H67 Protein of unknown function (DUF421) AS86_2166 ENOG4105X5K response regulator receiver protein AS86_2168 ENOG4105C8J )-transporter AS86_2172 ENOG4105C6T cysteine synthase AS86_2173 ENOG4105EU0 Major facilitator Superfamily AS86_2174 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AS86_2176 ENOG4105DXI Major Facilitator superfamily AS86_2178 ENOG4105U3E Transcriptional regulator AS86_2179 ENOG4105CSR polyphosphate kinase 2 AS86_2182 ENOG4105E09 nadh pyrophosphatase AS86_2183 ENOG4105FVX AS86_219 ENOG4105BZ1 (ABC) transporter AS86_2193 ENOG4105C6K Malic enzyme AS86_2194 ENOG4108IJ0 Aspartate ammonia-lyase AS86_2196 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AS86_220 ENOG4105BZ1 (ABC) transporter AS86_2200 ENOG4105CJ1 ABC, transporter AS86_2207 ENOG4106BRA Membrane AS86_2210 ENOG4107JM4 Tetratricopeptide repeat AS86_2213 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS86_2214 ENOG4107QIV Cytochrome c biogenesis protein AS86_2218 ENOG4105EC3 peptidase S51, dipeptidase E AS86_2219 ENOG4107QJQ Mate efflux family protein AS86_2223 ENOG4105C9Q fumarate hydratase class II AS86_2225 ENOG4105VUF Transcriptional regulator AS86_2226 ENOG4105DFD Na H antiporter AS86_2229 ENOG4108PJD permease AS86_2230 ENOG4105CKI cobalamin synthesis protein AS86_2233 ENOG4105PGM cation diffusion facilitator family transporter AS86_2237 ENOG4105CAQ asparagine synthetase AS86_2239 ENOG4105K56 Transcriptional regulator AS86_2241 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AS86_2243 ENOG4105CVJ phosphoglycerate mutase AS86_2249 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AS86_2250 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AS86_2252 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS86_2253 ENOG4105DUM transcriptional regulator, lysR family AS86_2258 ENOG4107QZ7 Cellulose synthase catalytic subunit AS86_2259 ENOG4105KAC Antibiotic biosynthesis monooxygenase AS86_2265 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS86_2266 ENOG4105CPU Monooxygenase AS86_2267 ENOG4105KTQ flagellar basal-body rod protein AS86_2268 ENOG4105FZW flagellar biosynthesis regulator FlhF AS86_2269 ENOG4105D7B Flagellar biosynthesis protein flha AS86_2270 ENOG4105D00 flagellar biosynthetic protein flhB AS86_2272 ENOG4105VS8 Flagellar biosynthetic protein fliq AS86_2273 ENOG4105CN7 Flagellar biosynthetic protein FliP AS86_2275 ENOG4105DD5 Flagellar motor switch protein AS86_2276 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AS86_2278 ENOG4105E4C Lytic transglycosylase catalytic AS86_2279 ENOG4105I03 Flagellin AS86_228 ENOG41067MG lrgb family AS86_2285 ENOG4107R88 Chemotaxis protein (CheV) AS86_2288 ENOG4105BZE flagellar hook protein, FlgE AS86_229 ENOG4105VAW lrga family AS86_2294 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AS86_2295 ENOG4107U2N Flagellar M-ring protein AS86_2296 ENOG41075Z6 flagellar hook-basal body complex protein fliE AS86_2297 ENOG4108ZC9 flagellar basal-body rod protein flgc AS86_2298 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AS86_230 ENOG4107RSM transcriptional regulator AS86_2302 ENOG4105DTJ flagellar hook-associated protein AS86_2303 ENOG4105E1Q flagellar hook-associated protein AS86_2307 ENOG4105BZU Histidine kinase AS86_2310 ENOG4105DD5 Flagellar motor switch protein AS86_2311 ENOG4105CBS Chea signal transduction histidine kinase AS86_2312 ENOG4107YTP response regulator receiver protein AS86_2313 ENOG4105ER2 Ompa motb domain protein AS86_2314 ENOG4107R0U MotA TolQ exbB proton channel AS86_2316 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AS86_2323 ENOG41080C8 DUF218 domain AS86_2324 ENOG4105H67 Protein of unknown function (DUF421) AS86_2326 ENOG4108Z5V transcriptional regulator, merr family AS86_2329 ENOG4107RWR Sodium hydrogen exchanger AS86_2331 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS86_234 ENOG4105CJ1 ABC, transporter AS86_2344 ENOG41081VK Ribonuclease AS86_2348 ENOG4108SZE gCN5-related N-acetyltransferase AS86_2351 ENOG4105CPK Glycosyl transferase (Group 1 AS86_2357 ENOG4105HTX biosynthesis protein AS86_236 ENOG4105CH2 amidohydrolase AS86_2363 ENOG4106032 Glutathionylspermidine synthase AS86_2366 ENOG4105KHC sulfurtransferase AS86_2368 ENOG4108W0I acetyltransferase AS86_2370 ENOG410890F Dynamin family AS86_2371 ENOG4105DHF Membrane AS86_2372 ENOG4105C2W permease AS86_2374 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AS86_2377 ENOG4105CTD carboxy-peptidase AS86_2378 ENOG4105DVT helicase AS86_238 ENOG4107QIV Cytochrome c biogenesis protein AS86_2380 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AS86_2391 ENOG4105BZ4 penicillin-binding protein AS86_2393 ENOG4105CSM endonuclease III AS86_2397 ENOG4105YAC AS86_2398 ENOG4105DVT helicase AS86_24 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AS86_2405 ENOG4105CPK Glycosyl transferase (Group 1 AS86_2406 ENOG4105FJR Lmbe family AS86_2409 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AS86_2410 ENOG4108JYZ YitT family AS86_2417 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AS86_2418 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AS86_2421 ENOG41068YB TPR repeat-containing protein AS86_2424 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AS86_2425 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AS86_2426 ENOG4105EAH synthase AS86_2428 ENOG4105XXQ heptaprenyl diphosphate synthase component I AS86_2431 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AS86_2437 ENOG41065D1 AS86_2438 ENOG4105S2F AS86_2445 ENOG4107RB3 L-asparaginase AS86_2446 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AS86_2451 ENOG4108S6Z Negative regulator of genetic competence AS86_2452 ENOG4108XDN Transcriptional regulator AS86_2453 ENOG4107RGJ metallophosphoesterase AS86_2455 ENOG4105I7S Abortive infection protein AS86_2456 ENOG4105C9U ATP-dependent DNA helicase RecQ AS86_2459 ENOG4108SAX Membrane AS86_2461 ENOG41063SB peptidase AS86_2462 ENOG4108WBT adenosyltransferase AS86_2463 ENOG4105BZU Histidine kinase AS86_2464 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_2465 ENOG4105CRE cytochrome C AS86_2466 ENOG4107TWT Cytochrome c biogenesis protein AS86_2467 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS86_2468 ENOG4105FE9 pseudouridine synthase AS86_2470 ENOG4108JIC nucleoside recognition domain protein AS86_2471 ENOG4105DZ1 carboxypeptidase AS86_2472 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS86_2478 ENOG4105BZU Histidine kinase AS86_2481 ENOG4105I3N Conserved Protein AS86_2482 ENOG4105BZU Histidine kinase AS86_2485 ENOG4105BZ4 penicillin-binding protein AS86_2486 ENOG4107GRR phosphate transport regulator AS86_2487 ENOG4105CJ3 phosphate transporter AS86_249 ENOG4108903 Formimidoylglutamase AS86_2491 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AS86_2496 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AS86_250 ENOG4108VJ1 Transcriptional regulator (CarD family AS86_2500 ENOG4105WH1 Two component transcriptional regulator luxr family AS86_2501 ENOG4105ENE Histidine kinase AS86_2505 ENOG4105DFD Na H antiporter AS86_251 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AS86_2510 ENOG4105C8J )-transporter AS86_2511 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AS86_2512 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AS86_2513 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AS86_2515 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AS86_2516 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AS86_252 ENOG4105CBC glutamate synthase AS86_2520 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AS86_2522 ENOG4105E0M Sulfatase AS86_2523 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AS86_2526 ENOG4107RVV histidinol phosphate phosphatase, hisj family AS86_2533 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AS86_254 ENOG4105CK7 Sodium proline symporter AS86_2540 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AS86_2541 ENOG4108ZP8 Acetolactate synthase small subunit AS86_2542 ENOG4105C7K acetolactate synthase AS86_2543 ENOG4105CM2 brancheD-chain amino acid aminotransferase AS86_2547 ENOG4105KBJ sporulation protein ytfj AS86_2548 ENOG41063Y9 AS86_2549 ENOG4105CZN Potassium uptake protein AS86_255 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AS86_2555 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AS86_256 ENOG4105FBA Phospholipase Carboxylesterase AS86_2563 ENOG4105NQC Flavodoxin AS86_2568 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS86_257 ENOG4105BZU Histidine kinase AS86_2570 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AS86_2571 ENOG4105EA8 2-Nitropropane dioxygenase AS86_2572 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AS86_2580 ENOG4105CJ1 ABC, transporter AS86_2582 ENOG4105CZV ABC transporter AS86_2583 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AS86_2584 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS86_2585 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS86_2586 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AS86_259 ENOG4107AYK membrAne AS86_2594 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AS86_2595 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AS86_2597 ENOG4105BZU Histidine kinase AS86_2599 ENOG4106DF1 AS86_26 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AS86_2601 ENOG41090MY MarR family Transcriptional regulator AS86_2602 ENOG4105BZU Histidine kinase AS86_2604 ENOG4105PXI polysaccharide deacetylase AS86_2606 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AS86_2609 ENOG4105E98 transcriptional regulator DeoR family AS86_2613 ENOG4107RCV ABC transporter, permease AS86_2614 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS86_2615 ENOG4105C4Y ABC transporter AS86_2621 ENOG4105CHR reductase AS86_2625 ENOG4108Z7G MaoC domain protein dehydratase AS86_2626 ENOG410681C small acid-soluble spore protein AS86_2627 ENOG4105CZN Potassium uptake protein AS86_2628 ENOG4107TS3 membrane protein, TerC AS86_2629 ENOG4108QTI )-transporter AS86_2631 ENOG4106A3R peptidase AS86_2635 ENOG4105JXH GntR family transcriptional regulator AS86_2636 ENOG4105BZU Histidine kinase AS86_2637 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_2640 ENOG4105CQB FAD linked oxidase domain protein AS86_2641 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AS86_2642 ENOG4105K4I Scp-like extracellular AS86_2644 ENOG4108YBP pseudouridine synthase AS86_2646 ENOG4105EYF MMPL domain protein AS86_2647 ENOG410841Q phosphoesterase PA-phosphatase related protein AS86_2648 ENOG4107RUE extracellular solute-binding protein family 1 AS86_2649 ENOG4105D38 putrescine abc transporter AS86_2650 ENOG4105F38 ABC transporter, permease AS86_2651 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS86_2652 ENOG4105C26 Dehydrogenase AS86_2659 ENOG4105VFR signal peptidase AS86_266 ENOG4108IMY Transcriptional regulator AS86_2660 ENOG4105DZ1 carboxypeptidase AS86_2662 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AS86_2666 ENOG4105DQ6 Transposase AS86_2668 ENOG4105RHA ABC transporter, permease AS86_2669 ENOG4108IUX (ABC) transporter AS86_267 ENOG4105CEY Amp-dependent synthetase and ligase AS86_2674 ENOG4105VZ8 Transcriptional regulator AS86_2676 ENOG4105C7S Dehydrogenase AS86_268 ENOG4107ZYJ bioY protein AS86_269 ENOG4107F3J Amp-dependent synthetase and ligase AS86_2695 ENOG4105DDQ anthranilate synthase AS86_2696 ENOG4105CRQ synthase (Component I) AS86_2697 ENOG4105CK7 Sodium proline symporter AS86_27 ENOG4105KNE Phosphatidate cytidylyltransferase AS86_2711 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AS86_2713 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AS86_2714 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AS86_2723 ENOG4105K64 Glycosyl transferase, family 2 AS86_2727 ENOG4105EMS pseudouridine synthase AS86_2728 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AS86_273 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS86_2731 ENOG4105MIX Adenylate cyclase AS86_2732 ENOG4108Z18 K06886 hemoglobin AS86_2734 ENOG4105DPN Oligoendopeptidase f AS86_2736 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS86_2738 ENOG4108ZCF integral membrane protein AS86_2742 ENOG4105UQX Mate efflux family protein AS86_2743 ENOG4108JQ7 (ABC) transporter AS86_2745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS86_2746 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS86_2749 ENOG4105C31 Tryptophanyl-tRNA synthetase AS86_275 ENOG4105E5W Transporter AS86_2752 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AS86_2753 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS86_2758 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AS86_2760 ENOG4108KP7 hydrolase AS86_2762 ENOG41073B9 AS86_2763 ENOG4107AYK membrAne AS86_2765 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS86_2775 ENOG4105CNA YD repeat protein AS86_2776 ENOG4105QNR S1 RNA binding domain protein AS86_2780 ENOG4105BZU Histidine kinase AS86_2781 ENOG4105CH6 catalase AS86_2782 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AS86_2783 ENOG4105CAQ asparagine synthetase AS86_2786 ENOG4105C8Y Acetylornithine aminotransferase AS86_2788 ENOG4105ERH Fumarylacetoacetate hydrolase AS86_28 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AS86_2801 ENOG4105XVF Competence transcription factor AS86_2804 ENOG4105VEQ Cold shock protein AS86_2808 ENOG4107QP3 malate synthase g AS86_281 ENOG4108I0Z Aconitate hydratase AS86_2810 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AS86_2812 ENOG4105C8Q Methyl-accepting chemotaxis AS86_2813 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AS86_2817 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS86_282 ENOG4108JJB ABC transporter AS86_2820 ENOG41086D8 Transcriptional regulator AS86_2821 ENOG4108AEY RNA polymerase sigma factor AS86_2823 ENOG4107TVP HD domain protein AS86_2824 ENOG4107RN3 metallophosphoesterase AS86_2825 ENOG4105ENX hydrolase AS86_2827 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) AS86_2838 ENOG4105CEY Amp-dependent synthetase and ligase AS86_284 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS86_2840 ENOG4105DF9 Lipoate-protein, ligase AS86_2841 ENOG4108RQ5 Beta-lactamase domain-containing protein AS86_2842 ENOG4106AXD AS86_2848 ENOG4105ECB domain protein AS86_285 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AS86_2854 ENOG4105C1Q protoporphyrinogen oxidase AS86_2855 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AS86_2857 ENOG4105BZ4 penicillin-binding protein AS86_2858 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AS86_2859 ENOG4105CKV Membrane AS86_2860 ENOG410905X membrane-flanked domain protein AS86_2868 ENOG4105CKV Membrane AS86_2869 ENOG410905X membrane-flanked domain protein AS86_2875 ENOG4105K59 histidine triad (HIT) protein AS86_2880 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS86_2881 ENOG4105EEM helicase AS86_2885 ENOG4105EMN RNA polymerase sigma factor AS86_2889 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AS86_2892 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AS86_2893 ENOG4105D7V transposase AS86_2894 ENOG41067QW Transcriptional regulator AS86_2895 ENOG4105F0F Oxalate decarboxylase AS86_29 ENOG4105DZP Membrane-associated zinc metalloprotease AS86_290 ENOG4105W8X HesB YadR YfhF-family protein AS86_2900 ENOG4108MUZ hydrolase AS86_2905 ENOG410829K Lysine exporter protein (Lyse ygga) AS86_2908 ENOG4106D4I domain protein AS86_2909 ENOG4107VRP DNA repair exonuclease AS86_291 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AS86_2913 ENOG4107QHE Choloylglycine hydrolase AS86_2915 ENOG4105D7V transposase AS86_292 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AS86_2922 ENOG4105BZU Histidine kinase AS86_2923 ENOG4105BZU Histidine kinase AS86_2924 ENOG4108MJI response regulator AS86_2926 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS86_2928 ENOG4105WN5 stage II sporulation protein AS86_294 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_295 ENOG4105C0H protease AS86_2952 ENOG4105CMT Dihydroxyacetone kinase AS86_2954 ENOG4105CMT Dihydroxyacetone kinase AS86_2956 ENOG4105WAB arsR family transcriptional regulator AS86_2957 ENOG4105F27 Major Facilitator AS86_2959 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AS86_296 ENOG4105K4P CoA-binding domain protein AS86_297 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS86_2970 ENOG4105F6J Alpha beta hydrolase fold AS86_2985 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS86_299 ENOG4105D9R oxidoreductase AS86_2990 ENOG4105CDU Replicative dna helicase AS86_2994 ENOG4105C4R Atp-dependent dna helicase AS86_3003 ENOG4108MRH transcriptional regulatory protein AS86_3005 ENOG4105CSH Transporter AS86_3013 ENOG4105GMB type VI secretion system effector, hcp1 family AS86_3015 ENOG4108IBT Inherit from COG: transposase AS86_3016 ENOG4108IBT Inherit from COG: transposase AS86_3020 ENOG4105DQ6 Transposase AS86_3027 ENOG4107SFI Major Facilitator superfamily AS86_3028 ENOG4105D06 uba thif-type nad fad binding protein AS86_303 ENOG4105CIG ABC transporter AS86_3031 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AS86_3038 ENOG4108JQ7 (ABC) transporter AS86_3040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS86_3043 ENOG4105CIF Ornithine Cyclodeaminase AS86_3048 ENOG4105DER m42 family AS86_305 ENOG4105EMN RNA polymerase sigma factor AS86_3052 ENOG4105CGU Enoyl-CoA hydratase AS86_3057 ENOG4105CHH sulfate transporter AS86_3059 ENOG4105CEY Amp-dependent synthetase and ligase AS86_3060 ENOG4105D4P Coproporphyrinogen iii oxidase AS86_3061 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS86_3062 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein AS86_3066 ENOG4107FQX Alpha-acetolactate decarboxylase AS86_307 ENOG4108KGH TRANSCRIPTIONal AS86_3073 ENOG410839P AS86_3076 ENOG4105CDA abc transporter atp-binding protein AS86_3077 ENOG4105DRP amino acid AbC transporter AS86_3079 ENOG4105BZ1 (ABC) transporter AS86_308 ENOG4107QJT sodium dicarboxylate symporter AS86_3080 ENOG4105BZ1 (ABC) transporter AS86_3081 ENOG4105C26 Dehydrogenase AS86_3082 ENOG4105D5Q Arginine ornithine antiporter AS86_3084 ENOG4105CH6 catalase AS86_3085 ENOG4107RKG DJ-1/PfpI family AS86_3093 ENOG4105KPY Small multidrug resistance protein AS86_3094 ENOG4105W1Y Transcriptional regulator AS86_3095 ENOG4105UBK short-chain dehydrogenase reductase AS86_3097 ENOG4108YXU transcriptional regulator AsnC family AS86_31 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AS86_3105 ENOG4106KNT transcriptional regulator AS86_3107 ENOG4107RWR Sodium hydrogen exchanger AS86_3108 ENOG4105CUB amino acid AS86_3115 ENOG4107T5V SNARE associated Golgi AS86_3122 ENOG4105WEF catalase AS86_3128 ENOG4105C19 ABC transporter AS86_3129 ENOG4107RBB ABC transporter, permease AS86_3130 ENOG41069ER domain protein AS86_3135 ENOG4105VZJ PTS System AS86_3136 ENOG4105VCP PTS System AS86_3137 ENOG4105EMD TRANSCRIPTIONal AS86_3142 ENOG4108KGH TRANSCRIPTIONal AS86_3144 ENOG41087NI Sulfite exporter TauE/SafE AS86_3145 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AS86_3147 ENOG4105VFE sira family AS86_3148 ENOG4105VFE sira family AS86_3149 ENOG4107TPS domain protein AS86_3150 ENOG4105VFE sira family AS86_3151 ENOG4105XTG Pfam:DUF156 AS86_3153 ENOG4108TCS Glutamyl endopeptidase AS86_3156 ENOG4105ED1 spovr family AS86_3157 ENOG4107Y03 Nitroreductase AS86_3161 ENOG4108B31 Spore germination protein AS86_3165 ENOG4105K63 Thioredoxin AS86_3168 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AS86_3170 ENOG4105C7N Xanthine uracil vitamin C permease AS86_3173 ENOG4108INS Transcriptional regulator AS86_3182 ENOG4105DWF phosphomethylpyrimidine kinase AS86_3183 ENOG4105D06 uba thif-type nad fad binding protein AS86_3186 ENOG41080HI glycine oxidase AS86_3187 ENOG4108VEU Thiamine monophosphate synthase AS86_3189 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AS86_3191 ENOG4105ETU transcriptional activator (TenA AS86_3195 ENOG41080XQ Signal transduction protein with cbs domains AS86_322 ENOG4105E1K spore germination protein AS86_3224 ENOG4105E2Z phosphate ABC transporter (Permease AS86_3225 ENOG4105C8U phosphate abc transporter AS86_3226 ENOG4105CVA phosphate AS86_3227 ENOG4105CE1 Ferrous iron transport protein b AS86_3228 ENOG4105CE1 Ferrous iron transport protein b AS86_3229 ENOG4105CE1 Ferrous iron transport protein b AS86_3230 ENOG4108NHD germination protein AS86_3233 ENOG4105E1V na solute symporter AS86_3234 ENOG4106CAD Protein of unknown function (DUF3311) AS86_3238 ENOG4105E2S oxidase) subunit II AS86_3239 ENOG4105BZ9 Cytochrome C oxidase, subunit I AS86_3244 ENOG4105MA6 gCN5-related N-acetyltransferase AS86_3247 ENOG4105C7N Xanthine uracil vitamin C permease AS86_3248 ENOG4105C85 amino acid AS86_325 ENOG4108JB9 formate dehydrogenase AS86_3253 ENOG4105DUX Transporter AS86_3256 ENOG4107D63 AS86_3257 ENOG4105VZ8 Transcriptional regulator AS86_3258 ENOG41069ER domain protein AS86_3259 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS86_3260 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AS86_3265 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) AS86_3273 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AS86_3274 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AS86_3275 ENOG4105CNN ABC, transporter AS86_3276 ENOG4105C2J ABC transporter AS86_3278 ENOG4108RVA ribokinase AS86_3279 ENOG4105ETE Transcriptional regulator (LacI family AS86_3280 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS86_3281 ENOG41067TZ transcriptional regulator, MarR family AS86_3282 ENOG4105CXY transporter AS86_3284 ENOG41068KF Universal stress protein AS86_3285 ENOG4105CHH sulfate transporter AS86_3290 ENOG4105BZU Histidine kinase AS86_3291 ENOG4105NAE bifunctional deaminase-reductase domain protein AS86_3292 ENOG4105D29 Helix-turn-helix type 11 domain protein AS86_3294 ENOG4105GFR rna polymerase sigma factor AS86_3297 ENOG4108IQI permease AS86_3298 ENOG4105DRP amino acid AbC transporter AS86_3299 ENOG4105EAD ABC transporter AS86_33 ENOG4105CHV Transcription elongation factor NusA AS86_3300 ENOG4105CT1 (ABC) transporter AS86_3301 ENOG4105CDA abc transporter atp-binding protein AS86_3302 ENOG4105BZG amino acid carrier protein AS86_3303 ENOG4105CRN Aminoglycoside phosphotransferase AS86_3304 ENOG4105E1K spore germination protein AS86_3308 ENOG4105CG3 alpha amylase, catalytic region AS86_3309 ENOG4105C5Y PTS System AS86_3310 ENOG4107414 GntR family transcriptional regulator AS86_3311 ENOG4105D5Q Arginine ornithine antiporter AS86_3312 ENOG4105BZU Histidine kinase AS86_3314 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS86_3315 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AS86_3316 ENOG4107T89 von Willebrand factor, type A AS86_3318 ENOG4105EXW epimerase dehydratase AS86_3321 ENOG4105E0A ABC, transporter AS86_3322 ENOG4108IHU transport system permease protein AS86_3323 ENOG4105DQ5 transport system permease protein AS86_3324 ENOG4108MES Periplasmic binding protein AS86_3325 ENOG4105DUX Transporter AS86_3328 ENOG4105DAA L-lactate AS86_3329 ENOG4108IJ0 Aspartate ammonia-lyase AS86_3330 ENOG4105C37 (CBS) domain AS86_3331 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AS86_3332 ENOG4105D9N nucleoside AS86_3333 ENOG4108KGH TRANSCRIPTIONal AS86_3334 ENOG41073R8 VanW family AS86_3341 ENOG4105DAP Nicotinate phosphoribosyltransferase AS86_3342 ENOG4105C59 p-type ATPase AS86_3344 ENOG4105CUB amino acid AS86_3348 ENOG4108JB9 formate dehydrogenase AS86_3349 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AS86_3355 ENOG4105BZU Histidine kinase AS86_3359 ENOG4108UZ3 Transporter AS86_336 ENOG4108NF7 phage-type endonuclease AS86_3361 ENOG4105C6K Malic enzyme AS86_3363 ENOG4108MRH transcriptional regulatory protein AS86_3368 ENOG4105US7 Histidine kinase AS86_3369 ENOG4108STX response regulator AS86_337 ENOG4108PNI recT protein AS86_3370 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AS86_3371 ENOG4105BZ7 extracellular solute-binding protein family 1 AS86_3372 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AS86_3373 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AS86_3374 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS86_3375 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AS86_3380 ENOG4105D4T Citrate transporter AS86_3381 ENOG4108V9W transcriptional regulatory protein AS86_3382 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AS86_3384 ENOG4105DZ6 Band 7 protein AS86_3387 ENOG4105C94 Transporter AS86_3390 ENOG4105CYN Serine protein kinase AS86_3392 ENOG4105BZU Histidine kinase AS86_3393 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AS86_3395 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AS86_3397 ENOG4108R9S DSBA oxidoreductase AS86_3398 ENOG4108JQC penicillin-binding protein 1A AS86_34 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AS86_3425 ENOG4105G5W regulator Fur family AS86_3426 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS86_3430 ENOG4108IUW ABC transporter AS86_3432 ENOG4105CBC glutamate synthase AS86_3433 ENOG4107NBY Membrane AS86_3434 ENOG4105BZ1 (ABC) transporter AS86_3438 ENOG4106BXE AS86_3439 ENOG4105CEN a g-specific adenine glycosylase AS86_3440 ENOG41067AE Membrane-bound metal-dependent hydrolase AS86_3446 ENOG4105ECP epimerase AS86_3447 ENOG4105CI2 imidazolone-5-propionate hydrolase AS86_3451 ENOG4105F1A Pyruvate formate-lyase AS86_3453 ENOG4105CKK Glycosyl transferase, family 2 AS86_3454 ENOG4105C3I Nad-dependent epimerase dehydratase AS86_3455 ENOG4107QQG Dehydrogenase AS86_3456 ENOG4105CKK Glycosyl transferase, family 2 AS86_3459 ENOG4108A04 Beta-lactamase AS86_3461 ENOG4105CSV Glutaminase AS86_3467 ENOG4108IQI permease AS86_3469 ENOG4108JUB Transcriptional regulator AS86_347 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS86_3471 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AS86_3473 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AS86_3480 ENOG4105UPD Calcium Proton AS86_3481 ENOG410606W general stress protein AS86_3484 ENOG4107ZTW SNARE associated Golgi AS86_3488 ENOG4108IPJ Membrane AS86_3489 ENOG4105C59 p-type ATPase AS86_3490 ENOG4107U9T Pfam:Ribonuclease_BN AS86_3492 ENOG4105KJF protein tyrosine phosphatase AS86_3493 ENOG41068PA UPF0435 protein AS86_3496 ENOG4108TTB tellurium resistance protein AS86_3497 ENOG4107TS3 membrane protein, TerC AS86_3498 ENOG4106FN3 tellurium resistance protein AS86_3499 ENOG4106FN3 tellurium resistance protein AS86_35 ENOG4105VHM ribosomal protein AS86_350 ENOG4105WXW Antirepressor AS86_3500 ENOG4108N0M stress protein AS86_3506 ENOG4105DEU major facilitator superfamily AS86_3509 ENOG41062JF Transcriptional regulator AS86_3515 ENOG4105C5H ABC transporter AS86_3517 ENOG4105D2X ABC transporter substrate-binding protein AS86_3518 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AS86_3522 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AS86_3525 ENOG4105C9U ATP-dependent DNA helicase RecQ AS86_3528 ENOG4105CI1 PTS System AS86_3530 ENOG4105DNP FAD linked oxidase domain protein AS86_3532 ENOG4108W63 CRP FNR family transcriptional regulator AS86_3533 ENOG4105C5B carbamate kinase AS86_3535 ENOG4105DBV ornithine carbamoyltransferase AS86_3538 ENOG4105C8Q Methyl-accepting chemotaxis AS86_3539 ENOG4105CDA abc transporter atp-binding protein AS86_3540 ENOG4105EAB amino acid AbC transporter AS86_3541 ENOG4105E5Q amino acid AbC transporter AS86_3544 ENOG4105D2S major facilitator superfamily AS86_3545 ENOG410756H nucleotidyltransferase AS86_3549 ENOG4105BZU Histidine kinase AS86_355 ENOG4108C33 Resolvase AS86_3552 ENOG4106UIA AS86_3553 ENOG4106UIA AS86_3557 ENOG4108V5C ABC transporter AS86_3558 ENOG4105DQ5 transport system permease protein AS86_3559 ENOG4105EHG Permease protein AS86_3561 ENOG4105DQ6 Transposase AS86_3562 ENOG4107W7X Aldolase AS86_3563 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AS86_3564 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AS86_3565 ENOG4105D3R alkyl hydroperoxide reductase AS86_3570 ENOG4105DFD Na H antiporter AS86_3571 ENOG4105DTQ mandelate racemase muconate lactonizing AS86_3575 ENOG4108W15 Protein of unknown function (DUF1456) AS86_3577 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AS86_3578 ENOG4105D9N nucleoside AS86_3584 ENOG4105KPY Small multidrug resistance protein AS86_3585 ENOG4105C26 Dehydrogenase AS86_3587 ENOG4108JPW Aminotransferase AS86_3589 ENOG4105CBD Diacylglycerol kinase AS86_3593 ENOG4107I77 yiaA/B two helix domain AS86_3594 ENOG410834F Transcriptional regulator AS86_3598 ENOG4105D01 (LipO)protein AS86_3599 ENOG4108UMI ABC transporter, permease AS86_3600 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS86_3601 ENOG4108W2Y isochorismatase AS86_3606 ENOG4105C4R Atp-dependent dna helicase AS86_3611 ENOG4105C12 Phosphoribosylglycinamide synthetase AS86_3613 ENOG4108V3E phosphoribosylglycinamide formyltransferase AS86_3618 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AS86_3620 ENOG4105C83 adenylosuccinate lyase AS86_3621 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AS86_3622 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AS86_3628 ENOG410631K Membrane AS86_3633 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS86_3644 ENOG4107ZXU DSBA oxidoreductase AS86_3650 ENOG4105BZU Histidine kinase AS86_3652 ENOG4105C7N Xanthine uracil vitamin C permease AS86_3654 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AS86_3657 ENOG4106128 DNA-binding helix-turn-helix protein AS86_3659 ENOG4106BHR ftsk SpoIIIE family protein AS86_3669 ENOG4108IBT Inherit from COG: transposase AS86_3687 ENOG4108TYN CAAX amino terminal protease family protein AS86_3690 ENOG4105C5H ABC transporter AS86_3691 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AS86_3692 ENOG410801F ribosomal-protein-alanine acetyltransferase AS86_3693 ENOG41072GX Peptidase M22 Glycoprotease AS86_3694 ENOG4105K8N protein family UPF0079, ATPase AS86_37 ENOG4105W7A Protein of unknown function (DUF503) AS86_3715 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AS86_3717 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AS86_3718 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AS86_3723 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AS86_3724 ENOG4105CPF Cell wall formation (By similarity) AS86_3725 ENOG4108SC4 )-transporter AS86_3726 ENOG4105CUB amino acid AS86_3728 ENOG4105ERH Fumarylacetoacetate hydrolase AS86_3729 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AS86_3734 ENOG410667J hydrolase AS86_3735 ENOG4108JQ7 (ABC) transporter AS86_3736 ENOG4105C3U ABC transporter AS86_3737 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS86_3739 ENOG4105DEF Extracellular solute-binding protein, family 5 AS86_3741 ENOG4105C5H ABC transporter AS86_3745 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AS86_3749 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AS86_375 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AS86_3753 ENOG4105F6E Acyl-transferase AS86_3759 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AS86_3760 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AS86_3761 ENOG4105E0C molybdate abc transporter AS86_3767 ENOG4108J59 Extracellular solute-binding protein, family 5 AS86_3771 ENOG4108JQ7 (ABC) transporter AS86_3772 ENOG4105C3U ABC transporter AS86_3773 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS86_3774 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS86_3778 ENOG4105C2C drug resistance transporter, Bcr CflA AS86_3781 ENOG4105IQ5 FAD linked oxidase domain protein AS86_3783 ENOG4105CB2 alcohol dehydrogenase AS86_3784 ENOG4105D01 (LipO)protein AS86_3785 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS86_3786 ENOG4108UMI ABC transporter, permease AS86_3787 ENOG4108PSK reductase AS86_3791 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AS86_3793 ENOG4107U5W ybbr family AS86_3794 ENOG4105C8B TIGR00159 family AS86_3811 ENOG4108NMV polysaccharide deacetylase AS86_3814 ENOG4105D1F ATP-binding protein AS86_3819 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AS86_3820 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AS86_3821 ENOG4108JJB ABC transporter AS86_3822 ENOG4108JJB ABC transporter AS86_3827 ENOG41067V7 50S ribosomal protein L36 AS86_3829 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AS86_383 ENOG4108JB9 formate dehydrogenase AS86_3831 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AS86_3836 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AS86_385 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AS86_3857 ENOG4105XPM ribosomal protein AS86_3858 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AS86_386 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AS86_3860 ENOG4107Y49 methyltransferase AS86_3865 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AS86_3867 ENOG4105QIV RNA polymerase AS86_3868 ENOG4105M0M Tetracycline resistance protein AS86_3869 ENOG4105C2N RNA methyltransferase TrmH family group 3 AS86_3872 ENOG4105D7W serine acetyltransferase AS86_3876 ENOG4105CTP PilT protein domain protein AS86_3878 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AS86_388 ENOG4105TMB Formate nitrite transporter AS86_3881 ENOG4108Z0C Uvrb UvrC protein AS86_389 ENOG4105D06 uba thif-type nad fad binding protein AS86_390 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS86_3903 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AS86_3905 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AS86_3906 ENOG4105KRF dihydroneopterin aldolase AS86_3907 ENOG4105EEI dihydropteroate synthase AS86_3908 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AS86_3909 ENOG4105DDQ anthranilate synthase AS86_391 ENOG4108ZAF Molybdopterin AS86_3910 ENOG4105CRQ synthase (Component I) AS86_3911 ENOG4105C6T cysteine synthase AS86_3914 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AS86_3915 ENOG4108UGV hypoxanthine phosphoribosyltransferase AS86_3916 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AS86_3920 ENOG41060GV RNA binding s1 domain protein AS86_3923 ENOG4105VYY sporulation protein yabp AS86_3924 ENOG41082I2 s4 domain protein AS86_3925 ENOG4108IY2 MazG family AS86_3927 ENOG4108M14 stage v sporulation protein t AS86_3928 ENOG4108JA2 transcriptioN-repair coupling factor AS86_393 ENOG4105D1F ATP-binding protein AS86_3930 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AS86_3931 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AS86_3934 ENOG4105KME endoribonuclease L-psp AS86_3935 ENOG4105DFT pur operon repressor AS86_3938 ENOG4105W42 Veg protein AS86_3939 ENOG4105XFA sporulation peptidase YabG AS86_3941 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AS86_3942 ENOG4105F8V Hydrolase, tatD family AS86_3943 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AS86_3944 ENOG4105KRN Transcriptional regulator, abrb family AS86_3945 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AS86_3947 ENOG41060K3 Methyltransferase AS86_3949 ENOG4105MA4 psp1 domain protein AS86_3950 ENOG4105FA2 dna polymerase iii AS86_3952 ENOG4105CXN decarboxylase AS86_396 ENOG410696E Membrane AS86_3960 ENOG41067KS pro-sigma K processing AS86_3964 ENOG4105C6E dna polymerase iii AS86_3965 ENOG4108Z6B deaminase AS86_3966 ENOG4105GTG Isochorismatase AS86_3968 ENOG4105ZMH deoxynucleoside kinase AS86_397 ENOG4105FR1 rard protein AS86_3975 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AS86_3983 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS86_3986 ENOG410848D S4 domain protein YaaA AS86_3987 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AS86_399 ENOG4105EWU Squalene--hopene cyclase AS86_3991 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AS86_3993 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AS86_3997 ENOG4107QJE Chromosome Partitioning Protein AS86_3998 ENOG4105FA0 parb-like partition protein AS86_3999 ENOG4108ZDA Sporulation protein YyaC AS86_40 ENOG4105DTN riboflavin biosynthesis protein ribF AS86_4000 ENOG4105D8X mechanosensitive ion channel AS86_4001 ENOG4105VDK protein, conserved in bacteria AS86_4002 ENOG4105C3G gtp-binding protein AS86_4004 ENOG4108UUM single-stranded DNA-binding protein AS86_4006 ENOG4108XMW Membrane AS86_4007 ENOG4105BZR domain protein AS86_4009 ENOG4105CDU Replicative dna helicase AS86_401 ENOG4105CHR reductase AS86_4010 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AS86_4015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_4016 ENOG4105BZU Histidine kinase AS86_4019 ENOG4105Q2H domain protein AS86_402 ENOG4105C26 Dehydrogenase AS86_4020 ENOG4105C0H protease AS86_4023 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AS86_4034 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AS86_4036 ENOG4107Y5K Resolvase AS86_404 ENOG4108IA2 Sodium pantothenate symporter AS86_4046 ENOG4107Y5K Resolvase AS86_4048 ENOG4105DQ6 Transposase AS86_4051 ENOG4105DPN Oligoendopeptidase f AS86_4052 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) AS86_4053 ENOG4105C1J atp-dependent rna helicase AS86_4055 ENOG4108UT2 hemolysin iii AS86_4056 ENOG4105CMR udp-glucose 4-epimerase AS86_4059 ENOG4105IW1 AmiS UreI transporter AS86_4061 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS86_4064 ENOG4107RGD Major Facilitator superfamily AS86_4065 ENOG4108HRK Histidine kinase AS86_4066 ENOG4108NEV two component transcriptional regulator, LytTR family AS86_4069 ENOG4106F5Q Membrane AS86_407 ENOG4106IQC argininosuccinate lyase AS86_4070 ENOG4105E0X reductase AS86_4072 ENOG41067SE Tetr family transcriptional regulator AS86_4073 ENOG4105C5H ABC transporter AS86_4074 ENOG4108IG5 Transcriptional regulator AS86_4076 ENOG4105CKK Glycosyl transferase, family 2 AS86_4077 ENOG4105EJV Membrane AS86_4079 ENOG4105K64 Glycosyl transferase, family 2 AS86_4082 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AS86_4083 ENOG4108S4H thioesterase Superfamily protein AS86_4085 ENOG4106YBV Methyl-accepting chemotaxis AS86_4086 ENOG4105EN6 Membrane AS86_4088 ENOG4105CG5 Glycosyl transferase (Group 1 AS86_409 ENOG410904N short-chain dehydrogenase reductase AS86_4090 ENOG41079KZ Major Facilitator Superfamily AS86_4091 ENOG4105DY9 regulatoR AS86_4092 ENOG4105D22 carbon starvation protein AS86_4093 ENOG4105VCD cytoplasmic protein AS86_4094 ENOG4105BZU Histidine kinase AS86_4095 ENOG4105DWF phosphomethylpyrimidine kinase AS86_4096 ENOG4105BZU Histidine kinase AS86_4097 ENOG4105WH1 Two component transcriptional regulator luxr family AS86_4099 ENOG4108Y4K DNA-binding transcriptional activator AS86_4104 ENOG4105D6E homoserine dehydrogenase AS86_4107 ENOG41090WU lipolytic protein G-D-S-L family AS86_4108 ENOG4105CJ1 ABC, transporter AS86_4109 ENOG4108TU7 Inherit from COG: (ABC) transporter AS86_4111 ENOG4105VCH membrane AS86_4112 ENOG410667J hydrolase AS86_4114 ENOG4107SVH Potassium channel protein AS86_4118 ENOG4108VKI Cell wall hydrolase AS86_4120 ENOG4107UEZ chlorite dismutase AS86_4121 ENOG4108IJ2 phosphate acetyltransferase AS86_4122 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AS86_4123 ENOG4108VCI transcription factor, rsfa family AS86_4125 ENOG4105DQ5 transport system permease protein AS86_4126 ENOG4105EHG Permease protein AS86_4127 ENOG4105E0A ABC, transporter AS86_4128 ENOG4108MES Periplasmic binding protein AS86_4129 ENOG4105DCI Phosphohydrolase AS86_413 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AS86_4130 ENOG41069HH 4-oxalocrotonate tautomerase AS86_4131 ENOG4108Z4T Peptidase M50 AS86_4132 ENOG4108XFG YwhD family AS86_4133 ENOG4105BZ4 penicillin-binding protein AS86_4134 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS86_4135 ENOG4107SWG transcriptional regulator MERR family AS86_4136 ENOG4105DXB Major Facilitator superfamily AS86_4138 ENOG4105CYW agmatinase AS86_4142 ENOG410684U Domain of unknown function (DUF1934) AS86_4144 ENOG4105EMN RNA polymerase sigma factor AS86_4148 ENOG4105IIU Aminopeptidase AS86_4150 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AS86_4151 ENOG4108M15 ABC transporter AS86_4152 ENOG4105KCT ABC transporter AS86_4153 ENOG4105BZU Histidine kinase AS86_4155 ENOG4105D4Y metalloprotease AS86_4158 ENOG4105BZU Histidine kinase AS86_4169 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) AS86_417 ENOG4105VEQ Cold shock protein AS86_4170 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AS86_4177 ENOG41067QW Transcriptional regulator AS86_4178 ENOG4105DF6 Fe-S oxidoreductase AS86_4180 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AS86_4181 ENOG4105C1G acyl-Coa dehydrogenase AS86_4182 ENOG4105C1G acyl-Coa dehydrogenase AS86_4189 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AS86_4190 ENOG4105CBT Fructose-1,6-bisphosphatase AS86_4191 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AS86_4194 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AS86_4195 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AS86_4196 ENOG4108ZXQ stage ii sporulation protein r AS86_4198 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AS86_4203 ENOG4105DQ6 Transposase AS86_4204 ENOG4107XC4 flavin reductase domain protein, FMN-binding AS86_4205 ENOG4108VGI doxx family AS86_4208 ENOG4108YZG isomerase AS86_4209 ENOG4108UIC UPF0340 protein AS86_421 ENOG4108R1P AS86_4213 ENOG41062M3 atp synthase AS86_4214 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AS86_4224 ENOG4105BZU Histidine kinase AS86_4225 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AS86_4227 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AS86_4228 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AS86_423 ENOG41073R8 VanW family AS86_4233 ENOG4105D65 subunit l AS86_4234 ENOG4105C8S subunit m AS86_4235 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AS86_4236 ENOG4106778 Protein of unknown function (DUF1146) AS86_4240 ENOG4105DY9 regulatoR AS86_4243 ENOG4105FRN stage II sporulation protein AS86_4244 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AS86_4247 ENOG4107YJ4 chain length determinant protein AS86_4248 ENOG4105HTX biosynthesis protein AS86_4249 ENOG4107YJ4 chain length determinant protein AS86_425 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AS86_4250 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AS86_4251 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AS86_4252 ENOG4105D3Q Sugar transferase AS86_4255 ENOG4105CPK Glycosyl transferase (Group 1 AS86_4257 ENOG4105C6Y Udp-glucose 6-dehydrogenase AS86_4258 ENOG4105CMR udp-glucose 4-epimerase AS86_4259 ENOG4108KGH TRANSCRIPTIONal AS86_4261 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_4262 ENOG4105BZU Histidine kinase AS86_4265 ENOG4105CXY transporter AS86_4269 ENOG4105C19 ABC transporter AS86_427 ENOG4105KT7 mgtC SapB transporter AS86_4270 ENOG4107RBB ABC transporter, permease AS86_4272 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS86_4278 ENOG4105C0D helicase AS86_4279 ENOG4105KBK Zinc finger, swim domain protein AS86_4284 ENOG41069ER domain protein AS86_4285 ENOG4105C94 Transporter AS86_4287 ENOG4107R8N Glycosyl transferase, family 2 AS86_429 ENOG4105BZU Histidine kinase AS86_4293 ENOG4105E0M Sulfatase AS86_4295 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AS86_4297 ENOG4105DAA L-lactate AS86_4304 ENOG4107RSM transcriptional regulator AS86_4305 ENOG4105ECB domain protein AS86_4309 ENOG4105VZJ PTS System AS86_4311 ENOG4105VCP PTS System AS86_4312 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AS86_4313 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AS86_4315 ENOG4105CK1 PTS System AS86_4316 ENOG4105VCP PTS System AS86_4317 ENOG4105F8D glycoside hydrolase family 4 AS86_4321 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AS86_4323 ENOG4105ESV Glycosyl transferase, family 4 AS86_4324 ENOG4105C6Y Udp-glucose 6-dehydrogenase AS86_4325 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AS86_4326 ENOG4108KGH TRANSCRIPTIONal AS86_4327 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AS86_4329 ENOG4105KVH Transcriptional regulator AS86_433 ENOG4107DUR UPF0457 protein AS86_4332 ENOG41081UC Inherit from COG: Competence protein AS86_4333 ENOG4105VEQ Cold shock protein AS86_4334 ENOG4105MS2 ribosomal subunit Interface protein AS86_4336 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AS86_4338 ENOG4105CAK Cell division ATP-binding protein ftsE AS86_4339 ENOG4105CRP Part of the ABC transporter FtsEX involved in AS86_434 ENOG4108VXD carboxy-peptidase AS86_4340 ENOG4105CN1 protease AS86_4342 ENOG4105BZ1 (ABC) transporter AS86_4344 ENOG4105C5H ABC transporter AS86_4345 ENOG4108WS4 fmn reductase AS86_4347 ENOG4105DUM transcriptional regulator, lysR family AS86_4348 ENOG4105HMI Membrane AS86_4351 ENOG4107TXC Transcriptional regulator AS86_4355 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS86_4357 ENOG41086DT Membrane protein of unknown function AS86_436 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity AS86_4361 ENOG4108S4C acetyltransferase AS86_4363 ENOG4105C3M thioredoxin reductase AS86_4365 ENOG4108Z4K mutator MutT protein AS86_4367 ENOG4105CHW UPF0052 protein AS86_4369 ENOG4105KRI phosphocarrier protein (HPr AS86_4370 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AS86_4371 ENOG4108QY0 Membrane AS86_4374 ENOG4105CZ3 stage V sporulation protein ad AS86_4375 ENOG41090VF Stage v sporulation protein ac AS86_4379 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS86_4389 ENOG41067MG lrgb family AS86_4390 ENOG4105XZU Preprotein translocase, subunit SecG AS86_4392 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AS86_4397 ENOG4105CM4 permease protein AS86_4398 ENOG4108IPW abc transporter atp-binding protein AS86_44 ENOG4105C1V Peptidase, M16 AS86_4401 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AS86_4402 ENOG4108V2W Carbonate dehydratase AS86_4406 ENOG4108W2Y isochorismatase AS86_4408 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AS86_4410 ENOG4108MK9 spermidine N(1)-acetyltransferase AS86_4411 ENOG4105C5H ABC transporter AS86_4415 ENOG4105WMR Protein CrcB homolog AS86_4418 ENOG4105C8Q Methyl-accepting chemotaxis AS86_4420 ENOG4105D4A Cell wall formation (By similarity) AS86_4421 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AS86_4424 ENOG4105KVH Transcriptional regulator AS86_4425 ENOG4105F27 Major Facilitator AS86_4426 ENOG4105CV8 reductase AS86_4429 ENOG4108RYK Nad-dependent epimerase dehydratase AS86_443 ENOG4108IMY Transcriptional regulator AS86_4432 ENOG4105D9N nucleoside AS86_4433 ENOG4105D9N nucleoside AS86_4435 ENOG41090A1 ferritin AS86_4437 ENOG4108URH decarboxylase AS86_4440 ENOG4108RMU ferritin dps family protein AS86_4442 ENOG4105NCW Trka-c domain protein AS86_4443 ENOG4107S91 Sodium hydrogen exchanger AS86_4444 ENOG4107T5V SNARE associated Golgi AS86_4447 ENOG4105C2I pirin domain protein AS86_4448 ENOG4105D4Y metalloprotease AS86_4449 ENOG4105DQ6 Transposase AS86_4451 ENOG4105VG1 fes assembly suf system protein AS86_4452 ENOG4105C8Q Methyl-accepting chemotaxis AS86_4453 ENOG4105C8Q Methyl-accepting chemotaxis AS86_4458 ENOG4105BZU Histidine kinase AS86_4459 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_4460 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AS86_4462 ENOG4107ZTW SNARE associated Golgi AS86_4469 ENOG4107AYK membrAne AS86_4471 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AS86_4474 ENOG4107R7I amino acid AS86_4475 ENOG4108SUT Major Facilitator Superfamily AS86_4478 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS86_4482 ENOG4105DZ1 carboxypeptidase AS86_4485 ENOG4105CHU acetyl-coa acetyltransferase AS86_4486 ENOG4105C1G acyl-Coa dehydrogenase AS86_4487 ENOG4108W8B Beta-lactamase domain protein AS86_4490 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS86_4494 ENOG41080E8 Transcriptional regulator, Spx MgsR family AS86_4499 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS86_4500 ENOG4108UMI ABC transporter, permease AS86_4501 ENOG4105D01 (LipO)protein AS86_4502 ENOG4105D01 (LipO)protein AS86_4503 ENOG4105C3K feS assembly ATPase SufC AS86_4504 ENOG4105JRK feS assembly protein SufD AS86_4505 ENOG4105C9B Cysteine desulfurase AS86_4506 ENOG4108UNV SUF system FeS assembly protein, NifU family AS86_4507 ENOG4105DIW FeS assembly protein SUFB AS86_4508 ENOG4107R8B 5'-nucleotidase AS86_4509 ENOG4105KZD Domain of unknown function (DUF1805) AS86_4510 ENOG4108YTE sporulation protein YunB AS86_4511 ENOG4105FAA peptidase M23 AS86_4516 ENOG41090T1 Membrane AS86_4517 ENOG4107TXC Transcriptional regulator AS86_4518 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AS86_4519 ENOG4105MMD transcriptional regulator AS86_4522 ENOG4105CBT Fructose-1,6-bisphosphatase AS86_4525 ENOG4105D4U had-superfamily hydrolase, subfamily iia AS86_4526 ENOG4105DYS nad(p)h dehydrogenase (quinone) AS86_4528 ENOG4105DAX Pfam:DUF2983 AS86_4532 ENOG4108W5N phosphatidylglycerophosphatase a AS86_4535 ENOG41083MR nifu domain-containing protein AS86_4544 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AS86_4545 ENOG4105C4B ABC transporter, permease AS86_4546 ENOG4108JJA ABC, transporter AS86_4550 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AS86_4556 ENOG4105EWC Purine nucleoside phosphorylase AS86_4561 ENOG4105CEP NADH dehydrogenase AS86_4564 ENOG41069ER domain protein AS86_4568 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AS86_4571 ENOG4105KA0 thioesterase Superfamily protein AS86_4572 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AS86_4575 ENOG4107R3E Citrate transporter AS86_4577 ENOG4105Y38 Kinase-associated protein B AS86_4580 ENOG4105C87 Aminotransferase class I and II AS86_4582 ENOG4108MUZ hydrolase AS86_4583 ENOG4105C5I Dehydrogenase AS86_4584 ENOG4108ZB6 transcriptional regulator AsnC family AS86_4585 ENOG4105CHM Aminotransferase AS86_4587 ENOG4105WG9 Conserved Protein AS86_4589 ENOG4107PBV potassium channel AS86_4591 ENOG4105KT7 mgtC SapB transporter AS86_46 ENOG4105E35 Dipicolinate synthase subunit A AS86_4621 ENOG4108Q5F Tetr family transcriptional regulator AS86_4622 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS86_4625 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AS86_4634 ENOG4105VEQ Cold shock protein AS86_4636 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AS86_4637 ENOG4105E4F Isochorismate synthase AS86_4639 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AS86_4640 ENOG4108IPT Naphthoate synthase AS86_4642 ENOG4105DTQ mandelate racemase muconate lactonizing AS86_4646 ENOG41069H0 dihydroorotase EC 3.5.2.3 AS86_4650 ENOG4105FDP GntR family transcriptional regulator AS86_4651 ENOG4105C6Z Gluconate AS86_4660 ENOG41082BM Transcriptional regulator, arsr family AS86_4662 ENOG4105CJ1 ABC, transporter AS86_4664 ENOG41086D8 Transcriptional regulator AS86_4665 ENOG4105C19 ABC transporter AS86_4668 ENOG4107ZTW SNARE associated Golgi AS86_4670 ENOG4105BZU Histidine kinase AS86_4681 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AS86_4682 ENOG4108UGV hypoxanthine phosphoribosyltransferase AS86_4687 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_4688 ENOG4105BZU Histidine kinase AS86_4689 ENOG4105N67 Proton-coupled thiamine transporter YuaJ AS86_4694 ENOG41087YS Phage shock protein A AS86_47 ENOG4108S0H Dipicolinic acid synthetase, b subunit AS86_4703 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AS86_4704 ENOG4105C4M (Ubiquinol oxidase) subunit I AS86_4706 ENOG4108V2W Carbonate dehydratase AS86_4709 ENOG410839T multidrug resistance protein AS86_4710 ENOG41080TC multidrug resistance protein AS86_4721 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AS86_4723 ENOG4105D2X ABC transporter substrate-binding protein AS86_4728 ENOG4107T7U Sulfatase AS86_4729 ENOG4107S9D Alpha beta hydrolase AS86_4730 ENOG4105CH6 catalase AS86_4731 ENOG4105BZU Histidine kinase AS86_4732 ENOG4105BZU Histidine kinase AS86_4748 ENOG4105EPU Molybdenum cofactor synthesis domain protein AS86_4750 ENOG4105BZF Glycosyl transferase (Group 1 AS86_4751 ENOG4105YVM Phosphoesterase, PA-phosphatase related AS86_4752 ENOG4108Z0R Transferase AS86_4753 ENOG4105E8V Alpha Beta Hydrolase Fold protein AS86_4758 ENOG4105N5T Radical SAM Protein AS86_476 ENOG4105CAR Terminase, large subunit AS86_4762 ENOG4105C19 ABC transporter AS86_4765 ENOG4105NCW Trka-c domain protein AS86_4766 ENOG4107S91 Sodium hydrogen exchanger AS86_4767 ENOG410605W Major Facilitator AS86_4775 ENOG4105DWV Homoserine O-trans-acetylase AS86_4777 ENOG41085GJ domain protein AS86_478 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AS86_4781 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AS86_4782 ENOG4105D06 uba thif-type nad fad binding protein AS86_4784 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS86_4785 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AS86_4786 ENOG4108ZAF Molybdopterin AS86_4789 ENOG4105CSC Glucose uptake protein AS86_4790 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AS86_4791 ENOG4108VJ1 Transcriptional regulator (CarD family AS86_4798 ENOG4105CBX hi0933 family AS86_4801 ENOG4105YW5 deoR family transcriptional regulator AS86_4802 ENOG4107QSE Dipeptidase AS86_4804 ENOG4108IUM Glycogen debranching enzyme AS86_4805 ENOG4108V15 phosphotransferase enzyme family AS86_4808 ENOG4105C8F Beta-lactamase domain protein AS86_4814 ENOG4108VDD TRNA binding domain protein AS86_4821 ENOG4108IPJ Membrane AS86_4825 ENOG4105C88 aminopeptidase AS86_4829 ENOG4105ETE Transcriptional regulator (LacI family AS86_4834 ENOG4105EP9 oxidoreductase AS86_4835 ENOG4107SNB ankyrin repeat protein YahD AS86_4836 ENOG4105BZU Histidine kinase AS86_4837 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS86_4840 ENOG4105DGU Histone deacetylase AS86_4841 ENOG4105W87 Cbs domain AS86_4842 ENOG4105F1V Acetoin utilization protein AS86_4844 ENOG4108UW5 maltose o-acetyltransferase AS86_4849 ENOG4105C28 cystathionine AS86_4851 ENOG4105U5Y Transcriptional regulator AS86_4853 ENOG4107RSM transcriptional regulator AS86_4858 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AS86_4860 ENOG4105EFZ amidohydrolase AS86_4863 ENOG4105KBJ sporulation protein ytfj AS86_4864 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AS86_4866 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AS86_4870 ENOG4108JYZ YitT family AS86_4879 ENOG4107YZX Universal stress protein AS86_4883 ENOG41082W1 Cupin 2, conserved barrel domain protein AS86_4884 ENOG4105Z7P Acetyltransferase (GNAT) family AS86_4890 ENOG4105DC7 peptidase M24 AS86_4896 ENOG4105SFS phosphoesterase RecJ domain protein AS86_4898 ENOG4105VV2 AS86_4899 ENOG4105C0B DNA polymerase III (alpha subunit) AS86_490 ENOG4105XSJ toxin secretion phage lysis holin AS86_4900 ENOG4105C6K Malic enzyme AS86_4901 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AS86_4906 ENOG4105FS0 cytoplasmic membrane protein AS86_4907 ENOG4108REF Sporulation integral membrane protein ytvi AS86_4909 ENOG4105BZN citrate synthase AS86_4910 ENOG4108HMX isocitrate dehydrogenase (NADP) AS86_4915 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS86_4916 ENOG4105BZU Histidine kinase AS86_4917 ENOG4105C2M dna polymerase I AS86_4918 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AS86_4920 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AS86_4921 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AS86_4922 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AS86_4927 ENOG4108TDW sporulation protein YtxC AS86_4928 ENOG4105C22 threonyL-tRNA synthetase AS86_4929 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AS86_4933 ENOG4105CN9 Peptidase m42 family protein AS86_4934 ENOG4108JGH Tetr family transcriptional regulator AS86_4935 ENOG4105CW7 secretion protein, HlyD family AS86_4936 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS86_4941 ENOG4108RWN rrna methyltransferase AS86_4943 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AS86_4944 ENOG4105C5S asparaginyl-tRNA synthetase AS86_4946 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AS86_4949 ENOG4105DCG PHP domain protein AS86_4952 ENOG4105FE9 pseudouridine synthase AS86_4954 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AS86_4956 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AS86_4959 ENOG4105E0A ABC, transporter AS86_4960 ENOG4105KFN sortase, SrtB family AS86_4962 ENOG4105DR4 Methyltransferase AS86_4965 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS86_4973 ENOG4105S6R Iron-hydroxamate transporter permease subunit AS86_4974 ENOG4105J76 Periplasmic binding protein AS86_4976 ENOG4105CEY Amp-dependent synthetase and ligase AS86_4977 ENOG4107Z3H Transcriptional regulator, TetR family AS86_4978 ENOG41060WC Enoyl-CoA hydratase AS86_4979 ENOG4105BZJ Electron transfer flavoprotein AS86_4980 ENOG4105C10 Electron transfer flavoprotein AS86_4981 ENOG4105K63 Thioredoxin AS86_4984 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AS86_4986 ENOG4105E33 succinate dehydrogenase AS86_4988 ENOG4108VXD carboxy-peptidase AS86_4989 ENOG4105E14 MotA TolQ exbB proton channel AS86_4990 ENOG4105ER2 Ompa motb domain protein AS86_4991 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AS86_4992 ENOG4108IUX (ABC) transporter AS86_4993 ENOG4105RHA ABC transporter, permease AS86_4994 ENOG4108Z40 Transcriptional regulator AS86_4995 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AS86_4997 ENOG4108JCI Transcriptional regulator AS86_4998 ENOG41067S9 phage shock protein C, PspC AS86_4999 ENOG4105DZC cytosine deaminase AS86_5001 ENOG4105PFC Transcriptional regulator AS86_5003 ENOG4105KBX Transcriptional regulator, TetR family AS86_5005 ENOG4108PCX Major Facilitator AS86_5007 ENOG4108XJQ germination protein AS86_5010 ENOG4105M59 Phosphodiesterase, mj0936 family AS86_5014 ENOG4105DQ6 Transposase AS86_5016 ENOG4108QCI YvbH-like oligomerisation region AS86_5022 ENOG4108IUQ atp-dependent protease AS86_5026 ENOG4105K56 Transcriptional regulator AS86_503 ENOG41067SE Tetr family transcriptional regulator AS86_5031 ENOG4105D52 delta-aminolevulinic acid dehydratase AS86_5033 ENOG41068KH stage VI sporulation protein D AS86_5035 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AS86_5036 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AS86_5040 ENOG4105DFF Rod shape-determining protein mreb AS86_5041 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AS86_5044 ENOG4107QMS site-determining protein AS86_5047 ENOG4105C03 ribonuclease AS86_5049 ENOG4105X36 (ribosomal) protein AS86_505 ENOG4105BZU Histidine kinase AS86_5054 ENOG4105EWM Histidine kinase AS86_5058 ENOG4105CQC Prephenate dehydratase AS86_5060 ENOG4108RPX mosc domain containing protein AS86_5063 ENOG4108IYU L-aspartate oxidase AS86_5064 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AS86_5070 ENOG4108HUF Transporter AS86_5073 ENOG41061AI Protein of unknown function (DUF2905) AS86_5076 ENOG4105VIE preprotein translocase, subunit YajC AS86_5078 ENOG4108QG2 Membrane AS86_5079 ENOG4105CKP Polysaccharide Biosynthesis Protein AS86_5081 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AS86_5082 ENOG41076HS cation diffusion facilitator family transporter AS86_5083 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AS86_5085 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AS86_5089 ENOG4105CUT histidyl-tRNA synthetase AS86_5091 ENOG4105CUZ uba thif-type nad fad binding protein AS86_5092 ENOG4108VCI transcription factor, rsfa family AS86_5093 ENOG4105D1H recombination factor protein RarA AS86_5095 ENOG4105C3J Cysteine desulfurase AS86_5096 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AS86_5098 ENOG4105C7H Helicase, RecD TraA family AS86_5099 ENOG41060CR AS86_51 ENOG4108IMY Transcriptional regulator AS86_5102 ENOG4105C02 permease AS86_5104 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS86_5108 ENOG4105HHA aminodeoxychorismate lyase AS86_5109 ENOG4108VQJ O-methyltransferase AS86_5110 ENOG4105XYU peptidase (U32 family) AS86_5111 ENOG4105CFP Peptidase U32 AS86_5113 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AS86_5115 ENOG4107XRG penicillin-binding protein AS86_5121 ENOG4105C28 cystathionine AS86_5122 ENOG4108EKI Dehydrogenase AS86_5124 ENOG4108V5C ABC transporter AS86_5125 ENOG4105S6R Iron-hydroxamate transporter permease subunit AS86_5133 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AS86_5135 ENOG4105MIR Phenylalanine 4-monooxygenase AS86_5136 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AS86_5143 ENOG4108MUZ hydrolase AS86_5144 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AS86_5145 ENOG4105G6Z alkaline phosphatase AS86_5148 ENOG4108TVJ Nitroreductase AS86_515 ENOG4105FAW cDP-glucose 4,6-dehydratase AS86_5152 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS86_5155 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AS86_5156 ENOG4105CQW ribosome biogenesis GTPase YqeH AS86_5158 ENOG410812S Rna-binding protein AS86_5160 ENOG4108WF2 Metal Dependent Phosphohydrolase AS86_5162 ENOG4105DXX methyltransferase AS86_5164 ENOG4105KQC Competence protein AS86_5165 ENOG4108UK2 deaminase AS86_5166 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AS86_5168 ENOG4105TQK DNA polymerase iii, delta' subunit AS86_5173 ENOG4105KVH Transcriptional regulator AS86_5174 ENOG4105CSA Coproporphyrinogen iii oxidase AS86_518 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AS86_5180 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AS86_5181 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AS86_5183 ENOG4105KTH gatB Yqey AS86_5184 ENOG41068P3 sporulation protein YqfC AS86_5186 ENOG4105C9A Phoh family AS86_5187 ENOG4105CTJ Metal Dependent Phosphohydrolase AS86_5189 ENOG4107YR5 Diacylglycerol kinase AS86_5190 ENOG4105KG3 cytidine deaminase AS86_5191 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AS86_5196 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AS86_5197 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS86_5200 ENOG4105EGD dinuclear metal center protein, YbgI family AS86_5205 ENOG41069ZM Protein of unknown function (DUF2624) AS86_5206 ENOG4108JYZ YitT family AS86_5207 ENOG4105FDK ABC transporter AS86_5209 ENOG4105N80 Ferric uptake regulator, Fur family AS86_5214 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS86_522 ENOG4105E1K spore germination protein AS86_5221 ENOG4108IMY Transcriptional regulator AS86_5238 ENOG4108C33 Resolvase AS86_524 ENOG4108M1A Chitin-binding protein AS86_525 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C AS86_5257 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AS86_5265 ENOG4107RF6 penicillin-binding protein AS86_5267 ENOG4105C8U phosphate abc transporter AS86_5268 ENOG4105C8U phosphate abc transporter AS86_5269 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AS86_5270 ENOG4108UTW Plays a role in the regulation of phosphate uptake AS86_5273 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AS86_5275 ENOG4105DKQ ROK family AS86_5277 ENOG4105C5X domain protein AS86_5281 ENOG4105C28 cystathionine AS86_5282 ENOG4105C28 cystathionine AS86_5284 ENOG4105C3R Methionine synthase AS86_5285 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AS86_5292 ENOG4107R6U sodium dicarboxylate symporter AS86_530 ENOG4105C5E polysaccharide biosynthesis protein AS86_5303 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AS86_5309 ENOG4105C0D helicase AS86_531 ENOG4105C1B dTDP-glucose 4-6-dehydratase AS86_5317 ENOG41080TC multidrug resistance protein AS86_532 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AS86_5322 ENOG4105WZW rhodanese family AS86_5323 ENOG41082GG biotin lipoate A B protein ligase AS86_533 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AS86_5330 ENOG4107YBY Hydrolase AS86_5331 ENOG4105CBJ Metal-dependent enzyme AS86_5334 ENOG4105DC7 peptidase M24 AS86_5339 ENOG4105CD2 stage iii sporulation protein aa AS86_5340 ENOG4105KR5 Stage iii sporulation protein AS86_5341 ENOG4108CQH stage III sporulation protein AC AS86_5342 ENOG4105KQ4 Stage iii sporulation protein ad AS86_5344 ENOG410644B Stage III sporulation protein af AS86_5348 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AS86_5349 ENOG4108ZSR alkaline shock protein AS86_5354 ENOG4105CTB Polyprenyl synthetase AS86_5356 ENOG4105DX0 Hemolysin A AS86_5357 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AS86_5358 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AS86_5359 ENOG4105S1Z Stage IV sporulation protein B AS86_536 ENOG4105D2T synthase AS86_5360 ENOG4107QQR Sporulation AS86_5368 ENOG4108C33 Resolvase AS86_5371 ENOG4105DQ6 Transposase AS86_5378 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS86_5380 ENOG4108JUB Transcriptional regulator AS86_5382 ENOG4107RDP Dehydrogenase AS86_5386 ENOG4105CPP Dehydrogenase, E1 component AS86_5387 ENOG4105C7S Dehydrogenase AS86_5389 ENOG4108QY0 Membrane AS86_5391 ENOG4105G7B Protein of unknown function (DUF2992) AS86_5393 ENOG4108HW3 (ABC) transporter AS86_5394 ENOG4105E5Q amino acid AbC transporter AS86_5395 ENOG4105CDA abc transporter atp-binding protein AS86_5396 ENOG4108QEG Membrane AS86_5397 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AS86_5399 ENOG4105D9U N-acetyltransferase AS86_5400 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AS86_5404 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AS86_541 ENOG4105CEP NADH dehydrogenase AS86_5410 ENOG4105EJQ L-serine dehydratase AS86_5411 ENOG4105II7 pyrroline-5-carboxylate reductase AS86_5412 ENOG41069FQ Metallo-beta-lactamase superfamily AS86_5413 ENOG4108IXY short-chain dehydrogenase reductase AS86_5416 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AS86_5419 ENOG4105DBV ornithine carbamoyltransferase AS86_5424 ENOG4105CGH 5'-nucleotidase AS86_5425 ENOG4105DFD Na H antiporter AS86_5427 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS86_5430 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS86_5431 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS86_5436 ENOG4108R6K riboflavin synthase, subunit alpha AS86_5437 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AS86_5441 ENOG4108YM7 Gcn5-related n-acetyltransferase AS86_5442 ENOG4105ETE Transcriptional regulator (LacI family AS86_5444 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AS86_5448 ENOG4105RHY Pfam:UPF0157 AS86_545 ENOG4105CQB FAD linked oxidase domain protein AS86_5450 ENOG4105CPC Aldo Keto reductase AS86_5454 ENOG4105MZ9 stage II sporulation protein m AS86_5455 ENOG4105I3K Ferric uptake regulator, Fur family AS86_5457 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS86_546 ENOG4105C09 Bile acid AS86_5462 ENOG4105D7N magnesium and cobalt transport protein CorA AS86_5469 ENOG4105DVE abc transporter atp-binding protein AS86_5470 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS86_5471 ENOG4105DZ1 carboxypeptidase AS86_5472 ENOG41082AN stage II sporulation protein AS86_5474 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS86_5475 ENOG4105C8J )-transporter AS86_5479 ENOG41090VF Stage v sporulation protein ac AS86_5480 ENOG4105CZ3 stage V sporulation protein ad AS86_5482 ENOG4105G6R Stage v sporulation protein ae AS86_5484 ENOG4105J7I hydrolase AS86_5485 ENOG4105PTM secreted protein AS86_5486 ENOG4107ZE5 PPIases accelerate the folding of proteins AS86_5493 ENOG4105CE4 GlcNAc 6-P deacetylase AS86_5495 ENOG4105FDP GntR family transcriptional regulator AS86_5497 ENOG4105CID antiterminator AS86_5500 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AS86_5504 ENOG4105BZU Histidine kinase AS86_5506 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AS86_5509 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AS86_551 ENOG4105CIS alcohol dehydrogenase AS86_5514 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AS86_5518 ENOG4105DTD Dehydrogenase AS86_5519 ENOG4105K7K Transcriptional regulator AS86_552 ENOG41082BM Transcriptional regulator, arsr family AS86_5526 ENOG4105CHU acetyl-coa acetyltransferase AS86_5535 ENOG4105CG3 alpha amylase, catalytic region AS86_5537 ENOG4107FKK extracellular solute-binding protein family 1 AS86_5539 ENOG4105EG2 ABC transporter, permease AS86_554 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AS86_5540 ENOG4105FKQ transcriptional regulator AS86_5541 ENOG4105CHM Aminotransferase AS86_5543 ENOG4108HGU Histidine kinase AS86_5554 ENOG4105UIN AS86_5556 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AS86_5559 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AS86_5560 ENOG4105EPM Diguanylate phosphodiesterase AS86_5563 ENOG4107IN1 Protein of unknown function (DUF1797) AS86_5565 ENOG4108XRC Protein of unknown function (DUF458) AS86_5572 ENOG4107ZYR domain protein AS86_5573 ENOG4105CN5 Metallo-Beta-Lactamase AS86_5575 ENOG4108X4Q Hydrolase AS86_5576 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AS86_5579 ENOG4105CPP Dehydrogenase, E1 component AS86_5589 ENOG4105CXN decarboxylase AS86_5593 ENOG4105ECY inositol monophosphatase AS86_5595 ENOG4105CI3 gtp-binding protein typa AS86_5596 ENOG4105QA2 AS86_560 ENOG4108A04 Beta-lactamase AS86_5600 ENOG4108IAB Phoh family AS86_5603 ENOG4105CNI cell division protein FtsW AS86_5604 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AS86_5614 ENOG4106UY4 Inherit from COG: Scp-like extracellular AS86_5617 ENOG4107TB6 phosphoglycerate mutase AS86_5621 ENOG4106H78 methyltransferase AS86_5622 ENOG4105H20 Sporulation integral membrane protein YlbJ AS86_5624 ENOG4105D78 K07001 NTE family protein AS86_5625 ENOG41063PX domain protein AS86_5627 ENOG4105KNH Nucleic acid-binding protein AS86_5635 ENOG4105CJN penicillin-binding protein AS86_5636 ENOG4105CJN penicillin-binding protein AS86_5637 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AS86_5640 ENOG4105CNI cell division protein FtsW AS86_5641 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AS86_5642 ENOG4105D4A Cell wall formation (By similarity) AS86_5644 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AS86_5645 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AS86_5647 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS86_5649 ENOG4105WR5 sporulation protein, YlmC YmxH family AS86_5650 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AS86_5651 ENOG4105DFA alanine racemase domain protein AS86_5653 ENOG41067XK integral membrane protein AS86_5654 ENOG4105DBK s4 domain protein AS86_5656 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AS86_5659 ENOG4105C34 Pseudouridine synthase AS86_566 ENOG4105DPN Oligoendopeptidase f AS86_567 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AS86_5675 ENOG4105DC7 peptidase M24 AS86_5676 ENOG4105F23 Fibronectin-binding protein AS86_5678 ENOG4105DSJ YicC domain protein AS86_568 ENOG4105E5K Alpha-amylase AS86_5682 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AS86_5683 ENOG4105C25 Primosomal protein n' AS86_5686 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AS86_5688 ENOG4108ZF3 Phosphatase AS86_5689 ENOG4105D9P serine threonine protein kinase AS86_5690 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AS86_5691 ENOG4105DJV ribulose-phosphate 3-epimerase AS86_5692 ENOG4105FJ0 thiamine AS86_5694 ENOG4108ZAA Alkaline-shock protein AS86_5695 ENOG4105DP4 dak2 domain fusion protein ylov AS86_5696 ENOG4105CB5 ATP-dependent DNA helicase recG AS86_5699 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AS86_570 ENOG4105C98 muts2 protein AS86_5700 ENOG4105CHR reductase AS86_5714 ENOG4108VJ1 Transcriptional regulator (CarD family AS86_5720 ENOG4105ETT transcriptional Regulator, LysR family AS86_5721 ENOG4107ZBN O-methyltransferase AS86_5722 ENOG4105F27 Major Facilitator AS86_5723 ENOG4105M4P Tetr family transcriptional regulator AS86_5727 ENOG4105F27 Major Facilitator AS86_5731 ENOG4105CZV ABC transporter AS86_5732 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AS86_5734 ENOG4105TRI Hydrolase AS86_574 ENOG4107V2S Transcriptional regulator AS86_5742 ENOG4105E98 transcriptional regulator DeoR family AS86_576 ENOG4107CUJ Protein of unknown function (DUF2690) AS86_5770 ENOG4105EKQ RNA-directed DNA polymerase AS86_5772 ENOG41065S2 pneumococcal vaccine antigen AS86_580 ENOG4105NX3 Membrane AS86_5801 ENOG4108EKI Dehydrogenase AS86_5805 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AS86_5808 ENOG4105CNW domain protein AS86_5809 ENOG4108IFG nitrite reductase, (NAD(P)H) AS86_5810 ENOG4105VCQ rubredoxin AS86_5811 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AS86_5813 ENOG4105D7V transposase AS86_5816 ENOG4108QTI )-transporter AS86_5817 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS86_5819 ENOG4107R7I amino acid AS86_582 ENOG4105WCN acetyltransferase AS86_5821 ENOG4105C7B Threonine dehydratase AS86_5822 ENOG4105CUB amino acid AS86_5823 ENOG4105F2M alpha beta hydrolase fold-3 domain protein AS86_5831 ENOG4105DQ6 Transposase AS86_5833 ENOG4105EA8 2-Nitropropane dioxygenase AS86_5836 ENOG4105BZU Histidine kinase AS86_5837 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_5839 ENOG4105C0H protease AS86_584 ENOG4107R3E Citrate transporter AS86_5841 ENOG4107WD8 ABC transporter, permease AS86_5845 ENOG4105NA0 Transcriptional regulator AS86_5847 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C AS86_5851 ENOG4108NNZ chitinase AS86_5852 ENOG4105D7V transposase AS86_5854 ENOG4108JUA Transcriptional regulator AS86_5855 ENOG4105CMT Dihydroxyacetone kinase AS86_5857 ENOG4105KRI phosphocarrier protein (HPr AS86_5858 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AS86_586 ENOG4108TN2 lmbE family AS86_5860 ENOG4105ETZ PTS System AS86_5861 ENOG4105F3R pts system mannose fructose sorbose family iid AS86_5863 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS86_5864 ENOG41061CK Antibiotic biosynthesis monooxygenase AS86_5868 ENOG4105NA0 Transcriptional regulator AS86_5870 ENOG4105PNM synthesis protein AS86_5871 ENOG4108VXD carboxy-peptidase AS86_5873 ENOG4108IMY Transcriptional regulator AS86_5874 ENOG4105BZC d-serine deaminase AS86_5877 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS86_5879 ENOG4105DQ6 Transposase AS86_5880 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AS86_5882 ENOG4105D7V transposase AS86_5883 ENOG4105KIR Thiol-disulfide oxidoreductase dcc AS86_5886 ENOG4105CUB amino acid AS86_5890 ENOG4105VZ8 Transcriptional regulator AS86_5891 ENOG4107D63 AS86_5893 ENOG4105CHH sulfate transporter AS86_5897 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AS86_5906 ENOG4105BZ4 penicillin-binding protein AS86_5909 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS86_5912 ENOG4105DM4 PTS System AS86_5913 ENOG4105DG6 mannose-6-phosphate isomerase AS86_5914 ENOG4105BZU Histidine kinase AS86_5915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_5918 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AS86_5921 ENOG4108IQI permease AS86_5922 ENOG4108J5H Homocysteine s-methyltransferase AS86_5924 ENOG4108IMY Transcriptional regulator AS86_5925 ENOG4105BZC d-serine deaminase AS86_5927 ENOG4105DQ6 Transposase AS86_593 ENOG4105CIS alcohol dehydrogenase AS86_5931 ENOG4107SET aldo keto reductase AS86_5942 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AS86_5944 ENOG4105CJW magnesium transporter AS86_5945 ENOG4105CNI cell division protein FtsW AS86_5946 ENOG4105FQP Beta-lactamase AS86_5947 ENOG4107SCK Monooxygenase AS86_5951 ENOG4106A3M Cytochrome p-450 AS86_5952 ENOG410625E AS86_5960 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AS86_5962 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AS86_5963 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AS86_5964 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AS86_5965 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AS86_5968 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AS86_5970 ENOG4105CHR reductase AS86_5971 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AS86_5973 ENOG4108KYE ABC-2 type transporter AS86_5974 ENOG4105CJ1 ABC, transporter AS86_5975 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein AS86_5990 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AS86_5993 ENOG4105BZ1 (ABC) transporter AS86_5996 ENOG4105CAQ asparagine synthetase AS86_5997 ENOG4105CHR reductase AS86_6 ENOG4105VB6 UPF0109 protein AS86_600 ENOG4105H3G oxidoreductase AS86_6000 ENOG41082UD thioesterase Superfamily protein AS86_6001 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AS86_6002 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AS86_6004 ENOG4105CEY Amp-dependent synthetase and ligase AS86_6005 ENOG4105CEY Amp-dependent synthetase and ligase AS86_6017 ENOG4105E4C Lytic transglycosylase catalytic AS86_6028 ENOG4107WD8 ABC transporter, permease AS86_6029 ENOG4105E98 transcriptional regulator DeoR family AS86_6030 ENOG4107XGZ Hydrolase AS86_6031 ENOG4108BUD transposase AS86_6032 ENOG4107RF6 penicillin-binding protein AS86_6034 ENOG4105EMN RNA polymerase sigma factor AS86_6075 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS86_6076 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS86_608 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AS86_6090 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AS86_61 ENOG4105CDU Replicative dna helicase AS86_6134 ENOG4108VXD carboxy-peptidase AS86_6166 ENOG4105IEH endo-beta-N-acetylglucosaminidase AS86_6182 ENOG4105MZU cell filamentation protein AS86_619 ENOG4108ZJ4 polysaccharide deacetylase AS86_6192 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS86_6193 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS86_6218 ENOG4105C2M dna polymerase I AS86_622 ENOG4107SCK Monooxygenase AS86_6223 ENOG410906U SprT-like AS86_623 ENOG4105KVH Transcriptional regulator AS86_624 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AS86_6240 ENOG4105EQI Metal Dependent Phosphohydrolase AS86_6255 ENOG4105D9P serine threonine protein kinase AS86_627 ENOG4105JAB phenazine biosynthesis protein, phzf family AS86_6339 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AS86_636 ENOG4105D9R oxidoreductase AS86_6361 ENOG4105C4R Atp-dependent dna helicase AS86_637 ENOG4108TZY GntR Family Transcriptional Regulator AS86_638 ENOG4105KVH Transcriptional regulator AS86_6418 ENOG4105C2M dna polymerase I AS86_644 ENOG4105C44 Serine transporter AS86_6478 ENOG4107XK4 dna polymerase iii subunits gamma and tau AS86_648 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AS86_649 ENOG4105CV1 Transketolase (EC 2.2.1.1) AS86_651 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AS86_652 ENOG4105CMG Carbohydrate kinase AS86_653 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AS86_6531 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AS86_654 ENOG4105XDF Protein of unknown function (DUF1272) AS86_6540 ENOG4105K4W Could be involved in septation (By similarity) AS86_6545 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) AS86_655 ENOG4105DDN Pentapeptide repeat-containing protein AS86_6559 ENOG4105C0B DNA polymerase III (alpha subunit) AS86_6561 ENOG4105C0B DNA polymerase III (alpha subunit) AS86_6564 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AS86_6566 ENOG4105EKQ RNA-directed DNA polymerase AS86_6568 ENOG4105GJD protein, conserved in bacteria AS86_6578 ENOG4107JM4 Tetratricopeptide repeat AS86_6590 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AS86_660 ENOG4105C37 (CBS) domain AS86_6612 ENOG4108UUM single-stranded DNA-binding protein AS86_6614 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AS86_6621 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AS86_6622 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AS86_6625 ENOG4105C4R Atp-dependent dna helicase AS86_6626 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AS86_6627 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AS86_6635 ENOG4105K6T rare lipoprotein A AS86_6636 ENOG4105C0D helicase AS86_6639 ENOG4105BZU Histidine kinase AS86_6640 ENOG4105GR3 Histidine kinase AS86_6645 ENOG4105ZMH deoxynucleoside kinase AS86_666 ENOG4105EV4 Multidrug resistance protein mdtH AS86_668 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AS86_6683 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AS86_6685 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AS86_6688 ENOG4106FN3 tellurium resistance protein AS86_6689 ENOG4106FN3 tellurium resistance protein AS86_6692 ENOG4107TS3 membrane protein, TerC AS86_6694 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AS86_6696 ENOG4105D9N nucleoside AS86_6701 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AS86_6702 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AS86_6703 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS86_6704 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS86_6712 ENOG4108IBT Inherit from COG: transposase AS86_676 ENOG4105C31 Tryptophanyl-tRNA synthetase AS86_678 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AS86_6797 ENOG4105CJA serine threonine protein kinase AS86_6800 ENOG4105BZ1 (ABC) transporter AS86_6801 ENOG4105K7K Transcriptional regulator AS86_681 ENOG4108UW5 maltose o-acetyltransferase AS86_6812 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS86_6813 ENOG4105CNA YD repeat protein AS86_6819 ENOG4105EA8 2-Nitropropane dioxygenase AS86_682 ENOG4106UW1 Major Facilitator superfamily AS86_683 ENOG4105DKQ ROK family AS86_6833 ENOG4105D13 transposase AS86_6837 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C AS86_684 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AS86_6879 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AS86_6895 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AS86_697 ENOG4108PSK reductase AS86_703 ENOG4108RCM Nitroreductase AS86_704 ENOG4105KVH Transcriptional regulator AS86_708 ENOG4108Z66 YbaK ebsC protein AS86_709 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AS86_711 ENOG4108K8S endonuclease I AS86_723 ENOG4105DYS nad(p)h dehydrogenase (quinone) AS86_725 ENOG4105CRW Short chain fatty acid transporter AS86_728 ENOG4105CZM Major Facilitator AS86_729 ENOG4107MII Sugar-specific transcriptional regulator TrmB AS86_732 ENOG4108ISG Major Facilitator AS86_734 ENOG4105PNM synthesis protein AS86_735 ENOG4108VXD carboxy-peptidase AS86_740 ENOG4107EV6 Inherit from COG: YD repeat protein AS86_763 ENOG4108IG5 Transcriptional regulator AS86_765 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS86_768 ENOG410874W AraC family transcriptional regulator AS86_769 ENOG41082W1 Cupin 2, conserved barrel domain protein AS86_772 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AS86_773 ENOG4108JQ1 Dehydrogenase AS86_779 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AS86_781 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AS86_782 ENOG4108U05 Transcriptional regulator AS86_785 ENOG4105BZU Histidine kinase AS86_789 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AS86_793 ENOG4105JQZ Methyltransferase AS86_797 ENOG4105K6H D-cysteine desulfhydrase AS86_799 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS86_800 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AS86_806 ENOG4105C19 ABC transporter AS86_808 ENOG4105DNP FAD linked oxidase domain protein AS86_815 ENOG4105BZU Histidine kinase AS86_816 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS86_824 ENOG4108YXU transcriptional regulator AsnC family AS86_825 ENOG4105CHR reductase AS86_826 ENOG4108IG5 Transcriptional regulator AS86_827 ENOG4107P5I polyketide synthase AS86_829 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AS86_831 ENOG4105VZ8 Transcriptional regulator AS86_839 ENOG4105EGI Transcriptional regulator AS86_841 ENOG41085FC arsR family transcriptional regulator AS86_842 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AS86_843 ENOG4105D6J arsenicaL-resistance protein AS86_847 ENOG4105DIK (ABC) transporter AS86_848 ENOG4105CC5 ABC transporter AS86_849 ENOG4105DSE periplasmic solute binding protein AS86_850 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AS86_852 ENOG4107VMI polysaccharide deacetylase AS86_853 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AS86_854 ENOG4108TWJ NADH dehydrogenase subunit 5 AS86_857 ENOG4105CVP deoxyribo-dipyrimidine photolyase AS86_858 ENOG4108606 TspO/MBR family AS86_861 ENOG4105F6J Alpha beta hydrolase fold AS86_866 ENOG41090MY MarR family Transcriptional regulator AS86_871 ENOG4105CHJ isochorismatase hydrolase AS86_874 ENOG4105CGH 5'-nucleotidase AS86_877 ENOG4106A3M Cytochrome p-450 AS86_885 ENOG4108Q8B Spore germination protein AS86_886 ENOG4108NHD germination protein AS86_887 ENOG4105II7 pyrroline-5-carboxylate reductase AS86_888 ENOG4105CUB amino acid AS86_889 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AS86_890 ENOG41075H3 AraC family transcriptional regulator AS86_895 ENOG4105BZU Histidine kinase AS86_897 ENOG4108B31 Spore germination protein AS86_899 ENOG4108IMY Transcriptional regulator AS86_900 ENOG4105HDK L-asparaginase AS86_901 ENOG4105HDK L-asparaginase AS86_902 ENOG4108IJ0 Aspartate ammonia-lyase AS86_904 ENOG4105E2A Dehydrogenase AS86_909 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AS86_917 ENOG4105DWD nucleoside recognition domain protein AS86_920 ENOG4105FDT acyl-CoA dehydrogenase AS86_922 ENOG4108ZHR arsR family transcriptional regulator AS86_923 ENOG4106N3A copper homeostasis protein cutc AS86_925 ENOG4107258 Transcriptional regulator AS86_926 ENOG4105P4J Allophanate hydrolase, subunit 1 AS86_932 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AS86_933 ENOG4107RF6 penicillin-binding protein AS86_938 ENOG4105BZU Histidine kinase AS86_941 ENOG4108VJ1 Transcriptional regulator (CarD family AS86_951 ENOG4108IQI permease AS86_953 ENOG410635A Membrane AS86_96 ENOG4108IBT Inherit from COG: transposase AS86_963 ENOG4108PCN EamA-like transporter family AS86_964 ENOG4105E09 nadh pyrophosphatase AS86_966 ENOG4108XET gCN5-related N-acetyltransferase AS86_97 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AS86_972 ENOG4105C19 ABC transporter AS86_973 ENOG4105CMR udp-glucose 4-epimerase AS86_974 ENOG4105WEC Molybdate metabolism regulator AS86_975 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AS86_978 ENOG4105FS7 Transcriptional regulator AS86_979 ENOG4108TVJ Nitroreductase AS86_983 ENOG4108IBT Inherit from COG: transposase AS86_984 ENOG4106BHF AS86_985 ENOG41090AA AS86_99 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AS86_991 ENOG4105C8Y Acetylornithine aminotransferase AS86_996 ENOG4105C7R Atpase associated with various cellular activities aaa_3