locus-tag class description A3L20_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A3L20_00015 ENOG410848D S4 domain protein YaaA A3L20_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A3L20_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) A3L20_00100 ENOG4105ZMH deoxynucleoside kinase A3L20_00110 ENOG4105GTG Isochorismatase A3L20_00115 ENOG4108Z6B deaminase A3L20_00125 ENOG4105C6E dna polymerase iii A3L20_00145 ENOG41067KS pro-sigma K processing A3L20_00180 ENOG4105CXN decarboxylase A3L20_00190 ENOG4105FA2 dna polymerase iii A3L20_00195 ENOG4105MA4 psp1 domain protein A3L20_00205 ENOG41060K3 Methyltransferase A3L20_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A3L20_00220 ENOG4105KRN Transcriptional regulator, abrb family A3L20_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) A3L20_00230 ENOG4105F8V Hydrolase, tatD family A3L20_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) A3L20_00245 ENOG4105XFA sporulation peptidase YabG A3L20_00250 ENOG4105W42 Veg protein A3L20_00265 ENOG4105DFT pur operon repressor A3L20_00270 ENOG4105KME endoribonuclease L-psp A3L20_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase A3L20_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A3L20_00300 ENOG4108JA2 transcriptioN-repair coupling factor A3L20_00305 ENOG4108M14 stage v sporulation protein t A3L20_00315 ENOG4108IY2 MazG family A3L20_00320 ENOG41082I2 s4 domain protein A3L20_00325 ENOG4105VYY sporulation protein yabp A3L20_00340 ENOG41060GV RNA binding s1 domain protein A3L20_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) A3L20_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase A3L20_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A3L20_00385 ENOG4105C6T cysteine synthase A3L20_00390 ENOG4105CRQ synthase (Component I) A3L20_00395 ENOG4105DDQ anthranilate synthase A3L20_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 A3L20_00405 ENOG4105EEI dihydropteroate synthase A3L20_00410 ENOG4105KRF dihydroneopterin aldolase A3L20_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase A3L20_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A3L20_00515 ENOG4108Z0C Uvrb UvrC protein A3L20_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) A3L20_00540 ENOG4105CTP PilT protein domain protein A3L20_00560 ENOG4105D7W serine acetyltransferase A3L20_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 A3L20_00580 ENOG4105M0M Tetracycline resistance protein A3L20_00585 ENOG4105QIV RNA polymerase A3L20_00595 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A3L20_00620 ENOG4107Y49 methyltransferase A3L20_00630 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A3L20_00635 ENOG4105XPM ribosomal protein A3L20_00740 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) A3L20_00765 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A3L20_00775 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A3L20_00785 ENOG41067V7 50S ribosomal protein L36 A3L20_00810 ENOG4108JJB ABC transporter A3L20_00815 ENOG4108JJB ABC transporter A3L20_00820 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) A3L20_00825 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A3L20_00850 ENOG4105D1F ATP-binding protein A3L20_00865 ENOG4108NMV polysaccharide deacetylase A3L20_00945 ENOG4105C8B TIGR00159 family A3L20_00950 ENOG4107U5W ybbr family A3L20_00965 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) A3L20_00985 ENOG4108PSK reductase A3L20_00990 ENOG4108UMI ABC transporter, permease A3L20_00995 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A3L20_01000 ENOG4105D01 (LipO)protein A3L20_01005 ENOG4105CB2 alcohol dehydrogenase A3L20_01015 ENOG4105IQ5 FAD linked oxidase domain protein A3L20_01030 ENOG4105C2C drug resistance transporter, Bcr CflA A3L20_01050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A3L20_01055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3L20_01060 ENOG4105C3U ABC transporter A3L20_01065 ENOG4108JQ7 (ABC) transporter A3L20_01085 ENOG4108J59 Extracellular solute-binding protein, family 5 A3L20_01090 ENOG4108J59 Extracellular solute-binding protein, family 5 A3L20_01110 ENOG4105E0C molybdate abc transporter A3L20_01115 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A3L20_01120 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family A3L20_01140 ENOG4105F6E Acyl-transferase A3L20_01155 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) A3L20_01165 ENOG4105IYK transposase A3L20_01170 ENOG4105DQ6 Transposase A3L20_01185 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) A3L20_01205 ENOG4105C5H ABC transporter A3L20_01215 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein A3L20_01225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3L20_01230 ENOG4105C3U ABC transporter A3L20_01235 ENOG4108JQ7 (ABC) transporter A3L20_01240 ENOG410667J hydrolase A3L20_01265 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase A3L20_01270 ENOG4105ERH Fumarylacetoacetate hydrolase A3L20_01280 ENOG4105CUB amino acid A3L20_01285 ENOG4108SC4 )-transporter A3L20_01290 ENOG4105CPF Cell wall formation (By similarity) A3L20_01295 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) A3L20_01320 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein A3L20_01325 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A3L20_01335 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) A3L20_01435 ENOG4105K8N protein family UPF0079, ATPase A3L20_01440 ENOG41072GX Peptidase M22 Glycoprotease A3L20_01445 ENOG410801F ribosomal-protein-alanine acetyltransferase A3L20_01450 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A3L20_01455 ENOG4105C5H ABC transporter A3L20_01470 ENOG4108TYN CAAX amino terminal protease family protein A3L20_01490 ENOG4105C7N Xanthine uracil vitamin C permease A3L20_01500 ENOG4105BZU Histidine kinase A3L20_01525 ENOG4107ZXU DSBA oxidoreductase A3L20_01545 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A3L20_01570 ENOG4105SX7 Transporter A3L20_01595 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) A3L20_01600 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit A3L20_01605 ENOG4105C83 adenylosuccinate lyase A3L20_01615 ENOG4105VR9 phosphoribosylformylglycinamidine synthase A3L20_01640 ENOG4108V3E phosphoribosylglycinamide formyltransferase A3L20_01650 ENOG4105C12 Phosphoribosylglycinamide synthetase A3L20_01675 ENOG4105C4R Atp-dependent dna helicase A3L20_01700 ENOG4108W2Y isochorismatase A3L20_01705 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A3L20_01710 ENOG4108UMI ABC transporter, permease A3L20_01715 ENOG4105D01 (LipO)protein A3L20_01730 ENOG410834F Transcriptional regulator A3L20_01735 ENOG4107I77 yiaA/B two helix domain A3L20_01755 ENOG4105CBD Diacylglycerol kinase A3L20_01765 ENOG4108JPW Aminotransferase A3L20_01775 ENOG4105C26 Dehydrogenase A3L20_01780 ENOG4105KPY Small multidrug resistance protein A3L20_01805 ENOG4105D9N nucleoside A3L20_01810 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A3L20_01815 ENOG4105VTR Integrase A3L20_01825 ENOG41067QW Transcriptional regulator A3L20_01855 ENOG4106CVF DNA replication protein A3L20_01865 ENOG4105KRN Transcriptional regulator, abrb family A3L20_01910 ENOG4105EKQ RNA-directed DNA polymerase A3L20_02080 ENOG4108W15 Protein of unknown function (DUF1456) A3L20_02095 ENOG4105DTQ mandelate racemase muconate lactonizing A3L20_02105 ENOG4105DFD Na H antiporter A3L20_02125 ENOG4105D3R alkyl hydroperoxide reductase A3L20_02130 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) A3L20_02135 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) A3L20_02140 ENOG4107W7X Aldolase A3L20_02145 ENOG4105EHG Permease protein A3L20_02150 ENOG4105DQ5 transport system permease protein A3L20_02155 ENOG4108V5C ABC transporter A3L20_02175 ENOG4106UIA A3L20_02180 ENOG4106UIA A3L20_02195 ENOG4105BZU Histidine kinase A3L20_02215 ENOG410756H nucleotidyltransferase A3L20_02220 ENOG4105DQ6 Transposase A3L20_02230 ENOG4105D2S major facilitator superfamily A3L20_02245 ENOG4105E5Q amino acid AbC transporter A3L20_02250 ENOG4105EAB amino acid AbC transporter A3L20_02260 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer A3L20_02280 ENOG4105DBV ornithine carbamoyltransferase A3L20_02290 ENOG4105C5B carbamate kinase A3L20_02295 ENOG4108W63 CRP FNR family transcriptional regulator A3L20_02305 ENOG4105DNP FAD linked oxidase domain protein A3L20_02315 ENOG4105CI1 PTS System A3L20_02330 ENOG4105C9U ATP-dependent DNA helicase RecQ A3L20_02345 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter A3L20_02370 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A3L20_02375 ENOG4105D2X ABC transporter substrate-binding protein A3L20_02410 ENOG41062JF Transcriptional regulator A3L20_02425 ENOG4105DEU major facilitator superfamily A3L20_02455 ENOG4108N0M stress protein A3L20_02460 ENOG4106FN3 tellurium resistance protein A3L20_02465 ENOG4106FN3 tellurium resistance protein A3L20_02470 ENOG4107TS3 membrane protein, TerC A3L20_02475 ENOG4108TTB tellurium resistance protein A3L20_02490 ENOG41068PA UPF0435 protein A3L20_02495 ENOG4105KJF protein tyrosine phosphatase A3L20_02505 ENOG4107U9T Pfam:Ribonuclease_BN A3L20_02510 ENOG4105C59 p-type ATPase A3L20_02515 ENOG4108IPJ Membrane A3L20_02535 ENOG4107ZTW SNARE associated Golgi A3L20_02550 ENOG410606W general stress protein A3L20_02555 ENOG4105UPD Calcium Proton A3L20_02595 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A3L20_02605 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A3L20_02615 ENOG4108JUB Transcriptional regulator A3L20_02625 ENOG4108IQI permease A3L20_02650 ENOG4105CSV Glutaminase A3L20_02660 ENOG4108A04 Beta-lactamase A3L20_02675 ENOG4107R51 Glycosyl transferase, family 2 A3L20_02680 ENOG4107QQG Dehydrogenase A3L20_02685 ENOG4105C3I Nad-dependent epimerase dehydratase A3L20_02690 ENOG4105CKK Glycosyl transferase, family 2 A3L20_02700 ENOG4105F1A Pyruvate formate-lyase A3L20_02720 ENOG4105CI2 imidazolone-5-propionate hydrolase A3L20_02725 ENOG4105ECP epimerase A3L20_02755 ENOG41067AE Membrane-bound metal-dependent hydrolase A3L20_02760 ENOG4105CEN a g-specific adenine glycosylase A3L20_02765 ENOG4106BXE A3L20_02785 ENOG4105BZ1 (ABC) transporter A3L20_02790 ENOG4107NBY Membrane A3L20_02795 ENOG4105CBC glutamate synthase A3L20_02805 ENOG4108IUW ABC transporter A3L20_02835 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A3L20_02840 ENOG4105G5W regulator Fur family A3L20_02960 ENOG4108JQC penicillin-binding protein 1A A3L20_02965 ENOG4108R9S DSBA oxidoreductase A3L20_02975 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) A3L20_02985 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) A3L20_02990 ENOG4105BZU Histidine kinase A3L20_02995 ENOG4105CYN Serine protein kinase A3L20_03010 ENOG4105C94 Transporter A3L20_03025 ENOG4105DZ6 Band 7 protein A3L20_03035 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism A3L20_03040 ENOG4108V9W transcriptional regulatory protein A3L20_03045 ENOG4105D4T Citrate transporter A3L20_03070 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator A3L20_03075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3L20_03080 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component A3L20_03085 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component A3L20_03090 ENOG4105BZ7 extracellular solute-binding protein family 1 A3L20_03095 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) A3L20_03100 ENOG4108STX response regulator A3L20_03105 ENOG4105US7 Histidine kinase A3L20_03130 ENOG4108MRH transcriptional regulatory protein A3L20_03140 ENOG4105C6K Malic enzyme A3L20_03150 ENOG4108UZ3 Transporter A3L20_03155 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A3L20_03165 ENOG4105BZU Histidine kinase A3L20_03190 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A3L20_03195 ENOG4108JB9 formate dehydrogenase A3L20_03215 ENOG4105CUB amino acid A3L20_03225 ENOG4105C59 p-type ATPase A3L20_03230 ENOG4105DAP Nicotinate phosphoribosyltransferase A3L20_03260 ENOG41073R8 VanW family A3L20_03265 ENOG4108KGH TRANSCRIPTIONal A3L20_03270 ENOG4105D9N nucleoside A3L20_03275 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase A3L20_03280 ENOG41085W3 Transposase A3L20_03285 ENOG4105C37 (CBS) domain A3L20_03290 ENOG4108IJ0 Aspartate ammonia-lyase A3L20_03295 ENOG4105DAA L-lactate A3L20_03310 ENOG4105DUX Transporter A3L20_03315 ENOG4108MES Periplasmic binding protein A3L20_03320 ENOG4105DQ5 transport system permease protein A3L20_03325 ENOG4108IHU transport system permease protein A3L20_03330 ENOG4105E0A ABC, transporter A3L20_03345 ENOG4105EXW epimerase dehydratase A3L20_03355 ENOG4107T89 von Willebrand factor, type A A3L20_03360 ENOG4105GMT ATPase associated with various cellular activities aaa_5 A3L20_03365 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A3L20_03380 ENOG4105D5Q Arginine ornithine antiporter A3L20_03385 ENOG4107414 GntR family transcriptional regulator A3L20_03390 ENOG4105C5Y PTS System A3L20_03395 ENOG4105CG3 alpha amylase, catalytic region A3L20_03410 ENOG4105E1K spore germination protein A3L20_03415 ENOG4105CRN Aminoglycoside phosphotransferase A3L20_03420 ENOG4105BZG amino acid carrier protein A3L20_03430 ENOG4105CDA abc transporter atp-binding protein A3L20_03435 ENOG4105CT1 (ABC) transporter A3L20_03440 ENOG4105EAD ABC transporter A3L20_03445 ENOG4105DRP amino acid AbC transporter A3L20_03450 ENOG4108IQI permease A3L20_03465 ENOG4105GFR rna polymerase sigma factor A3L20_03475 ENOG4105D29 Helix-turn-helix type 11 domain protein A3L20_03480 ENOG4105NAE bifunctional deaminase-reductase domain protein A3L20_03485 ENOG4105BZU Histidine kinase A3L20_03500 ENOG4105CHH sulfate transporter A3L20_03505 ENOG41068KF Universal stress protein A3L20_03515 ENOG4105CXY transporter A3L20_03520 ENOG41067TZ transcriptional regulator, MarR family A3L20_03525 ENOG4105C0R drug resistance transporter emrb qaca subfamily A3L20_03530 ENOG4105ETE Transcriptional regulator (LacI family A3L20_03535 ENOG4108RVA ribokinase A3L20_03545 ENOG4105C2J ABC transporter A3L20_03550 ENOG4105CNN ABC, transporter A3L20_03555 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A3L20_03560 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A3L20_03600 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) A3L20_03630 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A3L20_03635 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer A3L20_03640 ENOG41069ER domain protein A3L20_03645 ENOG4105VZ8 Transcriptional regulator A3L20_03650 ENOG4107D63 A3L20_03665 ENOG4105DUX Transporter A3L20_03685 ENOG4105C85 amino acid A3L20_03690 ENOG4105C7N Xanthine uracil vitamin C permease A3L20_03705 ENOG4105MA6 gCN5-related N-acetyltransferase A3L20_03730 ENOG4105BZ9 Cytochrome C oxidase, subunit I A3L20_03735 ENOG4105E2S oxidase) subunit II A3L20_03755 ENOG4106CAD Protein of unknown function (DUF3311) A3L20_03760 ENOG4105E1V na solute symporter A3L20_03775 ENOG4108NHD germination protein A3L20_03780 ENOG4105CE1 Ferrous iron transport protein b A3L20_03785 ENOG4105CE1 Ferrous iron transport protein b A3L20_03790 ENOG4105CE1 Ferrous iron transport protein b A3L20_03795 ENOG4105CVA phosphate A3L20_03800 ENOG4105C8U phosphate abc transporter A3L20_03805 ENOG4105E2Z phosphate ABC transporter (Permease A3L20_03935 ENOG41080XQ Signal transduction protein with cbs domains A3L20_03955 ENOG4105ETU transcriptional activator (TenA A3L20_03965 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A3L20_03975 ENOG4108VEU Thiamine monophosphate synthase A3L20_03980 ENOG41080HI glycine oxidase A3L20_03995 ENOG4105D06 uba thif-type nad fad binding protein A3L20_04000 ENOG4105DWF phosphomethylpyrimidine kinase A3L20_04050 ENOG4108INS Transcriptional regulator A3L20_04075 ENOG4105C19 ABC transporter A3L20_04085 ENOG4105C7N Xanthine uracil vitamin C permease A3L20_04095 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein A3L20_04115 ENOG4105C5Y PTS System A3L20_04130 ENOG4105K63 Thioredoxin A3L20_04150 ENOG4108B31 Spore germination protein A3L20_04170 ENOG4107Y03 Nitroreductase A3L20_04175 ENOG4105ED1 spovr family A3L20_04185 ENOG4108TCS Glutamyl endopeptidase A3L20_04195 ENOG4105XTG Pfam:DUF156 A3L20_04200 ENOG4107TPS domain protein A3L20_04205 ENOG4105VFE sira family A3L20_04210 ENOG4105VFE sira family A3L20_04220 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase A3L20_04225 ENOG41087NI Sulfite exporter TauE/SafE A3L20_04235 ENOG4108KGH TRANSCRIPTIONal A3L20_04260 ENOG4105EMD TRANSCRIPTIONal A3L20_04265 ENOG4105VCP PTS System A3L20_04270 ENOG4105VZJ PTS System A3L20_04295 ENOG41069ER domain protein A3L20_04300 ENOG4107RBB ABC transporter, permease A3L20_04305 ENOG4105C19 ABC transporter A3L20_04335 ENOG4105WEF catalase A3L20_04375 ENOG4107T5V SNARE associated Golgi A3L20_04405 ENOG4105CUB amino acid A3L20_04410 ENOG4107RWR Sodium hydrogen exchanger A3L20_04420 ENOG4106KNT transcriptional regulator A3L20_04460 ENOG4108YXU transcriptional regulator AsnC family A3L20_04470 ENOG4105KPY Small multidrug resistance protein A3L20_04505 ENOG4105BZ1 (ABC) transporter A3L20_04510 ENOG4105CJ1 ABC, transporter A3L20_04550 ENOG4105C19 ABC transporter A3L20_04555 ENOG4107RBB ABC transporter, permease A3L20_04560 ENOG4105C19 ABC transporter A3L20_04600 ENOG4107RKG DJ-1/PfpI family A3L20_04610 ENOG4105D5Q Arginine ornithine antiporter A3L20_04615 ENOG4105C26 Dehydrogenase A3L20_04620 ENOG4105BZ1 (ABC) transporter A3L20_04625 ENOG4105BZ1 (ABC) transporter A3L20_04635 ENOG4105DRP amino acid AbC transporter A3L20_04640 ENOG4105CDA abc transporter atp-binding protein A3L20_04655 ENOG410839P A3L20_04690 ENOG4107FQX Alpha-acetolactate decarboxylase A3L20_04715 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A3L20_04720 ENOG4105D4P Coproporphyrinogen iii oxidase A3L20_04725 ENOG4105CEY Amp-dependent synthetase and ligase A3L20_04740 ENOG4105CHH sulfate transporter A3L20_04765 ENOG4105CGU Enoyl-CoA hydratase A3L20_04785 ENOG4105DER m42 family A3L20_04805 ENOG4105CTU Proline racemase A3L20_04810 ENOG4105CIF Ornithine Cyclodeaminase A3L20_04825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3L20_04835 ENOG4108JQ7 (ABC) transporter A3L20_04890 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase A3L20_04910 ENOG4105D06 uba thif-type nad fad binding protein A3L20_04915 ENOG4107SFI Major Facilitator superfamily A3L20_04940 ENOG4105DQ6 Transposase A3L20_04960 ENOG4108IBT Inherit from COG: transposase A3L20_05070 ENOG4105CSH Transporter A3L20_05080 ENOG4108MRH transcriptional regulatory protein A3L20_05090 ENOG4105M6F mutator MutT protein A3L20_05095 ENOG4105C1J atp-dependent rna helicase A3L20_05105 ENOG4105CDU Replicative dna helicase A3L20_05135 ENOG4105C0R drug resistance transporter emrb qaca subfamily A3L20_05220 ENOG4107P5I polyketide synthase A3L20_05225 ENOG4108IG5 Transcriptional regulator A3L20_05240 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase A3L20_05255 ENOG4105CMT Dihydroxyacetone kinase A3L20_05275 ENOG410847I Transcriptional regulator, BadM Rrf2 family A3L20_05360 ENOG4105WN5 stage II sporulation protein A3L20_05370 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3L20_05380 ENOG4108MJI response regulator A3L20_05385 ENOG4105BZU Histidine kinase A3L20_05390 ENOG4105BZU Histidine kinase A3L20_05420 ENOG4105D7V transposase A3L20_05425 ENOG4105EKQ RNA-directed DNA polymerase A3L20_05435 ENOG4107QHE Choloylglycine hydrolase A3L20_05455 ENOG4107VRP DNA repair exonuclease A3L20_05460 ENOG4106D4I domain protein A3L20_05475 ENOG410829K Lysine exporter protein (Lyse ygga) A3L20_05490 ENOG4107JM4 Tetratricopeptide repeat A3L20_05500 ENOG4108MUZ hydrolase A3L20_05525 ENOG4105F0F Oxalate decarboxylase A3L20_05530 ENOG41067QW Transcriptional regulator A3L20_05535 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator A3L20_05550 ENOG4105C6V Glycerol-3-phosphate dehydrogenase A3L20_05560 ENOG4105EKQ RNA-directed DNA polymerase A3L20_05565 ENOG4105EKQ RNA-directed DNA polymerase A3L20_05570 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin A3L20_05585 ENOG4105EMN RNA polymerase sigma factor A3L20_05600 ENOG4105EEM helicase A3L20_05605 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A3L20_05630 ENOG4105K59 histidine triad (HIT) protein A3L20_05660 ENOG410905X membrane-flanked domain protein A3L20_05665 ENOG4105CKV Membrane A3L20_05705 ENOG410905X membrane-flanked domain protein A3L20_05710 ENOG4105CKV Membrane A3L20_05715 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation A3L20_05720 ENOG4105BZ4 penicillin-binding protein A3L20_05730 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A3L20_05735 ENOG4105C1Q protoporphyrinogen oxidase A3L20_05765 ENOG4105ECB domain protein A3L20_05795 ENOG4106AXD A3L20_05800 ENOG4108RQ5 Beta-lactamase domain-containing protein A3L20_05805 ENOG4105DF9 Lipoate-protein, ligase A3L20_05815 ENOG4105CEY Amp-dependent synthetase and ligase A3L20_05840 ENOG4105ENX hydrolase A3L20_05845 ENOG4107RN3 metallophosphoesterase A3L20_05850 ENOG4107TVP HD domain protein A3L20_05865 ENOG4108AEY RNA polymerase sigma factor A3L20_05870 ENOG41086D8 Transcriptional regulator A3L20_05885 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A3L20_05905 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 A3L20_05910 ENOG4105C8Q Methyl-accepting chemotaxis A3L20_05920 ENOG4105DQ6 Transposase A3L20_05930 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) A3L20_05940 ENOG4107QP3 malate synthase g A3L20_05960 ENOG4105VEQ Cold shock protein A3L20_05975 ENOG4105XVF Competence transcription factor A3L20_06040 ENOG4105ERH Fumarylacetoacetate hydrolase A3L20_06050 ENOG4105C8Y Acetylornithine aminotransferase A3L20_06065 ENOG4105CAQ asparagine synthetase A3L20_06080 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A3L20_06175 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) A3L20_06310 ENOG4105XSJ toxin secretion phage lysis holin A3L20_06340 ENOG4105CAQ asparagine synthetase A3L20_06345 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A3L20_06350 ENOG4105CH6 catalase A3L20_06355 ENOG4105BZU Histidine kinase A3L20_06380 ENOG4105QNR S1 RNA binding domain protein A3L20_06385 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A3L20_06390 ENOG4107AYK membrAne A3L20_06395 ENOG41073B9 A3L20_06405 ENOG4108KP7 hydrolase A3L20_06415 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A3L20_06440 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A3L20_06445 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A3L20_06465 ENOG4105C31 Tryptophanyl-tRNA synthetase A3L20_06480 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A3L20_06485 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3L20_06495 ENOG4108JQ7 (ABC) transporter A3L20_06500 ENOG4105UQX Mate efflux family protein A3L20_06520 ENOG4108ZCF integral membrane protein A3L20_06530 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A3L20_06540 ENOG4105DPN Oligoendopeptidase f A3L20_06550 ENOG4108Z18 K06886 hemoglobin A3L20_06555 ENOG4105MIX Adenylate cyclase A3L20_06570 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A3L20_06575 ENOG4105EMS pseudouridine synthase A3L20_06595 ENOG4105K64 Glycosyl transferase, family 2 A3L20_06615 ENOG4107TVC Glycosyl transferase, family 2 A3L20_06635 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) A3L20_06640 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase A3L20_06650 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase A3L20_06725 ENOG4105CK7 Sodium proline symporter A3L20_06735 ENOG4105CRQ synthase (Component I) A3L20_06740 ENOG4105DDQ anthranilate synthase A3L20_06835 ENOG4105C7S Dehydrogenase A3L20_06845 ENOG4105VZ8 Transcriptional regulator A3L20_06880 ENOG4108IUX (ABC) transporter A3L20_06915 ENOG4105DZ1 carboxypeptidase A3L20_06920 ENOG4105VFR signal peptidase A3L20_06955 ENOG4105C26 Dehydrogenase A3L20_06960 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3L20_06965 ENOG4105F38 ABC transporter, permease A3L20_06970 ENOG4105D38 putrescine abc transporter A3L20_06975 ENOG4107RUE extracellular solute-binding protein family 1 A3L20_06980 ENOG410841Q phosphoesterase PA-phosphatase related protein A3L20_06985 ENOG4105EYF MMPL domain protein A3L20_06995 ENOG4108YBP pseudouridine synthase A3L20_07010 ENOG4105K4I Scp-like extracellular A3L20_07015 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A3L20_07020 ENOG4105CQB FAD linked oxidase domain protein A3L20_07035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_07040 ENOG4105BZU Histidine kinase A3L20_07045 ENOG4105JXH GntR family transcriptional regulator A3L20_07065 ENOG4106A3R peptidase A3L20_07075 ENOG4108QTI )-transporter A3L20_07080 ENOG4107TS3 membrane protein, TerC A3L20_07085 ENOG4105CZN Potassium uptake protein A3L20_07090 ENOG410681C small acid-soluble spore protein A3L20_07095 ENOG4108Z7G MaoC domain protein dehydratase A3L20_07115 ENOG4105CHR reductase A3L20_07145 ENOG4105C4Y ABC transporter A3L20_07150 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3L20_07155 ENOG4107RCV ABC transporter, permease A3L20_07175 ENOG4105E98 transcriptional regulator DeoR family A3L20_07190 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) A3L20_07200 ENOG4105PXI polysaccharide deacetylase A3L20_07210 ENOG4105BZU Histidine kinase A3L20_07215 ENOG41090MY MarR family Transcriptional regulator A3L20_07225 ENOG4106DF1 A3L20_07235 ENOG4105BZU Histidine kinase A3L20_07245 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase A3L20_07250 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) A3L20_07290 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) A3L20_07295 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A3L20_07310 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family A3L20_07315 ENOG4105CZV ABC transporter A3L20_07325 ENOG4105CJ1 ABC, transporter A3L20_07365 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A A3L20_07370 ENOG4105EA8 2-Nitropropane dioxygenase A3L20_07375 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD A3L20_07385 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A3L20_07410 ENOG4105NQC Flavodoxin A3L20_07450 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A3L20_07480 ENOG4105CZN Potassium uptake protein A3L20_07485 ENOG41063Y9 A3L20_07490 ENOG4105KBJ sporulation protein ytfj A3L20_07510 ENOG4105CM2 brancheD-chain amino acid aminotransferase A3L20_07515 ENOG4105C7K acetolactate synthase A3L20_07520 ENOG4108ZP8 Acetolactate synthase small subunit A3L20_07525 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A3L20_07560 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) A3L20_07595 ENOG4107RVV histidinol phosphate phosphatase, hisj family A3L20_07615 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase A3L20_07620 ENOG4105E0M Sulfatase A3L20_07630 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) A3L20_07650 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) A3L20_07655 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) A3L20_07665 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A3L20_07670 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A3L20_07675 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein A3L20_07680 ENOG4105C8J )-transporter A3L20_07700 ENOG4105DFD Na H antiporter A3L20_07720 ENOG4105ENE Histidine kinase A3L20_07725 ENOG4105WH1 Two component transcriptional regulator luxr family A3L20_07745 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A3L20_07770 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) A3L20_07790 ENOG4105CJ3 phosphate transporter A3L20_07795 ENOG4107GRR phosphate transport regulator A3L20_07815 ENOG4105BZU Histidine kinase A3L20_07820 ENOG4105I3N Conserved Protein A3L20_07835 ENOG4105BZU Histidine kinase A3L20_07865 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A3L20_07870 ENOG4105DZ1 carboxypeptidase A3L20_07875 ENOG4108JIC nucleoside recognition domain protein A3L20_07885 ENOG4105FE9 pseudouridine synthase A3L20_07890 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A3L20_07895 ENOG4107TWT Cytochrome c biogenesis protein A3L20_07900 ENOG4105CRE cytochrome C A3L20_07905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_07910 ENOG4105BZU Histidine kinase A3L20_07915 ENOG4108WBT adenosyltransferase A3L20_07930 ENOG4108SAX Membrane A3L20_07945 ENOG4105C9U ATP-dependent DNA helicase RecQ A3L20_07950 ENOG4105I7S Abortive infection protein A3L20_07960 ENOG4107RGJ metallophosphoesterase A3L20_07965 ENOG4108XDN Transcriptional regulator A3L20_07970 ENOG4108S6Z Negative regulator of genetic competence A3L20_07995 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase A3L20_08000 ENOG4107RB3 L-asparaginase A3L20_08035 ENOG4105S2F A3L20_08040 ENOG41065D1 A3L20_08070 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) A3L20_08085 ENOG4105XXQ heptaprenyl diphosphate synthase component I A3L20_08095 ENOG4105EAH synthase A3L20_08100 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) A3L20_08105 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A3L20_08120 ENOG41068YB TPR repeat-containing protein A3L20_08135 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) A3L20_08140 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A3L20_08175 ENOG4108JYZ YitT family A3L20_08180 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase A3L20_08195 ENOG4105FJR Lmbe family A3L20_08200 ENOG4105CPK Glycosyl transferase (Group 1 A3L20_08235 ENOG4105DVT helicase A3L20_08240 ENOG4105YAC A3L20_08260 ENOG4105CSM endonuclease III A3L20_08270 ENOG4105BZ4 penicillin-binding protein A3L20_08330 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) A3L20_08340 ENOG4105DVT helicase A3L20_08345 ENOG4105CTD carboxy-peptidase A3L20_08350 ENOG4105DQ6 Transposase A3L20_08375 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A3L20_08385 ENOG4105C2W permease A3L20_08390 ENOG4105DHF Membrane A3L20_08395 ENOG410890F Dynamin family A3L20_08405 ENOG4108W0I acetyltransferase A3L20_08415 ENOG4105KHC sulfurtransferase A3L20_08440 ENOG4106032 Glutathionylspermidine synthase A3L20_08525 ENOG4108SZE gCN5-related N-acetyltransferase A3L20_08545 ENOG41081VK Ribonuclease A3L20_08610 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A3L20_08620 ENOG4107RWR Sodium hydrogen exchanger A3L20_08625 ENOG4105CN5 Metallo-Beta-Lactamase A3L20_08630 ENOG4108Z5V transcriptional regulator, merr family A3L20_08640 ENOG4105H67 Protein of unknown function (DUF421) A3L20_08645 ENOG41080C8 DUF218 domain A3L20_08675 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A3L20_08685 ENOG4107R0U MotA TolQ exbB proton channel A3L20_08690 ENOG4105ER2 Ompa motb domain protein A3L20_08695 ENOG4107YTP response regulator receiver protein A3L20_08700 ENOG4105CBS Chea signal transduction histidine kinase A3L20_08705 ENOG4105DD5 Flagellar motor switch protein A3L20_08720 ENOG4105BZU Histidine kinase A3L20_08740 ENOG4105E1Q flagellar hook-associated protein A3L20_08745 ENOG4105DTJ flagellar hook-associated protein A3L20_08765 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) A3L20_08770 ENOG4108ZC9 flagellar basal-body rod protein flgc A3L20_08775 ENOG41075Z6 flagellar hook-basal body complex protein fliE A3L20_08780 ENOG4107U2N Flagellar M-ring protein A3L20_08785 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A3L20_08815 ENOG4105BZE flagellar hook protein, FlgE A3L20_08830 ENOG4107R88 Chemotaxis protein (CheV) A3L20_08840 ENOG4105I03 Flagellin A3L20_08845 ENOG4105I03 Flagellin A3L20_08850 ENOG4105E4C Lytic transglycosylase catalytic A3L20_08860 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A3L20_08865 ENOG4105DD5 Flagellar motor switch protein A3L20_08875 ENOG4105CN7 Flagellar biosynthetic protein FliP A3L20_08880 ENOG4105VS8 Flagellar biosynthetic protein fliq A3L20_08890 ENOG4105D00 flagellar biosynthetic protein flhB A3L20_08895 ENOG4105D7B Flagellar biosynthesis protein flha A3L20_08900 ENOG4105FZW flagellar biosynthesis regulator FlhF A3L20_08905 ENOG4105KTQ flagellar basal-body rod protein A3L20_08910 ENOG4105CPU Monooxygenase A3L20_08915 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A3L20_08945 ENOG4105KAC Antibiotic biosynthesis monooxygenase A3L20_08950 ENOG4107QZ7 Cellulose synthase catalytic subunit A3L20_08975 ENOG4105DUM transcriptional regulator, lysR family A3L20_08980 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3L20_08990 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component A3L20_09030 ENOG4105CVJ phosphoglycerate mutase A3L20_09040 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) A3L20_09050 ENOG4105K56 Transcriptional regulator A3L20_09060 ENOG4105CAQ asparagine synthetase A3L20_09080 ENOG4105PGM cation diffusion facilitator family transporter A3L20_09095 ENOG4105CKI cobalamin synthesis protein A3L20_09100 ENOG4108PJD permease A3L20_09115 ENOG4105DFD Na H antiporter A3L20_09120 ENOG4105VUF Transcriptional regulator A3L20_09130 ENOG4105C9Q fumarate hydratase class II A3L20_09155 ENOG4107QJQ Mate efflux family protein A3L20_09160 ENOG4105EC3 peptidase S51, dipeptidase E A3L20_09180 ENOG4107QIV Cytochrome c biogenesis protein A3L20_09185 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A3L20_09210 ENOG4106BRA Membrane A3L20_09245 ENOG4105CJ1 ABC, transporter A3L20_09265 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A3L20_09275 ENOG4108IJ0 Aspartate ammonia-lyase A3L20_09280 ENOG4105C6K Malic enzyme A3L20_09335 ENOG4105FVX A3L20_09340 ENOG4105E09 nadh pyrophosphatase A3L20_09355 ENOG4105CSR polyphosphate kinase 2 A3L20_09360 ENOG4105U3E Transcriptional regulator A3L20_09370 ENOG4105DXI Major Facilitator superfamily A3L20_09380 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A3L20_09390 ENOG4105C6T cysteine synthase A3L20_09410 ENOG4105C8J )-transporter A3L20_09420 ENOG4105X5K response regulator receiver protein A3L20_09425 ENOG4105H67 Protein of unknown function (DUF421) A3L20_09445 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A3L20_09450 ENOG4105CHR reductase A3L20_09455 ENOG4105CM2 brancheD-chain amino acid aminotransferase A3L20_09460 ENOG4105C7K acetolactate synthase A3L20_09470 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A3L20_09480 ENOG4105C7B Threonine dehydratase A3L20_09505 ENOG4105C6X Major Facilitator A3L20_09510 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b A3L20_09525 ENOG4105DY9 regulatoR A3L20_09530 ENOG4105CYC Transferase A3L20_09545 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) A3L20_09555 ENOG41068WN A3L20_09560 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) A3L20_09575 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) A3L20_09585 ENOG4105C0X amino acid A3L20_09620 ENOG410849A acetyltransferase, (GNAT) family A3L20_09625 ENOG4105K8R UPF0145 protein A3L20_09640 ENOG4107RHR regulatoR A3L20_09650 ENOG4105D9N nucleoside A3L20_09655 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) A3L20_09675 ENOG4108IBT Inherit from COG: transposase A3L20_09705 ENOG4107RAQ aminopeptidase A3L20_09715 ENOG4107R16 Multicopper oxidase A3L20_09755 ENOG4108T5E Copper resistance protein A3L20_09760 ENOG4105KTB nuclear export factor GLE1 A3L20_09765 ENOG4107RT3 EamA-like transporter family A3L20_09770 ENOG4105GZI Transcriptional regulator A3L20_09775 ENOG4108Z40 Transcriptional regulator A3L20_09780 ENOG4107ZXU DSBA oxidoreductase A3L20_09785 ENOG4108TVJ Nitroreductase A3L20_09795 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A3L20_09800 ENOG4106F5Q Membrane A3L20_09805 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A3L20_09815 ENOG4105CKI cobalamin synthesis protein A3L20_09825 ENOG4105C0Z ABC transporter A3L20_09830 ENOG4108IV0 ABC, transporter A3L20_09835 ENOG4105C32 Amino acid ABC transporter (Permease) A3L20_09845 ENOG4105EGI Transcriptional regulator A3L20_09855 ENOG4105MDS 4-oxalocrotonate tautomerase A3L20_09875 ENOG4105C4M (Ubiquinol oxidase) subunit I A3L20_09880 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A3L20_09885 ENOG4108JJ9 ABC, transporter A3L20_09890 ENOG4108JJ8 (ABC) transporter A3L20_09900 ENOG4105K64 Glycosyl transferase, family 2 A3L20_09910 ENOG4108UT6 Transferase hexapeptide repeat containing protein A3L20_09965 ENOG4105BZ1 (ABC) transporter A3L20_10040 ENOG4108ZUE Phage regulatory protein rha A3L20_10065 ENOG4105CDU Replicative dna helicase A3L20_10225 ENOG4105BZ1 (ABC) transporter A3L20_10230 ENOG4105EFI regulatoR A3L20_10235 ENOG4105BZU Histidine kinase A3L20_10250 ENOG41075D4 Aminoglycoside 6-adenylyltransferase A3L20_10255 ENOG4108ZJ4 polysaccharide deacetylase A3L20_10275 ENOG41085W3 Transposase A3L20_10280 ENOG4105D6E homoserine dehydrogenase A3L20_10305 ENOG4108KGH TRANSCRIPTIONal A3L20_10310 ENOG4107VMI polysaccharide deacetylase A3L20_10320 ENOG4105KT7 mgtC SapB transporter A3L20_10330 ENOG4105DQ6 Transposase A3L20_10335 ENOG4105VRR gCN5-related N-acetyltransferase A3L20_10345 ENOG4105DUU IucA IucC family protein A3L20_10350 ENOG4105CEY Amp-dependent synthetase and ligase A3L20_10365 ENOG4108WBH protein TIM barrel A3L20_10370 ENOG4105YWU small acid-soluble spore protein A3L20_10380 ENOG4108ZUB Lysine exporter protein (Lyse ygga) A3L20_10385 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A3L20_10430 ENOG4105KRN Transcriptional regulator, abrb family A3L20_10440 ENOG4105YVS arsR family transcriptional regulator A3L20_10445 ENOG4105CPC Aldo Keto reductase A3L20_10480 ENOG4105C8Q Methyl-accepting chemotaxis A3L20_10495 ENOG4108K88 Membrane A3L20_10500 ENOG4108WPJ Ferritin-like domain A3L20_10515 ENOG4105DEN Luciferase family A3L20_10530 ENOG4105VMI -acetyltransferase A3L20_10535 ENOG4107QM2 Aldo Keto reductase A3L20_10540 ENOG4105CKI cobalamin synthesis protein A3L20_10550 ENOG4105DSE periplasmic solute binding protein A3L20_10565 ENOG4105K4T epimerase A3L20_10575 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A3L20_10600 ENOG4105CVJ phosphoglycerate mutase A3L20_10620 ENOG4107T5V SNARE associated Golgi A3L20_10635 ENOG4108PJD permease A3L20_10645 ENOG4108S4H thioesterase Superfamily protein A3L20_10650 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A3L20_10670 ENOG4105SXS Protein of unknown function (DUF456) A3L20_10675 ENOG4105C37 (CBS) domain A3L20_10700 ENOG4105DQ6 Transposase A3L20_10705 ENOG4105IYK transposase A3L20_10715 ENOG4108Z7R Chaperone CsaA A3L20_10730 ENOG4108ZRV stage ii sporulation protein p A3L20_10740 ENOG4108VXD carboxy-peptidase A3L20_10770 ENOG4108ZRV stage ii sporulation protein p A3L20_10810 ENOG4106050 phage regulatory protein, rha family A3L20_10920 ENOG4105CAR Terminase, large subunit A3L20_10925 ENOG41085W3 Transposase A3L20_10935 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A3L20_10985 ENOG4105EKQ RNA-directed DNA polymerase A3L20_11010 ENOG4105XSJ toxin secretion phage lysis holin A3L20_11015 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase A3L20_11060 ENOG41082F9 transcriptional regulator A3L20_11065 ENOG4105D94 Major Facilitator Superfamily A3L20_11075 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A3L20_11080 ENOG4107RBS Methyltransferase A3L20_11095 ENOG41087PP glycosyltransferase MGT family A3L20_11100 ENOG4108JYZ YitT family A3L20_11105 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A3L20_11135 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) A3L20_11165 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) A3L20_11240 ENOG4105KBJ sporulation protein ytfj A3L20_11265 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A3L20_11285 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) A3L20_11290 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily A3L20_11300 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A3L20_11305 ENOG4105EMN RNA polymerase sigma factor A3L20_11315 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) A3L20_11325 ENOG4105CNW domain protein A3L20_11335 ENOG4108V06 Glutathione peroxidase A3L20_11350 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A3L20_11360 ENOG4108IUE nitrate reductase beta subunit A3L20_11365 ENOG4105R3A Nitrate reductase A3L20_11375 ENOG4107V6Q Cyclic nucleotide-binding domain A3L20_11380 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A3L20_11385 ENOG4105D06 uba thif-type nad fad binding protein A3L20_11390 ENOG4105CVM Molybdenum cofactor synthesis domain protein A3L20_11395 ENOG4108ZAF Molybdopterin A3L20_11420 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein A3L20_11425 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A3L20_11430 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A3L20_11435 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit A3L20_11440 ENOG4108IFG nitrite reductase, (NAD(P)H) A3L20_11445 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) A3L20_11480 ENOG4105MCT stage V sporulation protein S A3L20_11515 ENOG4105C5H ABC transporter A3L20_11535 ENOG4108UUM single-stranded DNA-binding protein A3L20_11565 ENOG4107YX5 Pfam:DUF548 A3L20_11570 ENOG4105C75 arginyL-tRNA synthetase A3L20_11585 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A3L20_11605 ENOG4105C8J )-transporter A3L20_11610 ENOG4108EF6 Proline imino-peptidase A3L20_11625 ENOG4107XGZ Hydrolase A3L20_11630 ENOG4105CY2 Citrate transporter A3L20_11650 ENOG4105KD7 acetyltransferase A3L20_11665 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase A3L20_11690 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 A3L20_11705 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) A3L20_11720 ENOG4107RVG penicillin-binding protein A3L20_11730 ENOG4105E9Q Acyl-transferase A3L20_11735 ENOG4108UT2 hemolysin iii A3L20_11745 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A3L20_11755 ENOG4108RCR degv family A3L20_11765 ENOG4108KF3 Electron transport protein SCO1 SenC A3L20_11770 ENOG4107Y70 Heat shock protein A3L20_11775 ENOG4105CAQ asparagine synthetase A3L20_11790 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A3L20_11795 ENOG4108MES Periplasmic binding protein A3L20_11800 ENOG4105F0I Aminotransferase A3L20_11830 ENOG4105D8X mechanosensitive ion channel A3L20_11835 ENOG4105BZU Histidine kinase A3L20_11840 ENOG4105WH1 Two component transcriptional regulator luxr family A3L20_11845 ENOG4106KNT transcriptional regulator A3L20_11850 ENOG4107ZY0 Phenazine biosynthesis-like protein A3L20_11870 ENOG4105CMG Carbohydrate kinase A3L20_11875 ENOG4105C6Z Gluconate A3L20_11885 ENOG4108YV3 Protein of unknown function (DUF2711) A3L20_11915 ENOG4108IJ8 ABC transporter A3L20_11920 ENOG4105E90 ABC transporter A3L20_11955 ENOG4105C37 (CBS) domain A3L20_11980 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A3L20_11995 ENOG4107S4Y M20 DapE family protein YgeY A3L20_12000 ENOG4108TSC N-acetyltransferase A3L20_12005 ENOG4108JUB Transcriptional regulator A3L20_12010 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein A3L20_12050 ENOG410841Q phosphoesterase PA-phosphatase related protein A3L20_12060 ENOG4105SZ6 Thioredoxin A3L20_12065 ENOG4105KNA -acetyltransferase A3L20_12120 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A3L20_12175 ENOG4105BZ4 penicillin-binding protein A3L20_12185 ENOG4105CZM Major Facilitator A3L20_12190 ENOG4105W8X HesB YadR YfhF-family protein A3L20_12200 ENOG4105DXD 2-methylcitrate dehydratase A3L20_12205 ENOG4105CR4 methylisocitrate lyase A3L20_12210 ENOG4105C1G acyl-Coa dehydrogenase A3L20_12215 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A3L20_12225 ENOG4105N14 lysine exporter protein LysE YggA A3L20_12230 ENOG4105E39 Enoyl-CoA hydratase A3L20_12245 ENOG4107RFY SbcCD D subunit A3L20_12250 ENOG4105EYH Exonuclease A3L20_12270 ENOG4105FCD Major Facilitator A3L20_12275 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase A3L20_12280 ENOG4105E4F Isochorismate synthase A3L20_12285 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase A3L20_12290 ENOG4105WQI isochorismatase A3L20_12295 ENOG4105CEY Amp-dependent synthetase and ligase A3L20_12300 ENOG4105WQT MbtH domain protein A3L20_12305 ENOG4105C0R drug resistance transporter emrb qaca subfamily A3L20_12320 ENOG4105K70 DNA-binding protein A3L20_12340 ENOG4105BZG amino acid carrier protein A3L20_12360 ENOG4105FE9 pseudouridine synthase A3L20_12365 ENOG4105C22 threonyL-tRNA synthetase A3L20_12370 ENOG4105C19 ABC transporter A3L20_12400 ENOG41081I9 integral membrane protein A3L20_12410 ENOG4108Y4K DNA-binding transcriptional activator A3L20_12425 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A3L20_12435 ENOG4105EYF MMPL domain protein A3L20_12460 ENOG4105WCN acetyltransferase A3L20_12485 ENOG4105C1Q protoporphyrinogen oxidase A3L20_12495 ENOG41068WN A3L20_12525 ENOG4107V2S Transcriptional regulator A3L20_12530 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A3L20_12540 ENOG4105DND Transcriptional regulator A3L20_12545 ENOG4108RPX mosc domain containing protein A3L20_12560 ENOG4105BZ1 (ABC) transporter A3L20_12565 ENOG4105BZ1 (ABC) transporter A3L20_12590 ENOG4108JCI Transcriptional regulator A3L20_12620 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) A3L20_12625 ENOG4108KPJ rna polymerase sigma factor A3L20_12655 ENOG4105F32 YngK protein A3L20_12680 ENOG4105RD7 BadF BadG BcrA BcrD A3L20_12685 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A3L20_12690 ENOG4107STF Involved in phosphonate degradation (By similarity) A3L20_12695 ENOG4105C7B Threonine dehydratase A3L20_12700 ENOG4108INS Transcriptional regulator A3L20_12715 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A3L20_12725 ENOG4105C1J atp-dependent rna helicase A3L20_12735 ENOG4108RZE Tetr family transcriptional regulator A3L20_12770 ENOG4105EKQ RNA-directed DNA polymerase A3L20_12840 ENOG4105EKQ RNA-directed DNA polymerase A3L20_12850 ENOG41088CC tellurite resistance protein tehB A3L20_12860 ENOG4108I0C methyltransferase A3L20_12865 ENOG4107RA9 decarboxylase A3L20_12900 ENOG4105CIN aminoacyl-histidine dipeptidase A3L20_12925 ENOG4105KRN Transcriptional regulator, abrb family A3L20_12935 ENOG4105EJ9 Membrane A3L20_12980 ENOG4105W8Z 4'-phosphopantetheinyl transferase A3L20_12990 ENOG4105CHR reductase A3L20_13040 ENOG4105EKQ RNA-directed DNA polymerase A3L20_13055 ENOG4108W0I acetyltransferase A3L20_13060 ENOG4107QQG Dehydrogenase A3L20_13065 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A3L20_13070 ENOG4108IAJ Nad-dependent epimerase dehydratase A3L20_13075 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A3L20_13090 ENOG4105FJR Lmbe family A3L20_13100 ENOG4105IIU Aminopeptidase A3L20_13105 ENOG4108SC4 )-transporter A3L20_13155 ENOG4108IMY Transcriptional regulator A3L20_13170 ENOG4107VMI polysaccharide deacetylase A3L20_13175 ENOG4108RZE Tetr family transcriptional regulator A3L20_13180 ENOG4105CAQ asparagine synthetase A3L20_13185 ENOG4108XG2 Histidine kinase A3L20_13195 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin A3L20_13245 ENOG4107RVG penicillin-binding protein A3L20_13260 ENOG4107RF6 penicillin-binding protein A3L20_13265 ENOG4107RF6 penicillin-binding protein A3L20_13275 ENOG4105DIN metallophosphoesterase A3L20_13285 ENOG4105CJ1 ABC, transporter A3L20_13295 ENOG4107Z3H Transcriptional regulator, TetR family A3L20_13310 ENOG4105C1G acyl-Coa dehydrogenase A3L20_13315 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A3L20_13320 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit A3L20_13325 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase A3L20_13330 ENOG4105E39 Enoyl-CoA hydratase A3L20_13335 ENOG4107QX3 carboxylase A3L20_13340 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A3L20_13350 ENOG41085W3 Transposase A3L20_13365 ENOG4105DBI uridine monophosphokinase A3L20_13375 ENOG4105DZ1 carboxypeptidase A3L20_13405 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) A3L20_13425 ENOG41075H3 AraC family transcriptional regulator A3L20_13455 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A3L20_13465 ENOG4105CHR reductase A3L20_13470 ENOG4105KVH Transcriptional regulator A3L20_13505 ENOG4105DQ6 Transposase A3L20_13535 ENOG4105DQ6 Transposase A3L20_13550 ENOG4105CPQ Dehydrogenase A3L20_13560 ENOG410900G Protein of unknown function (DUF421) A3L20_13570 ENOG4108V4B ThiJ pfpI A3L20_13580 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein A3L20_13585 ENOG4105DK7 lysyl-tRNA synthetase A3L20_13610 ENOG4105EKQ RNA-directed DNA polymerase A3L20_13620 ENOG4106NZI LysR family Transcriptional regulator A3L20_13625 ENOG4105CPC Aldo Keto reductase A3L20_13670 ENOG4105D6E homoserine dehydrogenase A3L20_13680 ENOG4105CPF Cell wall formation (By similarity) A3L20_13685 ENOG4105ETU transcriptional activator (TenA A3L20_13710 ENOG4105VTR Integrase A3L20_13720 ENOG4108IMY Transcriptional regulator A3L20_13740 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A3L20_13805 ENOG41085W3 Transposase A3L20_13815 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A3L20_13820 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A3L20_13900 ENOG410667J hydrolase A3L20_13905 ENOG4105BZU Histidine kinase A3L20_13910 ENOG4107RF6 penicillin-binding protein A3L20_13935 ENOG4108JJB ABC transporter A3L20_13945 ENOG4108HGU Histidine kinase A3L20_14025 ENOG4105CB2 alcohol dehydrogenase A3L20_14030 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase A3L20_14035 ENOG4105CJN penicillin-binding protein A3L20_14095 ENOG4107VXM glycerophosphoryl diester phosphodiesterase A3L20_14120 ENOG4107Y9U Membrane A3L20_14140 ENOG4105EGD dinuclear metal center protein, YbgI family A3L20_14145 ENOG4105M6F mutator MutT protein A3L20_14165 ENOG4105FCD Major Facilitator A3L20_14175 ENOG4105DQ6 Transposase A3L20_14185 ENOG4105E09 nadh pyrophosphatase A3L20_14190 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A3L20_14195 ENOG4108Z4K mutator MutT protein A3L20_14205 ENOG4105DQ6 Transposase A3L20_14230 ENOG4108XI2 Domain of unknown function (DUF1963) A3L20_14250 ENOG4108NRW Phospholipase, patatin family A3L20_14255 ENOG4105KWG Pfam:DUF1696 A3L20_14280 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A3L20_14290 ENOG4105PKS Excinuclease abc c subunit domain protein A3L20_14325 ENOG41087PP glycosyltransferase MGT family A3L20_14345 ENOG4107VFR oxidoreductase A3L20_14380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_14385 ENOG4105BZU Histidine kinase A3L20_14405 ENOG4107WD8 ABC transporter, permease A3L20_14420 ENOG4105DY8 decarboxylase A3L20_14435 ENOG4108IUM Glycogen debranching enzyme A3L20_14445 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic A3L20_14460 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) A3L20_14465 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A3L20_14470 ENOG4108Q5Y Membrane A3L20_14475 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A3L20_14525 ENOG4105MSI germination protein ypeb A3L20_14555 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) A3L20_14560 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) A3L20_14565 ENOG4107Z3H Transcriptional regulator, TetR family A3L20_14580 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family A3L20_14595 ENOG4105E98 transcriptional regulator DeoR family A3L20_14610 ENOG41062ES Transcriptional regulator A3L20_14765 ENOG4105C2M dna polymerase I A3L20_14925 ENOG4105IG6 Phage terminase, large subunit A3L20_14950 ENOG4107QKR Dehydrogenase A3L20_14960 ENOG4107RUY (E1 component), alpha subunit A3L20_14970 ENOG4105E1F short-chain dehydrogenase reductase A3L20_15000 ENOG4107SQ8 Glycine betaine A3L20_15005 ENOG4108IJ7 Glycine betaine A3L20_15015 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A3L20_15030 ENOG4105E66 phosphoriboisomerase A A3L20_15035 ENOG41082BV acetyltransferase A3L20_15055 ENOG4108M1A Chitin-binding protein A3L20_15070 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) A3L20_15085 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) A3L20_15090 ENOG4105MSB protein, conserved in bacteria A3L20_15115 ENOG4108Z7F N-acetyltransferase A3L20_15140 ENOG4105KEG ribosomal-protein-alanine acetyltransferase A3L20_15145 ENOG4105EEM helicase A3L20_15155 ENOG41066HZ AIG2-like family A3L20_15160 ENOG4105C9U ATP-dependent DNA helicase RecQ A3L20_15185 ENOG4105DQ6 Transposase A3L20_15225 ENOG4108M1A Chitin-binding protein A3L20_15245 ENOG4105BZG amino acid carrier protein A3L20_15250 ENOG4105C26 Dehydrogenase A3L20_15255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A3L20_15265 ENOG4105CTU Proline racemase A3L20_15270 ENOG41080HI glycine oxidase A3L20_15280 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein A3L20_15310 ENOG4107T5V SNARE associated Golgi A3L20_15320 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD A3L20_15335 ENOG4105DTQ mandelate racemase muconate lactonizing A3L20_15350 ENOG4107SET aldo keto reductase A3L20_15390 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A3L20_15395 ENOG4105BZU Histidine kinase A3L20_15400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_15425 ENOG4105DPN Oligoendopeptidase f A3L20_15430 ENOG4105EPR degv family A3L20_15490 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) A3L20_15495 ENOG4106K7D Major facilitator family transporter A3L20_15515 ENOG4107BMA Transglycosylase associated protein A3L20_15570 ENOG4105CHM Aminotransferase A3L20_15585 ENOG4108ZMI UPF0477 protein A3L20_15600 ENOG4105DVE abc transporter atp-binding protein A3L20_15645 ENOG4105C02 permease A3L20_15660 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component A3L20_15665 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein A3L20_15670 ENOG4105D7T ABC transporter A3L20_15680 ENOG4105IYK transposase A3L20_15685 ENOG4105DQ6 Transposase A3L20_15705 ENOG4108AQF aminoglycoside N(3)-acetyltransferase A3L20_15740 ENOG4107VC0 DNA alkylation repair enzyme A3L20_15745 ENOG4105C6T cysteine synthase A3L20_15750 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase A3L20_15765 ENOG4107VMI polysaccharide deacetylase A3L20_15785 ENOG4108ZCF integral membrane protein A3L20_15790 ENOG4105E0M Sulfatase A3L20_15795 ENOG4105C5H ABC transporter A3L20_15800 ENOG4105EYF MMPL domain protein A3L20_15805 ENOG41082JN Transcriptional regulator A3L20_15830 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A3L20_15835 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A3L20_15865 ENOG41069ER domain protein A3L20_15895 ENOG4105D4B ABC, transporter A3L20_15905 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane A3L20_15910 ENOG4105C2J ABC transporter A3L20_15915 ENOG4105DKT Transcriptional regulator A3L20_15920 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) A3L20_15930 ENOG41061GT Aldolase A3L20_15955 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) A3L20_15990 ENOG4105II7 pyrroline-5-carboxylate reductase A3L20_16000 ENOG4107258 Transcriptional regulator A3L20_16020 ENOG4105ECK Fatty Acid Desaturase A3L20_16030 ENOG4107RBI VanW family A3L20_16035 ENOG4105G6Z alkaline phosphatase A3L20_16045 ENOG4105VMP Transcriptional regulator A3L20_16065 ENOG4105KNA -acetyltransferase A3L20_16090 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A3L20_16115 ENOG4105C8Y Acetylornithine aminotransferase A3L20_16145 ENOG41090AA A3L20_16150 ENOG4106BHF A3L20_16160 ENOG4108IBT Inherit from COG: transposase A3L20_16180 ENOG4105DQ6 Transposase A3L20_16190 ENOG4108TVJ Nitroreductase A3L20_16195 ENOG4105FS7 Transcriptional regulator A3L20_16210 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) A3L20_16215 ENOG4105WEC Molybdate metabolism regulator A3L20_16240 ENOG4108XET gCN5-related N-acetyltransferase A3L20_16250 ENOG4105E09 nadh pyrophosphatase A3L20_16255 ENOG4108PCN EamA-like transporter family A3L20_16300 ENOG410635A Membrane A3L20_16310 ENOG4108IQI permease A3L20_16355 ENOG4108VJ1 Transcriptional regulator (CarD family A3L20_16385 ENOG4107RF6 penicillin-binding protein A3L20_16390 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) A3L20_16420 ENOG4105P4J Allophanate hydrolase, subunit 1 A3L20_16425 ENOG4107258 Transcriptional regulator A3L20_16435 ENOG4106N3A copper homeostasis protein cutc A3L20_16440 ENOG4108ZHR arsR family transcriptional regulator A3L20_16450 ENOG4105FDT acyl-CoA dehydrogenase A3L20_16465 ENOG4105DWD nucleoside recognition domain protein A3L20_16495 ENOG4105DQ6 Transposase A3L20_16500 ENOG4105IYK transposase A3L20_16515 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) A3L20_16525 ENOG4105DQ6 Transposase A3L20_16585 ENOG4105E2A Dehydrogenase A3L20_16595 ENOG4108IJ0 Aspartate ammonia-lyase A3L20_16600 ENOG4105HDK L-asparaginase A3L20_16605 ENOG4108IMY Transcriptional regulator A3L20_16615 ENOG4108B31 Spore germination protein A3L20_16625 ENOG4105BZU Histidine kinase A3L20_16650 ENOG41075H3 AraC family transcriptional regulator A3L20_16655 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A3L20_16660 ENOG4105CUB amino acid A3L20_16665 ENOG4105II7 pyrroline-5-carboxylate reductase A3L20_16670 ENOG4108NHD germination protein A3L20_16675 ENOG4108Q8B Spore germination protein A3L20_16710 ENOG4106A3M Cytochrome p-450 A3L20_16725 ENOG4105CGH 5'-nucleotidase A3L20_16740 ENOG4105CHJ isochorismatase hydrolase A3L20_16765 ENOG41090MY MarR family Transcriptional regulator A3L20_16775 ENOG4105VZ8 Transcriptional regulator A3L20_16810 ENOG4105F6J Alpha beta hydrolase fold A3L20_16825 ENOG4108606 TspO/MBR family A3L20_16830 ENOG4105CVP deoxyribo-dipyrimidine photolyase A3L20_16845 ENOG4108TWJ NADH dehydrogenase subunit 5 A3L20_16850 ENOG4105GPN Uncharacterized conserved protein (DUF2294) A3L20_16865 ENOG4105E1K spore germination protein A3L20_16870 ENOG4107VMI polysaccharide deacetylase A3L20_16880 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase A3L20_16885 ENOG4105DSE periplasmic solute binding protein A3L20_16890 ENOG4105CC5 ABC transporter A3L20_16895 ENOG4105DIK (ABC) transporter A3L20_16920 ENOG4105D6J arsenicaL-resistance protein A3L20_16925 ENOG41085FC arsR family transcriptional regulator A3L20_16970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_16975 ENOG41062D9 Histidine kinase A3L20_17010 ENOG4105DNP FAD linked oxidase domain protein A3L20_17020 ENOG4105C19 ABC transporter A3L20_17050 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A3L20_17055 ENOG4105C0R drug resistance transporter emrb qaca subfamily A3L20_17065 ENOG4105K6H D-cysteine desulfhydrase A3L20_17085 ENOG4105JQZ Methyltransferase A3L20_17115 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) A3L20_17135 ENOG4105BZU Histidine kinase A3L20_17145 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) A3L20_17160 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A A3L20_17180 ENOG4108JQ1 Dehydrogenase A3L20_17185 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) A3L20_17200 ENOG41082W1 Cupin 2, conserved barrel domain protein A3L20_17205 ENOG410874W AraC family transcriptional regulator A3L20_17225 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A3L20_17230 ENOG4108IG5 Transcriptional regulator A3L20_17360 ENOG4108VXD carboxy-peptidase A3L20_17365 ENOG4105PNM synthesis protein A3L20_17375 ENOG4108ISG Major Facilitator A3L20_17390 ENOG4107MII Sugar-specific transcriptional regulator TrmB A3L20_17395 ENOG4105CZM Major Facilitator A3L20_17405 ENOG4105CRW Short chain fatty acid transporter A3L20_17415 ENOG4105DYS nad(p)h dehydrogenase (quinone) A3L20_17475 ENOG4108K8S endonuclease I A3L20_17485 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) A3L20_17490 ENOG4108Z66 YbaK ebsC protein A3L20_17510 ENOG4105KVH Transcriptional regulator A3L20_17515 ENOG4108RCM Nitroreductase A3L20_17545 ENOG4108PSK reductase A3L20_17615 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase A3L20_17620 ENOG4105DKQ ROK family A3L20_17625 ENOG4106UW1 Major Facilitator superfamily A3L20_17630 ENOG4108UW5 maltose o-acetyltransferase A3L20_17635 ENOG4105C31 Tryptophanyl-tRNA synthetase A3L20_17640 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) A3L20_17680 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) A3L20_17690 ENOG4105EV4 Multidrug resistance protein mdtH A3L20_17720 ENOG4105C37 (CBS) domain A3L20_17735 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase A3L20_17740 ENOG4105FAW cDP-glucose 4,6-dehydratase A3L20_17775 ENOG4105DDN Pentapeptide repeat-containing protein A3L20_17780 ENOG4105XDF Protein of unknown function (DUF1272) A3L20_17785 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) A3L20_17790 ENOG4105CMG Carbohydrate kinase A3L20_17795 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A3L20_17805 ENOG4105CV1 Transketolase (EC 2.2.1.1) A3L20_17810 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A3L20_17825 ENOG4105C44 Serine transporter A3L20_17855 ENOG4105KVH Transcriptional regulator A3L20_17860 ENOG4108TZY GntR Family Transcriptional Regulator A3L20_17870 ENOG4105D9R oxidoreductase A3L20_17920 ENOG4105JAB phenazine biosynthesis protein, phzf family A3L20_17935 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein A3L20_17940 ENOG4105KVH Transcriptional regulator A3L20_17945 ENOG4107SCK Monooxygenase A3L20_17965 ENOG4108ZJ4 polysaccharide deacetylase A3L20_18025 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) A3L20_18060 ENOG4105H3G oxidoreductase A3L20_18095 ENOG4105CIS alcohol dehydrogenase A3L20_18130 ENOG4108TN2 lmbE family A3L20_18140 ENOG4107R3E Citrate transporter A3L20_18150 ENOG4105WCN acetyltransferase A3L20_18155 ENOG4108MES Periplasmic binding protein A3L20_18160 ENOG4105EHG Permease protein A3L20_18165 ENOG4105DQ5 transport system permease protein A3L20_18170 ENOG4105NX3 Membrane A3L20_18190 ENOG4107CUJ Protein of unknown function (DUF2690) A3L20_18200 ENOG4107V2S Transcriptional regulator A3L20_18220 ENOG4105C98 muts2 protein A3L20_18230 ENOG4105E5K Alpha-amylase A3L20_18235 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase A3L20_18240 ENOG4105DPN Oligoendopeptidase f A3L20_18245 ENOG4108A04 Beta-lactamase A3L20_18255 ENOG4105E5T Major Facilitator Superfamily A3L20_18270 ENOG4107VXM glycerophosphoryl diester phosphodiesterase A3L20_18280 ENOG41082BM Transcriptional regulator, arsr family A3L20_18285 ENOG4105CB2 alcohol dehydrogenase A3L20_18305 ENOG4105C09 Bile acid A3L20_18310 ENOG4105CQB FAD linked oxidase domain protein A3L20_18330 ENOG4105CEP NADH dehydrogenase A3L20_18355 ENOG4105D2T synthase A3L20_18370 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) A3L20_18375 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A3L20_18380 ENOG4105C1B dTDP-glucose 4-6-dehydratase A3L20_18385 ENOG4105C5E polysaccharide biosynthesis protein A3L20_18425 ENOG4105CJ1 ABC, transporter A3L20_18430 ENOG4105BZ1 (ABC) transporter A3L20_18450 ENOG4108M1A Chitin-binding protein A3L20_18460 ENOG4105E1K spore germination protein A3L20_18480 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase A3L20_18495 ENOG4105FAW cDP-glucose 4,6-dehydratase A3L20_18545 ENOG4105BZU Histidine kinase A3L20_18555 ENOG4105C5H ABC transporter A3L20_18560 ENOG41067SE Tetr family transcriptional regulator A3L20_18565 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity A3L20_18575 ENOG4108VXD carboxy-peptidase A3L20_18580 ENOG4107DUR UPF0457 protein A3L20_18600 ENOG4105BZU Histidine kinase A3L20_18610 ENOG4105KT7 mgtC SapB transporter A3L20_18620 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A3L20_18625 ENOG4105DQ6 Transposase A3L20_18630 ENOG4105IYK transposase A3L20_18635 ENOG41073R8 VanW family A3L20_18645 ENOG4108R1P A3L20_18660 ENOG4105VEQ Cold shock protein A3L20_18680 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) A3L20_18700 ENOG410904N short-chain dehydrogenase reductase A3L20_18710 ENOG4106IQC argininosuccinate lyase A3L20_18725 ENOG4108IA2 Sodium pantothenate symporter A3L20_18735 ENOG4105C26 Dehydrogenase A3L20_18740 ENOG4105CHR reductase A3L20_18750 ENOG4105EWU Squalene--hopene cyclase A3L20_18760 ENOG4105FR1 rard protein A3L20_18765 ENOG410696E Membrane A3L20_18780 ENOG4105D1F ATP-binding protein A3L20_18790 ENOG4108ZAF Molybdopterin A3L20_18795 ENOG4105CVM Molybdenum cofactor synthesis domain protein A3L20_18800 ENOG4105D06 uba thif-type nad fad binding protein A3L20_18805 ENOG4105TMB Formate nitrite transporter A3L20_18815 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A3L20_18820 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) A3L20_18830 ENOG4108JB9 formate dehydrogenase A3L20_18835 ENOG4105E1K spore germination protein A3L20_18850 ENOG4105CUB amino acid A3L20_18905 ENOG4107QJT sodium dicarboxylate symporter A3L20_18910 ENOG4108KGH TRANSCRIPTIONal A3L20_18920 ENOG4105EMN RNA polymerase sigma factor A3L20_18930 ENOG4105CIG ABC transporter A3L20_18950 ENOG4105D9R oxidoreductase A3L20_18960 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A3L20_18965 ENOG4105K4P CoA-binding domain protein A3L20_18970 ENOG4105C0H protease A3L20_18975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_18985 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase A3L20_18990 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A3L20_18995 ENOG4105W8X HesB YadR YfhF-family protein A3L20_19020 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A3L20_19025 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A3L20_19030 ENOG4105BZ1 (ABC) transporter A3L20_19035 ENOG4108I0Z Aconitate hydratase A3L20_19065 ENOG4105E5W Transporter A3L20_19075 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A3L20_19095 ENOG4107F3J Amp-dependent synthetase and ligase A3L20_19100 ENOG4107ZYJ bioY protein A3L20_19105 ENOG4105CEY Amp-dependent synthetase and ligase A3L20_19110 ENOG4108IMY Transcriptional regulator A3L20_19150 ENOG4107AYK membrAne A3L20_19160 ENOG4105BZU Histidine kinase A3L20_19165 ENOG4105FBA Phospholipase Carboxylesterase A3L20_19170 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase A3L20_19175 ENOG4105CK7 Sodium proline symporter A3L20_19185 ENOG4105CBC glutamate synthase A3L20_19190 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A3L20_19195 ENOG4108VJ1 Transcriptional regulator (CarD family A3L20_19200 ENOG4108903 Formimidoylglutamase A3L20_19255 ENOG4107QIV Cytochrome c biogenesis protein A3L20_19265 ENOG4105CH2 amidohydrolase A3L20_19270 ENOG4105IYK transposase A3L20_19275 ENOG4105DQ6 Transposase A3L20_19310 ENOG4107RSM transcriptional regulator A3L20_19315 ENOG4105VAW lrga family A3L20_19320 ENOG41067MG lrgb family A3L20_19365 ENOG4105BZ1 (ABC) transporter A3L20_19370 ENOG4105BZ1 (ABC) transporter A3L20_19405 ENOG4108HW3 (ABC) transporter A3L20_19410 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic A3L20_19430 ENOG4108SVB resolvase A3L20_19450 ENOG4105K7K Transcriptional regulator A3L20_19460 ENOG4105E4C Lytic transglycosylase catalytic A3L20_19465 ENOG41065S2 pneumococcal vaccine antigen A3L20_19500 ENOG4105C5F glutamine synthetase A3L20_19505 ENOG4105KV4 Transcriptional regulator A3L20_19510 ENOG4105CXI aluminum resistance protein A3L20_19515 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A3L20_19520 ENOG4105EN6 Membrane A3L20_19530 ENOG4106F1P AAA ATPase, central domain protein A3L20_19555 ENOG41069ER domain protein A3L20_19560 ENOG4105DM4 PTS System A3L20_19565 ENOG4105DE4 1-phosphofructokinase A3L20_19570 ENOG4105E98 transcriptional regulator DeoR family A3L20_19575 ENOG4107QW4 alcohol dehydrogenase A3L20_19580 ENOG4108SJC Membrane A3L20_19595 ENOG4105C85 amino acid A3L20_19615 ENOG4105TMB Formate nitrite transporter A3L20_19620 ENOG4105K70 DNA-binding protein A3L20_19630 ENOG4105C59 p-type ATPase A3L20_19635 ENOG410681U heavy metal transport detoxification protein A3L20_19640 ENOG4105VPX protein, conserved in bacteria A3L20_19660 ENOG4105NIV Esterase A3L20_19665 ENOG4105E0A ABC, transporter A3L20_19685 ENOG4105CGK Exodeoxyribonuclease III A3L20_19695 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A3L20_19700 ENOG4105D03 DNA-3-methyladenine glycosylase II A3L20_19730 ENOG4105BZU Histidine kinase A3L20_19750 ENOG4105C5E polysaccharide biosynthesis protein A3L20_19770 ENOG41067MG lrgb family A3L20_19795 ENOG4105C8Q Methyl-accepting chemotaxis A3L20_19800 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C A3L20_19810 ENOG4105F0V Cell wall hydrolase A3L20_19825 ENOG410890F Dynamin family A3L20_19870 ENOG4105CZV ABC transporter A3L20_19875 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family A3L20_19895 ENOG4105NA0 Transcriptional regulator A3L20_19910 ENOG4105DQ6 Transposase A3L20_19915 ENOG4105C8Q Methyl-accepting chemotaxis A3L20_19920 ENOG4107VMI polysaccharide deacetylase A3L20_19930 ENOG4108IMY Transcriptional regulator A3L20_19975 ENOG4105DQU oxidoreductase, subunit beta A3L20_19980 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein A3L20_19985 ENOG4108IGT Dipeptidase A3L20_19990 ENOG4105MCT stage V sporulation protein S A3L20_19995 ENOG4105D48 metallophosphoesterase A3L20_20020 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase A3L20_20035 ENOG4105XZV Protein of unknown function (DUF3243) A3L20_20040 ENOG4108RKS Short-chain dehydrogenase reductase Sdr A3L20_20060 ENOG4105UIB (ABC) transporter A3L20_20065 ENOG4108JQ9 ABC transporter A3L20_20070 ENOG4105DIH basic membrane A3L20_20075 ENOG4105FDP GntR family transcriptional regulator A3L20_20080 ENOG4105CNU cell division protein FtsK A3L20_20090 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit A3L20_20100 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A3L20_20110 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A3L20_20115 ENOG4108S0H Dipicolinic acid synthetase, b subunit A3L20_20120 ENOG4105E35 Dipicolinate synthase subunit A A3L20_20130 ENOG4105C1V Peptidase, M16 A3L20_20150 ENOG4105DTN riboflavin biosynthesis protein ribF A3L20_20165 ENOG4105W7A Protein of unknown function (DUF503) A3L20_20175 ENOG4105VHM ribosomal protein A3L20_20180 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination A3L20_20185 ENOG4105CHV Transcription elongation factor NusA A3L20_20195 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A3L20_20205 ENOG4105DZP Membrane-associated zinc metalloprotease A3L20_20210 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) A3L20_20215 ENOG4105KNE Phosphatidate cytidylyltransferase A3L20_20220 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A3L20_20230 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A3L20_20260 ENOG4108HE4 integrase family A3L20_20270 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A3L20_20275 ENOG4105C79 DNA protecting protein DprA A3L20_20280 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha A3L20_20295 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) A3L20_20320 ENOG4105VB6 UPF0109 protein A3L20_20340 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A3L20_20345 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) A3L20_20360 ENOG4105CHR reductase A3L20_20365 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A3L20_20380 ENOG4105CB5 ATP-dependent DNA helicase recG A3L20_20385 ENOG4105DP4 dak2 domain fusion protein ylov A3L20_20390 ENOG4108ZAA Alkaline-shock protein A3L20_20405 ENOG4105FJ0 thiamine A3L20_20410 ENOG4105DJV ribulose-phosphate 3-epimerase A3L20_20415 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) A3L20_20420 ENOG4105D9P serine threonine protein kinase A3L20_20425 ENOG4108ZF3 Phosphatase A3L20_20435 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A3L20_20450 ENOG4105C25 Primosomal protein n' A3L20_20455 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A3L20_20475 ENOG4105DSJ YicC domain protein A3L20_20485 ENOG4105F23 Fibronectin-binding protein A3L20_20575 ENOG4105C34 Pseudouridine synthase A3L20_20590 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A3L20_20600 ENOG4105DBK s4 domain protein A3L20_20605 ENOG41067XK integral membrane protein A3L20_20615 ENOG4105DFA alanine racemase domain protein A3L20_20620 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase A3L20_20625 ENOG4105WR5 sporulation protein, YlmC YmxH family A3L20_20635 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3L20_20645 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) A3L20_20650 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) A3L20_20660 ENOG4105D4A Cell wall formation (By similarity) A3L20_20665 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A3L20_20670 ENOG4105CNI cell division protein FtsW A3L20_20685 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A3L20_20690 ENOG4105CJN penicillin-binding protein A3L20_20695 ENOG4105CJN penicillin-binding protein A3L20_20735 ENOG4105KNH Nucleic acid-binding protein A3L20_20745 ENOG41063PX domain protein A3L20_20750 ENOG4105D78 K07001 NTE family protein A3L20_20755 ENOG4105H20 Sporulation integral membrane protein YlbJ A3L20_20765 ENOG4106H78 methyltransferase A3L20_20785 ENOG4107TB6 phosphoglycerate mutase A3L20_20800 ENOG4106UY4 Inherit from COG: Scp-like extracellular A3L20_20855 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) A3L20_20860 ENOG4105CNI cell division protein FtsW A3L20_20875 ENOG4108IAB Phoh family A3L20_20895 ENOG4105QA2 A3L20_20900 ENOG4105CI3 gtp-binding protein typa A3L20_20910 ENOG4105ECY inositol monophosphatase A3L20_20930 ENOG4105CXN decarboxylase A3L20_20980 ENOG4105CPP Dehydrogenase, E1 component A3L20_20995 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A3L20_21000 ENOG4108X4Q Hydrolase A3L20_21010 ENOG4105CN5 Metallo-Beta-Lactamase A3L20_21015 ENOG4107ZYR domain protein A3L20_21050 ENOG4108XRC Protein of unknown function (DUF458) A3L20_21060 ENOG4107IN1 Protein of unknown function (DUF1797) A3L20_21075 ENOG4105EPM Diguanylate phosphodiesterase A3L20_21080 ENOG4105K6S Short-chain dehydrogenase reductase Sdr A3L20_21100 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) A3L20_21110 ENOG4105UIN A3L20_21165 ENOG4108HGU Histidine kinase A3L20_21175 ENOG4105CHM Aminotransferase A3L20_21180 ENOG4105FKQ transcriptional regulator A3L20_21185 ENOG4105EG2 ABC transporter, permease A3L20_21195 ENOG4107FKK extracellular solute-binding protein family 1 A3L20_21205 ENOG4105CG3 alpha amylase, catalytic region A3L20_21250 ENOG4105CHU acetyl-coa acetyltransferase A3L20_21280 ENOG4105K7K Transcriptional regulator A3L20_21285 ENOG4105DTD Dehydrogenase A3L20_21305 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A3L20_21330 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) A3L20_21345 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A3L20_21355 ENOG4105BZU Histidine kinase A3L20_21375 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) A3L20_21390 ENOG4105CID antiterminator A3L20_21400 ENOG4105FDP GntR family transcriptional regulator A3L20_21410 ENOG4105CE4 GlcNAc 6-P deacetylase A3L20_21445 ENOG4107ZE5 PPIases accelerate the folding of proteins A3L20_21450 ENOG4105PTM secreted protein A3L20_21455 ENOG4105J7I hydrolase A3L20_21465 ENOG4105G6R Stage v sporulation protein ae A3L20_21475 ENOG4105CZ3 stage V sporulation protein ad A3L20_21480 ENOG41090VF Stage v sporulation protein ac A3L20_21500 ENOG4105C8J )-transporter A3L20_21505 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3L20_21515 ENOG41082AN stage II sporulation protein A3L20_21520 ENOG4105DZ1 carboxypeptidase A3L20_21525 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A3L20_21530 ENOG4105DVE abc transporter atp-binding protein A3L20_21570 ENOG4105D7N magnesium and cobalt transport protein CorA A3L20_21595 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A3L20_21605 ENOG4105I3K Ferric uptake regulator, Fur family A3L20_21610 ENOG4105MZ9 stage II sporulation protein m A3L20_21630 ENOG4105CPC Aldo Keto reductase A3L20_21640 ENOG4105RHY Pfam:UPF0157 A3L20_21660 ENOG4107SKW Inherit from COG: Alpha beta hydrolase A3L20_21670 ENOG4105ETE Transcriptional regulator (LacI family A3L20_21675 ENOG4108YM7 Gcn5-related n-acetyltransferase A3L20_21695 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) A3L20_21700 ENOG4108R6K riboflavin synthase, subunit alpha A3L20_21725 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) A3L20_21730 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) A3L20_21745 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A3L20_21755 ENOG4105DFD Na H antiporter A3L20_21760 ENOG4105CGH 5'-nucleotidase A3L20_21785 ENOG4105DBV ornithine carbamoyltransferase A3L20_21800 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) A3L20_21815 ENOG4108IXY short-chain dehydrogenase reductase A3L20_21820 ENOG41069FQ Metallo-beta-lactamase superfamily A3L20_21825 ENOG4105II7 pyrroline-5-carboxylate reductase A3L20_21830 ENOG4105EJQ L-serine dehydratase A3L20_21855 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic A3L20_21870 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) A3L20_21875 ENOG4105D9U N-acetyltransferase A3L20_21885 ENOG4108VZI ErfK ybiS ycfS ynhG family protein A3L20_21890 ENOG4108QEG Membrane A3L20_21895 ENOG4105CDA abc transporter atp-binding protein A3L20_21900 ENOG4105E5Q amino acid AbC transporter A3L20_21905 ENOG4108HW3 (ABC) transporter A3L20_21915 ENOG4105G7B Protein of unknown function (DUF2992) A3L20_21925 ENOG4108QY0 Membrane A3L20_21935 ENOG4105C7S Dehydrogenase A3L20_21940 ENOG4105CPP Dehydrogenase, E1 component A3L20_21960 ENOG4107RDP Dehydrogenase A3L20_21970 ENOG4108JUB Transcriptional regulator A3L20_21980 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A3L20_21995 ENOG4107QQR Sporulation A3L20_22000 ENOG4105S1Z Stage IV sporulation protein B A3L20_22005 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) A3L20_22010 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) A3L20_22015 ENOG4105DX0 Hemolysin A A3L20_22025 ENOG4105CTB Polyprenyl synthetase A3L20_22050 ENOG4108ZSR alkaline shock protein A3L20_22055 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A3L20_22075 ENOG410644B Stage III sporulation protein af A3L20_22085 ENOG4105KQ4 Stage iii sporulation protein ad A3L20_22090 ENOG4108CQH stage III sporulation protein AC A3L20_22095 ENOG4105KR5 Stage iii sporulation protein A3L20_22100 ENOG4105CD2 stage iii sporulation protein aa A3L20_22125 ENOG4105DC7 peptidase M24 A3L20_22140 ENOG4105CBJ Metal-dependent enzyme A3L20_22150 ENOG4107YBY Hydrolase A3L20_22180 ENOG41082GG biotin lipoate A B protein ligase A3L20_22185 ENOG4105WZW rhodanese family A3L20_22210 ENOG41080TC multidrug resistance protein A3L20_22250 ENOG4105C0D helicase A3L20_22335 ENOG4107R6U sodium dicarboxylate symporter A3L20_22370 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A3L20_22375 ENOG4105C3R Methionine synthase A3L20_22385 ENOG4105C28 cystathionine A3L20_22390 ENOG4105C28 cystathionine A3L20_22410 ENOG4105C5X domain protein A3L20_22415 ENOG4105DKQ ROK family A3L20_22425 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase A3L20_22440 ENOG4108UTW Plays a role in the regulation of phosphate uptake A3L20_22445 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A3L20_22450 ENOG4105C8U phosphate abc transporter A3L20_22455 ENOG4105C8U phosphate abc transporter A3L20_22465 ENOG4107RF6 penicillin-binding protein A3L20_22475 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A3L20_22500 ENOG4105N80 Ferric uptake regulator, Fur family A3L20_22510 ENOG4105FDK ABC transporter A3L20_22515 ENOG4108JYZ YitT family A3L20_22520 ENOG41069ZM Protein of unknown function (DUF2624) A3L20_22545 ENOG4105EGD dinuclear metal center protein, YbgI family A3L20_22560 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3L20_22565 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A3L20_22590 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A3L20_22595 ENOG4105KG3 cytidine deaminase A3L20_22600 ENOG4107YR5 Diacylglycerol kinase A3L20_22610 ENOG4105CTJ Metal Dependent Phosphohydrolase A3L20_22615 ENOG4105C9A Phoh family A3L20_22625 ENOG41068P3 sporulation protein YqfC A3L20_22630 ENOG4105KTH gatB Yqey A3L20_22640 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A3L20_22645 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) A3L20_22675 ENOG4105CSA Coproporphyrinogen iii oxidase A3L20_22680 ENOG4105KVH Transcriptional regulator A3L20_22705 ENOG4105TQK DNA polymerase iii, delta' subunit A3L20_22715 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 A3L20_22720 ENOG4108UK2 deaminase A3L20_22725 ENOG4105KQC Competence protein A3L20_22735 ENOG4105DXX methyltransferase A3L20_22745 ENOG4108WF2 Metal Dependent Phosphohydrolase A3L20_22755 ENOG410812S Rna-binding protein A3L20_22765 ENOG4105CQW ribosome biogenesis GTPase YqeH A3L20_22770 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase A3L20_22785 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3L20_22805 ENOG4108TVJ Nitroreductase A3L20_22820 ENOG4105G6Z alkaline phosphatase A3L20_22825 ENOG4105KEG ribosomal-protein-alanine acetyltransferase A3L20_22830 ENOG4108MUZ hydrolase A3L20_22865 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin A3L20_22870 ENOG4105MIR Phenylalanine 4-monooxygenase A3L20_22880 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A3L20_22920 ENOG4105S6R Iron-hydroxamate transporter permease subunit A3L20_22925 ENOG4108V5C ABC transporter A3L20_22935 ENOG4108EKI Dehydrogenase A3L20_22940 ENOG4105C28 cystathionine A3L20_22970 ENOG4107XRG penicillin-binding protein A3L20_22980 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) A3L20_22990 ENOG4105CFP Peptidase U32 A3L20_22995 ENOG4105XYU peptidase (U32 family) A3L20_23000 ENOG4108VQJ O-methyltransferase A3L20_23005 ENOG4105HHA aminodeoxychorismate lyase A3L20_23025 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A3L20_23035 ENOG4105C02 permease A3L20_23050 ENOG41060CR A3L20_23055 ENOG4105C7H Helicase, RecD TraA family A3L20_23065 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) A3L20_23070 ENOG4105C3J Cysteine desulfurase A3L20_23080 ENOG4105D1H recombination factor protein RarA A3L20_23085 ENOG4108VCI transcription factor, rsfa family A3L20_23090 ENOG4105CUZ uba thif-type nad fad binding protein A3L20_23100 ENOG4105CUT histidyl-tRNA synthetase A3L20_23120 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A3L20_23130 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A3L20_23135 ENOG41076HS cation diffusion facilitator family transporter A3L20_23140 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A3L20_23150 ENOG4105CKP Polysaccharide Biosynthesis Protein A3L20_23155 ENOG4108QG2 Membrane A3L20_23165 ENOG4105VIE preprotein translocase, subunit YajC A3L20_23180 ENOG41061AI Protein of unknown function (DUF2905) A3L20_23195 ENOG4108HUF Transporter A3L20_23225 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase A3L20_23230 ENOG4108IYU L-aspartate oxidase A3L20_23245 ENOG4108RPX mosc domain containing protein A3L20_23255 ENOG4105CQC Prephenate dehydratase A3L20_23275 ENOG4105EWM Histidine kinase A3L20_23300 ENOG4105X36 (ribosomal) protein A3L20_23310 ENOG4105C03 ribonuclease A3L20_23325 ENOG4107QMS site-determining protein A3L20_23340 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) A3L20_23345 ENOG4105DFF Rod shape-determining protein mreb A3L20_23365 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A3L20_23370 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) A3L20_23380 ENOG41068KH stage VI sporulation protein D A3L20_23390 ENOG4105D52 delta-aminolevulinic acid dehydratase A3L20_23415 ENOG4105K56 Transcriptional regulator A3L20_23435 ENOG4108IUQ atp-dependent protease A3L20_23455 ENOG4108QCI YvbH-like oligomerisation region A3L20_23475 ENOG4105M59 Phosphodiesterase, mj0936 family A3L20_23490 ENOG4108XJQ germination protein A3L20_23500 ENOG4108PCX Major Facilitator A3L20_23510 ENOG4105KBX Transcriptional regulator, TetR family A3L20_23520 ENOG4105PFC Transcriptional regulator A3L20_23530 ENOG4105DZC cytosine deaminase A3L20_23535 ENOG41067S9 phage shock protein C, PspC A3L20_23540 ENOG4108JCI Transcriptional regulator A3L20_23550 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) A3L20_23555 ENOG4108Z40 Transcriptional regulator A3L20_23560 ENOG4105RHA ABC transporter, permease A3L20_23565 ENOG4108IUX (ABC) transporter A3L20_23570 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family A3L20_23575 ENOG4105ER2 Ompa motb domain protein A3L20_23580 ENOG4105E14 MotA TolQ exbB proton channel A3L20_23585 ENOG4108VXD carboxy-peptidase A3L20_23595 ENOG4105E33 succinate dehydrogenase A3L20_23605 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit A3L20_23620 ENOG4105K63 Thioredoxin A3L20_23625 ENOG4105C10 Electron transfer flavoprotein A3L20_23630 ENOG4105BZJ Electron transfer flavoprotein A3L20_23635 ENOG41060WC Enoyl-CoA hydratase A3L20_23640 ENOG4107Z3H Transcriptional regulator, TetR family A3L20_23645 ENOG4105CEY Amp-dependent synthetase and ligase A3L20_23655 ENOG4105J76 Periplasmic binding protein A3L20_23660 ENOG4105S6R Iron-hydroxamate transporter permease subunit A3L20_23695 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A3L20_23710 ENOG4105DR4 Methyltransferase A3L20_23720 ENOG4105KFN sortase, SrtB family A3L20_23725 ENOG4105E0A ABC, transporter A3L20_23740 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) A3L20_23750 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) A3L20_23760 ENOG4105FE9 pseudouridine synthase A3L20_23770 ENOG4105DCG PHP domain protein A3L20_23785 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A3L20_23800 ENOG4105C5S asparaginyl-tRNA synthetase A3L20_23805 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A3L20_23815 ENOG4108RWN rrna methyltransferase A3L20_23840 ENOG4105C0R drug resistance transporter emrb qaca subfamily A3L20_23845 ENOG4105CW7 secretion protein, HlyD family A3L20_23850 ENOG4108JGH Tetr family transcriptional regulator A3L20_23855 ENOG4105CN9 Peptidase m42 family protein A3L20_23875 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) A3L20_23880 ENOG4105C22 threonyL-tRNA synthetase A3L20_23885 ENOG4108TDW sporulation protein YtxC A3L20_23900 ENOG4105DQ6 Transposase A3L20_23920 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) A3L20_23925 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A3L20_23930 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A3L20_23940 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A3L20_23945 ENOG4105C2M dna polymerase I A3L20_23950 ENOG4105BZU Histidine kinase A3L20_23955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A3L20_23975 ENOG4108HMX isocitrate dehydrogenase (NADP) A3L20_23980 ENOG4105BZN citrate synthase A3L20_23990 ENOG4108REF Sporulation integral membrane protein ytvi A3L20_23995 ENOG4105FS0 cytoplasmic membrane protein A3L20_24020 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family A3L20_24025 ENOG4105C6K Malic enzyme A3L20_24030 ENOG4105C0B DNA polymerase III (alpha subunit) A3L20_24035 ENOG4105VV2 A3L20_24045 ENOG4105SFS phosphoesterase RecJ domain protein A3L20_24075 ENOG4105DC7 peptidase M24 A3L20_24110 ENOG4105Z7P Acetyltransferase (GNAT) family A3L20_24115 ENOG41082W1 Cupin 2, conserved barrel domain protein A3L20_24135 ENOG4107YZX Universal stress protein A3L20_24175 ENOG4108JYZ YitT family A3L20_24195 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) A3L20_24205 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) A3L20_24210 ENOG4105KBJ sporulation protein ytfj A3L20_24225 ENOG4105EFZ amidohydrolase A3L20_24235 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A3L20_24260 ENOG4105RQF LysR family Transcriptional regulator A3L20_24270 ENOG4105U5Y Transcriptional regulator A3L20_24280 ENOG4105C28 cystathionine A3L20_24290 ENOG4108IBT Inherit from COG: transposase A3L20_24315 ENOG4108UW5 maltose o-acetyltransferase A3L20_24325 ENOG4105F1V Acetoin utilization protein A3L20_24330 ENOG4105W87 Cbs domain A3L20_24335 ENOG4105DGU Histone deacetylase A3L20_24350 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A3L20_24355 ENOG4105BZU Histidine kinase A3L20_24360 ENOG4107SNB ankyrin repeat protein YahD A3L20_24365 ENOG4105EP9 oxidoreductase A3L20_24395 ENOG4105ETE Transcriptional regulator (LacI family A3L20_24405 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A3L20_24410 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A3L20_24450 ENOG4108IPJ Membrane A3L20_24485 ENOG4108VDD TRNA binding domain protein A3L20_24515 ENOG4105C8F Beta-lactamase domain protein A3L20_24530 ENOG4108V15 phosphotransferase enzyme family A3L20_24535 ENOG4108IUM Glycogen debranching enzyme A3L20_24545 ENOG4107QSE Dipeptidase A3L20_24550 ENOG4105YW5 deoR family transcriptional regulator A3L20_24600 ENOG4108VJ1 Transcriptional regulator (CarD family A3L20_24605 ENOG4107EXU Short-chain dehydrogenase reductase Sdr A3L20_24610 ENOG4105CSC Glucose uptake protein A3L20_24625 ENOG4108ZAF Molybdopterin A3L20_24630 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein A3L20_24635 ENOG4105CVM Molybdenum cofactor synthesis domain protein A3L20_24645 ENOG4105D06 uba thif-type nad fad binding protein A3L20_24650 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A3L20_24670 ENOG41085GJ domain protein A3L20_24680 ENOG4105DWV Homoserine O-trans-acetylase A3L20_24720 ENOG410605W Major Facilitator A3L20_24725 ENOG4107S91 Sodium hydrogen exchanger A3L20_24730 ENOG4105NCW Trka-c domain protein A3L20_24745 ENOG4105C19 ABC transporter A3L20_24765 ENOG4105N5T Radical SAM Protein A3L20_24790 ENOG4105E8V Alpha Beta Hydrolase Fold protein A3L20_24795 ENOG4108Z0R Transferase A3L20_24800 ENOG4105YVM Phosphoesterase, PA-phosphatase related A3L20_24805 ENOG4105BZF Glycosyl transferase (Group 1 A3L20_24815 ENOG4105EPU Molybdenum cofactor synthesis domain protein A3L20_24895 ENOG4105BZU Histidine kinase A3L20_24900 ENOG4105BZU Histidine kinase A3L20_24905 ENOG4105CH6 catalase A3L20_24910 ENOG4107S9D Alpha beta hydrolase A3L20_24915 ENOG4107T7U Sulfatase A3L20_24930 ENOG4105D2X ABC transporter substrate-binding protein A3L20_24940 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component A3L20_25000 ENOG41080TC multidrug resistance protein A3L20_25005 ENOG410839T multidrug resistance protein A3L20_25025 ENOG4108V2W Carbonate dehydratase A3L20_25030 ENOG4105C4M (Ubiquinol oxidase) subunit I A3L20_25035 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A3L20_25050 ENOG4105IYK transposase A3L20_25055 ENOG4105DQ6 Transposase A3L20_25095 ENOG41087YS Phage shock protein A A3L20_25120 ENOG4105N67 Proton-coupled thiamine transporter YuaJ A3L20_25125 ENOG4105BZU Histidine kinase A3L20_25130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_25155 ENOG4108UGV hypoxanthine phosphoribosyltransferase A3L20_25160 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) A3L20_25205 ENOG4107ZTW SNARE associated Golgi A3L20_25220 ENOG4105C19 ABC transporter A3L20_25225 ENOG41086D8 Transcriptional regulator A3L20_25230 ENOG4108FPN Integrase A3L20_25280 ENOG4105CJ1 ABC, transporter A3L20_25290 ENOG41082BM Transcriptional regulator, arsr family A3L20_25335 ENOG4105C6Z Gluconate A3L20_25340 ENOG4105FDP GntR family transcriptional regulator A3L20_25360 ENOG41069H0 dihydroorotase EC 3.5.2.3 A3L20_25380 ENOG4105DTQ mandelate racemase muconate lactonizing A3L20_25390 ENOG4108IPT Naphthoate synthase A3L20_25395 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) A3L20_25405 ENOG4105E4F Isochorismate synthase A3L20_25410 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase A3L20_25420 ENOG4105VEQ Cold shock protein A3L20_25460 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) A3L20_25475 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A3L20_25480 ENOG4108Q5F Tetr family transcriptional regulator A3L20_25615 ENOG4105KT7 mgtC SapB transporter A3L20_25620 ENOG4107PBV potassium channel A3L20_25635 ENOG4105WG9 Conserved Protein A3L20_25645 ENOG4105CHM Aminotransferase A3L20_25650 ENOG4108ZB6 transcriptional regulator AsnC family A3L20_25655 ENOG4105C5I Dehydrogenase A3L20_25660 ENOG4108MUZ hydrolase A3L20_25670 ENOG4105C87 Aminotransferase class I and II A3L20_25685 ENOG4105Y38 Kinase-associated protein B A3L20_25695 ENOG4107R3E Citrate transporter A3L20_25710 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) A3L20_25715 ENOG4105KA0 thioesterase Superfamily protein A3L20_25730 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A3L20_25750 ENOG41069ER domain protein A3L20_25765 ENOG4105CEP NADH dehydrogenase A3L20_25795 ENOG4105EWC Purine nucleoside phosphorylase A3L20_25850 ENOG4105XSJ toxin secretion phage lysis holin A3L20_25985 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3L20_26010 ENOG4108ZUE Phage regulatory protein rha A3L20_26030 ENOG4108IMY Transcriptional regulator A3L20_26075 ENOG4108YX9 iron--sulfur cluster insertion protein erpA A3L20_26100 ENOG4108JJA ABC, transporter A3L20_26105 ENOG4105C4B ABC transporter, permease A3L20_26110 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA A3L20_26140 ENOG41083MR nifu domain-containing protein A3L20_26155 ENOG4108W5N phosphatidylglycerophosphatase a A3L20_26175 ENOG4105DAX Pfam:DUF2983 A3L20_26185 ENOG4105DYS nad(p)h dehydrogenase (quinone) A3L20_26190 ENOG4105D4U had-superfamily hydrolase, subfamily iia A3L20_26205 ENOG4105CBT Fructose-1,6-bisphosphatase A3L20_26220 ENOG4105MMD transcriptional regulator A3L20_26225 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) A3L20_26230 ENOG4107TXC Transcriptional regulator A3L20_26235 ENOG41090T1 Membrane A3L20_26260 ENOG4105FAA peptidase M23 A3L20_26265 ENOG4108YTE sporulation protein YunB A3L20_26270 ENOG4105KZD Domain of unknown function (DUF1805) A3L20_26275 ENOG4107R8B 5'-nucleotidase A3L20_26280 ENOG4105DIW FeS assembly protein SUFB A3L20_26285 ENOG4108UNV SUF system FeS assembly protein, NifU family A3L20_26290 ENOG4105C9B Cysteine desulfurase A3L20_26295 ENOG4105JRK feS assembly protein SufD A3L20_26300 ENOG4105C3K feS assembly ATPase SufC A3L20_26305 ENOG4105D01 (LipO)protein A3L20_26310 ENOG4105D01 (LipO)protein A3L20_26315 ENOG4108UMI ABC transporter, permease A3L20_26320 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A3L20_26345 ENOG41080E8 Transcriptional regulator, Spx MgsR family A3L20_26365 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A3L20_26380 ENOG4108W8B Beta-lactamase domain protein A3L20_26385 ENOG4105C1G acyl-Coa dehydrogenase A3L20_26390 ENOG4105CHU acetyl-coa acetyltransferase A3L20_26405 ENOG4105DZ1 carboxypeptidase A3L20_26425 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer A3L20_26440 ENOG4108SUT Major Facilitator Superfamily A3L20_26445 ENOG4107R7I amino acid A3L20_26460 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A3L20_26475 ENOG4107AYK membrAne A3L20_26510 ENOG4107ZTW SNARE associated Golgi A3L20_26520 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein A3L20_26525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_26530 ENOG4105BZU Histidine kinase A3L20_26565 ENOG4105BZ1 (ABC) transporter A3L20_26570 ENOG4105CJ1 ABC, transporter A3L20_26585 ENOG4105C8Q Methyl-accepting chemotaxis A3L20_26590 ENOG4105C8Q Methyl-accepting chemotaxis A3L20_26595 ENOG4105VG1 fes assembly suf system protein A3L20_26600 ENOG4105D4Y metalloprotease A3L20_26605 ENOG4105C2I pirin domain protein A3L20_26620 ENOG4107T5V SNARE associated Golgi A3L20_26625 ENOG4107S91 Sodium hydrogen exchanger A3L20_26630 ENOG4105NCW Trka-c domain protein A3L20_26640 ENOG4108RMU ferritin dps family protein A3L20_26660 ENOG4108URH decarboxylase A3L20_26675 ENOG4105DHF Membrane A3L20_26680 ENOG4105D9N nucleoside A3L20_26685 ENOG4105D9N nucleoside A3L20_26700 ENOG4108RYK Nad-dependent epimerase dehydratase A3L20_26715 ENOG4105CV8 reductase A3L20_26720 ENOG4105F27 Major Facilitator A3L20_26725 ENOG4105KVH Transcriptional regulator A3L20_26740 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A3L20_26745 ENOG4105D4A Cell wall formation (By similarity) A3L20_26755 ENOG4105C8Q Methyl-accepting chemotaxis A3L20_26770 ENOG4105WMR Protein CrcB homolog A3L20_26790 ENOG4105C5H ABC transporter A3L20_26795 ENOG4108MK9 spermidine N(1)-acetyltransferase A3L20_26805 ENOG4108VY7 phosphate-starvation-inducible protein PsiE A3L20_26815 ENOG4108W2Y isochorismatase A3L20_26835 ENOG4108V2W Carbonate dehydratase A3L20_26840 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) A3L20_26860 ENOG4108IPW abc transporter atp-binding protein A3L20_26865 ENOG4105CM4 permease protein A3L20_26895 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A3L20_26910 ENOG4105CNU cell division protein FtsK A3L20_26925 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase A3L20_26930 ENOG4105XSJ toxin secretion phage lysis holin A3L20_26955 ENOG4105EKQ RNA-directed DNA polymerase A3L20_27000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A3L20_27010 ENOG41085W3 Transposase A3L20_27015 ENOG4105CAR Terminase, large subunit A3L20_27145 ENOG4108IMY Transcriptional regulator A3L20_27170 ENOG4105XZU Preprotein translocase, subunit SecG A3L20_27175 ENOG41067MG lrgb family A3L20_27225 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3L20_27290 ENOG41090VF Stage v sporulation protein ac A3L20_27295 ENOG4105CZ3 stage V sporulation protein ad A3L20_27310 ENOG4108QY0 Membrane A3L20_27315 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A3L20_27320 ENOG4105KRI phosphocarrier protein (HPr A3L20_27330 ENOG4105CHW UPF0052 protein A3L20_27340 ENOG4108Z4K mutator MutT protein A3L20_27350 ENOG4105C3M thioredoxin reductase A3L20_27360 ENOG4108S4C acetyltransferase A3L20_27380 ENOG41086DT Membrane protein of unknown function A3L20_27390 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A3L20_27395 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) A3L20_27410 ENOG4107TXC Transcriptional regulator A3L20_27425 ENOG4105HMI Membrane A3L20_27430 ENOG4105DUM transcriptional regulator, lysR family A3L20_27440 ENOG4108WS4 fmn reductase A3L20_27450 ENOG4105BZ1 (ABC) transporter A3L20_27460 ENOG4105CN1 protease A3L20_27465 ENOG4105CRP Part of the ABC transporter FtsEX involved in A3L20_27470 ENOG4105CAK Cell division ATP-binding protein ftsE A3L20_27480 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) A3L20_27495 ENOG4108RDQ ABC transporter A3L20_27525 ENOG4105MS2 ribosomal subunit Interface protein A3L20_27530 ENOG4105VEQ Cold shock protein A3L20_27535 ENOG41081UC Inherit from COG: Competence protein A3L20_27560 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A3L20_27740 ENOG4108C33 Resolvase A3L20_27755 ENOG4105KVH Transcriptional regulator A3L20_27765 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein A3L20_27770 ENOG4108KGH TRANSCRIPTIONal A3L20_27775 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase A3L20_27780 ENOG4105C6Y Udp-glucose 6-dehydrogenase A3L20_27785 ENOG4105ESV Glycosyl transferase, family 4 A3L20_27795 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A3L20_27815 ENOG4105F8D glycoside hydrolase family 4 A3L20_27820 ENOG4105VCP PTS System A3L20_27825 ENOG4105CK1 PTS System A3L20_27835 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) A3L20_27840 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) A3L20_27845 ENOG4105VCP PTS System A3L20_27855 ENOG4105VZJ PTS System A3L20_27875 ENOG4105ECB domain protein A3L20_27880 ENOG4107RSM transcriptional regulator A3L20_27915 ENOG4105DAA L-lactate A3L20_27925 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) A3L20_27935 ENOG4105E0M Sulfatase A3L20_27940 ENOG4105DQ6 Transposase A3L20_27970 ENOG4107R8N Glycosyl transferase, family 2 A3L20_27980 ENOG4105C94 Transporter A3L20_27985 ENOG41069ER domain protein A3L20_28010 ENOG4105KBK Zinc finger, swim domain protein A3L20_28015 ENOG4105C0D helicase A3L20_28025 ENOG41085W3 Transposase A3L20_28050 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3L20_28060 ENOG4107RBB ABC transporter, permease A3L20_28065 ENOG4105C19 ABC transporter A3L20_28075 ENOG4105CXY transporter A3L20_28090 ENOG4105BZU Histidine kinase A3L20_28095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_28105 ENOG4108KGH TRANSCRIPTIONal A3L20_28110 ENOG4105CMR udp-glucose 4-epimerase A3L20_28115 ENOG4105C6Y Udp-glucose 6-dehydrogenase A3L20_28125 ENOG4105K64 Glycosyl transferase, family 2 A3L20_28160 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A3L20_28165 ENOG4108RB3 Capsular polysaccharide biosynthesis protein A3L20_28170 ENOG4107YJ4 chain length determinant protein A3L20_28175 ENOG4105HTX biosynthesis protein A3L20_28180 ENOG4105IYK transposase A3L20_28185 ENOG4105DQ6 Transposase A3L20_28190 ENOG4107YJ4 chain length determinant protein A3L20_28205 ENOG4105MT0 Sporulation transcriptional regulator spoiiid A3L20_28215 ENOG4105FRN stage II sporulation protein A3L20_28230 ENOG4105DY9 regulatoR A3L20_28250 ENOG4106778 Protein of unknown function (DUF1146) A3L20_28255 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3L20_28260 ENOG4105C8S subunit m A3L20_28265 ENOG4105D65 subunit l A3L20_28290 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3L20_28295 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A3L20_28305 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A3L20_28310 ENOG4105BZU Histidine kinase A3L20_28360 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) A3L20_28365 ENOG41062M3 atp synthase A3L20_28385 ENOG4108UIC UPF0340 protein A3L20_28390 ENOG4108YZG isomerase A3L20_28405 ENOG4108VGI doxx family A3L20_28410 ENOG4107XC4 flavin reductase domain protein, FMN-binding A3L20_28425 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A3L20_28435 ENOG4108ZXQ stage ii sporulation protein r A3L20_28440 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A3L20_28445 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A3L20_28460 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) A3L20_28465 ENOG4105CBT Fructose-1,6-bisphosphatase A3L20_28470 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A3L20_28505 ENOG4105C1G acyl-Coa dehydrogenase A3L20_28510 ENOG4105C1G acyl-Coa dehydrogenase A3L20_28515 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A3L20_28525 ENOG4105DF6 Fe-S oxidoreductase A3L20_28540 ENOG4105BZU Histidine kinase A3L20_28555 ENOG4105D4Y metalloprotease A3L20_28565 ENOG4105BZU Histidine kinase A3L20_28570 ENOG4105KCT ABC transporter A3L20_28575 ENOG4108M15 ABC transporter A3L20_28580 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) A3L20_28590 ENOG4105IIU Aminopeptidase A3L20_28610 ENOG4105EMN RNA polymerase sigma factor A3L20_28620 ENOG410684U Domain of unknown function (DUF1934) A3L20_28640 ENOG4105CYW agmatinase A3L20_28650 ENOG4105DXB Major Facilitator superfamily A3L20_28655 ENOG4107SWG transcriptional regulator MERR family A3L20_28660 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A3L20_28665 ENOG4105BZ4 penicillin-binding protein A3L20_28670 ENOG4108XFG YwhD family A3L20_28675 ENOG4108Z4T Peptidase M50 A3L20_28680 ENOG41069HH 4-oxalocrotonate tautomerase A3L20_28685 ENOG4105DCI Phosphohydrolase A3L20_28690 ENOG4108MES Periplasmic binding protein A3L20_28695 ENOG4105E0A ABC, transporter A3L20_28700 ENOG4105EHG Permease protein A3L20_28705 ENOG4105DQ5 transport system permease protein A3L20_28715 ENOG4108VCI transcription factor, rsfa family A3L20_28720 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) A3L20_28725 ENOG4108IJ2 phosphate acetyltransferase A3L20_28730 ENOG4107UEZ chlorite dismutase A3L20_28740 ENOG4108VKI Cell wall hydrolase A3L20_28760 ENOG4107SVH Potassium channel protein A3L20_28770 ENOG410667J hydrolase A3L20_28775 ENOG4105VCH membrane A3L20_28785 ENOG4108TU7 Inherit from COG: (ABC) transporter A3L20_28790 ENOG4105CJ1 ABC, transporter A3L20_28795 ENOG41090WU lipolytic protein G-D-S-L family A3L20_28810 ENOG4105D6E homoserine dehydrogenase A3L20_28830 ENOG4108Y4K DNA-binding transcriptional activator A3L20_28840 ENOG4105WH1 Two component transcriptional regulator luxr family A3L20_28845 ENOG4105BZU Histidine kinase A3L20_28850 ENOG4105DWF phosphomethylpyrimidine kinase A3L20_28855 ENOG4105BZU Histidine kinase A3L20_28860 ENOG4105VCD cytoplasmic protein A3L20_28865 ENOG4105D22 carbon starvation protein A3L20_28870 ENOG4105DY9 regulatoR A3L20_28875 ENOG41079KZ Major Facilitator Superfamily A3L20_28885 ENOG4105CG5 Glycosyl transferase (Group 1 A3L20_28895 ENOG4105EN6 Membrane A3L20_28900 ENOG4106YBV Methyl-accepting chemotaxis A3L20_28910 ENOG4108S4H thioesterase Superfamily protein A3L20_28915 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) A3L20_28930 ENOG4105K64 Glycosyl transferase, family 2 A3L20_28945 ENOG4105CKK Glycosyl transferase, family 2 A3L20_28955 ENOG4108IG5 Transcriptional regulator A3L20_28960 ENOG4105C5H ABC transporter A3L20_28965 ENOG41067SE Tetr family transcriptional regulator A3L20_28975 ENOG4105E0X reductase A3L20_28980 ENOG4106F5Q Membrane A3L20_28995 ENOG4108NEV two component transcriptional regulator, LytTR family A3L20_29000 ENOG4108HRK Histidine kinase A3L20_29005 ENOG4107RGD Major Facilitator superfamily A3L20_29020 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A3L20_29030 ENOG4105IW1 AmiS UreI transporter A3L20_29040 ENOG4105CMR udp-glucose 4-epimerase A3L20_29045 ENOG4108UT2 hemolysin iii A3L20_29055 ENOG4105C1J atp-dependent rna helicase A3L20_29060 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) A3L20_29065 ENOG4105DPN Oligoendopeptidase f A3L20_29080 ENOG4105BZU Histidine kinase A3L20_29095 ENOG4105C0H protease A3L20_29100 ENOG4105Q2H domain protein A3L20_29115 ENOG4105BZU Histidine kinase A3L20_29120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3L20_29145 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A3L20_29150 ENOG4105CDU Replicative dna helicase A3L20_29160 ENOG4105BZR domain protein A3L20_29165 ENOG4108XMW Membrane A3L20_29175 ENOG4108UUM single-stranded DNA-binding protein A3L20_29185 ENOG4105C3G gtp-binding protein A3L20_29190 ENOG4105VDK protein, conserved in bacteria A3L20_29195 ENOG4105D8X mechanosensitive ion channel A3L20_29200 ENOG4108ZDA Sporulation protein YyaC A3L20_29205 ENOG4105FA0 parb-like partition protein A3L20_29210 ENOG4107QJE Chromosome Partitioning Protein A3L20_29230 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) A3L20_29240 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A3L20_29435 ENOG4105XSJ toxin secretion phage lysis holin A3L20_29510 ENOG4108IMY Transcriptional regulator A3L20_29530 ENOG4108ZUE Phage regulatory protein rha A3L20_29555 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3L20_29745 ENOG4105XSJ toxin secretion phage lysis holin A3L20_29785 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A3L20_29880 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) A3L20_29895 ENOG4105EKQ RNA-directed DNA polymerase A3L20_29955 ENOG4105DR5 peptidase A3L20_30065 ENOG4105C9U ATP-dependent DNA helicase RecQ A3L20_30140 ENOG4105BZ1 (ABC) transporter A3L20_30145 ENOG4105BZ1 (ABC) transporter A3L20_30150 ENOG4105C6Y Udp-glucose 6-dehydrogenase A3L20_30200 ENOG4105CPF Cell wall formation (By similarity) A3L20_30215 ENOG4108V4B ThiJ pfpI A3L20_30285 ENOG4105DVF Cytosine-specific methyltransferase A3L20_30330 ENOG4105KRN Transcriptional regulator, abrb family A3L20_30365 ENOG4107QJE Chromosome Partitioning Protein A3L20_30390 ENOG41067QW Transcriptional regulator A3L20_30405 ENOG410682Q Phage transcriptional regulator, ArpU A3L20_30420 ENOG41085W3 Transposase A3L20_30480 ENOG4108IBT Inherit from COG: transposase A3L20_30540 ENOG4105H67 Protein of unknown function (DUF421) A3L20_30545 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A3L20_30550 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A3L20_30555 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit A3L20_30560 ENOG4108IFG nitrite reductase, (NAD(P)H) A3L20_30665 ENOG41085W3 Transposase A3L20_30675 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis A3L20_30760 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A3L20_30790 ENOG4106050 phage regulatory protein, rha family A3L20_30855 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) A3L20_30885 ENOG4108C33 Resolvase A3L20_30900 ENOG4108N0N Phage Terminase Large Subunit A3L20_30930 ENOG4105D13 transposase A3L20_30950 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A3L20_30970 ENOG4108IFG nitrite reductase, (NAD(P)H) A3L20_30975 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit A3L20_30980 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A3L20_30985 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A3L20_30990 ENOG4105H67 Protein of unknown function (DUF421) A3L20_31050 ENOG4108IBT Inherit from COG: transposase A3L20_31075 ENOG410780I phosphoprotein phosphatase activity A3L20_31115 ENOG4108J59 Extracellular solute-binding protein, family 5 A3L20_31145 ENOG4107QJE Chromosome Partitioning Protein A3L20_31165 ENOG4105IYK transposase A3L20_31170 ENOG4105DQ6 Transposase A3L20_31190 ENOG4108J59 Extracellular solute-binding protein, family 5 A3L20_31205 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A3L20_31235 ENOG4108IBT Inherit from COG: transposase A3L20_31250 ENOG4105DQ6 Transposase A3L20_31275 ENOG4107QJE Chromosome Partitioning Protein A3L20_31305 ENOG4108J59 Extracellular solute-binding protein, family 5 A3L20_31345 ENOG410780I phosphoprotein phosphatase activity A3L20_31455 ENOG4105EKQ RNA-directed DNA polymerase A3L20_31475 ENOG4105EKQ RNA-directed DNA polymerase A3L20_31485 ENOG4105EKQ RNA-directed DNA polymerase A3L20_31495 ENOG4105EKQ RNA-directed DNA polymerase A3L20_31525 ENOG4105EKQ RNA-directed DNA polymerase A3L20_31610 ENOG4105KRN Transcriptional regulator, abrb family A3L20_31615 ENOG4108J59 Extracellular solute-binding protein, family 5 A3L20_31630 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A3L20_31645 ENOG4108IBT Inherit from COG: transposase A3L20_31695 ENOG41075H3 AraC family transcriptional regulator A3L20_31750 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase A3L20_31770 ENOG4105XSJ toxin secretion phage lysis holin A3L20_31825 ENOG4105BZU Histidine kinase A3L20_31875 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A3L20_31905 ENOG4105D7V transposase A3L20_31920 ENOG4105XSJ toxin secretion phage lysis holin A3L20_31935 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase A3L20_31940 ENOG4107DUR UPF0457 protein A3L20_31990 ENOG4105BZ1 (ABC) transporter A3L20_32010 ENOG4105K70 DNA-binding protein A3L20_32030 ENOG41085W3 Transposase A3L20_32070 ENOG4105C7B Threonine dehydratase A3L20_32080 ENOG4107R7I amino acid A3L20_32100 ENOG4107RSM transcriptional regulator A3L20_32105 ENOG4107AYK membrAne A3L20_32110 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) A3L20_32140 ENOG41082BM Transcriptional regulator, arsr family A3L20_32150 ENOG4105C7F AcnD-accessory protein PrpF A3L20_32185 ENOG4105D7V transposase A3L20_32205 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) A3L20_32265 ENOG4105C0H protease A3L20_32270 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A3L20_32285 ENOG4105DZ2 Transcriptional regulator A3L20_32290 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C A3L20_32475 ENOG4105EKQ RNA-directed DNA polymerase A3L20_32515 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A3L20_32520 ENOG4105VIZ double-strand break repair protein